title: Brønsted acid accelerated Pd-catalyzed direct asymmetric allylic alkylation of azlactones with simple allylic alcohols: a practical access to quaternary allylic amino acid derivatives.
abstract: A Brønsted acid accelerated Pd-catalyzed asymmetric allylic alkylation of azlactones with simple allylic alcohols under mild reaction conditions has been realized, which provides a direct and readily scalable approach for the synthesis of all-carbon quaternary allylic amino acid derivatives in excellent yields and good enantioselectivities.
authors.affiliation: State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences , Lanzhou 730000, P. R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Huameng
authors.initials: H
authors.lastname: Yang
authors.forename: Muwen
authors.initials: M
authors.lastname: Liu
authors.forename: Chungu
authors.initials: C
authors.lastname: Xia
authors.forename: Gaoxi
authors.initials: G
authors.lastname: Jiang
mesh_terms: D000478:Alkylation; D000498:Allyl Compounds / Q000737:chemistry; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D000596:Amino Acids; D001372:Aza Compounds; D007783:Lactones; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium