title: [The impact of obesity on renal function at one year after kidney transplantation: single-center experience].
abstract: BACKGROUND
  Kidney transplantation is the treatment of choice for ESRD. Several studies have investigated the factors that may affect kidney function at 1 year. The factors mentioned are anemia, hypercholesterolemia, immunosuppressors, etc. We studied the independent predictors of serum creatinine>100μmol/L at 1 year.
  
  
  METHODS
  We conducted a retrospective study from March 1999 to December 2009. We conducted a chart review of 402 kidney transplant patients. The kidneys were removed from cadaveric donors. Data collected included age, weight, height, preoperative BMI, the causal nephropathy, smoking, hypertension, diabetes, anticoagulation. Intraoperative data included operative time, and cold ischemia. Statistical analysis consisted of a t-test for independent samples comparing the group with a creatinine≤100μmol/L vs>100 group, and univariate and multivariate Cox regression for a serum creatinine>100μmol/L at 1 year and test of correlation between BMI and serum creatinine at 1 year postoperatively.
  
  
  RESULTS
  We found a significant difference in BMI and cold ischemia with P=0.008 and P=0.002, respectively. In contrast there was no difference in age, operative time and blood loss, P=0.758, P=0.941 and P=0.963, respectively. Multivariate Cox regression showed that donor age P=0.004 (HR: 1.016 and CI: 1.005-1.027), a recipient age P=0.023 (HR: 0.986 and CI: 0.974-0.998) and BMI P=0.001 (HR: 1.019 and CI: 1.010-1.028) were independent predictors of serum creatinine>100μmol/L at 1 year. The Pearson correlation coefficient r=0.154 (P=0.004) showed a significant correlation between BMI and serum creatinine.
  
  
  CONCLUSIONS
  Our study showed that donor age, recipient age and BMI were independent predictors of renal function>100μmol/L at 1 year. Our results highlight the difficulty of the management of obesity in renal transplant patients.
  
  
  METHODS
  5.
authors.affiliation: Service d'urologie, hôpital du Val-de-Grace, 74, boulevard du Port-Royal, 75230 Paris cedex 05, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Bayoud
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France. Electronic address: lisegant@hotmail.com.
authors.forename: M L
authors.initials: ML
authors.lastname: Kamdoum Nanfack
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: C
authors.initials: C
authors.lastname: Marchand
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: S
authors.initials: S
authors.lastname: Kozal
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: I
authors.initials: I
authors.lastname: Cholley
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: P
authors.initials: P
authors.lastname: Leon
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: R
authors.initials: R
authors.lastname: Fournier
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: T
authors.initials: T
authors.lastname: Lassere
authors.affiliation: Service d'urologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51100 Reims, France.
authors.forename: S
authors.initials: S
authors.lastname: Larre
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Créatininémie; Fonction rénale; Kidney function; Kidney transplantation; Serum creatinine; Transplantation rénale