title: Long-term effects of varying consumption of ω3 fatty acids in ear, nose and throat cancer patients: assessment 1 year after radiotherapy.
abstract: A prospective 1-year follow-up study in ear, nose, and throat (ENT) cancer patients was carried out one year after radiotherapy to assess the effect of varying consumption of ω3 fatty acid according to whether they consumed more or less than the 50th percentile of ω3 fatty acids. Clinical, analytical, inflammatory (CRP and IL-6), and oxidative variables (TAC, GPx, GST, and SOD) were evaluated. The study comprised 31 patients (87.1% men), with a mean age of 61.3 ± 9.1 years. Hematological variables showed significant differences in the patients with a lower consumption of ω3 fatty acids. A lower mortality and longer survival were found in the group with ω3 fatty acid consumption ≥50th percentile but the differences were not significant. No significant difference was reached in toxicity, inflammation, and oxidative stress markers. The group with ω3 fatty acid consumption <50th percentile significantly experienced more hematological and immune changes.
authors.affiliation: Biomedical Research Institute of Malaga (IBIMA), Virgen de la Victoria Hospital, University of Malaga , Málaga , Spain .
authors.forename: María Del Mar
authors.initials: Mdel M
authors.lastname: Roca-Rodríguez
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: García-Almeida
authors.forename: Josefina
authors.initials: J
authors.lastname: Ruiz-Nava
authors.forename: Juan
authors.initials: J
authors.lastname: Alcaide
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Lupiañez-Pérez
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Rico-Pérez
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Toledo-Serrano
authors.forename: Fernando
authors.initials: F
authors.lastname: Cardona
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Medina-Carmona
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D004032:Diet; D002149:Energy Intake; D004734:Energy Metabolism; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000097:blood*; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies
chemical_list: D015525:Fatty Acids, Omega-3; D015850:Interleukin-6; D002097:C-Reactive Protein
keywords: Cancer; clinical study; metabolic status; nutritional supplement; survival