title: Efficiency of various vitamin doses for polyhypovitaminosis correction in rats.
abstract: A 5-fold decrease of the content of vitamin mixture in the ration and exclusion of vitamin E from this mixture over 4 weeks led to a significant growth delay in rats initially weighing 58.1±0.5 g, but was inessential for the growth rates of animals weighing 107.1±1.1 g. The decrease in the levels of vitamins A and B2 in the liver and of 25-hydroxyvitamin D in the plasma of younger rats was more significant, this indicating their higher sensitivity to alimentary vitamin deficit. The increase in vitamin content in the ration to 100% over 5 days led to a significant body weight increment but did not restore vitamin levels in the liver, restoring, however, plasma levels of vitamins E and 25-hydroxyvitamin D. Addition of 50% vitamin content of the vitamin mixture for controls to vitamin-deficient rations of older rats for 2 weeks improved the levels of vitamins B1 and B2, but was virtually inessential for the liver content of vitamins A and E. High dose (158-200%) vitamins in animals of both age groups repaired the deficit of all vitamins, except vitamin A, despite the fact that its doses were the highest. These results validate long-term vitamin consumption for repair of their deficit.
authors.affiliation: Research Institute of Nutrition, the Russian Academy of Medical Sciences, Moscow, Russia, kodentsova@ion.ru.
authors.forename: V M
authors.initials: VM
authors.lastname: Kodentsova
authors.forename: O A
authors.initials: OA
authors.lastname: Vrzhesinskaya
authors.forename: N A
authors.initials: NA
authors.lastname: Beketova
authors.forename: O V
authors.initials: OV
authors.lastname: Kosheleva
authors.forename: A A
authors.initials: AA
authors.lastname: Sokol'nikov
mesh_terms: D000818:Animals; D001361:Avitaminosis / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins