title: A deeper understanding of the association between CTLA4 +49A/G and acute rejection in renal transplantation: an updated meta-analysis.
abstract: To reevaluate the association between the costimulatory molecule cytotoxic T lymphocyte-associated antigen4 (CTLA4) single nucleotide polymorphism (SNP) +49A/G and acute rejection (AR) in renal transplantation, nine studies published before June 2013 were analyzed. Meta-analysis and cumulative meta-analysis (metacum) were performed for each genotype in a random/fixed effect model. The combined odds ratios (OR) with 95% confidence intervals (CI) were calculated to estimate the strength of the association. In the sensitivity analysis, a single study involved in the meta-analysis was deleted each time to investigate the influence of the individual data sets on the pooled ORs. Meta-analysis regression was used for some influence factors, such as year of publication, total number in each group (AR group and control group), ethnicity, the ratio of GG to GA + AA, the ratio of G to A in CTLA4 +49A/G. Overall, a significant correlation was noted between the CTLA4 SNP (+49A/G) and the risk of AR (for GG vs. AG + AA: OR = 1.35, 95% CI = 1.05-1.73, p = 0.02; for G vs. A: OR = 1.21, 95% CI = 1.03-1.42, p = 0.02), especially in the Asian subgroup (for GG vs. AG + AA: OR = 1.79, 95% CI = 1.15-2.78, p = 0.009; for G vs. A: OR = 1.47, 95% CI = 1.04-2.07, p = 0.03). Of the influence factors, the ratio of GG to GA+AA (p = 0.046) and the ratio of G to A (p = 0.017) were significant factors. In conclusion, our results suggest that CTLA4 +49A/G contribute to the risk of AR following renal transplantation.
authors.affiliation: Department of Clinical Pharmacy, Shanghai First People's Hospital, Shanghai Jiao Tong University , Shanghai , China .
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Gao
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Zhou
authors.forename: Sheng-Cong
authors.initials: SC
authors.lastname: Guo
authors.forename: Yi-Feng
authors.initials: YF
authors.lastname: Guo
authors.forename: Fang
authors.initials: F
authors.lastname: Guo
mesh_terms: D060908:CTLA-4 Antigen / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D020641:Polymorphism, Single Nucleotide
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human
keywords: Acute rejection; cytotoxic T lymphocyte-associated antigen4; meta-analysis; single nucleotide polymorphism