title: The interaction between nutrition and the brain and its consequences for body weight gain and metabolism; studies in rodents and men.
abstract: Aberrant feeding behavior can lead to obesity and obesity-related medical consequences, such as insulin resistance and diabetes. Although alterations in glucose metabolism (i.e. insulin resistance), in the presence of excessive fat tissue are often explained by the consequences of dysfunctional adipose tissue, evidence is emerging that also altered brain functions might be an important determinant of insulin resistance. In this review, we provide an overview of how feeding behavior and obesity interact with brain circuitry and how these interactions affect glucose metabolism. Because brain circuitries involved in food intake have been shown to partly control glucose metabolism as well, targeting these circuitries in obese subjects might not only affect food intake and body weight but also glucose metabolism.
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreeg 9, F2-154, 1105 AZ Amsterdam, The Netherlands. Electronic address: s.e.lafleur@amc.uva.nl.
authors.forename: Susanne E
authors.initials: SE
authors.lastname: la Fleur
authors.affiliation: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Meibergdreeg 9, F2-154, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Mireille J
authors.initials: MJ
authors.lastname: Serlie
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004435:Eating / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D009752:Nutritional Status; D012377:Rodentia; D015430:Weight Gain / Q000502:physiology*
keywords: brain; dopamine; food intake; glucose metabolism; meal composition; meal pattern; neuropeptide Y; nutrition; obesity; serotonin