title: Tolerance in T-cell clones.
abstract: The interaction of antigen with immunologically competent cells may lead either to the induction of an immune response or to a state of antigen specific unresponsiveness complete orpartial, which is often called immunological 'tolerance'. This is believed to be a major mechanism of discrimination between self and non-self(1-3). In this review Marc Feldmann and his colleagues discuss new insights into T-cell tolerance in vivo and in vitro, and discuss their significance for our understanding of mechanisms of immune activation and regulation.
authors.affiliation: ICRF Tumour Immunology Unit, Zoology Department, University College London, London WC 1E 6BT, UK.
authors.forename: M
authors.initials: M
authors.lastname: Feldmann
authors.affiliation: Department of Immunobiology, Glaxo Group Research, Greenford, Middlesex, UK.
authors.forename: E D
authors.initials: ED
authors.lastname: Zanders
authors.affiliation: MRC Tuberculosis and Related Infections Unit, Hammersmith Hospital, London W12 OHS, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Lamb