title: The effect of renin-angiotensin system inhibitors on intact parathyroid hormone levels in peritoneal dialysis patients.
abstract: OBJECTIVE
  The objective of this article is to investigate the effect of renin-angiotensin system inhibitors (RASIs) on intact parathyroid hormone (iPTH) levels in continuous ambulatory peritoneal dialysis (CAPD) patients.
  
  
  METHODS
  All patients were divided into RASI-treated and non-treated groups. The relationships between the iPTH levels in CAPD patients and the clinical parameters and medication use were analyzed via linear regression.
  
  
  RESULTS
  A total of 149 CAPD patients were included in this study. The average iPTH level of the entire group was 189.4 pg/ml (range, 102.8-373.4 pg/ml). There were 79 (53.0%) and 70 (47.0%) cases in the RASI-treated and non-treated groups, respectively, with average iPTH levels of 139.0 pg/ml (range, 91.6-258.4 pg/ml) and 253.0 pg/ml (range, 134.3-467.2 pg/ml), respectively; this difference was statistically significant (p = 0.001). Multilinear regression analysis showed that age, dialysis vintage, serum phosphatemia, ALP, Hb and RASI use were independent factors that were associated with iPTH level.
  
  
  CONCLUSIONS
  RASI use may be associated with a lower iPTH level in CAPD patients, although the underlying mechanism requires further study.
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Luyan
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Feng
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Han
authors.initials: H
authors.lastname: Ouyang
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China.
authors.forename: Yongbing
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Soochow University, China shenhy513@sina.com.
authors.forename: Huaying
authors.initials: H
authors.lastname: Shen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood*; D010530:Peritoneal Dialysis; D012084:Renin-Angiotensin System; D055815:Young Adult
chemical_list: D010281:Parathyroid Hormone
keywords: Peritoneal dialysis; diabetes mellitus; hyperphosphatemia; parathyroid hormone; renin-angiotensin system inhibitors