title: Cellulose-nanofiber/polygalacturonic acid coatings with high oxygen barrier and targeted release properties.
abstract: A bio-inspired coating consisting of pectin (polygalacturonic acid) and cationic cellulose nanofibers were successfully produced by the layer-by-layer method. The build-up and the morphology of the resulting coatings were studied with spectroscopic ellipsometry and atomic force microscopy, respectively. The coating was able to survive the exposure of a simulated gastric fluid, but was partially degraded upon exposure to pectinase enzyme, which simulate the action of the microbial symbionts present in the human colon. Prior to exposure, the oxygen permeability coefficient of the coating (0.033 ml(STP)mmm(-2)day(-1)atm(-1) at 23°C and 20% RH) was in the same order of magnitude as for ethylene vinyl alcohol films (0.001-0.01 ml(STP)mmm(-2)day(-1)atm(-1)). However, after exposure to the mimicked gastrointestinal (GI) tract conditions, the contribution of coating to the overall barrier properties was not measurable.
authors.affiliation: University of Copenhagen, Department of Chemistry, Universitetsparken 5, DK-2100 Copenhagen, Denmark.
authors.forename: Susanne L
authors.initials: SL
authors.lastname: Mølgaard
authors.affiliation: SP Technical Research Institute of Sweden, Department of Wood Technology, PO Box 5609, SE-114 86 Stockholm, Sweden.
authors.forename: Marielle
authors.initials: M
authors.lastname: Henriksson
authors.affiliation: University of Copenhagen, Department of Chemistry, Universitetsparken 5, DK-2100 Copenhagen, Denmark; Biomedical Laboratory Science, Faculty of Health and Society, Malmö University, SE-205 06 Malmö, Sweden. Electronic address: cardenas@nano.ku.dk.
authors.forename: Marité
authors.initials: M
authors.lastname: Cárdenas
authors.affiliation: University of Copenhagen, Inst. for Food Research, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark. Electronic address: asva@life.ku.dk.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Svagan
mesh_terms: D002482:Cellulose / Q000737:chemistry* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D057139:Nanofibers / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry* / Q000378:metabolism; D010368:Pectins / Q000737:chemistry* / Q000378:metabolism; D013499:Surface Properties
chemical_list: D010368:Pectins; D002482:Cellulose; D010100:Oxygen; C003181:polygalacturonic acid
keywords: Cellulose nanofibers; High oxygen barrier properties; Layer-by-layer coating; Targeted release