title: Oral complications and dental care in children with acute lymphoblastic leukaemia.
abstract: Acute leukaemia is the most common type of childhood cancer, the acute lymphoblastic type accounting for the majority of cases. Children affected by leukaemia receive various forms of treatments including chemotherapeutic agents and stem cell transplants. Leukaemia and its treatment can directly or indirectly affect oral health and further dental treatments. The oral complications include mucositis, opportunistic infections, gingival inflammation and bleeding, xerostomia and carious lesions. An additional consideration in children is the impact of the treatments on the developing dentition and on orofacial growth. The aim of this review is to describe the oral complications in children with acute lymphoblastic leukaemia and the methods of prevention and management before, during and after the cancer treatment.
authors.affiliation: Université Paul Sabatier, Toulouse III, France.|CHU de Toulouse, Service d'odontologie pédiatrique, Toulouse, France.|INSERM U1048, I2MC, Toulouse, France.
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Valéra
authors.affiliation: Université Paul Sabatier, Toulouse III, France.|CHU de Toulouse, Service d'odontologie pédiatrique, Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Noirrit-Esclassan
authors.affiliation: CHU Toulouse, Service d'hématologie pédiatrique, Toulouse, France.|INSERM U1037, CRCT Equipe 16, Toulouse, France.
authors.forename: Marléne
authors.initials: M
authors.lastname: Pasquet
authors.affiliation: Université Paul Sabatier, Toulouse III, France.|CHU de Toulouse, Service d'odontologie pédiatrique, Toulouse, France.
authors.forename: Fréderic
authors.initials: F
authors.lastname: Vaysse
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D019140:Dental Care for Children / Q000379:methods*; D006801:Humans; D009059:Mouth Diseases / Q000517:prevention & control / Q000628:therapy*; D009909:Oral Health; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000009:adverse effects
chemical_list: D000970:Antineoplastic Agents
keywords: acute lymphoblastic leukaemia; dental care