title: Inflamm-aging: STAT3 signaling pushes muscle stem cells off balance.
abstract: Two recent studies shed light on mechanisms underlying muscle dysfunction in age and disease. They reveal that JAK-STAT signaling regulates myogenic differentiation, leading to a reduced reservoir of muscle stem cells. Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.
authors.affiliation: Center of Genetics and Molecular and Cellular Physiology - CNRS UMR5534, Université Lyon 1 Claude Bernard, 69100 Villeurbanne, France. Electronic address: benedicte.chazaud@inserm.fr.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Chazaud
authors.affiliation: Center of Genetics and Molecular and Cellular Physiology - CNRS UMR5534, Université Lyon 1 Claude Bernard, 69100 Villeurbanne, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Mouchiroud
mesh_terms: D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D006801:Humans; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology*