title: A case of mental retardation with paraphilia treated with depot leuprorelin.
abstract: Paraphilia is a psychiatric disease that has been difficult to cure. However, recently developed therapeutic methods hold promise. The patient was a 20-yr-old male with chief complaints of continuous masturbation, genital exposure, and aggressive behavior that started 2 yr ago. We administered leuprorelin 3.6 mg intramuscular injection per month, a depot gonadotrophin-releasing hormone analogue, to this patient who a severe mentally retardation with paraphilia. The clinical global impression (CGI)-severity, CGI-improvement and aberrant behavior checklist were performed. After one month, we observed significant improvement in symptoms, such as decreases of abnormal sexual behavior and sexual desire. The GnRH analogues are suggested to be used as an alternative or supplementary therapeutic method for sexual offenders after clinical studies.
authors.affiliation: Department of Pediatrics, College of Medicine, Dankook University, Cheonan, Korea.
authors.forename: Woo Sung
authors.initials: WS
authors.lastname: Park
authors.affiliation: Department of Psychiatry, College of Medicine, Dankook University, Cheonan, Korea.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Kim
authors.affiliation: Department of Pharmacy, College of Pharmacy, Korea University, Sejong, Korea.
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Jung
authors.affiliation: Department of Psychology, College of Social Science, Dankook University, Cheonan, Korea.
authors.forename: Myung Ho
authors.identifier: 0000-0001-5370-4376
authors.initials: MH
authors.lastname: Lim
mesh_terms: D006801:Humans; D016729:Leuprolide / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010262:Paraphilic Disorders / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012742:Sex Offenses / Q000517:prevention & control; D012725:Sexual Behavior / Q000187:drug effects; D055815:Young Adult
chemical_list: D016729:Leuprolide
keywords: Leuprorelin; Mental Retardation; Paraphilias