title: Serum levels of fetuin A are increased in women with gestational diabetes mellitus.
abstract: OBJECTIVE
  Fetuin A is associated with insulin resistance and type 2 diabetes mellitus (DM). We aimed to investigate circulating fetuin A concentrations in gestational diabetes mellitus (GDM).
  
  
  METHODS
  Serum fetuin A levels were studied in 26 pregnant women with GDM and 24 healthy pregnant women between 24th and 28th gestational weeks. Fetuin A levels were also evaluated in 18 of women with GDM at postpartum.
  
  
  RESULTS
  Fetuin A concentrations were significantly increased in women with GDM compared to healthy pregnant women (35.0 ± 3.2 vs. 32.0 ± 4.4 ng/ml; p = 0.01). Also, fetuin A levels in women with GDM significantly decreased at postpartum period (35.0 ± 3.2 vs. 31.7 ± 3.9 ng/ml; p = 0.001). In whole pregnant women, there were positive correlations between fetuin A and HbA1c (r = 0.418, p = 0.002), total cholesterol (r = 0.332, p = 0.018) and triglycerides (r = 0.306, p = 0.031). Multivariate regression analysis demonstrated that HbA1c was the important predictor of circulating fetuin A level (beta = 0.375, p = 0.01).
  
  
  CONCLUSIONS
  In conclusion, our results indicate that serum fetuin A concentrations are increased in women with GDM and decreased after delivery. Therefore, fetuin A might have a role in the development of insulin resistance and the metabolic changes in GDM.
authors.affiliation: Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey, ozturhan78@hotmail.com.
authors.forename: Ozlem Turhan
authors.initials: OT
authors.lastname: Iyidir
authors.forename: Ceyla Konca
authors.initials: CK
authors.lastname: Degertekin
authors.forename: Banu Aktas
authors.initials: BA
authors.lastname: Yilmaz
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.forename: Fusun B
authors.initials: FB
authors.lastname: Toruner
authors.forename: Nuray
authors.initials: N
authors.lastname: Bozkurt
authors.forename: Goksun
authors.initials: G
authors.lastname: Ayvaz
authors.forename: Mujde
authors.initials: M
authors.lastname: Akturk
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D036861:Delivery, Obstetric; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D016640:Diabetes, Gestational / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D060749:alpha-2-HS-Glycoprotein / Q000032:analysis / Q000378:metabolism*
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D060749:alpha-2-HS-Glycoprotein