title: [Clinical significance of hepatitis B virus S gene mutation for recurrence of hepatitis B after liver transplantation].
abstract: OBJECTIVE
  To examine the incidence of hepatitis B virus (HBV) S gene mutation in recipients with recurrent HBV infection after liver transplantation (LT) and to evaluate the clinical significance of these mutants.
  
  
  METHODS
  Two-hundred-and-ninety-nine patients who received LT for HBV-related liver diseases in single centre were enrolled in the study and followed up. Serum HBV DNA was amplified by fluorescence quantitative polymerase chain reaction, and HBV-S gene mutation was detected by Sanger's enzymatic method.
  
  
  RESULTS
  Twelve of the 299 patients developed recurrent HBV after LT, and 2 of these 12 carried a mutant of the HBV-S gene (incidence rate of 16.67%). One of the patients had T126I and G145A mutations, and the other had a M 133L mutation. Cox regression modelling identified the risk factors of HBV recurrence after LT as HBV-YMDD mutants (P =0.01), HBV-S mutants (P =0.03) and compliance decrease (P =0.03).
  
  
  CONCLUSIONS
  HBV-S mutants may contribute to recurrence of HBV after LT, and the mechanism should be addressed in future studies.
authors.affiliation: General Surgery Department One, Lanzhou University Second Hospital, Lanzhou, 730030 China.
authors.forename: Zuoyi
authors.initials: Z
authors.lastname: Jiao
authors.forename: Donghong
authors.initials: D
authors.lastname: Zhang
authors.forename: YmMin
authors.initials: Y
authors.lastname: Li
authors.forename: Changjiang
authors.initials: C
authors.lastname: Luo
authors.forename: Lvnan
authors.initials: L
authors.lastname: Yan
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000235:genetics*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011184:Postoperative Period; D012008:Recurrence; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D004279:DNA, Viral; C118669:S envelope protein, hepatitis B virus; D014759:Viral Envelope Proteins