title: Locust bean gum in the development of sustained release mucoadhesive macromolecules of aceclofenac.
abstract: The study shows the development and optimization of locust bean gum (LBG)-alginate mucoadhesive macromolecules containing aceclofenac through ionotropic-gelation using 3(2) factorial design. The effect of amount of LBG and sodium alginate on drug entrapment efficiency (%DEE), % mucoadhesion at 8h (M8) and % in vitro drug release at 10h (%Q10h) were optimized. The percentage yield, average size and DEE of macromolecules were found within the range of 93.19 to 96.65%, 1.328 ± 0.11 to 1.428 ± 0.13 μm, and 56.37 to 68.54%, respectively. The macromolecules were also characterized by SEM, FTIR and DSC. The in vitro drug release from these macromolecules (84.95 ± 2.02 to 95.33 ± 1.56% at 10h) exhibited sustained release (first-order) pattern with super case-II transport mechanism. The swelling and mucoadhesivity of these macromolecules were affected by pH of the medium. The design established the role of derived polynomial equations and plots in predicting the values of dependent variables for the preparation and optimization.
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Saily-Silvassa Road, Saily, Silvassa 396230, U.T. of Dadra and Nagar Haveli, India. Electronic address: vippra2000@yahoo.com.
authors.forename: Vipul D
authors.initials: VD
authors.lastname: Prajapati
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Saily-Silvassa Road, Saily, Silvassa 396230, U.T. of Dadra and Nagar Haveli, India.
authors.forename: Girish K
authors.initials: GK
authors.lastname: Jani
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Saily-Silvassa Road, Saily, Silvassa 396230, U.T. of Dadra and Nagar Haveli, India.
authors.forename: Naresh G
authors.initials: NG
authors.lastname: Moradiya
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Saily-Silvassa Road, Saily, Silvassa 396230, U.T. of Dadra and Nagar Haveli, India.
authors.forename: Narayan P
authors.initials: NP
authors.lastname: Randeria
authors.affiliation: Department of Pharmaceutics, S.S.R. College of Pharmacy, Saily-Silvassa Road, Saily, Silvassa 396230, U.T. of Dadra and Nagar Haveli, India.
authors.forename: Pankaj M
authors.initials: PM
authors.lastname: Maheriya
authors.affiliation: Department of Pharmaceutics, Rofel Shri G. M. Bilakhia College of Pharmacy, Namdha Campus, Namdha Road, Vapi 396191, Gujarat, India.
authors.forename: Bhanu J
authors.initials: BJ
authors.lastname: Nagar
mesh_terms: D000268:Adhesiveness; D000464:Alginates / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004337:Drug Carriers / Q000737:chemistry*; D005685:Galactans / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008351:Mannans / Q000737:chemistry*; D053149:Plant Gums / Q000737:chemistry*
chemical_list: D000464:Alginates; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005685:Galactans; D006603:Hexuronic Acids; D008351:Mannans; D053149:Plant Gums; D004008:Diclofenac; D020723:Glucuronic Acid; C056498:aceclofenac; C017471:locust bean gum
keywords: Aceclofenac; Locust bean gum; Mucoadhesive macromolecules; Sodium alginate