title: Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage.
abstract: A graphene nano-cage with regulatable space for the assembly of a cytochrome P450 1A2-UDP-glucuronosyltransferase 1A10 bienzyme complex has been constructed via a click reaction, and successfully used to study drug sequential metabolism using an electrochemically-driven method.
authors.affiliation: Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China. liusq@seu.edu.cn.
authors.forename: Jusheng
authors.initials: J
authors.lastname: Lu
authors.forename: Yuanjian
authors.initials: Y
authors.lastname: Zhang
authors.forename: Henan
authors.initials: H
authors.lastname: Li
authors.forename: Jiachao
authors.initials: J
authors.lastname: Yu
authors.forename: Songqin
authors.initials: S
authors.lastname: Liu
mesh_terms: D019388:Cytochrome P-450 CYP1A2 / Q000737:chemistry / Q000378:metabolism*; D055664:Electrochemical Techniques; D014453:Glucuronosyltransferase / Q000737:chemistry / Q000378:metabolism*; D006108:Graphite / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations; D006108:Graphite; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; C476725:bilirubin uridine-diphosphoglucuronosyl transferase 1A10; D014453:Glucuronosyltransferase