title: Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.
abstract: Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.
authors.affiliation: Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California , Los Angeles, California 90089, United States.
authors.forename: Chun-Jun
authors.initials: CJ
authors.lastname: Guo
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Sun
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Bruno
authors.forename: Clay C C
authors.initials: CC
authors.lastname: Wang
mesh_terms: D001230:Aspergillus / Q000737:chemistry* / Q000235:genetics; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D053898:Biosynthetic Pathways / Q000235:genetics; D015394:Molecular Structure; D005810:Multigene Family; D011809:Quinones / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry / Q000378:metabolism
chemical_list: D001688:Biological Products; D011809:Quinones; D012459:Salicylates; C005236:6-methylsalicylic acid; C009400:terreic acid