title: Undifferentiated uterine carcinoma: analysis of eighteen cases.
abstract: Analysis of the surgicopathological characteristics and clinical follow-up of patients with undifferentiated uterine carcinoma (UUC) was conducted. A total of 18 cases operated between January 1993 and December 2013 were included. Among 1,690 patients with endometrial cancer, 18 patients (1.1%) had UUC. Lymph node involvement was detected in 70.6%; depth of myometrial invasion was ≥ 0.5 in 55.6%; lymphovascular space invasion was detected in 99.3%; cervical stromal invasion was positive in 27.8%; omental and adnexal involvement were detected in 11.8% and 38.9%, respectively. The median follow-up time of the 12 patients evaluated in the survival analysis was 66 months. In the follow-up period, recurrence or progression during adjuvant therapy were observed in four patients (33.3%) and two patients (16.6%) died of the disease. UUC manifests as an aggressive tumour. In conclusion, a high rate of survival could be achieved with complete staging surgery, including an extensive lymphadenectomy with the contribution of adjuvant therapy.
authors.affiliation: Gynecologic Oncology Division, Etlik Zubeyde Hanim Women's Health Teaching and Research Hospital , Ankara , Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Üreyen
authors.forename: H
authors.initials: H
authors.lastname: Ilgin
authors.forename: T
authors.initials: T
authors.lastname: Turan
authors.forename: T
authors.initials: T
authors.lastname: Taşçi
authors.forename: A
authors.initials: A
authors.lastname: Karalök
authors.forename: N
authors.initials: N
authors.lastname: Boran
authors.forename: A
authors.initials: A
authors.lastname: Özfuttu
authors.forename: G
authors.initials: G
authors.lastname: Tulunay
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D059186:Chemoradiotherapy, Adjuvant / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy / Q000379:methods / Q000706:statistics & numerical data; D008197:Lymph Node Excision / Q000379:methods / Q000706:statistics & numerical data; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016019:Survival Analysis; D014421:Turkey / Q000453:epidemiology; D014599:Uterus / Q000473:pathology*
keywords: Endometrial cancer; surgicopathological factors; survival; undifferentiated tumour