title: 8q24 risk alleles and prostate cancer in African-Barbadian men.
abstract: BACKGROUND
  African American men (AA) exhibit a disproportionate share of prostate cancer (PRCA) incidence, morbidity, and mortality. Several genetic association studies have implicated select 8q24 loci in PRCA risk in AA. The objective of this investigation is to evaluate the association between previously reported 8q24 risk alleles and PRCA in African-Barbadian (AB) men known to have high rates of PRCA.
  
  
  METHODS
  Ten previously reported candidate tag SNPs were genotyped and/or imputed in the 8q24 region in 532 AB men with PRCA and 513 AB controls from the Prostate Cancer in a Black Population (PCBP) study.
  
  
  RESULTS
  Rs2124036 was significant in AB men, (OR = 2.7, 95% CI (1.3-5.3), P = 0.005, Empirical (max (T), corrected for multiple testing) P = 0.03) for the homozygous C/C genotype. Only a single SNP from this region remained statistically significant in our analysis of our AB population. These results may indicate the presence of a founder effect or due to the chosen SNPs not tagging an ancestral haplotype bearing the 8q24 risk allele(s) in this population or could reflect inadequate power to detect an association. We conducted a meta-analysis including our AB population along with two additional African Caribbean populations from Tobago and Jamaica for SNPs rs16901979 and rs1447295. Meta-analysis results were most significant for rs16901979 A allele (Z score 2.73; P = 0.006) with a summary OR = 1.31 (95% CI: 1.09-1.58).
  
  
  CONCLUSIONS
  Additional studies are needed to provide deeper genotype coverage to further interrogate the 8q24 region to understand its contribution to PRCA in this population.
authors.affiliation: Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, Maryland.
authors.forename: Cheryl D
authors.initials: CD
authors.lastname: Cropp
authors.forename: Christiane M
authors.initials: CM
authors.lastname: Robbins
authors.forename: Xin
authors.initials: X
authors.lastname: Sheng
authors.forename: Anselm J M
authors.initials: AJ
authors.lastname: Hennis
authors.forename: John D
authors.initials: JD
authors.lastname: Carpten
authors.forename: Lyndon
authors.initials: L
authors.lastname: Waterman
authors.forename: Ronald
authors.initials: R
authors.lastname: Worrell
authors.forename: Tae-Hwi
authors.initials: TH
authors.lastname: Schwantes-An
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Trent
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: M Cristina
authors.initials: MC
authors.lastname: Leske
authors.forename: Suh-Yuh
authors.initials: SY
authors.lastname: Wu
authors.forename: Joan E
authors.initials: JE
authors.lastname: Bailey-Wilson
authors.forename: Barbara
authors.initials: B
authors.lastname: Nemesure
mesh_terms: D000349:Africa / Q000208:ethnology; D000483:Alleles; D001460:Barbados / Q000453:epidemiology; D017691:Caribbean Region / Q000453:epidemiology; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors
keywords: 8q24; Caribbean and risk factors; association; genetic; prostate cancer