title: [Protective properties of recombinant IgA1 protease from meningococcus].
abstract: The study of enzymatic and protective properties of recombinant IgA1 protease in active and mutant form showed that active form of IgA1 protease exhibited species - and type-specificity for mouse and human immunoglobulins. Mutant form, which did not exhibit enzymatic activity, had protective properties against meningococcal infection, induced by meningococcus serogroup A, B and C protecting the mice from lethal infection by living virulent culture of heterologous serogroups of meningococcus. Obtained results make it possible to consider IgA1 protease as a perspective preparation at the stages of development of polyvalent vaccine for protection the people from meningococcal infection of various etiology.
authors.forename: O V
authors.initials: OV
authors.lastname: Kotel'nikova
authors.forename: A P
authors.initials: AP
authors.lastname: Alliluev
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Drozhzhina
authors.forename: I S
authors.initials: IS
authors.lastname: Koroleva
authors.forename: E A
authors.initials: EA
authors.lastname: Sitnikova
authors.forename: A A
authors.initials: AA
authors.lastname: Zinchenko
authors.forename: E A
authors.initials: EA
authors.lastname: Gordeeva
authors.forename: T D
authors.initials: TD
authors.lastname: Melikhova
authors.forename: E A
authors.initials: EA
authors.lastname: Nokel'
authors.forename: L S
authors.initials: LS
authors.lastname: Zhigis
authors.forename: V S
authors.initials: VS
authors.lastname: Zueva
authors.forename: O A
authors.initials: OA
authors.lastname: Razguliaeva
authors.forename: O V
authors.initials: OV
authors.lastname: Serova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Iagudaeva
authors.forename: L D
authors.initials: LD
authors.lastname: Rumsh
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D056738:Cross Protection; D005260:Female; D006801:Humans; D007114:Immunization; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009345:Neisseria meningitidis / Q000276:immunology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D012697:Serine Endopeptidases / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D012703:Serotyping; D022223:Vaccines, Subunit
chemical_list: D001426:Bacterial Proteins; D022401:Meningococcal Vaccines; D011994:Recombinant Proteins; D022223:Vaccines, Subunit; D012697:Serine Endopeptidases; C021433:IgA-specific serine endopeptidase
keywords: IgA1 protease; enzymatic activity; immunogenicity; meningococcal vaccine; protective properties