title: Therapeutic efficacy of Broadline against notoedric mange in cats.
abstract: The efficacy of a novel topical combination of fipronil 8.3% w/v, (S)-methoprene 10 % w/v, eprinomectin 0.4% w/v, and praziquantel 8.3% w/v (Broadline, Merial) was evaluated in 18 cats naturally infested by Notoedres cati in a controlled, blinded clinical efficacy study. Cats were blocked on pretreatment bodyweight and randomly allocated to two groups of nine cats each. One group served as control (untreated) and one group was treated once topically with Broadline according to the label instructions. Skin scrapings (three scrapings per animal per occasion) were collected prior to treatment and every other week for 8 weeks thereafter and examined for live N. cati mites. In addition, lesions were evaluated at each sampling to monitor the clinical recovery. Based on live mite counts, efficacy against N. cati of a single topical administration with Broadline was >99%, and all treated cats recovered from clinical signs of notoedric mange. No treatment-related adverse events were observed.
authors.affiliation: Merial GmbH, Kathrinenhof Research Center, 83101, Rohrdorf, Germany, martin.knaus@merial.com.
authors.forename: Martin
authors.initials: M
authors.lastname: Knaus
authors.forename: Balázs
authors.initials: B
authors.lastname: Capári
authors.forename: Martin
authors.initials: M
authors.lastname: Visser
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004338:Drug Combinations; D005260:Female; D007559:Ivermectin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008726:Methoprene / Q000008:administration & dosage / Q000627:therapeutic use; D008924:Mite Infestations / Q000188:drug therapy*; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use; D011720:Pyrazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D040021:Sarcoptidae; D012867:Skin / Q000469:parasitology
chemical_list: D000977:Antiparasitic Agents; D004338:Drug Combinations; D011720:Pyrazoles; D011223:Praziquantel; D007559:Ivermectin; C101434:eprinomectin; D008726:Methoprene; C082360:fipronil