title: Myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs.
abstract: The aim of this study was to explore myocardial protection of early extracorporeal membrane oxygenation (ECMO) support for acute myocardial infarction with cardiogenic shock in pigs. 24 male pigs (34.6 ± 1.3 kg) were randomly divided into three groups-control group, drug therapy group, and ECMO group. Myocardial infarction model was created in drug therapy group and ECMO group by ligating coronary artery. When cardiogenic shock occurred, drugs were given in drug therapy group and ECMO began to work in ECMO group. The pigs were killed 24 h after cardiogenic shock. Compared with in drug therapy group, left ventricular end-diastolic pressure in ECMO group decreased significantly 6 h after ligation (P < 0.05). At the end of the experiments, LV - dp/dt among three groups was significantly different, drug therapy group < ECMO group < control group. There was no difference in LV + dp/dt between drug therapy group and ECMO group. Compared with drug group, myocardial infarct size of ECMO group did not reduce significantly, but myocardial enzyme and troponin-I decreased significantly. Compared with drug therapy, ECMO improves left ventricular diastolic function, and may improve systolic function. ECMO cannot reduce myocardial infarct size without revascularization, but may have positive effects on ischemic areas by avoiding further injuring.
authors.affiliation: Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China.
authors.forename: Gang-jie
authors.initials: GJ
authors.lastname: Zhu
authors.affiliation: Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China.
authors.forename: Li-na
authors.initials: LN
authors.lastname: Sun
authors.affiliation: Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China.
authors.forename: Xing-hai
authors.initials: XH
authors.lastname: Li
authors.affiliation: Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China. wangningfu@hotmail.com.
authors.forename: Ning-fu
authors.initials: NF
authors.lastname: Wang
authors.affiliation: Zhejiang University, Hangzhou City, China.
authors.forename: Hong-hai
authors.initials: HH
authors.lastname: Wu
authors.affiliation: Zhejiang University, Hangzhou City, China.
authors.forename: Chen-xing
authors.initials: CX
authors.lastname: Yuan
authors.affiliation: Zhejiang University, Hangzhou City, China.
authors.forename: Qiao-qiao
authors.initials: QQ
authors.lastname: Li
authors.affiliation: Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Xu
authors.affiliation: Department of Cardiovasology, Affiliated Hangzhou Hospital of Nanjing Medical University, No.261, Huansha Road, 310006, Hangzhou City, China.
authors.forename: Ya-qi
authors.initials: YQ
authors.lastname: Ren
authors.affiliation: Department of Cardiac Surgery, Affiliated Hangzhou Hospital of Nanjing Medical University, Hangzhou City, China.
authors.forename: Bao-gen
authors.initials: BG
authors.lastname: Mao
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005500:Follow-Up Studies; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D012770:Shock, Cardiogenic / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D013318:Stroke Volume / Q000502:physiology; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
keywords: Acute myocardial infarction; Cardiogenic shock; Extracorporeal membrane oxygenation (ECMO); Myocardial protection; Pigs