title: Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia.
abstract: BACKGROUND
  Androgenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. However, expert opinions about the usefulness of DHT in the diagnosis of this type of alopecia are divided.
  
  
  OBJECTIVE
  To evaluate the usefulness of DHT level in patients with androgenetic alopecia compared with the control group.
  
  
  METHODS
  The study comprised 49 subjects: 19 women and 9 men with androgenetic alopecia. The control group consisted of 17 healthy women and 4 men without hair loss.
  
  
  RESULTS
  Increased serum concentrations of DHT were observed in patients with androgenetic alopecia (17 women, 5 men), but also in the control group. The differences in mean values of DHT were not significant according to the types of alopecia and the control group. Increased serum concentrations of DHT were not correlated with the advance of alopecia.
  
  
  CONCLUSIONS
  Dihydrotestosterone is the most influential androgen and seems to play a very important role in the pathogenesis of androgenetic alopecia. Based on the results of our study and others, the most important factors would appear to be the genetically-determined sensitivity of the follicles to DHT and their different reactions to androgen concentration.
authors.affiliation: Department of General Dermatology, Esthetic and Dermatosurgery, Medical University of Lodz, Poland. Head of Department: Prof. Grażyna Broniarczyk-Dyła MD, PhD.
authors.forename: Izabela
authors.initials: I
authors.lastname: Urysiak-Czubatka
authors.affiliation: Department of General Dermatology, Esthetic and Dermatosurgery, Medical University of Lodz, Poland. Head of Department: Prof. Grażyna Broniarczyk-Dyła MD, PhD.
authors.forename: Małgorzata L
authors.initials: ML
authors.lastname: Kmieć
authors.affiliation: Department of General Dermatology, Esthetic and Dermatosurgery, Medical University of Lodz, Poland. Head of Department: Prof. Grażyna Broniarczyk-Dyła MD, PhD.
authors.forename: Grażyna
authors.initials: G
authors.lastname: Broniarczyk-Dyła
keywords: androgenetic alopecia; diagnostic; dihydrotestosterone