title: Research of dose-effect relationship parameters of percutaneous microwave ablation for uterine leiomyomas--a quantitative study.
abstract: Eighty eight patients with 91 uterine leiomyomas who underwent ultrasound-guided percutaneous microwave ablation (PMWA) treatment were prospectively included in the study in order to study the dose-effect relationship parameters (DERP) of PMWA for uterine leiomyomas and its relationship with T2-weighted MR imaging (T2WI). Based on the signal intensity of T2WI, uterine leiomyomas were classified as hypointense, isointense, and hyperintense. During ablation, leiomyomas were treated with quantitative microwave ablation (QMWA) energy of 50 w × 300 s or 60 w × 300 s. After QMWA, contrast-enhanced ultrasound (CEUS) was performed to evaluate DERP. No matter under 50 w × 300 s or 60 w × 300 s, quantitative microwave ablation volume (QMAV) of hyperintense leiomyoma was smaller than that of hypointense and isointense leiomyoma (P<0.016). For hypointense and isointense leiomyoma, QMAV of 60 w × 300 s was larger than that of 50 w × 300 s (P<0.05). DERPs obtained by T2WI can be used to guide the treatment of uterine leiomyoma by PMWA.
authors.affiliation: 1] Department of Interventional Ultrasound, Chinese PLA General Hospital [2] Current address: Department of Ultrasound, Beijing Friendship Hospital, Capital Medical University.
authors.forename: Ma
authors.initials: M
authors.lastname: Xia
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jing
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Han
authors.initials: H
authors.lastname: Zhi-yu
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Hao
authors.initials: H
authors.lastname: Yan-li
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Xu
authors.initials: X
authors.lastname: Chang-tao
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Xu
authors.initials: X
authors.lastname: Rui-fang
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Bing-song
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital.
authors.forename: Dong
authors.initials: D
authors.lastname: Bao-wei
mesh_terms: D000328:Adult; D003287:Contrast Media / Q000627:therapeutic use; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D011859:Radiography; D016896:Treatment Outcome; D014599:Uterus / Q000473:pathology / Q000528:radiation effects*
chemical_list: D003287:Contrast Media