title: Retrospectively and prospectively modulated hippocampal place responses are differentially distributed along a common path in a continuous T-maze.
abstract: Hippocampal place responses can be prospectively or retrospectively modulated by the animal's future or prior trajectory. Two main hypotheses explain this. The "multiple-map hypothesis" switches between different maps for different trajectories (rate remapping). In contrast, in the "buffer hypothesis," the hippocampus encodes an ongoing representation that includes the recent past and/or the impending future choice. This study examines the distribution of prospective and retrospective responses distributed along a common path in a continuous T-maze (providing all four combinations of provenance and destination) during a visual discrimination task. The multiple-map hypothesis predicts either uniform distributions or concerted shifts about a task-decision relevant point, whereas the buffer hypothesis predicts a time-limited overexpression around choice points (with retrospective responses after the central arm entry point and prospective responses nearer its exit). Here bilateral recordings in the dorsal CA1 region of the rat hippocampus show that retrospective responses were twice as prevalent as prospective responses. Furthermore, retrospective and prospective modulations have distinct spatial distributions, with retrospective primarily in the first two-thirds of the central arm and prospective restricted to the last third. To test for possible trial-by-trial remapping in relation to the two-thirds transition point, data from the first and second halves of the sessions were compared. Backward drift of path-modulated activity was significant only for retrospective, but not prospective, fields. Thus, these data are more consistent with the buffer hypothesis. Retrospective and prospective modulation would then participate in a single hippocampal representation of spatial and behavioral context.
authors.affiliation: College de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France, and CNRS, UMR 7241, Paris F-75005, France catanese.julien@gmail.com sidney.wiener@college-de-france.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Catanese
authors.affiliation: College de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France, and CNRS, UMR 7241, Paris F-75005, France.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Viggiano
authors.affiliation: College de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France, and CNRS, UMR 7241, Paris F-75005, France.
authors.forename: Erika
authors.initials: E
authors.lastname: Cerasti
authors.affiliation: College de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France, and CNRS, UMR 7241, Paris F-75005, France.
authors.forename: Michaël B
authors.initials: MB
authors.lastname: Zugaro
authors.affiliation: College de France, Center for Interdisciplinary Research in Biology, Paris F-75005, France, and CNRS, UMR 7241, Paris F-75005, France catanese.julien@gmail.com sidney.wiener@college-de-france.fr.
authors.forename: Sidney I
authors.identifier: http://orcid.org/0000-0002-5819-1319
authors.initials: SI
authors.lastname: Wiener
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D003657:Decision Making; D004193:Discrimination Learning; D008297:Male; D018782:Maze Learning; D051381:Rats; D020318:Rats, Long-Evans; D014796:Visual Perception
keywords: extracellular recording; hippocampus; navigation; place cell; prospective; retrospective