title: The first steps towards the era of personalised vaccinology: predicting adverse reactions.
abstract: Until now, the occurrence of adverse reactions among individuals inoculated with identical vaccines has been ascribed to unpredictable stochastic processes. Recent advances in pharmacogenomics indicate that some features of host response to immunisation are influenced by genetic traits, henceforth predictable. The ability to predict the adverse reaction to vaccination would represent an important step towards the development of personalised vaccinology and could enhance public confidence in the safety of vaccines. Herein, we have reviewed all the available information on the association between genetic variants and the risk for healthy subjects to develop adverse reactions.
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Pellegrino
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: F S
authors.initials: FS
authors.lastname: Falvella
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Perrone
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Carnovale
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Brusadelli
authors.affiliation: Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pozzi
authors.affiliation: IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Antoniazzi
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cheli
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Perrotta
authors.affiliation: 1] Scientific Institute, IRCCS E. Medea, Bosisio Parini, Lecco, Italy [2] Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Clementi
authors.affiliation: Unit of Clinical Pharmacology, Department of Biomedical and Clinical Sciences, University Hospital 'Luigi Sacco', Universitá di Milano, Milan, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Radice
mesh_terms: D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics / Q000379:methods; D012306:Risk; D014611:Vaccination / Q000009:adverse effects*; D014612:Vaccines / Q000009:adverse effects*
chemical_list: D014612:Vaccines