title: Metal-catalyzed dealkoxylative C(aryl)-C(sp3) cross-coupling-replacement of aromatic methoxy groups of aryl ethers by employing a functionalized nucleophile.
abstract: The direct replacement of aromatic methoxy groups with activated carbon nucleophiles would give rise to novel synthetic pathways for targeted and diversity-oriented syntheses. We demonstrate here that this transformation can be achieved in a one-step reaction involving a bifunctional organolithium nucleophile in combination with a CAr OMe bond-cleaving nickel catalyst. The resulting products are stable, α-CH active, and suitable for various further modifications.
authors.affiliation: Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
authors.forename: Matthias
authors.initials: M
authors.lastname: Leiendecker
authors.forename: Chien-Chi
authors.initials: CC
authors.lastname: Hsiao
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Nurtalya
authors.initials: N
authors.lastname: Alandini
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
keywords: CO bond cleavage; aryl ethers; cross-coupling; methoxy functionalization; nickel