title: Emotion circuits differentiate symptoms of psychosis versus mania in adolescents.
abstract: The diagnostic boundary between schizophrenia and bipolar disorder can be unclear, particularly with early onset. We assessed if emotion brain circuits differentiate psychosis versus mania symptoms in a series of six early onset patients. Symptoms were dissociated by direction, awareness condition, and brain regions. Greater psychosis symptoms were correlated with greater prefrontal, anterior cingulate, amygdala, and fusiform face area activation during masked fear processing. By contrast, greater mania symptoms were correlated with less amygdala activation during unmasked fear and happy processing. This suggests emotion dysfunction in schizophrenia versus bipolar disorder may arise from partially distinct neural mechanisms of susceptibility.
authors.affiliation: a Brain Dynamics Centre, Sydney Medical School and Westmead Millennium Institute , University of Sydney at Westmead , Sydney , NSW , Australia.
authors.forename: Annie M
authors.initials: AM
authors.lastname: Brennan
authors.forename: Cassandra
authors.initials: C
authors.lastname: Hainsworth
authors.forename: Jean
authors.initials: J
authors.lastname: Starling
authors.forename: Mayuresh S
authors.initials: MS
authors.lastname: Korgaonkar
authors.forename: Anthony W F
authors.initials: AW
authors.lastname: Harris
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Williams
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000503:physiopathology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D000066499:Facial Recognition / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000503:physiopathology; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000503:physiopathology* / Q000523:psychology; D013702:Temporal Lobe / Q000503:physiopathology; D055815:Young Adult
keywords: early onset; emotion; fMRI; mania; psychosis