title: Efficacy of anti-tachycardia pacing for terminating fast ventricular tachycardia in Japanese implantable cardioverter defibrillator patients. Primary results of the SATISFACTION study.
abstract: BACKGROUND
  Anti-tachycardia pacing (ATP) delivered by implantable cardioverter defibrillators (ICD) safely avoids painful shocks with minimum risk of tachycardia acceleration. The etiology of ventricular tachycardia (VT) in those studies, however, was predominantly coronary artery disease (CAD). Patient etiology differs by geography and could affect ATP efficacy rate. The primary objective of this study was to examine how often the first ATP therapy terminates fast VT (FVT) in Japanese ICD patients with regional etiologies. METHODS AND RESULTS: Seven hundred and fifteen patients received ICD or cardiac resynchronization therapy defibrillator with the function of ATP during capacitor charging. The primary endpoint was the first ATP success rate for terminating FVT with cycle length 240-320 ms. During a mean follow-up of 11.3 months, 888 spontaneous VT episodes were detected, including 276 FVT (31.1%) in 42 patients. The first-ATP success rate for FVT in the overall group (41% CAD, 59% non-CAD including 23% idiopathic VT) was 62.1% (61.7% adjusted). Success rate was not different between non-CAD and CAD patients (61.4% adjusted and 57.5% adjusted, respectively, P=0.75). Eight FVT episodes (2.9%) accelerated after the first ATP attempt, all of which were terminated by subsequent device therapy (additional ATP or shock).
  
  
  CONCLUSIONS
  ATP efficacy for FVT was similar between ICD patients with and without CAD etiology.
authors.affiliation: Cardiovascular Center, Kansai Rosai Hospital.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Watanabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Inoue
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kashiwase
authors.forename: Takanao
authors.initials: T
authors.lastname: Mine
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirooka
authors.forename: Ryu
authors.initials: R
authors.lastname: Shutta
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Shinya
authors.initials: S
authors.lastname: Shimoshige
authors.forename: Sou
authors.initials: S
authors.lastname: Takenaka
authors.forename: Takenori
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Yambe
authors.forename: Kinya
authors.initials: K
authors.lastname: Shirota
authors.forename: Junichi
authors.initials: J
authors.lastname: Nitta
authors.forename: Makoto
authors.initials: M
authors.lastname: Ito
authors.forename: Takehiko
authors.initials: T
authors.lastname: Keida
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Nanto
mesh_terms: D000368:Aged; D044466:Asian People; D002304:Cardiac Pacing, Artificial; D017147:Defibrillators, Implantable; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D017180:Tachycardia, Ventricular / Q000503:physiopathology* / Q000628:therapy*