title: Neuropsychology of reward learning and negative symptoms in schizophrenia.
abstract: We used the Iowa Gambling Test (IGT) to examine the relationship of reward learning to both neuropsychological functioning and symptom formation in 65 individuals with schizophrenia. Results indicated that compared to controls, participants with schizophrenia showed significantly reduced reward learning, which in turn correlated with reduced intelligence, memory and executive function, and negative symptoms. The current findings suggested that a disease-related disturbance in reward learning may underlie both cognitive and motivation deficits, as expressed by neuropsychological impairment and negative symptoms in schizophrenia.
authors.affiliation: Department of Psychology, University of Massachusetts, Boston, MA, United States; Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States. Electronic address: paul.nestor@umb.edu.
authors.forename: Paul G
authors.initials: PG
authors.lastname: Nestor
authors.affiliation: Department of Psychology, University of Massachusetts, Boston, MA, United States; Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States.
authors.forename: Victoria
authors.initials: V
authors.lastname: Choate
authors.affiliation: Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States.
authors.forename: Margaret
authors.initials: M
authors.lastname: Niznikiewicz
authors.affiliation: Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: James J
authors.initials: JJ
authors.lastname: Levitt
authors.affiliation: Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
authors.forename: Martha E
authors.initials: ME
authors.lastname: Shenton
authors.affiliation: Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, United States.
authors.forename: Robert W
authors.initials: RW
authors.lastname: McCarley
mesh_terms: D000328:Adult; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D012201:Reward; D012559:Schizophrenia / Q000150:complications / Q000503:physiopathology*
keywords: Iowa Gambling Test; Negative symptoms; Reward learning; Schizophrenia