title: Diffuse melanosis cutis in the setting of BRAF(V600E) metastatic melanoma.
abstract: METHODS
  A 79-year-old Caucasian male presented with a 1-week history of diffuse progressive blue-gray discoloration of the skin subsequently found to due to diffuse melanosis cutis (DMC) in the setting of metastatic melanoma. Mutation testing demonstrated BRAF(V600E) mutation status, an unexpected finding given his age. He died two weeks after presentation.
  
  
  CONCLUSIONS
  As our understanding of the molecular subtypes of melanoma increases, in the future it may be possible to predict which melanoma patients have a predilection to developing DMC. Mutation testing of DMC patients should be considered as BRAF inhibitors, and other novel targeted therapies may improve the bleak prognosis associated with this unusual presentation of metastatic melanoma.
authors.affiliation: Department of Dermatology, St George Hospital, Sydney, NSW, Australia; Faculty of Medicine, University of New South Wales, Kensington, NSW, Australia.
authors.forename: Deshan F
authors.initials: DF
authors.lastname: Sebaratnam
authors.forename: Linda K
authors.initials: LK
authors.lastname: Martin
authors.forename: Supriya S
authors.initials: SS
authors.lastname: Venugopal
authors.forename: George
authors.initials: G
authors.lastname: Mangos
authors.forename: John
authors.initials: J
authors.lastname: Freiman
authors.forename: Paul
authors.initials: P
authors.lastname: de Souza
authors.forename: Annabelle
authors.initials: A
authors.lastname: Farnsworth
authors.forename: Karen
authors.initials: K
authors.lastname: Cheung
authors.forename: Richard A
authors.initials: RA
authors.lastname: Scolyer
authors.forename: Dédée F
authors.initials: DF
authors.lastname: Murrell
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000235:genetics / Q000556:secondary; D008548:Melanosis / Q000150:complications* / Q000473:pathology; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics*; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology
chemical_list: D048493:Proto-Oncogene Proteins B-raf