title: Is impaired kidney function an independent predictor of the risk of myocardial infarction in HIV-infected individuals?
abstract: We examined whether impaired kidney function is an independent risk factor for myocardial infarction in HIV-infected individuals without pre-existing coronary artery disease. The odds ratio for impaired kidney function fell from 1.22 (95% confidence interval 0.90-1.66) to 0.99 (95% confidence interval 0.69-1.41) after adjustment for cardiovascular risk factors and HIV-related parameters, with hypertension, high-density lipoprotein cholesterol, smoking and the CD4 T-cell nadir as most influential confounders. In this setting, no association was found between impaired kidney function and the risk of myocardial infarction.
authors.affiliation: aINSERM, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique bSorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris cHôpitaux Universitaires de Strasbourg, Le Trait D'Union, centre de soins de l'infection par le VIH, Strasbourg dAPHP, Hôtel Dieu, Unité d'immuno-infectiologie eCentre Médical de l'Institut Pasteur fAPHP, Hôpital Pitié-Salpêtrière, service de médecine interne I, Paris gHospices Civils de Lyon, Hôpital de la Croix Rousse, service des maladies infectieuses et tropicales hINSERM, U 1052, Lyon iAPHP, Hôpital Saint-Antoine, service de cardiologie jINSERM, UMR_S 938 kSorbonne Universités, UPMC Univ Paris 06, UMR_S 938, Paris, France. *The full list of FHDH-ANRS CO4 investigators can be found at http://http://www.ccde.fr.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Lang
authors.forename: Murielle
authors.initials: M
authors.lastname: Mary-Krause
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Partisani
authors.forename: Jacques
authors.initials: J
authors.lastname: Gilquin
authors.forename: Anne
authors.initials: A
authors.lastname: Simon
authors.forename: Laurent
authors.initials: L
authors.lastname: Cotte
authors.forename: Franck
authors.initials: F
authors.lastname: Boccara
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
mesh_terms: D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D051437:Renal Insufficiency / Q000150:complications*; D018570:Risk Assessment; D012307:Risk Factors