title: Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human.
abstract: The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses on recent developments in understanding the role of Notch signaling in the human hematopoietic system with an emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Based on recent insights, we summarize potential strategies for treatment of human hematological malignancies toward the concept of targeting Notch signaling for fate regulation.
authors.affiliation: McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
authors.forename: Rahul
authors.initials: R
authors.lastname: Kushwah
authors.affiliation: McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
authors.forename: Borhane
authors.initials: B
authors.lastname: Guezguez
authors.affiliation: McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
authors.forename: Jung Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.
authors.forename: Claudia I
authors.initials: CI
authors.lastname: Hopkins
authors.affiliation: McMaster Stem Cell and Cancer Research Institute (SCC-RI), Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada mbhatia@mcmaster.ca.
authors.forename: Mickie
authors.initials: M
authors.lastname: Bhatia
mesh_terms: D058685:Genetic Pleiotropy; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism*; D051880:Receptors, Notch / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch
keywords: Notch; hematopoiesis; human pluripotent stem cells; leukemia