title: Impaired fasting glucose and impaired glucose tolerance do not predict hypertension: a community cohort study.
abstract: BACKGROUND
  Insulin resistance has an important role in the pathogenesis of hypertension. We hypothesized that impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) which represents insulin resistance would predict the development of hypertension.
  
  
  METHODS
  A total of 4,039 subjects without hypertension or diabetes (1,847 men and 2,192 women; age 49.9±8.2 years), from the Ansan-Ansung cohorts within the Korean Genome Epidemiology Study, were enrolled in 2001-2002 and restudied in 2005-2006. The association between the incidence of hypertension and IFG, IGT, or other metabolic factors was studied.
  
  
  RESULTS
  During the 4-year follow-up period, 582 of the 4,039 subjects developed hypertension. At baseline, the prevalence of abdominal obesity, dyslipidemia, and IGT was higher in subjects who became hypertensive compared to those that remained normotensive. The prevalence of IFG was not significantly different between the 2 groups. In a multivariate analysis, abdominal obesity and high serum triglyceride were significant risk factors for the development of hypertension. Neither IFG nor IGT were significantly associated with new-onset hypertension. Although the risk of hypertension was higher with the number of metabolic components present at baseline, IFG and IGT were not significant components compared to other metabolic components, especially when abdominal obesity was taken into account.
  
  
  CONCLUSIONS
  While metabolic syndrome components related to insulin resistance present at baseline are important risk factors of hypertension, we conclude that coexisting metabolic component, mainly abdominal obesity, rather than IFG and IGT have more predictive value for determining the development of hypertension in a Korean population.
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute of Genetic Science, Integrated Genomic Research Center for Metabolic Regulation, BK21 PLUS project for Medical Science, Yonsei University College of Medicine, Seoul, Korea;
authors.forename: Chan Joo
authors.initials: CJ
authors.lastname: Lee
authors.affiliation: Division of Cardiovascular and Rare diseases, Center for Biomedical Science, National Institute of Health, Cheongwon-gun, Chungbuk, Korea;
authors.forename: Nam-Kyoo
authors.initials: NK
authors.lastname: Lim
authors.affiliation: Department of Preventive medicine, Yonsei University College of Medicine, Seoul, Korea;
authors.forename: Hyeon-Chang
authors.initials: HC
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea;
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Ihm
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea;
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Lee
authors.affiliation: Division of Cardiovascular and Rare diseases, Center for Biomedical Science, National Institute of Health, Cheongwon-gun, Chungbuk, Korea;
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Park
authors.affiliation: Division of Cardiology, Yonsei Cardiovascular Hospital, Yonsei Cardiovascular Research Institute, Yonsei University of Medicine, Seoul, Korea. shpark0530@yuhs.ac.
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D016009:Chi-Square Distribution; D050171:Dyslipidemias / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D056128:Obesity, Abdominal / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: abdominal obesity; blood pressure; hypertension; impaired fasting glucose; impaired glucose tolerance; insulin resistance.