title: Case report: first report of a prosthetic joint infection caused by Facklamia hominis.
abstract: Facklamia spp. are gram-positive cocci first described in 1997. They are α-hemolytic, facultative anaerobes, catalase-negative cocci, resembling viridians streptococci on 5% sheep blood agar. Facklamia hominis is, by far, the most common species of the 6 so far described, and it is thought that its natural habitat is the female genital tract. Four previous human infections with Facklamia spp. have been documented. We report the first case of a chronic prosthetic joint infection caused by F. hominis and its successful treatment by a 2-stage exchange procedure to eradicate the infection. This is also the first osteoarticular infection reported. The clinical implications are discussed.
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain; Reconstructive Surgery and Septic Division, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain. Electronic address: pcorona@vhebron.net.
authors.forename: Pablo S
authors.initials: PS
authors.lastname: Corona
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: Sleiman
authors.initials: S
authors.lastname: Haddad
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Andrés
authors.affiliation: Microbiology Department, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain; Universitat Autònoma de Barcelona, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: Juan José
authors.initials: JJ
authors.lastname: González-López
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain; Reconstructive Surgery and Septic Division, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: Carles
authors.initials: C
authors.lastname: Amat
authors.affiliation: Department of Orthopaedic Surgery, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain; Reconstructive Surgery and Septic Division, Hospital Universitario Vall d'Hebron, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Flores
mesh_terms: D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019643:Arthroplasty, Replacement; D019644:Arthroplasty, Replacement, Hip; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006095:Gram-Positive Cocci / Q000187:drug effects / Q000472:pathogenicity*; D006801:Humans; D007595:Joint Prosthesis / Q000009:adverse effects*; D016459:Prosthesis-Related Infections / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D000658:Amoxicillin; D013752:Tetracycline
keywords: Antibiotic resistance; Facklamia hominis; Periprosthetic joint infection; Two-stage replacement