title: Prognostic factors obtained from long-term follow-up of pituitary adenomas and other sellar tumors.
abstract: OBJECTIVE
  Pituitary adenomas do not have a single factor of aggressive behavior or recurrence. The objective of this study was to determine factors influencing the prognosis in pituitary adenomas.
  
  
  METHODS
  243 patients who were operated between January 2000 and June 2012 were included in this retrospective study. Demographic data, age at diagnosis, date of diagnosis, date of operation, type of operation, post-operative medications, pre- and postoperative hormone levels, and MRI findings were evaluated in each patient.
  
  
  RESULTS
  The rate of total resection of sellar tumors was less than 50% in our patient population. The prognosis was better in cases with total resection. Tumor size was a poor prognostic factor in sellar tumors. Female sex was a poor prognostic factor in acromegaly and male sex in prolactinoma. The prognosis was worse in patients with cavernous sinus invasion. In acromegaly, pre-operative level of 850 ng/ml for IGF-1 was noted as a possible prognostic cut-off value.
  
  
  CONCLUSIONS
  Long-term follow-up results of our study suggest that factors common to all sellar tumors including tumor type, tumor size, total resection, and cavernous sinus invasion and tumor type-specific factors including sex and hormone levels play important roles in the prognosis.
authors.affiliation: Erciyes University, School of Medicine, Department of Endocrinology, Kayseri, Turkey.
authors.forename: Halit
authors.initials: H
authors.lastname: Diri
authors.forename: Ersin
authors.initials: E
authors.lastname: Ozaslan
authors.forename: Ali
authors.initials: A
authors.lastname: Kurtsoy
authors.forename: Bulent
authors.initials: B
authors.lastname: Tucer
authors.forename: Yasin
authors.initials: Y
authors.lastname: Simsek
authors.forename: Figen
authors.initials: F
authors.lastname: Ozturk
authors.forename: Ahmet Candan
authors.initials: AC
authors.lastname: Durak
authors.forename: Fahri
authors.initials: F
authors.lastname: Bayram
mesh_terms: D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002426:Cavernous Sinus / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010907:Pituitary Hormones / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D010907:Pituitary Hormones