title: Location of Irritative Zone in Epileptic Brains of Schizencephalic Patients.
abstract: Although many schizencephaly patients suffer from epilepsy, the relationship between schizencephalic lesions and epileptic foci remains unclear. Previous studies have shown that schizencephalic lesions may be associated with, rather than contain, epileptogenic zones. Thus, the purpose of this study was to investigate the current source distribution (CSD) of epileptiform discharges in schizencephalic patients and to correlate this activity with existing structural lesions. A consecutive series of 30 schizencephalic patients who were diagnosed using brain magnetic resonance imaging (MRI) were selected retrospectively and prospectively. Of the original 30 subjects selected, 13 had epilepsy, and 6 of these patients exhibited schizencephaly, epilepsy, and interictal spikes on electroencephalograms (EEG) and were enrolled in the present study investigating the current source analysis of interictal spikes. The CSDs of the initial rising phases and the peak points of the interictal spikes were obtained using standardized low-resolution brain electromagnetic tomography (LORETA). Five patients exhibited a single focus of interictal spikes, while 1 patient showed 2 foci. Relative to the structural brain lesions, 5 patients displayed extrinsically localized CSDs, while 1 patient showed a partially intrinsically localized CSD. The present findings demonstrate that the CSDs of interictal spikes in schizencephalic patients are in general anatomically distinct from the cerebral schizencephalic lesions and that these lesions may display an extrinsic epileptogenicity.
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Do-Hyung
authors.initials: DH
authors.lastname: Kim
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea mnkwon21@hanmail.net.
authors.forename: Oh-Young
authors.initials: OY
authors.lastname: Kwon
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Suck-Won
authors.initials: SW
authors.lastname: Jung
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Heejeong
authors.initials: H
authors.lastname: Jeong
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Seongnam
authors.initials: S
authors.lastname: Son
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Soo-Kyoung
authors.initials: SK
authors.lastname: Kim
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Heeyoung
authors.initials: H
authors.lastname: Kang
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Ki-Jong
authors.initials: KJ
authors.lastname: Park
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: Nack-Cheon
authors.initials: NC
authors.lastname: Choi
authors.affiliation: Department of Neurology and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.
authors.forename: ByeongHoon
authors.initials: B
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D015203:Reproducibility of Results; D065707:Schizencephaly / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: electroencephalography; epilepsy; low-resolution electrical tomographic analysis; schizencephaly; seizures