title: Esterase-activated release of naproxen from supramolecular nanofibres.
abstract: Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.
authors.affiliation: Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL 60611, USA. s-stupp@northwestern.edu.
authors.forename: Martin
authors.initials: M
authors.lastname: Conda-Sheridan
authors.forename: Sungsoo S
authors.initials: SS
authors.lastname: Lee
authors.forename: Adam T
authors.initials: AT
authors.lastname: Preslar
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Stupp
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000737:chemistry; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D004950:Esterases / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000187:drug effects; D051379:Mice; D046529:Microscopy, Electron, Transmission; D057139:Nanofibers / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D009288:Naproxen / Q000008:administration & dosage / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D010455:Peptides; D009288:Naproxen; D051546:Cyclooxygenase 2; D004950:Esterases