title: Interleukin-17 in human inflammatory diseases.
abstract: Human Th17 pro-inflammatory cells are currently defined as cells that produce IL-17A and F, tumor necrosis factor (TNF)-α, IL-6, IL-21, IL-22 and IL-23. Recently discovered related molecules are forming a family of cytokines, the IL-17 family, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The associated receptors for the IL-17 family identified are IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. This review introduces the roles of IL-17 and Th17 cells in human autoimmune diseases. Studies have shown that T cells with inflammatory effects on epithelial, endothelial and fibroblast cells express IL-17. Th17 cells are supposed to be involved in various autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel diseases. Base on the biologic functions and regulation, IL-17 has regulatory roles in host defense and chronic inflammation which result in tissue damage and autoimmunity. So the IL-17 links links innate and adaptive immunity and has both beneficial and pathological effects on the immune system. This paper will focus on the possible roles of IL-17 in autoimmune diseases, a fundamental player in immune regulation.
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Head of Department: Prof. Abbas Mirshafiey.
authors.forename: Arezoo Gowhari
authors.initials: AG
authors.lastname: Shabgah
authors.affiliation: Department of Immunology, Tabriz University of Medical Sciences, Tabriz, Iran. Head of Department: Dr. Jafar Majidi.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Fattahi
authors.affiliation: Multiphase Chemistry Departments, Max Planck Institute for Chemistry, Mainz, Germany. Head of Department: Prof. Dr. Detlef Schuppan ; Division of Translational Immunology, Department of Medicine I, University Medical Center, Johannes Gutenberg University, Mainz, Germany. Head of Department: Prof. Dr. Ulrich Pöschl.
authors.forename: Fatemeh Zare
authors.initials: FZ
authors.lastname: Shahneh
keywords: T cells; autoimmunity; cytokine receptors; cytokines; inflammation; interleukin-17