title: NF-κB and STAT3 in glioblastoma: therapeutic targets coming of age.
abstract: Since we last addressed the roles of NF-κB and JAK/STAT3 signaling in glioblastoma (GBM) 5 years ago, tremendous strides have been made in the understanding of these two pathways in glioma biology. Contributing to prosurvival mechanisms, cancer stem cell maintenance and treatment resistance, both NF-κB and STAT3 have been characterized as major drivers of GBM. In this review, we address general improvements in the molecular understanding of GBM, the structure of NF-κB and STAT3 signaling, the ways in which these pathways contribute to GBM and advances in preclinical and clinical targeting of these two signaling cascades.
authors.affiliation: Department of Cell, Developmental and Integrative Biology, 1900 University Blvd, THT 926A, University of Alabama at Birmingham, Birmingham, AL, 35294-0006, USA.
authors.forename: G Kenneth
authors.initials: GK
authors.lastname: Gray
authors.forename: Braden C
authors.initials: BC
authors.lastname: McFarland
authors.forename: Susan E
authors.initials: SE
authors.lastname: Nozell
authors.forename: Etty N
authors.initials: EN
authors.lastname: Benveniste
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents; D016328:NF-kappa B; D050796:STAT3 Transcription Factor
keywords: NF-κB; STAT3; glioblastoma; neurotherapeutics; signaling