title: Multiple primary malignant neoplasms of the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in a Japanese male patient: a case report.
abstract: Owing to recent advances in diagnostic and surgical techniques for cancer, a patient diagnosed with two or more neoplasms is not rare. We report on the case of a 58-year-old male with multiple primary malignant neoplasms, who suffered from three histological types of malignant neoplasm in six organs, namely the glottis, renal pelvis, urinary bladder, oral floor, prostate, and esophagus in chronological order. The first neoplasm was a squamous cell carcinoma of the glottis diagnosed in 2006. The second and third neoplasms were urothelial carcinomas of the right renal pelvis and urinary bladder, respectively, diagnosed in 2008. The remaining three neoplasms were diagnosed in 2010, namely a squamous cell carcinoma of the oral floor, an adenocarcinoma of the prostate, and a squamous cell carcinoma of the esophagus. The glottic cancer and esophageal cancer were treated by external radiation therapy. The malignant neoplasms of the oral floor and those which originated in the urinary tract were surgically resected. All neoplasms except the malignant neoplasm of the oral floor were well controlled. The patient died of cervical lymph node metastasis from the squamous cell carcinoma of the oral floor in January 2011. As far as we know, the present report is the first one on this combination of primary malignant neoplasms.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mukaiyama
authors.affiliation: Department of Urology, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyoda-ku, Tokyo 102-8798, Japan. uromotofumi@gmail.com.
authors.forename: Motofumi
authors.initials: M
authors.lastname: Suzuki
authors.forename: Teppei
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Yuta
authors.initials: Y
authors.lastname: Takeshima
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fujimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fukuhara
authors.forename: Tohru
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nishimatsu
authors.forename: Haruki
authors.initials: H
authors.lastname: Kume
authors.forename: Yukio
authors.initials: Y
authors.lastname: Homma
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000628:therapy; D017809:Fatal Outcome; D005931:Glottis / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D007682:Kidney Pelvis / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000628:therapy; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy