title: Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells.
authors.affiliation: Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
authors.forename: Motofumi
authors.initials: M
authors.lastname: Kumazoe
authors.forename: Shuntaro
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Connie
authors.initials: C
authors.lastname: Lesnick
authors.forename: Neil E
authors.initials: NE
authors.lastname: Kay
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Tait D
authors.initials: TD
authors.lastname: Shanafelt
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Tachibana
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D045744:Cell Line, Tumor / Q000187:drug effects; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000378:metabolism; D004354:Drug Screening Assays, Antitumor; D004357:Drug Synergism; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000201:enzymology / Q000473:pathology*; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D058986:Phosphodiesterase 5 Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D017474:Receptors, Laminin / Q000037:antagonists & inhibitors; D012269:Ribosomal Proteins / Q000037:antagonists & inhibitors; D013450:Sulfones / Q000494:pharmacology; D014227:Triazines / Q000494:pharmacology; D000069058:Vardenafil Dihydrochloride
chemical_list: D007093:Imidazoles; D009363:Neoplasm Proteins; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; C510624:RPSA protein, human; D017474:Receptors, Laminin; D012269:Ribosomal Proteins; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride; D002392:Catechin; C045651:epigallocatechin gallate; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5
keywords: 67-kDa laminin receptor; apoptosis; chronic lymphocytic leukaemia; phosphodiesterase 5; protein kinase C delta