title: Rhodium-catalyzed regioselective C-H chlorination of 7-azaindoles using 1,2-dichloroethane.
abstract: An unexpected rhodium-catalyzed regioselective C-H chlorination of 7-azaindoles was developed using 1,2-dichloroethane (DCE) as a chlorinating agent and 7-azaindole as the directing group. This protocol provides an efficient access to ortho-chlorinated azaindoles with operational simplicity, good functional group tolerance, and a wide substrate scope.
authors.affiliation: Department of Chemistry, Innovative Drug Research Center, Shanghai University , Shanghai 200444, China.
authors.forename: Guangyin
authors.initials: G
authors.lastname: Qian
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Hong
authors.forename: Bingxin
authors.initials: B
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Mao
authors.forename: Bin
authors.initials: B
authors.lastname: Xu