title: Gold-nanocrystal-enhanced bioluminescent nanocapsules.
abstract: Metal-enhanced bioluminescence presents a great opportunity to achieve ultrasensitive analysis and imaging with low bioluminescent background and enhanced luminescence. We hereby report metal-enhanced bioluminescence based on bioluminescent protein nanocapsules conjugated with gold nanocrystals. Such gold-nanocapsule complexes exhibit near 10-fold enhancement in bioluminescent intensity and are effectively delivered into the cells with outstanding stability. This work offers a class of bioluminescent nanoparticles for imaging and other applications.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of California at Los Angeles , Los Angeles, California 90095, United States.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Du
authors.forename: Jing
authors.initials: J
authors.lastname: Jin
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Talar
authors.initials: T
authors.lastname: Tokatlian
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Lu
authors.forename: Tatiana
authors.initials: T
authors.lastname: Segura
authors.forename: Xu-Bo
authors.initials: XB
authors.lastname: Yuan
authors.forename: Xianjin
authors.initials: X
authors.lastname: Yang
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lu
mesh_terms: D006046:Gold / Q000737:chemistry*; D049449:Luminescence; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D013056:Spectrophotometry, Ultraviolet
chemical_list: D006046:Gold
keywords: bioluminescent protein naocapsules; gold nanocrystal; intracellular delivery; metal-enhanced bioluminescence