title: Metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component causing diagnostic challenges.
abstract: BACKGROUND
  Breast metastasis from extramammary malignancy is uncommon and often presents diagnostic challenges. Herein, we report a case of a patient with metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component.
  
  
  METHODS
  A 47-year-old woman presented with left breast nodule detected on a screening breast ultrasonography. She had surgery for pulmonary adenocarcinoma 3 years ago, and was disease-free state in the follow up studies. The patient was diagnosed with invasive micropapillary carcinoma of the breast by core needle biopsy. She underwent left breast lumpectomy and sentinel lymph node biopsy, and the histologic findings revealed micropapillary carcinoma. Based on the immunohistochemical study, the final diagnosis was solitary breast metastasis from pulmonary adenocarcinoma with micropapillary component.
  
  
  CONCLUSIONS
  The diagnosis of metastasis to the breast from extramammary malignancies is difficult but important for proper management and prediction of prognosis. A careful clinical history with a thorough clinical examination is needed to make the correct diagnosis.
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Jeong
authors.forename: Jin Gu
authors.initials: JG
authors.lastname: Bong
authors.forename: Hoon Kyu
authors.initials: HK
authors.lastname: Oh
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Park
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Kang
authors.affiliation: Department of Internal Medicine, Catholic University of Daegu School of Medicine, (705-718) 33, Duryugongwon-ro 17-gil, Nam-gu, Daegu, Korea. sunghwa@cu.ac.kr.
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Bae
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary*; D008875:Middle Aged; D021701:Sentinel Lymph Node Biopsy
chemical_list: C512478:EGFR protein, human; D066246:ErbB Receptors