title: Effect of aerobic exercise training on cardiovascular parameters and CD4 cell count of people living with human immunodeficiency virus/acquired immune deficiency syndrome: a randomized controlled trial.
abstract: OBJECTIVE
  Despite the significant positive effect of Highly Active Antiretroviral Therapy on physical and psychosocial well-being of people living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) (PLWHA); decreased physical activity and its associated cardiovascular risk still pose some consequences for health and general well-being. This study investigated the effect of an 8 week aerobic exercise training on cardiovascular parameters and CD4 cell (T-cells) count of PLWHA.
  
  
  METHODS
  This randomized controlled trial recruited 30 age matched PLWHA who were randomly assigned into exercise group (EG) ( n = 15) and control group (CG) ( n = 15) respectively. The PLWHA were patients receiving treatment in President's Emergency Plan for AIDS relief at the HIV clinic of the University of Nigeria Teaching Hospital, Nigeria. The EG in addition to conventional therapy received moderate intensity continuous exercise training (60-79% of the maximum heart rate [max]) of between 45 and 60 min, 3 times/week for 8 weeks, while the CG received conventional therapy involving antiretroviral therapy and counseling only. Systolic blood pressure (SBP), diastolic blood pressure (DBP), maximum oxygen uptake (VO₂ max) and CD4 cell count were assessed at baseline (week 1) and week 8 respectively. Analysis of co-variance and Pearson correlation tests were used in data analysis.
  
  
  RESULTS
  Findings of the study revealed a significant effect (ANCOVA test) of moderate intensity continuous exercise training program on, SBP, DBP, VO₂ max and CD4 cell count at P < 0.05. Changes in VO₂ max significantly correlated (Pearson correlation test) with changes in CD4 cell count ( r = 0.528) at P < 0.05.
  
  
  CONCLUSIONS
  Moderate intensity aerobic exercise is an effective complementary therapy in lowering blood pressure and increasing CD4 cell count in PLWHA.
authors.forename: C I
authors.initials: CI
authors.lastname: Ezema
authors.forename: A A
authors.initials: AA
authors.lastname: Onwunali
authors.affiliation: Departments of Medical Rehabilitation, Faculty of Health Sciences and Technology, University of Nigeria, Enugu, Nigeria.
authors.forename: S
authors.initials: S
authors.lastname: Lamina
authors.forename: U A
authors.initials: UA
authors.lastname: Ezugwu
authors.forename: A A
authors.initials: AA
authors.lastname: Amaeze
authors.forename: M J
authors.initials: MJ
authors.lastname: Nwankwo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000503:physiopathology* / Q000628:therapy; D000328:Adult; D001794:Blood Pressure; D018791:CD4 Lymphocyte Count; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010101:Oxygen Consumption; D055815:Young Adult