title: [Recent progress in interferon induced protein GBP1 research].
abstract: Guanylate-binding protein 1 (GBP1) is an interferon induced protein, that belongs to the guany late-binding protein family. GBP1 is widely involved in anti-infection immune responses, anti-tumor activity and various biological reactions. Recent studies have proved that IFN-alpha, IFN-beta, IFN-gamma, IL1alpha, IL1beta, TNF-alpha and LPS can induce GBP1 expression; hence, the diverse biological functions of GBP1 have been gradually deduced and exploited. Many studies have been performed over recent years to understand the exact mechanisms that underlie the anti-infection and anti-tumor properties of GBP1. This review describes the molecular structure, biological activity, anti-infective properties and other functions of GBP1, in order to provide insights into the divergent roles of GBP1 in the regulation of various biological processes.
authors.forename: Zi-Xiang
authors.initials: ZX
authors.lastname: Zhu
authors.forename: Yang-Chun
authors.initials: YC
authors.lastname: Cao
authors.forename: Wei-Jun
authors.initials: WJ
authors.lastname: Cao
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Ma
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Zheng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism; D000998:Antiviral Agents / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007372:Interferons; D019204:GTP-Binding Proteins