title: Preliminary dosimetric evaluation of (166)Ho-TTHMP for human based on biodistribution data in rats.
abstract: In this work, the absorbed dose to each organ of human for (166)Ho-TTHMP was evaluated based on biodistribution studies in rats by a RADAR method and was compared with (166)Ho-DOTMP as the only clinically used Ho-166 bone marrow ablative agent. The highest absorbed dose for this complex is observed in red marrow with 0.922mGy/MBq. The results show that (166)Ho-TTHMP has considerable characteristics compared to (166)Ho-DOTMP and can be a good candidate for bone marrow ablation in patients with multiple myeloma.
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Yousefnia
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran. Electronic address: szolghadri@aeoi.org.ir.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Zolghadri
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran.
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Jalilian
authors.affiliation: School of Physics, Damghan University, Damghan 36716-41167, Iran.
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Tajik
authors.affiliation: Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghannadi-Maragheh
mesh_terms: D065638:Absorption, Radiation; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D003198:Computer Simulation; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006695:Holmium / Q000493:pharmacokinetics*; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009928:Organ Specificity; D010865:Pilot Projects; D011829:Radiation Dosage; D011868:Radioisotopes / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D013045:Species Specificity; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
chemical_list: D011868:Radioisotopes; D019275:Radiopharmaceuticals; C026059:triethylenetetraminehexaacetic acid; D004492:Edetic Acid; D006695:Holmium
keywords: (166)Ho-TTHMP; Bone marrow ablation; Internal dosimetry; RADAR