title: The role of microRNAs in diabetic nephropathy.
abstract: Diabetic nephropathy (DN), as one of the chronic complications of diabetes, is the major cause of end-stage renal disease. However, the pathogenesis of this disease is not fully understood. In recent years, research on microRNAs (miRNAs) has become a hotspot because of their critical role in regulating posttranscriptional levels of protein-coding genes that may serve as key pathogenic factors in diseases. Several miRNAs were found to participate in the pathogenesis of DN, while others showed renal protective effects. Therefore, targeting miRNAs that are involved in DN may have a good prospect in the treatment of the disease. The aim of this review is to summarize DN-related miRNAs and provide potential targets for diagnostic strategies and therapeutic intervention.
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China ; Chinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Hao
authors.identifier: 0000-0001-5738-4015
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Kong
authors.affiliation: Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA ; Cardiovascular Center, The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Shanshan
authors.identifier: 0000-0003-1689-0266
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Cui
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Feng
authors.identifier: 0000-0002-1538-2908
authors.initials: F
authors.lastname: Xu
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Manyu
authors.identifier: 0000-0002-3081-2793
authors.initials: M
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Shanghai 200031, China.
authors.forename: Xiangqi
authors.initials: X
authors.lastname: Li
authors.affiliation: Chinese-American Research Institute for Diabetic Complications at Wenzhou Medical University, Wenzhou 325035, China ; Kosair Children's Hospital Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.
authors.forename: Lining
authors.initials: L
authors.lastname: Miao
mesh_terms: D000107:Acetylation; D000818:Animals; D002843:Chromatin / Q000737:chemistry; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D018450:Disease Progression; D004285:Dogs; D044127:Epigenesis, Genetic; D057890:Epigenomics; D006657:Histones / Q000737:chemistry; D006801:Humans; D007249:Inflammation; D007668:Kidney / Q000473:pathology; D008239:Lysine / Q000737:chemistry; D008745:Methylation; D051379:Mice; D008822:Mice, Transgenic; D035683:MicroRNAs / Q000378:metabolism*; D051381:Rats
chemical_list: D002843:Chromatin; D006657:Histones; D035683:MicroRNAs; D008239:Lysine