title: Subconjunctival bevacizumab to augment trabeculectomy with mitomycin C in the management of failed glaucoma surgery.
abstract: OBJECTIVE
  To provide a feasible solution to the problem of failed glaucoma surgery. The aim was to evaluate the efficacy and safety of the additional effects of a combined surgical approach. This approach augments the application of trabeculectomy with mitomycin C (MMC) by adding subconjunctival bevacizumab injection. The results were compared with those of trabeculectomy with only adjunctive MMC.
  
  
  METHODS
  A randomized controlled prospective clinical trial included 28 eyes diagnosed with failed scarred bleb of a previous trabeculectomy. The eyes were divided into two equal groups: combined group A, "trabeculectomy with adjunctive MMC and subconjunctival bevacizumab," and control group B, "trabeculectomy with adjunctive MMC only." The main outcome results included the cumulative probability of surgical success, intraocular pressure (IOP) values, and number of IOP-lowering medications needed to achieve the target IOP.
  
  
  RESULTS
  Group A achieved a cumulative probability of complete success of 0.769 and of qualified success of 0.231 at the end of the 24 month study period; group B achieved cumulative probabilities of 0.538 and 0.308, respectively. Group A achieved a lower mean IOP value than group B, with fewer antiglaucoma drugs at all postoperative visits, but this lower value did not reach a statistically significant level (P>0.05). There was no statistically significant difference between both groups regarding best corrected visual acuity, visual field parameters, operative and/or postoperative complications, and additional interventions. No significant adverse effects were caused by this combined approach.
  
  
  CONCLUSIONS
  Bevacizumab was not found to add much to the favorable long-term outcome of conventional trabeculectomy with MMC as a solution to the problem of scarred failed bleb.
authors.affiliation: Ophthalmology Department, Benha University, Egypt.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Saeed
authors.affiliation: Ophthalmology Department, Benha University, Egypt.
authors.forename: Tarek Tawfeek
authors.initials: TT
authors.lastname: AboulNasr
keywords: bevacizumab; bleb failure; failed trabeculectomy; glaucoma; mitomycin C; scarred bleb