title: Growth factor use in medication-induced hematologic toxicity.
abstract: Myelosuppression is a dose-limiting adverse effect with antineoplastic therapy and nonchemotherapy medications. Clinicians have data and guidelines to provide direction for the management of neutropenia and thrombocytopenia in patients with malignancies. Clinical situations outside oncology extrapolate these data along with limited data sets for those patients who demonstrate myelosuppressive effects from medications that are not traditionally considered cytotoxic. Pharmacological treatments can be used to help ameliorate the myelosuppressive toxicities. Recombinant technology has provided growth factors to counteract or lessen the degree of toxicity from myelosuppressive medications including chemotherapy. Clinical strategies and future trends on how to mitigate medication-related myelosuppression are discussed.
authors.affiliation: Department of Pharmacy, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA Duquesne University, Pittsburgh, PA, USA University of Pittsburgh, Pittsburgh, PA, USA rmiller2@wpahs.org.
authors.forename: Rickey C
authors.initials: RC
authors.lastname: Miller
authors.affiliation: Department of Pharmacy, Allegheny General Hospital, Allegheny Health Network, Pittsburgh, PA, USA.
authors.forename: Alison
authors.initials: A
authors.lastname: Steinbach
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007970:Leukopenia / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control; D008533:Megakaryocytes / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy; D009503:Neutropenia / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D065129:Pre-Exposure Prophylaxis; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D036341:Intercellular Signaling Peptides and Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
keywords: drug-induced abnormalities; drug-induced febrile neutropenia; neutropenia; recombinant proteins; thrombocytopenia