title: Irreversible acute renal failure and cholestatic hepatitis following therapy with indomethacin in an HIV-naive patient with pericarditis: a case report.
abstract: The most frequent clinical manifestation of cardiovascular diseases in patients with AIDS is pericarditis. Indomethacin is a well tolerated non-steroidal inflammatory drug (NSAID) widely used in the treatment of pericarditis but it can provoke acute renal failure. Tenofovir has also been associated with chronic renal dysfunction. Liver damage can occur during treatment with NSAIDs. We describe the first case of acute renal failure and cholestatic hepatitis occurring in an HIV-naive patient with pericarditis starting HAART (highly active antiretroviral therapy) and assuming indomethacin and antibiotic therapy for opportunistic infections (OIs) at the same time. Based on our case we suggest that attention be paid to drug-drug interactions in such patients.
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Universita di Palermo, Palermo, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Colomba
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Universita di Palermo, Palermo, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Siracusa
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Universita di Palermo, Palermo, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Madonia
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Universita di Palermo, Palermo, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bonura
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Universita di Palermo, Palermo, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Rubino
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced* / Q000150:complications; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010493:Pericarditis / Q000150:complications*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin