title: Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model.
abstract: Mitochondrial impairment as evidenced by decline in adenosine 5'-triphosphate (ATP) is associated with oxidative stress in Alzheimer's disease neuropathology and suggests that mitochondria may fail to maintain cellular energy, through reduced ATP production in neurons. To gain insights into the ATP characteristics of Alzheimer's disease transgenic (Tg) mice, we investigated ATP contents in the brain and whole blood of Tg mice at three ages (1-, 5-, and 24-months old). Overall, our results demonstrate that tissue ATP contents in Tg mice are significantly reduced, suggesting a decrease of tissue ATP production and mitochondrial dysfunction.
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Rissman
authors.affiliation: Department of Biomedical Engineering, Louisiana Tech University, Ruston, LA, USA Division of Technology, Engineering and Mathematics, Bossier Parish Community College, Bossier City, LA, USA.
authors.forename: June
authors.initials: J
authors.lastname: Feng
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000375:Aging / Q000378:metabolism; D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D008163:Luminescent Measurements; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000235:genetics / Q000378:metabolism
chemical_list: C545487:APP protein, human; D016564:Amyloid beta-Protein Precursor; C508853:PSEN1 protein, human; D053764:Presenilin-1; D000255:Adenosine Triphosphate
keywords: Adenosine 5′-triphosphate (ATP) contents; Alzheimer's disease; Alzheimer's disease transgenic mouse model; oxidative stress