title: Sex-determination gene SRY potentially associates with poor prognosis but not sex bias in hepatocellular carcinoma.
abstract: BACKGROUND
  Gender disparity is well known in hepatocellular carcinoma (HCC). SRY is a critical sex-determination gene involved in embryonic development.
  
  
  OBJECTIVE
  The potential relevance of SRY to HCC progression was evaluated.
  
  
  METHODS
  SRY expression in HCC cell lines and tissues was evaluated. Invasion and wound healing assays were used to evaluate the role of SRY in HCC cell migration. The prognostic value of SRY for HCC patient survival was evaluated.
  
  
  RESULTS
  SRY was highly expressed in HCC cell lines and tumor tissues. Downregulation of SRY expression decreased migration and invasion potential of HCC cells. High SRY levels correlated with poor HCC patient survival. Additionally, neither spatial position nor expression intensity of SRY was correlated with HCC gender disparity.
  
  
  CONCLUSIONS
  High levels of SRY expression correlated with cancer progression and poor HCC patient survival. However, high SRY levels are not significantly correlated with HCC sex bias.
authors.affiliation: Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China, xue.tongchun@zs-hospital.sh.cn.
authors.forename: Tong-Chun
authors.initials: TC
authors.lastname: Xue
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Ren
authors.forename: Rong-Xin
authors.initials: RX
authors.lastname: Chen
authors.forename: Jie-Feng
authors.initials: JF
authors.lastname: Cui
authors.forename: Ning-Ling
authors.initials: NL
authors.lastname: Ge
authors.forename: Sheng-Long
authors.initials: SL
authors.lastname: Ye
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D015153:Blotting, Western; D051927:CD24 Antigen / Q000235:genetics / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D002465:Cell Movement; D018572:Disease-Free Survival; D005260:Female; D056945:Hep G2 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D008297:Male; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D055758:SOX9 Transcription Factor / Q000235:genetics / Q000378:metabolism; D012737:Sex Factors; D051876:Sex-Determining Region Y Protein / Q000235:genetics / Q000378:metabolism*; D013997:Time Factors; D046888:Tissue Array Analysis; D014162:Transfection; D015854:Up-Regulation; D014945:Wound Healing
chemical_list: D014408:Biomarkers, Tumor; D051927:CD24 Antigen; C497889:CD24 protein, human; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein