title: Random-start controlled ovarian hyperstimulation with letrozole for fertility preservation in cancer patients: case series and review of literature.
abstract: The aim of this case series was to describe our experience with random-start controlled ovarian hyperstimulation (RS-COH) with the use of letrozole for fertility preservation. GnRH antagonist and letrozole cycles were started in three patients with a diagnosis of cancer and had a limited time window for fertility preservation for COH before initiating cancer therapy. Cycles were started in the late follicular or luteal phase, and the duration of COH ranged between 7-8 days. A total of 4-14 oocytes were retrieved, the peak E2 levels were 252-354 pg/ml and the saved time for start of the cancer treatment were 16-26 days for each patient. In conclusion, RS-COH with letrozole cycle is a reasonable option for fertility preservation in cancer patients for whom the treatment window may be narrow. Also, the use of a letrozole for COH may decrease the potential risk of ovarian hyperstimulation syndrome.
authors.forename: Ugur
authors.initials: U
authors.lastname: Keskin
authors.forename: Cihangir Mutlu
authors.initials: CM
authors.lastname: Ercan
authors.forename: Ali
authors.initials: A
authors.lastname: Yilmaz
authors.forename: Ali
authors.initials: A
authors.lastname: Babacan
authors.forename: Cem
authors.initials: C
authors.lastname: Korkmaz
authors.forename: Namik Kemal
authors.initials: NK
authors.lastname: Duru
authors.forename: Ali
authors.initials: A
authors.lastname: Ergun
mesh_terms: D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D001943:Breast Neoplasms; D018270:Carcinoma, Ductal, Breast; D005260:Female; D059247:Fertility Preservation / Q000379:methods*; D006801:Humans; D000077289:Letrozole; D008228:Lymphoma, Non-Hodgkin; D009570:Nitriles / Q000627:therapeutic use*; D054315:Oocyte Retrieval; D010051:Ovarian Neoplasms; D010062:Ovulation Induction / Q000379:methods*; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole