title: Active drug release systems: current status, applications and perspectives.
abstract: Active drug release systems offer an important privilege to manage the dosage, time and sometimes site of drug release after the implantation procedure has been performed. Once developed, they could cover such applications as hormone therapy, implantation surgery, and delivery of immunization boosters. A number of existing approaches towards such systems include arrays of microreservoirs equipped with stimuli-responsive actuators or valves. The very first developed system has reached the stage of in-human trials recently. A breakthrough could happen if microreservoirs themselves are made of responsive material susceptible towards remote triggers. A promising candidate is a material made of Layer-by-Layer assembled films which currently are widely exploited only as passive implantable drug release systems.
authors.affiliation: Institute of Materials Research and Engineering, A*STAR, 3 Research Link, Singapore 117602, Singapore. Electronic address: kiryukhin-m@imre.a-star.edu.sg.
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Kiryukhin
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D019736:Prostheses and Implants
chemical_list: D020100:Hydrogels; D011108:Polymers