title: [Studies of local anaesthetics: part 205* studies of stability of heptacainium chloride and carbisocainium chloride using an accelerated non-isothermal test].
abstract: The paper studies the kinetics of alkaline hydrolysis and stability under non-isothermal conditions of heptacainium chloride and carbisocainium chloride in the medium of aqueous-ethanolic solution of sodium hydroxide c = 0.1 mol/l and buffer solutions of values of pH 7.0 and pH 8.0. The results of the study of the kinetics of hydrolysis by means of a non-isothermal test - rate constants and activation energy values served as the basis for exact evaluation of the stability of these potential pharmaceuticals. The objective of the paper links up with the previous studies of these substances.
authors.forename: Mária
authors.initials: M
authors.lastname: Stankovičová
authors.forename: Andrea
authors.initials: A
authors.lastname: Lašáková
authors.forename: Veronika
authors.initials: V
authors.lastname: Medlenová
authors.forename: Zelmíra
authors.initials: Z
authors.lastname: Bezáková
authors.forename: Jozef
authors.initials: J
authors.lastname: Cižmárik
mesh_terms: D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D010880:Piperidines / Q000737:chemistry*; D012972:Sodium Hydroxide / Q000737:chemistry; D012996:Solutions; D014867:Water / Q000737:chemistry
chemical_list: D000779:Anesthetics, Local; D002219:Carbamates; D010880:Piperidines; D012996:Solutions; D014867:Water; C013549:heptacaine; D012972:Sodium Hydroxide; C046030:carbizocaine