title: [Ovulation induction by pulsatile GnRH therapy in 2014: literature review and synthesis of current practice].
abstract: The hypogonadotropic hypogonadism is an easily treatable form of female infertility. The most common cause of hypogonadotropic hypogonadism is functional hypothalamic amenorrhea. The GnRH pump is a simple and effective treatment to restore fertility of patients with hypothalamic amenorrhea: cumulative pregnancy rate is estimated between 70 and 100% after 6 cycles, compared to a low rate of complications and multiple pregnancies. While only 2.8 cycles are on average required to achieve a pregnancy with a pump, this induction of ovulation stays underused in France. The objective of this paper is to propose a practical manual of pulsatile GnRH, in order to improve the accessibility of pulsatile GnRH for patients with hypogonadotropic hypogonadism.
authors.affiliation: Service de gynécologie-obstétrique et médecine de la reproduction, centre hospitalier inter-communal de Poissy St-Germain, 10, rue Champ-Gaillard, 78303 Poissy cedex, France. Electronic address: drgronier@gmail.com.
authors.forename: H
authors.initials: H
authors.lastname: Gronier
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Peigné
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Catteau-Jonard
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Dewailly
authors.affiliation: Service de gynécologie endocrinienne et médecine de la reproduction, centre hospitalier régional universitaire de Lille, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Robin
mesh_terms: D005260:Female; D005602:France; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007006:Hypogonadism / Q000150:complications; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy
chemical_list: D007987:Gonadotropin-Releasing Hormone
keywords: Aménorrhée hypothalamo-hypophysaire; Hypothalamic amenorrhea; Induction de l’ovulation; Ovulation induction; Pompe à GnRH; Pulsatile GnRH