title: Doppler ultrasonographic evaluation of the carotid and vertebral arteries in children with Crimean-Congo hemorrhagic fever.
abstract: OBJECTIVE
  In children with Crimean-Congo hemorrhagic fever (CCHF), the aim of present study was to determine the cerebral hemodynamic changes assessed with Doppler ultrasonography with measurements of lumen diameter (LD), peak systolic velocity (PSV), end-diastolic velocity (EDV), resistive index (RI), pulsatility index (PI), and total cerebral blood flow volume (tCBFV) of common carotid artery (CCA), internal carotid artery (ICA, and vertebral artery (VA).
  
  
  METHODS
  This case-control study examined children with clinically defined CCHF as cases (N.=24) and healthy children as controls (N.=17). The CCHF and healthy children underwent ultrasonography of the CCA, ICA and VA for the measurements of flow velocity and cerebral blood flow volume. Doppler ultrasonography were performed in the CCHF children if vital signs were stable and fever lower than 37.5 °C.
  
  
  RESULTS
  There was no significant difference between the CCHF and healthy children in the lumen diameter of study arteries (P>0.05). PSV and EDV values were significantly higher in the CCHF children compared to the controls (P<0.05). Overall, the CCHF did not cause considerable change in RI and PI values (P>0.05). tCBFV values of CCHF children was found higher compared to healthy controls (P<0.05).
  
  
  CONCLUSIONS
  Overall, in children, CCHF causes an increase in the cerebral blood flow as determined by Doppler ultrasonography with flow velocity and cerebral blood flow volume measurements; however, this increase need to be accepted as mild to moderate degree. Several pathophysiological derangements may be contributory to the increased cerebral blood flow in children with CCHF.
authors.affiliation: Department of Radiology, Cumhuriyet University Faculty of Medicine, Sivas, Turkey - ismailsalk@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Salk
authors.forename: A
authors.initials: A
authors.lastname: Kaya
authors.forename: G
authors.initials: G
authors.lastname: Cetin
authors.forename: H
authors.initials: H
authors.lastname: Egilmez
authors.forename: M
authors.initials: M
authors.lastname: Haydar Atalar
authors.forename: A
authors.initials: A
authors.lastname: Cetin
mesh_terms: D000293:Adolescent; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging*; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006479:Hemorrhagic Fever, Crimean / Q000097:blood / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D018608:Ultrasonography, Doppler / Q000379:methods; D014711:Vertebral Artery / Q000000981:diagnostic imaging*