title: Incidence of benign convulsions with mild gastroenteritis after introduction of rotavirus vaccine.
abstract: OBJECTIVE
  Rotavirus was the most common virus in benign convulsions with mild gastroenteritis (CwG), with an incidence of 40-50%. As rotavirus gastroenteritis has decreased since introduction of rotavirus vaccine, we investigated the incidence of CwG and rotavirus positivity after introduction of the vaccine.
  
  
  METHODS
  We retrospectively reviewed the medical records of 987 patients aged between 3months and 3years who were admitted to the Chonnam National University Hospital between March 2005 and February 2014 due to their first seizures and enrolled 102 patients with CwG. The incidences of CwG among seizure patients and stool rotavirus positivity in CwG patients were compared between two periods: period I (March 2005-February 2010) and period II (March 2010-February 2014). Other viruses in stools were also reviewed.
  
  
  RESULTS
  The incidence of CwG were 8.47% (45 among 531 patients) in period I and 12.50% (57 among 456 patients) in period II (P=0.018). Stool rotavirus was checked in 85.29% (87 patients): 82.22% (37 patients) in period I and 87.72% (50 patients) in period II (P=0.166). The positivity of rotavirus was 40.54% (15 patients) in period I and 16.00% (8 patients) in period II (P=0.01). In the patients without rotavirus gastroenteritis, 30 patients were test for other viruses. Norovirus was the most common (56.67%, 17 patients) and was more frequent in period II than I (71.43% versus 22.22%, P=0.018).
  
  
  CONCLUSIONS
  After introduction of rotavirus vaccine, rotavirus-associated CwG has decreased but the incidence of CwG has increased due to an increase of norovirus.
authors.affiliation: Department of Pediatrics, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea. Electronic address: ik052@jnu.ac.kr.
authors.forename: Young Ok
authors.initials: YO
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Han Kyul
authors.initials: HK
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Ho Sung
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Byoung Young
authors.initials: BY
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Kyeong Ryeol
authors.initials: KR
authors.lastname: Cheon
authors.affiliation: Health and Environment Institute of Gwangju, Gwangju, Republic of Korea.
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Health and Environment Institute of Gwangju, Gwangju, Republic of Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Health and Environment Institute of Gwangju, Gwangju, Republic of Korea.
authors.forename: Jae Keun
authors.initials: JK
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, Chonnam National University Medical School, Gwangju, Republic of Korea; Department of Pediatrics, Chonanm National University Hospital, Gwangju, Republic of Korea.
authors.forename: Young Jong
authors.initials: YJ
authors.lastname: Woo
mesh_terms: D002675:Child, Preschool; D005260:Female; D005759:Gastroenteritis / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012400:Rotavirus Infections / Q000150:complications*; D022243:Rotavirus Vaccines; D012640:Seizures / Q000453:epidemiology* / Q000209:etiology*
chemical_list: D022243:Rotavirus Vaccines
keywords: Benign convulsions; Children; Gastroenteritis; Rotavirus; Vaccine