title: Association between NOD2 single nucleotide polymorphisms and Grade III-IV acute graft-versus-host disease: A meta-analysis.
abstract: Objectives The effects of NOD2 single nucleotide polymorphisms (SNPs) on Grade III-IV acute graft-versus-host disease (aGVHD) risk are somewhat contradictory in different studies. The aim of the meta-analysis was to clarify the effects of NOD2 SNPs on the incidence of Grade III-IV aGVHD. Methods We searched PubMed, EMBASE, Web of SCIENCE, WanFang and Chinese National Knowledge Infrastructure (CNKI) databases to collect eligible publications. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association between NOD2 polymorphisms and Grade III-IV aGVHD risk. Results A total of nine studies from eight publications met the inclusion criteria and were included in this meta-analysis. Patient NOD2 SNPs were not associated with aGVHD risk. A tendency of higher risk to develop Grade III-IV aGVHD was found in patients with pairs NOD2 SNPs. Subgroup analyses showed that pairs NOD2 SNPs were associated with Grade III-IV aGVHD in the Caucasian population and in identical sibling donors (IS), but not in matched unrelated donors (MUD). In patients who received hematopoietic stem cell transplantation (HSCT) with T-cell depletion and gut decontamination, there was still an association between pairs NOD2 SNPs and Grade III-IV aGVHD risk. Conclusions Our meta-analysis suggests that pairs NOD2 SNPs, not patient NOD2 SNPs, may be associated with Grade III-IV aGVHD risk, especially in the Caucasian population. It is also indicated that in pairs NOD2 polymorphisms group, patients who receive HSCT from IS may experience higher risk of Grade III-IV aGVHD.
authors.forename: Haizhao
authors.initials: H
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Jia
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Cheng
authors.forename: Zebin
authors.initials: Z
authors.lastname: Luo
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xu
authors.forename: Shilong
authors.initials: S
authors.lastname: Yang
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Tang
mesh_terms: D020022:Genetic Predisposition to Disease; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology* / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008212:Lymphocyte Depletion; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011292:Premedication; D012720:Severity of Illness Index; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: Acute graft-versus-host disease; Meta-analysis; NOD2; Risk; Single nucleotide polymorphisms