title: Early neonatal bilirubin, hematocrit, and glucose-6-phosphate dehydrogenase status.
abstract: OBJECTIVE
  To document the patterns of bilirubin and hematocrit values among glucose-6-phosphate dehydrogenase (G6PD)-deficient and G6PD-normal Nigerian neonates in the first week of life, in the absence of exposure to known icterogenic agents.
  
  
  METHODS
  The G6PD status of consecutive term and near-term neonates was determined, and their bilirubin levels and hematocrits were monitored during the first week of life. Infants were stratified into G6PD deficient, intermediate, and normal on the basis of the modified Beutler's fluorescent spot test. Means of total serum bilirubin (TSB) and hematocrits of the 3 groups of infants were compared.
  
  
  RESULTS
  The 644 neonates studied comprised 353 (54.8%) boys and 291 (45.2%) girls and 540 (83.9%) term and 104 (16.1%) near-term infants. They consisted of 129 (20.0%) G6PD-deficient, 69 (10.7%) G6PD-intermediate, and 446 (69.3%) G6PD-normal neonates. The G6PD-deficient and G6PD-intermediate infants had higher mean TSB than their G6PD-normal counterparts at birth and throughout the first week of life (P < .001). Mean peak TSB levels were 14.1 (9.48), 10.2 (3.8), and 6.9 (3.3) mg/dL for G6PD-deficient, G6PD-intermediate, and G6PD-normal neonates, respectively. Peak TSB was attained on approximately day 4 in all 3 groups, and trends in TSB were similar. Mean hematocrits at birth were similar in the 3 G6PD groups. However, G6PD-deficient and -intermediate infants had higher declines in hematocrit, bilirubin levels, and need for phototherapy than G6PD-normal infants (P < .001).
  
  
  CONCLUSIONS
  The G6PD-deficient and G6PD-intermediate neonates had a higher risk of neonatal hyperbilirubinemia and would therefore need greater monitoring in the first week of life, even without exposure to known icterogenic agents.
authors.affiliation: Departments of Paediatrics, bolabadejoko@yahoo.co.uk.
authors.forename: Bolaji O
authors.initials: BO
authors.lastname: Badejoko
authors.affiliation: Departments of Paediatrics, Departments of Paediatrics and Child Health.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Owa
authors.affiliation: Departments of Paediatrics, Departments of Paediatrics and Child Health.
authors.forename: Saheed B A
authors.initials: SB
authors.lastname: Oseni
authors.affiliation: Obstetrics and Gynaecology and Perinatology, and Obstetrics and Gynaecology and Perinatology, and bolabadejoko@yahoo.co.uk.
authors.forename: Olusegun
authors.initials: O
authors.lastname: Badejoko
authors.affiliation: Community Health, Obafemi Awolowo University, Ile-Ife, Nigeria Community Health, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria; and.
authors.forename: Adesegun O
authors.initials: AO
authors.lastname: Fatusi
authors.affiliation: Departments of Paediatrics, Departments of Paediatrics and Child Health.
authors.forename: Ebunoluwa A
authors.initials: EA
authors.lastname: Adejuyigbe
mesh_terms: D000367:Age Factors; D001663:Bilirubin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D006400:Hematocrit / Q000379:methods / Q000639:trends; D006801:Humans; D051556:Hyperbilirubinemia, Neonatal / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D007231:Infant, Newborn; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D005954:Glucosephosphate Dehydrogenase; D001663:Bilirubin
keywords: bilirubin; glucose-6-phosphate dehydrogenase; haematocrit; neonate; nigeria