title: Concluding the amyloid formation pathway of a coiled-coil-based peptide from the size of the critical nucleus.
abstract: The size of the critical nucleus acting as intermediate in the amyloid formation of a model peptide is calculated. The theoretical approach is based on experimentally determined amyloid formation rates and gives new insights into the amyloid formation pathway.
authors.affiliation: Department of Chemistry and Biochemistry-Organic Chemistry, Freie Universität Berlin, Takustrasse 3, 14195 Berlin (Germany).
authors.forename: Ulla I M
authors.initials: UI
authors.lastname: Gerling
authors.forename: Markus S
authors.initials: MS
authors.lastname: Miettinen
authors.forename: Beate
authors.initials: B
authors.lastname: Koksch
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D000682:Amyloid; D010455:Peptides
keywords: amyloid formation; coiled coil; nucleus; peptides; theoretical approach