title: Epithelioid inflammatory myofibroblastic sarcoma responsive to surgery and an ALK inhibitor in a patient with panhypopituitarism.
abstract: We encountered a case of epithelioid inflammatory myofibroblastic sarcoma (EIMS) originating from an abdominal organ that rapidly regrew twice. The patient underwent two surgeries. Large tumors grew within three months after the second surgery. The patient subsequently received chemotherapy with an anaplastic lymphoma kinase (ALK) inhibitor. Although EIMS has a poor prognosis, the patient continues to be alive with disease 14 months after surgical treatment and the administration of the ALK inhibitor.
authors.affiliation: Department of Metabolism and Endocrinology, Osaka City General Hospital, Japan.
authors.forename: Kotomi
authors.initials: K
authors.lastname: Kurihara-Hosokawa
authors.forename: Isao
authors.initials: I
authors.lastname: Kawasaki
authors.forename: Anna
authors.initials: A
authors.lastname: Tamai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Yakushiji
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ueno
authors.forename: Mariko
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fukushima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hosoi
mesh_terms: D000077548:Anaplastic Lymphoma Kinase; D003113:Colonoscopy; D003131:Combined Modality Therapy; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D007018:Hypopituitarism / Q000150:complications* / Q000175:diagnosis; D007414:Intestinal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D007421:Intestine, Small; D007813:Laparotomy / Q000379:methods*; D008297:Male; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012509:Sarcoma / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D004791:Enzyme Inhibitors; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases