title: Considering relatives when assessing the evidential strength of mixed DNA profiles.
abstract: Sophisticated methods of DNA profile interpretation have enabled scientists to calculate weights for genotype sets proposed to explain some observed data. Using standard formulae these weights can be incorporated into an LR calculation that considers two competing propositions. We demonstrate here how consideration of relatedness to the person of interest can be incorporated into a LR calculation and how the same calculation can be used for familial searches of complex mixtures. We provide a general formula that can be used in semi or fully automated methods of calculation and demonstrate their use by working through an example.
authors.affiliation: Forensic Science South Australia, 21 Divett Place, Adelaide, SA 5000, Australia; School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia. Electronic address: Duncan.Taylor@sa.gov.au.
authors.forename: Duncan
authors.initials: D
authors.lastname: Taylor
authors.affiliation: ESR, Private Bag 92021, Auckland 1142, New Zealand.
authors.forename: Jo-Anne
authors.initials: JA
authors.lastname: Bright
authors.affiliation: ESR, Private Bag 92021, Auckland 1142, New Zealand.
authors.forename: John
authors.initials: J
authors.lastname: Buckleton
mesh_terms: D004247:DNA / Q000235:genetics*; D016172:DNA Fingerprinting; D005190:Family; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008957:Models, Genetic; D010375:Pedigree
chemical_list: D004247:DNA
keywords: Continuous model; DNA profile interpretation; Likelihood ratio; Mixtures; Relatives; STRmix