title: [A rare case of hypoglycemia in an elderly patient with type 2 diabetes mellitus: malignant metastasizing insulinoma].
abstract: The incidence of insulinoma, an insulin-producing tumour arising from pancreatic beta-cells and responsible for the development of fasting hypoglycemia, in the general population is 1-4 per 1,000,000 yearly, mostly at the age of 25-55 yr. Malignization of this neoplasm occurs in 10-15% of the cases. One third of the tumours produce metastases. The most characteristic clinical manifestation of insulinoma is the Whipple's triad, with episodes of fasting hypoglycemia (below 2.8 mmol/l) correctable by intravenous glucose injection or intake of sugar. The authors report a case of intravital diagnosis of malignant metastasizing insulinoma in a 82 year old woman with type 2 diabetes mellitus. A review of relevant literature is presented.
authors.forename: V I
authors.initials: VI
authors.lastname: Podzolkov
authors.forename: N A
authors.initials: NA
authors.lastname: Dragomiretskaia
authors.forename: T V
authors.initials: TV
authors.lastname: Koroleva
authors.forename: N N
authors.initials: NN
authors.lastname: Kavtaradze
authors.forename: H H
authors.initials: HH
authors.lastname: Iakovleva
authors.forename: A V
authors.initials: AV
authors.lastname: Podzolkov
mesh_terms: D000369:Aged, 80 and over; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D007340:Insulinoma / Q000453:epidemiology / Q000473:pathology* / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000150:complications / Q000453:epidemiology / Q000473:pathology*