title: ViRBase: a resource for virus-host ncRNA-associated interactions.
abstract: Increasing evidence reveals that diverse non-coding RNAs (ncRNAs) play critically important roles in viral infection. Viruses can use diverse ncRNAs to manipulate both cellular and viral gene expression to establish a host environment conducive to the completion of the viral life cycle. Many host cellular ncRNAs can also directly or indirectly influence viral replication and even target virus genomes. ViRBase (http://www.rna-society.org/virbase) aims to provide the scientific community with a resource for efficient browsing and visualization of virus-host ncRNA-associated interactions and interaction networks in viral infection. The current version of ViRBase documents more than 12,000 viral and cellular ncRNA-associated virus-virus, virus-host, host-virus and host-host interactions involving more than 460 non-redundant ncRNAs and 4400 protein-coding genes from between more than 60 viruses and 20 hosts. Users can query, browse and manipulate these virus-host ncRNA-associated interactions. ViRBase will be of help in uncovering the generic organizing principles of cellular virus-host ncRNA-associated interaction networks in viral infection.
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Peking University Health Science Center, Beijing, China.
authors.forename: Yanhui
authors.initials: Y
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Changliang
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Zhengqiang
authors.initials: Z
authors.lastname: Miao
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Xiaoman
authors.initials: X
authors.lastname: Bi
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Deng
authors.initials: D
authors.lastname: Wu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Nana
authors.initials: N
authors.lastname: Jin
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Qian
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Chunhua
authors.initials: C
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Chunrui
authors.initials: C
authors.lastname: Zhang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yi
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Lai
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Computer Science and Engineering, The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Kwong-Sak
authors.initials: KS
authors.lastname: Leung
authors.affiliation: Department of Pathology, Harbin Medical University, Harbin, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Microbiology, Harbin Medical University, Harbin, China.
authors.forename: Fengmin
authors.initials: F
authors.lastname: Zhang
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China wangdong@ems.hrbmu.edu.cn.
authors.forename: Kongning
authors.initials: K
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China wangdong@ems.hrbmu.edu.cn.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China wangdong@ems.hrbmu.edu.cn.
authors.forename: Dong
authors.identifier: http://orcid.org/0000-0001-7949-5285
authors.initials: D
authors.lastname: Wang
mesh_terms: D001665:Binding Sites; D030541:Databases, Genetic; D020407:Internet; D011506:Proteins / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism*; D014777:Virus Diseases / Q000235:genetics* / Q000378:metabolism / Q000821:virology*; D014780:Viruses / Q000378:metabolism
chemical_list: D011506:Proteins; D022661:RNA, Untranslated