title: [Two cases of Wernicke´s encephalopathy that developed during total parenteral nutrition in colon cancer patients treated with 5-fluorouracil-based chemotherapy].
abstract: Wernicke's encephalopathy (WE) caused by thiamine deficiency is an acute neurological disorder. Clinically, the classic triad of WE consists of ophthalmoplegia, ataxia, and mental status changes. Thiamine deficiency is known to occur commonly in chronic alcoholic patients. Sometimes, it can occur in patients after gastrointestinal surgery and in those with malabsorption. In addition, patients undergoing renal dialysis, suffering from hyperemesis gravidarum, receiving total parenteral nutrition (TPN), and being treated with chemotherapeutic agents are also prone to develop thiamine deficiency. Herein, we report two cases of WE that developed following simultaneous 5-fluorouracil (5-FU) chemotherapy and TPN in colon cancer patients which was successfully treated with thiamine administration.
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Kyung Pyo
authors.initials: KP
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Ji Seok
authors.initials: JS
authors.lastname: Seong
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Yong Moon
authors.initials: YM
authors.lastname: Woo
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Seoul Red Cross Hospital, Seoul, Korea.
authors.forename: Beom Jin
authors.initials: BJ
authors.lastname: Jeong
authors.affiliation: Division of Public Health Medical Service, Seoul National University Hospital, Seoul, Korea.
authors.forename: Jee Hoon
authors.initials: JH
authors.lastname: Sohn
authors.affiliation: Division of Public Health Medical Service, Seoul National University Hospital, Seoul, Korea.
authors.forename: Su-Jung
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total; D011859:Radiography; D013831:Thiamine / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D014803:Vitamin B Complex; D005472:Fluorouracil; D013831:Thiamine
keywords: Colonic neoplasms; Fluorouracil; Thiamine; Total parenteral nutrition; Wernicke encephalopathy