title: A case of foreign body granuloma induced by subcutaneous injection of leuprorelin acetate─clinical analysis for 335 cases in our hospital─.
abstract: We experienced a case of granuloma formation by subcutaneous injection of leuprorelin acetate for treatment of prostate cancer. This patient was an 80-year-old man visiting the clinic of gastroenterological surgery as an outpatient after gastric cancer surgery with a one-week's history of rash on the abdomen. Based on the history of gastric cancer and prostate cancer, though ultrasonography and CT were performed, the possibility of metastatic skin tumor could still not be ruled out. Finally, finding of a foreign-body granuloma in the subcutaneous adipose tissue was recognized histological. Then, an interview with the patient revealed that he had received subcutaneous injection of a 3-month depot formulation of leupurorelin acetate at the site of the lesion about two months earlier. Among urologists, as side effects for treatment, foreign body granuloma induced by subcutaneous injection of leuprorelin maybe well known. Therefore, it is tried to analyze as to clinical findings, especially granuloma formation for 335 cases that received leuprorelin acetate treatment at our hospital. In this report, we analyzed reported case and 335 cases that received leuprorelin acetate treatment at our hospital and summarized the cases that developed the granuloma formation by it.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan. kmayu@tokai-u.jp.
authors.forename: Mayu
authors.initials: M
authors.lastname: Kawai
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.forename: Azusa
authors.initials: A
authors.lastname: Yamada
authors.forename: Tami
authors.initials: T
authors.lastname: Ota
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Manabe
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kato
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Taro
authors.initials: T
authors.lastname: Higure
authors.forename: Toshiro
authors.initials: T
authors.lastname: Terachi
mesh_terms: D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000009:adverse effects*; D015745:Granuloma, Foreign-Body / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D016729:Leuprolide / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012867:Skin / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide