title: Fibromyalgia patients had normal distraction related pain inhibition but cognitive impairment reflected in caudate nucleus and hippocampus during the Stroop Color Word Test.
abstract: The mechanisms causing cognitive problems in chronic pain patients are not well understood. We used the Stroop color word task (SCWT) to investigate distraction-induced analgesia, cognitive performance, and cerebral activation patterns in 29 fibromyalgia (FM) patients (mean age 49.8 years, range 25-64 years) and 31 healthy controls (HC) (mean age 46.3 years, range 20-63 years). In the first study, SCWT was used to investigate distraction-induced analgesia in FM patients. Two versions of the task were applied, one with only congruent color-word images and one with incongruent images. Pressure pain thresholds were assessed using a pressure algometer before, during, and following SCWT. In the second study, reaction times (RTs) were assessed and functional magnetic resonance imaging (fMRI) was used to investigate cerebral activation patterns in FM patients and HC during the SCWT. An event-related task mixing incongruent and congruent images was used. In study one, we found reduced pressure pain sensitivity during SCWT in both groups alike and no statistically significant differences were seen between the incongruent and congruent conditions. The study two revealed longer RTs during the incongruent compared to the congruent condition in both groups. FM patients had longer RTs than HC in both conditions. Furthermore, we found a significant interaction between group and congruency; that is, the group differences in RTs were more pronounced during the incongruent condition. This was reflected in a reduced activation of the caudate nucleus, lingual gyrus, temporal areas, and the hippocampus in FM patients compared to HC. In conclusion, we found normal pain inhibition during SWTC in FM patients. The cognitive difficulties seen in FM patients, reflected in longer RTs, were related to reduced activation of the caudate nucleus and hippocampus during incongruent SCWT, which most likely affected the mechanisms of cognitive learning in FM patients.
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Sofia
authors.initials: S
authors.lastname: Martinsen
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Pär
authors.initials: P
authors.lastname: Flodin
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Berrebi
authors.affiliation: Dept. of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden.
authors.forename: Monika
authors.initials: M
authors.lastname: Löfgren
authors.affiliation: Dept. of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Danderyd, Sweden.
authors.forename: Indre
authors.initials: I
authors.lastname: Bileviciute-Ljungar
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Martin
authors.initials: M
authors.lastname: Ingvar
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Peter
authors.initials: P
authors.lastname: Fransson
authors.affiliation: Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Eva
authors.initials: E
authors.lastname: Kosek
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D001931:Brain Mapping; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000503:physiopathology*; D003072:Cognition Disorders / Q000503:physiopathology*; D015331:Cohort Studies; D005260:Female; D005356:Fibromyalgia / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D057190:Stroop Test; D055815:Young Adult