title: Triglyceride levels are closely associated with mild declines in estimated glomerular filtration rates in middle-aged and elderly Chinese with normal serum lipid levels.
abstract: OBJECTIVE
  To investigate the relationship between lipid profiles [including total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] and a mild decline in the estimated glomerular filtration rate (eGFR) in subjects with normal serum lipid levels.
  
  
  METHODS
  In this study, we included 2647 participants who were ≥ 40 years old and had normal serum lipid levels. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation was used to estimate the GFR. A mildly reduced eGFR was defined as 60-90 mL/min/1.73 m(2). First, multiple linear regression analysis was used to estimate the association of lipid profiles with the eGFR. Then, the levels of each lipid component were divided into four groups, using the 25th, 50th and 75th percentiles as cut-off points. Finally, multiple logistic regression analysis was used to investigate the association of different lipid components with the risk of mildly reduced eGFR.
  
  
  RESULTS
  In the group with a mildly reduced eGFR, TG and LDL-C levels were significantly increased, but HDL-C levels were significantly decreased. After adjusting for age, gender, body mass index (BMI), systolic blood pressure (SBP), glycated hemoglobin (HbA1c), smoking and drinking, only TC and TG were independently related to the eGFR. Additionally, only TG showed a linear relationship with an increased risk of a mildly reduced eGFR, with the highest quartile group (TG: 108-150 mg/dl [1.22-1.70 mmol/L]) having a significantly increased risk after adjusting for the above factors.
  
  
  CONCLUSIONS
  Triglyceride levels are closely associated with a mildly reduced eGFR in subjects with normal serum lipid levels. Dyslipidemia with lower TG levels could be used as new diagnostic criteria for subjects with mildly reduced renal function.
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Shantui Community Health Center, Jining, Shandong, China.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Shantui Community Health Center, Jining, Shandong, China.
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, Second People's Hospital of Jining, Jining, Shandong, China.
authors.forename: Yulian
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Second People's Hospital of Jining, Jining, Shandong, China.
authors.forename: Chengqiao
authors.initials: C
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Second People's Hospital of Jining, Jining, Shandong, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.affiliation: Lukang Hospital of Jining, Jining, Shandong, China.
authors.forename: Shaoyuan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Lukang Hospital of Jining, Jining, Shandong, China.
authors.forename: Weifang
authors.initials: W
authors.lastname: Yang
authors.affiliation: China National Heavy Duty Truck Group Corporation Hospital, Jinan, Shandong, China.
authors.forename: Zeqiang
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Aixia
authors.initials: A
authors.lastname: Ma
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Huizhen
authors.initials: H
authors.lastname: Zheng
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Wu
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Liang
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gong
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Meijian
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yan
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Junpeng
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Lingshu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Tian
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Jidong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Ruxing
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology, the Second Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Shihong
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University, Jinan, Shandong, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood* / Q000502:physiology*; D044466:Asian People; D002681:China; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides