title: Activity of the novel fungicide SYP-Z048 against plant pathogens.
abstract: In in vitro tests with 18 plant pathogens, the fungicide 3-[5-(4-chlorophenyl)-2,3-dimethyl-3-isoxazolidinyl] pyridine (SYP-Z048) was highly effective on inhibiting mycelial growth of various ascomycota and basidiomycota, with EC50 values ranging from 0.008 to 1.140 μg/ml. SYP-Z048 had much weaker activity against growth of oomycota with EC50 values > 100 μg/ml. In a second in vitro test with Monilinia fructicola isolates, SYP-Z048 inhibited mycelial growth (EC50 = 0.013 μg/ml), germ tube elongation (EC50 = 0.007 μg/ml), and sporulation but did not affect spore germination. In a detached pear fruit assay inoculated with M. fructicola isolates, SYP-Z048 showed protective and curative activity. Field tests indicated that SYP-Z048 was an efficacious fungicide for control of brown rot disease in two peach orchards. When applied to a single spot on a tomato leaflet in a compound leaf, SYP-Z048 suppressed the growth of Botrytis cinerea isolates on the rest 4 leaflets, indicating that the fungicide has systemic movement in plant tissues. These results indicate that SYP-Z048 has potential for management of brown rot causing by M. fructicola and other diseases caused by ascomycota and basidiomycota.
authors.affiliation: 1] Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou. 350002, China [2] Department of Plant Pathology, China Agricultural University, Beijing 100193, China.
authors.forename: Fengping
authors.initials: F
authors.lastname: Chen
authors.affiliation: 1] Department of Plant Pathology, China Agricultural University, Beijing 100193, China [2] Beijing Research Center for Agricultural Standards and Testing, Beijing 100097, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Han
authors.affiliation: Department of Plant Pathology, China Agricultural University, Beijing 100193, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Liu
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, China ShenYang Research Institute of Chemical Industry, Shenyang 110021, China.
authors.forename: Naiguo
authors.initials: N
authors.lastname: Si
authors.affiliation: State Key Laboratory of the Discovery and Development of Novel Pesticide, China ShenYang Research Institute of Chemical Industry, Shenyang 110021, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Plant Pathology, China Agricultural University, Beijing 100193, China.
authors.forename: Xili
authors.initials: X
authors.lastname: Liu
mesh_terms: D001203:Ascomycota / Q000187:drug effects* / Q000472:pathogenicity; D020171:Botrytis / Q000187:drug effects* / Q000472:pathogenicity; D005638:Fruit / Q000382:microbiology; D005659:Fungicides, Industrial / Q000008:administration & dosage*; D007555:Isoxazoles / Q000008:administration & dosage*; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development; D010935:Plant Diseases / Q000382:microbiology; D011725:Pyridines / Q000008:administration & dosage*; D031989:Pyrus / Q000382:microbiology
chemical_list: D005659:Fungicides, Industrial; D007555:Isoxazoles; D011725:Pyridines; C578054:SYP-Z048