title: Analysis of clinical prognostic factors for adult patients with head and neck sarcomas.
abstract: OBJECTIVE
  To evaluate the treatment, outcome, and prognostic factors in patients with head and neck sarcomas treated in an academic medical center.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  We performed a retrospective analysis of adult patients (n = 97) with primary head and neck sarcomas treated between 2000 and 2012. We analyzed the treatment, outcome, and potential factors predictive of disease-free survival and disease-specific survival. We also evaluated the outcome and prognostic factors in patients with bone and soft tissue sarcomas.
  
  
  RESULTS
  The median overall survival was 6.8 years, with 2-year and 5-year overall survival rates of 78% (95% confidence interval [CI], 66%-86%) and 59% (95% CI, 44%-72%), respectively. Univariable analysis revealed that age at diagnosis (>60 years: hazard ratio [HR], 2.7; 95% CI, 1.2-6.2; P = .01), surgical intervention (HR, 8.3; 95% CI, 3.5-19.5; P < .001), and metastatic disease (HR, 4.3; 95% CI, 1.3-13.6; P = .01) were significantly associated with disease-specific survival.
  
  
  CONCLUSIONS
  In this study, patients over the age of 60 years at diagnosis and those with inoperable disease at initial presentation had significantly worse disease-specific survival. Surgical intervention remains the optimal treatment modality for those with resectable disease and was associated with significantly better survival in this heterogeneous series. Further multi-institutional studies are required to better define prognostic factors in individual histological subtypes.
authors.affiliation: University of Washington School of Medicine, Seattle, Washington, USA.
authors.forename: Amy E
authors.initials: AE
authors.lastname: Chang
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chai
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA Seattle Cancer Care Alliance, Seattle, Washington, USA.
authors.forename: Seth M
authors.initials: SM
authors.lastname: Pollack
authors.affiliation: Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA Seattle Cancer Care Alliance, Seattle, Washington, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Loggers
authors.affiliation: Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA Seattle Cancer Care Alliance, Seattle, Washington, USA.
authors.forename: Eve
authors.initials: E
authors.lastname: Rodler
authors.affiliation: University of Washington School of Medicine, Seattle, Washington, USA.
authors.forename: Jasjit
authors.initials: J
authors.lastname: Dillon
authors.affiliation: Department of Radiation Oncology, University of Washington Medical Center, Seattle, Washington, USA.
authors.forename: Upendra
authors.initials: U
authors.lastname: Parvathaneni
authors.affiliation: Department of Otolaryngology, University of Washington Medical Center, Seattle, Washington, USA.
authors.forename: Kris S
authors.initials: KS
authors.lastname: Moe
authors.affiliation: Department of Otolaryngology, University of Washington Medical Center, Seattle, Washington, USA.
authors.forename: Neal
authors.initials: N
authors.lastname: Futran
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington, USA Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA Seattle Cancer Care Alliance, Seattle, Washington, USA rjones@seattlecca.org.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Jones
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015331:Cohort Studies; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D018570:Risk Assessment; D012509:Sarcoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
keywords: bone; head and neck; outcome; prognostic factors; sarcoma; soft tissue sarcoma