title: Translational research on Barrett's esophagus.
abstract: The following, from the 12th OESO World Conference: Cancers of the Esophagus, includes commentaries on translational research on Barrett's esophagus that address evidence for genetic instability in esophageal cancer; the role of microsatellite instability; the use of histologic and serum Doublecortin-like kinase 1 expression for progression of Barrett's esophagus to adenocarcinoma; the oxidative stress in Barrett's tumorigenesis; the genomic alterations in esophageal cancer; in vivo modeling in Barrett's esophagus; epigenetic and transcriptional regulation in Barrett's esophagus and esophageal adenocarcinoma; and normal and disordered regeneration in Barrett's esophagus.
authors.affiliation: Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.
authors.forename: Anushka
authors.initials: A
authors.lastname: Baruah
authors.forename: Navtej
authors.initials: N
authors.lastname: Buttar
authors.forename: Raghav
authors.initials: R
authors.lastname: Chandra
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Chen
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Clemons
authors.forename: Debora
authors.initials: D
authors.lastname: Compare
authors.forename: Wael
authors.initials: W
authors.lastname: El-Rifai
authors.forename: Jian
authors.initials: J
authors.lastname: Gu
authors.forename: Courtney W
authors.initials: CW
authors.lastname: Houchen
authors.forename: Shze Yung
authors.initials: SY
authors.lastname: Koh
authors.forename: Wenbo
authors.initials: W
authors.lastname: Li
authors.forename: Gerardo
authors.initials: G
authors.lastname: Nardone
authors.forename: Wayne A
authors.initials: WA
authors.lastname: Phillips
authors.forename: Anamay
authors.initials: A
authors.lastname: Sharma
authors.forename: Ishtpreet
authors.initials: I
authors.lastname: Singh
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Upton
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Vega
authors.forename: Xifeng
authors.initials: X
authors.lastname: Wu
mesh_terms: D000818:Animals; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D014408:Biomarkers, Tumor / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D010297:Paris; D057170:Translational Research, Biomedical / Q000379:methods* / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor
keywords: Barrett's esophagus; DCLK; OESO; esophageal adenocarcinoma; microsatellite instability; modeling; oxidative stress