title: Identification and characterization of the antifungal substances of a novel Streptomyces cavourensis NA4.
abstract: A new actinomycete strain NA4 was isolated from a deep-sea sediment collected from the South China Sea and showed promising antifungal activities against soilborne fungal pathogens. It was identified as Streptomyces cavourensis by morphological, physiological, and phylogenetic analyses based on its 16S rRNA gene sequence. The main antifungal components were isolated and identified from the fermentation culture as bafilomycins B1 and C1. These compounds exhibited significant antifungal activities and a broad antifungal spectrum. The results suggest that the Streptomyces cavourensis NA4 and bafilomycins B1 and C1 could be used as potential biocontrol agents for soilborne fungal diseases of plants.
authors.affiliation: Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, P.R. China, Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, P.R. China.
authors.forename: Hua-Qi
authors.initials: HQ
authors.lastname: Pan
authors.forename: Su-Ya
authors.initials: SY
authors.lastname: Yu
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Song
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Jiang-Chun
authors.initials: JC
authors.lastname: Hu
authors.forename: Shu-Jin
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D061046:Biological Control Agents / Q000302:isolation & purification*; D002681:China; D019015:Geologic Sediments / Q000382:microbiology; D018942:Macrolides / Q000302:isolation & purification*; D010802:Phylogeny; D010935:Plant Diseases / Q000382:microbiology / Q000517:prevention & control; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D061046:Biological Control Agents; D018942:Macrolides; D012336:RNA, Ribosomal, 16S; C052501:bafilomycin B1; C052502:bafilomycin C1