title: [Distinct effect of Wansheng Huafeng Dan containing ardisia crenata on renal transporters, mercury accumulation and Kim-1 expression from mercuric chloride].
abstract: To study the effect of Wansheng Huafeng Dan (WSHFD) and mercuric chloride on renal mercury (Hg) extraction transporters (Oat1, Oct2), renal mercury excretion transporters (Mrp4, Mate2K), renal mercury accumulation and kidney injury molecule-1 (Kim-1). The ancient prescription of WSHFD containing 10-fold Hg caused much lower renal mercury accumulation and renal toxicity than HgCl2 in rats, with less effect on renal transporters than HgCl2. The above indicators had no significant difference in WSHFDO, WSHFD2 and WSHFD3 groups, indicating no effect of WSHFD with reduced or no cinnabar.
authors.forename: Qiong-Ni
authors.initials: QN
authors.lastname: Zhu
authors.forename: Yuan-Fu
authors.initials: YF
authors.lastname: Lu
authors.forename: Jing-Zhen
authors.initials: JZ
authors.lastname: Shi
authors.forename: Qin
authors.initials: Q
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Jing-Shan
authors.initials: JS
authors.lastname: Shi
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D031644:Ardisia / Q000737:chemistry*; D001692:Biological Transport / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000235:genetics* / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D015870:Gene Expression / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008627:Mercuric Chloride / Q000378:metabolism*; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015815:Cell Adhesion Molecules; D004365:Drugs, Chinese Herbal; D008627:Mercuric Chloride; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C489542:Abcc4 protein, rat; C110936:Havcr1 protein, rat