title: [Study of the relationship between arousal parameters and daytime sleepiness in patients with obstructive sleep apnea syndrome].
abstract: OBJECTIVE
  To explore the effect of arousal parameters on excessive daytime sleepiness(EDS) in patients with obstructive sleep apnea syndrome(OSAS).
  
  
  METHODS
  A total of 205 patients who underwent polysomnography (PSG) from June 2012 to September 2013 in our hospital were enrolled. They were divided into 3 groups:85 patients in the OSAS sleepiness group (AHI ≥ 5/h, ESS ≥ 9), 86 patients in the OSAS non-sleepiness group (AHI ≥ 5/h, ESS<9), and 34 healthy subjects in the control group (AHI<5 times/h, ESS<9). Patient characteristics and PSG parameters of the 3 groups were analyzed.
  
  
  RESULTS
  The difference of age, BMI, ESS, N1+ N2%, N3%, AHI, oxygen desaturation index (ODI), mean oxygen saturation (MSaO₂), lowest oxygen saturation (LSaO₂), oxygen below 90% of the time (T90%), total arousal index (ARtotI), respiratory arousal index/ARtotI (RAI/ARtotI), spontaneous arousal index/ARtotI (SAI/ARtotI), sleep pressure score (SPS) were statistically different among the 3 groups (P < 0.05). But except for REM% [(15 ± 5)%, (16 ± 6)%, (17 ± 7)%, P > 0.05], the difference of age and BMI between OSAS sleepiness group and OSAS non-sleepiness group were not significant (P > 0.016 7), but the difference of other indices between any 2 groups were significant (P < 0.016 7). ARtotI and SPS were positively correlated with ESS (r = 0.383 and 0.244, P < 0.001). Logistic regression analysis showed that only awakening and SPS were the risk factors for OSAS [OR = 1.070 (95% CI: 1.038 - 1.102) and 0.158 (95% CI: 0.026 - 0.984), respectively].
  
  
  CONCLUSIONS
  Arousal at night is closely associated with EDS in OSAS. ARtotI and SPS can be evaluated as an objective indicator of EDS in OSAS patients.
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Kang
authors.initials: K
authors.lastname: Wu
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Jiangjie
authors.initials: J
authors.lastname: Sun
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Xinjuan
authors.initials: X
authors.lastname: Tan
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Guihua
authors.initials: G
authors.lastname: Li
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Xiaofen
authors.initials: X
authors.lastname: Su
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China.
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: The First Affiliated Hospital of Guangzhou Medical University,Guangzhou Institute of Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou 510120, China. Email: nfzhanggird@163.com.
authors.forename: Nuofu
authors.initials: N
authors.lastname: Zhang
mesh_terms: D001143:Arousal; D016022:Case-Control Studies; D006801:Humans; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*; D012894:Sleep Stages
chemical_list: D010100:Oxygen