title: Synthesis of ferrocene derivatives with planar chirality via palladium-catalyzed enantioselective C-H bond activation.
abstract: The first catalytic and enantioselective C-H direct acylation of ferrocene derivatives has been developed. A series of 2-acyl-1-dimethylaminomethylferrocenes with planar chirality were provided under highly efficient and concise one-pot conditions with up to 85% yield and 98% ee. The products obtained could be easily converted to various chiral ligands via diverse transformations.
authors.affiliation: Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Department of Chemistry, Zhengzhou University , Zhengzhou 450052, P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Pi
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
authors.forename: Xiuyan
authors.initials: X
authors.lastname: Liu
authors.forename: Mengxing
authors.initials: M
authors.lastname: Guo
authors.forename: Hanyu
authors.initials: H
authors.lastname: Zhang
authors.forename: Yangjie
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000215:Acylation; D002384:Catalysis; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D000075163:Metallocenes; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005296:Ferrous Compounds; D008024:Ligands; D000075163:Metallocenes; D010165:Palladium; C004998:ferrocene