title: t(1:14) and trisomy 4 in a patient with concomitant leukaemias.
abstract: Cytogenetic abnormalities have long been recognized as the genetic basis of the occurrence of various malignancies. Specific cytogenetic abnormalities have shown to occur recurrently in particular subtypes of leukaemias and lymphomas. t(1;14) is an infrequently occurring recurrent chromosomal translocation that has been described in literature to be associated with haematological malignancies. Trisomy 4 is another rare genetic abnormality which has been reported in association with both acute myeloid and lymphoid leukaemias. The concomitant occurrence of a myeloid malignancy in association with a lymphoproliferative disorder is a distinctly unusual phenomenon. We report the case of a young patient with concomitant T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia with a novel cytogenetic abnormality i.e. t(1;14) with trisomy 4. We believe this is the first reported case where a patient with two concomitant haematological malignancies, harboured this karyotype.
authors.forename: Muhammad Nauman
authors.initials: MN
authors.lastname: Zahir
authors.forename: Nehal
authors.initials: N
authors.lastname: Masood
authors.forename: Munira
authors.initials: M
authors.lastname: Shabbir-Moosajee
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000453:epidemiology* / Q000235:genetics*; D009378:Neoplasms, Multiple Primary; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology* / Q000235:genetics*; D014178:Translocation, Genetic; D014314:Trisomy