title: CancerPPD: a database of anticancer peptides and proteins.
abstract: CancerPPD (http://crdd.osdd.net/raghava/cancerppd/) is a repository of experimentally verified anticancer peptides (ACPs) and anticancer proteins. Data were manually collected from published research articles, patents and from other databases. The current release of CancerPPD consists of 3491 ACP and 121 anticancer protein entries. Each entry provides comprehensive information related to a peptide like its source of origin, nature of the peptide, anticancer activity, N- and C-terminal modifications, conformation, etc. Additionally, CancerPPD provides the information of around 249 types of cancer cell lines and 16 different assays used for testing the ACPs. In addition to natural peptides, CancerPPD contains peptides having non-natural, chemically modified residues and D-amino acids. Besides this primary information, CancerPPD stores predicted tertiary structures as well as peptide sequences in SMILES format. Tertiary structures of peptides were predicted using the state-of-art method, PEPstr and secondary structural states were assigned using DSSP. In order to assist users, a number of web-based tools have been integrated, these include keyword search, data browsing, sequence and structural similarity search. We believe that CancerPPD will be very useful in designing peptide-based anticancer therapeutics.
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Atul
authors.initials: A
authors.lastname: Tyagi
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Tuknait
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Anand
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Sudheer
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Minakshi
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Deepika
authors.initials: D
authors.lastname: Mathur
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Anshika
authors.initials: A
authors.lastname: Joshi
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Singh
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.affiliation: Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh 160036, Punjab, India raghava@imtech.res.in.
authors.forename: Gajendra P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000494:pharmacology*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D011506:Proteins