title: X-ray-induced expression changes of TNFSF4 gene in human peripheral blood.
abstract: This study examined ionizing radiation-induced tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) mRNA expression changes in human peripheral blood cells and their distribution in a normal population. The results showed that expression level of TNFSF4 mRNA exhibited a dose-dependent response after different irradiation doses, but that was independent of incubation time post-irradiation. Moreover, it was not affected by age and gender in 51 healthy donors. Our studies indicate that TNFSF4 can be considered as a candidate gene to develop a new biodosimeter.
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Shi En
authors.initials: SE
authors.lastname: Li
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Guo
authors.affiliation: Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.affiliation: Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Han
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
authors.forename: Xi Ai
authors.initials: XA
authors.lastname: Wang
authors.affiliation: Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China;Henan Institute of Occupational Medicine, Zhengzhou 450052, Henan, China.
authors.forename: Yu Min
authors.initials: YM
authors.lastname: Lyu
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001773:Blood Cells / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000097:blood*; D014965:X-Rays; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053278:OX40 Ligand; C089251:TNFSF4 protein, human