title: Adropin: a new marker for predicting late saphenous vein graft disease after coronary artery bypass grafting.
abstract: OBJECTIVE
  Saphenous vein graft disease (SVGD), defined as an occlusion of 50% or more of the SVG excluding distal anastomotic occlusion, is an important predictor of morbidity after coronary artery bypass grafting (CABG). Late graft occlusion is a serious complication that often limits the use of the saphenous vein as a coronary bypass graft. Late graft occlusion is particularly common in old, degenerated venous grafts with advanced atherosclerotic plaques. Adropin has been implicated in the homeostatic control of metabolism. The purpose of this study was to investigate whether serum adropin levels are associated with late SVGD following CABG.
  
  
  METHODS
  Thirty-eight patients with SVGD involving at least one graft (occluded group; 14 females, 24 males) and 42 patients with a patent saphenous vein graft (patent group; 15 females, 27 males) were enrolled in this study. Venous blood samples were taken from all of the participants to measure plasma adropin levels using an enzyme-linked immunsorbent assay kit.
  
  
  RESULTS
  The mean adropin level was significantly lower in the occluded group than in the patent group (3.2 ± 0.71 vs. 4.9 ± 1.51 ng/mL, p < 0.001). Multivariate regression analysis showed that the adropin level was the independent predictor of late saphenous vein graft occlusion.
  
  
  CONCLUSIONS
  Adropin levels are lower in patients with late saphenous vein graft occlusion and these reduced adropin levels, together with other factors, may lead to saphenous vein graft occlusion. Larger and prospective studies are needed to determine if adropin plays a role in the pathogenesis of SVGD.
authors.forename: Bora
authors.initials: B
authors.lastname: Demircelik
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Cakmak
authors.forename: Yunus
authors.initials: Y
authors.lastname: Nazli
authors.forename: Ozgul M
authors.initials: OM
authors.lastname: Gurel
authors.forename: Nermin
authors.initials: N
authors.lastname: Akkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
authors.forename: Zehra
authors.initials: Z
authors.lastname: Cetin
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Selcoki
authors.forename: Alparslan
authors.initials: A
authors.lastname: Kurtul
authors.forename: Beyhan
authors.initials: B
authors.lastname: Eryonucu
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*; D012501:Saphenous Vein / Q000473:pathology*; D014652:Vascular Diseases / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; C568440:Enho protein, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides