title: Practical implementation of faecal transplantation.
abstract: Clostridium difficile infection is a leading cause of antibiotic-related and healthcare-related diarrhoea. In the past decade, faecal microbiota transplantation or transfer has attracted increasing interest as an effective treatment strategy for severe recurrent C. difficile infection, with a global success rate of >80%. However, experience with this procedure is limited by a lack of randomized trials supporting its efficacy and the lack of standardization of the procedure. This review will address the practical aspects of the protocol.
authors.affiliation: Laboratoire de Coprologie Fonctionnelle, APHP, GH Pitié-Salpêtrière Charles Foix, Université Paris Descartes, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Kapel
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: O
authors.initials: O
authors.lastname: Corcos
authors.forename: C
authors.initials: C
authors.lastname: Mayeur
authors.forename: L
authors.initials: L
authors.lastname: Barbot-Trystram
authors.forename: Y
authors.initials: Y
authors.lastname: Bouhnik
authors.forename: F
authors.initials: F
authors.lastname: Joly
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003015:Clostridium Infections / Q000382:microbiology / Q000628:therapy*; D003428:Cross Infection / Q000382:microbiology / Q000628:therapy*; D003967:Diarrhea / Q000382:microbiology / Q000628:therapy*; D005243:Feces; D006801:Humans; D016032:Randomized Controlled Trials as Topic
keywords: Clostridium difficile; donor faeces infusion; faecal transplantation; microbiota; recurrent infection