title: Tenoxicam-kollicoat IR binary systems: physicochemical and biological evaluation.
abstract: Tenoxicam (TNX) binary systems in Kollicoat IR (KL) matrix were prepared in different drug: polymer ratios using kneading and spray-drying method. The prepared binary systems were characterized for drug dissolution rate, differential scanning calorimetry (DSC), IR spectroscopy and x-ray diffractometry. The results showed that the drug dissolution rate was remarkably enhanced by incorporating it in the KL matrix either by kneading or spray-drying, and the dissolution rate was increased by decreasing the drug weight ratio. The DSc and x-ray studies revealed the presence of TNX in less crystalline or amorphous state in its-KL binary systems. Moreover, the spray-dried TNX-KL system in 1:4 ratio, that exhibited the faster dissolution rate, was formulated in oral disintegrating tablets (ODTs). The data indicated that a fast disintegration and higher drug dissolution rate was achieved in case of the ODTs containing the spray-dried form compared to the ODTS containing untreated drug or the commercial tablet (Epicotil). Also, the drug exhibited significantly (p < 0.01) faster onset of the anti-inflammatory analgesic activities in case of the ODTs containing the spray-dried form, that was superior to that observed with both the commercial tablet product and the ODTS containing untreated drug.
authors.forename: Mohamed Abbas
authors.initials: MA
authors.lastname: Ibrahim
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D002152:Calorimetry, Differential Scanning; D005260:Female; D008297:Male; D064347:Microscopy, Electrochemical, Scanning; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011145:Polyvinyls / Q000737:chemistry*; D051381:Rats; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; C519734:Kollicoat IR; D011145:Polyvinyls; D010894:Piroxicam; C032801:tenoxicam