title: Preparation TiO2 core-shell nanospheres and application as efficiency drug detection sensor.
abstract: In this paper, we report the facile preparation of monodisperse titanium dioxide-diltiazem/tetrachlorobismuth core-shell nanospheres (TiO2@DTMBi), in which, diltiazem (DTM)/tetrachlorobismuth (BiCl4) complexes were employed as electroactive materials. The morphology, size, formation, and structure of the obtained TiO2@DTMBi spheres were investigated by transmission electron microscopy, scanning electron microscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and X-ray diffraction. The optimal condition of obtained monodisperse 40-nm TiO2@DTMBi spheres was researched. The results of using TiO2@DTMBi nanospheres as proposed drug sensor indicate a wide linear range (10(-7) to 10(-1) M) and a very low detection limit of 0.20 μg/mL.
authors.affiliation: School of Material and Metallurgy, Northeastern University, 110004 Shenyang, People's Republic of China ; College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Yue
authors.affiliation: College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: E
authors.affiliation: School of Material and Metallurgy, Northeastern University, 110004 Shenyang, People's Republic of China ; College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
authors.forename: Lianshan
authors.initials: L
authors.lastname: Chen
authors.affiliation: College of Pharmacy, Liaoning Medical University, 121001 Jinzhou, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Nankai University, 300071 Tianjin, People's Republic of China.
authors.forename: Yimeng
authors.initials: Y
authors.lastname: Song
authors.affiliation: School of Material and Metallurgy, Northeastern University, 110004 Shenyang, People's Republic of China.
authors.forename: Yuchun
authors.initials: Y
authors.lastname: Zhai
keywords: Diltiazem hydrochloride; Nanoparticles; Sensors; Titanium dioxide