title: [Transdisciplinary Approach for Sarcopenia. Clinical significance of sarcopenia in the patients with chronic liver disease].
abstract: Recently, many studies of the patients with chronic liver disease have focused on sarcopenia. In the patients with chronic liver disease, sarcopenia occurs, because of advanced liver failure and hepatocellular carcinoma (HCC) . In both diseases, sarcopenia is an important prognostic factor. Thus, sarcopenia has been reported to be a predictor for recurrence of HCC and early mortality after liver transplantation. In the patients with HCC, the mechanism of sarcopenia is unknown. In the patients with endostea liver failure, muscle compensates energy breakdown of the liver and muscle atrophy occurs. Further research is necessary to clarify whether nutritional support and muscle training prevent from sarcopenia and as a result, improve survival of the patients with chronic liver disease.
authors.affiliation: Department of Surgery and Science, Kyushu University, Fukuoka, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shirabe
authors.forename: Norifumi
authors.initials: N
authors.lastname: Harimoto
authors.forename: Toru
authors.initials: T
authors.lastname: Ikegami
authors.forename: Tomoharu
authors.initials: T
authors.lastname: Yoshizumi
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoh
authors.forename: Kazuki
authors.initials: K
authors.lastname: Takeishi
authors.forename: Takeo
authors.initials: T
authors.lastname: Toshima
authors.forename: Kohichi
authors.initials: K
authors.lastname: Kimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Bekki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Imai
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Kawanaka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Maehara
mesh_terms: D002908:Chronic Disease; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D011379:Prognosis; D055948:Sarcopenia / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism