title: Aspergillomarasmine A, an inhibitor of bacterial metallo-β-lactamases conferring blaNDM and blaVIM resistance.
abstract: Silencing the deadly "bla-bla" of superbugs: The natural product aspergillomarasmine A (AMA) showed in vivo efficacy against Enterobacteriaceae, conferring broad β-lactam resistance blaNDM-1 (NDM-1: New Delhi Metallo-β-lactamase 1). In rodents, the natural product restored efficacy of the gold standard meropenem by inhibition of the Zn-containing active site in NDM-1.
authors.affiliation: Global Drug Discovery, Bayer HealthCare. franz.nussbaum@bayer.com.
authors.forename: Franz
authors.initials: F
authors.lastname: von Nussbaum
authors.forename: Guido
authors.initials: G
authors.lastname: Schiffer
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D015780:Carbapenems / Q000494:pharmacology*; D005260:Female; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*; D018440:beta-Lactam Resistance / Q000187:drug effects*; D065093:beta-Lactamase Inhibitors
chemical_list: D015780:Carbapenems; D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D001224:Aspartic Acid
keywords: amino acids; antibiotics; lactams; natural products; zinc