title: Complications of immunosuppressive agents therapy in transplant patients.
abstract: Solid organ transplantation remains the gold standard for the treatment of end-stage organ dysfunction and saves thousands of lives. Besides the progress of surgery, advances in understanding transplant physiology, immunology and the development of immunosuppressive drugs lead to improved short- and long-term survival. Transplantation is offered to an increasing number of patients with higher age and comorbidities. Approximately one third of organ recipients require hospital readmission after transplantation because of a multitude of clinical problems related to immunosuppressive therapy. We review the current knowledge on typical complications associated with immunosuppressants with emphasis on the intensivist's perspective.
authors.affiliation: Fachkrankenhaus Coswig GmbH, Division of Anesthesiology and Intensive Care Medicine, Coswig, Germany - michael.metze@web.de.
authors.forename: A
authors.initials: A
authors.lastname: Reske
authors.forename: A
authors.initials: A
authors.lastname: Reske
authors.forename: M
authors.initials: M
authors.lastname: Metze
mesh_terms: D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007239:Infections / Q000453:epidemiology; D016377:Organ Transplantation; D014181:Transplantation Immunology
chemical_list: D007166:Immunosuppressive Agents