title: Reduction in non syndromic oral clefts following mandatory flour fortification with folic acid in Northern Iran.
abstract: Background Several studies have examined the effects of folic acid fortification on the occurrence of orofacial clefts. This study was carried out to evaluate the impact of flour fortification with folic acid on oral clefts in Northern Iran.
  
  
  METHODS
  In this hospital based study from March 2006 to September 2009, we screened the total number of live births at all hospitals in Golestan province in North of Iran, as well as the number of pregnancies affected by non syndromic oral clefts, per 100000 births during the periods before (March 2006 -June 2007), during (July2007- March 2008) and after (May 2008- September 2009) folic acid fortification of flour was implemented. Non syndromic Oral clefts were defined in accordance with the International Classification of Diseases, 10th revision (ICD-10).
  
  
  RESULTS
  The prevalence of oral clefting reduced from 64.2 per 100000 births before fortification to 32.2 per 100000 after flour fortification with folic acid. The preventive fraction rate of oral clefting after fortification period in comparison with before period was 49.8% (OR=0.502 95% CI 0.26-0.97, p=0.036).
  
  
  CONCLUSIONS
  This study showed that flour fortification with folic acid is associated with a significant reduction in the rate of oral clefting in Golestan province in Northern Iran.
authors.affiliation: 1. PhD, Professor, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran. mjgolalipour@yahoo.com.
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Golalipour
authors.affiliation: 2. PhD, Department of Health and Medical Sciences, Golestan University of Medical Sciences, Gorgan, Iran. mavakili@yahoo.com.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Vakili
authors.affiliation: 3. BSc Researcher, Gorgan Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran. kavianyn@yahoo.com.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Kaviani
keywords: Flour; Folic acid; Fortification; Iran; Oral clefts