title: Primary Rosai-Dorfman disease of the bone in a patient with history of breast cancer: appearance on 99mTc-MDP scintigraphy, CT, and X-ray.
abstract: A 49-year-old woman with history of breast cancer presented with pain at the level of the left anterior proximal tibia. An x-ray of the tibia demonstrated a lytic cortical lesion that prompted a whole-body 99mTc-MDP bone scan. The bone scan revealed intense bone remodeling at the level of the tibial lytic lesion and in the cervical spine. CT demonstrated an expansile lesion eroding the vertebral bodies of C6 and C7 with a large soft tissue component. A biopsy of the cervical spine mass demonstrated features diagnostic of Rosai-Dorfman disease without evidence of neoplastic cells.
authors.affiliation: From the *Department of Radiology, University of Washington, Seattle,WA; †Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY ‡IRCCS Fondazione SDN, Naples, Italy; §Department of Pathology, Western Washington Pathology, Multicare Health System, Tacoma; ∥PhenoPath Laboratories, Seattle; and ¶University of Washington, University of Washington Medical School, Seattle, WA.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Mannelli
authors.forename: Serena
authors.initials: S
authors.lastname: Monti
authors.forename: Jason E
authors.initials: JE
authors.lastname: Love
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kussick
authors.forename: Anna
authors.initials: A
authors.lastname: McLuen
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Behnia
mesh_terms: D001943:Breast Neoplasms / Q000150:complications*; D005260:Female; D015618:Histiocytosis, Sinus / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D013131:Spine / Q000000981:diagnostic imaging* / Q000473:pathology; D013669:Technetium Tc 99m Medronate; D013977:Tibia / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals; D013669:Technetium Tc 99m Medronate