title: Bilateral optic neuropathy associated with the tumor necrosis factor-alpha inhibitor golimumab.
abstract: A 62-year-old man developed bilateral blurred vision associated with bilateral optic disc swelling shortly after receiving his third dose of the tumor necrosis factor-alpha (TNF-α) inhibitor golimumab, that he took for psoriatic arthritis. An extensive assessment including magnetic resonance imaging, lumbar puncture, and serologies was negative. He was treated with systemic corticosteroids and the golimumab was stopped, after which his vision improved and his disc swelling resolved. We postulate that the bilateral, simultaneous anterior optic neuropathies in this patient were due to golimumab, representing a rare but well-documented serious adverse event associated with TNF-α inhibitors.
authors.affiliation: Department of Ophthalmology (JRC, NRM), the Johns Hopkins University School of Medicine, Baltimore, Maryland.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Chang
authors.forename: Neil R
authors.initials: NR
authors.lastname: Miller
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D007155:Immunologic Factors; D014409:Tumor Necrosis Factor-alpha; C529000:golimumab