title: Escherichia coli carbon source metabolism affects longevity of its predator Caenorhabditis elegans.
abstract: Nutrition is probably the most determinant factor affecting aging. Microorganisms of the intestinal flora lay in the interface between available nutrients and nutrients that are finally absorbed by multicellular organisms. They participate in the processing and transformation of these nutrients in a symbiotic or commensalistic relationship. In addition, they can also be pathogens. Alive Escherichia coli OP50 are usually used to culture the bacteriovorus nematode Caenorhabditis elegans. Here, we report a beneficial effect of low concentration of saccharides on the longevity of C. elegans. This effect is only observed when the bacterium can metabolize the sugar, suggesting that physiological changes in the bacterium feeding on the saccharides are the cause of this beneficial effect.
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas - Universidad Pablo de Olavide, Carretera de Utrera, km1, Seville 41013, Spain.
authors.forename: Ana María
authors.initials: AM
authors.lastname: Brokate-Llanos
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas - Universidad Pablo de Olavide, Carretera de Utrera, km1, Seville 41013, Spain.
authors.forename: Andrés
authors.initials: A
authors.lastname: Garzón
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas - Universidad Pablo de Olavide, Carretera de Utrera, km1, Seville 41013, Spain. Electronic address: mmunrui@upo.es.
authors.forename: Manuel J
authors.initials: MJ
authors.lastname: Muñoz
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D002241:Carbohydrates / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*
chemical_list: D002241:Carbohydrates
keywords: Caenorhabditis elegans; Escherichia coli; Lifespan; Metabolism; Pathogenicity; Sugar