title: Biomodulation effects of LED and therapeutic ultrasound combined with semipermeable dressing in the repair process of cutaneous lesions in rats.
abstract: OBJECTIVE
  To compare the biomodulatory effects of LED and ultrasound combined with semipermeable dressing in the repair of cutaneous lesions.
  
  
  METHODS
  Eighty-four Wistar rats were submitted to surgical injury (2.5 cm) and divided into four groups (n=21): Group I (control), Group II (LED therapy, LED), Group III (LED therapy + dressing, LED+D) and Group IV (ultrasound + dressing, US+D). At seven, 14 and 21 days, the animals were euthanized, and the specimens of interest removed for histological analysis.
  
  
  RESULTS
  Histological and histomorphometric analysis revealed a greater percent wound regression in animals receiving the dressing (group III: 55.97; group IV: 53.06), as well as a greater reduction in the inflammatory infiltrate (group III: 29.14; group IV: 31.71) since day 7. A later effect, with progression of the tissue repair process only after 14 and 21 days, was observed in the LED group intense fibroblast proliferation and greater collagen fiber production and organization were seen in the LED+D and US+D groups compared to the other groups.
  
  
  CONCLUSIONS
  LED combined with a dressing was more effective at accelerating in the repair of cutaneous lesions.
authors.affiliation: University of Vale do Paraiba, Sao Jose dos Campos, SP, Brazil.
authors.forename: Veruska Cronemberger
authors.initials: VC
authors.lastname: Nogueira
authors.affiliation: UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Nayana Pinheiro Machado de Freitas
authors.initials: NP
authors.lastname: Coelho
authors.affiliation: Integral Differential Faculty, Teresina, PI, Brazil.
authors.forename: Talvany Luis de
authors.initials: TL
authors.lastname: Barros
authors.affiliation: Center for Agricultural Sciences, Department Veterinary Clinic and Surgery, Federal University of Piaui, Teresina, PI, Brazil.
authors.forename: Silvana Maria Medeiros de Sousa
authors.initials: SM
authors.lastname: Silva
authors.affiliation: University Castelo Branco, Sao Jose dos Campos, SP, Brazil.
authors.forename: Marcelino
authors.initials: M
authors.lastname: Martins
authors.affiliation: Institute of Research and Development, UNIVAP, Sao Jose dos Campos, SP, Brazil.
authors.forename: Emilia Angela Loschiavo
authors.initials: EA
authors.lastname: Arisawa
mesh_terms: D000818:Animals; D001458:Bandages; D049109:Cell Proliferation / Q000528:radiation effects; D003094:Collagen / Q000032:analysis / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000379:methods; D003872:Dermatitis / Q000473:pathology / Q000628:therapy; D005347:Fibroblasts / Q000528:radiation effects; D008297:Male; D010789:Phototherapy / Q000379:methods*; D011897:Random Allocation; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012867:Skin / Q000293:injuries* / Q000473:pathology / Q000528:radiation effects; D013997:Time Factors; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003094:Collagen