title: Joiner et al. reply.
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: Mei-Ling A
authors.initials: ML
authors.lastname: Joiner
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Olha M
authors.initials: OM
authors.lastname: Koval
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: B Julie
authors.initials: BJ
authors.lastname: He
authors.affiliation: University of Iowa Central Microscopy Research Facility, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Chantal
authors.initials: C
authors.lastname: Allamargot
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Gao
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: Elizabeth D
authors.initials: ED
authors.lastname: Luczak
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Duane D
authors.initials: DD
authors.lastname: Hall
authors.affiliation: Iowa City Veterans Affairs Medical, Iowa City, Iowa 52246, USA.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Fink
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Biyi
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Jinying
authors.initials: J
authors.lastname: Yang
authors.affiliation: 1] Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Moore
authors.affiliation: Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Scholz
authors.affiliation: Department of Pharmacology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Stefan
authors.initials: S
authors.lastname: Strack
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Mohler
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Iowa City Veterans Affairs Medical, Iowa City, Iowa 52246, USA.
authors.forename: William I
authors.initials: WI
authors.lastname: Sivitz
authors.affiliation: Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Long-Sheng
authors.initials: LS
authors.lastname: Song
authors.affiliation: 1] Department of Internal Medicine and Cardiovascular Center, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [2] Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA [3] Department of Molecular Physiology &Biophysics, Carver College of Medicine, University of Iowa, 51 Newton Road, Iowa City, Iowa 52242, USA (M.A.J.); The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA (J.L., P.J.M.); Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA (B.J.H.); Johns Hopkins University School of Medicine, 1830 East Monument Street, 9th Floor, Suite 9026, Baltimore, Maryland 21287, USA (E.D.L., M.E.A.).
authors.forename: Mark E
authors.initials: ME
authors.lastname: Anderson
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D005260:Female; D008929:Mitochondria, Heart / Q000378:metabolism* / Q000473:pathology*; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology*; D013312:Stress, Physiological
chemical_list: D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D002118:Calcium