title: [Effect of melaxen and valdoxan on free radical processes intensity, aconitate hydratase activity and citrate content in rats tissues under hyperthyroidism].
abstract: The influence of melaxen and valdoxan on the biochemiluminescence parameters, aconitate hydratase activity and citrate level in rats heart and liver during development of experimental hyperthyroidism has been investigated. Administration of these substances promoted a decrease of biochemiluminescence parameters, which had been increased in tissues of rats in response to the development of oxidative stress under hyperthyroidism. Aconitate hydratase activity and citrate concentration in rats liver and heart, growing at pathological conditions, changed towards control value after administration of the drugs correcting melatonin level. The results indicate the positive effect of valdoxan and melaxen on oxidative status of the organism under the development of experimental hyperthyroidism that is associated with antioxidant action of melatonin.
authors.forename: M V
authors.initials: MV
authors.lastname: Gorbenko
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.forename: K K
authors.initials: KK
authors.lastname: Shul'gin
authors.forename: S S
authors.initials: SS
authors.lastname: Popov
authors.forename: A A
authors.initials: AA
authors.lastname: Agarkov
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000154:Aconitate Hydratase / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002951:Citrates / Q000378:metabolism*; D004357:Drug Synergism; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D006980:Hyperthyroidism / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008163:Luminescent Measurements; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress; D051381:Rats; D014284:Triiodothyronine; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000154:Aconitate Hydratase; D000975:Antioxidants; D002951:Citrates; D005609:Free Radicals; D008550:Melatonin; D014284:Triiodothyronine; C084711:agomelatine; D009281:Naphthalenes
keywords: experimental hyperthyroidism; free-radical oxidation; melaksen; valdoxan