title: Theoretical study on the impact of slip flow on chromatographic performance.
abstract: We used numerical simulations to investigate the recent observation that slip flow chromatography can obtain reduced plate heights as low as 0.032. The simulations were carried out for a 2D pillar array and a 3D face centred cubic particle stacking. We found that slip flow can only affect the mobile phase mass transfer contribution, which reduces the minimal total plate height by no more than 0.02 reduced plate height units for totally porous particles. Slip flow by itself can thus not fully explain the observed extremely low plate height values and further research is necessary to understand these results.
authors.affiliation: Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium.
authors.forename: Wim
authors.initials: W
authors.lastname: Smits
authors.affiliation: Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium.
authors.forename: Sander
authors.initials: S
authors.lastname: Deridder
authors.affiliation: Vrije Universiteit Brussel, Department of Chemical Engineering, Pleinlaan 2, 1050 Brussels, Belgium. Electronic address: gedesmet@vub.ac.be.
authors.forename: Gert
authors.initials: G
authors.lastname: Desmet
mesh_terms: D002845:Chromatography / Q000592:standards*; D003198:Computer Simulation; D004058:Diffusion; D008962:Models, Theoretical; D016062:Porosity
keywords: Computational fluid dynamics; HPLC; Slip flow