title: Bmi-1 regulates the migration and invasion of glioma cells through p16.
abstract: Bmi-1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi-1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi-1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi-1 could be rescued by p16 downregulation. These results show that Bmi-1 contributes to the motility of glioma cells by regulating the expression of p16.
authors.affiliation: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, 99 West Huai-hai Road, Xuzhou, Jiangsu, 221002, P. R. China; Lab of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu, P. R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Shao
authors.initials: S
authors.lastname: Xie
authors.forename: Weifeng
authors.initials: W
authors.lastname: Wang
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhou
authors.forename: Jinxia
authors.initials: J
authors.lastname: Hu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shi
authors.forename: Xianli
authors.initials: X
authors.lastname: Zhang
authors.forename: Rutong
authors.initials: R
authors.lastname: Yu
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D009361:Neoplasm Invasiveness; D063150:Polycomb Repressive Complex 1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism
chemical_list: C069077:BMI1 protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D034741:RNA, Small Interfering; D063150:Polycomb Repressive Complex 1; D020778:Matrix Metalloproteinase 2
keywords: Bmi-1; glioma; invasion; migration; p16