title: [Chemical constituents from roots of Illicium majus].
abstract: Ten compounds, including seven sesquiterpenes, two phenols and one phenylpropanoid, were isolated from the roots of Illicium majus by means of silica gel, ODS, Sephadex LH-20, and preparative HPLC. On analysis of MS and NMR spectroscopic data , their structures were established as cycloparviflorolide (1), cycloparvifloralone (2), tashironin (3), tashironin A (4), anislactone A(5), anislactone B (6), pseudomajucin (7), syringaldehyde (8), methyl-4-hydroxy-3, 5-dimethoxybenzoate (9), and (E)-3-methoxy-4,5-methylenedioxycinnamic alchol (10), respectively. Compounds 1-4 and 8-10 were first isolated from this plant. In the in vitro assays, at a concentration of 1.0 x 10(-5) mol x L(-1), compounds 5 and 6 were active against LPS induced NO production in microglia with a inhibition rate of 75.31% and 53.7%, respectively.
authors.forename: Chang-Shan
authors.initials: CS
authors.lastname: Niu
authors.forename: Ya-Dan
authors.initials: YD
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Shi-Shan
authors.initials: SS
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Liu
authors.forename: Shuang-Gang
authors.initials: SG
authors.lastname: Ma
authors.forename: Hai-Ning
authors.initials: HN
authors.lastname: Lv
authors.forename: Xia
authors.initials: X
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Xu
mesh_terms: D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000737:chemistry; D029523:Illicium / Q000737:chemistry*; D009930:Organic Chemicals / Q000032:analysis* / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D009930:Organic Chemicals