title: [Sensitization to laboratory animal allergens among students and researchers exposed to laboratory rodents in Hokkaido university].
abstract: BACKGROUND
  Based on a case who developed anaphylaxis after mouse bite which occurred at Hokkaido University, we studied on allergic sensitization prevalence for laboratory animals among students and researchers who are exposed to laboratory rodents and rabbit, for the purpose of allergy prevention, particularly anaphylaxis.
  
  
  METHODS
  We carried out the health check-up on laboratory animal allergy (LAA) by questionnaires and specific-IgE antibody test for 555 rodents and/or rabbit handlers from whom informed consent was obtained.
  
  
  RESULTS
  Prevalence of positive IgE antibody higher than class 1 to mice, rats, hamsters, guinea pigs, and/or rabbits in the examinees was 14.1% (62/441) , 17.9% (50/279) , 18.8% (6/32) , 17.4% (4/23) , and 11.3% (12/106) , respectively. Moreover, among users of mouse, those who had allergic symptoms during contact with animals resulted in significantly higher positive rate for anti-mouse IgE antibody test than the other (38.1% vs 8.8%, p<0.01) .
  
  
  CONCLUSIONS
  Health check-up including measurement of specific-IgE antibody against laboratory animals is useful for understanding allergic sensitization.
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshimura
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Manabu
authors.initials: M
authors.lastname: Musashi
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Takeaki
authors.initials: T
authors.lastname: Kaneko
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Ohnishi
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Chieko
authors.initials: C
authors.lastname: Orito
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Yukako
authors.initials: Y
authors.lastname: Kawahara
authors.affiliation: Health Care Center, Hokkaido University.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashino
authors.affiliation: Laboratory of Animal Experiment Institute for Genetic Medicine, Hokkaido University.
authors.forename: Masami
authors.initials: M
authors.lastname: Morimatsu
authors.affiliation: First Department of Internal Medicine, Hokkaido University Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Konno
authors.affiliation: Department of Microbiology, Graduate School of Medicine, Hokkaido University.
authors.forename: Jiro
authors.initials: J
authors.lastname: Arikawa
authors.affiliation: Office of Health and Safety, Hokkaido University.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ishii
authors.affiliation: Office of Health and Safety, Hokkaido University.
authors.forename: Masaya
authors.initials: M
authors.lastname: Sawamura
authors.affiliation: Office of Health and Safety, Hokkaido University.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ueda
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology*; D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D009784:Occupational Diseases / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects*; D012108:Research Personnel; D012377:Rodentia; D013334:Students
chemical_list: D000485:Allergens; D007073:Immunoglobulin E