title: Nociceptive sensitization and BDNF up-regulation in a rat model of traumatic brain injury.
abstract: Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking TBI to pain experienced in the periphery have not been described. In this set of studies we examined nociceptive sensitization and changes in spinal cord gene expression using the rat lateral fluid percussion model of mild TBI. We did not identify changes in thermal nociceptive thresholds in rats with mild TBI. However, mechanical allodynia in hind paws contralateral to TBI was significant and sustained. We also found that spinal cord levels of brain derived neurotrophic factor (BDNF) but not several other pain-related genes were up-regulated one week after injury. Our findings suggest that TBI-induced up-regulation of spinal BDNF levels might contribute to chronic TBI-related pain, and that the lateral fluid percussion model might be useful for exploring this relationship.
authors.affiliation: Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, Stanford, CA 94305, United States.
authors.forename: David P
authors.initials: DP
authors.lastname: Feliciano
authors.affiliation: Anesthesiology Service, VA Palo Alto Healthcare System, 3801 Miranda Avenue, Palo Alto, CA 94304, United States.
authors.forename: Peyman
authors.initials: P
authors.lastname: Sahbaie
authors.affiliation: Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, Stanford, CA 94305, United States; Anesthesiology Service, VA Palo Alto Healthcare System, 3801 Miranda Avenue, Palo Alto, CA 94304, United States.
authors.forename: Xiaoyou
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, Stanford, CA 94305, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Klukinov
authors.affiliation: Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, Stanford, CA 94305, United States; Anesthesiology Service, VA Palo Alto Healthcare System, 3801 Miranda Avenue, Palo Alto, CA 94304, United States. Electronic address: djclark@stanford.edu.
authors.forename: J David
authors.initials: JD
authors.lastname: Clark
authors.affiliation: Department of Anesthesiology Perioperative and Pain Medicine, 291 Campus Drive, Stanford, CA 94305, United States.
authors.forename: David C
authors.initials: DC
authors.lastname: Yeomans
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000378:metabolism* / Q000503:physiopathology* / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D015870:Gene Expression; D008297:Male; D059225:Nociception; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: Brain derived neurotrophic factor; Chronic pain; Traumatic brain injury