title: Serum YKL-40 levels as a prognostic factor in patients with intracerebral hemorrhage.
abstract: OBJECTIVE
  This study aimed to investigate the relationship between serum YKL-40 concentrations and 3-month clinical outcomes in patients with intracerebral hemorrhage.
  
  
  METHODS
  In 172 consecutive patients and 172 sex- and age-matched healthy controls, serum YKL-40 concentrations were measured with an enzyme-linked immunoassay. The prognostic value of YKL-40 concentrations for 3-month mortality and functional outcome was assessed. An unfavorable outcome was defined as a score above 2 on the modified Rankin Scale.
  
  
  RESULTS
  Serum concentrations of YKL-40 were markedly higher in all patients than in healthy controls, and were correlated positively with National Institute of Health Stroke Scale scores and plasma C-reactive protein levels. YKL-40 was identified as an independent predictor of 3-month mortality and unfavorable outcome and its area under receiver operating characteristic curve was similar to the National Institute of Health Stroke Scale scores. However, it did not improve the prognostic predictive performance of National Institute of Health Stroke Scale score.
  
  
  CONCLUSIONS
  YKL-40 is associated with inflammation and severity of intracerebral hemorrhage, and may independently predict long-term clinical outcomes of intracerebral hemorrhage.
authors.affiliation: Department of Neurology, Taizhou First People's Hospital, Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China.
authors.forename: Yi-Xiang
authors.initials: YX
authors.lastname: Jiang
authors.affiliation: Department of Neurology, Taizhou First People's Hospital, Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China. Electronic address: hangbinhuang@126.com.
authors.forename: Gui-Hong
authors.initials: GH
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Taizhou First People's Hospital, Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: Department of Neurologic Intensive Care Unit, Taizhou First People's Hospital, Huangyan Hospital of Wenzhou Medical University, Taizhou 318020, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D054392:Adipokines / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000401:mortality; D000071451:Chitinase-3-Like Protein 1; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis; D037102:Lectins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012372:ROC Curve; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins
keywords: Inflammation; Intracerebral hemorrhage; Prognosis; YKL-40