title: DNA-mediated electron transfer in DNA duplexes tethered to gold electrodes via phosphorothioated dA tags.
abstract: The efficiency of DNA-based bioelectronic devices strongly depends on the way DNA molecules are linked to the electronic component. Commonly, DNA is tethered to metal electrodes via an alkanethiol linker representing an additional barrier for electron transport. Here we demonstrate that the replacement of the alkanethiol linker for a phosphorothioated adenosine tag increases the rate of DNA-mediated electron transfer (ET) up to 259 s(-1), representing the highest hitherto reported rate of electrochemically-modulated ET, and improves the stability of DNA-electrode surface binding. Both results offer pronounced technological and scientific benefits for DNA-based electronics.
authors.affiliation: Interdisciplinary Nanoscience Center (iNANO) and ‡Center for DNA Nanotechnology (CDNA) at iNANO, Science and Technology, Aarhus University , Gustav Wieds Vej 14, 8000 Aarhus, Denmark.
authors.forename: Rui
authors.initials: R
authors.lastname: Campos
authors.forename: Alexander
authors.initials: A
authors.lastname: Kotlyar
authors.forename: Elena E
authors.initials: EE
authors.lastname: Ferapontova
mesh_terms: D004247:DNA / Q000737:chemistry*; D055664:Electrochemical Techniques; D004566:Electrodes; D004579:Electron Transport; D004581:Electronics / Q000295:instrumentation*; D004583:Electrons; D006046:Gold / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D054735:Phosphorothioate Oligonucleotides / Q000138:chemical synthesis*
chemical_list: D054735:Phosphorothioate Oligonucleotides; D006046:Gold; D004247:DNA