title: Characterization of a pancreatic islet cell tumor in a polar bear (Ursus maritimus).
abstract: Herein, we report a 25-year-old male polar bear suffering from a pancreatic islet cell tumor. The aim of this report is to present a case of this rare tumor in a captive polar bear. The implication of potential risk factors such as high carbohydrate diet or the presence of amyloid fibril deposits was assessed. Necropsy examination revealed several other changes, including nodules observed in the liver, spleen, pancreas, intestine, and thyroid glands that were submitted for histopathologic analysis. Interestingly, the multiple neoplastic nodules were unrelated and included a pancreatic islet cell tumor. Immunohistochemistry of the pancreas confirmed the presence of insulin and islet amyloid polypeptide (IAPP) within the pancreatic islet cells. The IAPP gene was extracted from the paraffin-embedded liver tissue and sequenced. IAPP cDNA from the polar bear exhibits some differences as compared to the sequence published for several other species. Different factors responsible for neoplasms in bears such as diet, infectious agents, and industrial chemical exposure are reviewed. This case report raised several issues that further studies may address by evaluating the prevalence of cancers in captive or wild animals.
authors.affiliation: Département de Pathologie et Microbiologie, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Québec, Canada.
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Fortin
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Benoit-Biancamano
mesh_terms: D007516:Adenoma, Islet Cell; D000595:Amino Acid Sequence; D000818:Animals; D000836:Animals, Zoo; D001483:Base Sequence; D017809:Fatal Outcome; D006652:Histological Techniques / Q000662:veterinary; D007150:Immunohistochemistry / Q000662:veterinary; D007328:Insulin / Q000097:blood; D058228:Islet Amyloid Polypeptide / Q000235:genetics / Q000378:metabolism; D008297:Male; D008969:Molecular Sequence Data; D018358:Neuroendocrine Tumors / Q000473:pathology* / Q000662:veterinary*; D012307:Risk Factors; D017422:Sequence Analysis, DNA / Q000662:veterinary; D013045:Species Specificity; D001503:Ursidae
chemical_list: D007328:Insulin; D058228:Islet Amyloid Polypeptide
keywords: Arctic bear; insulinoma; islet amyloid polypeptide (IAPP)