title: Environmentally friendly method for the determination of acrylamide and trimethylolpropane in paper packaging materials by liquid chromatography with tandem mass spectrometry.
abstract: A simple, rapid, and environmentally friendly method was developed for the determination of acrylamide and trimethylolpropane in paper packaging materials. No organic solvent was used and the matrix effect was investigated. The extract was directly analyzed by liquid chromatography with tandem mass chromatography for quantification and confirmation. The chromatographic separations were performed on a ZORBAX HILIC Plus (2.1 mm × 150 mm, 3μm; Agilent, USA) column with only one mobile phase (100% water). Calibration curves for acrylamide and trimethylopropane were achieved with concentrations ranging from 0.4 to 20 mg/kg and the corresponding r(2) values were 0.998 and 0.999, respectively. The recoveries were >85% with relative standard deviations <10%. The validated method was applied to the analysis of 50 real samples, and positive results were obtained for 30 samples. The result indicated that trimethylolpropane is associated with inks and printing activity and acrylamide is widely used as a papermaking additive in many paper packages. The concentrations of acrylamide and trimethylolpropane ranged from 0.41 to 7.5 and 0.50 to 8.8 mg/kg, respectively. The results of this study revealed that this method could be used accurately and precisely.
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou, P. R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Zhonghao
authors.initials: Z
authors.lastname: Li
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bian
authors.forename: Gangling
authors.initials: G
authors.lastname: Tang
authors.forename: Ziyan
authors.initials: Z
authors.lastname: Fan
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: ShanShan
authors.initials: S
authors.lastname: Liu
authors.forename: Hongfei
authors.initials: H
authors.lastname: Zhang
mesh_terms: D020106:Acrylamide / Q000032:analysis*; D002853:Chromatography, Liquid; D018857:Food Packaging; D010209:Paper; D011409:Propylene Glycols / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D011409:Propylene Glycols; C018163:trimethylolpropane; D020106:Acrylamide
keywords: Acrylamide; Liquid chromatography; Tandem mass spectrometry; Trimethylolpropane