title: Gender differences in impact of CYP2C19 polymorphism on development of coronary artery disease.
abstract: The aim was to clarify whether CYP2C19 polymorphism is associated with the development of coronary artery disease (CAD). This study enrolled 723 patients with CAD (men 71%, 70 years) and healthy subjects undergoing a medical checkup (n = 453) as controls (men 69%, 53 years). We analyzed the incidence of CYP2C19 polymorphism and its association with the development of CAD in the absence of diabetes, dyslipidemia, and chronic kidney disease to minimize the influence of conventional coronary risk factors. In the analysis without risk factors, there was no difference in the incidence of the CYP2C19 genotype between CAD (n = 115) and control (n = 194) groups [extensive metabolizer, intermediate metabolizer, poor metabolizer (PM) in non-risk CAD: 33%, 46%, 21%, respectively; in non-risk control: 31%, 52%, 17%, respectively]. Analysis between CAD and control groups by the χ test showed that there was significant difference in distribution of CYP2C19 genotype in women alone (P = 0.025) but not in total subjects (P = 0.471) or men (P = 0.678), respectively. CYP2C19 PM was an independent predictor of CAD risk in women alone (odds ratio, 10.717; 95% confidence interval, 1.753-65.505; P = 0.010) but not in men. CYP2C19 PM status might be associated with the development of CAD as a disease susceptibility gene, especially in women.
authors.affiliation: *Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto City, Japan; and †Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto City, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Hokimoto
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tabata
authors.forename: Tomonori
authors.initials: T
authors.lastname: Akasaka
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Arima
authors.forename: Koichi
authors.initials: K
authors.lastname: Kaikita
authors.forename: Kazunori
authors.initials: K
authors.lastname: Morita
authors.forename: Naoki
authors.initials: N
authors.lastname: Kumagae
authors.forename: Kentaro
authors.initials: K
authors.lastname: Oniki
authors.forename: Kazuko
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
chemical_list: C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19