title: [Lignans isolated from stems of Sambucus williamsii and their proliferation effects on UMR106 cells].
abstract: The present study aims to investigate the lignan constituents from Sambucus williamsii and their proliferation effects on osteoblast-like UMR106 cells. Seven compounds were isolated and purified by macroporous resin D101, silica gel, Sephadex LH-20, Toyopearl HW-40, ODS column chromatographies and Preparative HPLC(C-18). Their structures were elucidated by spectroscopic methods as threo-guaiacylglycerol-beta-0-4'-conifery ether (1), lirioresinol A (2), 1-hydroxypinoresinol (3), 5-methoxybalanophonin (4), balanophonin (5), 5-methoxy-trans-dihydrodehydrodiconiferyl alcohol (6), and p-hydroxybenzaldehyde (7). Compounds 3-7 were obtained from this genus for the first time. The proliferation effects of all isolated compounds on osteoblast-like UMR106 cells were determined. Compounds 1-7 (1 x 10(-12)-1 x 10(-7) mol x L(-1)) increased UMR106 cell proliferation to some extent.
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Xu
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Duan
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Xiao
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Wang
authors.forename: Man-Sau
authors.initials: MS
authors.lastname: Wong
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology*; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects*; D018547:Plant Stems / Q000737:chemistry*; D027923:Sambucus / Q000737:chemistry*
chemical_list: D017705:Lignans