title: A continuum model for platelet plug formation, growth and deformation.
abstract: A numerical framework for modelling platelet plug dynamics is presented in this work. It consists of an extension of a biochemical and plug growth model with a solid mechanics model for the plug coupled with a fluid-structure interaction model for the blood flow-plug system. The platelet plug is treated as a neo-Hookean elastic solid, of which the implementation is based on an updated Lagrangian approach. The framework is applied to different haemodynamic configurations coupled with different shear moduli of the plug. Results about plug growth, shape and size, as well as the stress distribution, are shown. Based on the simulations performed, we conclude that the deformability of the platelet plug is essential for its growth.
authors.affiliation: Cardiovascular Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB, Eindhoven, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Storti
authors.forename: F N
authors.initials: FN
authors.lastname: van de Vosse
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology; D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D008955:Models, Cardiovascular
keywords: continuum model; fluid-structure interaction; haemodynamics; platelet plug development; platelet plug stress; updated Lagrangian formulation