title: Antithrombotic activity of a new benzimidazole derivative in the thrombosis model in mice.
abstract: Antithrombotic activity of a new benzimidazole derivative RU-891, characterized by antiaggregant activity, vs. reference drug acetylsalicylic acid was studied on the epinephrinecollagen thrombosis model in mice. Antithrombotic activity of RU-891 3-fold surpassed that of the reference drug. Histological studies showed that RU-891 significantly reduced the relative and mean areas of thrombi in sections of mouse lungs in comparison with the control.
authors.affiliation: Department for Pathological Anatomy, Volgograd State Medical University, Volgograd, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnov
authors.forename: A F
authors.initials: AF
authors.lastname: Kucheryavenko
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: C583978:9-(2-(3,4-dihydroxydiphenyl)-2-oxoethyl)-2,3-dihydroimidazo(1,2-a)benzimidazole; D001562:Benzimidazoles