title: Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking.
abstract: Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved.
authors.affiliation: Department of Infection and Immunity, School of Medicine and Biomedical Sciences, The University of Sheffield, Sheffield, S102RX, United Kingdom.
authors.forename: Lorena
authors.initials: L
authors.lastname: Preciado-Llanes
authors.forename: James B
authors.initials: JB
authors.lastname: Wing
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Foster
authors.forename: Jennifer
authors.initials: J
authors.lastname: Carlring
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Heath
keywords: B cells; Immune regulation; T cells