title: The neuroprotective role of vesicular monoamine transporter 2 in neurodegenerative diseases.
abstract: Neuropharmacological relation of religious belief supports the role of dopaminergic activation as the leading neurochemical feature. However, vesicular monoamine transporter-2 (VMAT-2) has been shown to be responsible for removing of neurotransmitters such as dopamine that may secondarily lead to a neuroprotective activity by different neurodegeneration models. Moreover, there are interesting data showing that VMAT-2 may play an important role during religious belief and experience. In the light of these findings, we aimed to review the preclinical and clinical neuroprotective data of Vesicular monoamine transporter (VMAT-2) in different neurodegenerative and neuropsychiatric diseases. In respect of rapidly increasing evidences about the neurobiological and neuroimaging correlates of religious belief, we hypothesized that there is a link between belief and neuroprotection.
authors.forename: Burak
authors.initials: B
authors.lastname: Yulug
authors.forename: Lutfu
authors.initials: L
authors.lastname: Hanoglu
authors.affiliation: Istanbul-Medipol University, Faculty of Medicine, Deparment of Neurology, Istanbul, Turkey. burakyulug@gmail.com.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kilic
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010300:Parkinson Disease / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D012068:Religion and Medicine; D013140:Spiritualism; D050493:Vesicular Monoamine Transport Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D050493:Vesicular Monoamine Transport Proteins; D004298:Dopamine