title: A novel screening test for colon cancer: Talin-1.
abstract: OBJECTIVE
  Cell adhesion and angiogenesis within the extracellular matrix involve special signaling molecules, such as integrins and the actin binding protein Talin-1. The aim of this study was to investigate and describe the expression of Talin-1 for the early detection of colon cancer.
  
  
  METHODS
  Blood serum samples were collected from 50 healthy volunteers and from 90 patients with colon cancer. Using an enzyme-linked immunosorbent assay (ELISA), all 140 samples were analyzed.
  
  
  RESULTS
  Preoperative levels of Talin-1 in the serum were significantly higher in patients with colon cancer (p < 0.001). No significant correlation was found between preoperative levels of Talin-1 in the serum and the age and gender of the patients (p < 0.05). However, a significant correlation was found between Talin-1 levels and the tumor grade, TNM stage, and lymph node metastasis (p < 0.001).
  
  
  CONCLUSIONS
  Talin-1 may play a role in the reinforcement of cell proliferation, cell adhesion, and angiogenesis in colon cancer. Thus, the Talin-1 protein activity may be a novel biomarker to detect colon cancer in humans.
authors.affiliation: General Surgery Clinic, Şişli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. ozgurkemik@hotmail.com.
authors.forename: O
authors.initials: O
authors.lastname: Bostanci
authors.forename: O
authors.initials: O
authors.lastname: Kemik
authors.forename: A
authors.initials: A
authors.lastname: Kemik
authors.forename: M
authors.initials: M
authors.lastname: Battal
authors.forename: U
authors.initials: U
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Purisa
authors.forename: M
authors.initials: M
authors.lastname: Mihmanli
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis / Q000097:blood; D002448:Cell Adhesion / Q000502:physiology; D003110:Colonic Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000473:pathology; D055088:Early Detection of Cancer / Q000379:methods; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016608:Talin / Q000096:biosynthesis / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; C518832:TLN1 protein, human; D016608:Talin