title: Aberrant expression of caspase 14 in salivary gland carcinomas.
abstract: OBJECTIVE
  Caspase 14 is reduced in adenocarcinomas of the stomach and colon. In contrast, breast and lung adenocarcinomas frequently show an overexpression of caspase 14. Salivary gland adenocarcinomas have not been evaluated for potential aberrant caspase 14 expression.
  
  
  METHODS
  Samples from salivary gland carcinomas (n = 43) were analysed by immunohistochemistry (caspase 14, filaggrin, GATA3 and Ki67) and fluorescence in situ hybridization.
  
  
  RESULTS
  Caspase 14 is not expressed in normal salivary glands, while in a subfraction of carcinomas (32%) an aberrant expression was found. Filaggrin could not be detected. Caspase 14 staining was not associated with tumour dedifferentiation, GATA3 expression or amplification of gene locus 19p13.
  
  
  CONCLUSIONS
  In summary, aberrant expression of caspase 14 can be found in a subfraction of salivary gland carcinomas but could not be used as a biomarker for a specific carcinoma subtype of the salivary gland.
authors.affiliation: Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Juliana
authors.initials: J
authors.lastname: Lemound
authors.affiliation: Institute of Pathology, Hannover Medical School, Hannover, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Stucki-Koch
authors.affiliation: Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Stoetzer
authors.affiliation: Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Horst
authors.initials: H
authors.lastname: Kokemüller
authors.affiliation: Department of Craniomaxillofacial Surgery, Hannover Medical School, Hannover, Germany.
authors.forename: Nils-Claudius
authors.initials: NC
authors.lastname: Gellrich
authors.affiliation: Institute of Pathology, Hannover Medical School, Hannover, Germany.
authors.forename: Hans
authors.initials: H
authors.lastname: Kreipe
authors.affiliation: Institute of Pathology, Hannover Medical School, Hannover, Germany.
authors.forename: Kais
authors.initials: K
authors.lastname: Hussein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D053456:Caspase 14 / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D000091344:Filaggrin Proteins; D050990:GATA3 Transcription Factor / Q000096:biosynthesis; D005784:Gene Amplification; D056426:Genetic Loci; D006258:Head and Neck Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007381:Intermediate Filament Proteins / Q000096:biosynthesis; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D007381:Intermediate Filament Proteins; D019394:Ki-67 Antigen; D053456:Caspase 14
keywords: GATA3; caspase 14; filaggrin; salivary gland carcinoma