title: Interaction between type I interferon and Cyprinid herpesvirus 3 in two genetic lines of common carp Cyprinus carpio.
abstract: Cyprinid herpesvirus 3 (CyHV-3) infection in common carp Cyprinus carpio L. and its ornamental koi varieties can induce the severe systemic disease known as koi herpesvirus disease. This disease is characterised by a rapid replication and spreading of the virus through multiple organs and results in a fast onset of mortality (starting on Day 6 post infection) in up to 100% of infected fish. During the first phase of viral infections, type I interferons (IFNs) have generally been proven to be essential in inducing an innate immune response; however, very little is known about the type I IFN response to herpesviruses in fish. The aim of this work was to study the type I IFN responses during CyHV-3 infection in 2 genetically divergent lines of common carp which presented differing survival rates. Our results show that CyHV-3 induced a systemic type I IFN response in carp, and the magnitude of type I IFN expression is correlated with the virus load found in skin and head kidney. In this in vivo experimental setup, the level of type I IFN response cannot be linked with higher survival of carp during CyHV-3 infection.
authors.affiliation: Fish Disease Research Unit, Centre of Infectious Diseases, University of Veterinary Medicine Hannover, Bünteweg 17, 30559 Hannover, Germany.
authors.forename: Mikołaj
authors.initials: M
authors.lastname: Adamek
authors.forename: Krzysztof L
authors.initials: KL
authors.lastname: Rakus
authors.forename: Graham
authors.initials: G
authors.lastname: Brogden
authors.forename: Marek
authors.initials: M
authors.lastname: Matras
authors.forename: Jarosław
authors.initials: J
authors.lastname: Chyb
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hirono
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kondo
authors.forename: Takashi
authors.initials: T
authors.lastname: Aoki
authors.forename: Ilgiz
authors.initials: I
authors.lastname: Irnazarow
authors.forename: Dieter
authors.initials: D
authors.lastname: Steinhagen
mesh_terms: D000818:Animals; D002347:Carps / Q000235:genetics*; D005393:Fish Diseases / Q000235:genetics / Q000821:virology*; D005786:Gene Expression Regulation / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006564:Herpesviridae / Q000145:classification*; D006566:Herpesviridae Infections / Q000235:genetics / Q000662:veterinary* / Q000821:virology; D007370:Interferon Type I / Q000378:metabolism*
chemical_list: D007370:Interferon Type I