title: ABO and Rhesus blood groups and risk of endometriosis in a French Caucasian population of 633 patients living in the same geographic area.
abstract: OBJECTIVE
  The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis.
  
  
  METHODS
  We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses.
  
  
  RESULTS
  We observed a higher proportion of Rh-negative women in the study group, as compared to healthy controls. Multivariate analysis showed that Rh-negative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20-2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages.
  
  
  CONCLUSIONS
  Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes.
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France ; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), 75014 Paris, France ; Inserm, U1016, 75014 Paris, France.
authors.forename: Bruno
authors.identifier: 0000-0002-6385-5829
authors.initials: B
authors.lastname: Borghese
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Chartier
authors.affiliation: Serviço de Ginecologia e Obstetrícia (SGO), Hospital de Clinicas de Porto Alegre (HCPA), 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Carlos
authors.initials: C
authors.lastname: Souza
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France ; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), 75014 Paris, France ; Inserm, U1016, 75014 Paris, France.
authors.forename: Pietro
authors.initials: P
authors.lastname: Santulli
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lafay-Pillet
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: de Ziegler
authors.affiliation: Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France ; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), 75014 Paris, France ; Inserm, U1016, 75014 Paris, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D012204:Rh-Hr Blood-Group System; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D000017:ABO Blood-Group System; D012204:Rh-Hr Blood-Group System