title: Evaluation of association of maternal IL-10 polymorphisms with risk of preeclampsia by A meta-analysis.
abstract: Emerging evidence shows that interleukin (IL)-10 gene polymorphisms can regulate its expression level and thus influence person's susceptibility to preeclampsia. However, various published results were inconsistent. To explore the association between maternal IL-10 gene polymorphisms and preeclampsia, we performed a meta-analysis based upon 11 individual studies here. Our meta-analysis results indicated that IL-10 -819 C/T (C versus T, OR = 1.28, 95% CI = 1.08-1.50, P = 0.003) and -592 C/A (C versus A, OR = 1.28, 95% CI = 1.03-1.59, P = 0.03) polymorphisms were associated with preeclampsia. Although there was no overall association between -1082 A/G polymorphism and preeclampsia (G versus A, OR = 0.93, 95% CI = 0.77-1.13, P = 0.49), such association existed among Asian (G versus A, OR = 1.29, 95% CI = 1.04-1.60, P = 0.02) and South American (G versus A, OR = 0.72, 95% CI = 0.54-0.94, P = 0.02) populations in the subgroup analysis stratified by continents.
authors.affiliation: Management Department, Shanghai Medical Instrumentation College, Shanghai, China.
authors.forename: Wenchao
authors.initials: W
authors.lastname: Yang
authors.forename: Zhenmin
authors.initials: Z
authors.lastname: Zhu
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Ye
authors.forename: Yong
authors.initials: Y
authors.lastname: Ding
mesh_terms: D001208:Asia; D044466:Asian People / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D013020:South America
chemical_list: D016753:Interleukin-10
keywords: IL-10; meta-analysis; polymorphism; preeclampsia