title: Pullout strength of cancellous screws in human femoral heads depends on applied insertion torque, trabecular bone microarchitecture and areal bone mineral density.
abstract: For cancellous bone screws, the respective roles of the applied insertion torque (TInsert) and of the quality of the host bone (microarchitecture, areal bone mineral density (aBMD)), in contributing to the mechanical holding strength of the bone-screw construct (FPullout), are still unclear. During orthopaedic surgery screws are tightened, typically manually, until adequate compression is attained, depending on surgeons' manual feel. This corresponds to a subjective insertion torque control, and can lead to variable levels of tightening, including screw stripping. The aim of this study, performed on cancellous screws inserted in human femoral heads, was to investigate which, among the measurements of aBMD, bone microarchitecture, and the applied TInsert, has the strongest correlation with FPullout. Forty six femoral heads were obtained, over which microarchitecture and aBMD were evaluated using micro-computed tomography and dual X-ray absorptiometry. Using an automated micro-mechanical test device, a cancellous screw was inserted in the femoral heads at TInsert set to 55% to 99% of the predicted stripping torque beyond screw head contact, after which FPullout was measured. FPullout exhibited strongest correlations with TInsert (R=0.88, p<0.001), followed by structure model index (SMI, R=-0.81, p<0.001), bone volume fraction (BV/TV, R=0.73, p<0.001) and aBMD (R=0.66, p<0.01). Combinations of TInsert with microarchitectural parameters and/or aBMD did not improve the prediction of FPullout. These results indicate that, for cancellous screws, FPullout depends most strongly on the applied TInsert, followed by microarchitecture and aBMD of the host bone. In trabecular bone, screw tightening increases the holding strength of the screw-bone construct.
authors.affiliation: Biomechanics & Implants Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia. Electronic address: abla0002@flinders.edu.au.
authors.forename: Rosidah
authors.initials: R
authors.lastname: Ab-Lazid
authors.affiliation: Biomechanics & Implants Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia.
authors.forename: Egon
authors.initials: E
authors.lastname: Perilli
authors.affiliation: Biomechanics & Implants Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia.
authors.forename: Melissa K
authors.initials: MK
authors.lastname: Ryan
authors.affiliation: Biomechanics & Implants Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia.
authors.forename: John J
authors.initials: JJ
authors.lastname: Costi
authors.affiliation: Biomechanics & Implants Research Group, Medical Device Research Institute, School of Computer Science, Engineering and Mathematics, Flinders University, Adelaide, SA, Australia.
authors.forename: Karen J
authors.initials: KJ
authors.lastname: Reynolds
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001696:Biomechanical Phenomena / Q000502:physiology; D015519:Bone Density / Q000502:physiology*; D001863:Bone Screws; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D019415:Torque
keywords: Areal bone mineral density; Micro-computed tomography; Microarchitecture; Screw pullout strength; Trabecular bone