title: [Microsurgical removal and prognostic analysis of petroclival meningiomas].
abstract: OBJECTIVE
  To identify factors that predictive of quality of life after microsurgical removal of petroclival meningiomas.
  
  
  METHODS
  A consecutive series of 71 cases of petroclival meningiomas received microsurgical removal between July 1991 and April 2010 were analyzed retrospectively. Quality of life was measured using Karnofsky performance scale (KPS). Complete pre-operative, post-operative and follow-up data were obtained from all 71 patients including 18 male and 53 female patients with the mean age of (47 ± 11) years (aging from 15 to 68 years). The duration between onset of symptoms and diagnosis ranged from 1 week to 180 months with the mean duration of (32 ± 30) months. And the tumor size was 15-72 mm with the average of (44 ± 11) mm. Main presentations included headache, unsteady gait, hemiparesis, dysphagia, hoarseness, facial numbness or pain, Bell's palsy, hearing impairment etc. The preoperative KPS was 40-100 with the average of 69 ± 11. The retrosigmoid (-transtentorial) approach was performed in most cases (91.5%). Intergroup χ² test and logistic regression analysis were conducted for prognostic factor characterization.
  
  
  RESULTS
  The gross total resection (all were Simpson gradeII) reached in 48 cases (67.6%) and 1 case died postoperatively. The main new neurological dysfunctions were cranial nerve paralysis and hemiplegia with the postoperative KPS of 20-100 with the average of 73 ± 16.Sixty-four cases were followed for 4-132 months with the average of (61 ± 48) months. Seven patients died during follow-up, tumor recurrence and progression were identified in 6 and 8 cases, respectively. The KPS at the last visit ranged from 50 to 100 with the average of 83 ± 13. The extent of tumor resection (OR = 0.280, 95% CI: 0.081-0.967, P = 0.044), preoperative brainstem edema (OR = 0.100, 95% CI: 0.027-0.372, P = 0.001), relationships between tumor and neurovascular structures (OR = 0.288, 95% CI: 0.084-0.985, P = 0.047) and depth of invasion into cavernous sinus (OR = 0.254, 95% CI: 0.061-1.057, P = 0.048) had significant correlations with the prognostic quality of life.
  
  
  CONCLUSIONS
  With regard of the choice of surgical approaches, the extent of tumor resection, the protection of neurovascular structures surrounding the tumor and the management of perioperative period, the therapeutic strategies for each patient should be customized to achieve better prognosis.
authors.affiliation: Department of Neurosurgery, Xiangya Hospital, Central South University; Neurosurgical Institute, Central South University; the Institute of Skull Base Surgery and Neuroncology at Hunan, Changsha 410008, China.
authors.forename: Zijin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Xianrui
authors.initials: X
authors.lastname: Yuan
authors.forename: Huayuan
authors.initials: H
authors.lastname: Zou
authors.forename: Weixi
authors.initials: W
authors.lastname: Jiang
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Liao
authors.forename: Duanwu
authors.initials: D
authors.lastname: Luo
authors.forename: Zefeng
authors.initials: Z
authors.lastname: Peng
authors.forename: Xuejun
authors.initials: X
authors.lastname: Li
authors.forename: Dingyang
authors.initials: D
authors.lastname: Liu
authors.affiliation: Email: chingliucn@yahoo.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000601:surgery*; D008866:Microsurgery; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult