title: [Carriers of haemophilia: Experience of a French university hospital].
abstract: OBJECTIVE
  To report the management of carriers of haemophilia in a French university hospital and assess different issues of these patients.
  
  
  METHODS
  Retrospective study of the carriers of haemophilia who consulted at the university hospital of Montpellier, France, between 1995 and 2011. Information were obtained from medical records and from a questionnaire sent to carriers. We recorded data about biological characteristics, bleeding tendency and management of pregnancies.
  
  
  RESULTS
  Sixty-four carriers of haemophilia A or B were included. Their median FVIII or FIX level was 52 % (range, 15-137 %). Menstrual bleeding lasted more than 7 days in 31 % of carriers. A total of 142 pregnancies started in 54 carriers, and 101 resulted in live births with 26 boys with haemophilia. Sixty-two prenatal diagnoses carried out, 15 have terminated their pregnancy because of a hemophiliac male fetus. Seventy-six percent of deliveries were vaginal delivery and 49 % took place in a level-3 maternity. There were 10.8 % and 8.5 % primary and secondary post-partum hemorrhage, respectively.
  
  
  CONCLUSIONS
  The risk of bleeding among carriers of haemophilia is associated with their antihemophilic factor level. To improve the management of carriers, a multidisciplinary and standardized medical record, with a specific questionnaire to evaluate bleedings, could be considered. A regional register that lists all carriers, regardless of their antihemophilic factor level, would also be useful.
authors.affiliation: Département d'hématologie biologique et centre régional de traitement de l'hémophilie, pôle biologie-pathologie, hôpital Saint-Eloi, CHRU Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Sauguet
authors.affiliation: Département d'hématologie biologique et centre régional de traitement de l'hémophilie, pôle biologie-pathologie, hôpital Saint-Eloi, CHRU Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Aguilar-Martinez
authors.affiliation: Département de gynécologie-obstétrique, pôle naissance et pathologies de la femme, hôpital Arnaud-de-Villeneuve, CHRU Montpellier, 37, avenue du Doyen-Gaston-Giraud, 34295 Montpellier cedex 05, France.
authors.forename: P
authors.initials: P
authors.lastname: Boulot
authors.affiliation: Département information médicale, CHRU Montpellier, 34295 Montpellier cedex 05, France.
authors.forename: J-B
authors.initials: JB
authors.lastname: Escudié
authors.affiliation: Département d'hématologie biologique et centre régional de traitement de l'hémophilie, pôle biologie-pathologie, hôpital Saint-Eloi, CHRU Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 05, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Schved
authors.affiliation: Département d'hématologie biologique et centre régional de traitement de l'hémophilie, pôle biologie-pathologie, hôpital Saint-Eloi, CHRU Montpellier, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 05, France. Electronic address: c-biron@chu-montpellier.fr.
authors.forename: C
authors.initials: C
authors.lastname: Biron-Andréani
mesh_terms: D000025:Abortion, Eugenic / Q000706:statistics & numerical data; D000328:Adult; D005260:Female; D005602:France; D006467:Hemophilia A / Q000097:blood* / Q000453:epidemiology; D002836:Hemophilia B / Q000097:blood* / Q000453:epidemiology; D006579:Heterozygote; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood* / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*
keywords: Bleeding; Carriers of haemophilia; Conductrices d’hémophilie; Diagnostic prénatal; Grossesse; Hémorragie; Hémorragie du post-partum; Post-partum hemorrhage; Pregnancy; Prenatal diagnosis