title: Usefulness of artificial endocrine pancreas during resection of insulinoma.
abstract: A 71-year-old woman had an episode of syncope due to hypoglycemia of 27 mg/dl. She was diagnosed with insulinoma and scheduled for laparoscopic enucleation along with the use of an artificial endocrine pancreas (STG-22, Nikkiso Co., Ltd., Tokyo, Japan). Anesthesia was maintained with sevoflurane and remifentanil. Her blood glucose level was controlled using the artificial endocrine pancreas, which enabled continuous blood glucose monitoring and computer-operated glucose and insulin infusion to maintain the blood glucose level at a steady state. The target concentration of blood glucose was set at 80-120 mg/dl during surgery. Until removal of the tumor, the blood glucose level was kept at around 80-100 mg/dl. After removal of the tumor, the blood glucose level gradually increased, but it was kept in the normal range by the artificial endocrine pancreas. The artificial endocrine pancreas was useful to monitor and maintain blood glucose levels during and after the removal of insulinoma, without any hyper- or hypoglycemia.
authors.affiliation: Department of Pharmacology, Institute of Health Biosciences, the University of Tokushima Graduate School.
authors.forename: Kayo
authors.initials: K
authors.lastname: Hirose
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawahito
authors.forename: Naoji
authors.initials: N
authors.lastname: Mita
authors.forename: Kazumi
authors.initials: K
authors.lastname: Takaishi
authors.forename: Tomiya
authors.initials: T
authors.lastname: Kawahara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Soga
authors.forename: Toshiko
authors.initials: T
authors.lastname: Katayama
authors.forename: Satoru
authors.initials: S
authors.lastname: Imura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Morine
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ikemoto
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Munehide
authors.initials: M
authors.lastname: Matsuhisa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kitahata
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D007340:Insulinoma / Q000601:surgery*; D010190:Pancreatic Neoplasms / Q000601:surgery*
chemical_list: D001786:Blood Glucose