title: Neonatal thrombocytopenia and platelet transfusion - a UK perspective.
abstract: Five percent of newborn infants admitted to UK neonatal units during a recent study developed a platelet count <60 × 10(9)/l, and 60% of these were transfused platelets. This review summarises the common causes and mechanisms of thrombocytopenia in the newborn. Relevant evidence relating the platelet count to the risk of haemorrhage is reviewed, and current UK guidance on transfusion thresholds outlined. The UK policy for the provision of platelets for transfusion to neonates is described, including the particular requirements for neonatal allo-immune thrombocytopenia. Finally, we look towards the future and prospects for reducing the need to expose newborns to donor-derived platelets.
authors.affiliation: Department of Haematology, Guy's and St Thomas' Hospital, King's College London, London, UK.
authors.forename: Robert
authors.initials: R
authors.lastname: Carr
authors.forename: Anne M
authors.initials: AM
authors.lastname: Kelly
authors.forename: Lorna M
authors.initials: LM
authors.lastname: Williamson
mesh_terms: D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D020380:Needs Assessment; D010976:Platelet Count / Q000379:methods; D017713:Platelet Transfusion / Q000379:methods*; D017410:Practice Guidelines as Topic; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood / Q000209:etiology / Q000628:therapy; D006113:United Kingdom