title: One-step preparation of a water-soluble carbon nanohorn/phthalocyanine hybrid for dual-modality photothermal and photodynamic therapy.
abstract: The biomedical applications of carbon nanomaterials, especially integrating noninvasive photothermal therapy (PTT) and photodynamic therapy (PDT), into a single system have enormous potential in cancer therapy. Herein, we present a novel and facile one-step method for the preparation of water-soluble single-walled carbon nanohorns (SWNHs) and metal phthalocyanines (MPc) hybrid for PTT and PDT. The hydrophilic MPc, tetrasulfonic acid tetrasodium salt copper phthalocyanine (TSCuPc), is coated on the surface of SWNHs via noncovalent π-π interaction using the sonication method. In this PTT/PDT nanosystem, SWNHs acts as a photosensitizer carrier and PTT agent, while TSCuPc acts as a hydrophilic and PDT agent. The EPR results demonstrated that the generated reactive oxygen species (ROS) not only from the photoinduced electron transfer process from TSCuPc to SWNHs but also from SWNHs without exciting TSCuPc to its excited state. The test of photothermal conversion proved that not only do SWNHs contribute to the photothermal therapy (PTT) effect, TSCuPc probably also contributes to that when it coats on the surface of SWNHs upon exposure to a 650-nm laser. More importantly, the results of in vitro cell viability revealed a significantly enhanced anticancer efficacy of combined noninvasive PTT/PDT, indicating that the SWNHs-TSCuPc nanohybrid is a hopeful candidate material for developing an efficient and biocompatible nanoplatform for biomedical application.
authors.affiliation: Ministry of Education Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University , Guilin 541004, People's Republic of China.
authors.forename: Bang-Ping
authors.initials: BP
authors.lastname: Jiang
authors.forename: Lan-Fang
authors.initials: LF
authors.lastname: Hu
authors.forename: Xing-Can
authors.initials: XC
authors.lastname: Shen
authors.forename: Shi-Chen
authors.initials: SC
authors.lastname: Ji
authors.forename: Zujin
authors.initials: Z
authors.lastname: Shi
authors.forename: Chan-Juan
authors.initials: CJ
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D002244:Carbon / Q000737:chemistry; D016923:Cell Death / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000627:therapeutic use* / Q000633:toxicity / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D038761:Photobleaching; D010778:Photochemotherapy; D056951:Photoelectron Spectroscopy; D010789:Phototherapy; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013818:Thermogravimetry; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D007211:Indoles; D054833:Isoindoles; D014867:Water; D002244:Carbon; C013647:phthalocyanine
keywords: metal phthalocyanine; photodynamic therapy; photothermal therapy; single-walled carbon nanohorns