title: Lymphangiogenesis in renal diseases: passive bystander or active participant?
abstract: Lymphatic vessels (LVs) are involved in a number of physiological and pathophysiological processes such as fluid homoeostasis, immune surveillance, and resolution of inflammation and wound healing. Lymphangiogenesis, the outgrowth of existing LVs and the formation of new ones, has received increasing attention over the past decade on account of its prominence in organ physiology and pathology, which has been enabled by the development of specific tools to study lymph vessel functions. Several studies have been devoted to renal lymphatic vasculature and lymphangiogenesis in kidney diseases, such as chronic renal transplant dysfunction, primary renal fibrotic disorders, proteinuria, diabetic nephropathy and renal inflammation. This review describes the most recent findings on lymphangiogenesis, with a specific focus on renal lymphangiogenesis and its impact on renal diseases. We suggest renal lymphatics as a possible target for therapeutic interventions in renal medicine to dampen tubulointerstitial tissue remodelling and improve renal functioning.
authors.affiliation: Department of Medicine, Division of Nephrology,University Medical Centre Groningen and University of Groningen,the Netherlands.
authors.forename: Saleh
authors.initials: S
authors.lastname: Yazdani
authors.affiliation: Department of Medicine, Division of Nephrology,University Medical Centre Groningen and University of Groningen,the Netherlands.
authors.forename: Gerjan
authors.initials: G
authors.lastname: Navis
authors.affiliation: Department of Pathology and Medical Biology, Division of Pathology,University Medical Centre Groningen and University of Groningen,the Netherlands.
authors.forename: Jan-Luuk
authors.initials: JL
authors.lastname: Hillebrands
authors.affiliation: Department of Pathology and Medical Biology, Division of Pathology,University Medical Centre Groningen and University of Groningen,the Netherlands.
authors.forename: Harry
authors.initials: H
authors.lastname: van Goor
authors.affiliation: Department of Medicine, Division of Nephrology,University Medical Centre Groningen and University of Groningen,the Netherlands.
authors.forename: Jacob
authors.initials: J
authors.lastname: van den Born
mesh_terms: D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000009:adverse effects; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000503:physiopathology*; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D014945:Wound Healing / Q000502:physiology