title: Multifunctional nanocarriers for simultaneous encapsulation of hydrophobic and hydrophilic drugs in cancer treatment.
abstract: Combination therapy for cancer patients is an important standard of care protocol because it can elicit synergistic therapeutic effects and reduce systemic toxicity by simultaneously modulating multiple cell-signaling pathways and overcoming multidrug resistance. Nanocarriers are expected to play a major role in delivering multiple drugs to tumor tissues by overcoming biological barriers. However, especially considering the different physical chemistry of chemotherapeutic drugs, it is highly desirable to develop a codelivery nanocarrier for controlled and targeted delivery of both hydrophobic and hydrophilic drugs. This review reports the recent developments in various combinational drug delivery systems and the simultaneous use of combinational drug delivery systems with functional agents.
authors.affiliation: Department of Materials Science & Engineering, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Su
authors.forename: Chih-Sheng
authors.initials: CS
authors.lastname: Chiang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Li
authors.forename: Shang-Hsiu
authors.initials: SH
authors.lastname: Hu
authors.forename: San-Yuan
authors.initials: SY
authors.lastname: Chen
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000737:chemistry*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy*; D010316:Particle Size
chemical_list: D053769:Nanocapsules
keywords: combination therapy; controlled drug release; imaging; nanocarrier; stimuli-sensitive; targeting