title: The potential beneficial role of faecal microbiota transplantation in diseases other than Clostridium difficile infection.
abstract: This review gives an outline of the indications for faecal microbiota transplantation (FMT) for diseases other than Clostridium difficile (C. difficile) infection. The remarkable efficacy of FMT against C. difficile infection has already been demonstrated. The use of FMT for other diseases, such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and metabolic syndrome, is now being evaluated. The currently available data suggest that FMT might be beneficial for IBD (including ulcerative colitis and, to some extent, Crohn's disease), IBS, and insulin resistance. Several randomized clinical trials are currently being performed, and data are eagerly awaited. A new field of research for the implementation of FMT is the eradication of pathogenic and multiresistant enteric microorganisms. A few animal studies have been performed within this field, but hardly any research data from human studies are available at present.
authors.affiliation: Renal Transplant Unit, Division of Nephrology, Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Nieuwdorp
authors.forename: I J M
authors.initials: IJ
authors.lastname: ten Berge
authors.forename: F J
authors.initials: FJ
authors.lastname: Bemelman
authors.forename: S E
authors.initials: SE
authors.lastname: Geerlings
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D005243:Feces; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000628:therapy*; D043183:Irritable Bowel Syndrome / Q000628:therapy*; D024821:Metabolic Syndrome / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic
keywords: Faecal microbiota transplantation; inflammatory bowel disease; irritable bowel syndrome; multiresistant microorganisms; obesity; type 2 diabetes