title: Drug resistance-related microRNAs in hematological malignancies: translating basic evidence into therapeutic strategies.
abstract: Systemic chemotherapy has been used as the first-line therapy for patients with hematological malignancies. Despite the enormous progress in anti-tumor efficacy achieved during the last decades, the development of multidrug resistance (MDR) remains a major challenge in the successful treatment of hematological malignancies. Extensive investigations have discovered diverse mechanisms underlying MDR. More recently, increasing evidence demonstrates that miRNAs play a key regulatory role in MDR in hematological malignancies through modulating drug transporter-related proteins, cell cycle-related proteins, drug targets, autophagy, tumor microenvironment, cell survival signaling and apoptosis pathways. Pre-clinical evidence suggests that miRNAs may prove to be an ideal biomarker for predicting drug response or clinical outcomes, thus holding much promise for the development of targeted therapies and personalized medicines for the treatment of hematological malignancies. This review focuses on molecular mechanisms underlying miRNA-mediated chemoresistance in hematological malignancies and discusses evidence of transitional research aiming to bring drug resistance-associated miRNAs into clinical settings.
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China; Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Xie
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China.
authors.forename: Rongrong
authors.initials: R
authors.lastname: Jing
authors.affiliation: Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Hematology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China.
authors.forename: Zenghua
authors.initials: Z
authors.lastname: Lin
authors.affiliation: Laboratory Medicine Center, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China; Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, JS, PR China; Public Health School of Nantong University, Nantong 226001, JS, PR China. Electronic address: jsq814@hotmail.com.
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Ju
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics; D057170:Translational Research, Biomedical; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D018797:Cell Cycle Proteins; D026901:Membrane Transport Proteins; D035683:MicroRNAs; D022661:RNA, Untranslated
keywords: Biomarkers; Hematological malignancies; MicroRNAs; Multidrug resistance; Therapeutic targets; miRNAs