title: A clinical and pathological variant of acute transplant glomerulopathy.
abstract: Acute transplant glomerulopathy transplant glomerulopathy (TG) is a common cause of late renal allograft loss. We describe a unique case of a renal transplant recipient who developed rapid-onset nephrotic-range proteinuria and acute kidney injury secondary to C4d negative acute TG. Two courses of intravenous Rituximab resulted in significant improvement in proteinuria and allograft function. In the setting of acute nephrotic-range proteinuria postrenal allograft, both renal biopsy with electron microscopy and screening for de novo donor-specific antibody should be performed to distinguish atypical presentations of TG from other diagnoses.
authors.affiliation: Division of Nephrology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38152, USA.
authors.forename: Miklos Z
authors.initials: MZ
authors.lastname: Molnar
authors.affiliation: Renal Transplant Program, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8.
authors.forename: G V Ramesh
authors.initials: GV
authors.lastname: Prasad
authors.affiliation: Renal Transplant Program, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8 ; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada M5B 1W8.
authors.forename: Darren A
authors.initials: DA
authors.lastname: Yuen
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5S 1A1.
authors.forename: Serge
authors.initials: S
authors.lastname: Jothy
authors.affiliation: Renal Transplant Program, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W8 ; Division of Nephrology, St. Michael's Hospital, 61 Queen Street East, Room No. 9-118, Toronto, ON, Canada M5C 2T2.
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Zaltzman