title: Targeting bacterial virulence: the coming out of type VII secretion inhibitors.
abstract: Type VII (ESX) secretion systems of pathogenic mycobacteria, such as Mycobacterium tuberculosis, are crucial for intracellular survival, host cell lysis, and the subsequent cell-to-cell spread. In this issue of Cell Host & Microbe, Rybniker et al. (2014) have used these characteristics to identify two classes of type VII secretion inhibitors.
authors.affiliation: Department of Medical Microbiology, VU University Medical Center, 1081 BT Amsterdam, the Netherlands; Molecular Microbiology, VU University, 1081 HV Amsterdam, The Netherlands. Electronic address: w.bitter@vumc.nl.
authors.forename: Wilbert
authors.initials: W
authors.lastname: Bitter
authors.affiliation: Department of Medical Microbiology, VU University Medical Center, 1081 BT Amsterdam, the Netherlands.
authors.forename: Coen
authors.initials: C
authors.lastname: Kuijl
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000942:Antigens, Bacterial; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005347:Fibroblasts / Q000502:physiology*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000378:metabolism*; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D037521:Virulence Factors