title: Single nucleotide polymorphisms of vitamin D binding protein, vitamin D receptor and retinoid X receptor alpha genes and response to hepatitis B vaccination in renal replacement therapy patients.
abstract: OBJECTIVE
  Vitamin D (VD) was recently associated with response to hepatitis B vaccination in chronic kidney disease. We investigated whether polymorphisms in VD binding protein (GC), VD receptor (VDR) and retinoid X receptor α (RXRA) genes were associated with response to hepatitis B vaccination in renal replacement therapy (RRT) patients.
  
  
  METHODS
  The study was carried out on 692 responders and 223 non-responders.
  
  
  RESULTS
  After adjustment for gender, age at the RRT onset, RRT vintage, chronic glomerulonephritis as a cause of renal failure and mean serum parathyroid hormone level, VDR rs1544410 polymorphism was the only one significantly associated with response to hepatitis B vaccination: homozygotes AA (adjusted OR 1.50, 95% CI: 1.17-1.94, p = 0.002) had higher risk to be non-responders than GG homozygotes.
  
  
  CONCLUSIONS
  The VDR rs1544410 AA genotype may play a negative role (but not as an independent factor) in determining response to hepatitis B vaccination in RRT patients.
authors.affiliation: Chair and Department of Nephrology, Transplantology and Internal Diseases, Poznań University of Medical Sciences (PUMS), 49 Przybyszewskiego Blvd., 60-355 Poznań, Poland.
authors.forename: Alicja E
authors.initials: AE
authors.lastname: Grzegorzewska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Jodłowska
authors.forename: Adrianna
authors.initials: A
authors.lastname: Mostowska
authors.forename: Anna
authors.initials: A
authors.lastname: Sowińska
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005787:Gene Frequency; D006509:Hepatitis B / Q000517:prevention & control*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics*; D051437:Renal Insufficiency / Q000276:immunology* / Q000628:therapy; D017582:Renal Replacement Therapy; D047490:Retinoid X Receptor alpha / Q000235:genetics*; D017211:Treatment Failure; D014809:Vitamin D-Binding Protein / Q000235:genetics*; D055815:Young Adult
chemical_list: D017325:Hepatitis B Vaccines; D018167:Receptors, Calcitriol; D047490:Retinoid X Receptor alpha; D014809:Vitamin D-Binding Protein
keywords: HBV vaccination; gene polymorphisms; hemodialysis; vitamin D; vitamin D receptor