title: Peptides stimulate expression of signal molecules in neuronal cultures from animals of different age.
abstract: Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats. The effective concentration of peptide T-33 stimulating proliferative activity of neurons considerably surpassed that of cortexin. Cortexin and peptide T-33 stimulated the expression of serotonin, Ki-67, and vimentin in cells of the brain cortex; peptide T-33 was most effective in this respect.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: R S
authors.initials: RS
authors.lastname: Umnov
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010455:Peptides