title: 3D molecular models of whole HIV-1 virions generated with cellPACK.
abstract: As knowledge of individual biological processes grows, it becomes increasingly useful to frame new findings within their larger biological contexts in order to generate new systems-scale hypotheses. This report highlights two major iterations of a whole virus model of HIV-1, generated with the cellPACK software. cellPACK integrates structural and systems biology data with packing algorithms to assemble comprehensive 3D models of cell-scale structures in molecular detail. This report describes the biological data, modeling parameters and cellPACK methods used to specify and construct editable models for HIV-1. Anticipating that cellPACK interfaces under development will enable researchers from diverse backgrounds to critique and improve the biological models, we discuss how cellPACK can be used as a framework to unify different types of data across all scales of biology.
authors.affiliation: University of California, San Francisco, CA 94143, USA. graham.johnson@ucsf.edu.
authors.forename: Graham T
authors.initials: GT
authors.lastname: Johnson
authors.forename: David S
authors.initials: DS
authors.lastname: Goodsell
authors.forename: Ludovic
authors.initials: L
authors.lastname: Autin
authors.forename: Stefano
authors.initials: S
authors.lastname: Forli
authors.forename: Michel F
authors.initials: MF
authors.lastname: Sanner
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Olson
mesh_terms: D015497:HIV-1 / Q000648:ultrastructure*; D008958:Models, Molecular; D012984:Software; D014771:Virion / Q000648:ultrastructure*