title: [Value of different biochemical markers in early diagnosis of acute myocardial infarction].
abstract: OBJECTIVE
  To study the value of the biochemical markers heart fatty acid binding protein (H-FABP), creatine kinase isoenzyme-MB (CK-MB), myocardial troponin T (cTnT) in early diagnosis of acute myocardial infarction (AMI).
  
  
  METHODS
  Serum levels of H-FABP, CK-MB, and cTNT were detected in 95 patients with confirmed AMI at different time points following the onset in comparison with the data from 43 patients without AMI. The sensitivity and specificity of H-FABP in different phases following the onset were compared between those of CK-MB and cTnT.
  
  
  RESULTS
  Serum H-FABP activities increased significantly within 3 h after the onset of AMI (P<0.01) and continued to increase at 3-6 h and 6-12 h (P<0.001). Serum level of CK-MB within 6 h and cTnT level within 3 h after AMI onset did not show obvious changes (P<0.05). Both the diagnostic sensitivity and specificity of H-FABP within 3 h and within 3-6 h were higher than those CK-MB and cTnT (P<0.05).
  
  
  CONCLUSIONS
  H-FABP is superior to CK-MB and cTnT in early diagnosis (within 3 h and 3-6 h following the onset) of AMI.
authors.affiliation: Department of Cardiology, Fourth Affiliated Hospital, Medical College of Jinan University, Guangzhou Red-Cross Hospital, Guangzhou 510220, China. E-mail: yarongdoc@163.com.
authors.forename: Yarong
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhuangbo
authors.initials: Z
authors.lastname: Guo
authors.forename: Liping
authors.initials: L
authors.lastname: Huang
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood; D042241:Early Diagnosis; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T; D052279:Creatine Kinase, MB Form