title: Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
abstract: We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] ( and ) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles and , dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes and were highly active towards A2780 human ovarian cancer cells (IC(50) 0.17 and 2.50 μM, respectively) and the encapsulated complexes, as and nanoparticles, were less potent (IC(50) 6.69 μM and 117.5 μM, respectively), but more selective towards cancer cells compared to normal cells.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK. N.Barry@warwick.ac.uk P.J.Sadler@warwick.ac.uk.
authors.forename: Nicolas P E
authors.initials: NP
authors.lastname: Barry
authors.forename: Anaïs
authors.initials: A
authors.lastname: Pitto-Barry
authors.forename: Isolda
authors.initials: I
authors.lastname: Romero-Canelón
authors.forename: Johanna
authors.initials: J
authors.lastname: Tran
authors.forename: Joan J
authors.initials: JJ
authors.lastname: Soldevila-Barreda
authors.forename: Ian
authors.initials: I
authors.lastname: Hands-Portman
authors.forename: Corinne J
authors.initials: CJ
authors.lastname: Smith
authors.forename: Nigel
authors.initials: N
authors.lastname: Kirby
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Dove
authors.forename: Rachel K
authors.initials: RK
authors.lastname: O'Reilly
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001880:Boranes / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D008823:Micelles; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009992:Osmium / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011108:Polymers / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001880:Boranes; D008823:Micelles; D009942:Organometallic Compounds; D011108:Polymers; D009992:Osmium; D012428:Ruthenium