title: Intravitreal dexamethasone implant [Ozurdex] for the treatment of nonarteritic anterior ischaemic optic neuropathy.
abstract: OBJECTIVE
  To evaluate structural and functional outcomes of intravitreal dexamethasone implant (IDI) in three patients presenting with nonarteritic anterior ischaemic optic neuropathy.
  
  
  METHODS
  IDI was administered once in three patients. Best-corrected visual acuity (BCVA), perimetry, volume spectral-domain optical coherence tomography scan of the optic disc (ODV), retinal nerve fibre layer (RNFL) scan and visually evoked potential (VEP) measurements were assessed at baseline and after one and 3 months.
  
  
  RESULTS
  Mean BCVA was 20/100 in patient 1 (patient 2: 20/100; patient 3: 20/50) at baseline, 20/60 (patient 2: 20/400) at 1 month and 20/80 (20/400; 20/60) at 3 months. Mean deviation in perimetry developed from -4.90 dB (-22.09 dB; -8.68 dB) to -7.60 dB (-30.75 dB) and -14.23 dB (-30.59 dB; -7.17 dB). ODV and RNFL decreased during follow-up. VEP measurements showed a reduction in amplitudes during the entire observation period.
  
  
  CONCLUSIONS
  All patients showed a reduction in papilla oedema over time. A functional improvement was not observed.
authors.affiliation: Department of Ophthalmology, University of Muenster Medical Centre, Domagkstrasse 15, 48149, Muenster, Germany, Florian_alten@yahoo.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Alten
authors.forename: Christoph R
authors.initials: CR
authors.lastname: Clemens
authors.forename: Peter
authors.initials: P
authors.lastname: Heiduschka
authors.forename: Nicole
authors.initials: N
authors.lastname: Eter
mesh_terms: D001167:Arteritis / Q000188:drug therapy*; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005074:Evoked Potentials, Visual / Q000502:physiology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D018917:Optic Neuropathy, Ischemic / Q000188:drug therapy* / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014822:Vitreous Body / Q000187:drug effects*
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone