title: [Role of parathyroid hormone-like hormone during embryonic development].
abstract: Parathyroid hormone-like hormone (PTHLH), also known as parathyroid hormone-related protein (PTHrP), was first identified as a parathyroid hormone (PTH)-like factor responsible for humoral hypercalcaemia in malignancies. Subsequent studies demonstrated that PTHLH has multiple physiological functions in many fetal and adult tissues, including the regulation of morphogenesis, cell proliferation and differentiation, and transplacental calcium transport. This review focuses on the biological characteristics of PTHLH and its function during embryonic development. The signaling pathway and potential mechanism involved are further discussed.
authors.affiliation: College of Animal Science and Technology, Guangxi University, Nanning 530004, China; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.affiliation: College of Animal Science and Technology, Guangxi University, Nanning 530004, China.
authors.forename: Shengsheng
authors.initials: S
authors.lastname: Lu
authors.affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Han
mesh_terms: D000818:Animals; D047108:Embryonic Development; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008297:Male; D044162:Parathyroid Hormone-Related Protein / Q000235:genetics / Q000378:metabolism*; D011247:Pregnancy; D015398:Signal Transduction
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein