title: Water soluble polysaccharides extracted from Pterocladia capillacea and Dictyopteris membranacea and their biological activities.
abstract: Cold and hot water extracts (CWE, HWE) of both the red alga Pterocladia capillacea (P. capillacea) and the brown alga Dictyopteris membranacea (D. membranacea) were studied for their polysaccharide contents. In both (CWE) and (HWE) extracts. Relatively higher yields were obtained in case of P. capillacea pillacea (2.87 and 6.46%, respectively). The polysaccharide contents of the CWE hydrolyzate of both studied algae analyzed by HPLC were found to be enriched with glucuronic acid, arabinose and glucose, whereas, HWE hydrolyzate were found to be rich in glucuronic acid and fructose. The polysaccharide contents of the CWE and HWE extracts of (D. membranacea) showed appreciable antimicrobial activity in addition to a moderate antitumor activity against HELA (Cervix carcinoma cell line) at IC50 = 9.83 μg/dl, respectively. Whereas the polysaccharide contents of the CWE and HWE extracts of (P. capillacea) exhibited a promising anticoagulant activity.
authors.affiliation: Pharmacognosy Department, National Research Centre, Dokki, Cairo 12311, Egypt. Electronic address: abouzeida@yahoo.co.uk.
authors.forename: A H
authors.initials: AH
authors.lastname: Abou Zeid
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Kasr Al-Aini, Cairo University, 11562, Egypt.
authors.forename: E A
authors.initials: EA
authors.lastname: Aboutabl
authors.affiliation: Pharmacology Department, National Research Centre, Dokki, Cairo 12311, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Sleem
authors.affiliation: Pharmacognosy Department, National Research Centre, Dokki, Cairo 12311, Egypt.
authors.forename: H M
authors.initials: HM
authors.lastname: El-Rafie
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry; D000925:Anticoagulants / Q000737:chemistry; D000935:Antifungal Agents / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry; D005260:Female; D020723:Glucuronic Acid / Q000032:analysis; D006367:HeLa Cells; D006801:Humans; D008297:Male; D009005:Monosaccharides / Q000032:analysis; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D000461:Rhodophyta / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000925:Anticoagulants; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D009005:Monosaccharides; D011134:Polysaccharides; D014867:Water; D020723:Glucuronic Acid
keywords: Anticoagulant activities; Antimicrobial; Antitumor; Dictyopteris membranacea; Polysaccharides; Pterocladia capillacea