title: Soft tissue sarcoma - A review of presentation, management and outcomes in 110 patients.
abstract: Soft tissue sarcomas are a rare group of mesenchymal tumours the treatment of which poses oncological and reconstructive challenges. Limb-salvage surgery aims to balance adequate excision margins for disease control and preservation of important structures to retain function. Reported here is the review of the Hull Plastic surgery sarcoma service over a twelve year period.
  
  
  METHODS
  We performed a review of the Hull sarcoma database over a twelve year period between 1997 and 2009. Demographic data, tumour grade, operative details complications and outcomes were recorded.
  
  
  RESULTS
  The database contained a total of 435 patients with a diagnosis of sarcoma. 110 were treated at the Plastic Surgery department over a period of 12 years between 1997 and 2009. The patients treated in our department consisted of 67 males and 43 females (median age 70 years). The most common histological type was leiomyosarcoma (n = 23). Distribution of anatomical sites affected were head and neck (n = 15), upper limb (n = 17), lower limb (n = 56), trunk (n = 22). Large tumours (greater than 8 cm) n = 30, deep tumours n = 48, and high grade (Trojani 3) n = 33. Patients were treated with surgical excision and postoperative radiotherapy in the high grade groups (2 and 3). A range of reconstructive procedures were required from skin grafting, functional muscle transfer and free flap reconstruction. Nine patients developed regional recurrence, six patients had grade 3 tumours. Three were not resectable. Fourteen patients developed distant metastases, seven had grade 3 tumours, six underwent chemotherapy, two were treated palliatively. There were twenty deaths in this group, of which sixteen were sarcoma related. Deaths in the high risk groups was seven (high grade), nine (deep tumours) and eight (tumour size >8 cm). There were six survivors from eleven in the group with all three of these risk factors.
  
  
  CONCLUSIONS
  This study summarises the management of sarcoma form one unit over a twelve year period and lends further evidence to the fact that the principles of limb-salvage surgery are applicable to a wide range of tumour-types and grades, to all patient age groups and anatomical sites with good functional results and that local and free flap reconstruction provides wound cover robust enough to withstand courses of radiotherapy. Early recurrence of high-grade disease and the development of metastasis carry a worse prognosis, especially if adjuvant therapy cannot be given.
  
  
  METHODS
  4.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Bains
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK.
authors.forename: Ashish
authors.initials: A
authors.lastname: Magdum
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK. Electronic address: wbhat@hotmail.com.
authors.forename: Waseem
authors.initials: W
authors.lastname: Bhat
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK.
authors.forename: Anu
authors.initials: A
authors.lastname: Roy
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK.
authors.forename: Alastair
authors.initials: A
authors.lastname: Platt
authors.affiliation: Department of Plastic and Reconstructive Surgery, Castle Hill Hospital, Cottingham, Hull, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Stanley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D023821:Limb Salvage; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
keywords: Management; Outcomes; Presentation; Soft tissue sarcoma