title: Cytological analysis of uterine body endometrioid adenocarcinoma cells in peritoneal cavity: cytological findings and histological background.
abstract: OBJECTIVE
  We analyzed uterine-body endometrioid adenocarcinoma (EMA) cells appearing in the peritoneal cavity with special reference to squamous metaplastic-like cells (SMCs).
  
  
  METHODS
  Cases were 33 EMA specimens surgically resected from 2000 to 2006 and consisting of 17 G1 (51.5%), 13 G2 (39.4%), and 3 G3 (9.1%). Focusing on SMCs using immunohisto/cytochemical tests, we analyzed cytohistological findings and their association with pathological conditions such as histological grade, depth, tumor size, and location.
  
  
  RESULTS
  Peritoneal cytological findings were as follows: large to small papillary G1 or G2 clusters and scattered G3 patterns. With Papanicolaou staining, SMCs showed slight atypia and were polygonal to oval cells that had central nuclei. These cells also showed an increase of fine granular chromatin and had small nuclei. The tumor cells had abundant cytoplasm, which was densely stained with a light green, and their boundaries were well defined. The prevalence of SMCs relative to adenocarcinoma cells was 1+ in 33.3% (6 patients), 2+ in 55.6% (10 patients), and 3+ in 11.1% (2 patients). These features were found not to be related to invasion depth or tumor size.
  
  
  CONCLUSIONS
  SMCs appears to be a hallmark in peritoneal uterine-body EMA cytology, especially in G1 or G2 diagnosis.
authors.forename: Naruaki
authors.initials: N
authors.lastname: Matsui
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kajiwara
authors.forename: Hitomi
authors.initials: H
authors.lastname: Tsukada
authors.forename: Kazumi
authors.initials: K
authors.lastname: Nakazawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Mikami
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Pathology, Tokai University Oiso Hospital, Gakkyo 21-1, Oiso-machi, Nakagun, Kanagawa 259-0198, Japan. sato@oiso.u-tokai.ac.jp.
authors.forename: Shinkichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000328:Adult; D018269:Carcinoma, Endometrioid / Q000473:pathology*; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010529:Peritoneal Cavity / Q000473:pathology*; D014594:Uterine Neoplasms / Q000473:pathology*