title: An unusual case of episodic SUNCT responding to high doses of topiramate.
abstract: Trigeminal autonomic cephalalgias (TAC) are rare. Cluster headaches comprise the majority, with short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) being the rarest and shortest in duration. The majority of SUNCT are primary with a few cases occurring secondary to posterior fossa or pituitary lesions. Although activities like exercise or blowing of the nose can trigger SUNCT, onset during orgasm has not been described. Short-lasting aura has been described in TACs including SUNCT, but persistence of focal symptoms and signs without an underlying structural lesion have not been described. Lastly, treatment of SUNCT is difficult, with lamotrigine being the most common effective reported. We report a case of episodic SUNCT with symptoms suggestive of brainstem stroke that completely resolved spontaneously for which no underlying structural cause was found. The onset of first attack occurred during orgasm, and the patient responded to a high dose of topiramate.
authors.affiliation: Department of Neurology, Hull Royal Infirmary, Kingston-upon-Hull, UK.
authors.forename: Modar
authors.initials: M
authors.lastname: Khalil
authors.forename: Farooq
authors.initials: F
authors.lastname: Maniyar
authors.forename: Fayyaz
authors.initials: F
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006261:Headache / Q000150:complications; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D000077236:Topiramate; D051303:Trigeminal Autonomic Cephalalgias / Q000150:complications / Q000188:drug therapy*
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose
keywords: SUNA; SUNCT; brainstem; orgasm; topiramate; trigeminal autonomic cephalalgia