title: Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial.
abstract: This preliminary randomized study investigated the efficacy of medicinal mushrooms, Trametes versicolor (TV), Ganoderma lucidum (GL), and Laetiporus sulphureus (LS), on the clearance of oral human papillomavirus (HPV, serotypes 16 and 18). Among 472 patients who underwent oral swabs for gingivitis, 61 patients were positive for HPV16 or HPV18. Twenty patients were included in group 1 (LS) and 41 patients were included in group 2 (TV+GL) for 2 months. Polymerase chain reaction (PCR) for HPV was performed at inclusion and after 2 months. In group 1, the clearance was equal to 5% after 2 months of treatment. In group 2, the clearance was equal to 88% (P<0.001). The detection of HPV16 or HPV18 could become relevant in routine since positivity is frequent and because a harmless and costless treatment may exist. The use of TV+GL for the clearance of oral HPV deserves further investigation.
authors.affiliation: Medicine Information Formation, 40 rue du Dr Roux, 51350 Cormontreuil, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Donatini
mesh_terms: D000287:Administration, Topical; D000998:Antiviral Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D055453:Coriolaceae / Q000737:chemistry; D004279:DNA, Viral / Q000302:isolation & purification; D005260:Female; D005891:Gingivitis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D020940:Reishi / Q000737:chemistry*; D055454:Trametes / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral