title: Trichiconins A-C, limonoids with new carbon skeletons from Trichilia connaroides.
abstract: Three limonoids, trichiconin A (1) possessing a new carbon skeleton of a rearranged A,B-ring system and trichiconins B (2) and C (3) featuring an unprecedented A,B,D-seco skeleton, were isolated from the twigs of Trichilia connaroides. The carbon scaffold of trichiconin A is designated as trichiconane. Their structures with absolute stereochemistry were determined by spectroscopic data, X-ray crystallography, and CD analysis. Compounds 2 and 3 showed modest anti-HIV activities.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Liu
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Xu
authors.forename: Ying-Shan
authors.initials: YS
authors.lastname: Han
authors.forename: Mark A
authors.initials: MA
authors.lastname: Wainberg
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yue
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D036701:Limonins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D029582:Meliaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D036701:Limonins; C000599398:trichiconin A; C000599399:trichiconin B; C000599400:trichiconin C