title: Modulation of interhemispheric functional coordination in electroconvulsive therapy for depression.
abstract: Considerable evidence suggests that depression is related to interhemispheric functional coordination deficits. For depression, electroconvulsive therapy (ECT) is the most rapid and effective therapy, but its underlying mechanism remains unknown. The aim of this study was to explore the impact of ECT on the interhemispheric functional coordination in depression patients. We used resting-state functional magnetic resonance imaging to observe the change of interhemispheric functional coordination with the method of voxel-mirrored homotopic connectivity (VMHC) in 11 depressed patients before and after ECT, compared with 15 healthy controls. The results showed that, compared with depression patients before ECT, VMHC was significantly increased in superior frontal gyri (BA 8), middle frontal gyri (two clusters: BA 8/9 and BA 10) and angular gyri (BA 39) in depression patients after ECT. Compared with healthy controls, VMHC in those areas was significantly lower in the middle frontal gyri (BA 8/9) and angular gyri (BA 39) in depression patients before ECT, but no significant difference was observed in the superior frontal gyri (BA 8) and middle frontal gyri (BA 10). There was no significant correlation between the changes of Hamilton Depression Rating Scale scores and changed VMHC values in those four areas in depression patients. The results suggest that ECT selectively modulated interhemispheric functional coordination in depression patients. Such may play an important mechanistic role in the treatment of depression, and may afford a useful avenue for optimizing treatment.
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.affiliation: Anhui Mental Health Center, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Anhui Mental Health Center, Hefei, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: P
authors.initials: P
authors.lastname: Hu
authors.affiliation: Anhui Mental Health Center, Hefei, China.
authors.forename: X
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
authors.forename: K
authors.initials: K
authors.lastname: Wang
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D003866:Depressive Disorder / Q000628:therapy; D004565:Electroconvulsive Therapy / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged