title: Protection of Momordica charantia polysaccharide against intracerebral hemorrhage-induced brain injury through JNK3 signaling pathway.
abstract: It has been well documented that Momordica charantia polysaccharide (MCP) has multiple biological effects such as immune enhancement, anti-oxidation and anti-cancer. However, the potential protective effects of MCP on stroke damage and its relative mechanisms remain unclear. Our present study demonstrated that MCP could scavenge reactive oxygen species (ROS) in intra-cerebral hemorrhage damage, significantly attenuating the neuronal death induced by thrombin in primary hippocampal neurons. Furthermore, we found that MCP prevented the activation of the c-Jun N-terminal protein kinase (JNK3), c-Jun and caspase-3, which was caused by the intra-cerebral hemorrhage injury. Taken together, our study demonstrated that MCP had a neuroprotective effect in response to intra-cerebral hemorrhage and its mechanisms involved the inhibition of JNK3 signaling pathway.
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Zhen-Zhen
authors.initials: ZZ
authors.lastname: Duan
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Zhou
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Yi-Hang
authors.initials: YH
authors.lastname: Li
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Feng-Ying
authors.initials: FY
authors.lastname: Li
authors.affiliation: a Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College , Xuzhou , P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Su-Hua
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015153:Blotting, Western; D001930:Brain Injuries / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000150:complications*; D005609:Free Radicals / Q000378:metabolism; D015151:Immunoblotting; D007124:Immunoenzyme Techniques; D047468:Immunoprecipitation; D008297:Male; D048057:Mitogen-Activated Protein Kinase 10 / Q000378:metabolism*; D029777:Momordica charantia / Q000737:chemistry*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D005609:Free Radicals; D018696:Neuroprotective Agents; D011134:Polysaccharides; D048057:Mitogen-Activated Protein Kinase 10
keywords: Intracerebral hemorrhage; JNK3 signaling pathway; Momordica charantia polysaccharide; reactive oxygen species