title: Biophotonic effect of diode laser irradiance on tensile strength of diabetic rats.
abstract: Low-energy laser irradiance at certain wavelengths is able to stimulate the tissue bio-reaction and enhance the healing process. Collagen deposition is one of the important aspects in healing process because it can increase the strength of the skin. This study was designed to examine the biophotonic effect of irradiance on collagen production of diabetic wound in rat model. The tensile strength of skin was employed as a parameter to describe the wound. Diabetic rat models were induced by streptozotocin via intravenous injection. Skin-breaking strength was measured using an Instron tensile test machine. The experimental animals were treated with 808-nm diode laser at two different powers-0.1 and 0.5 W/cm(2)-and 30, 60, and 120 s for each session. The tensile strength was optimized after treated with high-power diode laser. The photostimulation effect was revealed by accelerated healing process and enhanced tensile strength of wound. Laser photostimulation on tensile strength in diabetic wound suggests that such therapy facilitates collagen production in diabetic wound healing.
authors.affiliation: Faculty of Science, Advanced Photonic Science Institute, Universiti Teknologi Malaysia , Johor Bahru, Johor , Malaysia.
authors.forename: Pik Suan
authors.initials: PS
authors.lastname: Lau
authors.forename: Noriah
authors.initials: N
authors.lastname: Bidin
authors.forename: Ganesan
authors.initials: G
authors.lastname: Krishnan
authors.forename: Zaleha
authors.initials: Z
authors.lastname: Nassir
authors.forename: Hazri
authors.initials: H
authors.lastname: Bahktiar
mesh_terms: D000818:Animals; D003094:Collagen / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000532:radiotherapy*; D054023:Lasers, Semiconductor / Q000009:adverse effects / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000009:adverse effects / Q000295:instrumentation*; D008297:Male; D051381:Rats; D013311:Streptozocin; D013718:Tensile Strength; D014945:Wound Healing
chemical_list: D013311:Streptozocin; D003094:Collagen
keywords: biophotonic; collagen; diabetic wound; diode laser; healing; tensile strength