title: [A case of metastatic salivary duct carcinoma successfully treated with trastuzumab-based targeted therapy].
abstract: Salivary duct carcinoma is a malignant salivary neoplasm with a poor prognosis. Effective treatment for remote metastases has not been recognized. We report herein on a case of this tumor overexpressing HER2 successfully treated with trastuzumab-based molecular targeted therapy. The patient was a 69-year-old man, who developed remote metastases into the liver and the thoracic vertebra six months after surgery and postoperative irradiation for the primary and nodal lesions. After targeted therapy including paclitaxel and trastuzumab, these metastatic lesions showed rapid and continued regression. After paclitaxel was discontinued due to peripheral neuropathy in the extremities, trastuzumab monotherapy followed without resulting in cardiotoxicity. After three years since development of remote metastases, the patient is doing well without re-progression of the disease.
authors.forename: Fukuichiro
authors.initials: F
authors.lastname: Iguchi
authors.forename: Zenchi
authors.initials: Z
authors.lastname: Taniguchi
authors.forename: Junko
authors.initials: J
authors.lastname: Kusano
authors.forename: Yuka
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Norihiko
authors.initials: N
authors.lastname: Murai
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D044584:Carcinoma, Ductal / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D017239:Paclitaxel / Q000008:administration & dosage; D018987:Salivary Ducts; D012468:Salivary Gland Neoplasms / Q000188:drug therapy* / Q000473:pathology; D000068878:Trastuzumab
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000068878:Trastuzumab; D017239:Paclitaxel