title: [Drug induced hepatotoxicity in targeted therapy for lung cancer].
abstract: Targeted drugs aimed at driver gene, such as Gefitinib, Erlotinib and Crizotinib, have an irreplaceable position in the therapy of advanced non-small cell lung cancer. These drugs bring benefit to patients, however, higher hepatotoxicity is also presented. Now, drug induced hepatotoxicity and its mechanism are reviewed.
authors.affiliation: Department of Medical Oncology, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, Hangzhou 310006, China.
authors.forename: Xueqin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Medical Oncology, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, Hangzhou 310006, China.
authors.forename: Shaoyu
authors.initials: S
authors.lastname: Yang
authors.affiliation: Department of Medical Oncology, Affiliated Hangzhou Hospital (Hangzhou First People's Hospital), Nanjing Medical University, Hangzhou 310006, China.
authors.forename: Shenglin
authors.initials: S
authors.lastname: Ma
mesh_terms: D006801:Humans; D008099:Liver / Q000187:drug effects*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D011110:Polymorphism, Genetic; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D047428:Protein Kinase Inhibitors