title: Effects of traditional Chinese medicine Fu Zheng decoction on the immunological function and clinical prognosis of the elderly patients with pneumonia.
abstract: Pneumonia is one of the most serious infectious diseases for elderly people who have impaired organ functions and are more susceptible to infection. Elderly patients having pneumonia often need long-term hospitalization, leading to declined quality of life, and increase of financial burden to the society and their family. Therefore, studies on novel therapeutic strategies and the clinical prognosis of the pneumonia patients are imperative. In the present study, we found that the Chinese herbal medicine Fu Zheng decoction had great immunomodulatory effects during the recovery period of elderly pneumonia patients. Patients treated with combined treatment of Fu Zheng decoction and antibiotic had a faster decline of temperature and a more significant decrease of C reactive protein and inflammatory factors level, and it is easier for them to cough off phlegm, compared with the antibiotic only treatment. Furthermore, the inflammation absorption and the reduction of NK-cell proportion as well as the inflammatory factors were more remarkable in the patients taken Fu Zheng decoction. Especially, the Fu Zheng decoction treatment could decrease the duration of antibiotic treatment, which may help reduce the side effects of antibiotics. Our study also found that MyD88 might play a role in the immunomodulatory effect of Fu Zheng decoction. Our study provides novel insight for the further development of intravenous injection of Chinese materia medica preparation on the regulation of immune function.
authors.affiliation: Department of Emergency Medicine, Shanghai East Hospital, Tong Ji University, Shanghai, 200120, China.
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Li
authors.forename: Shumin
authors.initials: S
authors.lastname: Xu
authors.forename: Tingting
authors.initials: T
authors.lastname: Cheng
authors.forename: Lunxian
authors.initials: L
authors.lastname: Tang
authors.forename: Jianwen
authors.initials: J
authors.lastname: Bai
authors.forename: Minjia
authors.initials: M
authors.lastname: Lin
mesh_terms: D000369:Aged, 80 and over; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008297:Male; D008516:Medicine, Chinese Traditional; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism; D011014:Pneumonia / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D011379:Prognosis; D011788:Quality of Life; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D053594:Myeloid Differentiation Factor 88