title: Dipyrone has no effects on bone healing of tibial fractures in rats.
abstract: OBJECTIVE
  To evaluate the effect of dipyrone on healing of tibial fractures in rats.
  
  
  METHODS
  Fourty-two Wistar rats were used, with mean body weight of 280g. After being anesthetized, they were submitted to closed fracture of the tibia and fibula of the right posterior paw through manual force. The rats were randomly divided into three groups: the control group that received a daily intraperitoneal injection of saline solution; group D-40, that received saline injection containing 40mg/Kg dipyrone; and group D-80, that received saline injection containing 80mg/Kg dipyrone. After 28 days the rats were sacrificed and received a new label code that was known by only one researcher. The fractured limbs were then amputated and X-rayed. The tibias were disarticulated and subjected to mechanical, radiological and histological evaluation. For statistical analysis the Kruskal-Wallis test was used at a significance level of 5%.
  
  
  RESULTS
  There wasn't any type of dipyrone effect on healing of rats tibial fractures in relation to the control group.
  
  
  CONCLUSIONS
  Dipyrone may be used safely for pain control in the treatment of fractures, without any interference on bone healing. Level of Evidence II, Controlled Laboratory Study.
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Gali
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Dennis
authors.initials: D
authors.lastname: Sansanovicz
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Fernando Carvalho
authors.initials: FC
authors.lastname: Ventin
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Rodrigo Henrique
authors.initials: RH
authors.lastname: Paes
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Francisco Carlos
authors.initials: FC
authors.lastname: Quevedo
authors.affiliation: Pontifícia Universidade Católica de São Paulo, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Sorocaba, SP, Brazil, Faculdade de Ciências Médicas e da Saúde de Sorocaba, Pontifícia Universidade Católica de São Paulo, Sorocaba, SP, Brazil.
authors.forename: Edie Benedito
authors.initials: EB
authors.lastname: Caetano
keywords: Fracture healing/drug effects; Rats; Tibial fractures