title: The circulating level of leptin and blood pressure in patients with multiple system atrophy.
abstract: Patients with multiple system atrophy (MSA) frequently exhibit orthostatic hypotension (OH). Leptin, an adipose-derived hormone, contributes to the sympathetic control of blood pressure (BP), and loss of leptin may cause OH. We aimed to clarify the relationship between leptin and OH in MSA. Serum leptin levels were measured in 36 patients with MSA, 25 patients with other atypical parkinsonian disorders (APDs), including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome, and 26 control subjects. Blood samples were obtained after fasting for 12h. In MSA patients, baseline BP was measured in the recumbent position after a 3-min rest, and orthostatic changes in BP were evaluated after 0-3 min of standing. Serum leptin levels did not differ significantly between MSA patients (5.9 ± 0.8 ng/ml), other APD patients (5.2 ± 0.8 ng/ml), and controls (6.1 ± 1.3 ng/ml; P=0.8). In MSA patients, serum leptin levels correlated significantly with body mass index (P=0.01), but not baseline BPs (systolic BP, P=0.20; diastolic BP, P=0.44) or orthostatic drop in BP (systolic BP, P=0.13; diastolic BP, P=0.58). Our observations indicated that the circulating level of leptin was preserved, and OH occurred independent of the leptin level in MSA patients.
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan. Electronic address: ozawa@bri.niigata-u.ac.jp.
authors.forename: Tetsutaro
authors.initials: T
authors.lastname: Ozawa
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Tokunaga
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
authors.forename: Musashi
authors.initials: M
authors.lastname: Arakawa
authors.affiliation: Department of Neurology, Brain Disease Center Agano Hospital, 6317-15 Yasuda, Agano, Niigata 959-2221, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishikawa
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Takeuchi
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Yokoseki
authors.affiliation: Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine, 1 Asahimachi-dori, Chuoku, Niigata 951-8510, Japan.
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.affiliation: Department of Neurology, Brain Research Institute, Niigata University, 1-757 Asahimachi-dori, Chuoku, Niigata 951-8585, Japan.
authors.forename: Masatoyo
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D000368:Aged; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000503:physiopathology; D001794:Blood Pressure; D005260:Female; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D010300:Parkinson Disease / Q000097:blood / Q000503:physiopathology; D013494:Supranuclear Palsy, Progressive / Q000097:blood / Q000503:physiopathology
chemical_list: D020738:Leptin
keywords: Autonomic dysfunction; Corticobasal syndrome; Leptin; Multiple system atrophy; Orthostatic hypotension; Progressive supranuclear palsy