title: Fungaemia caused by Fusarium proliferatum in a patient without definite immunodeficiency.
abstract: Recent literature has shown the growing importance of opportunistic fungal infections due to Fusarium spp. However, disseminated fusariosis remains rare in patients without neutropenia. We report a case of fungaemia in a 78-year-old French woman without definite immunodeficiency. Fusarium proliferatum grew from both central and peripheral blood cultures. Fever was the only clinical sign of the infection. An appropriate antifungal therapy with voriconazole led to the recovery of the patient. An environmental investigation was undertaken but failed to find a reservoir of Fusarium spores. A contaminated central venous catheter might have been the source of fungaemia.
authors.affiliation: Infection Control Department and Environmental Analysis Laboratory, Service Hygiène, Epidémiologie et Prévention, Groupement Hospitalier Edouard Herriot, Hospices Civils de Lyon, 5 place d'Arsonval, 69437, Lyon Cedex 03, France, cedric.dananche@chu-lyon.fr.
authors.forename: Cédric
authors.initials: C
authors.lastname: Dananché
authors.forename: Pierre
authors.initials: P
authors.lastname: Cassier
authors.forename: Marc
authors.initials: M
authors.lastname: Sautour
authors.forename: Nadine
authors.initials: N
authors.lastname: Gautheron
authors.forename: Julien
authors.initials: J
authors.lastname: Wegrzyn
authors.forename: Michel
authors.initials: M
authors.lastname: Perraud
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Bienvenu
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Nicolle
authors.forename: André
authors.initials: A
authors.lastname: Boibieux
authors.forename: Philippe
authors.initials: P
authors.lastname: Vanhems
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects; D055499:Catheter-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D062905:Central Venous Catheters / Q000382:microbiology; D005260:Female; D005602:France; D060585:Fusariosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D005670:Fusarium / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009894:Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D065819:Voriconazole