title: Saliva-based biosensors: noninvasive monitoring tool for clinical diagnostics.
abstract: Saliva is increasingly recognised as an attractive diagnostic fluid. The presence of various disease signalling salivary biomarkers that accurately reflect normal and disease states in humans and the sampling benefits compared to blood sampling are some of the reasons for this recognition. This explains the burgeoning research field in assay developments and technological advancements for the detection of various salivary biomarkers to improve clinical diagnosis, management, and treatment. This paper reviews the significance of salivary biomarkers for clinical diagnosis and therapeutic applications, with focus on the technologies and biosensing platforms that have been reported for screening these biomarkers.
authors.affiliation: Faculty of Biosciences and Medical Engineering (FBME), Universiti Teknologi Malaysia, Building VO1, Block A, Level 5, Room 27, 81310 Skudai, Johor, Malaysia.
authors.forename: Radha S P
authors.initials: RS
authors.lastname: Malon
authors.affiliation: Faculty of Mechanical Engineering (FKM), Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.
authors.forename: Sahba
authors.identifier: 0000-0001-7252-0353
authors.initials: S
authors.lastname: Sadir
authors.affiliation: Faculty of Biosciences and Medical Engineering (FBME), Universiti Teknologi Malaysia, Building VO1, Block A, Level 5, Room 27, 81310 Skudai, Johor, Malaysia.
authors.forename: Malarvili
authors.initials: M
authors.lastname: Balakrishnan
authors.affiliation: Faculty of Biosciences and Medical Engineering (FBME), Universiti Teknologi Malaysia, Building VO1, Block A, Level 5, Room 27, 81310 Skudai, Johor, Malaysia.
authors.forename: Emma P
authors.initials: EP
authors.lastname: Córcoles
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D019937:Diagnostic Techniques and Procedures; D006801:Humans; D008991:Monitoring, Physiologic / Q000379:methods*; D012463:Saliva / Q000737:chemistry* / Q000201:enzymology; D012468:Salivary Gland Neoplasms / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor