title: High order intra-strand partial symmetry increases with organismal complexity in animal evolution.
abstract: For sufficiently long genomic sequence, the frequency of any short nucleotide fragment on one strand is approximately equal to the frequency of its reverse complement on the same strand. Despite being studied over two decades, the precise mechanism involved has not yet been made clear. In this study, we calculated the high order intra-strand partial symmetry (IPS) for 14 animal species by using a fixed sliding window method to scan each genome sequence. The study showed that the IPS was positive associated with organismal complexity measured by the number of distinct cell types. The results indicated that the IPS might be resulted from the increasing of functional non-coding DNAs, and plays an important role in the evolution process of complex body plans.
authors.affiliation: State Key Lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
authors.forename: Shengqin
authors.initials: S
authors.lastname: Wang
authors.affiliation: State Key Lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tu
authors.affiliation: National Institute of Drug Dependence, Peking University, Beijing 100191, China.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Jia
authors.affiliation: 1] State Key Lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China [2] Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100781, China.
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Lu
mesh_terms: D000818:Animals; D001482:Base Composition / Q000235:genetics; D001483:Base Sequence; D005075:Biological Evolution; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D017422:Sequence Analysis, DNA