title: DNA cleavage, antibacterial, antifungal and anthelmintic studies of Co(II), Ni(II) and Cu(II) complexes of coumarin Schiff bases: synthesis and spectral approach.
abstract: The metal complexes of Co(II), Ni(II) and Cu(II) have been synthesized from 6-formyl-7,8-dihydroxy-4-methylcoumarin with o-toluidine/3-aminobenzotrifluoride. The synthesized Schiff bases and their metal complexes were structurally characterized based on IR, (1)H NMR, (13)C NMR, UV-visible, ESR, magnetic, thermal, fluorescence, mass and ESI-MS studies. The molar conductance values indicate that complexes are non-electrolytic in nature. Elemental analysis reveals ML2·2H2O [M = Co(II), Ni(II) and Cu(II)] stoichiometry, where 'L' stands for a singly deprotonated ligand. The presence of co-ordinated water molecules were confirmed by thermal studies. The spectroscopic studies suggest the octahedral geometry. Redox behavior of the complexes were confirmed by cyclic voltammetry. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Pseudomonas auregenosa, klebsiella, Proteus, Staphylococcus aureus and salmonella) antifungal (Candida, Aspergillus niger and Rhizopus), anthelmintic (Pheretima posthuma) and DNA cleavage (Calf Thymus DNA) activity.
authors.affiliation: Department of Chemistry, Karnatak University, Dharwad, Karnataka, India. Electronic address: patil1956@rediffmail.com.
authors.forename: Sangamesh A
authors.initials: SA
authors.lastname: Patil
authors.affiliation: Department of Chemistry, Karnatak University, Dharwad, Karnataka, India.
authors.forename: Chetan T
authors.initials: CT
authors.lastname: Prabhakara
authors.affiliation: Department of Chemistry, Karnatak University, Dharwad, Karnataka, India.
authors.forename: Bhimashankar M
authors.initials: BM
authors.lastname: Halasangi
authors.affiliation: Department of Chemistry, Karnatak University, Dharwad, Karnataka, India.
authors.forename: Shivakumar S
authors.initials: SS
authors.lastname: Toragalmath
authors.affiliation: Department of Chemistry, S.S. Kuba College of Science, Basavakalyan, Karnataka, India.
authors.forename: Prema S
authors.initials: PS
authors.lastname: Badami
mesh_terms: D000588:Amines / Q000737:chemistry; D000871:Anthelmintics / Q000737:chemistry; D000890:Anti-Infective Agents / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D053837:DNA Cleavage / Q000187:drug effects*; D006859:Hydrogen / Q000737:chemistry; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D009532:Nickel / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D000588:Amines; D000871:Anthelmintics; D000890:Anti-Infective Agents; D003374:Coumarins; D008024:Ligands; D012545:Schiff Bases; D003035:Cobalt; D002244:Carbon; D003300:Copper; D009532:Nickel; D006859:Hydrogen; D004247:DNA; C030123:coumarin; D009584:Nitrogen
keywords: Anthelmintic; Coumarin; DNA cleavage; Metal complexes; Schiff base; Thermal