title: Pumpkin seed oil (prostafit) or prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia.
abstract: OBJECTIVE
  To assess the efficacy of drugs containing herbal extracts in the treatment of Benign Prostatic Hyperplasia.
  
  
  METHODS
  The clinical trial study was performed in 2011-2012 at Imam Reza Hospital, Mashhad, Iran. One hundred patients with Benign Prostatic Hyperplasia were randomly divided into 2 equal groups receiving prostafit and prazosin, respectively. Quality of life and International Prostatic Symptom Score questionnaire were filled and prostate specific antigen level, uroflowmetry and prostate volume were measured at baseline, 3 and 6 months after the medication. The data was analysed using SPSS 15 and repeated measure analysis of variance.
  
  
  RESULTS
  No complications were observed during and after the treatment. International Prostatic Symptom Score had significant differences at baseline and 6 months after the treatment in both groups, specially in group 2 18 vs 22 (36% versus 44%). Quality of life was better in group 2, 25.5 vs 31.5 (51% versus 63%). prostate specific antigen level did not change after the treatment and there was no remarkable difference in either group.
  
  
  CONCLUSIONS
  Prostafit is an effective and safe treatment in Benign Prostatic Hyperplasia but not as much as prozasin.
authors.forename: Maliheh Keshvari
authors.initials: MK
authors.lastname: Shirvan
authors.forename: Mohammad Reza Darabi
authors.initials: MR
authors.lastname: Mahboob
authors.forename: Mehdi
authors.initials: M
authors.lastname: Masuminia
authors.forename: Shabnam
authors.initials: S
authors.lastname: Mohammadi
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D000368:Aged; D028464:Cucurbita / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000627:therapeutic use*; D011224:Prazosin / Q000627:therapeutic use*; D011446:Prospective Studies; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D010938:Plant Oils; D011224:Prazosin