title: Eurifoloids A-R, structurally diverse diterpenoids from Euphorbia neriifolia.
abstract: Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 μM (SI = 10.3), respectively.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Jin-Xin
authors.initials: JX
authors.lastname: Zhao
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Liu
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Qi
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Han
authors.forename: Ying-Shan
authors.initials: YS
authors.lastname: Han
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wainberg
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors
chemical_list: D019380:Anti-HIV Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D016328:NF-kappa B; C000593731:eurifoloid E; C000593732:eurifoloid F; C530110:ingenane; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1