title: Measuring and optimizing results in multipolar RFA: Techniques and early findings in an experimental setting.
abstract: Radiofrequency ablation (RFA) has shown to be a reasonable alternative for the treatment of hepatic tumors and metastases although multiple limitations remain. Cooling effects due to larger vessels can prevent complete coverage and may lead to early tumor relapse. This preliminary in vivo pig study combines the use of multipolar RFA with three applicators (six electrodes) and interrupted liver perfusion using Pringle's maneuver to overcome the most serious limitations. Furthermore, immediate detection of incomplete RFA is important to revise ablation. We used contrast enhanced computed tomography (CECT) to evaluate post ablation results in comparison to macroscopic images in healthy pig liver. We found significantly (p = 0.001) larger ablation zones and no affection by larger vessels with interrupted liver perfusion. This allows effective RFA for larger tumors. Immediate postinterventional CECT provided comparable results (r = 0.985) to macroscopic evaluation.
authors.affiliation: Department of Radiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Janis L
authors.initials: JL
authors.lastname: Vahldiek
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Kai S
authors.initials: KS
authors.lastname: Lehmann
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Franz
authors.initials: F
authors.lastname: Poch
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Urte
authors.initials: U
authors.lastname: Zurbuchen
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Martin E
authors.initials: ME
authors.lastname: Kreis
authors.affiliation: Department of General, Vascular and Thoracic Surgery, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Ole
authors.initials: O
authors.lastname: Gemeinhardt
authors.affiliation: Department of Radiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Hamm
authors.affiliation: Department of Radiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Niehues
mesh_terms: D000818:Animals; D017115:Catheter Ablation; D003287:Contrast Media / Q000737:chemistry; D004566:Electrodes; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010477:Perfusion; D011846:Radio Waves; D013552:Swine; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media
keywords: *contrast media; Interventional/methods; Liver perfusion; animals; catheter ablation; electrodes; imaging; multidetector computed tomography; radiography; three-dimensional/*methods