title: Post-treatment plasma omentin levels in patients with stage III colon carcinoma.
abstract: OBJECTIVE
  Gastrointestinal carcinomas are ~1.5-2-fold more prevalent in obese populations compared to nonobese ones. Possible factors playing an important role in the association between obesity and cancer include insulin, insulin like growth factor-I, sex steroids and adipocytokines. This study investigated the omentin levels, a novel adipocytokine, in patients with stage III colon carcinomas (CC).
  
  
  METHODS
  The study investigated 45 patients with stage III CC who had been treated with surgery and adjuvant oxaliplatin, leucovorin and 5-fluorouracil chemotherapy. The study control group was composed of 35 healthy individuals.
  
  
  RESULTS
  The median age of the CC and control groups was 62 (range 32-74) and 56 (range 43-71) years, respectively (p=0.206). There were no significant differences between the CC and control groups in terms of gender (p=0.218), body mass index (BMI) (p=0.218), fasting blood glucose (p=0.487), total cholesterol (TC) (p=0.521), low-density lipoprotein (LDL) (p=0.722), high-density lipoprotein (HDL) (p=0.078), triglycerides (TC) (p=0.698), hemoglobin (p=0.096) and creatinine levels (p=0.130). The median plasma omentin concentration was 618 pg/mL (range 151-758) in the CC group and 376 pg/mL (155-662) in the control group (p<0.001). No significant correlation was found between omentin and the other parameters examined in the CC group.
  
  
  CONCLUSIONS
  Omentin levels are significantly elevated in stage III CC patients treated with surgery and chemotherapy. This elevation was independent of the basic risk factors associated with elevated omentin levels. Future studies of the pathophysiological causes of omentin elevation may facilitate the evaluation of the interactions between CC and adipose tissue.
authors.affiliation: Department of Medical Oncology, Abant Izzet Baysal Medical Faculty, Bolu, Turkey.
authors.forename: Ummugul
authors.initials: U
authors.lastname: Uyeturk
authors.forename: Aytekin
authors.initials: A
authors.lastname: Alcelik
authors.forename: Gulali
authors.initials: G
authors.lastname: Aktas
authors.forename: Buket Kin
authors.initials: BK
authors.lastname: Tekce
mesh_terms: D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000097:blood* / Q000473:pathology / Q000628:therapy; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011446:Prospective Studies
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins