title: The association between lipid metabolism gene polymorphisms and nephropathy in type 2 diabetes: a meta-analysis.
abstract: OBJECTIVE
  Hyperlipidaemia has been identified as a risk factor for diabetic nephropathy via exacerbation of glomerular injury through the activation of multiple signaling pathways. This study's aim is to assess the associations between polymorphisms of genes involved in lipid metabolism, such as apolipoprotein E (ApoE), peroxisome proliferator-activated receptor γ (PPARγ), acetyl-CoA carboxylase β (ACACB), and type 2 diabetic nephropathy (T2DN).
  
  
  METHODS
  A search of the MEDLINE and Web of Science databases was used to identify relevant studies, and allele or genotype frequencies were pooled using fixed- or random-effects models.
  
  
  RESULTS
  Forty-five studies were included in this meta-analysis, consisting of 10,920 type 2 diabetic patients with nephropathy and 16,203 type 2 diabetic patients without nephropathy. The OR for ApoE ε2 versus ε3 was 1.49 (95% CI 1.13-1.95) in T2DN. The progression of T2DN was related to the presence of the ε2 allele and ε2 carrier with ORs of 1.72 (95% CI 1.10-2.69) and 1.78 (95% CI 1.18-2.69), respectively. The rs1801282 C>G variant in PPARγ presented a significant association with decreased T2DN risk, both in the G allele and GC/GG genotype with ORs of 0.77 (95% CI 0.68-0.87) and 0.79 (95% CI 0.69-0.92), respectively. The T allele in rs2268388 within ACACB showed an increased risk for T2DN, exhibiting an OR of 1.35 (95% CI 1.12-1.63).
  
  
  CONCLUSIONS
  Our meta-analysis supports that the ApoE ε2 allele and ACACB rs2268388 C>T might act as promotion factors of nephropathy in type 2 diabetes, whereas PPARγ rs1801282 C>G is a promising candidate genetic variation for reducing susceptibility to T2DN.
authors.affiliation: Department of Epidemiology and Biostatistics, Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.forename: Jieyun
authors.initials: J
authors.lastname: Yin
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
authors.forename: Shaofa
authors.initials: S
authors.lastname: Nie
authors.forename: Li
authors.initials: L
authors.lastname: Liu
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D003928:Diabetic Nephropathies / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D001057:Apolipoproteins E; D047495:PPAR gamma; C520105:ACACB protein, human; D000103:Acetyl-CoA Carboxylase