title: The chromosome 3q25 locus associated with fetal adiposity is not associated with childhood adiposity.
abstract: Increased newborn adiposity is associated with later adverse metabolic outcomes. Previous genome-wide association studies (GWAS) demonstrated strong association of a locus on chromosome 3 (3q25.31) with newborn sum of skinfolds, a measure of overall adiposity. Whether this locus is associated with childhood adiposity is unknown. Genotype and sum of skinfolds data were available for 293 children at birth and age 2, and for 350 children at birth and age 6 from a European cohort (Belfast, UK) who participated in the Hyperglycemia and Adverse Pregnancy Outcome GWAS. We examined single nucleotide polymorphisms (SNPs) at the 3q25.31 locus associated with newborn adiposity. Linear regression analyses under an additive genetic model adjusting for maternal body mass index were performed. In both cohorts, a positive association was observed between all SNPs and sum of skinfolds at birth (P=2.3 × 10(-4), β=0.026 and P=4.8 × 10(-4), β=0.025). At the age of 2 years, a non-significant negative association was observed with sum of skinfolds (P=0.06; β =-0.015). At the age of 6 years, there was no evidence of association (P=0.86; β=0.002). The 3q25.31 locus strongly associated with newborn adiposity had no significant association with childhood adiposity suggesting that its impact may largely be limited to fetal fat accretion.
authors.affiliation: Division of Pediatric Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: R
authors.initials: R
authors.lastname: Chawla
authors.affiliation: 1] The Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK [2] Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
authors.forename: D R
authors.initials: DR
authors.lastname: McCance
authors.affiliation: Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, Northern Ireland, UK.
authors.forename: S
authors.initials: S
authors.lastname: McKenna
authors.affiliation: The Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: I S
authors.initials: IS
authors.lastname: Young
authors.affiliation: The Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
authors.forename: C C
authors.initials: CC
authors.lastname: Patterson
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: J
authors.initials: J
authors.lastname: Rangarajan
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: A C
authors.initials: AC
authors.lastname: Reisetter
authors.affiliation: Division of Endocrinology, Metabolism & Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: L L
authors.initials: LL
authors.lastname: Armstrong
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Lowe
authors.affiliation: Division of Endocrinology, Metabolism & Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Metzger
authors.affiliation: Division of Endocrinology, Metabolism & Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Hayes
authors.affiliation: Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Scholtens
authors.affiliation: Division of Endocrinology, Metabolism & Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Lowe