title: Association of vWA and TPOX polymorphisms with venous thrombosis in Mexican mestizos.
abstract: OBJECTIVE
  Venous thromboembolism (VTE) is a multifactorial disorder and, worldwide, the most important cause of morbidity and mortality. Genetic factors play a critical role in its aetiology. Microsatellites are the most important source of human genetic variation having more phenotypic effect than many single nucleotide polymorphisms. Hence, we evaluate a possible relationship between VTE and the genetic variants in von Willebrand factor, human alpha fibrinogen, and human thyroid peroxidase microsatellites to identify possible diagnostic markers.
  
  
  METHODS
  Genotypes were obtained from 177 patients with VTE and 531 nonrelated individuals using validated genotyping methods. The allelic frequencies were compared; Bayesian methods were used to correct population stratification to avoid spurious associations.
  
  
  RESULTS
  The vWA-18, TPOX-9, and TPOX-12 alleles were significantly associated with VTE. Moreover, subjects bearing the combination vWA-18/TPOX-12 loci exhibited doubled risk for VTE (95% CI = 1.02-3.64), whereas the combination vWA-18/TPOX-9 showed an OR = 10 (95% CI = 4.93-21.49).
  
  
  CONCLUSIONS
  The vWA and TPOX microsatellites are good candidate biomarkers in venous thromboembolism diseases and could help to elucidate their origins. Additionally, these polymorphisms could become useful markers for genetic studies of VTE in the Mexican population; however, further studies should be done owing that this data only show preliminary evidence.
authors.affiliation: Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Meraz-Ríos
authors.affiliation: Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, México, DF, Mexico.
authors.forename: Abraham
authors.initials: A
authors.lastname: Majluf-Cruz
authors.affiliation: Laboratorio Biología Molecular Diagnóstica (BIMODI), Querétaro, QRO, Mexico.
authors.forename: Carla
authors.initials: C
authors.lastname: Santana
authors.affiliation: Laboratorio Biología Molecular Diagnóstica (BIMODI), Querétaro, QRO, Mexico.
authors.forename: Gino
authors.initials: G
authors.lastname: Noris
authors.affiliation: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Camacho-Mejorado
authors.affiliation: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Leonor C
authors.initials: LC
authors.lastname: Acosta-Saavedra
authors.affiliation: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Emma S
authors.initials: ES
authors.lastname: Calderón-Aranda
authors.affiliation: Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, México, DF, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernández-Juárez
authors.affiliation: Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación, Secretaría de Salud, México, DF, Mexico.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Magaña
authors.affiliation: Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav-IPN), Avenida Instituto Politécnico Nacional 2508, Colonia San Pedro Zacatenco, 07360 México, DF, Mexico.
authors.forename: Rocío
authors.initials: R
authors.lastname: Gómez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D007453:Iodide Peroxidase / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D012307:Risk Factors; D020246:Venous Thrombosis / Q000208:ethnology* / Q000235:genetics*; D055815:Young Adult; D014841:von Willebrand Factor / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D014841:von Willebrand Factor; D007453:Iodide Peroxidase