title: The role of coupled resistance-compliance in upper tracheobronchial airways under high frequency oscillatory ventilation.
abstract: A large eddy simulation (LES) based computational fluid dynamics (CFD) study was conducted to investigate lung lobar ventilation and gas exchange under high frequency oscillatory ventilation conditions. Time-dependent pressure coupled with the airways resistance and compliance (R&C) were imposed as boundary conditions (BCs) in the upper tracheobronchial tree of patient-specific lung geometry. The flow distribution in the left and right lungs demonstrated significant variations compared to the case in which traditional BCs based on mass flow rate fractions was used and is in agreement with the in vivo data available in the literature. The gas transport due to the pendelluft mechanism was captured in the different lung lobes and units. The computed pendelluft elapsed time was consistent with available physiological data. In contrast to in vivo studies, our simulations were able to predict the volume associated with the pendelluft elapsed time at different frequencies. Significant differences in coaxial counter flow and flow structures were observed between different BCs. The consistency of the results with the physiological in vivo data indicates that computations with coupled R&C BCs provide a suitable alternative tool for understanding the gas transport, diagnosing lung pathway disease severity, and optimizing ventilation management techniques.
authors.affiliation: Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA 18015, United States.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Alzahrany
authors.affiliation: Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA 18015, United States. Electronic address: arb612@lehigh.edu.
authors.forename: Arindam
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: Respiratory and Critical Care Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, United States.
authors.forename: Gary
authors.initials: G
authors.lastname: Salzman
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D000465:Algorithms; D003198:Computer Simulation; D006612:High-Frequency Ventilation; D006801:Humans; D057446:Hydrodynamics; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008176:Lung Volume Measurements; D008954:Models, Biological; D011312:Pressure; D011659:Pulmonary Gas Exchange / Q000502:physiology; D013995:Time
keywords: High frequency ventilation; Physiological boundary conditions