title: Default mode network subsystem alterations in obsessive-compulsive disorder.
abstract: BACKGROUND
  Although neurobiological models of obsessive-compulsive disorder (OCD) traditionally emphasise the central role of corticostriatal brain regions, studies of default mode network integrity have garnered increasing interest, but have produced conflicting results.
  
  
  OBJECTIVE
  To resolve these discrepant findings by examining the integrity of default mode network subsystems in OCD.
  
  
  METHODS
  Comparison of seed-based resting-state functional connectivity of 11 default mode network components between 46 patients with OCD and 46 controls using functional magnetic resonance imaging.
  
  
  RESULTS
  Significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem was identified in the OCD group, and remained significant after controlling for medication status and life-time history of affective disorders. Further, greater connectivity between the self subsystem and salience and attention networks was observed.
  
  
  CONCLUSIONS
  Results indicate that people with OCD show abnormalities in a neural system previously associated with self-referential processing in healthy individuals, and suggest the need for examination of dynamic interactions between this default mode network subsystem and other large-scale networks in this disorder.
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Jan C
authors.initials: JC
authors.lastname: Beucke
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Jorge
authors.initials: J
authors.lastname: Sepulcre
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Eldaief
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Miriam
authors.initials: M
authors.lastname: Sebold
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Kathmann
authors.affiliation: Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Kaufmann
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000503:physiopathology*; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology*; D012720:Severity of Illness Index; D055815:Young Adult