title: Research on antioxidant activity of EOB-F and its function in the diagnosis of heart and cerebral vessels.
abstract: This paper introduces the research progress related to the antioxidant activity of bamboo leaf flavonoid (EOB-f) and its pharmacological activity of heart and cerebral vessels. The paper studied what role EOB-f played in the diagnosis of heart and cerebral vessels, based on the in vitro, in vivo and animal model as well as the pharmacological research experiment. 1) The in vitro and in vivo experiments indicated that EOB-f has the function of anti-reactive-oxide species, anti-aging and anti-fatigue; 2) The research of animal model indicated that EOB-f can significantly decrease the triglyceride (TG) content in serum, significantly increase high density lipoprotein cholesterol (HDL-C) content in serum, regulate blood lipids and reduce the risk of atherosclerosis; 3) The pharmacological study showed that EOB-f has the effect to resist the whole animal anoxia, can effectively dilate coronary vessels, increase coronary flow, increase myocardial contractility, obviously improve myocardial ischemia and diminish the myocardial infarction scope, inhibit the coagulation process and reduce platelet aggregation, and has certain protective effect on cerebral ischemia. EOB-f has the potential to develop as the natural drug and functional foods for prevention of cardiovascular and cerebrovascular diseases.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Zhengbin
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Zhanying
authors.initials: Z
authors.lastname: Han
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Chunguang Qiu
authors.initials: CQ
authors.lastname: Qiu
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Zhenwen
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Guoju
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Wenjie
authors.initials: W
authors.lastname: Lu
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Qin
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002561:Cerebrovascular Disorders / Q000188:drug therapy*; D008076:Cholesterol, HDL / Q000097:blood; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D031787:Sasa
chemical_list: D000975:Antioxidants; D008076:Cholesterol, HDL; D005419:Flavonoids