title: Anticancer and antimicrobial activities and chemical composition of the birch mazegill mushroom Lenzites betulina (higher Basidiomycetes).
abstract: The anticancer properties, antibiotic activity, and chemical composition of Lenzites betulina ethanol extract (EE) were evaluated. Eight compounds including 5 sterols were isolated from L. betulina, and 7 compounds were isolated from L. betulina for the first time. The EE displayed strong anticancer activity against tumor cell line MDA-MB-231, with a half maximal inhibitory concentration of 51.46 μg/mL, and there was 83.15% inhibition at a concentration of 200 μg/mL (MTT assay). The antimicrobial activity of the EE was evaluated against 6 microorganisms-Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Fusarium graminearum, Gibberella zeae, and Cercosporella albo-maculans-and the EE showed moderate antibiotic activity. These results suggest that L. betulina could be a good anticancer and antibiotic agent.
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China; College of Biology Science and Engineering, Hebei University of Economics and Business, Shijiazhuang, Hebei, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China.
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Wang
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China.
authors.forename: Le
authors.initials: L
authors.lastname: Zhao
authors.affiliation: College of Life and Environmental Sciences, Minzu University of China, Beijing, People's Republic of China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D029662:Betula / Q000382:microbiology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D055453:Coriolaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D050296:Microbial Viability / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents