title: Circulating miRNAs in ageing and ageing-related diseases.
abstract: MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. They are involved in important biological processes including development, homeostasis, and ageing. Recently, extracellular miRNAs have been discovered in the bloodstream and bodily fluids. These miRNAs are shown to be secreted and circulating in microvesicles (MVs), or in complex with other factors such as RNA-binding proteins and high-density lipoprotein (HDL) particles. These cell-free, circulating miRNAs can be taken into and function as negative regulators of target genes in recipient cells. Here we review the biogenesis and uptake of circulating miRNAs as well as their profiles in ageing and ageing-related diseases. We discuss the emerging role of circulating miRNAs as biomarkers and therapeutic targets.
authors.affiliation: Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 11363, USA.
authors.forename: Hwa Jin
authors.initials: HJ
authors.lastname: Jung
authors.affiliation: Department of Genetics and Medicine, Albert Einstein College of Medicine, Bronx, NY 11363, USA; Ageing Research Institute, Guangdong Medical College, Dongguan 523808, China. Electronic address: yousin.suh@einstein.yu.edu.
authors.forename: Yousin
authors.initials: Y
authors.lastname: Suh
mesh_terms: D000375:Aging / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D004194:Disease / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics* / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D035683:MicroRNAs
keywords: Ageing; Ageing-related disease; Biomarkers; Circulating miRNAs