title: Effect of the FTO rs9930506 Polymorphism on the Main Comorbidities of the Cardiorenal Metabolic Syndrome in an Elderly Spanish Cohort.
abstract: OBJECTIVE
  Fat mass and obesity-associated (FTO) gene polymorphisms have been linked to the risk of obesity and diabetes, two well-recognized risk factors for renal disease. Our aim was to determine whether a common FTO polymorphism was associated with a reduced estimated glomerular filtration rate (eGFR) independently of body mass index (BMI) and type 2 diabetes mellitus (T2DM) in a cohort of elderly individuals from the region of Asturias (Northern Spain; RENASTUR cohort).
  
  
  METHODS
  A total of 544 Spanish Caucasians aged 55-85 years were genotyped for the FTO rs9930506 single-nucleotide polymorphism (SNP). Individuals with a previous diagnosis of renal disease were not eligible for the study. The eGFR was calculated with the Modification of Diet in Renal Disease formula, and individuals with an eGFR of <60 ml/min/1.73 m(2) (n = 91) were considered as having impaired renal function. The effect of alleles and genotypes on BMI, hypertension, diabetes, eGFR and blood lipid values was statistically determined.
  
  
  RESULTS
  The rs9930506 GG genotype was significantly more common in the group with a BMI of >25 (p = 0.03; odds ratio = 2.43; 95% CI: 1.09-5.43). Age and T2DM were significant risk factors for a reduced eGFR, but neither obesity nor the FTO genotypes were associated with a reduced eGFR.
  
  
  CONCLUSIONS
  The common FTO rs9930506 polymorphism was a risk factor for overweight and obesity in the RENASTUR cohort. However, this SNP was not associated with other comorbidities of the cardiorenal metabolic syndrome in this population.
authors.affiliation: Genética Molecular-Laboratorio Medicina-Fundación Renal (IRSIN-FRIAT), Oviedo, Spain ; Departamento de Medicina, Universidad Oviedo, Oviedo, Spain.
authors.forename: Eliecer
authors.initials: E
authors.lastname: Coto
authors.affiliation: Genética Molecular-Laboratorio Medicina-Fundación Renal (IRSIN-FRIAT), Oviedo, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Tavira
authors.affiliation: Genética Molecular-Laboratorio Medicina-Fundación Renal (IRSIN-FRIAT), Oviedo, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Gómez
authors.affiliation: Centro de Salud El Cristo, Universidad Oviedo, Oviedo, Spain.
authors.forename: Salvador
authors.initials: S
authors.lastname: Tranche
authors.affiliation: Nefrología, Hospital Universitario Central de Asturias, Oviedo, Spain ; Departamento de Medicina, Universidad Oviedo, Oviedo, Spain.
authors.forename: Carmen Díaz
authors.initials: CD
authors.lastname: Corte
keywords: Body mass index; FTO polymorphisms; Glomerular filtration; Obesity; Renal function