title: [Effect of compound Danshen dripping pills combined with atorvastatin on restenosis after angioplasty in rabbits].
abstract: OBJECTIVE
  To study the effect of compound Danshen dripping pills and atorvastatin on restenosis after abdominal aorta angioplasty in rabbits.
  
  
  METHODS
  Rabbit models of abdominal aorta restenosis after angioplasty were established and treated with saline (group A), compound Danshen dripping pills (group B), atorvastatin (group C), or compound Danshen dripping pills plus atorvastatin (group D). HE staining was used to determine the thickness of arterial intimal hyperplasia and assess the morphological changes of the narrowed artery. Immunohistochemistry was employed to detect the expression of nuclear factor-κB (NF-κB) and monocyte chemoattractant protein-1 (MCP-1).
  
  
  RESULTS
  Compared with group A, the 3 treatment groups showed significant increased vascular cavity area and reduced intimal area and percentage of intimal hyperplasia (P<0.05). The vascular cavity area, intimal area and percentage of intimal hyperplasia levels differed significantly between group D and groups B and C (P<0.05). Immunohistochemistry showed a significant reduction of the expression rate of NF-κB and MCP-1 in the 3 treatment groups compared with group A (P<0.05), and the reduction was especially obvious in group D (P<0.05).
  
  
  CONCLUSIONS
  Compound danshen dripping pills combined with atorvastatin produces better effects than the drugs used alone in inhibiting vascular smooth muscle cell proliferation in rabbits after abdominal aorta angioplasty possibly due to a decreased expression of MCP-1 as a result of NF-κB inhibition.
authors.affiliation: Department of Cardiology of The Fifth Affiliated Hospital of Southern Medical, Guangzhou 510900 China. E-mail: mf-422@163.com.
authors.forename: Jieli
authors.initials: J
authors.lastname: Song
authors.forename: Jinpei
authors.initials: J
authors.lastname: Zeng
authors.forename: Yongxia
authors.initials: Y
authors.lastname: Zhang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Lihong
authors.initials: L
authors.lastname: Zhang
authors.forename: Cibin
authors.initials: C
authors.lastname: Chen
mesh_terms: D017130:Angioplasty; D000818:Animals; D001011:Aorta / Q000473:pathology*; D000069059:Atorvastatin; D049109:Cell Proliferation; D018932:Chemokine CCL2 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006538:Heptanoic Acids / Q000494:pharmacology*; D006965:Hyperplasia; D032389:Myocytes, Smooth Muscle / Q000187:drug effects; D016328:NF-kappa B / Q000378:metabolism; D010618:Phenanthrolines; D011758:Pyrroles / Q000494:pharmacology*; D011817:Rabbits; D027561:Salvia miltiorrhiza / Q000737:chemistry; D017539:Tunica Intima
chemical_list: D018932:Chemokine CCL2; D004365:Drugs, Chinese Herbal; D006538:Heptanoic Acids; D016328:NF-kappa B; D010618:Phenanthrolines; D011758:Pyrroles; C028972:dan-shen root extract; D000069059:Atorvastatin