title: Efficacy and safety of fixed-dose losartan/hydrochlorothiazide/amlodipine combination versus losartan/hydrochlorothiazide combination in Japanese patients with essential hypertension.
abstract: Japanese patients with uncontrolled essential hypertension received single-blind losartan 50 mg/hydrochlorothiazide 12.5 mg (L50/H12.5) for 8 weeks. Patients whose blood pressure (BP) remained uncontrolled were randomized double-blind to fixed-dose losartan 50 mg/hydrochlorothiazide 12.5 mg/amlodipine 5 mg (L50/H12.5/A5) or L50/H12.5 for 8 weeks followed by open-label L50/H12.5/A5 for 44 weeks. Adverse events were assessed. After 8 weeks, diastolic and systolic BP were reduced significantly more with L50/H12.5/A5 versus L50/H12.5 (both p < 0.001). Mean changes in diastolic and systolic BP were sustained for 44 weeks. L50/H12.5/A5 was well-tolerated and improved BP significantly versus L50/H12.5 in Japanese patients with uncontrolled essential hypertension.
authors.affiliation: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine , Osaka , Japan .
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsuchihashi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Numaguchi
authors.forename: Chisato
authors.initials: C
authors.lastname: Nishida
authors.forename: Hiroya
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Shirakawa
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Azuma
authors.forename: Kenji P
authors.initials: KP
authors.lastname: Fujita
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects*; D004338:Drug Combinations; D016903:Drug Monitoring / Q000379:methods; D000075222:Essential Hypertension; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology; D007564:Japan; D019808:Losartan / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D006852:Hydrochlorothiazide; D017311:Amlodipine; D019808:Losartan
keywords: Amlodipine; Japanese; hydrochlorothiazide; losartan