title: New withanolide, acyl and menthyl glucosides from fruits of Withania coagulans Dunal.
abstract: The fruits of Withania coagulans Dunal (family: Solanaceae) are sweet, sedative, emetic, alterative and diuretic; used to treat asthma, biliousness, strangury, wounds, dyspepsia, flatulent colic, liver complaints and intestinal infections. Phytochemical investigation of the fruits yielded a withanolide tetraglucoside identified as (20S, 22R)-5alpha, 20alpha-diacetoxy-6beta-hydroxy- 1-oxowitha-2,24-dienolide-6-beta-D-glucopyranosyl-(6' --> 1")-beta-D-glucopyranosyl-(6" --> 1''')-beta-D-glucopyranosyl-(6''' --> 1''''-beta-D-glucopyranoside), a capryloyl hexaglucoside formulated as n-octanoyl-beta-D-glucopyranosyl-(6a --> 1b)-beta-D-glucopyranosyl-(6b --> c)-beta-D-glucopyranosyl-(6c --> 1d)-beta-D-glucopyranosyl-(6d --> 1e)-glucopyranosyl-(6e --> 1f)-glucopyranoside and a menthyl tetraglucoside characterized as menthol-O-alpha-L-glucopyranosyl-(2a --> 1b)-O-alpha-L-glucopyranosyl-(2b --> 1c)-O-alpha-L-glucopyranosyl-(2c --> 1d)-O-alpha-L-glucopyranoside along with three fatty acid esters, n-nonacosanyl linolenate, n-octacosanyl linolenate and n-heptacosanyl linolenate. The structures of the isolated phytoconstituents have been established on the basis of spectral data analysis and chemical means.
authors.forename: Abuzer
authors.initials: A
authors.lastname: Ali
authors.forename: Mohd
authors.initials: M
authors.lastname: Jameel
authors.forename: Mohammed
authors.initials: M
authors.lastname: Ali
mesh_terms: D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification*; D005638:Fruit; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008610:Menthol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D032341:Withania / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D005227:Fatty Acids; D005960:Glucosides; D054358:Withanolides; D008610:Menthol