title: [Idenfication of microRNAs profiles in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To filtrate and prove the different microRNAs (miRs) profiles in nasopharyngeal carcinoma.
  
  
  METHODS
  Screening the different expressions of miRs between nasopharyngeal carcinoma and the inflammatory tissues by the application of expression profiling of chip high-throughput and large-scale microarray analysis. Then we used RT-QPCR technology to prove the accuracy of screening results.
  
  
  RESULTS
  There were significant expression differences of miRs between nasopharyngeal carcinoma and the control tissues, 144 human miRs had 2 or more fold the difference ratio. Compared with the inflammatory tissues, we have found that miRs-34b, miRs-449b and miRs-7-1 significantly low expressed in nasopharyngeal carcinoma, yet miRs-125b, miRs-184, miRs-196b, miRs-205 and miRs-24-1 expressed high. The results were consistent with the microarray analysis.
  
  
  CONCLUSIONS
  The difference expressed miRs might be closely related to the process of nasopharyngeal carcinoma, and the research on miRs profiles maybe provide a powerful target basis for early diagnosis and therapy of nasopharyngeal carcinoma.
authors.forename: Guohui
authors.initials: G
authors.lastname: Nie
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Yilin
authors.initials: Y
authors.lastname: Lin
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Yu
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Li
authors.forename: Hongfang
authors.initials: H
authors.lastname: Duan
authors.forename: Ruijing
authors.initials: R
authors.lastname: Lu
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Hongyi
authors.initials: H
authors.lastname: Hu
authors.forename: Xueshuang
authors.initials: X
authors.lastname: Mei
mesh_terms: D002277:Carcinoma; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D035683:MicroRNAs