title: Circulating survivin levels in healthy and asthmatic pregnancy.
abstract: BACKGROUND
  Asthma is one of the most common conditions which complicate pregnancy. Pro- and anti-apoptotic mechanisms can be modulated by asthma accompanying pregnancy. Survivin, an anti-apoptotic protein has been implicated in the pathomechanism of asthma and also in the development of pathological pregnancies; however survivin has not been studied in pregnant asthmatics.
  
  
  METHODS
  Twenty-eight asthmatic pregnant (AP), 25 asthmatic non-pregnant (ANP), 21 healthy pregnant (HP) and 29 healthy non-pregnant (HNP) women were enrolled in this cross-sectional study. Plasma survivin concentration was determined by ELISA.
  
  
  RESULTS
  Plasma survivin was significantly lower in HP (1.64 /0-74.9/ pg/ml) than in HNP (24.6 /0-333.3/ pg/ml, p = 0.01). However, this difference was not observed between the asthmatic groups (p = 0.64). Similarly, there was no difference either between HNP and ANP (10.5 /0-215.4/ pg/ml, p = 0.23) or between HP and AP (13.9 /0-364.1/ pg/ml, p = 0.30) groups.
  
  
  CONCLUSIONS
  Decreased plasma survivin levels in physiological but not in asthmatic pregnancy may suggest that the normal apoptotic mechanisms are compromised in asthmatic gestation.
authors.affiliation: Department of Pulmonology, Semmelweis University, 1/C Dios arok, Budapest H-1125, Hungary. andras.bikov@gmail.com.
authors.forename: Andras
authors.initials: A
authors.lastname: Bikov
authors.forename: Renata
authors.initials: R
authors.lastname: Bocskei
authors.forename: Noemi
authors.initials: N
authors.lastname: Eszes
authors.forename: Aniko
authors.initials: A
authors.lastname: Bohacs
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Losonczy
authors.forename: Janos
authors.initials: J
authors.lastname: Rigo
authors.forename: Ildiko
authors.initials: I
authors.lastname: Horvath
authors.forename: Lilla
authors.initials: L
authors.lastname: Tamasi
mesh_terms: D000328:Adult; D017209:Apoptosis; D001249:Asthma / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D003430:Cross-Sectional Studies; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D006814:Hungary; D051034:Inhibitor of Apoptosis Proteins / Q000097:blood* / Q000378:metabolism; D010044:Outpatient Clinics, Hospital; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin