title: Evaluation of the retinal ganglion cell layer thickness in healthy Turkish children.
abstract: OBJECTIVE
  To identify the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children measured by high-definition optical coherence tomography (HD-OCT).
  
  
  METHODS
  This institutional study involved 296 eyes from 296 healthy children aged between 3 and 17 years. Each child underwent a dilated eye examination, cycloplegic refraction, and axial length measurement using Nidek AL-Scan optical biometer. Macular scan was used to measure the GC-IPL thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness was measured using the HD-OCT (Cirrus HD-OCT). Right eye of each subject was selected for analysis.
  
  
  RESULTS
  A total of 296 children (125 boys, 171 girls) were included in this study. The mean age of the children was 9.62±4.10 years (range, 3 to 17 y). The mean spherical equivalent was -0.09±1.49 D. The mean AL was 23.03±1.03 mm. The mean overall GC-IPL thickness was 83.44±5.52 μm and RNFL thickness was 96.91±10.21 μm. They were thicker than has been reported in adults. According to age-adjusted multiple regression analyses significant predictors of mean GC-IPL thickness were peripapillary RNFL thickness and AL (P<0.001).
  
  
  CONCLUSIONS
  This study ensures a pediatric normative database of GC-IPL using spectral-domain OCT. This information may provide to diagnosis and monitoring of optic nerve diseases and glaucoma in children.
authors.affiliation: Department of Ophthalmology, Turgut Özal University, Medical School, Ankara, Turkey.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Totan
authors.forename: Fatma B
authors.initials: FB
authors.lastname: Gürağaç
authors.forename: Emre
authors.initials: E
authors.lastname: Güler
mesh_terms: D000293:Adolescent; D000367:Age Factors; D058452:Axial Length, Eye / Q000033:anatomy & histology; D002648:Child; D002675:Child, Preschool; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D009412:Nerve Fibers; D009929:Organ Size; D011446:Prospective Studies; D012016:Reference Values; D012029:Refraction, Ocular / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000166:cytology*; D012737:Sex Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014421:Turkey