title: Elevated concentrations of circulating cytokines and correlations with nerve conduction velocity in human peripheral nerves.
abstract: The purpose of the current study was to quantify the potential relationship between various cytokines and peripheral nerve function in humans, in-vivo. Measures of nerve conduction velocity (NCV) were examined prior to and following the induction of a cytokine spike. A significant negative correlation was found between the change in IL-1ra and the change in NCV at 24h post-exercise (r=-0.65, p=0.02) while a significant positive correlation was found between the change in IL-6 and the change in NCV at 2h post-exercise (r=0.61, p=0.048). It may be possible that different cytokines induce a unique neural influence at elevated concentrations.
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: dallison@brocku.ca.
authors.forename: David J
authors.initials: DJ
authors.lastname: Allison
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: lara.green@brocku.ca.
authors.forename: Lara A
authors.initials: LA
authors.lastname: Green
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: dgabriel@brocku.ca.
authors.forename: David A
authors.initials: DA
authors.lastname: Gabriel
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: broy@brocku.ca.
authors.forename: Brian D
authors.initials: BD
authors.lastname: Roy
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: greig.inglis@brocku.ca.
authors.forename: J Greig
authors.initials: JG
authors.lastname: Inglis
authors.affiliation: Department of Kinesiology, Brock University, St. Catharines, Ontario L2S 3A1, Canada. Electronic address: dditor@brocku.ca.
authors.forename: David S
authors.initials: DS
authors.lastname: Ditor
mesh_terms: D000704:Analysis of Variance; D018501:Antirheumatic Agents / Q000494:pharmacology; D016207:Cytokines / Q000097:blood*; D004558:Electric Stimulation; D015444:Exercise; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000494:pharmacology; D008297:Male; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology*; D010525:Peripheral Nerves / Q000187:drug effects / Q000502:physiology*; D013223:Statistics as Topic; D013997:Time Factors; D055815:Young Adult
chemical_list: D018501:Antirheumatic Agents; D016207:Cytokines; D053590:Interleukin 1 Receptor Antagonist Protein
keywords: Channelopathy; Interleukin-10; Interleukin-1ra; Interleukin-6; Nerve conduction velocity; Tumor necrosis factor-alpha