title: Carbimazole inhibits TNF-α expression in Fat-induced hypothyroidism.
abstract: The effect of the carbimazole on expression of tumor necrosis factor (TNF-α) in liver, was investigated in an experimental model of high fat diet (HFD) induced obesity. The HFD (orally given for 4 months) induced TNF-α in liver tissue along with raised serum triglyceride (TG), cholesterol and high TSH (62%). In carbimazole (1 mg/100 gbw) treatment, the induction of TNF-α was significantly inhibited, without affecting other parameters. It also improved the liver function, which was raised due to HFD in experimental control rats.
authors.affiliation: Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.
authors.forename: Yamani Bhusan
authors.initials: YB
authors.lastname: Tripathi
authors.affiliation: Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005 India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Pandey
keywords: Carbimazole; High fat diet; Obesity; TNF-α