title: Clinical profile of uveitis-related ocular hypertension.
abstract: The purpose of this article is to study the clinical and demographic profile of uveitis-related ocular hypertension (OHT) and evaluate risk factors predisposing to development of OHT in uveitis. Two hundred patients (200 eyes) with uveitis were evaluated for type of uveitis and the presence of OHT [IOP > 21 mmHg]. All patients underwent a complete ophthalmic examination and appropriate systemic evaluation. Patients with OHT were started on appropriate antiglaucoma medication and were followed up for minimum of 6 months. Forty-two eyes (21 %) were found to have OHT. Anterior uveitis alone was seen in 22 (52.4 %), granulomatous uveitis was seen in 8 (19.1 %) eyes, while 13 eyes (30.9 %) had active uveitis. On multiple logistic regression, age greater than 60 years (p = 0.025), peripheral anterior synechiae (PAS) > 180° (p = 0.029), and steroid use (p < 0.001) were found to have significant association with OHT. Mean IOP at baseline was 24.6 ± 10.1 mmHg which decreased to 17.3 ± 4.5 mmHg at 6 months (p < 0.001). At 6 months, 30 eyes were medically controlled (71.4 %), 5 eyes underwent trabeculectomy with MMC (11.9 %), and in 7 eyes, antiglaucoma medication could be discontinued. One-fifth of eyes with uveitis had OHT. Risk factors for IOP elevation included increased age, PAS > 180°, and corticosteroid use.
authors.affiliation: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Room No. S1, 1st Floor, New Delhi, 110029, India.
authors.forename: Deepankur
authors.initials: D
authors.lastname: Mahajan
authors.forename: Reetika
authors.initials: R
authors.lastname: Sharma
authors.forename: Sat Pal
authors.initials: SP
authors.lastname: Garg
authors.forename: Pradeep
authors.initials: P
authors.lastname: Venkatesh
authors.forename: Ramanjit
authors.initials: R
authors.lastname: Sihota
authors.forename: Tanuj
authors.initials: T
authors.lastname: Dada
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D014605:Uveitis / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents