title: Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study.
abstract: OBJECTIVE
  The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.
  
  
  BACKGROUND
  It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET.
  
  
  METHODS
  Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.
  
  
  RESULTS
  The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.
  
  
  CONCLUSIONS
  SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.|IM Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, Russia.
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Nesterov
authors.affiliation: Lausanne University Hospital, Lausanne, Switzerland.|Regional Cancer Institute of Montpellier (ICM) - Val d'Aurelle, Montpellier, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Deshayes
authors.affiliation: University of Florence, Florence, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Sciagrà
authors.affiliation: University of Florence, Florence, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Settimo
authors.affiliation: Siemens Molecular Imaging, Oxford, United Kingdom.
authors.forename: Jerome M
authors.initials: JM
authors.lastname: Declerck
authors.affiliation: Siemens Molecular Imaging, Oxford, United Kingdom.
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Pan
authors.affiliation: Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Yoshinaga
authors.affiliation: Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Chietsugu
authors.initials: C
authors.lastname: Katoh
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, California, United States.
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Slomka
authors.affiliation: Cedars-Sinai Medical Center, Los Angeles, California, United States.
authors.forename: Guido
authors.initials: G
authors.lastname: Germano
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Chunlei
authors.initials: C
authors.lastname: Han
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Ville
authors.initials: V
authors.lastname: Aalto
authors.affiliation: University of Washington, Seattle, Washington, United States.
authors.forename: Adam M
authors.initials: AM
authors.lastname: Alessio
authors.affiliation: University of Michigan Health Systems, Ann Arbor, Michigan, United States.
authors.forename: Edward P
authors.initials: EP
authors.lastname: Ficaro
authors.affiliation: INVIA Medical Imaging Solutions, Ann Arbor, Michigan, United States.
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Lee
authors.affiliation: Department of Nuclear Medicine, Technical University, Munich, Germany.
authors.forename: Stephan G
authors.initials: SG
authors.lastname: Nekolla
authors.affiliation: Advanced Analytics LLC, Gaithersburg, Maryland, United States.
authors.forename: Kilem L
authors.initials: KL
authors.lastname: Gwet
authors.affiliation: National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, Canada.
authors.forename: Robert A
authors.initials: RA
authors.lastname: deKemp
authors.affiliation: National Cardiac PET Center, University of Ottawa Heart Institute, Ottawa, Canada.
authors.forename: Ran
authors.initials: R
authors.lastname: Klein
authors.affiliation: University College London, London, United Kingdom.
authors.forename: John
authors.initials: J
authors.lastname: Dickson
authors.affiliation: Cardiovascular Imaging Technologies, Kansas City, Missouri, United States.
authors.forename: James A
authors.initials: JA
authors.lastname: Case
authors.affiliation: Cardiovascular Imaging Technologies, Kansas City, Missouri, United States.
authors.forename: Timothy
authors.initials: T
authors.lastname: Bateman
authors.affiliation: Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: John O
authors.initials: JO
authors.lastname: Prior
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Juhani M
authors.initials: JM
authors.lastname: Knuuti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005060:Europe; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007564:Japan; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D015588:Observer Variation; D009864:Ontario; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012414:Rubidium Radioisotopes / Q000493:pharmacokinetics; D012984:Software; D014481:United States
chemical_list: D019275:Radiopharmaceuticals; D012414:Rubidium Radioisotopes
keywords: CAD; PET; imaging software; reproducibility; rubidium-82