title: Impaired oxygen uptake efficiency slope and off-transient kinetics of pulmonary oxygen uptake in sickle cell anemia are associated with hemorheological abnormalities.
abstract: Oxygen uptake efficiency slope (OUES) and excess post-exercise oxygen consumption (EPOC) are markers of physical fitness in the general population but have never been characterized in sickle cell anemia (SCA) where hematological and hemorheological properties are severely altered. Eight SCA patients and eleven healthy subjects (CONT) performed a submaximal incremental exercise conducted until the first ventilatory threshold (VT1). OUES was calculated from the data collected during the incremental period and EPOC parameters (amplitude [A] and time constant [τ]) were calculated from the data measured during exercise recovery. We found that OUES (p = 0.007) and A (p = 0.010) were lower, and τ (p = 0.035) was higher, in SCA patients compared to CONT subjects. OUES and τ were significantly correlated with hematocrit, red blood cell (RBC) deformability and RBC aggregates strength. Our findings suggest that both the abilities to use oxygen during exercise and to recover after a physical activity are impaired in SCA patients. This poor physical fitness seems to depend on the degree of anemia and RBC rheological alterations.
authors.affiliation: Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Keyne
authors.initials: K
authors.lastname: Charlot
authors.affiliation: Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Waltz
authors.affiliation: Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|Emergency Care Department, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Mona
authors.initials: M
authors.lastname: Hedreville
authors.affiliation: Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Sinnapah
authors.affiliation: Sickle cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lemonne
authors.affiliation: Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.|Sickle cell Center, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Maryse
authors.initials: M
authors.lastname: Etienne-Julan
authors.affiliation: Direction of Research and Innovation, Academic Hospital of Pointe-à-Pitre, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Soter
authors.affiliation: Laboratory ACTES (EA 3596), Department of Physiology, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Hue
authors.affiliation: UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
authors.affiliation: UMR Inserm U1134, French West Indies and Guiana University, Pointe-à-Pitre, Guadeloupe, France.|Laboratoire d'Excellence du Globule Rouge (LABEX GR-Ex), PRES Sorbonne, Paris, France.|Institut Universitaire de France (IUF), Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
mesh_terms: D000328:Adult; D004907:Erythrocyte Deformability; D005260:Female; D018056:Hemorheology; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption / Q000502:physiology*; D010809:Physical Fitness / Q000502:physiology*
keywords: Physical activity; exercise recovery; hemorheology; physical fitness; sickle cell disease