title: Curative effect research on curing intercostal neuralgia through paravertebral nerve block combined with pregabalin.
abstract: This paper aimed to discuss the curative effect and safety of curing intercostal neuralgia through paravertebral nerve block combined with pregabalin. 90 cases of patients diagnosed as intercostal neuralgia were taken as research object. Random number method was used to divide the patients that is conforming to the inclusion criteria and exclusion criteria into 3 groups. 30 cases was in group A (oral lyrica), 30 cases was in group B (paravertebral block only) and 30 cases was in group C (paravertebral block combined with pregabalin). The clinical effect and safety of three groups was compared. The result showed that: visual analogue scale (VAS) and quality of sleep (QS) of three groups of patients after treatment all decreased obviously; group A had slow work, large amount of dosage and many adverse effects; group B had quick work, but the improvement on pain and sleep was not satisfactory; the curative effect of group C was higher than group A and B (p<0.05); 3 groups all had adverse effect, among which group C had the least adverse effect. It can be concluded that paravertebral nerve block combined with pregabalin for curing intercostal neuralgia was superior than single use of pregabalin or paravertebral block and that is worth to promote.
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xiao
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital, Zhengzhou University,Zhengzhou, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Zhu
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital, Zhengzhou University,Zhengzhou, China.
authors.forename: Xuejian
authors.initials: X
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D009437:Neuralgia / Q000628:therapy*; D000069583:Pregabalin; D012890:Sleep; D064232:Visual Analog Scale; D005680:gamma-Aminobutyric Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid