title: Drug delivery: lessons to be learnt from Leishmania studies.
abstract: Leishmaniasis is a disease caused by infection with the protozoan parasite Leishmania, which is responsible for three main types of disease: cutaneous leishmaniasis, visceral leishmaniasis and mucocutaneous leishmaniasis based to the site of infection for the particular species. This presents a major challenge to successful drug treatment, as a drug must not only reach antileishmanial concentrations in infected macrophages, the parasites' host cell, but also reach infected cells in locations specific to the type of disease. In this paper we discuss how studies using Leishmania have contributed to our knowledge on how drug delivery systems can be used to improve drug efficacy and delivery.
authors.affiliation: Strathclyde Institute of Pharmacy & Biomedical Sciences University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, Scotland, UK.
authors.forename: C D
authors.initials: CD
authors.lastname: Shaw
authors.forename: K C
authors.initials: KC
authors.lastname: Carter
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects* / Q000502:physiology*; D007896:Leishmaniasis / Q000188:drug therapy* / Q000469:parasitology*; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size
chemical_list: D000981:Antiprotozoal Agents; D053769:Nanocapsules
keywords: drug delivery systems; intravenous; leishmaniasis; noninvasive