title: The use of polymeric microcarriers loaded with anti-inflammatory substances in the therapy of experimental skin wounds.
abstract: We studied the effects of anti-inflammatory substances incorporated in polymeric microparticles made of degradable natural polyhydroxyalkanoate polyesters on experimental skin wounds caused by chemical burns in laboratory animals. Treatment with encapsulated forms of anti-inflammatory substances (applied in gel) accelerated wound healing in comparison with routine therapy (estimated by area of burn wound, wound healing activity, number of acanthotic cells, and number of hair and sebaceous follicles). The results showed the perspectives of usage of developed form of substances (degradable polymeric microparticles) for treatment of skin defects.
authors.affiliation: Institute of Biophysics, Siberian Division of Russian Academy of Sciences, Krasnoyarsk, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Murueva
authors.forename: A M
authors.initials: AM
authors.lastname: Shershneva
authors.forename: E I
authors.initials: EI
authors.lastname: Shishatskaya
authors.forename: T G
authors.initials: TG
authors.lastname: Volova
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D051379:Mice; D008807:Mice, Inbred BALB C; D011108:Polymers / Q000737:chemistry*; D012867:Skin / Q000293:injuries*; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D011108:Polymers