title: Preparation of polyelectrolyte/calcium phosphate hybrids for drug delivery application.
abstract: Biocompatible and biodegradable polyelectrolyte complex consisting of carboxylmethyl cellulose (CMC) and chitosan (CHI) were studied as a template for calcium phosphate biomimetic mineralization. CMC/CHI/calcium phosphate hybrids were prepared using different concentrations of simulated body fluid (2, 5 and 10 × SBF) for producing hybrids with different organic/inorganic ratio. These hybrids were characterized using X-ray diffraction (XRD), infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). The equilibrium swelling extents of the hybrids were found to be dependent on the inorganic % in the hybrids. The release profile of bovine serum albumin as a model drug in simulated intestine solution (pH 7.4) during 24h has established the efficiency of the hybrids as a sustained delivery system. The hybrids developed in this contribution exhibit a great potential in bone tissue engineering and drug delivery applications.
authors.affiliation: Cellulose and Paper Department, National Research Center, El-Tahrir Street, Dokki, Cairo, Egypt. Electronic address: ahmed_nigm78@yahoo.com.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Salama
authors.affiliation: Cellulose and Paper Department, National Research Center, El-Tahrir Street, Dokki, Cairo, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Sakhawy
mesh_terms: D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry*; D002417:Cattle; D002482:Cellulose / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D016503:Drug Delivery Systems; D004573:Electrolytes / Q000737:chemistry; D006801:Humans; D011108:Polymers / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry*; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D004573:Electrolytes; D011108:Polymers; D012710:Serum Albumin, Bovine; D002482:Cellulose; D048271:Chitosan; C020243:calcium phosphate
keywords: Calcium phosphate; Carboxymethyl cellulose; Chitosan; Drug delivery; Hybrid; Polyelectrolyte