title: Nonpenetrating deep sclerectomy as an effective treatment of glaucoma related to familial amyloid polyneuropathy.
abstract: OBJECTIVE
  To present the clinical course and treatment by nonpenetrating deep sclerectomy (NPDS) of open-angle glaucoma secondary to familial amyloid polyneuropathy (FAP).
  
  
  METHODS
  In a series of 10 patients with FAP in a tertiary ophthalmology center, 4 eyes of 3 patients required glaucoma filtration surgery and NPDS with implant, and local intraoperative mitomycin C application was performed. Intraocular pressure and anatomic bleb functionality were measured. We performed a retrospective review of data from medical charts of the 10 FAP patients, which included demographics, incidence and treatment of glaucoma, and previous vitrectomy.
  
  
  RESULTS
  NPDS resulted in normalization of intraocular pressure in all 4 eyes. Ten eyes (6 patients) of the studied group underwent vitrectomy because of amyloid opacities, 7 eyes (4 patients) had glaucoma, 6 of the eyes with glaucoma were previously vitrectomized, and 4 of them subsequently required glaucoma surgery.
  
  
  CONCLUSIONS
  NPDS is an effective treatment of FAP glaucoma. Previously vitrectomized eyes have a more severe course of glaucoma and more frequently require filtration surgery.
authors.affiliation: *Department of Ophthalmology, Hospital Clinic of Barcelona, Barcelona, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Latasiewicz
authors.forename: Elena
authors.initials: E
authors.lastname: Millá
authors.forename: Juan
authors.initials: J
authors.lastname: Giralt
authors.forename: Juan Jose
authors.initials: JJ
authors.lastname: Molina
authors.forename: Jessica
authors.initials: J
authors.lastname: Matas
mesh_terms: D000328:Adult; D000368:Aged; D028227:Amyloid Neuropathies, Familial / Q000150:complications*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012590:Sclera / Q000601:surgery*; D012599:Sclerostomy / Q000379:methods*; D014065:Tonometry, Ocular; D016896:Treatment Outcome; D014821:Vitrectomy