title: Musical hallucinations responding to a further increase of carbamazepine.
abstract: A 73-year-old woman outpatient with mild cognitive impairment, parasomnia and depressive state with musical hallucinations failed to respond to 400 mg/day of valproate. Once she was admitted to a university hospital, her musical hallucinations partially responded to 1 mg/day of clonazepam and sufficiently improved on 100 mg/day of carbamazepine. Two months after discharge, however, her musical hallucinations recurred probably as a consequence of psychological stress. The increase of carbamazepine from 100 to 200 mg/day completely remitted her musical hallucinations. This case suggests that musical hallucinations respond in a dose-dependent manner to increasing carbamazepine, and that gradual titration from small doses of carbamazepine is required because optimal doses appear to be smaller than those required for epilepsy and bipolar disorder. Further studies are warranted to determine the therapeutic levels of carbamazepine for musical hallucinations.
authors.affiliation: Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Aizawa
authors.affiliation: Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terao
authors.affiliation: Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hatano
authors.affiliation: Faculty of Medicine, Oita University, Yufu, Japan.
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Ishii
mesh_terms: D000368:Aged; D018692:Antimanic Agents / Q000008:administration & dosage; D002220:Carbamazepine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006212:Hallucinations / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging; D009146:Music
chemical_list: D018692:Antimanic Agents; D002220:Carbamazepine