title: Steatotic hepatocellular adenomas with different phenotypic subtypes: a case report.
abstract: Hepatocellular adenomas (HCAs) are heterogeneous group of benign tumors; three pathomolecular subtypes have been identified so far: hepatocyte nuclear factor 1 α-inactivated HCA (H-HCA) (35-40%), inflammatory HCA (I-HCA) (>50%), β-catenin activated HCA (10%). Ten percent of I-HCA are also β-catenin activated. We report a rare case of three histologically confirmed steatotic HCAs of three different phenotypes: I-HCA, β-catenin activated I-HCA, and H-HCA in a 36-year-old woman. This observation outlines that in the same patient, HCA may be of different subtypes. The predisposition to develop different HCA hypothetically caused by a "benign tumorigenic field effect" may result, even rarely, in different genotypes/phenotypes such as H-HCA and I-HCA. Moreover, we illustrate the very high specificity of MR for subtyping HCA.
authors.affiliation: Department of Radiology, hôpital St-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France. Electronic address: nicoalbertibdx@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Alberti
authors.affiliation: Department of Pathology, hôpital Pellegrin, CHU de Bordeaux, place Amélie-Raba-Léon, 33000 Bordeaux, France.
authors.forename: C
authors.initials: C
authors.lastname: Castain
authors.affiliation: Department of Radiology, hôpital St-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
authors.forename: A
authors.initials: A
authors.lastname: Crombe
authors.affiliation: Department of Radiology, hôpital St-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33000 Bordeaux, France.
authors.forename: N
authors.initials: N
authors.lastname: Frulio
mesh_terms: D018248:Adenoma, Liver Cell / Q000150:complications / Q000235:genetics*; D000328:Adult; D005234:Fatty Liver / Q000150:complications; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000235:genetics*