title: Adverse neurologic effects of medications commonly used in the intensive care unit.
abstract: Adverse drug effects often complicate the care of critically ill patients. Therefore, each patient's medical history, maintenance medication, and new therapies administered in the intensive care unit must be evaluated to prevent unwanted neurologic adverse effects. Optimization of pharmacotherapy in critically ill patients can be achieved by considering the need to reinitiate home medications, and avoiding drugs that can decrease the seizure threshold, increase sedation and cognitive deficits, induce delirium, increase intracranial pressure, or induce fever. Avoiding medication-induced neurologic adverse effects is essential in critically ill patients, especially those with neurologic injury.
authors.affiliation: Department of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, 1225 Center Drive, HPNP Building, Room 3315, PO Box 100486, Gainesville, FL 32610-0486, USA.
authors.forename: Stacy A
authors.initials: SA
authors.lastname: Voils
authors.affiliation: Barnes-Jewish Hospital, Washington University in St. Louis, St. Louis, MO 63110, USA.
authors.forename: Theresa
authors.initials: T
authors.lastname: Human
authors.affiliation: Departments of Pharmacotherapy & Outcomes Science and Neurosurgery, Medical College of Virginia Campus, Virginia Commonwealth University, 410 North, 12th Street, Richmond, VA 23298-0533, USA. Electronic address: gbrophy@vcu.edu.
authors.forename: Gretchen M
authors.initials: GM
authors.lastname: Brophy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000009:adverse effects*; D002317:Cardiovascular Agents / Q000009:adverse effects*; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D055815:Young Adult
chemical_list: D000700:Analgesics; D002317:Cardiovascular Agents; D006993:Hypnotics and Sedatives
keywords: Adverse effects; Critical care; Drug interactions; Neurocritical care; Neurologic complications