title: Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation.
abstract: Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.
authors.affiliation: Laboratoire Chimie Organique 2 Glycochimie, Université de Lyon, ICBMS, UMR 5246 - CNRS, Université Claude Bernard Lyon 1, Bat. 308 -CPE Lyon, 43 Bd. du 11 Novembre 1918, 69622 Villeurbanne, France. ; Tel: +33-4-72448183 ; Université de Carthage, Faculté des sciences Bizerte, Tunisie.
authors.forename: Meriem
authors.initials: M
authors.lastname: Smadhi
authors.affiliation: Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Institut de Biologie Structurale et Microbiologie, CNRS-Aix Marseille University, UMR7255, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: de Bentzmann
authors.affiliation: Centre de Recherches sur les Macromolécules Végétales (CERMAV), UPR 5301 CNRS et Université Grenoble Alpes, BP53, 38041 Grenoble, France.
authors.forename: Anne
authors.initials: A
authors.lastname: Imberty
authors.affiliation: Aix-Marseille Université, CNRS, CINaM UMR 7325, 163 Avenue de Luminy 13288 Marseille, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Gingras
authors.affiliation: Université de Carthage, Faculté des sciences Bizerte, Tunisie.
authors.forename: Raoudha
authors.initials: R
authors.lastname: Abderrahim
authors.affiliation: Laboratoire Chimie Organique 2 Glycochimie, Université de Lyon, ICBMS, UMR 5246 - CNRS, Université Claude Bernard Lyon 1, Bat. 308 -CPE Lyon, 43 Bd. du 11 Novembre 1918, 69622 Villeurbanne, France. ; Tel: +33-4-72448183.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Goekjian
keywords: antibiotic; biofilm; glycocluster; lectin; multivalency effect; multivalent glycosystems