title: [Transdisciplinary Approach for Sarcopenia. The application of life style diseases-animal models to the research for sarcopenia].
abstract: Sarcopenia can be developed based on loss of skeletal muscle mass induced by various age-related factors, and suitable animal models must be needed to elucidate the mechanism of sarcopenia. Since loss of skeletal muscle mass is observed earlier in the elderly with lifestyle-related diseases than in the health elderly, animal models for lifestyle-related diseases can be applicable to the research for sarcopenia. Several reports using animal models for diabetes or specific diet-fed animals show that insulin resistance, hyperglycemia, increase of glucocorticoids, low-grade inflammation and accumulation of advanced glycation end products (AGEs) can accelerate loss of skeletal muscle mass. Thus, the application of these animal models to further investigations on prevention or intervention for sarcopenia will be widely expected.
authors.affiliation: Geriatric Medicine, Osaka University Graduate School of Medicine, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Hiromi
authors.initials: H
authors.lastname: Rakugi
mesh_terms: D000375:Aging; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008019:Life Style; D055948:Sarcopenia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D015398:Signal Transduction