title: Antioxidant status and serum levels of selectins in pre-eclampsia.
abstract: A cross-sectional study was conducted in a university hospital, enrolling 40 patients with pre-eclampsia (case group) and 40 healthy normotensive pregnant women (control group). Plasma activity of antioxidants and some adhesion molecules involved in oxidative stress were measured and compared between the two groups, according to the patients' age. In patients over the age of 30 years, serum levels of L-selectin and E-selectin were lower in pre-eclamptic patients (p < 0.05); antioxidants, catalase and superoxide dismutase did not significantly differ between the two groups, while glutathione peroxidase was significantly higher in the normotensive group (p < 0.05). In patients under the age of 30 years, E-selectin was significantly higher in the pre-eclampsia group (p < 0.05), while P-selectin, catalase and superoxide dismutase were not significantly different between the two groups (p > 0.05). Total antioxidative activity was similar between pre-eclamptic and normotensive patients (p > 0.05). This study revealed no relationship between total antioxidant activity and pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Fatemieh Hospital, Hamedan University of Medical Sciences , Hamedan.
authors.forename: S
authors.initials: S
authors.lastname: Nasrollahi
authors.forename: S M
authors.initials: SM
authors.lastname: Hoseini Panah
authors.forename: H
authors.initials: H
authors.lastname: Tavilani
authors.forename: S
authors.initials: S
authors.lastname: Tavasoli
authors.forename: M
authors.initials: M
authors.lastname: Naderan
authors.forename: S
authors.initials: S
authors.lastname: Shoar
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D019087:Selectins / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D019087:Selectins; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione
keywords: Adhesion molecules; catalase; glutathione peroxidase; pre-eclampsia; selectin; superoxide dismutase