title: Effect of childhood obesity prevention programmes on blood lipids: a systematic review and meta-analysis.
abstract: We aimed to assess the effects of childhood obesity prevention programmes on blood lipids in high-income countries. We searched MEDLINE®, Embase, PsychInfo, CINAHL®, clinicaltrials.gov, and the Cochrane Library up to 22 April 2013 for relevant randomized controlled trials, quasi-experimental studies and natural experiments published in English. Studies were included if they implemented diet and/or physical activity intervention(s) with ≥1 year follow-up (or ≥6 months for school-based intervention studies) in 2-18-year-olds, and were excluded if they targeted only overweight/obese children, or those with a pre-existing medical condition. Seventeen studies were finally included. For total cholesterol, the pooled intervention effect was -0.97 mg dL(-1) [95% confidence interval (CI): -3.26, 1.32; P = 0.408]; for low-density lipoprotein cholesterol (LDL-C), -6.06 mg dL(-1) (95% CI: -11.09, -1.02; P = 0.018); for high-density lipoprotein cholesterol (HDL-C), 1.87 mg dL(-1) (95% CI: 0.39, 3.34; P = 0.013); and for triglycerides, -1.95 mg dL(-1) (95% CI: -4.94, 1.04; P = 0.202). Most interventions (70%) showed similar significant or no effects on adiposity- and lipids outcomes: 15% interventions improved both adiposity- and lipids outcomes; 55% had no significant effects on either. Childhood obesity prevention programmes had a significant desirable effect on LDL-C and HDL-C. Two-thirds of interventions showed similar significant or no effects in adiposity- and lipids outcomes. Assessing lipids outcomes provide additional useful information on obesity prevention programme benefits.
authors.affiliation: Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China; Johns Hopkins Global Center on Childhood Obesity, Department of International Health, Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: L
authors.initials: L
authors.lastname: Cai
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: L J
authors.initials: LJ
authors.lastname: Cheskin
authors.forename: R F
authors.initials: RF
authors.lastname: Wilson
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D050154:Adiposity; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004032:Diet; D015444:Exercise; D006801:Humans; D008055:Lipids / Q000097:blood*; D016239:MEDLINE; D063766:Pediatric Obesity / Q000517:prevention & control*; D016032:Randomized Controlled Trials as Topic; D012572:School Health Services; D012959:Socioeconomic Factors; D016896:Treatment Outcome
chemical_list: D008055:Lipids
keywords: Child; lipids; obesity; prevention