title: [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].
abstract: The neuroprotective activity of apolipoprotein E (apoE) peptide mimetic Cog1410, containing amino acid sequence of the receptor-binding domain apoE, has been investigated in transgenic lines of Drosophila melanogaster expressing human APP and beta-secretase. Expression of two transgenes caused neuropathological processes attributed to Alzheimer's disease: neurodegeneration, cognitive abnormality and amyloid deposits formation in brain. It was shown that Cog 1410 reduces neurodegeneration in brain of transgenic flies and improves cognitive functions (odor recognition). These data suggest that Cog1410 is a potential neuroprotector that can be used in AD treatment.
authors.forename: E M
authors.initials: EM
authors.lastname: Latypova
authors.forename: S I
authors.initials: SI
authors.lastname: Timoshenko
authors.forename: G A
authors.initials: GA
authors.lastname: Kislik
authors.forename: M
authors.initials: M
authors.lastname: Vitek
authors.forename: A L
authors.initials: AL
authors.lastname: Shvartsman
authors.forename: S V
authors.initials: SV
authors.lastname: Sarantseva
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D053829:Amyloid Precursor Protein Secretases / Q000235:genetics* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D030801:Animals, Genetically Modified; D001057:Apolipoproteins E / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003071:Cognition / Q000187:drug effects*; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009812:Odorants; D055696:Olfactory Perception / Q000187:drug effects; D019076:Transgenes
chemical_list: D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; C524548:COG1410; D018696:Neuroprotective Agents; D053829:Amyloid Precursor Protein Secretases
keywords: Cog1410; Drosophila melanogaster; apoE