title: Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.
abstract: Accumulating evidence has revealed that a natural compound curcumin exerts its anti-tumor activity in pancreatic cancer. However, the underlying molecular mechanism remains elusive. Recently, miRNAs have been demonstrated to play a crucial role in tumorigenesis, suggesting that targeting miRNAs could be a promising approach for the treatment of human cancers. In this study, we explored whether curcumin regulates miR-7, leading to the inhibition of cell growth, migration and invasion in pancreatic cancer cells. We observed that curcumin suppressed cell growth, migration and invasion, and induced cell apoptosis, which is associated with increased expression of miR-7 and subsequently decreased expression of SET8, one of the miR-7 targets. These findings demonstrated that targeting miR-7 by curcumin could be a novel strategy for the treatment of pancreatic cancer.
authors.affiliation: Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Donghai Avenue, Anhui 233030, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Ma
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Fang
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Fanpeng
authors.initials: F
authors.lastname: Zeng
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Haijie
authors.initials: H
authors.lastname: Pang
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Donghai Avenue, Anhui 233030, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, China.
authors.forename: Xueping
authors.initials: X
authors.lastname: Wu
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Research Center of Clinical Laboratory Science, Bengbu Medical College, Anhui 233030, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Ma
authors.affiliation: Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Donghai Avenue, Anhui 233030, China. Electronic address: xiajunbbmc@126.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Xia
authors.affiliation: The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital, Soochow University, Suzhou 215123, China. Electronic address: zhiwei@gmail.com.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003474:Curcumin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D012333:RNA, Messenger / Q000378:metabolism; D014162:Transfection; D015854:Up-Regulation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003474:Curcumin; D011495:Histone-Lysine N-Methyltransferase; D035683:MicroRNAs; D012333:RNA, Messenger; C549242:MIRN7-1 microRNA, human; C470730:KMT5A protein, human
keywords: Apoptosis; Cell growth; Curcumin; Pancreatic cancer; SET8; miR-7