title: Pharmacologic treatments for esophageal disorders.
abstract: The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on the role for ketamine and other alternative treatments in esophageal disorders; the use of linaclotide in the treatment of esophageal pain; the alginate test as a diagnostic criterion in gastroesophageal reflux disease (GERD); the use of baclofen in treatment of GERD; the effects of opioids on the esophagus; the use of antagonists on the receptor level in GERD; the effect of local formulation of drugs on the esophageal mucosa; and the use of electroencephalographic fingerprints to predict the effect of pharmacological treatment.
authors.affiliation: Centre for Digestive Diseases, Blizard Institute of Cell & Molecular Science, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, United Kingdom.
authors.forename: L Ashley
authors.initials: LA
authors.lastname: Blackshaw
authors.forename: Dmitry S
authors.initials: DS
authors.lastname: Bordin
authors.forename: Christina
authors.initials: C
authors.lastname: Brock
authors.forename: Anne
authors.initials: A
authors.lastname: Brokjaer
authors.forename: Asbjørn Mohr
authors.initials: AM
authors.lastname: Drewes
authors.forename: Adam D
authors.initials: AD
authors.lastname: Farmer
authors.forename: Anne Lund
authors.initials: AL
authors.lastname: Krarup
authors.forename: Christian
authors.initials: C
authors.lastname: Lottrup
authors.forename: Antonina A
authors.initials: AA
authors.lastname: Masharova
authors.forename: Fouad J
authors.initials: FJ
authors.lastname: Moawad
authors.forename: Anne Estrup
authors.initials: AE
authors.lastname: Olesen
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001418:Baclofen / Q000494:pharmacology / Q000627:therapeutic use; D017615:Enteric Nervous System / Q000187:drug effects / Q000473:pathology; D004935:Esophageal Diseases / Q000175:diagnosis* / Q000188:drug therapy*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D010146:Pain / Q000175:diagnosis* / Q000188:drug therapy*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use; D058914:Purinergic Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000701:Analgesics, Opioid; D010455:Peptides; D058914:Purinergic Antagonists; D001418:Baclofen; C523483:linaclotide
keywords: EEG; OESO; alginate test; baclofen; esophagus; gastroesophageal reflux disease; ketamine; linaclotide; opiods; pharmacology