title: Local anesthetic activity of mixtures of cis- and trans-(2-dimethylaminomethylcycloheptyl)-2-alkoxyphenylcarbamates.
abstract: In a previous study, we synthesized two homologous series of racemic stereoisomeric cis- and trans-(2-dimethylaminomethylcycloheptyl)-2-alkoxyphenylcarbamates with alkyl chain lengths ranging from C1 to C8 and analyzed their local anesthetic activity. Here, we show that the local anesthetic activities of mixtures of cis-1 and trans-1 stereoisomers are higher than the sum of activities calculated for the individual stereoisomers at all molar fractions. We conclude that an appropriate ratio of cis- and trans-stereoisomers is necessary to achieve the maximum anesthetic activity of the studied stereoisomeric carbamates.
authors.forename: F
authors.initials: F
authors.lastname: Gregan
authors.forename: J
authors.initials: J
authors.lastname: Gregan
authors.forename: M
authors.initials: M
authors.lastname: Skorsepa
mesh_terms: D000465:Algorithms; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects; D011817:Rabbits; D013237:Stereoisomerism
chemical_list: D000779:Anesthetics, Local; D002219:Carbamates