title: Late recurrence of light chain deposition disease after kidney transplantation treated with bortezomib: a case report.
abstract: BACKGROUND
  Light chain deposition disease (LCDD) recurs frequently after renal transplantation with variable presentation.
  
  
  METHODS
  We report the case of a 67-year-old Caucasian female with recurrence of LCDD after living-donor kidney transplantation. Bone marrow biopsy revealed kappa light chain-restricted population of plasma cells, and the patient met the criteria for multiple myeloma. Her renal function progressively worsened and she became dialysis dependent. She received 1 cycle of bortezomib along with intravenous dexamethasone. She was able to discontinue dialysis within 2 months, and at 1 year follow-up her renal function was stable.
  
  
  CONCLUSIONS
  Bortezomib has a role in the treatment of recurrent LCDD and multiple myeloma in kidney transplant patients. As opposed to traditional regimens, a short course may be beneficial.
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA ; The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA.
authors.forename: Abdul
authors.initials: A
authors.lastname: Moiz
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Tariq
authors.initials: T
authors.lastname: Javed
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Garces
authors.affiliation: Department of Nephrology, Ochsner Clinic Foundation, New Orleans, LA ; Multi-Organ Transplant Institute, Ochsner Clinic Foundation, New Orleans, LA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Staffeld-Coit
authors.affiliation: Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN.
authors.forename: Paisit
authors.initials: P
authors.lastname: Paueksakon
keywords: Bortezomib; immunoglobulin light chains; kidney transplantation