title: Sequential [(18)F]FDG µPET whole-brain imaging of central vestibular compensation: a model of deafferentation-induced brain plasticity.
abstract: Unilateral inner ear damage is followed by a rapid behavioural recovery due to central vestibular compensation. In this study, we utilized serial [(18)F]Fluoro-deoxyglucose ([(18)F]FDG)-µPET imaging in the rat to visualize changes in brain glucose metabolism during behavioural recovery after surgical and chemical unilateral labyrinthectomy, to determine the extent and time-course of the involvement of different brain regions in vestibular compensation and test previously described hypotheses of underlying mechanisms. Systematic patterns of relative changes of glucose metabolism (rCGM) were observed during vestibular compensation. A significant asymmetry of rCGM appeared in the vestibular nuclei, vestibulocerebellum, thalamus, multisensory vestibular cortex, hippocampus and amygdala in the acute phase of vestibular imbalance (4 h). This was followed by early vestibular compensation over 1-2 days where rCGM re-balanced between the vestibular nuclei, thalami and temporoparietal cortices and bilateral rCGM increase appeared in the hippocampus and amygdala. Subsequently over 2-7 days, rCGM increased in the ipsilesional spinal trigeminal nucleus and later (7-9 days) rCGM increased in the vestibulocerebellum bilaterally and the hypothalamus and persisted in the hippocampus. These systematic dynamic rCGM patterns during vestibular compensation, were confirmed in a second rat model of chemical unilateral labyrinthectomy by serial [(18)F]FDG-µPET. These findings show that deafferentation-induced plasticity after unilateral labyrinthectomy involves early mechanisms of re-balancing predominantly in the brainstem vestibular nuclei but also in thalamo-cortical and limbic areas, and indicate the contribution of spinocerebellar sensory inputs and vestibulocerebellar adaptation at the later stages of behavioural recovery.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany. andreas.zwergal@med.uni-muenchen.de.|German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany. andreas.zwergal@med.uni-muenchen.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zwergal
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Schlichtiger
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.|Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Guoming
authors.initials: G
authors.lastname: Xiong
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.|Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Roswitha
authors.initials: R
authors.lastname: Beck
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.|Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Lisa
authors.initials: L
authors.lastname: Günther
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.|German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Schniepp
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Schöberl
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.|German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Jahn
authors.affiliation: German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.|Institute for Clinical Neurosciences, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Brandt
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.|German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Strupp
authors.affiliation: Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Bartenstein
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.|German Center for Vertigo and Balance Disorders, DSGZ, Ludwig-Maximilians-University of Munich, Munich, Germany.
authors.forename: Marianne
authors.initials: M
authors.lastname: Dieterich
authors.affiliation: Center for Integrate Physiology, University of Edinburgh, Edinburgh, Scotland, UK.
authors.forename: Mayank B
authors.initials: MB
authors.lastname: Dutia
authors.affiliation: Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany.|Division of Nuclear Medicine, Department of Radiology, Eberhard-Karls-University, Tuebingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: la Fougère
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000000981:diagnostic imaging / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D008297:Male; D009473:Neuronal Plasticity; D009759:Nystagmus, Pathologic / Q000209:etiology; D049268:Positron-Emission Tomography; D011187:Posture; D051381:Rats; D017207:Rats, Sprague-Dawley; D014726:Vestibular Nuclei / Q000000981:diagnostic imaging / Q000378:metabolism*; D014722:Vestibule, Labyrinth / Q000293:injuries* / Q000294:innervation
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose
keywords: Rat; Unilateral labyrinthectomy; Vestibular compensation; µPET