title: [Expression of CaMK II delta in cerebral cortex following traumatic brain injury].
abstract: OBJECTIVE
  To observe the time-course expression of calcium-calmodulin dependent protein kinase II delta (CaMK II delta) in cerebral cortex after traumatic brain injury (TBI).
  
  
  METHODS
  The TBI rat model was established. The expression of CaMK II delta in cerebral cortex around injured area was tested by Western blotting and immunohistochemical staining.
  
  
  RESULTS
  Western blotting revealed expression of CaMK II delta in normal rat brain cortex. It gradually increased after TBI, peaked after 3 days, and then returned to normal level. The result of immunohistochemical staining was consistent with that of Western blotting.
  
  
  CONCLUSIONS
  The expression of CaMK II delta around injured area after TBI increased initially and then decreased. It could be used as a new indicator for wound age determination following TBI.
authors.forename: Hong
authors.initials: H
authors.lastname: Pan
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Xu
authors.forename: Zhen-Yong
authors.initials: ZY
authors.lastname: Gu
authors.forename: Lu-Yang
authors.initials: LY
authors.lastname: Tao
authors.forename: Ming-Yang
authors.initials: MY
authors.lastname: Zhang
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001930:Brain Injuries / Q000378:metabolism*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005554:Forensic Medicine; D007150:Immunohistochemistry; D051381:Rats; D013997:Time Factors
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2