title: T cell immune abnormalities in immune thrombocytopenia.
abstract: Immune thrombocytopenia is an autoimmune disease with abnormal T cell immunity. Cytotoxic T cells, abnormal T regulatory cells, helper T cell imbalance, megakaryocyte maturation abnormalities and abnormal T cell anergy are involved in the pathogenesis of this condition. The loss of T cell-mediated immune tolerance to platelet auto-antigens plays a crucial role in immune thrombocytopenia. The induction of T cell tolerance is an important mechanism by which the pathogenesis and treatment of immune thrombocytopenia can be studied. Studies regarding the roles of the new inducible costimulator signal transduction pathway, the ubiquitin proteasome pathway, and the nuclear factor kappa B signal transduction pathway in the induction of T cell tolerance can help improve our understanding of immune theory and may provide a new theoretical basis for studying the pathogenesis and treatment of immune thrombocytopenia.
authors.affiliation: Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Rd, Jinan, Shandong, 250012, People's Republic of China. jmm7751@163.com.
authors.forename: Xuebin
authors.initials: X
authors.lastname: Ji
authors.affiliation: Jinan Stomatological Hospital, Jinan, People's Republic of China. kitty_922@163.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Rd, Jinan, Shandong, 250012, People's Republic of China. junpeng88@sina.com.cn.
authors.forename: Jun
authors.initials: J
authors.lastname: Peng
authors.affiliation: Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Rd, Jinan, Shandong, 250012, People's Republic of China. houming@medmail.com.cn.
authors.forename: Ming
authors.initials: M
authors.lastname: Hou
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology; D013921:Thrombocytopenia / Q000276:immunology* / Q000473:pathology