title: [Superior vena cava thrombosis in patients with mediastinal large B-cell lymphoma: two pediatric cases].
abstract: We report two pediatric cases of superior vena cava thrombosis (VTE) in patients treated for primary mediastinal large B-cell lymphoma (PMBCL). PMBCL is a rare entity in children and adolescents and no thrombosis has been described in this population. Thrombosis in lymphoma is frequently asymptomatic, detected as an incidental finding in the first months following diagnosis. The thrombosis mechanisms are often multifactorial based on veinous compression by the mass, elevated risk of thrombosis in neoplasia, and/or presence of a central catheter. The risk factors of venous thromboembolism (VTE) in lymphoma are high-grade lymphoma, comorbidities, central nervous system lymphoma, and mediastinal mass. Because thrombosis has an impact on prognosis and treatment, it seems important to improve knowledge in order to improve the diagnosis and prevention of thrombosis in lymphoma.
authors.affiliation: Université Lille Nord de France, 59000 Lille, France; Unité d'hématologie pédiatrique, CHU de Lille, 59000 Lille, France. Electronic address: fannycharlottegonzales@gmail.com.
authors.forename: F
authors.initials: F
authors.lastname: Gonzales
authors.affiliation: Université Lille Nord de France, 59000 Lille, France; Unité d'hématologie pédiatrique, CHU de Lille, 59000 Lille, France.
authors.forename: W
authors.initials: W
authors.lastname: Abou Chahla
authors.affiliation: Service de radiologie thoracique, CHU de Lille, 59000 Lille, France.
authors.forename: J
authors.initials: J
authors.lastname: Pagniez
authors.affiliation: Unité d'hématologie pédiatrique, CHU de Lille, 59000 Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Nelken
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications*; D008479:Mediastinal Neoplasms / Q000150:complications*; D011859:Radiography; D013479:Superior Vena Cava Syndrome / Q000000981:diagnostic imaging / Q000209:etiology*