title: BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib.
authors.affiliation: Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.
authors.forename: Marco
authors.initials: M
authors.lastname: Ranzani
authors.forename: Constantine
authors.initials: C
authors.lastname: Alifrangis
authors.forename: Daniele
authors.initials: D
authors.lastname: Perna
authors.forename: Ken
authors.initials: K
authors.lastname: Dutton-Regester
authors.forename: Antonia
authors.initials: A
authors.lastname: Pritchard
authors.forename: Kim
authors.initials: K
authors.lastname: Wong
authors.forename: Mamunur
authors.initials: M
authors.lastname: Rashid
authors.forename: Carla Daniela
authors.initials: CD
authors.lastname: Robles-Espinoza
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Hayward
authors.forename: Ultan
authors.initials: U
authors.lastname: McDermott
authors.forename: Mathew
authors.initials: M
authors.lastname: Garnett
authors.forename: David J
authors.initials: DJ
authors.lastname: Adams
mesh_terms: D045744:Cell Line, Tumor; D004252:DNA Mutational Analysis; D004354:Drug Screening Assays, Antitumor; D020558:GTP Phosphohydrolases / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000235:genetics; D008565:Membrane Proteins / Q000378:metabolism*; D009154:Mutation / Q000235:genetics*; D025542:Neurofibromin 1 / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*; D011728:Pyridones / Q000494:pharmacology / Q000627:therapeutic use*; D011744:Pyrimidinones / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D008565:Membrane Proteins; D025542:Neurofibromin 1; D011728:Pyridones; D011744:Pyrimidinones; C560077:trametinib; D048493:Proto-Oncogene Proteins B-raf; D020558:GTP Phosphohydrolases; C579846:NRAS protein, human