title: Roles of F-box proteins in human digestive system tumors (Review).
abstract: F-box proteins (FBPs), the substrate-recognition subunit of E3 ubiquitin (Ub) ligase, are the important components of Ub proteasome system (UPS). FBPs are involved in multiple cellular processes through ubiquitylation and subsequent degradation of their target proteins. Many studies have described the roles of FBPs in human cancers. Digestive system tumors account for a large proportion of all the tumors, and their mortality is very high. This review summarizes for the first time the roles of FBPs in digestive system tumorige-nesis and tumor progression, aiming at finding new routes for the rational design of targeted anticancer therapies in digestive system tumors.
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gong
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Liang
authors.initials: L
authors.lastname: Lv
authors.affiliation: Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
authors.forename: Jirong
authors.initials: J
authors.lastname: Huo
mesh_terms: D063646:Carcinogenesis; D004064:Digestive System / Q000473:pathology*; D044783:F-Box Proteins / Q000235:genetics*; D005770:Gastrointestinal Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*; D054875:Ubiquitination
chemical_list: D044783:F-Box Proteins; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex