title: Demystifying NUT midline carcinoma: radiologic and pathologic correlations of an aggressive malignancy.
abstract: OBJECTIVE
  NUT midline carcinoma is a rare poorly differentiated aggressive subtype of squamous cell carcinoma. To date, fewer than 100 total cases have been reported.
  
  
  CONCLUSIONS
  Given the rarity of this disease process and lack of pathognomonic imaging findings, a definitive diagnosis based solely on imaging findings alone is untenable. Select cases are used to emphasize the particularly infiltrative and aggressive nature of NUT midline carcinoma, which shows a complete disregard for normal tissue boundaries and rapid progression during brief intervals.
authors.affiliation: 1 Department of Radiology, Division of Thoracic Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Bair
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Chick
authors.forename: Nikunj R
authors.initials: NR
authors.lastname: Chauhan
authors.forename: Christopher
authors.initials: C
authors.lastname: French
authors.forename: Rachna
authors.initials: R
authors.lastname: Madan
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000235:genetics; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000235:genetics; D055815:Young Adult
chemical_list: C000630260:NUTM1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins
keywords: NUT midline carcinoma; aggressive malignancy; genetic typing