title: Regioselective ruthenium catalysed H-D exchange using D2O as the deuterium source.
abstract: An efficient and convenient ruthenium catalysed method for a regiospecific H/D exchange using D2O is described. Organic moieties such as pyridine, oxazole, imidazole, pyrazole, ester, ketone and carboxylic acid have been found effective directing groups in this transformation. In addition, the deuteration of the enantiopure (S)-Ketoprofen leads to the incorporation of three deuterium atoms with retention of molecular chirality.
authors.affiliation: EaStCHEM School of Chemistry, University of St Andrews, St Andrews, KY16 9ST, UK. snolan@st-andrews.ac.uk.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Piola
authors.forename: José A
authors.initials: JA
authors.lastname: Fernández-Salas
authors.forename: Simone
authors.initials: S
authors.lastname: Manzini
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan