title: Campylobacter, Salmonella, and Yersinia antibodies and pregnancy outcome in Danish women with occupational exposure to animals.
abstract: BACKGROUND
  The aim of this study was to determine antibody titres against Campylobacter, Salmonella, and Yersinia in a population-based cohort of pregnant women in Denmark in order to evaluate adverse pregnancy outcomes (miscarriage, preterm birth, and small for gestational age) in relation to occupational exposure to animals in women exposed to food producing animals.
  
  
  METHODS
  We used data and blood samples from the Danish National Birth Cohort. Serum samples collected during the first trimester from 192 pregnant women who were occupationally exposed to domestic animals and 188 randomly selected unexposed pregnant women were analysed for IgG, IgM, and IgA antibodies against Campylobacter, Salmonella, and Yersinia. Pregnancy outcomes of interest were identified through the Danish National Patient Register.
  
  
  RESULTS
  Women with occupational exposure to animals had significantly higher IgG antibody concentrations against Campylobacter, Salmonella, and Yersinia, whereas they had lower concentrations of IgM and IgA antibodies.
  
  
  CONCLUSIONS
  Serological markers were not identified as risk factors for adverse pregnancy outcomes, with the exception of elevated concentrations of Salmonella antibodies, which were found to be associated with an increased risk of preterm birth.
authors.affiliation: Microbiological Diagnostics and Virology, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen, Denmark. Electronic address: bjk@ssi.dk.
authors.forename: Bjørn
authors.initials: B
authors.lastname: Kantsø
authors.affiliation: Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anne-Marie Nybo
authors.initials: AM
authors.lastname: Andersen
authors.affiliation: Infectious Disease Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Kåre
authors.initials: K
authors.lastname: Mølbak
authors.affiliation: Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark.
authors.forename: Karen Angeliki
authors.initials: KA
authors.lastname: Krogfelt
authors.affiliation: Perinatal Epidemiology Research Unit and Department of Paediatrics, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Tine Brink
authors.initials: TB
authors.lastname: Henriksen
authors.affiliation: Department of Occupational Medicine, Regional Hospital West Jutland, Herning, Denmark; Department of Clinical Microbiology, Aarhus University Hospital, Skejby, Denmark.
authors.forename: Stine Yde
authors.initials: SY
authors.lastname: Nielsen
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000818:Animals; D000829:Animals, Domestic; D000907:Antibodies, Bacterial / Q000097:blood*; D001724:Birth Weight; D002167:Campylobacter / Q000276:immunology*; D003718:Denmark; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016273:Occupational Exposure / Q000009:adverse effects*; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012307:Risk Factors; D012475:Salmonella / Q000276:immunology*; D015007:Yersinia / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial
keywords: Campylobacter; Miscarriage; Preterm birth; Salmonella; Small for gestational age (SGA); Yersinia