title: Comprehensive two-dimensional gas chromatography-mass spectrometry: Recent evolution and current trends.
abstract: The present contribution is focused on the evolution and current trends of comprehensive two-dimensional gas chromatography-mass spectrometry (GC × GC-MS), with respect to a review that described this specific methodology published at the beginning of 2008 (Mondello et al., 2008). In fact, since then there has been considerable evolution in the MS field, certainly exceeding that observed in GC × GC. In particular, the present paper will cover the combination of novel MS machines [single quadrupole (Q) and triple quadrupole, isotope ratio, low- and high-resolution time-of-flight (ToF), hybrid (Q-ToF)] to GC × GC systems, and will position comprehensive two-dimensional gas chromatography within the wider context of separation science. © 2014 Wiley Periodicals, Inc. Mass Spec Rev 35:524-534, 2016.
authors.affiliation: Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.
authors.forename: Peter Q
authors.initials: PQ
authors.lastname: Tranchida
authors.affiliation: Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.
authors.forename: Flavio A
authors.initials: FA
authors.lastname: Franchina
authors.affiliation: Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.|Centro Integrato di Ricerca (C.I.R.), Università Campus Bio-Medico, Via Álvaro del Portillo, 21, 00128, Roma, Italy.|Chromaleont s.r.l. A Start-up of the University of Messina, c/o Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Dugo
authors.affiliation: Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.|Centro Integrato di Ricerca (C.I.R.), Università Campus Bio-Medico, Via Álvaro del Portillo, 21, 00128, Roma, Italy.|Chromaleont s.r.l. A Start-up of the University of Messina, c/o Dipartimento di Scienze del Farmaco e Prodotti per la Salute, Università di Messina, viale Annunziata, 98168, Messina, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Mondello
keywords: comprehensive two-dimensional gas chromatography; high resolution mass spectrometry; quadrupole mass spectrometry; tandem mass spectrometry; time-of-flight mass spectrometry