title: Evaluation of bioactive properties and phenolic compounds in different extracts prepared from Salvia officinalis L.
abstract: The therapeutic benefits of medicinal plants are well known. Nevertheless, essential oils have been the main focus of antioxidant and antimicrobial studies, remaining scarce the reports with hydrophilic extracts. Thus, the antioxidant and antifungal activities of aqueous (prepared by infusion and decoction) and methanol/water (80:20, v/v) extracts of sage (Salvia officinalis L.) were evaluated and characterised in terms of phenolic compounds. Decoction and methanol/water extract gave the most pronounced antioxidant and antifungal properties, being positively related with their phenolic composition. The highest concentration of phenolic compounds was observed in the decoction, followed by methanol/water extract and infusion. Fungicidal and/or fungi static effects proved to be dependent on the extracts concentration. Overall, the incorporation of sage decoction in the daily diet or its use as a complement for antifungal therapies, could provide considerable benefits, also being an alternative to sage essential oils that can display some toxic effects.
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal; CEB, Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
authors.forename: Natália
authors.initials: N
authors.lastname: Martins
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
authors.forename: Lillian
authors.initials: L
authors.lastname: Barros
authors.affiliation: GIP-USAL, Faculty of Pharmacy, University of Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain.
authors.forename: Celestino
authors.initials: C
authors.lastname: Santos-Buelga
authors.affiliation: CEB, Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
authors.forename: Mariana
authors.initials: M
authors.lastname: Henriques
authors.affiliation: CEB, Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal.
authors.forename: Sónia
authors.initials: S
authors.lastname: Silva
authors.affiliation: Mountain Research Centre (CIMO), ESA, Polytechnic Institute of Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal. Electronic address: iferreira@ipb.pt.
authors.forename: Isabel C F R
authors.initials: IC
authors.lastname: Ferreira
mesh_terms: D000935:Antifungal Agents; D000975:Antioxidants / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D027543:Salvia officinalis / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000975:Antioxidants; D010636:Phenols
keywords: Antifungal activity; Antioxidant activity; Hydrophilic extracts; Salvia officinalis L.