title: The efficacy of recombinant versus urinary HCG in ART outcome.
abstract: BACKGROUND
  Human chorionic gonadotropin (HCG) has been used as a replacement for the mid-cycle luteinizing hormone (LH) surge for several years. The recent arrival of recombinant DNA technology has made recombinant HCG (rHCG) accessible.
  
  
  OBJECTIVE
  To assess efficacy of rHCG compared to urinary HCG (uHCG) for triggering of ovulation and induction of final oocyte maturation in assisted reproductive cycles.
  
  
  METHODS
  200 patients who were candidate for ICSI were randomly divided in two groups. In group I (rHCG), patients received 250µg of rHCG for final oocyte maturation, and in group II (uHCG) the patients received 10000 IU of uHCG. Measured outcomes were number of retrieved oocyte and mature oocyte, maturation rate of oocyte, fertilization rate and clinical pregnancy rate.
  
  
  RESULTS
  The rates of oocyte maturity were similar in both groups. Fertilization rate was similar in two groups (58.58% in rHCG group versus 60.58% in uHCG group p=0.666). The clinical pregnancy rate per cycle was similar in both group 34.0% in rHCG group versus 39% in uHCG group (p=0.310).
  
  
  CONCLUSIONS
  We demonstrated that rHCG is as effective as uHCG, when it is used for final oocyte maturation in ICSI cycles. The numbers of retrieved oocyte and maturation rates were similar in both groups; also fertilization and clinical pregnancy rates were similar.
authors.affiliation: Department of Obstetrics and Gynecology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Eftekhar
authors.affiliation: Department of Embryology, Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Khalili
authors.affiliation: Department of Obstetrics and Gynecology, Bushehr University of Medical Sciences, Bushehr, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Rahmani
keywords: Assisted reproduction technology; Final follicular maturation; Ovulation; Recombinant HCG; Urinary HCG