title: [Hereditary angioedema: strange cause of abdominal pain].
abstract: BACKGROUND
  Hereditary angioedema is an episodic swelling disorder with autosomal dominant inheritance characterized by sudden attacks of peripheral swelling. Patients also commonly have episodic swelling of the wall of hollow viscera, including the bowel.
  
  
  METHODS
  We present a 33-year-old previously healthy male with a complaint of acute-onset intense abdominal pain localized in the epigastrium. Pain irradiated to the right lower quadrant and was associated with five episodes of vomiting. Computed tomography showed thickening of the duodenal wall with liquid in the subphrenic space. Complementary laboratory tests showed low C4 complement levels (5.5 mg/dl) and 30% complement C1 inhibitor activity.
  
  
  CONCLUSIONS
  Hereditary angioedema is caused by a deficiency (type I) or dysfunction (type II) in complement C1 inhibitor. Abdominal associated with angioedema may manifest as severe acute-onset abdominal pain or as moderately severe chronic recurrent abdominal pain. Two medications are currently FDA-approved for the treatment of these patients.
authors.affiliation: Servicio de Gastroenterología, Hospital Español de México, México, DF, Mexico. nereosalas@gmail.com.
authors.forename: Nereo Guillermo
authors.initials: NG
authors.lastname: Salas-Lozano
authors.affiliation: Servicio de Gastroenterología, Hospital Español de México, México, DF, Mexico.
authors.forename: Javier
authors.initials: J
authors.lastname: Meza-Cardona
authors.affiliation: Servicio de Gastroenterología, Hospital Español de México, México, DF, Mexico.
authors.forename: Coty
authors.initials: C
authors.lastname: González-Fernández
authors.affiliation: Servicio de Gastroenterología, Hospital Español de México, México, DF, Mexico.
authors.forename: Laura
authors.initials: L
authors.lastname: Pineda-Figueroa
authors.affiliation: Servicio de Gastroenterología, Hospital Español de México, México, DF, Mexico.
authors.forename: Mauricio
authors.initials: M
authors.lastname: de Ariño-Suárez
mesh_terms: D015746:Abdominal Pain / Q000209:etiology*; D000328:Adult; D050718:Complement C1 Inhibitor Protein / Q000032:analysis; D004386:Duodenum / Q000000981:diagnostic imaging / Q000473:pathology; D056829:Hereditary Angioedema Types I and II / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed
chemical_list: D050718:Complement C1 Inhibitor Protein
keywords: Hereditary angioedema; abdominal pain; angioedema hereditario; autosomal dominant; autosómico dominante; complement C1 inhibitor; dolor abdominal; inhibidor C1 del complemento