title: A comparison of concurrent chemoradiotherapy and radiotherapy in Chinese patients with locally advanced cervical carcinoma: a multi-center study.
abstract: BACKGROUND
  We investigated the efficacy of concurrent chemoradiotherapy (CCRT) over radiotherapy (RT) in Chinese patients with locally advanced cervical carcinoma.
  
  
  METHODS
  Between January 2005 and January 2008, 192 patients with squamous cell carcinoma of the cervix were included in the study: 96 in arm A (CCRT with 20 mg/m2 cisplatin for 5 days) and 96 in arm B (RT). The overall response rate was the primary endpoint. The secondary endpoints included overall survival, progression-free survival, and toxicity.
  
  
  RESULTS
  The 5-year overall response rate was 67% and 53% for the CCRT and RT arms, respectively, and the difference was statistically significant, while the median overall survival was 68 months (range 3-85 months) and 61 months (range 4-83 months), respectively (P = 0.009). In addition, the median progression-free survival for CCRT was 62 months (range 3-83 months), whereas it was 51 months (range 4-81 months) for the RT arm (P = 0.025). The toxicity profile, both acute and late, was comparable in both arms.
  
  
  CONCLUSIONS
  In summary, we demonstrate that CCRT was effective and better tolerated than RT alone in Chinese patients with locally advanced cervical carcinoma.
  
  
  BACKGROUND
  Chinese Clinical Trials Register: ChiCTR-TRC-13003979.
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Li
authors.forename: Shuyan
authors.initials: S
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Gynaecology and Obstetrics, Fourth Affiliated Hospital of Harbin Medical University, No,37 Yiyuan Street, Nangang District, Harbin, Heilongjiang Province 150001, China. hanshiyu0451@163.com.
authors.forename: Shiyu
authors.initials: S
authors.lastname: Han
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D044466:Asian People; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000628:therapy*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000628:therapy*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin