title: SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation.
abstract: BACKGROUND
  An important inter-individual variability in the response of insulin sensitivity following a fish oil supplementation has been observed. The objective was to examine the associations between single nucleotide polymorphisms (SNPs) within sterol regulatory element binding transcription factor 1 (SREBF1) gene and the response of insulin sensitivity to a fish oil supplementation.
  
  
  METHODS
  Participants (n = 210) were recruited in the greater Quebec City area and followed a 6-week fish oil supplementation protocol (5 g/day: 1.9-2.2 g EPA; 1.1 g DHA). Insulin sensitivity was assessed by the quantitative insulin sensitivity check index (QUICKI). Three tag SNPs (tSNPs) within SREBF1 gene were genotyped according to TAQMAN methodology.
  
  
  RESULTS
  Three tSNPs (rs12953299, rs4925118 and rs4925115) covered 100% of the known genetic variability within SREBF1 gene. None of the three tSNPs was associated with either baseline fasting insulin concentrations (rs12953299, rs4925118 and rs4925115) (p = 0.29, p = 0.20 and p = 0.70, respectively) or QUICKI (p = 0.20, p = 0.18 and p = 0.76, respectively). The three tSNPs (rs12953299, rs4925118 and rs4925115) were associated with differences in the response of plasma insulin levels (p = 0.01, p = 0.005 and p = 0.004, respectively) and rs12953299 as well as rs4925115 were associated with the insulin sensitivity response (p = 0.009 and p = 0.01, respectively) to the fish oil supplementation, independently of the effects of age, sex and BMI.
  
  
  CONCLUSIONS
  The genetic variability within SREBF1 gene has an impact on the insulin sensitivity in response to a fish oil supplementation.
  
  
  BACKGROUND
  clinicaltrials.gov: NCT01343342.
authors.forename: Annie
authors.initials: A
authors.lastname: Bouchard-Mercier
authors.forename: Iwona
authors.initials: I
authors.lastname: Rudkowska
authors.forename: Simone
authors.initials: S
authors.lastname: Lemieux
authors.forename: Patrick
authors.initials: P
authors.lastname: Couture
authors.forename: Louis
authors.initials: L
authors.lastname: Pérusse
authors.affiliation: Institute of Nutrition and Functional Foods (INAF), Laval University, 2440 Hochelaga Blvd,, Quebec G1V 0A6, Canada. marie-claude.vohl@fsaa.ulaval.ca.
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Vohl
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose; D019587:Dietary Supplements; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005395:Fish Oils / Q000008:administration & dosage*; D015870:Gene Expression; D059647:Gene-Environment Interaction; D056726:Genetic Association Studies; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D020641:Polymorphism, Single Nucleotide; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D005395:Fish Oils; D007328:Insulin; D010743:Phospholipids; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1