title: Management of hypertensive disorders in pregnancy.
abstract: Hypertensive disorders are the most common medical complication of pregnancy, with an incidence of 5-10%, and a common cause of maternal mortality in the USA. Incidence of pre-eclampsia has increased by 25% in the past two decades. In addition to being among the lethal triad, there are likely up to 100 other women who experience 'near miss' significant maternal morbidity that stops short of death for every pre-eclampsia-related mortality. The purpose of this review is to present the new task force statement and novel definitions, as well as management approaches to each of the hypertensive disorders in pregnancy. The increased understanding of the pathophysiology of hypertension in pregnancy, as well as advances in medical therapy to minimize risks of fetal toxicity and teratogenicity, will improve our ability to prevent and treat hypertension in pregnancy. Fetal programming and fetal origins of adult disease theories extrapolate the benefit of such therapy to future generations.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology & Reproductive Sciences, The University of Texas Medical School at Houston, 6431 Fannin, Suite 3.430, Houston, TX 77030, USA.
authors.forename: Hind N
authors.initials: HN
authors.lastname: Moussa
authors.forename: Sara E
authors.initials: SE
authors.lastname: Arian
authors.forename: Baha M
authors.initials: BM
authors.lastname: Sibai
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D005260:Female; D005323:Fetal Monitoring; D017359:HELLP Syndrome / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis* / Q000188:drug therapy* / Q000628:therapy; D015994:Incidence; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D012720:Severity of Illness Index
chemical_list: D000959:Antihypertensive Agents
keywords: HELLP syndrome; eclampsia; hypertension; pre-eclampsia; pregnancy; severe features