title: [Diagnostic value of C-reactive protein and procalcitonin for bacterial infection in acute exacerbations of chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To investigate the value of C-reactive protein (CRP) and procalcitonin (PCT) in diagnosis of the bacterial infection in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) patients by detecting the change of CRP and PCT.
  
  
  METHODS
  A total of 369 AECOPD patients were divided into infective group and non-infective group. The values of CRP, PCT, WBC, N and ESR were tested and compared before and after treatment in each group.
  
  
  RESULTS
  Before treatment, the levels of CRP, PCT, WBC, and N in the infective group were significantly higher than that in the non-infective group (P<0.05 or P<0.01), while there was no significant difference in ESR level between the 2 groups (P>0.05). In the infective group, the levels of CRP, PCT, WBC, N and ESR after the treatment were much lower than those before treatment (P<0.05). After treatment, the levels of CRP, PCT, WBC, and N in the infective group were significantly higher compared with that in the non-infective group (P<0.05), while there was no significant difference of ESR level between the 2 groups (P>0.05). There was a positive relationship between PCT and CRP, ESR and WBC (r=0.46, 0.38, 0.20; P<0.05), CRP and WBC as well as N and ESR (r=0.56, 0.43, 0.30; P<0.05).
  
  
  CONCLUSIONS
  It is a sensitive method for diagnosis and treatment of the bacterial infection in AECOPD patients through the combination of CRP with PCT and also for evaluation of the prognosis of patients with AECOPD.
authors.affiliation: Department of Respiratory Medicine, Xiangdong Affiliated Hospital of Hunan Normal University, Zhuzhou Hunan 412200,China 1144185040@qq.com.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhou
mesh_terms: D001424:Bacterial Infections / Q000150:complications / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000032:analysis*; D015740:Calcitonin Gene-Related Peptide; D006801:Humans; D011379:Prognosis; D011498:Protein Precursors / Q000032:analysis*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000382:microbiology
chemical_list: C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide