title: Structure of pravastatin and its complex with sodium dodecyl sulfate micelles studied by NMR spectroscopy.
abstract: The aim of this work was to study the mechanisms of interaction between pravastatin and cell membranes using model membranes (sodium dodecyl sulfate micelles) by nuclear magnetic resonance spectroscopy methods. On the basis of the nuclear magnetic resonance experiments, it was established that pravastatin can form intermolecular complexes with sodium dodecyl sulfate micelles by the interaction of its hydrophilic groups with the polar surface of the micelle. Conformational features of pravastatin molecule were also studied.
authors.affiliation: Institute of Physics, Kazan Federal University, 420008, Kazan, Russia.
authors.forename: L F
authors.initials: LF
authors.lastname: Galiullina
authors.forename: I Z
authors.initials: IZ
authors.lastname: Rakhmatullin
authors.forename: E A
authors.initials: EA
authors.lastname: Klochkova
authors.forename: A V
authors.initials: AV
authors.lastname: Aganov
authors.forename: V V
authors.initials: VV
authors.lastname: Klochkov
mesh_terms: D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008823:Micelles; D017035:Pravastatin / Q000737:chemistry*; D011487:Protein Conformation; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*
chemical_list: D008823:Micelles; D012967:Sodium Dodecyl Sulfate; D017035:Pravastatin
keywords: NMR spectroscopy; biophysical models; complexation; micelle; nuclear overhauser effect; pravastatin; sodium dodecyl sulfate; surfactants