title: Relation of early post-stress left ventricular dyssynchrony and the extent of angiographic coronary artery disease.
abstract: BACKGROUND
  Previous studies showed different dyssynchrony patterns between ischemic and normal myocardium at early post-stress using Tl-201 gated SPECT myocardial perfusion imaging (MPI). The aim of this study was to assess the relation of stress-induced dyssynchrony and the extent of angiographic coronary artery disease (CAD).
  
  
  RESULTS
  The MPI images of 144 patients were retrospectively analyzed. With ≥70% stenosis as the criteria of CAD, 57 had no CAD, 32 had 1-vessel disease, 36 had 2-vessel disease, and 19 had 3-vessel disease, respectively. LV global and territorial dyssynchrony parameters were measured by the phase analysis from stress/rest Tl-201 SPECT MPI and compared between stress and rest among the patient groups. The patients with multi-vessel CAD had significantly more global dyssynchrony than the patients without ≥70% stenosis at stress. The patients with multi-vessel CAD showed significantly more global and territorial dyssynchrony on stress images than on rest. More patients with 3-vessel CAD were correctly classified as multi-vessel disease, when combining both visual interpretation and dyssynchrony assessment.
  
  
  CONCLUSIONS
  The patients with multi-vessel CAD had significantly more global and territorial dyssynchrony at early post-stress than at rest. Such quantitative measures of myocardial stunning may assist in the diagnosis of multi-vessel CAD.
authors.affiliation: Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Huang
authors.forename: Ching-Hui
authors.initials: CH
authors.lastname: Huang
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Lee
authors.forename: Ching-Pei
authors.initials: CP
authors.lastname: Chen
authors.forename: Guang-Uei
authors.initials: GU
authors.lastname: Hung
authors.forename: Ji
authors.initials: J
authors.lastname: Chen
mesh_terms: D000368:Aged; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000175:diagnosis*; D005080:Exercise Test / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology
chemical_list: D019275:Radiopharmaceuticals; D013794:Thallium Radioisotopes