title: Clinical and laboratory findings in mad honey poisoning: a single center experience.
abstract: OBJECTIVE
  This study is aimed at analyzing the demographic and clinical characteristics, as well as the hematological-biochemical parameters of patients who admitted to the hospital with the diagnosis of mad honey poisoning.
  
  
  METHODS
  A total of 16 patients who were admitted with mad honey intoxication symptoms and treated in Emergency Department of Sakarya Education and Research Hospital between January 2009 and December 2012 were included in the study. Demographic and clinical characteristics of the patients and hematological, biochemical parameters were obtained from hospital records. Heart rate, systolic and diastolic blood pressure on admission and at discharge were obtained retrospectively.
  
  
  RESULTS
  Sixteen patients (10 males and 6 females, mean age 58.5 ± 10 years, range between 41 and 79) were included in our study. Heart rate was 42 ± 6 beats/min, systolic blood pressure was 73 ± 19 mmHg, and diastolic blood pressure was 45 ± 17 mmHg on admission. In the evaluation of the patients' heart rhythms on admission to the emergency room, nine (56.3%) patients had sinus bradycardia, three (18.8%) patients had nodal rhythm, two (12.5%) patients had first degree atrioventricular block, and two (12.5%) patients had atrial fibrillation. Atropine 1.1 ± 0.4 mg and saline 1125 ± 465 ml were used to treat patients. Patients were discharged with a stable condition after an average 27.7 ± 7.2 h of follow-up. Heart rate was 75 ± 8 beats/min, systolic blood pressure was 132 ± 7 mmHg, and diastolic blood pressure was 82 ± 6 mmHg at discharge. Mortality was not observed. Hematological and biochemical parameters measured at the time of admission were within normal ranges.
  
  
  CONCLUSIONS
  Mad honey poisoning should be considered in previously healthy patients with unexplained symptoms of bradycardia, hypotension, and cardiac dysrhythmias. Therefore, diet history should carefully be obtained from the patients admitted with bradycardia and hypotension, and mad honey intoxication should also be considered in the differential diagnosis, as well as primary cardiac, neurologic, and metabolic disorders. Mad honey poisoning may be presented with life-threatening symptoms without any hematological and biochemical disorder.
authors.affiliation: Department of Internal Medicine, Findikli State Hospital, Rize, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yaylaci
authors.forename: I
authors.initials: I
authors.lastname: Kocayigit
authors.forename: E
authors.initials: E
authors.lastname: Aydin
authors.forename: A
authors.initials: A
authors.lastname: Osken
authors.forename: A B
authors.initials: AB
authors.lastname: Genc
authors.forename: M A
authors.initials: MA
authors.lastname: Cakar
authors.forename: A
authors.initials: A
authors.lastname: Tamer
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D004224:Diterpenes / Q000506:poisoning*; D005260:Female; D006722:Honey / Q000506:poisoning*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057048:Plant Nectar; D012189:Retrospective Studies; D029793:Rhododendron; D014421:Turkey
chemical_list: D004224:Diterpenes; D057048:Plant Nectar; C001311:grayanotoxin I