title: Cell reconstruction of the rectal mucosa in patients with familial adenomatous polyposis: endoscopy, morphology, immunohistochemistry.
abstract: We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells of the intestinal epithelium and mesenchymal cells of various origin is used. The mechanisms of mucosa reparation were studied in 34 patients. Endoscopic, morphological, and immunohistochemical studies showed that cell transplantation considerably accelerated reparation of the mucosa in mucosectomized rectum. The proposed treatment of familial colorectal adenomatous polyposis allows delaying the development of rectal polyps and cancer for many years.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Kogan
authors.forename: D V
authors.initials: DV
authors.lastname: Vyshegorodtsev
authors.forename: N M
authors.initials: NM
authors.lastname: Faizullina
authors.forename: T A
authors.initials: TA
authors.lastname: Demura
authors.forename: A M
authors.initials: AM
authors.lastname: Kuz'minov
authors.forename: Yu A
authors.initials: YA
authors.lastname: Shelygin
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000473:pathology*; D012007:Rectum / Q000473:pathology*