title: Successful treatment of genital Bowen's disease with imiquimod 5% cream.
abstract: A 64-year-old Japanese woman was diagnosed as having Bowen's disease on the vulva. The histopathological findings revealed papillomatosis, koilocytosis and clumping cells with atypical nuclei. Human papillomavirus DNA was not detected on polymerase chain reaction using consensus primers. The lesion was successfully treated with topical imiquimod 5% cream after two months. Histopathologically, no atypical cells were observed after treatment. Imiquimod can be a potential treatment modality for lesions that are difficult to treat with surgical excision.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors.forename: Chikako
authors.initials: C
authors.lastname: Kishi
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, Japan shimizuakira@gunma-u.ac.jp.
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors.forename: Madoka
authors.initials: M
authors.lastname: Kato
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors.forename: Hiroo
authors.initials: H
authors.lastname: Amano
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Gunma University, Maebashi, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D000077271:Imiquimod; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: Bowen’s disease in the vulva; HPV; VIN; human papillomavirus; imiquimod; treatment; vulvar intraepithelial neoplasia