title: Effect of aerobic exercise and fish oil supplements on plasma levels of inflammatory indexes in mice.
abstract: BACKGROUND
  Exercise has positive and negative effects on immune system. Herein, we would like to investigate the effects of incremental aerobic training and fish oil supplementation on the plasma levels of CRP, CPK and IL-17 in trained mice. One of the major roles of immune system is to produce soluble or cellular components that provide the immunity against inflammatory agent. The purpose of this study is to investigate distinct and combine effects of incremental aerobic training and fish oil supplement on plasma levels of IL-17, CPK and CRP in trained male mice.
  
  
  METHODS
  Totally, 54 healthy male mice (2 months old, weight= 34±1 grams) were selected. At first 10 mice were killed to determine base line values, the rest of them were randomly divided into four groups, control group (C, n=11), supplement group (S, n=11), training group (T, n=11) and supplement-training group (ST, n=11).The supplement and supplement-training groups were fed with 0.2cc/day fish oil for 8 weeks. Training and supplement-training groups underwent exercise for 5 sessions per week for a period of 8 weeks on animal treadmill. SPSS 16.0 software and multivariate analysis of variance were used for statistical analysis of data
  
  
  RESULTS
  Exercise and fish oil supplement lead to a decrease in CRP levels and subsequently causing a reduction in plasma levels of IL-17 and CK in mice (p<0.05).
  
  
  CONCLUSIONS
  Combination of exercise and fish oil can reduce regulate inflammatory response caused by incremental exercise.
authors.affiliation: 1. PhD Student of Exercise Physiology, Exercise Physiology Department, Mazandaran University, Mazandaran, Iran. halizadeh327@gmail.com .
authors.forename: Hamid
authors.initials: H
authors.lastname: Alizadeh
authors.affiliation: 2. PhD student, Exercise Physiology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran. bazgirbehzad@yahoo.com.
authors.forename: Behzad
authors.initials: B
authors.lastname: Bazgir
authors.affiliation: 3. Assistant Professor of Sport Physiology, Department of Physical Education, Shiraz University, Shiraz, Iran. daryanooshf@yahoo.com.
authors.forename: Farhad
authors.initials: F
authors.lastname: Daryanoosh
authors.affiliation: 4. Assistant Professor of Sport Physiology, Department of Physical Education, Shiraz University, Shiraz, Iran. koushki53@yahoo.com.
authors.forename: Maryam
authors.initials: M
authors.lastname: Koushki
authors.affiliation: 5. Assistant Prof. Sport Medicine, Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. sobhani515@yahoo.com.
authors.forename: Vahid
authors.initials: V
authors.lastname: Sobhani
keywords: CPK; CRP; Fish oil supplement; IL -17; Inflammation