title: Does β-APP staining of the brain in infant bed-sharing deaths differentiate these cases from sudden infant death syndrome?
abstract: Archival cerebral tissue from infants whose deaths were attributed to sudden infant death syndrome (SIDS) from South Australia and Western Denmark were stained for β-amyloid precursor protein (β-APP) and graded according to a simple scoring chart. The resulting APP scores were correlated with sleeping situation (shared vs. alone) showing a significantly higher amount of β-APP staining in the non-bed-sharing, than in the bed-sharing infants (Mann-Whitney, Australia: p = 0.0128, Denmark: p = 0.0014, Combined: p = 0.0031). There was also a marked but non-significant difference in sex distribution between bed-sharers and non-bed-sharers with a male to female ratio of 1:1 in the first group and 2:1 in the latter. Of 48 Australian and 76 Danish SIDS infants, β-APP staining was present in 116 (94%) cases. The eight negative cases were all from the Danish cohort. This study has shown that the amount of β-APP staining was significantly higher in infants who were sleeping alone compared to those who were bed-sharing with one or more adults, in both an Australian and Danish cohort of SIDS infants. Whether this results from differences in the speed with which these infants die, differences in lethal mechanisms involving possible accidental asphyxiation in shared sleepers, or differences in the number of previous hypoxic-ischemic events, remains to be clarified.
authors.affiliation: Discipline of Anatomy and Pathology, The University of Adelaide, Frome Road, SA 5005, Australia; Department of Forensic Medicine, Aarhus University, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark; The Department of Pathology, Aarhus University Hospital, Nørrebrogade, 8000 Aarhus C, Denmark. Electronic address: lislunjn@rm.dk.
authors.forename: Lisbeth Lund
authors.initials: LL
authors.lastname: Jensen
authors.affiliation: Department of Forensic Medicine, Aarhus University, Brendstrupgaardsvej 100, 8200 Aarhus N, Denmark; Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, 2100 Copenhagen East, Denmark.
authors.forename: Jytte
authors.initials: J
authors.lastname: Banner
authors.affiliation: Discipline of Anatomy and Pathology, The University of Adelaide, Frome Road, SA 5005, Australia.
authors.forename: Roger W
authors.initials: RW
authors.lastname: Byard
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001315:Australia; D001513:Beds; D001921:Brain / Q000378:metabolism*; D003718:Denmark; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007223:Infant; D008297:Male; D017678:Sex Distribution; D012890:Sleep; D013194:Staining and Labeling; D013398:Sudden Infant Death
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: Asphyxia; Bed sharing; Cosleeping; Hypoxic-ischemia; SIDS; β-APP