title: Impact of the prolymphangiogenic crosstalk in the tumor microenvironment on lymphatic cancer metastasis.
abstract: Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also by cells of the tumor microenvironment, including cancer associated fibroblasts, mesenchymal stem cells, dendritic cells, or macrophages. Even the extracellular matrix as well as cytokines and growth factors are involved in the process of lymphangiogenesis and metastasis. The cellular and noncellular components influence each other and can be influenced by the tumor cells. The knowledge about mechanisms behind lymphangiogenesis in the tumor microenvironmental crosstalk is growing and offers starting points for new therapeutic approaches.
authors.affiliation: Department of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
authors.forename: Simona L
authors.identifier: 0000-0002-7230-6434
authors.initials: SL
authors.lastname: Schlereth
authors.affiliation: Department of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
authors.forename: Nasrin
authors.identifier: 0000-0001-8345-5972
authors.initials: N
authors.lastname: Refaian
authors.affiliation: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Straße 26, 50931 Cologne, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Iden
authors.affiliation: Department of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
authors.forename: Claus
authors.initials: C
authors.lastname: Cursiefen
authors.affiliation: Department of Ophthalmology, University of Cologne, Kerpener Straße 62, 50937 Cologne, Germany.
authors.forename: Ludwig M
authors.initials: LM
authors.lastname: Heindl
mesh_terms: D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology; D006801:Humans; D042583:Lymphangiogenesis / Q000235:genetics*; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D042601:Lymphatic Vessels / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment / Q000235:genetics*