title: Follow-up of congenital heart disease patients with subclinical hypothyroidism.
abstract: BACKGROUND
  Subclinical hypothyroidism or mild thyroid failure is a common problem in patients without known thyroid disease.
  
  
  METHODS
  Demographic and analytical data were collected in 309, of which 181 were male and 128 were female, congenital heart disease (CHD) patients. CHD patients with thyroid-stimulating hormone above 5.5 mIU/L were also followed up from an analytical point of view to determine changes in serum glucose, cholesterol, N-terminal pro b-type natriuretic peptide, and C-reactive protein concentrations.
  
  
  RESULTS
  Of the CHD patients, 35 (11.3%) showed thyroid-stimulating hormone concentration above 5.5 mIU/L. Of them, 27 were followed up during 2.4±1.2 years - 10 were under thyroid hormone replacement treatment, and 17 were not. Of the 27 patients (25.9%), 7 with subclinical hypothyroidism had positive anti-thyroid peroxidase, and 3 of them (42.8%) with positive anti-thyroid peroxidase had Down syndrome. Down syndrome and hypoxaemic CHD patients showed higher thyroid-stimulating hormone concentrations than the rest of the congenital patients (p<0.001). No significant differences were observed in serum thyroxine, creatinine, uric acid, lipids, C-reactive protein, or N-terminal pro b-type natriuretic peptide concentrations before and after the follow-up in those CHD patients with thyroid-stimulating hormone above 5.5 mIU/L whether or not they received levothyroxine therapy.
  
  
  CONCLUSIONS
  CHD patients with subclinical hypothyroidism showed no significant changes in serum thyroxine, cholesterol, C-reactive protein, or N-terminal pro b-type natriuretic peptide concentrations whether or not they were treated with thyroid hormone replacement therapy.
authors.affiliation: 1Cardiology Service,Complejo Hospitalario Universitario Insular-Materno InfantilLas Palmas de Gran Canaria,Spain.
authors.forename: Efrén
authors.initials: E
authors.lastname: Martínez-Quintana
authors.affiliation: 2Dr Negrín University Hospital of Gran Canaria,Las Palmas de Gran Canaria,Spain.
authors.forename: Fayna
authors.initials: F
authors.lastname: Rodríguez-González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001324:Autoantigens / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000097:blood* / Q000145:classification* / Q000150:complications; D020249:Hormone Replacement Therapy / Q000379:methods; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy*; D007453:Iodide Peroxidase / Q000097:blood*; D033862:Iron-Binding Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D013030:Spain; D013972:Thyrotropin / Q000097:blood*; D055815:Young Adult
chemical_list: D001324:Autoantigens; D033862:Iron-Binding Proteins; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D013972:Thyrotropin; D002097:C-Reactive Protein; C056658:TPO protein, human; D007453:Iodide Peroxidase
keywords: CHD; Subclinical hypothyroidism; follow-up