title: Camellia sinensis (L.) Kuntze Extract Ameliorates Chronic Ethanol-Induced Hepatotoxicity in Albino Rats.
abstract: The goal of this study was to investigate the hepatoprotective effects of aqueous extract of Camellia sinensis or green tea extract (AQGTE) in chronic ethanol-induced albino rats. All animals were divided into 4 groups in the study for a 5-week duration. 50% ethanol was given orally to the rats with two doses (5 mg/kg bw and 10 mg/kg bw) of AQGTE. Ethanol administration caused a significant increase in the levels of plasma and serum enzymatic markers, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), and nonenzymatic markers (cholesterol and triglycerides), lipid peroxidation contents, malondialdehyde (MDA), and glutathione-S-transferase (GST), and decreased the activities of total proteins, albumin, and cellular antioxidant defense enzymes such as superoxide dismutase (SOD). The elevation and reduction in these biochemical enzymes caused the damage in hepatocytes histologically due to the high production of ROS, which retards the antioxidant defense capacity of cell. AQGTE was capable of recovering the level of these markers and the damaged hepatocytes to their normal structures. These results support the suggestion that AQGTE was able to enhance hepatoprotective and antioxidant effects in vivo against ethanol-induced toxicity.
authors.affiliation: Environmental Endocrinology and Biomedical Research Unit, Department of Zoology, Meerut College, Meerut 250003, India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Lodhi
authors.affiliation: Scientific and Applied Research Center, Meerut 250001, India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Tandan
authors.affiliation: Environmental Endocrinology and Biomedical Research Unit, Department of Zoology, Meerut College, Meerut 250003, India.
authors.forename: Neera
authors.initials: N
authors.lastname: Singh
authors.affiliation: D.A.V. (P.G.) College, Bulandshahr 203001, India.
authors.forename: Divyansh
authors.initials: D
authors.lastname: Kumar
authors.affiliation: Scientific and Applied Research Center, Meerut 250001, India.
authors.forename: Monu
authors.initials: M
authors.lastname: Kumar