title: Di-tert-butyl peroxide-promoted α-alkylation of α-amino carbonyl compounds by simple alkanes.
abstract: A di-tert butyl peroxide (DTBP)-promoted α-alkylation of α-amino carbonyl compounds by simple alkanes is developed, proceeding through dual sp(3) C-H bonds cleavage. The reaction was applicable for α-amino ketones and α-amino esters, providing a facile pathway for the α-functionalization of these substrates. The radical pathway is involved in this transformation.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University , Changzhou 213164, People's Republic of China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Peng
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Yu
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry*
chemical_list: D000473:Alkanes; D000588:Amines; D010545:Peroxides; C111570:di-tert-butyl peroxide