title: New Molecules in Babesia gibsoni and their application for diagnosis, vaccine development, and drug discovery.
abstract: Babesia gibsoni is an intraerythrocytic apicomplexan parasite that causes piroplasmosis in dogs. B. gibsoni infection is characterized clinically by fever, regenerative anemia, splenomegaly, and sometimes death. Since no vaccine is available, rapid and accurate diagnosis and prompt treatment of infected animals are required to control this disease. Over the past decade, several candidate molecules have been identified using biomolecular techniques in the authors' laboratory for the development of a serodiagnostic method, vaccine, and drug for B. gibsoni. This review article describes newly identified candidate molecules and their applications for diagnosis, vaccine production, and drug development of B. gibsoni.
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan. ; Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors.forename: Youn-Kyoung
authors.initials: YK
authors.lastname: Goo
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido 080-8555, Japan.
authors.forename: Xuenan
authors.initials: X
authors.lastname: Xuan
mesh_terms: D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D000981:Antiprotozoal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001403:Babesia / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification*; D001404:Babesiosis / Q000175:diagnosis* / Q000188:drug therapy / Q000517:prevention & control; D004285:Dogs; D055808:Drug Discovery / Q000379:methods; D016052:Protozoan Vaccines / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D000981:Antiprotozoal Agents; D016052:Protozoan Vaccines
keywords: Babesia gibsoni; drug; serodiagnosis; vaccine