title: When noise makes music: HIV reactivation with transcriptional noise enhancers.
abstract: Reactivating latent HIV is key to depleting the virus reservoir in AIDS patients. A recent paper has described the rationale for and discovery of a new class of drugs - transcriptional noise enhancers - that can synergize with conventional transcription activators to more effectively reactivate latently infected T cells. As well as describing a promising new strategy in the bid to find a cure for AIDS, this study more broadly highlights the utility of exploring drug combinations in treatment of human disease.
authors.affiliation: School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084 China.
authors.forename: Xu
authors.initials: X
authors.lastname: Tan
authors.affiliation: Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Boston, MA 02115 USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Elledge