title: Lanthanide nano-drums: a new class of molecular nanoparticles for potential biomedical applications.
abstract: We are developing a new class of lanthanide-based self-assembling molecular nanoparticles as potential reporter molecules for imaging, and as multi-functional nanoprobes or nanosensors in diagnostic systems. These lanthanide "nano-drums" are homogeneous 4d-4f clusters approximately 25 to 30 Å in diameter that can emit from the visible to near-infrared (NIR) wavelengths. Here, we present syntheses, crystal structures, photophysical properties, and comparative cytotoxicity data for six nano-drums containing either Eu, Tb, Lu, Er, Yb or Ho. Imaging capabilities of these nano-drums are demonstrated using epifluorescence, total internal reflection fluorescence (TIRF), and two-photon microscopy. We discuss how these molecular nanoparticles can to be adapted for a range of assays, particularly by taking advantage of functionalization strategies with chemical moieties to enable conjugation to protein or nucleic acids.
authors.affiliation: Department of Chemistry, The University of Texas at Austin, 105 E. 24th St. Stop A5300, Austin, Texas 78712, USA. rajones@cm.utexas.edu.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jones
authors.forename: Annie J
authors.initials: AJ
authors.lastname: Gnanam
authors.forename: Jonathan F
authors.initials: JF
authors.lastname: Arambula
authors.forename: Jessica N
authors.initials: JN
authors.lastname: Jones
authors.forename: Jagannath
authors.initials: J
authors.lastname: Swaminathan
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Yang
authors.forename: Desmond
authors.initials: D
authors.lastname: Schipper
authors.forename: Justin W
authors.initials: JW
authors.lastname: Hall
authors.forename: Lauren J
authors.initials: LJ
authors.lastname: DePue
authors.forename: Yakhya
authors.initials: Y
authors.lastname: Dieye
authors.forename: Jamuna
authors.initials: J
authors.lastname: Vadivelu
authors.forename: Don J
authors.initials: DJ
authors.lastname: Chandler
authors.forename: Edward M
authors.initials: EM
authors.lastname: Marcotte
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Sessler
authors.forename: Lauren I R
authors.initials: LI
authors.lastname: Ehrlich
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Brown
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D035843:Biomedical Research; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D050997:Nanomedicine; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds