title: A case of fatal late vasospasm in a patient with a recurrent, supratentorial rhabdoid primitive neuroectodermal tumor: possible molecular implications.
abstract: We report the case of a 44-year-old man who experienced a fatal and untreatable delayed vasospasm after resection of a recurrent temporal IV grade primitive neuroectodermal tumor (PNET). The histological analysis demonstrated a rare rhabdoid variant of the tumor with a diffuse myxoid degeneration; molecular investigations demonstrated an upregulation of IL-1β and IL-6 expression in the recurrence. We reviewed the pathophysiology of the vasospasm that occurs after tumors resection, and due to the rarity of case, we speculated on the possibility that specific histological and molecular features of the tumor could have contributed to the delayed and fatal complication.
authors.affiliation: Sapienza University of Rome, Medico-Surgical Sciences and Biotechnologies, Latina, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Miscusi
authors.forename: Luca De
authors.initials: LD
authors.lastname: Martino
authors.forename: Manila
authors.initials: M
authors.lastname: Antonelli
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mangino
authors.forename: Luca
authors.initials: L
authors.lastname: Ricciardi
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Spinelli
authors.forename: Stefano
authors.initials: S
authors.lastname: Forcato
authors.forename: Antonella
authors.initials: A
authors.lastname: Calogero
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Petrozza
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ragona
authors.forename: Antonino
authors.initials: A
authors.lastname: Raco
mesh_terms: D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D053583:Interleukin-1beta / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D018242:Neuroectodermal Tumors, Primitive / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D015173:Supratentorial Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D020301:Vasospasm, Intracranial / Q000175:diagnosis* / Q000209:etiology
chemical_list: D053583:Interleukin-1beta; D012333:RNA, Messenger