title: Investigating the link between particulate exposure and airway inflammation in the horse.
abstract: Inhalant exposure to airborne irritants commonly encountered in horse stables is implicated in the pathogenesis of inflammatory airway disease (IAD) and recurrent airway obstruction (RAO), non-infectious, inflammatory pulmonary disorders that impact the health and performance of horses across all equine disciplines. IAD and RAO have overlapping clinical, cytological, and functional manifestations of the pulmonary response to organic dust and noxious gases encountered in the barn environment. Study of these diseases has provided important but incomplete understanding of the effect of air quality upon the respiratory health of horses. In this review, the principles of particulate exposure assessment, including health-related aerosol size fractions and size-selective sampling, the factors influencing air quality in equine environments, and the effect of air quality on the equine respiratory tract are discussed. The objective of this review is to provide the reader with a summary of the most common chronic inflammatory airway diseases in the horse and the principles of air sampling that are essential to the planning, interpretation, and assessment of equine respiratory health-related exposure studies.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, IN.
authors.forename: K M
authors.initials: KM
authors.lastname: Ivester
authors.forename: L L
authors.initials: LL
authors.lastname: Couëtil
authors.forename: N J
authors.initials: NJ
authors.lastname: Zimmerman
mesh_terms: D000818:Animals; D004781:Environmental Exposure / Q000009:adverse effects; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D007249:Inflammation / Q000139:chemically induced / Q000662:veterinary*; D052638:Particulate Matter / Q000009:adverse effects*; D012137:Respiratory System / Q000187:drug effects; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D052638:Particulate Matter
keywords: Aerosol sampling; Dust; Endotoxin; Inflammatory airway disease; Recurrent airway obstruction