title: Measuring the impact of cognitive and psychosocial interventions in persons with mild cognitive impairment with a randomized single-blind controlled trial: rationale and design of the MEMO+ study.
abstract: BACKGROUND
  Several studies have suggested that cognitive training is a potentially effective way to improve cognition and postpone cognitive decline in older adults with mild cognitive impairment (MCI). The MEMO+ study is a randomized, controlled, single-blind trial designed to test the efficacy, specificity, and long-term effect of a cognitive training intervention and a psychosocial intervention in persons with MCI.
  
  
  METHODS
  One hundred and sixty-two participants with MCI will be recruited. They will be randomized into three groups: cognitive training, psychosocial intervention, and no-contact. Each intervention will last for eight weeks (one session per week) and a booster training session will be provided three months after the end of the intervention. Various proximal and distal outcomes will be measured at pre-intervention as well as at one week, three months, and six months post-training. Proximal outcomes include memory and psychological health measures. Distal outcomes focus on self-rated functioning in complex daily activities and strategies used in daily life to enhance function. Socio-demographic factors (age, gender, and education), general cognition, personality traits, engagement in activities, and self-efficacy will be used as moderators. Enrolment began in April 2012 and will be completed by December 2014.
  
  
  CONCLUSIONS
  This study is likely to have a significant impact on the well-being of persons with MCI by contributing to the development of adapted and scientifically supported cognitive and psychosocial interventions.
authors.affiliation: Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bier
authors.affiliation: Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Grenier
authors.affiliation: McGill Health Center,Montréal,Québec H3G 1A4,Canada.
authors.forename: Catherine
authors.initials: C
authors.lastname: Brodeur
authors.affiliation: Faculty of Medicine,McGill University,Montréal,Québec H3G 1Y6,Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Gilbert
authors.affiliation: Institut Universitaire en santé Mentale de Québec,Québec G1J 2G3,Canada.
authors.forename: Carol
authors.initials: C
authors.lastname: Hudon
authors.affiliation: Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
authors.forename: Émilie
authors.initials: É
authors.lastname: Lepage
authors.affiliation: Programme de Psychologie,Université Laval,Québec G1V 0A6,Canada.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Ouellet
authors.affiliation: Programme de Gérontologie,Université de Sherbrooke,Sherbrooke,Québec J1K 2R1,Canada.
authors.forename: Chantal
authors.initials: C
authors.lastname: Viscogliosi
authors.affiliation: Centre de Recherche,Institut Universitaire de Gériatrie de Montréal,Montréal,Québec H3W 1W4,Canada.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Belleville
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D002170:Canada; D003071:Cognition; D060825:Cognitive Dysfunction / Q000534:rehabilitation*; D003704:Dementia / Q000534:rehabilitation*; D004493:Education; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D063868:Patient Outcome Assessment; D012107:Research Design; D020377:Self Efficacy; D016037:Single-Blind Method
keywords: neuropsychological testing