title: Two birds with one stone: dendrimer surface engineering enables tunable periphery hydrophobicity and rapid endosomal escape.
abstract: Multifunctional thermosensitive dendrimeric nanocarriers were generated via tailored surface modification. Such design not only facilitated the rapid endosomal escape of dendrimers, but also achieved tunable surface hydrophobicity, which could be employed to achieve on-demand cargo release. These smart dendrimers are promising for enhancing intracellular drug delivery.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, School of Pharmaceutical Science & Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China. zhaoyj@tju.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Ruihong
authors.initials: R
authors.lastname: Liu
authors.forename: Aiping
authors.initials: A
authors.lastname: Fan
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D057005:Bioengineering; D002470:Cell Survival / Q000187:drug effects; D050091:Dendrimers / Q000737:chemistry* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems; D011992:Endosomes / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D061986:MCF-7 Cells; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013696:Temperature
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; C531249:Poly(amidoamine); D011073:Polyamines