title: Stem cells and motor recovery after stroke.
abstract: In stroke patients with severe persistent neurological deficits, alternative therapeutic modalities are limited. Stem cell therapy might be an opportunity when the safety profile of this approach will be achieved. This review will give possible mechanisms of restoration of function in animals and a statement of clinical trials in humans. The sources of neural stem cells for therapeutic use will be detailed. Potentials mechanisms of transplanted cell-mediated recovery are described with a particular emphasis on ipsilesional post-stroke plasticity. The optimal conditions for cell transplant therapy after stroke are evoked but not yet clearly defined. Finally, since multimodality imaging will be crucial in the post-transplantation patient assessment, the final part describes recent advances in the in vivo monitoring of repair progress.
authors.affiliation: Inserm, imagerie cérébrale et handicaps neurologiques UMR 825, 31059 Toulouse, France; UPS, imagerie cérébrale et handicaps neurologiques UMR 825, université de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France. Electronic address: isabelle.loubinoux@inserm.fr.
authors.forename: I
authors.initials: I
authors.lastname: Loubinoux
authors.affiliation: Inserm, imagerie cérébrale et handicaps neurologiques UMR 825, 31059 Toulouse, France; UPS, imagerie cérébrale et handicaps neurologiques UMR 825, université de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France; CNRS-LAAS, 7, avenue du Colonel-Roche, 31077 Toulouse, France.
authors.forename: B
authors.initials: B
authors.lastname: Demain
authors.affiliation: Inserm, imagerie cérébrale et handicaps neurologiques UMR 825, 31059 Toulouse, France; UPS, imagerie cérébrale et handicaps neurologiques UMR 825, université de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France.
authors.forename: C
authors.initials: C
authors.lastname: Davoust
authors.affiliation: Inserm, imagerie cérébrale et handicaps neurologiques UMR 825, 31059 Toulouse, France; UPS, imagerie cérébrale et handicaps neurologiques UMR 825, université de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France; Pôle neurosciences, centre hospitalier universitaire de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Plas
authors.affiliation: Inserm, imagerie cérébrale et handicaps neurologiques UMR 825, 31059 Toulouse, France; UPS, imagerie cérébrale et handicaps neurologiques UMR 825, université de Toulouse, CHU Purpan, place du Dr-Baylac, 31059 Toulouse cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Vaysse
mesh_terms: D006801:Humans; D058953:Neural Stem Cells / Q000637:transplantation*; D059906:Neuroimaging / Q000379:methods; D009473:Neuronal Plasticity; D020127:Recovery of Function; D020521:Stroke / Q000601:surgery*
keywords: Accident vasculaire cérébral; Cellules souches; Neurogenesis; Neurogenèse; Neuroimagerie; Neuroimaging; Rehabilitation; Réhabilitation; Stem cells; Stroke