title: EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data.
abstract: The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i) statistical methods to test and account for between-strata difference as a means to tackle gene-strata interaction effects and (ii) extended graphical features tailored for stratified GWAMA results. The software provides further features also suitable for general GWAMAs including functions to annotate, exclude or highlight specific loci in plots or to extract independent subsets of loci from genome-wide datasets. It is freely available and includes a user-friendly scripting interface that simplifies data handling and allows for combining statistical and graphical functions in a flexible fashion.
  
  
  BACKGROUND
  EasyStrata is available for free (under the GNU General Public License v3) from our Web site www.genepi-regensburg.de/easystrata and from the CRAN R package repository cran.r-project.org/web/packages/EasyStrata/.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Winkler
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbr
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kutalik
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.
authors.forename: Mathias
authors.initials: M
authors.lastname: Gorski
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.
authors.forename: Claudio
authors.initials: C
authors.lastname: Lottaz
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.
authors.forename: Florian
authors.initials: F
authors.lastname: Kronenberg
authors.affiliation: Department of Genetic Epidemiology, University of Regensburg, D-93053 Regensburg, Germany, Department of Medical Genetics, University of Lausanne, CH-1005 Lausanne, Switzerland, Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), CH-1010 Lausanne, Switzerland, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland, Department of Statistical Bioinformatics, Institute for Functional Genomics, University of Regensburg, D-93053 Regensburg, Germany and Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria.
authors.forename: Iris M
authors.initials: IM
authors.lastname: Heid
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D066264:Datasets as Topic; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D015201:Meta-Analysis as Topic; D012984:Software