title: What are the latest recommendations for managing severe sepsis and septic shock?
abstract: Severe sepsis is a continuum of physiologic stages characterized by infection, systemic inflammation, and hypoperfusion leading to tissue injury and organ failure. The primary goal of sepsis treatment is to prevent morbidity and mortality. Crystalloids are now recommended over colloids for volume resuscitation, one of the key interventions for patients with sepsis.
authors.affiliation: Christopher M. Bland is a pharmacist in critical care and infectious diseases at Dwight D. Eisenhower Army Medical Center in Fort Gordon, Ga. S. Scott Sutton is an associate professor in the University of South Carolina's South Carolina College of Pharmacy in Columbia, S.C., and a clinical pharmacist in infectious diseases research at the Dorn VA Medical Center in Columbia. Brianne L. Dunn is a clinical assistant professor at South Carolina College of Pharmacy. The authors have disclosed no potential conflicts of interest, financial or otherwise.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Bland
authors.forename: S Scott
authors.initials: SS
authors.lastname: Sutton
authors.forename: Brianne L
authors.initials: BL
authors.lastname: Dunn
mesh_terms: D003102:Colloids / Q000627:therapeutic use; D000077324:Crystalloid Solutions; D006801:Humans; D007552:Isotonic Solutions / Q000627:therapeutic use; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy*; D020246:Venous Thrombosis / Q000517:prevention & control
chemical_list: D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions