title: Pharmacological evaluation of antihypertensive effect of aerial parts of Thymus linearis benth.
abstract: Traditionally Thymus linearis Benth. have been used for treatment of various diseases including hypertension. The present study was conducted to evaluate the hypotensive and antihypertensive effect of aqueous methanolic extract of aerial parts of Thymus linearis Benth. in normotensive and hypertensive rats. Acute and subchronic studies were also conducted. The aqueous methanolic extract produced a significant decrease in SBP, DBP, MBP and heart rate of both normotensive and hypertensive rats. LDv, of the extract was found to be 3000 mg/kg. The extract also exhibited a reduction in serum ALT, AST, ALP, cholesterol, triglycerides and LDL levels, while a significant increase in HDL level was observed. It is conceivable therefore, that Thymus linearis Benth. contains certain active compound(s) that are possibly responsible for the observed antihypertensive activity. Moreover, these findings further authenticate the traditional use of this plant in folklore medicine.
authors.lastname: Alamgeer
authors.forename: Muhammad Shoaib
authors.initials: MS
authors.lastname: Akhtar
authors.forename: Qaiser
authors.initials: Q
authors.lastname: Jabeen
authors.forename: Hafeez Ullah
authors.initials: HU
authors.lastname: Khan
authors.forename: Safirah
authors.initials: S
authors.lastname: Maheen
authors.lastname: Haroon-Ur-Rash
authors.forename: Sabeha
authors.initials: S
authors.lastname: Karim
authors.forename: Shahid
authors.initials: S
authors.lastname: Rasool
authors.forename: Muhammad Nasir Hayat
authors.initials: MN
authors.lastname: Malik
authors.forename: Kifayatullah
authors.initials: K
authors.lastname: Khan
authors.forename: Muhammad Naveed
authors.initials: MN
authors.lastname: Mushtaq
authors.forename: Fouzia
authors.initials: F
authors.lastname: Latif
authors.forename: Nazia
authors.initials: N
authors.lastname: Tabassum
authors.forename: Abdul Qayyum
authors.initials: AQ
authors.lastname: Khan
authors.forename: Haseeb
authors.initials: H
authors.lastname: Ahsan
authors.forename: Wasim
authors.initials: W
authors.lastname: Khan
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D046930:Thymus Plant
chemical_list: D000959:Antihypertensive Agents; D010936:Plant Extracts