title: Effect of exercise therapy on muscle mass and physical functioning in patients undergoing allogeneic hematopoietic stem cell transplantation.
abstract: OBJECTIVE
  Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is associated with transplant-related toxicities, which may have a profound impact on a patient's physical functioning and body composition. In order to analyze the effect of exercise therapy on muscle mass and physical functioning in patients receiving allo-HSCT, we measured muscle mass and physical functioning before and after allo-HSCT.
  
  
  METHODS
  Eighty-six patients who had undergone allo-HSCT between February 2010 and September 2013 at Imamura Bun-in Hospital participated in this study. Physical therapists performed exercise therapy with patients 5 days a week, starting 2 weeks before allo-HSCT. Body composition, 6-min walk test (6MWT) scores, and handgrip strength were evaluated 2 weeks before allo-HSCT and 6 weeks after allo-HSCT.
  
  
  RESULTS
  Thirty-five patients were available for evaluation 2 weeks before and 6 weeks after allo-HSCT. The 6MWT (p = 0.005) and handgrip strength (p < 0.001) significantly decreased after allo-HSCT. Although upper extremity muscle mass (p = 0.001) and trunk muscle mass (p < 0.001) significantly decreased after allo-HSCT, lower extremity muscle mass remained unchanged.
  
  
  CONCLUSIONS
  In this study, it is suggested that exercise therapy may be effective for maintaining lower extremity muscle mass in patients undergoing allo-HSCT.
authors.affiliation: Department of Rehabilitation Medicine, Imamura Bun-in Hospital, 11-23 Kamoikeshinmachi, Kagoshima, 890-0064, Japan, soutakekiyo@yahoo.co.jp.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takekiyo
authors.forename: Koichiro
authors.initials: K
authors.lastname: Dozono
authors.forename: Takayuki
authors.initials: T
authors.lastname: Mitsuishi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Murayama
authors.forename: Ayako
authors.initials: A
authors.lastname: Maeda
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Nakano
authors.forename: Ayumu
authors.initials: A
authors.lastname: Kubota
authors.forename: Masahito
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Shogo
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Takatsuka
authors.forename: Atae
authors.initials: A
authors.lastname: Utsunomiya
mesh_terms: D000328:Adult; D001823:Body Composition; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D019337:Hematologic Neoplasms / Q000188:drug therapy / Q000534:rehabilitation*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D053580:Muscle Strength / Q000502:physiology*; D018908:Muscle Weakness / Q000517:prevention & control*; D009133:Muscular Atrophy / Q000517:prevention & control; D011788:Quality of Life; D055815:Young Adult