title: A review on antidiabetic activity of Citrullus colocynthis Schrad.
abstract: Current studies have elaborated diabetes mellitus as one of the most prevalent endocrine disorder throughout the world. Citrullus colocynthis (C. colocynthis) is one of the most common traditional plants used as remedy against diabetes mellitus. It is well recognized by its hypoglycemic effect, which is substantiated in current phytotherapy. Its undesired effects include the disturbance of gastrointestinal and urinary tracts. This review article encompasses various blood glucose lowering studies that have been carried out till date. Various parts of plants used in extract preparation were roots, fruits, seeds, rinds and leaves. The nature of these extracts was ethnolic, methanolic, or aqueous and their doses varied from 10 to 500 mg/kg body weight/day. All these published articles elaborate C. colocynthis as a potential antiglycemic medicinal plant.
authors.forename: Chenghe
authors.initials: C
authors.lastname: Shi
authors.forename: Sabiha
authors.initials: S
authors.lastname: Karim
authors.forename: Chunyong
authors.initials: C
authors.lastname: Wang
authors.forename: Mingjing
authors.initials: M
authors.lastname: Zhao
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D029773:Citrullus; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts