title: Brain resuscitation and prognosis after cardiac arrest.
abstract: Brain injury represents the major cause of long-term disability and mortality among patients resuscitated from cardiac arrest. Brain-directed therapies include maintenance of normal oxygenation, hemodynamic support to optimize cerebral perfusion, glycemic control, and targeted temperature management. Pertinent guidelines and recommendations are reviewed for brain-directed treatment. The latest clinical trial data regarding targeted temperature management are also reviewed. Contemporary prognostication among initially comatose cardiac arrest survivors uses a combination of clinical and electrophysiologic tests. The most recent guidelines for prognostication after cardiac arrest are reviewed. Ongoing research regarding the effects of induced hypothermia on prognostic algorithms is also reviewed.
authors.affiliation: The Queen's Medical Center, Neuroscience Institute, 1301 Punchbowl Street, QET5, Honolulu, HI 96813, USA. Electronic address: mkoenig@queens.org.
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Koenig
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001930:Brain Injuries / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D003128:Coma / Q000209:etiology / Q000628:therapy*; D005260:Female; D006323:Heart Arrest / Q000150:complications* / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011379:Prognosis; D055815:Young Adult
keywords: Cardiac arrest; Coma; Hypoxic-ischemic encephalopathy; Induced hypothermia; Prognostication