title: Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects.
abstract: BACKGROUND
  Published data on the association between AURKA polymorphisms and breast cancer (BC) risk are inconclusive. This meta-analysis was performed to derive a more precise estimation on the relationship between AURKA polymorphisms (rs2273535 and rs1047972) and BC risk.
  
  
  METHODS
  PubMed, Web of Knowledge and Embase were searched for relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to estimate the strength of associations. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for allele contrast genetic model, homozygous genetic model, heterozygote genetic model, dominant model, and recessive model, respectively.
  
  
  RESULTS
  A total of 13 studies (16,349 BC patients and 20,872 case-free controls) were involved in this meta-analysis. Meta-analysis showed that there was significant association between rs2273535 and BC risk in three genetic models in the overall population (A vs. T: OR = 1.08, 95% CI = 1.01-1.15, P = 0.02; AA vs. TT: OR = 1.36, 95% CI = 1.06-1.73, P < 0.00001; AA vs. TT + TA: OR = 1.15, 95% CI = 1.01-1.31, P = 0.04). In the subgroup analysis by ethnicity, the effects remained in Asians (allele contrast genetic model: OR = 1.12, 95% CI = 1.00-1.26, P = 0.04 and homozygote comparison: OR = 1.22, 95% CI = 1.06-1.41, P = 0.007). However, no genetic models reached statistical association in Cauasians. Rs1047972 polymorphism was associated with BC risk in the overall population based on homozygote comparison (AA vs. GG: OR = 0.81, 95% CI = 0.66-0.99, P = 0.04). When stratified by ethnicity, rs1047972 polymorphism had a decreased association with BC risk in Caucasians based on allele contrast genetic model, homozygote comparison, the dominant model and the recessive model. However, there was no association in any genetic model in Asians.
  
  
  CONCLUSIONS
  This meta-analysis suggests that AURKA rs2273535 polymorphism has an increased risk with BC, especially in Asians. However, rs1047972 polymorphism has a decreased BC risk in Caucasians. Further large scale multicenter epidemiological studies are warranted to confirm this finding.
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China ; Center for Translational Medicine, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, Xi'an, 710049 China.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Dai
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Kang
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Xi-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Center for Translational Medicine, Frontier Institute of Science and Technology (FIST), Xi'an Jiaotong University, Xi'an, 710049 China.
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Shao
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Shuai
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Ren
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Min
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004 China.
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Liu
keywords: AURKA; Breast cancer; Meta-analysis; Polymorphism; Susceptibility