title: Control effects of stimulus paradigms on characteristic firings of parkinsonism.
abstract: Experimental studies have shown that neuron population located in the basal ganglia of parkinsonian primates can exhibit characteristic firings with certain firing rates differing from normal brain activities. Motivated by recent experimental findings, we investigate the effects of various stimulation paradigms on the firing rates of parkinsonism based on the proposed dynamical models. Our results show that the closed-loop deep brain stimulation is superior in ameliorating the firing behaviors of the parkinsonism, and other control strategies have similar effects according to the observation of electrophysiological experiments. In addition, in conformity to physiological experiments, we found that there exists optimal delay of input in the closed-loop GPtrain|M1 paradigm, where more normal behaviors can be obtained. More interestingly, we observed that W-shaped curves of the firing rates always appear as stimulus delay varies. We furthermore verify the robustness of the obtained results by studying three pallidal discharge rates of the parkinsonism based on the conductance-based model, as well as the integrate-and-fire-or-burst model. Finally, we show that short-term plasticity can improve the firing rates and optimize the control effects on parkinsonism. Our conclusions may give more theoretical insight into Parkinson's disease studies.
authors.affiliation: Department of Dynamics and Control, Beihang University, Beijing 100191, People's Republic of China.
authors.forename: Honghui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Dynamics and Control, Beihang University, Beijing 100191, People's Republic of China.
authors.forename: Qingyun
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Electronic Engineering, City University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Guanrong
authors.initials: G
authors.lastname: Chen
mesh_terms: D001479:Basal Ganglia / Q000503:physiopathology*; D046690:Deep Brain Stimulation; D006801:Humans; D008959:Models, Neurological; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy; D009435:Synaptic Transmission