title: ABCB1 C3435T polymorphism influences the risk for Alzheimer's disease.
abstract: To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls). Single-marker analyses revealed a significant association solely for the rs1045642 polymorphism (C/C genotype carriers had increased risk for AD), which remains significant after correction for multiple testing. Haplotype analyses indicated three nominally significant associations which were lost after applying multiple test correction.
authors.affiliation: Department of Psychiatry, University of Szeged, 57 Kálvária Ave, Szeged, 6724, Hungary, feher.agnes@med.u-szeged.hu.
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Fehér
authors.forename: Anna
authors.initials: A
authors.lastname: Juhász
authors.forename: Magdolna
authors.initials: M
authors.lastname: Pákáski
authors.forename: János
authors.initials: J
authors.lastname: Kálmán
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Janka
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B