title: Identifying significant crosstalk of pathways in tuberous sclerosis complex.
abstract: OBJECTIVE
  Tuberous sclerosis complex (TSC) is the second most common phakomatosis and is characterized by the formation of benign hamartomas and low-grade neoplasms in multiple organ systems. In this study, our objective here was to explore the interaction and crosstalk between pathways in response to tuberous sclerosis complex.
  
  
  METHODS
  We enriched the significant pathways and made the crosstalk analysis of the significant pathways.
  
  
  RESULTS
  The results showed that ECM-receptor interaction was a significant pathway in TSC. In addition, insulin-signaling and mTOR signaling also have been identified involved in TSC here, which have been well characterized. Further analysis indicated that there was a crosstalk between ECM-receptor interaction and antigen processing and presentation, ECM-receptor interaction and apoptosis, and leishmaniasis-oxidative phosphorylation-pancreatic cancer. In this study, a network-based approach was used to analyze the crosstalk among TSC related pathways. The crosstalk of pathways is found and analyzed using the PPI datasets and expression profiles.
  
  
  CONCLUSIONS
  Our work showed that comprehensive and system-wide analysis could provide evidence for TSC pathway and complement the traditional component-based approaches. The crosstalk identified might provide new alternative insights into the TSC pathology, which may contribute to the development of novel therapeutic targets for TSC.
authors.affiliation: Department of Neurology, the First Hospital of Jilin University, Changchun, China. ceiceiliazbl@163.com.
authors.forename: B-L
authors.initials: BL
authors.lastname: Zhang
authors.forename: L-J
authors.initials: LJ
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: H-L
authors.initials: HL
authors.lastname: Zhang
authors.forename: X-M
authors.initials: XM
authors.lastname: Wu
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: F
authors.initials: F
authors.lastname: Deng
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Cheng
authors.forename: J-C
authors.initials: JC
authors.lastname: Feng
mesh_terms: D019295:Computational Biology; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D060066:Protein Interaction Maps; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014402:Tuberous Sclerosis / Q000378:metabolism*; D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D000077004:Tuberous Sclerosis Complex 1 Protein; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases