title: Association between chlorinated pesticides in the serum of prepubertal Russian boys and longitudinal biomarkers of metabolic function.
abstract: Organochlorine pesticides (OCPs) have been linked to adult metabolic disorders; however, few studies have examined these associations in childhood. We prospectively evaluated the associations of baseline serum OCPs (hexachlorobenzene, β-hexachlorocyclohexane, and p,p'-dichlorodiphenyldichloroethylene) in Russian boys with subsequent repeated measurements of serum glucose, insulin, lipids, leptin, and calculated homeostatic model assessment of insulin resistance (IR). During 2003-2005, we enrolled 499 boys aged 8-9 years in a prospective cohort; 318 had baseline serum OCPs and serum biomarkers measured at ages 10-13 years. Multivariable generalized estimating equation and mediation regression models were used to examine associations and direct and indirect (via body mass index (BMI) (weight (kg)/height (m)(2))) effects of prepubertal OCP tertiles and quintiles with biomarkers. In multivariable models, higher p,p'-dichlorodiphenyldichloroethylene (quintile 5 vs. quintile 1) was associated with lower leptin, with relative mean decreases of 61.8% (95% confidence interval: 48.4%, 71.7%) in models unadjusted for BMI and 22.2% (95% confidence interval: 7.1%, 34.9%) in models adjusted for BMI; the direct effect of p,p'-dichlorodiphenyldichloroethylene on leptin accounted for 27% of the total effect. IR prevalence was 6.6% at ages 12-13 years. Higher hexachlorobenzene (tertile 3 vs. tertile 1) was associated with higher odds of IR in models adjusted for BMI (odds ratio = 4.37, 95% confidence interval: 1.44, 13.28). These results suggest that childhood OCPs may be associated with IR and lower leptin.
authors.forename: Jane S
authors.initials: JS
authors.lastname: Burns
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.forename: Susan A
authors.initials: SA
authors.lastname: Korrick
authors.forename: Russ
authors.initials: R
authors.lastname: Hauser
authors.forename: Oleg
authors.initials: O
authors.lastname: Sergeyev
authors.forename: Boris
authors.initials: B
authors.lastname: Revich
authors.forename: Thuy
authors.initials: T
authors.lastname: Lam
authors.forename: Mary M
authors.initials: MM
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D010575:Pesticides / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006843:Hydrocarbons, Chlorinated; D007328:Insulin; D020738:Leptin; D010575:Pesticides; D014280:Triglycerides; D002784:Cholesterol
keywords: children; insulin resistance; leptin; metabolism; pesticides