title: Lead intoxication under environmental hypoxia impairs oral health.
abstract: We have reported that chronic lead intoxication under hypoxic environment induces alveolar bone loss that can lead to periodontal damage with the subsequent loss of teeth. The aim of the present study was to assess the modification of oral inflammatory parameters involved in the pathogenesis of periodontitis in the same experimental model. In gingival tissue, hypoxia increased inducible nitric oxid synthase (iNOS) activity (p < .01) and meanwhile lead decreased prostaglandin E2 (PGE2) content (p < .05). In submandibular gland (SMG), iNOS activity was enhanced by lead and PGE2 content was increased by both lead and hypoxia (p < .01) and even more by combined treatments (p < .001). In the SMG, hypoxia stimulated angiogenesis (p < .01) with blood extravasation. Adrenal glands were 22% bigger in those animals exposed to lead under hypoxic conditions. Results suggest a wide participation of inflammatory markers that mediate alveolar bone loss induced by these environmental conditions. The lack of information regarding oral health in lead-contaminated populations that coexist with hypoxia induced us to evaluate the alteration of inflammatory parameters in rat oral tissues to elucidate the link between periodontal damage and these environmental conditions.
authors.affiliation: a Department of Physiology, School of Dentistry , University of Buenos Aires , Buenos Aires , Argentina.
authors.forename: Antonela R
authors.initials: AR
authors.lastname: Terrizzi
authors.forename: Javier
authors.initials: J
authors.lastname: Fernandez-Solari
authors.forename: Ching M
authors.initials: CM
authors.lastname: Lee
authors.forename: María Pilar
authors.initials: MP
authors.lastname: Martínez
authors.forename: María Ines
authors.initials: MI
authors.lastname: Conti
mesh_terms: D016301:Alveolar Bone Loss / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005881:Gingiva / Q000473:pathology; D000860:Hypoxia / Q000150:complications / Q000473:pathology*; D007854:Lead / Q000633:toxicity*; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D009909:Oral Health; D010518:Periodontitis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism
chemical_list: D015415:Biomarkers; D007854:Lead; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat; D015232:Dinoprostone