title: TRPC1, CaN and NFATC3 signaling pathway in the pathogenesis and progression of left ventricular hypertrophy in spontaneously hypertensive rats.
abstract: Spontaneously hypertensive rats (SHR) was used to study left ventricular hypertrophy (LVH) and its dynamic change after the interventions with Telmisartan and Amlodipine. The results showed that the expression of TRPC1, CaN and NFATC3 increased gradually with the pathogenesis and progression of LVH. Telmisartan reduced blood pressure and LVH, and down-regulated the expression of TRPC1, CaN and NFATC3 in left ventricle of SHR. Amlodipine reduced the blood pressure in SHR but had no impact on the hypertrophy and expression of above factors. Our data suggest that the pathogenesis and progression of LVH in SHR are related to upregulation of TRPC1, CaN and NFATC3 signaling pathway.
authors.affiliation: Union Clinical Medical College, Fujian Medical University , Fuzhou, Fujian , China .
authors.forename: Guangrong
authors.initials: G
authors.lastname: Zou
authors.forename: Huashan
authors.initials: H
authors.lastname: Hong
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Lin
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Shi
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.forename: Lianglong
authors.initials: L
authors.lastname: Chen
mesh_terms: D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D004195:Disease Models, Animal; D018450:Disease Progression; D006352:Heart Ventricles / Q000378:metabolism / Q000473:pathology; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D050778:NFATC Transcription Factors / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D015398:Signal Transduction / Q000187:drug effects*; D050052:TRPC Cation Channels / Q000378:metabolism*; D000077333:Telmisartan
chemical_list: D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001565:Benzoates; D050778:NFATC Transcription Factors; D050052:TRPC Cation Channels; C445503:transcription factor NF-AT c3; C096351:transient receptor potential cation channel, subfamily C, member 1; D017311:Amlodipine; D000077333:Telmisartan
keywords: Amlodipine; TRPC1; Telmisartan; left ventricular hypertrophy; spontaneously hypertensive rats