title: Kernel based support vector machine for the early detection of syncope during head-up tilt test.
abstract: This study aims to analyze the autonomic nervous system response during head-up tilt test (HUTT), by exploring the changes in dynamic properties of heart rate variability in subjects with and without syncopes, to predict the outcome of HUTT. Baroreflex response, as well as linear and non-linear parameters of RR-interval time series, have been extracted from the ECG of 66 subjects: 35 with and 31 without syncope during HUTT. The results show that, when considering the first 15 min of tilting position, the total power spectrum, the standard deviation, the long-term fractal scale of RR-interval and ΔRR-interval of time series increase, while the sample entropy decreases in the positive group compared to the negative one. These indices may be good predictors of positive response in patients with reflex syncope. Additionally, an analysis of the first 15 min of tilting position using kernel support vector machines leads to a correct classification of 85% of patients, within negative and positive response groups (specificity = 80.6% and sensitivity = 88.5%). In medical applications, it is important to avoid false negative diagnosis of syncopes during HUTT. Taking this into account, an overall accuracy of 72.1% can be obtained in the same window allowing the reduction of the examination time in the clinical domain.
authors.affiliation: Azm Platform for Research in Biotechnology and its Applications, LASTRE Laboratory, Lebanese University, Tripoli, Lebanon. INSERM, U1099, Rennes, F-35000, France and Université de Rennes 1, LTSI, Rennes, F-35000, France.
authors.forename: N
authors.initials: N
authors.lastname: Khodor
authors.forename: D
authors.initials: D
authors.lastname: Matelot
authors.forename: G
authors.initials: G
authors.lastname: Carrault
authors.forename: H
authors.initials: H
authors.lastname: Amoud
authors.forename: M
authors.initials: M
authors.lastname: Khalil
authors.forename: N
authors.initials: N
authors.lastname: Ville
authors.forename: F
authors.initials: F
authors.lastname: Carre
authors.forename: A
authors.initials: A
authors.lastname: Hernandez
mesh_terms: D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D057225:Data Mining; D042241:Early Diagnosis; D004562:Electrocardiography; D006801:Humans; D008297:Male; D060388:Support Vector Machine; D013575:Syncope / Q000175:diagnosis* / Q000503:physiopathology; D018667:Tilt-Table Test; D055815:Young Adult