title: Optogenetic approaches to study stroke recovery.
abstract: Treatment for stroke is very limited, and potential new therapies are focusing on promoting brain repair and plasticity, as they offer a longer therapeutic time window than the current U.S. Food and Drug Administration approved drug. Functional recovery can occur after stroke, and strategies such as direct brain stimulations that promote recovery are promising. Here we review how selective stimulation of neurons in the motor cortex using optogenetics enhances plasticity mechanisms and promotes functional recovery after stroke.
authors.affiliation: Department of Neurosurgery and Stanford Stroke Center, Stanford University School of Medicine , Stanford, California 94305, United States.
authors.forename: Michelle Y
authors.initials: MY
authors.lastname: Cheng
authors.forename: Eric H
authors.initials: EH
authors.lastname: Wang
authors.forename: Gary K
authors.initials: GK
authors.lastname: Steinberg
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009473:Neuronal Plasticity; D062308:Optogenetics; D010775:Photic Stimulation; D020127:Recovery of Function / Q000502:physiology*; D012243:Rhodopsin / Q000235:genetics / Q000378:metabolism; D020521:Stroke / Q000473:pathology / Q000628:therapy*
chemical_list: D012243:Rhodopsin
keywords: Optogenetics; channelrhodopsin; neurotrophin; plasticity; stroke recovery