title: The role of AMPK in controlling metabolism and mitochondrial biogenesis during exercise.
abstract: Insulin resistance is associated with defects in skeletal muscle fatty acid (FA) metabolism that contribute to the development of type 2 diabetes. Endurance exercise increases FA and glucose metabolism, muscle mitochondrial content and insulin sensitivity. In skeletal muscle, basal rates of FA oxidation are dependent on AMP-activated protein kinase (AMPK) phosphorylation of acetyl-CoA carboxylase 2, the rate-limiting enzyme controlling the production of the metabolic intermediate malonyl-CoA. Likewise, AMPK is essential for maintaining muscle mitochondrial content in untrained mice; effects that may be mediated through regulation of the peroxisome proliferator-activated receptor γ co-activator-1α. However, the importance of AMPK in regulating glucose and FA uptake, FA oxidation and mitochondrial biogenesis during and following endurance exercise training is not fully understood. A better understanding of the mechanisms by which endurance exercise regulates substrate utilization and mitochondrial biogenesis may lead to improved therapeutic and preventative strategies for the treatment of insulin resistance and type 2 diabetes.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Katarina
authors.initials: K
authors.lastname: Marcinko
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada gsteinberg@mcmaster.ca.
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Steinberg
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008931:Mitochondria, Muscle / Q000378:metabolism*; D063269:Mitochondrial Turnover / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000263:Adenylate Kinase; D005947:Glucose