title: Bioactive depsidones from the fungus Pilobolus heterosporus.
abstract: A new aromatic ester, pilobolusate (1), four new depsidones, pilobolusones A-D (2-5), five known depsidones, (6-10), and ergosterol were isolated from the fungus Pilobolus heterosporus. Their structures were established on the basis of spectroscopic data. Compounds 2 and 4-9 showed cytotoxicity against three cancer cell lines (KB, MCF-7, and NCI-H187) with IC50 values in the range of 9.94-97.42 µM. In addition, compounds 2, 5, 9, and 10 exhibited antimalarial activity against Plasmodium falciparum with IC50 values ranging from 3.67-23.56 µM.
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Oue-artorn
authors.initials: OA
authors.lastname: Rajachan
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Somdej
authors.initials: S
authors.lastname: Kanokmedhakul
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
authors.forename: Kwanjai
authors.initials: K
authors.lastname: Kanokmedhakul
authors.affiliation: Department of Plant Production Technology, Faculty of Agricultural Technology, King Mongkut's Institute of Technology Ladkrabang, Bangkok, Thailand.
authors.forename: Kasem
authors.initials: K
authors.lastname: Soytong
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002522:Chlorocebus aethiops; D053630:Depsides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D061986:MCF-7 Cells; D009090:Mucorales / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum; D014709:Vero Cells
chemical_list: D000962:Antimalarials; D053630:Depsides; D007783:Lactones; C000875:depsidone