title: DNA bioassay-on-chip using SERS detection for dengue diagnosis.
abstract: A novel DNA bioassay-on-chip using surface-enhanced Raman scattering (SERS) on a bimetallic nanowave chip is presented. In this bioassay, SERS signals were measured after a single reaction on the chip's surface without any washing step, making it simple-to-use and reducing the reagent cost. Using the technique, specific oligonucleotide sequences of the dengue virus 4 were detected.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. tuan.vodinh@duke.edu.
authors.forename: Hoan T
authors.initials: HT
authors.lastname: Ngo
authors.forename: Hsin-Neng
authors.initials: HN
authors.lastname: Wang
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Fales
authors.forename: Bradly P
authors.initials: BP
authors.lastname: Nicholson
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Woods
authors.forename: Tuan
authors.initials: T
authors.lastname: Vo-Dinh
mesh_terms: D001681:Biological Assay; D004279:DNA, Viral / Q000032:analysis*; D003715:Dengue / Q000175:diagnosis*; D003716:Dengue Virus / Q000235:genetics*; D006801:Humans; D056656:Lab-On-A-Chip Devices; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning
chemical_list: D004279:DNA, Viral