title: A systematic review of the incidence and clinical significance of postoperative meniscus transplant extrusion.
abstract: OBJECTIVE
  To determine the incidence and clinical significance of postoperative meniscus transplant extrusion.
  
  
  METHODS
  A systematic search was performed using PubMed and Cochrane online databases. Inclusionary criteria were English language, clinical trials of meniscus transplantation published from 1984 to 2014, and meniscus extrusion measured on magnetic resonance imaging (MRI).
  
  
  RESULTS
  Twenty-three studies were included, in which 814 menisci were implanted into 803 patients. MRIs were obtained from 2 days to 10 years postoperatively. Eighteen studies used fresh-frozen meniscus transplants implanted with bone (n = 612) or suture fixation (n = 116); four studies, cryopreserved transplants; and one, irradiated transplants. Three measurements assessed extrusion: absolute millimeters of extrusion (0-8.8 mm), relative percentage of extrusion (0-100%), and the percent of transplants that were extruded (0-100 %). Relationships between transplant extrusion and clinical rating scales, joint space narrowing on standing radiographs, and arthrosis progression were inconclusive. Non-anatomic placement of lateral meniscus transplants and suture fixation of medial and lateral transplants were associated with greater extrusion in two studies.
  
  
  CONCLUSIONS
  Inconsistencies among studies prevent conclusions regarding the incidence and clinical significance of meniscus transplant extrusion. Even so, the short- to mid-term results were encouraging for knee function with daily activities and low rates of failure requiring transplant removal. A postoperative MRI showing more than 3-mm extrusion occurring in some studies suggested technique and/or implant sizing problems that required correction. Future studies should report absolute transplant extrusion, relative percent of extrusion, percent of transplant within the tibiofemoral compartment, and the percent of transplants that are extruded.
  
  
  METHODS
  IV.
authors.affiliation: Cincinnati Sportsmedicine and Orthopaedic Center, Noyes Knee Institute, Jewish Hospital - Mercy Health, 10663 Montgomery Rd., Cincinnati, OH, 45242, USA.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Noyes
authors.forename: Sue D
authors.initials: SD
authors.lastname: Barber-Westin
mesh_terms: D001178:Arthroplasty / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007719:Knee Joint / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008592:Menisci, Tibial / Q000601:surgery / Q000637:transplantation*; D011183:Postoperative Complications / Q000175:diagnosis; D016378:Tissue Transplantation / Q000009:adverse effects; D019737:Transplants