title: Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8.
abstract: Androgen receptor (AR) is a validated target in all clinical states of prostate cancer. Androprostamines A and B, the new inhibitors of androgen receptor, were isolated from Streptomyces sp. MK932-CF8. Their structures were determined by the spectroscopic analysis, degradation studies and synthesis. Androprostamines showed potent inhibitory effect against androgen-dependent growth of human prostate cancer cells without cytotoxicity and repressed the androgen-induced expression of AR-regulated genes.
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
authors.forename: Yohko
authors.initials: Y
authors.lastname: Yamazaki
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Igarashi
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinoshita
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Hatano
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawada
authors.affiliation: Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Momose
authors.affiliation: 1] Institute of Microbial Chemistry (BIKAKEN), Numazu, Numazu-shi, Shizuoka, Japan [2] Institute of Microbial Chemistry (BIKAKEN), Tokyo, Shinagawa-ku, Tokyo, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Nomoto
mesh_terms: D059002:Androgen Receptor Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002934:Cinnamates / Q000302:isolation & purification / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D011944:Receptors, Androgen / Q000187:drug effects / Q000235:genetics; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D059002:Androgen Receptor Antagonists; D000970:Antineoplastic Agents; D002934:Cinnamates; D009842:Oligopeptides; D011944:Receptors, Androgen; C000599108:androprostamine A; C000599109:androprostamine B