title: Enhanced cell growth on nanotextured GaN surface treated by UV illumination and fibronectin adsorption.
abstract: Semiconductors are important materials used for the development of high-performance biomedical devices. Gallium nitride (GaN) is a well-known III-nitride semiconductor with excellent optoelectronic properties as well as high chemical stability and biocompatibility. The formation of tight interfaces between GaN substrates and cells would be crucial for GaN-based devices used for probing and manipulating biological processes of cells. Here we report a strategy to greatly enhance cell adhesion and survival on nanotextured GaN surface which was treated by UV illumination and fibronectin (FN) adsorption. Cell studies showed that the UV/FN treatment greatly enhanced cell adhesion and growth on nanotextured GaN surfaces. These observations suggest new opportunities for novel nanotextured GaN-based biomedical devices.
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Jingying
authors.initials: J
authors.lastname: Li
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China.
authors.forename: Qiusen
authors.initials: Q
authors.lastname: Han
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China; Department of Chemistry, Yangzhou University, Yangzhou 225009, China.
authors.forename: Xinhuan
authors.initials: X
authors.lastname: Wang
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: yangr@nanoctr.cn.
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.affiliation: CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: wangch@nanoctr.cn.
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D005353:Fibronectins / Q000737:chemistry*; D005708:Gallium / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D049329:Nanostructures / Q000737:chemistry; D012666:Semiconductors; D014466:Ultraviolet Rays
chemical_list: D005353:Fibronectins; C473348:gallium nitride; D005708:Gallium
keywords: Cell adhesion; Fibronectin adsorption; Gallium nitride; Nano/biointerface; Semiconductor