title: Effectiveness of an in-office arginine-calcium carbonate paste on dentine hypersensitivity in periodontitis patients: a double-blind, randomized controlled trial.
abstract: OBJECTIVE
  The aim of this single-centre, two-cell, double-blind, randomized controlled clinical study was to evaluate the effectiveness of an in-office desensitizing paste containing 8% arginine and calcium carbonate in providing relief on dentine hypersensitivity immediately after scaling and root planing and its sustained relief over a 6-week period.
  
  
  METHODS
  Fifty periodontitis subjects presenting hypersensitivity were subjected to scaling and root planing and in-office application of either 8% arginine and calcium carbonate desensitizing paste (25 subjects, test group) or fluoride-free prophylaxis paste (25 subjects, control group). Air-blast hypersensitivity was assessed using Schiff and Visual Analogue (VAS) scales at baseline, post-scaling, post-application, 2, 4 and 6 weeks.
  
  
  RESULTS
  At all evaluation times, the test group presented significant % reduction in hypersensitivity relative to post-scaling (t-test, p < 0.05) (Schiff - Test: 57, 58.6, 60.2, 68;
  
  
  METHODS
  28.6, 22.2, 23, 23) (VAS - Test: 60, 55.6, 60.1, 68.4;
  
  
  METHODS
  25.9, 18.2, 20.6, 22.7) and significant % hypersensitivity difference relative to control (ancova, p < 0.05) (Schiff: 38.9, 45.9, 47.4, 57.7; VAS: 49.1, 48.9, 52.6, 61).
  
  
  CONCLUSIONS
  The single in-office application of the 8% arginine-calcium carbonate desensitizing paste after scaling and root planing provided significant immediate reduction in dentine hypersensitivity, which sustained over a 6-week period.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Athens, Athens, Greece.
authors.forename: Eudoxie
authors.initials: E
authors.lastname: Pepelassi
authors.forename: Christos
authors.initials: C
authors.lastname: Rahiotis
authors.forename: Eleni
authors.initials: E
authors.lastname: Peponi
authors.forename: Afrodite
authors.initials: A
authors.lastname: Kakaboura
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vrotsos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001120:Arginine / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000627:therapeutic use*; D012534:Dental Scaling / Q000379:methods; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010518:Periodontitis / Q000628:therapy*; D016745:Root Planing / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*; D016896:Treatment Outcome; D064232:Visual Analog Scale; D055815:Young Adult
chemical_list: D057133:Dentin Desensitizing Agents; D014100:Toothpastes; D001120:Arginine; D002119:Calcium Carbonate
keywords: arginine; calcium carbonate; clinical trial; desensitizing paste; hypersensitivity; placebo; prophylaxis paste