title: A new flavonone from seeds of Alpinia katsumadai and its neuroprotective effect on PC12 cells.
abstract: A new flavonone, named as (2R, 3S)-pinobanksin-3-cinnamate(1), together with six known compounds, pinocem-brin (2), pinobanksin (3), 3-O-acetylpinobanksin (4), galangin (5), kumatakenin(6), and 3-methylkaempferol (7), were isolated from a 95% ethanol extract of seeds of Alpinia katsumadai through a combination of various chromatographic techniques, including silica gel and Sephadex LH-20. The structure of compound 1 was elucidated by spectroscopic data analysis. Compound 1 exhibits a potent neuroprotective effect against the corticosterone-damaged PC12 cells, which may be underlying the effect by scavenging intracellular ROS.
authors.forename: Ben-Ru
authors.initials: BR
authors.lastname: Xin
authors.forename: Shou-Juan
authors.initials: SJ
authors.lastname: Ren
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002783:Cholestenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053938:DNA Fragmentation / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012639:Seeds / Q000737:chemistry*
chemical_list: C000591505:(2R,3S)-pinobanksin-3-cinnamate; D002783:Cholestenones; D002934:Cinnamates; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species