title: Nuclear imaging to support anti-inflammatory drug discovery and development.
abstract: Nuclear medicine contributes important tools to support anti-inflammatory drug discovery and development. The support provided is manifold: new molecular entities (NME, either small molecules or biologics) labeled with radioisotopes can be applied in animal models and humans to measure biodistribution, target engagement, and pharmacokinetics. In addition, nuclear imaging techniques can be used to select or enrich the patient populations in clinical trials, to assess disease activity, target status and distribution and to quantify response to therapeutic interventions. In the first part of this review we will outline how nuclear imaging techniques can be applied to support informed decision making in drug development. In the second part, we will briefly high-light the use of nuclear imaging of inflammation in drug development in selected diseases, specifically rheumatoid arthritis (RA), inflammatory bowel diseases (IBD), atherosclerosis and - as an emerging topic - cancer.
authors.affiliation: Boehringer Ingelheim Pharma GmbH & Co. KG Translational Medicine and Clinical Pharmacology Biberach an der Riss, Germany - andreas.wunder@boehringer-ingelheim.com.
authors.forename: A
authors.initials: A
authors.lastname: Wunder
authors.forename: A
authors.initials: A
authors.lastname: Thiele
authors.forename: M
authors.initials: M
authors.lastname: Koslowski
authors.forename: F
authors.initials: F
authors.lastname: Gantner
authors.forename: H
authors.initials: H
authors.lastname: Niessen
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D007553:Isotope Labeling / Q000379:methods; D017063:Outcome Assessment, Health Care / Q000379:methods*; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D019275:Radiopharmaceuticals