title: Enhanced cell adhesion to the dimpled surfaces of golf-ball-shaped microparticles.
abstract: Engineering surface morphology as in honeycomb-structured planar films is of great importance for providing new potential application and improved performance in biomedical fields. We demonstrate potential new applications for the uniform biocompatible golf-ball-shaped microparticles that resembles 3D feature of honeycomb-structured film. Dimple size controllable golf-ball-shaped microparticles were fabricated by microfluidic device. Surface dimples not only can act as picoliter beaker but also enhance cell adhesion without any chemical modification of the surface.
authors.affiliation: Division of Advanced Materials Engineering, Kongju National University , 1223-24, Cheonan-daero, Seobuk-gu, Cheonan, Chungnam 331-717, Korea.
authors.forename: Joo Hyuk
authors.initials: JH
authors.lastname: Lee
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Kuk Young
authors.initials: KY
authors.lastname: Cho
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D003460:Crystallization; D057809:HEK293 Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000494:pharmacology*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012965:Sodium Chloride / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D012965:Sodium Chloride
keywords: biodegradable polymer; cell adhesion; drug release; golf-ball-shape; microparticle; surface morphology