title: Synthesis, characterization and in vitro evaluation of new composite bisphosphonate delivery systems.
abstract: In this study, new composite bisphosphonate delivery systems were obtained from polyurethanes (PUs) and nanocrystalline hydroxyapatite (HA). The biodegradable PUs were first synthesized from poly(ε-caprolactone) diols (PCL diols), poly(ethylene adipate) diol, 1,6-hexamethylene diisocyanate, 1,4-butanediol and HA. Moreover, the PCL diols were synthesized by the ring-opening polymerization catalysed by the lipase from Candida antarctica. Next, composite drug delivery systems for clodronate were prepared. The mechanical properties of the obtained biomaterials were determined. The cytotoxicity of the synthesized polymers was tested. The preliminary results show that the obtained composites are perspective biomaterials and they can be potentially applied in the technology of implantation drug delivery systems.
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. joanna.kolmas@wp.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Kolmas
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. marcin.sobczak@wp.pl.
authors.forename: Marcin
authors.initials: M
authors.lastname: Sobczak
authors.affiliation: Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. eoledzka@wp.pl.
authors.forename: Ewa
authors.initials: E
authors.lastname: Olędzka
authors.affiliation: Department of Environmental Health Science, Faculty of Pharmacy, Medical University of Warsaw, ul. Banacha 1, 02-097 Warsaw, Poland. gnalecz@wum.edu.pl.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Nałęcz-Jawecki
authors.affiliation: Institute for Engineering of Polymer Materials and Dies, ul. Marii Skłodowskiej-Curie 55, 87-100 Toruń, Poland. c.debek@ipgum.pl.
authors.forename: Cezary
authors.initials: C
authors.lastname: Dębek
mesh_terms: D020341:Absorbable Implants; D048908:Aliivibrio fischeri / Q000187:drug effects; D001672:Biocompatible Materials; D016798:Ciliophora / Q000187:drug effects; D004002:Clodronic Acid / Q000008:administration & dosage; D004164:Diphosphonates / Q000008:administration & dosage*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000633:toxicity; D004343:Drug Implants; D017886:Durapatite / Q000633:toxicity; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011140:Polyurethanes / Q000138:chemical synthesis / Q000633:toxicity; D016062:Porosity; D016808:Tetrahymena thermophila / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D004164:Diphosphonates; D004337:Drug Carriers; D004343:Drug Implants; D011140:Polyurethanes; D004002:Clodronic Acid; D017886:Durapatite