title: Enhanced DNA toehold exchange reaction on a chip surface to discriminate single-base changes.
abstract: In this study, a single-base change discrimination strategy was developed through enhanced DNA toehold exchange reaction on a chip surface. A DNA strand with single-base change (SNPs, insertion or deletion) at an arbitrary position was clearly discriminated with nucleic acid concentrations from 0.8 nM to 1 μM through this method.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China. fjhuang@ustc.edu.cn hjliang@ustc.edu.cn.
authors.forename: Huaguo
authors.initials: H
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Fujian
authors.initials: F
authors.lastname: Huang
authors.forename: Shiyan
authors.initials: S
authors.lastname: Xiao
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Haojun
authors.initials: H
authors.lastname: Liang
mesh_terms: D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000737:chemistry; D013499:Surface Properties
chemical_list: D015342:DNA Probes; D004247:DNA