title: [Intestinal microflora, obesity and type 2 diabetes].
abstract: The review of data of the literature on a role of intestinal microflora, genetic features of a macroorganism, exogenic factors and character of a food is presented at obesity and a type 2 diabetes. Researches establish, that development in experimental animals of the induced obesity and the type 2 diabetes, depends on a diet and presence of intestinal microflora. The factors increasing permeability mucous intestines, promote a translocation of intestinal automicroflora and its toxins into macroorganism and a system blood-circulation. Long introduction LPS (endotoxin) of gram-negative bacteria to the special laboratory animals led to development of inflammatory reaction, adiposity and resistance to insulin. The specified phenomena did not develop at LPS introduction to the animals, who have lost receptor CD14 which is necessary for linkage and endotoxin action. Data about change of intestinal microflora and a role of immune infringements are discussed at obesity and the type 2 diabetes occurring into background of low-grade chronic inflammation and metabolic disorders.
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
authors.forename: V V
authors.initials: VV
authors.lastname: Maleev
authors.forename: V G
authors.initials: VG
authors.lastname: Likhoded
mesh_terms: D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000473:pathology; D007422:Intestines / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000633:toxicity; D064307:Microbiota; D009765:Obesity / Q000178:diet therapy / Q000382:microbiology* / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides