title: [Transplantation of adipose tissue multipotent stromal cells in the treatment of chronic ischemia of the lower extremities].
abstract: The expediency of the stromal cells application, obtained from adipose tissue, was determined in a frame of preclinical investigations conduction, concerning experimental works on laboratory rats, in whom the extremity ischemia was simulated. Histologic and immunohistochemical changes were studied in muscular tissue after transplantation of multipotent stromal cells of own adipose tissue in patients, suffering ischemia of the lower extremity. Reduction of severity of the myofibrills ischemic damage, rapid activation of the muscles regenerative power, accurate stimulation of the angiogenesis processes in 3 mo after transplantation of the cells were demonstrated.
authors.forename: R V
authors.initials: RV
authors.lastname: Saliutin
authors.forename: S S
authors.initials: SS
authors.lastname: Palianytsia
authors.forename: V M
authors.initials: VM
authors.lastname: Sirman
authors.forename: L A
authors.initials: LA
authors.lastname: Panchenko
authors.forename: L S
authors.initials: LS
authors.lastname: Komarova
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007511:Ischemia / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery*; D007866:Leg / Q000098:blood supply / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D039902:Multipotent Stem Cells / Q000637:transplantation*; D018919:Neovascularization, Physiologic; D011859:Radiography; D033581:Stem Cell Transplantation / Q000379:methods*; D016896:Treatment Outcome; D014463:Ultrasonography; D014746:Vimentin / Q000096:biosynthesis; D014841:von Willebrand Factor / Q000096:biosynthesis
chemical_list: D014746:Vimentin; D014841:von Willebrand Factor