title: The role of T-cell receptor α and β genes in MHC-restricted antigen recognition.
abstract: T cells use α- and β-chain genes, which are organized and diversified by somatic DNA rearrangements much like the immunoglobulin genes, to encode clonally distributed receptor molecules which confer specificity for MHC and antigen. Here Zlatko Dembic and his colleagues summarize recent mutagenesis and gene transfection experiments indicating that α- and β-chain genes are necessary and sufficient for T-cell specificity.
authors.affiliation: Basel Institute for Immunology, Basel, Switzerland.
authors.forename: Z
authors.initials: Z
authors.lastname: Dembić
authors.forename: H
authors.initials: H
authors.lastname: von Boehmer
authors.forename: M
authors.initials: M
authors.lastname: Steinmetz