title: Screening for gonorrhea and Chlamydia: a systematic review for the U.S. Preventive Services Task Force.
abstract: BACKGROUND
  Previous research has supported screening for gonorrhea and chlamydia in asymptomatic, sexually active women (including pregnant women) who are younger than 25 years or at increased risk but not in other patient populations.
  
  
  OBJECTIVE
  To update the 2005 and 2007 systematic reviews for the U.S. Preventive Services Task Force on screening for gonorrhea and chlamydia in men and women, including pregnant women and adolescents.
  
  
  METHODS
  MEDLINE (1 January 2004 to 13 June 2014), Cochrane databases (May 2014), ClinicalTrials.gov, and reference lists.
  
  
  METHODS
  English-language trials and observational studies about screening effectiveness, test accuracy, and screening harms.
  
  
  METHODS
  Extracted study data were confirmed by a second investigator, and study quality and applicability were dual-rated using prespecified criteria.
  
  
  RESULTS
  Screening a subset of asymptomatic young women for chlamydia in a good-quality trial did not significantly reduce the incidence of pelvic inflammatory disease over the following year (relative risk, 0.39 [95% CI, 0.14 to 1.08]); however, 1 previous trial reported a reduction. An observational study evaluating a risk prediction tool to identify persons with chlamydia in high-risk populations had low predictive ability and applicability. In 10 new studies of asymptomatic patients, nucleic acid amplification tests demonstrated sensitivity of 86% or greater and specificity of 97% or greater for diagnosing gonorrhea and chlamydia, regardless of specimen type or test.
  
  
  CONCLUSIONS
  There were few relevant studies of screening benefits and harms. Only screening tests and methods cleared by the U.S. Food and Drug Administration for current clinical practice were included to determine diagnostic accuracy.
  
  
  CONCLUSIONS
  Chlamydia screening in young women may reduce the incidence of pelvic inflammatory disease. Nucleic acid amplification tests are accurate for diagnosing gonorrhea and chlamydia in asymptomatic persons.
  
  
  BACKGROUND
  Agency for Healthcare Research and Quality.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Zakher
authors.forename: Amy G
authors.initials: AG
authors.lastname: Cantor
authors.forename: Miranda
authors.initials: M
authors.lastname: Pappas
authors.forename: Monica
authors.initials: M
authors.lastname: Daeges
authors.forename: Heidi D
authors.initials: HD
authors.lastname: Nelson
mesh_terms: D058070:Asymptomatic Diseases; D001431:Bacteriological Techniques; D002690:Chlamydia Infections / Q000175:diagnosis* / Q000517:prevention & control; D005260:Female; D006069:Gonorrhea / Q000175:diagnosis* / Q000517:prevention & control; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000009:adverse effects; D021141:Nucleic Acid Amplification Techniques; D012307:Risk Factors