title: The Role of Extracellular Vesicles in Modulating the Host Immune Response during Parasitic Infections.
abstract: Parasites are the cause of major diseases affecting billions of people. As the inflictions caused by these parasites affect mainly developing countries, they are considered as neglected diseases. These parasitic infections are often chronic and lead to significant immunomodulation of the host immune response by the parasite, which could benefit both the parasite and the host and are the result of millions of years of co-evolution. The description of parasite extracellular vesicles (EVs) in protozoa and helminths suggests that they may play an important role in host-parasite communication. In this review, recent studies on parasitic (protozoa and helminths) EVs are presented and their potential use as novel therapeutical approaches is discussed.
authors.affiliation: Àrea de Parasitologia, Departament de Biologia Cel.lular i Parasitologia, Universitat de València , Burjassot , Spain.
authors.forename: Sergio
authors.initials: S
authors.lastname: Montaner
authors.affiliation: Àrea de Parasitologia, Departament de Biologia Cel.lular i Parasitologia, Universitat de València , Burjassot , Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Galiano
authors.affiliation: Àrea de Parasitologia, Departament de Biologia Cel.lular i Parasitologia, Universitat de València , Burjassot , Spain.
authors.forename: María
authors.initials: M
authors.lastname: Trelis
authors.affiliation: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona) , Barcelona , Spain.
authors.forename: Lorena
authors.initials: L
authors.lastname: Martin-Jaular
authors.affiliation: Barcelona Centre for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona) , Barcelona , Spain ; Institució Catalana de Recerca i Estudis Avançats , Barcelona , Spain.
authors.forename: Hernando A
authors.initials: HA
authors.lastname: Del Portillo
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Universitat de València , Burjassot , Spain.
authors.forename: Dolores
authors.initials: D
authors.lastname: Bernal
authors.affiliation: Àrea de Parasitologia, Departament de Biologia Cel.lular i Parasitologia, Universitat de València , Burjassot , Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Marcilla
keywords: extracellular vesicles; helminth; immunomodulation; parasite; protozoa