title: [Effect of urapidil combined with phentolamine on hypertension during extracorporeal circulation].
abstract: OBJECTIVE
  To study the effect of urapidil combined with phentolamine in the management of hypertension during extracorporeal circulation.
  
  
  METHODS
  Ninety patients undergoing aortic and mitral valve replacement were randomly divided into 3 equal groups to receive treatment with phentolamine (group A), urapidil (group B), or both (group C) during extracorporeal circulation. The mean arterial pressure (MAP) before and after drug administration, time interval of two administrations, spontaneous recovery of heart beat after aorta unclamping, ventricular arrhythmia, changes of ST-segment 1 min after the recovery of heart beat, ante-parallel cycle time, aorta clamping time, post-parallel cycle time, dopamine dose after cardiac resuscitation, and perioperative changes of plasma TNF-α and IL-6 levels were recorded.
  
  
  RESULTS
  There was no significant difference in MAP between the 3 groups before or after hypotensive drug administration (P>0.05). The time interval of two hypotensive drug administrations was longer in group C than in groups A and B (P<0.05). The incidence of spontaneous recovery of heart beat after aorta unclamping, incidence of ventricular arrhythmia, changes of ST-segment 1 min after the recovery of heart beat, ante-parallel cycle time, aorta clamping time, and post-parallel cycle time were all comparable between the 3 groups. The dose of dopamine administered after cardiac resuscitation was significantly larger in group B than in groups A or group C (P<0.05). The plasma levels of TNF-α and IL-6 were significantly increased after CPB and after the operation in all the groups, but were lowed in group C than in groups A and B at the end of CPB and at 2 h and 12 after the operation.
  
  
  CONCLUSIONS
  Urapidil combined with phentolamine can control hypertension during extracorporeal circulation without causing hypotension.
authors.affiliation: Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China. E-mail: wfjlxy006@126.com.
authors.forename: Fangjun
authors.initials: F
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Faping
authors.initials: F
authors.lastname: Tu
mesh_terms: D005112:Extracorporeal Circulation; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D015850:Interleukin-6 / Q000097:blood; D010646:Phentolamine / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D010879:Piperazines; D014409:Tumor Necrosis Factor-alpha; C015568:urapidil; D010646:Phentolamine