title: The coaction of tonic and phasic dopamine dynamics.
abstract: Tonic neurochemical dopamine activity underlies many brain functions; however a consensus on this important concentration has not yet been reached. In this work, we introduce in vivo fast-scan controlled-adsorption voltammetry to report tonic dopamine concentrations (90 ± 9 nM) and the dopamine diffusion coefficient (1.05 ± 0.09 × 10(-6) cm(2) s(-1)) in the mouse brain.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, AZ 85721, USA. mheien@arizona.edu.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Atcherley
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Wood
authors.forename: Kate L
authors.initials: KL
authors.lastname: Parent
authors.forename: Parastoo
authors.initials: P
authors.lastname: Hashemi
authors.forename: Michael L
authors.initials: ML
authors.lastname: Heien
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000737:chemistry / Q000378:metabolism; D000327:Adsorption; D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000737:chemistry / Q000378:metabolism*; D055664:Electrochemical Techniques; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D008995:Monoamine Oxidase; D001205:Ascorbic Acid; D004298:Dopamine