title: Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase.
abstract: Organocatalysts derived from diethylenetriamine effect the rapid isomerization of non-native protein disulfide bonds to native ones. These catalysts contain a pendant hydrophobic moiety to encourage interaction with the non-native state, and two thiol groups with low pKa values that form a disulfide bond with a high E°' value.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Lukesh
authors.forename: Kristen A
authors.initials: KA
authors.lastname: Andersen
authors.forename: Kelly K
authors.initials: KK
authors.lastname: Wallin
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Raines
mesh_terms: D000818:Animals; D002384:Catalysis; D002417:Cattle; D004220:Disulfides / Q000737:chemistry*; D007536:Isomerism; D007700:Kinetics; D018716:Molecular Mimicry; D010084:Oxidation-Reduction; D010179:Pancreas / Q000737:chemistry / Q000201:enzymology; D011073:Polyamines / Q000737:chemistry*; D011487:Protein Conformation; D019704:Protein Disulfide-Isomerases / Q000737:chemistry*; D017510:Protein Folding; D012259:Ribonuclease, Pancreatic / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis*
chemical_list: D004220:Disulfides; D011073:Polyamines; D054852:Small Molecule Libraries; C005391:diethylenetriamine; D012259:Ribonuclease, Pancreatic; D019704:Protein Disulfide-Isomerases