title: Human induced pluripotent stem cells: A new source for brown and white adipocytes.
abstract: Mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (hiPSCs) provide a novel source for generating adipocytes, thus opening new avenues for fundamental research and clinical medicine. We present the adipogenic potential of hiPSCs and the various methods to derive hiPSC-MSCs. We discuss the main characteristic of hiPSC-MSCs, which is their low adipogenic capacity as compared to adult-MSCs. Finally, we propose several hypotheses to explanation this feature, underlying a potential critical role of the micro-environment. We favour the hypothesis that the range of factors or culture conditions required to induce adipocyte differentiation of MSCs derived from adult tissues and from embryonic-like cells could differ.
authors.affiliation: Anne-Laure Hafner, Christian Dani, Faculté de Médecine, UMR CNRS/INSERM, Université Nice Sophia Antipolis, iBV, 06107 Nice Cedex 2, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Hafner
authors.affiliation: Anne-Laure Hafner, Christian Dani, Faculté de Médecine, UMR CNRS/INSERM, Université Nice Sophia Antipolis, iBV, 06107 Nice Cedex 2, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Dani
keywords: Brown adipocytes; Human induced pluripotent stem cells; Lipodystrophy; Mesenchymal stem cells; Obesity; White adipocytes