title: Maternal anemia during pregnancy and subsequent risk for cardiovascular disease.
abstract: OBJECTIVE
  To investigate the association between anemia during pregnancy and subsequent future maternal cardiovascular morbidity and mortality.
  
  
  METHODS
  A retrospective cohort study was conducted, comparing women with and without anemia during pregnancy. Deliveries occurred during 1988-1998 and had followed for more than a decade. Incidence of long-term cardiovascular morbidity was compared between the two groups.
  
  
  RESULTS
  During the study period, 47 657 deliveries met the inclusion criteria; of these 12 362 (25.9%) occurred in women with anemia at least once during their pregnancies. Anemia of pregnancy was noted as a risk factor for long-term complex cardiovascular events (OR = 1.6, 95% CI 1-2.8, p = 0.04). Using a Cox multivariable regression model, controlling for ethnicity and maternal age, anemia was found to be an independent risk factor for long-term maternal cardiovascular hospitalization (OR for total hospitalizations = 1.2, 95% CI 1.1-1.4, p < 0.001).
  
  
  CONCLUSIONS
  Anemia of pregnancy is an independent risk factor for long-term cardiovascular morbidity in a follow-up period of more than a decade.
authors.affiliation: a Department of Obstetrics and Gynecology, Faculty of Health Sciences , Soroka University Medical Center, Ben-Gurion University of the Negev , Beer-Sheva , Israel and.
authors.forename: Carmit Erez
authors.initials: CE
authors.lastname: Azulay
authors.forename: Gali
authors.initials: G
authors.lastname: Pariente
authors.forename: Ilana
authors.initials: I
authors.lastname: Shoham-Vardi
authors.forename: Roy
authors.initials: R
authors.lastname: Kessous
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000328:Adult; D000740:Anemia / Q000150:complications* / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009035:Mothers / Q000706:statistics & numerical data; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: Anemia; PTD; SGA; cardiovascular risk; pregnancy