title: Separation and purification of thymopentin with molecular imprinting membrane by solid phase extraction disks.
abstract: The synthesis and performance of molecularly imprinted membranes (MIMs) as a solid phase extraction packing materials for the separation and purification of thymopentin from crude samples was described. In order to increase structural selectivity and imprinting efficiency, surface-initiated ATRP and ionic liquid (1-vinyl-3-ethyl acetate imidazolium chloride) were used to prepare molecularly imprinting membranes. The results demonstrated that solid phase extraction disks stuffed by MIMs with ionic liquids as functional monomer demonstrated high isolation and purification of performance to the thymopentin. The molecular recognition of thymopentin was analyzed by using molecular modeling software.
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China. Electronic address: wcl1982@mail.nwpu.edu.cn.
authors.forename: Chaoli
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Hu
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Guan
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Danfeng
authors.initials: D
authors.lastname: Wu
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Qian
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Science, Northwestern Polytechnical University, Xi'an 710072, China.
authors.forename: Renyuan
authors.initials: R
authors.lastname: Song
mesh_terms: D000327:Adsorption; D052578:Ionic Liquids / Q000138:chemical synthesis; D008567:Membranes, Artificial; D008958:Models, Molecular; D054802:Molecular Imprinting; D052616:Solid Phase Extraction; D016305:Thymopentin / Q000032:analysis*
chemical_list: D052578:Ionic Liquids; D008567:Membranes, Artificial; D016305:Thymopentin
keywords: Ionic liquids; Molecular simulation; Molecularly imprinting membrane; Solid phase extraction disk; Thymopentin