title: Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.
abstract: Selenium may play a beneficial role in multi-factorial illnesses with genetic and environmental linkages via epigenetic regulation in part via glutathione peroxidase (GPx) activity. A meta-analysis was undertaken to quantify the effects of dietary selenium supplementation on the activity of overall GPx activity in different tissues and animal species and to compare the effectiveness of different forms of dietary selenium. GPx activity response was affected by both the dose and form of selenium (p < 0.001). There were differences between tissues on the effects of selenium supplementation on GPx activity (p < 0.001); however, there was no evidence in the data of differences between animal species (p = 0.95). The interactions between dose and tissue, animal species and form were significant (p < 0.001). Tissues particularly sensitive to changes in selenium supply include red blood cells, kidney and muscle. The meta-analysis identified that for animal species selenium-enriched foods were more effective than selenomethionine at increasing GPx activity.
authors.affiliation: Food Nutrition & Health, Food & Bio-based Products, AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand. emma.bermingham@agresearch.co.nz.
authors.forename: Emma N
authors.initials: EN
authors.lastname: Bermingham
authors.affiliation: Institute for Cell & Molecular Biosciences, University of Newcastle upon Tyne, Newcastle NE2 4HH, UK. j.e.hesketh@newcastle.ac.uk.
authors.forename: John E
authors.initials: JE
authors.lastname: Hesketh
authors.affiliation: Food Nutrition & Health, Food & Bio-based Products, AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand. bruce.sinclair@agresearch.co.nz.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Sinclair
authors.affiliation: Bioinformatics & Statistics AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand. john.koolaard@agresearch.co.nz.
authors.forename: John P
authors.initials: JP
authors.lastname: Koolaard
authors.affiliation: Food Nutrition & Health, Food & Bio-based Products, AgResearch Grasslands, Private Bag 11008, Tennent Drive, Palmerston North 4442, New Zealand. nicole.roy@agresearch.co.nz.
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Roy
mesh_terms: D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005527:Food, Fortified; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012645:Selenomethionine / Q000008:administration & dosage / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D012645:Selenomethionine; D005979:Glutathione Peroxidase; D012643:Selenium