title: Efficacy and safety of the urolift® system for the treatment of benign prostate hyperplasia symptoms: systematic review.
abstract: BACKGROUND
  Interest in having alternatives in the treatment of benign prostate hyperplasia.
  
  
  OBJECTIVE
  To assess the efficacy and safety of the Urolift® system for treating the symptoms of benign prostate hyperplasia.
  
  
  METHODS
  Systematic review of the literature through searches on PubMed, Cochrane Library, CRD, Clinical Trials and EuroScan, collecting indicators of efficacy and safety.
  We included 5 case series and one clinical trial. The patients' mean age ranged from 65-74.3 years, and the mean prostate volume was 41-55cm3. The mean number of Urolif® implants was 3.7-5.5. The maximum follow-up in months was 24, 12 (3 studies) and one (2 studies). Improvements were found in lower urinary tract symptoms, as measured with the International Prostate Symptom Score, Benign Prostatic Hyperplasia Impact Index (BPHII), maximum urinary flow (Qmax) and postvoid residual (PVR) volume. Improvements were in found sexual dysfunction symptoms, as measured with the Sexual Health Inventory for Men (SHIM) and the Male Sexual Health Questionnaire or Ejaculatory Dysfunction (MHSQ-EjD), and in quality of life (QoL). In the clinical trial, the differences were significant for International Prostate Symptom Score, BPHII, Qmax and QoL (p<.05). The adverse effects were mild.
  
  
  CONCLUSIONS
  Although the quality of evidence is low, Urolift® constitutes a good therapeutic alternative for patients with benign prostate hyperplasia. The short to medium-term results show that the technique contributes to improving lower urinary tract symptoms, with no relevant side effects, does not affect sexual function and improves quality of life. Further research is required, especially on long-term results.
authors.affiliation: Agencia de Evaluación de Tecnologías Sanitarias (AETS), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad, Madrid, España; Instituto de Investigación Sanitaria del Hospital Universitario de La Princesa (IP), Madrid, España; Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC). Electronic address: luism.sanchez@isciii.es.
authors.forename: L M
authors.initials: LM
authors.lastname: Sánchez-Gómez
authors.affiliation: Agencia de Evaluación de Tecnologías Sanitarias (AETS), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Polo-deSantos
authors.affiliation: Instituto de Cirugía Urológica Avanzada, Clínica CEMTRO, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Gómez-Sancha
authors.affiliation: Agencia de Evaluación de Tecnologías Sanitarias (AETS), Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad, Madrid, España.
authors.forename: S
authors.initials: S
authors.lastname: Luengo-Matos
mesh_terms: D000368:Aged; D004106:Dilatation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000209:etiology; D008297:Male; D017060:Patient Satisfaction; D011467:Prostate / Q000601:surgery; D011470:Prostatic Hyperplasia / Q000150:complications / Q000601:surgery*; D019736:Prostheses and Implants; D019919:Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000209:etiology
keywords: Benign prostatic hyperplasia; Cirugía mínimamente invasiva; Hiperplasia benigna prostática; Lift uretral; Minimally invasive surgery; Prostate; Próstata; Revisión sistemática; Systematic review; Urethral lift