title: Atopic diathesis in hypohidrotic/anhidrotic ectodermal dysplasia.
abstract: Recently, patients with hypohidrotic/anhidrotic ectodermal dysplasia (H/AED) have been reported to have a higher prevalence of symptoms suggestive of atopic disorders than the general population. To better understand atopic diathesis in H/AED, 6 cases of clinically or genetically diagnosed H/AED were examined. The following criteria were evaluated with patient consent: sweating, blood test results, histopathology and filaggrin staining. Five of 6 H/AED cases displayed atopic dermatitis-like manifestations, and 3 of these 5 cases experienced periorbital lesions. H/AED patients tended to present with atopic dermatitis-like eruptions with characteristics potentially indicative of periorbital lesions. Atopic diathesis in H/AED appeared not to be associated with filaggrin. We could speculate that hypohidrosis or anhidrosis itself might impair skin barrier function and contribute to atopic diathesis.
authors.affiliation: Department of Dermatology, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
authors.forename: Hanako
authors.initials: H
authors.lastname: Koguchi-Yoshioka
authors.forename: Mari
authors.initials: M
authors.lastname: Wataya-Kaneda
authors.forename: Mizuki
authors.initials: M
authors.lastname: Yutani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Murota
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakano
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sawamura
authors.forename: Ichiro
authors.initials: I
authors.lastname: Katayama
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000150:complications* / Q000378:metabolism; D004476:Ectodermal Dysplasia / Q000150:complications* / Q000378:metabolism; D005260:Female; D000091344:Filaggrin Proteins; D006801:Humans; D007007:Hypohidrosis; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008297:Male; D013194:Staining and Labeling; D013545:Sweat Glands / Q000002:abnormalities; D055815:Young Adult
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D007073:Immunoglobulin E