title: [Surgical resection of a huge gastric gastrointestinal stromal tumor after preoperative adjuvant chemotherapy].
abstract: A 73-year-old man was referred to our hospital because of positive results on a fecal occult blood test. He had severe anemia, and abdominal computed tomography (CT) revealed a huge 18 × 11 cm tumor in the lower gastric corpus. Pathological analysis of a biopsy sample revealed a gastrointestinal stromal tumor (GIST). We improved the nutritional and physical statuses via total parenteral and enteral nutrition. At the same time, we initiated preoperative adjuvant chemotherapy with 300 mg/day of imatinib. After 4 weeks' of treatment, CT revealed a drastic reduction in the tumor size, regarded a partial response (PR). The patient underwent partial gastrectomy, distal pancreatectomy, and partial resection of the transverse colon. His postoperative course was uneventful. The patient received postoperative treatment with imatinib for 1 year, and remained recurrence free for 10 months after surgery.
authors.affiliation: Dept. of Surgery, Toyohashi Municipal Hospital.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Minami
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: Takehito
authors.initials: T
authors.lastname: Kato
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shibata
authors.forename: Motoi
authors.initials: M
authors.lastname: Yoshihara
authors.forename: Seiji
authors.initials: S
authors.lastname: Natsume
authors.forename: Taro
authors.initials: T
authors.lastname: Aoba
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D005743:Gastrectomy; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate