title: Ebola virus disease: potential use of melatonin as a treatment.
abstract: The purpose of this report is to emphasize the potential utility for the use of melatonin in the treatment of individuals who are infected with the Ebola virus. The pathological changes associated with an Ebola infection include, most notably, endothelial disruption, disseminated intravascular coagulation and multiple organ hemorrhage. Melatonin has been shown to target these alterations. Numerous similarities between Ebola virus infection and septic shock have been recognized for more than a decade. Moreover, melatonin has been successfully employed for the treatment of sepsis in many experimental and clinical studies. Based on these factors, as the number of treatments currently available is limited and the useable products are not abundant, the use of melatonin for the treatment of Ebola virus infection is encouraged. Additionally, melatonin has a high safety profile, is readily available and can be orally self-administered; thus, the use of melatonin is compatible with the large scale of this serious outbreak.
authors.affiliation: Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
authors.forename: Dun-Xian
authors.initials: DX
authors.lastname: Tan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Korkmaz
authors.forename: Russel J
authors.initials: RJ
authors.lastname: Reiter
authors.forename: Lucien C
authors.initials: LC
authors.lastname: Manchester
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy*; D006801:Humans; D008550:Melatonin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D008550:Melatonin
keywords: Ebola virus; disseminated intravascular coagulation; endothelial damage; melatonin; multiple organ hemorrhage; sepsis