title: Glycation of human serum albumin in diabetes: impacts on the structure and function.
abstract: Diabetes mellitus is one of the most serious diseases in the world. The levels of glycated proteins in the blood of diabetics are higher than that of non-diabetic subjects. The glycation of proteins is believed to link to the occurrence of diabetic complications and related diseases. This review focuses on the influence of glycation of human serum albumin (HSA) on its structure and function. The glycation leads to change the HSA conformation, which will further influence its ligand binding properties. The levels of glycated HSA in hyperglycemic conditions showed a significant relationship to the germination of serious complications for diabetics, especially by affecting various cells functions. The conclusion from individual report is contradictory to each other; therefore, it is very difficult to give an univocal comment on the impact of glycation on the binding behaviors of HSA for small molecules. The influence of glycation of HSA on the binding affinities for small molecules is decided by the assay, the structures of small molecules, as well as the degree of glycation. However, the glycation of HSA is believed to reduce the binding affinities for acidic drugs such as polyphenols and phenolic acids.
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Tingting
authors.initials: T
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Nantong University, Nantong, 226019, PR China. hui_cao0830@yahoo.com.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Shi
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology*; D017127:Glycation End Products, Advanced; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism; D011485:Protein Binding; D012709:Serum Albumin / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry / Q000378:metabolism; D000093423:Glycated Serum Albumin
chemical_list: D001688:Biological Products; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D054852:Small Molecule Libraries; D019255:NADPH Oxidases; D000093423:Glycated Serum Albumin