title: Is immunological tolerance (non-responsiveness) a consequence of interleukin 2 deficit during the recognition of antigen?
abstract: There have been recent demonstrations that immunological tolerance can be MHC-restricted. The same antigen, therefore, can be recognized in the context of an appropriate MHC molecule both as an antigen andas a tolerogen. Here Miroslav Malkovský and Peter Medawar propose that the outcome of the encounter is determined by the availability or effectiveness of interleukin 2. If there is a deficit of the hormone, unresponsiveness is promoted in the T cells which recognize the antigen.
authors.affiliation: Clinical Research Centre, Harrow, Middlesex HA1 3UJ, UK.
authors.forename: M
authors.initials: M
authors.lastname: Malkovský
authors.forename: P B
authors.initials: PB
authors.lastname: Medawar