title: Coronary liposuction during percutaneous coronary intervention: evidence by near-infrared spectroscopy that aspiration reduces culprit lesion lipid content prior to stent placement.
abstract: OBJECTIVE
  Intracoronary near-infrared spectroscopy (NIRS) in ST-segment elevation myocardial infarction (STEMI) has demonstrated substantial lipid in STEMI culprit plaques. Thrombus aspiration during primary PCI reduces distal embolization and improves reperfusion. This study was performed to examine if aspiration thrombectomy reduces the lipid content of acute coronary syndrome (ACS) culprit plaques.
  
  
  RESULTS
  NIRS-IVUS imaging was performed in patients with an ACS at two hospitals in the US and Sweden. After establishment of TIMI 3 flow with an undersized balloon, NIRS was performed, followed by aspiration thrombectomy, followed by repeated NIRS. The same culprit segment was identified on the post-aspiration chemogram. The culprit lipid content was quantified before and after thrombectomy as the lipid core burden index (LCBI). Aspirates were examined by histological staining for lipids, calcium, and macrophages. In 18 ACS patients (age 65 ± 11, 61% male), culprit lesions were characterized by high lipid content prior to aspiration thrombectomy. Thrombectomy resulted in a 28% reduction in culprit lesion lipid content (pre-aspiration LCBI 466 ± 141 vs. post-aspiration 335 ± 117, P = 0.0001). In addition to thrombus, histological analysis of aspirates demonstrated the presence of lipids, calcium, and macrophages, indicating that fragments of atherosclerotic plaques had been aspirated.
  
  
  CONCLUSIONS
  Thrombectomy aspirates both thrombus and lipid-rich fragments of the culprit atherosclerotic plaques, thereby reducing material that may embolize during stenting. Reduction of lipid content before stenting might contribute to the beneficial effects of thrombectomy and may be particularly useful if a large lipid core is present at the culprit site.
authors.affiliation: Department of Cardiology, Lund University, 22185 Lund, Sweden david.erlinge@med.lu.se.
authors.forename: David
authors.initials: D
authors.lastname: Erlinge
authors.affiliation: Department of Cardiology, Lund University, 22185 Lund, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Harnek
authors.affiliation: Department of Cardiology, Lund University, 22185 Lund, Sweden Experimental Cardiovascular Research, Clinical Sciences, Lund University, Malmö, Sweden.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gonçalves
authors.affiliation: Department of Cardiology, Lund University, 22185 Lund, Sweden.
authors.forename: Matthias
authors.initials: M
authors.lastname: Götberg
authors.affiliation: Infraredx, Inc., Burlington, MA, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Muller
authors.affiliation: Frederik Meijer Heart & Vascular Institute, Spectrum Health, Grand Rapids, MI, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Madder
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015187:Lipectomy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D058226:Plaque, Atherosclerotic / Q000473:pathology* / Q000628:therapy; D011446:Prospective Studies; D018570:Risk Assessment; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D015607:Stents; D015996:Survival Rate; D017131:Thrombectomy / Q000379:methods; D016896:Treatment Outcome
keywords: Lipid-core plaque; Near-infrared spectroscopy; Thrombectomy