title: A lysosome-targeted fluorescent chemodosimeter for monitoring endogenous and exogenous hydrogen sulfide by in vivo imaging.
abstract: A lysosome-targeted fluorescent chemodosimeter, 1, was developed for monitoring endogenous and exogenous H2S by in vivo imaging of HeLa cells, D. melanogaster and C. elegans. In the tests of mutated C. elegans (SRP-6 nulls), chemodosimeter 1 could trace the accumulation of lysosome and lysosomal injury with a high resolution.
authors.affiliation: College of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China. yingzhou@ynu.edu.cn.
authors.forename: Xiao Ju
authors.initials: XJ
authors.lastname: Zou
authors.forename: Yi Cheng
authors.initials: YC
authors.lastname: Ma
authors.forename: Lin E
authors.initials: LE
authors.lastname: Guo
authors.forename: Wen Xiang
authors.initials: WX
authors.lastname: Liu
authors.forename: Mei Juan
authors.initials: MJ
authors.lastname: Liu
authors.forename: Cheng Gang
authors.initials: CG
authors.lastname: Zou
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jun Feng
authors.initials: JF
authors.lastname: Zhang
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000378:metabolism*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D061848:Optical Imaging
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D006862:Hydrogen Sulfide