title: Insulin therapy in cardiac surgery.
abstract: Aside from its actions on glycaemic control, insulin has been demonstrated to have a wide range of effects on the cardiovascular system. During the peri-operative period, the stress response to surgery leads to hyperglycaemia. There is continuing debate with regard to the level of glycaemic control and the potential benefits of insulin therapy in both diabetic and non-diabetic patients undergoing cardiac surgery. This review article sets out to discuss the evidence for glycaemic control, as well as the potential benefits of insulin therapy in the form of glucose-insulin-potassium therapy in cardiac surgery.
authors.forename: Ashvini
authors.initials: A
authors.lastname: Menon
authors.affiliation: Consultant Cardiothoracic Surgeon, UHB NHS FT, Department of Cardiac Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, UK. aaron.ranasinghe@uhb.nhs.uk.
authors.forename: A M
authors.initials: AM
authors.lastname: Ranasinghe
mesh_terms: D001786:Blood Glucose / Q000378:metabolism; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D016638:Critical Illness; D019317:Evidence-Based Medicine; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D007431:Intraoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism; D019990:Perioperative Care; D011183:Postoperative Complications / Q000378:metabolism / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin