title: Argyrophilic proteins of nucleolar organizer regions and proliferative activity of cells in squamous cell carcinoma of the lung.
abstract: Argyrophilic proteins associated with nucleolar organizer regions (Ag-NOR proteins) and Ki-67 antigen were analyzed in 118 samples of squamous cell carcinoma of the lungs. Tumors with low and high content of Ag-NOR proteins and Ki-67 index were selected. It was found that the content of Ag-NOR proteins correlated with some clinical and morphological parameters (indexes T and N, tumor size less and more that 3 cm, stage of the disease, and tumor differentiation degree) and survival rate. High survival was associated with low content of Ag-NOR proteins and Ki-67 index and low survival correlated with high content of Ag-NOR proteins and Ki-67 index, while intermediate survival was associated with opposite values of Ag-NOR protein content and Ki-67 index. The tumor size, parameter N, and the content of Ag-NOR proteins had independent effects on patient's survival. In patients with squamous cell carcinoma of the lung without metastases in lymph nodes, survival correlated with the content of Ag-NOR proteins; in patients without metastases, survival correlated with tumor size.
authors.affiliation: Altai Branch of N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Barnaul, Russia, pathol@soramn.ru.
authors.forename: D S
authors.initials: DS
authors.lastname: Kobyakov
authors.forename: V V
authors.initials: VV
authors.lastname: Klimachev
authors.forename: A M
authors.initials: AM
authors.lastname: Avdalyan
authors.forename: I P
authors.initials: IP
authors.lastname: Bobrov
authors.forename: E Yu
authors.initials: EY
authors.lastname: Bychkova
authors.forename: N M
authors.initials: NM
authors.lastname: Kruglova
authors.forename: A F
authors.initials: AF
authors.lastname: Lazarev
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D049109:Cell Proliferation; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009697:Nucleolus Organizer Region / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins