title: Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid.
abstract: IsoGNA, an isomer of glycerol nucleic acid GNA, is a flexible (acyclic) nucleic acid with bases directly attached to its linear backbone. IsoGNA exhibits (limited) base-pairing properties which are unique compared to other known flexible nucleic acids. Herein, we report on the details of the preparation of isoGNA phosphoramidites and an alternative route for the synthesis of the adenine derivative. The synthetic improvements described here enable an easy access to isoGNA and allows for the further exploration of this structural unit in oligonucleotide chemistry thereby spurring investigations of its usefulness and applicability.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Keunsoo
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Venkateshwarlu
authors.initials: V
authors.lastname: Punna
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Phaneendrasai
authors.initials: P
authors.lastname: Karri
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.
authors.forename: Ramanarayanan
authors.initials: R
authors.lastname: Krishnamurthy
keywords: acyclic nucleic acids; glycerol nucleic acids; isoGNA; oligonucleotides; phosphoramidites