title: The mitochondrial permeability transition pore: molecular nature and role as a target in cardioprotection.
abstract: The mitochondrial permeability transition (PT) - an abrupt increase permeability of the inner membrane to solutes - is a causative event in ischemia-reperfusion injury of the heart, and the focus of intense research in cardioprotection. The PT is due to opening of the PT pore (PTP), a high conductance channel that is critically regulated by a variety of pathophysiological effectors. Very recent work indicates that the PTP forms from the F-ATP synthase, which would switch from an energy-conserving to an energy-dissipating device. This review provides an update on the current debate on how this transition is achieved, and on the PTP as a target for therapeutic intervention. This article is part of a Special Issue entitled "Mitochondria: from basic mitochondrial biology to cardiovascular disease".
authors.affiliation: Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy; Consiglio Nazionale delle Ricerche Neuroscience Institute, University of Padova, 35121 Padova, Italy. Electronic address: bernardi@bio.unipd.it.
authors.forename: Paolo
authors.initials: P
authors.lastname: Bernardi
authors.affiliation: Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy; Consiglio Nazionale delle Ricerche Neuroscience Institute, University of Padova, 35121 Padova, Italy. Electronic address: dilisa@bio.unipd.it.
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Lisa
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D000081406:Peptidyl-Prolyl Isomerase F; D021983:Cyclophilins / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology; D006801:Humans; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000187:drug effects / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D025261:Mitochondrial Proton-Translocating ATPases / Q000378:metabolism; D010539:Permeability / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D000081406:Peptidyl-Prolyl Isomerase F; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D016572:Cyclosporine; D025261:Mitochondrial Proton-Translocating ATPases; D021983:Cyclophilins
keywords: Ischemia–reperfusion injury; Mitochondria; Permeability transition pore