title: Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study.
abstract: Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth in polycystic kidney disease. Whether AVP also affects kidney structure in the general population is unknown. We analyzed the association of copeptin, an established surrogate for AVP, with parameters of renal function and morphology in a multicentric population-based cohort. Participants from families of European ancestry were randomly selected in three Swiss cities. We used linear multilevel regression analysis to explore the association of copeptin with renal function parameters as well as kidney length and the presence of simple renal cysts assessed by ultrasound examination. Copeptin levels were log-transformed. The 529 women and 481 men had median copeptin levels of 3.0 and 5.2 pmol/L, respectively (P<0.001). In multivariable analyses, the copeptin level was associated inversely with eGFR (β=-2.1; 95% confidence interval [95% CI], -3.3 to -0.8; P=0.002) and kidney length (β=-1.2; 95% CI, -1.9 to -0.4; P=0.003) but positively with 24-hour urinary albumin excretion (β=0.11; 95% CI, 0.01 to 0.20; P=0.03) and urine osmolality (β=0.08; 95% CI, 0.05 to 0.10; P<0.001). A positive association was found between the copeptin level and the presence of renal cysts (odds ratio, 1.6; 95% CI, 1.1 to 2.4; P=0.02). These results suggest that AVP has a pleiotropic role in renal function and may favor the development of simple renal cysts.
authors.affiliation: Divisions of Nephrology and Institute of Social and Preventive Medicine and.
authors.forename: Belen
authors.initials: B
authors.lastname: Ponte
authors.affiliation: Division of Nephrology, University Hospital of Lausanne, Lausanne, Switzerland;
authors.forename: Menno
authors.initials: M
authors.lastname: Pruijm
authors.affiliation: Department of Nephrology, Hypertension, and Clinical Pharmacology, University Hospital, University of Bern, Bern, Switzerland; and.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ackermann
authors.affiliation: Institute of Social and Preventive Medicine and.
authors.forename: Philippe
authors.initials: P
authors.lastname: Vuistiner
authors.affiliation: Institute of Social and Preventive Medicine and Units of Populational Epidemiology and Department of Community Medicine and Primary Care, University Hospital of Geneva, Geneva, Switzerland;
authors.forename: Idris
authors.initials: I
authors.lastname: Guessous
authors.affiliation: Cardiology.
authors.forename: Georg
authors.initials: G
authors.lastname: Ehret
authors.affiliation: Institute of Social and Preventive Medicine and.
authors.forename: Heba
authors.initials: H
authors.lastname: Alwan
authors.affiliation: Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Sonia
authors.initials: S
authors.lastname: Youhanna
authors.affiliation: Institute of Social and Preventive Medicine and.
authors.forename: Fred
authors.initials: F
authors.lastname: Paccaud
authors.affiliation: Department of Nephrology, Hypertension, and Clinical Pharmacology, University Hospital, University of Bern, Bern, Switzerland; and.
authors.forename: Markus
authors.initials: M
authors.lastname: Mohaupt
authors.affiliation: Department of Community Medicine and Primary Care, University Hospital of Geneva, Geneva, Switzerland; Hypertension.
authors.forename: Antoinette
authors.initials: A
authors.lastname: Péchère-Bertschi
authors.affiliation: Department of Nephrology, Hypertension, and Clinical Pharmacology, University Hospital, University of Bern, Bern, Switzerland; and.
authors.forename: Bruno
authors.initials: B
authors.lastname: Vogt
authors.affiliation: Division of Nephrology, University Hospital of Lausanne, Lausanne, Switzerland;
authors.forename: Michel
authors.initials: M
authors.lastname: Burnier
authors.affiliation: Divisions of Nephrology and.
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Martin
authors.affiliation: Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Devuyst
authors.affiliation: Institute of Social and Preventive Medicine and Murielle.Bochud@chuv.ch.
authors.forename: Murielle
authors.initials: M
authors.lastname: Bochud
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001127:Arginine Vasopressin / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006020:Glycopeptides / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007677:Kidney Function Tests; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D007690:Polycystic Kidney Diseases / Q000378:metabolism* / Q000503:physiopathology*; D012016:Reference Values; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013557:Switzerland; D016482:Urinalysis
chemical_list: D015415:Biomarkers; D006020:Glycopeptides; C048197:copeptins; D001127:Arginine Vasopressin
keywords: albuminuria; cystic disease; renal function; renal morphology; vasopressin