title: [Tissue regeneration strategies: cells, biochemical inductors, bionanomaterials and bioconstructions. Clinical and surgical achievements].
abstract: Regenerative medicine is a medical multidisciplinary area with the aim of morphologic and functional restoration of tissues or organs in order to re-establish normal function. The main bases of regenerative medicine are the use of autologous stem or progenitor cells and the ex vivo construction of physical-mechanical tissue structuring organization, which with stem cells may form bioartificial organs. Another eventual strategy is in vivo stem or progenitor cell stimulation for proliferation. Tissue engineering entirely combines the use of cells, biochemical and physicochemical factors, nanomaterials and bioengineering methods to improve or replace biological functions of tissues and organs. The progressive understanding of the proliferation and differentiation of the process of stem cells and their in vitro manipulation has been the launching platform for the field of regenerative medicine. In this review we describe the main strategies used for regenerative medicine in tissue regeneration along with the main obtained clinicalsurgical benefits.
authors.affiliation: Departamento de Atención a la Salud, Universidad Autónoma Metropolitana, Unidad Xochimilco, México DF, Mexico. vvaldespinog@yahoo.com.mx.
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Valdespino-Gómez
authors.affiliation: Instituto de Ecología, Universidad Nacional Autónoma de México, México DF, Mexico.
authors.forename: Patricia Margarita
authors.initials: PM
authors.lastname: Valdespino-Castillo
authors.affiliation: Unidad Médica de Atención Ambulatoria, Instituto Mexicano del Seguro Social, Campeche, Campeche, México.
authors.forename: Víctor Edmundo
authors.initials: VE
authors.lastname: Valdespino-Castillo
mesh_terms: D062088:Acellular Dermis; D021522:Bioartificial Organs; D001688:Biological Products / Q000627:therapeutic use; D002454:Cell Differentiation; D005109:Extracellular Matrix / Q000737:chemistry; D005544:Forecasting; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D049329:Nanostructures; D039904:Pluripotent Stem Cells / Q000637:transplantation; D019736:Prostheses and Implants; D044968:Regenerative Medicine / Q000379:methods* / Q000639:trends; D013526:Surgical Mesh; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends
chemical_list: D001688:Biological Products; D036341:Intercellular Signaling Peptides and Proteins
keywords: Regenerative medicine; clinical benefit; estrategias; logros clínicoquirúrgicos; medicina regenerativa; strategies