title: Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?
abstract: Advanced glycation end products (AGEs) are a diverse group of compounds produced when reducing sugars react with proteins or other compounds to form glycosylated molecules. AGEs may form endogenously, and glycation of molecules may negatively affect their function. AGEs may also be consumed in food form with dietary AGEs reported to be particularly high in foods treated with high heat: baked, broiled, grilled, and fried foods. Whether dietary AGEs are absorbed in significant quantities and whether they are harmful if absorbed is a question under current debate. The American Diabetes Association makes no recommendation regarding avoidance of these foods, but many researchers are concerned that they may be pro-inflammatory and way worsen cardiac function, kidney function, diabetes and its complications and may even contribute to obesity.
authors.affiliation: a Texas Woman's University, Nutrition and Food Sciences , Denton , Texas , USA.
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: Davis
authors.affiliation: a Texas Woman's University, Nutrition and Food Sciences , Denton , Texas , USA.
authors.forename: Chandan
authors.initials: C
authors.lastname: Prasad
authors.affiliation: a Texas Woman's University, Nutrition and Food Sciences , Denton , Texas , USA.
authors.forename: Parakat
authors.initials: P
authors.lastname: Vijayagopal
authors.affiliation: a Texas Woman's University, Nutrition and Food Sciences , Denton , Texas , USA.
authors.forename: Shanil
authors.initials: S
authors.lastname: Juma
authors.affiliation: a Texas Woman's University, Nutrition and Food Sciences , Denton , Texas , USA.
authors.forename: Victorine
authors.initials: V
authors.lastname: Imrhan
mesh_terms: D002908:Chronic Disease; D017127:Glycation End Products, Advanced / Q000633:toxicity*; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D008659:Metabolic Diseases / Q000139:chemically induced*
chemical_list: D017127:Glycation End Products, Advanced
keywords: Advanced glycation end products; maillard reactant products; glycotoxins; inflammation; obesity; diabetes; cardiovascular disease; kidney disease