title: A tripartite cocktail of chimeric monoclonal antibodies passively protects mice against ricin, staphylococcal enterotoxin B and Clostridium perfringens epsilon toxin.
abstract: Due to the fast-acting nature of ricin, staphylococcal enterotoxin B (SEB), and Clostridium perfringens epsilon toxin (ETX), it is necessary that therapeutic interventions following a bioterrorism incident by one of these toxins occur as soon as possible after intoxication. Moreover, because the clinical manifestations of intoxication by these agents are likely to be indistinguishable from each other, especially following aerosol exposure, we have developed a cocktail of chimeric monoclonal antibodies that is capable of neutralizing all three toxins. The efficacy of this cocktail was demonstrated in mouse models of lethal dose toxin challenge.
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Erin K
authors.initials: EK
authors.lastname: Sully
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Kevin
authors.initials: K
authors.lastname: Whaley
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Bohorova
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Ognian
authors.initials: O
authors.lastname: Bohorov
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Goodman
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Do
authors.initials: D
authors.lastname: Kim
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Pauly
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA.
authors.forename: Jesus
authors.initials: J
authors.lastname: Velasco
authors.affiliation: Integrated BioTherapeutics, Gaithersburg, MD, USA.
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Holtsberg
authors.affiliation: Integrated BioTherapeutics, Gaithersburg, MD, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Stavale
authors.affiliation: Integrated BioTherapeutics, Gaithersburg, MD, USA.
authors.forename: M Javad
authors.initials: MJ
authors.lastname: Aman
authors.affiliation: Department of Veterinary Sciences, Iowa State University, USA.
authors.forename: Chandra
authors.initials: C
authors.lastname: Tangudu
authors.affiliation: University of California, Davis, USA.
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Uzal
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY, USA; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, NY, USA. Electronic address: nicholas.mantis@health.ny.gov.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Mantis
authors.affiliation: Mapp Biopharmaceutical, Inc., 92121 San Diego, CA, USA. Electronic address: larry.zeitlin@mappbio.com.
authors.forename: Larry
authors.initials: L
authors.lastname: Zeitlin
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000633:toxicity*; D023482:Bioterrorism / Q000517:prevention & control*; D004768:Enterotoxins / Q000633:toxicity*; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D009500:Neutralization Tests; D011041:Poisoning / Q000517:prevention & control*; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D012276:Ricin / Q000633:toxicity*
chemical_list: D000911:Antibodies, Monoclonal; D001427:Bacterial Toxins; C039811:Clostridium perfringens epsilon-toxin; D004768:Enterotoxins; D011993:Recombinant Fusion Proteins; C031818:enterotoxin B, staphylococcal; D012276:Ricin
keywords: Antibody; Biodefense; Therapeutic; Toxin