title: Two smart spectrophotometric methods for the simultaneous estimation of Simvastatin and Ezetimibe in combined dosage form.
abstract: Two simple, accurate, precise, sensitive and economic spectrophotometric methods were developed for the simultaneous determination of Simvastatin and Ezetimibe in fixed dose combination products without prior separation. The first method depends on a new chemometrics-assisted ratio spectra derivative method using moving window polynomial least square fitting method (Savitzky-Golay filters). The second method is based on a simple modification for the ratio subtraction method. The suggested methods were validated according to USP guidelines and can be applied for routine quality control testing.
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.
authors.forename: Nancy
authors.initials: N
authors.lastname: Magdy
authors.affiliation: Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Egypt.
authors.forename: Miriam F
authors.initials: MF
authors.lastname: Ayad
mesh_terms: D000924:Anticholesteremic Agents / Q000032:analysis; D001384:Azetidines / Q000032:analysis*; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D004345:Drug Industry; D000069438:Ezetimibe; D016018:Least-Squares Analysis; D057230:Limit of Detection; D008962:Models, Theoretical; D011786:Quality Control; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D019821:Simvastatin / Q000032:analysis*; D012984:Software; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D004338:Drug Combinations; D019821:Simvastatin; D000069438:Ezetimibe
keywords: Ezetimibe; Savitzky-Golay; Simvastatin; Spectrophotometry