title: Vitamin B1 deficiency inhibits the increased conversion of tryptophan to nicotinamide in severe food-restricted rats.
abstract: The conversion of tryptophan (Trp) → nicotinamide (Nam) is an important pathway for supplying vitamin niacin. We reported the following two phenomena: (1) severe food restriction led to an increase in the Trp → Nam conversion compared with free-access control group; (2) the conversion of Trp → Nam is also increased by vitamin B1 deficiency compared with free-access control group. The present study was done to clarify whether or not a true reason about an increase in the Trp → Nam conversion is a vitamin B1 deficiency or severe food restriction. The present results showed that vitamin B1 deficiency suppressed the increased conversion of Trp → Nam induced by severe food restriction, probably by suppressing 3-hydroxyanthranilic acid 3,4-dioxygenase protein synthesis in liver.
authors.affiliation: a Department of Nutrition, School of Human Cultures , The University of Shiga Prefecture , Hikone , Japan.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Shibata
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Fukuwatari
mesh_terms: D050561:3-Hydroxyanthranilate 3,4-Dioxygenase / Q000096:biosynthesis; D015095:3-Hydroxyanthranilic Acid / Q000378:metabolism; D000818:Animals; D005508:Food Deprivation; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009525:Niacin / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism*; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013831:Thiamine / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014804:Vitamin B Deficiency / Q000378:metabolism* / Q000473:pathology
chemical_list: D015095:3-Hydroxyanthranilic Acid; D009536:Niacinamide; D009525:Niacin; D014364:Tryptophan; D050561:3-Hydroxyanthranilate 3,4-Dioxygenase; D013831:Thiamine
keywords: food restriction; nicotinamide; rat; tryptophan; vitamin B1