title: Function and size of the residual kidney after treatment of Wilms tumor.
abstract: Long-term damage to the residual kidney is of concern in the survivors of Wilms tumor. Our objective was to evaluate the long-term glomerular function and size of the residual kidney in these patients. Twenty-nine survivors of Wilms tumor diagnosed between July 1999 and June 2004 were enrolled. The glomerular function was assessed by creatinine clearance, 99mTc DTPA radionuclide scintigraphy and 24-hour urinary protein. Renal size was evaluated by ultrasonography. Median age at diagnosis and at enrollment were 2.87 ± 1.8 (range: 0.5-7.5) and 7.9 ± 3.8 years (range: 2.5-18). Median duration of follow-up was 4.78 ± 2.6 years (range: 1-8.8). Evidence of renal dysfunction in the form of either function or size was identified in eight (27.6%) children. Six children had subnormal glomerular filtration rate and one had proteinuria. Subnormal size of the residual kidney was observed in one child. Age at diagnosis, stage, and duration elapsed after nephrectomy had no association with renal dysfunction (P >.05). Long-term follow up is crucial to identify clinical nephrotoxicity among survivors of Wilms tumor.
authors.affiliation: Division of Pediatric Hematology Oncology, Department of Pediatrics, Advanced Pediatric Centre , Chandigarh , India.
authors.forename: Sai Sunil
authors.initials: SS
authors.lastname: Kishore
authors.forename: Sapna
authors.initials: S
authors.lastname: Oberoi
authors.forename: Anish
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Rajender
authors.initials: R
authors.lastname: Prasad
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.forename: Deepak
authors.initials: D
authors.lastname: Bansal
authors.forename: Ram Kumar
authors.initials: RK
authors.lastname: Marwaha
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007668:Kidney / Q000503:physiopathology*; D012189:Retrospective Studies; D009396:Wilms Tumor / Q000503:physiopathology / Q000601:surgery
keywords: India; Wilms; children; nephrotoxicity