title: Aberrant miR-215 expression is associated with clinical outcome in breast cancer patients.
abstract: Dysregulation of microRNA plays critical roles in various malignancies. However, whether the aberrant expression of miR-215 in breast cancer is associated with malignancy, metastasis, or prognosis remains unknown. In this study, we demonstrated that the relative level of miR-215 expression was lower in cancer tissues compared with adjacent non-malignant tissues (p < 0.001). Low-miR-215 expression was observed to be closely correlated with higher tumor grade (p = 0.008), human epidermal growth factor receptor 2 (HER2) positivity (p = 0.006), HER2 positive breast cancer subtype (p = 0.016), and lymph node metastasis (p = 0.039). Moreover, patients with low-miR-215 expression showed shorter 5-year disease-specific survival (DSS) than the high-miR-215 expression group (p = 0.007). Multivariate analysis results revealed that miR-215 downexpression was an unfavorable prognostic factor for DSS in addition to tumor size, ER, and lymph node metastasis. Our results support the potential of miR-215 as a prognostic predictor for breast cancer with its high expression in cancer tissues and its relationship with other clinicopathologic factors and survival.
authors.affiliation: Department of Head and Neck, and Breast Surgery, Xinxiang Central Hospital, Xinxiang, 453000, Henan, People's Republic of China, zhousw2014@163.com.
authors.forename: Shu-wei
authors.initials: SW
authors.lastname: Zhou
authors.forename: Bei-bei
authors.initials: BB
authors.lastname: Su
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yue-qing
authors.initials: YQ
authors.lastname: Feng
authors.forename: Yu
authors.initials: Y
authors.lastname: Guo
authors.forename: Yun-xiang
authors.initials: YX
authors.lastname: Wang
authors.forename: Pan
authors.initials: P
authors.lastname: Qi
authors.forename: Sheng
authors.initials: S
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000096:biosynthesis*; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; C553667:MIRN215 microRNA, human; D035683:MicroRNAs