title: Synthesis and antimicrobial activities of oxazepine and oxazocine derivatives.
abstract: A series of annulated 7-membered oxazepine and 8-membered oxazocine derivatives were synthesized by photoreaction of phthalimide derivatives and an alkene. The antimicrobial activities of the synthesized compounds were evaluated, and compounds 18 and 20 exhibited best antibacterial activity against Gram-positive bacteria. The relationships between structure (especially steric structure) and antimicrobial activities are discussed.
authors.forename: Jian
authors.initials: J
authors.lastname: Tang
authors.forename: Yu-Liang
authors.initials: YL
authors.lastname: Jiang
authors.forename: Bing-Xiang
authors.initials: BX
authors.lastname: Wang
authors.forename: Yong-Miao
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D010077:Oxazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D010079:Oxazocines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D010077:Oxazepines; D010079:Oxazocines