title: Rapid progression of primary cutaneous gamma-delta T-cell lymphoma with an initial indolent clinical presentation.
abstract: Primary cutaneous gamma-delta T-cell lymphoma (CGD-TCL) is a rare cutaneous T-cell lymphoma characterized by a rapidly progressive clinical course and a poor prognosis. We report a case of a 52-year-old man with a 10-year history of erythematous nodules and a rapid terminal progression diagnosed as CGD-TCL. Biopsies taken at the time of progression showed a dense lymphocytic infiltrate involving the subcutaneous adipose tissue and deep dermis. One of the biopsies displayed much more limited involvement by CGD-TCL that was nearly identical to the biopsies of the erythematous lesions 10 years before. In conclusion, this case demonstrates a case of CGD-TCL presenting as a longstanding indolent disease with a rapid terminal progression. The indolent clinical course and histological heterogeneity make diagnosing this entity during the initial stage extremely challenging. This case underscores a diverse clinical presentations and a need to consider CGD-TCL in patients showing subcutaneous lesions with an indolent clinical course.
authors.affiliation: *Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN; †InCyte Pathology, Spokane Valley, WA; and ‡Florida Cancer Specialists and Research Institute, Tampa, FL.
authors.forename: Riley E
authors.initials: RE
authors.lastname: Alexander
authors.forename: Alden R
authors.initials: AR
authors.lastname: Webb
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abuel-Haija
authors.forename: Magdalena
authors.initials: M
authors.lastname: Czader
mesh_terms: D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta