title: Effect of metformin on sleep disorders in adolescent girls with polycystic ovarian syndrome.
abstract: OBJECTIVE
  Patients with polycystic ovarian syndrome (PCOS) have a high prevalence of sleep disorders. Metformin is an antidiabetic drug that may have a role in treatment of the manifestations of PCOS. The aim of this study was to assess the presence of sleep disorders in adolescent girls with PCOS and to study the effects of using metformin on sleep disorders in these girls.
  
  
  METHODS
  This study was carried out on 90 adolescent girls aging from 12 to 18 years who were divided into 3 equal groups: control untreated group, untreated PCOS group, and PCOS + metformin group. Body weight, height, body mass index, hirsutism score, fasting and postprandial blood glucose, fasting serum insulin, Homeostatic Model Assessment (HOMA) index, sleep disturbances scale, and Epworth sleepiness scale were measured.
  
  
  RESULTS
  Metformin administration resulted in significant decrease in the body weight, body mass index, hirsutism score, fasting and postprandial blood glucose, fasting serum insulin, HOMA index, sleep disturbances scale, and Epworth sleepiness scale compared to the untreated PCOS group.
  
  
  CONCLUSIONS
  Metformin can reduce the incidence of sleep disorders and excessive daytime sleepiness in adolescent girls with PCOS.
authors.affiliation: Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: El-Sharkawy
authors.affiliation: Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt.
authors.forename: Ghada S
authors.initials: GS
authors.lastname: Abdelmotaleb
authors.affiliation: Pediatric Department, Faculty of Medicine, Benha University, Benha, Egypt. Electronic address: dra_kabel@yahoo.com.
authors.forename: Mohammed K
authors.initials: MK
authors.lastname: Aly
authors.affiliation: Faculty of Medicine, Tanta University, Tanta, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Kabel
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D002648:Child; D005260:Female; D006628:Hirsutism / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008687:Metformin / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D012720:Severity of Illness Index; D012893:Sleep Wake Disorders / Q000150:complications / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008687:Metformin
keywords: Adolescent; Metformin; PCOS; Sleep