title: Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis.
abstract: OBJECTIVE
  To investigate the treatment efficacy of adefovir dipivoxil combined with a corticosteroid on hepatitis B virus-associated glomerulonephritis (HBV-GN).
  
  
  METHODS
  A total of 38 patients with nephrotic syndrome induced by HBV-GN were treated for 36 weeks between 2010 and 2012.
  
  
  RESULTS
  The efficacy analysis showed that 11 patients achieved complete remission and 17 patients achieved partial remission, and the effective remission rate was 73.7%. In addition, 10 patients achieved no remission.
  
  
  CONCLUSIONS
  Adefovir dipivoxil combined with corticosteroids has a certain efficacy on the HBV-GN and displays few adverse reactions. A large sample, randomized double-blind controlled study and long-term follow-up are needed to verify the efficacy of adefovir dipivoxil combined with corticosteroids.
authors.affiliation: Department Nephrology, The Xiangya Hospital of Central South University , Changsha, Hunan , China and.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xinke
authors.initials: X
authors.lastname: Yuan
authors.forename: Linlin
authors.initials: L
authors.lastname: Qiu
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Xiao
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000821:virology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006515:Hepatitis B virus / Q000187:drug effects*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000821:virology; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D063065:Organophosphonates; D000225:Adenine; C106812:adefovir dipivoxil
keywords: Antiviral agents; corticosteroid; efficacy; hepatitis B virus-associated glomerulonephritis; nephrotic syndrome