title: Effects of perioperative supplementation with omega-3 fatty acids on leukotriene B₄ and leukotriene B₅ production by stimulated neutrophils in patients with colorectal cancer: a randomized, placebo-controlled intervention trial.
abstract: Omega-3 fatty acids (n-3 FA) may have beneficial clinical and immune-modulating effects in surgical patients. In a randomized, double-blind, prospective, placebo-controlled trial, 148 patients referred for elective colorectal cancer surgery received an n-3 FA-enriched oral nutritional supplement (ONS) providing 2.0 g of eicosapentaenoic acid (EPA) and 1.0 g of docosahexaenoic acid (DHA) per day or a standard ONS for seven days before surgery. On the day of operation, there was a significant increase in the production of leukotriene B5 (LTB5) (p < 0.01) and 5-hydroxyeicosapentaenoic acid (5-HEPE) (p < 0.01), a significant decrease in the production of leukotriene B4 (LTB4) (p < 0.01) and a trend for a decrease in the production of 5-hydroxyeicosatetraenoic acid (5-HETE) (p < 0.1) from stimulated neutrophils in the active group compared with controls. There was no association between LTB4 values and postoperative complications. In conclusion, oral n-3 FA exerts anti-inflammatory effects in surgical patients, without reducing the risk of postoperative complications.
authors.affiliation: Department of Surgical Gastroenterology, Aalborg University Hospital, 9000 Aalborg, Denmark. lss@rn.dk.
authors.forename: Lone S
authors.initials: LS
authors.lastname: Sorensen
authors.affiliation: Department of Surgical Gastroenterology, Aalborg University Hospital, 9000 Aalborg, Denmark. otu@rn.dk.
authors.forename: Ole
authors.initials: O
authors.lastname: Thorlacius-Ussing
authors.affiliation: Center for Nutrition and Bowel Disease, Aalborg University Hospital, 9000 Aalborg, Denmark. hhr@rn.dk.
authors.forename: Henrik H
authors.initials: HH
authors.lastname: Rasmussen
authors.affiliation: Department of Cardiology, Center for Cardiovascular Research, Aalborg University Hospital, 9000 Aalborg, Denmark. solc@rn.dk.
authors.forename: Søren
authors.initials: S
authors.lastname: Lundbye-Christensen
authors.affiliation: National Institute for Health Research Southampton Biomedical Research Center, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton SO16 6YD, UK. p.c.calder@soton.ac.uk.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Calder
authors.affiliation: NordSim, Center for Simulation, Skills Training, Science and Innovation, Aalborg University Hospital, 9000 Aalborg, Denmark. kgll@rn.dk.
authors.forename: Karen
authors.initials: K
authors.lastname: Lindorff-Larsen
authors.affiliation: Department of Cardiology, Center for Cardiovascular Research, Aalborg University Hospital, 9000 Aalborg, Denmark. ebs@rn.dk.
authors.forename: Erik B
authors.initials: EB
authors.lastname: Schmidt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000097:blood / Q000178:diet therapy* / Q000601:surgery; D019587:Dietary Supplements; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D017558:Elective Surgical Procedures; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D007975:Leukotriene B4 / Q000031:analogs & derivatives* / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects; D011183:Postoperative Complications / Q000178:diet therapy / Q000453:epidemiology; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D007975:Leukotriene B4; C040212:leukotriene B5; D015118:Eicosapentaenoic Acid; C026219:docosapentaenoic acid