title: Recent advances in natural product discovery.
abstract: Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently genomics- and bioinformatics-guided bottom-up approaches have provided powerful alternative strategies. Here we review recent advances in natural product discovery from both angles, including diverse sampling and innovative culturing and screening approaches, as well as genomics-driven discovery and genetic manipulation techniques for both native and heterologous expression.
authors.affiliation: Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.
authors.forename: Yunzi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States.
authors.forename: Ryan E
authors.initials: RE
authors.lastname: Cobb
authors.affiliation: Department of Chemical and Biomolecular Engineering and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States; Departments of Chemistry, Biochemistry, and Bioengineering, and Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, IL 61801, United States. Electronic address: zhao5@illinois.edu.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhao
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods*; D004345:Drug Industry; D023281:Genomics / Q000379:methods; D007218:Industrial Microbiology; D055432:Metabolomics
chemical_list: D001688:Biological Products