title: The current research status of normal tension glaucoma.
abstract: Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.
authors.affiliation: Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China ; Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Xue-Song
authors.initials: XS
authors.lastname: Mi
authors.affiliation: School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
authors.forename: Ti-Fei
authors.initials: TF
authors.lastname: Yuan
authors.affiliation: Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China ; Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China ; GHM Institute of CNS Regeneration, Jinan University, Guangzhou, People's Republic of China.
authors.forename: Kwok-Fai
authors.initials: KF
authors.lastname: So
mesh_terms: D000368:Aged; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004252:DNA Mutational Analysis; D004195:Disease Models, Animal; D005123:Eye / Q000098:blood supply; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D057066:Low Tension Glaucoma / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D008297:Male; D008822:Mice, Transgenic; D011379:Prognosis; D012171:Retinal Vessels / Q000503:physiopathology; D012307:Risk Factors; D015398:Signal Transduction
keywords: aging; genetics; neurovascular unit; primary open-angle glaucoma; treatment