title: Acuminolide A: structure and bioactivity of a new polyether macrolide from dinoflagellate Dinophysis acuminata.
abstract: Acuminolide A (1), along with pectenotoxin II (PTX-2), dinophysistoxin I (DTX-1), okadaic acid (OA), and 7-epi-PTX-2 seco acid, was isolated from a large-scale cultivation of the dinoflagellate Dinophysis acuminata. The new 33-membered macrolide 1 was characterized by detailed analysis of 2D NMR and MS data. Its relative stereochemistry was elucidated on the basis of ROESY correlations and J-based analysis. In contrast to the other well-known toxins that were isolated, 1 showed no cytotoxicity against four cancer cell lines but caused potent stimulation of actomyosin ATPase activity.
authors.affiliation: Department of Marine Biotechnology, Kunsan National University , Jeonbuk, 573-701, South Korea.
authors.forename: Buyng Su
authors.initials: BS
authors.lastname: Hwang
authors.forename: Heong Seop
authors.initials: HS
authors.lastname: Kim
authors.forename: Wonho
authors.initials: W
authors.lastname: Yih
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Jung-Rae
authors.initials: JR
authors.lastname: Rho
mesh_terms: D004141:Dinoflagellida / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000302:isolation & purification; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D009218:Myosins / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D019319:Okadaic Acid / Q000302:isolation & purification; D011714:Pyrans / Q000302:isolation & purification; D000095702:Polyether Toxins
chemical_list: D005663:Furans; D018942:Macrolides; D009218:Myosins; D019319:Okadaic Acid; D011714:Pyrans; C000599393:acuminolide A; C098380:pectenotoxin 2; D000095702:Polyether Toxins