title: Mycophenolic acid derivatives from cultures of the mushroom Laetiporus sulphureu.
abstract: OBJECTIVE
  To investigate the chemical constituents of the cultures of Laetiporus sulphureus (Bull.) Murrill.
  
  
  METHODS
  Compounds were isolated and purified by various chromatographic techniques. The structure of the new compound was determined by interpretation of MS and 1D-, 2D-NMR spectroscopic data, while the known compounds were identified by comparison of their data with those reported.
  
  
  RESULTS
  Three mycophenolic acid derivatives, 6-((2E, 6E)-3, 7-dimethyldeca-2, 6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (1), 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-5, 7-dihydroxy-4-methylphtanlan-1-one (2), and 6-((2E, 6E)-3, 7, 11-trimethyldedoca-2, 6, 10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one (3) were isolated.
  
  
  CONCLUSIONS
  Among them, compound 1 was new, and compound 2 exhibited moderate cytotoxicity against HL-60, SMMC-7721, A-549, and MCF-7 cells, with IC50 values of 39.1, 31.1, 27.4, and 35.7 μmol·L(-1), respectively.
authors.affiliation: College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.
authors.forename: Qiong-Ying
authors.initials: QY
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China; University of Chinese Academy of Sciences, Beijing 100049, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yin
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. Electronic address: fengtao@mail.kib.ac.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.affiliation: College of Life Science, Hebei Normal University, Shijiazhuang 050024, China. Electronic address: zhaobaohua86178@sohu.com.
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Zhao
mesh_terms: D000363:Agaricales; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D018922:HL-60 Cells; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D009369:Neoplasms / Q000188:drug therapy; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D020072:Polyporales / Q000737:chemistry*
chemical_list: C000598245:6-((2E,6E)-3,7,11-trimethyldedoca-2,6,10-trienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one; C000598244:6-((2E,6E)-3,7-dimethyldeca-2,6-dienyl)-7-hydroxy-5-methoxy-4-methylphtanlan-1-one; D001688:Biological Products; D010636:Phenols; D009173:Mycophenolic Acid
keywords: Cytotoxicity; Laetiporus sulphureus; Mycophenolic acid derivatives