title: Precision medicine in chronic disease management: The multiple sclerosis BioScreen.
abstract: We present a precision medicine application developed for multiple sclerosis (MS): the MS BioScreen. This new tool addresses the challenges of dynamic management of a complex chronic disease; the interaction of clinicians and patients with such a tool illustrates the extent to which translational digital medicine-that is, the application of information technology to medicine-has the potential to radically transform medical practice. We introduce 3 key evolutionary phases in displaying data to health care providers, patients, and researchers: visualization (accessing data), contextualization (understanding the data), and actionable interpretation (real-time use of the data to assist decision making). Together, these form the stepping stones that are expected to accelerate standardization of data across platforms, promote evidence-based medicine, support shared decision making, and ultimately lead to improved outcomes.
authors.affiliation: Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA.
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Gourraud
authors.forename: Roland G
authors.initials: RG
authors.lastname: Henry
authors.forename: Bruce A C
authors.initials: BA
authors.lastname: Cree
authors.forename: Jason C
authors.initials: JC
authors.lastname: Crane
authors.forename: Antoine
authors.initials: A
authors.lastname: Lizee
authors.forename: Marram P
authors.initials: MP
authors.lastname: Olson
authors.forename: Adam V
authors.initials: AV
authors.lastname: Santaniello
authors.forename: Esha
authors.initials: E
authors.lastname: Datta
authors.forename: Alyssa H
authors.initials: AH
authors.lastname: Zhu
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Bevan
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Gelfand
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Graves
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Goodin
authors.forename: Ari J
authors.initials: AJ
authors.lastname: Green
authors.forename: H-Christian
authors.initials: HC
authors.lastname: von Büdingen
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Waubant
authors.forename: Scott S
authors.initials: SS
authors.lastname: Zamvil
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Crabtree-Hartman
authors.forename: Sarah
authors.initials: S
authors.lastname: Nelson
authors.forename: Sergio E
authors.initials: SE
authors.lastname: Baranzini
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Hauser
mesh_terms: D016208:Databases, Factual; D019468:Disease Management; D019317:Evidence-Based Medicine; D006801:Humans; D007257:Information Theory; D009103:Multiple Sclerosis / Q000628:therapy*; D012984:Software