title: Improved delivery of magnetic nanoparticles with chemotherapy cancer treatment.
abstract: Most nanoparticle-based cancer therapeutic strategies seek to develop an effective individual cancer cell or metastatic tumor treatment. Critical to the success of these therapies is to direct as much of the agent as possible to the targeted tissue while avoiding unacceptable normal tissue complications. In this light, three different cisplatinum/magnetic nanoparticle (mNP) administration regimens were investigated. The most important finding suggests that clinically relevant doses of cisplatinum result in a significant increase in the tumor uptake of systemically delivered mNP. This enhancement of mNP tumor uptake creates the potential for an even greater therapeutic ratio through the addition of mNP based, intracellular hyperthermia.
authors.affiliation: Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH USA 03755.
authors.forename: Alicia A
authors.initials: AA
authors.lastname: Petryk
authors.affiliation: Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH USA 03755 ; Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd., Hanover, NH USA 03755.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Giustini
authors.affiliation: Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd., Hanover, NH USA 03755.
authors.forename: Rachel E
authors.initials: RE
authors.lastname: Gottesman
authors.affiliation: Thayer School of Engineering, Dartmouth College, 14 Engineering Dr., Hanover, NH USA 03755 ; Geisel School of Medicine, Dartmouth College, 1 Rope Ferry Rd., Hanover, NH USA 03755.
authors.forename: P Jack
authors.initials: PJ
authors.lastname: Hoopes
keywords: CDDP; Cisplatinum; Hyperthermia; Magnetic nanoparticle