title: Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women.
abstract: OBJECTIVE
  Recent studies suggest that serum lipid profiles are related to bone mineral density (BMD). But data about this relationship on Chinese population are scarce. We investigated the relationships between serum lipid and BMD in postmenopausal Chinese women.
  
  
  METHODS
  A cross-sectional study was conducted in 790 Chinese postmenopausal women. BMDs were measured by dual X-ray absorptiometry. Serum lipid profiles were obtained after a 12-h fasting.
  
  
  RESULTS
  Women with serum high-density lipoprotein cholesterol (HDL-C) levels of at least 1·55 mmol/l had a greater prevalence of osteoporosis compared with women with lower HDL-C (≤1·54 mmol/l). After controlling for age, menopausal duration, body mass index, serum creatinine levels, outdoor activity, smoking and alcohol intake, high HDL-C levels were associated with osteoporosis (OR = 1·64, 95%CI 1·16-2·33, P < 0·01). BMD at femoral neck and total hip was significantly lower in the higher HDL-C class than the lower class (0·722 ± 0·118 vs 0·744 ± 0·120 g/cm(2) , P < 0·01; 0·800 ± 0·126 vs 0·824 ± 0·125 g/cm(2) , P < 0·01, respectively). No association was found between total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) with BMD.
  
  
  CONCLUSIONS
  In Chinese postmenopausal women, elevated levels of serum HDL-C had a greater probability of being osteoporosis than the lower HDL-C levels. Our analysis showed higher HDL-C level that is favourable for cardiovascular diseases should be regarded as a risk factor for osteoporosis.
authors.affiliation: Department of Metabolism and Endocrinology, the Second Xiang-Ya Hospital, Central South University, Changsha, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Li
authors.forename: Hongbing
authors.initials: H
authors.lastname: Guo
authors.forename: Youshuo
authors.initials: Y
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhimin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Xie
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Sheng
authors.forename: Eryuan
authors.initials: E
authors.lastname: Liao
mesh_terms: D000368:Aged; D015519:Bone Density / Q000502:physiology*; D002681:China / Q000208:ethnology; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000208:ethnology / Q000378:metabolism*; D017698:Postmenopause / Q000097:blood / Q000208:ethnology / Q000378:metabolism*
chemical_list: D008076:Cholesterol, HDL