title: Regulatory decisions pertaining to aprotinin may be putting patients at risk.
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Paul C
authors.initials: PC
authors.lastname: Hébert
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont. dafergusson@ohri.ca.
authors.forename: Dean A
authors.initials: DA
authors.lastname: Fergusson
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Brian
authors.initials: B
authors.lastname: Hutton
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: C David
authors.initials: CD
authors.lastname: Mazer
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Stephen
authors.initials: S
authors.lastname: Fremes
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Morris
authors.initials: M
authors.lastname: Blajchman
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Charles
authors.initials: C
authors.lastname: MacAdams
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: George
authors.initials: G
authors.lastname: Wells
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Jim
authors.initials: J
authors.lastname: Robblee
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Jean
authors.initials: J
authors.lastname: Bussières
authors.affiliation: Centre de Recherche (Hébert), Centre Hospitalier de L'Université de Montréal, Montréal, Que.; Département de Médecine (Hébert), Université de Montréal, Montréal, Que.; Clinical Epidemiology Program (Fergusson), Ottawa Hospital Research Institute, Ottawa, Ont.; Department of Medicine (Fergusson, Hutton, Mazer), University of Ottawa, Ottawa, Ont.; Department of Anesthesia (Fremes), Keenan Center/Li Ka Shing Institute, St. Michael's Hospital, University of Toronto, Toronto, Ont.; Sunnybrook Health Sciences Centre, Department of Surgery (Blajchman), Division of Cardiac and Vascular Surgery, University of Toronto, Toronto, Ont.; Department of Pathology and Molecular Medicine (MacAdams), McMaster University, Hamilton, Ont.; Libin Cardiovascular Institute (Wells), University of Calgary, Calgary, Alta.; University of Ottawa Heart Institute (Robblee), Ottawa, Ont.; Hôpital Laval (Bussières), Institut Universitaire de Cardiologie et Pneumologie de l'Université Laval, Laval, Que.; Hamilton Health Science Centre (Teoh), McMaster University, Hamilton, Ont.
authors.forename: Kevin
authors.initials: K
authors.lastname: Teoh
mesh_terms: D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D007611:Aprotinin / Q000627:therapeutic use*; D002170:Canada; D002986:Clinical Trials as Topic; D017277:Drug Approval / Q000331:legislation & jurisprudence; D006801:Humans; D012306:Risk
chemical_list: D000933:Antifibrinolytic Agents; D007611:Aprotinin