title: Managing menorrhagia in a familial case of factor V deficiency.
abstract: BACKGROUND
  Factor V deficiency is a rare coagulation disorder. Excessive uterine bleeding is common in affected women. We describe a case of 2 siblings with Factor V deficiency and menorrhagia who achieved control of bleeding with differing treatments.
  
  
  METHODS
  Patient 1 is a 16-year-old female with Factor V deficiency and menorrhagia which was previously controlled with oral contraceptives (OC). She developed heavy bleeding treated with fresh frozen plasma, anti-inhibitor coagulant complex (AICC), and OC taper. A levonorgestrel IUD was placed with good control of her menorrhagia. Patient 2 is the 12-year-old sister of Patient 1. She was treated with AICC, aminocaproic acid, and her menorrhagia was ultimately controlled with continuous OCs.
  
  
  CONCLUSIONS
  Factor V deficiency is a rare cause of menorrhagia. Various treatment modalities are available. In these adolescent sisters desiring future fertility, menorrhagia was managed with OCs and an IUD.
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL. Electronic address: michelle.stalnaker@jax.ufl.edu.
authors.forename: M
authors.initials: M
authors.lastname: Stalnaker
authors.affiliation: Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL.
authors.forename: P
authors.initials: P
authors.lastname: Esquivel
mesh_terms: D000293:Adolescent; D015119:Aminocaproic Acid / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D002648:Child; D003271:Contraceptive Agents, Female / Q000627:therapeutic use; D005166:Factor V Deficiency / Q000150:complications*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000627:therapeutic use; D008595:Menorrhagia / Q000188:drug therapy* / Q000209:etiology; D035781:Siblings
chemical_list: D000933:Antifibrinolytic Agents; D003271:Contraceptive Agents, Female; D016912:Levonorgestrel; D015119:Aminocaproic Acid
keywords: Factor V; Intrauterine devices; Menorrhagia; Oral contraceptives