title: IVUS-based FSI models for human coronary plaque progression study: components, correlation and predictive analysis.
abstract: Atherosclerotic plaque progression is believed to be associated with mechanical stress conditions. Patient follow-up in vivo intravascular ultrasound coronary plaque data were acquired to construct fluid-structure interaction (FSI) models with cyclic bending to obtain flow wall shear stress (WSS), plaque wall stress (PWS) and strain (PWSn) data and investigate correlations between plaque progression measured by wall thickness increase (WTI), cap thickness increase (CTI), lipid depth increase (LDI) and risk factors including wall thickness (WT), WSS, PWS, and PWSn. Quarter average values (n = 178-1016) of morphological and mechanical factors from all slices were obtained for analysis. A predictive method was introduced to assess prediction accuracy of risk factors and identify the optimal predictor(s) for plaque progression. A combination of WT and PWS was identified as the best predictor for plaque progression measured by WTI. Plaque WT had best overall correlation with WTI (r = -0.7363, p < 1E-10), cap thickness (r = 0.4541, p < 1E-10), CTI (r = -0.4217, p < 1E-8), LD (r = 0.4160, p < 1E-10), and LDI (r = -0.4491, p < 1E-10), followed by PWS (with WTI: (r = -0.3208, p < 1E-10); cap thickness: (r = 0.4541, p < 1E-10); CTI: (r = -0.1719, p = 0.0190); LD: (r = -0.2206, p < 1E-10); LDI: r = 0.1775, p < 0.0001). WSS had mixed correlation results.
authors.affiliation: Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Zheyang
authors.initials: Z
authors.lastname: Wu
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Richard
authors.initials: R
authors.lastname: Bach
authors.forename: David
authors.initials: D
authors.lastname: Muccigrosso
authors.forename: Kristen
authors.initials: K
authors.lastname: Billiar
authors.forename: Akiko
authors.initials: A
authors.lastname: Maehara
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
authors.forename: Dalin
authors.initials: D
authors.lastname: Tang
mesh_terms: D000368:Aged; D018450:Disease Progression; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology; D012307:Risk Factors; D013314:Stress, Mechanical; D014463:Ultrasonography