title: A new isoflavonoid from seeds of Lepidium sativum L. and its protective effect on hepatotoxicity induced by paracetamol in male rats.
abstract: A new isoflavonoid, 5,6-dimethoxy-2',3'-methylenedioxy-7-C-β-d-gluco-pyranosyl isoflavone was isolated from the seeds of Lepidium sativum L. along with two known isoflavonoids, 7-hydroxy-4',5,6-trimethoxyisoflavone and 7-hydroxy-5,6-dimethoxy-2',3'-methylenedioxyisoflavone. The structures of all compounds were elucidated with NMR spectrometry. Compounds 1, 2 and the new isoflavonoid 3 were evaluated for their ability to reduce the hepatotoxicity induced by paracetamol in male rats by reducing the damage and toxicity effects on liver cells with a significant improvement of total antioxidant capacity, normalizing the levels of liver enzymes GSH, SOD, GPX, CAT and GST compared to control group.
authors.affiliation: Department of Chemistry, Faculty of Science, Tanta University, Tanta 31527, Egypt. msakran2011@gmail.com.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Sakran
authors.affiliation: Faculty of Specific Education, Zagazig University, Zagazig 44519, Egypt. y2selem@yahoo.com.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Selim
authors.affiliation: Department of Home Economics, Faculty of Specific Education, Kafr ElSheikh University, Kafr ElSheikh 33516, Egypt. nahlasalah2008@yahoo.com.
authors.forename: Nahla
authors.initials: N
authors.lastname: Zidan
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology / Q000517:prevention & control; D004195:Disease Models, Animal; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology*; D031220:Lepidium sativum / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D020011:Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D012639:Seeds / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D007529:Isoflavones; D010936:Plant Extracts; D020011:Protective Agents; D000082:Acetaminophen