title: Mortality prediction by acute kidney injury biomarkers in comparison with serum creatinine.
abstract: OBJECTIVE
  To investigate the performance of acute kidney injury (AKI) biomarkers for mortality prediction.
  
  
  METHODS
  Cutoff values of urinary L-type fatty acid-binding protein (L-FABP) and N-acetyl-β-d-glucosaminidase (NAG) for AKI diagnosis in ICU were determined in the derivation cohort. The performance of these AKI biomarkers for mortality prediction was evaluated in the validation cohort with stratification of serum-creatinine based AKI diagnosis.
  
  
  RESULTS
  Mortality in the AKI patients diagnosed by serum creatinine was increased remarkably when urinary L-FABP and NAG were positive.
  
  
  CONCLUSIONS
  These AKI biomarkers can specifically detect high-risk patients among creatinine-base diagnosed AKI.
authors.affiliation: Department of Emergency and Critical Care Medicine and.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hiruma
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Asada
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Ryota
authors.initials: R
authors.lastname: Inokuchi
authors.forename: Takehiro
authors.initials: T
authors.lastname: Matsubara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.forename: Maki
authors.initials: M
authors.lastname: Sumida
authors.forename: Rei
authors.initials: R
authors.lastname: Isshiki
authors.forename: Kengo
authors.initials: K
authors.lastname: Mayumi
authors.forename: Eisei
authors.initials: E
authors.lastname: Noiri
authors.forename: Masaomi
authors.initials: M
authors.lastname: Nangaku
authors.forename: Naoki
authors.initials: N
authors.lastname: Yahagi
authors.forename: Kent
authors.initials: K
authors.lastname: Doi
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000401:mortality*; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D003404:Creatinine
keywords: Intensive care units; L-type fatty acid-binding protein; N-acetyl-β-d-glucosaminidase