title: Effect of delta sleep-inducing peptide on the expression of antioxidant enzyme genes in the brain and blood of rats during physiological aging.
abstract: Subcutaneous injections of exogenous delta sleep-inducing peptide in a dose of 100 μg/kg (monthly, 5-day courses) to rats of various age groups (2-24 months) were followed by an increase in the expression of genes for SOD 1 (Sod1) and glutathione peroxidase 1 (Gpx1) in the brain and nucleated blood cells. The expression of these genes was shown to decrease during physiological aging of the body.
authors.affiliation: South Federal University, Rostov-on-Don, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Kutilin
authors.forename: T I
authors.initials: TI
authors.lastname: Bondarenko
authors.forename: I V
authors.initials: IV
authors.lastname: Kornienko
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
mesh_terms: D000375:Aging / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D003701:Delta Sleep-Inducing Peptide; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase