title: Lipid profiles and ovarian reserve status: a longitudinal study.
abstract: OBJECTIVE
  Is there any association between ovarian reserve status and lipid profile changes?
  
  
  CONCLUSIONS
  Women with lower ovarian reserve might be susceptible to higher cardiovascular risks, especially lipid disturbances, even during their reproductive life span.
  
  
  BACKGROUND
  The risk of developing cardiovascular disease (CVD) in women increases after menopause, but the association between ovarian reserve status and CVD is not known.
  
  
  METHODS
  This longitudinal study was conducted on 1015 participants of Tehran Lipid and Glucose Study, an ongoing population based cohort study with 12 years follow-up.
  
  
  METHODS
  There were 1015 women who were aged 20-50 years and met our eligibility criteria. Their ovarian reserve status was identified according to their age-specific AMH levels, calculated using the exponential-normal 3-parameter model. At the time of recruitment, 268, 233, 256 and 258 subjects were in the first, second, third and fourth quartiles of age-specific AMH, respectively. The cardiovascular risk factors of these groups were compared.
  
  
  RESULTS
  Anthropometric measurements, lipid profiles and mean systolic and diastolic blood pressures in the first and fourth AMH quartiles did not differ at the initiation of the study. Total cholesterol (TC) net changes per year were incremental in the first AMH quartile but not in the fourth quartile (P < 0.001). According to the generalized estimating equation (GEE), after adjustment for age, BMI, time interaction and menopause status, the changes across time in TC, LDL and HDL were varied according to the age-specific AMH status.
  
  
  CONCLUSIONS
  A potential limitation is that development of cardiovascular risk is a major long-term event that needs decades of follow-up from birth to death; hence further studies with longer follow-up times are needed.
  
  
  CONCLUSIONS
  We provide the insight that women with lower ovarian reserve might be susceptible to developing cardiovascular risk factors, particularly lipid disturbances, even during their reproductive life span.
  
  
  BACKGROUND
  This study was funded by Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences. The authors report no conflict of interest.
  
  
  BACKGROUND
  Not applicable.
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran ramezani@endocrine.ac.ir.
authors.forename: Fahimeh Ramezani
authors.initials: FR
authors.lastname: Tehrani
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Student of Medicine and Public Health, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Erfani
authors.affiliation: Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Cheraghi
authors.affiliation: Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Tohidi
authors.affiliation: Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D007492:Iran; D008055:Lipids / Q000097:blood*; D008137:Longitudinal Studies; D008875:Middle Aged; D065851:Ovarian Reserve; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008055:Lipids
keywords: anti-mullerian hormone; cardiovascular risk factors; generalized estimating equation; lipid profile; ovarian reserve