title: Bioimaging and subclinical cardiovascular disease in low- and middle-income countries.
abstract: Cardiovascular disease (CVD) is the leading cause of mortality worldwide and also exerts a significant economic burden, especially in low- and middle-income countries (LMICs). Detection of subclinical CVD, before an individual experiences a major event, may therefore offer the potential to prevent or delay morbidity and mortality, if combined with an appropriate care response. In this review, we discuss imaging technologies that can be used to detect subclinical atherosclerotic CVD (carotid ultrasound, coronary artery calcification) and nonatherosclerotic CVD (echocardiography). We review these imaging modalities, including aspects such as rationale, relevance, feasibility, utilization, and access in LMICs. The potential gains in detecting subclinical CVD may be substantial in LMICs, if earlier detection leads to earlier engagement with the health care system to prevent or delay cardiac events, morbidity, and premature mortality. Thus, dedicated studies examining the feasibility, utility, and cost-effectiveness of detecting subclinical CVD in LMICs are warranted.
authors.affiliation: Zena and Michael A. Wiener Cardiovascular Institute, and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY, 10029, USA.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Vedanthan
authors.forename: Brian G
authors.initials: BG
authors.lastname: Choi
authors.forename: Usman
authors.initials: U
authors.lastname: Baber
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuster
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D003906:Developing Countries / Q000191:economics; D003952:Diagnostic Imaging / Q000191:economics / Q000379:methods*; D017048:Health Care Costs; D006297:Health Services Accessibility / Q000191:economics; D006801:Humans; D011203:Poverty; D011237:Predictive Value of Tests; D011379:Prognosis