title: Impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.
abstract: OBJECTIVE
  To investigate the impact of blood type, functional polymorphism (T-1676C) of the COX-1 gene promoter, and clinical factors on the development of peptic ulcer during cardiovascular prophylaxis with low-dose aspirin.
  
  
  METHODS
  In a case-control study including 111 low-dose aspirin users with peptic ulcers and 109 controls (asymptomatic aspirin users), the polymorphism (T-1676C) of the COX-1 gene promoter was genotyped, and blood type, H pylori status, and clinical factors were assessed.
  
  
  RESULTS
  Univariate analysis showed no significant differences in genotype frequencies of the COX-1 gene at position -1676 between the peptic ulcer group and control group. Multivariate analysis revealed that blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID were the independent risk factors for the development of peptic ulcer with the odds ratios of the 2.1, 3.1, 27.6, and 2.9, respectively.
  
  
  CONCLUSIONS
  The C-1676T polymorphism in the COX-1 gene promoter is not a risk factor for ulcer formation during treatment with low-dose aspirin. Blood type O, advanced age, history of peptic ulcer, and concomitant use of NSAID are of independent significance in predicting peptic ulcer development during treatment with low-dose aspirin.
authors.affiliation: Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors.forename: Pin-Yao
authors.initials: PY
authors.lastname: Wang
authors.affiliation: Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors.forename: Hsiu-Ping
authors.initials: HP
authors.lastname: Chen
authors.affiliation: Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors.forename: Angela
authors.initials: A
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Feng-Woei
authors.initials: FW
authors.lastname: Tsay
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Kwok-Hung
authors.identifier: 0000-0002-3085-6534
authors.initials: KH
authors.lastname: Lai
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Sung-Shuo
authors.initials: SS
authors.lastname: Kao
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Department of Chemistry, College of Science, National Kaohsiung Normal University, Kaohsiung 802, Taiwan.
authors.forename: Wen-Chi
authors.identifier: 0000-0002-7572-4201
authors.initials: WC
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
authors.forename: Chao-Hung
authors.identifier: 0000-0002-6027-8296
authors.initials: CH
authors.lastname: Kuo
authors.affiliation: School of Medicine, National Yang-Ming University, Taipei 112, Taiwan ; Department of Nuclear Medicine, Kaohsiung Veterans General Hospital and National Yang-Ming University, Kaohsiung 813, Taiwan.
authors.forename: Nan-Jing
authors.initials: NJ
authors.lastname: Peng
authors.affiliation: Department of Pathology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan.
authors.forename: Hui-Hwa
authors.initials: HH
authors.lastname: Tseng
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, 386 Ta Chung 1st Road, Kaohsiung 813, Taiwan ; School of Medicine, National Yang-Ming University, Taipei 112, Taiwan.
authors.forename: Ping-I
authors.initials: PI
authors.lastname: Hsu
mesh_terms: D000017:ABO Blood-Group System / Q000502:physiology*; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects* / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control; D016022:Case-Control Studies; D051545:Cyclooxygenase 1 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000139:chemically induced / Q000453:epidemiology* / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System; D051545:Cyclooxygenase 1; C496511:PTGS1 protein, human; D001241:Aspirin