title: Interplay of drug metabolizing enzymes with cellular transporters.
abstract: Many endogenous and xenobiotic substances and their metabolites are substrates for drug metabolizing enzymes and cellular transporters. These proteins may not only contribute to bioavailability of molecules but also to uptake into organs and, consequently, to overall elimination. The coordinated action of uptake transporters, metabolizing enzymes, and efflux pumps, therefore, is a precondition for detoxification and elimination of drugs. As the understanding of the underlying mechanisms is important to predict alterations in drug disposal, adverse drug reactions and, finally, drug-drug interactions, this review illustrates the interplay between selected uptake/efflux transporters and phase I/II metabolizing enzymes.
authors.affiliation: Division of Clinical Pharmacy and Diagnostics, Department of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 14, 1090, Vienna, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Böhmdorfer
authors.forename: Alexandra
authors.initials: A
authors.lastname: Maier-Salamon
authors.forename: Juliane
authors.initials: J
authors.lastname: Riha
authors.forename: Stefan
authors.initials: S
authors.lastname: Brenner
authors.forename: Martina
authors.initials: M
authors.lastname: Höferl
authors.forename: Walter
authors.initials: W
authors.lastname: Jäger
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D001692:Biological Transport / Q000235:genetics / Q000502:physiology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000201:enzymology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics / Q000502:physiology*; D004798:Enzymes / Q000097:blood* / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000970:Antineoplastic Agents; D004798:Enzymes