title: Lipidomics reveals dysfunctional glycosynapses in schizophrenia and the G72/G30 transgenic mouse.
abstract: BACKGROUND
  Abnormal structural/functional connectivity has been proposed to underlie the pathophysiology of schizophrenia. However, the biochemical basis of abnormal connectivity remains undefined.
  
  
  METHODS
  We undertook a shotgun lipidomic analysis of over 700 lipids across 26 lipid subclasses in the frontal cortex of schizophrenia subjects and hippocampus of G72/G30 transgenic mice.
  
  
  RESULTS
  We demonstrate that glycosphingolipids and choline plasmalogens, structural lipid pools in myelin, are significantly elevated in the frontal cortex obtained from patients suffering from schizophrenia and the hippocampus of G72/G30 transgenic mice.
  
  
  CONCLUSIONS
  Our data suggest that structural lipid alterations in oligodendrocyte glycosynapses are responsible for dysconnectivity in schizophrenia and that increased expression of G72 protein may play a role in the development of abnormal glycosynapses.
authors.affiliation: Metabolomics Unit, Department of Physiology and Pharmacology, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, 6965 Cumberland Gap Pkwy., Harrogate, TN 37752, USA. Electronic address: paul.wood@lmunet.edu.
authors.forename: Paul L
authors.initials: PL
authors.lastname: Wood
authors.affiliation: Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, Munich D-80804, Germany.
authors.forename: Michaela D
authors.initials: MD
authors.lastname: Filiou
authors.affiliation: Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Str. 25, Bonn D-53127, Germany.
authors.forename: David M
authors.initials: DM
authors.lastname: Otte
authors.affiliation: Institute of Molecular Psychiatry, University of Bonn, Sigmund Freud Str. 25, Bonn D-53127, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Zimmer
authors.affiliation: Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, Munich D-80804, Germany.
authors.forename: Christoph W
authors.initials: CW
authors.lastname: Turck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D004195:Disease Models, Animal; D005260:Female; D020022:Genetic Predisposition to Disease; D006028:Glycosphingolipids / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D015810:Linkage Disequilibrium; D050356:Lipid Metabolism / Q000235:genetics; D008055:Lipids / Q000235:genetics; D008297:Male; D013058:Mass Spectrometry; D051379:Mice; D008822:Mice, Transgenic; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D006028:Glycosphingolipids; D047908:Intracellular Signaling Peptides and Proteins; D008055:Lipids
keywords: Dysconnectivity; Glycosynapse; Plasmalogens; Schizophrenia; Sulfatides