title: Mina: a Th2 response regulator meets TGFβ.
abstract: The JmjC protein Mina is an important immune response regulator. Classical forward genetics first discovered its immune role in 2009 in connection with the development of T helper 2 (Th2) cells. This prompted investigation into Mina's role in the two best-studied contexts where Th2 responses are essential: atopic asthma and helminth expulsion. In work focused on a mouse model of atopic asthma, Mina deficiency was found to ameliorate airway hyper-resistance and pulmonary inflammation. And, in a case-control study genetic variation at the human MINA locus was found to be associated with the development of childhood atopic asthma. Although the underlying cellular and molecular mechanism of Mina's involvement in pulmonary inflammation remains unknown, our recent work on parasitic helminth expulsion suggests the possibility that, rather than T cells, epithelial cells responding to TGFβ may play the dominant role. Here we review the growing body of literature on the emerging Mina pathway in T cells and epithelial cells and attempt to set these into a broader context.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Meenu R
authors.initials: MR
authors.lastname: Pillai
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
authors.forename: Shangli
authors.initials: S
authors.lastname: Lian
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Electronic address: mark.bix@stjude.org.
authors.forename: Mark
authors.initials: M
authors.lastname: Bix
mesh_terms: D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D049308:Dioxygenases; D004195:Disease Models, Animal; D056426:Genetic Loci / Q000276:immunology; D014644:Genetic Variation / Q000276:immunology; D006373:Helminthiasis / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D056466:Histone Demethylases; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology; D051379:Mice; D009363:Neoplasm Proteins / Q000235:genetics / Q000276:immunology*; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology* / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology*
chemical_list: C512207:Mina53 protein, mouse; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D016212:Transforming Growth Factor beta; D049308:Dioxygenases; D056466:Histone Demethylases; C466777:RIOX2 protein, human