title: The role of TNF inhibitors in psoriatic disease.
abstract: In contrast to many other diseases, modern psoriasis therapy has a fairly brief history. Until about 15 years ago, clinicians and their patients had few options, with limited ability to rein in the disease process.The success of antifolate methotrexate in the treatment of rheumatoid arthritis (RA) led to clinical evaluation and adoption of the agent, a principal form of treatment for psoriasis, which, like RA, has its origin based in inflammation. The introduction of tumor necrosis factor-α inhibitors marked the beginning of the biologic era of psoriasis therapy. Also borrowed from the field of rheumatology, biologic therapy has evolved from improved understanding of the molecular basis of the disease process. An increased recognition of comorbid conditions that often accompany psoriasis, particularly psoriatic arthritis, can complicate clinical management. Dermatologists and other clinicians who treat psoriasis continue to benefit from insights gained in the field of rheumatology.
authors.affiliation: Professor and Chairman of Medicine, Department of Rheumatic and Immunologic Diseases, The Cleveland Clinic, Cleveland, OH.
authors.forename: Brian F
authors.initials: BF
authors.lastname: Mandell
authors.affiliation: Assistant Professor of Dermatology, Tufts School of Medicine; Director, Psoriasis Treatment Center, Skincare Physicians, Chestnut Hill, MA.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Sobell
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000188:drug therapy; D015897:Comorbidity; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D011565:Psoriasis / Q000188:drug therapy* / Q000453:epidemiology; D018124:Receptors, Tumor Necrosis Factor / Q000037:antagonists & inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D018501:Antirheumatic Agents; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D008727:Methotrexate
keywords: cardiovascular disease; methotrexate; obesity; psoriasis; psoriatic arthritis; psoriatic diseases; rheumatologic diseases; tumor necrosis factor inhibitors