title: Occurrence and prognostic relevance of CD30 expression in post-transplant lymphoproliferative disorders.
abstract: Post-transplant lymphoproliferative disorders (PTLDs) are potentially fatal, often Epstein-Barr virus (EBV)-driven neoplasias developing in immunocompromised hosts. Initial treatment usually consists of a reduction in immunosuppressive therapy and/or rituximab with or without chemotherapy. However, patients who relapse do poorly, and new treatment options are warranted. With the introduction of the immunoconjugate brentuximab vedotin, the CD30 antigen has become an effectively targetable molecule. Therefore, we investigated the frequency and level of CD30 expression in PTLDs. We identified 108 patients with PTLDs diagnosed during 1994-2011, of whom 62 had adequate paraffin-embedded tissue for tissue microarray construction. Immunohistochemical expression of CD30 was consistently detected in all types of PTLD (overall 85.25%), including the monomorphic subtypes, and was correlated with a more favorable outcome. For diffuse large B-cell lymphoma (DLBCL)-type PTLD this was regardless of EBV status, and remained significant in multivariate analysis. Cell-of-origin had no independent prognostic value in our series of DLBCL PTLD.
authors.affiliation: Department of Hematology, Aarhus University Hospital , Aarhus , Denmark.
authors.forename: Maja Ølholm
authors.initials: MØ
authors.lastname: Vase
authors.forename: Eva Futtrup
authors.initials: EF
authors.lastname: Maksten
authors.forename: Knud
authors.initials: K
authors.lastname: Bendix
authors.forename: Stephen
authors.initials: S
authors.lastname: Hamilton-Dutoit
authors.forename: Claus
authors.initials: C
authors.lastname: Andersen
authors.forename: Michael Boe
authors.initials: MB
authors.lastname: Møller
authors.forename: Søren Schwartz
authors.initials: SS
authors.lastname: Sørensen
authors.forename: Bente
authors.initials: B
authors.lastname: Jespersen
authors.forename: Jan
authors.initials: J
authors.lastname: Kampmann
authors.forename: Esben
authors.initials: E
authors.lastname: Søndergård
authors.forename: Patricia Switten
authors.initials: PS
authors.lastname: Nielsen
authors.forename: Francesco
authors.initials: F
authors.lastname: D'amore
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000378:metabolism / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D017730:Ki-1 Antigen / Q000378:metabolism*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000378:metabolism / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D011183:Postoperative Complications; D011379:Prognosis; D046888:Tissue Array Analysis; D055815:Young Adult
chemical_list: D017730:Ki-1 Antigen
keywords: CD30; EBV; PTLD; cell-of-origin