title: [Whether fibrinogen concentrates are necessary in Russia?].
abstract: OBJECTIVE
  To analyze an efficiency of hypofibrinogenemia treatment. In the Scientific Center for Hematology (Moscow) significant hypofibrinogenemia occurs in 3% of patients with hemoblastosis. 1000 doses of cryoprecipitate are used for a hypofibrinogenemia treatment every year (21-23 doses for each patient). Containing of fibrinogen in a one cryoprecipitate dose is from 108 mug to 711 mug (M = 276 mug). Volume of one dose is from 8 to 90 ml (M = 24 ml). Hypofibrinogenemia occurred in all patients required a cryoprecipitate transfusion (M = 1 g L(-1), min 0.5 g L(-1), max 2 g L(-1)). We fixed an increasing of fibrinogen level in plasma by 0.7 +/- 0.2 g L(-1) after the cryoprecipitate transfusion. We analyzed a world experience of the use of fibrinogen containing blood components.
  
  
  CONCLUSIONS
  Fresh frozen plasma transfusion cannot be a choice method of treatment for hypofibrinogenemia. Fibrinogen's concentrate has the same effectiveness as a cryoprecipitate both for congenital and acquired deficit of fibrinogen. The frequency of complications due to fibrinogen's concentrate is low. Currently clinical studies of recombinant fibrinogen are conducted. Ways of implementation of fibrinogen preparations in Russia are discussed.
authors.forename: G M
authors.initials: GM
authors.lastname: Galstian
authors.forename: A L
authors.initials: AL
authors.lastname: Berkovskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Zhuravlev
authors.forename: D M
authors.initials: DM
authors.lastname: Polokhov
authors.forename: V G
authors.initials: VG
authors.lastname: Savchenko
mesh_terms: D000347:Afibrinogenemia / Q000097:blood / Q000209:etiology / Q000628:therapy*; D016913:Blood Component Transfusion / Q000379:methods*; D005169:Factor VIII / Q000008:administration & dosage* / Q000032:analysis; D005340:Fibrinogen / Q000008:administration & dosage* / Q000032:analysis; D006801:Humans; D017410:Practice Guidelines as Topic; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012426:Russia
chemical_list: D011994:Recombinant Proteins; C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005340:Fibrinogen