title: Anticancer activities of citrus peel polymethoxyflavones related to angiogenesis and others.
abstract: Citrus is a kind of common fruit and contains multiple beneficial nutrients for human beings. Flavonoids, as a class of plant secondary metabolites, exist in citrus fruits abundantly. Due to their broad range of pharmacological properties, citrus flavonoids have gained increased attention. Accumulative in vitro and in vivo studies indicate protective effects of polymethoxyflavones (PMFs) against the occurrence of cancer. PMFs inhibit carcinogenesis by mechanisms like blocking the metastasis cascade, inhibition of cancer cell mobility in circulatory systems, proapoptosis, and antiangiogenesis. This review systematically summarized anticarcinogenic effect of citrus flavonoids in cancer therapy, together with the underlying important molecular mechanisms, in purpose of further exploring more effective use of citrus peel flavonoids.
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
authors.forename: Liwen
authors.initials: L
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China ; Institute of Radiation Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
authors.forename: Jinhan
authors.initials: J
authors.lastname: Wang
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
authors.forename: Lianying
authors.initials: L
authors.lastname: Fang
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
authors.forename: Zuliang
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
authors.forename: Dexian
authors.initials: D
authors.lastname: Zhi
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.
authors.forename: Suying
authors.initials: S
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang, Hubei 438000, China ; Department of Food Science, Rutgers University, New Brunswick, NJ 08901-8502, USA.
authors.forename: Shiming
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Food Science, Rutgers University, New Brunswick, NJ 08901-8502, USA.
authors.forename: Chi-Tang
authors.initials: CT
authors.lastname: Ho
authors.affiliation: Tianjin Key Laboratory of Food and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China ; Department of Hematology and Translation Medicine Centre, Hebei Union University Affiliated Hospital, Tangshan, Hebei 063000, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002957:Citrus / Q000737:chemistry*; D047309:Flavones / Q000008:administration & dosage* / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D047309:Flavones; D010936:Plant Extracts