title: B-cell hyperactivity in murine lupus II. Defects in response to and production of accessory signals in lupus-prone mice.
abstract: The first part of this discussion, published in last month's issue (p. 287), reviewed the immunological abnormalities observed in murine lupus. The current theories on the signal requirements for B cell activation, proliferation, and differentiation were also described. This month, the authors discuss recent experiments which suggest that the B cell hyperactivity associated with lupus may be the result of abnormal responses to and/or production of T-cell-derived B-cell-activating factors.
authors.affiliation: Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, CA 92037, USA.
authors.forename: A N
authors.initials: AN
authors.lastname: Theofilopoulos
authors.forename: G J
authors.initials: GJ
authors.lastname: Prud'homme
authors.forename: T M
authors.initials: TM
authors.lastname: Fieser
authors.forename: F J
authors.initials: FJ
authors.lastname: Dixon