title: Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?
abstract: Primary sinonasal intestinal-type adenocarcinomas (ITAC) are defined on the basis of their morphological similarities to colorectal adenocarcinomas (CRA). Thus, differential diagnosis with sinonasal metastasis of CRA could be a real challenge. Neuroendocrine differentiation has been variably described in several types of adenocarcinomas and notably in ITACs and CRAs. In a series of 25 ITACs and 25 lymph node metastasis of CRAs (nmCRA), we analysed neuroendocrine differentiation by immunohistochemistry with anti-chromogranin A and synaptophysin antibodies. Neuroendocrine differentiation (chromogranin A and/or synaptophysin positivity) was significantly different (p=0.0002) in ITACs (72%) and in nmCRAs (20%). In conclusion, presence of neuroendocrine cells seems more in favour of a sinonasal intestinal-type adenocarcinoma, than metastatic CRA. This immunohistochemical study could be useful in difficult cases and should be an interesting complement in a clinical discussion.
authors.affiliation: Department of Pathology, Universitary Institute of Cancer, Toulouse, France Rangueil medical university, Toulouse, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Projetti
authors.affiliation: Rangueil medical university, Toulouse, France Department of Otorhinolaryngology-Head and Neck Surgery, Rangueil-Larrey University Hospital, Toulouse, France.
authors.forename: Elie
authors.initials: E
authors.lastname: Serrano
authors.affiliation: Rangueil medical university, Toulouse, France Department of Otorhinolaryngology-Head and Neck Surgery, Universitary Institute of Cancer, Toulouse, France.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Vergez
authors.affiliation: Department of Pathology, Universitary Institute of Cancer, Toulouse, France Rangueil medical university, Toulouse, France.
authors.forename: Anne-Charlotte
authors.initials: AC
authors.lastname: Bissainthe
authors.affiliation: Department of Pathology, Universitary Institute of Cancer, Toulouse, France Department of Pathology, Rangueil University Hospital, Toulouse, France.
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
authors.affiliation: Department of Pathology, Universitary Institute of Cancer, Toulouse, France Rangueil medical university, Toulouse, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uro-Coste
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000556:secondary; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D053379:Chromogranin A / Q000032:analysis; D015179:Colorectal Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000556:secondary; D016708:Synaptophysin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D053379:Chromogranin A; C569014:SYP protein, human; D016708:Synaptophysin
keywords: HEAD AND NECK CANCER; IMMUNOHISTOCHEMISTRY; Neuroendocrine