title: Riociguat as a treatment regime for pulmonary arterial hypertension: a review.
abstract: Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition distinguished by elevated pressure of pulmonary arteries and increased vascular resistance. The management of patients with PAH and CTEPH has advanced rapidly over last decade but despite the progress in the treatment, the survival of suffering patients remain unsatisfactory and there is no cure for the diseases. However, surgery is not a first choice for patients. Furthermore, some patients who undergo surgery have persistent pulmonary hypertension (HTN) as a side effect after surgery. Therefore, the search for an "ideal" therapy still goes on and it lead to the approval of riociguat as a potential agent for the treatment. It acts directly on soluble guanylate cyclase, exciting the enzyme, and elevating sensitivity to lower levels of NO. Riociguat, therefore, has potential as a novel therapy for PAH and CTEPH. This review is focused on various aspects of the recently approved "riociguat" including its efficacy and safety profiles with the clinical data highlighting its importance in the present scenario.
authors.affiliation: Department of Pharmaceutical Chemistry, Indo-Soviet Friendship College of Pharmacy , Ghal Kalan, Moga, Punjab , India and.
authors.forename: Bawneet K
authors.initials: BK
authors.lastname: Narang
authors.forename: Subhajit
authors.initials: S
authors.lastname: Roy
authors.forename: Rajiv
authors.initials: R
authors.lastname: Sharma
authors.forename: Virender
authors.initials: V
authors.lastname: Singh
authors.forename: Ravindra K
authors.initials: RK
authors.lastname: Rawal
mesh_terms: D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure / Q000187:drug effects / Q000502:physiology*; D011720:Pyrazoles / Q000008:administration & dosage*; D011743:Pyrimidines / Q000008:administration & dosage*
chemical_list: D011720:Pyrazoles; D011743:Pyrimidines; C542595:riociguat
keywords: Chronic thromboembolic pulmonary hypertension; guanylate cyclase; pulmonary arterial hypertension; pulmonary endarterectomy; riociguat