title: Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides.
abstract: The efficient asymmetric synthesis of unnatural alkenyl amino acids required for peptide 'stapling' has been achieved using alkylation of a fluorine-modified Ni(II) Schiff base complex as the key step.
authors.affiliation: Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK. andrew.jamieson@le.ac.uk.
authors.forename: Boris
authors.initials: B
authors.lastname: Aillard
authors.forename: Naomi S
authors.initials: NS
authors.lastname: Robertson
authors.forename: Adam R
authors.initials: AR
authors.lastname: Baldwin
authors.forename: Siobhan
authors.initials: S
authors.lastname: Robins
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Jamieson
mesh_terms: D000478:Alkylation; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D002413:Cations, Divalent; D018360:Crystallography, X-Ray; D005461:Fluorine / Q000737:chemistry*; D054879:Halogenation; D018716:Molecular Mimicry; D009532:Nickel / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D057786:Peptidomimetics / Q000138:chemical synthesis*; D017433:Protein Structure, Secondary; D012545:Schiff Bases / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002413:Cations, Divalent; D010455:Peptides; D057786:Peptidomimetics; D012545:Schiff Bases; D005461:Fluorine; D009532:Nickel