title: Outcomes of combined liver-kidney transplantation in children: analysis of the scientific registry of transplant recipients.
abstract: Combined liver-kidney transplantation (CLKT) in children is uncommon and outcomes have not been well defined. Using the Scientific Registry of Transplant Recipients, data were analyzed on 152 primary pediatric CLKTs performed from October 1987 to February 2011, to determine their outcome in the largest series reported to date. Patient survival was 86.8%, 82.1% and 78.9% at 1, 5 and 10 years, liver graft survival was 81.9%, 76.5% and 72.6%, and kidney graft survival was 83.4%, 76.5% and 66.8%. By way of comparison, the Registry was queried for pediatric patient survival following isolated liver transplantation (LT) during the same time frame: 86.7%, 81.2% and 77.4% and following isolated kidney transplant (KT): 98.2%, 95.4% and 90% at 1, 5 and 10 years. In patients having undergone CLKT, primary hyperoxaluria was associated with reduced patient (p = 0.01), liver graft (p = 0.01) and kidney graft survival (p = 0.01). Furthermore, graft outcome following CLKT improved over the past decade (p = 0.04 for liver, p = 0.02 for kidney), but this did not translate into improved patient outcome (p = 0.2). All in all, our results confirmed that survival following LT was less than following KT, and that CLKT offered similar patient survival to isolated LT.
authors.affiliation: Division of Pediatric Surgery, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: A M
authors.initials: AM
authors.lastname: Calinescu
authors.forename: B E
authors.initials: BE
authors.lastname: Wildhaber
authors.forename: A
authors.initials: A
authors.lastname: Poncet
authors.forename: C
authors.initials: C
authors.lastname: Toso
authors.forename: V A
authors.initials: VA
authors.lastname: McLin
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006530:Hepatorenal Syndrome / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012042:Registries; D012307:Risk Factors; D015996:Survival Rate; D066027:Transplant Recipients; D055815:Young Adult
keywords: Clinical research/practice; graft survival; kidney transplantation/nephrology; liver transplantation/hepatology; patient survival