title: WildCARDs: inflammatory caspases directly detect LPS.
abstract: Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.
authors.affiliation: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Jon Alan
authors.initials: JA
authors.lastname: Hagar
authors.affiliation: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Aachoui
authors.affiliation: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Edward Axel
authors.initials: EA
authors.lastname: Miao
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism*; D053471:Caspases, Initiator / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008070:Lipopolysaccharides / Q000378:metabolism*
chemical_list: D008070:Lipopolysaccharides; D020169:Caspases; D053471:Caspases, Initiator