title: The relationship between AASI and arterial atherosclerosis in ESRD patients.
abstract: OBJECTIVE
  To explore the relationship between ambulatory blood pressure and arterial atherosclerosis and provide simple and easy reference indicators for the prediction, prevention and prognosis of cardiovascular events in end-stage renal disease (ESRD) patients.
  
  
  METHODS
  This prospective study consecutively collected clinical data of 114 ESRD hospitalized patients in the Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University during August 2012 to December 2012. The data included laboratory data, the ambulatory blood pressure monitoring (ABPM), carotid ultrasound, two-dimensional echocardiography and the prognosis scores of the death risk.
  
  
  RESULTS
  (1) A series of ABPM parameters were closely associated with atherosclerosis (p ≤ 0.05). Ambulatory Arterial Stiffness Index (AASI) was the most representative parameter of ABPM and also the best indicator for atherosclerosis (logistic regression analysis, p = 0.005). (2) AASI was a comprehensive index of atherosclerosis (p < 0.001), which was associated with the increase of left ventricular diameter (p = 0.028) and the risk of death (p < 0.001). The independent risk factors of AASI were the growth of the age (p < 0.001), elevated serum fibrinogen (p = 0.009) and reduced serum albumin (p = 0.022).
  
  
  CONCLUSIONS
  AASI, as the representative of ABPM parameters, related well to atherosclerosis, which implied a broader application of ABPM in ESRD patients.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University , Nanjing , China and.
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Hui-Juan
authors.initials: HJ
authors.lastname: Mao
authors.forename: Bing
authors.initials: B
authors.lastname: Sun
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zeng
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Xiang-Bao
authors.initials: XB
authors.lastname: Yu
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Chang-Ying
authors.initials: CY
authors.lastname: Xing
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D002339:Carotid Arteries / Q000000981:diagnostic imaging; D002681:China; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D059289:Vascular Stiffness
keywords: AASI; ABPM; ESRD; atherosclerosis