title: Investigation on malondialdehyde, S100B, and advanced oxidation protein product levels in significant hyperbilirubinemia and the effect of intensive phototherapy on these parameters.
abstract: BACKGROUND
  The parameters of oxidative stress [advanced oxidation protein products (AOPPs), malondialdehyde (MDA), and S100B] and the effect of intensive phototherapy (PT) on these parameters have not been studied extensively in newborns with significant hyperbilirubinemia (SH). We aimed to measure the levels of MDA, S100B, and AOPPs in newborns with SH, and to compare newborns with healthy control newborns without hyperbilirubinemia on the basis of these parameters of oxidative stress. In addition, we investigated the effect of intensive PT on these parameters during the treatment of SH and report our findings for the first time in the literature.
  
  
  METHODS
  The study was performed in newborns (n = 62) who underwent intensive PT because of SH. Newborns without jaundice constituted the control group (n = 30). Both groups were compared with respect to demographic characteristics and biochemical (laboratory) parameters including MDA, AOPPs, and S100B. MDA, AOPPs, and S100B were also compared before and after intensive PT in the PT group. In the study group, a correlation analysis of demographic characteristics; MDA, AOPP, and S100B values; and changes occurring in MDA, AOPPs, and S100B values due to the effect of intensive PT was performed.
  
  
  RESULTS
  Serum total bilirubin, S100B, and MDA levels in the PT group before performing PT were significantly higher than those in the control group. In newborns receiving PT serum total bilirubin, MDA and AOPP levels decreased significantly after intensive PT. In correlation analysis, a statistically significant negative correlation was found only between the amount of bilirubin decrease with PT and AOPP levels after PT in the study group.
  
  
  CONCLUSIONS
  Whether the significant decrease in MDA levels, which was higher prior to PT, is due to the decrease in serum bilirubin levels or due to the effect of intensive PT itself remains to be determined in further studies. The decrease in AOPP levels after PT implies that intensive PT has protective effects on oxidative stress.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey. Electronic address: drdilekcoban@yahoo.com.tr.
authors.forename: Dilek
authors.initials: D
authors.lastname: Sarici
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Gunes
authors.affiliation: Department of Biochemistry, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Cevat
authors.initials: C
authors.lastname: Yazici
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Mustafa Ali
authors.initials: MA
authors.lastname: Akin
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Korkmaz
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Seyma
authors.initials: S
authors.lastname: Memur
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kurtoglu
authors.affiliation: Division of Neonatology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.
authors.forename: Mehmet Adnan
authors.initials: MA
authors.lastname: Ozturk
authors.affiliation: Division of Neonatology, Department of Pediatrics, Ufuk University Faculty of Medicine, Ankara, Turkey.
authors.forename: Serdar Umit
authors.initials: SU
authors.lastname: Sarici
mesh_terms: D062107:Advanced Oxidation Protein Products / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood* / Q000628:therapy*; D007231:Infant, Newborn; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D010789:Phototherapy; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*
chemical_list: D062107:Advanced Oxidation Protein Products; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D008315:Malondialdehyde
keywords: S100B protein; advanced oxidation protein product; hyperbilirubinemia; intensive phototherapy; malondialdehyde