title: Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules.
abstract: A review of the synthesis of natural products and bioactive compounds adopting phosphonamide anion technology is presented highlighting the utility of phosphonamide reagents in stereocontrolled bond-forming reactions. Methodologies utilizing phosphonamide anions in asymmetric alkylations, Michael additions, olefinations, and cyclopropanations will be summarized, as well as an overview of the synthesis of the employed phosphonamide reagents.
authors.affiliation: Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.
authors.forename: Thilo
authors.initials: T
authors.lastname: Focken
authors.affiliation: Department of Chemistry, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, QC H3C 3J7, Canada.
authors.forename: Stephen
authors.initials: S
authors.lastname: Hanessian
keywords: conjugate addition; cyclopropanation; olefination; organophosphorus; phosphonamide; total synthesis