title: The effect of resveratrol on intimal hyperplasia and endothelial proliferation of rabbit carotid artery anastomosis.
abstract: OBJECTIVE
  We assessed the effect of resveratrol on intimal hyperplasia and endothelial proliferation after its use for carotid artery anastomosis in rabbits.
  
  
  METHODS
  Fourteen New Zealand-type male rabbits, weighing a mean of 2-3 kg were selected randomly. Their right carotid arteries were transected and anastomosed side by side using 8/0 polypropylene. The rabbits were divided into two groups with seven in each group. While the rabbits in the first group were accepted as the Control group, the rabbits in the second group were given resveratrol (1 mg/kg/day) for 14 days intravenously. At the end of the 28th day, all the carotid artery segments that were transected and anastomosed and the left carotid arteries that did not undergo surgery were removed and evaluated histologically.
  
  
  RESULTS
  The results of histological evaluation were as follows: lumen diameter (P <0.001) and lumen area (P <0.05) of the Resveratrol group were larger than those of the Control group, intimal thickness (P <0.05) and media thickness of the Resveratrol group (P = 0.04) were thinner than those of the Control group, and intima/media ratio of the Control group was found to be greater than that of the Resveratrol group (P = 0.002).
  
  
  CONCLUSIONS
  Resveratrol can prevent intimal hyperplasia and endothelial proliferation following surgical anastomosis.
authors.affiliation: Department of Cardiovascular Surgery, Izmir Tepecik Research and Education Hospital, Izmir, Turkey karaaslan4@hotmail.com.
authors.forename: Kemal
authors.initials: K
authors.lastname: Karaarslan
authors.affiliation: Department of Cardiovascular Surgery, Izmir Tepecik Research and Education Hospital, Izmir, Turkey.
authors.forename: Burcin
authors.initials: B
authors.lastname: Abud
authors.affiliation: Department of Cardiovascular Surgery, İzmir University Medical Park Hospital, Izmir, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Albayrak
authors.affiliation: Department of Cardiovascular Surgery, İzmir University Medical Park Hospital, Izmir, Turkey.
authors.forename: Koray
authors.initials: K
authors.lastname: Aykut
authors.affiliation: Department of Histology, Dokuz Eylül University Hospital, Izmir, Turkey.
authors.forename: Bekir Ugur
authors.initials: BU
authors.lastname: Ergür
authors.affiliation: Department of Cardiovascular Surgery, Dokuz Eylül University Hospital, Izmir, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Silistreli
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D059168:Carotid Intima-Media Thickness; D049109:Cell Proliferation / Q000187:drug effects*; D042783:Endothelial Cells / Q000187:drug effects* / Q000473:pathology; D006965:Hyperplasia; D008297:Male; D023421:Models, Animal; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D032389:Myocytes, Smooth Muscle / Q000187:drug effects* / Q000473:pathology; D058426:Neointima; D011817:Rabbits; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013267:Stilbenes; D000077185:Resveratrol
keywords: Endothelial proliferation; Intimal hyperplasia; Resveratrol