title: The impact of the time interval on in-vitro fertilisation success after failure of the first attempt.
abstract: The aim of this study was to identify the optimal time interval for in-vitro fertilisation that would increase treatment success after failure of the first attempt. This retrospective study evaluated 454 consecutive cycles of 227 infertile women who had two consecutive attempts within a 6-month period at an IVF centre. Data were collected on duration of stimulation, consumption of gonadotropin, numbers of retrieved oocytes, mature oocytes, fertilised eggs, good quality embryos on day 3/5 following oocyte retrieval and clinical and ongoing pregnancy. There were significant increases in clinical pregnancy rates at 2-, 3- and 4-month intervals. The maximum increase was after two menstrual cycles (p = 0.001). The highest rate of ongoing pregnancy was in women that had the second attempt after the next menstrual cycle following failure of IVF (27.2%). After IVF failure, initiating the next attempt within 2-4 months increases the clinical pregnancy rates.
authors.affiliation: Department of Obstetrics and Gynecology, Recep Tayyip Erdoğan University, School of Medicine , Rize.
authors.forename: Y
authors.initials: Y
authors.lastname: Bayoglu Tekin
authors.forename: S T
authors.initials: ST
authors.lastname: Ceyhan
authors.forename: S
authors.initials: S
authors.lastname: Kilic
authors.forename: C
authors.initials: C
authors.lastname: Korkmaz
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects / Q000379:methods; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008597:Menstrual Cycle / Q000502:physiology; D054315:Oocyte Retrieval / Q000379:methods; D016471:Ovarian Hyperstimulation Syndrome / Q000378:metabolism / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D019233:Retreatment / Q000379:methods; D012189:Retrospective Studies; D061665:Time-to-Treatment; D017211:Treatment Failure; D014421:Turkey
chemical_list: D007987:Gonadotropin-Releasing Hormone
keywords: Attempt; GnRH antagonist; IVF failure; normoresponder; time interval