title: Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction.
abstract: The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration.
authors.affiliation: Discipline of Pathophisiology, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 - Cerqueira César, 1° andar, sala 1353, 01246903, São Paulo, SP, Brazil.
authors.forename: Camila
authors.initials: C
authors.lastname: Nascimento
authors.forename: Helena Kyunghee
authors.initials: HK
authors.lastname: Kim
authors.forename: L Trevor
authors.initials: LT
authors.lastname: Young
authors.forename: Karina Martinez
authors.initials: KM
authors.lastname: Mendonça
authors.forename: Lea Tenenholz
authors.initials: LT
authors.lastname: Grinberg
authors.forename: Beny
authors.initials: B
authors.lastname: Lafer
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Andreazza
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors*; D005978:Glutathione / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D018020:Lithium Compounds / Q000494:pharmacology*; D009447:Neuroblastoma / Q000378:metabolism; D050050:Protein Carbonylation / Q000187:drug effects*; D012402:Rotenone / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D018020:Lithium Compounds; D014475:Uncoupling Agents; D012402:Rotenone; C002744:3-nitrotyrosine; D014443:Tyrosine; D042967:Electron Transport Complex I; D005978:Glutathione