title: Adenocarcinoma at the gastroesophageal junction.
abstract: The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the clinical differences between carcinomas arising slightly above, slightly below, and within the gastroesophageal junction (GEJ); information provided by biopsies; information provided by resection specimens following neoadjuvant therapy; histologic differences existing between carcinomas arising slightly above, slightly below, and within the GEJ; differences provided by immunohistochemistry in these tumors; information given by endoscopic mucosal resection specimens; the role of esophageal pyloric gland adenomas as precursors of adenocarcinomas in the region of the cardia; the role of pancreatic metaplasia; Her2 immunoreactivity to make distinctions in the site of origin; and intestinal metaplasia limited to the cardia as a precursor of adenocarcinoma.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, Toronto, Canada.
authors.forename: Sahar
authors.initials: S
authors.lastname: Al-Haddad
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Chang
authors.forename: Gert
authors.initials: G
authors.lastname: De Hertogh
authors.forename: Andrea
authors.initials: A
authors.lastname: Grin
authors.forename: Rupert
authors.initials: R
authors.lastname: Langer
authors.forename: Xavier
authors.initials: X
authors.lastname: Sagaert
authors.forename: Marianna
authors.initials: M
authors.lastname: Salemme
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Streutker
authors.forename: Geneviève
authors.initials: G
authors.lastname: Soucy
authors.forename: Monika
authors.initials: M
authors.lastname: Tripathi
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Upton
authors.forename: Michael
authors.initials: M
authors.lastname: Vieth
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villanacci
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000628:therapy; D000818:Animals; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000628:therapy; D004943:Esophagogastric Junction / Q000473:pathology*; D004945:Esophagoscopy / Q000379:methods; D006801:Humans; D010297:Paris; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000628:therapy
keywords: Her2; OESO; gastroesophageal junction; immunohistochemistry; intestinal metaplasia; neoadjuvant; pyloric gland adenoma