title: Granzyme h serum levels variations with both reproductive hormone receptors, and related hormone receptors in breast cancer patients.
abstract: BACKGROUND
  Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.
  
  
  METHODS
  30 breast cancer patients, and 30 control women in premenopausal status, have participated in this study. GZMH, Estrogen levels, and ER, PR have been measured in cancer and healthy women subsequently, as using ELISA, Radioimmunoassay, and Immunohistochemistry methods.
  
  
  RESULTS
  Mean GZMH value was lower in BC than healthy women (p<0.0001).
  
  
  CONCLUSIONS
  Our study has implicated existence of suppressor or problem for producing of GZMH in patients group and levels of estrogen couldn't effect on making positive ER, PR.
authors.affiliation: Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Behnoosh
authors.initials: B
authors.lastname: Tahbaz-Lahafi
authors.affiliation: Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Esmaeil
authors.initials: ME
authors.lastname: Akbari
authors.affiliation: Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Houshang
authors.initials: H
authors.lastname: Amir-Rassouli
authors.affiliation: Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rahimipour
authors.affiliation: Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Eznollah
authors.initials: E
authors.lastname: Azargashb
authors.affiliation: Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Nahid
authors.initials: N
authors.lastname: Nafissi
authors.affiliation: Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Farida
authors.initials: F
authors.lastname: Jahani
keywords: Breast Cancer; Estrogen; Granzyme H