title: Investigation of inclusion complex of honokiol with sulfobutyl ether-β-cyclodextrin.
abstract: This study aimed to prepare and characterize an inclusion complex of honokiol (HNK) with sulfobutyl ether-β-cyclodextrin (SB-β-CD). The inclusion complex (HNK/CD COMP) was prepared utilizing a freeze-drying method. Phase-solubility curves were employed to obtain stability constants and thermodynamic parameters. The phase-solubility diagram showed a typical A(L)-type, indicating that the 1:1 (HNK:SB-β-CD) inclusion complex was formed. The solid inclusion complex was then characterized by differential scanning calorimetry and Fourier transform infrared spectroscopy. Results showed that HNK/CD COMP exhibited a higher drug release rate than free HNK in vitro. A comparative study of the pharmacokinetics between HNK/CD COMP and free HNK was also performed in rats. In vivo results indicated that AUC0-t and Cmax of HNK/CD COMP increased by approximately 158% and 123% compared with those of the free HNK, respectively. These results suggest that SB-β-CD will be potentially useful in the delivery of poorly soluble drugs, such as HNK.
authors.affiliation: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Caibing
authors.initials: C
authors.lastname: Xu
authors.affiliation: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Yalan
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Chongqingshi Shapingba District People's Hospital, Chongqing 400030, PR China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Hu
authors.affiliation: The Experimental Teaching Centre, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Rui
authors.initials: R
authors.lastname: Tian
authors.affiliation: Department of Pharmacy, Children's Hospital of Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Yuntao
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Deng
authors.affiliation: Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, PR China. Electronic address: zlkdyx@gmail.com.
authors.forename: Liangke
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001682:Biological Availability; D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D065546:Drug Liberation; D005612:Freeze Drying; D017705:Lignans / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D001713:Biphenyl Compounds; D017705:Lignans; D047392:beta-Cyclodextrins; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C093196:SBE4-beta-cyclodextrin
keywords: Honokiol; In vitro release; Inclusion complex; Pharmacokinetic study; Sulfobutyl ether-β-cyclodextrin