title: Electric field regulated signaling pathways.
abstract: Physiological electric field (EF) is a potent guidance cue for many physiological development and pathological conditions. The EF induced cellular responses such as migration and proliferation, are considered to be regulated by multiple signaling pathways in a coordinated way. Unlike the signaling transduction regulating the cellular responses toward chemical gradients, the signaling network involved in electric stimulation shows a unique manner, combining the regulation of ion channels, membrane receptors and associated intracellular signaling pathways. This review shall discuss the cellular responses in EF, and summarize the primary signaling network activated during the EF-induced cellular response.
authors.affiliation: Cardiff Institute of Tissue Engineering & Repair, School of Dentistry, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Cardiff Institute of Tissue Engineering & Repair, School of Dentistry, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom. Electronic address: SongB3@cardiff.ac.uk.
authors.forename: Bing
authors.initials: B
authors.lastname: Song
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D008954:Models, Biological; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007473:Ion Channels; D011956:Receptors, Cell Surface; D019869:Phosphatidylinositol 3-Kinases; D020928:Mitogen-Activated Protein Kinases; D051059:PTEN Phosphohydrolase
keywords: AChR and NMDAR; EGFR; Electric field; Electrotaxis; MAPK; PI3K/Akt; PTEN