title: Highly stereoselective synthesis of functionalized pyrrolo[3,2-c]quinolines via N-heterocyclic carbene catalyzed cascade sequence.
abstract: An N-heterocyclic carbene-catalyzed stereoselective Michael-Mannich-lactamization cascade reaction of tosyl-protected o-amino aromatic aldimines and 2-bromoenals for the construction of functionalized pyrrolo[3,2-c]quinolines with three consecutive stereocenters was achieved in good yields with excellent diastereo- and enantioselectivities.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, P. R. China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Yang
authors.forename: Hai-Rui
authors.initials: HR
authors.lastname: Zhang
authors.forename: Shi-Ya
authors.initials: SY
authors.lastname: Zhu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Hui
mesh_terms: D002384:Catalysis; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D011758:Pyrroles; D011804:Quinolines; C030011:carbene; D008697:Methane