title: Microbial transformation of 20(S)-protopanaxatriol by Mucor spinosus.
abstract: Microbial transformation of 20(S)-protopanaxatriol (1) by Mucor spinosus afforded two new and eight known metabolites. The structures of the metabolites were identified as 12-oxo-20(S)-protopanaxatriol (2), 23,24-en-25-methoxyl-20(S)-protopanaxatriol (3), 29-hydroxyl-20(S)-protopanaxatriol (4), 20(S),24(S)-epoxy-dammaran-3β,6α,12β,25-triol (5), 12-oxo-27-hydroxyl-20(S)-protopanaxatriol (6), 12-oxo-26-hydroxyl-20(S)-protopanaxatriol (7), 12-oxo-23β-hydroxyl-20(S)-protopanaxatriol (8), 12-oxo-11β-hydroxyl-20(S)-protopanaxatriol (9), 12-oxo-15α-hydroxyl-20(S)-protopanaxatriol (10), and 12-oxo-25,26-en-15α-hydroxyl-20(S)-protopanaxatriol (11). Among them, 3 and 11 are new compounds. The metabolites 3, 10 and 11 showed the more potent inhibitory effects against seven cell lines than the substrate.
authors.affiliation: School of Pharmacy, Nantong University, Nantong, 226001, People's Republic of China, yang_xue_2008@126.com.
authors.forename: Xue
authors.initials: X
authors.lastname: Yang
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Ge
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Jianlin
authors.initials: J
authors.lastname: Li
authors.forename: Guangtong
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D001711:Biotransformation; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D006801:Humans; D009089:Mucor / Q000378:metabolism*; D012502:Sapogenins / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology*; D014709:Vero Cells
chemical_list: D012502:Sapogenins; C081552:protopanaxatriol