title: A simplified scoring system to document variant patterns in nodular lymphocyte predominant Hodgkin lymphoma.
abstract: This study sought to quantify variant patterns in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) using a three tier scoring system assessing five parameters, namely: (a) percentage of nodularity scored from 100 % to < 75%, (b) T cell rich areas (< 20% to > 50%), (c) type of nodules, (d) dendritic network, intact or lost, and (e) extranodular distribution of lymphocyte predominant cells (< 15% to > 50%), with final scores from 0 to 10. In the 72 patients assessed, the 5-year disease-free survival (DFS) in patients with score ≤ 6 was 92% vs. 20% in those with scores > 6. The 5-year overall survival was 100% in patients with scores ≤ 6 and 87% in those with scores > 6. In the multivariate Cox regression analysis, scores > 6 and stage impacted DFS. This scoring system was effective in stratifying patients with NLPHL with variant patterns and could be used for the management of patients.
authors.affiliation: Department of Pathology, Tata Memorial Hospital , Parel, Mumbai , India.
authors.forename: Tanuja
authors.initials: T
authors.lastname: Shet
authors.forename: Poonam
authors.initials: P
authors.lastname: Panjwani
authors.forename: Sridhar
authors.initials: S
authors.lastname: Epari
authors.forename: Manju
authors.initials: M
authors.lastname: Sengar
authors.forename: Maya
authors.initials: M
authors.lastname: Prasad
authors.forename: Brijesh
authors.initials: B
authors.lastname: Arora
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Laskar
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
authors.forename: Hari
authors.initials: H
authors.lastname: Menon
authors.forename: Shripad
authors.initials: S
authors.lastname: Banavali
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000145:classification* / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
keywords: Nodular lymphocyte predominant Hodgkin lymphoma; disease outcome; histology; scoring; variant pattern