title: Sc(OTf)3-catalyzed transfer diazenylation of 1,3-dicarbonyls with triazenes via N-N bond cleavage.
abstract: A new and efficient method for diazenylation reactions was developed with a Sc(OTf)3-catalyzed nitrogen-nitrogen bond cleavage process with triazenes. The transfer diazenylation reactions accommodate a diverse range of active methylene substrates including simple ketones to give aliphatic azo compounds that are of significant potential as azo prodrugs in high yields under mild conditions.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Lv
authors.forename: Sanzhong
authors.initials: S
authors.lastname: Luo
authors.forename: Jin-Pei
authors.initials: JP
authors.lastname: Cheng
mesh_terms: D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D012538:Scandium / Q000737:chemistry*; D014226:Triazenes / Q000737:chemistry*
chemical_list: D007659:Ketones; D008698:Mesylates; D014226:Triazenes; C436603:scandium triflate; D009584:Nitrogen; D012538:Scandium