title: Jejunal overexpression of peptide YY in celiac disease complicated with pneumatosis cystoides intestinalis.
abstract: A 61-year old man with coeliac disease and chronic lack of appetite, malabsorption and weight loss, despite the gluten-free diet, was operated because of a sub-diaphragmatic free air due to a small-bowel pneumatosis cystoides intestinalis (PCI). The jejunum showed granulomatous lesions with a honeycombed appearance of air cysts in the submucosa/subserosa. We found overexpression of peptide YY (PYY) into only the jejunum with PCI, while the expression was very weak or absent in the tissue without cysts. One year after surgery, he had no abdominal pain or PCI recurrence. The above chronic symptoms were plausibly attributable to the PYY.
authors.affiliation: Unit of Endocrine, Digestive and Emergency Surgery, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Gurrado
authors.affiliation: Unit of Endocrine, Digestive and Emergency Surgery, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Giungato
authors.affiliation: Internal Medicine Units, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124, Bari, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Catacchio
authors.affiliation: Unit of Pathology, Department of Emergency Surgery and Organ Transplantation, University Medical School, 70124, Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Piscitelli
authors.affiliation: Unit of Pathology, Department of Emergency Surgery and Organ Transplantation, University Medical School, 70124, Bari, Italy.
authors.forename: Graziana
authors.initials: G
authors.lastname: Arborea
authors.affiliation: Unit of Endocrine, Digestive and Emergency Surgery, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Piccinni
authors.affiliation: Unit of Endocrine, Digestive and Emergency Surgery, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy. mario.testini@uniba.it.
authors.forename: Mario
authors.initials: M
authors.lastname: Testini
authors.affiliation: Internal Medicine Units, Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, 70124, Bari, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Vacca
mesh_terms: D002446:Celiac Disease / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007583:Jejunum / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019894:Peptide YY / Q000032:analysis*; D011006:Pneumatosis Cystoides Intestinalis / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D019894:Peptide YY
keywords: Coeliac disease (CD); Peptide YY; Pneumatosis cystoides intestinalis (PCI); Small bowel; Surgery