title: Both central and peripheral auditory systems are involved in salicylate-induced tinnitus in rats: a behavioral study.
abstract: OBJECTIVE
  This study was designed to establish a low dose salicylate-induced tinnitus rat model and to investigate whether central or peripheral auditory system is involved in tinnitus.
  
  
  METHODS
  Lick suppression ratio (R), lick count and lick latency of conditioned rats in salicylate group (120 mg/kg, intraperitoneally) and saline group were first compared. Bilateral auditory nerves were ablated in unconditioned rats and lick count and lick latency were compared before and after ablation. The ablation was then performed in conditioned rats and lick count and lick latency were compared between salicylate group and saline group and between ablated and unablated salicylate groups.
  
  
  RESULTS
  Both the R value and the lick count in salicylate group were significantly higher than those in saline group and lick latency in salicylate group was significantly shorter than that in saline group. No significant changes were observed in lick count and lick latency before and after ablation. After ablation, lick count and lick latency in salicylate group were significantly higher and shorter respectively than those in saline group, but they were significantly lower and longer respectively than those in unablated salicylate group.
  
  
  CONCLUSIONS
  A low dose of salicylate (120 mg/kg) can induce tinnitus in rats and both central and peripheral auditory systems participate in the generation of salicylate-induced tinnitus.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
authors.forename: Guanyin
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Clinical Medicine, Faculty of Aerospace medicine, the Fourth Military Medical University, Xi'an, China.
authors.forename: Lining
authors.initials: L
authors.lastname: Feng
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
authors.forename: Yongzhu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Radiology, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
authors.forename: Haifeng
authors.initials: H
authors.lastname: Chang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Cui
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003056:Cochlear Nerve / Q000293:injuries; D003216:Conditioning, Operant / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D060766:Drinking Water; D016057:Evoked Potentials, Auditory, Brain Stem; D007274:Injections, Intraperitoneal; D008297:Male; D008839:Microelectrodes; D046709:Pattern Recognition, Physiological; D051381:Rats; D017207:Rats, Sprague-Dawley; D020156:Salicylic Acid / Q000009:adverse effects*; D014012:Tinnitus / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D060766:Drinking Water; D020156:Salicylic Acid