title: Development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative.
abstract: The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju daero, Jinju 660-701, Gyeongnam, Korea. ymh@gnu.ac.kr.
authors.forename: Yu Mi
authors.initials: YM
authors.lastname: Heo
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. ryanlee0@snu.ac.kr.
authors.forename: Hunseok
authors.initials: H
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea. ykeeshin@snu.ac.kr.
authors.forename: Young Kee
authors.initials: YK
authors.lastname: Shin
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju daero, Jinju 660-701, Gyeongnam, Korea. million@gnu.ac.kr.
authors.forename: Seung-Mann
authors.initials: SM
authors.lastname: Paek
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D001688:Biological Products / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D055808:Drug Discovery; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D006571:Heterocyclic Compounds