title: [Effects of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions].
abstract: OBJECTIVE
  To investigate the effect of cetylpyridinium chloride buccal tablets on halitosis induced by oral conditions.
  
  
  METHODS
  With Porphyromonas gingivalis, Prevotella intermedia and Fusobacterium nucleatum as the testing bacteria, the minimal inhibitory concentration (MIC) of cetylpyridinium chloride buccal tablets was determined using minute amount serial dilution test. The production of volatile sulfur compounds (VSCs) was measured using sulfide detector halimeter in the anaerobic bacteria culture at 4 and 8 h after addition of the tablets. The effect of the tablets in suppressing odor production by mouth-borne halitosis bacteria was assessed using cysteine challenge test in healthy volunteers, and the effectiveness was evaluated by measuring the reduction in VSCs production and the duration of the effect.
  
  
  RESULTS
  Cetylpyridinium chloride buccal tablets inhibited the growth of all the 3 bacteria. The tablets obviously inhibited VSCs production by the 3 bacteria with a effect similar to chlorhexidine. Compared with distilled water gargle, the buccal tablets significantly reduced cysteine-induced VSCs production level in the healthy volunteers (P<0.05), and the effect lasted for 230 min.
  
  
  CONCLUSIONS
  Cetylpyridinium chloride tablets can obviously suppress bacteria responsible for oral halitosis and produce good effects in the treatment of halitosis induced by oral conditions.
authors.affiliation: epartment of Implantology, Affiliated Stomatological Hospital of Southern Medical University/Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China. E-mail: 1194479077@qq.com.
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Liu
authors.forename: Jincai
authors.initials: J
authors.lastname: Zhang
authors.forename: Dehong
authors.initials: D
authors.lastname: Cai
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Yang
authors.forename: Shiyi
authors.initials: S
authors.lastname: Li
authors.forename: Huilan
authors.initials: H
authors.lastname: Zhong
mesh_terms: D002594:Cetylpyridinium / Q000627:therapeutic use*; D016967:Fusobacterium nucleatum / Q000187:drug effects; D006209:Halitosis / Q000188:drug therapy*; D006801:Humans; D008826:Microbial Sensitivity Tests; D016966:Porphyromonas gingivalis / Q000187:drug effects; D018713:Prevotella intermedia / Q000187:drug effects; D013457:Sulfur Compounds / Q000032:analysis; D013607:Tablets; D055549:Volatile Organic Compounds / Q000032:analysis
chemical_list: D013457:Sulfur Compounds; D013607:Tablets; D055549:Volatile Organic Compounds; D002594:Cetylpyridinium