title: Protective effect of huoxiang zhengqi oral liquid on intestinal mucosal mechanical barrier of rats with postinfectious irritable bowel syndrome induced by acetic Acid.
abstract: In this study, a rat model with acetic acid-induced PI-IBS was used to study the role of HXZQ oral liquid in repairing the colonic epithelial barrier and reducing intestinal permeability. Pathomorphism of colonic tissue, epithelial ultrastructure, DAO activity in serum, and the protein expression of ZO-1 and occludin were examined to investigate protective effect mechanisms of HXZQ on intestinal mucosa barrier and then present experimental support for its use for prevention and cure of PI-IBS.
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ; New Drug Research and Development Center, Guangdong Institute of Traditional Chinese Medicine, Guangzhou 510520, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Liu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China ; Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
authors.forename: Qiu-Xian
authors.initials: QX
authors.lastname: Peng
authors.affiliation: College of Pharmacy, Hunan University of Traditional Chinese Medicine, Changsha 410028, China.
authors.forename: Jiang-Li
authors.initials: JL
authors.lastname: Peng
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Lin-Zhong
authors.initials: LZ
authors.lastname: Yu
authors.affiliation: School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
authors.forename: Jian-Lan
authors.initials: JL
authors.lastname: Hu