title: Comparison of Effects of Different Dexmedetomidine and Chloral Hydrate Doses Used in Sedation on Electroencephalography in Pediatric Patients.
abstract: The aim of this study was to compare the efficacy and safety of different oral chloral hydrate and dexmedetomidine doses used for sedation during electroencephalography (EEG) in children. One hundred sixty children aged 1 to 9 years with American Society of Anesthesiologists physical status I-II who were uncooperative during EEG recording or who were referred to our electrodiagnostic unit for sleep EEG were included to the study. The patients were randomly assigned into 4 groups. In groups D1 and D2, patients received oral dexmedetomidine doses of 2 and 3 µg/kg, respectively. In group C1 and C2, patients received oral chloral hydrate doses of 50 and 100 mg/kg, respectively. The induction time was significantly shorter in group C2 compared with other groups (P = .000). The rate of adverse effects was significantly higher in group C2 compared with the dexmedetomidine groups (D1 and D2; P = .004). In conclusion, dexmedetomidine can be used safely for sedation during EEG in children.
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey hakgumus33@yahoo.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Gumus
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Ayşe Kacar
authors.initials: AK
authors.lastname: Bayram
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Hatice Gamze
authors.initials: HG
authors.lastname: Poyrazoglu
authors.affiliation: Department of Anaesthesiology, Erciyes University, Kayseri, Turkey.
authors.forename: Dilek Gunay
authors.initials: DG
authors.lastname: Canpolat
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Per
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Canpolat
authors.affiliation: Department of Anaesthesiology, Erciyes University, Kayseri, Turkey.
authors.forename: Karamehmet
authors.initials: K
authors.lastname: Yildiz
authors.affiliation: Division of Pediatric Neurology, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Sefer
authors.initials: S
authors.lastname: Kumandas
mesh_terms: D058256:Brain Waves / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000627:therapeutic use*; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D007223:Infant; D008297:Male
chemical_list: D006993:Hypnotics and Sedatives; D002697:Chloral Hydrate; D020927:Dexmedetomidine
keywords: chloral hydrate; dexmedetomidine; electroencephalography