title: The CXCL12 G801A polymorphism is associated with cancer risk: a meta-analysis.
abstract: BACKGROUND
  CXCL12 is a small chemotactic cytokine belonging to the CXC chemokine family expressed in various organs. It contributes to the migration, invasion and angiogenesis of cancer cells. Recently, the CXCL12 G801A polymorphism was shown to be associated with an increased risk of various kinds of cancers, but the results were too inconsistent to be conclusive.
  
  
  METHODS
  To solve the problem of inadequate statistical power and conflicting results, a meta-analysis of published case-control studies was performed, including 4,435 cancer cases and 6,898 controls. Odds ratios (ORs) and their 95% confidence intervals (CIs) were used to determine the strength of association between CXCL12 G801A polymorphism and cancer risk.
  
  
  RESULTS
  A significant association between CXCL12 G801A polymorphism and cancer risk was found under all genetic models. Further, subgroup analysis stratified by ethnicity suggested a significant association between CXCL12 G801A polymorphism and cancer risk in the Asian subgroup under all genetic models. However, in the Caucasian subgroup, a significant association was only found under an additive genetic model and a dominant genetic model. The analysis stratified by cancer type found that CXCL12 G801A polymorphism may increase the risk of breast cancer, lung cancer, and "other" cancers. Based on subgroup stratified by source of controls, a significant association was observed in hospital-based studies under all genetic models.
  
  
  CONCLUSIONS
  The CXCL12 G801A polymorphism is associated with an increased risk of cancer based on current published data. In the future, large-scale well-designed studies with more information are needed to better estimate possible gene-gene or gene-environment interactions.
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zhu
authors.affiliation: Department of General Surgery, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Benchun
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Hu
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hematology, Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Zhuogang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D044466:Asian People; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D015870:Gene Expression; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12