title: Synthesis and antiviral activities of some 2,4,6-trisubstituted 1,3,5-triazines.
abstract: We describe the synthesis and results of biological evaluation of newly designed 2,4,6-trisubstituted symmetrical 1,3,5-triazine (TAZ) derivatives. Among the tested trisubstituted TAZ derivatives, some CS-symmetrical alkoxy-amino-substituted TAZ derivatives, including 7ggp and 6dpp, showed significant antiviral activity against herpes simplex virus type 1 (HSV-1). The compound with the highest level of antiviral activity was C3-symmetrical trialkoxy-TAZ derivative 4bbb, which showed a considerably high selectivity index (IC50/EC50=256.6). The structure-activity relationships for anti-HSV-1 activity of the tested 2,4,6-trisubstituted TAZ derivatives are also described.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Mibu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Airi
authors.initials: A
authors.lastname: Koga
authors.forename: Miyuki
authors.initials: M
authors.lastname: Honda
authors.forename: Kou
authors.initials: K
authors.lastname: Mizokami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujii
authors.forename: Norimasa
authors.initials: N
authors.lastname: Ota
authors.forename: Ai
authors.initials: A
authors.lastname: Yuzuriha
authors.forename: Kanji
authors.initials: K
authors.lastname: Ishimaru
authors.forename: Jianrong
authors.initials: J
authors.lastname: Zhou
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyata
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D013329:Structure-Activity Relationship; D014227:Triazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000998:Antiviral Agents; D014227:Triazines; C019309:cyanuric chloride