title: Activity of the investigational fluoroquinolone finafloxacin and seven other antimicrobial agents against 114 obligately anaerobic bacteria.
abstract: The activity of finafloxacin against 73 strains of the Bacteroides fragilis group, 10 other Gram-negative anaerobic rods and 31 Clostridium difficile strains was determined by the broth microdilution technique. The activity was compared with that of moxifloxacin, levofloxacin, ciprofloxacin, clindamycin, imipenem, piperacillin/tazobactam and metronidazole. MIC(50/90) values (minimum inhibitory concentration, in μg/mL, at which 50% and 90% of the isolates tested are inhibited, respectively) for finafloxacin for the different species were determined: B. fragilis group, 0.5/2; other Gram-negative rods, 0.06/0.25; and C. difficile, 4/16. Furthermore, the MICs against 11 selected B. fragilis strains were determined under acidic conditions and resulted in MIC(50/90) values for finafloxacin of 0.25/4 μg/mL. Thus, finafloxacin shows promising activity against several pathogenic species of anaerobes. Furthermore, finafloxacin has increased activity against selected B. fragilis strains under acidic conditions compared with activity at neutral pH.
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany. Electronic address: gelimergenzel@bundeswehr.org.
authors.forename: G H
authors.initials: GH
authors.lastname: Genzel
authors.affiliation: MerLion Pharmaceuticals GmbH, Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Stubbings
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany.
authors.forename: C S
authors.initials: CS
authors.lastname: Stîngu
authors.affiliation: MerLion Pharmaceuticals GmbH, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Labischinski
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Schaumann
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; C560572:finafloxacin
keywords: Anaerobic bacteria; Finafloxacin; Investigational fluoroquinolone