title: ["En face" anterior segment optical coherence tomography findings in acute corneal hydrops].
abstract: OBJECTIVE
  To study the corneal morphological characteristics of acute hydrops by analyzing anterior segment optical coherence tomography (AS-OCT) "en face" images.
  
  
  METHODS
  Four patients presenting with acute hydrops were examined at different stages, respectively after 1 day, 1 week, 3 weeks and 6 months. All patients had a complete ophthalmic evaluation including "en face" AS-OCT examination. In vivo confocal microscopy (IVCM) and histological analysis of the cornea obtained after penetrating keratoplasty were also performed in one patient.
  
  
  RESULTS
  The "en face" AS-OCT showed that the early edema in acute hydrops corresponded to multiple epithelial microcysts associated with large intra-stromal lacunae. We also observed that, in association with the disappearance of the microcysts and lacunae, "en face" OCT demonstrated subepithelial scars in the form of weakly reflective, fine, interlaced linear opacities. These opacities subsequently increased in thickness resulting in a dense subepithelial network. These findings were consistent with the results of histological and IVCM studies.
  
  
  CONCLUSIONS
  "En face" AS-OCT allows for precise study of the tissue changes occurring in acute corneal hydrops. Besides a better understanding of this rare complication of keratoconus, this new imaging technique may help clinicians to identify the corneal structural changes, which place keratoconus patients at risk of corneal hydrops.
authors.affiliation: Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Centre d'investigation clinique, CIC Inserm 503, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. Electronic address: sofien_kallel@yahoo.fr.
authors.forename: S
authors.initials: S
authors.lastname: Kallel
authors.affiliation: Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Centre d'investigation clinique, CIC Inserm 503, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Tahiri Joutei Hassani
authors.affiliation: Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Centre d'investigation clinique, CIC Inserm 503, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Inserm, U968, 75012 Paris, France; Institut de la Vision, université UPMC Paris 06, UMR-S 968, 75012 Paris, France; CNRS, UMR 7210, 75012 Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Liang
authors.affiliation: Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Centre d'investigation clinique, CIC Inserm 503, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Inserm, U968, 75012 Paris, France; Institut de la Vision, université UPMC Paris 06, UMR-S 968, 75012 Paris, France; CNRS, UMR 7210, 75012 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Baudouin
authors.affiliation: Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, université de Versailles Saint-Quentin-en-Yvelines, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Centre d'investigation clinique, CIC Inserm 503, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Inserm, U968, 75012 Paris, France; Institut de la Vision, université UPMC Paris 06, UMR-S 968, 75012 Paris, France; CNRS, UMR 7210, 75012 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Labbé
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002921:Cicatrix / Q000175:diagnosis / Q000473:pathology; D015715:Corneal Edema / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003318:Corneal Opacity / Q000175:diagnosis / Q000473:pathology; D003319:Corneal Stroma / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D015948:Keratoplasty, Penetrating; D008297:Male; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult
keywords: Acute hydrops; Hydrops cornéen; In vivo confocal microscopy; Microscopie confocale in vivo; OCT de segment antérieur en face; “En face” AS-OCT