title: Analysis of vascular closure devices after transbrachial artery access.
abstract: BACKGROUND
  We seek to determine whether vascular closure devices (VCDs) are safe and effective for brachial artery access.
  
  
  METHODS
  A retrospective review of brachial artery access using either manual compression (MC) or a VCD for hemostasis from November 2005 to February 2011 was performed.
  
  
  RESULTS
  Brachial artery access was performed on 154 limbs: MC on 134 limbs and VCD on 20 limbs. The incidence of thrombotic (VCD n = 0 [0%] vs MC n = 7 [5.2%], P = .37), hemorrhagic complications (VCD n = 1 [5%] vs MC n = 7 [5.2%], P = .72), or major adverse events (VCD n = 1 [5%] vs MC n = 16 [12%], P = .32) was not significantly different between the techniques. After univariate and multivariate analysis, female sex (P = .07, relative risk [RR] = 5.7), sheath size > 6F (P = .008, RR = 14.6), and diagnostic versus interventional procedure (P = .04, RR = 0.4) all impacted the occurrence of thrombosis.
  
  
  CONCLUSIONS
  Use of VCD in the brachial artery following an endovascular procedure showed equivalence to MC.
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA akhm88@gmail.com.
authors.forename: Aleem K H
authors.initials: AK
authors.lastname: Mirza
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Samuel N
authors.initials: SN
authors.lastname: Steerman
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Sadaf S
authors.initials: SS
authors.lastname: Ahanchi
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Higgins
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Sirisha
authors.initials: S
authors.lastname: Mushti
authors.affiliation: Eastern Virginia Medical School, Norfolk, VA, USA.
authors.forename: Jean M
authors.initials: JM
authors.lastname: Panneton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001916:Brachial Artery; D002406:Catheterization, Peripheral / Q000009:adverse effects*; D016009:Chi-Square Distribution; D004867:Equipment Design; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006489:Hemostatic Techniques / Q000009:adverse effects / Q000295:instrumentation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011312:Pressure; D011677:Punctures; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D065506:Vascular Closure Devices
keywords: brachial artery thrombosis; hemorrhagic complications; hemostasis; manual compression; thrombotic complications; vascular closure device