title: Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats.
abstract: Alcohol-induced oxidative stress plays a crucial role in the pathological development of alcoholic liver disease. The aim of this study was to investigate the effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats. We found that the administration of triterpenoid attenuated alcohol-induced oxidative stress in multiple organs including liver. Moreover, the impaired liver function and histological changes resulted from alcohol consumption was improved by triterpenoid treatment. Finally, we found that pretreatment with triterpenoid from Schisandra chinensis to alcohol-fed rats increased the expression level of haem oxygenase-1 (HO-1) while inhibited the induction of cytochrome P-450 2E1 (CYP2E1) in liver microsomes. Further assays revealed that the microsomal activity of HO-1 was accordingly induced whereas CYP2E1 was suppressed in rats received triterpenoid intervention. Our findings suggest that triterpenoid from Schisandra chinensis may protect against alcohol-induced liver injury through ameliorating oxidative stress in rats.
authors.affiliation: College of Food Science, Shenyang Agricultural University, 120 Dongling Road, Shenyang, 110866, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhu
authors.forename: Ting
authors.initials: T
authors.lastname: Wu
authors.forename: Jiachen
authors.initials: J
authors.lastname: Zhang
authors.forename: Xinyao
authors.initials: X
authors.lastname: Jiao
authors.forename: Xiuying
authors.initials: X
authors.lastname: Liu
authors.forename: Yanqun
authors.initials: Y
authors.lastname: Wang
authors.forename: Xianjun
authors.initials: X
authors.lastname: Meng
mesh_terms: D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000009:adverse effects*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D012333:RNA, Messenger; D014315:Triterpenes; D000431:Ethanol; D019392:Cytochrome P-450 CYP2E1; D051547:Heme Oxygenase-1