title: Wine consumption throughout life is inversely associated with type 2 diabetes risk, but only in overweight individuals: results from a large female French cohort study.
abstract: Alcohol has previously been shown to have a U-shaped association with type 2 diabetes (T2D) risk, but less is known regarding the specific association with wine. To evaluate for the first time the associations between T2D risk and both baseline wine consumption and trajectories of wine consumption frequency throughout life, estimated using an innovative group-based trajectory modeling strategy. A total of 66,485 women from the French prospective E3N-EPIC cohort were followed between 1993 and 2007; 1,372 incident cases of T2D were diagnosed during the follow-up. Multivariable Cox regression models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (95 % CI) for T2D risk. The average consumption of wine, among alcohol consumers, was 0.81 drinks/day (1 drink = 150 mL). Associations between wine and T2D were restricted to overweight women (P interaction = 0.0084). Among them, wine consumption was inversely associated with T2D risk (P trend = 0.0022). A lower risk was observed for overweight women having two or more drinks/day [HR 0.59 (0.43-0.82)] when compared with non-alcohol consumers. Women who started to drink wine early in life (around age 10-15 years) were at a significantly lower risk than lifetime abstainers. In our study, wine drinking was inversely associated with T2D risk but only in overweight women. Our results also suggest a potential beneficial, cumulative effect of moderate wine consumption throughout life for overweight women, who would already be at higher risk of T2D. We encourage other cohort studies with information on wine consumption to investigate these associations.
authors.affiliation: Center for Research in Epidemiology and Population Health (CESP), INSERM (Institut National de la Santé et de la Recherche Médicale) U1018, Team 9, Nutrition, Hormones and Women's Health, Gustave Roussy Institute, 114 rue Edouard Vaillant, 94805, Villejuif Cedex, France, guy.fagherazzi@gustaveroussy.fr.
authors.forename: Guy
authors.initials: G
authors.lastname: Fagherazzi
authors.forename: Alice
authors.initials: A
authors.lastname: Vilier
authors.forename: Martin
authors.initials: M
authors.lastname: Lajous
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008019:Life Style; D015999:Multivariate Analysis; D050177:Overweight; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D012307:Risk Factors; D012959:Socioeconomic Factors; D014920:Wine