title: Effects of weight gain induced by controlled overfeeding on physical activity.
abstract: It is unclear whether physical activity changes following long-term overfeeding and in response to different dietary protein intakes. Twenty-five (16 males, 9 females) healthy adults (18-35 yr) with BMI ranging from 19 to 30 kg/m(2) enrolled in this inpatient study. In a parallel group design, participants were fed 140% of energy needs, with 5, 15, or 25% of energy from protein, for 56 days. Participants wore an RT3 accelerometer for at least 59 days throughout baseline and during overfeeding and completed 24-h whole room metabolic chamber assessments at baseline and on days 1, 14, and 56 of overfeeding and on day 57, when the baseline energy intake was consumed, to measure percent of time active and spontaneous physical activity (SPA; kcal/day). Changes in activity were also assessed by doubly labeled water (DLW). From accelerometry, vector magnitude (VM), a weight-independent measure of activity, and activity energy expenditure (AEE) increased with weight gain during overfeeding. AEE remained increased after adjusting for changes in body composition. Activity-related energy expenditure (AREE) from DLW and percent activity and SPA in the metabolic chamber increased with overfeeding, but SPA was no longer significant after adjusting for change in body composition. Change in VM and AEE were positively correlated with weight gain; however, change in activity was not affected by protein intake. Overfeeding produces an increase in physical activity and in energy expended in physical activity after adjusting for changes in body composition, suggesting that increased activity in response to weight gain might be one mechanism to support adaptive thermogenesis.
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana John.Apolzan@pbrc.edu.
authors.forename: John W
authors.initials: JW
authors.lastname: Apolzan
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: George A
authors.initials: GA
authors.lastname: Bray
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Lilian
authors.initials: L
authors.lastname: de Jonge
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Rood
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Han
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Leanne M
authors.initials: LM
authors.lastname: Redman
authors.affiliation: Pennington Biomedical Research Center, Baton Rouge, Louisiana.
authors.forename: Corby K
authors.initials: CK
authors.lastname: Martin
mesh_terms: D001823:Body Composition / Q000502:physiology; D018753:Diet, Protein-Restricted; D004044:Dietary Proteins / Q000494:pharmacology; D004311:Double-Blind Method; D004435:Eating / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D010101:Oxygen Consumption / Q000502:physiology; D015430:Weight Gain / Q000502:physiology*
chemical_list: D004044:Dietary Proteins
keywords: doubly labeled water; energy expenditure; metabolic chamber; obesity; spontaneous physical activity