title: Catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol via intramolecular interception of alkyl azides with diazo(aryl)acetates.
abstract: The first catalytic enantioselective desymmetrization of 1,3-diazido-2-propanol via an intramolecular interception of alkyl azides by Cu-carbenoids has been realized. A wide range of 1,3-diazidoisopropyl diazo(aryl)acetates were converted to cyclic α-imino esters in the presence of bisoxazoline ligand (S,S)-Ph-Box with good to excellent yields, and the enantiomeric excess was up to 97%.
authors.affiliation: Key Laboratory of Energy Sources & Engineering, State Key Laboratory Cultivation Base of Natural Gas Conversion and Department of Chemistry, Ningxia University , Yinchuan 750021, China.
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Su
authors.forename: Peiming
authors.initials: P
authors.lastname: Gu