title: The role of 8-oxoguanine DNA glycosylase-1 in inflammation.
abstract: Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine's lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1-BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1-BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. baxq755@nenu.edu.cn.
authors.forename: Xueqing
authors.initials: X
authors.lastname: Ba
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. leaguile@utmb.edu.
authors.forename: Leopoldo
authors.initials: L
authors.lastname: Aguilera-Aguirre
authors.affiliation: Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA. qnrashid@utmb.edu.
authors.forename: Qura Tul Ain Nmi
authors.initials: QT
authors.lastname: Rashid
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. bacsi.attila@gmail.com.
authors.forename: Attila
authors.initials: A
authors.lastname: Bacsi
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. radak@mail.hupe.hu.
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Radak
authors.affiliation: Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA. sasur@utmb.edu.
authors.forename: Sanjiv
authors.initials: S
authors.lastname: Sur
authors.affiliation: Departments of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA. kohosoki@utmb.edu.
authors.forename: Koa
authors.initials: K
authors.lastname: Hosoki
authors.affiliation: Radiation Oncology and Neurology, Houston Methodist Research Institute, Houston, TX 77030, USA. mlhegde@HoustonMethodist.org.
authors.forename: Muralidhar L
authors.initials: ML
authors.lastname: Hegde
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA. sboldogh@utmb.edu.
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000737:chemistry; D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D004249:DNA Damage; D045647:DNA Glycosylases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D004785:Environmental Pollutants / Q000633:toxicity; D004789:Enzyme Activation; D004847:Epithelial Cells / Q000201:enzymology / Q000473:pathology; D020558:GTP Phosphohydrolases / Q000378:metabolism; D005786:Gene Expression Regulation; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008171:Lung Diseases / Q000201:enzymology / Q000209:etiology / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D016296:Mutagenesis; D018384:Oxidative Stress; D034622:RNA Interference; D017382:Reactive Oxygen Species / Q000378:metabolism; D012137:Respiratory System / Q000201:enzymology / Q000473:pathology
chemical_list: D016207:Cytokines; D004785:Environmental Pollutants; D017382:Reactive Oxygen Species; C024829:8-hydroxyguanine; D006147:Guanine; D045647:DNA Glycosylases; C485990:Ogg1 protein, mouse; C479058:oxoguanine glycosylase 1, human; D020558:GTP Phosphohydrolases