title: Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines.
abstract: A facile and efficient synthetic protocol for the synthesis of α-amino amidines has been developed using a molecular iodine-catalyzed three-component coupling reaction of isocyanides, amines, and aldehydes. The presented strategy offers the advantages of mild reaction conditions, low environmental impact, clean and simple methodology, high atom economy, wide substrate scope and high yields.
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: Praveen Reddy
authors.initials: PR
authors.lastname: Adiyala
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: D
authors.initials: D
authors.lastname: Chandrasekhar
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: Jeevak Sopanrao
authors.initials: JS
authors.lastname: Kapure
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: Chada Narsimha
authors.initials: CN
authors.lastname: Reddy
authors.affiliation: Division of Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad-500007, India.
authors.forename: Ram Awatar
authors.initials: RA
authors.lastname: Maurya
keywords: Ugi reaction; iodine; isocyanide; multicomponent reaction; α-amino amidines