title: MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis.
abstract: Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarthritis. Due to its outstanding characteristics, MicroRNA has been considered as an efficient target in treating diseases. In this review, we will discuss a new insight focusing on the roles of microRNA in the progression of osteoarthritis-induced by diabetes, especially type II diabetes mellitus.
authors.affiliation: Department of Orthopedics, Huashan Hospital, Fudan University, 12 Urumqi Road, Shanghai, 200040, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Jingsheng
authors.forename: Wei
authors.initials: W
authors.lastname: Yibing
authors.forename: Xia
authors.initials: X
authors.lastname: Jun
authors.forename: Wang
authors.initials: W
authors.lastname: Siqun
authors.forename: Wu
authors.initials: W
authors.lastname: Jianguo
authors.forename: Chen
authors.initials: C
authors.lastname: Feiyan
authors.forename: Huang
authors.initials: H
authors.lastname: Gangyong
authors.forename: Chen
authors.initials: C
authors.lastname: Jie
mesh_terms: D000818:Animals; D002356:Cartilage / Q000473:pathology*; D048909:Diabetes Complications / Q000235:genetics* / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D018450:Disease Progression; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D010003:Osteoarthritis / Q000150:complications / Q000235:genetics* / Q000378:metabolism*; D011379:Prognosis; D011788:Quality of Life
chemical_list: C542542:MIRN146 microRNA, human; C522425:MIRN34 microRNA, human; D035683:MicroRNAs; C544302:Mirn140 microRNA, human