title: Evaluation of paraoxonase and arylesterase activities in patients with irritable bowel syndrome.
abstract: The aims of the present study were to evaluate oxidative status, by investigating the serum Paraoxonase/Arylesterase (PON/ARE) activities along with conjugated dienes in patients with IBS and controls and to confirm the link between oxidative stress and IBS. Thirty IBS patient and 30 healthy subjects were recruited. Total serum cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), PON and ARE activities and conjugated dienes levels were measured. Mean serum PON1 activity was lower in IBS group compared to that of the control group whereas there was no significant difference in ARE activity between IBS and control groups (p < 0.000, p < 0.716, respectively). Serum conjugated diene levels of the IBS group was significantly higher than that of the control group (p < 0.01). The drop in PON activity accompanied with an increase in conjugated diene levels indicate the presence of oxidative stress, a disturbance in prooxidant - antioxidant balance and increased inflammation in IBS patients.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Oran
authors.forename: Feti
authors.initials: F
authors.lastname: Tulubas
authors.forename: Rafet
authors.initials: R
authors.lastname: Mete
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.forename: Hatice Gul
authors.initials: HG
authors.lastname: Sarikaya
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gurel
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human