title: The association between systemic sclerosis, arginine and asymmetric dimethylarginine.
abstract: Systemic sclerosis (SSc) is a kind of autoimmune disease characterized by inflammatory and endothelial dysfunction. Asymmetric dimethylarginine (ADMA), as an endogenous nitric oxide synthase inhibitor, can cause or contribute to the inflammatory syndrome and endothelial dysfunction. Recently, increased ADMA levels have been demonstrated in SSc, revealing that ADMA might play an important role for the associated manifestations of SSc. Besides, ADMA may play a significant role in the level of NO, which is produced by arginine. In the review, we discuss the role of arginine and ADMA in patients with SSc.
authors.affiliation: Medical Genetics Center, Anhui Medical College, Hefei, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Wan
authors.forename: Jiu-Hua
authors.initials: JH
authors.lastname: Zhao
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Wang
authors.forename: Ying-Xin
authors.initials: YX
authors.lastname: Wang
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Yan
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine