title: Oligo-β-(1 → 3)-glucans: impact of thio-bridges on immunostimulating activities and the development of cancer stem cells.
abstract: Recent developments of innovative anticancer therapies are based on compounds likely to stimulate the immune defense of the patients. β-(1 → 3)-Glucans are natural polysaccharides well-known for their immunostimulating properties. We report here on the synthesis of small oligo-β-(1 → 3)-glucans characterized by thioglycosidic linkages. The presence of sulfur atom(s) was not only crucial to prolong in vivo immunoactive activities in time, compared to native polysaccharides, but sulfur atoms also had a direct impact on the development of colorectal cancer stem cells. As a result, a short, pure, and structurally well-defined trisaccharidic thioglucan demonstrated similar activities compared to those of natural laminarin.
authors.affiliation: Ecole Nationale Supérieure de Chimie de Rennes, CNRS, UMR 6226, 11 Allée de Beaulieu, CS 50837, 35708 Rennes Cedex 7, France.
authors.forename: Balla
authors.initials: B
authors.lastname: Sylla
authors.forename: Laurent
authors.initials: L
authors.lastname: Legentil
authors.forename: Sujata
authors.initials: S
authors.lastname: Saraswat-Ohri
authors.forename: Aruna
authors.initials: A
authors.lastname: Vashishta
authors.forename: Richard
authors.initials: R
authors.lastname: Daniellou
authors.forename: Hsei-Wei
authors.initials: HW
authors.lastname: Wang
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
authors.forename: Vincent
authors.initials: V
authors.lastname: Ferrières
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002460:Cell Line / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D016207:Cytokines / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005260:Female; D005936:Glucans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D014411:Neoplastic Stem Cells / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D013329:Structure-Activity Relationship; D013455:Sulfur / Q000737:chemistry; D014312:Trisaccharides / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D016207:Cytokines; D005936:Glucans; D014312:Trisaccharides; D013455:Sulfur; C008247:laminaran