title: Study on overhydration in dialysis patients and its association with inflammation.
abstract: BACKGROUND
  &nbsp;Patients with chronic kidney disease receiving haemodialysis (HD) have permanent variations in hydration status that may affect their survival.&nbsp;
  
  
  OBJECTIVE
  &nbsp;To analyse hydration status and body composition in patients on haemodialysis and its relation to inflammation.&nbsp;
  
  
  METHODS
  &nbsp;We included 128 prevalent clinically stable patients on haemodialysis. We analysed body composition using spectroscopic bioimpedance and inflammation using blood parameters.&nbsp;
  
  
  RESULTS
  &nbsp;Patients with higher lean tissue had less intracellular (p=0.02) and extracellular water (p&nbsp;=&nbsp;0.001). We did not find association with fat tissue and hydration. Mean overhydration was 7.5&nbsp;%. We found an association between overhydration adjusted to extracellular water (OH/ECW) higher than 15&nbsp;% similar to 10&nbsp;%. They were both associated with low prealbumin levels (p&nbsp;=&nbsp;0.001 and p&nbsp;=&nbsp;0.05 respectively) and low levels of fat tissue (p&nbsp;=&nbsp;0.001 and p&nbsp;=&nbsp;0.05 respectively).&nbsp;
  
  
  CONCLUSIONS
  &nbsp;Overhydration defined as OH/ECW higher than 10&nbsp;% and 15&nbsp;% are related to low prealbumin levels and low fat tissue. We suggest decreasing the overhydration limit measured by bioimpedance to OH/ECW higher than 10&nbsp;%.
authors.forename: Almudena
authors.initials: A
authors.lastname: Vega
authors.forename: Borja
authors.initials: B
authors.lastname: Quiroga
authors.forename: Soraya
authors.initials: S
authors.lastname: Abad
authors.forename: Caridad
authors.initials: C
authors.lastname: Ruiz
authors.forename: Juan M
authors.initials: JM
authors.lastname: López-Gómez
mesh_terms: D000368:Aged; D001823:Body Composition; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications*; D008297:Male; D006435:Renal Dialysis; D014883:Water-Electrolyte Imbalance / Q000150:complications*