title: Application of vincristine-loaded platelet therapy in three dogs with refractory immune-mediated thrombocytopenia.
abstract: Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly with improved clinical signs while the third dog with recurrent IMT was euthanized due to its deteriorating condition. This case report describes the efficacy of VLP therapy in refractory IMT patients.
authors.affiliation: College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
authors.forename: Hyung-Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Ja-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Kun-Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Kyoung-Won
authors.initials: KW
authors.lastname: Seo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D008297:Male; D017713:Platelet Transfusion / Q000379:methods / Q000662:veterinary*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy / Q000662:veterinary*; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine
keywords: refractory immune-mediated thrombocytopenia; vincristine-loaded platelets