title: ER - the key to the highway.
abstract: The endoplasmic reticulum (ER) is the key organelle at the start of the secretory pathway and the list of its functions is continually growing. The ER organization as a tubular/cisternal network at the cortex of plant cells has recently been shown to be governed by the membrane tubulation proteins of the reticulon family working alongside plant atlastin homologues, members of the RHD3 group of proteins. Such a network has intimate connections with other organelles such as peroxisomes via peroxules, chloroplasts, Golgi bodies and at the cell cortex to the plasma membrane with cytoskeleton at so called 'anchor/contact sites'. The ER network is by no means static displaying a range of different movements and acting as a subcellular highway supports the motility of organelles such as peroxisomes, mitochondria and Golgi bodies plus the transport of macromolecules such as viral movement proteins, nucleocapsid proteins and RNA. Here we highlight recent and exciting discoveries on the maintenance of the ER structure and its role on movement and biology of other organelles.
authors.affiliation: MSU-DOE Plant Research Lab, Michigan State University, East Lansing, MI 48824, United States; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, United States.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Stefano
authors.affiliation: Department of Biological and Medical Sciences, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
authors.forename: Chris
authors.initials: C
authors.lastname: Hawes
authors.affiliation: MSU-DOE Plant Research Lab, Michigan State University, East Lansing, MI 48824, United States; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, United States. Electronic address: fb@msu.edu.
authors.forename: Federica
authors.initials: F
authors.lastname: Brandizzi
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism; D020675:Peroxisomes / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism
chemical_list: D010940:Plant Proteins