title: New advances in the mesenchymal stem cells therapy against skin flaps necrosis.
abstract: Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.
authors.affiliation: Fu-Gui Zhang, Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Fu-Gui
authors.initials: FG
authors.lastname: Zhang
authors.affiliation: Fu-Gui Zhang, Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Xiu-Fa
authors.initials: XF
authors.lastname: Tang
keywords: Endothelial progenitor cells; Mesenchymal stem cells; Skin flaps