title: Efficient approach to prepare multiple chemotherapeutic agent conjugated nanocarrier.
abstract: A pH-responsive, multiple chemotherapeutic agent derived nanocarrier has been synthesized by conjugating doxorubicin, indomethacin, and folate to the backbone of norbornene polymer. Drug molecules are connected to the norbornene backbone by an ester linker to demonstrate the pH-responsive capabilities. The complete chemical and biological properties of the new norbornene-based polymeric nanocarrier, intended for combination cancer chemotherapy, are discussed.
authors.affiliation: Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, India. sraja@iiserkol.ac.in.
authors.forename: Vijayakameswara Rao
authors.initials: VR
authors.lastname: N
authors.forename: Himadri
authors.initials: H
authors.lastname: Dinda
authors.forename: Mutyala Naidu
authors.initials: MN
authors.lastname: Ganivada
authors.forename: Jayasri
authors.initials: J
authors.lastname: Das Sarma
authors.forename: Raja
authors.initials: R
authors.lastname: Shunmugam
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry / Q000633:toxicity; D049329:Nanostructures / Q000737:chemistry*; D009636:Norbornanes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D009636:Norbornanes; D011108:Polymers; D004317:Doxorubicin; D007213:Indomethacin