title: Zinc-mediated one-pot tandem reaction of nitriles with propargyl bromides: an access to 3-alkynylpyridines.
abstract: A one-pot procedure for the synthesis of 3-alkynylpyridines via a zinc-mediated tandem reaction of nitriles with propargyl bromides under extremely mild reaction conditions has been developed. This reaction exhibits high efficiency, broad substrate scope, and good functional group tolerance. In addition, the 3-alkynylpyridines obtained herein were found to be versatile and convenient intermediates for the preparation of fused-heterocyclic compounds with potential biological and material interests.
authors.affiliation: School of Environment, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Henan Key Laboratory for Environmental Pollution Control, Henan Normal University , Xinxiang, Henan 453007, P. R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: He
authors.forename: Shenghai
authors.initials: S
authors.lastname: Guo
authors.forename: Xinying
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuesen
authors.initials: X
authors.lastname: Fan
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006571:Heterocyclic Compounds; D009570:Nitriles; D011725:Pyridines; D010293:Pargyline; C458239:propargyl bromide; D015032:Zinc