title: Assessing two methods of repair of duodenal defects, jejunal serosal patch and jejunal pedicled flap, (an experimental animal study).
abstract: OBJECTIVE
  To evaluate the outcomes of jejunal serosal patch and jejunal pedicled flap procedures for the repair of duodenal injuries.
  
  
  METHODS
  The experimental animal-model study was conducted at Shiraz University of Medical Sciences, Iran, in February 2013. Ten mixed-breed male dogs were selected and randomly divided into groups A and B. After general anaesthesia, a large duodenal defect was created in all animals. The defect was repaired with jejunal pedicled flap in group A and jejunal serosal patch in group B. Microscopic healing was scored according to epithelialisation, collagenisation, inflammation, ulcer and necrosis of samples. Kolmogorov-Smirnov and independent t-test were used to indicate normal distributions of data and statistical differences between the two groups respectively.
  
  
  RESULTS
  The weight of the animals ranged between 23 and 37 kg and the age range was 12-16 months. All dogs survived the procedures. Anastomotic leakage, intra-abdominal abscess or intestinal obstructions were not detected in gross examination. Healing score was significantly higher in the group A than group B (p < 0.011). However, in terms of surgical findings, no significant difference was detected between the groups (p > 0.05).
  
  
  CONCLUSIONS
  Applying jejunal pedicled flap for repairing large duodenal defects would lead to better histologic outcomes compared to jejunal serosal patch in dogs.
authors.forename: Bizhan
authors.initials: B
authors.lastname: Ziaian
authors.forename: Massood
authors.initials: M
authors.lastname: Hosseinzadeh
authors.forename: Behroz
authors.initials: B
authors.lastname: Nikravesh
authors.forename: Reza
authors.initials: R
authors.lastname: Roshanravan
authors.forename: Salar
authors.initials: S
authors.lastname: Rahimikazerooni
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Safarpour
authors.forename: Sam
authors.initials: S
authors.lastname: Moslemi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004386:Duodenum / Q000293:injuries*; D007492:Iran; D007583:Jejunum / Q000637:transplantation*; D008297:Male; D011183:Postoperative Complications; D011897:Random Allocation; D013524:Surgical Flaps; D014945:Wound Healing