title: Involvement of NF-κB-dependent signaling and p38 MAPK signaling pathway in the regulation of hemopoiesis during restrain stress.
abstract: Protein kinase p38 was shown to contribute to the increase in production of granulocyte CSF by microenvironmental cells under conditions of restraint stress. Stimulation of colony-forming activity was not accompanied by the increase in maturation of clonogenic structures in the bone marrow granulocytic stem. This process was realized with the involvement of NF-κB-dependent signaling and p38 MAPK signaling pathway. Our study showed that the p38 MAPK signaling pathway plays an important role in the regulation of granulocytopoiesis, but not of erythropoiesis.
authors.affiliation: E. D. Goldberg Research Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia, mmu@pharm.tsu.ru.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuz'kov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskii
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: V I
authors.initials: VI
authors.lastname: Agafonov
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
mesh_terms: D000818:Animals; D006410:Hematopoiesis; D007103:Immobilization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016328:NF-kappa B / Q000378:metabolism*; D015398:Signal Transduction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D016328:NF-kappa B; D048051:p38 Mitogen-Activated Protein Kinases