title: [Adverse effects of nanomaterials on biological defense mechanisms].
abstract: Nanomaterials are defined as substances that have at least one dimension <100 nm. They have unique physicochemical properties and innovative functions compared with conventional materials of submicron size. As such, they have many applications in nanomedicine, such as in drug delivery or diagnostic and imaging systems. However, there are a number of safety concerns regarding the use of nanomaterials. Therefore it is essential not only to obtain more information about nanomaterials to ensure their safety, but also to identify novel biomarkers that may predict adverse biological effects induced by nanomaterials. In this regard, neutrophil activation is thought to be involved in some biological responses that are induced after exposure to nanomaterials. However, the detailed mechanisms involved in these events are poorly understood. Here, we examine neutrophil activation induced by nanomaterials. In addition, to develop a safe and effective form of a nanomaterial, we attempted to develop potential biomarkers of silica nanoparticles by proteomics analysis. We believe that our data could provide information of value in nanomaterial risk management and in the establishment of guidelines for assessment of their use.
authors.affiliation: Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University.
authors.forename: Kazuma
authors.initials: K
authors.lastname: Higashisaka
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis; D006801:Humans; D049329:Nanostructures / Q000009:adverse effects*; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology
chemical_list: D015415:Biomarkers