title: A basic germanodecatungstate with a -7 charge: efficient chemoselective acylation of primary alcohols.
abstract: The synthesis of highly negatively charged polyoxometalates with electrically and structurally controlled uniform basic sites can lead to the unique base catalysis. In this work, a γ-Keggin germanodecatungstate, [γ-HGeW10O36](7-) (A), having a -7 charge was, for the first time, successfully synthesized by the reaction of [γ-H2GeW10O36](6-) with one equivalent of [(n-C4H9)4N]OH under non-aqueous conditions. The activities of germanodecatungstates for base-catalyzed reactions dramatically increased with increase in the number negative charges from -6 to -7. In the presence of A, various combinations of acylating agents and primary alcohols including those with acid-sensitive functional groups chemoselectively gave the desired acylated products in high yields even under the stoichiometric conditions.
authors.affiliation: Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan) http://park.itc.u-tokyo.ac.jp/mizuno/
authors.forename: Kosei
authors.initials: K
authors.lastname: Sugahara
authors.forename: Naoto
authors.initials: N
authors.lastname: Satake
authors.forename: Keigo
authors.initials: K
authors.lastname: Kamata
authors.forename: Takahito
authors.initials: T
authors.lastname: Nakajima
authors.forename: Noritaka
authors.initials: N
authors.lastname: Mizuno
keywords: acylation; alcohols; heterogeneous catalysis; polyoxometalates; synthetic methods