title: Study of the persistence of the anti-inflammatory effect observed after application of preparations containing organic ultraviolet filters.
abstract: Given that previous studies have highlighted the anti-inflammatory nature, which is influenced by UV radiation, of a certain number of ultraviolet filters currently used in Europe, it seemed interesting to evaluate the persistence of this type of effect. The persistence of the anti-inflammatory effect of fourteen preparations, each containing one of the ultraviolet filters authorized by Regulation (CE) No. 1223/2009, and of 10 commercially-available sun products was studied using the phorbol-myristate-acetate test on mice, up to 6 and a half hours after application. We can observe that a benzophenone, oxybenzone, a PABA derivative, octyldimethylPABA and a derivative of cinnamic acid, OMC as well as 3 commercially-available products, display a very marked anti-inflammatory effect at the end of our experimentation phase. The type of effect observed could encourage users to prolong the time that they are exposed to the sun, due to there being no warning signs, namely sunburn.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, GEP3, MMS, EA 2160, Faculty of Pharmacy, 9 rue Bias - Nantes, F-44000, France.
authors.forename: C
authors.initials: C
authors.lastname: Couteau
authors.affiliation: Pharmacochemistry Department, Faculty of Pharmacy, Nantes University, Nantes Atlantique Universities, IICiMed UPRES EA 1155, Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Chauvet
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, GEP3, MMS, EA 2160, Faculty of Pharmacy, 9 rue Bias - Nantes, F-44000, France.
authors.forename: E
authors.initials: E
authors.lastname: Paparis
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, GEP3, MMS, EA 2160, Faculty of Pharmacy, 9 rue Bias - Nantes, F-44000, France. Electronic address: laurence.coiffard@univ-nantes.fr.
authors.forename: L J M
authors.initials: LJ
authors.lastname: Coiffard
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013473:Sunscreening Agents / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D000893:Anti-Inflammatory Agents; D013473:Sunscreening Agents; D013755:Tetradecanoylphorbol Acetate
keywords: Anti-inflammatory effect; Persistence of the effect; Skin; Sun products; UV filters