title: Examination of the role of galectins during in vivo angiogenesis using the chick chorioallantoic membrane assay.
abstract: Angiogenesis is a complex multi-process involving various activities of endothelial cells. These activities are influenced in vivo by environmental conditions like interactions with other cell types and the microenvironment. Galectins play a role in several of these interactions and are therefore required for proper execution of in vivo angiogenesis. In this chapter we describe a method to study galectins and galectin inhibitors during physiologic and pathophysiologic angiogenesis in vivo using the chicken chorioallantoic membrane (CAM) assay.
authors.affiliation: Angiogenesis Laboratory Amsterdam, Department of Radiation Oncology, VU University medical center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
authors.forename: Esther A
authors.initials: EA
authors.lastname: Kleibeuker
authors.forename: Iris A E
authors.initials: IA
authors.lastname: Schulkens
authors.forename: Kitty C M
authors.initials: KC
authors.lastname: Castricum
authors.forename: Arjan W
authors.initials: AW
authors.lastname: Griffioen
authors.forename: Victor L J L
authors.initials: VL
authors.lastname: Thijssen
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000098:blood supply* / Q000166:cytology / Q000187:drug effects*; D042783:Endothelial Cells; D037161:Galectins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D012995:Solubility
chemical_list: D037161:Galectins