title: Hypoxic guard systems do not prevent rapid hypoxic inspired mixture formation.
abstract: Because a case report and theoretical mass balances suggested that hypoxic guard systems may not prevent the formation of hypoxic inspired mixtures (FIO2 ≤ 21 %) over the clinically used fresh gas flow (FGF) range, we measured FIO2 over a wide range of hypoxic guard limits for O2/N2O and O2/air mixtures. After IRB approval, 16 ASA I-II patients received sevoflurane in either O2/N2O (n = 8) or O2/air (n = 8) using a Zeus(®) anesthesia machine in the conventional mode. After using an 8 L/min FGF with FDO2 = 25% for 10 min, the following hypoxic guard limits were tested for 4 min each, expressed as [total FGF in L/min; FDO2 in %]: [0.3;85], [0.4;65], [0.5;50], [0.7;36], [0.85;30], [1.0;25], [1.25;25], [1.5;25], [2;25], [3;25], [5;25], and [8;25]. In between these [FGF;FDO2] combinations, 8 L/min FGF with 25% O2 was used for 4 min to return to the same baseline FIO2 (25%) before the start of the next combination. This sequence was studied once in each patient receiving O2/air (n = 8), but twice in each patient who received O2/N2O (n = 8) to examine the effect of decreasing N2O uptake over time, resulting in three groups: early O2/N2O, late O2/N2O, and O2/air group. The [FGF;FDO2]-FIO2 relationship was examined. The overall [FGF;FDO2]-FIO2 relationship in the three groups was similar. In all 1, 1.25, and 1.5 L/min FGF groups, FIO2 decreased below 21% in all but one patient; this occurred within 1 min in at least one patient. In the 0.7 L/min O2/air group and the 3 L/min late O2/N2O and O2/air groups, FIO2 decreased below 21% in one patient. Current hypoxic guard systems do not reliably prevent a hypoxic FIO2 with O2/N2O and O2/air mixtures, particularly between 0.7 and 3 L/min.
authors.affiliation: Department of Anaesthesia, Kliniek Sint-Jan, Brussels, Belgium.
authors.forename: Sofie
authors.initials: S
authors.lastname: De Cooman
authors.forename: Caroline
authors.initials: C
authors.lastname: Schollaert
authors.forename: Jan F A
authors.initials: JF
authors.lastname: Hendrickx
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Peyton
authors.forename: Tom
authors.initials: T
authors.lastname: Van Zundert
authors.forename: Andre M
authors.initials: AM
authors.lastname: De Wolf
mesh_terms: D000368:Aged; D000388:Air; D000758:Anesthesia / Q000379:methods; D000764:Anesthesia, Closed-Circuit / Q000379:methods; D000769:Anesthesia, Inhalation / Q000379:methods; D000777:Anesthetics; D018685:Anesthetics, Inhalation; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000175:diagnosis / Q000517:prevention & control*; D008738:Methyl Ethers / Q000627:therapeutic use; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000295:instrumentation* / Q000379:methods*; D010100:Oxygen / Q000737:chemistry*; D015203:Reproducibility of Results; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D010100:Oxygen