title: Lewis basicity modulation of N-heterocycles: a key for successful cross-metathesis.
abstract: Cross-metathesis involving N-heteroaromatic olefinic derivatives is disclosed. The introduction of an appropriate substituent on the heteroaromatic ring decreases the Lewis basicity of the nitrogen atom, thus preventing the deactivation of the ruthenium-centered catalyst. The reaction is quite general in terms of both N-heterocycles and olefinic partners.
authors.affiliation: Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL* Research University , 10, rue Vauquelin 75231 Paris Cedex 05, France.
authors.forename: Kevin
authors.initials: K
authors.lastname: Lafaye
authors.forename: Lionel
authors.initials: L
authors.lastname: Nicolas
authors.forename: Amandine
authors.initials: A
authors.lastname: Guérinot
authors.forename: Sébastien
authors.initials: S
authors.lastname: Reymond
authors.forename: Janine
authors.initials: J
authors.lastname: Cossy
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D011725:Pyridines; D012428:Ruthenium