title: Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved.
abstract: In this retrospective study, the efficiency of carrying out rescue intrauterine insemination (IUI) in low-responder patients undergoing IVF when no oocytes were retrieved after follicular aspiration and when HCG timing was adequate was analysed. A historical control group was used. Over 13 years, women undergoing IVF with failure to obtain oocytes at follicular aspiration underwent rescue IUI if the following criteria were met: adequate HCG timing; one normal tube; motile sperm count after preparation over 3 million/ml; and ultrasound visualization of one to six follicles over 13 mm. The rescue IUI was carried out 1 h after follicular aspiration. Results were compared with those of a standard IUI population (5394 cycles) in the same period. Confidence intervals were calculated using Poisson 97.5% confidence upper tail limits when no event was observed in the study sample. No pregnancies were achieved among the 54 cases who underwent rescue IUI (confidence interval: 0 to 6.8%). This pregnancy rate was lower than that observed in the general IUI population (17.5%) (relative risk, 19.2). After adjusting for age and endometriosis, the relative risk was 11.7. The rescue IUI is an inefficient procedure. Its efficacy is unlikely to exceed 7% pregnancy rate per IUI.
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Matorras
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Victoria
authors.initials: V
authors.lastname: Aparicio
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Corcostegui
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Prieto
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Rosario
authors.initials: R
authors.lastname: Mendoza
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Olga
authors.initials: O
authors.lastname: Ramón
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain.
authors.forename: Oihane
authors.initials: O
authors.lastname: Gomez-Picado
authors.affiliation: Human Reproduction Unit, Cruces University Hospital, University of the Basque Country, Plaza de Cruces s/n Baracaldo (Vizcaya), 48903 Vizcaya, Spain. Electronic address: antonia.expositonavarro@osakidetza.net.
authors.forename: Antonia
authors.initials: A
authors.lastname: Exposito
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004715:Endometriosis / Q000150:complications; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D009865:Oocytes / Q000166:cytology / Q000187:drug effects*; D010062:Ovulation Induction; D016012:Poisson Distribution; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013081:Sperm Motility; D016896:Treatment Outcome
chemical_list: D006063:Chorionic Gonadotropin
keywords: IUI; IVF; empty follicle syndrome; low responders; oocyte; rescue