title: Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta-analysis of previous studies.
abstract: OBJECTIVE
  The objectives of this study were to analyze the association between two genetic variants (rs2200733 and rs7193343) in a Spanish population and the risk of developing atrial fibrillation, and to carry out a systematic review and meta-analysis of these associations.
  
  
  METHODS
  We performed a case-control study involving 257 case patients with atrial fibrillation and 379 controls. The case patients were individuals who had donated samples to the Spanish National DNA Bank; the controls were participating in a population-based cross-sectional study. Genotyping was carried out using a TaqMan assay. We conducted a systematic literature search in which 2 independent reviewers extracted the necessary information. The study involved a meta-analysis, a heterogeneity analysis, and a meta-regression analysis to identify the variables that explain the heterogeneity across studies.
  
  
  RESULTS
  In our population, the presence of atrial fibrillation was found to be associated with rs2200733 (odds ratio = 1.87; 95% confidence interval, 1.30-2.70), but not with rs7193343 (odds ratio = 1.18; 95% confidence interval, 0.80-1.73). In the meta-analysis, we observed an association between atrial fibrillation and both variants: odds ratio = 1.71 (95% confidence interval, 1.54-1.90) for rs2200733 and odds ratio = 1.18 (95% confidence interval, 1.11-1.25) for rs7193343. We observed heterogeneity among the studies dealing with the association between rs2200733 and atrial fibrillation, partially related to the study design, and the strength of association was greater in case-control studies (odds ratio = 1.83) than in cohort studies (odds ratio = 1.41).
  
  
  CONCLUSIONS
  Variants rs2200733 and rs7193343 are associated with a higher risk of atrial fibrillation. Case-control studies tend to overestimate the strength of association between these genetic variants and atrial fibrillation.
authors.affiliation: Grupo de Investigación en Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.
authors.forename: Albert
authors.initials: A
authors.lastname: Ferrán
authors.affiliation: Sección de Cardiología, Hospital Universitari de Sant Joan, Grup de Recerca Cardiovascular, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: José María
authors.initials: JM
authors.lastname: Alegret
authors.affiliation: Grupo de Investigación en Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain; CIBER de Epidemiología y Salud Pública, Barcelona, Spain.
authors.forename: Isaac
authors.initials: I
authors.lastname: Subirana
authors.affiliation: Sección de Cardiología, Hospital Universitari de Sant Joan, Grup de Recerca Cardiovascular, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain; Centre for Omic Sciences, Servei de Recursos Científics i Tècnics, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Gerard
authors.initials: G
authors.lastname: Aragonès
authors.affiliation: Grupo de Investigación en Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain.
authors.forename: Carla
authors.initials: C
authors.lastname: Lluis-Ganella
authors.affiliation: Servicio de Cardiología, Parc Sanitari Sant Joan de Déu, Sant Boi de Llobregat, Barcelona, Spain.
authors.forename: César
authors.initials: C
authors.lastname: Romero-Menor
authors.affiliation: Servicio de Cardiología, Hospital Municipal de Badalona, Badalona, Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Planas
authors.affiliation: Unidad de Investigación Biomédica (URB-CRB), IISPV, Hospital Universitari de Sant Joan, Universitat Rovira i Virgili, Reus, Tarragona, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Joven
authors.affiliation: Grupo de Investigación en Epidemiología y Genética Cardiovascular, IMIM (Institut Hospital del Mar d'Investigacions Mèdiques), Barcelona, Spain. Electronic address: relosua@imim.es.
authors.forename: Roberto
authors.initials: R
authors.lastname: Elosua
mesh_terms: D000328:Adult; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D018398:Homeodomain Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics* / Q000502:physiology; D013030:Spain / Q000453:epidemiology; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D000097577:Homeobox Protein PITX2
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; D000097577:Homeobox Protein PITX2; C071660:ZFHX3 protein, human
keywords: Atrial fibrillation; Fibrilación auricular; Genetics; Genética; Meta-analysis; Metanálisis; Polimorfismos; Polymorphisms