title: Association between serum uric acid and mortality in a Chinese population of hypertensive patients.
abstract: OBJECTIVE
  To investigate the association between serum uric acid and mortality in a Chinese population of hypertensive patients.
  
  
  RESULTS
  A total of 2757 Chinese hypertensive patients from department of cardiology of several hospitals in Shanghai in China were followed up for about six years in this prospective study. Mortality was recorded and related factors were evaluated. Hyperuricemia was diagnosed by serum uric acid levels of >420 µmol/L in males or >357 µmol/L in females. A total of 2585 hypertensive patients with complete data were included in the final statistical analysis. Totally 709 deaths (27.4%) occurred during the six-year follow-up, of which 475 deaths were attributable to cardiovascular disease (CVD). All-cause and CVD mortality of hypertensive patients with hyperuricemia was significantly higher than that of patients without hyperuricemia. The Cox regression analysis indicated that hazards ratios (HRs) of hyperuricemia for all-cause and CVD mortality were 1.206 (95% CI: 1.002-1.453) and 1.085 (95% CI: 1.002-1.271) respectively. All-cause and CVD mortality of hypertensive patients was significantly increased (both p < 0.05) when uric acid levels increased. HRs of uric acid levels >536 µmol/L to all-cause and CVD mortality of hypertensive patients were 2.115 (95% CI: 1.596-2.801) and 1.861 (95% CI: 1.296-2.673), respectively, compared with those of uric acid levels ≤357 µmol/L.
  
  
  CONCLUSIONS
  The data from this cohort study indicate that hyperuricemia can predict increased all-cause and CVD mortality in hypertensive patients.
authors.affiliation: Department of Cardiology, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Chinese Ministry of Education and Chinese Ministry of Health , Jinan , China .
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Dongdong
authors.initials: D
authors.lastname: Zhao
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Guo
authors.forename: Jing-Quan
authors.initials: JQ
authors.lastname: Zhong
mesh_terms: D000368:Aged; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000401:mortality; D033461:Hyperuricemia / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Cardiovascular disease; hypertension; hyperuricemia; mortality; risk factors