title: Gender-dependent association of HSD11B1 single nucleotide polymorphisms with glucose and HDL-C levels.
abstract: In this study, we investigated the influence of two SNPs (rs846910 and rs12086634) of the HSD11B1 gene that encodes 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1), the enzyme that catalyzes the conversion of cortisol to cortisone, on variables associated with obesity and metabolic syndrome in 215 individuals of both sexes from southern Brazil. The HSD11B1 gene variants were genotyped using the TaqMan SNP genotyping assay. Glucose, triglycerides, total cholesterol, HDL-cholesterol and LDL-cholesterol were measured by standard automated methods. Significant results were found in women, with carriers of the G allele of SNP rs12086634 having higher glucose levels than non-carriers. Carriers of the A allele of SNP rs846910 had higher levels of HDL-cholesterol. The involvement of both polymorphisms as independent factors in determining the levels of glucose and HDL-cholesterol was confirmed by multiple regression analysis (β = 0.19 ±0.09, p = 0.03 and β= 0.22 ± 0.10, p = 0.03, respectively). Our findings suggest that the HSD11B1SNPs studied may indirectly influence glucose and HDL-cholesterol metabolism in women, possibly through down-regulation of the HSD11B1 gene by estrogen.
authors.affiliation: Departamento de Genética , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Luciane Viater
authors.initials: LV
authors.lastname: Turek
authors.affiliation: Departmento de Educação Física , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Neiva
authors.initials: N
authors.lastname: Leite
authors.affiliation: Departamento de Genética , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Ricardo Lehtonen
authors.initials: RL
authors.lastname: Rodrigues Souza
authors.affiliation: Departamento de Genética , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Jovana Karoline
authors.initials: JK
authors.lastname: Lima
authors.affiliation: Departmento de Educação Física , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Gerusa Eisfeld
authors.initials: GE
authors.lastname: Milano
authors.affiliation: Departmento de Educação Física , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Luciana da Silva
authors.initials: Lda S
authors.lastname: Timossi
authors.affiliation: Departmento de Educação Física , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Ana Claudia Vecchi
authors.initials: AC
authors.lastname: Osiecki
authors.affiliation: Departmento de Educação Física , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Raul
authors.initials: R
authors.lastname: Osiecki
authors.affiliation: Departamento de Genética , Universidade Federal de Paraná , Curitiba, PR , Brazil .
authors.forename: Lupe Furtado
authors.initials: LF
authors.lastname: Alle
keywords: HSD11B1 gene; men; metabolic syndrome; metabolism; women