title: [Effects of alkaloids from coptidis rhizoma on blood lipid metabolism and low-denstity lipoprotein receptor mRNA in golden hamsters].
abstract: To study the effects of alkaloids from Coptidis Rhizoma on low-density lipoprotein receptor (LDLR) mRNA expression and antihyperlipedemic levels. The LDLR mRNA expression were detected by real time fluorescence quantitative PCR, and the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in serum were measured at the first and last examination. The results show that, after the drug treatment, compared with the model group, each drug group showed a lipid-lowering effect. Especially, coptisine, palmatine, jatrorrhinze were significantly reduced TC, TG, LDL-c (P < 0.05, P < 0.01), and increased HDL-c (P < 0.01). In addition, they also increased mRNA expression of the LDLR in liver and HepG2 cells. The results showed that alkaloids from Coptidis Rhizoma can regulate lipid metabolism disorder, and coptisine have the best lipid-lowering effect.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Yan-Zhi
authors.initials: YZ
authors.lastname: Wang
authors.forename: De-Zhen
authors.initials: DZ
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Pang
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Ye
authors.forename: Xue-Gang
authors.initials: XG
authors.lastname: Li
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage*; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D000089042:Coptis chinensis; D006224:Cricetinae; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000378:metabolism; D008647:Mesocricetus; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D008055:Lipids; D008077:Lipoproteins, LDL; D018110:Receptors, Lipoprotein; D014280:Triglycerides; D002784:Cholesterol; C107393:Coptidis rhizoma extract