title: [Familial Mediterranean fever (paroxismal polyserositis, familial recurring polyserositis, periodic disease)].
abstract: Paroxismal polyserositis is an orphan disease most often affecting Mediterranean populations. It is caused by a mutation on chromosome 16 leading to pyrine synthesis disorder. The disease has a characteristic clinical picture, the most prominent manifestation being recurrent aseptic inflammation of serous membranes especially in peritoneum, marked temperature reaction, and apparent spontaneous recovery in the attack-free period. Inadequate or excessively intense treatment may cause complication in the form of secondary amyloidosis of internal organs. The most effective therapeutic modality is daily intake of colchicine at a dose of 1-1.5 mg.
authors.forename: I A
authors.initials: IA
authors.lastname: Shamov
mesh_terms: D010505:Familial Mediterranean Fever / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D006801:Humans