title: A cytotoxic and cytostatic gold(III) corrole.
abstract: We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.
authors.affiliation: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA. hbgray@caltech.edu.
authors.forename: Ruijie D
authors.initials: RD
authors.lastname: Teo
authors.forename: Harry B
authors.initials: HB
authors.lastname: Gray
authors.forename: Punnajit
authors.initials: P
authors.lastname: Lim
authors.forename: John
authors.initials: J
authors.lastname: Termini
authors.forename: Elena
authors.initials: E
authors.lastname: Domeshek
authors.forename: Zeev
authors.initials: Z
authors.lastname: Gross
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D054697:Cytostatic Agents / Q000737:chemistry / Q000494:pharmacology; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D005708:Gallium / Q000737:chemistry / Q000494:pharmacology; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D050607:Organogold Compounds / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D054697:Cytostatic Agents; D003603:Cytotoxins; D050607:Organogold Compounds; D011166:Porphyrins; D012709:Serum Albumin; C431863:corrole; D006046:Gold; D005708:Gallium