title: Oral administration of royal jelly restores tear secretion capacity in rat blink-suppressed dry eye model by modulating lacrimal gland function.
abstract: Tears are secreted from the lacrimal gland (LG), a dysfunction in which induces dry eye, resulting in ocular discomfort and visual impairment. Honey bee products are used as a nutritional source in daily life and medicine; however, little is known about their effects on dry eye. The aim of the present study was to investigate the effects of honey bee products on tear secretion capacity in dry eye. We selected raw honey, propolis, royal jelly (RJ), pollen, or larva from commercially available honey bee products. Tear secretion capacity was evaluated following the oral administration of each honey bee product in a rat blink-suppressed dry eye model. Changes in tear secretion, LG ATP content, and LG mitochondrial levels were measured. RJ restored the tear secretion capacity and decrease in LG ATP content and mitochondrial levels to the largest extent. Royal jelly can be used as a preventative intervention for dry eye by managing tear secretion capacity in the LG.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Imada
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakamura
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kitamura
authors.affiliation: Department of Veterinary Physiology, Faculty of Agriculture, Tottori University, Tottori, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Shibuya
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tsubota
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001767:Blinking; D004195:Disease Models, Animal; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D005227:Fatty Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D006722:Honey; D007765:Lacrimal Apparatus / Q000187:drug effects* / Q000503:physiopathology; D011429:Propolis / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D013666:Tears / Q000378:metabolism*; D000099219:Royal Jelly
chemical_list: D005227:Fatty Acids; D011429:Propolis; D000099219:Royal Jelly