title: ExportAid: database of RNA elements regulating nuclear RNA export in mammals.
abstract: BACKGROUND
  Regulation of nuclear mRNA export or retention is carried out by RNA elements but the mechanism is not yet well understood. To understand the mRNA export process, it is important to collect all the involved RNA elements and their trans-acting factors.
  
  
  RESULTS
  By hand-curated literature screening we collected, in ExportAid database, experimentally assessed data about RNA elements regulating nuclear export or retention of endogenous, heterologous or artificial RNAs in mammalian cells. This database could help to understand the RNA export language and to study the possible export efficiency alterations owing to mutations or polymorphisms. Currently, ExportAid stores 235 and 96 RNA elements, respectively, increasing and decreasing export efficiency, and 98 neutral assessed sequences.
  
  
  METHODS
  Freely accessible without registration at http://www.introni.it/ExportAid/ExportAid.html. Database and web interface are implemented in Perl, MySQL, Apache and JavaScript with all major browsers supported.
authors.affiliation: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Giulietti
authors.affiliation: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
authors.forename: Sara Armida
authors.initials: SA
authors.lastname: Milantoni
authors.affiliation: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Armeni
authors.affiliation: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Principato
authors.affiliation: Department of Specialistic Clinical and Odontostomatological Sciences, Polytechnic University of Marche, Ancona 60131, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Piva
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism*; D030561:Databases, Nucleic Acid; D006801:Humans; D008322:Mammals; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D015138:RNA, Nuclear / Q000235:genetics; D016601:RNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D015534:Trans-Activators
chemical_list: D015138:RNA, Nuclear; D016601:RNA-Binding Proteins; D015534:Trans-Activators; D012313:RNA