title: Regional amyloid burden and intrinsic connectivity networks in cognitively normal elderly subjects.
abstract: Although previous studies demonstrated decreased functional connectivity in the default mode network in the cognitively normal older adults with amyloid burden, effects of amyloid burden in the other large-scale intrinsic connectivity networks are not yet clear. The aim of this study was to investigate the distinctive association pattern of amyloid-β deposition on the three large-scale intrinsic connectivity networks (the default mode network, salience network and central executive network) in older adults with normal cognition. Fifty-six older adults with normal cognition underwent functional magnetic resonance imaging and were dichotomized using 11C-labelled Pittsburgh compound B positron emission tomography imaging into subjects with (PiB+; n=27) and without (PiB-; n=29) detectable amyloid burden. We found that the functional connectivities of (i) the default mode network were greater; (ii) the salience network were not different; and (iii) the central executive network were lower in the Pittsburgh compound B positive group, compared with the Pittsburgh compound B negative group. Anterior cingulate cortex Pittsburgh compound B retention was negatively correlated with the functional connectivities of the posterior default mode network, and positively correlated with fronto-parietal functional connectivity (within the central executive network) in the Pittsburgh compound B positive group. The anti-correlation strength between the default mode network and the central executive network was negatively correlated with the anterior cingulate cortex Pittsburgh compound B levels. Additionally, significant group × episodic memory interactions with functional connectivities in the posterior default mode network, and the frontal default mode network were observed. Our results of aberrant default mode network functional connectivity and distinctive correlation patterns between the Pittsburgh compound B retention in the anterior cingulate cortex and functional connectivities in the default mode network and central executive network in the Pittsburgh compound B positive group might reflect a detrimental effect of amyloid retention on functional changes in the course of Alzheimer's disease progression.
authors.affiliation: 1 Department of Psychiatry, The Saint Vincent Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea 2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Hyun Kook
authors.initials: HK
authors.lastname: Lim
authors.affiliation: 2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Nebes
authors.affiliation: 3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Beth
authors.initials: B
authors.lastname: Snitz
authors.affiliation: 2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Cohen
authors.affiliation: 4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Chester
authors.initials: C
authors.lastname: Mathis
authors.affiliation: 4 Department of Radiology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Price
authors.affiliation: 5 Department of Biostatistics University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Weissfeld
authors.affiliation: 2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA 3 Department of Neurology, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.
authors.forename: William
authors.initials: W
authors.lastname: Klunk
authors.affiliation: 2 Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA haizenstein@gmail.com.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Aizenstein
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D000682:Amyloid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests
chemical_list: D000682:Amyloid
keywords: amyloid imaging; functional MRI; large scale intrinsic networks; normal older adults