title: Computational vaccinology and epitope vaccine design by immunoinformatics.
abstract: Human immune system includes variety of different cells and molecules correlating with other body systems. These instances complicate the analysis of the system; particularly in postgenomic era by introducing more amount of data, the complexity is increased and necessity of using computational approaches to process and interpret them is more tangible.Immunoinformatics as a subset of bioinformatics is a new approach with variety of tools and databases that facilitate analysis of enormous amount of immunologic data obtained from experimental researches. In addition to directing the insight regarding experiment selections, it helps new thesis design which was not feasible with conventional methods due to the complexity of data. Considering this features immunoinformatics appears to be one of the fields that accelerate the immunological research progression.In this study we discuss advances in genomics and vaccine design and their relevance to the development of effective vaccines furthermore several division of this field and available tools in each item are introduced.
authors.affiliation: Tarbiat Modares University Department of Medical Biotechnology Tehran Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Khalili
authors.affiliation: Baqiyatallah University of Medical Sciences Applied Microbiology Research Center Tehran Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Jahangiri
authors.affiliation: Baqiyatallah Medical Science University Chemical Injuries Research Center Tehran Iran.
authors.forename: Hojat
authors.initials: H
authors.lastname: Borna
authors.affiliation: Shahed University Department of Biology, Faculty of Science Tehran Iran.
authors.forename: Kobra
authors.initials: K
authors.lastname: Ahmadi Zanoos
authors.affiliation: Baqiyatallah University of Medical Sciences Applied Microbiology Research Center Tehran Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Amani
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D015195:Drug Design; D000939:Epitopes / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D014612:Vaccines / Q000235:genetics* / Q000276:immunology*
chemical_list: D000939:Epitopes; D014612:Vaccines
keywords: immunoinformatics; immunology; new vaccine design