title: Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus.
abstract: BACKGROUND
  Novel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.
  
  
  METHODS
  Collecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China.
  
  
  RESULTS
  Three cases of human infection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure.
  
  
  CONCLUSIONS
  This novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Nanchang First Hospital, Nanchang, Jiangxi 330008, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wan
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Kejian
authors.initials: K
authors.lastname: Qian
authors.affiliation: Jiangxi Province Center for Disease Control and Prevention, Nanchang, Jiangxi 330038, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Zuke
authors.initials: Z
authors.lastname: Xiao
authors.affiliation: Nanchang University Fourth Affiliated Hospital, Nanchang, Jiangxi 330003, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Zhenguo
authors.initials: Z
authors.lastname: Zeng
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Nanchang First Hospital, Nanchang, Jiangxi 330008, China.
authors.forename: Jinxiang
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Nanchang First Hospital, Nanchang, Jiangxi 330008, China.
authors.forename: Guanghui
authors.initials: G
authors.lastname: Jiang
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Nie
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Nanchang University First Affiliated Hospital, Nanchang, Jiangxi 330006, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: Ding
authors.affiliation: Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Li
authors.affiliation: Oxford University Clinical Research Unit -Wellcome Trust Major Overseas Programme, Hanoi, Vietnam.
authors.forename: Peter
authors.initials: P
authors.lastname: Horby
authors.affiliation: Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China. Email: zcgao@bjmu.edu.cn.
authors.forename: Zhancheng
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D065926:Influenza A Virus, H10N8 Subtype / Q000187:drug effects / Q000472:pathogenicity*; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D053139:Oseltamivir / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D024841:Fluoroquinolones; D053139:Oseltamivir; D015378:Imipenem; D000077266:Moxifloxacin