title: Stability of [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride in solid state.
abstract: The influence of temperature and relative air humidity on the stability of two novel derivatives of daunorubicin: [(N-piperidine)methylene]daunorubicin hydrochloride and [(N-pyrrolidine)methylene]daunorubicin hydrochloride was investigated. The process of degradation was studied by using high-performance liquid chromatography with ultraviolet (UV) detection. The kinetic and thermodynamic parameters of degradation were calculated.
authors.forename: Beata
authors.initials: B
authors.lastname: Medenecka
authors.forename: Przemysław
authors.initials: P
authors.lastname: Zalewski
authors.forename: Witold
authors.initials: W
authors.lastname: Kycler
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Piekarski
authors.forename: Weronika
authors.initials: W
authors.lastname: Lemiech
authors.forename: Irena
authors.initials: I
authors.lastname: Oszczapowicz
authors.forename: Anna
authors.initials: A
authors.lastname: Jelińska
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000737:chemistry*; D004355:Drug Stability; D006813:Humidity; D007700:Kinetics; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: C000592427:((N-piperidine)methylene)daunorubicin hydrochloride; C000592428:((N-pyrrolidine)methylene)daunorubicin hydrochloride; D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin