title: Protein arginine methyltransferases (PRMTs): role in chromatin organization.
abstract: The mammalian genome encodes eleven protein arginine methyltransferases (PRMTs) that are involved in the transfer of a methyl group from S-adenosylmethionine (AdoMet) to the guanidino nitrogen of arginine. The substrates for these enzymes range from histones to several nuclear and cytoplasmic proteins. Methylation of histones by PRMTs can block the docking site for other reader/effector molecules and thus this modification can interfere with histone code orchestration. Several members of the PRMTs have roles in chromatin organization and function. Although PRMT aberrant expression is correlated with several diseases including cancer, the underlying mechanisms are still obscure in most cases.
authors.affiliation: Manitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba R3E 3P4 Canada.
authors.forename: Sanzida
authors.initials: S
authors.lastname: Jahan
authors.affiliation: Manitoba Institute of Child Health, University of Manitoba, Winnipeg, Manitoba R3E 3P4 Canada. Electronic address: jim.davie@med.umanitoba.ca.
authors.forename: James R
authors.initials: JR
authors.lastname: Davie
mesh_terms: D000818:Animals; D002843:Chromatin / Q000201:enzymology* / Q000235:genetics; D042002:Chromatin Assembly and Disassembly; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D011499:Protein Processing, Post-Translational; D011484:Protein-Arginine N-Methyltransferases / Q000235:genetics / Q000378:metabolism
chemical_list: D002843:Chromatin; D009363:Neoplasm Proteins; D011484:Protein-Arginine N-Methyltransferases
keywords: Chromatin organization; Epigenetics; Histone modifications; Protein arginine methyltransferases