title: Oral Human Papillomavirus (HPV) Infection among Unvaccinated High-Risk Young Adults.
abstract: Oral HPV infection, the cause of most oropharyngeal cancer in the U.S., is not well studied among high-risk young adults. Men (n = 340) and women (n = 270) aged 18-25 years attending Baltimore County STD clinics were recruited if they declined HPV vaccination. Each participant had a 30-second oral rinse and gargle sample tested for 37 types of HPV DNA, and a risk-factor survey. Factors associated with prevalent infection were explored using log binomial regression. Men had higher prevalence of any oral HPV (15.3% vs. 7.8%, p = 0.004) and vaccine-type oral HPV (i.e., HPV16/18/6/11: 5.0% vs. 1.1%, p = 0.007) infection than women. In multivariate analysis, male gender (aPR = 1.93, 95% CI = 1.10-3.39), number of recent oral sex partners (p-trend = 0.013) and having ever performed oral sex on a woman (aPR = 1.73, 95% CI = 1.06-2.82) were associated with increased oral HPV prevalence. Performing oral sex on a woman may confer higher risk of oral HPV acquisition than performing oral sex on a man.
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. gdsouza2@jhu.edu.
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: D'Souza
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. nkluz1@jhu.edu.
authors.forename: Nicole
authors.initials: N
authors.lastname: Kluz
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. awentz2@jhmi.edu.
authors.forename: Alicia
authors.initials: A
authors.lastname: Wentz
authors.affiliation: Baltimore County Health Department, Baltimore, MD 21212, USA. ryoungfellow@baltimorecountymd.gov.
authors.forename: Renee M
authors.initials: RM
authors.lastname: Youngfellow
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. anniegriffioen@gmail.com.
authors.forename: Anne
authors.initials: A
authors.lastname: Griffioen
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. estammer@gmail.com.
authors.forename: Emily
authors.initials: E
authors.lastname: Stammer
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA. Yingshi.Guo@osumc.edu.
authors.forename: Yingshi
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA. Weihong.Xiao@osumc.edu.
authors.forename: Weihong
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Ohio State University Comprehensive Cancer Center, Columbus, OH 43202, USA. maura.gillison@osumc.edu.
authors.forename: Maura L
authors.initials: ML
authors.lastname: Gillison