title: Quantitative apparent diffusion coefficient (ADC) values as an imaging biomarker for fibrosis in pediatric Crohn's disease: preliminary experience.
abstract: OBJECTIVE
  To compare histopathology with ADC values in strictured bowel segments in pediatric patients with known Crohn's disease and surgical bowel resection.
  
  
  METHODS
  Magnetic resonance enterography (MRE) images of 14 subjects with Crohn's disease who had surgical bowel resection for strictures were retrospectively reviewed. Five of 14 subjects had DWI (b=0, 500, 1000) sequences included in the MRE study. ADC measurements were made by placing ROI's in the strictured bowel wall and compared to full-thickness histologic analysis of resected specimens. ADC values were also compared to control ADC measurements (in normal and inflamed-nonstenotic bowel segments) as well as the mean ADC values of Crohn's patients published in the literature.
  
  
  RESULTS
  All five subjects had transmural fibrosis. The mean ADC value with b = 500 was 0.92 ± 0.10 × 10(-3) mm(2)/s and with b = 1000 was 0.8 ± 0.05 × 10(-3) mm(2)/s. There was a significant difference in ADC values between strictures and inflamed-nonstenotic segments (p=0.0143) and between normal and diseased bowel segments (p=0.009-0.0143).
  
  
  CONCLUSIONS
  Quantitative ADC measures of transmural fibrosis are lower compared to the reported values of inflammation in Crohn's disease. To our knowledge, this is the first pediatric pilot study to investigate the correlation of quantitative DWI with histology of surgical specimens in pediatric patients with Crohn's disease. Our results are comparable to a recently published study in adult Crohn's patients showing a significant correlation between a decrease in ADC values and fibrosis.
authors.affiliation: Department of Radiology, Weill Cornell Medical College, New York Presbyterian Hospital, 525 E 68th St., New York, NY, 1006, USA, ark2011@med.cornell.edu.
authors.forename: A
authors.initials: A
authors.lastname: Kovanlikaya
authors.forename: D
authors.initials: D
authors.lastname: Beneck
authors.forename: M
authors.initials: M
authors.lastname: Rose
authors.forename: P
authors.initials: P
authors.lastname: Renjen
authors.forename: A
authors.initials: A
authors.lastname: Dunning
authors.forename: A
authors.initials: A
authors.lastname: Solomon
authors.forename: R
authors.initials: R
authors.lastname: Sockolow
authors.forename: P W
authors.initials: PW
authors.lastname: Brill
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D003251:Constriction, Pathologic / Q000601:surgery; D003424:Crohn Disease / Q000150:complications / Q000473:pathology* / Q000601:surgery; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007249:Inflammation / Q000150:complications / Q000473:pathology; D007415:Intestinal Obstruction / Q000150:complications / Q000473:pathology / Q000601:surgery; D007422:Intestines / Q000473:pathology / Q000601:surgery / Q000648:ultrastructure; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers