title: Rare Association of Severe Cryptococcal and Tuberculosis in Central Nervous System in a case of Sarcoidosis.
abstract: Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis. Nonetheless, simultaneous association of CNS cryptococcosis and tuberculosis infection remains extremely rare event in immunocompetent states, and has not been reported in sarcoidosis yet. We here presented such a case in a 42 years old man, a known case of sarcoidosis with diagnostic and therapeutic difficulties were encountered in a fourteen-month-long hospitalization period.
authors.affiliation: 1. Resident of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. bsiroos@gmail.com.
authors.forename: Bahaadin
authors.initials: B
authors.lastname: Siroos
authors.affiliation: 2. Associated Professor of Infectious Disease, Imam Khomeini Hospital, Department of Infectious Disease, Tehran University of Medical Sciences, Tehran, Iran. ahmadiz@tums.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ahmadinejad
authors.affiliation: 3. Resident of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. motif42@gmail.com.
authors.forename: Mohamad
authors.initials: M
authors.lastname: Tabaeizadeh
authors.affiliation: 4. Resident of Infectious Disease, Imam Khomeini Hospital, Department of Infectious Disease, Tehran University of Medical Sciences, Tehran, Iran. newdrmy@yahoo.com.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Hedayat Yaghoobi
authors.affiliation: 5. Resident of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. abghsa@gmail.com.
authors.forename: Alireza
authors.initials: A
authors.lastname: Torabi
authors.affiliation: 6. Professor of Neurology, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. ghafarpour@sina.tums.ir.
authors.forename: Majid
authors.initials: M
authors.lastname: Ghaffarpour
keywords: Sarcoidosis; Tuberculosis; cryptococcosis; hydrocephalus; ventriculomeningitis