title: The evolutionarily conserved multifunctional glycine-rich RNA-binding proteins play key roles in development and stress adaptation.
abstract: The class IV glycine-rich RNA-binding proteins are a distinct subgroup within the heterogenous superfamily of glycine-rich proteins (GRPs). They are distinguished by the presence of an RNA-binding domain in the N-terminus; generally in the form of an RNA-recognition motif (RRM) or a cold-shock domain (CSD). These are followed by a C-terminal glycine-rich domain. Growing evidence suggests that these proteins play key roles in the adaptation of organisms to biotic and abiotic stresses including those resulting from pathogenesis, alterations in the osmotic, saline and oxidative environment and changes in temperature. Similar vertebrate proteins are also cold-induced and involved in, e.g. hibernation, suggesting evolutionarily conserved functions. The class IV RNA-binding GRPs are likely to operate as key molecular components of hormonally regulated development and to work by regulating gene expression at multiple levels by modifying alternative splicing, mRNA export, mRNA translation and mRNA degradation.
authors.affiliation: University of Agricultural Science and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, 400372, Romania; Molecular Cell Physiology, Faculty of Biology, Bielefeld University, Bielefeld, D-33615, Germany.
authors.forename: Oana
authors.initials: O
authors.lastname: Ciuzan
authors.forename: John
authors.initials: J
authors.lastname: Hancock
authors.forename: Doru
authors.initials: D
authors.lastname: Pamfil
authors.forename: Ian
authors.initials: I
authors.lastname: Wilson
authors.forename: Michael
authors.initials: M
authors.lastname: Ladomery
mesh_terms: D000222:Adaptation, Physiological; D000595:Amino Acid Sequence; D017360:Arabidopsis / Q000235:genetics* / Q000254:growth & development / Q000502:physiology; D005075:Biological Evolution; D018506:Gene Expression Regulation, Plant; D005998:Glycine / Q000378:metabolism; D008954:Models, Biological; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D016415:Sequence Alignment
chemical_list: D010940:Plant Proteins; D016601:RNA-Binding Proteins; D005998:Glycine