title: Protein 4.1R attenuates autoreactivity in experimental autoimmune encephalomyelitis by suppressing CD4(+) T cell activation.
abstract: Immune synapse components contribute to multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) pathogenesis as they play important role in autoreactive T cell activation. Protein 4.1R, a red cell membrane cytoskeletal protein, recently was identified as an important component of immunological synapse (IS) and acted as the negative regulator of CD4(+) T cell activation. However, the pathological role of 4.1R in the MS/EAE pathogenesis is still not elucidated. In this study, we investigated the potential role of protein 4.1R in pathologic processes of EAE by using 4.1R knockout mouse model. Our results suggest that 4.1R can prevent pathogenic autoimmunity in MS/EAE progression by suppressing the CD4(+) T cell activation.
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: liux@zzu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: 516721749@qq.com.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Henan Academy of Medical and Pharmaceutical Sciences, Zhengzhou University, 40 University Road, Zhengzhou 450052, PR China. Electronic address: jizhenyu@zzu.edu.cn.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Ji
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: 362237729@qq.com.
authors.forename: Guo
authors.initials: G
authors.lastname: Fu
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: 719788593@qq.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Nanyang Pukang Pharmaceutical Corporation, Ltd., 143 Industrial Road, Nanyang 473053, PR China. Electronic address: tougaobeiyong@sina.cn.
authors.forename: Xiaobei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Nanyang Pukang Pharmaceutical Corporation, Ltd., 143 Industrial Road, Nanyang 473053, PR China. Electronic address: tgbyfb@sina.cn.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Shi
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: tingwang@zzu.edu.cn.
authors.forename: Ting
authors.initials: T
authors.lastname: Wang
authors.affiliation: School of Life Sciences, Zhengzhou University, 100 Science Road, Zhengzhou 450001, PR China. Electronic address: qzkang@zzu.edu.cn.
authors.forename: Qiaozhen
authors.initials: Q
authors.lastname: Kang
mesh_terms: D000818:Animals; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D002478:Cells, Cultured; D003598:Cytoskeletal Proteins / Q000172:deficiency / Q000378:metabolism*; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000172:deficiency / Q000378:metabolism*; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
chemical_list: D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; C000595222:protein 4.1R , mouse
keywords: Autoimmunity disease; CD4(+) T cell; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Protein 4.1R