title: Molecular biomarkers in idiopathic pulmonary fibrosis.
abstract: Molecular biomarkers are highly desired in idiopathic pulmonary fibrosis (IPF), where they hold the potential to elucidate underlying disease mechanisms, accelerated drug development, and advance clinical management. Currently, there are no molecular biomarkers in widespread clinical use for IPF, and the search for potential markers remains in its infancy. Proposed core mechanisms in the pathogenesis of IPF for which candidate markers have been offered include alveolar epithelial cell dysfunction, immune dysregulation, and fibrogenesis. Useful markers reflect important pathological pathways, are practically and accurately measured, have undergone extensive validation, and are an improvement upon the current approach for their intended use. The successful development of useful molecular biomarkers is a central challenge for the future of translational research in IPF and will require collaborative efforts among those parties invested in advancing the care of patients with IPF.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California; and.
authors.forename: Brett
authors.initials: B
authors.lastname: Ley
authors.affiliation: Department of Medicine, National Jewish Health and the University of Colorado, Denver, Colorado.
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Brown
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California; and hal.collard@ucsf.edu.
authors.forename: Harold R
authors.initials: HR
authors.lastname: Collard
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D001798:Blood Proteins / Q000235:genetics / Q000378:metabolism; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000175:diagnosis* / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D007113:Immunity, Innate; D008168:Lung / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D055257:Mucin-5B / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D037661:Pulmonary Surfactant-Associated Proteins / Q000235:genetics / Q000378:metabolism; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology; D019098:Telomerase / Q000235:genetics / Q000378:metabolism; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; C524578:MUC5B protein, human; D055257:Mucin-5B; D037661:Pulmonary Surfactant-Associated Proteins; C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3; C509186:TERT protein, human; D019098:Telomerase
keywords: biomarker; diagnosis; prediction; pulmonary fibrosis