title: [Deep skin infection with Scedosporium apiospermum-infection in a renal transplant patient].
abstract: A 57-year-old immunosuppressed patient presented with multiple erythematous papules and pustules as well as isolated ulcerations on the right lower leg and subcutaneous nodules on the right thigh. The biopsy revealed granulomatous inflammation with numerous fungal hyphae, which were IDentified as Scedosporium apiospermum by PCR. He was treated with voriconazole 2 × 200 mg daily as well assurgical debridement. Scedosporium apiospermum is a rare pathogenic agent of deep mold fungus infections. Skin infections with Scedosporium apiospermum are underdiagnosed because of different clinical manifestations. In immunosuppressed patients, an infection represents a potentially life-threatening complication. Precise identification of the agent with introduction of antimycotic therapy appears to be pivotal to prevent fulminant disease.
authors.affiliation: Klinik für Dermatologie und Allergologie, Klinikum VEST GmbH, Behandlungszentrum Knappschaftskrankenhaus Recklinghausen, Dorstener Str. 151, 45657, Recklinghausen, Deutschland, Theresa.Strunk@Klinikum-Vest.de.
authors.forename: T
authors.initials: T
authors.lastname: Strunk
authors.forename: J-H
authors.initials: JH
authors.lastname: Blume
authors.forename: R-M
authors.initials: RM
authors.lastname: Szeimies
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy / Q000379:methods; D003646:Debridement; D003881:Dermatomycoses / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D021681:Scedosporium; D016896:Treatment Outcome; D065819:Voriconazole / Q000008:administration & dosage*
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole