title: Changes in maternal blood inflammatory markers as a predictor of chorioamnionitis: a prospective multicenter study.
abstract: OBJECTIVE
  To evaluate the inflammatory pattern in maternal circulation from women with preterm premature rupture of membranes (PPROM) considering the occurrence of histologically confirmed chorioamnionitis (HCA).
  
  
  METHODS
  A prospective study was conducted in 121 women with PPROM between 24 and 34 + 0 weeks of gestation. Association between white blood cells (WBC) count, plasma CRP, IL-6, MCP-1 and IP-10 levels, and HCA was assessed.
  
  
  RESULTS
  The rate of HCA was 44.7% (54/121). During the 5 days preceding delivery, median CRP, WBC, and IL-6 levels were significantly higher in the HCA than in no-HCA group (P < 0.001). Variations in IL-6, IP-10 levels, during the 24-72 hr before delivery, were predictors of the occurrence of HCA, but the diagnostic accuracy was low [Receiver Operating Characterictic (ROC) curve, area under the curve (AUC) = 0.56].
  
  
  CONCLUSIONS
  An increase in IL-6, CRP, IP-10 maternal plasma levels was confirmed in PPROM women with HCA. Longitudinal follow-up of these markers did not add valuable information regarding HCA.
authors.affiliation: Centre d'Investigations Cliniques 1432 (INSERM CIC 1432), CHU Dijon, Dijon Cedex, France; Université de Bourgogne, Dijon, France; Réseau National Gynécologie et Obstétrique des CIC de l'INSERM, GO-CIC.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Le Ray
authors.forename: Guillaume
authors.initials: G
authors.lastname: Mace
authors.forename: Mourad
authors.initials: M
authors.lastname: Sediki
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lirussi
authors.forename: Didier
authors.initials: D
authors.lastname: Riethmuller
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lentz
authors.forename: Rajeev
authors.initials: R
authors.lastname: Ramanah
authors.forename: Toufic
authors.initials: T
authors.lastname: Hoyek
authors.forename: Gilles
authors.initials: G
authors.lastname: Spagnolo
authors.forename: Nicole
authors.initials: N
authors.lastname: Laurent
authors.forename: Françoise
authors.initials: F
authors.lastname: Goirand
authors.forename: Paul
authors.initials: P
authors.lastname: Sagot
authors.forename: Marc
authors.initials: M
authors.lastname: Bardou
mesh_terms: D000328:Adult; D000650:Amnion / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000276:immunology; D016207:Cytokines / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007958:Leukocyte Count; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000276:immunology; D021041:Placental Circulation / Q000276:immunology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D012421:Rupture / Q000175:diagnosis* / Q000276:immunology
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: Chorioamnionitis; IL-6; IP-10; MCP-1; PPROM; cohort study