title: Innovation of novel antibiotics: an economic perspective.
abstract: Despite the public attention to antibiotic overuse and the specter of antimicrobial-resistant pathogens, current infections necessitate the use of antibiotics. Yet, patients and providers may not fully consider the societal cost associated with inappropriate antimicrobial use and subsequent resistance. Policies intended to limit use to minimize resistance must be balanced with the competing concern of underutilization. It is difficult to determine whether research and development incentives or reducing the costs of bringing new antibiotics through expedited review will be sufficient. Likely, the most effective method would be allowing higher prices for use deemed to be clinically appropriate. The ultimate policy goal is to ensure that antibiotics are used appropriately, with the right patients receiving the right medication at the right time, and that the world has a steady stream of future antibiotics to effectively treat the resistant organisms that will inevitably emerge.
authors.affiliation: School of Public Health.
authors.forename: Michael R
authors.initials: MR
authors.lastname: McKellar
authors.affiliation: School of Public Health Medical School, University of Michigan, Ann Arbor.
authors.forename: A Mark
authors.initials: AM
authors.lastname: Fendrick
mesh_terms: D000900:Anti-Bacterial Agents / Q000191:economics*; D035843:Biomedical Research / Q000191:economics / Q000639:trends; D004345:Drug Industry / Q000191:economics / Q000639:trends; D004351:Drug Resistance; D015507:Drugs, Investigational / Q000191:economics*
chemical_list: D000900:Anti-Bacterial Agents; D015507:Drugs, Investigational
keywords: antibiotics; incentives; innovation; pharmaceuticals; resistance