title: Comparison of salivary and serum glucose levels in diabetic patients.
abstract: Diabetes mellitus is a noncommunicable disease with a rising prevalence worldwide and in developing countries. The most commonly used diagnostic biofluid for detection of glucose levels is blood, but sample collection is an invasive and painful procedure. Thus, there arises a need for a noninvasive and painless technique to detect glucose levels. The objectives of the present study were to estimate the glucose levels of saliva, to assess if any significant correlation existed between the serum and salivary glucose levels, and to correlate salivary glucose levels with regard to duration of diabetes, age, and gender. In the present study, serum and salivary glucose levels of 200 subjects (100 diabetic subjects and 100 nondiabetic subjects) were estimated by glucose oxidase method. Glycosylated hemoglobin levels were also measured in randomly selected 40 diabetic subjects. The findings of present study revealed a significant correlation between salivary and serum glucose levels in both diabetic and nondiabetic subjects. No significant relationship was observed between salivary glucose levels and gender or age in both diabetics and nondiabetics and between salivary glucose levels and duration of diabetes in diabetics. On the basis of the findings, it was concluded that salivary glucose levels could serve as a potentially noninvasive adjunct to monitor glycemic control in diabetic patients.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Luxmi Bai Institute of Dental Sciences and Hospital, Patiala, Punjab, India guptashruti.82@gmail.com.
authors.forename: Shruti
authors.initials: S
authors.lastname: Gupta
authors.affiliation: Department of Oral and Maxillofacial Pathology, Genesis Institute of Dental Sciences and Research, Ferozepur, Punjab, India.
authors.forename: Simarpreet Virk
authors.initials: SV
authors.lastname: Sandhu
authors.affiliation: Department of Oral and Maxillofacial Pathology, Baba Jaswant Singh Dental College Hospital and Research Institute, Ludhiana, Punjab, India.
authors.forename: Himanta
authors.initials: H
authors.lastname: Bansal
authors.affiliation: Department of Oral and Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India.
authors.forename: Deepti
authors.initials: D
authors.lastname: Sharma
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D005947:Glucose; D006442:Glycated Hemoglobin
keywords: diabetes mellitus; glucose; noninvasive; postprandial; saliva; serum