title: Electroconvulsive in a Schizophrenic Patient With Neuroleptic Malignant Syndrome and Rhabdomyolysis.
abstract: We present the case of a middle-aged man with a chronic history of schizoaffective disorder, depressed type, stable on a second-generation antipsychotic. Psychotic symptoms recurred contingent to medication noncompliance necessitating hospitalization. Treatment was complicated by the development of neuroleptic malignant syndrome (NMS). In addition, subsequent medication rechallenges failed because of recurrent rhabdomyolysis and atypical NMS. Electroconvulsive therapy (ECT) treatment was initiated, affording remission of psychotic symptoms and nonrecurrence of NMS and rhabdomyolysis. Our experience confirmed the efficacy of ECT treatment in providing symptom relief of psychosis complicated by recurrent episodes of NMS and atypical NMS. Likewise, it illustrated the efficacy of ECT treatment for rhabdomyolysis.
authors.affiliation: From the Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Elmhurst Hospital Center, Elmhurst, NY.
authors.forename: Maria Chona P
authors.initials: MC
authors.lastname: San Gabriel
authors.forename: Bharathi
authors.initials: B
authors.lastname: Eddula-Changala
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Tan
authors.forename: Carrol T
authors.initials: CT
authors.lastname: Longshore
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects; D004565:Electroconvulsive Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D009459:Neuroleptic Malignant Syndrome / Q000150:complications*; D000077152:Olanzapine; D010349:Patient Compliance; D012206:Rhabdomyolysis / Q000150:complications*; D012559:Schizophrenia / Q000150:complications* / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D003024:Clozapine; D000077152:Olanzapine