title: Genetic association of impulsivity in young adults: a multivariate study.
abstract: Impulsivity is a heritable, multifaceted construct with clinically relevant links to multiple psychopathologies. We assessed impulsivity in young adult (N~2100) participants in a longitudinal study, using self-report questionnaires and computer-based behavioral tasks. Analysis was restricted to the subset (N=426) who underwent genotyping. Multivariate association between impulsivity measures and single-nucleotide polymorphism data was implemented using parallel independent component analysis (Para-ICA). Pathways associated with multiple genes in components that correlated significantly with impulsivity phenotypes were then identified using a pathway enrichment analysis. Para-ICA revealed two significantly correlated genotype-phenotype component pairs. One impulsivity component included the reward responsiveness subscale and behavioral inhibition scale of the Behavioral-Inhibition System/Behavioral-Activation System scale, and the second impulsivity component included the non-planning subscale of the Barratt Impulsiveness Scale and the Experiential Discounting Task. Pathway analysis identified processes related to neurogenesis, nervous system signal generation/amplification, neurotransmission and immune response. We identified various genes and gene regulatory pathways associated with empirically derived impulsivity components. Our study suggests that gene networks implicated previously in brain development, neurotransmission and immune response are related to impulsive tendencies and behaviors.
authors.affiliation: Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA.
authors.forename: S
authors.initials: S
authors.lastname: Khadka
authors.affiliation: Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA.
authors.forename: B
authors.initials: B
authors.lastname: Narayanan
authors.affiliation: Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Meda
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gelernter
authors.affiliation: 1] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA [2] Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Han
authors.affiliation: Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA.
authors.forename: B
authors.initials: B
authors.lastname: Sawyer
authors.affiliation: Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA.
authors.forename: F
authors.initials: F
authors.lastname: Aslanzadeh
authors.affiliation: 1] Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Stevens
authors.affiliation: 1] Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Hawkins
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: A
authors.initials: A
authors.lastname: Anticevic
authors.affiliation: 1] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA [2] Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Potenza
authors.affiliation: 1] Olin Neuropsychiatry Research Center/Institute of Living, Hartford Healthcare, Hartford, CT, USA [2] Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA [3] Department of Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Pearlson
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D057566:Self Report; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis; D055815:Young Adult