title: Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy.
abstract: Maternal diabetes induces a pro-oxidant/pro-inflammatory intrauterine environment related to the induction of congenital anomalies. Peroxisome proliferator activated receptors (PPARs) are transcription factors that regulate antioxidant and anti-inflammatory pathways. We investigated whether maternal diets supplemented with olive oil, enriched in oleic acid, a PPAR agonist, can regulate the expression of PPAR system genes, levels of lipoperoxidation and activity of matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in embryos and decidua from diabetic rats. The embryos and decidua from diabetic rats showed reduced expression of PPARs and increased concentration of lipoperoxidation, MMPs and TIMPs, whereas the maternal treatments enriched in olive oil increased PPARδ in embryos and PPARγ and PPARγ-coactivator-1α expression in decidua, and increased TIMPs concentrations and decreased lipoperoxidation and MMPs activity in both tissues. Thus, maternal diets enriched in olive oil can regulate embryonic and decidual PPAR system genes expression and reduce the pro-oxidant/pro-inflammatory environment during rat early organogenesis.
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina. Electronic address: rominahiga@gmail.com.
authors.forename: Romina
authors.initials: R
authors.lastname: Higa
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina. Electronic address: sabrina.roberti@live.com.ar.
authors.forename: Sabrina Lorena
authors.initials: SL
authors.lastname: Roberti
authors.affiliation: Department of Biological Chemistry, School of Natural Sciences, University of Buenos Aires, Intendente Guiraldes 2160, C1428EGA Buenos Aires, Argentina. Electronic address: musi90@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Musikant
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina. Electronic address: m.bmazzucco@yahoo.com.ar.
authors.forename: María Belén
authors.initials: MB
authors.lastname: Mazzucco
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina. Electronic address: vernica73@gmail.com.
authors.forename: Verónica
authors.initials: V
authors.lastname: White
authors.affiliation: Laboratory of Reproduction and Metabolism, CEFYBO-CONICET, School of Medicine, University of Buenos Aires, Paraguay 2155, 17th floor, 1121ABG Buenos Aires, Argentina. Electronic address: a.jawerbaum@gmail.com.
authors.forename: Alicia
authors.initials: A
authors.lastname: Jawerbaum
mesh_terms: D000818:Animals; D003656:Decidua / Q000187:drug effects; D019587:Dietary Supplements; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000517:prevention & control*; D005333:Fetus / Q000187:drug effects; D020782:Matrix Metalloproteinases / Q000187:drug effects; D000069463:Olive Oil / Q000008:administration & dosage / Q000009:adverse effects*; D018384:Oxidative Stress / Q000187:drug effects; D047492:Peroxisome Proliferator-Activated Receptors / Q000187:drug effects; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000069463:Olive Oil; D047492:Peroxisome Proliferator-Activated Receptors; D020782:Matrix Metalloproteinases
keywords: Diabetes; Matrix metalloproteinases; Olive oil; PPAR; Pregnancy; Reactive oxygen species