title: Epidemiology, prognosis and treatment of simultaneous squamous cell carcinomas of the oral cavity and hypopharynx.
abstract: OBJECTIVE
  The study was designed to assess the prevalence, management and survival of patients with simultaneous squamous cell carcinomas of the oral cavity and hypopharynx (OC/HP).
  
  
  METHODS
  A multicenter, retrospective study (2 university hospitals) was conducted between 2003 and 2007 on a series of 96 patients with simultaneous squamous cell cancers of the OC/HP.
  
  
  RESULTS
  A total of 88 men and 8 women were included in the study: 81 patients presented double sites, 14 presented triple sites and one presented quadruple sites. The tumour sites most frequently observed were: hypopharynx in 61% of cases (involving the pyriform sinus in 42% of cases) and the oropharynx in 59% of cases (involving the palatine tonsil in 30% of cases). Upper aerodigestive tract endoscopy under general anaesthesia revealed a simultaneous lesion not suspected on clinical examination in 45% of patients: the site discovered on endoscopy was hypopharyngeal in 2 out of 3 cases; the tumour was classified T1 or T2 in 95.5% of cases. Patients treated simultaneously for all sites had a better prognosis than patients in whom each tumour was treated separately. The 5-year specific survival was 34% and the 5-year overall survival was 28%.
  
  
  CONCLUSIONS
  The prevalence of simultaneous squamous cell carcinomas of the oral cavity and hypopharynx ranges between 1 to 7.4% in the literature and was 4.6% in the present series. A common treatment strategy for each of the patient's tumours appears to be superior to the current theoretical approach that consists of considering each tumour separately.
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHU d'Amiens, Centre Hospitalier Nord, place Victor-Pauchet, 80054 Amiens cedex, France. Electronic address: boutepic@hotmail.com.
authors.forename: P
authors.initials: P
authors.lastname: Boute
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHU d'Amiens, Centre Hospitalier Nord, place Victor-Pauchet, 80054 Amiens cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Page
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHU d'Amiens, Centre Hospitalier Nord, place Victor-Pauchet, 80054 Amiens cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Biet
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHU d'Amiens, Centre Hospitalier Nord, place Victor-Pauchet, 80054 Amiens cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Cuvelier
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHU d'Amiens, Centre Hospitalier Nord, place Victor-Pauchet, 80054 Amiens cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Strunski
authors.affiliation: Service d'ORL et chirurgie cervico-faciale, CHRU, 2, avenue Oscar-Lambret, 59037 Lille cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Chevalier
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004724:Endoscopy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D009378:Neoplasms, Multiple Primary / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D010166:Palliative Care; D012189:Retrospective Studies
keywords: Endoscopy; Head and neck cancer; Multiple primary cancers; Second primary tumour