title: Patient-centred pharmaceutical design to improve acceptability of medicines: similarities and differences in paediatric and geriatric populations.
abstract: Patient acceptability of a medicinal product is a key aspect in the development and prescribing of medicines. Children and older adults differ in many aspects from the other age subsets of population and require particular considerations in medication acceptability. This review highlights the similarities and differences in these two age groups in relation to factors affecting acceptability of medicines. New and conventional formulations of medicines are considered regarding their appropriateness for use in children and older people. Aspects of a formulation that impact acceptability in these patient groups are discussed, including, for example, taste/smell/viscosity of a liquid and size/shape of a tablet. A better understanding of the acceptability of existing formulations highlights opportunities for the development of new and more acceptable medicines and facilitates safe and effective prescribing for the young and older populations.
authors.affiliation: Department of Pharmacy, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, AL10 9AB, UK. f.liu3@herts.ac.uk.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Sejal
authors.initials: S
authors.lastname: Ranmal
authors.affiliation: Pharmacy, Pharmacology and Therapeutics, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
authors.forename: Hannah K
authors.initials: HK
authors.lastname: Batchelor
authors.affiliation: Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Mine
authors.initials: M
authors.lastname: Orlu-Gul
authors.affiliation: GlaxoSmithKline, Harlow, Essex, CM19 5AW, UK.
authors.forename: Terry B
authors.initials: TB
authors.lastname: Ernest
authors.affiliation: Piramal Healthcare UK Ltd, Morpeth, Northumberland, NE61 3YA, UK.
authors.forename: Iwan W
authors.initials: IW
authors.lastname: Thomas
authors.affiliation: Pharmaceutical Development, AstraZeneca, Macclesfield, Cheshire, SK10 2NA, UK.
authors.forename: Talia
authors.initials: T
authors.lastname: Flanagan
authors.affiliation: Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, UK.
authors.forename: Catherine
authors.initials: C
authors.lastname: Tuleu
mesh_terms: D000367:Age Factors; D000368:Aged; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002648:Child; D015195:Drug Design; D006801:Humans; D010349:Patient Compliance / Q000523:psychology / Q000706:statistics & numerical data*; D018802:Patient-Centered Care / Q000379:methods*; D013607:Tablets
chemical_list: D013607:Tablets