title: Effect of predictive value of progesterone level on the day of HCG injection for IVF success in women with infertility due to tubal factor or polycystic ovarian syndrome referred to the women hospital, Tehran, 2009.
abstract: BACKGROUND
  Polycystic ovarian syndrome is one of the most common causes of endocrine disorders and main reason of infertility due to anovulation and recurrent abortions. Progesterone has been shown to have an important role in fertilization of oocyte and fetal implantation.
  
  
  OBJECTIVE
  The purpose of this study was to compare the predictive value of progesterone level on IVF success in women with infertility due to tubal factor or PCOS.
  
  
  METHODS
  In a stratified cohort study, we assigned 76 infertile women of 20-38 years old who referred to women hospital into two equal groups with fallopian tube factor infertility and PCOS. We measured the plasma levels of progesterone and estradiol on the day of HCG administration. The patients were divided into two groups based on progesterone level cut off point of 1.2ng/ml. Thereafter the incidence of pregnancy (chemical by β-HCG measurement and clinical by ultrasonography up to the 6 weeks after fetal transfer) was compared in these groups.
  
  
  RESULTS
  Total pregnancy rates were 15.8% in patients with tubal factor infertility and 26.3% in women with PCOS. In women with PCOS, the pregnancy rate was less in patients with progesterone level <1.2 ng/ml. However this difference was not statistically significant. Likewise, we did not observe any significant differences in pregnancy rate in patients with fallopian tube factor infertility.
  
  
  CONCLUSIONS
  Serum progesterone level on the day of HCG administration is not well predictive of the IVF success in infertile women due to fallopian tube factor or PCOS. To obtain more uniform results, we recommend use of larger samples while the bias variable is taken into account and the ROC curve is used for determination of the unique serum progesterone level.
authors.affiliation: Department of Obstetrics and Gynecology, Mirza Kouchakkhan Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Azizeh
authors.initials: A
authors.lastname: Ghaseminejad
authors.affiliation: Department of Obstetrics and Gynecology, Mirza Kouchakkhan Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaee
authors.affiliation: Department of Obstetrics and Gynecology, Mirza Kouchakkhan Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Forootan
authors.affiliation: Department of Obstetrics and Gynecology, Mirza Kouchakkhan Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Taraneh
authors.initials: T
authors.lastname: Hosseinipoor
authors.affiliation: Department of Obstetrics and Gynecology, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Forghani
authors.affiliation: Hormozgan Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandarabbas, Iran.
authors.forename: Pooneh
authors.initials: P
authors.lastname: Nikuei
keywords: IVF; Infertility; PCOS; Serum progesterone Level; Tubal factor