title: A new method using xenogeneicacellular dermal matrix in the reconstruction of lacrimal drainage.
abstract: OBJECTIVE
  To prospectively evaluate the reliability and efficacy of a new treatment for the reconstruction of the lacrimal duct using a new histo-engineered material, xenogeneic (bovine) acellular dermal matrix.
  
  
  METHODS
  Five patients (five eyes) with partial or total absence of the lacrimal duct were included in the study. Four patients (four eyes) suffered from traumatic injuries to the lacrimal duct and one patient (one eye) had congenital absence of the lacrimal drainage system. A pedal graft of conjunctiva was taken from the fornix area and rolled into a tube structure after being attached to the acellular dermal matrix.
  
  
  RESULTS
  The average duration of follow-up for the patients was 7.2 months (ranging from 6 to 12 months). After surgery, the new duct in the nasal cavity could be observed above the middle turbinate by nasal endoscopy. Patency was confirmed by pressing in the area of the lacrimal sac and visualising air bubbles in the nasal cavity. Additionally, the meatus above the middle turbinate of the nasal cavity was stained and visualised after patients underwent Jones dye test 1 (JDT1). Five tear ducts proved to be effective through irrigation testing and epiphora symptoms were alleviated in all cases.
  
  
  CONCLUSIONS
  The newly reconstructed lacrimal duct, formed by the shift of autogenous conjunctival petal and the attachment of acellular dermal matrix, was successful in all five cases and suggests a new solution for the complex lacrimal duct lesion and congenital anomalies of the lacrimal duct.
authors.affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Gong
authors.affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China.
authors.forename: Zhengzheng
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Department of Ophthalmology, University of Oklahoma, Dean McGee Eye Institute, Oklahoma City, OK, USA.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Jetton
authors.affiliation: School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China Sichuan Key Laboratory for Disease Gene Study, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Qu
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000818:Animals; D002417:Cattle; D002648:Child; D003228:Conjunctiva / Q000637:transplantation; D005124:Eye Abnormalities / Q000601:surgery*; D005131:Eye Injuries / Q000601:surgery*; D005260:Female; D064593:Heterografts; D006801:Humans; D008297:Male; D009301:Nasolacrimal Duct / Q000002:abnormalities* / Q000293:injuries*; D011446:Prospective Studies; D019651:Plastic Surgery Procedures; D023822:Tissue Engineering; D055815:Young Adult
keywords: Graft; Lacrimal duct