title: Use of nonsteroidal anti-inflammatory drugs in colorectal surgery: do the risks cast a shadow on the benefits?
abstract: Nonsteroidal anti-inflammatory drug (NSAID) use is recognized as a key component of the Enhanced Recovery After Surgery protocols and is systematically recommended in colorectal surgery to optimize perioperative care. However, a red flag about this practice has been raised because clinical studies have recently pointed out an increased risk of anastomotic leak after colorectal surgery following NSAID administration. Therefore, we used the Bradford Hill criteria to examine this potential relationship and concluded that use of perioperative NSAIDs in colorectal surgery should be evaluated carefully and on an individual basis considering the potentially increased risk of anastomotic leak and its consequences.
authors.affiliation: CHU de Québec, Québec, Canada.
authors.forename: Mélissa
authors.initials: M
authors.lastname: Blouin
authors.affiliation: CHU de Québec, Québec, Canada marc.rhainds@chuq.qc.ca.
authors.forename: Marc
authors.initials: M
authors.lastname: Rhainds
mesh_terms: D057868:Anastomotic Leak / Q000139:chemically induced; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D006801:Humans; D059035:Perioperative Period; D018570:Risk Assessment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: NSAID; anastomotic leak; colorectal surgery; nonsteroidal anti-inflammatory drug