title: Liquid-phase exfoliated graphene as highly-sensitive sensor for simultaneous determination of endocrine disruptors: diethylstilbestrol and estradiol.
abstract: It is quite important to develop convenient and rapid analytical methods for trace levels of endocrine disruptors because they heavily affect health and reproduction of humans and animals. Herein, graphene was easily prepared via one-step exfoliation using N-methyl-2-pyrrolidone as solvent, and then used to construct an electrochemical sensor for highly-sensitive detection of diethylstilbestrol (DES) and estradiol (E2). On the surface of prepared graphene film, two independent and greatly-increased oxidation waves were observed at 0.28V and 0.49V for DES and E2. The remarkable signal enlargements indicated that the detection sensitivity was improved significantly. The influences of pH value, amount of graphene and accumulation time on the oxidation signals of DES and E2 were discussed. As a result, a highly-sensitive and rapid electrochemical method was newly developed for simultaneous detection of DES and E2. The values of detection limit were evaluated to be 10.87 nM and 4.9 nM for DES and E2. Additionally, this new method was successfully used in lake water samples and the accuracy was satisfactory.
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Lintong
authors.initials: L
authors.lastname: Hu
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Cheng
authors.affiliation: Ningbo Entry-exit Inspection and Quarantine Bureau of China, Ningbo 315012, China.
authors.forename: Danchao
authors.initials: D
authors.lastname: Chen
authors.affiliation: Ningbo Entry-exit Inspection and Quarantine Bureau of China, Ningbo 315012, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address: kbwu@hust.edu.cn.
authors.forename: Kangbing
authors.initials: K
authors.lastname: Wu
mesh_terms: D004054:Diethylstilbestrol / Q000032:analysis*; D052244:Endocrine Disruptors / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D004958:Estradiol / Q000032:analysis*; D006108:Graphite / Q000737:chemistry*; D059625:Liquid-Liquid Extraction; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D052244:Endocrine Disruptors; D014874:Water Pollutants, Chemical; D004958:Estradiol; D004054:Diethylstilbestrol; D006108:Graphite
keywords: Diethylstilbestrol; Electrochemical sensor; Endocrine disruptors; Estradiol; Exfoliated graphene; Highly-sensitive detection