title: Pilot Study of the Effect of Lanthanum Carbonate (Fosrenol®) In Patients with Calciphylaxis: A Wisconsin Network for Health Research (WiNHR) Study.
abstract: BACKGROUND
  Currently there is a lack of effective treatment options for patients with calciphylaxis. There is anecdotal evidence that non-calcium based phosphorus binders may offer some benefit. The aim of this pilot study is to determine if lanthanum carbonate is effective in inducing remission of calciphylaxis lesions and demonstrate an improved DLQI (Dermatology Life Quality Index).
  
  
  METHODS
  This is a multi-site exploratory pilot study conducted through the Wisconsin Network for Health Research (WiNHR), a collaboration of health services researchers across the state of Wisconsin. Dialysis patients were recruited from in-center dialysis units, clinics and hospital admissions over a period of 24-months.
  
  
  RESULTS
  Due to the low inclusion rate, the trial was terminated after which 4 patients were prospectively analyzed. Dose of lanthanum carbonate was escalated to 3750 mg divided into 3 meals and titrated according to level of serum phosphorus. Gastrointestinal symptoms were the most common adverse effect. All 4 patients achieved complete remission by definition of skin re-epithelialization. Secondary outcome measurements showed a significant improvement in serum albumin (B coeff 0.17, 95% CI 0.002-0.031; p=0.023) and a significant improvement in overall DLQI score (B coeff -0.46, 95% CI -0.85- -0.08; p=0.019).
  
  
  CONCLUSIONS
  Lanthanum carbonate appears to be efficacious as an adjunctive therapy to improve calciphylaxis lesions and symptom burden. More prospective clinical trials are warranted to determine the feasibility of this novel treatment strategy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Wisconsin School of Medicine and Public Health-Madison, USA.
authors.forename: Micah R
authors.initials: MR
authors.lastname: Chan
authors.affiliation: Division of Nephrology, Gundersen Health System, La Crosse, USA.
authors.forename: Fadi
authors.initials: F
authors.lastname: Ghandour
authors.affiliation: Division of Nephrology, Marshfield Clinic, Marshfield, USA.
authors.forename: Narayana S
authors.initials: NS
authors.lastname: Murali
authors.affiliation: Wisconsin Network for Health Research, University of Wisconsin School of Medicine and Public Health-Madison, USA.
authors.forename: Mj
authors.initials: M
authors.lastname: Washburn
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Wisconsin School of Medicine and Public Health-Madison, USA ; Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health-Madison, USA.
authors.forename: Brad C
authors.initials: BC
authors.lastname: Astor
keywords: Calcific uremic arteriolopathy; Calciphylaxis; Lanthanum