title: Sesquiterpenoids and lignans from the roots of Syringa pinnatifolia.
abstract: Two new sesquiterpenoids, pinnatifone A (1) and pinnatifone B (2), and two new lignans, pinnatifolin (3) and isopinnatifolin (4), along with six known lignans (5-10), were isolated from the roots of Syringa pinnatifolia. The structures of the new compounds were elucidated by extensive spectroscopic methods, including NMR, MS, UV, and IR spectra. The lignans were screened for their anti-oxidant activity (2,2-diphenyl-1-picrylhydrazyl (DPPH) assay). Most of them showed potent anti-oxidant activity, especially compound 5, whose potent anti-oxidant activity had an SC50 value higher than that of the positive control vitamin C.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University.
authors.forename: Ze-Ming
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Zeng
authors.forename: Qiu
authors.initials: Q
authors.lastname: Qiu
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Li
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
mesh_terms: D018360:Crystallography, X-Ray; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D053147:Plant Exudates / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification; D031662:Syringa / Q000737:chemistry* / Q000378:metabolism
chemical_list: D017705:Lignans; D053147:Plant Exudates; D012717:Sesquiterpenes