title: [Mucosal changes in the periulcer zone and endocrine system in patients with gastroduodenal ulcer, complicated by hemorrhage].
abstract: Examination of patients, suffering gastroduodenal ulcer, complicated by hemorrhage, was conducted, using clinical, microbiological, immunohistochemical methods and chromatomassspectrography. Enhanced activity of inducible NO-synthase, contamination of periulcer zone with microorganisms Klebsiella pneumoniae, Streptococcus beta-haemoliticus, enhancement of contents of catecholamines and serotonin in the blood serum were revealed. These changes are most expressed in severe blood loss, unstable local endoscopic hemostasis, high risk of a recurrent hemorrhage occurrence. The data obtained permit to prognosticate severity of a pathologic process course and to improve the treatment programe.
authors.forename: M V
authors.initials: MV
authors.lastname: Trofimov
mesh_terms: D002395:Catecholamines / Q000097:blood; D004703:Endocrine System / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010437:Peptic Ulcer / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D010438:Peptic Ulcer Hemorrhage / Q000097:blood / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D012701:Serotonin / Q000097:blood; D012720:Severity of Illness Index; D013291:Streptococcus / Q000302:isolation & purification
chemical_list: D002395:Catecholamines; D012701:Serotonin; C496319:NOS2 protein, human; D052247:Nitric Oxide Synthase Type II