title: Animal models of bronchopulmonary dysplasia. The preterm baboon models.
abstract: Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features associated with this model not fully discussed in this limited forum. We also describe efforts to incorporate perinatal infection into these preterm models, both fetal and neonatal, and particularly associated with Ureaplasma/Mycoplasma organisms. Efforts to rekindle the preterm primate model for future evaluations of therapies such as stem cell replacement, early lung recruitment interventions coupled with noninvasive surfactant and high-frequency nasal ventilation, and surfactant therapy coupled with antioxidant or anti-inflammatory medications, to name a few, should be undertaken.
authors.affiliation: Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah; and bradley.yoder@hsc.utah.edu.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Yoder
authors.affiliation: Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.
authors.forename: Jacqueline J
authors.initials: JJ
authors.lastname: Coalson
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D010215:Papio; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012121:Respiration, Artificial; D014509:Ureaplasma; D016869:Ureaplasma Infections / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D011663:Pulmonary Surfactants
keywords: baboon; bronchopulmonary dysplasia; lung; preterm infant; ureaplasma