title: Methylthio-aspochalasins from a marine-derived fungus Aspergillus sp.
abstract: Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively.
authors.affiliation: Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. liuy620@163.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. zhao.shizhe@163.com.
authors.forename: Shizhe
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. dwj1988555@126.com.
authors.forename: Wanjing
authors.initials: W
authors.lastname: Ding
authors.affiliation: Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. wangpinmei@zju.edu.cn.
authors.forename: Pinmei
authors.initials: P
authors.lastname: Wang
authors.affiliation: CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yangxw76@163.com.
authors.forename: Xianwen
authors.initials: X
authors.lastname: Yang
authors.affiliation: Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China. xujinzhong@zju.edu.cn.
authors.forename: Jinzhong
authors.initials: J
authors.lastname: Xu
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D045744:Cell Line, Tumor; D003572:Cytochalasins / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry*; D045325:HCT116 Cells; D006801:Humans; D033321:Isopoda / Q000382:microbiology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry
chemical_list: D003572:Cytochalasins