title: Tumoral fibrosis effect on the radiation absorbed dose of (177)Lu-Tyr(3)-octreotate and (177)Lu-Tyr(3)-octreotate conjugated to gold nanoparticles.
abstract: The aim of this work was to evaluate the tumoral fibrosis effect on the radiation absorbed dose of the radiopharmaceuticals (177)Lu-Tyr(3)-octreotate (monomeric) and (177)Lu-Tyr(3)-octreotate-gold nanoparticles (multimeric) using an experimental HeLa cells tumoral model and the Monte Carlo PENELOPE code. Experimental and computer micro-environment models with or without fibrosis were constructed. Results showed that fibrosis increases up to 33% the tumor radiation absorbed dose, although the major effect on the dose was produced by the type of radiopharmaceutical (112Gy-multimeric vs. 43Gy-monomeric).
authors.affiliation: Gerencia de Aplicaciones Nucleares en la Salud y, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, Mexico. Electronic address: erica.azorin@inin.gob.mx.
authors.forename: E P
authors.initials: EP
authors.lastname: Azorín-Vega
authors.affiliation: Gerencia de Aplicaciones Nucleares en la Salud y, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, Mexico; Escuela Superior de Física y Matemáticas. Instituto Politécnico Nacional, México D.F. 07738, Mexico.
authors.forename: O D
authors.initials: OD
authors.lastname: Zambrano-Ramírez
authors.affiliation: Gerencia de Ciencias Ambientales, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, Mexico.
authors.forename: E L
authors.initials: EL
authors.lastname: Rojas-Calderón
authors.affiliation: Gerencia de Aplicaciones Nucleares en la Salud y, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, Mexico.
authors.forename: B E
authors.initials: BE
authors.lastname: Ocampo-García
authors.affiliation: Gerencia de Aplicaciones Nucleares en la Salud y, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac, Estado de México 52750, Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Ferro-Flores
mesh_terms: D005355:Fibrosis; D006046:Gold; D006367:HeLa Cells; D006801:Humans; D008187:Lutetium / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D008954:Models, Biological; D009010:Monte Carlo Method; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000532:radiotherapy*; D015282:Octreotide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011879:Radiotherapy Dosage; D000068936:Theranostic Nanomedicine
chemical_list: C554548:177Lu-octreotate; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D008187:Lutetium; D006046:Gold; D015282:Octreotide
keywords: Gold nanoparticles; Lutetium-177; Monte Carlo; Octreotate; Targeted radiotherapy; Tumoral fibrosis model