title: Platinum(II)-gadolinium(III) complexes as potential single-molecular theranostic agents for cancer treatment.
abstract: Theranostic agents are emerging multifunctional molecules capable of simultaneous therapy and diagnosis of diseases. We found that platinum(II)-gadolinium(III) complexes with the formula [{Pt(NH3)2Cl}2GdL](NO3)2 possess such properties. The Gd center is stable in solution and the cytoplasm, whereas the Pt centers undergo ligand substitution in cancer cells. The Pt units interact with DNA and significantly promote the cellular uptake of Gd complexes. The cytotoxicity of the Pt-Gd complexes is comparable to that of cisplatin at high concentrations (≥0.1 mM), and their proton relaxivity is higher than that of the commercial magnetic resonance imaging (MRI) contrast agent Gd-DTPA. T1-weighted MRI on B6 mice demonstrated that these complexes can reveal the accumulation of platinum drugs in vivo. Their cytotoxicity and imaging capabilities make the Pt-Gd complexes promising theranostic agents for cancer treatment.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P. R. China).
authors.forename: Zhenzhu
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
authors.forename: Tuanjie
authors.initials: T
authors.lastname: Li
authors.forename: Silvio
authors.initials: S
authors.lastname: Aime
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
authors.forename: Zijian
authors.initials: Z
authors.lastname: Guo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy*; D010984:Platinum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010984:Platinum; D005682:Gadolinium
keywords: antitumor agents; gadolinium; imaging agents; platinum; theranostic agents