title: The role of molecular remodeling in differential regulation of tight junction permeability.
abstract: Tight junctions create a paracellular barrier that is essential for survival of complex organisms. In many cases tight junctions define separate, generally sterile, tissue compartments. In the skin and gut, tight junctions must also seal the paracellular space to prevent microbiota from accessing the internal milieu. This is a relatively simple task in the integument, where an absolute barrier is effective. However, intestinal epithelial tight junctions are charged with the far more complex task of supporting paracellular transport of water, ions, and nutrients while providing a barrier to microbial translocation. The delicate nature of this balance, which is disrupted in disease, makes the intestine a unique organ in which to explore the complexities of tight junction permeability and barrier regulation. Here we review recent progress in understanding the molecular determinants of barrier function and events responsible for regulation, and dysregulation, of tight junction permeability.
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland, MC1089, Chicago, IL 60637, USA. Electronic address: jrturner@uchicago.edu.
authors.forename: Jerrold R
authors.initials: JR
authors.lastname: Turner
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland, MC1089, Chicago, IL 60637, USA.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Buschmann
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland, MC1089, Chicago, IL 60637, USA.
authors.forename: Isabel
authors.initials: I
authors.lastname: Romero-Calvo
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland, MC1089, Chicago, IL 60637, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Sailer
authors.affiliation: Department of Pathology, The University of Chicago, 5841 South Maryland, MC1089, Chicago, IL 60637, USA.
authors.forename: Le
authors.initials: L
authors.lastname: Shen
mesh_terms: D057167:Claudins / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D062793:Occludin / Q000378:metabolism; D010539:Permeability; D019108:Tight Junctions / Q000502:physiology*
chemical_list: D057167:Claudins; D008565:Membrane Proteins; D062793:Occludin
keywords: Claudin; Leak pathway; Myosin light chain kinase; Occludin; Pore pathway; ZO-1