title: The effect of pulsatile cardiopulmonary bypass on lung function in elderly patients.
abstract: OBJECTIVE
  Cardiopulmonary bypass is still a major cause of lung injury and delay in pulmonary recovery after cardiac surgery. Although it has been shown that pulsatile flow induced by intra-aortic balloon pumping is beneficial for preserving lung function, it is not clear if the same beneficial effect can be accomplished with pulsatile flow generated in the extracorporeal circuit. Therefore, we investigated the effect of pulsatile flow, produced by a centrifugal pump, on lung function in elderly patients.
  
  
  METHODS
  Serial measurements of lung biomarkers Clara cell 16 kD protein, surfactant protein D, and elastase were performed on blood samples from 37 elderly patients (≥75 years) who underwent elective aortic valve replacement surgery with CPB, either with pulsatile perfusion or continuous perfusion. Pulmonary function was assessed by postoperative ventilation time, the arterial blood oxygenation (PaO2/FiO2), the alveolar-arterial oxygen gradient (Aa-O2 gradient) and the pulmonary vascular resistance indexed by body surface area (PVRi).
  
  
  RESULTS
  There was no difference in lung function between both groups, as assessed by the postoperative ventilation time, the PaO2/FiO2 ratio, and the Aa-O2 gradient. The PVRi, however, was significantly lower in the pulsatile perfusion group 15 mins after the administration of protamine (p<0.05). The plasma concentrations of the lung biomarkers increased during surgery and peaked at 1 h ICU, there were however no differences between groups.
  
  
  CONCLUSIONS
  Pulsatile flow does not seem beneficial to postoperative lung function in elderly patients. Moreover, pulsatile flow does not affect lung function on a subclinical level as assessed by lung biomarkers.
authors.affiliation: 1 HaemoScan BV, Groningen - The Netherlands.
authors.forename: Gerwin E
authors.initials: GE
authors.lastname: Engels
authors.forename: Mikhail
authors.initials: M
authors.lastname: Dodonov
authors.forename: Gerhard
authors.initials: G
authors.lastname: Rakhorst
authors.forename: Willem
authors.initials: W
authors.lastname: van Oeveren
authors.forename: Aldo D
authors.initials: AD
authors.lastname: Milano
authors.forename: Y John
authors.initials: YJ
authors.lastname: Gu
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Faggian
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods*; D017558:Elective Surgical Procedures; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007558:Italy; D019272:Leukocyte Elastase / Q000097:blood; D008168:Lung / Q000378:metabolism / Q000503:physiopathology*; D055370:Lung Injury / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood; D011673:Pulsatile Flow; D013997:Time Factors; D016896:Treatment Outcome; D014598:Uteroglobin / Q000097:blood
chemical_list: D015415:Biomarkers; D037663:Pulmonary Surfactant-Associated Protein D; D014598:Uteroglobin; D019272:Leukocyte Elastase