title: Case of minimal deviation adenocarcinoma: possible clinical link to lobular endocervical glandular hyperplasia as its origin.
abstract: Minimal deviation adenocarcinoma (MDA) is defined as an extremely well differentiated variant of endocervical adenocarcinoma. Several reports have stated that MDA associates with lobular endocervical glandular hyperplasia (LEGH). It is difficult to distinguish LEGH from MDA based on clinical and histologic similarities. There is no definite evidence proving that LEGH is a precursor lesion of MDA. A 45-year-old woman was admitted to our hospital for minute investigation of her neurological disorder. The multiple-cystic lesion at the uterine cervix was identified by magnetic resonance imaging. Based on her normal histological findings and severe underlying conditions, a careful follow-up strategy was adapted. Two years later, atypical glandular cells were observed and the multiple-cystic lesion had increased. Pathological diagnosis of a conization specimen was MDA. Radical hysterectomy was carried out. Pathological examination revealed coexistence of LEGH and MDA. Her clinical course and histological findings suggested the possibility that LEGH might be a precursor lesion of MDA.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Teikyo University, Tokyo, Japan.
authors.forename: Takeru
authors.initials: T
authors.lastname: Sugihara
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Takeshita
authors.forename: Takuya
authors.initials: T
authors.lastname: Ayabe
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007044:Hysterectomy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery
keywords: cancerous precursor lesion; coexistence; lobular endocervical glandular hyperplasia; minimal deviation adenocarcinoma; progression