title: Development of an integrated surface stimulation device for systematic evaluation of wound electrotherapy.
abstract: Ideally, all chronic wounds would be prevented as they can become life threatening complications. The concept that a wound produces a 'current of injury' due to the discontinuity in the electrical field of intact skin provides the basis for the concept that electrical stimulation (ES) may provide an effective treatment for chronic wounds. The optimal stimulation waveform parameters are unknown, limiting the reliability of achieving a successful clinical therapeutic outcome. In order to gain a more thorough understanding of ES for chronic wound therapy, systematic evaluation using a valid in vivo model is required. The focus of the current paper is development of the flexible modular surface stimulation (MSS) device by our group. This device can be programed to deliver a variety of clinically relevant stimulation paradigms and is essential to facilitate systematic in vivo studies. The MSS version 2.0 for small animal use provides all components of a single-channel, programmable current-controlled ES system within a lightweight, flexible, independently-powered portable device. Benchtop testing and validation indicates that custom electronics and control algorithms support the generation of high-voltage, low duty-cycle current pulses in a power-efficient manner, extending battery life and allowing ES therapy to be delivered for up to 7 days without needing to replace or disturb the wound dressing.
authors.affiliation: Advanced Platform Technology Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Howe
authors.forename: J
authors.initials: J
authors.lastname: Dunning
authors.forename: C
authors.initials: C
authors.lastname: Zorman
authors.forename: S L
authors.initials: SL
authors.lastname: Garverick
authors.forename: K M
authors.initials: KM
authors.lastname: Bogie
mesh_terms: D011211:Electric Power Supplies; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004566:Electrodes; D014945:Wound Healing