title: Complication of treatment of carcinoma in situ of the bladder with photodynamic targeted cystodiathermy.
abstract: We report two cases of bladder contracture following photodynamic or 'blue light' detection and cystodiathermy for bladder carcinoma in situ. These patients were unsuitable for treatment with immunotherapy/chemotherapy or had disease recurrence following such treatment. Radical cystectomy was not a treatment option in either patient. Each underwent serial photodynamic cystodiathermy over a three-year period. Neither patient developed muscle invasive disease. However, treatment resulted in contracture of the bladder and incontinence of urine. Patients need to be fully aware of this potential complication in order to make informed choices about their care.
authors.affiliation: University Hospitals of Leicester NHS Trust, UK.
authors.forename: K
authors.initials: K
authors.lastname: Murtagh
authors.forename: R
authors.initials: R
authors.lastname: Kockelbergh
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000473:pathology*; D002921:Cicatrix / Q000209:etiology / Q000503:physiopathology; D003131:Combined Modality Therapy; D003558:Cystoscopy / Q000379:methods; D004564:Electrocoagulation / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D010778:Photochemotherapy / Q000009:adverse effects* / Q000379:methods; D018570:Risk Assessment; D012494:Sampling Studies; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology; D014549:Urinary Incontinence / Q000209:etiology / Q000503:physiopathology
chemical_list: D001500:BCG Vaccine