title: Factor V Leiden 1691G/A and prothrombin gene 20210G/A polymorphisms as prothrombotic markers in adult Egyptian acute leukemia patients.
abstract: Factor V Leiden 1691G/A and prothrombin gene 20210G/A mutations are the most common genetic defects leading to thrombosis. This work aimed to study the FV Leiden and the prothrombin gene polymorphism in adult Egyptian patients with acute leukemia and their importance in thrombophilia screening. The study included 76 patients with acute leukemia and 100 healthy controls. Genotyping was done by real-time polymerase chain reaction technique. For factor V Leiden, the frequency of G/A mutation conferred more than 2.5-fold of increased risk of (OR 2.639 95 % CI 1.045-6.669). The frequency of factor V Leiden combined (G/A + A/A) genotypes conferred 2.83-fold of increased risk (OR 2.828, CI 1.13-7.075), The A allele conferred almost threefold increased risk (OR 2.824, 95 % CI 1.175-6.785). Despite higher frequency in patients compared to controls, there was no risk of association between prothrombin gene mutation and acute leukemia in adult Egyptians nor was there between combined genotypes of prothrombin gene mutation and factor V Leiden.
authors.affiliation: National Cancer Institute, Cairo University, Giza, Egypt, aelsissy@yahoo.com.
authors.forename: Azza Hamdy
authors.initials: AH
authors.lastname: El Sissy
authors.forename: Maha H
authors.initials: MH
authors.lastname: El Sissy
authors.forename: Shereef
authors.initials: S
authors.lastname: Elmoamly
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D004534:Egypt / Q000453:epidemiology; D005165:Factor V / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D011516:Prothrombin / Q000235:genetics*; D013927:Thrombosis / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D055815:Young Adult
chemical_list: D005819:Genetic Markers; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin