title: Efficacy and safety of bone marrow cell transplantation for chronic ischemic heart disease: a meta-analysis.
abstract: BACKGROUND
  Although bone marrow-derived cells (BMCs) have shown great therapeutic potential in patients with chronic ischemic heart disease (CIHD), the exact efficacy and safety of BMCs therapy is still not completely defined.
  
  
  METHODS
  We searched PubMed, OVID, EMBASE, the Cochrane Library, and ClinicalTrials.gov and finally identified 20 qualified trials in this meta-analysis. Assessment of efficacy was based on left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), and left ventricular end-diastolic volume (LVEDV) improvement, by weighted mean difference (WMD) with 95% confidence intervals (CIs). RESULTS of all-cause death, ventricular arrhythmia, recurrent myocardial infarction, and cerebrovascular accident were pooled to assess safety. Subgroup analysis was performed by stratifying RCTs into 2 subgroups of those with revascularization and without revascularization.
  
  
  RESULTS
  BMC transplantation significantly improved LVEF in patients with revascularization (3.35%, 95% CI 0.72% to 5.97%, p=0.01; I2=85%) and without revascularization (3.05%, 95% CI 0.65% to 5.45%, p=0.01; I2=86%). In patients without revascularization, BMC transplantation was associated with significantly decreased LVESV (-11.75 ml, 95% CI -17.81 ml to -5.69 ml, p=0.0001; I2=81%), and LVEDV (-7.80 ml, 95% CI -15.31 ml to -0.29 ml, p=0.04; I2=39%). Subgroup analysis showed that the route of transplantation, baseline LVEF, and type of cells delivered could influence the efficacy of BMC transplantation.
  
  
  CONCLUSIONS
  Autologous transplantation of BMCs was safe and effective for patients who were candidates for revascularization with CABG/PCI and those who were not. However, large clinical trials and long-term follow-up are required to confirm these benefits.
authors.affiliation: Department of Medicine, Sichuan Scientific & Cellular Biotechnology Research Institute, Chengdu, China (mainland).
authors.forename: Chun
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Department of Medicine, Sichuan Scientific & Cellular Biotechnology Research Institute, Chengdu, China (mainland).
authors.forename: Shijie
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Medicine, Sichuan Scientific & Cellular Biotechnology Research Institute, Chengdu, China (mainland).
authors.forename: Yueqiang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Medicine, Sichuan Scientific & Cellular Biotechnology Research Institute, Chengdu, China (mainland).
authors.forename: Huozhen
authors.initials: H
authors.lastname: Hu
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002908:Chronic Disease; D003971:Diastole; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000628:therapy*; D017594:Publication Bias; D013318:Stroke Volume; D013599:Systole; D016896:Treatment Outcome; D016277:Ventricular Function, Left