title: Sociodemographic trends in the incidence of pancreatic and biliary tract cancer in UK primary care.
abstract: BACKGROUND
  The UK incidence of pancreatic ductal adenocarcinoma (PDAC) is approximately 9/100,000 population compared with 1-2/100,000 for biliary tract cancer (BTC). This study explores the incidence of these cancers over time and the influence of socio-demographic and geographic factors in a UK primary care cohort.
  
  
  METHODS
  This study uses data from a large UK primary care database, The Health Improvement Network (THIN). All adult patients contributing data to THIN between January 2000 and December 2010 were included. Annual incidence rates were calculated, adjusted for age, gender, time period, deprivation score (Townsend quintile) and strategic health authority.
  
  
  RESULTS
  From 2000-2010, the annual incidence of PDAC increased by an average of 3% per year (95% CI 1.00-4.00%) and BTC by 4% (95% CI 2.00-6.00%). Incidence of both cancers increased steeply with age and was higher in men. BTC was associated with increasing deprivation (most deprived versus least deprived quintile (OR: 1.45 [95% CI: 1.17, 1.79.]).
  
  
  CONCLUSIONS
  The overall incidence of both cancers is low but increasing. Variations in incidence may reflect changes in coding practice or increased exposure to associated risk factors.
authors.affiliation: Institute for Liver and Digestive Health, University College London, London, United Kingdom.
authors.forename: Margaret G
authors.initials: MG
authors.lastname: Keane
authors.affiliation: Research Department of Primary Care and Population Health, University College London, London, United Kingdom.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Horsfall
authors.affiliation: Research Department of Primary Care and Population Health, University College London, London, United Kingdom.
authors.forename: Greta
authors.initials: G
authors.lastname: Rait
authors.affiliation: Institute for Liver and Digestive Health, University College London, London, United Kingdom.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Pereira
mesh_terms: D000230:Adenocarcinoma / Q000191:economics / Q000453:epidemiology*; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001661:Biliary Tract Neoplasms / Q000191:economics / Q000453:epidemiology*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000191:economics / Q000453:epidemiology*; D011320:Primary Health Care / Q000706:statistics & numerical data*; D012307:Risk Factors; D012737:Sex Factors; D012923:Social Class; D006113:United Kingdom / Q000453:epidemiology