title: Blood typing profile of a school-aged population of a North Togo township.
abstract: The aim of this study was the determination of hemoglobin (Hb) variants and ABO blood groups in a school population aged 6 to 9 years in the township of Agbandé-Yaka in North Togo. A cross-sectional study was carried out on 570 children of four primary schools at Agbande-Yaka, between March and July 2010. Hemoglobin characterization was done by alkaline buffer electrophoresis and the blood types ABO-Rhesus (Rh) D by immuno-hematological methods. A Hb variant was detected in 37.0% of the schoolchildren. Among them, the AS trait accounted for 11.9% and the AC trait for 20.2%. Homozygous Hb S (HBB: c.20A>T) was not found but Hb C (HBB: c.19G>A) appeared at a frequency of 3.3%, while compound heterozygotes carrying Hb SC were seen at a frequency of 1.6%. The O, B and A blood groups accounted for 49.0, 26.8 and 21.9%, respectively. The Hb anomalies reached a high prevalence in this school population. These results are remarkable by the absence of homozygous Hb S individuals compared to homozygous Hb C individuals, which were as numerous as expected. The frequencies of the ABO blood groups are similar to what has been found in other West African populations.
authors.affiliation: Laboratory Hematology the CHU-Sylvanus Olympio , Lomé , Togo .
authors.forename: Ahoefa
authors.initials: A
authors.lastname: Vovor
authors.forename: Lochina
authors.initials: L
authors.lastname: Fétéké
authors.forename: Irénée M
authors.initials: IM
authors.lastname: Kueviakoe
authors.forename: Laye
authors.initials: L
authors.lastname: Kpatarou
authors.forename: Koffi
authors.initials: K
authors.lastname: Mawussi
authors.forename: Hézouwè
authors.initials: H
authors.lastname: Magnang
authors.forename: Akuété Y
authors.initials: AY
authors.lastname: Ségbéna
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood*; D000483:Alleles; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D006444:Hemoglobin C / Q000032:analysis* / Q000235:genetics; D006445:Hemoglobin C Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D006450:Hemoglobin SC Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000032:analysis* / Q000235:genetics; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008403:Mass Screening; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D012204:Rh-Hr Blood-Group System / Q000097:blood*; D012574:Schools; D014037:Togo / Q000453:epidemiology
chemical_list: D000017:ABO Blood-Group System; D006451:Hemoglobin, Sickle; D012204:Rh-Hr Blood-Group System; D006444:Hemoglobin C
keywords: Blood groups; hemoglobin (Hb); school children; sickle cell anemia; togo