title: Effects of an aerobic exercise programme on fatigue for patients with breast cancer undergoing radiotherapy.
abstract: OBJECTIVE
  This study was designed to evaluate the efficacy of an aerobic exercise programme on fatigue for Taiwanese breast cancer women under radiotherapy (RT).
  
  
  BACKGROUND
  Cancer-related fatigue has been widely reported by patients undergoing radiotherapy as strongly and profoundly interfering with their quality of life. Evidence has shown that exercise can be beneficial to patients with breast cancer.
  
  
  METHODS
  A quasi-experimental design was used.
  
  
  METHODS
  Patients with early-stage breast cancer scheduled for radiotherapy were invited to participate. The first 28 women who agreed to participate were assigned to the intervention group with a six-week mild- to moderate-intensity aerobic exercise training programme during their radiotherapy. The next 30 women were assigned to the routine care control group without special exercise intervention. Fatigue was measured at pre-radiotherapy and weekly after starting radiotherapy for six weeks using the Taiwanese version of the Brief Fatigue Inventory.
  
  
  RESULTS
  The mean age of these 47 women was 50·3 years (standard deviation = 9·5). The baseline fatigue severity for the intervention group and control group were 3·04 and 2·95 respectively; and the baseline fatigue interference for the intervention group and the control group were 3·48 and 3·55 respectively. The student t-test showed no group differences in baseline fatigue severity, fatigue interference, or haemoglobin levels. Multivariate analyses showed a significant group-by-time-interaction effect for fatigue severity and interference (p ≦ 0·001); the fatigue severity and interference decreased significantly over time for women in the intervention group but increased over time for women in the control group.
  
  
  CONCLUSIONS
  The mild- to moderate-intensity aerobic exercise programme reduces the fatigue of Taiwanese women with breast cancer undergoing radiotherapy. The issues of cancer-related fatigue should also be discussed as they relate to other treatment modalities.
  
  
  CONCLUSIONS
  Aerobic exercise intervention should be offered as an option for women with breast cancer to alleviate cancer-related fatigue when undergoing radiotherapy.
authors.affiliation: Graduate Institute of Nursing, National Taipei University of Nursing and Health Science and Instructor School of Nursing, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
authors.forename: Tsui-Yun
authors.initials: TY
authors.lastname: Yang
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.forename: Chia-Chun
authors.initials: CC
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D015444:Exercise; D005221:Fatigue / Q000209:etiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D013624:Taiwan; D016896:Treatment Outcome
keywords: aerobic exercise; breast cancer; fatigue; radiotherapy