title: The shape of D-glucosamine.
abstract: The bioactive amino monosaccharide D-glucosamine has been generated in the gas phase via laser ablation of D-glucosamine hydrochloride. Three cyclic α-(4)C1 pyranose forms have been identified using Fourier transform microwave techniques. Stereoelectronic hyperconjugative forces - essentially linked with the anomeric or gauche effect - and cooperative OH···O, OH···N and NH···O chains, extended along the entire molecule, are found to be the main factors driving the conformational behavior. The orientation of the NH2 group within each conformer has been determined by the values of the nuclear quadrupole coupling constants. The results have been compared with those recently obtained for the archetypical D-glucose.
authors.affiliation: Grupo de Espectroscopía Molecular (GEM), Unidad Asociada CSIC, Edificio Quifima, Laboratorios de Espectroscopia y Bioespectroscopia, Parque Científico UVa, Universidad de Valladolid, 47011 Valladolid, Spain. jlalonso@qf.uva.es.
authors.forename: Isabel
authors.initials: I
authors.lastname: Peña
authors.forename: Lucie
authors.initials: L
authors.lastname: Kolesniková
authors.forename: Carlos
authors.initials: C
authors.lastname: Cabezas
authors.forename: Celina
authors.initials: C
authors.lastname: Bermúdez
authors.forename: Matías
authors.initials: M
authors.lastname: Berdakin
authors.forename: Alcides
authors.initials: A
authors.lastname: Simão
authors.forename: José L
authors.initials: JL
authors.lastname: Alonso
mesh_terms: D002236:Carbohydrate Conformation; D005944:Glucosamine / Q000737:chemistry*; D008872:Microwaves; D013237:Stereoisomerism
chemical_list: D005944:Glucosamine