title: Positive relationship between total antioxidant status and chemokines observed in adults.
abstract: OBJECTIVE
  Human evidence is limited regarding the interaction between oxidative stress biomarkers and chemokines, especially in a population of adults without overt clinical disease. The current study aims to examine the possible relationships of antioxidant and lipid peroxidation markers with several chemokines in adults.
  
  
  METHODS
  We assessed cross-sectional associations of total antioxidant status (TAS) and two lipid peroxidation markers malondialdehyde (MDA) and thiobarbituric acid reactive substances (TBARS) with a suite of serum chemokines, including CXCL-1 (GRO-α), CXCL-8 (IL-8), CXCL-10 (IP-10), CCL-2 (MCP-1), CCL-5 (RANTES), CCL-8 (MCP-2), CCL-11 (Eotaxin-1), and CCL-17 (TARC), among 104 Chinese adults without serious preexisting clinical conditions in Beijing before 2008 Olympics.
  
  
  RESULTS
  TAS showed significantly positive correlations with MCP-1 (r = 0.15751, P = 0.0014), MCP-2 (r = 0.3721, P = 0.0001), Eotaxin-1 (r = 0.39598, P < 0.0001), and TARC (r = 0.27149, P = 0.0053). The positive correlations remained unchanged after controlling for age, sex, body mass index, smoking, and alcohol drinking status. No associations were found between any of the chemokines measured in this study and MDA or TBARS. Similar patterns were observed when the analyses were limited to nonsmokers.
  
  
  CONCLUSIONS
  Total antioxidant status is positively associated with several chemokines in this adult population.
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Yanli
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Biotechnical and Clinical Laboratory Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Richard W
authors.initials: RW
authors.lastname: Browne
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Bonner
authors.affiliation: Department of Environmental Health, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Furong
authors.initials: F
authors.lastname: Deng
authors.affiliation: Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Tian
authors.affiliation: Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214, USA.
authors.forename: Lina
authors.initials: L
authors.lastname: Mu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D018925:Chemokines; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde; D002097:C-Reactive Protein