title: Patient-specific analysis of displacement forces acting on fenestrated stent grafts for endovascular aneurysm repair.
abstract: Treatment options for abdominal aortic aneurysm (AAA) include highly invasive open surgical repair or minimally invasive endovascular aneurysm repair (EVAR). Despite being minimally invasive, some patients are not suitable for EVAR due to hostile AAA morphology. Fenestrated-EVAR (F-EVAR) was introduced to address these limitations of standard EVAR, where AAA is treated using a Fenestrated Stent Graft (FSG). In order to assess durability of F-EVAR, displacement forces acting on FSGs were analysed in this study, based on patient-specific geometries reconstructed from computed tomography (CT) scans. The magnitude and direction of the resultant displacement forces acting on the FSG were numerically computed using computational fluid dynamics (CFD) with a rigid wall assumption. Although displacement force arises from blood pressure and friction due to blood flow, numerical simulations elucidated that net blood pressure is the dominant contributor to the overall displacement force; as a result, time dependence of the resultant displacement force followed pressure waveform very closely. The magnitude of peak displacement force varied from 1.9N to 14.3N with a median of 7.0N. A strong positive correlation was found between inlet cross-sectional area (CSA), anterior/posterior (A/P) angle and the peak displacement force i.e. as inlet CSA or A/P angle increases, the magnitude of resultant displacement increases. This study manifests that while loads exerted by the pulsatile flow dictates the cyclic variation of the displacement force, its magnitude depends not only on blood pressure but also the FSG morphology, with the latter determining the direction of the displacement force.
authors.affiliation: Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK.
authors.forename: Harkamaljot
authors.initials: H
authors.lastname: Kandail
authors.affiliation: Department of Interventional Radiology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamady
authors.affiliation: Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, UK. Electronic address: yun.xu@imperial.ac.uk.
authors.forename: Xiao Yun
authors.initials: XY
authors.lastname: Xu
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D001794:Blood Pressure / Q000502:physiology; D001807:Blood Vessel Prosthesis; D057510:Endovascular Procedures / Q000295:instrumentation* / Q000379:methods; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D057446:Hydrodynamics; D008954:Models, Biological; D012189:Retrospective Studies; D015607:Stents; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Abdominal aortic aneurysm; Displacement force; F-EVAR