title: Lack of association between LEPR Q223R polymorphisms and cancer susceptibility: evidence from a meta-analysis.
abstract: OBJECTIVE
  The results from the published studies on the association between LEPR genetic polymorphisms and cancer risk are conflicting. The common LEPR Q223R genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancer. However, the association between LEPR Q223R genetic polymorphism and cancer risk remains inconclusive.
  
  
  METHODS
  To better understand the role of LEPR Q223R genetic polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 9139 cases and 11282 controls.
  
  
  RESULTS
  Overall, the LEPR Q223R genetic polymorphism did not significantly affect the risk of cancer. In the stratified analysis, there was no significant association of LEPR Q223R variant with breast cancer, colorectal cancer and non-Hodgkin's lymphoma (NHL) under any models. Moreover, significantly increased risks were found in Asian and African in all genetic models tested. When stratified by study design, no significantly increased susceptibility to cancer was found among any studies. No significantly differences in sample size in cases were found among genotypes.
  
  
  CONCLUSIONS
  These findings suggested lack of association between LEPR Q223R polymorphisms and cancer susceptibility, but the LEPR Q223R genetic polymorphism may increase the susceptibility to cancers in Asian and African individuals. Large, well designed epidemiological studies are needed to validate our findings.
authors.affiliation: Department of Orthopedics , Shanghai Tenth People's Hospital , Tongji University, School of Medicine , Shanghai, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.forename: Run
authors.initials: R
authors.lastname: Liu
authors.forename: Yunji
authors.initials: Y
authors.lastname: Yang
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Changjia
authors.initials: C
authors.lastname: Huang
authors.forename: Hexi
authors.initials: H
authors.lastname: Shu
authors.forename: Jinpeng
authors.initials: J
authors.lastname: Gong
authors.forename: Ming
authors.initials: M
authors.lastname: Cai
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D054411:Receptors, Leptin / Q000235:genetics*
chemical_list: C515448:LEPR protein, human; D054411:Receptors, Leptin