title: Accuracy of positron emission tomography and positron emission tomography-CT in the detection of differentiated thyroid cancer recurrence with negative (131) I whole-body scan results: A meta-analysis.
abstract: BACKGROUND
  The purpose of this review was to present a meta-analysis aimed to evaluate the accuracy of positron emission tomography (PET) and PET-CT for detecting recurrence of differentiated thyroid carcinoma (DTC) not identified by (131) I whole-body scintigraphy.
  
  
  METHODS
  MEDLINE, EMBASE, LILACS, and Cochrane databases were searched for studies published between January 1985 and March 2012. Systematic methods were used to select and evaluate the quality of studies. Pooled sensitivity and specificity for conventional PET and PET-CT was estimated using random effects model.
  
  
  RESULTS
  Twenty studies were included in the systematic review; the data of 18 studies were used in the meta-analysis. The combined sensitivity and specificity for conventional PET were both found to be 84%; for PET-CT, they were 93% and 81%, respectively. The overall accuracies were 91% and 93%, respectively.
  
  
  CONCLUSIONS
  (18) Fluorodeoxyglucose (FDG)-PET and PET-CT are highly accurate diagnostics tools for DTC recurrence in patients who present a negative whole-body scintigraphy and could impact the clinical and therapeutic management of DTC.
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.
authors.forename: Rosângela
authors.initials: R
authors.lastname: Caetano
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.|Regional Council of Pharmacy of the State of Rio de Janeiro (Conselho Regional de Farmácia do Estado do Rio de Janeiro - CRF-RJ), Rio de Janeiro, Brazil.
authors.forename: Cláudia Regina Garcia
authors.initials: CR
authors.lastname: Bastos
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.|Severino Sombra University (Universidade Severino Sombra), Rio de Janeiro, Brazil.
authors.forename: Ione Ayala Gualandi
authors.initials: IA
authors.lastname: de Oliveira
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.|Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation (Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz), Rio de Janeiro, Brazil.
authors.forename: Rondineli Mendes
authors.initials: RM
authors.lastname: da Silva
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.
authors.forename: Clarisse Pereira Dias Drumond
authors.initials: CP
authors.lastname: Fortes
authors.affiliation: Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation (Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz), Rio de Janeiro, Brazil.
authors.forename: Vera Lucia Edais
authors.initials: VL
authors.lastname: Pepe
authors.affiliation: Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation (Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz), Rio de Janeiro, Brazil.
authors.forename: Lenice Gnocchi
authors.initials: LG
authors.lastname: Reis
authors.affiliation: Institute of Social Medicine, State University of Rio de Janeiro (Universidade do Estado do Rio de Janeiro - UERJ), Rio de Janeiro, Brazil.|Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation (Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz), Rio de Janeiro, Brazil.
authors.forename: José Ueleres
authors.initials: JU
authors.lastname: Braga
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes; D064847:Multimodal Imaging; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET); differentiated thyroid carcinoma; meta-analysis; negative radioiodine whole-body scan; thyroid cancer