title: Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients.
abstract: BACKGROUND
  There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied.
  
  
  METHODS
  In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used.
  
  
  RESULTS
  Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 (LC50) value was 100 µg/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender.
  
  
  CONCLUSIONS
  This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies.
authors.affiliation: Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Sona
authors.initials: S
authors.lastname: Dalilan
authors.affiliation: Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Rezaei-Tavirani
authors.affiliation: Dept. of Biology, Faculty of Basic Sciences, Tarbiat Moallem University, Tehran, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Nabiuni
authors.affiliation: Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Heidari-Keshel
authors.affiliation: Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mona
authors.initials: M
authors.lastname: Zamanian Azodi
authors.affiliation: Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hakimeh
authors.initials: H
authors.lastname: Zali
keywords: Cell lines; Cytotoxicity; Hodgkin's lymphoma; Lavandula; Lymphocytes