title: Transient elevation of cerebrospinal fluid protein in a patient of mild encephalitis with reversible lesion in the splenium: a case report.
abstract: Mild encephalitis with reversible lesion in the splenium (MERS) is a clinicoradiological syndrome presenting as a solitary lesion in the central portion of the splenium of the corpus callosum (SCC) with a radiological finding of restricted diffusion and low apparent diffusion coefficient (ADC) values. Complete resolution of the lesion on follow-up imaging and full clinical recovery are the hallmarks of this syndrome, even with only supportive therapy. MERS is usually associated with normal Cerebrospinal fluid (CSF) findings and an excellent prognosis, even without corticosteroid therapy. Magnetic resonance imaging (MRI) is the ideal modality for initial diagnosis and follow-up. Not many cases of this uncommon clinicoradiological syndrome with transient elevation of CSF proteins have been reported. In the subsequent sections, we present a case report of this unusual clinicoradiological entity with raised CSF protein. We also elaborate on possible differential diagnoses and the syndrome's proposed pathophysiology.
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, PIN: 302004.
authors.forename: Bhawna
authors.initials: B
authors.lastname: Sharma
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, PIN: 302004.
authors.forename: Rahul
authors.initials: R
authors.lastname: Handa
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, PIN: 302004.
authors.forename: Kadam
authors.initials: K
authors.lastname: Nagpal
authors.affiliation: Department of Neurology, Sawai Man Singh Medical College, Jaipur, Rajasthan, PIN: 302004.
authors.forename: Swayam
authors.initials: S
authors.lastname: Prakash
authors.affiliation: Rajasthan University of Health Sciences (RUHS), Jaipur, Rajasthan, PIN: 302033.
authors.forename: Ashok
authors.initials: A
authors.lastname: Panagariya
keywords: cerebrospinal fluid protein; corpus callosum; diffusion magnetic resonance imaging; encephalitis; reversible lesion; splenium