title: A systematic review and meta-analysis of randomized controlled trials comparing interventions for peristomal skin care.
abstract: Standard skin care procedures for percutaneous endoscopic gastrostomy (PEG) tubes and peristomal skin care for colostomy and ileostomy patients are not always sufficient to prevent peristomal skin problems. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare the effectiveness of standard peristomal skin care to adjunctive techniques or barriers (including glycogel dressings, gelatin- and pectin-based skin barriers, glycerin hydrogel wound dressing, Acacia senegal fiber pockets, hydrocolloid powder crusting, and German chamomile) to manage or treat patients with a stoma. Using systematic literature search techniques, all healthcare databases were searched up through September 2014. No language restrictions were applied. Studies were included if they met criteria for published RCTs or quasi-RCTs that evaluated the outcome of standardized peristomal skin care and other adjunctive techniques or barriers used among patients with a stoma or PEG tube. A meta-analysis was performed to calculate a pooled effect size by using random-effect models for the primary (skin irritation/reaction) and secondary (length of pouch wear time) outcomes. Six RCTs comprising 418 total patients were identified. Four evaluated the outcome of colostomy or ileostomy peristomal skin care, and no significant differences were detected in the incidence of skin problems (RR 0.67; 95% CI: 0.31-1.41). In the two studies that included length of pouch wear time, no significant differences were observed (RR 0.48; 95% CI: 0.03-7.97). No significant differences were seen in the rate of skin irritations of gastrostomy patients (RR 0.56; 95% CI: 0.20-1.59), but the difference in treatment outcomes of peristomal damage in patients with a colostomy was significant (P = 0.01). The limited number of studies, study quality, heterogeneity of variability in peristomal care strategies and techniques, clinical factors, and nonuniform reporting of clinical parameters contributed to the heterogeneity among the trials. Well-designed RCTs are needed to investigate the efficacy of various barriers and techniques for peristomal skin care and to help develop evidence-based standards of caring for the skin of patients with a colostomy, ileostomy, or gastrostomy.
authors.affiliation: Taipei Medical University, Taipei, Taiwan; and Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
authors.forename: Ka-Wai
authors.initials: KW
authors.lastname: Tam
authors.affiliation: HungKuang University, Taichung City, Taiwan and Erlin Branch of Changhua Christian Hospital, Changhua City, Taiwan.
authors.forename: Jun-Hung
authors.initials: JH
authors.lastname: Lai
authors.affiliation: Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
authors.forename: Hung-Chou
authors.initials: HC
authors.lastname: Chen
authors.affiliation: Taipei Medical University, Taipei, Taiwan.
authors.forename: Wen-Hsuan
authors.initials: WH
authors.lastname: Hou
authors.affiliation: HungKuang University, Taichung City, Taiwan.
authors.forename: Wang-Sheng
authors.initials: WS
authors.lastname: Ko
authors.affiliation: HungKuang University, Taichung City, Taiwan.
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Chen
authors.affiliation: HungKuang University, Taichung City, Taiwan; email:email: m8706001@gmail.com.
authors.forename: Tsai-Wei
authors.initials: TW
authors.lastname: Huang
mesh_terms: D003125:Colostomy / Q000592:standards* / Q000639:trends; D006801:Humans; D007081:Ileostomy / Q000592:standards* / Q000639:trends; D016032:Randomized Controlled Trials as Topic; D017592:Skin Care / Q000379:methods*; D013812:Therapeutics / Q000379:methods / Q000592:standards; D016896:Treatment Outcome