title: New semi-biodegradable materials from semi-interpenetrated networks of poly(ϵ-caprolactone) and poly(ethyl acrylate).
abstract: Semi-degradable materials may have many applications. Here poly(ethyl acrylate) and poly(ϵ-caprolactone) were combined as semi-interpenetrated networks, and thoroughly characterized in terms of final composition, interactions between components, wettability, and mechanical properties. PCL modulates the mechanical properties of the PEA elastomeric network. Cultures of fibroblasts and adipose-tissue derived stem cells showed excellent biological performance of the materials. The results are relevant for applications seeking materials leaving a permanent supporting skeleton after the partial degradation, as in patches for cardiac regeneration or in abdominal wall meshes.
authors.affiliation: Center for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Cno. de Vera s/n, 46022, Valencia, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Lozano Picazo
authors.forename: M
authors.initials: M
authors.lastname: Pérez Garnes
authors.forename: C
authors.initials: C
authors.lastname: Martínez Ramos
authors.forename: A
authors.initials: A
authors.lastname: Vallés-Lluch
authors.forename: M
authors.initials: M
authors.lastname: Monleón Pradas
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry*; D001709:Biotechnology / Q000379:methods*; D002152:Calorimetry, Differential Scanning; D002460:Cell Line; D004146:Dioxanes; D007150:Immunohistochemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D012756:Sheep; D017550:Spectroscopy, Fourier Transform Infrared; D013718:Tensile Strength; D013778:Tetrazolium Salts; D013818:Thermogravimetry; D013844:Thiazoles; D017155:Wettability
chemical_list: D000180:Acrylic Resins; D063566:Biodegradable Plastics; D004146:Dioxanes; D011091:Polyesters; D013778:Tetrazolium Salts; D013844:Thiazoles; C478961:poly(ethylacrylate); C016240:polycaprolactone; C022616:thiazolyl blue; C025223:1,4-dioxane
keywords: biocompatibility; poly(ethyl acrylate); poly(ϵ-caprolactone); semi-degradable; semi-interpenetrating network