title: The phenomenon of multi-drug resistance in the treatment of malignant tumors.
abstract: Multi-drug resistance (MDR) is a condition when there is broad cross-resistance of cells to various agents which are different in structure and effect. Modern perceptions on mechanisms of MDR development in malignant tumors have been considered, in particular, in tre-ating breast cancer. Physiological functions and contribution to MDR development of ABC-transporter protein families have been described. The role of activation of glutathione system enzymes and apoptosis-regulating proteins in MDR formation has been shown.
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: S V
authors.initials: SV
authors.lastname: Vtorushin
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: K Y
authors.initials: KY
authors.lastname: Khristenko
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Zavyalova
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Perelmuter
authors.affiliation: Cancer Research Institute of Siberian Branch of the Russian Academy of Medical Sciences, Tomsk 634050, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Litviakov
authors.affiliation: National Research Tomsk State University, Tomsk 634050, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Denisov
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: A Y
authors.initials: AY
authors.lastname: Dulesova
authors.affiliation: State Budget Educational Institution of Higher Professional Education "Siberian State Medical University" of the Ministry of Health Care of Russia, Tomsk 634050, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Cherdyntseva
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents