title: Longitudinal gray-matter volume change in the default-mode network: utility of volume standardized with global gray-matter volume for Alzheimer's disease: a preliminary study.
abstract: Our aim was to show whether sensitivity for detecting volume changes in regional gray matter in default mode network (DMN) at converted [from mild cognitive impairment to Alzheimer's disease (from MCI to AD)] phase was improved by use of a standardized volume with global gray-matter volume. T1-weighted MR images (T1WI) of seven normal subjects and seven converted (from MCI to AD) patients were obtained from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Gray-matter images segmented with Statistical Parametric Mapping 5 were measured by the atlas-based method. We focused on five nodes of the DMN. For each phase, region of interest (ROI) volumes in the five nodes were standardized by two methods: (1) the ratio to the screening phase (S_volume) and (2) the ratio to the screening phase after both volumes were standardized by the global gray-matter volume (S_N_volume). Significant group differences between longitudinal gray-matter volume change of the converted (from MCI to AD) group and that of the normal group were found in lateral temporal cortex by S_N_volume, and precuneus by S_N_volume. These findings are useful for improving the understanding of DMN volume changes at the converted (from MCI to AD) phase.
authors.affiliation: Department of Radiological Technology, University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan, car6_pa2_rw@yahoo.co.jp.
authors.forename: Masami
authors.initials: M
authors.lastname: Goto
authors.forename: Osamu
authors.initials: O
authors.lastname: Abe
authors.forename: Shigeki
authors.initials: S
authors.lastname: Aoki
authors.forename: Naoto
authors.initials: N
authors.lastname: Hayashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohtsu
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Takao
authors.forename: Tosiaki
authors.initials: T
authors.lastname: Miyati
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Fumio
authors.initials: F
authors.lastname: Yamashita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: Harushi
authors.initials: H
authors.lastname: Mori
authors.forename: Akira
authors.initials: A
authors.lastname: Kunimatsu
authors.forename: Kenji
authors.initials: K
authors.lastname: Ino
authors.forename: Keiichi
authors.initials: K
authors.lastname: Yano
authors.forename: Kuni
authors.initials: K
authors.lastname: Ohtomo
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000033:anatomy & histology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged