title: p53 and the PWWP domain containing effector proteins in chromatin damage repair.
abstract: In eukaryotic cells, DNA damage repair occurs on a template DNA that is organized with histones to form nucleosomes and chromatin structures. As such, chromatin plays an important role in DNA damage repair. In this review, we will use "chromatin damage repair" as a framework and highlight recent progress in understanding the role of chromatin, chromatin modifiers, chromatin binding effectors (e.g., the PWWP domain proteins), and the p53 tumor suppressor. We view chromatin as an active participant during DNA damage repair.
authors.affiliation: Graduate Program in Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, 16802 USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Hu
authors.affiliation: Center for Eukaryotic Gene Regulation, Pennsylvania State University, University Park, PA, 16802 USA.
authors.forename: Yanming
authors.initials: Y
authors.lastname: Wang