title: Increased risk of obesity related to total energy intake with the APOA5-1131T > C polymorphism in Korean premenopausal women.
abstract: We hypothesized that triglyceride-raising apolipoprotein A5 (APOA5)-1131T > C may contribute to the increased risk of obesity associated with dietary intake in Korean premenopausal women whose minor allele frequency is higher than that in Western people. Genetically unrelated Korean premenopausal women (approximately 20-59 years, n = 1128) were genotyped for APOA5-1131T > C. Anthropometric, metabolic parameters and dietary intakes were analyzed. Odds ratios (ORs) for obesity risk (body mass index, ≥25.0 kg/m(2)) were calculated. Genotype distribution of APOA5-1131T > C of study subjects were like TT: 49.9%, TC: 40.8%, and CC: 9.3%. We found a significant interaction between APOA5-1131T > C and total energy intake (TEI) for obesity after adjusted for age, cigarette smoking, and alcohol consumption (P < .001). The risk of obesity in CC homozygotes compared with T carriers (TT + TC) was significantly increased, when the subjects consume higher TEI (≥2001 kcal/d (8372 kJ/d), median value of the population) (OR, 2.495; 95% confidence intervals, 1.325-4.696; P = .005), particularly, when they maintain negative balance between total energy expenditure and TEI (total energy expenditure/TEI, <1) (OR, 2.917; 95% confidence intervals, 1.451-5.864; P = .003). The contributions of APOA5-1131CC homozygotes to obesity risk in those who consume higher TEI were all significantly high regardless of percentage of energy intake from dietary macronutrients. Whereas, no significant association was observed in those who consume lower TEI (<2001 kcal/d). In addition, serum levels of triglyceride, high-density lipoprotein-cholesterol, and apolipoprotein A5 were associated with APOA5-1131T > C and TEI. These findings suggest that APOA5-1131CC homozygotes may influence the susceptibility of the individual to obesity, particularly, when they consume higher TEI, but the genetic effect may be attenuated, when people maintain low or adequate energy intake.
authors.affiliation: Department of Food Science Nutrition, Dong-A University, Brain Busan 21 project, Busan, Korea; Korea Centers for Disease Control & Prevention, Korea National Institute of Health, Cheongwon-gun, Chungbuk, Korea.
authors.forename: Hyo Hee
authors.initials: HH
authors.lastname: Lim
authors.affiliation: Department of Food Science Nutrition, Dong-A University, Brain Busan 21 project, Busan, Korea.
authors.forename: Miok
authors.initials: M
authors.lastname: Choi
authors.affiliation: Department of Culinary Nutrition, Woosong University, Daejun, 300-718, Republic of Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Food and Nutrition, Yonsei University, Seoul, Korea. Electronic address: jhleeb@yonsei.ac.kr.
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Food Science Nutrition, Dong-A University, Brain Busan 21 project, Busan, Korea. Electronic address: oykim@dau.ac.kr.
authors.forename: Oh Yoen
authors.initials: OY
authors.lastname: Kim
mesh_terms: D000328:Adult; D000886:Anthropometry; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood / Q000235:genetics; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006720:Homozygote; D006801:Humans; D009765:Obesity / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017697:Premenopause; D056910:Republic of Korea; D012306:Risk; D014280:Triglycerides / Q000097:blood / Q000235:genetics*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D014280:Triglycerides
keywords: APOA5-1131T > C; Body mass index; Human; Obesity; Total energy intake