title: Two new amides from a halotolerant fungus, Myrothecium sp. GS-17.
abstract: Two new amides, named N-acetyl-2,4,10,17-tetrahydroxyheptadecylamine (1) and N-acetyl-3,5,11,18-tetrahydroxyoctadecyl-2-amine (2), were isolated from a halotolerant fungus, Myrothecium sp. GS-17. Their structures were identified on the basis of spectroscopic characteristics. The cancer cell cytotoxicities of two compounds were evaluated, and compound 2 exhibited weak cytotoxicity in HL-60 cell line.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, China Medical University, Shenyang, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Songya
authors.initials: S
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China.
authors.forename: Huaqi
authors.initials: H
authors.lastname: Pan
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Li
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Guan
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Guyue
authors.initials: G
authors.lastname: Liu
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Chunmao
authors.initials: C
authors.lastname: Yuan
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Huiming
authors.initials: H
authors.lastname: Hua
mesh_terms: D000081:Acetamides / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology; D013057:Spectrum Analysis
chemical_list: D000081:Acetamides; D000970:Antineoplastic Agents; D005233:Fatty Alcohols; C000599105:N-acetyl-3,5,11,18-tetrahydroxyoctadecyl-2-amine