title: Characterization of C60 fullerene complexation with antibiotic doxorubicin.
abstract: The aim of this paper was to provide the physico-chemical characterization of a key process leading to amplification of the antitumor effect of antibiotic Doxorubicin (Dox) in vivo and in vitro and occurring at the molecular level through complexation with C60 fullerene. A wide range of physico-chemical tools was used such as UV/Vis and NMR spectroscopies, atomic force microscopy, isothermal titration calorimetry and zeta-potential methods. The unusual thermodynamic behavior of the complexation process was reported, featuring unexpected and, to a certain extent, contradictory experimental observations. The explanation of the obtained results was proposed resulting in creation of a general view on aromatic drug binding with C60 fullerene. Based on these results some important practical outcomes for anticancer therapy were formulated.
authors.affiliation: Taras Shevchenko National University of Kyiv, Volodymyrska Str. 64, 01601 Kyiv, Ukraine.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Prylutskyy
authors.forename: M P
authors.initials: MP
authors.lastname: Evstigneev
authors.forename: I S
authors.initials: IS
authors.lastname: Pashkova
authors.forename: D
authors.initials: D
authors.lastname: Wyrzykowski
authors.forename: A
authors.initials: A
authors.lastname: Woziwodzka
authors.forename: G
authors.initials: G
authors.lastname: Gołuński
authors.forename: J
authors.initials: J
authors.lastname: Piosik
authors.forename: V V
authors.initials: VV
authors.lastname: Cherepanov
authors.forename: U
authors.initials: U
authors.lastname: Ritter
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D037741:Fullerenes / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D037741:Fullerenes; D004317:Doxorubicin; C069837:fullerene C60