title: Uterine tumors resembling ovarian sex cord tumors, a clinicopathologic study of six cases.
abstract: Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) cause difficulties, both with respect to diagnosis as well as to the nomenclature. They belong to the group of low-grade malignant neoplasms, and their clinical course likely depends on the percentage of the sex cord-like component. Morphologically, they can be divided into type I and type II with less or more than 50% of sex cord-like areas, respectively. Six patients with an age range of 24 to 63 years underwent the treatment for primary UTROSCT at the Cancer Center and Institute of Oncology in Warsaw, Poland, between 2000 and 2011. In addition to the surgery, 4 patients were treated with gestagens. Biopsies or excisions from the tumors were examined microscopically and immunohistochemically. Two cases were classified as type I, and 4 cases, as type II tumors. The tumor size ranged from 3 to 24 cm. The sex cord component varied from 25% to 70%. By immunohistochemical examination, the sex cord-like component was calretinin positive, whereas the stromal component was positive for CD10 and negative for h-caldesmon in all the cases studied. In addition, progesterone receptor positivity was found in all the cases, and 4 tumors were positive for smooth muscle actin, cytokeratin AE1/3, and inhibin. No recurrences were noted in any of the 6 patients over 3 to 14.5 years of follow-up period. A correct subclassification of sarcomas of UTROSCT type is of crucial importance because most patients with this rare neoplasm respond well to gestagen therapy and have a good prognosis, compared with other uterine stromal sarcomas.
authors.affiliation: Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland. Electronic address: elwirabz@onet.eu.
authors.forename: Elwira
authors.initials: E
authors.lastname: Bakula-Zalewska
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Warsaw, 00-315 Warsaw, Poland. Electronic address: ad.bidzinska@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Danska-Bidzinska
authors.affiliation: Department of Molecular and Translational Oncology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland; Department of Immunology, Biochemistry and Nutrition, Medical University of Warsaw, 02-097 Warsaw, Poland. Electronic address: magdak@coi.waw.pl.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kowalewska
authors.affiliation: Department of Pathology, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, 02-781 Warsaw, Poland. Electronic address: agata_piascik@o2.pl.
authors.forename: Agata
authors.initials: A
authors.lastname: Piascik
authors.affiliation: Department of Pathology, Jan Kochanowski University, 25-517 Kielce, Poland. Electronic address: anna.nasierowska@cskmswia.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Nasierowska-Guttmejer
authors.affiliation: Department of Health, Jan Kochanowski University, 25-517 Kielce, Poland. Electronic address: bidzinski.m@gmail.com.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Bidzinski
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D011044:Poland; D011372:Progestins / Q000627:therapeutic use; D011379:Prognosis; D018312:Sex Cord-Gonadal Stromal Tumors / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D011372:Progestins
keywords: Endometrial stromal tumor; Gestagen therapy; Sex cord-like; UTROSCT; Uterine tumors resembling ovarian sex cord tumors