title: Cough-related neural processing in the brain: a roadmap for cough dysfunction?
abstract: Cough is a complex respiratory behavior essential for airway protection, consisting of sensory, motor, affective and cognitive attributes. Accordingly, the cough neural circuitry extends beyond a simple pontomedullary reflex arc to incorporate a network of neurons that are also widely distributed throughout the subcortical and cortical brain. Studies have described discrete regional responses in the brain that likely give rise to sensory discriminative processes, voluntary and urge-related cough control mechanisms and aspects of the emotive responses following airways irritation and coughing. Data from these studies highlight the central nervous system as a plausible target for therapeutic intervention and, consistent with this, a careful appraisal of the many and varied clinical disorders of coughing control would argue that more diversified therapies are needed to treat patients with cough dysfunction. In this paper we explore these concepts in detail to highlight unanswered questions and stimulate discussion for potential research of cough in the future.
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia; School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. Electronic address: ayaka.ando@florey.edu.au.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Ando
authors.affiliation: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: michael.farrell@florey.edu.au.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Farrell
authors.affiliation: School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia.
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Mazzone
mesh_terms: D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003371:Cough / Q000503:physiopathology*; D006801:Humans; D009415:Nerve Net / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology; D012018:Reflex / Q000502:physiology*
keywords: Cough dysfunction; Cough hypersensitivity; Urge-to-cough; fMRI