title: [Application of CADD on multi-target drug R&D in natural products].
abstract: Multi-target drugs can simultaneously adjust multiple links of the disease network. Despite the higher efficacy and lower toxicity caused by single targets, multi-target drugs become ideal drugs for treating complicated diseases as well the main direction of drug R & D. By virtue of their structural diversity, higher multi-target activity and lower toxicity, natural products become an important source for developing multi-target drugs. Computer-aided drug design (CADD) is a commonly used multi-target drug R&D method, which mainly includes virtual screening and pharmacophore design. In this paper, the authors made a systematical analysis and discussed the prospects and advantages of various methods for multi-target drug R&D with natural products.
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Qiao
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000494:pharmacology*; D035843:Biomedical Research / Q000295:instrumentation; D017076:Computer-Aided Design; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy
chemical_list: D001688:Biological Products