title: New insights on food intake control by olfactory processes: the emerging role of the endocannabinoid system.
abstract: The internal state of the organism is an important modulator of perception and behavior. The link between hunger, olfaction and feeding behavior is one of the clearest examples of these connections. At the neurobiological level, olfactory circuits are the targets of several signals (i.e. hormones and nutrients) involved in energy balance. This indicates that olfactory areas are potential sensors of the internal state of the organism. Thus, the aim of this manuscript is to review the literature showing the interplay between metabolic signals in olfactory circuits and its impact on food intake.
authors.affiliation: INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. Electronic address: edgar.soria@inserm.fr.
authors.forename: Edgar
authors.initials: E
authors.lastname: Soria-Gomez
authors.affiliation: Dept. of Biochemistry and Molecular Biology I, Sch. of Biology, Complutense Univ. and CIBERNED, Madrid, Spain.
authors.forename: Luigi
authors.initials: L
authors.lastname: Bellocchio
authors.affiliation: INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Marsicano
mesh_terms: D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000378:metabolism / Q000502:physiology; D004435:Eating; D063388:Endocannabinoids / Q000378:metabolism / Q000502:physiology*; D002149:Energy Intake; D004734:Energy Metabolism; D005247:Feeding Behavior; D005947:Glucose / Q000378:metabolism; D050356:Lipid Metabolism; D008954:Models, Biological; D055696:Olfactory Perception; D012903:Smell
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D005947:Glucose
keywords: Endocannabinoids; Fasting; Feeding behavior; Ghrelin; Leptin; Olfaction