title: Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia.
abstract: A 20 year old male was initially diagnosed suffering from Primary ciliary dyskinesia with symptoms of bronchiectasis, severe frontal, maxillary and ethmoid sinus disease. At the age of 20, the patient was also diagnosed with Myelodysplastic syndrome requiring Bone marrow transplant due to the advanced stage at time of presentation. Primary ciliary dyskinesia and Myelodsyplastic syndrome are both rare clinical conditions found in the general population, especially in young adults. This rare combination of disorders has never been reported in literature to the best of the author's knowledge. The presence of an advanced cancer and a genetic abnormality due to two deletions occurring in two arms of the same chromosome can be explained on the base of chromothripsis. A number of evidences have been published in the literature, about multiple deletions in chromosome 5 and advanced stages of MDS being associated with chromothripsis however this is the first case report on two deletions in chromosome 7 giving rise to two different clinical entities requiring multiple modes of management.
authors.affiliation: Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
authors.forename: Abhinav
authors.identifier: 0000-0003-1080-6449
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
authors.forename: Anar
authors.identifier: 0000-0001-9589-119X
authors.initials: A
authors.lastname: Modi
authors.affiliation: Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
authors.forename: Sayee Sundar
authors.identifier: 0000-0002-9546-8145
authors.initials: SS
authors.lastname: Alagusundaramoorthy
authors.affiliation: Department of Internal Medicine, Monmouth Medical Center, Long Branch, NJ 07740, USA.
authors.forename: Wael
authors.initials: W
authors.lastname: Ghali