title: Spontaneous Regression of a Massive Sporadic Chiasmal Optic Pathway Glioma.
abstract: Optic pathway gliomas have highly variable and unpredictable natural histories, including spontaneous regression, making management decisions difficult and controversial. We report a case of substantial spontaneous regression of an optic pathway glioma involving the chiasm in a 15-month-old boy. Our case is particularly striking given the massive size at presentation with chiasmal, bilateral optic tract, and midbrain involvement, along with clinical ophthalmologic signs for which the majority of practitioners may have recommended treatment on presentation.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Noelle L
authors.initials: NL
authors.lastname: Pruzan
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Alejandra
authors.initials: A
authors.lastname: de Alba Campomanes
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
authors.forename: Ian R
authors.initials: IR
authors.lastname: Gorovoy
authors.affiliation: Department of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA creighoyt@gmail.com.
authors.forename: Creig
authors.initials: C
authors.lastname: Hoyt
mesh_terms: D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009897:Optic Chiasm / Q000473:pathology*; D020339:Optic Nerve Glioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*
keywords: natural history; optic pathway glioma; pediatric tumor