title: [Influence of Kudou Shencha decotion on INF-gamma, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats].
abstract: OBJECTIVE
  To investigate the influence of Kudou Shencha decotion on INF-y, ICAM-1, MCP-1 levels of prostate tissue homogenate in immunity prostatitis model rats.
  
  
  METHODS
  Forty Wistar male rats were divided into 5 groups randomly: Kudou Shencha decotion group with high dosage and low dosage, Qianleitai group, the model control group and normal group. The rat model of chronic nonbacterial prostatitis was established by multiple hypodermical injection of the suspension of prostatic protein purification with Freund's completed adjuvant. The level of intercellular adhesion molecule (ICAM-1), interferon gamma (INF-gamma) and monocyte chemotactic protein-1 (MCP-1) were measured by enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The content of ICAM-1 and MCP-1 in the model group was higher than that of the normal group (P < 0.05), the content of ICAM-1 was obviously decreased in Kudou Shencha decotion group with high dosage (P <0.05), the contents of MCP-1 were all obviously decreased in Kudou Shencha decotion groups and Qianlietai group. Compared with the model group, the contents of INF-gamma in all treatment groups were decreased insignificantly.
  
  
  CONCLUSIONS
  Kudou Shencha decotion has the action of lowering the level of ICAM-1 and MCP-1, which may be one of the mechanisms of Kudou Shencha decotion in the therapy of chronic prostatitis.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Xia
authors.forename: Wei-Jia
authors.initials: WJ
authors.lastname: Liu
authors.forename: Ming-Xi
authors.initials: MX
authors.lastname: Li
authors.forename: Wen-Jin
authors.initials: WJ
authors.lastname: Ge
authors.forename: Xue-Min
authors.initials: XM
authors.lastname: Gao
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism*; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism; D011472:Prostatitis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018932:Chemokine CCL2; D004365:Drugs, Chinese Herbal; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma