title: [The role of human 6-sulfo LacNAc dendritic cells (slanDCs) in autoimmunity and tumor diseases].
abstract: Dendritic cells play a central role in the regulation of immunological reactivity. The existence of functionally specialized populations of skin dendritic cells is a consequence of qualitatively different attacks on our organism. slanDCs are human inflammatory dendritic cells that are characterized by the specific expression of the carbohydrate 6-sulfo LacNAc (slan). After phenotypic maturation slanDCs are capable of producing very high amounts of proinflammatory mediators like IL-12, TNF-α, IL-1β â and IL-23. Recent data describe a potential role of slanDCs in a number of different diseases like psoriasis, lupus erythematosus but also tumor diseases and therefore open up new areas of research on their respective pathogenesis. Furthermore, as a basis of a directed therapeutic manipulation,a slanDC-specific targeting system has been developed. Future challenges of slanDC research include the elaboration of a deeper understanding of the significance of slanDCs for the regulation of adaptive and innate immune responses as well as a translation of this knowledge into therapeutic options.
authors.affiliation: Hautklinik, Universitätsklinikum Heidelberg, Heidelberg.
authors.forename: Thomas
authors.initials: T
authors.lastname: Döbel
authors.forename: Knut
authors.initials: K
authors.lastname: Schäkel
mesh_terms: D056704:Adaptive Immunity / Q000235:genetics* / Q000276:immunology; D000606:Amino Sugars / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D003713:Dendritic Cells / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood; D008178:Lupus Erythematosus, Cutaneous / Q000276:immunology / Q000628:therapy; D010641:Phenotype; D011565:Psoriasis / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012871:Skin Diseases / Q000235:genetics* / Q000276:immunology* / Q000628:therapy; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology* / Q000628:therapy
chemical_list: C467438:6-sulfo-LacNac; D000606:Amino Sugars; D018836:Inflammation Mediators