title: Influence of neurobehavioral incentive valence and magnitude on alcohol drinking behavior.
abstract: The monetary incentive delay (MID) task is a widely used probe for isolating neural circuitry in the human brain associated with incentive motivation. In the present functional magnetic resonance imaging (fMRI) study, 82 young adults, characterized along dimensions of impulsive sensation seeking, completed a MID task. fMRI and behavioral incentive functions were decomposed into incentive valence and magnitude parameters, which were used as predictors in linear regression to determine whether mesolimbic response is associated with problem drinking and recent alcohol use. Alcohol use was best explained by higher fMRI response to anticipation of losses and feedback on high gains in the thalamus. In contrast, problem drinking was best explained by reduced sensitivity to large incentive values in mesolimbic regions in the anticipation phase and increased sensitivity to small incentive values in the dorsal caudate nucleus in the feedback phase. Altered fMRI responses to monetary incentives in mesolimbic circuitry, particularly those alterations associated with problem drinking, may serve as potential early indicators of substance abuse trajectories.
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA. Electronic address: josep@musc.edu.
authors.forename: Jane E
authors.initials: JE
authors.lastname: Joseph
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Christine R
authors.initials: CR
authors.lastname: Corbly
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA.
authors.forename: Stacia
authors.initials: S
authors.lastname: DeSantis
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Dustin C
authors.initials: DC
authors.lastname: Lee
authors.affiliation: Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425-0616, USA.
authors.forename: Grace
authors.initials: G
authors.lastname: Baik
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Kiser
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Yang
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Donald R
authors.initials: DR
authors.lastname: Lynam
authors.affiliation: University of Kentucky, 410 Administration Drive, Lexington, KY 40508-0001, USA.
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Kelly
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D000428:Alcohol Drinking / Q000503:physiopathology*; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003342:Corpus Striatum / Q000502:physiology; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009042:Motivation / Q000502:physiology*; D013788:Thalamus / Q000502:physiology; D055815:Young Adult
keywords: Alcohol use; Impulsivity; Monetary incentive delay; Problem drinking; Sensation seeking; fMRI