title: Prior regular exercise prevents synaptic plasticity impairment in sleep deprived female rats.
abstract: Previous studies have indicated that physical exercise plays a preventive role in synaptic plasticity deficits in the hippocampus of sleep-deprived male rats. The objective of the present study was to evaluate the effects of treadmill running on early long term potentiation (E-LTP) at the Cornu Ammonis (CA1) area of the hippocampus in sleep-deprived female rats. Intact and ovariectomiezed (OVX) female Wistar rats were used in the present study. The exercise protocol was four weeks treadmill running and the multiple platform method was applied to induce 72 h sleep deprivation (SD). We examine the effect of exercise and/or SD on synaptic plasticity using in vivo extracellular recording in the CA1 area of the hippocampus. The field excitatory post-synaptic potential (fEPSP) slope was measured before and 2h after high frequency stimulation (HFS) in the experimental groups. Field potential recording indicated that the induction and maintenance phase of E-LTP impaired in the sleep deprived animals compared to the other groups. After 72 h SD, E-LTP impairments were prevented by 4 weeks of regular treadmill exercise. In conclusion, the synaptic plasticity deficit in sleep-deprived female rats was improved by regular physical exercise. Further studies are suggested to evaluate the possible underlying mechanisms.
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: hsadat54@yahoo.com.
authors.forename: Hakimeh
authors.initials: H
authors.lastname: Saadati
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran; Department of Physiology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: vsheibani2@yahoo.com.
authors.forename: Vahid
authors.initials: V
authors.lastname: Sheibani
authors.affiliation: Department of Biology, Faculty of Science, Shahid Bahonar University, Kerman, Iran. Electronic address: Semahani@yahoo.com.
authors.forename: Saeed
authors.initials: S
authors.lastname: Esmaeili-Mahani
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: Vhajali@yahoo.com.
authors.forename: Vahid
authors.initials: V
authors.lastname: Hajali
authors.affiliation: Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: Shahrzadmz@yahoo.com.
authors.forename: Shahrzad
authors.initials: S
authors.lastname: Mazhari
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials; D005260:Female; D017774:Long-Term Potentiation; D010052:Ovariectomy; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000503:physiopathology*
keywords: Female rat; Long term potentiation; Physical exercise; Sleep deprivation