title: Arthroscopic fixation of cell free polymer-based cartilage implants with a bioinspired polymer surface on the hip joint: a cadaveric pilot study.
abstract: This study investigates the adhesion capacity of a polyglycolic acid- (PGA-) hyaluronan scaffold with a structural modification based on a planar polymer (PM) surface in a cadaver cartilage defect model. Two cadaver specimens were used to serially test multiple chondral matrices. In a cadaver hip model, cell free polymer-based cartilage implants with a planar bioinspired PM surface (PGA-PM-scaffolds) were implanted arthroscopically on 10 mm × 15 mm full-thickness femoral hip cartilage lesions. Unprocessed cartilage implants without a bioinspired PM surface were used as control group. The cartilage implants were fixed without and with the use of fibrin glue on femoral hip cartilage defects. After 50 movement cycles and removal of the distraction, a rearthroscopy was performed to assess the outline attachment and integrity of the scaffold. The fixation techniques without and with fibrin fixation showed marginal differences for outline attachment, area coverage, scaffold integrity, and endpoint fixation after 50 cycles. The PGA-PM-scaffolds with fibrin fixation achieved a higher score in terms of the attachment, integrity, and endpoint fixation than the PGA-scaffold on the cartilage defect. Relating to the outline attachment, area coverage, scaffold integrity, and endpoint fixation, the fixation with PGA-PM-scaffolds accomplished significantly better results compared to the PGA-scaffolds (P = 0.03752, P = 0.03078, P = 0.00512, P = 0.00512). PGA-PM-scaffolds demonstrate increased observed initial fixation strength in cadaver femoral head defects relative to PGA-scaffold, particularly when fibrin glue is used for fixation.
authors.affiliation: Department of Orthopaedic Sports Surgery, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstrße 56, 44791 Bochum, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Lahner
authors.affiliation: Department of Orthopaedic Sports Surgery, Ruhr-University Bochum, St. Josef-Hospital, Gudrunstrße 56, 44791 Bochum, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Duif
authors.affiliation: Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital of Munich (LMU), Campus Großhadern, Marchioninistraße 15, 81377 München, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Ficklscherer
authors.affiliation: BioTissue Technologies GmbH, Charitéplatz 1, 10117 Berlin, Germany ; Tissue Engineering Laboratory, Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Kaps
authors.affiliation: Westphalian Institute for Biomimetics, Westphalian University of Applied Sciences, Münsterstraße 265, 46397 Bocholt, Germany.
authors.forename: Lukas
authors.initials: L
authors.lastname: Kalwa
authors.affiliation: Westphalian Institute for Biomimetics, Westphalian University of Applied Sciences, Münsterstraße 265, 46397 Bocholt, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Seidl
mesh_terms: D020341:Absorbable Implants; D001182:Arthroscopy; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002102:Cadaver; D002356:Cartilage / Q000293:injuries* / Q000473:pathology / Q000601:surgery*; D002474:Cell-Free System; D019544:Equipment Failure Analysis; D025981:Hip Injuries / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D008422:Materials Testing; D010865:Pilot Projects; D011100:Polyglycolic Acid / Q000737:chemistry*; D011474:Prosthesis Design; D019919:Prosthesis Implantation / Q000379:methods; D013499:Surface Properties; D054457:Tissue Scaffolds
chemical_list: D011100:Polyglycolic Acid; D006820:Hyaluronic Acid