title: A systematic review of intermittent pneumatic compression for critical limb ischaemia.
abstract: Intermittent pneumatic compression (IPC) is designed to aid wound healing and limb salvage for patients with critical limb ischaemia who are not candidates for revascularisation. We conducted a systematic review of the literature to identify and critically appraise the evidence supporting its use in this population. A search was conducted in Embase, MEDLINE and clinical trial registries up to the end of March 2013. No date or language restrictions were applied. Quality assessment was performed by two people independently. Quality was assessed using the Cochrane risk of bias tool and the NICE case-series assessment tool. Two controlled before-and-after (CBA) studies and six case series were identified. One retrospective CBA study involving compression of the calf reported improved limb salvage and wound healing (OR 7.00, 95% CI 1.82 to 26.89, p<0.01). One prospective CBA study involving sequential compression of the foot and calf reported statistically significant improvements in claudication distances and SF-36 quality of life scores. No difference in all-cause mortality was found. Complications included pain associated with compression, as well as skin abrasion and contact rash as a result of the cuff rubbing against the skin. All studies had a high risk of bias. In conclusion, the limited available results suggest that IPC may be associated with improved limb salvage, wound healing and pain management. However, in the absence of additional well-designed analytical studies examining the effect of IPC in critical limb ischaemia, this treatment remains unproven.
authors.affiliation: Health Information and Quality Authority, Dublin, Ireland pmoran@hiqa.ie.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Moran
authors.affiliation: Health Information and Quality Authority, Dublin, Ireland.
authors.forename: Conor
authors.initials: C
authors.lastname: Teljeur
authors.affiliation: Health Information and Quality Authority, Dublin, Ireland.
authors.forename: Patricia
authors.initials: P
authors.lastname: Harrington
authors.affiliation: Health Information and Quality Authority, Dublin, Ireland.
authors.forename: Mairin
authors.initials: M
authors.lastname: Ryan
mesh_terms: D000671:Amputation, Surgical; D016638:Critical Illness; D005080:Exercise Test; D017079:Exercise Tolerance; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D048228:Intermittent Pneumatic Compression Devices / Q000009:adverse effects; D007511:Ischemia / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D023821:Limb Salvage; D010147:Pain Measurement; D011788:Quality of Life; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing
keywords: amputation; peripheral arterial disease; ulcer; vascular surgical procedures