title: Worming toward transdifferentiation, one (Epigenetic) step at a time.
abstract: Manipulation of cellular identity in the laboratory is generally inefficient due to stochastic events, including epigenomic alterations. Recently in Science, Zuryn et al. (2014) demonstrate that the efficiency of a naturally occurring transdifferentiation event in Caenorhabditis elegans is ensured through stepwise epigenetic modifications during specific phases of lineage conversion.
authors.affiliation: Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Ergin
authors.initials: E
authors.lastname: Beyret
authors.affiliation: Salk Institute for Biological Studies, Gene Expression Laboratory, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D054338:Cell Transdifferentiation; D056466:Histone Demethylases / Q000378:metabolism*; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D009046:Motor Neurons / Q000166:cytology*
chemical_list: D029742:Caenorhabditis elegans Proteins; D006657:Histones; D056466:Histone Demethylases; D011495:Histone-Lysine N-Methyltransferase