title: Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.
abstract: A rapid and efficient solvent-free one-pot synthesis of coumarin derivatives by Pechmann condensation reactions of phenols with ethyl acetoacetate using FeF3 as a catalyst under microwave irradiation is described. This one-pot synthesis on a solid inorganic support provides the products in good yields. The newly synthesized compounds were systematically characterized by IR, 1H-NMR, 13C-NMR, MS and elemental CHN analyses. The proposed solvent-free microwave irradiation method using the environmentally friendly catalyst FeF3 offers the unique advantages of high yields, shorter reaction times, easy and quick isolation of the products, excellent chemoselectivity, and a one-pot, green synthesis. The products were screened for antimicrobial activity, and the results showed that the compounds reacted against all the tested bacteria.
authors.affiliation: Department of Chemistry, Faculty of Science, Islamic Azad University-Tonekabon Branch, Tonekabon 46841-61167, Iran. vahidvahabi20@gmail.com.
authors.forename: Vahid
authors.initials: V
authors.lastname: Vahabi
authors.affiliation: Department of Chemistry, Faculty of Science, Islamic Azad University-Tonekabon Branch, Tonekabon 46841-61167, Iran. f_hatamjafari@tonekaboniau.ac.ir.
authors.forename: Farhad
authors.initials: F
authors.lastname: Hatamjafari
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D012997:Solvents / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D000890:Anti-Infective Agents; D003374:Coumarins; D005290:Ferric Compounds; D012997:Solvents; C545851:ferric fluoride; C030123:coumarin; D005459:Fluorides