title: LRRK2 G2385R and R1628P mutations are associated with an increased risk of Parkinson's disease in the Malaysian population.
abstract: The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certain Asian populations but have not been studied in the Malaysian population. Therefore, we screened the G2385R and R1628P variants in 1,202 Malaysian subjects consisting of 695 cases and 507 controls. The G2385R and R1628P variants were associated with a 2.2-fold (P = 0.019) and 1.2-fold (P = 0.054) increased risk of PD, respectively. Our data concur with other reported findings in Chinese, Taiwanese, Singaporean, and Korean studies.
authors.affiliation: Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Aroma Agape
authors.identifier: 0000-0001-5949-7320
authors.initials: AA
authors.lastname: Gopalai
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Shen-Yang
authors.identifier: 0000-0002-6942-2522
authors.initials: SY
authors.lastname: Lim
authors.affiliation: Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Jing Yi
authors.initials: JY
authors.lastname: Chua
authors.affiliation: Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Shelisa
authors.identifier: 0000-0002-3569-7739
authors.initials: S
authors.lastname: Tey
authors.affiliation: Department of Neurology, Hospital Pulau Pinang, 10990 Penang, Malaysia.
authors.forename: Thien Thien
authors.initials: TT
authors.lastname: Lim
authors.affiliation: Division of Neurology, Department of Medicine, Hospital Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia.
authors.forename: Norlinah
authors.initials: N
authors.lastname: Mohamed Ibrahim
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Ai Huey
authors.initials: AH
authors.lastname: Tan
authors.affiliation: Department of Neurology, Hospital Pulau Pinang, 10990 Penang, Malaysia.
authors.forename: Gaik Bee
authors.initials: GB
authors.lastname: Eow
authors.affiliation: Division of Neurology, Department of Medicine, Hospital Sultanah Nur Zahirah, 20400 Kuala Terengganu, Malaysia.
authors.forename: Zariah
authors.initials: Z
authors.lastname: Abdul Aziz
authors.affiliation: Department of Neurology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia.
authors.forename: Santhi Datuk
authors.initials: SD
authors.lastname: Puvanarajah
authors.affiliation: Department of Neurology, Hospital Kuala Lumpur, 50586 Kuala Lumpur, Malaysia.
authors.forename: Shanthi
authors.initials: S
authors.lastname: Viswanathan
authors.affiliation: Department of Medicine, Hospital Seberang Jaya, 13700 Penang, Malaysia.
authors.forename: Irene
authors.identifier: 0000-0001-6217-5410
authors.initials: I
authors.lastname: Looi
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Soo Kun
authors.initials: SK
authors.lastname: Lim
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Li Ping
authors.initials: LP
authors.lastname: Tan
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yip Boon
authors.initials: YB
authors.lastname: Chong
authors.affiliation: Divisions of Neurology and Nephrology, Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Chong Tin
authors.initials: CT
authors.lastname: Tan
authors.affiliation: Department of Clinical Research and Neurology, Singapore General Hospital, Singapore 169608.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Clinical Research and Neurology, Singapore General Hospital, Singapore 169608.
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.affiliation: Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Azlina
authors.identifier: 0000-0001-6329-4366
authors.initials: A
authors.lastname: Ahmad-Annuar
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases