title: Impact of circulating levels of total and bioavailable serum vitamin D on pregnancy rate in egg donation recipients.
abstract: OBJECTIVE
  To investigate the correlation between total and bioavailable serum 25-OH vitamin D and the pregnancy rate in recipients of donated oocytes.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University-affiliated private IVF center.
  
  
  METHODS
  A total of 267 patients who were referred to our clinic for oocyte donation from June 2013 to December 2013.
  
  
  METHODS
  Serum analysis of vitamin D and bioavailable vitamin D and reproductive outcomes.
  
  
  METHODS
  Pregnancy and implantation rate.
  
  
  RESULTS
  Among all patients, 15.3% (n = 41) were vitamin D replete (vitamin D >30 ng/mL), 50.2% (n = 134) had vitamin D deficiency (20-30 ng/mL), and 34.4% (n = 92) had insufficient vitamin D (<20 ng/mL). Implantation rates were similar among patients with normal, insufficient, or deficient total serum 25-OH vitamin D levels (61%, 63.4%, and 65.2%, respectively). Pregnancy rates did not differ among the three groups (70%, 69.9%, and 73.9%). Ongoing pregnancy rates were also comparable among the three groups (55.9%, 52.7%, and 60.7%). The predictive value of total vitamin D regarding pregnancy rate was analyzed by the receiver operating characteristic curve, and the area under the curve (AUC) was 0.468. The AUC for bioavailable 25-OH vitamin D was 0.499, showing that the analysis of the AUC for vitamin D or bioavailable vitamin D was not informative.
  
  
  CONCLUSIONS
  Vitamin D insufficiency and deficiency are frequent conditions in our southern European infertile population. In contrast to previous studies, patients who are not vitamin D replete do not have a decreased chance of becoming pregnant with egg donation. Bioavailable 25-OH vitamin D, which is a better marker of the status than total 25-OH vitamin D, does not correlate with pregnancy rate in recipients of donated oocytes. Thus, at this stage, there is insufficient evidence to recommend vitamin D screening in patients undergoing egg donation.
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Alberta
authors.initials: A
authors.lastname: Fabris
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Pacheco
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Cruz
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Puente
authors.affiliation: Nova IVI Fertility, Abu Dhabi, United Arab Emirates.
authors.forename: Human
authors.initials: H
authors.lastname: Fatemi
authors.affiliation: IVI-Madrid, Rey Juan Carlos University, Madrid, Spain. Electronic address: juan.garcia.velasco@ivi.es.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garcia-Velasco
mesh_terms: D000328:Adult; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D018873:Pregnancy Rate; D012372:ROC Curve; D012189:Retrospective Studies; D014807:Vitamin D / Q000097:blood* / Q000493:pharmacokinetics; D014808:Vitamin D Deficiency / Q000503:physiopathology*
chemical_list: D014807:Vitamin D
keywords: Oocyte donation; pregnancy rate; vitamin D