title: Telomere shortening: a new prognostic factor for cardiovascular disease post-radiation exposure.
abstract: Telomere length has been proposed as a marker of mitotic cell age and as a general index of human organism aging. Telomere shortening in peripheral blood lymphocytes has been linked to cardiovascular-related morbidity and mortality. The authors investigated the potential correlation of conventional risk factors, radiation dose and telomere shortening with the development of coronary artery disease (CAD) following radiation therapy in a large cohort of Hodgkin lymphoma (HL) patients. Multivariate analysis demonstrated that hypertension and telomere length were the only independent risk factors. This is the first study in a large cohort of patients that demonstrates significant telomere shortening in patients treated by radiation therapy who developed cardiovascular disease. Telomere length appears to be an independent prognostic factor that could help determine patients at high risk of developing CAD after exposure in order to implement early detection and prevention.
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France Laboratory of Radiation Sensitivity and Radio-carcinogenesis INSERM 1030, Institut Gustave Roussy, Villejuif 94 804, France radhia.mkacher@cea.fr Radhia.mkacher@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: M'kacher
authors.affiliation: Department of Radiation Oncology, Institut Gustave Roussy, Villejuif 94 804, France.
authors.forename: T
authors.initials: T
authors.lastname: Girinsky
authors.affiliation: Laboratoire MIPS - Groupe TIIM3D, Université de Haute-Alsace, Mulhouse Cedex F-68093, France.
authors.forename: B
authors.initials: B
authors.lastname: Colicchio
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: M
authors.initials: M
authors.lastname: Ricoul
authors.affiliation: Laboratoire MIPS - Groupe TIIM3D, Université de Haute-Alsace, Mulhouse Cedex F-68093, France.
authors.forename: A
authors.initials: A
authors.lastname: Dieterlen
authors.affiliation: Department of genetics, CHU, Mulhouse Cedex 68093, France.
authors.forename: E
authors.initials: E
authors.lastname: Jeandidier
authors.affiliation: MetaSystems GmbH, Robert-Bosch-Str. 6, Altlussheim D-68804, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Heidingsfelder
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: C
authors.initials: C
authors.lastname: Cuceu
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: G
authors.initials: G
authors.lastname: Shim
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France Laboratory of Radiation Sensitivity and Radio-carcinogenesis INSERM 1030, Institut Gustave Roussy, Villejuif 94 804, France Department of Radiation Oncology, Institut Gustave Roussy, Villejuif 94 804, France Laboratoire MIPS - Groupe TIIM3D, Université de Haute-Alsace, Mulhouse Cedex F-68093, France Department of genetics, CHU, Mulhouse Cedex 68093, France MetaSystems GmbH, Robert-Bosch-Str. 6, Altlussheim D-68804, Germany Biostatistics and Epidemiology Unit, Institut Gustave Roussy, Villejuif 94 804, France Department of Radiology, Marie Lannelongue, Chatenay-Malabry 92019, France Department of hematology, Institut Gustave Roussy, Villejuif 94 804, France.
authors.forename: M
authors.initials: M
authors.lastname: Frenzel
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: A
authors.initials: A
authors.lastname: Lenain
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: L
authors.initials: L
authors.lastname: Morat
authors.affiliation: Laboratory of Radiation Sensitivity and Radio-carcinogenesis INSERM 1030, Institut Gustave Roussy, Villejuif 94 804, France Department of Radiation Oncology, Institut Gustave Roussy, Villejuif 94 804, France Laboratoire MIPS - Groupe TIIM3D, Université de Haute-Alsace, Mulhouse Cedex F-68093, France Department of genetics, CHU, Mulhouse Cedex 68093, France.
authors.forename: J
authors.initials: J
authors.lastname: Bourhis
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: W M
authors.initials: WM
authors.lastname: Hempel
authors.affiliation: Biostatistics and Epidemiology Unit, Institut Gustave Roussy, Villejuif 94 804, France.
authors.forename: S
authors.initials: S
authors.lastname: Koscielny
authors.affiliation: Department of Radiology, Marie Lannelongue, Chatenay-Malabry 92019, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Paul
authors.affiliation: Department of hematology, Institut Gustave Roussy, Villejuif 94 804, France.
authors.forename: P
authors.initials: P
authors.lastname: Carde
authors.affiliation: Laboratory of Radiobiology and Oncology, CEA, DSV/iRCM, Fontenay-aux-Roses 92265, France.
authors.forename: L
authors.initials: L
authors.lastname: Sabatier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001681:Biological Assay / Q000379:methods / Q000706:statistics & numerical data; D015984:Causality; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000235:genetics* / Q000401:mortality*; D005260:Female; D006689:Hodgkin Disease / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011874:Radiometry / Q000379:methods / Q000706:statistics & numerical data*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity; D015996:Survival Rate; D059506:Telomere Shortening / Q000235:genetics / Q000502:physiology*; D055815:Young Adult