title: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
abstract: GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology.
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Maya
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authors.lastname: Ghoussaini
authors.affiliation: 1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Stacey L
authors.initials: SL
authors.lastname: Edwards
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Kyriaki
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authors.lastname: Michailidou
authors.affiliation: Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
authors.forename: Silje
authors.initials: S
authors.lastname: Nord
authors.affiliation: The Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5T 2M9.
authors.forename: Richard
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authors.lastname: Cowper-Sal Lari
authors.affiliation: 1] The Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada M5T 2M9 [2] Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire 03755, USA.
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authors.lastname: Desai
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Siddhartha
authors.initials: S
authors.lastname: Kar
authors.affiliation: 1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Hillman
authors.affiliation: 1] Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia [2] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Susanne
authors.initials: S
authors.lastname: Kaufmann
authors.affiliation: Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
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authors.initials: DM
authors.lastname: Glubb
authors.affiliation: Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4029, Australia.
authors.forename: Jonathan
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authors.lastname: Beesley
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Joe
authors.initials: J
authors.lastname: Dennis
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.initials: MK
authors.lastname: Bolla
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.initials: Q
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authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.lastname: Dicks
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
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authors.initials: MK
authors.lastname: Schmidt
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Mitul
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authors.lastname: Shah
authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
authors.forename: Robert
authors.initials: R
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authors.affiliation: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
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authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
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authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
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authors.lastname: Darabi
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
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authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
authors.forename: Daniel
authors.initials: D
authors.lastname: Klevebring
authors.affiliation: 1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark [3] Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Stig E
authors.initials: SE
authors.lastname: Bojesen
authors.affiliation: 1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark [3] Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
authors.forename: Børge G
authors.initials: BG
authors.lastname: Nordestgaard
authors.affiliation: 1] Copenhagen General Population Study, Herlev Hospital, 2730 Herlev, Copenhagen, Denmark [2] Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark.
authors.forename: Sune F
authors.initials: SF
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authors.affiliation: Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, 2730 Herlev, Copenhagen, Denmark.
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authors.forename: Diether
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authors.lastname: Lambrechts
authors.affiliation: 1] Vesalius Research Center (VRC), VIB, 3000 Leuven, Belgium [2] Vesalius Research Center, University of Leuven, 3000 Leuven, Belgium.
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authors.lastname: Thienpont
authors.affiliation: 1] Department of Oncology, University of Leuven, 3000 Leuven, Belgium [2] Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Patrick
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authors.lastname: Neven
authors.affiliation: 1] Department of Oncology, University of Leuven, 3000 Leuven, Belgium [2] Multidisciplinary Breast Center, Department of General Medical Oncology, University Hospitals Leuven, 3000 Leuven, Belgium.
authors.forename: Hans
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authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
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authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
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authors.affiliation: Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, 1066 CX Amsterdam, The Netherlands.
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authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
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authors.initials: JE
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
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authors.affiliation: Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
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authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Jenny
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authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Anja
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authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
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authors.affiliation: Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, 20246 Hamburg, Germany.
authors.forename: Dieter
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authors.lastname: Flesch-Janys
authors.affiliation: Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
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authors.affiliation: Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
authors.forename: Isabel
authors.initials: I
authors.lastname: Dos-Santos-Silva
authors.affiliation: Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
authors.forename: Lorna
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authors.affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
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authors.affiliation: Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
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authors.initials: TA
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authors.affiliation: Department of Clinical Genetics, University of Helsinki, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
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authors.affiliation: Department of Oncology, University of Helsinki, Helsinki University Central Hospital, Helsinki, FI-00029 HUS, Finland.
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authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
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authors.affiliation: Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
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authors.affiliation: Human Genetics Division, Genome Institute of Singapore, Singapore 138672, Singapore.
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authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-17177, Sweden.
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authors.affiliation: 1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea [3] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Daehee
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authors.affiliation: 1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea [2] Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 151-742, Korea [3] Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea.
authors.forename: Sue K
authors.initials: SK
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authors.affiliation: Department of Surgery, Seoul National University College of Medicine, Seoul 110-799, Korea.
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authors.affiliation: Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka 812-8582, Japan.
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authors.affiliation: Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681, Japan.
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authors.affiliation: Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya 484-8681, Japan.
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authors.affiliation: Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya 484-8681, Japan.
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authors.initials: Y
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authors.affiliation: 1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors.forename: Pascal
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authors.affiliation: 1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors.forename: Thérèse
authors.initials: T
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authors.affiliation: 1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Menegaux
authors.affiliation: 1] Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, 94807 Villejuif, France [2] University Paris-Sud, UMRS 1018, 94807 Villejuif, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Sanchez
authors.affiliation: 1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] Molecular Epidemiology Group, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.affiliation: 1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Frederik
authors.initials: F
authors.lastname: Marme
authors.affiliation: 1] Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany [2] National Center for Tumor Diseases, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Andreas
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authors.lastname: Schneeweiss
authors.affiliation: Department of Obstetrics and Gynecology, University of Heidelberg, 69120 Heidelberg, Germany.
authors.forename: Christof
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authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
authors.forename: Anna H
authors.initials: AH
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authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
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authors.initials: CC
authors.lastname: Tseng
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
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authors.lastname: Van Den Berg
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
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authors.affiliation: 1] Centro de Investigación en Red de Enfermedades Raras (CIBERER), 46010 Valencia, Spain [2] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
authors.forename: Javier
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authors.lastname: Benitez
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario La Paz, 28046 Madrid, Spain.
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authors.affiliation: Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, 33012 Oviedo, Spain.
authors.forename: Jose Ignacio Arias
authors.initials: JI
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authors.affiliation: Servicio de Anatomía Patológica, Hospital Monte Naranco, 33013 Oviedo, Spain.
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authors.lastname: Menéndez
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Shu
authors.affiliation: Shanghai Center for Disease Control and Prevention, Shanghai 200336, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China.
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Gao
authors.affiliation: Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
authors.forename: Qiuyin
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authors.affiliation: CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
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authors.initials: A
authors.lastname: Cox
authors.affiliation: Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK.
authors.forename: Simon S
authors.initials: SS
authors.lastname: Cross
authors.affiliation: CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield S10 2RX, UK.
authors.forename: Malcolm W R
authors.initials: MW
authors.lastname: Reed
authors.affiliation: 1] Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5 [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
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authors.initials: IL
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authors.affiliation: 1] Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada M5T 3M7 [2] Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
authors.forename: Julia A
authors.initials: JA
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authors.affiliation: Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
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authors.initials: G
authors.lastname: Glendon
authors.affiliation: Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.
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authors.affiliation: Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's &St Thomas' NHS Foundation Trust in partnership with King's College London, London SE1 9RT, UK.
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authors.lastname: Sawyer
authors.affiliation: Wellcome Trust Centre for Human Genetics, Oxford Biomedical Research Centre, University of Oxford, Oxford OX3 7BN, UK.
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authors.lastname: Tomlinson
authors.affiliation: Clinical Science Institute, University Hospital Galway, Galway, Ireland.
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authors.initials: MJ
authors.lastname: Kerin
authors.affiliation: Clinical Science Institute, University Hospital Galway, Galway, Ireland.
authors.forename: Nicola
authors.initials: N
authors.lastname: Miller
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Christopher A
authors.initials: CA
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authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA.
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authors.lastname: Schumacher
authors.affiliation: Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii 96813, USA.
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authors.lastname: Le Marchand
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm SE-17177, Sweden.
authors.forename: Annika
authors.initials: A
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authors.affiliation: Department of Oncology-Pathology, Karolinska Institutet, Stockholm SE-17177, Sweden.
authors.forename: Sara
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authors.lastname: Margolin
authors.affiliation: 1] Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia [2] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500 Selangor, Malaysia.
authors.forename: Soo Hwang
authors.initials: SH
authors.lastname: Teo
authors.affiliation: Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, 59100 Kuala Lumpur, Malaysia.
authors.forename: Cheng Har
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authors.affiliation: Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya 47500 Selangor, Malaysia.
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authors.lastname: Lee
authors.affiliation: Singapore Eye Research Institute, National University of Singapore, Singapore 168751, Singapore.
authors.forename: Tien Y
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authors.lastname: Wong
authors.affiliation: Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
authors.forename: Maartje J
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authors.lastname: Hooning
authors.affiliation: Department of Medical Oncology, Erasmus MC Cancer Institute, 3008 AE Rotterdam, The Netherlands.
authors.forename: John W M
authors.initials: JW
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authors.affiliation: Department of Clinical Genetics, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands.
authors.forename: J Margriet
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authors.affiliation: Department of Pathology, Erasmus University Medical Center, 3075 EA Rotterdam, The Netherlands.
authors.forename: Carolien H M
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authors.lastname: van Deurzen
authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.affiliation: Department of Pathology, The University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Helen
authors.initials: H
authors.lastname: Tsimiklis
authors.affiliation: Centre for Molecular, Environmental, Genetic and Analytical Epidemiology, Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Miroslav K
authors.initials: MK
authors.lastname: Kapuscinski
authors.affiliation: 1] College of Public Health, China Medical University, Taichung 40402, Taiwan, China [2] Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, China.
authors.forename: Chen-Yang
authors.initials: CY
authors.lastname: Shen
authors.affiliation: Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan, China.
authors.forename: Pei-Ei
authors.initials: PE
authors.lastname: Wu
authors.affiliation: Department of Surgery, Tri-Service General Hospital, Taipei 114, Taiwan, China.
authors.forename: Jyh-Cherng
authors.initials: JC
authors.lastname: Yu
authors.affiliation: Department of Surgery, Changhua Christian Hospital, Changhua City 500, Taiwan, China.
authors.forename: Shou-Tung
authors.initials: ST
authors.lastname: Chen
authors.affiliation: Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway.
authors.forename: Grethe Grenaker
authors.initials: GG
authors.lastname: Alnæs
authors.affiliation: 1] Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, N-0310 Oslo, Norway [2] Institute of Clinical Medicine, University of Oslo (UiO), 0318 Oslo, Norway.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Borresen-Dale
authors.affiliation: 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia.
authors.forename: Graham G
authors.initials: GG
authors.lastname: Giles
authors.affiliation: 1] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia [2] Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, Victoria 3053, Australia.
authors.forename: Roger L
authors.initials: RL
authors.lastname: Milne
authors.affiliation: Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria 3004, Australia.
authors.forename: Catriona
authors.initials: C
authors.lastname: McLean
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mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D045744:Cell Line, Tumor; D002843:Chromatin / Q000378:metabolism; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D051541:Hepatocyte Nuclear Factor 3-alpha / Q000378:metabolism; D006801:Humans; D018975:Insulin-Like Growth Factor Binding Protein 5 / Q000235:genetics* / Q000378:metabolism; D061986:MCF-7 Cells; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D002843:Chromatin; C496499:FOXA1 protein, human; D051541:Hepatocyte Nuclear Factor 3-alpha; D018975:Insulin-Like Growth Factor Binding Protein 5; D012333:RNA, Messenger