title: Risk factors for suicide in bipolar disorder: a systematic review.
abstract: BACKGROUND
  Bipolar disorder confers the highest risk of suicide among major psychological disorders. The risk factors associated with bipolar disorder and suicide exist and are relevant to clinicians and researchers.
  
  
  OBJECTIVE
  The aim of the present study was to conduct a systematic review of articles regarding the suicide risk factors in bipolar disorder.
  
  
  METHODS
  A systematic review of articles on suicide risk factors in bipolar disorder, published from January 1, 2010 to April 05, 2014, on SCOPUS and PUBMED databases was carried out. Search terms were "Suicide" (medical subject headings [MeSH]), "Risk factors" (MeSH), and "Bipolar" (keyword). Of the 220 retrieved studies, 42 met the eligibility criteria.
  
  
  RESULTS
  Bipolar disorder is associated with an increased rate death by suicide which contributes to overall mortality rates. Studies covered a wide range of aspects regarding suicide risk factors in bipolar disorder, such as risk factors associated to Sociodemographic conditions, Biological characteristics, Drugs Relationships, Psychological Factors, Genetic Compound, Religious and Spirituals conditions. Recent scientific literature regarding the suicide risk factors in bipolar disorder converge to, directly or indirectly, highlight the negative impacts of risk factors to the affected population quality of life.
  
  
  CONCLUSIONS
  This review demonstrated that Bipolar disorders commonly leads to other psychiatric disorders and co-morbidities involving risk of suicide. Thus the risk factors are relevant to have a better diagnosis and prognosis of BD cases involving risk of suicide.
authors.affiliation: Laboratório de Escrita Científica, Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil. Electronic address: lucas_10_00@hotmail.com.
authors.forename: Lucas da Silva
authors.initials: Lda S
authors.lastname: Costa
authors.affiliation: Laboratório de Escrita Científica, Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Átila Pereira
authors.initials: ÁP
authors.lastname: Alencar
authors.affiliation: Laboratório de Escrita Científica, Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Pedro Januário
authors.initials: PJ
authors.lastname: Nascimento Neto
authors.affiliation: Laboratório de Escrita Científica, Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Maria do Socorro Vieira
authors.initials: Mdo S
authors.lastname: dos Santos
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Cláudio Gleidiston Lima
authors.initials: CG
authors.lastname: da Silva
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Sally de França Lacerda
authors.initials: Sde F
authors.lastname: Pinheiro
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Regiane Teixeira
authors.initials: RT
authors.lastname: Silveira
authors.affiliation: Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, São Paulo, Brazil.
authors.forename: Bianca Alves Vieira
authors.initials: BA
authors.lastname: Bianco
authors.affiliation: Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Roberto Flávio Fontenelle
authors.initials: RF
authors.lastname: Pinheiro
authors.affiliation: Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Marcos Antonio Pereira
authors.initials: MA
authors.lastname: de Lima
authors.affiliation: Programa de Pós-Graduação em Saúde Pública, Faculdade de Saúde Pública, Universidade de São Paulo, USP, São Paulo, São Paulo, Brazil.
authors.forename: Alberto Olavo Advincula
authors.initials: AO
authors.lastname: Reis
authors.affiliation: Líder de Grupo de Pesquisa em Suicidologia, Universidade Federal do Ceará, UFC/Conselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Faculdade de Medicina, Universidade Federal do Cariri, UFCA, Barbalha, Ceará, Brazil.
authors.forename: Modesto Leite
authors.initials: ML
authors.lastname: Rolim Neto
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics / Q000401:mortality / Q000523:psychology*; D006801:Humans; D012307:Risk Factors; D013405:Suicide / Q000523:psychology* / Q000706:statistics & numerical data
keywords: Bipolar; Risk factors; Suicide