title: Miniaturized integrated biosensors.
abstract: Miniaturized integrated thin-film biosensors were developed for use in clinical analyzers and for in vivo applications. A glucose and a lactate sensor were integrated with a pH-sensor on a flexible substrate. Both enzyme sensors are based on the electrochemical measurement of H2O2 produced by the enzymes glucoseoxidase and lactateoxidase respectively. The solid state pH-sensor uses a neutral carrier membrane. The intended application of this device is the monitoring of metabolic parameters in the intensive care unit and the operation theater and the use as a sensor module in clinical analyzers. The glucose-, lactate- and pH-sensor was tested in buffer solutions and undiluted serum showing excellent performance.
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Urban
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: G
authors.initials: G
authors.lastname: Jobst
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: F
authors.initials: F
authors.lastname: Keplinger
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Aschauer
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Fasching
authors.affiliation: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Svasek
keywords: Glucose sensor; Integrated biosensor; Lactate sensor; Thin-film technology; pH-sensor