title: [The role of biomarkers in the diagnostics of acute mesenteric ischemia].
abstract: Acute mesenteric ischemia is a severe and challenging disease. Unspecific symptoms in the initial phase make a fast diagnosis difficult although it is of major importance to protect patients from irreversible ischemia, extended bowel resection, sepsis and death in the late phase. In contrast to troponin as an early biomarker for cardiac ischemia, a reliable biomarker for acute intestinal ischemia has not yet been identified in the current literature and clinical practice. This would allow the early identification of these critically ill patients in the initial reversible phase of acute intestinal ischemia.This review highlights the pathophysiology, epidemiology and clinical findings of acute mesenteric ischemia and gives an overview of biomarkers which have been investigated in mesenteric ischemia with a special focus on lactate, which is the only parameter routinely used in the diagnostic setting of acute mesenteric ischemia.
authors.affiliation: Klinik für Allgemein-, Viszeral-, Thorax-, Transplantations- und Kinderchirurgie, Universitätsklinik Gießen und Marburg GmbH, Standort Gießen, Rudolf Buchheim Str. 7, 35392, Gießen, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Reichert
authors.forename: M
authors.initials: M
authors.lastname: Hecker
authors.forename: R
authors.initials: R
authors.lastname: Hörbelt
authors.forename: S
authors.initials: S
authors.lastname: Lerner
authors.forename: J
authors.initials: J
authors.lastname: Höller
authors.forename: C M
authors.initials: CM
authors.lastname: Hecker
authors.forename: W
authors.initials: W
authors.lastname: Padberg
authors.forename: M A
authors.initials: MA
authors.lastname: Weigand
authors.forename: A
authors.initials: A
authors.lastname: Hecker
mesh_terms: D000208:Acute Disease; D015415:Biomarkers / Q000097:blood*; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D065666:Mesenteric Ischemia / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology*; D011237:Predictive Value of Tests
chemical_list: D015415:Biomarkers; D019344:Lactic Acid