title: Multifunctional RNA nanoparticles.
abstract: Our recent advancements in RNA nanotechnology introduced novel nanoscaffolds (nanorings); however, the potential of their use for biomedical applications was never fully revealed. As presented here, besides functionalization with multiple different short interfering RNAs for combinatorial RNA interference (e.g., against multiple HIV-1 genes), nanorings also allow simultaneous embedment of assorted RNA aptamers, fluorescent dyes, proteins, as well as recently developed RNA-DNA hybrids aimed to conditionally activate multiple split functionalities inside cells.
authors.affiliation: Basic Research Laboratory, Center for Cancer Research, National Cancer Institute , Frederick, Maryland 21702, United States.
authors.forename: Kirill A
authors.initials: KA
authors.lastname: Afonin
authors.forename: Mathias
authors.initials: M
authors.lastname: Viard
authors.forename: Alexey Y
authors.initials: AY
authors.lastname: Koyfman
authors.forename: Angelica N
authors.initials: AN
authors.lastname: Martins
authors.forename: Wojciech K
authors.initials: WK
authors.lastname: Kasprzak
authors.forename: Martin
authors.initials: M
authors.lastname: Panigaj
authors.forename: Ravi
authors.initials: R
authors.lastname: Desai
authors.forename: Arti
authors.initials: A
authors.lastname: Santhanam
authors.forename: Wade W
authors.initials: WW
authors.lastname: Grabow
authors.forename: Luc
authors.initials: L
authors.lastname: Jaeger
authors.forename: Eliahu
authors.initials: E
authors.lastname: Heldman
authors.forename: Jakob
authors.initials: J
authors.lastname: Reiser
authors.forename: Wah
authors.initials: W
authors.lastname: Chiu
authors.forename: Eric O
authors.initials: EO
authors.lastname: Freed
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Shapiro
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D015316:Genetic Therapy; D015658:HIV Infections / Q000628:therapy / Q000821:virology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008819:Mice, Nude; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000235:genetics / Q000628:therapy; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D034741:RNA, Small Interfering
keywords: RNA interference; RNA nanoparticles; RNA nanotechnology; RNA−DNA hybrid reassociation; aptamers