title: Correlation of continuous glucose monitoring profiles with pregnancy outcomes in nondiabetic women.
abstract: OBJECTIVE
  To determine whether hyperglycemic excursions detected by continuous glucose monitoring (CGM) correlate with birth weight percentile and other pregnancy outcomes, and whether CGM correlates better with these outcomes than a single glucose value from a 1-hour glucose challenge test (GCT).
  
  
  METHODS
  This was a prospective observational study of 55 pregnant patients without preexisting diabetes, who wore a CGM device for up to 7 days, between 24 and 28 weeks' gestation. The area under the curve (AUC) of hyperglycemic excursions above various thresholds (110, 120, 130, 140, and 180 mg/dL) was calculated. These AUC values, and results from a standard 50-g GCT, were correlated with our primary outcome of birth weight percentile, and secondary outcomes of unplanned operative delivery, pregnancy complications, delivery complications, fetal complications, and neonatal complications.
  
  
  RESULTS
  A consistent correlation was seen between all AUC thresholds and birth weight percentile (r = 0.29, p < 0.05 for AUC-110, -120, -130, and -140; r = 0.25, p = 0.07 for AUC-180). This correlation was stronger than that of 1-hour oral GCT (r = -0.02, p = 0.88). There was no association between AUC values and other outcomes.
  
  
  CONCLUSIONS
  Among nondiabetic pregnant patients, hyperglycemic excursions detected by CGM show a stronger correlation to birth weight percentile than blood glucose values obtained 1-hour after a 50-g oral GCT.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Colorado Denver, Aurora, Colorado.
authors.forename: Joyce F
authors.initials: JF
authors.lastname: Sung
authors.affiliation: Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Kogut
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University, Stanford, California.
authors.forename: Henry C
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Santa Clara Valley Medical Center, San Jose, California.
authors.forename: Jana L
authors.initials: JL
authors.lastname: Mannan
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico.
authors.forename: Kasra
authors.initials: K
authors.lastname: Navabi
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: M Mark
authors.initials: MM
authors.lastname: Taslimi
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University, Stanford, California.
authors.forename: Yasser Y
authors.initials: YY
authors.lastname: El-Sayed
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis*; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000175:diagnosis; D005260:Female; D005320:Fetal Macrosomia; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000175:diagnosis*; D008991:Monitoring, Physiologic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose