title: Association of caveolin-1 genotypes with renal cell carcinoma risk in Taiwan.
abstract: The alteration of caveolin-1 (Cav-1) during carcinogenesis is of great interest and its over-expression in the tumor cell cytoplasm can predict a poor prognosis of renal cell carcinoma (RCC). However, whether the over-expression in RCC is associated with inherited polymorphism is not clear. In this hospital-based case-control study, the association of Cav-1 genotypes with RCC risk in a central Taiwanese population was investigated. Ninety-two patients with RCC and five hundred and eighty of age/gender-matched healthy controls were recruited and genotyped for six polymorphic sites at Cav-1, C521A (rs1997623), G14713A (rs3807987), G21985A (rs12672038), T28608A (rs3757733), T29107A (rs7804372), and G32124A (rs3807992). The results showed that there were statistically different distributions of the genotypic (P = 0.0170 and 0.0011) and allelic (P = 0.0033 and 0.0352) frequencies for the Cav-1 G14713A and T29107A polymorphisms among RCC patients and control subjects, respectively. As for the haplotype analysis, subjects carrying "GG/AT or GG/AA" at Cav-1 G14713A/T29107A showed a 2.06-fold increased odds ratio of RCC compared to those with GG/TT, while those of any other combinations were of unaltered odds ratios. In conclusion, this is the first report providing evidence showing that Cav-1 genotype is associated with RCC. The results showed that the G allele of the Cav-1 G14713A and the A allele of the Cav-1 T29107A are risky genetic factors for RCC susceptibility and the combinative GG/AT or GG/AA haplotype at Cav-1 G14713A/T29107A can serve as one of the RCC predictors for Taiwanese.
authors.affiliation: Graduate Institute of Clinical Medical Science, China Medical University, Taichung 40402, Taiwan, Republic of China.
authors.forename: Wen-Shin
authors.initials: WS
authors.lastname: Chang
authors.forename: Chia-Wen
authors.initials: CW
authors.lastname: Tsai
authors.forename: Shu-Ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Shyi-Wu
authors.initials: SW
authors.lastname: Wang
authors.forename: Hsi-Chin
authors.initials: HC
authors.lastname: Wu
authors.forename: Hong-Xue
authors.initials: HX
authors.lastname: Ji
authors.forename: Chih-Hsueh
authors.initials: CH
authors.lastname: Lin
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wang
authors.forename: Jou-Chun
authors.initials: JC
authors.lastname: Chou
authors.forename: Da-Tian
authors.initials: DT
authors.lastname: Bau
authors.forename: Paulus S
authors.initials: PS
authors.lastname: Wang
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000235:genetics*; D051242:Caveolin 1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1