title: The relationship between Helicobacter pylori and beta-2 microglobulin in humans.
abstract: H. pylori is related to various gastrointestinal diseases. β₂ Microglobulin (β 2M) is an intrinsic element of major histocompatibility complex (MHC I). Serum β₂M level may increase in inflammatory states. The aim of current study is to evaluate the relationship between β₂M and H. pylori bearing CagA strains.
  
  
  METHODS
  H. pylori status was determined by histopathology of samples taken from stomach. CagA status and β₂M level were measured from blood samples of patients. Eradication therapy was administered to the patients with H. pylori infection. β₂ Microglobulin levels were measured before and after treatment.
  
  
  RESULTS
  35 (29.2%) H. pylori(-) patients and 85 (70.8%) H. pylori (+) patients were included in the study. There were 52 (43.3%) patients with CagA negative and 33 (27.5%) patients with CagA positive H. pylori infection. The mean serum β₂M level was 1.83 mg/L in H. pylori (-) group, 1.76 mg/L in H. pylori (+) CagA (-) group, and 1.93 mg/L in H. pylori and CagA (+) group (P > 0.05). Serum β 2M levels (1.82 versus 1.64 mg/L P < 0.05) were decreased after eradication.
  
  
  CONCLUSIONS
  H. pylori and CagA status did not affect β₂M level. Relationship between low grade systematic inflammation and H. pylori should be investigated to find out new predictors for diseases associated with inflammation.
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Abdullah Özgür
authors.initials: AÖ
authors.lastname: Yeniova
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kucukazman
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.affiliation: Department of Internal Medicine, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Kursat
authors.initials: K
authors.lastname: Dal
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kefeli
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Sebahat
authors.initials: S
authors.lastname: Başyiğit
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Bora
authors.initials: B
authors.lastname: Aktaş
authors.affiliation: Department of Clinical Biochemistry, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Kadir Okhan
authors.initials: KO
authors.lastname: Akın
authors.affiliation: Department of Gastroenterology, Kecioren Teaching and Research Hospital, Kecioren, 06380 Ankara, Turkey.
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Nazlıgül
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D001613:beta 2-Microglobulin