title: [Idiopathic inflammatory myopathies: main clinical and immunological variants, difficulties of differential diagnostics and therapy].
abstract: Idiopathic inflammatory myopathies are rare autoimmune diseases with inflammatory lesions in skeletal muscles. They include polymyositis, dermatomyositis, juvenile myositis and inclusion body myositis. These are clinically and immunologically heterogeneous conditions differently responding to therapy. The authors consider the main manifestations of polymyositis/dermatomyositis and principal differences between them. Therapy is based on the prescription of glucocorticoids in combination with immunesuppressors. Better understanding immunological, genetic, and molecular mechanisms opens up new prospects for the management of idiopathic inflammatory myopathies.
authors.forename: O A
authors.initials: OA
authors.lastname: Antelava
authors.forename: E L
authors.initials: EL
authors.lastname: Nasonov
mesh_terms: D000940:Antigenic Variation / Q000276:immunology*; D003882:Dermatomyositis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000628:therapy; D009220:Myositis / Q000276:immunology* / Q000473:pathology* / Q000628:therapy; D017285:Polymyositis / Q000175:diagnosis / Q000473:pathology / Q000628:therapy