title: Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population.
abstract: BACKGROUND
  Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population.
  
  
  METHODS
  Using 2005-2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender.
  
  
  RESULTS
  Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women.
  
  
  CONCLUSIONS
  PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs.
authors.affiliation: Cancer Center, School of Public Health, West Virginia University, Morgantown, WV 265050-9190, USA; Department of Epidemiology and Statistics, School of Public Health, Hebei United University, Hebei 063000, PR China.
authors.forename: Hongmin
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, West Virginia University, USA; Department of Medicine, School of Medicine, West Virginia University, USA; Clinical Translational Science Institute, West Virginia University, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Ducatman
authors.affiliation: Department of Biostatistics, School Public Health, West Virginia University, USA.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D004785:Environmental Pollutants / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D005466:Fluorocarbons / Q000097:blood* / Q000493:pharmacokinetics; D005878:Gilbert Disease / Q000097:blood / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D009820:Ohio; D010641:Phenotype; D012737:Sex Factors; D012907:Smoking; D012959:Socioeconomic Factors; D014903:West Virginia
chemical_list: D004785:Environmental Pollutants; D005466:Fluorocarbons
keywords: Bilirubin; Gilbert syndrome; Perfluorocarbon; Perfluorohexanoic acid (PFHxA); Perfluorooctanesulfonate (PFOS); Perfluorooctanoic acid (PFOA)