title: Research on recovery function of two drugs combination on rat sciatic nerve injury regeneration model.
abstract: This paper aims to study the recovery function of two drugs combination on rat sciatic nerve injury regeneration model. Sixty rats were divided into groups randomly and averagely. All animals after dividing left sciatic nerve were given epineurium-interrupted suture for constructing peripheral nerve injury model. Muscle on operation side in medication administration team was injected 0.5 ml drug while the contract group was given equal amount of normal saline. Sciatic nerve function evaluation and nerve electrophysiology index detection were conducted after operation at fixed period. We drew materials for morphological observation 12 weeks after operation. The results showed that group with independent administration of nerve growth factor (NGF) and nimodipine (ND) in large dose was superior than group in small dose in nerve electro physiology index (P<0.05) and group with combination administration of NGF and ND in large dose was also superior than group in small dose (P<0.05). In addition, regeneration effect of combination administration group was better than that of independent administration group when using same dose. The larger the dose was, the better the effect was. We can conclude that two-drug combination can promote recovery function on rat sciatic nerve injury regeneration model.
authors.affiliation: Department of Orthopaedics, Yishui Central Hospital, Linyi, Shandong, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ju
authors.affiliation: Department of Orthopaedics, Yishui Central Hospital, Linyi, Shandong, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department Radiology, Jinan Central Hospital, Shandong Province, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics, Xiangyang Central Hospital, Hubei Province, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zheng
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008297:Male; D020932:Nerve Growth Factor / Q000008:administration & dosage*; D009416:Nerve Regeneration / Q000187:drug effects*; D009553:Nimodipine / Q000008:administration & dosage*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology
chemical_list: D009553:Nimodipine; D020932:Nerve Growth Factor