title: Low-grade temporal gliomas: surgical strategy and long-term seizure outcome.
abstract: Low-grade gliomas (LGGs) are generally located in temporal lobe and cause medically-intractable seizure so that surgical treatment becomes inevitable. This study includes a retrospective analysis of our patients with temporal LGGs retrieved from our epilepsy surgery data base and tries to present appropriate surgical approach and long-term seizure and anti-epileptic drug (AED) outcomes. Fifty-three patients including children and adults underwent surgery on temporal lobe LGGs and 35 patients were reached to report seizure and AED outcomes. On the non-dominant temporal lobe, anterior temporal resection with hippocampectomy whether mesial structure are involved or not is the appropriate approach. On the dominant temporal lobe mesial structures should be respected. However, total resection of the tumor should be the goal of surgery. Mean follow-up period was 8.3 years and favorable seizure outcome was found to be 91.4%. Surgery decreased AED usage and mean number of AED significantly decreased. Children also benefited from surgery as adults. Surgical treatment of tumor-related epilepsy from temporal lobe controls seizures, and total removal should be the main goal of surgery as neuropsychological testing permit.
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Rahsan
authors.initials: R
authors.lastname: Kemerdere
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Odhan
authors.initials: O
authors.lastname: Yuksel
authors.affiliation: Department of Neurosurgery, Sakarya University, Sakarya, Turkey.
authors.forename: Tibet
authors.initials: T
authors.lastname: Kacira
authors.affiliation: Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Naz
authors.initials: N
authors.lastname: Yeni
authors.affiliation: Department of Neurology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Cigdem
authors.initials: C
authors.lastname: Ozkara
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address: tanerato2000@yahoo.com.
authors.forename: Taner
authors.initials: T
authors.lastname: Tanriverdi
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uzan
authors.affiliation: Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Emin
authors.initials: E
authors.lastname: Ozyurt
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000150:complications / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012640:Seizures / Q000188:drug therapy / Q000209:etiology / Q000601:surgery*; D015173:Supratentorial Neoplasms / Q000150:complications / Q000601:surgery*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants
keywords: Epilepsy; Glioma; Low-grade; Seizure; Temporal lobe