title: Effects of intra-aortic balloon counterpulsation pump on mortality of acute myocardial infarction.
abstract: BACKGROUND
  Several randomized controlled trials (RCTs) have evaluated the effect of intra-aortic balloon counterpulsation pump(IABP) on the mortality of acute myocardial infarction (AMI).
  
  
  OBJECTIVE
  To analyze the relevant RCT data on the effect of IABP on mortality and the occurrence of bleeding in AMI.
  
  
  METHODS
  Published RCTs on the treatment of AMI by IABP were retrieved in searches of Medline, EMBASE, Cochrane and other related databases. The last search was conducted on July 20, 2014.
  
  
  METHODS
  Randomized clinical trials comparing IABP to controls as treatment for AMI.
  
  
  METHODS
  Patients with AMI.
  
  
  METHODS
  The primary endpoint was mortality, and the secondary endpoint was bleeding events. To account for to heterogeneity, a random-effects model was used to analyze the study data.
  
  
  RESULTS
  Ten trials with a total population of 973 patients that were included in the analysis showed no significant difference in 2-month mortality between the IABP and the control groups. The 6-month mortality in the IABP group was not significantly lower than in the control group in the four RCTs that enrolled 59 AMI patients with CS. But in the four that enrolled AMI 66 patients without CS, the data showed opposite conclusion.
  
  
  CONCLUSIONS
  IABP cannot reduce within 2 months and 6-12 months mortality of AMI patients with CS as well as within 2 months mortality of AMI patients without CS, but can reduce 6-12 months mortality of AMI patients without CS. In addition, IABP can increase the risk of bleeding.
authors.affiliation: Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Liwen
authors.initials: L
authors.lastname: Ye
authors.affiliation: Chongqing Ophthalmology Research Center for the Senile, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Ophthalmology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Minming
authors.initials: M
authors.lastname: Zheng
authors.affiliation: Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Chen
authors.affiliation: Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Guiqion
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Geriatrics Cardiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Ke
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000009:adverse effects* / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis