title: Streptococcus pneumoniae Genome Database (SPGDB): a database for strain specific comparative analysis of Streptococcus pneumoniae genes and proteins.
abstract: Streptococcus pneumoniae causes pneumonia, septicemia and meningitis. S. pneumoniae is responsible for significant mortality both in children and in the elderly. In recent years, the whole genome sequencing of various S. pneumoniae strains have increased manifold and there is an urgent need to provide organism specific annotations to the scientific community. This prompted us to develop the Streptococcus pneumoniae Genome Database (SPGDB) to integrate and analyze the completely sequenced and available S. pneumoniae genome sequences. Further, links to several tools are provided to compare the pool of gene and protein sequences, and proteins structure across different strains of S. pneumoniae. SPGDB aids in the analysis of phenotypic variations as well as to perform extensive genomics and evolutionary studies with reference to S. pneumoniae. The database will be updated at regular intervals and is freely accessible through the URL: http://pranag.physics.iisc.ernet.in/SPGDB/.
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.
authors.forename: Rayapadi G
authors.initials: RG
authors.lastname: Swetha
authors.affiliation: Laboratory for Structural Biology and Biocomputing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Dinesh Kumar Kala
authors.initials: DK
authors.lastname: Sekar
authors.affiliation: Laboratory for Structural Biology and Biocomputing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Ekambaram Durga
authors.initials: ED
authors.lastname: Devi
authors.affiliation: Laboratory for Structural Biology and Biocomputing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Zaheer Zameer
authors.initials: ZZ
authors.lastname: Ahmed
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Ramaiah
authors.affiliation: Medical & Biological Computing Laboratory, School of Biosciences and Technology, VIT University, Vellore 632 014, India. Electronic address: aanand@vit.ac.in.
authors.forename: Anand
authors.initials: A
authors.lastname: Anbarasu
authors.affiliation: Laboratory for Structural Biology and Biocomputing, Supercomputer Education and Research Centre, Indian Institute of Science, Bangalore 560 012, India.
authors.forename: Kanagaraj
authors.initials: K
authors.lastname: Sekar
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D030541:Databases, Genetic; D005798:Genes, Bacterial; D008969:Molecular Sequence Data; D011487:Protein Conformation; D017422:Sequence Analysis, DNA / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D013296:Streptococcus pneumoniae / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins
keywords: Annotation; Database; Genome; Pneumococci; Resistance