title: A public health approach to the prevention of inhibitors in hemophilia.
abstract: The development of an antibody in people with hemophilia to products used in the treatment and prevention of bleeding, also referred to as an inhibitor, is the most serious complication of hemophilia care today. CDC, together with healthcare providers, consumer organizations, hemophilia organizations, and federal partners, has developed a public health agenda to prevent the development of inhibitors. This paper describes a public health approach that combines a national surveillance program with epidemiologic, laboratory, and prevention research to address knowledge gaps in rates and risk factors for inhibitor development, and in knowledge and behaviors of patients and providers, in addition to screening and treatment practices.
authors.affiliation: Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia. Electronic address: msoucie@cdc.gov.
authors.forename: J Michael
authors.initials: JM
authors.lastname: Soucie
authors.affiliation: Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia.
authors.forename: Connie H
authors.initials: CH
authors.lastname: Miller
authors.affiliation: Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia.
authors.forename: Fiona M
authors.initials: FM
authors.lastname: Kelly
authors.affiliation: Division of Blood Disorders, National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, Georgia.
authors.forename: Meredith
authors.initials: M
authors.lastname: Oakley
authors.affiliation: University of Texas Health Science Center, MD Anderson Cancer Center and Gulf States Hemophilia and Thrombophilia Treatment Center, Houston, Texas.
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Brown
authors.affiliation: Wayne State University School of Medicine, Detroit, Michigan.
authors.forename: Phillip
authors.initials: P
authors.lastname: Kucab
mesh_terms: D019058:Community Networks; D006467:Hemophilia A / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D011159:Population Surveillance; D011634:Public Health / Q000379:methods; D012307:Risk Factors; D014481:United States / Q000453:epidemiology