title: Efficacy of the local endometrial injury in patients who had previous failed IVF-ICSI outcome.
abstract: BACKGROUND
  The latest studies reported that local endometrial injury is a useful method to improve the success of IVF-ICSI outcome.
  
  
  OBJECTIVE
  To assess whether local endometrial injury occurred by Pipelle in the spontaneous cycle could improve implantation rate, cleavage rate, and pregnancy outcome in the subsequent IVF-ICSI cycle in patients who had recurrent IVF failure.
  
  
  METHODS
  An endometrial biopsy was performed on day 21(st) in 41 patients as intervention group in this retrospective cross-sectional study. The control group contained 42 women.
  
  
  RESULTS
  Implantation rate was 22.5% and 10.5% in intervention and control group, respectively and this difference was found to be statistically significant (p=001). Pregnancy rate was 43.9% in the intervention group and this parameter was significantly lower in control group (21.4%) (p=0.03).
  
  
  CONCLUSIONS
  Local endometrial injury in the nontransfer cycle increases the implantation rate and pregnancy rate in the subsequent IVF-ICSI cycle in patients who had previous failed IVF-ICSI outcome.
authors.affiliation: Department of Obstetrics and Gynecology, Bozok University, Medical Faculty, Yozgat, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kara
authors.affiliation: Department of Obstetrics and Gynecology, Kayseri In vitro Fertilization Center, Kayseri, Turkey.
authors.forename: Turgut
authors.initials: T
authors.lastname: Aydin
authors.affiliation: Department of Obstetrics and Gynecology, Kayseri In vitro Fertilization Center, Kayseri, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Turktekin
authors.affiliation: Department of Nuclear Medicine, Bozok University Medical Faculty, Yozgat, Turkey.
authors.forename: Karacavus
authors.initials: K
authors.lastname: S
keywords: Embryo transfer; In vitro fertilization; Local endometrial injury; Pregnancy