title: Sites of Basal cell carcinomas and head and neck congenital clefts: topographic correlation.
abstract: BACKGROUND
  The embryologic fusion planes might be related with the sites of onset of basal cell carcinoma (BCC), thus supporting an embryologic role for its pathogenesis.
  
  
  METHODS
  A study involving 495 patients with 627 BCCs of the head and neck was carried out over a period of 5 years by correlating the distribution of all BCCs with the sites of congenital clefts of the head and neck using (1) the original anatomic diagram of the Tessier classification of craniofacial clefts, (2) the anatomic diagram by Moore et al featuring the paths of the "hairline indicators" of craniofacial clefts that represent the cranial extensions of the Tessier classification, and (3) an anatomical diagram featuring the sites of congenital clefts of the neck.
  
  
  RESULTS
  The proportion of BCCs localized within a cleft site was significantly higher than those in the noncleft sites. The age of patients with BCCs localized within the Tessier cleft number 3 was the lowest among all cleft regions.
  
  
  CONCLUSIONS
  A topographic correspondence between the sites of BCCs and the sites of congenital clefts was demonstrated in the head and neck. This evidence would support the hypothesis of an embryologic role for the pathogenesis of BCC. The existence of clusters of embryological stem cells in the sites of fusion and/or merging of embryonic processes might therefore be proposed. There may be special biology/physiology along these cleft lines that predispose BCC formation.
authors.affiliation: Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy; Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy; and Laboratory of Informatics and Systems Engineering for Clinical Research, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Nicoletti
authors.affiliation: Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy; Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy; and Laboratory of Informatics and Systems Engineering for Clinical Research, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Brenta
authors.affiliation: Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy; Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy; and Laboratory of Informatics and Systems Engineering for Clinical Research, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Malovini
authors.affiliation: Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy; Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy; and Laboratory of Informatics and Systems Engineering for Clinical Research, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
authors.forename: Omar
authors.initials: O
authors.lastname: Jaber
authors.affiliation: Plastic and Reconstructive Surgery, Department of Clinical Surgical Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy; Advanced Technologies for Regenerative Medicine and Inductive Surgery Research Centre, University of Pavia, Pavia, Italy; Plastic and Reconstructive Surgery Unit, Salvatore Maugeri Research and Care Institute, Pavia, Italy; Department of Computer Engineering and Systems Science, University of Pavia, Pavia, Italy; and Laboratory of Informatics and Systems Engineering for Clinical Research, Salvatore Maugeri Research and Care Institute, Pavia, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Faga