title: Long non-coding RNAs and control of gene expression in the immune system.
abstract: All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.
authors.affiliation: Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
authors.forename: Maninjay K
authors.initials: MK
authors.lastname: Atianand
authors.affiliation: Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA. Electronic address: kate.fitzgerald@umassmed.edu.
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Fitzgerald
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007109:Immunity / Q000235:genetics*; D062085:RNA, Long Noncoding
chemical_list: D062085:RNA, Long Noncoding
keywords: epigenetics; gene expression; innate immunity; lincRNA; lncRNA; long non-coding RNA