title: Deep, dark secrets of melatonin in animal evolution.
abstract: Tosches et al. show that melatonin signaling regulates circadian swimming in annelid worms by rhythmically activating cholinergic neurons. This suggests an evolutionary connection between melatonin signaling in invertebrates and sleep regulation in vertebrates.
authors.affiliation: Department of Biological Sciences, University of Denver, Denver, CO 80208, USA.
authors.forename: Klaske J
authors.initials: KJ
authors.lastname: Schippers
authors.affiliation: Department of Biological Sciences, University of Denver, Denver, CO 80208, USA. Electronic address: scott.nichols@du.edu.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Nichols
mesh_terms: D000818:Animals; D008550:Melatonin / Q000378:metabolism*; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism*; D011077:Polychaeta / Q000502:physiology*
chemical_list: D008550:Melatonin