title: [Advance in studies on toxicity of aristolochic acid and analysis on risk factors].
abstract: The renal toxicity and mutagenicity of aristolochic acid (AA) as well as its carcinogenicity on upper urinary tract transitional epithelial cells have been widely known. Since 2003, drug regulatory departments have successively cancelled the quality standards for AA-containing medicines such as Aristolochiae Radix, Aristolochiae Manshuriensis Caulis and Aristolchiae Fangchi Radix, and adopted measures for strengthening regulation and revising package insert or quality standards for other AA-containing medicines, including Aristolochia Cinnabarina Radix, Aristolochiae Fructus, Aristolochiae Mollissimae Herba, in order to control its safety risk. In recent years, domestic and foreign studies on AA have mainly involved action mechanism and clinical performance of AA toxicity, early-stage diagnosis and treatment method. In this paper, authors gave a brief summary and evaluation on risk factors for using AA-containing medicines, and offered measures and suggestions for preventing and controlling AA toxicity.
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Song
authors.forename: Jing-Tian
authors.initials: JT
authors.lastname: Ren
authors.forename: Le
authors.initials: L
authors.lastname: Yang
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Guo
authors.forename: Xiao-Xi
authors.initials: XX
authors.lastname: Du
mesh_terms: D000818:Animals; D030022:Aristolochia / Q000009:adverse effects / Q000737:chemistry*; D034341:Aristolochic Acids / Q000032:analysis / Q000627:therapeutic use / Q000633:toxicity*; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans
chemical_list: D034341:Aristolochic Acids; D004365:Drugs, Chinese Herbal; C000228:aristolochic acid I