title: Hereditary Thrombophilic Factors in Glaucoma.
abstract: OBJECTIVE
  To evaluate the hereditary thrombophilic factors in patients with primary open-angle glaucoma, exfoliative glaucoma, and exfoliation syndrome and to compare their results with those of healthy control subjects.
  
  
  METHODS
  The study included 75 patients [25 patients with primary open-angle glaucoma (group I), 25 patients with exfoliative glaucoma (group II), and 25 patients with exfoliation syndrome (group III)] and 25 healthy control subjects (group IV). Well-known hereditary thrombophilic factors including methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation, prothrombin G20210A mutation, factor V Leiden mutation, activated protein C resistance, protein S, protein C, and antithrombin III activities, and homocysteine levels were measured in venous blood samples of all subjects.
  
  
  RESULTS
  Fifty-one males and 49 females were included in the study. The mean age of the patients was 67.8 ± 8.7 years (range, 46 to 87 y). There was no statistically significant difference with regard to the mean age (P=0.057) and distribution of sex (P=0.391) between the study groups. The difference of homocysteine, folate, vitamin B12, antithrombin III activity, protein C activity, free protein S activity, and activated protein C resistance were not statistically significant; and the number of subjects with MTHFR C677T, prothrombin G20210A, and factor V Leiden mutations were similar between the study groups.
  
  
  CONCLUSIONS
  Our results suggest that there is no significant difference between the prothrombotic inherited risk factors of glaucomatous and nonglaucomatous subjects.
authors.affiliation: *Ulucanlar Eye Training and Research Hospital †Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Sekeroglu
authors.forename: Murat
authors.initials: M
authors.lastname: Irkec
authors.forename: Mehmet C
authors.initials: MC
authors.lastname: Mocan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Orhan
mesh_terms: D020016:Activated Protein C Resistance / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000378:metabolism; D001779:Blood Coagulation Factors / Q000235:genetics / Q000378:metabolism*; D016022:Case-Control Studies; D017889:Exfoliation Syndrome / Q000097:blood* / Q000235:genetics; D005165:Factor V / Q000235:genetics / Q000378:metabolism; D005260:Female; D005902:Glaucoma, Open-Angle / Q000097:blood* / Q000235:genetics; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000097:blood / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011446:Prospective Studies; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011516:Prothrombin / Q000235:genetics / Q000378:metabolism; D012307:Risk Factors; D019851:Thrombophilia / Q000378:metabolism*
chemical_list: D001779:Blood Coagulation Factors; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D006710:Homocysteine; D000990:Antithrombin III; D005165:Factor V; D011516:Prothrombin; D042965:Methylenetetrahydrofolate Reductase (NADPH2)