title: Cadmium and nickel in blood of Tunisian population and risk of nasosinusal polyposis disease.
abstract: Nasosinusal polyposis (NSP) is a chronic inflammatory disease of the nasal mucosa. Although the pathophysiology underlying NSP formation is not fully understood, environmental factors appear to be contributed the development of this disease. A case-control study of Tunisian patients was examined to assess the levels of cadmium (Cd) and nickel (Ni) in blood and reparse the association between the exposure to these metals and the risk of nasosinusal polyposis disease. Mean blood levels of Cd in patients (2.2 ± 12.8 μg/L) were significantly higher than those of controls (0.5 ± 0.7 μg/L). Levels of blood Cd were positively correlated with tobacco smoking and chewing among controls. The Cd and Ni concentrations among control (p = 0.001) and patient (p = 0.018) tobacco consumers (smoking, chewing, and shisha) were significantly higher than those nonconsumers. Additionally, Ni blood levels of patient and control smokers were significantly higher than those of nonsmokers. Cd levels in blood samples of NSP patients occupationally exposed for more than 14 years were eight times higher than that of nonexposed. Drinking water was also found to be incriminated as exposure sources. Among risk factors, shisha consumption, environmental exposure, and occupational exposure presented the most significant association with NSP disease (odds ratio (OR) = 14.1, 10.1, and 1.7, respectively). High levels of blood Cd (OR = 3.5) were strongly associated with NSP disease (p = 0.027). Ni blood levels were shown to be associated with the four stages of polyps in both nasal cavities (right and left) (p < 0.05). This investigation suggested a potential role of toxic metals in the mechanism of NSP disease development. Exposure assessment investigations encompassing a wider population are needed.
authors.affiliation: Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia, rimkhlifi@yahoo.fr.
authors.forename: Rim
authors.initials: R
authors.lastname: Khlifi
authors.forename: Pablo
authors.initials: P
authors.lastname: Olmedo
authors.forename: Fernando
authors.initials: F
authors.lastname: Gil
authors.forename: Bouthaina
authors.initials: B
authors.lastname: Hammami
authors.forename: Amel
authors.initials: A
authors.lastname: Hamza-Chaffai
mesh_terms: D000328:Adult; D002104:Cadmium / Q000097:blood* / Q000633:toxicity; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D009532:Nickel / Q000097:blood* / Q000633:toxicity; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D016017:Odds Ratio; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014416:Tunisia / Q000453:epidemiology
chemical_list: D004785:Environmental Pollutants; D002104:Cadmium; D009532:Nickel