title: Acquired hemophilia A in the HIV-infected patient: a case report and literature review.
abstract: Acquired hemophilia A is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Spontaneous bleeding in the various sites and severity is the most common clinical presentation. Here, we report a 74-year-old Thai woman with HIV infection who presented with spontaneous ecchymoses. The laboratory revealed isolated activated partial thromboplastin time prolongation with low FVIII activity and a presence of FVIII inhibitor. She was diagnosed with acquired hemophilia A. Corticosteroid monotherapy was the treatment regimen for inhibitor eradication. We demonstrate the clinical course of the rare condition and review the relevant literature.
authors.affiliation: Division of Hematology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Thanawat
authors.initials: T
authors.lastname: Rattanathammethee
authors.forename: Lalita
authors.initials: L
authors.lastname: Norasetthada
authors.forename: Adisak
authors.initials: A
authors.lastname: Tantiworawit
authors.forename: Ekarat
authors.initials: E
authors.lastname: Rattarittamrong
authors.forename: Sasinee
authors.initials: S
authors.lastname: Hantrakool
authors.forename: Chatree
authors.initials: C
authors.lastname: Chai-Adisaksopha
mesh_terms: D000368:Aged; D004438:Ecchymosis / Q000097:blood / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000097:blood*; D006467:Hemophilia A / Q000821:virology*; D006801:Humans