title: Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiae.
abstract: Aging determinants are asymmetrically distributed during cell division in S. cerevisiae, which leads to production of an immaculate, age-free daughter cell. During this process, damaged components are sequestered and retained in the mother cell, and higher functioning organelles and rejuvenating factors are transported to and/or enriched in the bud. Here, we will describe the key quality control mechanisms in budding yeast that contribute to asymmetric cell division of aging determinants including mitochondria, endoplasmic reticulum (ER), vacuoles, extrachromosomal rDNA circles (ERCs), and protein aggregates.
authors.affiliation: Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Ryo
authors.initials: R
authors.lastname: Higuchi-Sanabria
authors.forename: Wolfgang M A
authors.initials: WM
authors.lastname: Pernice
authors.forename: Jason D
authors.initials: JD
authors.lastname: Vevea
authors.forename: Dana M
authors.initials: DM
authors.lastname: Alessi Wolken
authors.forename: Istvan R
authors.initials: IR
authors.lastname: Boldogh
authors.forename: Liza A
authors.initials: LA
authors.lastname: Pon
mesh_terms: D060049:Asymmetric Cell Division; D001692:Biological Transport; D015388:Organelles / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000502:physiology*
keywords: asymmetric cell division; lifespan control; mother-daughter age asymmetry