title: Urine 3-hydroxykynurenine is higher during the postovulatory phase than in the preovulatory phase indicating a higher vitamin B6 requirement.
abstract: The relationship between l-tryptophan to nicotinamide metabolism and the menstrual cycle of Japanese women was investigated. Nine metabolism intermediates from urine samples collected during the preovulatory and postovulatory phases were measured. Only urine 3-hydroxykynurenine was higher in the postovulatory phase than in the preovulatory phase. This increase in 3-hydroxykynurenine suggests a decreased reaction of 3-hydroxykynurenine → 3-hydroxyanthranilic acid catalyzed by kynureninase, a vitamin B6 enzyme.
authors.affiliation: a Department of Nutrition, School of Human Nutrition , The University of Shiga Prefecture , Shiga 522-8533 , Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
mesh_terms: D000328:Adult; D005260:Female; D005498:Follicular Phase / Q000378:metabolism / Q000652:urine; D006801:Humans; D007737:Kynurenine / Q000031:analogs & derivatives* / Q000652:urine; D008183:Luteal Phase / Q000378:metabolism* / Q000652:urine*; D025101:Vitamin B 6 / Q000378:metabolism*; D055815:Young Adult
chemical_list: C005045:3-hydroxykynurenine; D007737:Kynurenine; D025101:Vitamin B 6
keywords: menstrual cycle; nicotinamide; ovulatory phase; tryptophan; vitamin B6