title: Syntheses, spectroscopic characterization, thermal study, molecular modeling, and biological evaluation of novel Schiff's base benzil bis(5-amino-1,3,4-thiadiazole-2-thiol) with Ni(II), and Cu(II) metal complexes.
abstract: Novel Schiff's base ligand, benzil bis(5-amino-1,3,4-thiadiazole-2-thiol) was synthesized by the condensation of benzil and 5-amino-1,3,4-thiadiazole-2-thiol in 1:2 ratio. The structure of ligand was determined on the basis of elemental analyses, IR, (1)H NMR, mass, and molecular modeling studies. Synthesized ligand behaved as tetradentate and coordinated to metal ion through sulfur atoms of thiol ring and nitrogen atoms of imine group. Ni(II), and Cu(II) complexes were synthesized with this nitrogen-sulfur donor (N2S2) ligand. Metal complexes were characterized by elemental analyses, molar conductance, magnetic susceptibility measurements, IR, electronic spectra, EPR, thermal, and molecular modeling studies. All the complexes showed molar conductance corresponding to non-electrolytic nature, expect [Ni(L)](NO3)2 complex, which was 1:2 electrolyte in nature. [Cu(L)(SO4)] complex may possessed square pyramidal geometry, [Ni(L)](NO3)2 complex tetrahedral and rest of the complexes six coordinated octahedral/tetragonal geometry. Newly synthesized ligand and its metal complexes were examined against the opportunistic pathogens. Results suggested that metal complexes were more biological sensitive than free ligand.
authors.affiliation: Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN Marg, New Delhi 110002, India. Electronic address: schandra_00@yahoo.com.
authors.forename: Sulekh
authors.initials: S
authors.lastname: Chandra
authors.affiliation: Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN Marg, New Delhi 110002, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Gautam
authors.affiliation: Department of Chemistry, Ramjas College, University of Delhi, New Delhi 110007, India.
authors.forename: Hament Kumar
authors.initials: HK
authors.lastname: Rajor
authors.affiliation: University of Delhi, New Delhi 110007, India.
authors.forename: Rohit
authors.initials: R
authors.lastname: Bhatia
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry; D001234:Aspergillus niger / Q000378:metabolism; D003300:Copper / Q000737:chemistry*; D004058:Diffusion; D004926:Escherichia coli / Q000378:metabolism; D005658:Fungi / Q000378:metabolism; D005670:Fusarium / Q000378:metabolism; D006358:Hot Temperature; D007711:Klebsiella pneumoniae / Q000378:metabolism; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000378:metabolism; D012232:Rhizoctonia / Q000378:metabolism; D012545:Schiff Bases / Q000737:chemistry*; D013053:Spectrophotometry; D013211:Staphylococcus aureus / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D008024:Ligands; D008670:Metals; D012545:Schiff Bases; D013438:Sulfhydryl Compounds; D003300:Copper; D009532:Nickel
keywords: Biological evaluation; Metal complexes; Molecular modeling; Schiff’s bases; Spectral studies