title: Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism.
abstract: BACKGROUND
  Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).
  
  
  METHODS
  The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.
  
  
  RESULTS
  The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P=0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.
  
  
  CONCLUSIONS
  The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_177.
authors.forename: Yiguo
authors.initials: Y
authors.lastname: Yan
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Hu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Lu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011475:Prosthesis Failure / Q000209:etiology*; D012307:Risk Factors; D017211:Treatment Failure
chemical_list: D020781:Matrix Metalloproteinase 1