title: On naivety of T cells in inflammatory bowel disease: a review.
abstract: : Little is known about different phases of T-cell maturation in gut mucosa. Based on current knowledge about the migratory pathways of naive and memory T cells, it is believed that access to peripheral, nonlymphoid tissues is restricted to memory T cells. Surprisingly, there is increasing evidence of high numbers of naive T cells in the chronically inflamed gut tissue of patients with inflammatory bowel disease. This could partially be explained by new formation of ectopic lymphoid organs. Ongoing recruitment of naive T cells at inflammatory sites might play a role in the immunopathogenesis of inflammatory bowel disease.
authors.affiliation: *Department of Gastroenterology and Hepatology, Rijnstate Hospital, Arnhem, the Netherlands; †Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands; and ‡Department of Microbiology and Immunology, Rijnstate Hospital, Arnhem, the Netherlands.
authors.forename: Carolijn
authors.initials: C
authors.lastname: Smids
authors.forename: Carmen S
authors.initials: CS
authors.lastname: Horjus Talabur Horje
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Wahab
authors.forename: Marcel J M
authors.initials: MJ
authors.lastname: Groenen
authors.forename: Sabine
authors.initials: S
authors.lastname: Middendorp
authors.forename: Ellen G
authors.initials: EG
authors.lastname: van Lochem
mesh_terms: D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*