title: Treatment of recurrent pregnancy loss by Levothyroxine in women with high Anti-TPO antibody.
abstract: BACKGROUND
  Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before twenty weeks of gestation. It is caused by a variety of genetics and non-genetics factors. Thyroid autoimmunity could associate with pregnancy loss.
  
  
  OBJECTIVE
  To investigate the effectiveness of Levothyroxine in treatment of RPL in women with high auto-thyroid antibodies.
  
  
  METHODS
  In this observational cross sectional study, 900 women who had a history of recurrent pregnancy loss were studied. All women with high anti-TPO antibody without any other problems entered in this study. Levothyroxine was given to them two months before pregnancy till the end of pregnancy. The doses of levothyroxine were depended on the anti-TPO levels, which were decided by endocrinologist. Women followed for the results of pregnancies.
  
  
  RESULTS
  The success rate of pregnancy in women with abnormal anti-TPO with Levothyroxine therapy was 82.85%. Mean of anti-TPO in women with treatment before taking medication was 488.35 and after that it was 123.35 UI/ml. This difference was significant (p<0.05). The mean of the antibodies was not significantly different in women without treatment.
  
  
  CONCLUSIONS
  This study showed that Levothyroxine reduces the incidence of spontaneous abortions in women with high Anti-TPO antibody. It decreased anti-TPO antibody levels after 2-3 months treatment.
authors.affiliation: Department of Pharmacology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Hosein
authors.initials: MH
authors.lastname: Mosaddegh
authors.affiliation: Department of Medical Genetics, Research and Clinical Centre for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Ghasemi
authors.affiliation: Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Jahaninejad
authors.affiliation: Yazd Azad University, Yazd, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Mohsenifar
authors.affiliation: Department of Obstetrics and Gynecology, Research and Clinical Centre for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Aflatoonian
keywords: Anti-TPO antibody; Levothyroxine; Recurrent pregnancy loss