title: NLRC4 gets out of control.
abstract: The NLRC4 inflammasome mediates the rapid release of proinflammatory cytokines in response to various microbial stimuli, but its role in the pathology of human diseases remains unknown. Two new studies now report gain-of-function mutations in the NLRC4 gene that cosegregate with distinct autoinflammatory syndromes in affected families.
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Hanif Javanmard
authors.initials: HJ
authors.lastname: Khameneh
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mortellaro
mesh_terms: D053468:CARD Signaling Adaptor Proteins / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D004760:Enterocolitis / Q000235:genetics*; D005260:Female; D006801:Humans; D058847:Inflammasomes / Q000235:genetics*; D007249:Inflammation / Q000235:genetics*; D055501:Macrophage Activation Syndrome / Q000235:genetics*; D008297:Male; D020125:Mutation, Missense
chemical_list: D053468:CARD Signaling Adaptor Proteins; D002135:Calcium-Binding Proteins; D058847:Inflammasomes; C435692:NLRC4 protein, human