title: Pregnancy outcomes in women with idiopathic thrombocytopenic purpura.
abstract: BACKGROUND
  Idiopathic thrombocytopenic purpura (ITP) is a disease that commonly affects women of reproductive age and is associated with maternal and fetal complications.
  
  
  OBJECTIVE
  The aim of the present study was to report the perinatal outcome in pregnant women with ITP.
  
  
  METHODS
  Twenty one pregnant women with ITP admitted in a teaching hospital in Tehran, from October 2008 to February 2010, were enrolled in this prospective historical cohort study; course and perinatal outcome of pregnancies were studied.
  
  
  RESULTS
  Seven (33.3%) cases had been diagnosed before pregnancy, while the other fourteen (66.7%) were diagnosed during pregnancy. During hospitalization, thirteen (62%) patients required treatment, eight (61.5%) of them with steroids, two (15.3%) received intravenous immunoglobulin (IVIG), and three (23%) were treated with steroids and IVIG. Three babies were delivered vaginally (14.3%), seventeen (81%) through cesarean section and one patient aborted her fetus. Nine mothers (42.9%) had platelet counts <50000/ml at the time of delivery; but postpartum hemorrhage occurred in 4 (19%) women and one women received platelet transfusion during cesarean section. Six (28.6%) women developed gestational diabetes. Pregnancy was complicated by preeclampsia in one woman and by abruptio placenta in another. One pregnancy terminated in intrauterine fetal death. Seventeen infants (89.5%) had normal platelet counts, and two (10.5%) had moderate thrombocytopenia. No infant showed signs of hemorrhage, but 2 neonates (10.5%) were diagnosed with intrauterine growth restriction.
  
  
  CONCLUSIONS
  Rate of gestational diabetes in pregnant women with ITP is higher than the general population. Rate of gestinational diabetes is 3-5% and postpartum hemorrhage is 5-7% in general. Postpartum hemorrhage is common in these women. Severe thrombocytopenia and bleeding in the newborns are uncommon.
authors.affiliation: Department of Obstetrics and Gynecology, Genomic Research Center, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
authors.forename: Fakhrolmolouk
authors.initials: F
authors.lastname: Yassaee
authors.affiliation: Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Taleghani Hospital, Tehran, Iran.
authors.forename: Roghieh
authors.initials: R
authors.lastname: Eskandari
authors.affiliation: Department of Basic Sciences, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Amiri
keywords: Idiopathic thrombocytopenic purpura; Neonatal outcome; Pregnancy outcomes