title: The potential protective role of Physalis peruviana L. fruit in cadmium-induced hepatotoxicity and nephrotoxicity.
abstract: This study aimed to investigate the potential protective role of Physalis peruviana L. (family Solanaceae) against cadmium-induced hepatorenal toxicity in Wistar rats. Herein, cadmium chloride (CdCl2) (6.5 mg/kg bwt/day) was intraperitoneally injected for 5 days, and methanolic extract of physalis (MEPh) was pre-administered to a group of Cd-treated rats by an oral administration at a daily dose of 200 mg/kg bwt for 5 days. The findings revealed that CdCl2 injection induced significant decreases in kidney weight and kidney index. Cadmium intoxication increased the activities of liver enzymes and the bilirubin level, in addition to the levels of uric acid, urea and creatinine were increased in the serum. The pre-administration of MEPh alleviated hepatorenal toxicity in Cd-treated rats. Physalis was noted to play a good hepatorenal protective role, reducing lipid peroxidation, nitric oxide, and enhancing enzymatic activities and non-enzymatic antioxidant molecule, glutathione, in hepatic and renal tissues of Cd-treated rats. Moreover, physalis treatment was able to reverse the histopathological changes in liver and kidney tissues and also increased the expression of Bcl-2 protein in liver and kidney of rats. Overall, the results showed that MEPh can induce antioxidant and anti-apoptotic effects and also exerts beneficial effects for the treatment of Cd-induced hepatorenal toxicity.
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Dkhil
authors.affiliation: Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saleh
authors.initials: S
authors.lastname: Al-Quraishy
authors.affiliation: Department of Molecular Drug Evaluation, National Organization for Drug Control & Research (NODCAR), Giza, Egypt.
authors.forename: Marwa M S
authors.initials: MM
authors.lastname: Diab
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Biotechnology, Modern Sciences and Arts (MSA), Giza, Egypt.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Othman
authors.affiliation: Department of Biological Science, Faculty of Dentistry, Modern Sciences and Arts University (MSA), Giza, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Aref
authors.affiliation: Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt; Department of Biochemistry and Molecular Biology, Asturias Institute of Biotechnology, University of Oviedo, Oviedo, Spain. Electronic address: abdelahmed.uo@uniovi.es.
authors.forename: Ahmed E
authors.initials: AE
authors.lastname: Abdel Moneim
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D019256:Cadmium Chloride / Q000037:antagonists & inhibitors / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000517:prevention & control*; D005638:Fruit; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D032321:Physalis; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D019256:Cadmium Chloride
keywords: Cadmium; Kidney; Liver; Oxidative stress; Physalis peruviana L; Rats