title: Wound healing activity of an aqueous extract of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes).
abstract: The Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes) is popular because of its health-promoting properties. The effects of G. lucidum extract on cancer, hypertension, hypercholesterolemia, and hepatitis have been reported by many researchers. This investigation was undertaken to evaluate the healing efficacy of an aqueous lyophilized extract of G. lucidum from the Indian Himalayan region on dermal excision wound in experimental rats. The extract used in the study was found to be rich in total polyphenol and flavonoid contents. The healing efficacy was comparatively assessed with a reference povidone-iodine ointment. The G. lucidum extract showed significant enhanced healing activity, evidenced by an increase in wound contraction, collagen accumulation (hydroxyproline), hexosamine, and total protein contents. Histopathological findings further supported the biochemical indices. The results suggest that aqueous lyophilized extract of G. lucidum possesses significant wound-healing activity.
authors.affiliation: Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India.
authors.forename: Asheesh
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Kirar
authors.affiliation: Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India.
authors.forename: Gaurav Kr
authors.initials: GK
authors.lastname: Keshri
authors.affiliation: Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India.
authors.forename: Shefali
authors.initials: S
authors.lastname: Gola
authors.affiliation: Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Timarpur, Delhi, India.
authors.forename: Anju
authors.initials: A
authors.lastname: Yadav
authors.affiliation: Defence Agricultural Research Laboratory, Pithoragarh, Uttarakhand, 262 501 India ; Defence Institute of Bio-Energy Research, Haldwani, India.
authors.forename: Prem Singh
authors.initials: PS
authors.lastname: Negi
authors.affiliation: Defence Institute of Physiology & Allied Sciences.
authors.forename: Kshipra
authors.initials: K
authors.lastname: Misra
mesh_terms: D000818:Animals; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000032:analysis; D007194:India; D008297:Male; D059808:Polyphenols / Q000032:analysis; D017207:Rats, Sprague-Dawley; D020940:Reishi / Q000737:chemistry* / Q000302:isolation & purification; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D045424:Complex Mixtures; D005419:Flavonoids; D059808:Polyphenols