title: [Glycine receptors in nervous tissue and their functional role].
abstract: The literature data on glycine metabolism in neural tissue, mitochondrial Gly-cleaving system, Gly-catching system in neural and glial cells are summarized. The peculiarities of localization and distribution of specific glycine receptors and binding-sites in nervous tissue of mammals are described. Four types of glycine-binding receptors are described: own specific glycine receptor (Gly-R), ionotropic receptor, which binds N-methyl-D-aspartate selectively (NMDA-R), and ionotropic receptors of g-aminobutyrate (GABA A -R, GABA С -R). The features of glycine effects in neuroglial cultures are discussed.
authors.forename: V N
authors.initials: VN
authors.lastname: Nikandrov
authors.forename: T V
authors.initials: TV
authors.lastname: Balashevich
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D018698:Glutamic Acid / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D018684:Glycine Agents / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D016202:N-Methylaspartate / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018079:Receptors, GABA / Q000235:genetics / Q000378:metabolism; D018009:Receptors, Glycine / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018684:Glycine Agents; D018079:Receptors, GABA; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D005998:Glycine
keywords: glycine; metabolism; neural tissue cells; neuroprotective action; receptors; regulatory effects