title: Association between Glycosylated Haemoglobin Level and Contrast-Induced Acute Kidney Injury in Patients with Type 2 Diabetes Mellitus.
abstract: BACKGROUND
  There are several reports suggesting that admission hyperglycaemia increases the risk of contrast-induced acute kidney injury (CI-AKI). However, it is not clear whether there has been an association between long-standing poor glycaemic control and the incidence of CI-AKI. The purpose of this study was to examine the impact of poor glycaemic control or elevated glycosylated haemoglobin (HbA1c) on the incidence of CI-AKI in patients with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  The present study prospectively enrolled 133 patients with T2DM undergoing elective coronary angiography (CAG) and/or intervention. All patients had an estimated glomerular filtration rate (eGFR) of ≥60 ml/min/1.73 m(2). Patients were divided into two groups: those with an optimal HbA1c (<7%) and those with an elevated HbA1c (≥7%). All had similar baseline characteristics and were hydrated appropriately. The outcome was assessed by the incidence of CI-AKI.
  
  
  RESULTS
  CI-AKI occurred in 2 of 41 patients (4.9%) with optimal HbA1c levels and 5 of 92 patients (5.4%) with elevated HbA1c levels (p = 0.89). The cutoff point of HbA1c was set at 6.5%, but no statistically significant difference between the two groups was observed [1 of 24 patients (4.1%) vs. 6 of 109 patients (5.5%), p = 0.79]. However, despite a high variability in the incidence of CI-AKI, there was no statistically significant difference between the two groups when varying CI-AKI definitions were considered.
  
  
  CONCLUSIONS
  An elevated HbA1c level is not associated with a higher incidence of CI-AKI compared to optimal HbA1c levels in patients with T2DM (patients with an eGFR of ≥60 ml/min/1.73 m(2)) undergoing CAG and/or intervention.
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Sukru
authors.initials: S
authors.lastname: Akyuz
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Kemaloglu Oz
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Altay
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Karaca
authors.affiliation: Department of Cardiology, Diyarbakır Training and Research Hospital, Diyarbakır, Ordu, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Yaylak
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Gungor
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Selcuk
authors.initials: S
authors.lastname: Yazici
authors.affiliation: Department of Cardiology, Fatsa State Hospital, Ordu, Turkey.
authors.forename: Guney
authors.initials: G
authors.lastname: Erdogan
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.affiliation: Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Ordu, Turkey.
authors.forename: Hulya
authors.initials: H
authors.lastname: Kasikcioglu
keywords: Acute kidney injury; Contrast media; Coronary angiography; Percutaneous coronary intervention; Type 2 diabetes mellitus