title: Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial.
abstract: OBJECTIVE
  Anorexia nervosa (AN) is a serious disorder with high rates of morbidity and mortality. Family-based treatment (FBT) is an evidence-based therapy for adolescent AN, but less than half of those who receive this approach recover. Hence, it is important to identify other approaches to prevent the development of the chronic form of AN for which there is no known evidence-based treatment.
  
  
  OBJECTIVE
  To compare FBT with systemic family therapy (SyFT) for the treatment of adolescent-onset AN.
  
  
  METHODS
  Research in Anorexia Nervosa (RIAN) is a 2-group (FBT and SyFT) randomized trial conducted between September 2005 and April 2012. Interviewers were blinded to the treatment condition. A total of 564 adolescents receiving care at 6 outpatient clinics experienced in the treatment of AN were screened. Of these, 262 adolescents did not meet the inclusion criteria and 138 declined to participate; hence, 164 adolescents (aged 12-18 years) of both sexes meeting the criteria for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, AN (except for amenorrhea) were enrolled. Three participants were withdrawn from FBT and 7 were withdrawn from SyFT after serious adverse events occurred.
  
  
  METHODS
  Two manualized family therapies with 16 one-hour sessions during 9 months. Family-based therapy focuses on the facilitation of weight gain, whereas SyFT addresses general family processes.
  
  
  METHODS
  The primary outcomes were percentage of ideal body weight (IBW) and remission (≥95% of IBW). The a priori hypothesis was that FBT would result in faster weight gain early in treatment and at the end of treatment (EOT).
  
  
  RESULTS
  There were no statistically significant differences between treatment groups for the primary outcome, for eating disorder symptoms or comorbid psychiatric disorders at the EOT or follow-up. Remission rates included FBT, 33.1% at the EOT and 40.7% at follow-up and SyFT, 25.3% and 39.0%, respectively. Family-based therapy led to significantly faster weight gain early in treatment, significantly fewer days in the hospital, and lower treatment costs per patient in remission at the EOT (FBT, $8963; SyFT, $18 005). An exploratory moderator analysis found that SyFT led to greater weight gain than did FBT for participants with more severe obsessive-compulsive symptoms.
  
  
  CONCLUSIONS
  The findings of this study suggest that FBT is the preferred treatment for adolescent AN because it is not significantly different from SyFT and leads to similar outcomes at a lower cost than SyFT. Adolescents with more severe obsessive-compulsive symptoms may receive more benefits with SyFT.
  
  
  BACKGROUND
  clinicaltrials.gov Identifier NCT00610753.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
authors.forename: W Stewart
authors.initials: WS
authors.lastname: Agras
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
authors.forename: James
authors.initials: J
authors.lastname: Lock
authors.affiliation: Sheppard Pratt Health System, Baltimore, Maryland.
authors.forename: Harry
authors.initials: H
authors.lastname: Brandt
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
authors.forename: Susan W
authors.initials: SW
authors.lastname: Bryson
authors.affiliation: Department of Psychological Medicine, University of Otago, Otago, New Zealand.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Dodge
authors.affiliation: Department of Psychiatry, Weill Medical College, Cornell University, New York, New York.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Halmi
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.
authors.forename: Booil
authors.initials: B
authors.lastname: Jo
authors.affiliation: Eating Recovery Center, Denver, Colorado.
authors.forename: Craig
authors.initials: C
authors.lastname: Johnson
authors.affiliation: Center for Eating Disorders, Department of Psychiatry, University of California, San Diego.
authors.forename: Walter
authors.initials: W
authors.lastname: Kaye
authors.affiliation: Department of Psychiatry, Washington University, St Louis, Missouri.
authors.forename: Denise
authors.initials: D
authors.lastname: Wilfley
authors.affiliation: Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Blake
authors.initials: B
authors.lastname: Woodside
mesh_terms: D000293:Adolescent; D000856:Anorexia Nervosa / Q000628:therapy*; D001835:Body Weight; D002648:Child; D005196:Family Therapy; D005260:Female; D017048:Health Care Costs; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012074:Remission Induction; D016037:Single-Blind Method; D016896:Treatment Outcome