title: Neolignans, lignans and glycoside from the fruits of Melia toosendan.
abstract: Four new neolignans, meliasendanins A-D (1-4), and a new glycoside, toosenoside A (5), together with ten known ones (6-15), were isolated from a n-BuOH partition of the fruits of Melia toosendan. Their structures were elucidated by analyses of extensive spectroscopic data and comparison of the NMR data with those reported previously. Meliasendanin A (1) was a rare neolignan containing isochroman moiety, and its absolute configuration was determined using a CD spectrum. Toosenoside A (5) was an unusual glycoside with a rare naturally occurring aglycone and its structure was confirmed by X-ray single crystal diffraction analysis. The antioxidant activity of the isolated neolignans and lignans was evaluated by ABTS radical-scavenging assay. Compounds 1 and 13 exhibited strong antioxidant activity, with IC₅₀ values of 62.8 and 45.1 μM, respectively.
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Lun
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
authors.forename: Fu
authors.initials: F
authors.lastname: Li
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar 25120, Pakistan.
authors.forename: Ashfaq-Ahmad
authors.initials: AA
authors.lastname: Khan
authors.affiliation: Beijing Entry-Exit Inspection and Quarantine Bureau, Beijing 100026, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. Electronic address: wangmk@cib.ac.cn.
authors.forename: Ming-Kui
authors.initials: MK
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D005638:Fruit / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D031585:Melia / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D006027:Glycosides; D017705:Lignans; C000597657:toosenoside A
keywords: Antioxidant activity; Glycoside; Lignans; Melia toosendan; Meliaceae; Neolignans