title: P300 component of event-related potentials in persons with asperger disorder.
abstract: In the present study, we investigated auditory event-related potentials in adults with Asperger disorder and normal controls using an auditory oddball task and a novelty oddball task. Task performance and the latencies of P300 evoked by both target and novel stimuli in the two tasks did not differ between the two groups. Analysis of variance revealed that there was a significant interaction effect between group and electrode site on the mean amplitude of the P300 evoked by novel stimuli, which indicated that there was an altered distribution of the P300 in persons with Asperger disorder. In contrast, there was no significant interaction effect on the mean P300 amplitude elicited by target stimuli. Considering that P300 comprises two main subcomponents, frontal-central-dominant P3a and parietal-dominant P3b, our results suggested that persons with Asperger disorder have enhanced amplitude of P3a, which indicated activated prefrontal function in this task.
authors.affiliation: *Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan; †Department of Language Sciences, Tokyo Metropolitan University, Tokyo, Japan; and ‡Department of Education and Child Studies, Faculty of Arts & Sciences, Sagami Women's University, Kanagawa, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iwanami
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okajima
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Ota
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tani
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamada
authors.forename: Bun
authors.initials: B
authors.lastname: Yamagata
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Chieko
authors.initials: C
authors.lastname: Kanai
authors.forename: Osamu
authors.initials: O
authors.lastname: Takashio
authors.forename: Atsuko
authors.initials: A
authors.lastname: Inamoto
authors.forename: Taisei
authors.initials: T
authors.lastname: Ono
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Takayama
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D020817:Asperger Syndrome / Q000503:physiopathology*; D003657:Decision Making; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D055815:Young Adult