title: Risk for CMV reactivation in children undergoing allogeneic hematopoietic stem cell transplantation.
abstract: Tailoring pre-emptive CMV therapy to hematopoietic cell transplant recipients' risk for reactivation could make this approach more cost-effective. To determine the feasibility of creating a risk classification system for this purpose, we analyzed 169 pediatric HCTs involving seropositive recipients or donors. Using risk factors derived from multivariable analysis, we stratified patients as having no risk factors, any one, any two, or all three risk factors (age, donor type, and presence of GVHD). The cumulative incidence of reactivation was 4.7%, 10.1%, 21.1%, and 40.9%, respectively (P ≤ 0.001). These results demonstrate the feasibility of creating a risk classification schema. Pediatr Blood Cancer 2015;62:364-366. © 2014 Wiley Periodicals, Inc.
authors.affiliation: Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Muna
authors.initials: M
authors.lastname: Qayed
authors.affiliation: Hematology-Oncology, Children's Hospital and Research Center Oakland, Oakland, California.
authors.forename: Monica
authors.initials: M
authors.lastname: Khurana
authors.affiliation: Pediatric Infectious Diseases, Emory University, Atlanta, Georgia.
authors.forename: Joseph
authors.initials: J
authors.lastname: Hilinski
authors.affiliation: Pediatric Infectious Diseases, Emory University, Atlanta, Georgia.
authors.forename: Scott
authors.initials: S
authors.lastname: Gillespie
authors.affiliation: Pediatric Infectious Diseases, Emory University, Atlanta, Georgia.
authors.forename: Courtney
authors.initials: C
authors.lastname: McCracken
authors.affiliation: Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Kristy
authors.initials: K
authors.lastname: Applegate
authors.affiliation: Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
authors.forename: Kuang-Yueh
authors.initials: KY
authors.lastname: Chiang
authors.affiliation: Morgan Stanley Children's Hospital of New York, Columbia University, New York, New York.
authors.forename: John
authors.initials: J
authors.lastname: Horan
mesh_terms: D000293:Adolescent; D003587:Cytomegalovirus / Q000187:drug effects / Q000254:growth & development*; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012307:Risk Factors; D014775:Virus Activation / Q000502:physiology*
keywords: CMV; surveillance; transplantation