title: Evidence of LAT1 expression in canine caput epididymis.
abstract: L-type amino acid transporter 1 (LAT1), the first isotype of amino acid transport system L, transports aromatic and branched amino acids pivotal for fundamental cellular activities such cellular growth and proliferation. LAT1 expression was high only in the brain in contrast to its limited distribution and low level of expression in normal tissues. We found potent LAT1 expression in canine caput epididymis by quantitative RT-PCR and Western blotting analysis. Immnuno-histochemical examination revealed observable LAT1 in microvillous epithelial cells.
authors.affiliation: Laboratory of Pathology, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors.forename: Kikumi
authors.initials: K
authors.lastname: Ogihara
authors.forename: Ken
authors.initials: K
authors.lastname: Onda
authors.forename: Reiichiro
authors.initials: R
authors.lastname: Sato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Naya
authors.forename: Hideharu
authors.initials: H
authors.lastname: Ochiai
mesh_terms: D000818:Animals; D004285:Dogs / Q000502:physiology*; D004822:Epididymis / Q000033:anatomy & histology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology*; D007150:Immunohistochemistry; D027283:Large Neutral Amino Acid-Transporter 1 / Q000235:genetics / Q000378:metabolism*; D008297:Male
chemical_list: D027283:Large Neutral Amino Acid-Transporter 1