title: Meniscus transplantation in an active population with moderate to severe cartilage damage.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the efficacy of meniscus allograft transplantation in an active patient population with moderate to severe cartilage damage and the procedure's ability to allow sports participation postoperatively.
  
  
  METHODS
  Forty-nine patients with moderate to severe cartilage damage who underwent meniscus allograft transplantation were included in this study; those with symptoms related to articular cartilage damage also underwent articular cartilage repair. Kaplan-Meier (KM) survival estimate, potential hazards to survival, and subjective clinical outcomes were analyzed. For KM survival, failure was defined as progression to knee arthroplasty, surgical removal of the meniscus transplant without revision, a self-reported follow-up pain level that was more than preoperative level, or constant moderate pain with no relief from non-operative treatment.
  
  
  RESULTS
  The mean follow-up time was 8.6 ± 4.2 years. The mean age at surgery was 45.3 ± 12.9 years. Meniscus transplantation was performed in 37 medial cases and 12 lateral cases. There were 41 patients with Outerbridge Grade IV and 8 with Grade III. Thirty-six (73.5%) patients were able to participate in sporting activities postoperatively. Eleven (22.4%) meniscus transplants failed at an average of 5.2 ± 4.4 years. The KM mean estimated survival time was 12.6 ± 0.7 years. No tested risks were found to affect sports participation or procedure success.
  
  
  CONCLUSIONS
  Meniscus transplantation is a viable surgical option for patients with severe cartilage damage and missing or irreparable menisci to provide significant improvements in pain and function levels in the medium to long term with the majority of patients achieving their goal of participation in sporting activities. These results indicate that symptomatic patients may be able to participate in sports activities for an average of 12.6 years following meniscus transplantation.
  
  
  METHODS
  Case series, Level IV.
authors.affiliation: Stone Research Foundation, San Francisco, CA, USA, kstonemd@stoneclinic.com.
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Stone
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Pelsis
authors.forename: Scott T
authors.initials: ST
authors.lastname: Surrette
authors.forename: Ann W
authors.initials: AW
authors.lastname: Walgenbach
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Turek
mesh_terms: D000328:Adult; D002356:Cartilage / Q000637:transplantation; D002357:Cartilage Diseases / Q000601:surgery*; D002358:Cartilage, Articular / Q000293:injuries / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D008297:Male; D008592:Menisci, Tibial / Q000637:transplantation*; D008875:Middle Aged; D013177:Sports; D014184:Transplantation, Homologous