title: [Withdrawal versus continuation of antipsychotic drugs in people with dementia].
abstract: Antipsychotics are often prescribed for treatment of psychiatric symptoms. The efficacy is very limited and must be weighed against the risk of adverse effects. A Cochrane review included randomized, placebo-controlled trials comparing an antipsychotic withdrawal with continuing treatment. Nine studies (606 patients) were included. Only in two studies with patients who had responded to antipsychotic treatment, withdrawal resulted in an increased risk of relapse. Withdrawal of antipsychotics should be incorporated in daily practice in primary care.
authors.affiliation: Psykiatrisk Afdeling Odense - Universitetsfunktion, Psykiatrien i Region Syddanmark, Sdr. Boulevard 29, 5000 Odense C. E-mail: annette.lolk@rsyd.dk.
authors.forename: Annette
authors.initials: A
authors.lastname: Lolk
mesh_terms: D000368:Aged; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003704:Dementia / Q000523:psychology*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy*; D011595:Psychomotor Agitation / Q000188:drug therapy*; D012008:Recurrence; D012196:Review Literature as Topic
chemical_list: D014150:Antipsychotic Agents