title: Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure.
abstract: The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.
authors.affiliation: University of Paderborn, Department of Chemistry, Warburger Str. 100, 33 098 Paderborn, Germany.
authors.forename: Boris
authors.initials: B
authors.lastname: Schmidtgall
authors.forename: Anatol P
authors.initials: AP
authors.lastname: Spork
authors.forename: Falk
authors.initials: F
authors.lastname: Wachowius
authors.forename: Claudia
authors.initials: C
authors.lastname: Höbartner
authors.forename: Christian
authors.initials: C
authors.lastname: Ducho
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D009841:Oligonucleotides; D004247:DNA