title: Exendin-4 effects on islet volume and number in the mouse pancreas.
abstract: The aim of this study was to evaluate Exendin-4 (EX-4) effect on islet volume and number in the mouse pancreas.Thirty-two healthy adult male NMRI mice were randomly divided into control and experimental groups. EX-4 was injected intraperitoneally (i. p.) at the doses of 0.25 (E1 group), 0.5 (E2 group), and 1 μg/kg (E3 group), twice a day for seven consecutive days. One day after the final injection, the mice were sacrificed, and pancreas from each animal was dissected out, weighed, and fixed in 10 % formalin for measurement of pancreas, and islet volume and islet number by stereological assessments. There was a significant increase in the weight of pancreases in E3 groups. Islet and pancreas volumes in E1 and E2 groups were not changed compared to control group. E3 group showed a significant increase in islet and pancreas volume (p < 0.05). There were no significant changes in the total number of islets in three experimental groups. The results revealed that EX-4 increased pancreas and islet volume in non-diabetic mice. The increased total islet mass is probably caused by islet hypertrophy without the formation of additional islets (Fig. 5, Ref. 35).
authors.forename: L
authors.initials: L
authors.lastname: Khorsandi
authors.forename: F
authors.initials: F
authors.lastname: Nejad-Dehbashi
mesh_terms: D000818:Animals; D002452:Cell Count; D048429:Cell Size / Q000187:drug effects; D000077270:Exenatide; D051272:Glucose Transporter Type 1 / Q000235:genetics / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000033:anatomy & histology; D010455:Peptides / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D014688:Venoms / Q000494:pharmacology*
chemical_list: D051272:Glucose Transporter Type 1; D007004:Hypoglycemic Agents; D007328:Insulin; D010455:Peptides; D012333:RNA, Messenger; D014688:Venoms; D000077270:Exenatide