title: Role of a medical device for intra-vaginal use in improving the quality of the colposcopic examination and the anatomical/pathological reading of the cytological test and biopsy.
abstract: To evaluate the efficacy of a vaginal suppository in overcoming unsatisfactory colposcopy and/or possible change in terms of diagnosis in women who have had abnormal cervical cytology, 98 females were enrolled and treated for 10 days with Kramegin®, a vaginal product in tablets containing Lactobacillus acidophilus, lactic acid and Krameria triandra extract. Seventy-eight of 98 females completed the study. Seventy-fife of 78 volunteers served for the statistical analysis. According to the results got, diagnoses were modified in almost 62% of cases; cervical conization was reduced in 58% of cases; regression for HSIL (to LSIL) was 35% higher than expected; need of follow-up decreased by 36% and treatment was well tolerated in about 96% of cases. Use of Kramegin® before colposcopy can be considered a good tool to increase the possibility of turning unsatisfactory colposcopy into satisfactory and seems to indicate a possible role in reducing cervical lesion progression. Deeper clinical investigations are mandatory to confirm this possible result.
authors.affiliation: Scientific Dept., Velleja Research, Milano, Italia. f.dipierro@vellejaresearch.com.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Pierro
authors.forename: Gaetana
authors.initials: G
authors.lastname: Di Paola
authors.forename: Paolo
authors.initials: P
authors.lastname: Risso
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods / Q000592:standards*; D003127:Colposcopy / Q000379:methods / Q000592:standards*; D004867:Equipment Design; D005260:Female; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011247:Pregnancy; D058996:Quality Improvement; D013488:Suppositories; D014621:Vagina; D014627:Vaginitis / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D013488:Suppositories