title: Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients.
abstract: This study explored the role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy and duration of action of rocuronium in Chinese patients. Two hundred seven unrelated Chinese patients scheduled for elective surgery were recruited, and 200 completed the study. Their ABCB1, SLCO1B1, and CHRNA1 genotypes were determined. Demographic and clinical non-genetic data also were collected. The SLCO1B1, ABCB1, and CHRNA1 variants did not affect the onset time of rocuronium. Clinical duration and recovery time of rocuronium were prolonged in patients with the ABCB1 rs1128503TT and SLCO1B1 rs2306283 AG and GG genotypes. We demonstrate that the SLCO1B1 and ABCB1 gene variants could affect the pharmacodynamics of rocuronium. The ABCB1 rs1128503 C>T genotype was the most important factor on the efficacy of rocuronium.
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Mei
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.|Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Sai-Ying
authors.initials: SY
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Shuang-Qiang
authors.initials: SQ
authors.lastname: Yi
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Mi
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Kai-Ming
authors.initials: KM
authors.lastname: Duan
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics / Q000378:metabolism; D000328:Adult; D000732:Androstanols / Q000493:pharmacokinetics / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics*; D002681:China; D017558:Elective Surgical Procedures; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D027381:Liver-Specific Organic Anion Transporter 1 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013517:Otorhinolaryngologic Surgical Procedures; D010597:Pharmacogenetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011978:Receptors, Nicotinic / Q000235:genetics* / Q000378:metabolism; D000077123:Rocuronium
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D000732:Androstanols; C523021:CHRNA1 protein, human; D027381:Liver-Specific Organic Anion Transporter 1; D003473:Neuromuscular Nondepolarizing Agents; D011978:Receptors, Nicotinic; C503999:SLCO1B1 protein, human; D000077123:Rocuronium
keywords: ABCB1; CHRNA1; SLCO1B1; genetic polymorphism; pharmacogenetics