title: Polymer brushes containing thermosensitive and functional groups grafted onto magnetic nano-particles for interaction and extraction of famotidine in biological samples.
abstract: This study introduces a new method for grafting poly[N-isopropylacrylamide-co-allyl glycidyl/iminodiacetic] onto iron oxide nano-particles modified using 3-mercaptopropyltrimethoxysilane. The grafted nano-polymer was characterized by Fourier transform infrared spectroscopy, elemental analysis, thermogravimetric analysis, transmission electron microscopy and scanning electron microscopy. The parameters of pH, contact time and temperature of the grafted nano-polymer were investigated. The determination and extraction of famotidine in human biological fluids was evaluated for high accessibility to active sites on the grafted sorbent. The equilibrium adsorption data were analyzed using the Langmuir and Freundlich models. The sorption capacity of the nano-sorbent was 116 mg g(-1) at an optimum pH of 7. About 73% of famotidine was released into simulated gastric fluid by 1 h and 70% was released into simulated intestinal fluids by 30 h at 37 °C. These results show that this new magnetic grafted nano-polymer is suitable for enteric drug delivery.
authors.affiliation: Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran. Electronic address: h.ahmadpanahi@iauctb.ac.ir.
authors.forename: Homayon
authors.initials: H
authors.lastname: Ahmad Panahi
authors.affiliation: Department of Chemistry, Islamic Azad University, Central Tehran Branch, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Nasrollahi
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004852:Epoxy Compounds / Q000737:chemistry; D015738:Famotidine / Q000008:administration & dosage* / Q000737:chemistry; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007098:Imino Acids / Q000737:chemistry; D058185:Magnetite Nanoparticles; D008956:Models, Chemical; D017646:Organosilicon Compounds; D011108:Polymers / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry; D013696:Temperature; D013997:Time Factors
chemical_list: D000180:Acrylic Resins; D004852:Epoxy Compounds; D006635:Histamine H2 Antagonists; D007098:Imino Acids; D058185:Magnetite Nanoparticles; D017646:Organosilicon Compounds; D011108:Polymers; D012821:Silanes; C052970:poly-N-isopropylacrylamide; D015738:Famotidine; C102833:(3-mercaptopropyl)trimethoxysilane; C054361:allyl glycidyl ether; C008109:iminodiacetic acid
keywords: Enteric drug delivery; Famotidine; Human biological fluids; Magnetic nano-particles; Solid phase extraction