title: Stability of new anticonvulsant derivatives of picolinic, nicotinic, cyclocarboxylic acids in body fluids and tissues.
abstract: The stability of new compounds with established anticonvulsant activity: picolinic acid 4-pyridyl-methylamide (Pic-4-PMA), cyclopentanecarboxylic acid benzylamide (Cpc-BZA), cycloheptanecarboxylic acid benzylamide (Chc-BZA), picolinic acid 2-fluoro-3-trifluoromethylbenzylamide (Pic-2F-3TFM-BZA), 2-chloronicotinic acid benzylamide (2-Cl-Na-BZA), 6-chloronicotinic acid benzylamide (6-Cl-Na-BZA) and 6-trifluoromethylnicotinic acid benzylamide (6-TFM-Na-BZA) in homogenates of body organs and in body fluids was determined after incubation. It was found that three compounds were stable against enzymes present in body fluids and organs and two were found to decompose in liver and kidney homogenates and two decomposed only in liver homogenate.
authors.forename: Dorota
authors.initials: D
authors.lastname: Marszałek
authors.forename: Anna
authors.initials: A
authors.lastname: Goldnik
authors.forename: Aleksander P
authors.initials: AP
authors.lastname: Mazurek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Balicka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Koziorowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Hermanowicz
authors.forename: Monika
authors.initials: M
authors.lastname: Łuka
authors.forename: Milena
authors.initials: M
authors.lastname: Piatkowska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Grodzka
authors.forename: Sylwia
authors.initials: S
authors.lastname: Kumorowska
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry*; D001826:Body Fluids / Q000378:metabolism; D002264:Carboxylic Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D009539:Nicotinic Acids / Q000737:chemistry*; D010848:Picolinic Acids / Q000737:chemistry*; D013552:Swine
chemical_list: D000927:Anticonvulsants; D002264:Carboxylic Acids; D009539:Nicotinic Acids; D010848:Picolinic Acids