title: Controlling bacterial behavior with indole-containing natural products and derivatives.
abstract: Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation. Intercepting indole-signaling pathways with appropriately designed small molecules provides a n opportunity to control unwanted bacterial behaviors, and is an attractive anti-virulence therapeutic strategy. In this review, we give an overview of the process controlled by indole signaling, and summarize current efforts to design indole-containing small molecules to intercept these pathways, and detail the synthetic efforts towards accessing indole derived bioactive small molecules.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC, 27695.
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Melander
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC, 27695.
authors.forename: Marine J
authors.initials: MJ
authors.lastname: Minvielle
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, NC, 27695.
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
keywords: Anti-virulence; Antibiotic resistance; Bacterial communication; Biofilm; Indole