title: [Postvaccinal fatal Streptococcus zooepidemicus necrotizing fasciitis in a young dog: a case report].
abstract: A 2.5-years-old female mongrel dog was routinely subcutaneously vaccinated. A few hours later mental dullness was noticed by the owner progressing into stupor the next day and resulting in a comatose state and death within 48 hours after vaccination. At post mortem examination, which was extended with histology and bacteriology, a necrotizing fasciitis and bacteremia caused by Streptococcus equi subsp. zooepidemicus were established. In the isolated Streptococcus strain four different superantigens were demonstrated that appeared to be able to produce exotoxins in vitro. Therefore, it is concluded that the minor skin trauma caused by vaccination enabled this strain to gain access to the subcutaneous tissue and to induce a necrotizing fasciitis. This process was complicated with a bacterial septicemia leading to death of the dog within 48 hours.
authors.forename: S W M
authors.initials: SW
authors.lastname: Greijdanus-Van Der Putten
authors.forename: J H
authors.initials: JH
authors.lastname: Vos
authors.forename: J R V
authors.initials: JR
authors.lastname: Duvekot
authors.forename: R
authors.initials: R
authors.lastname: Paillot
authors.forename: R
authors.initials: R
authors.lastname: McLean
authors.forename: H J
authors.initials: HJ
authors.lastname: Brokers
authors.forename: A E
authors.initials: AE
authors.lastname: Heuvelink
authors.forename: N M
authors.initials: NM
authors.lastname: Meertens
authors.forename: A S
authors.initials: AS
authors.lastname: Waller
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D017809:Fatal Outcome; D005260:Female; D013290:Streptococcal Infections / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D018502:Streptococcus equi / Q000302:isolation & purification; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary