title: Persistent pure red cell aplasia in dicygotic twins with persistent congenital parvovirus B19 infection-remission following high dose intravenous immunoglobulin.
abstract: We report the course of dicygotic twins born preterm after 29 (4)/7 weeks of gestation due to congenital Parvovirus B19 infection causing fetal hydrops with severe anemia in one infant in whom intrauterine transfusion was impossible to perform and high levels of viremia in both infants. After being discharged, they were readmitted at 3 months of age with critical aplastic crisis. Therapy with intravenous immunoglobulin infusion resulted in decreasing viremia followed by stable hemoglobin levels in both infants.
  
  
  CONCLUSIONS
  Intravenous immunoglobulin treatment of congenital pure red cell aplasia due to Parvovirus B19 infection in preterm infants seems to be effective to introduce viral remission and to normalize erythropoiesis.
authors.affiliation: Pediatric Pulmonology/Immunology, Charité University Medical Center Berlin, Berlin, Germany, alice.lejeune@charite.de.
authors.forename: Alice
authors.initials: A
authors.lastname: Lejeune
authors.forename: Malte
authors.initials: M
authors.lastname: Cremer
authors.forename: Horst
authors.initials: H
authors.lastname: von Bernuth
authors.forename: Anke
authors.initials: A
authors.lastname: Edelmann
authors.forename: Susanne
authors.initials: S
authors.lastname: Modrow
authors.forename: Christoph
authors.initials: C
authors.lastname: Bührer
mesh_terms: D004279:DNA, Viral / Q000032:analysis*; D004200:Diseases in Twins / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage; D007231:Infant, Newborn; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood / Q000151:congenital* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics*; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D012074:Remission Induction; D014429:Twins, Dizygotic
chemical_list: D004279:DNA, Viral; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors