title: Neutrophil-to-lymphocyte ratio may predict progression in patients with keratoconus.
abstract: OBJECTIVE
  Neutrophil-to-lymphocyte ratio (NLR) is a new potential predictor of systemic inflammation in several diseases. In this study, we aimed to evaluate NLR in patients with keratoconus.
  
  
  METHODS
  This cross-sectional observational study included 54 patients with keratoconus and 25 age- and sex-matched control subjects. All participants underwent a detailed ophthalmological examination and corneal topography. The patients were divided into progressive and nonprogressive keratoconus groups on the basis of topographic parameters. Serum samples were obtained from all subjects, and the NLR was calculated.
  
  
  RESULTS
  The NLR was 3.27 ± 1.37 in the progressive keratoconus group versus 1.87 ± 0.39 and 1.87 ± 0.52 in the nonprogressive and control groups, respectively (P < 0.01). There was a positive correlation between NLR and progression (P < 0.05). In the receiver-operating characteristic analysis, an NLR ≥ 2.24 predicted the presence of progression with 79% sensitivity and 81% specificity.
  
  
  CONCLUSIONS
  The NLR is a simple and inexpensive marker of systemic inflammation. The NLR was found to be higher in patients with progressive keratoconus than in the nonprogressive group and controls.
authors.affiliation: *Department of Ophthalmology, Sorgun State Hospital, Yozgat, Turkey; †Medical Faculty, Department of Ophthalmology, Gazi University, Ankara, Turkey; ‡Medical Faculty, Department of Ophthalmology, Recep Tayyip Erdoğan University, Rize, Turkey; and §Faculty of Science, Department of Statistics, Gazi University, Ankara, Turkey.
authors.forename: Emine Esra
authors.initials: EE
authors.lastname: Karaca
authors.forename: Mehmet Cüneyt
authors.initials: MC
authors.lastname: Özmen
authors.forename: Feyzahan
authors.initials: F
authors.lastname: Ekici
authors.forename: Erdem
authors.initials: E
authors.lastname: Yüksel
authors.forename: Zülal
authors.initials: Z
authors.lastname: Türkoğlu
mesh_terms: D000328:Adult; D015415:Biomarkers; D019781:Corneal Topography; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000175:diagnosis*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D009504:Neutrophils / Q000473:pathology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015415:Biomarkers