title: Factors and mechanisms involved in the coupling from bone resorption to formation: how osteoclasts talk to osteoblasts.
abstract: Bone remodeling is the fundamental means by which the quality as well as quantity of the skeleton is maintained throughout adult life. When bone remodeling goes awry, a metabolic bone disease such as osteoporosis ensues. Among multiple phases of the complex remodeling process, we focus in this review on factors and mechanisms that are involved in the coupling of bone formation to preceding resorption.
authors.affiliation: Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Kyoji
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Japan.
authors.forename: Sunao
authors.initials: S
authors.lastname: Takeshita
keywords: Bone remodeling; Bone resorption; Osteoblasts; Osteoclasts