title: Recommendations for donor human leukocyte antigen assessment and matching for allogeneic stem cell transplantation: consensus opinion of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN).
abstract: The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) conducts large, multi-institutional clinical trials with the goal of improving the outcomes of hematopoietic cell transplantation (HCT) for patients with life-threatening disorders. Well-designed HCT trials benefit from standardized criteria for defining diagnoses, treatment plans, and graft source selection. In this perspective, we summarize evidence supporting criteria for the selection of related and unrelated adult volunteer progenitor cell donors or umbilical cord blood units. These standardized criteria for graft source selection have been adopted by the BMT CTN to enhance the interpretation of clinical findings within and among future clinical protocols.
authors.affiliation: Immunobiology Research, Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
authors.forename: C Alan
authors.initials: CA
authors.lastname: Howard
authors.affiliation: Department of Pathology, Stanford Medical School Blood Center, Stanford, California.
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Fernandez-Vina
authors.affiliation: Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Frederick R
authors.initials: FR
authors.lastname: Appelbaum
authors.affiliation: Immunobiology Research, Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota; National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
authors.affiliation: Blood and Marrow Transplant Program, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
authors.forename: Steven M
authors.initials: SM
authors.lastname: Devine
authors.affiliation: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Mary M
authors.initials: MM
authors.lastname: Horowitz
authors.affiliation: The EMMES Corporation, Rockville, Maryland.
authors.forename: Adam
authors.initials: A
authors.lastname: Mendizabal
authors.affiliation: Division of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, California.
authors.forename: Ginna G
authors.initials: GG
authors.lastname: Laport
authors.affiliation: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Marcelo C
authors.initials: MC
authors.lastname: Pasquini
authors.affiliation: Immunobiology Research, Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota. Electronic address: sspellma@nmdp.org.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Spellman
mesh_terms: D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D036101:Cord Blood Stem Cell Transplantation; D006680:HLA Antigens / Q000032:analysis*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing / Q000592:standards*; D006801:Humans; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens
keywords: Allogeneic transplantations; Cord blood donor; Recipient; Related donor; Unrelated donor