title: eRNAs lure NELF from paused polymerases.
abstract: RNAs transcribed from enhancers (eRNAs) have been linked to enhancer function. In this issue of Molecular Cell, Schaukowitch et al. (2014) show that upon activation, eRNAs can bind NELF and are necessary for its transient removal from promoters to release paused RNA polymerase II and drive expression of immediate-early genes in neurons.
authors.affiliation: Molecular Cell, Cell Press, 600 Technology Square, 5th Floor, Cambridge, MA 02139, USA. Electronic address: bplosky@cell.com.
authors.forename: Brian S
authors.initials: BS
authors.lastname: Plosky
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D008957:Models, Genetic; D062085:RNA, Long Noncoding / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
chemical_list: C582413:NELF protein, mouse; D062085:RNA, Long Noncoding; D014157:Transcription Factors