title: Doppler assessment of renal hemodynamic alterations in homozygous sickle cell disease and sickle Beta-thalassemia.
abstract: We evaluated the renal vascular indices in children and adolescents with sickle cell disease (SCD) using Doppler ultrasonography. We also assessed the renal hemodynamics alterations in patients with homozygous SCD and sickle beta-thalassemia (sickle β-thalassemia). We studied 75 patients (age range = 3-20 years; M = 9.95 ± 4.15) with SCD: 42 patients suffering from homozygous SCD and 33 patients diagnosed with sickle β-thalassemia. Thirty, age- and sex-matched, normal subjects were also included as a control group. Both patients and control groups had Doppler assessment of pulsatility (PI) and resistivity (RI) indices of main renal, segmental, interlobar, and arcuate arteries. Both PIs and RIs were significantly higher in SCD patients, compared with the control group. Among patients, PIs and RIs in the main renal, segmental, interlobar, and arcuate arteries were significantly higher in patients with homozygous SCD as compared with those with sickle β-thalassemia (p values <0.01, <0.001, <0.001, and <0.001 for PIs and <0.001, <0.001, <0.001, and <0.01 for RIs, respectively). We concluded that renal vascular resistance is raised in children and adolescents with SCD. This is more pronounced in patients with homozygous SCD as compared with those with sickle β-thalassemia.
authors.affiliation: Internal Medicine Department, Cairo University, Cairo, Egypt aasemsaif@yahoo.com.
authors.forename: Aasem
authors.initials: A
authors.lastname: Saif
authors.affiliation: Department of Pediatrics, Cairo University, Cairo, Egypt.
authors.forename: Neveen
authors.initials: N
authors.lastname: Soliman
authors.affiliation: Vascular Laboratory, Cairo University, Cairo, Egypt.
authors.forename: Alaa
authors.initials: A
authors.lastname: Abdelhamid
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance; D055815:Young Adult; D017086:beta-Thalassemia / Q000000981:diagnostic imaging* / Q000503:physiopathology*
keywords: Doppler ultrasonography; pulsatility index; renal arteries; resistivity index; sickle beta-thalassemia; sickle cell disease