title: Short-term kinetics of torque teno virus viraemia after induction immunosuppression confirm T lymphocytes as the main replication-competent cells.
abstract: Torque teno virus (TTV) is increasingly considered a universal marker of global immune function. The virus is supposed to replicate in lymphocytes, but poor information is available about fluctuations of viraemia after administration of anti-lymphocyte agents. We studied TTV kinetics in a cohort of 70 kidney±pancreas recipients receiving one of two different anti-T-cell induction immunosuppressants. During the first 30 days after anti-T-cell antibody administration, we report kinetics of TTV viraemia compatible with replication in T lymphocytes, and highly dependent on the potency of the anti-T-cell drug administered.
authors.affiliation: Virology Unit, Pisa University Hospital, Pisa, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Focosi
authors.affiliation: Department of Biomedical Sciences, Clinical Microbiology and Virology Unit, University of Cagliari Medical School, Cagliari, Italy.|Virology Unit, Pisa University Hospital, Pisa, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Macera
authors.affiliation: Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.
authors.forename: Ugo
authors.initials: U
authors.lastname: Boggi
authors.affiliation: Virology Unit, Pisa University Hospital, Pisa, Italy.
authors.forename: Luca Ceccherini
authors.initials: LC
authors.lastname: Nelli
authors.affiliation: Virology Unit, Pisa University Hospital, Pisa, Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Maggi
mesh_terms: D000961:Antilymphocyte Serum / Q000276:immunology*; D004261:DNA Replication / Q000235:genetics* / Q000276:immunology; D004266:DNA Virus Infections / Q000276:immunology / Q000821:virology; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*; D007700:Kinetics; D013601:T-Lymphocytes / Q000276:immunology* / Q000821:virology; D022783:Torque teno virus / Q000235:genetics* / Q000276:immunology*; D014766:Viremia / Q000276:immunology* / Q000821:virology
chemical_list: D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents