title: Recombinant lactic acid bacteria as delivery vectors of heterologous antigens: the future of vaccination?
abstract: Lactic acid bacteria (LABs) are good candidates for the development of new oral vaccines and are attractive alternatives to attenuated pathogens. This review focuses on the use of wild-type and recombinant lactococci and lactobacilli with emphasis on their molecular design, immunomodulation and treatment of bacterial infections. The majority of studies related to recombinant LABs have focused on Lactococcus lactis, however, molecular tools have been successfully used for Lactobacillus spp.
  
  
  METHODS
  Recombinant lactobacilli and lactococci have several health benefits, such as immunomodulation, restoration of the microbiota, synthesis of antimicrobial substances and inhibition of virulence factors. In addition, protective immune responses that are well tolerated are induced by the expression of heterologous antigens from recombinant probiotics.
authors.affiliation: Center for Genomics and Bioinformatics, Faculty of Science, Universidad Mayor, Camino La Piramide 5750, Huechuraba, Santiago, Chile.
authors.forename: A
authors.initials: A
authors.lastname: Trombert
mesh_terms: D000818:Animals; D015478:Antigens, Heterophile / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D005822:Genetic Vectors / Q000235:genetics* / Q000276:immunology; D006801:Humans; D056546:Lactobacillales / Q000235:genetics* / Q000378:metabolism; D014611:Vaccination / Q000379:methods* / Q000639:trends
chemical_list: D015478:Antigens, Heterophile
keywords: heterologous expression; oral vaccine; probiotic; recombinants probiotics; vaccine delivery