title: CEBPA-regulated lncRNAs, new players in the study of acute myeloid leukemia.
abstract: CCAAT/enhancer-binding protein-α (CEBPA) is a critical regulator of myeloid differentiation. Disruption of CEBPA function contributes to the development of acute myeloid leukemia (AML). CEBPA regulates a large number of protein coding genes of which several were shown to contribute to CEBPA function. In this study, we expand the analysis of CEBPA transcriptional targets to the newly identified class of long non-coding RNAs. We show that lncRNAs are a main component of the transcriptional program driven by C/EBPα and that many of these are also induced during granulocytic differentiation of AML cell lines supporting their relevance in proliferation arrest and differentiation.
authors.forename: James M
authors.initials: JM
authors.lastname: Hughes
authors.forename: Beatrice
authors.initials: B
authors.lastname: Salvatori
authors.forename: Federico M
authors.initials: FM
authors.lastname: Giorgi
authors.forename: Irene
authors.initials: I
authors.lastname: Bozzoni
authors.affiliation: Department of Biology and Biotechnology C, Darwin, Sapienza University of Rome, Rome, 00185, Italy. alessandro.fatica@uniroma1.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Fatica
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D045744:Cell Line, Tumor; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D062085:RNA, Long Noncoding