title: Prevalence of microvascular diseases among tertiary care Chinese with early versus late onset of type 2 diabetes.
abstract: OBJECTIVE
  This study aimed to investigate the impact of early-onset diabetes on the risk of microvascular diseases in Chinese with type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  A cross sectional survey of 29,442 patients with T2DM in 77 tertiary hospitals in China was conducted in 2011. Early-onset diabetes was defined as diagnosis of diabetes before 40years of age. Microvascular complications and risk factors were documented. Prevalence of microvascular disease was standardized to the Chinese population in 2010. Logistic regression analysis was performed to obtain odds ratios (OR) for early versus late onset of T2DM.
  
  
  RESULTS
  A total of 1,303 (4.4%) patients had nephropathy, 2,137 (7.3%) had retinopathy and 3,012 (10.2%) had either of them. Early-onset diabetes greatly increased the prevalence of microvascular diseases compared with late-onset diabetes (nephropathy: 5.1% vs. 1.5%; retinopathy: 7.1% vs. 2.7%; either: 9.7% vs. 3.6%), especially among patients from 45 to 59years of age. After adjusting for age and sex, patients with early-onset T2DM were at 1.69-fold (95% CI 1.46-1.95) higher risk of microvascular diseases than those with late-onset T2DM. However, this was not significant after adjusting for traditional risk factors and disease duration (p=0.162).
  
  
  CONCLUSIONS
  Chinese patients with early-onset T2DM are at a marked increased risk of microvascular diseases.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Endocrinology and metabolism, Peking University People's Hospital, Beijing, China.
authors.forename: Linong
authors.initials: L
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Peking University First Hospital, Beijing, China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Guo
authors.affiliation: Department of Endocrinology, Xijing Hospital affiliated to 4th Military Medical University, Xi'an, China.
authors.forename: Qiuhe
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Department of Endocrinology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Gu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China.
authors.forename: Xinyue
authors.initials: X
authors.lastname: Zhi
authors.affiliation: Department of Endocrinology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Kuang
authors.affiliation: Department of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
authors.forename: Benli
authors.initials: B
authors.lastname: Su
authors.affiliation: Department of Endocrinology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Yan
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address: yxl@hotmail.com.
authors.forename: Xilin
authors.initials: X
authors.lastname: Yang
mesh_terms: D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D044466:Asian People / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000175:diagnosis / Q000453:epidemiology*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000453:epidemiology*; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D015995:Prevalence; D012720:Severity of Illness Index; D017678:Sex Distribution; D062606:Tertiary Care Centers
keywords: Chinese; Early-onset; Microvascular diseases; Prevalence; Type 2 diabetes mellitus