title: Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?
abstract: In this perspective review, we focalized our attention on the application of cyclotides in drug discovery. To date, two principal approaches have been explored since now: (i) the use of cyclotides as scaffold in which bioactive peptides can be grafted to improve stability, oral bioactivity and binding to GPCRs; (ii) their application as natural peptides library. For these reasons, cyclotides probably represent today a step further in the development of new tools in drug design.
authors.affiliation: Dipartimento di Farmacia, Università di Chieti-Pescara "G. d'Annunzio" , Chieti , Italy .
authors.forename: Adriano
authors.initials: A
authors.lastname: Mollica
authors.forename: Roberto
authors.initials: R
authors.lastname: Costante
authors.forename: Azzurra
authors.initials: A
authors.lastname: Stefanucci
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
mesh_terms: D020650:Combinatorial Chemistry Techniques; D047169:Cyclotides / Q000737:chemistry* / Q000494:pharmacology; D019151:Peptide Library; D013329:Structure-Activity Relationship
chemical_list: D047169:Cyclotides; D019151:Peptide Library
keywords: Cyclic peptides; cyclotides; peptides