title: [Elution properties of linezolid bone cement].
abstract: OBJECTIVE
  To explore the elution properties of linezolid bone cement so as to guide the clinical application of linezolid bone cement in the treatment of infection after total joint arthroplasty.
  
  
  METHODS
  The specimens of bone cement (40 g each) were divided into 6 groups depending on mixed different contents with linezolid (5 specimens in each group), group I (1.2 g), group II (2.4 g), group III (3.6 g), group IV (4.8 g), group V (6.0 g) and group VI (7.2 g). The time-dependent elution of linezolid from bone cement was measured by high performance liquid chromatography (HPLC).
  
  
  RESULTS
  The release rate of linezolid bone cement samples was positively correlated with the concentration of antibiotics. And he release rate increased with the rising concentrations. The release of all groups dropped dramatically at Day 1. And as of Day 2 there was a slow release at a very low level. The elution of all groups persisted through 7 weeks. The analysis of variance between groups showed significant differences in release rates. And further examination by q test revealed that the release of group of 3.6-7.2 g was significantly higher than other groups.
  
  
  CONCLUSIONS
  The drainage tube should be clamped at Day 1 post-operation so that there is a full release of high concentration of linezolid. Adding 3.6 g linezolid to 40 g cement may provide better cost-effective outcomes.
authors.affiliation: Department of Orthopedics, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Changjiao
authors.initials: C
authors.lastname: Sun
authors.forename: Wei
authors.initials: W
authors.lastname: Chai
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Email: zhouyg@263.net.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001843:Bone Cements; D006801:Humans; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001843:Bone Cements; D023303:Oxazolidinones; D000069349:Linezolid