title: Vitamin D insufficiency is associated with lower physical function in patients with heart failure and diabetes.
abstract: Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥ 30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C, n = 25), vitamin sufficient, diabetes (DS-DM, n = 18), vitamin deficient, no diabetes (DD-C, n = 63), and vitamin deficient, diabetes (DD-DM, n = 40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups (P = 0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m) versus DD-DM (309 ± 116 m); P = 0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM (P = 0.074) even after being adjusted to physical activity (P = 0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.
authors.affiliation: Endocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: M R
authors.initials: MR
authors.lastname: Lopes
authors.affiliation: Cardiology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Paula A B
authors.initials: PA
authors.lastname: Ribeiro
authors.affiliation: Endocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Priscila
authors.identifier: 0000-0002-4606-7353
authors.initials: P
authors.lastname: Ledur
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Gabriela C
authors.initials: GC
authors.lastname: Souza
authors.affiliation: Cardiology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Cardiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
authors.forename: Nadine
authors.initials: N
authors.lastname: Clausell
authors.affiliation: Endocrinology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Cardiology Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Department of Internal Medicine, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil ; Endocrinology Division, Hospital de Clínicas de Porto Alegre, Serviço de Endocrinologia, Rua Ramiro Barcelos 2350, Prédio 12, 4° Andar, 90035-003 Porto Alegre, RS, Brazil.
authors.forename: Beatriz D
authors.initials: BD
authors.lastname: Schaan
mesh_terms: D000328:Adult; D000368:Aged; D055109:Ankle Brachial Index; D001794:Blood Pressure; D001823:Body Composition; D001938:Brazil; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D018737:Hand Strength; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D062606:Tertiary Care Centers; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications*; D016138:Walking
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D