title: Resveratrol inhibits sodium/iodide symporter gene expression and function in rat thyroid cells.
abstract: Resveratrol is a polyphenol found in grapes and berries that has antioxidant, antiproliferative and anti-inflammatory properties. For these reasons, it is available as a dietary supplement, and it is under investigation in several clinical trials. Few data are available regarding the effects of resveratrol on thyroid function. A previous study showed that resveratrol transiently increases iodide influx in FRTL-5 rat thyroid cells. Indeed, this increase arises after short treatment times (6-12 h), and no further effects are seen after 24 h. The aim of the present study was to investigate the effects of resveratrol on iodide uptake and sodium/iodide symporter expression in thyroid cells after longer times of treatment. For this purpose, the effects of resveratrol were evaluated both in vitro and in vivo using the rat thyroid FRTL-5 cell line and Sprague-Dawley rats, respectively. In FRTL-5 cells, resveratrol decreased the sodium/iodide symporter RNA and protein expression as a function of time. Furthermore, resveratrol decreased cellular iodide uptake after 48 h of treatment. The inhibitory effect of resveratrol on iodide uptake was confirmed in vivo in Sprague-Dawley rats. This study demonstrates that with longer-term treatment, resveratrol is an inhibitor of sodium/iodide symporter gene expression and function in the thyroid. These data suggest that resveratrol can act as a thyroid disruptor, which indicates the need for caution as a supplement and in therapeutic use.
authors.affiliation: Unit of Endocrinology, Department of Medicine and Sciences of Aging, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Cesidio
authors.initials: C
authors.lastname: Giuliani
authors.affiliation: Unit of Endocrinology, Department of Medicine and Sciences of Aging, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Ines
authors.initials: I
authors.lastname: Bucci
authors.affiliation: Unit of Endocrinology, Department of Medicine and Sciences of Aging, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Di Santo
authors.affiliation: Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Cosmo
authors.initials: C
authors.lastname: Rossi
authors.affiliation: Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy; Department of Oncology and Neurosciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Grassadonia
authors.affiliation: Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Mariotti
authors.affiliation: Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy; Department of Oncology and Neurosciences, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy.
authors.forename: Mauro
authors.initials: M
authors.lastname: Piantelli
authors.affiliation: Unit of Endocrinology, Department of Medicine and Sciences of Aging, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Monaco
authors.affiliation: Unit of Endocrinology, Department of Medicine and Sciences of Aging, "G. D'Annunzio" University of Chieti-Pescara, Chieti, Italy; Aging Research Centre (Ce.S.I.), "G. D'Annunzio" University Foundation, Chieti, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Napolitano
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002460:Cell Line; D015536:Down-Regulation / Q000187:drug effects*; D007454:Iodides / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077185:Resveratrol; D012964:Sodium / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*; D027981:Symporters / Q000037:antagonists & inhibitors* / Q000235:genetics* / Q000378:metabolism; D013961:Thyroid Gland / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D000099209:Sodium-Iodide Symporters
chemical_list: D000975:Antioxidants; D007454:Iodides; D000077185:Resveratrol; D012964:Sodium; D013267:Stilbenes; D027981:Symporters; D000099209:Sodium-Iodide Symporters