title: Use of lactoferrin in the newborn: where do we stand?
abstract: Sepsis and necrotizing enterocolitis (NEC) cause significant morbidity and mortality in the newborn. Their ill effects persist in spite of appropriate and effective antibiotic therapy. Lactoferrin as an adjunct to antibiotics in the treatment of sepsis or NEC in the newborn may improve the clinical outcomes by enhancing the host defense and modulating the inflammatory response. This review focuses on the various aspects of lactoferrin use in the newborn.
authors.affiliation: a Department of Neonatology , Fernandez Hospital , Hyderguda , Hyderabad , Andhra Pradesh , India and.
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.forename: Anuradha
authors.initials: A
authors.lastname: Murki
authors.forename: Srinivas
authors.initials: S
authors.lastname: Murki
authors.forename: Oleti Tejo
authors.initials: OT
authors.lastname: Pratap
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002657:Child Development / Q000187:drug effects; D020345:Enterocolitis, Necrotizing / Q000188:drug therapy; D005325:Fetal Organ Maturity / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000276:immunology; D007781:Lactoferrin / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D007155:Immunologic Factors; D007781:Lactoferrin
keywords: Anti-bacterial; anti-fungal; anti-viral; fungal sepsis; immunomodulation; lactoferrin; necrotizing enterocolitis; neonatal sepsis