title: Systems Biology and immune aging.
abstract: Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a given biological system. Systems Biology benefits from the continuous advances in the omics sciences, based on high-throughput and high-content technologies, as well as on bioinformatic tools for data mining and integration. The Systems Biology approach is becoming gradually used to propose and to test comprehensive models of aging, both at the level of the immune system and the whole organism. In this way, immune aging may be described by a dynamic view of the states and interactions of every individual cell and molecule of the immune system and their role in the context of aging and longevity. This mini-review presents a panoramics of the current strategies, tools and challenges for applying Systems Biology to immune aging.
authors.affiliation: Laboratory of Translational Cytomics, Joint Research Unit, University of Valencia and Principe Felipe Research Center, Valencia, Spain. Electronic address: jose.e.oconnor@uv.es.
authors.forename: José-Enrique
authors.initials: JE
authors.lastname: O'Connor
authors.affiliation: Laboratory of Cytometry, Incliva Foundation, Clinical University Hospital, University of Valencia, Valencia, Spain.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Herrera
authors.affiliation: Cytometry Technological Service, Principe Felipe Research Center, Valencia, Spain.
authors.forename: Alicia
authors.initials: A
authors.lastname: Martínez-Romero
authors.affiliation: Laboratory of Translational Cytomics, Joint Research Unit, University of Valencia and Principe Felipe Research Center, Valencia, Spain.
authors.forename: Francisco Sala
authors.initials: FS
authors.lastname: de Oyanguren
authors.affiliation: Laboratory of Translational Cytomics, Joint Research Unit, University of Valencia and Principe Felipe Research Center, Valencia, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Díaz
authors.affiliation: Laboratory of Translational Cytomics, Joint Research Unit, University of Valencia and Principe Felipe Research Center, Valencia, Spain.
authors.forename: Angela
authors.initials: A
authors.lastname: Gomes
authors.affiliation: Laboratory of Translational Cytomics, Joint Research Unit, University of Valencia and Principe Felipe Research Center, Valencia, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Balaguer
authors.affiliation: Department of Pathology, Faculty of Medicine, The University of Valencia, Valencia, Spain.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Callaghan
mesh_terms: D000375:Aging / Q000276:immunology*; D006801:Humans; D007109:Immunity / Q000502:physiology*; D049490:Systems Biology / Q000379:methods*
keywords: Bioinformatics; Cytomics; Genomics; Longevity; Metabolomics; Proteomics