title: AUTOMATED COLITIS DETECTION FROM ENDOSCOPIC BIOPSIES AS A TISSUE SCREENING TOOL IN DIAGNOSTIC PATHOLOGY.
abstract: We present a method for identifying colitis in colon biopsies as an extension of our framework for the automated identification of tissues in histology images. Histology is a critical tool in both clinical and research applications, yet even mundane histological analysis, such as the screening of colon biopsies, must be carried out by highly-trained pathologists at a high cost per hour, indicating a niche for potential automation. To this end, we build upon our previous work by extending the histopathology vocabulary (a set of features based on visual cues used by pathologists) with new features driven by the colitis application. We use the multiple-instance learning framework to allow our pixel-level classifier to learn from image-level training labels. The new system achieves accuracy comparable to state-of-the-art biological image classifiers with fewer and more intuitive features.
authors.affiliation: Dept. of BME and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA.
authors.forename: Michael T
authors.initials: MT
authors.lastname: McCann
authors.affiliation: Massachusetts Institute of Technology Lincoln Laboratory, Boston, MA, USA.
authors.forename: Ramamurthy
authors.initials: R
authors.lastname: Bhagavatula
authors.affiliation: Dept. of Mathematics and Statistics, Air Force Institute of Technology Wright-Patterson AFB, USA.
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Fickus
authors.affiliation: Dept. of Pathology, Children's Hospital of Pittsburgh University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Ozolek
authors.affiliation: Dept. of BME and Center for Bioimage Informatics, Carnegie Mellon University, Pittsburgh, PA, USA ; Dept. of ECE, Carnegie Mellon University, Pittsburgh, PA, USA.
authors.forename: Jelena
authors.initials: J
authors.lastname: Kovačević
keywords: colitis; histology; image classification