title: Cardiac stem cell niches.
abstract: The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches represent specialized microdomains where the quiescent and activated state of resident stem cells is regulated. Alterations in niche function with aging and cardiac diseases result in abnormal sites of cardiomyogenesis and inadequate myocyte formation. The relevance of Notch1 signaling, gap-junction formation, HIF-1α and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed.
authors.affiliation: Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: aleri@partners.org.
authors.forename: Annarosa
authors.initials: A
authors.lastname: Leri
authors.affiliation: Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Marcello
authors.initials: M
authors.lastname: Rota
authors.affiliation: Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Toru
authors.initials: T
authors.lastname: Hosoda
authors.affiliation: Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Polina
authors.initials: P
authors.lastname: Goichberg
authors.affiliation: Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: panversa@partners.org.
authors.forename: Piero
authors.initials: P
authors.lastname: Anversa
mesh_terms: D000818:Animals; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D055153:Stem Cell Niche; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism