title: Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor.
abstract: The analysis of two Thorectidae sponge samples, Hyrtios sp. and Petrosaspongia sp., collected at Fiji Islands, led to the isolation of five new scalarane derivatives along with fifteen known compounds. Their structures were elucidated on the basis of NMR and MS spectroscopic data. The small library of natural scalarane derivatives was investigated for their ability to modulate the activity of trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions and the study resulted in the identification of potent inhibitors of TDP-43 protein.
authors.affiliation: Department of Pharmacy, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy. sidemari@unina.it.
authors.forename: Carmen
authors.initials: C
authors.lastname: Festa
authors.forename: Chiara
authors.initials: C
authors.lastname: Cassiano
authors.forename: Maria Valeria
authors.initials: MV
authors.lastname: D'Auria
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Monti
authors.forename: Simona
authors.initials: S
authors.lastname: De Marino
mesh_terms: D000818:Animals; D004277:DNA, Single-Stranded / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D007700:Kinetics; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D011485:Protein Binding / Q000187:drug effects; D054830:Sesterterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D018696:Neuroprotective Agents; D054830:Sesterterpenes