title: Effect of Binghuang ear drop treatment on otitis externa in guinea pigs.
abstract: To investigate the pharmacodynamic effects of Binghuang ear drop on acute suppurative otitis externa in guinea pig model. Thirty guinea pigs were randomly divided into three groups, with ten animals in each group. Group A animals had normal ear canal and Binghuang ear drops (two drops, B.I.D) were applied in both ears for 7 days; Group B animals had induced otitis externa and received identical prescription as group A; Group C had normal ear canal and were treated with normal saline (two drops, B.I.D) for 7 days. After the treatments, the external morphology of ear canals was observed and the paraffin sections of external auditory canal were prepared and examined under the microscope. The inflammatory manifestation and cell infiltration into the skin of group B was significantly attenuated after the Binghuang ear drops treatment. In contrast, no allergy or side effects were produced by Binghuang ear drops application in the animals with normal ear canals. Binghuang ear drops could be used to treat acute otitis externa by eliciting anti-bacterial effects.
authors.affiliation: Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing, 100853, China, zhaisq@301hospital.com.cn.
authors.forename: Suo-qiang
authors.initials: SQ
authors.lastname: Zhai
authors.forename: Ning
authors.initials: N
authors.lastname: Yu
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Guo
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000208:Acute Disease; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D004195:Disease Models, Animal; D004424:Ear Canal / Q000187:drug effects / Q000473:pathology; D006168:Guinea Pigs; D006207:Half-Life; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000472:pathogenicity; D010032:Otitis Externa / Q000209:etiology / Q000473:pathology*; D012965:Sodium Chloride / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D012965:Sodium Chloride