title: p-Toluenesulfonohydrazide as highly efficient initiator for direct C-H arylation of unactivated arenes.
abstract: p-Toluenesulfonohydrazide (PTSH) was shown to promote the highly efficient direct arylation of unactivated arenes with aryl iodides, bromides, or chlorides in the presence of potassium tert-butoxide without the assistance of any transition metals. The reaction proceeds through base-promoted homolytic aromatic substitution (BHAS) involving aryl radicals and arylradical anions as intermediates.
authors.affiliation: Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University , Nanjing 210009, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Song
authors.forename: Dongmei
authors.initials: D
authors.lastname: Zhang
authors.forename: Qihua
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yungen
authors.initials: Y
authors.lastname: Xu