title: Gangliocytomas in the sellar region.
abstract: Gangliocytomas occurring in the sellar region are extremely rare. We examined a cohort of these tumors to examine their clinical presentations and prognoses. Between January 2000 and December 2012, 23 patients were diagnosed with sellar region gangliocytomas in Huashan Hospital. These patients were retrospectively reviewed for medical histories, endocrinological examinations, preoperative magnetic resonance imaging (MRI), pathological findings and follow-ups. Endocrinological tests revealed elevated prolactin (PRL) levels in 10 cases (43.5%) and elevated growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels in 9 cases (39.1%). Scattered ganglion cells admixed with adenomatous components were observed in 16 cases (69.6%). In the remaining 7 cases (30.4%), only fragments with ganglion cells dispersed in the fibrillar matrix without adenohypophyseal components were detected. Immunohistochemistry revealed PRL-positive adenomas in 6 cases (26.1%) and GH-positive adenomas in 8 cases (34.8%). The average follow-up period was 4.2 years (range: 1-12.7 years). Gross total resection was achieved in 20 cases (87.0%). One patient recurred five years after tumor resection (4.3%). One patient died of acute myocardial infarction six years after operation. Gangliocytomas located in the sellar region may represent a unique immunopathological entity. The surgical results and prognoses of the gangliocytomas were comparable with those of pituitary adenomas.
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Nidan
authors.initials: N
authors.lastname: Qiao
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ye
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Shiqi
authors.initials: S
authors.lastname: Li
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Mao
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Weimin
authors.initials: W
authors.lastname: Bao
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Che
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.affiliation: Department of Neuro-pathology, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Xuefei
authors.initials: X
authors.lastname: Shou
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, FuDan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China. Electronic address: zhaoyaohs@hotmail.com.
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D015331:Cohort Studies; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000601:surgery; D012658:Sella Turcica / Q000473:pathology*; D055815:Young Adult
keywords: Gangliocytoma; Prognosis; Sellar region; Surgery