title: Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression.
abstract: We found that resveratrol enhances interferon (IFN)-γ-induced tryptophanyl-tRNA-synthetase (TTS) expression in bone marrow- derived dendritic cells (BMDCs). Resveratrol-induced TTS expression is associated with glycogen synthase kinase-3β (GSK-3β) activity. In addition, we found that resveratrol regulates naïve CD8+ T-cell polarization by modulating GSK-3β activity in IFN-γ-stimulated BMDCs, and that resveratol induces upregulation of TTS in CD8+ T-cells in the in vivo tumor environment. Taken together, resveratrol upregulates IFN-γ-induced TTS expression in a GSK-3β-dependent manner, and this TTS modulation is crucial for DC-mediated T-cell modulation.
authors.affiliation: Department of Infectious Diseases, Armed Forces Medical Research Institute, Daejeon 305-878, Korea.
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Noh
authors.affiliation: Department of Neurosurgery, College of Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Joon
authors.initials: J
authors.lastname: Cho
authors.affiliation: Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Chun
authors.affiliation: Department of Dental Hygiene, Hanseo University, Seosan 356-706, Korea.
authors.forename: Jong-Hwa
authors.initials: JH
authors.lastname: Jang
authors.affiliation: Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
authors.forename: Gil Sun
authors.initials: GS
authors.lastname: Cha
authors.affiliation: Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
authors.forename: In Duk
authors.initials: ID
authors.lastname: Jung
authors.affiliation: Department of Infectious Diseases, Armed Forces Medical Research Institute, Daejeon 305-878, Korea.
authors.forename: Dong Deuk
authors.initials: DD
authors.lastname: Jang
authors.affiliation: Department of Immunology, Lab of Dendritic Cell Differentiation & Regulation, KU Open Innovation Center and School of Medicine, Konkuk University, Chungju 380-701, Korea.
authors.forename: Yeong-Min
authors.initials: YM
authors.lastname: Park
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014369:Tryptophan-tRNA Ligase / Q000378:metabolism*; D015854:Up-Regulation / Q000187:drug effects*
chemical_list: D013267:Stilbenes; D007371:Interferon-gamma; D014369:Tryptophan-tRNA Ligase; D000077185:Resveratrol