title: Cortical source multivariate EEG synchronization analysis on amnestic mild cognitive impairment in type 2 diabetes.
abstract: Is synchronization altered in amnestic mild cognitive impairment (aMCI) and normal cognitive functions subjects in type 2 diabetes mellitus (T2DM)? Resting eye-closed EEG data were recorded in 8 aMCI subjects and 11 age-matched controls in T2DM. Three multivariate synchronization algorithms (S-estimator (S), synchronization index (SI), and global synchronization index (GSI)) were used to measure the synchronization in five ROIs of sLORETA sources for seven bands. Results showed that aMCI group had lower synchronization values than control groups in parietal delta and beta2 bands, temporal delta and beta2 bands, and occipital theta and beta2 bands significantly. Temporal (r = 0.629; P = 0.004) and occipital (r = 0.648; P = 0.003) theta S values were significantly positive correlated with Boston Name Testing. In sum, each of methods reflected that the cortical source synchronization was significantly different between aMCI and control group, and these difference correlated with cognitive functions.
authors.affiliation: School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China.
authors.forename: Dong
authors.identifier: 0000-0002-6468-1197
authors.initials: D
authors.lastname: Cui
authors.affiliation: School of Information Science and Engineering, Yanshan University, Qinhuangdao 066004, China.
authors.forename: Jing
authors.identifier: 0000-0001-9549-0177
authors.initials: J
authors.lastname: Liu
authors.affiliation: School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Bian
authors.affiliation: Department of Neurology, General Hospital of Second Artillery Corps of PLA, Beijing 100875, China.
authors.forename: Qiuli
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Neurology, General Hospital of Second Artillery Corps of PLA, Beijing 100875, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China ; State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China ; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing 100875, China ; National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Li
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001611:Beta Rhythm; D002540:Cerebral Cortex / Q000503:physiopathology*; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D003344:Cortical Synchronization; D003700:Delta Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D015999:Multivariate Analysis; D013826:Theta Rhythm