title: Synthesis, leishmanicidal activity and theoretical evaluations of a series of substituted bis-2-hydroxy-1,4-naphthoquinones.
abstract: A series of eight substituted bis-2-hydroxy-1,4-naphthoquinone derivatives was synthesized through lawsone condensation with various aromatic and aliphatic aldehydes under mild acidic conditions. The title compounds were evaluated for antileishmanial activity in vitro against Leishmania amazonensis and Leishmania braziliensis promastigotes; six compounds showed good activity without significant toxic effects. The compound with the highest activity was used for an in vivo assay with Leishmania amazonensis.
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. morgana_vital@hotmail.com.
authors.forename: Morgana V
authors.initials: MV
authors.lastname: de Araújo
authors.affiliation: Laboratory of Bioactive Compounds Synthesis, Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil. patti.soliveira@gmail.com.
authors.forename: Patricia S O
authors.initials: PS
authors.lastname: de Souza
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. allycq_farmacia@hotmail.com.
authors.forename: Aline C
authors.initials: AC
authors.lastname: de Queiroz
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. carolina_damatta@hotmail.com.
authors.forename: Carolina B B
authors.initials: CB
authors.lastname: da Matta
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. bioufal@hotmail.com.
authors.forename: Anderson Brandão
authors.initials: AB
authors.lastname: Leite
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. Amanda.evelyn13@hotmail.com.
authors.forename: Amanda Evelyn
authors.initials: AE
authors.lastname: da Silva
authors.affiliation: Laboratory of Bioactive Compounds Synthesis, Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil. adoniass@gmail.com.
authors.forename: José A A
authors.initials: JA
authors.lastname: de França
authors.affiliation: Laboratory of Bioactive Compounds Synthesis, Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil. sarmentosilva@gmail.com.
authors.forename: Tania M S
authors.initials: TM
authors.lastname: Silva
authors.affiliation: Laboratory of Bioactive Compounds Synthesis, Molecular Sciences Department, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil. ccelso@gmail.com.
authors.forename: Celso A
authors.initials: CA
authors.lastname: Camara
authors.affiliation: Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, Maceió, AL 57020-720, Brazil. suzana.magna@gmail.com.
authors.forename: Magna S
authors.initials: MS
authors.lastname: Alexandre-Moreira
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007891:Leishmania / Q000145:classification / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones