title: Mitochondrial toxicity in human pregnancy: an update on clinical and experimental approaches in the last 10 years.
abstract: Mitochondrial toxicity can be one of the most dreadful consequences of exposure to a wide range of external agents including pathogens, therapeutic agents, abuse drugs, toxic gases and other harmful chemical substances. However, little is known about the effects of mitochondrial toxicity on pregnant women exposed to these agents that may exert transplacental activity and condition fetal remodeling. It has been hypothesized that mitochondrial toxicity may be involved in some adverse obstetric outcomes. In the present study, we investigated the association between exposure to mitochondrial toxic agents and pathologic conditions ranging from fertility defects, detrimental fetal development and impaired newborn health due to intra-uterine exposure. We have reviewed data from studies in human subjects to propose mechanisms of mitochondrial toxicity that could be associated with the symptoms present in both exposed pregnant and fetal patients. Since some therapeutic interventions or accidental exposure cannot be avoided, further research is needed to gain insight into the molecular pathways leading to mitochondrial toxicity during pregnancy. The ultimate objective of these studies should be to reduce the mitochondrial toxicity of these agents and establish biomarkers for gestational monitoring of harmful effects.
authors.affiliation: Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS-Faculty of Medicine-University of Barcelona, Internal Medicine Service-Hospital Clínic of Barcelona, Barcelona 08036, Spain. cmoren1@clinic.ub.es.
authors.forename: Constanza
authors.initials: C
authors.lastname: Morén
authors.affiliation: Centro de Investigación Biomédica en Red (CIBER) de Enfermedades Raras, CIBERER, Valencia 46010, Spain. ashernan@clinic.ub.es.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernández
authors.affiliation: Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS-Faculty of Medicine-University of Barcelona, Internal Medicine Service-Hospital Clínic of Barcelona, Barcelona 08036, Spain. ashernan@clinic.ub.es.
authors.forename: Mariona
authors.initials: M
authors.lastname: Guitart-Mampel
authors.affiliation: Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS-Faculty of Medicine-University of Barcelona, Internal Medicine Service-Hospital Clínic of Barcelona, Barcelona 08036, Spain. ashernan@clinic.ub.es.
authors.forename: Glòria
authors.initials: G
authors.lastname: Garrabou
mesh_terms: D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D005333:Fetus; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D028361:Mitochondrial Diseases / Q000139:chemically induced*; D011247:Pregnancy
chemical_list: D004785:Environmental Pollutants