title: [Eenie, Meenie, Miney, Moe, who is responsible for the antibody-dependent enhancement of Aleutian mink disease parvovirus infection?].
abstract: Aleutian mink disease parvovirus (AMDV) causes a persistent infection associated with immune complex disease, hypergammaglobulinemia, and high levels of antiviral antibodies. Despite the presence of an antibody, the virus is not cleared in vivo. Pre-existing antibodies may enhance viral infections, by Fc-receptor-mediated antibody-dependent enhancement (ADE), but the mechanism that underlies ADE has not been fully defined. Three models have been proposed, including: (1) interactions between antibody and FcR, complement C3 fragment and CR, or between C1q and C1qR, which promotes viral attachment to cells; (2) suppression of IFN-gamma-mediated host-cell antiviral gene expression by the upregulation of negative regulators of pathogen pattern recognition; and (3) the promotion of early IL-10 secretion. In addition, the role of cytokine IL-6 in ADE mediated disease development is discussed, to facilitate a better understanding of the pathogenesis of AMDV infection, as well as give insights into rational vaccine design approaches.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhu
authors.forename: Xiu-Mei
authors.initials: XM
authors.lastname: Xing
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Wen
mesh_terms: D000453:Aleutian Mink Disease / Q000276:immunology / Q000821:virology*; D000454:Aleutian Mink Disease Virus / Q000235:genetics / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D019067:Antibody-Dependent Enhancement; D008907:Mink / Q000276:immunology / Q000821:virology
chemical_list: D000914:Antibodies, Viral