title: Penicillinase-producing plasmid types in Neisseria gonorrhoeae clinical isolates from Australia.
abstract: Penicillinase-producing Neisseria gonorrhoeae (PPNG) carrying the blaTEM-135 gene is of particular concern, as it is considered a stepping stone toward resistance to extended-spectrum cephalosporins. Here, we sought to characterize plasmid types and the occurrence of the blaTEM-135 gene for N. gonorrhoeae clinical isolates from Australia. We found that blaTEM-135 was prevalent in Australian PPNG and was detected on all three major plasmid types.
authors.affiliation: Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Health Services, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia d.whiley@uq.edu.au.
authors.forename: David
authors.initials: D
authors.lastname: Whiley
authors.affiliation: Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Health Services, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Ella
authors.initials: E
authors.lastname: Trembizki
authors.affiliation: Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Health Services, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Cameron
authors.initials: C
authors.lastname: Buckley
authors.affiliation: Microbiology Laboratory, Pathology Department, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
authors.forename: Kevin
authors.initials: K
authors.lastname: Freeman
authors.affiliation: Microbiology and Infectious Diseases Department, Women's and Children's Hospital, North Adelaide, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Lawrence
authors.affiliation: WHO Collaborating Centre for STD, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales, Australia.
authors.forename: Athena
authors.initials: A
authors.lastname: Limnios
authors.affiliation: PathWest Laboratory Medicine-WA, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: Julie
authors.initials: J
authors.lastname: Pearson
authors.affiliation: Public Health Microbiology, Communicable Disease, Queensland Health Forensic and Scientific Services, Archerfield, Queensland, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Smith
authors.affiliation: Microbiological Diagnostic Unit, Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
authors.forename: Kerrie
authors.initials: K
authors.lastname: Stevens
authors.affiliation: WHO Collaborating Centre for STD, Microbiology Department, South Eastern Area Laboratory Services, Prince of Wales Hospital, Sydney, New South Wales, Australia.
authors.forename: Monica M
authors.initials: MM
authors.lastname: Lahra
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001315:Australia; D015373:Bacterial Typing Techniques; D018550:Cephalosporin Resistance / Q000235:genetics*; D002511:Cephalosporins / Q000494:pharmacology; D006069:Gonorrhea / Q000382:microbiology / Q000635:transmission; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D010403:Penicillin Resistance / Q000235:genetics*; D010405:Penicillinase / Q000235:genetics*; D010406:Penicillins / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry* / Q000145:classification
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D010405:Penicillinase