title: Preparation of polypseudorotaxanes composed of cyclodextrin and polymers in microspheres.
abstract: We prepared polypseudorotaxanes (PPRXs) composed of cyclodextrin (CyD) and polyethylene glycol (PEG) inside microspheres (MSs) by an emulsifying process using polypropylene glycol (PPG) that shows temperature-dependent hydrophilicity changes; PPG is hydrophobic at high temperatures but hydrophilic at low temperatures. An aqueous solution of CyD and PEG was dispersed as droplets in PPG at 60°C then cooled to 0°C to allow water of droplets to transfer into PPG. On removal of water in the droplets, CyD and PEG were left behind as a CyD/PEG PPRX inside the solid-state MSs. Examination of α-, β-, and γ-CyD revealed that α-CyD was suitable for the formation of PPRX containing PEG in this MS preparation procedure. Interestingly, a new PPRX composed of α-CyD and PPG was formed in the α-CyD MSs when they were prepared in the absence of PEG from the aqueous solution of α-CyD. This MS fabrication procedure can control the size and shape of PPRX particles, and will contribute to the production of new types of CyD inclusion complexes.
authors.affiliation: Department of Pharmacy Services, Saitama Medical Center, Saitama Medical University.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Shinohara
authors.forename: Miki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Wataru
authors.initials: W
authors.lastname: Uchida
authors.forename: Chie
authors.initials: C
authors.lastname: Okabe
authors.forename: Shinji
authors.initials: S
authors.lastname: Oshima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sugino
authors.forename: Yuya
authors.initials: Y
authors.lastname: Egawa
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Miki
authors.forename: Osamu
authors.initials: O
authors.lastname: Hosoya
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujihara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ishimaru
authors.forename: Tohru
authors.initials: T
authors.lastname: Kishino
authors.forename: Toshinobu
authors.initials: T
authors.lastname: Seki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Juni
mesh_terms: D003505:Cyclodextrins / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D043862:Rotaxanes / Q000138:chemical synthesis / Q000737:chemistry*; D013696:Temperature
chemical_list: D003505:Cyclodextrins; D004337:Drug Carriers; D011108:Polymers; D011409:Propylene Glycols; D043862:Rotaxanes; C012504:polypropylene glycol