title: Success of continuous veno-venous hemodiafiltration treatment in children monitored in the intensive care units.
abstract: BACKGROUND
  As intensive care units (ICU) have improved, presence of multiple-organ dysfunctions in majority of patients with acute renal failure (ARF) has become clearer. To facilitate multi-organ support, continuous renal replacement therapy (CRRT) techniques have been developed. This study is the one that reports the experience on children including newborns receiving CRRT monitored in ICU.
  
  
  METHODS
  The study was performed retrospectively in children who had Continuous Veno- Venous Hemodiafiltration (CVVHDF) as a CRRT modality in ICU. Clinical data, primary cause, consultation time, duration and initiation time of CVVHDF were recorded. Patients were classified as cardiac and non-cardiac in respect to primary dysfunction. Stage of renal failure was evaluated according to pRIFLE criteria. Outcome was identified as primary and secondary. Primary outcome was accepted as the composite correction of uremia and metabolic parameters, and regression of fluid overload, while secondary outcomes were assessed as improvement of hemodynamic instability and survival.
  
  
  RESULTS
  A total of 36 patients' files were scanned. There were 10 cases in cardiac group and 26 cases in non-cardiac group. There were statistically better differences between primary and secondary outcome rates of cardiac cases. Although there was no difference between cardiac and non-cardiac cases in terms of primary outcome, secondary outcome was statistically significant. Timing of consultation and CVVHDF was not found to have an effect on the outcome.
  
  
  CONCLUSIONS
  Our results indicated that CVVHDF treatment was successful even in cardiac patients with high mortality and in patients at their later stage of ARF.
authors.affiliation: Denizli State Hospital , Denizli , Turkey .
authors.forename: Orhan Deniz
authors.initials: OD
authors.lastname: Kara
authors.forename: Nida
authors.initials: N
authors.lastname: Dincel
authors.forename: Ipek
authors.initials: I
authors.lastname: Kaplan Bulut
authors.forename: Ebru
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Kadriye
authors.initials: K
authors.lastname: Ozdemir
authors.forename: Gozde
authors.initials: G
authors.lastname: Gozuoğlu
authors.forename: Hasan
authors.initials: H
authors.lastname: Bicer
authors.forename: Sevgi
authors.initials: S
authors.lastname: Mir
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D015278:Intensive Care Units, Pediatric; D008297:Male; D008991:Monitoring, Physiologic; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014511:Uremia
keywords: Children; renal replacement therapy; survival; veno-venous hemodiafiltration