title: Accidental overdose of travoprost.
abstract: OBJECTIVE
  To report systemic symptoms after an overdose of travoprost.
  
  
  METHODS
  We report a patient who, instead of artificial tears, inadvertently used travoprost every 15 minutes for 7 hours after LASIK (laser-assisted in situ keratomileusis) surgery. She experienced abrupt, severe abdominal cramps and sudden, severe menstrual bleeding, which subsided quickly upon discontinuation of the drug.
  
  
  CONCLUSIONS
  Because of the few systemic adverse effects, prostaglandin analogs are widely used for the treatment of glaucoma. Travoprost should be taken once daily; therefore, overdose is extremely uncommon. Systemic prostaglandins have been found to be mediators of uterine activity and are used to induce labor and terminate pregnancies. The high dose of this topical medication, as well as the compromised cornea, makes this case unique. The unusual circumstances observed in this case greatly expand our knowledge regarding the potential adverse effects of travoprost.
authors.affiliation: *OD, FAAO Pacific University College of Optometry, Forest Grove, Oregon (both authors).
authors.forename: Denise
authors.initials: D
authors.lastname: Goodwin
authors.forename: Dina H
authors.initials: DH
authors.lastname: Erickson
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced*; D000328:Adult; D000959:Antihypertensive Agents / Q000506:poisoning*; D003008:Cloprostenol / Q000031:analogs & derivatives* / Q000506:poisoning; D003085:Colic / Q000139:chemically induced*; D003315:Cornea / Q000187:drug effects; D062787:Drug Overdose; D005140:Eyelashes / Q000187:drug effects; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer; D065346:Lubricant Eye Drops / Q000008:administration & dosage; D008599:Menstruation Disturbances / Q000139:chemically induced*; D009883:Ophthalmic Solutions; D000069557:Travoprost
chemical_list: D000959:Antihypertensive Agents; D065346:Lubricant Eye Drops; D009883:Ophthalmic Solutions; D003008:Cloprostenol; D000069557:Travoprost