title: Association between prenatal exposure to metals and neonatal morbidity.
abstract: An association between prenatal exposure to (semi-)metals and of neonatal morbidity was assessed by introducing an oxidative stress as a possible intermediate step. An oxidative stress was measured by cell proliferation (CP) ratio in umbilical cord blood cells. Urine samples of 18 out of 58 enrolled women (31%) were positive for (semi-)metals; 25.9% of women were positive for aluminum (Al). The CP ratio was higher (1) in subjects with Al, (2) in mothers to newborns diagnosed as small-for-gestational age (p value = .052), (3) neonates that weighed less (p value = .079), and (4) in women who experienced repeated abortions (p value = .049). Our findings suggest the possibility of metal-induced oxidative stress.
authors.affiliation: a Department of Environmental Epidemiology , Public Health Services, Ministry of Health , Jerusalem , Israel.
authors.forename: Isabella
authors.initials: I
authors.lastname: Karakis
authors.forename: Batia
authors.initials: B
authors.lastname: Sarov
authors.forename: Daniella
authors.initials: D
authors.lastname: Landau
authors.forename: Esther
authors.initials: E
authors.lastname: Manor
authors.forename: Maayan
authors.initials: M
authors.lastname: Yitshak-Sade
authors.forename: Michal
authors.initials: M
authors.lastname: Rotenberg
authors.forename: Reli
authors.initials: R
authors.lastname: Hershkovitz
authors.forename: Itamar
authors.initials: I
authors.lastname: Grotto
authors.forename: Elena
authors.initials: E
authors.lastname: Gurevich
authors.forename: Lena
authors.initials: L
authors.lastname: Novack
mesh_terms: D000328:Adult; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D005312:Fetal Blood / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005865:Gestational Age; D006801:Humans; D057230:Limit of Detection; D018811:Maternal Exposure / Q000009:adverse effects*; D008670:Metals / Q000008:administration & dosage / Q000633:toxicity* / Q000652:urine; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D008670:Metals