title: Identification of a natural recombination in the F and H genes of feline morbillivirus.
abstract: Feline morbillivirus (FmoPV) has recently been identified in Hong Kong and Japan. FmoPV is considered to belong to the genus Morbillivirus, in the family Paramyxoviridae. In this study, the complete nucleotide sequences of three strains of FmoPV detected in cats in Japan were determined. Among the six genes in FmoPV; N, P/V/C, M, F, H and L, the P gene showed the highest polymorphism in the nucleotide and putative amino acid sequences among the FmoPV strains. There was no geographical association in terms of the FmoPV phylogeny; however, from extensive phylogenetic and recombination analyses, we found that one Japanese FmoPV strain, MiJP003, was a probable recombinant between two virus strains in the independent lineages found in Japan and Hong Kong, respectively. The recombination was considered to have occurred within the F and H genes. Such recombination is thought to be involved in the evolution of FmoPV.
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
authors.forename: Eun-Sil
authors.initials: ES
authors.lastname: Park
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Tokyo Metropolitan Animal Care and Consultation Center Jounanjima Branch Office, Tokyo 143-0002, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruyama
authors.affiliation: Tokyo Metropolitan Animal Care and Consultation Center Jounanjima Branch Office, Tokyo 143-0002, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizutani
authors.affiliation: Tokyo Metropolitan Animal Care and Consultation Center Jounanjima Branch Office, Tokyo 143-0002, Japan.
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Saito
authors.affiliation: Tokyo Metropolitan Animal Care and Consultation Center Jounanjima Branch Office, Tokyo 143-0002, Japan.
authors.forename: Nami
authors.initials: N
authors.lastname: Kubota
authors.affiliation: Research and education center for prevention of global infectious diseases of animals, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Furuya
authors.affiliation: Research and education center for prevention of global infectious diseases of animals, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizutani
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Imaoka
authors.affiliation: Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo 162-8640, Japan. Electronic address: morikawa@nih.go.jp.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Morikawa
mesh_terms: D000818:Animals; D001483:Base Sequence; D002371:Cat Diseases / Q000453:epidemiology / Q000821:virology*; D002415:Cats; D015967:Gene Expression Regulation, Viral / Q000502:physiology; D006723:Hong Kong / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D018103:Morbillivirus / Q000235:genetics*; D018185:Morbillivirus Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011110:Polymorphism, Genetic; D016865:Reassortant Viruses; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D014764:Viral Proteins
keywords: Feline morbillivirus; Fusion protein; Hemagglutinin protein; Recombination