title: The effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis.
abstract: BACKGROUND
  Osteoporosis is a chronic disease characterized by a decrease in bone mineral density (BMD) and corruption of the microarchitectural structure of bone tissue.
  
  
  OBJECTIVE
  It was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in Oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine.
  
  
  METHODS
  Bone Mineral Density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (ALP) measurements were performed. Obtained results were compared with that of alendronate.
  
  
  RESULTS
  Oophorectomy induced osteoporosis was exacerbated by methylprednisolone. Alentronate prevented ovariectomised induced osteoporosis, but it couldn't prevent methylprednisolone +ovariectomised induced osteoporosis in rats.
  
  
  CONCLUSIONS
  Combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn't prevent osteoporosis in ovariectomised rats.
authors.affiliation: Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey.
authors.forename: Suleyman
authors.initials: S
authors.lastname: Salman
authors.affiliation: Department of Obstetrics and Gynecology, Igdir National Hospital, Igdir, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Kumbasar
authors.affiliation: Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Hacimuftuoglu
authors.affiliation: Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Ozturk
authors.affiliation: Department of Nuclear Medicine, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Bedri
authors.initials: B
authors.lastname: Seven
authors.affiliation: Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Beyzagul
authors.initials: B
authors.lastname: Polat
authors.affiliation: Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Gundogdu
authors.affiliation: Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Demirci
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.affiliation: Department of Biochemistry, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Akcay
authors.affiliation: Department of Physical Medicine and Rehabilitation, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Uslu
authors.affiliation: Department of Pathology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Ferrah
authors.initials: F
authors.lastname: Tuncel Daloglu
authors.affiliation: Department of Pharmacology, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman
keywords: Alendronate; Methylprednisolon; Metyrosine; Osteoporosis; Ovariectomy