title: Comparison of anticraving efficacy of right and left repetitive transcranial magnetic stimulation in alcohol dependence: a randomized double-blind study.
abstract: The objective of this study was to compare the anticraving efficacy of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the right versus left dorsolateral prefrontal cortex (DLPFC) in patients with alcohol dependence. Twenty patients with alcohol dependence syndrome were randomly allocated to receive either right or left rTMS over the right DLPFC (10 sessions at 10 Hz frequency; 20 trains per session; 4.9 seconds per train and intertrain interval 30 seconds) and were assessed on the Alcohol Craving Questionnaire (ACQ-NOW) to measure craving. Two-way repeated-measures analysis of variance for ACQ-NOW total score showed no main effect of group (F[1,18] = 0.0001 but significant main effect of time (F[1,18] = 185.91, p<0.0001, η(2) = 0.912). The interaction effect between group and time was not significant. There was significant reduction in craving scores in patients receiving either right or left rTMS with large effect size. However, there was no difference in anticraving efficacy between the two groups.
authors.affiliation: From the Dept. of Psychiatry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Orissa, India (BRM); Dept. of Psychiatry, Kasturba Medical College, Manipal, Karnataka, India (SKP); School of Psychology, Bangor University, Bangor, Wales, United Kingdom (MZUHK); Dept. of Psychiatry, Mahatma Gandhi Medical College and Research Institute, Pudduchery, India (SS); and Center for Cognitive Neurosciences, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India (SHN).
authors.forename: Biswa Ranjan
authors.initials: BR
authors.lastname: Mishra
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Praharaj
authors.forename: Mohammad Zia Ul Haq
authors.initials: MZ
authors.lastname: Katshu
authors.forename: Sukanto
authors.initials: S
authors.lastname: Sarkar
authors.forename: S Haque
authors.initials: SH
authors.lastname: Nizamie
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000523:psychology / Q000628:therapy*; D000704:Analysis of Variance; D066249:Craving / Q000502:physiology*; D004311:Double-Blind Method; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017397:Prefrontal Cortex / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D050781:Transcranial Magnetic Stimulation / Q000379:methods*