title: Ovarian reserve in breast cancer: assessment with anti-Müllerian hormone.
abstract: Anti-Müllerian hormone (AMH) levels fall during chemotherapy. Treatment-induced amenorrhoea is a reversible phenomenon, but few data are available on long-term AMH changes in breast cancer. The aim of the study was to describe serum AMH levels before, during and in the long term after chemotherapy, and to show a potential AMH recovery. Between May 2010 and June 2011, we selected 134 women aged 18-43 years at the time of breast cancer diagnosis who received chemotherapy between 2005 and 2011, and had not undergone an oophorectomy or had previous cytotoxic treatment. The AMH levels were assessed before, during and 4 months to 5.5 years after the end of chemotherapy. During chemotherapy, AMH was undetectable in 69% of women. After chemotherapy, a significant increase in AMH was found, with an average magnitude of +1.2% per month (95% credibility interval: 0.7 to 1.6). Older age and 12 months of amenorrhoea were found to be associated with a lower AMH recovery rate, whereas baseline AMH and number of chemotherapy cycles were not. The process of AMH changes during and after chemotherapy is dynamic, and shows recovery after ovarian injury. Caution should be exercised in interpreting individual AMH assessment in this context.
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France. Electronic address: hamyannesophie@gmail.com.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Hamy
authors.affiliation: Hôtel Dieu, APHP, Centre d'épidémiologie clinique, 75004 Paris, France; Inserm, 75475 Paris Cedex 10, France.
authors.forename: Raphaël
authors.initials: R
authors.lastname: Porcher
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Cuvier
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Giacchetti
authors.affiliation: Service de Biologie Cellulaire, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Schlageter
authors.affiliation: Service de Biochimie Endocrinienne et Oncologique, UF de Nutrigénétique, Groupe Hospitalier Pitié Salpêtrière, AP-HP, 47-83 Bd de l'Hôpital, 75651 Paris Cedex 13, France; U872 INSERM Equipe 4, Différenciation Intestinale et Métabolisme Lipidique, 15 Rue de l'Ecole de Médecine 75006 Paris, France.
authors.forename: Christiane
authors.initials: C
authors.lastname: Coussieu
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Héloise
authors.initials: H
authors.lastname: Gronier
authors.affiliation: Service de Biochimie, Laboratoire des Urgences et Gardes, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Feugeas
authors.affiliation: Service de Biochimie, Laboratoire des Urgences et Gardes, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Nadir
authors.initials: N
authors.lastname: Adoui
authors.affiliation: Service de Biochimie Endocrinienne et Oncologique, UF de Nutrigénétique, Groupe Hospitalier Pitié Salpêtrière, AP-HP, 47-83 Bd de l'Hôpital, 75651 Paris Cedex 13, France; U872 INSERM Equipe 4, Différenciation Intestinale et Métabolisme Lipidique, 15 Rue de l'Ecole de Médecine 75006 Paris, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Lacorte
authors.affiliation: Service de Biologie de la Reproduction, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Université Paris VI, 47-83 Bd de l'Hôpital, 75651 Paris Cedex 13, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Poirot
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Habdous
authors.affiliation: Centre des Maladies du Sein, Hôpital Saint Louis, AP-HP, 1 Avenue Claude Vellefaux, 75010, Paris, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Espié
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced; D054304:Anti-Mullerian Hormone / Q000097:blood*; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects; D065851:Ovarian Reserve / Q000187:drug effects*; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D054304:Anti-Mullerian Hormone
keywords: AMH; breast cancer; chemotherapy; ovarian reserve