title: Epidemiological studies of oats consumption and risk of cancer and overall mortality.
abstract: A review of epidemiological studies on the intake of oats and oat-based products and its effect on the risk of chronic disease and deaths was performed. Seven studies were identified of cancer risk (two each on prostate and colorectal cancer, and one each on pancreatic, breast and endometrial cancer), and one study on overall mortality. With the exception of a case-control study of pancreatic cancer, all studies were of cohort design: five studies were based on a single cohort from Denmark. The results of most cohort studies suggest a weak protective effect of a high intake of oats on cancer risk (relative risks in the order of 0·9). Potential limitations of the studies are dietary exposure misclassification, low statistical power because of limited exposure contrast and residual confounding. Despite the evidence from experimental and mechanistic studies of a protective effect of oats intake on CVD and diabetes, no epidemiological studies have been conducted on these conditions.
authors.affiliation: The Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai,New York,NY10029,USA.
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.affiliation: Division of Applied Medicine, University of Aberdeen, Polwarth Building, Foresterhill, AberdeenAB25 2ZD,Scotland,UK.
authors.forename: Frank
authors.initials: F
authors.lastname: Thies
authors.affiliation: Department of Nutritional Sciences,Pennsylvania State University,University Park,PA16802,USA.
authors.forename: Penny
authors.initials: P
authors.lastname: Kris-Etherton
mesh_terms: D018554:Avena; D001943:Breast Neoplasms / Q000517:prevention & control; D015179:Colorectal Neoplasms / Q000517:prevention & control; D004032:Diet; D002523:Edible Grain; D016889:Endometrial Neoplasms / Q000517:prevention & control; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000517:prevention & control*; D011471:Prostatic Neoplasms / Q000517:prevention & control; D012306:Risk