title: [The entry of Epstein-Barr virus into B lymphocytes and epithelial cells during infection].
abstract: Epstein-Barr virus (EBV) is a human herpesvirus associated with important human diseases, including infectious mononucleosis syndrome, malignant lymphoma, and nasopharyngeal carcinoma. The mechanism of EBV entry into host cells remains a subject of intensive research. After decades of study, researchers have identified several key proteins and different patterns of EBV intrusion into host cells. The viral surface glycoproteins, gp350/220, gp42, gB, gH, and gL, are involved in interactions with the CR2 receptor on the surface of B lymphocytes during viral entry. However, the majority of epithelial cells lack CR2 receptor expression, which makes viral invasion much more complex than in B lymphocytes. Three different models have been proposed to explain how EBV enters epithelial cells: (1) "transfer of infection", mediated by B lymphocytes or Langerhans cells; (2) EBV utilizes its own proteins during the process of fusion with the cell membrane; and (3) progeny virions arising from EBV-infected epithelial cells cross lateral membranes into adjacent epithelial cells. This review will discuss the relevant mechanism of viral entry into B lymphocytes and epithelial cells during EBV infection.
authors.forename: Lie-Lian
authors.initials: LL
authors.lastname: Zuo
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Zhu
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Du
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Lu
authors.forename: Gui-Yuan
authors.initials: GY
authors.lastname: Li
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D004847:Epithelial Cells / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D053586:Virus Internalization
chemical_list: D014764:Viral Proteins