title: Uncomplicated diabetes does not accelerate age-related sarcopenia.
abstract: BACKGROUND
  Diabetes is reported to accelerate sarcopenia (age-related loss of muscle mass and function). We aimed to assess muscle mass and strength in elderly diabetics, elderly non-diabetics, younger diabetics and healthy subjects, and to define correlates of muscle mass and strength in these subjects.
  
  
  METHODS
  Sixteen elderly diabetics, 16 younger diabetics, 16 elderly non-diabetics and 18 younger non-diabetics were included. Elderly and diabetic subjects were first evaluated with exercise testing. Isokinetic leg extension and flexion tests were performed using a Cybex 350 dynamometer. Muscle mass was calculated using bioelectric impedance analysis.
  
  
  RESULTS
  Muscle mass was similar between all groups; however, muscle strength was significantly lower in diabetic and non-diabetic elderly subjects compared with younger diabetic subjects and non-diabetics. Muscle strength was positively correlated with albumin, metabolic equivalent and hemoglobin, and inversely correlated with age, HbA1c, functional capacity and CRP. Independent correlates of muscle strength were age and hemoglobin. There was no clinically significant correlate of muscle mass. Presence or duration of diabetes was not associated with muscle mass or strength.
  
  
  CONCLUSIONS
  Uncomplicated diabetes does not seem to accelerate aging-related muscle mass or strength loss. Exercise test parameters may be useful markers in the screening of sarcopenia.
authors.affiliation: Department of Internal Medicine .
authors.forename: Timur Selcuk
authors.initials: TS
authors.lastname: Akpinar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tayfur
authors.forename: Fatih
authors.initials: F
authors.lastname: Tufan
authors.forename: Türker
authors.initials: T
authors.lastname: Sahinkaya
authors.forename: Murat
authors.initials: M
authors.lastname: Köse
authors.forename: Ekmel Burak
authors.initials: EB
authors.lastname: Özşenel
authors.forename: Gülistan
authors.initials: G
authors.lastname: Bahat Öztürk
authors.forename: Bülent
authors.initials: B
authors.lastname: Saka
authors.forename: Nilgün
authors.initials: N
authors.lastname: Erten
authors.forename: Safinaz
authors.initials: S
authors.lastname: Yildiz
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Karan
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D048909:Diabetes Complications / Q000175:diagnosis* / Q000503:physiopathology; D005080:Exercise Test; D006801:Humans; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D018482:Muscle, Skeletal / Q000503:physiopathology; D055948:Sarcopenia / Q000209:etiology* / Q000503:physiopathology; D055815:Young Adult
keywords: Aging; diabetes mellitus; exercise test; isokinetic muscle strength; sarcopenia