title: [Transdisciplinary Approach for Sarcopenia. Appication of selective androgen receptor modulator to the therapy of sarcopenia].
abstract: The research to develop a drug, so called selective androgen receptor modulator (SARM) , which shows beneficial androgenic action on bone and muscle, but hardly possesses the stimulatory action on prostate has been making a progress. However, no drug is available in the market at present. Most of such drugs are developed, aiming at the application to age-related muscle reduction (sarcopenia) and osteoporosis. Recently, in a clinical trial of SARM (enbosarm) administration to healthy elderly men, a promising data showing the increase of lean body mass and physical function has been reported. Future clinical applications of SARMs are expected.
authors.affiliation: Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yanase
authors.forename: Makito
authors.initials: M
authors.lastname: Tanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Nomiyama
mesh_terms: D000375:Aging; D005081:Exercise Therapy; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism*; D055948:Sarcopenia / Q000188:drug therapy* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen; D013739:Testosterone