title: Atypical meningoma: current management dilemmas and prospective clinical trials.
abstract: Atypical meningioma is an intermediate grade tumour with a greater risk of recurrence following surgical resection. Changes to the WHO classification have resulted in an increased reporting of these tumours. The role of early adjuvant radiotherapy after gross total resection has not been clearly defined and the literature evidence is of poor quality providing conflicting information. This review assesses the evidence for current clinical practice, management dilemmas and the need for prospective clinical trials for atypical meningioma.
authors.affiliation: Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, L9 7LJ, UK, michael.jenkinson@liv.ac.uk.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Jenkinson
authors.forename: Damien C
authors.initials: DC
authors.lastname: Weber
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Haylock
authors.forename: Conor L
authors.initials: CL
authors.lastname: Mallucci
authors.forename: Rasheed
authors.initials: R
authors.lastname: Zakaria
authors.forename: Mohsen
authors.initials: M
authors.lastname: Javadpour
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D008577:Meningeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D008579:Meningioma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018714:Radiotherapy, Adjuvant