title: Sequential rhodium/palladium catalysis: enantioselective formation of dihydroquinolinones in the presence of achiral and chiral ligands.
abstract: Compatible combinations of achiral and chiral ligands can be used in rhodium/palladium catalysis to achieve highly enantioselective domino reactions. The difference in rates of catalysis and minimal effects of ligand interference confer control in the domino sequence. The "all-in-one" 1,4-conjugate arylation and C-N cross-coupling through sequential Rh/Pd catalysis provides access to enantioenriched dihydroquinolinone building blocks.
authors.affiliation: Davenport Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6 (Canada).
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Zafar
authors.initials: Z
authors.lastname: Qureshi
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Sonaglia
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D002384:Catalysis; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D010165:Palladium; D012238:Rhodium
keywords: asymmetric catalysis; domino reactions; heterocycles; palladium; rhodium