title: Influence of cyclodextrin on the UCST- and LCST-behavior of poly(2-methacrylamido-caprolactam)-co-(N,N-dimethylacrylamide).
abstract: The monomer 2-methacrylamido-caprolactam (4) was synthesized from methacryloyl chloride (3) and racemic α-amino-ε-caprolactam (2). Copolymerization of 4 with N,N-dimethylacrylamide (5) was carried out by a free-radical mechanism using 2,2'-azobis(2-methylpropionitrile) (AIBN) as an initiator. The new copolymers show a lower critical solution temperature (LCST) in water and an upper critical solution temperature (UCST) in ethanol, 1-propanol, and 1-butanol. The solubility properties of the copolymers can be influenced significantly by the addition of randomly methylated β-cyclodextrin (CD). The complexation of the copolymers with CD, was confirmed by the use of ROESY-NMR-spectroscopy.
authors.affiliation: Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, D-40225 Duesseldorf. Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Burkhart
authors.affiliation: Institute of Organic Chemistry and Macromolecular Chemistry, Heinrich-Heine-University Duesseldorf, Universitaetsstrasse 1, D-40225 Duesseldorf. Germany.
authors.forename: Helmut
authors.initials: H
authors.lastname: Ritter
keywords: 2-methacrylamido-caprolactam; LCST; UCST; cyclodextrin; lysine