title: 8q24 amplified segments involve novel fusion genes between NSMCE2 and long noncoding RNAs in acute myelogenous leukemia.
abstract: The pathogenetic roles of 8q24 amplified segments in leukemic cells with double minute chromosomes remain to be verified. Through comprehensive molecular analyses of 8q24 amplicons in leukemic cells from an acute myelogenous leukemia (AML) patient and AML-derived cell line HL60 cells, we identified two novel fusion genes between NSMCE2 and long noncoding RNAs (lncRNAs), namely, PVT1-NSMCE2 and BF104016-NSMCE2. Our study suggests that 8q24 amplicons are associated with the emergence of aberrant chimeric genes between NSMCE2 and oncogenic lncRNAs, and also implicate that the chimeric genes involving lncRNAs potentially possess as-yet-unknown oncogenic functional roles.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Chinen
authors.forename: Natsumi
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Hisao
authors.initials: H
authors.lastname: Nagoshi
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Taki
authors.forename: Saori
authors.initials: S
authors.lastname: Maegawa
authors.forename: Shotaro
authors.initials: S
authors.lastname: Tatekawa
authors.forename: Taku
authors.initials: T
authors.lastname: Tsukamoto
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Mizutani
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimura
authors.forename: Mio
authors.initials: M
authors.lastname: Yamamoto-Sugitani
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Horiike
authors.forename: Junya
authors.initials: J
authors.lastname: Kuroda
authors.forename: Masafumi
authors.initials: M
authors.lastname: Taniwaki
mesh_terms: D059786:Abnormal Karyotype; D000368:Aged; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D005784:Gene Amplification; D018922:HL-60 Cells; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008025:Ligases / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C521123:PVT1 long-non-coding RNA, human; D062085:RNA, Long Noncoding; C000613877:long noncoding RNA CCDC26, human; D008025:Ligases; C503501:NSMCE2 protein, human