title: Multifunctional nanomesoporous materials with upconversion (in vivo) and downconversion (in vitro) luminescence imaging based on mesoporous capping UCNPs and linking lanthanide complexes.
abstract: A series of new multifunctional nanomesoporous materials based on upconversion nanophosphors NaYF4:Yb,Tm@NaGdF4 (UCNPs) and lanthanide complexes were designed and synthesized through mesoporous capping UCNPs nanophosphors and linking lanthanide (Ln) complexes. The obtained UCNPs@mSiO2-Ln(dbm)4 (Ln = Eu, Sm, Er, Nd, Yb) materials can achieve downconversion and upconversion luminescence to show multicolor emission (covering the spectral region from 450 nm to 1700 nm) under visible-light excitation and 980 nm excitation, respectively. In addition, low cytotoxicity and good biocompatibility was found as determined by methyl thiazolyl tetrazolium assay, and the nanomesoporous materials were successfully applied to cell imaging in vitro based on Eu(3+) luminescence (under 405 nm excitation) and small animal imaging based on Tm(3+) luminescence (under 980 nm excitation). The doped Gd(3+) ion endows the nanomesoporous materials UCNPs@mSiO2-Ln(dbm)4 with effective T1 signal enhancement, which affords them as potential magnetic resonance imaging (MRI) contrast agents. Therefore, our results may provide more exciting opportunities for multimodal bioimaging and multifunctional applications.
authors.affiliation: Research Center of Nano Science and Technology, Shanghai University, Shanghai 200444, P. R. China. lnsun@shu.edu.cn shiliyi@shu.edu.cn.
authors.forename: Lining
authors.initials: L
authors.lastname: Sun
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Ge
authors.forename: Jinliang
authors.initials: J
authors.lastname: Liu
authors.forename: Yannan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Zuwu
authors.initials: Z
authors.lastname: Wei
authors.forename: Bo
authors.initials: B
authors.lastname: Tian
authors.forename: Liyi
authors.initials: L
authors.lastname: Shi
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry; D005063:Europium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D007834:Lasers; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D008422:Materials Testing; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010758:Phosphorus / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted; D012825:Silicon / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003287:Contrast Media; D028581:Lanthanoid Series Elements; D010758:Phosphorus; D005063:Europium; D012825:Silicon