title: Classification and evolution of human rhinoviruses.
abstract: The historical classification of human rhinoviruses (RV) by serotyping has been replaced by a logical system of comparative sequencing. Given that strains must diverge within their capsid sequenced by a reasonable degree (>12-13 % pairwise base identities) before becoming immunologically distinct, the new nomenclature system makes allowances for the addition of new, future types, without compromising historical designations. Currently, three species, the RV-A, RV-B, and RV-C, are recognized. Of these, the RV-C, discovered in 2006, are the most unusual in terms of capsid structure, receptor use, and association with severe disease in children.
authors.affiliation: Institute for Molecular Virology, University of Wisconsin-Madison, 1525 Linden Drive, Madison, WI, 53706, USA, acpalmen@wisc.edu.
authors.forename: Ann C
authors.initials: AC
authors.lastname: Palmenberg
authors.forename: James E
authors.initials: JE
authors.lastname: Gern
mesh_terms: D002213:Capsid / Q000502:physiology; D036022:Capsid Proteins / Q000235:genetics; D003139:Common Cold / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D011995:Recombination, Genetic; D012229:Rhinovirus / Q000145:classification* / Q000502:physiology*
chemical_list: D036022:Capsid Proteins