title: Pregnancy outcome of non-anonymous oocyte donation: a case-control study.
abstract: OBJECTIVE
  To evaluate the maternal and neonatal outcome of non-anonymous oocyte donation compared to in vitro fertilization. Study design We compared 84 oocyte donation pregnancies with a 251 matched in vitro fertilization cohort. Maternal and neonatal outcomes were retrieved from a nationwide perinatal registry. Oocyte donation and in vitro fertilization pregnancies were matched for maternal age, study center, ZIP code and embryo transfer date. Both maternal and neonatal complications and outcome were compared between oocyte donation and in vitro fertilization with univariate and multivariate logistic regression analyses, adjusting for maternal age, donor age, socio-economic status, ethnicity, and parity.
  
  
  RESULTS
  In total, 277 women underwent 541 oocyte donation cycles. The median recipient age was 34.9 years (IQR: 31.5-38.5), while the median donor age was 34.4 years (IQR: 31.7-37.0). Clinical pregnancy rate was 26.6%, which is comparable to standard in vitro fertilization treatment. Donor age in years (OR 0.93, 95% CI 0.88-0.99) and a previous pregnancy of the recipient (OR 1.69, 95% CI 1.02-2.78) were significantly associated with clinical pregnancy rate. Both singleton and multiple oocyte donation pregnancies were associated with pregnancy-induced hypertension compared with in vitro fertilization singleton and multiple pregnancies (OR 1.99, 95%CI 1.02-3.89, OR 6.43, 95% CI 1.67-24.72, respectively). No significant differences in neonatal outcome were observed.
  
  
  CONCLUSIONS
  Oocyte donation pregnancies are associated with an increased incidence of pregnancy-induced hypertension compared with age-matched in vitro fertilization controls. However, no significant differences in neonatal outcome were observed between oocyte donation and in vitro fertilization.
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands; Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. Electronic address: w.vandorp@erasmusmc.nl.
authors.forename: Wendy
authors.initials: W
authors.lastname: van Dorp
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Annemarie M
authors.initials: AM
authors.lastname: Rietveld
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Joop S E
authors.initials: JS
authors.lastname: Laven
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands; Department of Paediatric Oncology/Haematology, Erasmus MC-Sophia Children's Hospital, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.
authors.forename: Marry M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands; The Netherlands Perinatal Registry, PO Box 8588, 3503 RN Utrecht, The Netherlands.
authors.forename: Chantal W P M
authors.initials: CW
authors.lastname: Hukkelhoven
authors.affiliation: Department of Gynaecology and Obstetrics, Division Reproductive Medicine, Erasmus MC-University Medical Centre Rotterdam, s'Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands.
authors.forename: Izaäk
authors.initials: I
authors.lastname: Schipper
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology*; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D002585:Cesarean Section; D005260:Female; D005307:Fertilization in Vitro; D020073:Gravidity; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology*; D008423:Maternal Age; D018587:Oocyte Donation / Q000379:methods; D011225:Pre-Eclampsia / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D059286:Pregnancy, Triplet; D059285:Pregnancy, Twin
keywords: Oocyte donation; Pregnancy outcome; Pregnancy-induced hypertension