title: The mean platelet volume is significantly associated with higher glycated hemoglobin in a large population of unselected outpatients.
abstract: OBJECTIVE
  To examine the association between mean platelet volume (MPV) and glycated hemoglobin (HbA1c) in a large cohort of unselected outpatients.
  
  
  METHODS
  We retrospectively reviewed combined results of complete blood count (CBC) and hemoglobin A1c (HbA1c) performed in all outpatients aged 18 years or older, who were referred to the outpatient clinic of our hospital for routine health check-up during the year 2013.
  
  
  RESULTS
  Cumulative results of both CBC and HbA1c could be retrieved for 4072 male and female outpatients aged 18 years or older. There were significant associations between HbA1c and both MPV (r=0.10; p<0.001) and platelet count (r=0.05; p<0.001), that remained statistically significant after adjusting for age and sex. After stratifying the whole sample of patients for MPV quartiles, there was a significant, positive trend of HbA1c across quartiles of MPV (p<0.001). Similar findings were found when the whole sample was stratified by clinical thresholds of HbA1c (p<0.001), with values of MPV gradually increasing from subjects with normal glucose homeostasis, pre-diabetes and diabetes.
  
  
  CONCLUSIONS
  The results of our investigation, which is supposed to be the largest cohort study on unselected outpatients assessing the relationship between HbA1c and platelets number or size, indicate that elevated MPV is significantly associated with higher HbA1c levels and vice versa.
authors.affiliation: Laboratory of Clinical Chemistry and Hematology, Academic Hospital of Parma, Parma, Italy. Electronic address: glippi@ao.pr.it.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.affiliation: Laboratory of Clinical Chemistry and Hematology, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Salvagno
authors.affiliation: Department of Clinical and Experimental Medicine, Academic Hospital of Parma, Parma, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Nouvenne
authors.affiliation: Department of Clinical and Experimental Medicine, Academic Hospital of Parma, Parma, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Meschi
authors.affiliation: Department of Clinical and Experimental Medicine, Academic Hospital of Parma, Parma, Italy.
authors.forename: Loris
authors.initials: L
authors.lastname: Borghi
authors.affiliation: Section of Endocrinology, Diabetes and Metabolism, University of Verona and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007558:Italy; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010045:Outpatients; D010976:Platelet Count; D011236:Prediabetic State / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Diabetes; Glycated hemoglobin; MPV; Mean platelet volume; Platelets