title: [Bone-targeted treatment in prostate cancer].
abstract: Prostate cancer is one of the most common cancers in men. In case of metastatic disease, bone manifestation is presented in 85-90% of the patients. The new targeted treatments are the denosumab RANK-ligand monoclonal antibody and Ra-223-chloride radioisotope therapy. This paper summarizes the treatment possibilities of bone metastasis and presents the results of phase III trials of denosumab and Ra-223-chloride. The upcoming change in financial support underlines the actuality of this paper.
authors.affiliation: Kemoterápia C Belgyógyászati-Onkológiai és Klinikai Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary. gelajos@oncol.hu.
authors.forename: Lajos
authors.initials: L
authors.lastname: Géczi
authors.affiliation: Nukleáris Medicina Osztály, Országos Onkológiai Intézet, Budapest, Hungary.
authors.forename: István
authors.initials: I
authors.lastname: Sinkovics
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D017326:Clinical Trials, Phase III as Topic; D000069448:Denosumab; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D053245:RANK Ligand / Q000037:antagonists & inhibitors*; D011868:Radioisotopes / Q000494:pharmacology / Q000627:therapeutic use; D011883:Radium / Q000494:pharmacology / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D053245:RANK Ligand; D011868:Radioisotopes; D000069448:Denosumab; D000469:Alkaline Phosphatase; D017430:Prostate-Specific Antigen; C581106:radium Ra 223 dichloride; D011883:Radium