title: A metal-free one-pot cascade synthesis of highly functionalized biaryl-2-carbaldehydes.
abstract: A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis of polyfunctional biaryl-2-carbaldehydes. The reaction proceeds at room temperature by a trifluoroacetic acid mediated Diels-Alder pathway. Synthetic applications of the resulting biaryl-2-carbaldehyde have been demonstrated by conversion into an array of diverse molecules with biological and materials chemistry relevance. The present work offers a complementary route to the existing metal mediated cross-coupling methods for the preparation of biaryls.
authors.affiliation: Academy of Scientific and Innovative Research (AcSIR), New Delhi 110001, India. ravishankar@niist.res.in.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Challa
authors.forename: Jamsheena
authors.initials: J
authors.lastname: Vellekkatt
authors.forename: Jaice
authors.initials: J
authors.lastname: Ravindran
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Lankalapalli
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D061565:Cycloaddition Reaction; D015394:Molecular Structure; D013696:Temperature; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D003300:Copper; D014269:Trifluoroacetic Acid