title: Content of IL-10 and CD4+CD210+ cells in mice with adjuvant arthritis before and after treatment with cryopreserved placental cells.
abstract: We analyzed the serum level of IL-10, blood content of CD4+СD210+ cells, and expression of IL-10 receptors in adjuvant arthritis before and after treatment with native and cryopreserved placental cells. In animals with experimental adjuvant arthritis, a negative correlation was found between the index of arthritis and IL-10 concentration (r=-0.7; p=0.03); in addition, a considerable decrease in the content of CD4+СD210+ cells and changes in the expression of IL-10 receptors on cells of the lymph nodes and spleen were demonstrated. After administration of cryopreserved DMSO-protected placental cells (in contrast to administration of cryopreserved propanedioxysacharol-protected cell suspension), the content of CD4+СD210+ cells in the spleen of animals with experimental adjuvant arthritis returned to normal.
authors.affiliation: Institute of Cryobiology and Cryomedicine Problems, National Academy of Sciences of Ukraine, Khar'kov, Ukraine, cryopato@rambler.ru.
authors.forename: E D
authors.initials: ED
authors.lastname: Lutsenko
authors.forename: N A
authors.initials: NA
authors.lastname: Bondarovich
authors.forename: A N
authors.initials: AN
authors.lastname: Gol'tsev
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001169:Arthritis, Experimental / Q000378:metabolism* / Q000628:therapy; D017690:Cell Transplantation; D015925:Cryopreservation; D005260:Female; D016753:Interleukin-10 / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D010920:Placenta / Q000166:cytology*; D011247:Pregnancy
chemical_list: D015703:Antigens, CD; D016753:Interleukin-10