title: Sulfoximine assisted Pd(II)-catalyzed bromination and chlorination of primary β-C(sp3)-H bond.
abstract: S-methyl-S-2-pyridyl-sulfoximine (MPyS) directed bromination and chlorination of the 1°-β-C(sp(3))-H bond of MPyS-N-amides is realized under the influence of N-Br/Cl-phthalimides and a Pd(II)-catalyst. The sequential halogenation and acetoxylation of α-dimethyl MPyS-N-amides constructs highly functionalized α-trisubstituted aliphatic acid derivatives. The MPyS directing group is cleaved from the halogenated products and recovered.
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad-500046, India.
authors.forename: Raja K
authors.initials: RK
authors.lastname: Rit
authors.forename: M Ramu
authors.initials: MR
authors.lastname: Yadav
authors.forename: Koushik
authors.initials: K
authors.lastname: Ghosh
authors.forename: Majji
authors.initials: M
authors.lastname: Shankar
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo