title: Genomic complexity: a call to action.
abstract: Because of their genomic simplicity relative to mature cancers, pre-malignant tissues might harbor therapeutic targets for drugs that destroy cancers before they appear.
authors.affiliation: Janssen Research and Development, Raritan, NJ 08869, USA. whait@its.jnj.com.
authors.forename: William N
authors.initials: WN
authors.lastname: Hait
authors.affiliation: Institute for Advanced Studies, Princeton, New Jersey and The Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Levine
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D058990:Molecular Targeted Therapy; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D057285:Precision Medicine; D011237:Predictive Value of Tests
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor