title: Effect of lithium on HIV-1 expression and proviral reservoir size in the CD4+ T cells of antiretroviral therapy suppressed patients.
abstract: Previous in-vitro data pointed out lithium, an activator of the β-catenin signalling pathway, as a modulator of HIV-1 transcription. We assessed the effect of in-vivo administration of lithium on viral latency modulation in nine antiretroviral therapy (ART)-suppressed HIV-1-infected individuals. We found that lithium carbonate treatment was able to transiently repress HIV-1 residual expression in CD4 T cells in vivo, which led to a concomitant short-term decrease in the proviral reservoir size.
authors.affiliation: aAIDS Research Institute - IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona b'Lluita Contra la Sida' Foundation, Hospital Universitari Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona cUniversitat de Vic - Universitat Central de Catalunya (UVic-UCC) dCatalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Puertas
authors.forename: Maria
authors.initials: M
authors.lastname: Salgado
authors.forename: Sara
authors.initials: S
authors.lastname: Morón-López
authors.forename: Dan
authors.initials: D
authors.lastname: Ouchi
authors.forename: Jose A
authors.initials: JA
authors.lastname: Muñoz-Moreno
authors.forename: José
authors.initials: J
authors.lastname: Moltó
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
authors.forename: Javier
authors.initials: J
authors.lastname: Martinez-Picado
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D004279:DNA, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D008042:Linolenic Acids / Q000494:pharmacology*; D018020:Lithium Compounds / Q000494:pharmacology*; D011533:Proviruses / Q000235:genetics; D015398:Signal Transduction; D019562:Viral Load / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects / Q000276:immunology; D014779:Virus Replication; D051176:beta Catenin / Q000235:genetics / Q000276:immunology
chemical_list: D019380:Anti-HIV Agents; D004279:DNA, Viral; D008042:Linolenic Acids; D018020:Lithium Compounds; D051176:beta Catenin