title: Synthesis of aminocarbonyl N-acylhydrazones by a three-component reaction of isocyanides, hydrazonoyl chlorides, and carboxylic acids.
abstract: A novel one-pot multicomponent synthesis of α-aminocarbonyl N-acylhydrazones starting from readily available hydrazonoyl chlorides, isocyanides, and carboxylic acids is reported. The strategy exploits the ability of the carboxylic acid as a third component to suppress all competing reactions between nitrile imines and isocyanides, channeling the course of the reaction toward the formation of this novel class of compounds.
authors.affiliation: Dipartimento di Farmacia, Università di Napoli "Federico II" , via D. Montesano 49, 80131 Napoli, Italy.
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Giustiniano
authors.forename: Fiorella
authors.initials: F
authors.lastname: Meneghetti
authors.forename: Valentina
authors.initials: V
authors.lastname: Mercalli
authors.forename: Monica
authors.initials: M
authors.lastname: Varese
authors.forename: Francesco
authors.initials: F
authors.lastname: Giustiniano
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron