title: Toxic epidermal necrolysis in a neonate receiving fluconazole.
abstract: Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous condition, which may occur as an adverse reaction to a number of medications. The anitifungal agent, fluconazole, has been associated with TEN in limited reports, mainly in adults with HIV infection. We describe the case of a neonate with liver disease who developed TEN, presumably induced by fluconazole.
authors.affiliation: Division of Infectious Diseases, Children's Hospital and Research Center Oakland, Oakland, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Islam
authors.affiliation: Division of Infectious Diseases, Children's Hospital and Research Center Oakland, Oakland, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Singer
authors.affiliation: Division of Infectious Diseases, Children's Hospital and Research Center Oakland, Oakland, CA, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Kulhanjian
mesh_terms: D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis / Q000188:drug therapy*; D007363:Intensive Care Units, Neonatal; D008107:Liver Diseases / Q000175:diagnosis / Q000188:drug therapy; D009102:Multiple Organ Failure; D035583:Rare Diseases; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000503:physiopathology
chemical_list: D015725:Fluconazole