title: Histological correlates of N40 auditory evoked potentials in adult rats after neonatal ventral hippocampal lesion: animal model of schizophrenia.
abstract: The neonatal ventral hippocampal lesion (NVHL) is an established neurodevelopmental rat model of schizophrenia. Rats with NVHL exhibit several behavioral, molecular and physiological abnormalities that are similar to those found in schizophrenics. Schizophrenia is a severe psychiatric illness characterized by profound disturbances of mental functions including neurophysiological deficits in brain information processing. These deficits can be assessed by auditory evoked potentials (AEPs), where schizophrenics exhibit abnormalities in amplitude, duration and latency of such AEPs. The aim of the present study was to compare the density of cells in the temporal cerebral cortex and the N40-AEP of adult NVHL rats versus adult sham rats. We found that rats with NVHL exhibit significant lower amplitude of the N40-AEP and a significant lower number of cells in bilateral regions of the temporal cerebral cortex compared to sham rats. Because the AEP recordings were obtained from anesthetized rats, we suggest that NVHL leads to inappropriate innervation in thalamic-cortical pathways in the adult rat, leading to altered function of cortical networks involved in processing of primary auditory information.
authors.affiliation: Centro de Investigación en Reproducción Animal (CIRA), Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, CP 90070, México; Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México.
authors.forename: A L
authors.initials: AL
authors.lastname: Romero-Pimentel
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México.
authors.forename: R A
authors.initials: RA
authors.lastname: Vázquez-Roque
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México.
authors.forename: I
authors.initials: I
authors.lastname: Camacho-Abrego
authors.affiliation: Centro de Investigación en Reproducción Animal (CIRA), Universidad Autónoma de Tlaxcala-CINVESTAV, Tlaxcala, CP 90070, México.
authors.forename: K L
authors.initials: KL
authors.lastname: Hoffman
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México.
authors.forename: P
authors.initials: P
authors.lastname: Linares
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México. Electronic address: gonzalo.flores@correo.buap.mx.
authors.forename: G
authors.initials: G
authors.lastname: Flores
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Col. San Manuel, Puebla, Puebla, CP 72570, México. Electronic address: eliasmanjarrez@gmail.com.
authors.forename: E
authors.initials: E
authors.lastname: Manjarrez
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001303:Auditory Cortex / Q000166:cytology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006624:Hippocampus / Q000293:injuries; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000503:physiopathology*
keywords: Auditory Evoked Potentials; N40 wave; neonatal ventral hippocampus lesion; schizophrenia