title: Cytotoxic and anti-inflammatory tirucallane triterpenoids from Dysoxylum binectariferum.
abstract: Four new tirucallane triterpenoids 1-4 along with two known compounds 5 and 6 were isolated from the stem bark of Dysoxylum binectariferum. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for anti-inflammatory and cytotoxic potential against eight tumor cell lines. Compounds 1-6 exhibited significant selective inhibition of Cox-1 and selectively significant cytotoxic against five tumor cell lines (A-549, HCT15, HepG2, SGC-7901 and SK-MEL-2), especially against HepG2 cell lines with IC₅₀ value of 7.5-9.5 μM.
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China. Electronic address: hujiang@ustc.edu.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of Pharmacy, 455 Hospital of People's Liberation Army, Shanghai 200052, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.affiliation: College of Physics and Electronic Engineering, Qujing Normal University, Qujing 655011, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China.
authors.forename: Benshou
authors.initials: B
authors.lastname: Yang
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Mao
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China.
authors.forename: YongMao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: College of Biological Resources and Environment Science, Qujing Normal University, Qujing 655011, Yunnan, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D029582:Meliaceae / Q000737:chemistry*; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D016861:Cyclooxygenase Inhibitors; D014315:Triterpenes; C514393:tirucallane
keywords: Anti-inflammatory; Cytotoxicity; Dysoxylum binectariferum; Meliaceae; Tirucallane triterpenoids