title: An in vivo three-dimensional magnetic resonance imaging-based averaged brain collection of the neonatal piglet (Sus scrofa).
abstract: Due to the fact that morphology and perinatal growth of the piglet brain is similar to humans, use of the piglet as a translational animal model for neurodevelopmental studies is increasing. Magnetic resonance imaging (MRI) can be a powerful tool to study neurodevelopment in piglets, but many of the MRI resources have been produced for adult humans. Here, we present an average in vivo MRI-based atlas specific for the 4-week-old piglet. In addition, we have developed probabilistic tissue classification maps. These tools can be used with brain mapping software packages (e.g. SPM and FSL) to aid in voxel-based morphometry and image analysis techniques. The atlas enables efficient study of neurodevelopment in a highly tractable translational animal with brain growth and development similar to humans.
authors.affiliation: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Conrad
authors.affiliation: Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
authors.forename: Bradley P
authors.initials: BP
authors.lastname: Sutton
authors.affiliation: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
authors.forename: Ryan N
authors.initials: RN
authors.lastname: Dilger
authors.affiliation: Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Integrative Immunology and Behavior Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America.
authors.forename: Rodney W
authors.initials: RW
authors.lastname: Johnson
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology* / Q000254:growth & development*; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D012984:Software; D034421:Sus scrofa