title: Cell cycle and cell fate in the developing nervous system: the role of CDC25B phosphatase.
abstract: Deciphering the core machinery of the cell cycle and cell division has been primarily the focus of cell biologists, while developmental biologists have identified the signaling pathways and transcriptional programs controlling cell fate choices. As a result, until recently, the interplay between these two fundamental aspects of biology have remained largely unexplored. Increasing data show that the cell cycle and regulators of the core cell cycle machinery are important players in cell fate decisions during neurogenesis. Here, we summarize recent data describing how cell cycle dynamics affect the switch between proliferation and differentiation, with an emphasis on the roles played by the cell cycle regulators, the CDC25 phosphatases.
authors.affiliation: Université Toulouse 3; Centre de Biologie du Développement (CBD), 118 route de Narbonne, 31062, Toulouse, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Agius
authors.forename: Sophie
authors.initials: S
authors.lastname: Bel-Vialar
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bonnet
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pituello
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D009420:Nervous System / Q000166:cytology* / Q000201:enzymology*; D055495:Neurogenesis; D020687:cdc25 Phosphatases / Q000378:metabolism*
chemical_list: D020687:cdc25 Phosphatases