title: Preoperative differential diagnosis between intrahepatic biliary cystadenoma and cystadenocarcinoma: a single-center experience.
abstract: OBJECTIVE
  To investigate preoperative differential diagnoses made between intrahepatic biliary cystadenoma and intrahepatic biliary cystadenocarcinoma.
  
  
  METHODS
  A retrospective analysis of patient data was performed, which included 21 cases of intrahepatic biliary cystadenoma and 25 cases of intrahepatic biliary cystadenocarcinoma diagnosed between April 2003 and April 2013 at the General Hospital of PLA. Potential patients were excluded whose diagnoses were not confirmed pathologically. Basic information (including patient age and gender), clinical manifestation, duration of symptoms, serum assay results (including tumor markers and the results of liver function tests), radiological features and pathological results were collected. All patients were followed up.
  
  
  RESULTS
  Preoperative levels of cancer antigen 125 (12.51 ± 9.31 vs 23.20 ± 21.86, P < 0.05) and carbohydrate antigen 19-9 (22.56 ± 26.30 vs 72.55 ± 115.99, P < 0.05) were higher in the cystadenocarcinoma subgroup than in the cystadenoma subgroup. There were no statistically significant differences in age or gender between the two groups, or in pre- or post-operative levels of alanine aminotransferase, aspartate aminotransferase, total bilirubin (TBIL), and direct bilirubin (DBIL) between the two groups. However, eight of the 21 patients with cystadenoma and six of the 25 patients with cystadenocarcinoma had elevated levels of TBIL and DBIL. There were three cases in the cystadenoma subgroup and six cases in the cystadenocarcinoma subgroup with postoperative complications.
  
  
  CONCLUSIONS
  Preoperative differential diagnosis relies on the integration of information, including clinical symptoms, laboratory findings and imaging results.
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Fu-Bo
authors.initials: FB
authors.lastname: Zhang
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Zhang
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Zhang
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Xi-Tao
authors.initials: XT
authors.lastname: Wang
authors.affiliation: Fu-Bo Zhang, Ai-Min Zhang, Zhi-Bin Zhang, Xin Huang, Xi-Tao Wang, Jia-Hong Dong, Department of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Dong
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D001653:Bile Ducts, Intrahepatic / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D001774:Blood Chemical Analysis; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002681:China; D003536:Cystadenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006769:Hospitals, General; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D011237:Predictive Value of Tests; D057234:Preoperative Period; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D001663:Bilirubin
keywords: Intrahepatic biliary cystadenocarcinoma; Intrahepatic biliary cystadenoma; Preoperative differential diagnosis