title: [Advance in studies on neuroprotective mechanism of Uncariae Ramulus Cum Uncis].
abstract: The Uncariae Ramulus Cum Uncis is a commonly used traditional Chinese medicine. In recent years, many studies have revealed its prominent neuroprotection function. The active ingredients in Uncariae Ramulus Cum Uncis could protect the nervous system in a multi-path and multi-target manner. Uncariae Ramulus Cum Uncis shows the neuroprotective effect by resisting oxidation, scavenging free radicals, modulating neurotransmitters and their related receptors, regulating the inflammatory factors and their related pathways, attenuating neuron apoptosis, reducing intracellular Ca2+ overloads and mitigating neurodegeneration. In this paper, the authors summarized the advance in studies on neuroprotective mechanisms of Uncariae Ramulus Cum Uncis.
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Wei
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Zeng
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D032070:Uncaria / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D018836:Inflammation Mediators; D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents; D002118:Calcium