title: [Electroconvulsive therapy for the treatment of major depression].
abstract: BACKGROUND
  Depressive disorders are common and lead to both individual suffering and high socioeconomic costs. Despite the fact that several effective therapies are available, remission is often not achieved. Electroconvulsive therapy (ECT) can be a therapeutic option in these cases.
  
  
  OBJECTIVE
  This review outlines the current evidence for the efficacy, safety and tolerability of ECT for depressive disorders.
  
  
  METHODS
  A selective literature search was carried out with particular consideration of meta-analyses, systematic reviews, and recommendations of national and international therapy guidelines.
  
  
  RESULTS
  For the majority of patients ECT is an effective, safe and well-tolerated therapy for the treatment of depressive disorders. There are relatively high remission rates even in patients with pharmacoresistant depression. There is evidence for a particularly high responsiveness in specific populations. In contrast to the proven effectiveness in the acute treatment of depressive disorders, there is a relative lack of data concerning maintenance therapy. Side effects including cognitive deficits are mostly transient. Modifications in the ECT technique have an impact on effectiveness and tolerability.
  
  
  CONCLUSIONS
  When administered correctly ECT is a highly effective therapy for the treatment of depressive disorders. In the light of the abundance of depressive disorders and lack of remission despite adequate pharmacological treatment, a broader availability and application of ECT would be desirable. The same is true for a more intensive research into the mechanisms of action and response predictors of ECT.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, Universitätsmedizin Göttingen, Von-Siebold-Str. 5, 37075, Göttingen, Deutschland, david.zilles@med.uni-goettingen.de.
authors.forename: D
authors.initials: D
authors.lastname: Zilles
authors.forename: C
authors.initials: C
authors.lastname: Wolff-Menzler
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
mesh_terms: D003072:Cognition Disorders / Q000209:etiology* / Q000517:prevention & control; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000009:adverse effects* / Q000379:methods*; D019317:Evidence-Based Medicine; D006261:Headache / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D018579:Patient Selection; D016896:Treatment Outcome