title: Leptomeningeal failure of retinoblastoma.
abstract: Leptomeningeal (LM) failure of retinoblastoma (Rb) has not previously been reported. Upon review of our institutional experience of external beam radiotherapy (EBRT) for Rb, we found three LM failures. We sought to better define the clinical parameters of this type of recurrence. All children with LM failure had Reese-Ellsworth stage Vb eyes. Otherwise, no variables were significantly associated with LM failure. We theorize that this phenomenon is a function of the late-stage eyes for which EBRT is being reserved in the modern era.
authors.affiliation: Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Amber
authors.initials: A
authors.lastname: Orman
authors.forename: Arnold
authors.initials: A
authors.lastname: Markoe
authors.forename: Peter A S
authors.initials: PA
authors.lastname: Johnstone
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D009367:Neoplasm Staging; D061766:Proton Therapy; D012175:Retinoblastoma / Q000473:pathology* / Q000532:radiotherapy*
keywords: leptomeningeal disease; pediatric malignancy; retinoblastoma