title: Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during, and after cardiopulmonary bypass.
abstract: Because of its similarity to humans in important respects, sheep (Ovis aries) are a common animal model for translational research in cardiovascular surgery. However, some unique aspects of sheep anatomy and physiology present challenges to its use in these complicated experiments. In this review, we discuss relevant anatomy and physiology of sheep and discuss management before, during, and after procedures requiring cardiopulmonary bypass to provide a concise source of information for veterinarians, technicians, and researchers developing and implementing protocols with this model.
authors.affiliation: Department of Comparative Medicine, University of Rochester Medical Center, Rochester, New York, USA. louis_divincenti@urmc.rochester.edu.
authors.forename: Louis
authors.initials: L
authors.lastname: DiVincenti
authors.affiliation: Division of Laboratory Animal Medicine, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Westcott
authors.affiliation: Department of Surgery, University of Rochester Medical Center, Rochester, New York, USA.
authors.forename: Candice
authors.initials: C
authors.lastname: Lee
mesh_terms: D000758:Anesthesia; D000818:Animals; D002315:Cardiopulmonary Bypass / Q000379:methods*; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D019990:Perioperative Care; D011300:Preoperative Care; D034561:Sheep, Domestic