title: Overexpression of reactive oxygen species scavenger enzymes is associated with a good prognosis in triple-negative breast cancer.
abstract: OBJECTIVE
  The aim of this study was to investigate the expression of redox proteins in triple-negative breast cancer (TNBC), a breast cancer type which harbors an aggressive phenotype, and to demonstrate the relationships between the expression of reactive oxygen species (ROS) markers and clinical outcome.
  
  
  METHODS
  From 2000 to 2005, we analyzed tissue samples from 135 cases of TNBC obtained from curative surgeries at the Severance Hospital, Seoul, South Korea. Immunochemical staining for redox proteins was performed.
  
  
  RESULTS
  The median patient age was 48 (range 27-76) years. TNM staging was as follows: T1 (n = 52, 38.5%), T2 (n = 81, 60%), T3 (n = 2, 1.5%), N0 (n = 88, 65.2%), N1 (n = 35, 25.9%), N2 (n = 8, 5.9%) and N3 (n = 4, 3.0%). Median follow-up was 59 (range 12-99) months. The high-expression catalase group tended to have a lower N stage (p = 0.016), lower tumor recurrence (p = 0.02) as well as longer overall survival rates (p = 0.05). After adjusting for patient age as well as tumor and nodal stage, we found that primary breast cancers with high catalase expression levels did not have an improved clinical outcome. A high MTC4 expression in the stroma was strongly associated with increased manganese superoxide dismutase expression (p = 0.015) and a significantly longer overall survival (p = 0.032).
  
  
  CONCLUSIONS
  Considering the lack of targeted molecules as well as molecular heterogeneity of TNBC, ROS markers may provide clues to clinical outcome in TNBC.
authors.affiliation: Division of Medical Oncology, Department of Internal Medicine, Yonsei University Medical College, Seoul, Republic of Korea.
authors.forename: Darae
authors.initials: D
authors.lastname: Kim
authors.forename: Ja Seung
authors.initials: JS
authors.lastname: Koo
authors.forename: Soohyeon
authors.initials: S
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D002374:Catalase / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D027501:Monocarboxylic Acid Transporters / Q000032:analysis; D009124:Muscle Proteins / Q000032:analysis; D009367:Neoplasm Staging; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000032:analysis; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology
chemical_list: D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; D017382:Reactive Oxygen Species; C406962:SLC16A4 protein, human; D002374:Catalase; D013482:Superoxide Dismutase