title: Varus deformity of the left lower extremity causing degenerative lesion of the posterior horn of the left medial meniscus in a patient with Paget's disease of bone.
abstract: We report on a 42-year-old woman who presented with persistent pain in her left knee with no history of trauma. Sagittal T1-weighted MRI of the left knee showed discontinuity between the anterior and posterior horns of the left medial meniscus, causing effectively the development of degenerative lesion of the posterior horn. The latter was correlated to varus deformity of the left lower extremity associated with subsequent narrowing of the medial knee joint. The unusual craniofacial contour of the patient, the skeletal survey and the elevated serum alkaline phosphatase were compatible with the diagnosis of Paget's disease of the bone. To alleviate the adverse effect of the mal-alignment of the left femur onto the left knee, corrective osteotomy of the left femoral diaphysis by means of fixators was performed. To the best of our knowledge this is the first clinical report describing the management and the pathological correlation of a unilateral varus deformity of the femoral shaft and degenerative lesions of the left knee in a patient with Paget's disease of the bone.
authors.affiliation: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital, Vienna, Austria ; Orthopaedic Hospital of Speising, Paediatric Department, Vienna, Austria.
authors.forename: Ali
authors.initials: A
authors.lastname: Al Kaissi
authors.affiliation: Orthopaedic Hospital of Speising, Paediatric Department, Vienna, Austria.
authors.forename: Rudolf
authors.initials: R
authors.lastname: Ganger
authors.affiliation: Orthopaedic Hospital of Speising, Paediatric Department, Vienna, Austria.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Mindler
authors.affiliation: Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, First Medical Department, Hanusch Hospital, Vienna, Austria.
authors.forename: Klaus
authors.initials: K
authors.lastname: Klaushofer
authors.affiliation: Orthopaedic Hospital of Speising, Paediatric Department, Vienna, Austria.
authors.forename: Franz
authors.initials: F
authors.lastname: Grill
mesh_terms: D000328:Adult; D060905:Coxa Vara / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D005269:Femur / Q000473:pathology / Q000601:surgery; D006801:Humans; D007719:Knee Joint / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008592:Menisci, Tibial / Q000473:pathology*; D010001:Osteitis Deformans / Q000150:complications* / Q000473:pathology / Q000601:surgery; D010027:Osteotomy
keywords: Paget's disease of bone; degenerative lesion of medial meniscus; radiology; varus deformity