title: Online detection of fetal acidemia during labour by testing synchronization of EEG and heart rate: a prospective study in fetal sheep.
abstract: Severe fetal acidemia during labour can result in life-lasting neurological deficits, but the timely detection of this condition is often not possible. This is because the positive predictive value (PPV) of fetal heart rate (FHR) monitoring, the mainstay of fetal health surveillance during labour, to detect concerning fetal acidemia is around 50%. In fetal sheep model of human labour, we reported that severe fetal acidemia (pH<7.00) during repetitive umbilical cord occlusions (UCOs) is preceded ∼60 minutes by the synchronization of electroencephalogram (EEG) and FHR. However, EEG and FHR are cyclic and noisy, and although the synchronization might be visually evident, it is challenging to detect automatically, a necessary condition for bedside utility. Here we present and validate a novel non-parametric statistical method to detect fetal acidemia during labour by using EEG and FHR. The underlying algorithm handles non-stationary and noisy data by recording number of abnormal episodes in both EEG and FHR. A logistic regression is then deployed to test whether these episodes are significantly related to each other. We then apply the method in a prospective study of human labour using fetal sheep model (n = 20). Our results render a PPV of 68% for detecting impending severe fetal acidemia ∼60 min prior to pH drop to less than 7.00 with 100% negative predictive value. We conclude that this method has a great potential to improve PPV for detection of fetal acidemia when it is implemented at the bedside. We outline directions for further refinement of the algorithm that will be achieved by analyzing larger data sets acquired in prospective human pilot studies.
authors.affiliation: Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada.
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology and Department of Neurosciences, CHU Sainte-Justine Research Centre, Université de Montréal, Montreal, Quebec, Canada.
authors.forename: L Daniel
authors.initials: LD
authors.lastname: Durosier
authors.affiliation: Department of Obstetrics & Gynecology, LA BioMed at Harbor-UCLA Med. Ctr., Torrance, California, United States of America.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ross
authors.affiliation: Department of Obstetrics and Gynecology, Univ. Western Ontario, London, Ontario, Canada.
authors.forename: Bryan S
authors.initials: BS
authors.lastname: Richardson
authors.affiliation: Department of Obstetrics and Gynecology and Department of Neurosciences, CHU Sainte-Justine Research Centre, Université de Montréal, Montreal, Quebec, Canada; Animal Reproduction Research Centre (CRRA), Faculty of Veterinary Medicine, Université de Montréal, Montréal, QC, Canada.
authors.forename: Martin G
authors.initials: MG
authors.lastname: Frasch
mesh_terms: D000138:Acidosis / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000706:statistics & numerical data*; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D005333:Fetus; D006340:Heart Rate, Fetal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007743:Labor, Obstetric; D016015:Logistic Models; D011237:Predictive Value of Tests; D011247:Pregnancy; D012756:Sheep