title: Bioassay directed isolation and biological evaluation of compounds isolated from Rubus fairholmianus Gard.
abstract: The in vitro and in silico analysis of Rubus fairholmianus acetone extract for antioxidant, antiproliferative, and anti-inflammatory activity led to the isolation of six compounds. Amongst all the six isolated compounds tested, 1-(2-hydroxyphenyl)-4-methylpentan-1-one (compound 1) and 2-[(3-methylbutoxy) carbonyl] benzoic acid (compound 2) were found to be more active in inhibiting BRCA and COX target proteins, which also showed the better results for DPPH and ABTS radical scavenging assays. The promising results of this investigation emphasize the importance of using R. fairholmianus in the treatment of radical generated disorders mainly cancer and other inflammatory diseases.
authors.affiliation: Bioprospecting Laboratory, Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India.
authors.forename: Blassan
authors.initials: B
authors.lastname: Plackal George
authors.affiliation: Bioprospecting Laboratory, Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India.
authors.forename: Parimelazhagan
authors.initials: P
authors.lastname: Thangaraj
authors.affiliation: Phytochemistry Division, Centre for Medicinal Plants Research, Arya Vaidya Sala, Kottakkal 676 503, India.
authors.forename: Cheruthazhakkatt
authors.initials: C
authors.lastname: Sulaiman
authors.affiliation: Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India.
authors.forename: Shanmughavel
authors.initials: S
authors.lastname: Piramanayagam
authors.affiliation: Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu 641 046, India.
authors.forename: Sathish Kumar
authors.initials: SK
authors.lastname: Ramaswamy
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001681:Biological Assay; D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D062105:Molecular Docking Simulation; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D065856:Rubus / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010936:Plant Extracts