title: Synapse rearrangements upon learning: from divergent-sparse connectivity to dedicated sub-circuits.
abstract: Learning can involve formation of new synapses and loss of synapses, providing memory traces of learned skills. Recent findings suggest that these synapse rearrangements reflect assembly of task-related sub-circuits from initially broadly distributed and sparse connectivity in the brain. These local circuit remodeling processes involve rapid emergence of synapses upon learning, followed by protracted validation involving strengthening of some new synapses, and selective elimination of others. The timing of these consolidation processes can vary. Here, we review these findings, focusing on how molecular/cellular mechanisms of synapse assembly, strengthening, and elimination might interface with circuit/system mechanisms of learning and memory consolidation. An integrated understanding of these learning-related processes should provide a better basis to elucidate how experience, genetic background, and disease influence brain function.
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland. Electronic address: pico.caroni@fmi.chi.
authors.forename: Pico
authors.initials: P
authors.lastname: Caroni
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Ananya
authors.initials: A
authors.lastname: Chowdhury
authors.affiliation: Friedrich Miescher Institut, Basel, Switzerland.
authors.forename: Maria
authors.initials: M
authors.lastname: Lahr
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D013569:Synapses / Q000378:metabolism / Q000502:physiology*
keywords: adult plasticity; connectomics; learning; memory consolidation; synapse elimination; synapse formation