title: Evaluation of the ability of xanthan gum/gellan gum/hyaluronan hydrogel membranes to prevent the adhesion of postrepaired tendons.
abstract: After tendon-repair surgery, adhesion between the surgical tendon and the synovial sheath is often presented resulting in poor functional repair of the tendon. This may be prevented using a commercially available mechanical barrier implant, Seprafilm, which is composed of hyaluronan (HA) and carboxymethyl cellulose hydrogels. In a rat model, prepared membranes of various compositions of gellan gum (GG), xanthan gum (XG) and HA as well as Seprafilm were wrapped around repaired tendons and the adhesion of the tendons was examined grossly and histologically after 3 weeks of healing. Certain formulations of the XG/GG/HA hydrogel membranes reduced tendon adhesion with equal efficacy but without reducing the tendon strength compared to Seprafilm. The designed membranes swelled rapidly and blanketed onto the tendon tissue more readily and closely than Seprafilm. Also they degraded slowly, which allowed the membranes to function as barriers for extended periods.
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Shyh Ming
authors.initials: SM
authors.lastname: Kuo
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Shwu Jen
authors.initials: SJ
authors.lastname: Chang
authors.affiliation: Center for General Education, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Wang
authors.affiliation: Department of Biomedical Engineering, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Shu Ching
authors.initials: SC
authors.lastname: Tang
authors.affiliation: Department of Orthopedics, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung, Taiwan; School of Nursing, Fooyin University, Kaohsiung, Taiwan. Electronic address: yangshanwei@yahoo.com.tw.
authors.forename: Shan-Wei
authors.initials: SW
authors.lastname: Yang
mesh_terms: D000818:Animals; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry* / Q000627:therapeutic use*; D020100:Hydrogels / Q000737:chemistry*; D008297:Male; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013710:Tendons / Q000166:cytology* / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D020100:Hydrogels; D011135:Polysaccharides, Bacterial; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C048288:gellan gum; C002563:xanthan gum
keywords: Anti-adhesion; Gellan gum; Hyaluronan; Tendon; Xanthan gum