title: Differential expression of periostin in the nasal polyp may represent distinct histological features of chronic rhinosinusitis.
abstract: OBJECTIVE
  Chronic rhinosinusitis (CRS) is thought to be a multifactorial disease, and it is classified into a number of subtypes according to clinicohistological features. Periostin, a 90-kDa secreted protein, was reported to exist in nasal polyps (NPs) associated with CRS. We compared the expression of periostin with the degree of eosinophilic infiltration as well as tissue remodeling.
  
  
  METHODS
  Tissue samples were collected from 28 patients of CRS with NPs, and clinicohistological features were evaluated. The pattern of periostin expression was assessed immunohistochemically.
  
  
  RESULTS
  Two patterns of periostin expression was observed in nasal polyps: "diffuse type", in which periostin was expressed throughout the lamina propria starting just below the basement membrane, and "superficial type", in which the protein was detected only in the subepithelial layers between the basement membrane and the nasal gland. The average infiltrated eosinophil count in the diffuse type was significantly higher than that in the superficial type (diffuse type 360.5±393.0 vs. superficial type 8.46±13.81, p=0.001). Tissue remodeling was observed in 17 (85.0%) of the 20 diffuse-type nasal polyps, but only in one (12.5%) of the eight superficial-type nasal polyps (p<0.001).
  
  
  CONCLUSIONS
  At least two distinct patterns of periostin expression were observed in the nasal polyps associated with CRS in accordance with the heterogeneous mechanisms underlying the pathogenesis of CRS with NPs.
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan; Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan. Electronic address: oshiono@yokohama-cu.ac.jp.
authors.forename: Osamu
authors.initials: O
authors.lastname: Shiono
authors.affiliation: Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sakuma
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Komatsu
authors.affiliation: Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Hirama
authors.affiliation: Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Yamashita
authors.affiliation: Department of Otorhinolaryngology, and Head and Neck Surgery, Yokohama City University Medical Center, Yokohama, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Ishitoya
authors.affiliation: Department of Otorhinolaryngology and Head and Neck Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Oridate
mesh_terms: D001485:Basement Membrane / Q000378:metabolism; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002452:Cell Count; D002908:Chronic Disease; D015331:Cohort Studies; D004804:Eosinophils / Q000166:cytology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000166:cytology / Q000378:metabolism; D009298:Nasal Polyps / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D012189:Retrospective Studies; D012220:Rhinitis / Q000145:classification / Q000378:metabolism* / Q000473:pathology; D012852:Sinusitis / Q000145:classification / Q000378:metabolism* / Q000473:pathology
chemical_list: D015815:Cell Adhesion Molecules; C512835:POSTN protein, human
keywords: Chronic rhinosinusitis; Nasal polyp; Periostin; Remodeling