title: Synthesis and antibacterial activity of analogs of 5-arylidene-3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazoli-din-4-one.
abstract: In an effort to develop new antimicrobial agents, 3-(4-methylcoumarin-7-yloxyacetylamino)-2-thioxo-1,3-thiazolidin-4-one (4) was synthesized by reaction of thiocarbonylbisthioglycolic acid with ethyl (4-methyl-2-oxo-2H-chromen-7-yloxy)aceto- hydrazide (3), which was prepared in turn from 7-hydroxy-4-methylcoumarin (1). The condensation of compound 4 with different aromatic aldehydes afforded a series of 5-(arylidene)-3-(4-methylcoumarin-7-yloxyacetyl-amino)-2-thioxo-1,3-thiozolidin-4-one analogs 5a-h. The structures of these synthetic compounds were elucidated on the basis of IR, 1H-NMR and 13C-NMR spectral data and ESI-MS spectrometric analysis. Compounds 5a-h were examined for their antibacterial activity against several strains of Gram-positive and Gram-negative bacteria.
authors.affiliation: Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam. congchemist@gmail.com.
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Cong
authors.affiliation: Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam. nhanhuynhsp@gmail.com.
authors.forename: Huynh Thi
authors.initials: HT
authors.lastname: Nhan
authors.affiliation: Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City 70000, Vietnam. luonghung365@gmail.com.
authors.forename: Luong
authors.initials: L
authors.lastname: Van Hung
authors.affiliation: Department of Chemistry, Vinh University, Vinh 42000, Vietnam. thangtd@vinhuni.edu.vn.
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin 63201, Taiwan. pcckuoo@sunws.nfu.edu.tw.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins