title: Extracellular vesicles as enhancers of virus vector-mediated gene delivery.
abstract: Extracellular vesicles (EVs) being released from two adjacent adeno-associated virus serotype 1 (AAV1)-producing 293T cells are shown by electron microscopy. We have shown that AAV vectors can associate with EVs and enter the media. Furthermore, we have recently reported that EV-associated AAV has robust gene delivery and antibody evasion properties in vivo.
authors.affiliation: 1 Department of Neurology, The Massachusetts General Hospital , and Neuroscience Program, Harvard Medical School, Boston, MA 02129.
authors.forename: Zachary
authors.initials: Z
authors.lastname: Fitzpatrick
authors.forename: Bence
authors.initials: B
authors.lastname: György
authors.forename: Johan
authors.initials: J
authors.lastname: Skog
authors.forename: Casey A
authors.initials: CA
authors.lastname: Maguire
mesh_terms: D000229:Dependovirus / Q000648:ultrastructure*; D018014:Gene Transfer Techniques; D005822:Genetic Vectors / Q000235:genetics*; D008854:Microscopy, Electron / Q000379:methods*; D022161:Transport Vesicles / Q000235:genetics* / Q000821:virology*