title: Risk of subsequent invasive breast cancer after a diagnosis of ductal carcinoma in situ (DCIS).
abstract: Despite surgical removal of ductal carcinoma in situ (DCIS), recurrences still occur. This retrospective cohort study evaluated the risk of invasive recurrence following surgery and investigated factors which may be predictive of recurrence. We specifically investigated invasive recurrence with respect to mode of detection of DCIS. Patients whose DCIS was detected outside of the NHS Breast Screening Programme have a higher risk of subsequent ipsilateral invasive breast cancer than those whose DCIS is detected through screening. There is no significant difference in risk of subsequent contralateral invasive recurrence according to mode of detection.
authors.affiliation: Public Health England (West Midlands), 1st Floor, 5 St. Philips Place, Colmore Row Birmingham B3 2PW, UK. Electronic address: Shan.Cheung@phe.gov.uk.
authors.forename: Shan
authors.initials: S
authors.lastname: Cheung
authors.affiliation: School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9NL, UK. Electronic address: um09m2b@leeds.ac.uk.
authors.forename: Mary E
authors.initials: ME
authors.lastname: Booth
authors.affiliation: Public Health England (West Midlands), 1st Floor, 5 St. Philips Place, Colmore Row Birmingham B3 2PW, UK. Electronic address: olive.kearins@phe.gov.uk.
authors.forename: Olive
authors.initials: O
authors.lastname: Kearins
authors.affiliation: Institute of Oncology, Level 4 - Bexley Wing, St. James Hospital, Leeds LS9 7TF, UK. Electronic address: david.dodwell@nhs.net.
authors.forename: David
authors.initials: D
authors.lastname: Dodwell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008408:Mastectomy; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016609:Neoplasms, Second Primary; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome; D006113:United Kingdom; D055815:Young Adult
keywords: Breast cancer; DCIS; NHSBSP (NHS breast screening programme); Radiotherapy; Recurrence