title: [Transdisciplinary Approach for Sarcopenia. The effects of exercise on skeletal muscle hypertrophy and satellite cells].
abstract: Skeletal muscle has a high degree of plasticity. The mass of skeletal muscle maintains owing to muscle protein synthesis and the regeneration by satellite cells. Skeletal muscle atrophy with aging (sarcopenia) is developed by decline of muscle protein synthesis and dysfunction of satellite cells. It is urgently necessary for today's highly aged society to elucidate the mechanism of sarcopenia and to establish prevention measure. This review shows that the positive effects of "exercise" on muscle protein synthesis and satellite cell function including their main molecular mechanism.
authors.affiliation: Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, Japan./Physical Education, Health and Sport Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan.
authors.forename: Shin
authors.initials: S
authors.lastname: Fujimaki
authors.forename: Tohru
authors.initials: T
authors.lastname: Takemasa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kuwabara
mesh_terms: D000375:Aging; D016923:Cell Death; D015444:Exercise; D006801:Humans; D009133:Muscular Atrophy / Q000378:metabolism / Q000628:therapy*; D055948:Sarcopenia / Q000628:therapy*; D027161:Satellite Cells, Perineuronal / Q000166:cytology / Q000378:metabolism; D015398:Signal Transduction