title: An overview on biologic medications and their possible role in apical periodontitis.
abstract: BACKGROUND
  Apical periodontitis (AP) is the expression of a deficient balance between infection and the host immune response.
  
  
  METHODS
  If reducing the bacterial load from the root canal and preventing its reinfection may lead to clinical success, then the integrity of the nonspecific immune system has a relevant influence on the outcome of endodontic treatment.
  
  
  RESULTS
  Compromised immune systems and/or genetic alterations of the host's response may as well play an important role on the development, progression, and healing of AP. Thus, immunomodulatory drugs might have the potential to influence both the severity of AP and the outcome of endodontic treatment. Biologic medications are a new class of drugs of monoclonal antibodies or fusion proteins that include fragments of a peculiar cytokine receptor. Specific inflammatory molecules or cells, such as tumor necrosis factor, interleukins, and T or B cells, are the selective targets of these drugs. They modulate the altered immune response and perform an important role in the short-term treatment of chronic inflammatory diseases such as rheumatoid arthritis, refractory Crohn disease, or ulcerative colitis. Despite the clinical positive outcomes and their widespread use, the consequences of administering biologic medications on the development of the dental diseases have not been adequately investigated.
  
  
  CONCLUSIONS
  The aim of this review was to give an overview of biologic medications, their composition, their mechanisms of action, and their possible implications on endodontic and other dental diseases.
authors.affiliation: Department of Conservative Dentistry and Endodontics, School of Dentistry, University of Cagliari, Italy. Electronic address: cottiend@tin.it.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cotti
authors.affiliation: Department of Conservative Dentistry and Endodontics, School of Dentistry, University of Cagliari, Italy; Department of Endodontology, Kings College Dental Institute, London, United Kingdom.
authors.forename: Elia
authors.initials: E
authors.lastname: Schirru
authors.affiliation: Department of Life and Environmental Sciences, School of Pharmacology, University of Cagliari, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Acquas
authors.affiliation: Department of Gastroenterology, School of Medicine, University of Cagliari, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Usai
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007155:Immunologic Factors / Q000627:therapeutic use*; D010485:Periapical Periodontitis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D012390:Root Canal Therapy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D007155:Immunologic Factors
keywords: Apical periodontitis; biologic drugs