title: Resveratrol prevents social deficits in animal model of autism induced by valproic acid.
abstract: Autism spectrum disorders (ASD) involve a complex interplay of both genetic and environmental risk factors, such as prenatal exposure to valproic acid (VPA). Considering the neuroprotective, antioxidant and anti-inflammatory effects of resveratrol (RSV), we investigated the influence of prenatal RSV treatment on social behaviors of a rodent model of autism induced by prenatal exposure to VPA. In the three-chambered apparatus test, the VPA group showed a reduced place preference conditioned by conspecific and no preference between exploring a wire-cage or a rat enclosed inside a wire cage, revealing sociability impairments. Prenatal administration of RSV prevented the VPA-induced social impairments evaluated in this study. A bioinformatics analysis was used to discard possible molecular interactions between VPA and RSV during administration. The interaction energy between RSV and VPA is weak and highly unstable, suggesting cellular effects instead of a single chemical process. In summary, the present study highlights a promising experimental strategy to evaluate new molecular targets possibly involved in the etiology of autism and developmental alterations implicated in neural and behavioral impairments in ASD.
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: victoriobambini@gmail.com.
authors.forename: Victorio
authors.initials: V
authors.lastname: Bambini-Junior
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Geancarlo
authors.initials: G
authors.lastname: Zanatta
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Della Flora Nunes
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Mueller de Melo
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Marcus
authors.initials: M
authors.lastname: Michels
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Mellanie
authors.initials: M
authors.lastname: Fontes-Dutra
authors.affiliation: Department of Physics, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Valder
authors.initials: V
authors.lastname: Nogueira Freire
authors.affiliation: Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Child Neurology Unit, Clinical Hospital of Porto Alegre (HCPA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Rudimar
authors.initials: R
authors.lastname: Riesgo
authors.affiliation: Research Group in Neuroglial Plasticity at the Department of Biochemistry, Institute of Health's Basic Science, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil; Translational Research Group in Autism Spectrum Disorders (GETTEA), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Carmem
authors.initials: C
authors.lastname: Gottfried
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001321:Autistic Disorder / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D008297:Male; D018811:Maternal Exposure; D056004:Molecular Dynamics Simulation; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000188:drug therapy / Q000523:psychology; D017208:Rats, Wistar; D000077185:Resveratrol; D066107:Social Skills; D013267:Stilbenes / Q000627:therapeutic use*; D014635:Valproic Acid / Q000009:adverse effects*
chemical_list: D000893:Anti-Inflammatory Agents; D013267:Stilbenes; D014635:Valproic Acid; D000077185:Resveratrol
keywords: Animal model; Autism spectrum disorder; Behavior; Resveratrol; Valproate