title: MPT64 polymorphisms of Mycobacterium tuberculosis strains suggest ongoing immune evasion.
abstract: In our previous study, we found that polymorphisms of the mpt64 gene in the Mycobacterium tuberculosis complex (MTBC) may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions. Based on the data, we further analyzed T/B cell epitope regions and non-epitope regions and compared amino acid changes between them. It turned out the polymorphisms of MPT64 affected both T cell epitopes and B cell epitopes, which thus influenced cell-mediated immunity and humoral immunity at the same time. Both T cell epitope regions and B cell epitope regions had higher dN/dS values than corresponding non-epitope regions, which means the formers have accumulated significantly more amino acid changes than the latters.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China.
authors.forename: Haican
authors.initials: H
authors.lastname: Liu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou 310003, PR China. Electronic address: wankanglin@icdc.cn.
authors.forename: Kanglin
authors.initials: K
authors.lastname: Wan
mesh_terms: D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial
keywords: Immune evasion; MPT64 polymorphisms; Mycobacterium tuberculosis