title: Association of increased S100A8 serum protein with early pregnancy loss.
abstract: OBJECTIVE
  The contribution of systemic S100A8 protein in menstrual cycle, pregnancy, and early pregnancy loss (EPL) is not known. Altered expression of S100A8 in maternal decidua is associated with recurrent early pregnancy loss. The objective of this study was to investigate the systemic level of S100A8 in different phases of menstrual cycle, different trimester of pregnancy, and in EPL.
  
  
  METHODS
  Level of S100A8 was investigated in serum samples of the subjects through enzyme-linked immunosorbent assay (ELISA).
  
  
  CONCLUSIONS
  S100A8 levels were elevated during proliferative phase of menstrual cycle. We found no statistical difference in S100A8 level in different trimester of pregnancy. S100A8 level was found to be significantly elevated in patients with EPL. This is the first study evaluating the systemic level of S100A8 predicting its role during menstrual cycle and pregnancy. It opens a new perspective in which S100A8 can be used as a prognostic marker for EPL.
authors.affiliation: Department of Molecular & Human Genetics, Banaras Hindu University, Varanasi, India.
authors.forename: Rohini R
authors.initials: RR
authors.lastname: Nair
authors.forename: Anuradha
authors.initials: A
authors.lastname: Khanna
authors.forename: Kiran
authors.initials: K
authors.lastname: Singh
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood*; D040501:Calgranulin A / Q000097:blood*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D011264:Pregnancy Trimesters / Q000097:blood
chemical_list: D040501:Calgranulin A
keywords: Early pregnancy loss; S100A8; inflammation; pregnancy; proliferative phase; secretory phase