title: Poly-guanidinoethylphenylethers organised around a benzene ring: synthesis and evaluation of their antibacterial and cytotoxic properties.
abstract: A new family of poly-guanidinium species with a benzene core as the organising agent has been developed. Their antibacterial properties have been evaluated against reference Gram positive and Gram negative bacteria, and their cytotoxicity against eukaryotic cells. Most of these compounds exhibited Minimum Inhibitory Concentrations in the micromolar range.
authors.affiliation: CNRS, SRSMC, UMR 7565, Vandœuvre-lès-Nancy, F-54506, France; Université de Lorraine, SRSMC, UMR 7565, Nancy F-54001, France.
authors.forename: Hugues
authors.initials: H
authors.lastname: Massimba Dibama
authors.affiliation: CNRS, SRSMC, UMR 7565, Vandœuvre-lès-Nancy, F-54506, France; Université de Lorraine, SRSMC, UMR 7565, Nancy F-54001, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Mourer
authors.affiliation: CNRS, SRSMC, UMR 7565, Vandœuvre-lès-Nancy, F-54506, France; Université de Lorraine, SRSMC, UMR 7565, Nancy F-54001, France; ABC Platform®, Nancy F-54001, France.
authors.forename: Raphaël E
authors.initials: RE
authors.lastname: Duval
authors.affiliation: CNRS, SRSMC, UMR 7565, Vandœuvre-lès-Nancy, F-54506, France; Université de Lorraine, SRSMC, UMR 7565, Nancy F-54001, France. Electronic address: jean-bernard.regnouf@univ-lorraine.fr.
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Regnouf-de-Vains
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019791:Guanidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D001555:Benzene Derivatives; D003603:Cytotoxins; D010647:Phenyl Ethers; D019791:Guanidine
keywords: Ammonium; Antibacterial; Benzene; Cytotoxicity; Guanidinium