title: Increase in the serum parathyroid hormone level during a bisphosphonate drug holiday.
abstract: After discontinuation of bisphosphonate therapy, an antiresorptive effect and antifracture protection persist for an undefined period. Patients are encouraged to continue calcium and vitamin D supplementation, during a bisphosphonate drug holiday. However, assessment of adequate calcium intake during the bisphosphonate drug holiday is difficult. Therefore, we measured the serum intact parathyroid hormone (PTH) level as a surrogate marker. A premenopausal woman discontinued bisphosphonate therapy, after 7.5 years of treatment. Two months later, blood calcium and phosphorus levels were normal, serum 25-hydroxyvitamin D level was 31.3 ng/mL, but serum PTH level had increased to 94.9 pg/mL. The elemental calcium supplement dose was increased to 600 mg/day, with no change in the cholecalciferol dose (400 IU). Her serum PTH levels decreased to 49.1 after 4 months and 32.9 pg/mL after 5 months. The serum PTH level may be helpful in assessing adequate calcium intake during a bisphosphonate drug holiday.
authors.affiliation: Department of Internal Medicine, Nowon Eulji Hospital, Seoul, Korea.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, Nowon Eulji Hospital, Seoul, Korea.
authors.forename: Jeong Min
authors.initials: JM
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Nowon Eulji Hospital, Seoul, Korea.
authors.forename: Sun Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Eulji University Hospital, Daejeon, Korea. ; Department of Biochemistry-Molecular Biology, School of Medicine, Eulji University, Daejeon, Korea.
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Lee
keywords: Bisphosphonate; Calcium; Parathyroid hormone; Vitamin D