title: Positive association of free triiodothyronine with pancreatic β-cell function in people with prediabetes.
abstract: OBJECTIVE
  To analyse the effects of thyroid hormones on β-cell function and glucose metabolism in people with prediabetes who are euthyroid.
  
  
  METHODS
  A total of 111 people who were euthyroid underwent 75-g oral glucose tolerance tests, of whom 52 were assigned to the normal glucose tolerance and 59 to the prediabetes groups. Homeostatic model assessment of β-cell function, insulinogenic index and areas under the curve for insulin and glucose were evaluated as indices of pancreatic β-cell function.
  
  
  RESULTS
  In both groups, BMI, fasting insulin, homeostasis model assessment ratio and HDL cholesterol correlated significantly with all indices of pancreatic β-cell function. Free triiodothyronine correlated positively with all insulin secretion indices in the prediabetes group. Multiple linear regression analysis showed that free triiodothyronine was an independent variable that had a positive correlation with all indices of β-cell function in the prediabetes group. By contrast, no such correlation was found in the normal glucose tolerance group.
  
  
  CONCLUSIONS
  Free triiodothyronine is associated with both basal and glucose-stimulated insulin secretion in people with prediabetes who are euthyroid; therefore, the regulation of insulin secretion by thyroid hormones is a potentially novel therapeutic target for the treatment of diabetes.
authors.affiliation: Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oda
authors.forename: H
authors.initials: H
authors.lastname: Taneichi
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Togashi
authors.forename: M
authors.initials: M
authors.lastname: Hangai
authors.forename: R
authors.initials: R
authors.lastname: Nakagawa
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Sasai
authors.forename: K
authors.initials: K
authors.lastname: Nagasawa
authors.forename: H
authors.initials: H
authors.lastname: Honma
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Takebe
authors.forename: Y
authors.initials: Y
authors.lastname: Ishigaki
authors.forename: J
authors.initials: J
authors.lastname: Satoh
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000150:complications; D011236:Prediabetic State / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D012720:Severity of Illness Index; D012995:Solubility; D013961:Thyroid Gland / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D008076:Cholesterol, HDL; D007328:Insulin; D014284:Triiodothyronine