title: Unusual presentations of melanoma: melanoma of unknown primary site, melanoma arising in childhood, and melanoma arising in the eye and on mucosal surfaces.
abstract: Most melanomas present as primary tumors on the skin surface in adults; however, melanomas also arise in the eye and on the mucosal surfaces or present as apparently metastatic disease without any known history of a cutaneous primary. Melanoma is also being diagnosed during childhood more frequently than ever. Surgeons need to be aware of and understand these unusual presentations of melanoma to optimally manage their patients.
authors.affiliation: Department of Cutaneous Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Oncologic Sciences, USF Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA; Department of Surgery, USF Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA. Electronic address: vernon.sondak@moffitt.org.
authors.forename: Vernon K
authors.initials: VK
authors.lastname: Sondak
authors.affiliation: Department of Cutaneous Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Anatomic Pathology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA; Department of Pathology & Cell Biology, USF Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA; Department of Dermatology, USF Morsani College of Medicine, 12901 Bruce B. Downs Boulevard, Tampa, FL 33612, USA.
authors.forename: Jane L
authors.initials: JL
authors.lastname: Messina
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy / Q000379:methods; D020405:Dermis / Q000473:pathology; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D007223:Infant; D008207:Lymphatic Metastasis; D008487:Medical History Taking; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D009092:Mucous Membrane / Q000473:pathology; D009382:Neoplasms, Unknown Primary / Q000473:pathology* / Q000601:surgery; D010808:Physical Examination; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery; D014781:Viscera / Q000473:pathology
keywords: Adjuvant therapy; Immunotherapy; Melanoma; Mucosal melanoma; Pediatric melanoma; Targeted therapy; Unknown primary; Uveal melanoma