title: A study of the effects of physical dermabrasion combined with chemical peeling in porcine skin.
abstract: BACKGROUND
  Many comparative studies of chemical peeling and dermabrasion have been reported. However, rare basic scientific data about the immediate effects after combined treatment with chemical peeling and dermabrasion have been confirmed.
  
  
  OBJECTIVE
  The aim of this study is to evaluate the effect of the application of physical abrasion in combination with chemical peels.
  
  
  METHODS
  Three pigs were treated with physical abrasion using a water jet device in combination with an α-hydroxy acid solution, and the skin samples of the control received chemical peeling solution alone. The levels of growth factors and neuropeptides were measured with a multiplex immunoassay.
  
  
  RESULTS
  Skin treated with physical dermabrasion combined with chemical peeling showed prominent detachment and swelling of the stratum corneum (SC), and fluid collection in the hair follicles. The mean cell count of CD34 positive fibroblasts and mast cells, levels of epidermal growth factor, fibroblast growth factor-2, vascular endothelial growth factor, and neurotensin, were significantly increased in the tissue treated with physical abrasion combined with a chemical peeling agent, compared to the skin in the control.
  
  
  CONCLUSIONS
  We concluded that physical dermabrasion combined with chemical peeling can be more effective than chemical peeling alone, for the approach through transfollicular routes.
authors.affiliation: Department of Dermatology, College of Medicine, Kyung Hee University , Seoul , Republic of Korea.
authors.forename: Boo Kyoung
authors.initials: BK
authors.lastname: Kang
authors.forename: Jeong Hwee
authors.initials: JH
authors.lastname: Choi
authors.forename: Ki Heon
authors.initials: KH
authors.lastname: Jeong
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Park
authors.forename: Dong Hye
authors.initials: DH
authors.lastname: Suh
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Shin
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D002452:Cell Count; D002615:Chemexfoliation; D003131:Combined Modality Therapy; D003869:Dermabrasion; D004815:Epidermal Growth Factor / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D005347:Fibroblasts / Q000737:chemistry; D008297:Male; D008407:Mast Cells; D009496:Neurotensin / Q000378:metabolism; D012060:Rejuvenation / Q000502:physiology*; D012867:Skin / Q000166:cytology* / Q000378:metabolism*; D012879:Skin Physiological Phenomena; D013552:Swine; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D009496:Neurotensin; D004815:Epidermal Growth Factor
keywords: chemical peeling; dermabrasion