title: Downregulation of MLL3 in esophageal squamous cell carcinoma is required for the growth and metastasis of cancer cells.
abstract: The mixed lineage leukemia 3 (MLL3), a member of the mixed lineage leukemia (MLL) family, has been reported to be mutated in multiple cancer types. However, its function in esophageal squamous cell carcinoma (ESCC) remains poorly understood. Here, we found that the expression of MLL3 was downregulated in ESCC tissues. Moreover, over-expression of MLL3 in ESCC cells inhibited cell proliferation and migration, while the knockdown expression of MLL3 promoted the tumorigenicity of ESCC cells. Mechanistically, MLL3 regulated the expression of multiple growth-related and migration-related genes. Taken together, our study suggested that downregulation of MLL3 was very important in the progression of ESCC.
authors.affiliation: Department of Thoracic Surgery, Jingjiang People's Hospital of Jiangsu Province, Jingjiang City, Jiangsu Province, 214500, China.
authors.forename: Manhui
authors.initials: M
authors.lastname: Xia
authors.forename: Lifang
authors.initials: L
authors.lastname: Xu
authors.forename: Yunhua
authors.initials: Y
authors.lastname: Leng
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Hong
authors.initials: H
authors.lastname: Xia
authors.forename: Diandian
authors.initials: D
authors.lastname: Zhang
authors.forename: Xuewu
authors.initials: X
authors.lastname: Ding
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009362:Neoplasm Metastasis; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology
chemical_list: D004268:DNA-Binding Proteins; C452979:KMT2C protein, human