title: Prevalence of chromosomally integrated human herpesvirus 6 in patients with human herpesvirus 6-central nervous system dysfunction.
abstract: We identified 37 hematopoietic cell transplantation recipients with human herpesvirus 6 (HHV-6) central nervous system dysfunction and tested donor-recipient pairs for chromosomally integrated HHV-6 (ciHHV-6). One patient had ciHHV-6A with possible HHV-6A reactivation and encephalitis. There was no ciHHV-6 enrichment in this group, but larger studies are needed to determine if patients with ciHHV-6 are at increased risk for HHV-6-associated diseases or other complications.
authors.affiliation: Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: joshuaah@uw.edu.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Hill
authors.affiliation: Division of Laboratory Medicine, University of Washington, Seattle, Washington.
authors.forename: Ruth Hall
authors.initials: RH
authors.lastname: Sedlak
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Seattle Children's Research Institute, Seattle, Washington.
authors.forename: Danielle M
authors.initials: DM
authors.lastname: Zerr
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Meei-Li
authors.initials: ML
authors.lastname: Huang
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Yeung
authors.affiliation: Department of Pathology, University of Washington, Seattle, Washington; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: David
authors.initials: D
authors.lastname: Myerson
authors.affiliation: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington; Division of Laboratory Medicine, University of Washington, Seattle, Washington.
authors.forename: Keith R
authors.initials: KR
authors.lastname: Jerome
authors.affiliation: Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Boeckh
mesh_terms: D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002877:Chromosomes, Human / Q000737:chemistry / Q000821:virology*; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology / Q000821:virology*; D018380:Hematopoietic Stem Cell Transplantation; D015654:Herpesvirus 6, Human / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D058889:Molecular Typing; D010802:Phylogeny; D019349:Roseolovirus Infections / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology / Q000821:virology*; D014184:Transplantation, Homologous; D014775:Virus Activation; D016662:Virus Integration
chemical_list: D004279:DNA, Viral
keywords: Central nervous system (CNS); Herpesvirus (hhv-6); Integration; Transplant