title: Organocatalyzed asymmetric oxidative coupling of α-Csp3-H of tertiary amines to α,β-unsaturated γ-butyrolactam: synthesis of MBH-type products.
abstract: A unique organocatalytic asymmetric oxidative cross-dehydrogenative coupling of a α-Csp(3)-H bond of tertiary amines with α,β-unsaturated γ-butyrolactams to generate Morita-Baylis-Hillman-type products has been realized for the first time. This method provides an efficient way to access a series of α-heterocyclic optically active tetrahydroisoquinoline scaffolds.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University , Guangzhou 510006, P. R. China.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Ma
authors.forename: Gen
authors.initials: G
authors.lastname: Zhang
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Dongxu
authors.initials: D
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D058451:Oxidative Coupling; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D007769:Lactams; D044005:Tetrahydroisoquinolines