title: [Clinical implication of urinary protein markers in diabetic nephropathy and interventional effects of Chinese herbal medicine].
abstract: In clinic, some urinary protein makers can dynamically and noninvasively reflect the degree of renal tubular injury in patients with diabetic nephropathy (DN). These urinary biomarkers of tubular damage are broadly divided into two categories. One is newfound, including kidney injury molecule-1 (Kim-1), neutrophil getatinase-associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP) and cystatin C (CysC); the other one is classical, including beta2 microglobulin (beta2-MG), retinal binding protein (RBP) and N-acetyl-beta-D-glucosaminidase (NAG). It is reported that, the increases in urinary protein markers are not only closely related to the damage of tubular epithelial cells in DN patients, but also can be ameliorated by the treatment with Chinese herbal compound preparations or Chinese herbal medicine. Recently, although urinary proteomics are used in the protein separation and identification, the traditional associated detection of urinary protein markers is more practical in clinic. At present, it is possible that the associated detection of urinary biomarkers of glomerular and tubular damages may be a feasible measure to reveal the clinical significance of urinary protein markers in DN patients and the interventional effects of Chinese herbal medicine.
authors.forename: Xi-Miao
authors.initials: XM
authors.lastname: Shi
authors.forename: Xian-Jie
authors.initials: XJ
authors.lastname: Meng
authors.forename: Yi-Gang
authors.initials: YG
authors.lastname: Wan
authors.forename: Shan-Mei
authors.initials: SM
authors.lastname: Shen
authors.forename: Xun-Yang
authors.initials: XY
authors.lastname: Luo
authors.forename: Liu-Bao
authors.initials: LB
authors.lastname: Gu
authors.forename: Jian
authors.initials: J
authors.lastname: Yao
mesh_terms: D015415:Biomarkers / Q000652:urine; D003928:Diabetic Nephropathies / Q000150:complications / Q000188:drug therapy* / Q000652:urine*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D011507:Proteinuria / Q000150:complications*
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal