title: Serum DJ-1 level is positively associated with improvements in some aspects of metabolic syndrome in Japanese women through lifestyle intervention.
abstract: DJ-1 is a protein that is associated with Parkinson disease and cancer, and the reduction of DJ-1 function and expression is also thought to be a cause of diabetes and hypertension. However, little is known about the association between the plasma concentration of DJ-1 and risk of metabolic syndrome. We hypothesized that a lifestyle intervention would increase serum DJ-1 and that up-regulated DJ-1 functions will result in the prevention of metabolic syndrome. The objective of our study is to examine whether the level of serum DJ-1 is associated with the risk of metabolic syndrome. Therefore, to reveal the association between DJ-1 and metabolic syndrome, this study investigated lifestyle intervention in a control group (n = 37) and intervention group (n = 45). The results showed that body mass index, body fat ratio, waist-hip ratio, waist circumference, blood pressure, and plasma glucose level were improved in the intervention group, as compared with those in the control group. Furthermore, serum levels of DJ-1 were increased in the intervention group, when compared with those in the control group. These results suggest that serum DJ-1 is increased by lifestyle intervention and that increased serum DJ-1 prevents metabolic syndrome. Thus, the level of serum DJ-1 will become one of the indexes for the risk of metabolic syndrome.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: t-yamane@pharm.hokudai.ac.jp.
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamane
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Sato
authors.initials: S
authors.lastname: Murao
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Kozuka
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Mari
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Junko
authors.initials: J
authors.lastname: Suzuki
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Chizuru
authors.initials: C
authors.lastname: Kubo
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Yamaguchi
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Musashi
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Minegishi
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Momose
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Mami
authors.initials: M
authors.lastname: Matsushita
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Shirahata
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Furukawa
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kobayashi
authors.affiliation: Faculty of Health and Welfare, Department of Nutrition, Nayoro City University, Nayoro 096-8641, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Umezawa
authors.affiliation: Faculty of Human Science, Department of Health and Nutrition, Hokkaido Bunkyo University, Eniwa 061-1449, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Sakamoto
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Moriya
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Saito
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Makita
authors.affiliation: Department of Nutrition, School of Nursing and Nutrition, Tenshi College, Sapporo 065-0013, Japan.
authors.forename: Iwao
authors.initials: I
authors.lastname: Ohkubo
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Ariga
mesh_terms: D000273:Adipose Tissue; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D049628:Body Size; D003920:Diabetes Mellitus / Q000209:etiology; D004032:Diet; D015444:Exercise; D005260:Female; D015438:Health Behavior; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D007564:Japan; D008019:Life Style; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000628:therapy; D015513:Oncogene Proteins / Q000097:blood*; D000071617:Protein Deglycase DJ-1
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1
keywords: DJ-1; Improvement; Lifestyle intervention; Metabolic syndrome; Risk factor