title: Acylphloroglucinol derivatives from Hypericum andinum: antidepressant-like activity of andinin A.
abstract: A new dimeric acylphloroglucinol derivative, andinin A (1), was isolated from the underground plant parts of Hypericum andinum, along with three known dimeric acylphloroglucinols, uliginosin A (2), uliginosin B (3), and isouliginosin B (4). The structure of 1 was elucidated using 1D and 2D NMR and MS experiments and by comparison with previously reported data for Hypericum dimeric acylphloroglucinols. Andinin A (1) displayed antidepressant-like activity in a mouse forced-swimming test when administered orally at doses of 3, 10, and 30 mg/kg.
authors.affiliation: Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul , Avenida Ipiranga 2752, Porto Alegre/RS 90610-000, Brazil.
authors.forename: Gari V
authors.initials: GV
authors.lastname: Ccana-Ccapatinta
authors.forename: Eveline D
authors.initials: ED
authors.lastname: Stolz
authors.forename: Paola F
authors.initials: PF
authors.lastname: da Costa
authors.forename: Stela M K
authors.initials: SM
authors.lastname: Rates
authors.forename: Gilsane L
authors.initials: GL
authors.lastname: von Poser
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000928:Antidepressive Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D020902:Hypericum / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010568:Peru; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000928:Antidepressive Agents; C000593742:andinin A; D010696:Phloroglucinol; C547933:uliginosin B