title: An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate.
abstract: The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2'-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.
authors.affiliation: Department of Chemistry, University of Gdansk, 80-308 Gdansk, Poland. janusz.rak@ug.edu.pl.
authors.forename: Lidia
authors.initials: L
authors.lastname: Chomicz
authors.forename: Alex
authors.initials: A
authors.lastname: Petrovici
authors.forename: Ian
authors.initials: I
authors.lastname: Archbold
authors.forename: Amitava
authors.initials: A
authors.lastname: Adhikary
authors.forename: Anil
authors.initials: A
authors.lastname: Kumar
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sevilla
authors.forename: Janusz
authors.initials: J
authors.lastname: Rak
mesh_terms: D003857:Deoxyuridine / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry*; D015394:Molecular Structure; D011789:Quantum Theory; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D005609:Free Radicals; D014867:Water; D017665:Hydroxyl Radical; D003857:Deoxyuridine