title: The potential of microRNAs in personalized medicine against cancers.
abstract: MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and resistance to chemo/radiotherapies. Thus, microRNAs constitute appealing targets for novel anticancer therapeutic strategies aimed at restoring their expression or function. As microRNAs are present in a variety of human cancer types, microRNA profiles can be used as tumor-specific signatures to detect various cancers (diagnosis), to predict their outcome (prognosis), and to monitor their treatment (theranosis). In this review, we present the different aspects of microRNA biology that make them remarkable molecules in the emerging field of personalized medicine against cancers and provide several examples of their industrial exploitation.
authors.affiliation: Université Montpellier 1, 5 Bd Henri IV, 34967 Montpellier Cedex 2, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Saumet
authors.affiliation: Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.
authors.forename: Anthony
authors.initials: A
authors.lastname: Mathelier
authors.affiliation: Université Montpellier 1, 5 Bd Henri IV, 34967 Montpellier Cedex 2, France ; Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4 ; Institut de Génétique Moléculaire de Montpellier, UMR 5535 CNRS, 1919 route de Mende, 34293 Montpellier Cedex 5, France ; Université Montpellier 2, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Charles-Henri
authors.initials: CH
authors.lastname: Lecellier
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D055808:Drug Discovery; D006801:Humans; D051379:Mice; D035683:MicroRNAs; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D057285:Precision Medicine
chemical_list: D035683:MicroRNAs