title: [Resting-state functional magnetic resonance imaging of first-onset major depressive disorder: analysis of 18 cases].
abstract: OBJECTIVE
  To investigate the changes in brain regional homogeneity in first-onset major depressive disorders (MDDs) using resting-state functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  Eighteen patients with first-onset MDDs and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional homogeneities of the brain regions.
  
  
  RESULTS
  Compared with the normal controls, the patients with MDDs showed significantly decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe.
  
  
  CONCLUSIONS
  Patients with first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.
authors.affiliation: Department of Radiology, Guangdong General Hospital, Guangzhou 510000, China. E-mail: yingxiao315@163.com.
authors.forename: Mouying
authors.initials: M
authors.lastname: Guo
authors.forename: Shuixing
authors.initials: S
authors.lastname: Zhang
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Xu
authors.forename: Xueyu
authors.initials: X
authors.lastname: Hu
authors.forename: Chengjia
authors.initials: C
authors.lastname: Yang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Chen
mesh_terms: D000679:Amygdala; D001921:Brain / Q000503:physiopathology*; D016022:Case-Control Studies; D002531:Cerebellum; D003071:Cognition; D003865:Major Depressive Disorder / Q000175:diagnosis*; D004644:Emotions; D005625:Frontal Lobe; D006801:Humans; D008279:Magnetic Resonance Imaging; D013702:Temporal Lobe