title: Shift of the interconnection from the reaction system of paraoxonase 1 to the peroxidation reaction system of myeloperoxidase with HDL-C levels: a marker of atherosclerosis in patients with normal cholesterol levels.
abstract: BACKGROUND
  The interconnectivity of the peroxidation reaction system of myeloperoxidase (PRSM) or the reaction system of paraoxonase 1 (RSP1) with atherosclerosis remains elusive in patients with normal cholesterol levels.
  
  
  METHODS
  A total of 55 atherosclerotic patients with normal cholesterol concentrations and 45 control subjects were analyzed. Pearson's correlation was used to investigate the correlation between the levels of oxidative stress-related indices (HNE-LDL, MDA-LDL and protein carbonyls) and cholesterol indices (TC, HDL-C and LDL-C) and individual factor in RSP1 and PRSM (paraoxonase 1 activity, ionized calcium, myeloperoxidase peroxidation activity, or H2O2). Response surface regression (RSR) was used to analyze the interconnection of PRSM and RSP1 with the levels of oxidative stress-related indices and cholesterol indices.
  
  
  RESULTS
  The relation between PRSM and the increase of HNE-LDL and MDA-LDL was attributable to myeloperoxidase peroxidation activity, H2O2 concentrations and the interaction between myeloperoxidase peroxidation activity and H2O2 in the patients. PRSM preferred contribution to cholesterol levels in the cases. The interconnection of PRSM with TC was dependent on the association of PRSM with HDL-C and LDL-C.
  
  
  CONCLUSIONS
  The shift of interconnection with HDL-C levels from RSP1 to PRSM represents a marker for atherosclerotic patients with normal cholesterol levels.
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
authors.forename: Yawen
authors.initials: Y
authors.lastname: Liu
authors.affiliation: The General Hospital of Jilin Chemical Group Corporation, Jilin 132022, China.
authors.forename: Yetong
authors.initials: Y
authors.lastname: Cong
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Yan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health of Jilin University, Changchun 130021, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: The Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000031:analogs & derivatives / Q000097:blood; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood*; D011379:Prognosis; D050050:Protein Carbonylation; D014280:Triglycerides / Q000097:blood
chemical_list: D000447:Aldehydes; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C569869:malondialdehyde-low density lipoprotein, human; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D009195:Peroxidase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; C027576:4-hydroxy-2-nonenal; D002118:Calcium
keywords: Atherosclerosis; Cholesterol levels; Myeloperoxidase; Oxidative stress; Paraoxonase 1; Reaction system