title: [The DMS 48: norms and diagnostic proprieties for Alzheimer's disease in elderly population from the AMI cohort study].
abstract: The DMS 48 is a visual recognition memory test designed to detect memory changes in early Alzheimer's disease (AD). The aim of this study was to produce normative scores for this test and to assess its psychometric properties in the detection of AD by comparison with a widely used test of verbal episodic memory: the story recall task of the Wechsler memory scale. Methods. Data were collected in a sample of 1002 agricultural retirees, aged 65 years and over, included in the AMI study, a population-based cohort conducted in Southwestern France. The sample used to establish normative data included 750 non-demented elderly while the sample used to study the properties of the test to detect AD included 751 participants whose 34 with AD. To assess AD detection accuracy, DMS 48 was compared to the Wechsler story recall task. Results. Age, sex, and education were significantly associated with DMS 48 performances. Therefore, normative scores were calculated according to sex, age, and educational level, and described by percentiles. Regarding the test properties for AD detection, DMS 48 presented a good balance between sensitivity (Se) and specificity (Sp) both for immediate (Se=70.6%; Sp=79.6%) and delayed recall (Se=79.4%; Sp=72.9%). It also showed high negative predictive values, around 98.5% for both recalls. Detection values were roughly similar to that of Wechsler story recall task.
  
  
  CONCLUSIONS
  The DMS 48 seems to be as reliable as the Wechsler story recall task with similar detection properties. The DMS 48 is a test easy to administer in clinical situations and could be a helpful tool for AD screening.
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Laetitia
authors.initials: L
authors.lastname: Rullier
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Fanny
authors.initials: F
authors.lastname: Matharan
authors.affiliation: Centre de recherche cerveau et cognition (Cerco), UMR 5549 (CNRS-UPS), Faculté de Médecine de Rangueil, Toulouse, France.
authors.forename: Emmanuel J
authors.initials: EJ
authors.lastname: Barbeau
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Hind
authors.initials: H
authors.lastname: Mokri
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Pérès
authors.affiliation: Inserm U897 « Épidémiologie et biostatistique », Université de Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests
keywords: Alzheimer’disease; DMS 48; diagnostic properties; elderly; norms; visual recognition memory