title: Internalization of silica nanoparticles into fluid liposomes: formation of interesting hybrid colloids.
abstract: The formation of hybrid materials consisting of membrane-coated silica nanoparticles (SiNPs) concentrated within small unilamellar vesicles (SUVs) of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) is described. They are formed by a simple self-assembly process resulting from invagination of the SiNPs into the SUVs and subsequent vesicle fusion, thereby retaining an almost constant size. This process was followed under conditions where it proceeds slowly and could be analyzed in structural detail. The finally formed well-defined SiNP-filled vesicles are long-time stable hybrid colloids and their structure is conveniently controlled by the initial mixing ratio of SiNPs and vesicles.
authors.affiliation: Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, 10623 Berlin (Germany). michael.gradzielski@tu-berlin.de.
authors.forename: Raphael
authors.initials: R
authors.lastname: Michel
authors.forename: Ellina
authors.initials: E
authors.lastname: Kesselman
authors.forename: Tobias
authors.initials: T
authors.lastname: Plostica
authors.forename: Dganit
authors.initials: D
authors.lastname: Danino
authors.forename: Michael
authors.initials: M
authors.lastname: Gradzielski
mesh_terms: D003102:Colloids / Q000737:chemistry*; D005997:Glycerylphosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry* / Q000648:ultrastructure; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010713:Phosphatidylcholines; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003102:Colloids; D008081:Liposomes; D010713:Phosphatidylcholines; D005997:Glycerylphosphorylcholine; D012822:Silicon Dioxide; C017251:1,2-oleoylphosphatidylcholine
keywords: endocytosis; hybrid colloids; internalization; liposomes; nanoparticles