title: Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males.
abstract: OBJECTIVE
  To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery.
  
  
  METHODS
  The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 2009. Ten healthy, white European males visited the laboratory twice, on separate mornings. On each visit, the volunteers consumed water (3 ml/kg bodyweight) and rested semi-supine on the bed. After 30 minutes, baseline diastolic brachial artery diameter and blood velocity was measured. At 60 minutes, blood velocity and five scans of brachial artery diameter were recorded before a blood pressure cuff was inflated on the forearm for 5 minutes and at 50-60-70-80 and 90 sec after cuff deflation. Fifteen minutes later, the volunteers consumed 500 ml of test-drink containing either fructose (0.75 g/kg bodyweight) or sucralose (sweetness-matched with fructose drink); 45 minutes later, baseline and flow-mediated dilatation was re-measured.
  
  
  RESULTS
  Pre-drink and post-drink baseline values were similar on two occasions (p > 0.05). Brachial artery diameter increased (p < 0.05) by 7 +/- 3% pre-fructose and by 6.9 +/- 3% above baseline values post-fructose with no significant difference in these responses (p < 0.15). It increased (p < 0.05) by 5.9 +/- 3% above baseline before and by 6.7 +/- 2% (p < 0.01) after sucralose; a significant difference was noted in these flow-mediated dilatation responses (p < 0.02). Responses before and after sucralose were not different from those before and after fructose (p < 0.294).
  
  
  CONCLUSIONS
  Acute ingestion of fructose or sucralose had no effect on flow-mediated dilatation measured at brachial artery.
authors.forename: Muhammad Qasim
authors.initials: MQ
authors.lastname: Memon
authors.forename: Elizabeth Jane
authors.initials: EJ
authors.lastname: Simpson
authors.forename: Ian Andrew
authors.initials: IA
authors.lastname: Macdonald
mesh_terms: D001916:Brachial Artery / Q000187:drug effects / Q000502:physiology*; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D005632:Fructose / Q000494:pharmacology*; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects*; D044465:White People
chemical_list: D013549:Sweetening Agents; D005632:Fructose; D013395:Sucrose; C026285:trichlorosucrose