title: MTA1 overexpression induces cisplatin resistance in nasopharyngeal carcinoma by promoting cancer stem cells properties.
abstract: Themetastasis-associated gene 1 (MTA1) oncogene hasbeen suggested to be involved in the regulation of cancer progression. However, there is still no direct evidence that MTA1 regulates cisplatin (CDDP) resistance, as well as cancer stem cell properties. In this study, we found that MTA1 was enriched in CNE1/CDDP cells. Knock down of MTA1 in CNE1/CDDP cells reversed CSCs properties and CDDP resistance. However, ectopic expression of MTA1 in CNE1 cells induced CSCs phenotypes and CDDP insensitivity. Interestingly, ectopic overexpression of MTA1-induced CSCs properties and CDDP resistance were reversed in CNE1 cells after inhibition of PI3K/Akt by LY294002. In addition, MTA1 expression and Akt activity in CNE1/CDDP cells was much higher than that in CNE1 cells. These results suggested that MTA1 may play a critical role in promoting CDDP resistance in NPC cells by regulatingcancer stem cell properties via thePI3K/Akt signaling pathway. Our findings suggested that MTA1 may be a potential target for overcoming CDDP resistance in NPC therapy.
authors.affiliation: Department of Otolaryngology, General Hospital of Guangzhou Command, Guangzhou, China ; These authors contributed equally to this work.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Feng
authors.affiliation: Cancer Institute of Southern Medical University, Guangzhou, China ; These authors contributed equally to this work.
authors.forename: Qianbing
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of stomatology, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China ; These authors contributed equally to this work.
authors.forename: Songxin
authors.initials: S
authors.lastname: Xia
authors.affiliation: Department of Cardiology, 458 Hospital of People's Liberation Army, Guangzhou, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Xia
authors.affiliation: Department of Radiotherapy, Nanfang Hospital of Southern Medical University, Guangzhou, China ; Department of Cardiology, 458 Hospital of People's Liberation Army, Guangzhou, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Radiotherapy, Nanfang Hospital of Southern Medical University, Guangzhou, China.
authors.forename: Xubin
authors.initials: X
authors.lastname: Deng
authors.affiliation: Cancer Center of Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.
authors.forename: Wenmei
authors.initials: W
authors.lastname: Su
authors.affiliation: Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University; Cancer Center of Guangzhou Medical University (CCGMU), Guangzhou, China.
authors.forename: Jianqing
authors.initials: J
authors.lastname: Huang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002277:Carcinoma; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D055785:Gene Knockdown Techniques; D006655:Histone Deacetylases / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008819:Mice, Nude; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin; D006655:Histone Deacetylases; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D012097:Repressor Proteins; D015534:Trans-Activators; C089320:MTA1 protein, human
keywords: MTA1; cancer stem cell; cisplatin-resistance; nasopharyngeal carcinoma