title: A water-soluble calix[4]arene-based ligand for the selective linear coordination and stabilization of copper(I) ion in aerobic conditions.
abstract: A number of serious diseases are linked to copper homeostasis dysfunction. The design of copper(I)-selective chelators is of particular interest not only for the creation of therapeutic objects but also as useful tools to gain insights into the coordination of copper(I) in a biological medium. A water-soluble Cu(I)-selective ligand that associates strong Cu(I) binding at pH = 7.4 (10(14) M(-1)), insensitivity to air, and selectivity toward Cu(II) and other biologically relevant cations is described.
authors.affiliation: Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, CNRS UMR 8601, Université Sorbonne Paris Cité, Université Paris Descartes , 45 rue des Saints Pères, 75006 Paris, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Maurin
authors.forename: Sambika
authors.initials: S
authors.lastname: Varatharajan
authors.forename: Benoit
authors.initials: B
authors.lastname: Colasson
authors.forename: Olivia
authors.initials: O
authors.lastname: Reinaud