title: [Clinical significance of peripheral blood CD4+CD25+ regulatory T cell in patients with extranodal NK/T cell lymphoma, nasal type].
abstract: OBJECTIVE
  To investigate the clinical significance of peripheral blood regulatory T cell (Treg) population in patients with extranodal NK/T cell lymphoma, nasal type (ENKL).
  
  
  METHODS
  The peripheral blood CD4+CD25+ Treg cell population was detected by flow cytometry in 41 newly diagnosed ENKL patients between March 2009 and December 2012.
  
  
  RESULTS
  The proportion of CD4+CD25+ Treg cell population increased in ENKL patients compared to healthy donors [(9.64±4.96)% vs(7.31±3.02)%, P<0.05], and decreased significantly after treatment [(5.18±2.19)%, P<0.01]. Patients when got response had significantly lower proportion of Treg cells [(8.79±4.15)%] as compared with those without response [(14.57±6.73)%, P<0.05]. The proportion of Treg population was positively related to the serum lactate dehydrogenass level.
  
  
  CONCLUSIONS
  The proportion of peripheral blood Treg cells may be helpful for predicting prognosis and therapeutic efficacy in ENKL patients.
authors.affiliation: Department of Hematology, Beijing Tongren Hospital Affilited to Capital Medical University, Beijing 100730, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Hematology, Beijing Tongren Hospital Affilited to Capital Medical University, Beijing 100730, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, Beijing Tongren Hospital Affilited to Capital Medical University, Beijing 100730, China.
authors.forename: Xueying
authors.initials: X
authors.lastname: Cui
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes; D005434:Flow Cytometry; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000276:immunology*; D011379:Prognosis
chemical_list: C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit