title: Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention.
abstract: OBJECTIVE
  The purpose of this study was to investigate the associated between serum total bilirubin (STB) levels and long-term outcomes in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI).
  
  
  METHODS
  A total of 1,273 consecutive patients were enrolled. Patients were grouped according to their baseline STB levels: Group 1 (STB < 3.4 μmol/L), Group 2 (3.4 μmol/L ≤ STB ≤ 10.3 μmol/L), Group 3 (10.3 μmol/L < STB ≤ 17.1 μmol/L), and Group 4 (STB < 17.1 μmol/L) and the rate of major adverse cardiovascular events (MACE) was determined
  
  
  RESULTS
  A total of 1,152 patients were successfully followed up (90.5%) for a mean period of 30 ± 5 months, including 187 patients experiencing a major adverse cardiovascular event (MACE: death from any cause, myocardial infarction, repeat revascularization or readmission). The MACE rate in Groups 3 and 4 was lower than in Groups 1 and 2 (P < 0.01). After adjusted the confounding factors with Cox regression analysis, the MACE rates in Groups 2-4 were still lower than in Group 1 (Group 2, RR=0.293, 95% CI 0.167-0.517, P < 0.01; Group 3, RR=0.142, 95% CI 0.065-0.312, P < 0.01; Group 4, RR=0.134, 95% CI 0.071-0.252, P < 0.01). The cumulative survival rates of Groups 3 and 4 were higher than that of Groups 1and 2 (P < 0.01).
  
  
  CONCLUSIONS
  High STB concentration is associated with lower MACE in patients with ACS after PCI.
authors.affiliation: . email@email.com.
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Tong-Wen
authors.initials: TW
authors.lastname: Sun
authors.forename: Quan-Cheng
authors.initials: QC
authors.lastname: Kan
authors.forename: Hai-Mu
authors.initials: HM
authors.lastname: Yao
authors.forename: You-Dong
authors.initials: YD
authors.lastname: Wan
authors.forename: Rui
authors.initials: R
authors.lastname: Yao
authors.forename: Fang-Xia
authors.initials: FX
authors.lastname: Guan
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Guo
authors.forename: Shu-Guang
authors.initials: SG
authors.lastname: Zhang
authors.forename: Wen-Ju
authors.initials: WJ
authors.lastname: Sun
authors.forename: Le-Xin
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D001663:Bilirubin