title: The safety of deep hypothermic circulatory arrest in aortic valve replacement with unclampable aorta in non-octogenarians.
abstract: OBJECTIVE
  Aortic valve replacement (AVR) in patients with severely atherosclerotic aortas (porcelain aorta) presents a significant technical challenge. Two strategies are deep hypothermic circulatory arrest (DHCA) during conventional surgery and transcatheter aortic valve replacement (TAVR). The aim of this study was to examine the outcomes in patients who underwent DHCA for AVR with a porcelain aorta to identify whether older patients are more suitable for TAVR.
  
  
  METHODS
  Between October 2004 and December 2012, 122 patients underwent AVR using DHCA for atherosclerotic aorta. Patients with concomitant valve surgery were excluded. Overall, 63.9% (78/122) were of age <80 (non-octogenarian group, NOG) and 36.1% (44/122) were >80 (octogenarian group, OG). Of the total cohort, 62.3% (76/122) had concomitant coronary artery bypass graft surgery.
  
  
  RESULTS
  The mean age for the whole cohort was 75.7 ± 8.5 years; 70.2 ± 8.1 years for the NOG and 83.4 ± 2.6 years for the OG (P = 0.001). The OG had a higher rate of preoperative renal failure (20.5%, 9/44 vs 7.7%, 6/78, P = 0.048) and trends towards a greater history of cerebrovascular disease (9.1%, 4/44 vs 1.3%, 1/78, P = 0.056), but fewer reoperations (6.8%, 3/44 vs 19.2%, 15/78, P = 0.069). Cardiopulmonary bypass time, aortic cross-clamp time and circulatory arrest time were similar between the two groups. Postoperative complication rates were similar except for permanent stroke (OG 18.2%, 8/44 vs NOG 6.4%, 5/78, P = 0.065). The overall operative mortality rate was 8.2% (10/122); however, the OG had significantly higher operative mortality compared with the NOG (15.9%, 7/44 vs 3.8%, 3/78, P = 0.035). One- and 5-year survival rates were 88.9 and 79.3% for the NOG versus 75.0 and 65.9% for the OG (P = 0.027), respectively.
  
  
  CONCLUSIONS
  Postoperative neurological events and operative mortality were, respectively, 3- and 4-fold higher in octogenarians undergoing AVR using DHCA. Such patients may represent suitable candidates for TAVR if favourable outcomes are demonstrated in patients with atherosclerotic aortas. Surgical AVR remains the standard treatment option with excellent outcomes for patients <80 years old with unclampable aortas.
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kaneko
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Neely
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Prem
authors.initials: P
authors.lastname: Shekar
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Quratulain
authors.initials: Q
authors.lastname: Javed
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Asghar
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Siobhan
authors.initials: S
authors.lastname: McGurk
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Igor
authors.initials: I
authors.lastname: Gosev
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: John G
authors.initials: JG
authors.lastname: Byrne
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Cohn
authors.affiliation: Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, MA, USA saranki@partners.org.
authors.forename: Sary F
authors.initials: SF
authors.lastname: Aranki
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001018:Aortic Diseases / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D050197:Atherosclerosis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D001900:Boston; D050792:Circulatory Arrest, Deep Hypothermia Induced / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D061205:Vascular Calcification / Q000150:complications* / Q000175:diagnosis / Q000401:mortality
keywords: Aortic valve replacement; Deep hypothermic circulatory arrest; Porcelain aorta