title: Diffuse intrinsic pontine glioma biopsy: a single institution experience.
abstract: Tumor biopsy is rarely performed in diffuse intrinsic pontine glioma (DIPG) due to the presumed risk of surgical complications, although data on the surgery related morbidity of DIPG biopsy is sparse. We performed a retrospective review on 22 consecutive cases of DIPG diagnosed from 2002 to 2012 at Children's Hospital of Michigan, 15 of which underwent biopsy. Transient new or worsening neurological deficits were observed in three of 15 cases following surgery. No surgery related mortality or permanent deficit was observed, and the mean overall survival was 10.4 ± 3.8 months. Undergoing biopsy did not adversely affect the outcome.
authors.affiliation: Pediatric Hematology Oncology, The Carman and Ann Adams Department of Pediatrics, Wayne State University, 3901 Beaubien Street, Detroit, Michigan, 48201.
authors.forename: Zhihong J
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Latha
authors.initials: L
authors.lastname: Rao
authors.forename: Kanta
authors.initials: K
authors.lastname: Bhambhani
authors.forename: Kathy
authors.initials: K
authors.lastname: Miller
authors.forename: Janet
authors.initials: J
authors.lastname: Poulik
authors.forename: Deniz
authors.initials: D
authors.lastname: Altinok
authors.forename: Sandeep
authors.initials: S
authors.lastname: Sood
mesh_terms: D000293:Adolescent; D001706:Biopsy; D020295:Brain Stem Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging; D005260:Female; D005500:Follow-Up Studies; D005910:Glioma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
keywords: DIPG; astrocytoma; biopsy