title: Intestinal colonization by a Lachnospiraceae bacterium contributes to the development of diabetes in obese mice.
abstract: The aim of the present study was to identify bacteria that may contribute to the onset of metabolic dysfunctions. We isolated and identified a candidate bacterium belonging to Lachnospiraceae (strain AJ110941) in the feces of hyperglycemic obese mice. The colonization of germ-free ob/ob mice by AJ110941 induced significant increases in fasting blood glucose levels as well as liver and mesenteric adipose tissue weights, and decreases in plasma insulin levels and HOMA-β values. These results indicated that the specific gut commensal bacterium AJ110941 influenced the development of obesity and diabetes in ob/ob mice with genetic susceptibility for obesity.
authors.affiliation: Institute for Innovation, Ajinomoto Co., Inc.
authors.forename: Keishi
authors.initials: K
authors.lastname: Kameyama
authors.forename: Kikuji
authors.initials: K
authors.lastname: Itoh
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D000068016:Eubacteriales / Q000254:growth & development*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D003920:Diabetes Mellitus / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D016908:Gram-Positive Bacterial Infections / Q000150:complications*; D007328:Insulin / Q000097:blood; D008099:Liver / Q000473:pathology; D008643:Mesentery / Q000473:pathology; D008820:Mice, Obese; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA
chemical_list: D001786:Blood Glucose; D004269:DNA, Bacterial; D007328:Insulin