title: Membrane-spanning DNA nanopores with cytotoxic effect.
abstract: DNA-based cytotoxic agents: Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and kill cancer cells. The mode by which the pores achieve cell killing is elucidated with confocal microscopy.
authors.affiliation: Department of Chemistry, University College London, Institute of Structural and Molecular Biology, 20 Gordon Street, London WC1H OAJ (UK).
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Burns
authors.forename: Noura
authors.initials: N
authors.lastname: Al-Juffali
authors.forename: Sam M
authors.initials: SM
authors.lastname: Janes
authors.forename: Stefan
authors.initials: S
authors.lastname: Howorka
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects; D003603:Cytotoxins / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D058608:Nanopores / Q000648:ultrastructure*; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003603:Cytotoxins; D004247:DNA
keywords: DNA origami; cancer; cells; nanopores; nucleic acids