title: Liposome-based approaches for delivery of mainstream chemotherapeutics: preparation methods, liposome designs, therapeutic efficacy.
abstract: We review liposome-based delivery approaches that aim to address toxicities and to improve the therapeutic efficacy of mainstream chemotherapeutics, namely, doxorubicin, paclitaxel, and cisplatin. A brief review of the biomolecular mechanism(s) of action of these agents is followed by a description of characteristic examples of therapeutic approaches and of liposome membrane designs. Short reports on clinical studies are also included when applicable. The technical issues of different loading/encapsulation methods of these agents into liposomes are also discussed in terms of the physicochemical properties of both the agents themselves and of the lipid-based self-assemblies.
authors.affiliation: Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.
authors.forename: Michelle
authors.initials: M
authors.lastname: Sempkowski
authors.affiliation: Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ.
authors.forename: Trevan
authors.initials: T
authors.lastname: Locke
authors.affiliation: Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ.
authors.forename: Sally
authors.initials: S
authors.lastname: Stras
authors.affiliation: Department of Biomedical Engineering, Rutgers University, Piscataway, NJ.
authors.forename: Charles
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Department of Biomedical Engineering, Rutgers University, Piscataway, NJ; Department of Chemical and Biochemical Engineering, Rutgers University, Piscataway, NJ.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Sofou
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D066246:ErbB Receptors / Q000276:immunology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes; D017239:Paclitaxel / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D008081:Liposomes; D004317:Doxorubicin; D066246:ErbB Receptors; D017239:Paclitaxel; D002945:Cisplatin