title: [Role of central venous pressure, global end diastolic volume index and extravascular lung water index in evaluating fluid resuscitation in patients with septic shock].
abstract: OBJECTIVE
  To explore the role of central venous pressure (CVP), global end diastolic volume index (GEDI) and extravascular lung water index (ELWI) monitoring in patients with septic shock during fluid resuscitation by pulse induced continuous cardiac output (PiCCO) test.
  
  
  METHODS
  Forty-six patients with severe sepsis and septic shock were enrolled in this study. Hemodynamic monitoring was performed during fluid resuscitation and the data including CVP, GEDI and ELWI were collected to analyze their relationship and the clinical values.
  
  
  RESULTS
  In patients with septic shock, CVP showed a weak linear correlation with GEDI during fluid resuscitation (r=0.137, P=0.009). In the subgroups stratified with CVP cut-off values of 8 mmHg and 12 mmHg, the correlation coefficient between CVP and GEDI was 0.149 (P=0.029) in CVP<8 mmHg group, 0.075 (P=0.462) in 8 mmHg ≤ CVP ≤ 12 mmHg group, and 0.049 (P=0.726) in CVP>12 mmHg group. In the total of 367 data groups obtained, CVP showed no linear correlation with ELWI (r=0.040, P=0.445). In the CVP subgroups, CVP and ELWI were weakly correlated in CVP<8 mmHg group (r=0.221, P=0.001), but they showed no correlations in 8 mmH g≤ CVP ≤ 12 mmHg and CVP>12 mmHg groups (r=-0.047, P=0.646; r=0.042, P=0.765).
  
  
  CONCLUSIONS
  There is no significant linear correlation between CVP and GEDI or between CVP and ELWI in patients with septic shock. CVP can not reflect the circulatory blood volume or the degree of pulmonary edema.
authors.affiliation: 1Department of Critical Care, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China; 2Lecong Hospital of Shunde Distinct, Foshan 528315, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Qikang
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhongran
authors.initials: Z
authors.lastname: Cen
authors.forename: Ying
authors.initials: Y
authors.lastname: Tang
authors.forename: Liang
authors.initials: L
authors.lastname: Cai
authors.forename: Zhanguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Chang
mesh_terms: D001810:Blood Volume; D002302:Cardiac Output; D002496:Central Venous Pressure; D015633:Extravascular Lung Water; D005440:Fluid Therapy; D006801:Humans; D011654:Pulmonary Edema; D012151:Resuscitation; D012772:Shock, Septic / Q000628:therapy*