title: Syntheses of new rare earth complexes with carboxymethylated polysaccharides and evaluation of their in vitro antifungal activities.
abstract: In the present paper, La, Eu and Yb were selected to represent light, middle and heavy rare earths to form complexes with polysaccharides through chelating coordination of carboxyl groups, which were added into polysaccharide chains by means of carboxymethylation. Their antifungal activities against plant pathogenic fungi were evaluated using growth rate method. These rare earth complexes exhibited various antifungal activities against the tested fungi, depending on rare earth elements, polysaccharide types and fungal species. Among these three metal elements (i.e. La, Eu and Yb), Yb formed the complexes with the most effective antifungal properties. Furthermore, the results showed that ligands of carboxymethylated polysaccharides played a key role in promoting cytotoxicity of the rare earth complexes. Carboxymethylated Ganoderma applanatum polysaccharide (CGAP) was found to be the most effective ligand to form complexes with antifungal activities, followed by carboxymethylated lentinan (CLNT) and carboxymethylated Momordica charantia polysaccharide (CMCP).
authors.affiliation: College of Chemical and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, PR, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Sun
authors.affiliation: College of Chemical and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, PR, China.
authors.forename: Xiaozhe
authors.initials: X
authors.lastname: Jin
authors.affiliation: College of Chemical and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, PR, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.affiliation: College of Chemical and Pharmaceutical Sciences, Qingdao Agricultural University, Qingdao 266109, PR, China. Electronic address: jpwang@qau.edu.cn.
authors.forename: Jinping
authors.initials: J
authors.lastname: Wang
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008674:Metals, Rare Earth / Q000138:chemical synthesis* / Q000494:pharmacology; D008745:Methylation; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology; D020940:Reishi / Q000302:isolation & purification
chemical_list: D000935:Antifungal Agents; D008674:Metals, Rare Earth; D011134:Polysaccharides
keywords: Antifungal effect; Carboxymethylation; Polysaccharide; Rare earth complexes