title: Non-steroidal anti-inflammatory drugs and risk of venous thromboembolism: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to integrate and examine the association between NSAID use and venous thromboembolism (VTE).
  
  
  METHODS
  We conducted a systematic review and meta-analysis of studies that reported odds ratios, relative risks, hazard ratios or standardized incidence ratios for VTE among NSAID users compared with non-users. Pooled risk ratios and 95% CIs were calculated using a random effects generic inverse variance model.
  
  
  RESULTS
  Six studies with 21 401 VTE events were identified and included in the data analysis. The pooled risk ratio of VTE in NSAID users was 1.80 (95% CI 1.28, 2.52).
  
  
  CONCLUSIONS
  Our study demonstrated a statistically significant increased risk of VTE among NSAID users. This finding has important public health implications given the prevalence of NSAID use in the general population.
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA. p.ungprasert@gmail.com.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
authors.forename: Narat
authors.initials: N
authors.lastname: Srivali
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA. Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
authors.forename: Karn
authors.initials: K
authors.lastname: Wijarnpreecha
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
authors.forename: Prangthip
authors.initials: P
authors.lastname: Charoenpong
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, Cardiac Electrophysiology Unit, Department of Physiology, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand and Department of Internal Medicine, Advocate Illinois Masonic Medical Center, Chicago, IL, USA.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Knight
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D016017:Odds Ratio; D016016:Proportional Hazards Models; D011655:Pulmonary Embolism / Q000139:chemically induced / Q000453:epidemiology*; D054556:Venous Thromboembolism / Q000139:chemically induced / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000139:chemically induced / Q000453:epidemiology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal
keywords: NSAIDs; epidemiology; meta-analysis; respiratory; systematic review