title: Risk Assessment of BRONJ in Oncologic Patients Treated with Bisphosphonates: Follow-Up to 18 Months.
abstract: Objectives. Bisphosphonates related osteonecrosis of the jaw (BRONJ) is a pathological condition characterized by bone exposure or latent infection in patients treated with the drug. The aim of the study is to monitor the BRONJ level of risk health in patients with cancer, according to a preventive clinical protocol, which is firstly aimed at reducing risk factors such as the periodontal infections. Materials and Methods. 10 patients participated in the protocol and were evaluated at baseline and after 3 and 18 months of treatment with bisphosphonates, through full mouth plaque and bleeding scores (FMPS and FMBS), clinical attachment level (CAL) measurement, and the occurrence of osteonecrosis. Results. The mean plaque and bleeding were reduced and the CAL has not shown significant changes and in no cases was there manifestation of BRONJ. Conclusion. The protocol proved crucial for the maintenance of good oral health conditions by eliminating the risk of BRONJ during the observation period.
authors.affiliation: Department of Clinical Sciences and Stomatology, Faculty of Medicine, Polytechnic University of Marche, Palace "Murri", Floor No. 3, Via Tronto 10, 60126 Ancona, Italy.
authors.forename: Scilla
authors.identifier: 0000-0003-0353-1184
authors.initials: S
authors.lastname: Sparabombe
authors.affiliation: Department of Clinical Sciences and Stomatology, Faculty of Medicine, Polytechnic University of Marche, Palace "Murri", Floor No. 3, Via Tronto 10, 60126 Ancona, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Vitali
authors.affiliation: Special and Surgical Stomatology Department, "Ospedali Riuniti" Hospital of Ancona, Via Conca 2, 60126 Ancona, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Nori
authors.affiliation: Special and Surgical Stomatology Department, "Ospedali Riuniti" Hospital of Ancona, Via Conca 2, 60126 Ancona, Italy.
authors.forename: Ricarda Sara
authors.initials: RS
authors.lastname: Berlin
authors.affiliation: Stomatology and Maxillofacial Science Department, University of Rome "La Sapienza", Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Mazur
authors.affiliation: Department of Clinical Sciences and Stomatology, Faculty of Medicine, Polytechnic University of Marche, Palace "Murri", Floor No. 3, Via Tronto 10, 60126 Ancona, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Orsini
authors.affiliation: Department of Clinical Sciences and Stomatology, Faculty of Medicine, Polytechnic University of Marche, Palace "Murri", Floor No. 3, Via Tronto 10, 60126 Ancona, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Putignano