title: Challenges and priorities for research: a report from the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH) Working Group on thrombosis in pediatric cardiology and congenital heart disease.
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.). brian.mccrindle@sickkids.ca.
authors.forename: Brian W
authors.initials: BW
authors.lastname: McCrindle
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Li
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Cedric
authors.initials: C
authors.lastname: Manlhiot
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: James S
authors.initials: JS
authors.lastname: Tweddell
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Therese M
authors.initials: TM
authors.lastname: Giglia
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: M Patricia
authors.initials: MP
authors.lastname: Massicotte
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Paul
authors.initials: P
authors.lastname: Monagle
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Rajesh
authors.initials: R
authors.lastname: Krishnamurthy
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Mahaffey
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Alan D
authors.initials: AD
authors.lastname: Michelson
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Nicole
authors.initials: N
authors.lastname: Verdun
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Almond
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Jane W
authors.initials: JW
authors.lastname: Newburger
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Leonardo R
authors.initials: LR
authors.lastname: Brandão
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Charles T
authors.initials: CT
authors.lastname: Esmon
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Marilyn J
authors.initials: MJ
authors.lastname: Manco-Johnson
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Rebecca
authors.initials: R
authors.lastname: Ichord
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Ortel
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Chan
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Ron
authors.initials: R
authors.lastname: Portman
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Martin
authors.initials: M
authors.lastname: Rose
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: John
authors.initials: J
authors.lastname: Strony
authors.affiliation: From the Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada (B.W.M., C.M., L.R.B.); Duke University Medical Center, Duke University, Durham, NC (J.S.L., T.L.O.); Children's Hospital of Wisconsin, Medical College of Wisconsin, Milwaukee, WI (J.S.T.); Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (T.M.G., R.I.); Stollery Children's Hospital, University of Alberta, Edmonton, Alberta, Canada (M.P.M.); Royal Children's Hospital, Murdoch Children's Research Institute, University of Melbourne, Melbourne, Australia (P.M.); Texas Children's Hospital, Baylor College of Medicine, Houston, TX (R.K.); Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.); Boston Children's Hospital, Harvard Medical School, Boston, MA (A.D.M., C.S.A., J.W.N.); Children's National Medical Center, George Washington University, Washington, DC (N.V.); Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK (C.T.E.); Children's Hospital of Colorado, University of Colorado, Aurora, CO (M.J.M-.J.); McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada (A.K.C.); Bristol-Myers Squibb, Princeton, NJ (R.P.); Division of Cardiovascular and Renal Protocol, Food & Drug Administration, Silver Spring, MD (M.R.); Merck, Whitehouse Station, NJ (J.S.); and Division of Cardiovascular Sciences, NHLBI/NIH, Bethesda, MD (J.R.K.).
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Kaltman
mesh_terms: D002309:Cardiology; D002648:Child; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D006331:Heart Diseases / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D006801:Humans; D054555:National Heart, Lung, and Blood Institute (U.S.); D010372:Pediatrics; D012106:Research; D013927:Thrombosis / Q000175:diagnosis / Q000601:surgery / Q000628:therapy*; D014481:United States
keywords: antithrombotic agents; cardiology; pediatrics; thrombosis