title: The effect of surveillance on the outcome of breast cancer patients.
abstract: BACKGROUND
  The beginning of metastasis poorly affects the prognosis of breastcancer patients. Lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. We have tried to find out if the routine Chest X Ray (CXR) could play a role for early detection of lung metastasis, during the prognosis of these patients.
  
  
  METHODS
  The files of the breast cancer patients between 1996 to 2006 (1739 patients) have reviewed. Clinical characteristics of patients with pulmonary metastasis have recorded. Patients, who lacked imaging files or lacked an appropriate follow-up, have excluded. Data have analyzed by SPSS 11.5. The survival analyses have performed by using the Kaplan-Meier method.
  
  
  RESULTS
  Fifty-six patients, median age 46, have entered into this retrospective study. Median tumor size was 4cm; median number of Lymphadenopathy (LAP) was 4. The intermediate grade has detected in 74% of patients. All patients have received adjuvant treatment. Median time from cancer diagnosis to pulmonary metastasis was 22 months. Pulmonary metastasis has detected by control CXR in77.4% and patients' symptoms in 22.6%. Forty eight patients have received chemotherapy in metastatic phase. In 28 patients (50%), other sites of metastasis (bone, liver, and brain) have discovered.The most frequent pattern of lung recurrence was pulmonary nodule (44.6%), followed by pleural effusion (28.6%). Median survival was 27.5; median survival from pulmonary metastasis was 8 m.
  
  
  CONCLUSIONS
  Early detection of pulmonary metastasis by CXR did not affect patients' endpoints. None of the probable prognostic factors have shown a significant effect on patients' outcome. Despite systemic treatment, survival after metastasis is low.
authors.affiliation: Cancer Research Center, Omid Hospital ,Faculty of Medicine, Mashad University of Medical Sciences, Mashad, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Anvari
authors.affiliation: Cancer Research Center, Omid Hospital ,Faculty of Medicine, Mashad University of Medical Sciences, Mashad, Iran.
authors.forename: Azar
authors.initials: A
authors.lastname: Fanipakdel
authors.affiliation: Dept. of Radiology, Imam Reza Hospital, Mashad University of Medical Sciences, Mashad, Iran.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Davoudi
keywords: Breast cancer; Lung metastas; Surveillance