title: Nail dystrophy, edema, and eosinophilia: harbingers of severe chronic GVHD of the skin in children.
abstract: The prognostic value of adnexal findings in chronic GVHD (cGVHD) has not been investigated in children. Dermatologic examinations were performed in a severe cohort of 11 children with skin cGVHD seen over a 2-year period. Findings were compared with 25 additional patients with skin cGVHD and 97 control patients. In 36 patients with skin cGVHD, nail dystrophy was present in 45% of patients, and was significantly associated with sclerotic disease and lung cGVHD. Pterygium inversum unguis (PIU) was associated with severe lung disease, with significantly lower % predicted FVC and FEV1 in those with PIU than those without. Forty-four percent of GVHD patients had preceding peripheral edema and 56% had preceding peripheral eosinophilia. Peripheral edema and eosinophilia were significantly associated with sclerotic cGVHD and persisted until the diagnosis of cGVHD in all patients. Comparison of data with control patients showed that incidence of nail dystrophy, incidence of peripheral edema and mean peak peripheral eosinophil count of patients with skin cGVHD was significantly higher than those without cGVHD. This study suggests that nail dystrophy, persistent peripheral edema and persistent peripheral eosinophilia are harbingers of severe cGVHD of the skin in children. The presence of PIU may be a harbinger of severe lung involvement.
authors.affiliation: Dermatology Program, Boston Children's Hospital, Boston, MA, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Huang
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: C N
authors.initials: CN
authors.lastname: Duncan
authors.affiliation: Division of Respiratory Diseases, Boston Children's Hospital, Boston, MA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Boyer
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: H
authors.initials: H
authors.lastname: Khosravi
authors.affiliation: Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: L E
authors.initials: LE
authors.lastname: Lehmann
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Saavedra
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004487:Edema / Q000473:pathology*; D004802:Eosinophilia / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D009262:Nails / Q000473:pathology*; D012871:Skin Diseases / Q000276:immunology / Q000473:pathology*; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome