title: Vascular Dysfunction in Diabetes and Glaucoma: A Complex Relationship Reviewed.
abstract: Open-angle glaucoma (OAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. Intraocular pressure, ocular perfusion pressure, and systemic vascular irregularities have all been identified as contributing factors for glaucoma onset and progression. Focal and systemic vascular abnormalities have also been well documented in diabetic patients. The relationship between diabetes mellitus and OAG remains enigmatic in the literature. As the pathogenesis of both diabetes mellitus and OAG involves compromised vascular regulation, this review was undertaken to further investigate their precise relationship. A literature review of published population-based studies was performed, with a focus on studies regarding blood flow abnormalities. Although current studies support the role of vascular contributions to both diseases, the association between glaucoma and diabetes yields contrasting results.
authors.affiliation: Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Austin L
authors.initials: AL
authors.lastname: Gerber
authors.forename: Alon
authors.initials: A
authors.lastname: Harris
authors.forename: Brent
authors.initials: B
authors.lastname: Siesky
authors.forename: Eric
authors.initials: E
authors.lastname: Lee
authors.forename: Tara J
authors.initials: TJ
authors.lastname: Schaab
authors.forename: Andrew
authors.initials: A
authors.lastname: Huck
authors.forename: Annahita
authors.initials: A
authors.lastname: Amireskandari
mesh_terms: D001783:Blood Flow Velocity; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000473:pathology; D012171:Retinal Vessels / Q000502:physiology; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis; D014794:Visual Fields / Q000502:physiology