title: Effects of short-term oral administration of trimethoprim-sulfamethoxazole on tear production in clinically normal Syrian hamsters.
abstract: OBJECTIVE
  To determine effects of 14 days of oral administration of trimethoprim-sulfamethoxazole on aqueous tear production in clinically normal Syrian hamsters.
  
  
  METHODS
  Fifteen healthy adult Syrian hamsters.
  
  
  METHODS
  Baseline phenol red thread test (PRTT) values were recorded 1 day prior to treatment. Eight hamsters in treated group received 15 mg/kg trimethoprim-sulfamethoxazole orally twice a day for 14 days. The remaining seven hamsters were used as untreated controls and received a placebo. All ophthalmic tests were performed without chemical restraint. PRTT values were evaluated in both eyes of all Syrian hamsters using a commercial PRTT strip of a single lot number.
  
  
  RESULTS
  The mean ± SD baseline PRTT values for treatment group and control group were 7.25 ± 1.3 mm/15 s and 5.42 ± 1.13 mm/15 s, respectively. After 14 days of drug administration, the mean ± SD PRTT values for treatment group and control group were 5.62 ± 1.5 and 5.64 ± 0.74, respectively. Significant decreases in the PRTT values, compared with baseline values, were observed in the treatment group on day 15 (P = 0.042).
  
  
  CONCLUSIONS
  Trimethoprim-sulfamethoxazole decreased tear production in the hamster in this study.
authors.affiliation: Department of Clinical Sciences, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Seyed Mehdi
authors.initials: SM
authors.lastname: Rajaei
authors.forename: Maneli
authors.initials: M
authors.lastname: Ansari Mood
authors.forename: Masoud
authors.initials: M
authors.lastname: Selk Ghaffari
authors.forename: Seyed Morteza
authors.initials: SM
authors.lastname: Razaghi Manesh
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008647:Mesocricetus; D013666:Tears / Q000187:drug effects* / Q000378:metabolism; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Syrian hamster; co-trimoxazole; phenol red thread test; tears production; trimethoprim-sulfamethoxazole