title: Duodenal jejunal bypass attenuates non-alcoholic fatty liver disease in western diet-obese rats.
abstract: OBJECTIVE
  To evaluate the effects of duodenal-jejunal bypass (DJB) on serum and hepatic profiles of obese rats fed on a western diet (WD).
  
  
  METHODS
  Twenty eight male Wistar rats were fed a standard rodent chow diet (CTL group) or WD ad libitum. After 10 weeks, WD rats were submitted to sham (WD SHAM) or duodenal-jejunal bypass (WD DJB). Body weight, fat pad depots, glycemia, insulinemia, HOMA-IR, TyG, lipids profile and hepatic analyses were evaluated two months after surgery.
  
  
  RESULTS
  The WD SHAM group presented greater obesity, hyperglycemia, hyperinsulinemia, insulin resistance, hypertriglyceridemia and hepatic steatosis than the CTL group. WD DJB rats presented decreased serum glucose and insulin resistance, when compared to WD SHAM animals, without changes in insulinemia. In addition, DJB surgery normalized serum TG and attenuated TG accumulation and steatosis in the liver of the WD DJB group. Hepatic ACC and FAS protein expressions were similar in all groups.
  
  
  CONCLUSIONS
  Duodenal-jejunal bypass attenuates hepatic parameters of non-alcoholic fatty liver disease in obese rats fed on a western diet.
authors.affiliation: State University of Western Parana, Cascavel, PR, Brasil.
authors.forename: Claudia Emanuelli
authors.initials: CE
authors.lastname: Ebertz
authors.affiliation: Center for Biological Sciences and Health, UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Maria Lúcia
authors.initials: ML
authors.lastname: Bonfleur
authors.affiliation: UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Iala Milene
authors.initials: IM
authors.lastname: Bertasso
authors.affiliation: UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Mariana Carla
authors.initials: MC
authors.lastname: Mendes
authors.affiliation: UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Camila
authors.initials: C
authors.lastname: Lubaczeuski
authors.affiliation: Center of Medical and Pharmaceutical Sciences, UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Allan Cezar de Freitas
authors.initials: AC
authors.lastname: Araujo
authors.affiliation: Department of Physiological Sciences, Federal University of Maranhão, São Luis, MA, Brazil.
authors.forename: Antônio Marcus
authors.initials: AM
authors.lastname: Paes
authors.affiliation: Center for Biological Sciences and Health, UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Elaine Manoela Porto
authors.initials: EM
authors.lastname: de Amorim
authors.affiliation: Center for Biological Sciences and Health, UNIOESTE, Cascavel, PR, Brasil.
authors.forename: Sandra Lucinei
authors.initials: SL
authors.lastname: Balbo
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000032:analysis; D000273:Adipose Tissue; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D066273:Diet, Western; D004386:Duodenum / Q000601:surgery*; D015390:Gastric Bypass / Q000379:methods*; D007333:Insulin Resistance; D007583:Jejunum / Q000601:surgery*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D009765:Obesity / Q000378:metabolism / Q000601:surgery*; D017346:Protein Serine-Threonine Kinases / Q000032:analysis; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D014280:Triglycerides; C550470:FAST protein, mouse; D017346:Protein Serine-Threonine Kinases; C000588423:ACACA protein, human; D000103:Acetyl-CoA Carboxylase