title: Association of a miRNA-137 polymorphism with schizophrenia in a Southern Chinese Han population.
abstract: Both genome wide association study (GWAS) and biochemical studies of Caucasian populations indicate a robust association between the miR-137 genetic variant rs1625579 and schizophrenia, but inconsistent results have been reported. To assay the association between this variant and schizophrenia, we genotyped 611 schizophrenic patients from Southern Chinese Han population for the risk single nucleotide polymorphism (SNP) rs1625579 using the SNaPshot technique and compared the clinical profiles of different genotypes. Additionally, a meta-analysis was performed using the combined sample groups from five case-control publications and the present study. Both the genotype and allele distributions of the rs1625579 SNP were significantly different between patients and controls (P = 0.036 and 0.026, SNP). TT genotype carriers showed slightly lower Brief Assessment of Cognition in Schizophrenia- (BACS-) derived working memory performance than G carriers (15.58 ± 9.56 versus 19.71 ± 8.18, P = 0.045). In the meta-analysis, we observed a significant association between rs1625579 and schizophrenia under different genetic models (all P < 0.05). The results of our study and meta-analysis provide convincing evidence that rs1625579 is significantly associated with schizophrenia. Furthermore, the miR-137 polymorphism influences the working memory performance of schizophrenic patients in a Chinese Han population.
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Yin
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Jiawu
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Haihong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Tao
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Lili
authors.identifier: 0000-0003-2150-3857
authors.initials: L
authors.lastname: Cui
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: You
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Juda
authors.initials: J
authors.lastname: Lin
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China.
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology* / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C545567:MIRN137 microRNA, human; D035683:MicroRNAs