title: Oral delivery of insulin using a lipoamino acid nanocarrier system.
abstract: Lipoamino acid nanocarriers based on the interactions between L-arginine and oleic acid were formulated with the aid of Tween 80 and explored as a novel carrier for the oral administration of insulin. The interaction between oleic acid and L-arginine was confirmed by FTIR, DSC/TGA, viscosity and surface tension measurements. The pharmacological activity of orally administered insulin-loaded nanocarriers (10, 25 and 50 IU/kg) was evaluated in healthy rabbits. Insulin loaded in lipoamino acid nanocarriers was therapeutically active as demonstrated by the remarkable reduction in blood glucose levels after oral administration of the preparation. A blood glucose lowering of 80% was achieved 4 h after administration of the oral insulin preparation. In addition, insulin-loaded nanocarriers decreased glycemia in a dose dependent manner, with the maximum effect noticed with 50 IU/kg. Moreover, a significant effect observed 1 h after administration suggested that these nanocarriers could be considered as a fast-acting preparation. These results clearly show that these lipoamino acid nanocarriers hold promising potential for oral delivery of insulin.
authors.forename: M
authors.initials: M
authors.lastname: Al-Remawi
authors.forename: I
authors.initials: I
authors.lastname: Maghrabi
authors.forename: A
authors.initials: A
authors.lastname: Elsayed
authors.forename: M
authors.initials: M
authors.lastname: Hamaidi
authors.forename: N
authors.initials: N
authors.lastname: Jaber
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002152:Calorimetry, Differential Scanning; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004563:Electrochemistry; D007328:Insulin / Q000008:administration & dosage*; D007408:Intestinal Absorption / Q000502:physiology; D036103:Nanotechnology; D010316:Particle Size; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013500:Surface Tension; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D007328:Insulin