title: Effects of vitamin E on bone remodeling in perimenopausal women: mini review.
abstract: Vitamin E is known to be the most important antioxidant in the body, protecting against the effects of toxic radicals. The main idea behind the studies on vitamin E and bone metabolism stems from the concept that oxidative stress may interfere with the bone formation activity of osteoblasts which in turn can lead to osteoporosis. This mini-review, summarizes the studies on the effects of vitamin E on bone mineral density, fracture risk, bone formation, and resorption markers in perimenopausal women. Current evidence does not the support daily use of vitamin E for protection against osteoporosis and hip fracture risk in perimenopausal women. However some benefit has been shown in some observational studies. Low vitamin E (>6.2mg/day) intake seems to be associated with an OR of 3.0 of hip fracture in current smokers. Compared with the highest quintile of alpha-tocopherol intake, the lowest quintile of intake conferred a multivariable-adjusted HR of 1.86 for hip fracture and 1.20 for any fracture. Alpha-tocopherol supplementation may alter the alpha-tocopherol/gamma-tocopherol ratio; which in turn may be associated with decreased osteoblastic activity. Interventional studies, especially randomized controlled trials (RCT), evaluating a possible causal relationship between serum vitamin E levels and BMD and hip fracture risk in perimenopausal women are needed.
authors.affiliation: Obstetrics and Gynecology, Bozova State Hospital, Sanliurfa, Turkey. Electronic address: dronur@hotmail.com.
authors.forename: Onur
authors.initials: O
authors.lastname: Guralp
mesh_terms: D015519:Bone Density; D016723:Bone Remodeling / Q000187:drug effects*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D047648:Perimenopause; D016032:Randomized Controlled Trials as Topic; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*; D016387:Women's Health
chemical_list: D014810:Vitamin E
keywords: Bone mineral density; Osteoporosis; Perimenopausal; Tocopherol; Tocotrienols; Vitamin E