title: Significance of AKT in gastric cancer (Review).
abstract: AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro-proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular-targeted agents. When analyzing the role of AKT in cancer cells, it is important to consider the microenvironment and variations of cancers. In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, along with an in-depth discussion of its role in gastric cancer and its potential as a target for therapy.
authors.affiliation: Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Jonan‑ku, Fukuoka 814‑0180, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Sasaki
authors.affiliation: Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kuniyasu
mesh_terms: D063646:Carcinogenesis; D049109:Cell Proliferation / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000235:genetics; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D051058:Oncogene Protein v-akt / Q000235:genetics*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D009363:Neoplasm Proteins; D051058:Oncogene Protein v-akt