title: Preventive effects of zingerone on altered lipid peroxides and nonenzymatic antioxidants in the circulation of isoproterenol-induced myocardial infarcted rats.
abstract: The present study was designed to evaluate the preventive effects of zingerone on circulatory lipid peroxides and nonenzymatic antioxidants in isoproterenol-induced myocardial infarcted rats. Rats were pretreated with zingerone (6 mg/kg body weight) daily for a period of 14 days and were then induced myocardial infarction with isoproterenol (100 mg/kg body weight) on 15th and 16th day. Increased intensities of serum lactate dehydrogenase isoenzymes 1 and 2 bands enhanced plasma lipid peroxidation products and lowered nonenzymatic antioxidant system were noted in isoproterenol-induced rats. Pretreatment with zingerone daily for 14 days revealed significant preventive effects on the electrophoretic and biochemical parameters evaluated in isoproterenol-induced rats. Furthermore, the in vitro study confirmed the potent antioxidant activity of zingerone. The results of our study showed that zingerone protected the rat's heart against isoproterenol-induced myocardial infarction by its antioxidant effect.
authors.affiliation: Department of Biochemistry and Biotechnology, Annamalai University, Annamalai Nagar, 608 002, India.
authors.forename: K L
authors.initials: KL
authors.lastname: Hemalatha
authors.forename: P Stanely Mainzen
authors.initials: PS
authors.lastname: Prince
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000009:adverse effects* / Q000494:pharmacology; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007545:Isoproterenol / Q000009:adverse effects* / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; C013738:zingerone; D006139:Guaiacol; D007545:Isoproterenol
keywords: Antioxidants; Isoproterenol; Lipid peroxidation; Myocardial infarction; Zingerone