title: Cephalic versus digital plethysmographic variability index measurement: a comparative pilot study in cardiac surgery patients.
abstract: OBJECTIVE
  Noninvasive measurement of digital plethysmographic variability index (PVI(digital)) has been proposed to predict fluid responsiveness, with conflicting results. The authors tested the hypothesis that cephalic sites of PVI measurement (namely PVI(ear) and PVI(forehead)) could be more discriminant than PVI(digital) to predict fluid responsiveness after cardiac surgery.
  
  
  METHODS
  A prospective observational study.
  
  
  METHODS
  A cardiac surgical intensive care unit of a university hospital.
  
  
  METHODS
  Fifty adult patients.
  
  
  METHODS
  Investigation before and after fluid challenge.
  
  
  RESULTS
  Patients were prospectively included within the first 6-hour postoperative period and investigated before and after fluid challenge. A positive response to fluid challenge was defined as a 15% increase in cardiac index. PVI(digital), PVI(ear), PVI(forehead), and invasive arterial pulse-pressure variation (PPV) measurements were recorded simultaneously, and receiver operating characteristic (ROC) curves were built. Forty-one (82%) patients were responders and 9 (18%) patients were nonresponders to fluid challenge. ROCAUC were 0.74 (95% confidence interval [95% CI]: 0.60-0.86), 0.81 (95% CI: 0.68-0.91), 0.88 (95% CI: 0.75-0.95) and 0.87 (95% CI: 0.75-0.95) for PVI(digital), PVI(ear), PVI(forehead), and PPV, respectively. Significant differences were observed between PVI(forehead) and PVI(digital) (absolute difference in ROCAUC = 0.134 [95% CI: 0.003-0.265], p = 0.045) and between PPV and PVI(digital) (absolute difference in ROCAUC = 0.129 [95% CI: 0.011-0.247], p = 0.033). The percentage of patients within the inconclusive class of response was 46%, 70%, 44%, and 26% for PVI(digital), PVI(ear), PVI(forehead), and PPV, respectively.
  
  
  CONCLUSIONS
  PVI(forehead) was more discriminant than PVI(digital) and could be a valuable alternative to arterial PPV in predicting fluid responsiveness.
authors.affiliation: Departments of *Anesthesia and Critical Care Medicine; University of Caen, Caen, France. Electronic address: fischer-mo@chu-caen.fr.
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Fischer
authors.affiliation: Cardiology.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Pellissier
authors.affiliation: Cardiac Surgery, CHU de Caen, Caen, France.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Saplacan
authors.affiliation: Departments of *Anesthesia and Critical Care Medicine; University of Caen, Caen, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gérard
authors.affiliation: Departments of *Anesthesia and Critical Care Medicine; University of Caen, Caen, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Hanouz
authors.affiliation: Departments of *Anesthesia and Critical Care Medicine; University of Caen, Caen, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Fellahi
mesh_terms: D000368:Aged; D062186:Arterial Pressure / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D006348:Cardiac Surgical Procedures; D004423:Ear / Q000098:blood supply; D005385:Fingers / Q000098:blood supply; D005440:Fluid Therapy; D005546:Forehead / Q000098:blood supply; D006801:Humans; D016343:Monitoring, Intraoperative / Q000379:methods*; D010865:Pilot Projects; D010991:Plethysmography / Q000379:methods; D011446:Prospective Studies; D012372:ROC Curve; D012039:Regional Blood Flow / Q000502:physiology
keywords: fluid challenge; fluid responsiveness; plethysmographic variability index; plethysmography; pulse-pressure variation