title: Prevalence of Helicobacter pylori infection and its relation with body mass index in a Chinese population.
abstract: BACKGROUND
  Helicobacter pylori infection is highly prevalent worldwide. The association between obesity and H. pylori infection is controversial in the literature. This study aims to investigate the prevalence of H. pylori infection and its relation with body mass index (BMI) in a Chinese population.
  
  
  METHODS
  A cross-sectional study was performed among adults who underwent health checkups at the First Affiliated Hospital, College of Medicine, Zhejiang University in 2013. The prevalence of H. pylori infection was examined by (13)C urea breath tests, and the association between prevalence of H. pylori infection and BMI was analyzed.
  
  
  RESULTS
  Of the 8820 participants enrolled, 3859 (43.8%) were positive for H. pylori infection. H. pylori-positive participants had a more unfavorable metabolic profile than H. pylori-negative participants. Overweight/obese participants showed a higher prevalence of H. pylori infection than that of lean participants, and a positive linear correlation between BMI and prevalence of H. pylori infection was observed. Both unadjusted and adjusted analysis revealed that BMI was significantly associated with risk factors of H. pylori infection.
  
  
  CONCLUSIONS
  Our results showed that BMI was significantly and positively associated with H. pylori infection, and a high BMI was associated with an increased risk of the infection.
authors.affiliation: Department of Gastroenterology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Cancer Cluster, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, USA; Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Chengfu
authors.initials: C
authors.lastname: Xu
authors.forename: Ming
authors.initials: M
authors.lastname: Yan
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jungsoo
authors.initials: J
authors.lastname: Joo
authors.forename: Xingyong
authors.initials: X
authors.lastname: Wan
authors.forename: Chaohui
authors.initials: C
authors.lastname: Yu
authors.forename: Qunyan
authors.initials: Q
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Shen
authors.forename: Peng
authors.initials: P
authors.lastname: Chen
authors.forename: Youming
authors.initials: Y
authors.lastname: Li
authors.forename: William G
authors.initials: WG
authors.lastname: Coleman
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001944:Breath Tests; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
keywords: Helicobacter pylori; body mass index; prevalence