title: Correlation of fatigue during the acute stage of stroke with serum uric acid and glucose levels, depression, and disability.
abstract: BACKGROUND
  To clarify the correlation of fatigue during the acute stage of stroke with serum uric acid (UA) and glucose levels, depression, and disability.
  
  
  METHODS
  Cross-sectional descriptive study.
  
  
  METHODS
  A stroke group of 312 patients and a reference group of 312 healthy controls were recruited during the same period. Fatigue was assessed using the Fatigue Severity Scale (FSS). Patients with an FSS score ≥4 points were defined as having fatigue. Depression was assessed using the Self-rating Depression Scale (SDS). Patients with an SDS score ≥50 points were defined as having depression. Stroke severity and the level of disability were assessed with the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (MRS).
  
  
  RESULTS
  The prevalence of fatigue in the stroke group was higher than that in the reference group (p < 0.001). Within the stroke group, low serum UA level, high MRS score, high serum glucose level, and high SDS score were associated with increased FSS score. The MRS score was associated most consistently with the FSS score (B = 0.411, 95% CI: 0.297, 0.525). Age, gender, chronic disease history, and NIHSS score were not associated with FSS score.
  
  
  CONCLUSIONS
  Serum UA and glucose levels, depression, and disability are closely related to fatigue during the acute stage of ischaemic stroke.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Weiyu
authors.initials: W
authors.lastname: Teng
authors.forename: Kui
authors.initials: K
authors.lastname: Huang
authors.forename: Xiuli
authors.initials: X
authors.lastname: Shang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003863:Depression / Q000209:etiology*; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005221:Fatigue / Q000209:etiology*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D020521:Stroke / Q000097:blood* / Q000150:complications*; D014527:Uric Acid / Q000097:blood*
chemical_list: D001786:Blood Glucose; D014527:Uric Acid