title: HTRA3 is reduced in ovarian cancers regardless of stage.
abstract: Ovarian cancer is the leading cause of death in gynaecological cancers. The high temperature requirement factor A3 (HtrA3) is involved in the pathogenesis of ovarian cancer. In this study we investigated whetherHtrA3 protein levels were altered in subtypes of ovarian cancer and whether HtrA3 down-regulation was associated with peritoneal metastasis. Ovarian cancer tissues from 89 patients were analyzed by immunohistochemistry. The levels of HtrA3 protein were lower in all subtypes of ovarian cancer and the lowest levels of HtrA3 were in epithelial ovarian cancer. The down-regulation of HtrA3 levels was not correlated with peritoneal metastasis of epithelial ovarian cancer.
authors.affiliation: Wuxi Maternity and Children Health Hospital, Nanjing Medical University, China,1.
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: J X
authors.initials: JX
authors.lastname: Ding
authors.forename: G Y
authors.initials: GY
authors.lastname: Nie
authors.forename: J
authors.initials: J
authors.lastname: Wei
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X Y
authors.initials: XY
authors.lastname: Yin
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D012697:Serine Endopeptidases / Q000378:metabolism*; D055815:Young Adult
chemical_list: C474013:HTRA3 protein, human; D012697:Serine Endopeptidases
keywords: Epithelial ovarian cancer; HtrA3; Ovarian cancer; Peritoneal metastasis