title: Associations between erythrocyte membrane fatty acid compositions and insulin resistance in obese adolescents.
abstract: OBJECTIVE
  Cytokines released from the adipose tissue and fatty acids (FAs) derived from lipolysis or uptake of fats go in to competition with glucose to be uptaken from the liver leads to insulin resistance (IR). We aimed to show the associations among serum lipid profile, FA compositions and IR.
  
  
  METHODS
  Anthropometrical measurements, biochemical parameters and erythrocyte membrane (EM) FA levels of 95 obese adolescents (41 with IR) and 40 healthy controls were compared.
  
  
  RESULTS
  LDL-C, fasting insulin levels, HOMA-IR were significantly higher and HDL-C levels were significantly lower in obese patients than in controls (p=0.013, p<0.001, p<0.001 and p<0.001, respectively). EM C 24:0, C 16:1 ω7 and C 22:1 ω9 FA levels were significantly higher, while C 20:5 ω3 (EPA) levels were significantly lower in obese subjects than in controls (p<0.001, p=0.018, p<0.001, p=0.043 and p<0.001, respectively). Moreover, when obese subjects divided into two groups according to the presence of IR; EM C 16:1 ω7 levels were still significantly higher and EPA levels were still significantly lower in both obese subjects with and without IR compared to controls (p<0.001 for both).
  
  
  CONCLUSIONS
  Saturated FA intake should be decreased because of its role in the development of obesity and IR, and ω-3 group FA intake should be increased.
authors.affiliation: Agri Military Hospital, Department of Pediatrics, Agri, Turkey. Electronic address: dromergunes@gmail.com.
authors.forename: Omer
authors.initials: O
authors.lastname: Gunes
authors.affiliation: Gulhane School of Medicine, Department of Pediatrics, Ankara, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Tascilar
authors.affiliation: Ankara Mevki Military Hospital, Anittepe Dispensary, Ankara, Turkey.
authors.forename: Erdim
authors.initials: E
authors.lastname: Sertoglu
authors.affiliation: Gulhane School of Medicine, Department of Medical Biochemistry, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tas
authors.affiliation: Acıbadem University School Of Medicine, Department of Medical Biochemistry, Istanbul, Turkey.
authors.forename: Muhittin A
authors.initials: MA
authors.lastname: Serdar
authors.affiliation: Gulhane School of Medicine, Department of Pediatrics, Ankara, Turkey.
authors.forename: Güven
authors.initials: G
authors.lastname: Kaya
authors.affiliation: Adana Military Hospital, Department of Medical Biochemistry, Adana, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Kayadibi
authors.affiliation: Gulhane School of Medicine, Department of Pediatrics, Ankara, Turkey.
authors.forename: Okan
authors.initials: O
authors.lastname: Ozcan
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002849:Chromatography, Gas; D004910:Erythrocyte Membrane / Q000737:chemistry*; D005227:Fatty Acids / Q000097:blood*; D015525:Fatty Acids, Omega-3 / Q000097:blood; D043371:Fatty Acids, Omega-6 / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000378:metabolism / Q000473:pathology*; D012372:ROC Curve
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D007328:Insulin
keywords: Adolescent; Eicosapentaenoic acid; Fatty acid; Insulin resistance; Obesity