title: Evaluation of postural parathyroid hormone change in patients with primary hyperparathyroidism.
abstract: Purpose. In the present study, we aimed to investigate postural change of PTH in normal individuals and in patients with primary hyperparathyroidism (PHPT). Methods. Twenty-two patients with PHPT and nine healthy controls were enrolled. Following 12 h of fast, patients stayed in recumbent position for an hour and PTH and total Ca measurements were performed at the 45th and 60th minutes of resting. Afterwards, the patients resumed an upright posture for an hour and again blood samples were taken at the 45th and 60th minutes of standing. Results. In the PHPT group, mean PTH was calculated as 153.9 pg/mL in the recumbent position while it was 206.3 during upright position (Δ change was 47.7) (P < 0.001). In the control group mean serum PTH was measured as 41.2 pg/mL in the recumbent position while it was 44.8 pg/mL in the upright position (Δ change was 1.7) (P = 0.11). In both groups, serum Ca was higher in the upright position compared to the recumbent position (P < 0.001). Conclusion. Postural change of serum PTH is significant only in PHPT group. Postural PTH test may give a clue to the clinician when the diagnosis of PHPT is equivocal.
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Cevdet
authors.identifier: 0000-0003-2081-2885
authors.initials: C
authors.lastname: Aydin
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Sefika Burcak
authors.initials: SB
authors.lastname: Polat
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirikoc
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Ogmen
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Cuhaci
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Ersoy
authors.affiliation: Endocrinology and Metabolism Department, Ataturk Education and Research Hospital, Yildirim Beyazit University, 06800 Ankara, Turkey.
authors.forename: Bekir
authors.initials: B
authors.lastname: Cakir