title: CC chemokine receptor polymorphism CCR5Δ32 in Portuguese Behçet's disease patients.
abstract: OBJECTIVE
  To investigate whether CCR5 deletion is associated with susceptibility to Behçet's disease (BD) in a Portuguese population.
  
  
  METHODS
  A total of 122 BD patients and 227 ethnically-matched controls were studied. Genotyping of the CCR5Δ32 polymorphisms was performed using polymerase chain reaction product sizing.
  
  
  RESULTS
  No significant differences were observed in the allelic frequencies of CCR532 between patients and controls (OR=0.820; p=0.512). Stratification for gender and for the presence of HLA-B*51 did not reveal any significant differences.
  
  
  CONCLUSIONS
  These results indicate that CCR5Δ32 is unlikely to contribute to susceptibility to BD in Portuguese patients. This may be explained by the known functional redundancy of this signalling system.
authors.affiliation: UMIB, Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Porto, Portugal. ambettencourt@icbas.up.pt.
authors.forename: Andreia
authors.initials: A
authors.lastname: Bettencourt
authors.forename: Bárbara
authors.initials: B
authors.lastname: Leal
authors.forename: Cláudia
authors.initials: C
authors.lastname: Carvalho
authors.forename: Rita
authors.initials: R
authors.lastname: Oliveira
authors.forename: Ana
authors.initials: A
authors.lastname: Martins Silva
authors.forename: José
authors.initials: J
authors.lastname: Vaz Patto
authors.forename: Marina
authors.initials: M
authors.lastname: Bastos
authors.forename: Luciana
authors.initials: L
authors.lastname: Costa
authors.forename: Paulo P
authors.initials: PP
authors.lastname: Costa
authors.forename: Carlos
authors.initials: C
authors.lastname: Vasconcelos
authors.forename: João
authors.initials: J
authors.lastname: Correia
authors.forename: Berta M
authors.initials: BM
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000235:genetics* / Q000378:metabolism; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011174:Portugal; D019713:Receptors, CCR5 / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D055815:Young Adult
chemical_list: C584933:CCR5 protein, human; D019713:Receptors, CCR5