title: Propylthiouracil-Induced Vasculitis With Antineutrophil Cytoplasmic Antibody.
abstract: Propylthiouracil (PTU)-associated vasculitis is a potentially life-threatening disease with a recent increase in the reported cases in the medical literature. This increase may suggest that some earlier cases have been unrecognized or assigned to an alternative nosology category. Although the skin can be the only organ affected by PTU-associated vasculitis, there are many reports with multiple-system involvement. Classically, the symptoms appear under a tetrad of fever, sore throat, arthralgia, and skin lesions. Cutaneous lesions in reported cases of PTU vasculitis have most commonly consisted of retiform acral, purpuric plaques, or nodules. We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Grave's disease.
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Paulo Ricardo
authors.initials: PR
authors.lastname: Criado
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Ana Claudia
authors.initials: AC
authors.lastname: Grizzo Peres Martins
authors.affiliation: University of São Paulo, São Paulo, Brazil.
authors.forename: Camila Fatima
authors.initials: CF
authors.lastname: Gaviolli
authors.affiliation: University of Toronto, Toronto, Ontario, Canada afsaneh.alavi@utoronto.ca.
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Alavi
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology*; D013956:Antithyroid Agents / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D005260:Female; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D011441:Propylthiouracil / Q000009:adverse effects* / Q000627:therapeutic use; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D013956:Antithyroid Agents; D011441:Propylthiouracil
keywords: ANCA; hyperthyroidism; propylthiouracil; vasculitis