title: The interaction between microglia and neural stem/precursor cells.
abstract: In the adult mammalian brain, neurogenesis from neural stem/precursor cell occurs within two regions, the subgranular zone (SGZ) in the dentate gyrus (DG) and the subventricular zone (SVZ) lining the lateral ventricles. The function of neural stem cell is enhanced by external stimuli, such as injury and inflammation. Microglia, as the main immune modulating cells, play important roles in the central nervous system (CNS). Recently, select discoveries reported that microglia might influence the proliferation, differentiation and survival of neural precursor cells (NPCs). Other studies revealed that NPCs might reversibly regulate the function of microglia. Accordingly, in this review we focus on the interaction between microglia and NPCs.
authors.affiliation: Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Su
authors.affiliation: Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States.
authors.forename: Michael
authors.initials: M
authors.lastname: Aschner
authors.affiliation: Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, China. Electronic address: jy_chen@fmmu.edu.cn.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Occupational & Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, 169 Changlexi Road, Xi'an 710032, China. Electronic address: luowenj@fmmu.edu.cn.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Luo
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D006801:Humans; D017628:Microglia / Q000502:physiology*; D058953:Neural Stem Cells / Q000502:physiology*
keywords: Coculture; Microglia; Neural stem/precursor cells; Neurogenesis