title: Pharmacokinetics of meloxicam in mature swine after intravenous and oral administration.
abstract: The purpose of this study was to compare the pharmacokinetics of meloxicam in mature swine after intravenous (i.v.) and oral (p.o.) administration. Six mature sows (mean bodyweight ± standard deviation = 217.3 ± 65.68 kg) were administered an i.v. or p.o. dose of meloxicam at a target dose of 0.5 mg/kg in a cross-over design. Plasma samples collected up to 48 h postadministration were analyzed by high-pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by noncompartmental pharmacokinetic analysis. Mean peak plasma concentration (CMAX ) after p.o. administration was 1070 ng/mL (645-1749 ng/mL). TMAX was recorded at 2.40 h (0.50-12.00 h) after p.o. administration. Half-life (T½ λz ) for i.v. and p.o. administration was 6.15 h (4.39-7.79 h) and 6.83 h (5.18-9.63 h), respectively. The bioavailability (F) for p.o. administration was 87% (39-351%). The results of this study suggest that meloxicam is well absorbed after oral administration.
authors.affiliation: Department of Animal Science, Iowa State University, Ames, IA, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Pairis-Garcia
authors.forename: A K
authors.initials: AK
authors.lastname: Johnson
authors.forename: B
authors.initials: B
authors.lastname: KuKanich
authors.forename: L
authors.initials: L
authors.lastname: Wulf
authors.forename: S T
authors.initials: ST
authors.lastname: Millman
authors.forename: K J
authors.initials: KJ
authors.lastname: Stalder
authors.forename: L A
authors.initials: LA
authors.lastname: Karriker
authors.forename: J F
authors.initials: JF
authors.lastname: Coetzee
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D013058:Mass Spectrometry / Q000662:veterinary; D000077239:Meloxicam; D013552:Swine / Q000378:metabolism*; D013843:Thiazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013844:Thiazoles / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam