title: Evaluation of the vasoplegic impact of papaverine in the rat aorta.
abstract: OBJECTIVE
  To identify the degree of vasoplegic affinity of papaverine to rat thoracic aortas following constriction caused by adrenalin, serotonin and potassium chloride in an in-vitro model.
  
  
  METHODS
  The in vitro vasoplegic efficacy of papaverine against adrenalin (10(-5) M), serotonin (5HT) (10(-4) M), and KCI (60 mM) was assessed, using a rat aortic vasospasm model in an organ bath. First, aortic rings were constricted with a submaximal dose of vasoconstrictor agents. The samples were then incubated with papaverine (3 x 10(-4) M) for 20 minutes, followed by readministration of the same vasoconstrictor agents. The first vasospastic response (before papaverine incubation) and the new vasoconstrictor responses (after papaverine incubation) of the vessels were then compared.
  
  
  RESULTS
  The vasoplegic effect of vasoconstrictor agents in decreasing order was observed as adrenalin > KCl > 5HT. This different affinity for the vasoplegic effect is considered to be a temporary impact of the drugs and the maximal inhibition of vasoconstriction was detected for the adrenalin receptor.
  
  
  CONCLUSIONS
  The relevance of the macromolecules is responsible for the permanent efficacy of the drugs. Different degrees of vasoconstriction were also obtained after papaverine administration, which suggests that different responses can occur as a result of different stimulation of receptor modulators.
authors.forename: Celal
authors.initials: C
authors.lastname: Yavuz
authors.forename: Ahmet
authors.initials: A
authors.lastname: Callskan
authors.forename: Oguz
authors.initials: O
authors.lastname: Karahan
authors.forename: Sinan
authors.initials: S
authors.lastname: Demirtas
authors.forename: Suleyman
authors.initials: S
authors.lastname: Yazici
authors.forename: Orkut
authors.initials: O
authors.lastname: Guclu
authors.forename: Soner
authors.initials: S
authors.lastname: Donmez
authors.forename: Recep Oktay
authors.initials: RO
authors.lastname: Peker
authors.forename: Yasar
authors.initials: Y
authors.lastname: Yildirim
authors.forename: Osman
authors.initials: O
authors.lastname: Gokalp
authors.forename: Binali
authors.initials: B
authors.lastname: Mavitas
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D010208:Papaverine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D012701:Serotonin; D011189:Potassium Chloride; D010208:Papaverine; D004837:Epinephrine