title: Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP.
authors.affiliation: Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Ming
authors.affiliation: 1] Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China [2] Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and School of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Ding
authors.affiliation: 1] Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China [2] Institute of Plant Stress Biology, State Key Laboratory of Cotton Biology, School of Life Sciences, Henan University, Kaifeng, Henan 475004, China.
authors.forename: Yuchao
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Zhejiang 310051, China.
authors.forename: Dazhi
authors.initials: D
authors.lastname: Jin
authors.affiliation: National Laboratory of Macromolecules, Institute of Biophysics, Chinese Academy of Science, Beijing 100101, China.
authors.forename: Yuna
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and School of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xia
authors.affiliation: Tsinghua-Peking Center for Life Sciences, Laboratory of Structural Biology, School of Medicine, Tsinghua University, Beijing, 100084, China.
authors.forename: Liming
authors.initials: L
authors.lastname: Yan
authors.affiliation: 1] Structural Biology Laboratory and MOE laboratory of Protein Science, School of Medicine and Life Science, Tsinghua University, Beijing 100084, China [2] Collaborative Innovation Center for Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610207 China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Lou
mesh_terms: D019943:Amino Acid Substitution; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D055162:Biocatalysis; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D009712:Nucleotides, Cyclic / Q000032:analysis / Q000378:metabolism; D009713:Nucleotidyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013379:Substrate Specificity; D014734:Vibrio cholerae / Q000201:enzymology*
chemical_list: D001426:Bacterial Proteins; D009712:Nucleotides, Cyclic; C584311:cyclic guanosine monophosphate-adenosine monophosphate; D009713:Nucleotidyltransferases