title: Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines.
abstract: Dendritic cells (DCs) play the central role in the priming of naive T cells and the differentiation of unique effector T cells. In this study, using lung tissues and blood from both humans and humanized mice, we analyzed the response of human CD1c(+) and CD141(+) DC subsets to live-attenuated influenza virus. Specifically, we analyzed the type of CD4(+) T cell immunity elicited by live-attenuated influenza virus-exposed DCs. Both DC subsets induce proliferation of allogeneic naive CD4(+) T cells with the capacity to secrete IFN-γ. However, CD141(+) DCs are uniquely able to induce the differentiation of IL-4- and IL-13-producing CD4(+) T cells. CD141(+) DCs induce IL-4- and IL-13-secreting CD4(+) T cells through OX40 ligand. Thus, CD141(+) DCs demonstrate remarkable plasticity in guiding adaptive immune responses.
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Chun I
authors.initials: CI
authors.lastname: Yu
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029; Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029;
authors.forename: Christian
authors.initials: C
authors.lastname: Becker
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Patrick
authors.initials: P
authors.lastname: Metang
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204;
authors.forename: Florentina
authors.initials: F
authors.lastname: Marches
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204; Institute of Biomedical Studies, Baylor University, Waco, TX 76798;
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan;
authors.forename: Hori
authors.initials: H
authors.lastname: Toshiyuki
authors.affiliation: The Jackson Laboratory for Genomic Medicine, Farmington, CT 06030; and.
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.affiliation: Immunology Institute, Mount Sinai School of Medicine, New York, NY 10029; Department of Oncological Sciences, Mount Sinai School of Medicine, New York, NY 10029.
authors.forename: Miriam
authors.initials: M
authors.lastname: Merad
authors.affiliation: Baylor Institute for Immunology Research, Dallas, TX 75204; Karolina.Palucka@jax.org.
authors.forename: A Karolina
authors.initials: AK
authors.lastname: Palucka
mesh_terms: D000818:Animals; D018949:Antigens, CD1 / Q000378:metabolism; D000954:Antigens, Surface / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D019013:CD40 Antigens / Q000378:metabolism; D002454:Cell Differentiation; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000821:virology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D053278:OX40 Ligand / Q000378:metabolism; D009975:Orthomyxoviridae / Q000276:immunology; D010641:Phenotype; D015398:Signal Transduction; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D018180:Thrombomodulin
chemical_list: D018949:Antigens, CD1; D000954:Antigens, Surface; C437944:CD1C protein, human; D019013:CD40 Antigens; D016207:Cytokines; D006023:Glycoproteins; D053278:OX40 Ligand; C546931:THBD protein, human; D018180:Thrombomodulin