title: Comparison of British Thoracic Society and American Thoracic Society reintroduction guidelines for anti-tuberculous therapy induced liver injury.
abstract: OBJECTIVE
  To compare the efficacy of British Thoracic Society and American Thoracic Society guidelines for reintroduction of anti-tuberculous therapy after drug-induced liver injury, and to assess the ease of administration of each guideline on a scale of 1-10.
  
  
  METHODS
  The randomised prospective interventional study was conducted at the Department of Medicine and Pulmonology, Dow University of Health Sciences, Karachi, from December 2011 to November 2013. Patients with anti-tuberculous therapy drug-induced liver injury were selected. Hepatotoxic anti-tuberculous therapy was stopped and modified anti-tuberculous therapy was started. Patients were followed weekly till clinical and biochemical parameters got stabilised. After stabilisation, the patients were randomised to one of the two groups to receive re-introduction of anti-tuberculous therapy under the guidelines of British Thoracic Society (Group I) or those of American Thoracic Society (Group II). Means of the groups were analysed by Student's t test and proportions were compared by chi-square test. Multivariate analysis was done for age, body mass index and serum albumin for recurrence of drug-induced liver injury after the re-introduction. P value < 0.05 was taken as significant.
  
  
  RESULTS
  Of the total 325 patients, 163 (50.15%) were in Group I, while 162 (49.84%) were in Group II. The frequency of recurrence of drug-induced liver injury in Group I was 16 (9.8%) and in Group II it was 18 (11.1%).There was no statistically significant difference between the two groups (p < 0.7). Age was positively related with drug-induced liver injury, while body mass index and serum albumin were negatively associated.
  
  
  CONCLUSIONS
  There was no significant difference between the two major guidelines though the American Thoracic Society guideline was easier to follow.
authors.forename: Bader Faiyaz
authors.initials: BF
authors.lastname: Zuberi
authors.forename: Faisal Faiyaz
authors.initials: FF
authors.lastname: Zuberi
authors.forename: Nimrah
authors.initials: N
authors.lastname: Bader
authors.forename: Haris
authors.initials: H
authors.lastname: Alvi
authors.forename: Javeria
authors.initials: J
authors.lastname: Salahuddin
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D012955:Societies, Medical; D006113:United Kingdom; D014481:United States
chemical_list: D000995:Antitubercular Agents