title: Effects of a new flavonoid and Myo-inositol supplement on some biomarkers of cardiovascular risk in postmenopausal women: a randomized trial.
abstract: Background and Aim. Cardiovascular risk is increased in women with menopause and metabolic syndrome. Aim of this study was to test the effect of a new supplement formula, combining cocoa polyphenols, myo-inositol, and soy isoflavones, on some biomarkers of cardiovascular risk in postmenopausal women with metabolic syndrome. Methods and Results. A total of 60 women were enrolled and randomly assigned (n = 30 per group) to receive the supplement (NRT: 30 mg of cocoa polyphenols, 80 mg of soy isoflavones, and 2 gr of myo-inositol), or placebo for 6 months. The study protocol included three visits (baseline, 6, and 12 months) for the evaluation of glucose, triglycerides, and HDL-cholesterol (HDL-C), adiponectin, visfatin, resistin, and bone-specific alkaline phosphatase (bone-ALP). At 6 months, a significant difference between NRT and placebo was found for glucose (96 ± 7 versus 108 ± 10 mg/dL), triglycerides (145 ± 14 versus 165 ± 18 mg/dL), visfatin (2.8 ± 0.8 versus 3.7 ± 1.1 ng/mL), resistin (27 ± 7 versus 32 ± 8 µg/L), and b-ALP (19 ± 7 versus 15 ± 5 µg/mL). No difference in HDL-C concentrations nor in adiponectin levels between groups was reported at 6 months. Conclusions. The supplement used in this study improves most of the biomarkers linked to metabolic syndrome. This Trial is registered with NCT01400724.
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Rosario
authors.initials: R
authors.lastname: D'Anna
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Angelo
authors.identifier: 0000-0002-0872-8042
authors.initials: A
authors.lastname: Santamaria
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Cannata
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Maria Lieta
authors.initials: ML
authors.lastname: Interdonato
authors.affiliation: Messina University Hospital, A.O.U. "G. Martino", 98125 Messina, Italy.
authors.forename: Grazia Maria
authors.initials: GM
authors.lastname: Giorgianni
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Granese
authors.affiliation: Department of Pediatric, Gynecological, Microbiological, and Biomedical Sciences, University of Messina, 98125 Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Corrado
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy.
authors.forename: Alessandra
authors.identifier: 0000-0001-9300-7532
authors.initials: A
authors.lastname: Bitto