title: A prospective, randomized multicenter study comparing conventional laparoscopic cholecystectomy versus minilaparotomy cholecystectomy with ultrasonic dissection as day surgery procedure--1-year outcome.
abstract: OBJECTIVE
  The long-term outcome between laparoscopic cholecystectomy (LC) and minilaparotomy cholecystectomy (MC) with ultrasonic dissection (UsD) technique has not been compared in randomized trials. Therefore, we investigated the outcome after conventional LC and MC with UsD in 78 patients (ClinicalTrials.gov Identifier: NCT0172340).
  
  
  METHODS
  Initially 88 patients with non-complicated symptomatic gallstone disease were randomized into MC (n = 44) or LC (n = 44) over a period of 2 years (2010-2012) and 78 of them (89%) were reached for a follow-up interview at 12 months after the surgery.
  
  
  RESULTS
  Baseline parameters were similar in the two groups, and 1/44 MCs and 2/44 LCs were converted to open laparotomy. The prevalence of chronic post-surgical pain (CPSP) one year after the procedure was quite similar in the two groups: 3/36 (8%) in the MC group and 2/42 (5%) in the LC group (p = 0.502). Residual abdominal symptoms were common, but the proportion was similar in both groups (28% in MC and 33% in LC group, p = 0.665). Both groups were very satisfied with the cosmetic outcome (numeric rating scale, p = 0.470). The Quality of life (QoL) improved 34/36 (94%) in the MC group and 33/42 (79%) in the LC group (p = 0.046) and all patients in both groups were satisfied with the operation overall.
  
  
  CONCLUSIONS
  Day-case MC and LC patients have a quite similar one-year outcome with no significant difference regarding residual abdominal symptoms, cosmetic satisfaction, QoL or CPSP.
authors.affiliation: School of Medicine, University of Eastern Finland , Kuopio , Finland.
authors.forename: Samuli
authors.initials: S
authors.lastname: Aspinen
authors.forename: Jukka
authors.initials: J
authors.lastname: Harju
authors.forename: Petri
authors.initials: P
authors.lastname: Juvonen
authors.forename: Hannu
authors.initials: H
authors.lastname: Kokki
authors.forename: Veikko
authors.initials: V
authors.lastname: Remes
authors.forename: Tom
authors.initials: T
authors.lastname: Scheinin
authors.forename: Matti
authors.initials: M
authors.lastname: Eskelinen
mesh_terms: D000328:Adult; D000368:Aged; D000556:Ambulatory Surgical Procedures / Q000379:methods*; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D002769:Cholelithiasis / Q000601:surgery*; D004210:Dissection / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007813:Laparotomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D059708:Ultrasonic Surgical Procedures / Q000379:methods*; D055815:Young Adult
keywords: cholecystectomy; day surgery; laparoscopy; minilaparotomy; randomized controlled trial; treatment outcome