title: Functional polysaccharides from Grifola frondosa aqueous extract inhibit atopic dermatitis-like skin lesions in NC/Nga mice.
abstract: Grifola frondosa (GF), distributed widely in far east Asia including Korea, is popularly used as traditional medicines and health supplementary foods, especially for enhancing the immune functions of the body. To extend the application of GF polysaccharides (GFP) for atopic dermatitis (AD), we investigated the effects of GFP on the 2,4-dinitrochlorobenzene-induced AD-like skin lesion in NC/Nga mice. GFP treatment significantly reduced the dorsa skin dermatitis score and combination treatment with GFP, and dexamethasone has a synergistic effect in AD-like skin lesion by reduced Serum IgE, mast cells infiltration, and cytokines expression. These results indicate that GFP suppressed the AD-like skin lesions by controlling the Th-1/Th-2-type cytokines in NC/Nga mice. These findings strongly suggest that GFP can be useful for AD patients as a novel therapeutic agent and might be used for corticosteroids replacement or supplement agent.
authors.affiliation: a Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University , Jinju , Republic of Korea.
authors.forename: Hyeon Soo
authors.initials: HS
authors.lastname: Park
authors.forename: Yong Hyeon
authors.initials: YH
authors.lastname: Hwang
authors.forename: Mun Ki
authors.initials: MK
authors.lastname: Kim
authors.forename: Gyeong Eun
authors.initials: GE
authors.lastname: Hong
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Arulkumar
authors.initials: A
authors.lastname: Nagappan
authors.forename: Silvia
authors.initials: S
authors.lastname: Yumnam
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Kim
authors.forename: Jeong Doo
authors.initials: JD
authors.lastname: Heo
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Chung Kil
authors.initials: CK
authors.lastname: Won
authors.forename: Gon Sup
authors.initials: GS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects; D003876:Dermatitis, Atopic / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D003907:Dexamethasone / Q000494:pharmacology; D004137:Dinitrochlorobenzene; D004357:Drug Synergism; D005260:Female; D048691:Grifola / Q000737:chemistry*; D007073:Immunoglobulin E / Q000097:blood; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D012997:Solvents; D058408:Th1-Th2 Balance / Q000187:drug effects; D014867:Water
chemical_list: D000893:Anti-Inflammatory Agents; D004137:Dinitrochlorobenzene; D010936:Plant Extracts; D011134:Polysaccharides; D012997:Solvents; D014867:Water; D007073:Immunoglobulin E; D003907:Dexamethasone
keywords: Grifola frondosa; Nc/Nga mice; atopic dermatitis; interleukins; polysaccharides