title: High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review.
abstract: High dose of vitamin C intake could increase urine oxalate excretion and hence the risk of calcium stone formation. We report a case of left ureteral stone in a 9-year-old boy with an extremely high urine oxalate excretion. Besides, he had a habit of taking high-dose supplementation of vitamin C since the age of 3 years. After vitamin C intake prohibited without other therapy and change of dietary intake, the urine oxalate excretion was decreased to normal level and no recurrence of urolithiasis was present during the 3-year follow-up. Thus, high-dose supplementation with vitamin C for years in a child could induce the urinary stones.
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Xuehua
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Luming
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China. Electronic address: Urology_Gxj@163.com.
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Gu
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Dai
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Urology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D019587:Dietary Supplements; D006801:Humans; D008297:Male; D014514:Ureteral Calculi / Q000139:chemically induced*; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014815:Vitamins; D001205:Ascorbic Acid