title: Single-molecule study of proteins by biological nanopore sensors.
abstract: Nanopore technology has been developed for detecting properties of proteins through monitoring of ionic current modulations as protein passes via a nanosize pore. As a real-time, sensitive, selective and stable technology, biological nanopores are of widespread concern. Here, we introduce the background of nanopore researches in the area of α-hemolysin (α-HL) nanopores in protein conformation detections and protein-ligand interactions. Moreover, several original biological nanopores are also introduced with various features and functions.
authors.affiliation: College of Pharmacy, Jiamusi University, Jiamusi 154007, China. dmwu@jmsu.edu.cn.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.affiliation: The Affiliated First Hospital of Jiamusi University, Jiamusi 154007, China. Bishengbs_1981@126.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Bi
authors.affiliation: College of Pharmacy, Jiamusi University, Jiamusi 154007, China. zhangliyuzly@gmail.com.
authors.forename: Liyu
authors.initials: L
authors.lastname: Zhang
authors.affiliation: The Affiliated First Hospital of Jiamusi University, Jiamusi 154007, China. Yangj2004@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
mesh_terms: D015374:Biosensing Techniques; D006460:Hemolysin Proteins / Q000737:chemistry*; D008024:Ligands; D008051:Lipid Bilayers / Q000737:chemistry*; D058608:Nanopores; D011487:Protein Conformation
chemical_list: D006460:Hemolysin Proteins; D008024:Ligands; D008051:Lipid Bilayers