title: [Residues and health risk assessment of sulfonamides in sediment and fish from typical marine aquaculture regions of Guangdong Province, China].
abstract: Concentrations of sulfonamides including sulfadiazine (SDZ), sulfadimidin (SM2) and sulfamethoxazole (SMX) in sediments, muscle and liver tissues of 7 kinds of fish species collected from two marine aquaculture regions along the coast of Guangdong Provice were determined by high performance liquid chromatography (HPLC) equipped with a ultraviolet detector. Assessment of the health risks were conducted based on the values of maximum residue limits (MRL) and acceptable daily intake (ADI). The results showed that sulfonamides were found in all the sediment samples. The concentrations (dry wet) ranged from 2.1 - 35.2 ng x g(-1), the detected frequency of the 3 sulfonamide antibiotics ranked as SDZ (85.7%) > SM2 (71.4%) > SMX (28.6%). The detection rate of sulfonamides in samples from Daya Bay was higher than that from Hailing Island. Higher concentrations were detected in liver tissues rather than in muscle tissues (P < 0.05). The residues of SDZ, SM2 and SMX in fish muscle tissues (wet weight) ranged from 11.6-37.9, 16.3-27.8 and 4.9-20.0 ng x g(-1), respectively. The calculated daily intakes of sulfonamides in the present study ranged from 3.37-36.72 ng x kg(-1), which accounted for 0.007% -0.073% of the ADI (50 microg x kg(-1)). Health risks to human body were negligible as the estimated intake was less than 1% ADI, therefore the security of dietary was high.
authors.forename: Xiu-Ting
authors.initials: XT
authors.lastname: He
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiang-Ping
authors.initials: XP
authors.lastname: Nie
authors.forename: Yong-Tao
authors.initials: YT
authors.lastname: Yang
authors.forename: Zhang
authors.initials: Z
authors.lastname: Cheng
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis; D017756:Aquaculture; D002681:China; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis; D004784:Environmental Monitoring; D005399:Fishes; D019015:Geologic Sediments / Q000737:chemistry*; D006801:Humans; D018570:Risk Assessment; D013449:Sulfonamides / Q000032:analysis*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides; D014874:Water Pollutants, Chemical