title: Successful treatment with tocilizumab in a case of intralymphatic histiocytosis associated with rheumatoid arthritis.
abstract: A 75-year-old woman with rheumatoid arthritis (RA) presented with long-term painful erythema on the right upper arm and left elbow. The patient was diagnosed with intralymphatic histiocytosis (ILH) based on the biopsy findings. Because the patient was unresponsive to single-agent treatment with methotrexate, infliximab and etanercept, we switched to tocilizumab (TCZ) treatment, which induced remission of the ILH. Our case suggests that TCZ may be a treatment option for ILH in patients with RA.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawabata
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Nakabo
authors.forename: Aya
authors.initials: A
authors.lastname: Miyagawa-Hayashino
authors.forename: Naoichiro
authors.initials: N
authors.lastname: Yukawa
authors.forename: Hajime
authors.initials: H
authors.lastname: Yoshifuji
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ohmura
authors.forename: Takao
authors.initials: T
authors.lastname: Fujii
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D015614:Histiocytosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab