title: Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties.
abstract: The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Kinga
authors.initials: K
authors.lastname: Lancz
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Lubica
authors.initials: L
authors.lastname: Murínová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Henrieta
authors.initials: H
authors.lastname: Patayová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Beata
authors.initials: B
authors.lastname: Drobná
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Soňa
authors.initials: S
authors.lastname: Wimmerová
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Eva
authors.initials: E
authors.lastname: Sovčíková
authors.affiliation: Department of Stomatology and Maxillofacial Surgery, Comenius University, Faculty of Medicine in Bratislava, Špitálska 24, 813 72 Bratislava, Slovakia.
authors.forename: Ján
authors.initials: J
authors.lastname: Kováč
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia.
authors.forename: Dana
authors.initials: D
authors.lastname: Farkašová
authors.affiliation: Division of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California Davis, One Shields Avenue, Med-Sci 1C, Davis, CA, USA.
authors.forename: Irva
authors.initials: I
authors.lastname: Hertz-Picciotto
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Blvd, CU 420644, Rochester, NY 14642, USA.
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.affiliation: Slovak Medical University, Limbová 14, 83303 Bratislava, Slovakia. Electronic address: tomas.trnovec@szu.sk.
authors.forename: Tomáš
authors.initials: T
authors.lastname: Trnovec
mesh_terms: D001692:Biological Transport; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D050356:Lipid Metabolism; D008431:Maternal-Fetal Exchange; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011247:Pregnancy; D012044:Regression Analysis; D018154:Slovakia
chemical_list: D011078:Polychlorinated Biphenyls
keywords: Partition coefficient octanol water; Physicochemical parameters; Placenta; Placental transfer; Polychlorinated biphenyls