title: Successful pregnancy in a Peutz-Jeghers syndrome patient with lobular endocervical glandular hyperplasia.
abstract: Lobular endocervical glandular hyperplasia (LEGH) is histologically similar to minimal deviation adenocarcinoma (MDA), but classified as a benign disease. Although MDA often develops in Peutz-Jeghers syndrome (PJS) patients, there have been only a few reports on PJS with LEGH. We report a PJS patient who was diagnosed with LEGH by conization and delivered a baby 42 months later. She was referred to our department for multicystic lesions in the uterine cervix at 26 years old. Diagnostic conization was performed, and the histopathological diagnosis was LEGH. As the possibility of MDA could not be ruled out because of concomitant PJS, hysterectomy was considered. However, course observation was selected because the patient strongly wished to preserve fertility. She delivered a baby at 30 years old. The finding that PJS patients may be complicated by LEGH is very important. Loss of fertility by over-treatment should be avoided if patients desire its preservation.
authors.affiliation: Department of Obstetrics and Gynecology, Jichi Medical University, Tochigi, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takei
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Tomomi
authors.initials: T
authors.lastname: Nagashima
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Suzuyo
authors.initials: S
authors.lastname: Takahashi
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000473:pathology*; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D059247:Fertility Preservation; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D010580:Peutz-Jeghers Syndrome / Q000150:complications*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000000981:diagnostic imaging / Q000473:pathology*; D011256:Pregnancy Outcome; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*
keywords: Peutz-Jeghers syndrome; fertility preservation; lobular endocervical glandular hyperplasia; pregnancy