title: Plasminogen activator inhibitor-1 as an early potential diagnostic marker for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is the most common cause of dementia in individuals over 65 years old. However, to date, no useful early diagnostic markers for AD have been discovered. We examined the utility of plasminogen activator inhibitor-1 (PAI-1) as a potential biomarker for AD in subjects with mild cognitive impairment (MCI) or AD, as well as in nondemented healthy controls. Plasma PAI-1 levels were measured by enzyme-linked immunosorbent assays (ELISAs) in samples collected from 76 patients with MCI, 74 patients with AD, and 76 healthy controls. Our results show that plasma PAI-1 levels gradually increased as dementia progressed. The mean levels of plasma PAI-1 in patients with MCI and AD patients were significantly higher than those of in healthy controls. Consistently, neuropsychological examination (e.g., MMSE, CDR) also demonstrated significant correlations between the plasma PAI-1 levels and cognitive function. In conclusion, the level of plasma PAI-1 is a potential biomarker for the early detection and diagnosis of AD.
authors.affiliation: Division of Brain Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong, Chungcheongbuk-do 361-951, South Korea.
authors.forename: Jaeho
authors.initials: J
authors.lastname: Oh
authors.affiliation: Division of Metabolic Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong, Chungcheongbuk-do 361-951, South Korea.
authors.forename: Hye-Ja
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: Division of Brain Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong, Chungcheongbuk-do 361-951, South Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Song
authors.affiliation: Division of Brain Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong, Chungcheongbuk-do 361-951, South Korea. Electronic address: parksi61@hotmail.com.
authors.forename: Sang Ick
authors.initials: SI
authors.lastname: Park
authors.affiliation: Division of Brain Diseases, Center for Biomedical Science, Korea National Institute of Health, Osong, Chungcheongbuk-do 361-951, South Korea. Electronic address: inbiology@naver.com.
authors.forename: Hyunyoung
authors.initials: H
authors.lastname: Kim
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000235:genetics / Q000523:psychology; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis* / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D015153:Blotting, Western; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D018450:Disease Progression; D042241:Early Diagnosis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human
keywords: Alzheimer's disease; Diagnostic marker; Mild cognitive impairment; Plasminogen activator inhibitor 1