title: Neurophysiological indices of atypical auditory processing and multisensory integration are associated with symptom severity in autism.
abstract: Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and (1) autism severity and (2) sensory sensitivities, in individuals with ASD aged 6-17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
authors.affiliation: Department of Pediatrics, The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC), Albert Einstein College of Medicine, 1225 Morris Park Avenue, Bronx, NY, 10461, USA.
authors.forename: Alice B
authors.initials: AB
authors.lastname: Brandwein
authors.forename: John J
authors.initials: JJ
authors.lastname: Foxe
authors.forename: John S
authors.initials: JS
authors.lastname: Butler
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Frey
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Bates
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Shulman
authors.forename: Sophie
authors.initials: S
authors.lastname: Molholm
mesh_terms: D000293:Adolescent; D001307:Auditory Perception / Q000502:physiology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005074:Evoked Potentials, Visual / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010468:Perceptual Disorders / Q000150:complications / Q000503:physiopathology*; D011930:Reaction Time; D012720:Severity of Illness Index; D014796:Visual Perception / Q000502:physiology*