title: Final results of a phase II trial for stereotactic body radiation therapy for patients with inoperable liver metastases from colorectal cancer.
abstract: OBJECTIVE
  To evaluate the feasibility and efficacy of stereotactic body radiation therapy (SBRT) in the treatment of colorectal liver metastases.
  
  
  METHODS
  Forty-two patients with inoperable colorectal liver metastases not amenable to radiofrequency ablation (RFA) were treated with SBRT for a total number of 52 lesions. All patients received a total dose of 75 Gy in 3 consecutive fractions. Mean size of the lesions was 3.5 cm (range 1.1-5.4). Toxicity was classified according to the Common Toxicity Criteria version 3.0.
  
  
  RESULTS
  Median follow-up was 24 (range 4-47) months. The progression in field was observed in 5 lesions. Twenty-four months actuarial local control (LC) rate was 91 %. Median overall survival (OS) was 29.2 ± 3.7 months. Actuarial OS rate at 24 months was 65 %. Median progression-free survival was 12.0 ± 4.2 months; 24 months actuarial rate was 35 %. No patients experienced radiation-induced liver disease or grade ≥3 toxicity.
  
  
  CONCLUSIONS
  SBRT represents a feasible alternative for the treatment of colorectal liver metastases not amenable to surgery or other ablative treatments in selected patients, showing optimal LC and promising survival rate.
authors.affiliation: Radiotherapy and Radiosurgery, Oncology, Liver Surgery Departments, Humanitas Clinical and Research Center, Via Manzoni 56, 20089, Rozzano, Milano, Italy, marta.scorsetti@humanitas.it.
authors.forename: Marta
authors.initials: M
authors.lastname: Scorsetti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Comito
authors.forename: Angelo
authors.initials: A
authors.lastname: Tozzi
authors.forename: Pierina
authors.initials: P
authors.lastname: Navarria
authors.forename: Antonella
authors.initials: A
authors.lastname: Fogliata
authors.forename: Elena
authors.initials: E
authors.lastname: Clerici
authors.forename: Pietro
authors.initials: P
authors.lastname: Mancosu
authors.forename: Giacomo
authors.initials: G
authors.lastname: Reggiori
authors.forename: Lorenza
authors.initials: L
authors.lastname: Rimassa
authors.forename: Guido
authors.initials: G
authors.lastname: Torzilli
authors.forename: Stefano
authors.initials: S
authors.lastname: Tomatis
authors.forename: Armando
authors.initials: A
authors.lastname: Santoro
authors.forename: Luca
authors.initials: L
authors.lastname: Cozzi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004307:Dose-Response Relationship, Radiation; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D016634:Radiosurgery / Q000401:mortality*; D015996:Survival Rate