title: Recent progress on liver kinase B1 (LKB1): expression, regulation, downstream signaling and cancer suppressive function.
abstract: Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification. LKB1 dowcnstream pathways mainly include AMPK, microtubule affinity regulating kinase (MARK), salt-inducible kinase (SIK), sucrose non-fermenting protein-related kinase (SNRK) and brain selective kinase (BRSK) signalings, etc. This review, therefore, mainly discusses recent studies about the expression, regulation, downstream signaling and cancer suppressive function of LKB1, which can be helpful for better understanding of this molecular and its significance in cancers.
authors.affiliation: School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China. ganry@connect.hku.hk.
authors.forename: Ren-You
authors.initials: RY
authors.lastname: Gan
authors.affiliation: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. lihuabin@mail.sysu.edu.cn.
authors.forename: Hua-Bin
authors.initials: HB
authors.lastname: Li
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases; D000818:Animals; D002453:Cell Cycle; D016923:Cell Death; D015971:Gene Expression Regulation, Enzymologic; D012739:Gonadal Steroid Hormones / Q000502:physiology; D059165:Hormesis; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D018832:Molecular Chaperones / Q000378:metabolism; D009362:Neoplasm Metastasis; D010580:Peutz-Jeghers Syndrome / Q000201:enzymology* / Q000235:genetics; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D025941:Protein Interaction Mapping; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D012739:Gonadal Steroid Hormones; D018832:Molecular Chaperones; D025521:Tumor Suppressor Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; C491654:Stk11 protein, mouse; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases