title: Unrelated donor HLA re-typing effort to verify prevalence of newer alleles: HLA-A*24:23, A*30:10, DRB1*08:11, DRB1*15:03, and DRB1*15:06.
abstract: The National Marrow Donor Program (NMDP) is committed to maintaining accurate human leukocyte antigen (HLA) data for each of the 11.5 million volunteer donors on the Be The Match Registry(®) . Qualitative data analysis identified five population specific alleles suspect of being incorrectly characterized. Alleles evaluated were HLA-A*24:03 for the presence of A*24:23 in Native Americans, A*30:02 for the presence of A*30:10 when B*41 and DRB1*04:05 were in the haplotype, DRB1*08:02 for the presence of DRB1*08:11 in Native Americans, and DRB1*15:01 for the presence of DRB1*15:03 in African Americans or DRB1*15:06 in Asian donors. Discrepancy rate was 55%, 86%, 31%, 75%, and 13%, respectively. Utilizing the HLA typing date, race, and date an allele in question was described may provide a selection strategy leading to the consideration of additional unrelated donors for searching patients.
authors.affiliation: National Marrow Donor Program, Scientific Services, Minneapolis, MN, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kempenich
authors.forename: J
authors.initials: J
authors.lastname: Dehn
authors.forename: G
authors.initials: G
authors.lastname: Flickinger
authors.forename: M
authors.initials: M
authors.lastname: Setterholm
mesh_terms: D000483:Alleles; D030561:Databases, Nucleic Acid; D046148:Donor Selection; D005260:Female; D015234:HLA-A Antigens / Q000235:genetics*; D059871:HLA-A24 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008824:Michigan; D012042:Registries; D061349:Unrelated Donors
chemical_list: D015234:HLA-A Antigens; C069526:HLA-A*30 antigen; D059871:HLA-A24 Antigen; D059811:HLA-DRB1 Chains
keywords: HLA-A; HLA-DRB1; allele prevalence; sequence-based typing; stem cell; transplantation