title: Mangiferin loaded magnetic PCEC microspheres: preparation, characterization and antitumor activity studies in vitro.
abstract: Mangiferin is a promising effective chemopreventive agent against various tumors. However, its clinical use is limited by poor water solubility and low bioavailability. In this article, mangiferin loaded magnetic PCEC microspheres (MG-MS) were designed, characterized and the antitumor activity of MG-MS was evaluated in vitro. The magnetic nanoparticles (MNP) were synthesized via the high-temperature reaction of iron acetylacetonate in phenyl ether in the presence of oleic acid and oleylamine. Poly (ε-caprolactone)-poly (ethyleneglycol)-poly (ε-caprolactone) (PCL-PEG-PCL, PCEC) copolymers were formed by ring-opening copolymerization of ε-CL initiated by PEG-diol using Sn(Oct)2as a catalyst and MG-MS were prepared by solvent diffusion method. MNP, PCEC copolymer, and MG-MS were characterized by GPC, TEM, XRD, FT-IR,1H-NMP and Malvern Laser Particle Sizer. Meanwhile, the antiproliferative activity in vitro and in vitro release behavior of this microspheres were studied in detail. The results indicate that the obtained magnetic microspheres might have great potential as an effective carrier for mangiferin used in cancer chemotherapy.
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: WenJing
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Hou
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: BoTao
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: JianDong
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: WeiHua
authors.initials: W
authors.lastname: Jin
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.affiliation: 71602 Medical Crop of People's Liberation Army, Weifang, 261055, People's Republic of China.
authors.forename: DeZhi
authors.initials: D
authors.lastname: Zheng
authors.affiliation: Department of Pharmacy, Chengdu Military General Hospital, No.270, Rongdu Avenue, Jinniu District, Chengdu, 610083, Sichuan, People's Republic of China. fankh2012@hotmail.com.
authors.forename: KaiHua
authors.initials: K
authors.lastname: Fan
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D006801:Humans; D060328:Magnetic Phenomena; D008863:Microspheres; D009369:Neoplasms / Q000188:drug therapy; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D044004:Xanthones / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011091:Polyesters; D044004:Xanthones; C515340:poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); C013592:mangiferin; D011092:Polyethylene Glycols
keywords: Antitumor; Magnetic microspheres; Magnetite nanoparticles; Mangiferin; PCEC