title: Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats.
abstract: In the present study, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean control rats (ZLC) during the onset of diabetes. At 7 weeks of age, ZLC and ZDF rats were either placed on a stationary treadmill or made to run for 1 h/day for 5 consecutive days at 16~22 m/min for 5 weeks. At 12 weeks of age, the ZDF rats had significantly higher blood glucose levels and body weight than the ZLC rats. In addition, malondialdehyde (MDA) levels in the hippocampus of the ZDF rats were significantly higher than those of the ZLC rats whereas SOD1 levels in the hippocampus of the ZDF rats were moderately decreased. Notably, treadmill exercise prevented the increase of blood glucose levels in ZDF rats. In addition, treadmill exercise significantly ameliorated changes in MDA and SOD1 levels in the hippocampus although SOD activity was not altered. These findings suggest that diabetes increases lipid peroxidation and decreases SOD1 levels, and treadmill exercise can mitigate diabetes-induced oxidative damage in the hippocampus.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
authors.forename: Jong Whi
authors.initials: JW
authors.lastname: Kim
authors.forename: Junghyun
authors.initials: J
authors.lastname: Chae
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Nam
authors.forename: Yo Na
authors.initials: YN
authors.lastname: Kim
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Yoo
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Hyo Young
authors.initials: HY
authors.lastname: Jung
authors.forename: Wook
authors.initials: W
authors.lastname: Song
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Je Kyung
authors.initials: JK
authors.lastname: Seong
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005838:Genotype; D006624:Hippocampus / Q000201:enzymology* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011924:Rats, Zucker; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase
keywords: Cu,Zn-superoxide dismutase; hippocampus; lipid peroxidation; treadmill exercise; type 2 diabetes