title: [Expression of the HIF-2α in epithelial ovarian cancer and clinical significance].
abstract: OBJECTIVE
  To investigate the expression of hypoxia inducible factor 2α (HIF-2α) in every clinical stage and the pathological grade of epithelial ovarian cancer, and to discuss the role of HIF-2α in carcinogenesis, progression and outcomes of epithelial ovarian tumors.
  
  
  METHODS
  Protein expression of HIF-2α in epithelial ovarian tissue from 77 randomly selected specimens was detected by SP immunohistochemistry staining. The relation between the expression of HIF-2α and prognosis of 40 patients with epithelial ovarian cancer was analyzed by Cox regression model.
  
  
  RESULTS
  There was positive relation between the positivity rates of HIF-2α and malignant grade, FIGO stage, histological grade and invasive metastasis. The live time of the patients with HIF-2α positive expression was shorter than those with negative expression.
  
  
  CONCLUSIONS
  HIF-2α may play an important role in the genesis, development, invasion and metastasis of ovarian cancer and it may possess the vital clinical significance for prognosis evaluation.
authors.affiliation: Department of Obstetrics and Gynecology, Second Xiangya Hospital, Changsha 410011, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Kuan
authors.initials: K
authors.lastname: Peng
authors.forename: Ling
authors.initials: L
authors.lastname: He
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D000077216:Carcinoma, Ovarian Epithelial; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D011379:Prognosis; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1