title: Non-adherence to cardiovascular medications.
abstract: Despite evidence-based interventions, coronary heart disease (CHD) remains a leading cause of global mortality. As therapies advance, patient non-adherence to established treatments is well recognized. Non-adherence is a powerful confounder of evidence-based practice and can affect daily patient management, resulting in inappropriate therapeutic escalation with greater costs and potential for harm. Moreover, it increases risk for adverse cardiac events, including mortality. Yet, non-adherence is complex, remains difficult to define, and provider ability to identify its presence accurately remains limited. Improved screening tools are needed to detect at-risk patients, enabling appropriate targeting of interventions. Given the rapidly expanding global population with CHD and emerging clinical and cost-benefits of adherence, addressing non-adherence to prescribed therapies is a top priority.
authors.affiliation: Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bldg. E25-201, Cambridge, MA 02139, USA Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
authors.forename: Kumaran
authors.initials: K
authors.lastname: Kolandaivelu
authors.affiliation: Institute for Medical Engineering and Sciences, Massachusetts Institute of Technology, 77 Massachusetts Ave. Bldg. E25-201, Cambridge, MA 02139, USA.
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Leiden
authors.affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
authors.forename: Patrick T
authors.initials: PT
authors.lastname: O'Gara
authors.affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA dlbhattmd@post.harvard.edu.
authors.forename: Deepak L
authors.initials: DL
authors.lastname: Bhatt
mesh_terms: D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy* / Q000517:prevention & control*; D014943:Global Health / Q000706:statistics & numerical data; D006801:Humans; D010353:Patient Education as Topic; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D012307:Risk Factors; D016896:Treatment Outcome; D016903:Drug Monitoring
chemical_list: D002317:Cardiovascular Agents
keywords: Coronary heart disease; Non-adherence