title: Protein-based fluorescent metal nanoclusters for small molecular drug screening.
abstract: A facile drug screening method based on synthesis of fluorescent gold nanoclusters inside albumin proteins loaded with small molecular drugs and comparing the relative fluorescence intensities of the resultant gold nanoclusters has been developed and successfully applied for the quantitative measurement of drug-protein binding constants.
authors.affiliation: Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602. tanyn@imre.a-star.edu.sg xd-su@imre.a-star.edu.sg.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yu
authors.forename: Siu Yee
authors.initials: SY
authors.lastname: New
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Su
authors.forename: Yen Nee
authors.initials: YN
authors.lastname: Tan
mesh_terms: D004353:Drug Evaluation, Preclinical; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D010672:Phenytoin / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry*; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000737:chemistry; D014859:Warfarin / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D012709:Serum Albumin; D013424:Sulfanilamides; D000077145:Sulfanilamide; D014859:Warfarin; D010672:Phenytoin; D006046:Gold; D007052:Ibuprofen