title: Effects of laparoscopic versus minilaparotomic myomectomy on uterine leiomyoma: a meta-analysis.
abstract: A meta-analysis was conducted to assess the effects of laparoscopic versus minilaparotomic myomectomy on uterine leiomyoma in premenopausal women. We performed a computerized search of MEDLINE, Embase, and the Cochrane Library from 1996 to 2104. From 711 studies, a total of 4 studies met our inclusion criteria, and a meta-analytic technique was used to study the 4 randomized controlled trials involving 577 women with symptomatic uterine leiomyoma. Compared with the minilaparotomic myomectomy group, the laparoscopic myomectomy group showed a significantly less hemoglobin drop and blood loss, lower postoperative analgesic use, shorter duration of postoperative ileus, shorter hospitalization days and recovery time, and higher levels in the pregnancy rate per cycle and the live birth rate per cycle. There was no significant difference between the 2 groups regarding the operating time, complications, laparotomic conversion rate, cumulative pregnancy rate, cumulative live birth rate, and abortion rates. When performed by experienced surgeons in selected patients (e.g., symptomatic leiomyoma women who have the indications for surgery), laparoscopic myomectomy is a better choice than minilaparotomic myomectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Tao
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics and Gynecology, Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. Electronic address: zjwzzxq@163.com.
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000328:Adult; D057186:Comparative Effectiveness Research; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000379:methods; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods; D007889:Leiomyoma / Q000473:pathology / Q000601:surgery; D018579:Patient Selection; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D063186:Uterine Myomectomy / Q000009:adverse effects / Q000379:methods; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery
keywords: Laparoscopic myomectomy; Leiomyoma; Meta-analysis; Minilaparotomic myomectomy