title: Aerosol particle generation from solution-based pressurized metered dose inhalers: a technical overview of parameters that influence respiratory deposition.
abstract: There are a multitude of formulation factors to consider when developing a solution-based pressurized metered dose inhaler (pMDI). Evaluation of these variables and their underpinning driving force has been performed over the years. Key components, including formulation composition and device design, play significant roles in determining the aerosol performance of these solution-based formulations. This review outlines research efforts that have focused on these essential governing factors, how the aerosol performance changes when these variables are modified and fundamental mechanisms affecting the delivery efficiency of such formulations.
authors.affiliation: a Respiratory Technology, Woolcock Institute of Medical Research and.|b Discipline of Pharmacology, Faculty of Medicine , The University of Sydney , Sydney , NSW , Australia.
authors.forename: Bing
authors.initials: B
authors.lastname: Zhu
authors.affiliation: a Respiratory Technology, Woolcock Institute of Medical Research and.|b Discipline of Pharmacology, Faculty of Medicine , The University of Sydney , Sydney , NSW , Australia.
authors.forename: Daniela
authors.initials: D
authors.lastname: Traini
authors.affiliation: a Respiratory Technology, Woolcock Institute of Medical Research and.|b Discipline of Pharmacology, Faculty of Medicine , The University of Sydney , Sydney , NSW , Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Young
keywords: Aerosol performance; device variables; formulation variables; particle formation; solution-based pMDI