title: The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice.
abstract: Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.
authors.affiliation: a Key Laboratory of Functional Food , Ministry of Agriculture, Sericultural and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences , Guangzhou , P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Mingwei
authors.initials: M
authors.lastname: Zhang
authors.forename: Ruifen
authors.initials: R
authors.lastname: Zhang
authors.forename: Mira
authors.initials: M
authors.lastname: Lee
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Jingang
authors.initials: J
authors.lastname: Hou
authors.forename: Chang-Keun
authors.initials: CK
authors.lastname: Sung
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D018891:Dentate Gyrus / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D055495:Neurogenesis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D065852:Spatial Memory / Q000187:drug effects*
chemical_list: D010936:Plant Extracts; C555710:chong-myung-tang
keywords: Chong-Myung-Tang; cell proliferation; cell survival; dentate gyrus; spatial memory