title: Pollen Typhae total flavone improves insulin resistance in high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats.
abstract: Pollen Typhae total flavone (PTF), the extract from Pollen Typhae, is reported to enhance glucose uptake in C2C12 myotubes in vitro, but the convincing evidence is lacking in vivo. In this study, PTF ameliorated insulin resistance and dyslipidemia, but failed to significantly increase body weight in type 2 diabetic rats induced by high-fat diet and low-dose streptozotocin.
authors.affiliation: a Guangxi Scientific Experimental Center for Traditional Chinese Medicine , Guangxi University of Chinese Medicine , Nanning , China.
authors.forename: Xiao-Tao
authors.initials: XT
authors.lastname: Feng
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xie
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.forename: Ze-Hui
authors.initials: ZH
authors.lastname: Jiang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Leng
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D059305:Diet, High-Fat / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D047309:Flavones / Q000494:pharmacology* / Q000627:therapeutic use; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D051381:Rats; D032401:Typhaceae / Q000737:chemistry*
chemical_list: D047309:Flavones; D008055:Lipids; C043562:flavone
keywords: dyslipidemia; glucose tolerance; insulin resistance; traditional Chinese medicine; type 2 diabetes