title: [Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography combined with inflammatory factors for detecting atherosclerotic plaques in rabbits].
abstract: OBJECTIVE
  To investigate the feasibility of Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance angiography (USPIO-MRA) combined with interleukin-6 (IL-6) and IL-10 detection for detecting atherosclerotic plaques in rabbits.
  
  
  METHODS
  Twenty-four normal male rabbits were randomly assigned (n=8) into group A with atherosclerosis induced by damaging the aortic tunica intima with Foley's tube in combination with a high fat diet, group B with a high fat diet, and group C without any intervention. At week 12, plain and USPIO-MRA was performed in all the 24 rabbits and the results were compared with pathological examinations; blood samples were collected from the ear vein to examine blood lipids and levels of IL-6 and IL-10.
  
  
  RESULTS
  The rabbits in groups A and B showed significantly different IL-6 levels (167 ± 21.3 vs 116 ± 14.3 pg/ml, P<0.05) but comparable blood lipids and IL-10 levels (P>0.05). The levels of IL-6, IL-10, TC, TG, and LDL, but not HDL, differed significantly between groups A and C and between groups B and C (P<0.01). Continuous MRA scan showed significantly different signal-to-noise ratios (SNR) between the 3 groups.
  
  
  CONCLUSIONS
  USPIO-MRA combined with IL-6 and IL-10 detection is feasible in detecting atherosclerotic plaques in rabbits.
authors.affiliation: Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. E-mail: ligxin@163.com.
authors.forename: Gongxin
authors.initials: G
authors.lastname: Li
authors.forename: Luzhao
authors.initials: L
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Wen
authors.forename: Fanheng
authors.initials: F
authors.lastname: Huang
authors.forename: Liheng
authors.initials: L
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Yijun
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000818:Animals; D050197:Atherosclerosis; D003287:Contrast Media; D003911:Dextrans; D016753:Interleukin-10 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D018810:Magnetic Resonance Angiography; D058185:Magnetite Nanoparticles; D008297:Male; D058226:Plaque, Atherosclerotic / Q000175:diagnosis*; D011817:Rabbits
chemical_list: D003287:Contrast Media; D003911:Dextrans; D015850:Interleukin-6; D058185:Magnetite Nanoparticles; C097921:ferumoxtran-10; D016753:Interleukin-10