title: Aptamer-functionalized barcode particles for the capture and detection of multiple types of circulating tumor cells.
abstract: Aptamer-functionalized barcode particles are employed to capture and detect various types of circulating tumor cells (CTCs). The particles are spherical colloidal crystal clusters, and the reflection properties that arise from their structures are how their codes are evaluated. Aptamer functionalization (with TD05, Sgc8, and Sgd5) make the particles interact with specific CTC types; dendrimers are used to amplify the effect of the aptamers, allowing for increased sensitivity, reliability, and specificity in CTC capture, detection, and subsequent release.
authors.affiliation: State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China.
authors.forename: Fuyin
authors.initials: F
authors.lastname: Zheng
authors.forename: Yao
authors.initials: Y
authors.lastname: Cheng
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Yuanjin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhongze
authors.initials: Z
authors.lastname: Gu
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D045744:Cell Line, Tumor; D002469:Cell Separation / Q000379:methods*; D050091:Dendrimers / Q000737:chemistry; D006801:Humans; D007938:Leukemia / Q000175:diagnosis; D017493:Leukocyte Common Antigens / Q000737:chemistry; D007962:Leukocytes / Q000737:chemistry; D008223:Lymphoma / Q000737:chemistry / Q000175:diagnosis; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D009360:Neoplastic Cells, Circulating / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D052157:Aptamers, Nucleotide; D050091:Dendrimers; D012822:Silicon Dioxide; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human
keywords: aptamers; biomedical applications; colloidal crystals; dendrimers; tumor cells