title: Expression of molecular biological markers in breast cancer under conditions of the Sakha Republic (Yakutia).
abstract: The results of histological studies of operation material from 294 women with breast cancer and immunohistochemical detection of estrogen and progesterone receptors and evaluation of proliferative activity (Ki-67) and expression of proteins p53 and bcl-2 were analyzed. Breast cancer was more incident (60%) in nonindigenous residents of the Sakha Republic (Yakutia) than in representatives of the indigenous population (40% cases). The disease was more incident in women aged 50-59 years (32.6%) and 60-69 years (21.8%) irrespective of the ethnic appurtenance. The findings indicated the most informative criteria of mammary tumor malignancy: low expression of estrogen and progesterone receptors, high expression of Ki-67 and p53, and low expression of bcl-2.
authors.affiliation: Yakut Research Center of Complex Medical Problems, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia, pathol@soramn.ru.
authors.forename: M P
authors.initials: MP
authors.lastname: Kirillina
authors.forename: K S
authors.initials: KS
authors.lastname: Loskutova
authors.forename: E L
authors.initials: EL
authors.lastname: Lushnikova
authors.forename: L M
authors.initials: LM
authors.lastname: Nepomnyashchikh
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism*; D017517:Commonwealth of Independent States; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016159:Tumor Suppressor Protein p53