title: Association of -174G/C interleukin/6 gene polymorphism with the risk of chronic lymphocytic, chronic myelogenous and acute myelogenous leukemias in Turkish patients.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the relationship between -174G/C interleukin-6 (IL-6) gene promoter polymorphism and susceptibility to chronic lymphocytic (CLL), chronic myelogenous (CML) and acute myelogenous leukemia (AML) in Turkish patients.
  
  
  METHODS
  The frequencies of -174G/C polymorphism were studied in 23 unrelated CLL, 25 CML and 17 AML patients and 30 healthy individuals. Single nucleotide polymorphisms (SNPs) were genotyped by the PCR-RFLP method.
  
  
  RESULTS
  A higher prevalence of the C allele was found in CLL, CML and AML patients. However, there were no statistically significant differences regarding either the genotype or the allelic frequencies of the -174G/C polymorphism between CLL, CML and AML cases.
  
  
  CONCLUSIONS
  These results indicate that C allele is associated with risk of CLL, CML and AML susceptibility in Turkish patients.
authors.affiliation: Middle East Technical University, Central Laboratory, Molecular Biology and Biotechnology R&D, Ankara, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Mutlu
authors.forename: Serap
authors.initials: S
authors.lastname: Yalcin
authors.forename: Pinar
authors.initials: P
authors.lastname: Elci
authors.forename: Murat
authors.initials: M
authors.lastname: Yildirim
authors.forename: A Turker
authors.initials: AT
authors.lastname: Cetin
authors.forename: Ferit
authors.initials: F
authors.lastname: Avcu
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics*; D007951:Leukemia, Myeloid / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D014421:Turkey
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6