title: The effect of iron supplement on children with euthyroid goiter: a randomized placebo-controlled clinical trial.
abstract: BACKGROUND
  Endemic goiter is present in most parts of Iran. Iron deficiency adversely affects the physiology of thyroid. The initial steps of thyroid hormone synthesis are catalyzed by thyroperoxidases and are dependent on iron. In many developing countries, children are at high risk of both goiter and iron deficiency anemia. In addition, iron deficiency may alter central nervous system control of thyroid metabolism; andalso Iron-deficiency anemia decreases plasma concentrations of thyroxine and triiodothyronine.
  
  
  METHODS
  We conducted a randomized, double-blind,controlled trial in 2-12-y-old children with euthyroid goiter and without iron-deficiency anemia. THE CHILDREN WEREDIVIDED INTO TWO GROUPS: The Patients who were under treatment with ferrous-sulphat and controls .active treatment consisted of iron supplementation was administered orally with a dose of 2 mg/kg day. The duration of active treatment was 12 weeks.
  
  
  RESULTS
  In this study 40 children (female: 22, male: 18) were divided into two groups randomly. (20 patients in each group).There were no significant differences at baselines between groups with regard to gender, age and weigh. At the end of the study, the reduction of more than one grade of goiter was significant between iron-treated and placebo groups. In treatment group, 16 patients (80%) had decreased grade of goiter, while in the control group, 3 patients (15%) had grade reduction(P-value<0.001).
  
  
  CONCLUSIONS
  At the end of the study, decrease of more than one grade of goiter had significant differences between iron-treated and control groups.
authors.affiliation: Department of Pediatric Hematology oncology and Genetic Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Ordooei
authors.affiliation: Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Akbarzadeh
authors.affiliation: Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Soleimanizad
authors.affiliation: MSc in biostatistics, Department of biostatistics and epidemiology, Faculty of health, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Shamsi
authors.affiliation: Health Policy Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Masoumi Dehshiri
keywords: Iron; goiter; treatment