title: Mild and metal-free oxy- and amino-fluorination for the synthesis of fluorinated heterocycles.
abstract: A mild intramolecular fluoro-cyclisation reaction of benzylic alcohols and amines has been developed. This strategy uses commercially available Selectfluor to trigger electrophilic cyclisations to afford fluorinated heterocycles containing 1,3-disubstitution. The dual role of the reagent as a fluorine source and a base is shown to be crucial for reactivity.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074, Aachen, Germany. Magnus.Rueping@rwth-aachen.de.
authors.forename: Dixit
authors.initials: D
authors.lastname: Parmar
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping