title: Biogenesis of Circular RNAs.
abstract: Circular RNAs are generated during splicing through various mechanisms. Ashwal-Fluss et al. demonstrate that exon circularization and linear splicing compete with each other in a tissue-specific fashion, and Zhang et al. show that exon circularization depends on flanking intronic complementary sequences. Both papers show that several types of circular RNA transcripts can be produced from a single gene.
authors.affiliation: Institut de biologie moléculaire et cellulaire du CNRS, Architecture et Réactivité de l'ARN, 67 084 Strasbourg, France. Electronic address: q.vicens@ibmc-cnrs.unistra.fr.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Vicens
authors.affiliation: Institut de biologie moléculaire et cellulaire du CNRS, Architecture et Réactivité de l'ARN, 67 084 Strasbourg, France. Electronic address: e.westhof@ibmc-cnrs.unistra.fr.
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics*; D006801:Humans; D012313:RNA / Q000096:biosynthesis*; D012322:RNA Precursors / Q000378:metabolism*; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism*
chemical_list: D012322:RNA Precursors; D012333:RNA, Messenger; D012313:RNA