title: [Current issues on gastroesophageal reflux disease].
abstract: Gastroesophageal reflux disease (GERD) is one of the most common problems in gastrointestinal disorders. With the increase in our understanding on the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extraesophageal manifestations. This has led to significant confusion regarding the optimal approach to these patients. This article aims to discuss current issues on GERD.
authors.affiliation: Department of Internal Medicine, Kosin University College of Medicine, Seoul, Korea.
authors.forename: Jie-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Beom Jin
authors.initials: BJ
authors.lastname: Kim
authors.affiliation: Chonbuk National University Medical School, Jeonju, Korea.
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Kosin University College of Medicine, Busan, Korea.
authors.forename: Sung Eun
authors.initials: SE
authors.lastname: Kim
authors.affiliation: Hallym University College of Medicine, Chuncheon, Korea.
authors.forename: Yeon Soo
authors.initials: YS
authors.lastname: Kim
authors.affiliation: Wonkwang University College of Medicine, Iksan, Korea.
authors.forename: Hye Young
authors.initials: HY
authors.lastname: Sung
authors.affiliation: Inje University College of Medicine, Seoul, Korea.
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Oh
authors.affiliation: University of Ulsan College of Medicine, Ulsan, Korea.
authors.forename: In Du
authors.initials: ID
authors.lastname: Jeong
authors.affiliation: Kosin University College of Medicine, Busan, Korea.
authors.forename: Moo In
authors.initials: MI
authors.lastname: Park
mesh_terms: D000464:Alginates / Q000627:therapeutic use; D016099:Endoscopy, Gastrointestinal; D050782:Esophageal pH Monitoring; D058786:GABA-B Receptor Agonists / Q000627:therapeutic use; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008787:Metoclopramide / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D000464:Alginates; D058786:GABA-B Receptor Agonists; D054328:Proton Pump Inhibitors; D008787:Metoclopramide
keywords: Diagnosis; Gastroesophageal reflux; Pathophysiology; Therapeutics