title: Early and mid-term results of lung transplantation with donors 60 years and older.
abstract: OBJECTIVE
  There are doubts about the age limit for lung donors and the ideal donor has traditionally been considered to be one younger than 55 years. The objective of this study was to compare the outcomes in lung transplantation between organs from donors older and younger than 60 years.
  
  
  METHODS
  We performed a retrospective observational study comparing the group of patients receiving organs from donors 60 years or older (Group A) or younger than 60 years (Group B) between January 2007 and December 2011. Postoperative evolution and mortality rates, short-term and mid-term postoperative complications, and global survival rate were evaluated.
  
  
  RESULTS
  We analysed a total of 230 lung transplants, of which 53 (23%) involved lungs from donors 60 years of age or older (Group A), and 177 (77%) were from donors younger than 60 years (Group B). Three (5.7%) patients from Group A and 14 patients (7.9%) from Group B died within 30 days (P = 0.58). The percentage of patients free from chronic lung allograft dysfunction at 1-3 years was 95.5, 74.3 and 69.3% for Group A, and 94.5, 84.8 and 73.3% for Group B, respectively (P = 0.47). There were no statistically significant differences between Groups A and B in terms of survival at 3 years, (69.4 vs 68.8%; P = 0.28).
  
  
  CONCLUSIONS
  Our results support the idea that lungs from donors aged 60-70 years can be used safely for lung transplantation with comparable results to lungs from younger donors in terms of postoperative mortality and mid-term survival.
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain ilopezsanz@gmail.com.
authors.forename: Iker
authors.initials: I
authors.lastname: López
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Zapata
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Solé
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Jaúregui
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Deu
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Romero
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Pérez
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Bello
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Wong
authors.affiliation: Department of Anesthesiology, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Montse
authors.initials: M
authors.lastname: Ribas
authors.affiliation: Critical Care Department, Vall d'Hebron University Hospital, Barcelona, Spain Transplant Coordination Department, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Masnou
authors.affiliation: Critical Care Department, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Rello
authors.affiliation: Department of Pulmonology, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Antonio
authors.initials: A
authors.lastname: Roman
authors.affiliation: Department of Thoracic Surgery, Lung Transplant Unit, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Canela
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D046148:Donor Selection; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
keywords: Donor age; Expanded criteria donors; Lung donors; Lung transplantation; Safety of organs