title: T-wave reversion in pediatric patients during exercise stress testing.
abstract: OBJECTIVE
  T-wave inversion in lateral electrocardiogram (ECG) leads (II, III, aVF, V4 -V6 ) is suspicious of cardiac pathology in pediatric patients, though many are found to have structurally normal hearts. The purpose of this study is to evaluate T-wave response during exercise stress testing (EST) in pediatric patients with structurally normal hearts and lateral-lead T-wave inversion on resting ECG.
  
  
  METHODS
  An IRB-approved, retrospective review of EST databases at two centers identified patients with lateral-lead T-wave inversion on resting ECG. Inclusion criteria were normal exam and echocardiogram, absence of anginal chest pain, and age <18 years. All patients underwent treadmill or cycle ergometer EST. Data recorded included demographics, echocardiogram results, baseline ECG, EST method, peak heart rate and metabolic equivalents (METs), and heart rate and METs at T-wave reversion. T-wave reversion was considered complete if T-waves reverted in all leads, partial if reversion occurred in only some leads, and none if no reversion occurred.
  
  
  RESULTS
  The search identified 14 patients: nine females and five males (10 Caucasians and four African Americans) and an average age of 16 (range 12-18) years. Complete T-wave reversion occurred in 11 (79%) patients, partial in two (14%), and none in one (7%). Reversion occurred in both genders, ethnicities, and EST methods. No complications occurred during EST; no adverse outcomes occurred during 2-year follow-up.
  
  
  CONCLUSIONS
  EST in pediatric patients with lateral-lead T-wave inversion on resting ECG and structurally and functionally normal hearts resulted in either complete or partial T-wave reversion in the vast majority of patients.
authors.affiliation: Department of Pediatrics, Division of Pediatric Cardiology, University of Virginia, Charlottesville, Va, USA.
authors.forename: Walter J
authors.initials: WJ
authors.lastname: Hoyt
authors.forename: Kipp B
authors.initials: KB
authors.lastname: Ardoin
authors.forename: Bryan C
authors.initials: BC
authors.lastname: Cannon
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Snyder
mesh_terms: D000293:Adolescent; D002648:Child; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D012189:Retrospective Studies
keywords: ECG Abnormality; Exercise Stress Test; T-wave Inversion