title: The menstrual cycle regularization following D-chiro-inositol treatment in PCOS women: a retrospective study.
abstract: Polycystic ovary syndrome is characterized by irregular cycles, hyperandrogenism, polycystic ovary at ultrasound and insulin resistance. The effectiveness of D-chiro-inositol (DCI) treatment in improving insulin resistance in PCOS patients has been confirmed in several reports. The objective of this study was to retrospectively analyze the effect of DCI on menstrual cycle regularity in PCOS women. This was a retrospective study of patients with irregular cycles who were treated with DCI. Of all PCOS women admitted to our centre, 47 were treated with DCI and had complete medical charts. The percentage of women reporting regular menstrual cycles significantly increased with increasing duration of DCI treatment (24% and 51.6% at a mean of 6 and 15 months of treatment, respectively). Serum AMH levels and indexes of insulin resistance significantly decreased during the treatment. Low AMH levels, high HOMA index, and the presence of oligomenorrhea at the first visit were the independent predictors of obtaining regular menstrual cycle with DCI. In conclusion, the use of DCI is associated to clinical benefits for many women affected by PCOS including the improvement in insulin resistance and menstrual cycle regularity. Responders to the treatment may be identified on the basis of menstrual irregularity and hormonal or metabolic markers.
authors.affiliation: Mother-Infant Department, Institute of Obstetrics and Gynaecology, University of Modena and Reggio Emilia , Modena , Italy and.
authors.forename: Antonio
authors.initials: A
authors.lastname: La Marca
authors.forename: Valentina
authors.initials: V
authors.lastname: Grisendi
authors.forename: Giulia
authors.initials: G
authors.lastname: Dondi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sighinolfi
authors.forename: Antonio
authors.initials: A
authors.lastname: Cianci
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood; D005260:Female; D006801:Humans; D007294:Inositol / Q000494:pharmacology* / Q000627:therapeutic use; D008597:Menstrual Cycle / Q000097:blood / Q000187:drug effects*; D008599:Menstruation Disturbances / Q000097:blood / Q000188:drug therapy*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007294:Inositol; D054304:Anti-Mullerian Hormone
keywords: AMH; D-chiro-inositol; PCOS; insulin resistance