title: Hierarchical assembly of branched supramolecular polymers from (cyclic Peptide)-polymer conjugates.
abstract: We report the synthesis and assembly of (N-methylated cyclic peptide)-polymer conjugates for which the cyclic peptide is attached to either the α- or both α- and ω- end groups of a polymer. A combination of chromatographic, spectroscopic, and scattering techniques reveals that the assembly of the conjugates follows a two-level hierarchy, initially driven by H-bond formation between two N-methylated cyclic peptides, followed by unspecific, noncovalent aggregation of this peptide into small domains that behave as branching points and lead to the formation of branched supramolecular polymers.
authors.affiliation: Key Centre for Polymers and Colloids, School of Chemistry, and ‡School of Chemistry, University of Sydney , Building F11, Sydney, New South Wales 2006, Australia.
authors.forename: Ming Liang
authors.initials: ML
authors.lastname: Koh
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Jolliffe
authors.forename: Sébastien
authors.initials: S
authors.lastname: Perrier
mesh_terms: D046911:Macromolecular Substances / Q000138:chemical synthesis; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D011108:Polymers / Q000138:chemical synthesis*
chemical_list: D046911:Macromolecular Substances; D010456:Peptides, Cyclic; D011108:Polymers