title: Epithelial plasticity in prostate cancer: principles and clinical perspectives.
abstract: Over the past decade, the capacity of cancer cells to oscillate between epithelial and mesenchymal phenotypes, termed epithelial plasticity (EP), has been demonstrated to play a critical role in metastasis. This phenomenon may be particularly important for prostate cancer (PC) progression, since recent studies have revealed interplay between EP and signaling by the androgen receptor (AR) oncoprotein. Moreover, EP appears to play a role in dictating the response to therapies for metastatic PC. This review will evaluate preclinical and clinical evidence for the relevance of EP in PC progression and consider the potential of targeting and measuring EP as a means to treat and manage lethal forms of the disease.
authors.affiliation: Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, The University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, The University of Adelaide, South Australia, Australia; Discipline of Medicine, The University of Adelaide, South Australia, Australia.
authors.forename: Rajdeep
authors.initials: R
authors.lastname: Das
authors.affiliation: Discipline of Medicine, The University of Adelaide, South Australia, Australia; Division of Human Immunology, Centre for Cancer Biology, University of South Australia and SA Pathology, South Australia, Australia.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Gregory
authors.affiliation: Institute of Health and Biomedical Innovation, Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Queensland University of Technology, Queensland, Australia.
authors.forename: Brett G
authors.initials: BG
authors.lastname: Hollier
authors.affiliation: Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, The University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, The University of Adelaide, South Australia, Australia; Discipline of Medicine, The University of Adelaide, South Australia, Australia.
authors.forename: Wayne D
authors.initials: WD
authors.lastname: Tilley
authors.affiliation: Dame Roma Mitchell Cancer Research Laboratories and Adelaide Prostate Cancer Research Centre, The University of Adelaide, South Australia, Australia; Freemasons Foundation Centre for Men's Health, The University of Adelaide, South Australia, Australia; Discipline of Medicine, The University of Adelaide, South Australia, Australia. Electronic address: luke.selth@adelaide.edu.au.
authors.forename: Luke A
authors.initials: LA
authors.lastname: Selth
mesh_terms: D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D011944:Receptors, Androgen / Q000378:metabolism; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D011944:Receptors, Androgen
keywords: androgen deprivation therapy; androgen receptor; chemotherapy; epithelial plasticity; epithelial–mesenchymal transition; mesenchymal–epithelial transition