title: Podosome rosettes precede vascular sprouts in tumour angiogenesis.
abstract: Expansion of a vascular network requires breaking through the basement membrane, a highly crosslinked barrier that tightly adheres to mature vessels. Angiogenic endothelial cells are now shown to form podosome rosettes that are able to focally degrade the extracellular matrix, prior to vascular sprouting in tumour angiogenesis.
authors.affiliation: Department of Molecular, Cell and Developmental Biology; University of California, Los Angeles, California 90095, USA.
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Warren
authors.affiliation: 1] Department of Molecular, Cell and Developmental Biology; University of California, Los Angeles, California 90095, USA [2] Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Iruela-Arispe
mesh_terms: D001485:Basement Membrane / Q000378:metabolism; D021961:Cell Membrane Structures / Q000378:metabolism / Q000502:physiology*; D042783:Endothelial Cells / Q000378:metabolism / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D039121:Integrin alpha6beta1 / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D039121:Integrin alpha6beta1