title: Could cancer initiate from bone marrow progenitors?
abstract: Defining cancer stem cells and their origins is of much controversy,and constitutes a challenged knockout for cell targeting- anticancer drugs. Herein,we put forward a hypothetic model for cancer stem cells initiation from bone marrow stem cells. These later, will differentiate into an ancestral progenitor that activates a memorial program - the black box cassette- that is responsible of abnormal neo-organogenesis in the form of tumors and metastases. To approve this model, we assume that characterizing and investigating the most primitive forms of the bone marrow progenitors is required; both inside their niche and in circulation of cancer patients.
authors.affiliation: Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia.
authors.forename: Hmed
authors.initials: H
authors.lastname: Ben Nasr
authors.affiliation: Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia.
authors.forename: Serria Turky
authors.initials: ST
authors.lastname: Hammami
authors.affiliation: Dept. of Pharmacology, Medicine Faculty, Sfax University, Rue Magida Boulila, Sfax, Tunisia.
authors.forename: Khaled
authors.initials: K
authors.lastname: Zeghal
keywords: Bone marrow; Neoplasm; Origin; Progenitors