title: Protracted fecal shedding of HEV during ribavirin therapy predicts treatment relapse.
abstract: Twenty-four solid-organ-transplant recipients with chronic hepatitis E virus (HEV) infections were given ribavirin therapy for 3 months. All the patients with protracted fecal HEV shedding during treatment suffered a relapse. Monitoring HEV fecal excretion could be used to determine the optimal duration of ribavirin therapy.
authors.affiliation: INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut fédératif de biologie de Purpan.
authors.forename: Florence
authors.initials: F
authors.lastname: Abravanel
authors.affiliation: INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut fédératif de biologie de Purpan.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lhomme
authors.affiliation: INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CHU Toulouse, Hôpital Rangueil, Service de Néphrologie, Dialyse et Transplantation multi-organe, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.affiliation: INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CHU Toulouse, Hôpital Rangueil, Service de Néphrologie, Dialyse et Transplantation multi-organe, France.
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.affiliation: INSERM, U1043, Centre de Physiopathologie de Toulouse Purpan CHU Toulouse, Hôpital Purpan, Laboratoire de virologie, Centre National de Référence Hépatite E, Institut fédératif de biologie de Purpan.
authors.forename: Jacques
authors.initials: J
authors.lastname: Izopet
mesh_terms: D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D005243:Feces / Q000821:virology*; D005260:Female; D016751:Hepatitis E / Q000188:drug therapy* / Q000821:virology*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation; D012008:Recurrence; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome; D017201:Virus Shedding
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin
keywords: fecal shedding; hepatitis E virus; relapse; ribavirin therapy