title: Emerging trends in heart valve engineering: Part III. Novel technologies for mitral valve repair and replacement.
abstract: In this portion of an extensive review of heart valve engineering, we focus on the current and emerging technologies and techniques to repair or replace the mitral valve. We begin with a discussion of the currently available mechanical and bioprosthetic mitral valves followed by the rationale and limitations of current surgical mitral annuloplasty methods; a discussion of the technique of neo-chordae fabrication and implantation; a review the procedures and clinical results for catheter-based mitral leaflet repair; a highlight of the motivation for and limitations of catheter-based annular reduction therapies; and introduce the early generation devices for catheter-based mitral valve replacement.
authors.affiliation: Department of Biomedical Engineering, The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, 2410 Engineering Hall, Irvine, CA, 92697-2730, USA, arashkh@uci.edu.
authors.forename: Arash
authors.initials: A
authors.lastname: Kheradvar
authors.forename: Elliott M
authors.initials: EM
authors.lastname: Groves
authors.forename: Craig A
authors.initials: CA
authors.lastname: Simmons
authors.forename: Boyce
authors.initials: B
authors.lastname: Griffith
authors.forename: S Hamed
authors.initials: SH
authors.lastname: Alavi
authors.forename: Robert
authors.initials: R
authors.lastname: Tranquillo
authors.forename: Lakshmi P
authors.initials: LP
authors.lastname: Dasi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Falahatpisheh
authors.forename: K Jane
authors.initials: KJ
authors.lastname: Grande-Allen
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Goergen
authors.forename: Mohammad R K
authors.initials: MR
authors.lastname: Mofrad
authors.forename: Frank
authors.initials: F
authors.lastname: Baaijens
authors.forename: Suncica
authors.initials: S
authors.lastname: Canic
authors.forename: Stephen H
authors.initials: SH
authors.lastname: Little
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008943:Mitral Valve; D023822:Tissue Engineering / Q000379:methods* / Q000639:trends*