title: [Significance of positive surgical margin in radical prostatectomy].
abstract: The optimal oncological result of radical prostatectomy (RP) is complete removal of the prostate gland and seminal vesicles with negative surgical margins. Preoperative diagnostic biopsies are examined and reported by the pathologist according to standardized rules. Staging of the disease is based on modern preoperative image analysis, most commonly multiparametric MRI. Pathological assessment and reporting of RP specimens is based on the International Society of Uropathology guidelines issued by the 2009 Consensus Conference. Positive surgical margin (PSM) is reported by the pathologist in approximately 1/3rd of RP cases. PSM increases the risk of biochemical, local and systemic progression. Pseudo-whole mount assessment of these specimens is the basis for radio-pathological correlation, thus providing quality control for preoperative MRI as well as assisting preoperative image analysis, sampling and diagnostic workup.
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Lilla
authors.initials: L
authors.lastname: Madaras
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Szirtes
authors.affiliation: Radiológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Pál
authors.initials: P
authors.lastname: Bata
authors.affiliation: Urológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Riesz
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Aron
authors.initials: A
authors.lastname: Somorácz
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Eszter
authors.initials: E
authors.lastname: Székely
authors.affiliation: Urológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Miklós
authors.initials: M
authors.lastname: Romics
authors.affiliation: Urológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Majoros
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Katalin
authors.initials: K
authors.lastname: Borka
authors.affiliation: II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary. madaras.lilla@med.semmelweis-univ.hu.
authors.forename: Marcell A
authors.initials: MA
authors.lastname: Szász
authors.affiliation: Urológiai Klinika, Semmelweis Egyetem, Budapest, Hungary.
authors.forename: Péter
authors.initials: P
authors.lastname: Nyirády
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000592:standards; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen