title: Vasodilation Responses to Non-Selective α-Adrenergic Blockage of Coronary Bypass Grafts in Diabetic and Non-Diabetic Patients: In Vitro Study.
abstract: BACKGROUND
  Adrenergic tonus is increased in atherosclerotic coronary arteries. In this study, we aimed to demonstrate in vitro effects of phentolamine, a reversible nonselective alpha (α) adrenergic blocker, on coronary artery bypass grafts (CABG) and compare its effects in diabetic and nondiabetic patients.
  
  
  METHODS
  A total number of 30 patients (15 diabetic and 15 nondiabetic) who were assigned to elective CABG surgery were enrolled into the study. For both groups of patients, 16 internal mammarian artery (IMA) samples, 16 saphenous vein (SV) samples and 16 radial artery (RA) samples were collected and studied in the tissue bath system. The vasodilatation responses to increasing doses of phentolamine were recorded.
  
  
  RESULTS
  When grafts were compared in terms of amount of vasodilatation to phentolamine, IMA had the most prominent vasodilatation followed by RA and SV respectively. Although the vasodilatation responses in nondiabetic patients were numerically higher than diabetic patients, there was no statistically difference between the groups.
  
  
  CONCLUSIONS
  Phentolamine, a nonselective α adrenergic blocker, is proven to have equal vasodilatory effects in diabetic and nondiabetic CABG grafts and can safely be used both intravenously and topically in the perioperative period.
authors.affiliation: Department of Cardiovascular Surgery, Namık Kemal University Hospital, Tekirdag, Turkey.
authors.forename: Selami
authors.initials: S
authors.lastname: Gurkan
authors.forename: Ozcan
authors.initials: O
authors.lastname: Gur
authors.forename: Demet Ozkaramanli
authors.initials: DO
authors.lastname: Gur
authors.forename: Semil Selcen
authors.initials: SS
authors.lastname: Gocmez
authors.forename: Turan
authors.initials: T
authors.lastname: Ege
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000368:Aged; D001026:Coronary Artery Bypass / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D008323:Mammary Arteries / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D010646:Phentolamine / Q000494:pharmacology*; D011446:Prospective Studies; D017534:Radial Artery / Q000187:drug effects* / Q000503:physiopathology; D012501:Saphenous Vein / Q000187:drug effects* / Q000503:physiopathology; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D014665:Vasodilator Agents; D010646:Phentolamine