title: Syntheses, crystal structures and antioxidant study of Zn(II) complexes with morin-5'-sulfonic acid (MSA).
abstract: The study of modified synthetic procedure of water soluble morin-5'-sulfonic acid sodium salt (NaMSA) involving less aggressive chemicals and carried out at mild conditions was described. The NaMSA salt is a convenient source of anionic morin-5'-sulfonic ligand (MSA) in ion exchange reactions. The coordination ability of MSA ligand towards the zinc cations was investigated in aqueous solution and in solid state. Novel zinc complexes of morin-5'-sulfonate were obtained by a reaction of Zn(NO3)2 with morin-5'-sulfonate in water. Resulting compounds were characterized by single-crystal X-ray diffraction analysis, as well as spectral and thermal methods. The coordination interaction, hydrogen bond and π-π stacking lead to the formation of a 1D chain or 3D coordination polymers. The antioxidant activity of the Zn(II)-MSA complexes was evaluated by means of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method. In this work, we have shown that the studied compounds are more effective free radical scavengers than the natural flavonoids like plain morin.
authors.affiliation: Rzeszow University of Technology, Faculty of Chemistry, Powstańców Warszawy 6, Rzeszów 35-959, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Pieniążek
authors.affiliation: Rzeszow University of Technology, Faculty of Chemistry, Powstańców Warszawy 6, Rzeszów 35-959, Poland. Electronic address: kalembic@prz.edu.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Kalembkiewicz
authors.affiliation: Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, Warszawa 00-664, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Dranka
authors.affiliation: Rzeszow University of Technology, Faculty of Chemistry, Powstańców Warszawy 6, Rzeszów 35-959, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Woźnicka
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D005260:Female; D005419:Flavonoids / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D008314:Malonates / Q000737:chemistry*; D051379:Mice; D041681:NIH 3T3 Cells; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000737:chemistry; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D056831:Coordination Complexes; D005419:Flavonoids; D008314:Malonates; D009944:Organoplatinum Compounds; D011743:Pyrimidines; D013451:Sulfonic Acids; C576986:morin-5'-sulfonic acid; C030290:malonic acid; D015032:Zinc; D002945:Cisplatin
keywords: Antioxidant study; Crystal structure; Morin-5′-sulfonic ligand; Spectral method; Thermogravimetric analysis; Zinc complex