title: A systematic review of the effects of diffuse optical imaging in breast diseases.
abstract: BACKGROUND
  Optical mammography is a new diagnostic method that uses Near-infrared for detection of functional abnormalities and shows tissue activities by measuring absorption and scattering of Near-infrared light. This study aims to evaluate the safety and effectiveness of this technology.
  
  
  METHODS
  Cochrane Library (Issue 10, 2012) and Medline (Nov 2012) weresearched using free text and Mesh. Studies that compared optical mammography with other diagnostic methods and used outcomes such as sensitivity, specificity and safety were included.
  
  
  RESULTS
  Twelve studies were included in this review. A multicenter RCT showed that among 875 biopsied lesions, suspicion index led to 97% sensitivity, 14%specificity, 95% negative predictive value and 24% positive predictive value. In terms of oxygenation index, the included studies found that the process should be used with various wavelengths compared to single wavelength technique (690, 750, 788, 856 nm or 683, 912, 975nm). In terms of sensitivity and specificity, Diffuse Optical Tomography Computer Aided Detection is capable of distinguishing healthy tissues from malignant ones with 89% sensitivity and 94% specificity. Also, this technology could show increased blood flow around the tumor tissue compared to the healthy tissue effectively. Included studies did not report any information about the effects of technology on changing the treatment process or the final health outcomes.
  
  
  CONCLUSIONS
  Optical mammography is a safe, noninvasive, non-ionized diagnostic technology that can be used as a diagnostic supplement alongside conventional mammography for differentiating benign and malignant tumors. Women with higher breast density should be screened at younger ages and with more persistence than those who have lower densities.
authors.affiliation: Dept. of Health Management and Economics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Akbari Sari
authors.affiliation: Dept. of Health Service Management, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mobinizadeh
authors.affiliation: Dept. of Economics, University of Applied Science and Technology, Kohdasht Branch, Lorestan, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Azadbakht
keywords: Breast cancer; Diffuse optical imaging; Near-infrared spectroscopy; Optical mammography