title: Immunogenetics and immunology of transplantation in Leiden.
abstract: The historical observation of Jon van Rood that pregnancy can lead to the induction of HLA antibodies (1) was the start of a long history of research on immunogenetics and immunology of transplantation in Leiden. Some of the current research topics are presented in this mini-review. These include amongst others the differential immunogenicity of HLA mismatches in clinical transplantation, a special strategy to transplant highly sensitized patients, new tools to monitor donor specific memory B cells, new parameters for risk assessment in transplant recipients and the importance of the innate immune response in transplantation.
authors.affiliation: Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Heidt
authors.affiliation: Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
authors.forename: Michael
authors.initials: M
authors.lastname: Eikmans
authors.affiliation: Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
authors.forename: Dave L
authors.initials: DL
authors.lastname: Roelen
authors.affiliation: Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
authors.forename: Cees
authors.initials: C
authors.lastname: van Kooten
authors.affiliation: Leiden University Medical Center, Department of Immunohematology and Blood Transfusion, Albinusdreef 2, 2333 ZA Leiden, The Netherlands; Leiden University Medical Center, Department of Nephrology, Albinusdreef 2, 2333 ZA Leiden, The Netherlands. Electronic address: fhjclaas@lumc.nl.
authors.forename: Frans H J
authors.initials: FH
authors.lastname: Claas
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007125:Immunogenetics; D009426:Netherlands; D009927:Tissue and Organ Procurement; D014180:Transplantation
chemical_list: D006680:HLA Antigens
keywords: Antibodies; Complement; Dendritic cells; HLA; Memory B cells; Risk profile; Transplantation