title: Benzyl isothiocyanate inhibits IL-13 expression in human basophilic KU812 cells.
abstract: An allergen-stimulating cytokine, interleukin-13 (IL-13), plays a significant role in allergic inflammation. Benzyl isothiocyanate (BITC), derived from several cruciferous vegetables, significantly suppressed the IL-13 expression in the calcium ionophore-stimulated human basophilic KU812 cells. Down-regulation of phosphorylated mitogen-activated protein kinases as well as nuclear transcriptional factors might be involved in the underlying mechanism.
authors.affiliation: a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
authors.forename: Yue
authors.initials: Y
authors.lastname: Tang
authors.forename: Naomi
authors.initials: N
authors.lastname: Abe
authors.forename: Motoko
authors.initials: M
authors.lastname: Yoshimoto
authors.forename: Beiwei
authors.initials: B
authors.lastname: Zhu
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Murata
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001491:Basophils / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D000001:Calcimycin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D061207:Calcium Ionophores / Q000494:pharmacology; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D018793:Interleukin-13 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D017879:Isothiocyanates / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D050778:NFATC Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology; D010766:Phosphorylation / Q000187:drug effects; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D061207:Calcium Ionophores; C578095:IL13 protein, human; D018793:Interleukin-13; D017879:Isothiocyanates; D016328:NF-kappa B; D050778:NFATC Transcription Factors; C494003:NFATC1 protein, human; D000001:Calcimycin; C031403:benzyl isothiocyanate; D048051:p38 Mitogen-Activated Protein Kinases
keywords: benzyl isothiocyanate; interleukin-13(IL-13); mitogen-activated protein kinase (MAPK); nuclear factor of activated T cells c1(NFATc1); nuclear factor-κB (NF-κB)