title: Stereoselective synthesis of 4-substituted-cyclic sulfamidate-5-carboxylates by asymmetric transfer hydrogenation accompanied by dynamic kinetic resolution and applications to concise stereoselective syntheses of (-)-epi-cytoxazone and the taxotere side-chain.
abstract: Dynamic kinetic resolution driven, asymmetric transfer hydrogenation reactions of cyclic sulfamidate imine-5-carboxylate esters were developed. Applications of the new methodology to stereoselective syntheses of the taxotere side-chain and (-)-epi-cytoxazone are described.
authors.affiliation: Korea Chemical Bank, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong, Daejeon 305-600, Korea. leehk@krict.re.kr.
authors.forename: Jin-ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Yeon Ji
authors.initials: YJ
authors.lastname: Seo
authors.forename: Soyeong
authors.initials: S
authors.lastname: Kang
authors.forename: Juae
authors.initials: J
authors.lastname: Han
authors.forename: Hyeon-Kyu
authors.initials: HK
authors.lastname: Lee
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D000077143:Docetaxel; D006865:Hydrogenation; D007097:Imines / Q000737:chemistry*; D007700:Kinetics; D010080:Oxazoles / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism; D043823:Taxoids / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D007097:Imines; D010080:Oxazoles; D043823:Taxoids; D000077143:Docetaxel; C117832:cytoxazone; D012238:Rhodium