title: Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer.
abstract: Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.
authors.affiliation: Department of Medicine, College of Physicians and Surgeons,1.
authors.forename: Kevin
authors.initials: K
authors.lastname: Kalinsky
authors.forename: Emerson A
authors.initials: EA
authors.lastname: Lim
authors.forename: Eleni
authors.initials: E
authors.lastname: Andreopoulou
authors.forename: Avni M
authors.initials: AM
authors.lastname: Desai
authors.forename: Zhezhen
authors.initials: Z
authors.lastname: Jin
authors.forename: Yifan
authors.initials: Y
authors.lastname: Tu
authors.forename: Hanina
authors.initials: H
authors.lastname: Hibshoosh
authors.forename: Antai
authors.initials: A
authors.lastname: Wang
authors.forename: Heather
authors.initials: H
authors.lastname: Greenlee
authors.forename: Katherine D
authors.initials: KD
authors.lastname: Crew
authors.forename: Matthew
authors.initials: M
authors.lastname: Maurer
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Sparano
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Hershman
mesh_terms: D064096:Aurora Kinase A / Q000235:genetics; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics; D049109:Cell Proliferation; D056744:Cyclin B1 / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics; D019394:Ki-67 Antigen / Q000235:genetics; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009518:New York; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D000077022:Survivin; D015534:Trans-Activators / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: D064096:Aurora Kinase A; D018797:Cell Cycle Proteins; D056744:Cyclin B1; D051034:Inhibitor of Apoptosis Proteins; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D000077022:Survivin; D015534:Trans-Activators; C107489:BIRC5 protein, human; C534699:CCNB1 protein, human; C064352:MYBL2 protein, human
keywords: Breast cancer; Hispanic; Non-Hispanic white; Oncotype DX; Proliferation axis score; Tumor proliferation