title: Synthesis, Structural Characterization, and Evaluation of the Biological Properties of Heteroleptic Palladium(II) Complexes.
abstract: Five heteroleptic palladium(II) complexes of the general formula Pd(PR3)(tu)Cl2, where PR3 = triphenylphosphine (1), diphenyl-o-tolylphosphine (2), diphenyl-p-tolylphosphine (3), diphenyl-t-butylphosphine (4), and diphenyl-o-methoxyphenylphosphine (5), and tu = 1,3-bis(2-methoxyphenyl) thiourea. They all have been synthesized and characterized by various spectroscopic techniques (elemental analysis, FTIR, and (1)H NMR and the ligand 1,3-bis(2-methoxyphenyl) thiourea was synthesized by single crystal X-ray diffraction technique). The synthesized compounds were screened for their antibacterial activity against four strains of bacteria (Escherichia coli, Shigella flexneri, Staphylococcus aureus, and Bacillus subtilis). The antitumor potential was evaluated in terms of activity against brine shrimp eggs and DNA interaction. The mixed ligand complexes have exhibited moderate antibacterial activity and promising antitumor potential.
authors.affiliation: Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan.
authors.forename: Hizbullah
authors.initials: H
authors.lastname: Khan
authors.affiliation: Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan.
authors.forename: Nek
authors.initials: N
authors.lastname: Daraz
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan.
authors.forename: Muhammad Nasim
authors.initials: MN
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Abdul Wali Khan University, Mardan 23200, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Said
authors.affiliation: Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan.
authors.forename: Nosheen
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Amin
authors.initials: A
authors.lastname: Badshah
authors.affiliation: Department of Chemistry, University of Science and Technology, Bannu 28100, Pakistan ; PETRONAS Ionic Liquid Centre, Department of Chemical Engineering, Universiti Teknologi Petronas, Seri Iskandar, 31750 Tronoh, Perak, Malaysia.
authors.forename: Amir Sada
authors.initials: AS
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat 26000, Pakistan.
authors.forename: Murad
authors.initials: M
authors.lastname: Ali