title: The Chinese Verbal Learning Test specifically assesses hippocampal state.
abstract: BACKGROUND
  Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to determine whether memory consolidation as measured by the ChVLT was specifically associated with hippocampal volume in patients with cognitive impairment.
  
  
  METHODS
  We administered the ChVLT to 22 Chinese-speaking patients with mild cognitive impairment and 9 patients with dementia and obtained hippocampal and cortical volumes from T1-weighted magnetic resonance imaging.
  
  
  RESULTS
  Linear regression revealed that hippocampal volume explained 9.9% of the variance in delayed memory (P = .018) after controlling for the effects of age, education, immediate recall after the last learning trial, overall level of cognitive impairment, and volumes of other cortical regions.
  
  
  CONCLUSIONS
  These results indicate that the ChVLT is specifically correlated with hippocampal volume, supporting its utility for detecting hippocampal disease and monitoring hippocampal state over time.
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA rtsai@memory.ucsf.edu.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Tsai
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Josiah K
authors.initials: JK
authors.lastname: Leong
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Shubir
authors.initials: S
authors.lastname: Dutt
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital-Kaoshiung Medical Center and Chang Gung University College of Medicine, Kaoshiung, Taiwan.
authors.forename: Chiung Chih
authors.initials: CC
authors.lastname: Chang
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Allen K
authors.initials: AK
authors.lastname: Lee
authors.affiliation: Department of Neurology, VA Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Steven Z
authors.initials: SZ
authors.lastname: Chao
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Yokoyama
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Marian
authors.initials: M
authors.lastname: Tse
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.affiliation: Department of Neurology, University of California San Francisco, San Francisco, CA, USA UCSF Memory and Aging Center, San Francisco, CA, USA.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Rosen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001213:Asian / Q000208:ethnology; D002681:China / Q000208:ethnology; D060825:Cognitive Dysfunction / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D003704:Dementia / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D061212:Memory, Episodic; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000592:standards*; D014706:Verbal Learning / Q000502:physiology*
keywords: Alzheimer’s disease; Chinese; hippocampus; memory; mild cognitive impairment