title: Feasibility and clinical utility of ultra-widefield indocyanine green angiography.
abstract: OBJECTIVE
  To evaluate the feasibility and clinical utility of a novel noncontact scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiographic system.
  
  
  METHODS
  Ultra-widefield indocyanine green angiographic images were captured using a modified Optos P200Tx that produced high-resolution images of the choroidal vasculature with up to a 200° field. Ultra-widefield indocyanine green angiography was performed on patients with a variety of retinal conditions to assess utility of this imaging technique for diagnostic purposes and disease treatment monitoring.
  
  
  RESULTS
  Ultra-widefield indocyanine green angiography was performed on 138 eyes of 69 patients. Mean age was 58 ± 16.9 years (range, 24-85 years). The most common ocular pathologies imaged included central serous chorioretinopathy (24 eyes), uveitis (various subtypes, 16 eyes), age-related macular degeneration (12 eyes), and polypoidal choroidal vasculopathy (4 eyes). In all eyes evaluated with ultra-widefield indocyanine green angiography, high-resolution images of choroidal and retinal circulation were obtained with sufficient detail out to 200° of the fundus.
  
  
  CONCLUSIONS
  In this series of 138 eyes, scanning laser ophthalmoscope-based ultra-widefield indocyanine green angiography was clinically practical and provided detailed images of both the central and peripheral choroidal circulation. Future studies are needed to refine the clinical value of this imaging modality and the significance of peripheral choroidal vascular changes in the diagnosis, monitoring, and treatment of ocular diseases.
authors.affiliation: *Department of Ophthalmology, Weill Cornell Medical College, New York, New York; †Vitreous Retina Macula Consultants of New York, New York, New York; ‡Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California; and §Department of Ophthalmology, New York University School of Medicine, New York, New York.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Klufas
authors.forename: Nicolas A
authors.initials: NA
authors.lastname: Yannuzzi
authors.forename: Claudine E
authors.initials: CE
authors.lastname: Pang
authors.forename: Sowmya
authors.initials: S
authors.lastname: Srinivas
authors.forename: Srinivas R
authors.initials: SR
authors.lastname: Sadda
authors.forename: K Bailey
authors.initials: KB
authors.lastname: Freund
authors.forename: Szilárd
authors.initials: S
authors.lastname: Kiss
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000098:blood supply*; D015862:Choroid Diseases / Q000175:diagnosis* / Q000503:physiopathology; D004396:Coloring Agents; D005240:Feasibility Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D014605:Uveitis / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green