title: Oxidative stress in entomopathogenic fungi grown on insect-like hydrocarbons.
abstract: Entomopathogenic fungi mostly attack their insect hosts by penetration through the cuticle. The outermost insect surface is covered by a lipid-rich layer, usually composed of very long chain hydrocarbons. These fungi are apt to grow on straight chain hydrocarbons (alkanes) as the sole carbon source. Insect-like hydrocarbons are first hydroxylated by a microsomal P450 monooxygenase system, and then fully catabolized by peroxisomal β-oxidation reactions in Beauveria bassiana. In this review, we will discuss lipid metabolism adaptations in alkane-grown fungi, and how an oxidative stress scenario is established under these conditions. Fungi have to pay a high cost for hydrocarbon utilization; high levels of reactive oxygen species are produced and a concomitant antioxidant response is triggered in fungal cells to cope with this drawback.
authors.affiliation: Facultad de Ciencias Médicas, Instituto de Investigaciones Bioquímicas de La Plata (CCT La Plata CONICET-UNLP), Calles 60 y 120, La Plata, Argentina.
authors.forename: Carla
authors.initials: C
authors.lastname: Huarte-Bonnet
authors.forename: M Patricia
authors.initials: MP
authors.lastname: Juárez
authors.forename: Nicolás
authors.initials: N
authors.lastname: Pedrini
mesh_terms: D000473:Alkanes / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004734:Energy Metabolism; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006838:Hydrocarbons / Q000378:metabolism*; D007313:Insecta / Q000382:microbiology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000473:Alkanes; D000975:Antioxidants; D005656:Fungal Proteins; D006838:Hydrocarbons