title: Increase of peripheral blood CD57+ T-cells in patients with oral squamous cell carcinoma.
abstract: OBJECTIVE
  The subset of T-cells positive for expression of cluster of differentiation (CD) 57 has been associated with various cancer phenotypes. However, the presence of CD57(+) T-cells in patients with oral squamous cell carcinoma (OSCC) has yet to be confirmed. In the present study, we examined the diagnostic significance of the presence of CD57(+) T-cells in peripheral blood (PB) from patients with OSCC.
  
  
  METHODS
  The subset of CD57(+) T-cells in PB was analyzed in 43 patients with OSCC by fluorescence-activated cell sorting (FACS) analysis.
  
  
  RESULTS
  The proportion of CD57(+) T-cells, including both CD8(+) and CD4(+) subsets, significantly increased with clinical stage, especially in parallel with tumor size.
  
  
  CONCLUSIONS
  Our results suggest that an increase in the population of CD57(+) T-cells is a potent prognostic marker and may also influence the systemic immunity of patients with OSCC.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Iida
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Takayama
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Kosuke
authors.initials: K
authors.lastname: Naganawa
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Mitsudo
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Adachi
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Baba
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Fujimoto-Muto
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Motohashi
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Mizuno-Kamiya
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Harumi
authors.initials: H
authors.lastname: Kawaki
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Mitomu
authors.initials: M
authors.lastname: Kioi
authors.affiliation: Second Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Ichinose
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Sumitomo
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Muramatsu
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, Mizuho, Gifu, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Shikimori
authors.affiliation: Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
authors.forename: Iwai
authors.initials: I
authors.lastname: Tohnai
authors.affiliation: Department of Oral Biochemistry, School of Dentistry, Asahi University, Mizuho, Gifu, Japan nkondoh@dent.asahi-u.ac.jp.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kondoh
mesh_terms: D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism; D018959:CD57 Antigens / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000097:blood* / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D047368:Tumor Burden
chemical_list: D000954:Antigens, Surface; D018959:CD57 Antigens
keywords: CD57; Oral squamous cell carcinoma; T-cells; peripheral blood