title: Immediate complications associated with high-flow cerebrospinal fluid egress during endoscopic endonasal skull base surgery.
abstract: Endoscopic expanded endonasal approaches (EEAs) to the skull base are increasingly being used to address a variety of skull base pathologies. Postoperative CSF leakage from the large skull base defects has been well described as one of the most common complications of EEAs. There are reports of associated formation of delayed subdural hematoma and tension pneumocephalus from approximately 1 week to 3 months postoperatively. However, there have been no reports of immediate complications of high-volume CSF leakage from EEA skull base surgery. The authors describe two cases of EEAs in which complications related to rapid, large-volume CSF egress through the skull base surgical defect were detected in the immediate postoperative period. Preventive measures to reduce the likelihood of these immediate complications are presented.
authors.affiliation: Departments of Neurological Surgery, Wexner Medical Center, The Ohio State University College of Medicine, Columbus, Ohio.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Kerr
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Prevedello
authors.forename: Ali
authors.initials: A
authors.lastname: Jamshidi
authors.forename: Leo F
authors.initials: LF
authors.lastname: Ditzel Filho
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Otto
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Carrau
mesh_terms: D000236:Adenoma / Q000601:surgery; D000368:Aged; D000369:Aged, 80 and over; D065634:Cerebrospinal Fluid Leak / Q000209:etiology*; D004724:Endoscopy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D009666:Nose / Q000601:surgery*; D010911:Pituitary Neoplasms / Q000601:surgery; D011183:Postoperative Complications; D019291:Skull Base / Q000601:surgery*; D015898:Tomography Scanners, X-Ray Computed
keywords: EEA = endoscopic expanded endonasal approach; EVD = external ventricular drain; RCH = remote cerebellar hemorrhage; SDH = subdural hematoma; SSEP = somatosensory evoked potential; TFF = temporoparietal fascia flap; TP = tension pneumocephalus; cerebrospinal fluid leakage; endoscopic endonasal approach; expanded endonasal approach; skull base defect; subdural hematoma; tension pneumocephalus