title: Protective immunity of a modified-live cyprinid herpesvirus 3 vaccine in koi (Cyprinus carpio koi) 13 months after vaccination.
abstract: OBJECTIVE
  To evaluate the long-term protective immunity of a cyprinid herpesvirus 3 (CyHV3) vaccine in naïve koi (Cyprinus carpio koi).
  
  
  METHODS
  72 koi. Procedures-Vaccinated koi (n = 36) and unvaccinated control koi (36) were challenge exposed to a wild-type CyHV3 strain (KHVp8 F98-50) 13 months after vaccination.
  
  
  RESULTS
  The CyHV3 vaccine provided substantial protective immunity against challenge exposure. The proportional mortality rate was less in vaccinated koi (13/36 [36%]) than in unvaccinated koi (36/36 [100%]). For koi that died during the experiment, mean survival time was significantly greater in vaccinated than in unvaccinated fish (17 vs 10 days).
  
  
  CONCLUSIONS
  The CyHV3 vaccine provided substantial protective immunity against challenge exposure with CyHV3 13 months after vaccination. This provided evidence that koi can be vaccinated annually with the CyHV3 vaccine to significantly reduce mortality and morbidity rates associated with CyHV3 infection.
authors.affiliation: Departments of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: O'Connor
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Farver
authors.forename: Kirsten V
authors.initials: KV
authors.lastname: Malm
authors.forename: Susan C
authors.initials: SC
authors.lastname: Yun
authors.forename: Gary D
authors.initials: GD
authors.lastname: Marty
authors.forename: Kira
authors.initials: K
authors.lastname: Salonius
authors.forename: Arnon
authors.initials: A
authors.lastname: Dishon
authors.forename: E P Scott
authors.initials: EP
authors.lastname: Weber
mesh_terms: D000818:Animals; D002347:Carps; D005393:Fish Diseases / Q000517:prevention & control* / Q000821:virology; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines