title: The role of integrin antagonists in the treatment of inflammatory bowel disease.
abstract: BACKGROUND
  Ulcerative colitis (UC) and Crohn's disease are chronic inflammatory diseases of the bowel associated with complex inflammatory cascades within the mucosal lining of the gut.
  
  
  METHODS
  INTEGRINS and their use as therapies in UC and Crohn's.
  
  
  CONCLUSIONS
  The anti-adhesion molecules are a welcome addition to the armamentarium of medical therapies for inflammatory bowel disease.
authors.affiliation: University of Wisconsin School of Medicine and Public Health , 1685 Highland Avenue Madison, WI 53705 , USA.
authors.forename: Poonam
authors.initials: P
authors.lastname: Beniwal-Patel
authors.forename: Sumona
authors.initials: S
authors.lastname: Saha
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000276:immunology; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003424:Crohn Disease / Q000188:drug therapy; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy*; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000276:immunology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D015815:Cell Adhesion Molecules; D005765:Gastrointestinal Agents; D016023:Integrins; C543529:vedolizumab
keywords: Crohn’s disease; immunomodulator; inflammation; integrin; natalizumab; ulcerative colitis; vedolizumab