title: Tailoring the hydrophilic/lipophilic balance of clickable mesoporous organosilicas by the copper-catalyzed azide-alkyne cycloaddition click-functionalization.
abstract: We have designed and synthesized a clickable bridged silsesquioxane material featuring pendant alkyne chains as an aggregate of golf-ball-like nanoparticles, as evidenced by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and small- and wide-angle X-ray scattering (SWAXS). Using the copper-catalyzed azide-alkyne cycloaddition reaction with a range of organic azides of variable characteristics, we transformed this parent bridged silsesquioxane into new materials with tunable hydrophilic/lipophilic balance in high conversions while preserving the original morphology. N2, cyclohexane, and water sorption experiments were used to quantify the affinity of these materials toward the sorbates through the determination of their Henry's constants. This resulted in the following hydrophilic scale: M-OH > M-PEG > M-C6 > M-Ph > M-F > M-C16, which was mostly confirmed by SWAXS measurements.
authors.affiliation: Institut Charles Gerhardt Montpellier (UMR 5253 CNRS-UM2-ENSCM-UM1), 8, rue de l'école normale, 34296 Montpellier, France.
authors.forename: Achraf
authors.initials: A
authors.lastname: Noureddine
authors.forename: Philippe
authors.initials: P
authors.lastname: Trens
authors.forename: Guillaume
authors.initials: G
authors.lastname: Toquer
authors.forename: Xavier
authors.initials: X
authors.lastname: Cattoën
authors.forename: Michel Wong Chi
authors.initials: MW
authors.lastname: Man
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D057930:Click Chemistry; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D016062:Porosity; D013499:Surface Properties
chemical_list: D000480:Alkynes; D001386:Azides; D017646:Organosilicon Compounds; D003300:Copper