title: Th17 differentiation and their pro-inflammation function.
abstract: CD4(+) T helper cells are classical but constantly reinterpreted T-cell subset, playing critical roles in a diverse range of inflammatory responses or diseases. Depending on the cytokines they release and the immune responses they mediate, CD4(+) T cells are classically divided into two major cell populations: Th1 and Th2 cells. However, recent studies challenged this Th1/Th2 paradigm by discovering several T-helper cell subsets with specific differentiation program and functions, including Th17 cells, Treg cells, and Tfh cells. In this chapter, we summarize the current understanding and recent progresses on the Th17 lineage differentiation and its effector impacts on variety of inflammatory responses or disease pathogenesis.
authors.affiliation: The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences/Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
authors.forename: Xinyang
authors.initials: X
authors.lastname: Song
authors.forename: Hanchao
authors.initials: H
authors.lastname: Gao
authors.forename: Youcun
authors.initials: Y
authors.lastname: Qian
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D058570:TOR Serine-Threonine Kinases / Q000502:physiology; D058504:Th17 Cells / Q000166:cytology / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D016207:Cytokines; D014157:Transcription Factors; D058570:TOR Serine-Threonine Kinases