title: blaNDM-5 carried by an IncX3 plasmid in Escherichia coli sequence type 167.
abstract: bla(NDM-)5 was found in Escherichia coli strain 0215 from a Chinese patient without travel history. Genomic sequencing and conjugation experiments were performed. Strain 0215 belonged to sequence type 167 (ST167) and had other resistance determinants, including bla(TEM-135), bla(CTX-M-14), and aac(6')-Ib. bla(NDM-5) was carried by a 47-kb self-transmissible IncX3 plasmid and was in a complex genetic context similar to that of bla(NDM-1) on IncX3 plasmids. IncX3 plasmids might have emerged as a common vehicle mediating the spread of bla(NDM).
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.affiliation: Laboratory of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Feng
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China zongzhiy@scu.edu.cn.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zong
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D044466:Asian People; D003227:Conjugation, Genetic; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000254:growth & development; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000382:microbiology; D016680:Genome, Bacterial; D005838:Genotype; D006801:Humans; D008297:Male; D010957:Plasmids / Q000737:chemistry* / Q000378:metabolism; D017422:Sequence Analysis, DNA; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D001618:beta-Lactamases