title: New interview and observation measures of the broader autism phenotype: group differentiation.
abstract: To identify the broader autism phenotype (BAP), the Family History Interview subject and informant versions and an observational tool (Impression of Interviewee), were developed. This study investigated whether the instruments differentiated between parents of children with autism, and parents of children with Down syndrome (DS). The BAP scores of parents of 28 multiplex autism families were compared with parents from, 32 DS families. The BAP measures provided good group differentiation but when considered together, the subject interview did not improve group differentiation. The differentiation was better for fathers than mothers. The measures do carry an important degree of validity; whether they can differentiate the BAP from other social disorders should be tested.
authors.affiliation: Department of Psychiatry, University Medical Center Utrecht, Room A01.468, Postbox 85500, 3508 GA, Utrecht, The Netherlands, m.v.jonge@umcutrecht.nl.
authors.forename: Maretha
authors.initials: M
authors.lastname: de Jonge
authors.forename: Jeremy
authors.initials: J
authors.lastname: Parr
authors.forename: Michael
authors.initials: M
authors.lastname: Rutter
authors.forename: Simon
authors.initials: S
authors.lastname: Wallace
authors.forename: Chantal
authors.initials: C
authors.lastname: Kemner
authors.forename: Anthony
authors.initials: A
authors.lastname: Bailey
authors.forename: Herman
authors.initials: H
authors.lastname: van Engeland
authors.forename: Andrew
authors.initials: A
authors.lastname: Pickles
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D002648:Child; D005220:Fathers / Q000523:psychology; D005260:Female; D006801:Humans; D007406:Interview, Psychological / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009035:Mothers / Q000523:psychology; D010641:Phenotype; D012919:Social Behavior; D055815:Young Adult