title: Performance of MDRD-IDMS and CKD-EPI equations in Mexican individuals with normal renal function.
abstract: BACKGROUND
  &nbsp;The performance of the CKD-EPI and MDRD formulae for estimating glomerular filtration rate (GFR) in patients of Hispanic origin with normal renal function has been poorly explored and requires validation in Mexico.&nbsp;
  
  
  METHODS
  &nbsp;We included previously healthy Mexican adults. We obtained clinical variables and determined serum creatinine to calculate the CKD-EPI and MDRD-IDMS formulae. These results were compared with the gold standard (GFR measured by Tc99DTPA). We evaluated other clinical variables that could affect the performance of the CKD-EPI formula.&nbsp;
  
  
  RESULTS
  &nbsp;A total of 97 healthy volunteers were included, 55 males and 42 females; the mean age was 35.8 years old (18 to 73). Mean creatinine was 0.76mg/dl (&plusmn;0.18). CKD-EPI performance was significantly better than MDRD-IDMS in all comparisons (bias, correlation and accuracy). The bias difference between the formulae was 6.08ml/min/1.73m2&nbsp;(95% CI 2.58 to 9.58) (p&lt;.001). Individuals with a body mass index (BMI) above 25kg/m2&nbsp;displayed a better performance than the group with a lower BMI (difference of means 7.39ml/min/1.73m2;&nbsp;95% CI 1.17 to 13.6 p&lt;.02). Both formulae overestimated the GFR. BMI was significantly associated with the performance of the CKD-EPI formula (&beta; 0.82; 95% CI 0.085 to 1.56 p=.029).&nbsp;
  
  
  CONCLUSIONS
  &nbsp;In healthy Mexican adults, the CKD-EPI formula is a better predictor of the mGFR than the MDRD-IDMS formula. BMI is significantly associated with the performance of the CKD-EPI formula and is better in those with a BMI greater than 25kg/m2. Both formulae overestimate mGFR.
authors.forename: José M
authors.initials: JM
authors.lastname: Arreola-Guerra
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Rincón-Pedrero
authors.forename: Cristino
authors.initials: C
authors.lastname: Cruz-Rivera
authors.forename: Teresa
authors.initials: T
authors.lastname: Belmont-Pérez
authors.forename: Ricardo
authors.initials: R
authors.lastname: Correa-Rotter
authors.forename: José A
authors.initials: JA
authors.lastname: Niño-Cruz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008297:Male; D055641:Mathematical Concepts; D008800:Mexico; D008875:Middle Aged; D012016:Reference Values; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis; D055815:Young Adult