title: Improved cell activity on biodegradable photopolymer scaffolds using titanate nanotube coatings.
abstract: The development of bioactive materials is in the premise of tissue engineering. For several years, surface functionalization of scaffolds has been one of the most promising approaches to stimulate cellular activity and finally improve implant success. Herein, we describe the development of a bioactive composite scaffold composed of a biodegradable photopolymer scaffold and titanate nanotubes (TNTs). The biodegradable photopolymer scaffolds were fabricated by applying mask-projection excimer laser photocuring at 308 nm. TNTs were synthesized and then spin-coated on the porous scaffolds. Upon culturing fibroblast cells on scaffolds, we found that nanotubes coating affects cell viability and proliferation demonstrating that TNT coatings enhance cell growth on the scaffolds by further improving their surface topography.
authors.affiliation: Nanophysics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy. Electronic address: szabolcs.beke@iit.it.
authors.forename: S
authors.initials: S
authors.lastname: Beke
authors.affiliation: IEIIT, National Research Council (CNR), Via De Marini 6, 16149 Genova, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Barenghi
authors.affiliation: Nanophysics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Farkas
authors.affiliation: Nanophysics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Romano
authors.affiliation: Department of Biotechnology, Nanophage Therapy Center, Enviroinvest Corporation, Kertváros u. 2, H-7632 Pécs, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Kőrösi
authors.affiliation: IEIIT, National Research Council (CNR), Via De Marini 6, 16149 Genova, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Scaglione
authors.affiliation: Nanophysics, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy; Istituto Nazionale di Ottica, CNR, Via G. Moruzzi 1, 56124-Pisa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Brandi
mesh_terms: D016475:3T3 Cells; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D051379:Mice; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D014025:Titanium
keywords: Cell culturing; Excimer laser; Laser photocuring; Scaffolds; Tissue engineering; Titanate nanotubes