title: Giant solitary gastric Peutz-Jeghers polyp mimicking a malignant gastric tumor: the largest described in literature.
abstract: A solitary Peutz-Jeghers polyp is defined as a unique polyp occurring without associated mucocutaneous pigmentation or a family history of Peutz-Jeghers syndrome. Gastric solitary localization is a rare event, with only eight reported cases to date. We report herein the case of a 43-year old woman who presented with upper gastrointestinal bleeding, severe anemia, weight loss and asthenia. Endoscopy revealed a giant polypoid tumor with signs of neoplastic invasion of the cardia, with pathological aspect suggesting a Peutz-Jeghers hamartomatous polyp. Computed tomography suggested a malignant gastric tumor and a total gastrectomy was performed. The pathological specimen showed a giant 150/70/50 mm polypoid tumor and immunochemistry established the final diagnostic of a Peutz-Jegers type polyp. This is the largest solitary Peutz-Jeghers gastric polyp reported until now, and the second one mimicking a gastric malignancy with lymph node metastasis.
authors.affiliation: Regional Institute of Oncology, 2nd Department of Oncologic Surgery; Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Sorinel
authors.initials: S
authors.lastname: Lunca
authors.affiliation: Regional Institute of Oncology, 2nd Department of Oncologic Surgery; Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania. porumbvlad@ymail.com.
authors.forename: Vlad
authors.initials: V
authors.lastname: Porumb
authors.affiliation: Regional Institute of Oncology, 2nd Department of Oncologic Surgery, Iasi, Romania.
authors.forename: Natalia
authors.initials: N
authors.lastname: Velenciuc
authors.affiliation: Regional Institute of Oncology, Department of Pathology, Iasi, Romania.
authors.forename: Dan
authors.initials: D
authors.lastname: Ferariu
authors.affiliation: Regional Institute of Oncology, 2nd Department of Oncologic Surgery; Gr. T. Popa University of Medicine and Pharmacy, Iasi, Romania.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Dimofte
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D007150:Immunohistochemistry; D010580:Peutz-Jeghers Syndrome / Q000473:pathology* / Q000601:surgery; D011127:Polyps / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D013272:Stomach Diseases / Q000473:pathology* / Q000601:surgery; D013274:Stomach Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed