title: In vitro interaction of colloidal nanoparticles with mammalian cells: What have we learned thus far?
abstract: The interfacing of colloidal nanoparticles with mammalian cells is now well into its second decade. In this review our goal is to highlight the more generally accepted concepts that we have gleaned from nearly twenty years of research. While details of these complex interactions strongly depend, amongst others, upon the specific properties of the nanoparticles used, the cell type, and their environmental conditions, a number of fundamental principles exist, which are outlined in this review.
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Moritz
authors.initials: M
authors.lastname: Nazarenus
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Mahmoud G
authors.initials: MG
authors.lastname: Soliman
authors.affiliation: CIC Biomagune, Paseo Miramón 182, 20009 San Sebastian, Spain.
authors.forename: Pablo
authors.initials: P
authors.lastname: Del Pino
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Pelaz
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Susana
authors.initials: S
authors.lastname: Carregal-Romero
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany.
authors.forename: Joanna
authors.initials: J
authors.lastname: Rejman
authors.affiliation: BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Route de L'ancienne Papeterie CP 209, Marly 1, 1723, Fribourg, Switzerland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Rothen-Rutishauser
authors.affiliation: BioNanomaterials, Adolphe Merkle Institute, University of Fribourg, Route de L'ancienne Papeterie CP 209, Marly 1, 1723, Fribourg, Switzerland.
authors.forename: Martin J D
authors.initials: MJ
authors.lastname: Clift
authors.affiliation: Institute of Physical Chemistry, University of Duisburg-Essen, Universitätsstraße 5, 45141 Essen, Germany.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Zellner
authors.affiliation: Institute of Applied Physics and Institute of Toxicology and Genetics, Karlsruhe Institute of Technology (KIT), Wolfgang-Gaede-Straße 1, 76131 Karlsruhe, Germany ; Department of Physics, University of Illinois at Urbana-Champaign, 1110 West Green Street, Urbana, IL 61801, USA.
authors.forename: G Ulrich
authors.initials: GU
authors.lastname: Nienhaus
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, 4555 Overlook Avenue Southwest, Washington D.C., 20375, USA.
authors.forename: James B
authors.initials: JB
authors.lastname: Delehanty
authors.affiliation: Center for Bio/Molecular Science & Engineering, Code 6900, U.S. Naval Research Laboratory, 4555 Overlook Avenue Southwest, Washington D.C., 20375, USA.
authors.forename: Igor L
authors.initials: IL
authors.lastname: Medintz
authors.affiliation: Fachbereich Physik, Philipps-Universität Marburg, Renthof 7, 35037 Marburg, Germany ; CIC Biomagune, Paseo Miramón 182, 20009 San Sebastian, Spain.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
keywords: colloidal stability; intracellular particle distribution; nanoparticles; protein corona; toxicity of nanoparticles