title: Selective perfluoro- and polyfluoroarylation of Meldrum's acid.
abstract: This work describes the facile and mono-selective per- and polyfluoroarylation of Meldrum's acid to generate a versatile synthon for highly fluorinated α-phenyl acetic acid derivatives, which provide straightforward access to fluorinated building blocks. The reaction takes place quickly, and most products were isolated without the need for chromatography. Importantly, this method provides an alternative strategy to access α-arylated Meldrum's acids, which avoids the need for aryl-Pb(IV) salts or diaryliodonium salts. Furthermore, we demonstrate the synthetic versatility and utility of the Meldrum's acid products by subjecting our products to several derivatizations of the Meldrum's acid products as well as photocatalytic hydrodefluorination.
authors.affiliation: Department of Chemistry, Oklahoma State University , 107 Physical Science, Stillwater, Oklahoma 74078, United States.
authors.forename: Sameera M
authors.initials: SM
authors.lastname: Senaweera
authors.forename: Jimmie D
authors.initials: JD
authors.lastname: Weaver
mesh_terms: D004146:Dioxanes / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007854:Lead / Q000737:chemistry; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry; D055668:Photochemical Processes
chemical_list: D004146:Dioxanes; D006845:Hydrocarbons, Fluorinated; D009861:Onium Compounds; D007854:Lead; C076489:Meldrum's acid