title: [Metastatic breast cancer with microangiopathic hemolytic anemia successfully treated by using eribulin].
abstract: A 48-year-old woman was diagnosed with metastatic breast carcinoma and multiple bone metastases as well as a brain metastasis in 2004. Multiple bone metastases and brain metastases were also diagnosed in 2005, 2006, and 2010, but she remained stable with the use of chemotherapy and hormonal therapy for about 8 years. In 2013, severe anemia occurred, and the patient was diagnosed with microangiopathic hemolytic anemia (MHA). She was treated with eribulin(1.4 mg/m²), and recovered successfully after treatment. Approximately 8 months have elapsed after initiating the therapy, and there has been no recurrence. MHA associated with breast cancer is very rare, and is regarded as a disease with a poor prognosis. However, eribulin could be a valid treatment for prolonging the survival of patients with MHA associated with breast cancer.
authors.affiliation: Dept. of Surgery, Saiseikai Shiga Hospital.
authors.forename: Midori
authors.initials: M
authors.lastname: Morita
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Fukuda
authors.forename: Tomoki
authors.initials: T
authors.lastname: Konishi
authors.forename: Jun
authors.initials: J
authors.lastname: Kiuchi
authors.forename: Seiji
authors.initials: S
authors.lastname: Umehara
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakashima
authors.forename: Junshin
authors.initials: J
authors.lastname: Fujiyama
authors.forename: Mamoru
authors.initials: M
authors.lastname: Masuyama
mesh_terms: D000743:Anemia, Hemolytic / Q000188:drug therapy*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001932:Brain Neoplasms / Q000188:drug therapy / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005663:Furans / Q000627:therapeutic use*; D006801:Humans; D007659:Ketones / Q000627:therapeutic use*; D008875:Middle Aged; D011788:Quality of Life; D000095662:Polyether Polyketides
chemical_list: D005663:Furans; D007659:Ketones; C490954:eribulin; D000095662:Polyether Polyketides