title: Patents on potential drugs to treat Alzheimer's disease: special emphasis on small peptides.
abstract: The primary objective of this article is to review patents and the related scientific work on naturally occurring compounds, heterocyclic compounds and small peptides that are being explored for their utility for the treatment of Alzheimer's disease (AD). In this review, a special emphasis is given to the patents, including our patent issued in 2013, on peptides that bind to A. Utility of the peptides that prevent aggregation or those that help in clearance of Aβ is discussed as the latter can be considered as an important arm in combination therapy for AD.
authors.forename: Pazhani
authors.initials: P
authors.lastname: Sundaram
authors.forename: Aravind K
authors.initials: AK
authors.lastname: Nambiar
authors.affiliation: Recombinant Technologies, LLC, 1090 Meriden Waterbury Road, Suite 1, Cheshire, CT 06410, USA.
authors.forename: Ranjini K
authors.initials: RK
authors.lastname: Sundaram
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000628:therapy*; D016229:Amyloid beta-Peptides; D006801:Humans; D010330:Patents as Topic; D010446:Peptide Fragments; D010455:Peptides / Q000627:therapeutic use*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; D010455:Peptides