title: A preoperative serum signature of CEA+/CA125+/CA19-9 ≥ 1000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer.
abstract: Pancreatectomy is associated with significant morbidity and unpredictable outcome, with few diagnostic tools to determine, which patients gain the most benefit from this treatment, especially before the operation. This study aimed to define a preoperative signature panel of serum markers to indicate response to pancreatectomy for pancreatic cancer. Over 1000 patients with pancreatic cancer treated at two independent high-volume institutions were included in this study and were divided into three groups, including resected, locally advanced and metastatic. Eight serum tumor markers most commonly used in gastrointestinal cancers were analyzed for patient outcome. Preoperative CA19-9 independently indicated surgical response in pancreatic cancer. Patients with CA19-9 ≥1000 U/mL generally had a poor surgical benefit. However, a subset of these patients still achieved a survival advantage when CA19-9 levels decreased postoperatively. CEA and CA125 in the presence of CA19-9 ≥1000 U/mL could independently predict the non-decrease of CA19-9 postoperatively. The combination of the three markers was useful for predicting a worse surgical outcome with a median survival of 5.1 months vs. 23.0 months (p < 0.001) for the training cohort and 7.0 months vs. 18.2 months (p < 0.001) for the validation cohort and also suggested a higher prevalence of early distant metastasis after surgery. Resected patients with this proposed signature showed no survival advantage over patients in the locally advanced group who did not receive pancreatectomy. Therefore, a preoperative serum signature of CEA(+)/CA125(+)/CA19-9 ≥1000 U/mL is associated with poor surgical outcome and can be used to select appropriate patients with pancreatic cancer for pancreatectomy.
authors.affiliation: Pancreatic Cancer Institute, Fudan University Shanghai Cancer Center, China; Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Huaxiang
authors.initials: H
authors.lastname: Xu
authors.forename: Wenquan
authors.initials: W
authors.lastname: Wang
authors.forename: Chuntao
authors.initials: C
authors.lastname: Wu
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Jingxuan
authors.initials: J
authors.lastname: Yang
authors.forename: Putao
authors.initials: P
authors.lastname: Cen
authors.forename: Jin
authors.initials: J
authors.lastname: Xu
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Long
authors.forename: Sushovan
authors.initials: S
authors.lastname: Guha
authors.forename: Deliang
authors.initials: D
authors.lastname: Fu
authors.forename: Quanxing
authors.initials: Q
authors.lastname: Ni
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
authors.forename: Suresh
authors.initials: S
authors.lastname: Chari
authors.forename: Angela L
authors.initials: AL
authors.lastname: McCleary-Wheeler
authors.forename: Martin E
authors.initials: ME
authors.lastname: Fernandez-Zapico
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Xianjun
authors.initials: X
authors.lastname: Yu
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D018394:CA-125 Antigen / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy / Q000379:methods; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen
keywords: pancreatic cancer; predictive potency; serum signature; surgical outcome