title: GST gene polymorphisms and the risk of colorectal cancer development.
abstract: Increasingly often, molecular studies of colorectal cancer focus on low penetrance genes. Among the factors potentially modifying the risk of contracting colorectal cancer is the glutathione S-transferase (GST) gene family, encoding enzymes of the glutathione transferase type. Proteins of the GST family (glutathione S-transferases) are enzymes detoxifying a wide range of hazardous substances, such as reactive oxygen species (ROS) or xenobionts. Thus, their role, among other things, is the protection of DNA against oxidative damage, which may lead to mutations, and in consequence, favour carcinogenesis. GST gene polymorphisms may affect the functioning of the encoded enzymes, exerting an effect on the level of DNA damage, and therefore may have an indirect influence on the risk of the development of cancer. At present, there are many studies available concerning GST gene polymorphisms as factors modulating the risk of developing cancer, including colorectal cancer.
authors.affiliation: Department of Surgery and Surgical Nursing, Institute of Nursing and Obstetrics, Faculty of Health Sciences, Jan Kochanowski University in Kielce, Kielce, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Klusek
authors.affiliation: Department of Surgery and Surgical Nursing, Institute of Nursing and Obstetrics, Faculty of Health Sciences, Jan Kochanowski University in Kielce, Kielce, Poland.
authors.forename: Stanisław
authors.initials: S
authors.lastname: Głuszek
authors.affiliation: Institute of Biology, Faculty of Mathematics and Natural Sciences, Jan Kochanowski University in Kielce, Kielce, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Klusek
keywords: GST genes; colorectal cancer; glutathione transferases; tumours