title: Anomalies in network bridges involved in bile Acid metabolism predict outcomes of colorectal cancer patients.
abstract: Biomarkers prognostic for colorectal cancer (CRC) would be highly desirable in clinical practice. Proteins that regulate bile acid (BA) homeostasis, by linking metabolic sensors and metabolic enzymes, also called bridge proteins, may be reliable prognostic biomarkers for CRC. Based on a devised metric, "bridgeness," we identified bridge proteins involved in the regulation of BA homeostasis and identified their prognostic potentials. The expression patterns of these bridge proteins could distinguish between normal and diseased tissues, suggesting that these proteins are associated with CRC pathogenesis. Using a supervised classification system, we found that these bridge proteins were reproducibly prognostic, with high prognostic ability compared to other known markers.
authors.affiliation: Department of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Sunjae
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Medical Informatics, School of Medicine, Ajou University, Yeongtong-gu, Suwon-si, Republic of Korea.
authors.forename: KiYoung
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Seyeol
authors.initials: S
authors.lastname: Yoon
authors.affiliation: Neuroscience Section, Papé Family Pediatric Research Institute, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, United States of America.
authors.forename: Jae W
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Doheon
authors.initials: D
authors.lastname: Lee
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism*; D014408:Biomarkers, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D063868:Patient Outcome Assessment; D011379:Prognosis; D025941:Protein Interaction Mapping; D040901:Proteomics; D015203:Reproducibility of Results
chemical_list: D001647:Bile Acids and Salts; D014408:Biomarkers, Tumor