title: Hepatitis C virus inhibitory hydrolysable tannins from the fruits of Terminalia chebula.
abstract: Two new hydrolysable tannins, chebumeinin A (1) and chebumeinin B (2), together with eight known related compounds (3-10), were isolated from the fruits of Terminalia chebula. The new compounds were structurally determined by analysis of their spectroscopic data and the known compounds characterized by comparing their spectroscopic data with literature values. All isolates were evaluated by an HCV protease inhibition assay, and some compounds were found to be potently active.
authors.affiliation: College of Life Sciences, Inner Mongolia University, 235 West University Road, Huhhot 010021, PR China; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The University of Lagos, CMUL/LUTH campus, PMB12003 Idiaraba-Surulere, Lagos, Nigeria.
authors.forename: Olusegun S
authors.initials: OS
authors.lastname: Ajala
authors.affiliation: College of Life Sciences, Inner Mongolia University, 235 West University Road, Huhhot 010021, PR China.
authors.forename: Azzaya
authors.initials: A
authors.lastname: Jukov
authors.affiliation: College of Life Sciences, Inner Mongolia University, 235 West University Road, Huhhot 010021, PR China. Electronic address: cmma@imu.edu.cn.
authors.forename: Chao-Mei
authors.initials: CM
authors.lastname: Ma
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D029766:Terminalia / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D047348:Hydrolyzable Tannins; C000597658:chebumeinin A; C000597659:chebumeinin B
keywords: 5-O-galloylshikimic acid (PubChem CID: 460899); Chebulagic acid (PubChem CID: 442674); Chebulic acid (PubChem CID: 71308174); Chebumeinin; Chebumeinin A, chebumeinin B Casuarinin (PubChem CID: 157395); Corilagin (PubChem CID: 73568); Ellagic acid (PubChem CID: 5281855); Gallic acid (PubChem CID: 370); HCV protease inhibition; Hydrolysable tannins; Pentagalloyl glucose (PubChem CID: 65238); Small molecule HCV-protease inhibitors; Terminalia chebula