title: Enhancer of zeste homolog 2 is widely expressed in T-cell neoplasms, is associated with high proliferation rate and correlates with MYC and pSTAT3 expression in a subset of cases.
abstract: Enhancer of zeste homolog 2 (EZH2), an epigenetic regulator and H3k27-specific histone methyltransferase, is important for transcriptional regulation. EZH2 has been found to be overexpressed in B-cell lymphomas, as well as some T-cell lymphomas. Here we investigated the expression of EZH2 by immunohistochemical staining in a wide range of T-cell neoplasms. We found that EZH2 is highly expressed in all categories of T-cell neoplasia studied, and its expression strongly correlates with a high proliferation rate. Although up-regulation of EZH2 has been reported to be modulated by the pSTAT3-MYC pathway, our data indicate that EZH2 expression is correlated with MYC and/or pSTAT3 expression in only a subset of T-cell lymphomas, and that other mechanisms may control the overexpression of EZH2 in many T-cell lymphomas. The high level of EZH2 expression in T cell lymphomas suggest that these neoplasms may benefit from targeted treatment with a small molecule inhibitor of EZH2 currently in use in clinical trials.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School , Boston, MA , USA.
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.forename: Ali
authors.initials: A
authors.lastname: Shahsafaei
authors.forename: Cuiling
authors.initials: C
authors.lastname: Liu
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yu
authors.forename: David M
authors.initials: DM
authors.lastname: Dorfman
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D049109:Cell Proliferation; D000071221:Enhancer of Zeste Homolog 2 Protein; D006801:Humans; D007124:Immunoenzyme Techniques; D015458:Leukemia, T-Cell / Q000378:metabolism / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology*; D009367:Neoplasm Staging; D010766:Phosphorylation; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism*; D011379:Prognosis; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2
keywords: EZH2; MYC; T-cell lymphoma; pSTAT3; proliferation