title: Melanoma vaccines: mixed past, promising future.
abstract: Cancer vaccines were one of the earliest forms of immunotherapy to be investigated. Past attempts to vaccinate against cancer, including melanoma, have mixed results, showing the complexity of what was believed to be a simple concept. However, several recent successes and the combination of improved knowledge of tumor immunology and the advent of new immunomodulators make vaccination a promising strategy for the future.
authors.affiliation: John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
authors.forename: Junko
authors.initials: J
authors.lastname: Ozao-Choy
authors.affiliation: John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.
authors.forename: Delphine J
authors.initials: DJ
authors.lastname: Lee
authors.affiliation: John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA. Electronic address: mark.faries@jwci.org.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Faries
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology / Q000627:therapeutic use*; D005544:Forecasting; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods; D008545:Melanoma / Q000188:drug therapy* / Q000276:immunology; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000276:immunology; D022223:Vaccines, Subunit / Q000276:immunology / Q000627:therapeutic use
chemical_list: D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D005732:Gangliosides; D007155:Immunologic Factors; D022223:Vaccines, Subunit
keywords: Adjuvant; Immunomodulator; Immunotherapy; Melanoma; Vaccine