title: Intravenous Zoledronate for a Patient with Paget's Disease.
abstract: Paget's disease (PD) of bone is characterized by increase of bone resorption by atypical osteoclasts, followed by rapid new bone formation resulting in a disorganized mosaic bone. Although the pathophysiology is not fully understood, bisphosphonate, which is a potent anti-resorptive agent for treatment of osteoporosis, have been the most effective agents available for the treatment of PD. We report a case of PD of bone in a 49-year-old woman patient, who was treated with intravenous zoledronate.
authors.affiliation: Department of Orthopedic Surgery, Dankook University School of Medicine, Cheonan, Korea.
authors.forename: Ki-Choul
authors.initials: KC
authors.lastname: Kim
keywords: Bone density conservation agents; Diphosphonates; Osteitis deformans