title: Antibodies to neurofascin exacerbate adoptive transfer experimental autoimmune neuritis.
abstract: Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy are autoimmune disorders of the peripheral nervous system in which autoantibodies are implicated in the disease pathogenesis. Recent work has focused on the nodal regions of the myelinated axon as potential autoantibody targets. Here we screened patient sera for autoantibodies to neurofascin and assessed the pathophysiological relevance of anti-neurofascin antibodies in vivo. Levels of anti-neurofascin antibodies were higher in sera from patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy when compared with those of controls. Anti-neurofascin antibodies exacerbated and prolonged adoptive transfer experimental autoimmune neuritis and caused conduction defects when injected intraneurally.
authors.affiliation: Neuroinflammation Group, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Weixing
authors.initials: W
authors.lastname: Yan
authors.affiliation: Neuroinflammation Group, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Toan
authors.initials: T
authors.lastname: Nguyen
authors.affiliation: Departments of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
authors.affiliation: Department of Neurology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Ji
authors.affiliation: Neuroinflammation Group, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: Con
authors.initials: C
authors.lastname: Yiannikas
authors.affiliation: Neuroinflammation Group, Brain & Mind Research Institute, University of Sydney, Sydney, Australia.
authors.forename: John D
authors.initials: JD
authors.lastname: Pollard
authors.affiliation: Neuroinflammation Group, Brain & Mind Research Institute, University of Sydney, Sydney, Australia. Electronic address: emily.mathey@sydney.edu.au.
authors.forename: Emily K
authors.initials: EK
authors.lastname: Mathey
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000276:immunology*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology; D020275:Guillain-Barre Syndrome / Q000097:blood*; D006801:Humans; D007116:Immunization, Passive / Q000009:adverse effects*; D008297:Male; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000633:toxicity; D009414:Nerve Growth Factors / Q000276:immunology*; D009431:Neural Conduction / Q000187:drug effects; D009444:Neuritis, Autoimmune, Experimental / Q000139:chemically induced* / Q000473:pathology; D025542:Neurofibromin 1 / Q000276:immunology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000187:drug effects / Q000503:physiopathology; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D015815:Cell Adhesion Molecules; D005732:Gangliosides; D063308:Myelin-Oligodendrocyte Glycoprotein; C054305:NFASC protein, human; D009414:Nerve Growth Factors; D025542:Neurofibromin 1
keywords: Autoantibody; Chronic inflammatory demyelinating polyneuropathy; Guillain–Barré syndrome; Neurofascin; Nodes of Ranvier