title: Pseudofolliculitis cutis: a vexing disorder of hair growth.
abstract: Pseudofolliculitis cutis (PFC) is a troublesome and potentially disfiguring cutaneous disorder characterized by a chronic inflammatory response to ingrown hair. Despite a simple precipitating stimulus, ingrown hair, PFC has a relatively complex aetiology that can involve grooming practices, hair type, genetic predisposition and medication history. Curly hair and a single-nucleotide substitution in the gene encoding keratin 75 may act synergistically to increase the risk for developing this condition. PFC is most common in men of sub-Saharan African lineage, but can occur in men and women of many different ethnicities, particularly in body areas where hair is coarse, abundant and subject to traumatic removal. Treatment options for PFC can be divided into three main categories: modifying hair removal practices, managing symptoms with medication, and long-term hair removal with laser therapy. Laser hair removal is safe and effective in most skin types and has become increasingly popular among dermatologists in the treatment of PFC. However, it is imperative that the laser system and parameters are specifically matched to the patient's skin type.
authors.affiliation: Departments of Dermatology and Preventive Medicine and Community Health, Rutgers University New Jersey Medical School, Newark, NJ, U.S.A.
authors.forename: T J
authors.initials: TJ
authors.lastname: Jasterzbski
authors.forename: R A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D005499:Folliculitis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006204:Hair Removal / Q000009:adverse effects; D006801:Humans; D053564:Keratins, Hair-Specific / Q000235:genetics; D053531:Keratins, Type II / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011379:Prognosis
chemical_list: C502884:KRT75 protein, human; D053564:Keratins, Hair-Specific; D053531:Keratins, Type II