title: Transcatheter mitral valve implantation with Tiara bioprosthesis.
abstract: Mitral valve surgery is the gold standard therapy for severe mitral regurgitation, but can be associated with significant morbidity and mortality. Percutaneous mitral leaflet repair has recently been established as a viable alternative to surgery, but many patients are ineligible and repair may not be optimal. Transcatheter mitral valve implantation may be an alternate therapeutic option, particularly for high-risk patients. We outline the initial preclinical and first-in-human experience with the Tiara transapical mitral valve implantation system, highlighting the ease of implantation, proven feasibility and excellent haemodynamic performance.
authors.affiliation: The Centre for Heart Valve Innovation, St Paul's Hospital, Vancouver, Canada.
authors.forename: Anson
authors.initials: A
authors.lastname: Cheung
authors.forename: Dion
authors.initials: D
authors.lastname: Stub
authors.forename: Robert
authors.initials: R
authors.lastname: Moss
authors.forename: Robert H
authors.initials: RH
authors.lastname: Boone
authors.forename: Jonathon
authors.initials: J
authors.lastname: Leipsic
authors.forename: Stefan
authors.initials: S
authors.lastname: Verheye
authors.forename: Shmuel
authors.initials: S
authors.lastname: Banai
authors.forename: John
authors.initials: J
authors.lastname: Webb
mesh_terms: D000368:Aged; D000818:Animals; D001705:Bioprosthesis; D002417:Cattle; D057510:Endovascular Procedures; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve; D008944:Mitral Valve Insufficiency / Q000601:surgery