title: Mucoadhesive beads of gellan gum/pectin intended to controlled delivery of drugs.
abstract: Gellan gum/pectin beads were prepared by ionotropic gelation, using Al(3+) as crosslinker. High yield (92.76%) and entrapment efficiency (52.22-88.78%) were reached. Beads exhibited high circularity (0.730-0.849) and size between 728.95 and 924.56 μm. Particle size and circularity was increased by raising polymer and crosslinker concentrations. Polymers ratio did not influence beads properties. The materials stability and the absence of drug-polymers interactions were evidenced by thermal analysis and FTIR. The high beads mucoadhesiveness was evidenced by in vitro and ex vivo tests. The erosion of beads was greater in acid media while swelling was more pronounced in pH 7.4. Drug release was dependent on pH in which samples 11H1-3, 11H1-5 and 41H1-3 released only 34%, 20% and 22% of ketoprofen in pH 1.2, while in pH 7.4 the drug release was sustained up to 360 min. Korsmeyer-Peppas model demonstrated that drug release occurred according to super case-II transport.
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, São Paulo State University-UNESP, Rodovia Araraquara-Jaú, km 1, Zip Code 14801-902, Araraquara, SP, Brazil. Electronic address: fabiolagp@gmail.com.
authors.forename: Fabíola Garavello
authors.initials: FG
authors.lastname: Prezotti
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, São Paulo State University-UNESP, Rodovia Araraquara-Jaú, km 1, Zip Code 14801-902, Araraquara, SP, Brazil. Electronic address: curybsf@fcfar.unesp.br.
authors.forename: Beatriz Stringhetti Ferreira
authors.initials: BS
authors.lastname: Cury
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, São Paulo State University-UNESP, Rodovia Araraquara-Jaú, km 1, Zip Code 14801-902, Araraquara, SP, Brazil.
authors.forename: Raul Cesar
authors.initials: RC
authors.lastname: Evangelista
mesh_terms: D000269:Adhesives / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000378:metabolism; D004337:Drug Carriers / Q000008:administration & dosage / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D010368:Pectins / Q000008:administration & dosage / Q000378:metabolism*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000378:metabolism*; D013552:Swine
chemical_list: D000269:Adhesives; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D010368:Pectins
keywords: Beads; Controlled release; Gellan gum; Ionotropic gelation; Ketoprofen; Pectin