title: Hepatitis C virus prevalence and genotyping among hepatocellular carcinoma patients in Baghdad.
abstract: Hepatocellular carcinoma (HCC) is the third most common cause for cancer death in the world, now being especially linked to chronic hepatitis C virus (HCV) infection. This case-control study consisting of 65 HCC patients and 82 patients with other malignant tumours as controls was conducted to determine the association of HCV markers with HCC. Serum of each participant was obtained for detection of HCV Ab and RNA by DNA enzyme immunoassay (DEIA). Twenty six per cent (26.0%) of HCC patients had positive anti-HCV which was significantly greater than the control group (p=0.001). HCC patients significantly have a risk of exposure to HCV infection almost 3 times than the control group (OR=2.87, 95% C.I=1.1-7). Anti-HCV seropositive rate was significantly (p=0.03) higher among old age HCC patients and increases with age. Males with HCC significantly showed to have more than 9 times risk of exposure to HCV infection (OR=9.375, 95 % CI=1.299-67.647) than females. HCV-RNA seropositive rate was (70.8%) significantly higher among HCC patients compared to (22.2%) the control group (p=0.019). The most prevalent genotype (as a single or mixed pattern of infection) was HCV- 1b. This study detected a significantly higher HCV seropositive rate of antibodies and RNA in HCC patients.
authors.affiliation: Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Sungai Buloh, Malaysia E-mail : waqar_abd@yahoo.co.uk.
authors.forename: Waqar Abd Al Qahar
authors.initials: WA
authors.lastname: Al-Kubaisy
authors.forename: Kadhim Jawad
authors.initials: KJ
authors.lastname: Obaid
authors.forename: Nor Aini Mohd
authors.initials: NA
authors.lastname: Noor
authors.forename: Nik Shamsidah Binti Nik
authors.initials: NS
authors.lastname: Ibrahim
authors.forename: Ahmed Albu-Kareem
authors.initials: AA
authors.lastname: Al-Azawi
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D006801:Humans; D007493:Iraq / Q000453:epidemiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012367:RNA, Viral / Q000235:genetics*; D012307:Risk Factors
chemical_list: D012367:RNA, Viral