title: [Respiratory system response to cooling in subjects with single nucleotide polymorphism rs11562975 in gene of thermosensitive TRPM8 ion channel].
abstract: On the basis of genomic studies in subjects belonged to Russian ethnic group it was identified individuals with heterozygous genotype, containing the C-allele in single nucleotide polymorphism rs11562975, located in 6 exon of the gene encoding the temperature-sensitive ion channel TRPM8. Subjects with heterozygous genotype GC were characterized by not only increased sensation to cold but also hypometabolic response to local skin cooling and non-temperature activation of TRPM8 ion channel by menthol--decrease in total metabolism, pulmonary ventilation and coefficient of oxygen extraction. The subjects with homozygous genotype GG had a lower cold sensation and adequate response to local skin cooling in respect to thermoregulation--decrease in respiratory heat loss and increase in the lipid metabolism.
authors.forename: T V
authors.initials: TV
authors.lastname: Kozyreva
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Tkachenko
authors.forename: T A
authors.initials: TA
authors.lastname: Potapova
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000328:Adult; D003080:Cold Temperature; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012143:Respiratory Physiological Phenomena / Q000235:genetics*; D050053:TRPM Cation Channels / Q000235:genetics*; D055815:Young Adult
chemical_list: D050053:TRPM Cation Channels; C425966:TRPM8 protein, human