title: Necrotizing myopathy as a paraneoplastic syndrome associated with renal cell carcinoma.
abstract: We report a 49-year-old patient with necrotizing myopathy and a right renal mass. After laparoscopic radical nephrectomy, a remission of myopathy was seen. Pathologic evaluation of the nephrectomy specimen revealed a clear cell renal cell carcinoma. Relapse of myopathy 6 months postoperatively coincided with the diagnosis of the appearance of liver metastatic disease. After initiation of treatment with an mTOR-inhibitor, myopathy became less active requiring smaller amounts of corticosteroids with a complete remission of myopathy after 3 months of systemic treatment for metastatic renal cell cancer.
authors.forename: E
authors.initials: E
authors.lastname: Naert
authors.forename: J L
authors.initials: JL
authors.lastname: De Bleecker
authors.forename: N
authors.initials: N
authors.lastname: Lumen
authors.forename: S
authors.initials: S
authors.lastname: Rottey
mesh_terms: D002292:Carcinoma, Renal Cell / Q000150:complications*; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D009336:Necrosis; D010257:Paraneoplastic Syndromes / Q000209:etiology*
keywords: Cancer-associated myositis,; Carcinoma,; Necrotizing myopathy; Paraneoplastic syndrome,; Renal cell,