title: Role of nocturnal penile erection test on response to daily sildenafil in patients with erectile dysfunction due to pelvic fracture urethral disruption: a single-center experience.
abstract: OBJECTIVE
  To evaluate the results of nocturnal penile erection test and response to daily sildenafil in patients with erectile dysfunction (ED) due to pelvic fracture urethral disruption.
  
  
  METHODS
  From January 2010 to January 2012, we included 38 patients with ED due to pelvic fracture urethral disruption. The mean age was 33.1 years (range, 22-49 years). All were evaluated subjectively and objectively by the International Index of Erectile Function-5, nocturnal penile tumescence and rigidity (NPTR) test, and penile Doppler ultrasonography. Patients received daily sildenafil 50 mg for 3 months.
  
  
  RESULTS
  Thirty-one patients were followed up: 54.8% showed response to sildenafil defined as reporting successful vaginal penetration and intercourse. Patients with neurogenic, arterial, and venous EDs did not differ in efficiency rates (P = .587). However, the penile erectile rigidity recorded by NPTR test affected efficiency significantly (P = .046). Patients with tip rigidity >40% had the highest response rate (76.9%), but the response rate for patients with tip rigidity <20% was only 22.2%.
  
  
  CONCLUSIONS
  NPTR recording can reveal resident erectile function in patients with ED due to trauma and is significant for selecting pharmacologic treatment as optimal therapy.
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Peng
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China. Electronic address: zhangzhichao@bjmu.edu.cn.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Wanshou
authors.initials: W
authors.lastname: Cui
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Gao
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Song
authors.affiliation: Andrology Center, Peking University First Hospital, Beijing, China.
authors.forename: Zhongcheng
authors.initials: Z
authors.lastname: Xin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002940:Circadian Rhythm; D015331:Cohort Studies; D003950:Diagnostic Techniques, Urological; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology; D050723:Fractures, Bone / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications / Q000175:diagnosis; D010384:Pelvic Bones / Q000293:injuries*; D010410:Penile Erection / Q000187:drug effects; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D012189:Retrospective Studies; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D018608:Ultrasonography, Doppler; D014521:Urethra / Q000293:injuries*; D055815:Young Adult
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate