title: Electrophysiological registration of phonological perception in the subthalamic nucleus of patients with Parkinson's Disease.
abstract: Phonological processing is usually associated with the activation of cortical areas, especially in the left cerebral hemisphere. This study examined if phonologically elicited evoked potentials can be recorded directly from the subthalamic nucleus in patients with Parkinson's Disease (PD). Seven PD patients who had undergone implantation of deep brain electrodes for the stimulation of the subthalamic nucleus were included. Local field potentials were recorded in a pre-attentive auditory phonological task, an attentive auditory phonological discrimination task, and a word recognition task. Auditory evoked potentials related to phonological, but not lexical processing, could be demonstrated in the subthalamic nucleus for all three tasks. Only minor changes were found after levodopa administration. This study demonstrates that the subthalamic nucleus is involved in early phonological perception, which puts the subthalamic nucleus in a position to modify phonological perception in a larger cortico-subcortical network.
authors.affiliation: Department of Speech, Language and Hearing Sciences, Ghent University, Ghent, Belgium; Department of Neurology, Ghent University Hospital, Ghent, Belgium. Electronic address: miet.deletter@ugent.be.
authors.forename: M
authors.initials: M
authors.lastname: De Letter
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Aerts
authors.affiliation: Department of Speech, Language and Hearing Sciences, Ghent University, Ghent, Belgium; Universidade Veiga de Almeida, Rio de Janeiro, Brazil.
authors.forename: J
authors.initials: J
authors.lastname: Van Borsel
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Vanhoutte
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: De Taeye
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Raedt
authors.affiliation: Medical Imaging and Signal Processing Group, Department of Electronics and Information Systems, Ghent University, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: van Mierlo
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Boon
authors.affiliation: Department of Neurosurgery, Ghent University Hospital, Ghent, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Van Roost
authors.affiliation: Department of Neurology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Santens
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D046690:Deep Brain Stimulation; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D013067:Speech Perception / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa
keywords: Dopamine; Parkinson; Perception; Phonology; Subthalamic nucleus