title: Coenzyme q10 abrogated the 28 days aluminium chloride induced oxidative changes in rat cerebral cortex.
abstract: OBJECTIVE
  The present study was designed to elucidate the impact of oral administration of aluminium chloride for 28 days with respect to oxidative stress in the cerebral cortex of female rats. Further, to investigate the potentials of Coenzyme (Co) Q10 (4, 8, and 12 mg/kg, i.p.) in mitigating the detrimental changes.
  
  
  METHODS
  Biochemical estimations of cerebral lipid peroxidation (LPO), reduced glutathione (GSH), vitamin E and activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were carried out after 28 days of aluminium chloride (AlCl3) and Co Q10 exposures along with histopathological examination of cerebral cortex of the rats.
  
  
  RESULTS
  Subacute exposure to AlCl3(5 mg/kg) led to significant decrease in levels of GSH, vitamin E and activities of SOD, CAT, GPx, and an increase in LPO of cerebral cortex. These aberrations were restored by Co Q10 (12 mg/kg, i.p.). This protection offered was comparable to that of L-deprenyl (1 mg/kg, i.p.) which served as a reference standard. Histopathological evaluations confirmed that the normal cerebral morphology was maintained by Co Q10.
  
  
  CONCLUSIONS
  Thus, AlCl3 exposure hampers the activities of various antioxidant enzymes and induces oxidative stress in cerebral cortex of female Wistar rats. Supplementation with intraperitoneal Co Q10 abrogated these deleterious effects of AlCl3.
authors.affiliation: Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, Maharashtra, India.
authors.forename: Anuradha S
authors.initials: AS
authors.lastname: Majumdar
authors.affiliation: Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, Maharashtra, India.
authors.forename: Abhijit
authors.initials: A
authors.lastname: Nirwane
authors.affiliation: Department of Pharmacology, Bombay College of Pharmacy, Kalina, Mumbai, Maharashtra, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kamble
keywords: Aluminium chloride; L-deprenyl; coenzyme Q10; neurotoxicity; oxidative stress