title: [Application of target peptide in siRNA delivery  for the research of lung cancer therapy].
abstract: Lung cancer is considered a kind of malignant tumors of the world highest incidence. As it is not sensitive to chemotherapy and easy to produce drug resistance, improving effect of anticancer drug becomes a research focus recent years. siRNA, small interfering RNA, can silence complemenary mRNA which is a kind of gene therapy. Target peptides are small molecular peptides which specifically bind to tumor surface materials. When used with siRNA, target peptides can increase accumulation of siRNA in tumor cells and enhance the silencing effect. As result, drug resistance of lung cancer reduced and the effect of therapy can be improved. This method provides new direction and strategy for targeted therapy of lung cancer. This article will make a brief overview of target peptides applying in siRNA dilivery for the research of lung cancer treatment.
authors.affiliation: Department of Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine,  Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192, China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine,  Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192, China.
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine,  Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192, China.
authors.forename: Naling
authors.initials: N
authors.lastname: Song
mesh_terms: D000595:Amino Acid Sequence; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000628:therapy*; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D010455:Peptides; D034741:RNA, Small Interfering