title: Reversed-phase TLC study of some long chain arylpiperazine of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives.
abstract: The chromatographic parameters of arylpiperazinylpropyl derivatives of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione were investigated using reversed-phase thin layer chromatography method. The results revealed that R(M0) of investigated compounds depended on substituent in arylpiperazinyl fragment as well as on a nature of (cycloalkyl)aromatic ring at 5 position of imidazolidine-2,4-dione and at 7 position of imidazo[2,1-f]theophylline. The R(M0) parameters were compared with computationally calculated partition coefficients values by principal component analysis (PCA). To verify the influence of lipophilic parameter of investigated compounds on their biological activity the statistical analysis of Mann-Whitney was performed.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zagórska
authors.forename: Anna
authors.initials: A
authors.lastname: Czopek
authors.forename: Karolina
authors.initials: K
authors.lastname: Pełka
authors.forename: Krystyna
authors.initials: K
authors.lastname: Stanisz-Wallis
authors.forename: Maciej
authors.initials: M
authors.lastname: Pawłowski
mesh_terms: D056148:Chromatography, Reverse-Phase / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D003198:Computer Simulation; D006827:Hydantoins / Q000032:analysis*; D015394:Molecular Structure; D010879:Piperazines / Q000032:analysis*; D025341:Principal Component Analysis; D011687:Purines / Q000032:analysis*
chemical_list: D006827:Hydantoins; D010879:Piperazines; D011687:Purines