title: Solvent switchable cycloaddition: a (one-pot) metal-free approach towards N-substituted benzo[e]- or [f]isoindolones via C(sp(2))-H functionalization.
abstract: The tuning of selective ring closure is a nontrivial challenge in synthetic organic chemistry. Herein we report a solvent switchable metal-free [4 + 2] cycloaddition approach via Csp(2)-H functionalization. The protocol is highly atom economical with water being the only by-product, delivering N-substituted benzo[e]- or [f]isoindolones in high yields.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium. erik.vandereycken@chem.kuleuven.be ddvachhani@gmail.com.
authors.forename: Pratik A
authors.initials: PA
authors.lastname: Ambasana
authors.forename: Dipak D
authors.initials: DD
authors.lastname: Vachhani
authors.forename: Marzia
authors.initials: M
authors.lastname: Galli
authors.forename: Jeroen
authors.initials: J
authors.lastname: Jacobs
authors.forename: Luc
authors.initials: L
authors.lastname: Van Meervelt
authors.forename: Anamik K
authors.initials: AK
authors.lastname: Shah
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D012997:Solvents / Q000737:chemistry
chemical_list: C110621:Isoindol-1-one; D054833:Isoindoles; D012997:Solvents