title: Integration of genomic information in the clinical management of HCC.
abstract: Molecular profiling of hepatocellular carcinoma (HCC) is enabling the advancement of novel approaches to disease diagnosis and management. Accurate prognosis prediction in HCC is specially critical. Clinical staging systems for HCC support clinical decision-making (e.g., BCLC algorithm) might be complemented by molecular-based information in the near future. Molecular signatures derived from tumour and non-tumour samples are associated with patient recurrence an outcome. Single nucleotide polymorphisms have been linked with HCC development. Next generation sequencing studies have brought to light the genomic diversity of this disease. Gens recurrently altered in HCC and susceptible to be targeted belong to signalling pathways including telomere maintenance, cell cycle, chromatin remodelling, Wnt/beta-catenin, RAS/RAF/MAPK and PI3K/AKT/mTOR pathways. Oncogenic loops are unknown but might include some of the already discovered aberrations. Despite the intratumoral heterogeneity observed in HCC tumours, studies including large number of samples can identify key genetic drivers and contribute to the development of novel treatments and a personalized medicine.
authors.affiliation: HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group (BCLC), Liver Unit, IDIBAPS, Hospital Clínic, CIBERehd, University of Barcelona, C/Rosselló 153, 08036 Barcelona, Catalonia, Spain. Electronic address: imartinez@clinic.ub.es.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Quetglas
authors.affiliation: HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group (BCLC), Liver Unit, IDIBAPS, Hospital Clínic, CIBERehd, University of Barcelona, C/Rosselló 153, 08036 Barcelona, Catalonia, Spain. Electronic address: amoeini@clinic.ub.es.
authors.forename: Agrin
authors.initials: A
authors.lastname: Moeini
authors.affiliation: HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group (BCLC), Liver Unit, IDIBAPS, Hospital Clínic, CIBERehd, University of Barcelona, C/Rosselló 153, 08036 Barcelona, Catalonia, Spain. Electronic address: rpinyol@clinic.cat.
authors.forename: Roser
authors.initials: R
authors.lastname: Pinyol
authors.affiliation: HCC Translational Research Laboratory, Barcelona Clinic Liver Cancer Group (BCLC), Liver Unit, IDIBAPS, Hospital Clínic, CIBERehd, University of Barcelona, C/Rosselló 153, 08036 Barcelona, Catalonia, Spain; Mount Sinai Liver Cancer Program, Icahn School of Medicine at Mount Sinai, Mount Sinai School of Medicine, New York, NY, USA; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. Electronic address: jmllovet@clinic.ub.es.
authors.forename: Josep M
authors.initials: JM
authors.lastname: Llovet
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D058990:Molecular Targeted Therapy
keywords: Biomarker; Gene signatures; Hepatocellular carcinoma; Molecular profiling; Targeted therapies