title: Hyperbaric oxygen preconditioning protects lung against hyperoxic acute lung injury in rats via heme oxygenase-1 induction.
abstract: Hyperoxic acute lung injury (HALI) is a clinical syndrome as a result of prolonged supplement of high concentrations of oxygen. Previous studies have shown hyperbaric oxygen preconditioning (HBO-PC) had a protective effect on oxidative injury. In the present study, we investigated the effect of HBO-PC on HALI in rats. The results demonstrated that HBO-PC ameliorated the lung biochemical and histological alterations induced by hyperoxia, decreased oxidative products but increased antioxidant enzymes. Furthermore, HBO-PC up-regulated heme oxygenase-1 (HO-1) mRNA and activity in lung tissues. The administration of HO-1 inhibitor, Zinc protoporphyrin IX, abolished its protective effects. The data showed that HBO-PC could protect rats against HALI and the anti-oxidative effect may be related to the up-regulation of HO-1.
authors.affiliation: Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China.
authors.forename: Zinan
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Diseases, ChangHai Hospital, Second Military Medical University, Changhai Road 168#, Yangpu District, Shanghai 200433, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China.
authors.forename: Weihao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Respiratory Diseases, Jing'an District Centre Hospital of Shanghai (Huashan Hospital Fudan University Jing'an Branch), Xikang Road 259#, Jing'an District, Shanghai 200040, China. Electronic address: hfcao999@vip.sina.com.
authors.forename: Huifang
authors.initials: H
authors.lastname: Cao
mesh_terms: D055371:Acute Lung Injury / Q000473:pathology / Q000517:prevention & control*; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D006931:Hyperbaric Oxygenation / Q000379:methods*; D018496:Hyperoxia / Q000473:pathology / Q000517:prevention & control*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D011524:Protoporphyrins / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D055397:Ventilator-Induced Lung Injury / Q000473:pathology / Q000517:prevention & control*
chemical_list: D004791:Enzyme Inhibitors; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D007770:L-Lactate Dehydrogenase; D006419:Heme Oxygenase (Decyclizing); C491523:Hmox1 protein, rat
keywords: Heme oxygenase-1; Hyperbaric oxygen preconditioning; Hyperoxic acute lung injury; Oxidative stress