title: Relationship between mean platelet volume and morning blood pressure surge in newly diagnosed hypertensive patients.
abstract: OBJECTIVE
  Morning blood pressure surge (MBPS) is an independent predictor of atherothrombotic cardiovascular events in hypertensive patients. There is evidence from studies supporting the validity of mean platelet volume (MPV) as a marker of vascular risk and predictor of thrombotic complications. The aim of this study is to investigate the relationship between MPV and MBPS in hypertensive patients.
  
  
  METHODS
  Measurements were obtained from 298 patients with newly diagnosed essential hypertension (Mean age: 51.9 ± 11.7 years). The patients were divided into two groups (MPV(low) group; <10.8 fL, MPV(high) group; ≥ 10.8 fL). The MBPS was calculated as mean systolic BP during the 2 hours after awaking minus the mean systolic BP during the 1 hour that included the lowest sleep BP.
  
  
  RESULTS
  MPV was independently associated with MBPS (β=0.554, p<0.001) and hs-CRP level (β=0.286, p<0.001).
  
  
  CONCLUSIONS
  Finally, higher MPV values related to enhanced MBPS which are associated with atherothrombotic cardiovascular events.
authors.affiliation: Clinic of Cardiology, Adana Numune Training and Research Hospital; Adana-Turkey. ucarhakan2005@gmail.com.
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Mehmet Yavuz
authors.initials: MY
authors.lastname: Gözükara
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kolcu
authors.forename: Selehattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypaklı
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Şahin
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D002097:C-Reactive Protein; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D011446:Prospective Studies; D020521:Stroke / Q000503:physiopathology*
chemical_list: D002097:C-Reactive Protein