title: Synthesis of [(18) O2 ]-curcumin.
abstract: Curcumin, a pigment isolated from rhizomes of Curcuma longa, is a potent cancer chemopreventive and chemotherapeutic agent and is now evaluated in phase III human clinical trials. This report describes an efficient synthesis of [(18) O2 ]-curcumin. [(18) O2 ]-Curcumin was prepared in three steps from 1-iodo-2-methoxy-4-methylbenzene in an overall yield of 53%.
authors.affiliation: School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, 100081, China.
authors.forename: Xiurui
authors.initials: X
authors.lastname: Shen
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xihuan
authors.initials: X
authors.lastname: Liu
authors.forename: Hongliang
authors.initials: H
authors.lastname: Wen
mesh_terms: D003474:Curcumin / Q000138:chemical synthesis* / Q000494:pharmacology; D010103:Oxygen Isotopes / Q000737:chemistry; D010104:Oxygen Radioisotopes
chemical_list: D010103:Oxygen Isotopes; D010104:Oxygen Radioisotopes; D003474:Curcumin
keywords: 18O-labelling; curcumin; hydroxylation; synthesis