title: Effect of NO synthase blockade on NO production in rat heart under conditions of hypokinesia.
abstract: Electron paramagnetic (EPR) spectroscopy study showed that 90-day hypokinesia in rats is accompanied by an increase in NO production in the heart. A nonselective NO synthase inhibitor L-NAME decreased the content of NO in the heart atria and ventricles of hypokinetic rats by 67-70%. A selective inhibitor of inducible NO synthase, aminoguanidine, also decreased the level of NO in the heart atria and ventricles of hypokinetic rats by 60-65%. Our results indicate that the increase in NO production during hypokinesia is associated with activation of NO synthases.
authors.affiliation: Department of Anatomy Physiology, and Human Health Protection, Kazan (Volga Region) Federal University, Kazan, Russia, ratno1992@mail.ru.
authors.forename: R I
authors.initials: RI
authors.lastname: Zaripova
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
mesh_terms: D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D007103:Immobilization; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D051381:Rats
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase