title: IL-17RA in intestinal inflammation: structure, signaling, function, and clinical application.
abstract: : Interleukin-17 receptor A (IL-17RA) is responsible for both IL-17A and IL-25 (IL-17E) signaling pathways. Current evidences suggest distinct but interactive responses between IL-17A and IL-25 signaling, both of which are critical for intestinal immune homeostasis. IL-17RA is assumed to regulate this counterbalance and therefore becomes a crucial molecule in mucosal immunology. In this review, we will describe the structure of IL-17RA, compare IL-17A and IL-25 signaling pathways, and emphasize on the function of IL-17RA in intestinal inflammation and discuss current evidences of accomplished and ongoing clinical trials with monoclonal antibodies targeting Th17 pathway, especially IL-17RA.
authors.affiliation: *Department of Surgery, School of Medicine, Nanjing University, Jinling Hospital, Nanjing, China; and †Department of Medicine, Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
authors.forename: Song
authors.initials: S
authors.lastname: Liu
authors.forename: Jianan
authors.initials: J
authors.lastname: Ren
authors.forename: Jieshou
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D007422:Intestines / Q000187:drug effects / Q000276:immunology*; D053722:Receptors, Interleukin-17 / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D058504:Th17 Cells / Q000187:drug effects / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; C109985:IL17RA protein, human; C491673:Il17ra protein, mouse; D053722:Receptors, Interleukin-17