title: Survival in patients with limited-stage peripheral T-cell lymphomas.
abstract: The natural history of limited-stage peripheral T-cell lymphoma (PTCL) remains poorly defined. Therefore, we examined outcomes in patients with the most common PTCL subtypes (PTCL, not otherwise specified [PTCL, NOS], angioimmunoblastic T-cell lymphoma [AITL], anaplastic large cell lymphoma [ALCL]) and limited-stage disease. In this retrospective, multicenter study, 75 patients with limited-stage disease were identified. The median event-free survival (EFS) and overall survival (OS) observed were 2.1 and 6.5 years, respectively. In a landmark analysis excluding patients with primary refractory disease, no significant benefit was observed for patients undergoing consolidative radiation therapy. With the exception of patients undergoing salvage hematopoietic stem cell transplant, survival following disease relapse or progression was poor, thus highlighting the need for improved therapeutic strategies.
authors.affiliation: Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan , Ann Arbor, MI , USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Briski
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Feldman
authors.forename: Nathaniel G
authors.initials: NG
authors.lastname: Bailey
authors.forename: Megan S
authors.initials: MS
authors.lastname: Lim
authors.forename: Kay
authors.initials: K
authors.lastname: Ristow
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Habermann
authors.forename: William R
authors.initials: WR
authors.lastname: Macon
authors.forename: David J
authors.initials: DJ
authors.lastname: Inwards
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Colgan
authors.forename: Grzegorz S
authors.initials: GS
authors.lastname: Nowakowski
authors.forename: Mark S
authors.initials: MS
authors.lastname: Kaminski
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Witzig
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Ansell
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Wilcox
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: Peripheral T-cell lymphoma; prognosis; radiation