title: A feasibility study of an intravascular imaging antenna to image atherosclerotic plaques in Swine using 3.0 T MRI.
abstract: OBJECTIVE
  To investigate the feasibility of an intravascular imaging antenna to image abdominal aorta atherosclerotic plaque in swine using 3.0T magnetic resonance imaging (MRI).
  
  
  METHODS
  Atherosclerotic model was established in 6 swine. After 8 months, swine underwent an MR examination, which was performed using an intravascular imaging guide-wire, and images of the common iliac artery and the abdominal aorta were acquired. Intravascular ultrasound (IVUS) was performed in the right femoral artery; images at the same position as for the MR examination were obtained. The luminal border and external elastic membrane of the targeted arteries were individually drawn in the MR and IVUS images. After co-registering these images, the vessel, lumen, and vessel wall areas and the plaque burden in the same lesions imaged using different modalities were calculated and compared. The diagnostic accuracy of intravascular MR examination in delineating the vessel wall and detecting plaques were analyzed and compared using IVUS.
  
  
  RESULTS
  Compared with IVUS, good agreement was found between MRI and IVUS for delineating vessel, lumen, and vessel wall areas and plaque burden (r value: 0.98, 0.95, 0.96 and 0.91, respectively; P<0.001).
  
  
  CONCLUSIONS
  Compared with IVUS, using an intravascular imaging guide-wire to image deep seated arteries allowed determination of the vessel, lumen and vessel wall areas and plaque size and burden. This may provide an alternative method for detecting atherosclerotic plaques in the future.
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Xiaohai
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhaoqi
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
authors.forename: Zhanming
authors.initials: Z
authors.lastname: Fan
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging / Q000473:pathology*; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000473:pathology*; D015203:Reproducibility of Results; D013552:Swine; D018084:Ultrasonography, Interventional / Q000379:methods