title: The protective role of bee honey against the toxic effect of melamine in the male rat kidney.
abstract: This study aimed to test the protective role of natural bee honey against melamine toxicity in the kidney of male albino rats. The dietary supplementation of melamine at a dose of 20,000 ppm for 28 days induced renal dysfunction, as reflected by a significant increase in kidney function parameters (urea, creatinine, and uric acid) and an increase in potassium levels. In addition, a decrease in catalase and glutathione-S-transferase and an increase in lipid peroxide in the kidney tissue homogenate were also observed. Histological changes in the melamine-treated group revealed hyperplasia and damage in kidney cells and the accumulation of melamine crystals in kidney tissues. Honey treatment for 28 days in rats concurrently administered melamine at a dose of 2.5 g/kg body weight for 28 days improved the kidney function, increased antioxidant enzymes, and decreased lipid peroxide levels. The morphology of the kidney cells of the melamine-fed rats was also improved as a result of honey treatment. In conclusion, this study revealed that natural bee honey protects the kidney against the adverse effects induced by melamine toxicity in male albino rats.
authors.affiliation: Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Madeha N
authors.initials: MN
authors.lastname: Al-Seeni
authors.affiliation: Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Genetic Engineering and Biotechnology Institute, Sadat City University, Sadat, Minufiya, Egypt elrabey@hotmail.com.
authors.forename: Haddad A
authors.initials: HA
authors.lastname: El Rabey
authors.affiliation: Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Suad M
authors.initials: SM
authors.lastname: Al-Solamy
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D006722:Honey; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D011188:Potassium / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D051437:Renal Insufficiency / Q000139:chemically induced*; D014227:Triazines / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D014227:Triazines; D002374:Catalase; D005982:Glutathione Transferase; C011907:melamine; D011188:Potassium
keywords: Melamine; catalase; creatinine; honey; kidney