title: Kinetic modeling in PET imaging of hypoxia.
abstract: Tumor hypoxia is associated with increased therapeutic resistance leading to poor treatment outcome. Therefore the ability to detect and quantify intratumoral oxygenation could play an important role in future individual personalized treatment strategies. Positron Emission Tomography (PET) can be used for non-invasive mapping of tissue oxygenation in vivo and several hypoxia specific PET tracers have been developed. Evaluation of PET data in the clinic is commonly based on visual assessment together with semiquantitative measurements e.g. standard uptake value (SUV). However, dynamic PET contains additional valuable information on the temporal changes in tracer distribution. Kinetic modeling can be used to extract relevant pharmacokinetic parameters of tracer behavior in vivo that reflects relevant physiological processes. In this paper, we review the potential contribution of kinetic analysis for PET imaging of hypoxia.
authors.affiliation: Cluster for Molecular Imaging, University of Copenhagen Blegdamsvej 3, 2200 Copenhagen, Denmark ; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: Cluster for Molecular Imaging, University of Copenhagen Blegdamsvej 3, 2200 Copenhagen, Denmark ; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Jesper T
authors.initials: JT
authors.lastname: Joergensen
authors.affiliation: Cluster for Molecular Imaging, University of Copenhagen Blegdamsvej 3, 2200 Copenhagen, Denmark ; Department of Micro- and Nanotechnology, Center for Nanomedicine and Theranostics, DTU Nanotech, Technical University of Denmark Building 423, 2800 Lyngby, Denmark.
authors.forename: Anders E
authors.initials: AE
authors.lastname: Hansen
authors.affiliation: Cluster for Molecular Imaging, University of Copenhagen Blegdamsvej 3, 2200 Copenhagen, Denmark ; Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, University of Copenhagen Blegdamsvej 9, 2100 Copenhagen, Denmark.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
keywords: 18F-FAZA; 18F-FETNIM; 18F-FMISO; Cu-ATSM; oxygenation