title: The potential evasion of immune surveillance in mucosa associated lymphoid tissue lymphoma by DcR2-mediated up-regulation of nuclear factor-κB.
abstract: This study investigated expression profiles of tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) pathway components and mechanisms underlying TRAIL-induced apoptosis in mucosa associated lymphoid tissue (MALT) lymphoma. Genetic aberrations including translocations and trisomies were assessed by reverse transcription polymerase chain reaction and fluorescence in situ hybridization. Expression of TRAIL, death receptors 4 and 5, decoy receptors 1 and 2, and FADD-like interleukin-1β-converting enzyme (FLICE) inhibitory protein was analyzed by immunohistochemistry. All 32 patients under study showed some alterations in TRAIL pathway mainly involving loss of death receptors (37.5%), gain of decoy receptors (3.1%) or both (59.4%). Decoy receptor 2 (DcR2) was highly expressed in patients with normal cytogenetic status as compared to those with cytogenetic aberrations (p = 0.005). Moreover, DcR2 expression correlated significantly with nuclear factor-κB (NF-κB) expression (R = 0.372, p = 0.047). High expression of DcR2 in patients with normal cytogenetic status and its significant correlation with NF-κB expression provides a potential clue to evasion of immune surveillance in cytogenetically normal MALT lymphomas.
authors.affiliation: Division of Oncology, Department of Medicine I, Medical University of Vienna , Vienna , Austria.
authors.forename: Mariam
authors.initials: M
authors.lastname: Anees
authors.forename: Peter
authors.initials: P
authors.lastname: Horak
authors.forename: Ana-Iris
authors.initials: AI
authors.lastname: Schiefer
authors.forename: Petr
authors.initials: P
authors.lastname: Vaňhara
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Gazzar
authors.forename: Paul
authors.initials: P
authors.lastname: Perco
authors.forename: Barbara
authors.initials: B
authors.lastname: Kiesewetter
authors.forename: Leonhard
authors.initials: L
authors.lastname: Müllauer
authors.forename: Berthold
authors.initials: B
authors.lastname: Streubel
authors.forename: Markus
authors.initials: M
authors.lastname: Raderer
authors.forename: Michael
authors.initials: M
authors.lastname: Krainer
mesh_terms: D000328:Adult; D000368:Aged; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000235:genetics / Q000378:metabolism; D002869:Chromosome Aberrations; D005260:Female; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D060787:Neoplasm Grading; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000235:genetics / Q000378:metabolism; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism; D019139:Tumor Escape / Q000235:genetics / Q000276:immunology*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D016328:NF-kappa B; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D053221:TNF-Related Apoptosis-Inducing Ligand; C451501:TNFRSF10D protein, human; D053319:Tumor Necrosis Factor Decoy Receptors
keywords: DcR2; MALT lymphoma; NF-κB; TRAIL