title: TRAF6 is over-expressed in pancreatic cancer and promotes the tumorigenicity of pancreatic cancer cells.
abstract: Pancreatic cancer is one of the most lethal malignancies, with a poor response to chemotherapy and therefore it is important to identify novel therapeutic targets. TNF receptor-associated factor 6 (TRAF6) , a regulator of NF-κB signaling, has been found recently to be involved in tumorigenesis. However, its function in pancreatic cancer remains poorly understood. Here, we found that the expression of TRAF6 was up-regulated in pancreatic cancer tissues. Moreover, over-expression of TRAF6 in pancreatic cancer cells promoted cell proliferation and migration, whereas down-regulation of TRAF6 impaired the tumorigenicity of pancreatic cancer cells in vitro and in vivo. Mechanistically, TRAF6 regulated the expression of multiple genes involved in cell growth, apoptosis and migration. Our results suggested several important roles of TRAF6 in the pathogenesis of pancreatic cancer. TRAF6 might therefore represent a potential therapeutic target.
authors.affiliation: Pancreatic Cancer Group, General Surgery Department, Zhongshan Hospital, Fudan University, Fenlin Rd No. 180, Shanghai, 200032, People's Republic of China.
authors.forename: Yefei
authors.initials: Y
authors.lastname: Rong
authors.forename: Dansong
authors.initials: D
authors.lastname: Wang
authors.forename: Wenchuan
authors.initials: W
authors.lastname: Wu
authors.forename: Dayong
authors.initials: D
authors.lastname: Jin
authors.forename: Tiantao
authors.initials: T
authors.lastname: Kuang
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Ni
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Wenhui
authors.initials: W
authors.lastname: Lou
mesh_terms: D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D048029:TNF Receptor-Associated Factor 6 / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D048029:TNF Receptor-Associated Factor 6