title: Correlation between central corneal thickness and visual field defect, cup to disc ratio and retinal nerve fiber layer thickness in primary open-angle glaucoma patients.
abstract: OBJECTIVE
  To assess the correlation between central corneal thickness (CCT) and visual field parameters, cup-to-disc ratio and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) patients in Songklanagarind Hospital.
  
  
  METHODS
  A Retrospective analytical study of the medical records of primary open-angle glaucoma patients, between January 2006 and April 2008, were reviewed. All subjects underwent a complete eye examination. The CCT measurement was performed by ultrasonic pachymeter Mean deviation (MD), pattern standard deviation (PSD), cup-to-disc ratio, and the RNFL thickness of each patient were collected. The correlation coefficient between CCT and MD, PSD, cup-to-disc ratio and RNFL thickness was analyzed.
  
  
  RESULTS
  Twenty-six POAG patients (47 eyes) were eligible for the study. Mean age was 60.96 +/- 7.44 years. Average CCT was 511.15 +/- 29.66 microm. Mean AMD and PSD were--10.01 +/- 8.20 and 7.52 +/- 4.43 decibel respectively. Mean cup-to-disc ratio was 0.7 1+/- 0.17. Mean RNFL thickness of superior inferior temporal, nasal quadrants and all quadrants were 101.60 +/- 28.68, 87.15 +/- 32.56, 60.64 +/- 14.14, 61.83 +/- 13.96 and 77.80 +/-17.58 microm, respectively. There were significant correlations between CCT and MD (r = 0.532, p < 0.001), PSD (r = -0.288, p = 0.05), cup-to-disc ratio (r = -0.478, p = 0.001), and average RNFL thickness (r = 0.487, p = 0.001).
  
  
  CONCLUSIONS
  There were significant correlations between CCT and visual field parameters, cup-to-disc ratio, and RNFL thickness.
authors.forename: Boonchai
authors.initials: B
authors.lastname: Wangsupadilok
authors.forename: Lachaya
authors.initials: L
authors.lastname: Orapiriyakul
mesh_terms: D000368:Aged; D003315:Cornea / Q000033:anatomy & histology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D012160:Retina / Q000473:pathology; D055351:Retinal Neurons / Q000473:pathology*; D012189:Retrospective Studies; D014794:Visual Fields