title: HIV-2 X4 tropism is associated with lower CD4+ cell count in treatment-experienced patients.
abstract: The distribution and evolution of X4/R5 viral tropism during HIV-2 infection remains unknown. HIV-2 tropism was assessed in 83 antiretroviral-experienced patients with virological failure. Tropism was predicted as X4 in 58% of patients and was associated with a CD4 cell count of less than 100 cells/μl, and with a higher number of drug resistance mutations. This high prevalence of X4 virus might compromise the use of CCR5 inhibitors, currently mostly considered in HIV-2 salvage therapy of highly pretreated patients.
authors.affiliation: aINSERM, IAME, UMR 1137 bUniversité Paris Diderot, IAME, UMR 1137, Sorbonne Paris Cité cAP-HP, Hôpital Bichat, Laboratoire de Virologie, Paris dUniversité Bordeaux eINSERM, ISPED, Centre INSERM U897- Epidemiologie-Biostatistique, Bordeaux fAP-HP, Hôpital Bichat, Service de Maladies Infectieuses et Tropicales gAP-HP, Hôpital de la Pitié-Salpétrière, Service de Maladies Infectieuses et Tropicales, Paris, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Visseaux
authors.forename: Charlotte
authors.initials: C
authors.lastname: Charpentier
authors.forename: Caroline
authors.initials: C
authors.lastname: Rouard
authors.forename: Catherine
authors.initials: C
authors.lastname: Fagard
authors.forename: David
authors.initials: D
authors.lastname: Glohi
authors.forename: Roland
authors.initials: R
authors.lastname: Tubiana
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
mesh_terms: D065100:CCR5 Receptor Antagonists / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D003510:Cyclohexanes / Q000627:therapeutic use*; D018450:Disease Progression; D024882:Drug Resistance, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D015498:HIV-2 / Q000502:physiology; D006801:Humans; D000077592:Maraviroc; D015995:Prevalence; D019713:Receptors, CCR5 / Q000187:drug effects*; D012189:Retrospective Studies; D014230:Triazoles / Q000627:therapeutic use*; D019562:Viral Load; D056189:Viral Tropism
chemical_list: D065100:CCR5 Receptor Antagonists; C584933:CCR5 protein, human; D003510:Cyclohexanes; D019713:Receptors, CCR5; D014230:Triazoles; D000077592:Maraviroc