title: Effect of methyl cellulose on gelation behavior and drug release from poloxamer based ophthalmic formulations.
abstract: The effect of weight average molecular weight (Mw) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M(w) by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in Mw of MC. PM with highest Mw of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M(w) of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations.
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Mitali
authors.initials: M
authors.lastname: Dewan
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Biplab
authors.initials: B
authors.lastname: Bhowmick
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Sarkar
authors.affiliation: Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON K1N 6N5, Canada.
authors.forename: Dipak
authors.initials: D
authors.lastname: Rana
authors.affiliation: Contai Polytechnic, Directorate of Technical Education & Training, Contai, East Midnapur, West Bengal-721401, India.
authors.forename: Mrinal Kanti
authors.initials: MK
authors.lastname: Bain
authors.affiliation: Himalayan Pharmacy Institute, Sikkim University, Majhitar, Rangpo, East Sikkim-737136, India.
authors.forename: Manas
authors.initials: M
authors.lastname: Bhowmik
authors.affiliation: Department of Polymer Science and Technology, University College of Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India. Electronic address: dipankar.chattopadhyay@gmail.com.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
mesh_terms: D002626:Chemistry, Pharmaceutical; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D020911:Ketorolac Tromethamine / Q000737:chemistry* / Q000494:pharmacology; D008747:Methylcellulose / Q000737:chemistry / Q000494:pharmacology*; D008970:Molecular Weight; D009883:Ophthalmic Solutions / Q000737:chemistry / Q000494:pharmacology; D020442:Poloxamer / Q000737:chemistry* / Q000494:pharmacology; D012212:Rheology; D013696:Temperature; D014783:Viscosity
chemical_list: D009883:Ophthalmic Solutions; D020442:Poloxamer; D020911:Ketorolac Tromethamine; D008747:Methylcellulose
keywords: Gelation behavior; In vitro drug release; Methyl cellulose; Molecular weight effect; Rheological property