title: Relationship between CCR and NT-proBNP in Chinese HF patients, and their correlations with severity of HF.
abstract: OBJECTIVE
  To evaluate the relationship between creatinine clearance rate (CCR) and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in heart failure (HF) patients and their correlations with HF severity.
  
  
  RESULTS
  Two hundred and one Chinese patients were grouped according to the New York Heart Association (NYHA) classification as NYHA 1-2 and 3-4 groups and 135 cases out of heart failure patients as control group. The following variables were compared among these three groups: age, sex, body mass index (BMI), smoking status, hypertension, diabetes, NT-proBNP, creatinine (Cr), uric acid (UA), left ventricular end-diastolic diameter (LVEDD), and CCR. The biomarkers of NT-proBNP, Cr, UA, LVEDD, and CCR varied significantly in the three groups, and these variables were positively correlated with the NHYA classification. The levels of NT-proBNP and CCR were closely related to the occurrence of HF and were independent risk factors for HF. At the same time, there was a significant negative correlation between the levels of NT-proBNP and CCR. The area under the receiver operating characteristic curve suggested that the NT-proBNP and CCR have high accuracy for diagnosis of HF and have clinical diagnostic value.
  
  
  CONCLUSIONS
  NT-proBNP and CCR may be important biomarkers in evaluating the severity of HF.
authors.affiliation: Department of Cardiology, The 6th People's Hospital Affiliated to Shanghai Jiaotong University Medical College, No. 600 Yishan Road, Shanghai, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Clinical Laboratory, Dalian Municipal Central Hospital, Dalian, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Neurology, The 148th Hospital, Zibo, Shandong, China.
authors.forename: Yunliang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Medlogic Healthcare Technology Company Ltd., Shanghai, China.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Qian
authors.affiliation: Laboratory of Medicine, General Hospital of Shenyang Military Area Command, Shenyang, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Cardiology, The 6th People's Hospital Affiliated to Shanghai Jiaotong University Medical College, No. 600 Yishan Road, Shanghai, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wei
mesh_terms: D017677:Age Distribution; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002681:China / Q000453:epidemiology; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D003404:Creatinine