title: Fresh-frozen allografts combined with bovine bone mineral enhance bone formation in sinus augmentation.
abstract: We evaluated histologically, histomorphometrically, and tomographically the effects of the association of fresh-frozen bone allograft (FFB) with bovine bone mineral (BBM) in maxillary sinus floor augmentation. In total, 34 maxillary sinuses from 29 patients, with a mean age of 51.32 (±6.44) years, underwent sinus augmentation. Patients were divided into control and test groups (17 sinuses each). The controls were grafted with allograft bone, and the test group received a combination of FFB and BBM at a 2:1 ratio. After 6 months, bone samples were collected for histological and histomorphometric examinations. The implant survival rates were 93.02% (control group) and 100% (test group) at 6 months after functional loading. Median volumetric reductions of 28.32% (17.05-44.05) and 12.62% (5.65-16.87) were observed for the control and test groups, respectively. Statistically significant histomorphometric differences were found between the control and test groups regarding newly formed bone 12.54% (10.50-13.33) vs. 24.42% (17.62-35.92), p < 0.001, total bone 48.34% (39.03-54.42) vs. 61.32% (50.61-64.96), p = 0.007, and connective tissue 51.66% (45.57-60.97) vs. 39.30% (35.03-49.37), p = 0.007. The addition of BBM to allograft bone in maxillary sinus augmentation resulted in higher percentages of new bone formation and total bone, and permitted implant placement with a low rate of osseointegration failure at the 6-month follow-up.
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil.
authors.forename: Felipe Perraro
authors.initials: FP
authors.lastname: Sehn
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil.
authors.forename: Rafael Rodrigues
authors.initials: RR
authors.lastname: Dias
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil.
authors.forename: Thiago
authors.initials: T
authors.lastname: de Santana Santos
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil.
authors.forename: Erick Ricardo
authors.initials: ER
authors.lastname: Silva
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil.
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Salata
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Tel Aviv University, Israel.
authors.forename: Gavriel
authors.initials: G
authors.lastname: Chaushu
authors.affiliation: Department of Oral and Maxillofacial Surgery and Periodontology. Ribeirão Preto Dental School, University of São Paulo, São Paulo, Brazil samuelpxavier@yahoo.com.br.
authors.forename: Samuel Porfírio
authors.initials: SP
authors.lastname: Xavier
mesh_terms: D000328:Adult; D064591:Allografts; D000818:Animals; D001672:Biocompatible Materials; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D008875:Middle Aged; D008903:Minerals / Q000008:administration & dosage*; D010012:Osteogenesis; D011446:Prospective Studies; D059546:Sinus Floor Augmentation / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D008903:Minerals
keywords: Fresh-frozen bone allograft; bone volume; bovine bone mineral; computed tomography; histology; histomorphometry; maxillary sinus