title: [Epidemiology of bacillary pulmonary tuberculosis according to HIV status of patients followed in the department of infectious diseases Conakry (Guinea)].
abstract: Despite many efforts of prevention and the availability of free treatment, TB/HIV co-infection is still rampant in Guinea. The objective of this study was to describe the epidemiology of smear positive pulmonary tuberculosis according to HIV status among patients hospitalized in the infectious diseases department of Conakry University Hospital. This was a descriptive and analytical retrospective study of patient records admitted for pulmonary tuberculosis from January 2003 to December 2012. During this period, 1953 cases of tuberculosis were collected of which 346 (17.7%) were smear positive. There was a marked male predominance (59.7%). The average age was 38 ± 11 years. The majority of patients originated from the suburbs of Conakry and its surrounding prefectures (76.7%). People without profession were most represented (40.7%). A level of primary education was the most frequently reported (39.7%). Out of 325 patients tested for HIV, the serology was positive in 185 patients (56.9%). A contact with a TB patient was reported in 21.4% of HIV negative patients, and in 6.5% of the HIV-positive group (p = 0.0006). There was no difference between the two groups regarding clinical signs and symptoms. The mean CD4 count was comparable in both groups (p = 0.05). Lethality was higher among co-infected patients (30.4% against 15.56%; p = 0.00037). Strengthening the prevention of TB among PLWHA by the administration of isoniazide seems necessary and warrants further study on this subject in Guinea.
authors.affiliation: Service des maladies infectieuses et tropicales de l'Hôpital National Donka, Conakry, République de Guinée, fatraore01@gmail.com.
authors.forename: F A
authors.initials: FA
authors.lastname: Traoré
authors.forename: F B
authors.initials: FB
authors.lastname: Sako
authors.forename: D
authors.initials: D
authors.lastname: Sylla
authors.forename: M
authors.initials: M
authors.lastname: Bangoura
authors.forename: D O
authors.initials: DO
authors.lastname: Kpamy
authors.forename: M
authors.initials: M
authors.lastname: Traoré
authors.forename: M
authors.initials: M
authors.lastname: Doumbouya
authors.forename: I
authors.initials: I
authors.lastname: Sangare
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015897:Comorbidity; D005260:Female; D016701:Guinea / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D006748:Hospital Departments / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D055552:Infectious Disease Medicine; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid