title: Elatumic acid: a new ursolic acid congener from Omphalocarpum elatum Miers (Sapotaceae).
abstract: A new triterpene diastereomer, 1, of the previously reported 3beta,6beta,19alpha-trihydroxy-urs-12-en-28-oic acid-24-carboxylic acid methyl ester was obtained from the stem bark of Omphalocarpum elatum Miers (Sapotaceae) along with a-amyrin acetate (2), spinasterol (3), spinasterol 3-O-beta-D-glucopyranoside (4), and tormentic acid (5). The structures of the isolates were established on the basis of NMR and mass spectrometric data and by comparison with those previously reported in the literature. Compound 1 showed weak antibacterial activity against E. aerogenes ATCC13048 and EA3, K. pneumoniae ATCC29916, and P aeruginosa; it also displayed moderate cytotoxicity against CCRF-CEM, CEM/ADR5000, and MDA-MB231 cells.
authors.forename: Louis P
authors.initials: LP
authors.lastname: Sandjo
authors.forename: Chi G
authors.initials: CG
authors.lastname: Fru
authors.forename: Victor
authors.initials: V
authors.lastname: Kuete
authors.forename: Frederic
authors.initials: F
authors.lastname: Nana
authors.forename: Samuel O
authors.initials: SO
authors.lastname: Yeboah
authors.forename: Renameditswe
authors.initials: R
authors.lastname: Mapitse
authors.forename: Berhanu M
authors.initials: BM
authors.lastname: Abegaz
authors.forename: Thomas
authors.initials: T
authors.lastname: Efferth
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
authors.forename: Bonaventure T
authors.initials: BT
authors.lastname: Ngadjui
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029632:Sapotaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes; C000592425:elatumic acid