title: Colloids containing gadolinium-capped gold nanoparticles as high relaxivity dual-modality contrast agents for CT and MRI.
abstract: A type of novel macromolecular colloid was prepared from gadolinium-based poly(l-succinimide) and gold nanoparticles (GNPs) with Au-S covalent bonds. The colloid displayed improved stability in aqueous media and regular arrays in partial region. Moreover, these materials enhanced the contrast 9 times more than that of the corresponding uncoated Au compound when the Au mass content was only 0.15%. Therefore, these materials might have potential as dual-modality contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT).
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. China.
authors.forename: ChengCai
authors.initials: C
authors.lastname: Zeng
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. China.
authors.forename: XiaoNi
authors.initials: X
authors.lastname: Shi
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, Zhejiang Province, P. R. China. Electronic address: zwl@wzu.edu.cn.
authors.forename: WeiLu
authors.initials: W
authors.lastname: Zhang
mesh_terms: D003102:Colloids / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry*
chemical_list: D003102:Colloids; D003287:Contrast Media; D006046:Gold; D005682:Gadolinium
keywords: Colloid; Contrast agents; Gadolinium; Gold nanoparticles; MRI/CT dual-modality