title: Drugs that have been shown to cause drug-induced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007.
abstract: This review updates new findings in drug-induced immune- hemolytic anemia (DIIHA) since the 2007 review in Immunohematology by these authors. Twelve additional drugs have been added to the three tables listing drugs associated with drug-dependent antibodies, drugs associated with drug-independent antibodies, and drugs associated with nonimmunologic protein adsorption. Other updated findings include (1) piperacillin is currently the most commonly encountered cause of DIIHA, (2) new data on blood group specificity of drug-dependent antibodies, (3) drug-dependent antibodies detected in healthy donors, (4) DIIHA associated with transplantation, and(5) DIIHA associated with chemotherapeutic drugs.
authors.affiliation: PhD, FRCPath, Scientific Director.
authors.forename: George
authors.initials: G
authors.lastname: Garratty
authors.affiliation: MS, MT(ASCP)SBB (corresponding author), Senior Research Associate, American Red Cross Blood Services, Southern California Region, 100 Red Cross Circle, Pomona, CA 91768.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Arndt
mesh_terms: D000327:Adsorption; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced / Q000175:diagnosis / Q000266:history / Q000276:immunology*; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000936:Antigen-Antibody Complex / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D001798:Blood Proteins / Q000737:chemistry / Q000276:immunology; D002478:Cells, Cultured; D003298:Coombs Test; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D006461:Hemolysis / Q000276:immunology; D049674:History, 21st Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016377:Organ Transplantation; D010878:Piperacillin / Q000009:adverse effects
chemical_list: D000900:Anti-Bacterial Agents; D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D001798:Blood Proteins; D007166:Immunosuppressive Agents; D010878:Piperacillin