title: Cancer-promoting and Inhibiting Effects of Dietary Compounds: Role of the Aryl Hydrocarbon Receptor (AhR).
abstract: Polyaromatic hydrocarbons, heterocyclic aromatic amines and dioxin-like compounds are environmental carcinogens shown to initiate cancer in a number of tissue types including prostate and breast. These environmental carcinogens elicit their effects through interacting with the aryl hydrocarbon receptor (AhR), a ligand activated transcription factor. Naturally occurring compounds found in fruits and vegetables shown to have anti-carcinogenic effects also interact with the AhR. This review explores dietary and environmental exposure to chemical carcinogens and beneficial natural compounds whose effects are elicited by the AhR.
authors.affiliation: Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA USA.
authors.forename: Joann B
authors.initials: JB
authors.lastname: Powell
authors.affiliation: Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA USA.
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghotbaddini
keywords: Aryl hydrocarbon receptor; Curcumin; Dioxin-like compound; Flavonoid; Heterocyclic aromatic amine; Polyaromatic hydrocarbon; Stilbene