title: Regulation of SERCA pumps expression in diabetes.
abstract: Cytosolic calcium concentration ([Ca(2+)]c) is fundamental for regulation of many cellular processes such metabolism, proliferation, muscle contraction, cell signaling and insulin secretion. In resting conditions, the sarco/endoplasmic reticulum (ER/SR) Ca(2+) ATPase's (SERCA) transport Ca(2+) from the cytosol to the ER or SR lumen, maintaining the resting [Ca(2+)]c about 25-100nM. A reduced activity and expression of SERCA2 protein have been described in heart failure and diabetic cardiomyopathy, resulting in an altered Ca(2+) handling and cardiac contractility. In the diabetic pancreas, there has been reported reduction in SERCA2b and SERCA3 expression in β-cells, resulting in diminished insulin secretion. Evidence obtained from different diabetes models has suggested a role for advanced glycation end products formation, oxidative stress and increased O-GlcNAcylation in the lowered SERCA2 expression observed in diabetic cardiomyopathy. However, the role of SERCA2 down-regulation in the pathophysiology of diabetes mellitus and diabetic cardiomyopathy is not yet well described. In this review, we make a comprehensive analysis of the current knowledge of the role of the SERCA pumps in the pathophysiology of insulin-dependent diabetes mellitus type 1 (TIDM) and type 2 (T2DM) in the heart and β-cells in the pancreas.
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico. Electronic address: zarain@unam.mx.
authors.forename: Angel
authors.initials: A
authors.lastname: Zarain-Herzberg
authors.affiliation: Cátedra de Cardiología y Medicina Vascular, Escuela de Medicina, Tecnológico de Monterrey, Monterrey, Mexico; Centro de Investigación Básica y Transferencia, Hospital Zambrano Hellion, Tecnológico de Monterrey, San Pedro Garza-García, Mexico.
authors.forename: Gerardo
authors.initials: G
authors.lastname: García-Rivas
authors.affiliation: Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, México D.F., Mexico.
authors.forename: Rafael
authors.initials: R
authors.lastname: Estrada-Avilés
mesh_terms: D002118:Calcium / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics* / Q000473:pathology; D058065:Diabetic Cardiomyopathies / Q000235:genetics* / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism* / Q000473:pathology; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism
chemical_list: D007328:Insulin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; C506946:ATP2A2 protein, human; D002118:Calcium
keywords: Diabetic cardiomyopathy; Heart; Pancreas; Sarco/endoplasmic reticulum Ca(2+)-ATPase