title: [Hormonal deficiencies in the elderly: is there a role for replacement therapy?].
abstract: Biological aging is characterized by a progressive loss of the secretion of various hormones, a phenomenon that leads some physicians to propose an anti-aging hormonal therapy. It is mandatory to differentiate: 1) the physiological functional loss, which is a natural phenomenon without clear deleterious consequences on health and should not be compensated by the administration of hormones only to restore plasma levels similar to those measured in young people and 2) a pathological defect that deserves a replacement therapy to correct the endocrine deficiency and improve the health status of older individuals. This article considers the deficiencies in insulin, thyroid hormones, growth hormone, dehydroepiandrosterone (DHEA) and testosterone. For each hormone, a benefit/risk ratio of a so-called replacement therapy will be analyzed.
authors.forename: Valentina
authors.initials: V
authors.lastname: Racaru-Honciuc
authors.forename: Daniela
authors.initials: D
authors.lastname: Betea
authors.forename: André J
authors.initials: AJ
authors.lastname: Scheen
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000172:deficiency; D000368:Aged; D000375:Aging / Q000378:metabolism*; D000728:Androgens / Q000008:administration & dosage / Q000172:deficiency; D003687:Dehydroepiandrosterone / Q000008:administration & dosage / Q000172:deficiency; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000819:agonists; D013006:Growth Hormone / Q000172:deficiency / Q000627:therapeutic use; D006304:Health Status; D020249:Hormone Replacement Therapy / Q000009:adverse effects / Q000379:methods; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D013739:Testosterone / Q000008:administration & dosage / Q000172:deficiency; D013963:Thyroid Hormones / Q000008:administration & dosage / Q000172:deficiency
chemical_list: D000276:Adjuvants, Immunologic; D000728:Androgens; D007004:Hypoglycemic Agents; D007328:Insulin; D013963:Thyroid Hormones; D013739:Testosterone; D003687:Dehydroepiandrosterone; D052216:Glucagon-Like Peptide 1; D013006:Growth Hormone; D008687:Metformin