title: Risk factors for death during pulmonary tuberculosis treatment in Korea: a multicenter retrospective cohort study.
abstract: The data regarding risk factors for death during tuberculosis (TB) treatment are inconsistent, and few studies examined this issue in Korea. The purpose of this study was to evaluate baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea. A multicenter retrospective cohort study of 2,481 patients who received TB treatment at eight hospitals from January 2009 to December 2010 was performed. Successful treatment included cure (1,129, 45.5%) and treatment completion (1,204, 48.5%) in 2,333 patients (94.0%). Unsuccessful treatment included death (85, 3.4%) and treatment failure (63, 2.5%) occurred in 148 patients (6.0%). In multivariate analysis, male sex, anemia, dyspnea, chronic heart disease, malignancy, and intensive care unit (ICU) admission were significant risk factors for death during TB treatment. Therefore, male sex, anemia, dyspnea, chronic heart disease, malignancy, and ICU admission could be baseline prognostic factors for death during treatment of adult patients with pulmonary TB in Korea.
authors.affiliation: Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.
authors.forename: Yong-Soo
authors.identifier: 0000-0001-5121-4488
authors.initials: YS
authors.lastname: Kwon
authors.affiliation: Department of Pulmonary and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Yee Hyung
authors.identifier: 0000-0002-2921-0314
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Jae-Uk
authors.identifier: 0000-0002-0181-0844
authors.initials: JU
authors.lastname: Song
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyeongman
authors.identifier: 0000-0002-4822-1772
authors.initials: K
authors.lastname: Jeon
authors.affiliation: Division of Pulmonology, Samsung Changwon Hospital, Changwon, Korea.
authors.forename: Junwhi
authors.identifier: 0000-0002-8760-7627
authors.initials: J
authors.lastname: Song
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Ewha Medical Center and Ewha Medical Research Institute, Ewha Womans University School of Medicine, Mokdong Hospital, Seoul, Korea.
authors.forename: Yon Ju
authors.identifier: 0000-0003-4059-9401
authors.initials: YJ
authors.lastname: Ryu
authors.affiliation: Department of Internal Medicine, Chung-Ang University School of Medicine, Seoul, Korea.
authors.forename: Jae Chol
authors.identifier: 0000-0002-8761-6494
authors.initials: JC
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, College of Medicine, Gyeongsang Institute of Health Sciences, Gyeongsang National University, Jinju, Korea.
authors.forename: Ho Cheol
authors.identifier: 0000-0002-3262-0672
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Won-Jung
authors.identifier: 0000-0002-4756-3527
authors.initials: WJ
authors.lastname: Koh
mesh_terms: D000328:Adult; D000368:Aged; D000740:Anemia / Q000150:complications; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D004417:Dyspnea / Q000150:complications; D005260:Female; D006331:Heart Diseases / Q000150:complications; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000150:complications; D011379:Prognosis; D056910:Republic of Korea; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality
chemical_list: D000995:Antitubercular Agents
keywords: Mortality, Korea; Therapeutics; Tuberculosis, Pulmonary