title: Taurine attenuates hippocampal and corpus callosum damage, and enhances neurological recovery after closed head injury in rats.
abstract: The protective effects of taurine against closed head injury (CHI) have been reported. This study was designed to investigate whether taurine reduced white matter damage and hippocampal neuronal death through suppressing calpain activation after CHI in rats. Taurine (50 mg/kg) was administered intravenously 30 min and 4 h again after CHI. It was found that taurine lessened the corpus callosum damage, attenuated the neuronal cell death in hippocampal CA1 and CA3 subfields and improved the neurological functions 7 days after CHI. Moreover, it suppressed the over-activation of calpain, enhanced the levels of calpastatin, and reduced the degradation of neurofilament heavy protein, myelin basic protein and αII-spectrin in traumatic tissue 24 h after CHI. These data confirm the protective effects of taurine against gray and white matter damage due to CHI, and suggest that down-regulating calpain activation could be one of the protective mechanisms of taurine against CHI.
authors.affiliation: Department of Neuropharmacology, Beijing Neurosurgical Institute, Capital Medical University, Beijing Key Laboratory of Central Nervous System Injury, China National Clinical Research Center for Neurological Diseases, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Neuropharmacology, Beijing Neurosurgical Institute, Capital Medical University, Beijing Key Laboratory of Central Nervous System Injury, China National Clinical Research Center for Neurological Diseases, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing Key Laboratory of Central Nervous System Injury, China National Clinical Research Center for Neurological Diseases, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, China.
authors.forename: K
authors.initials: K
authors.lastname: Qian
authors.affiliation: Department of Neuropharmacology, Beijing Neurosurgical Institute, Capital Medical University, Beijing Key Laboratory of Central Nervous System Injury, China National Clinical Research Center for Neurological Diseases, No. 6 Tiantan Xili, Dongcheng District, Beijing 100050, China. Electronic address: sunming999@yahoo.com.
authors.forename: M
authors.initials: M
authors.lastname: Sun
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D056654:CA3 Region, Hippocampal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000378:metabolism; D002154:Calpain / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects; D003337:Corpus Callosum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D066128:Gray Matter / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016489:Head Injuries, Closed / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D004676:Myelin Basic Protein / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011897:Random Allocation; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*; D066127:White Matter / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D002135:Calcium-Binding Proteins; D004676:Myelin Basic Protein; D016900:Neurofilament Proteins; D018696:Neuroprotective Agents; C051774:neurofilament protein H; D013654:Taurine; C033668:calpastatin; D002154:Calpain
keywords: calpain; closed head injury; corpus callosum; hippocampus; taurine