title: Nosocomial infections by Klebsiella pneumoniae carbapenemase producing enterobacteria in a teaching hospital.
abstract: OBJECTIVE
  To analyze the profile of patients with microorganisms resistant to carbapenems, and the prevalence of the enzyme Klebsiella pneumoniae carbapenemase in interobacteriaceae.
  
  
  METHODS
  Retrospective descriptive study. From the isolation in bacteriological tests ordered by clinicians, we described the clinical and epidemiological characteristics of patients with enterobacteria resistants to carbapenems at a university hospital, between March and October 2013.
  
  
  RESULTS
  We included 47 isolated patients in this study, all exhibiting resistance to carbapenems, including 9 patients who were confirmed as infected/colonized with K. pneumoniae carbapenemase. Isolation in tracheal aspirates (12; 25.5%) predominated. The resistance to ertapenem, meropenem, and imipenem was 91.5%, 83.0% and 80.0%, respectively. Aminoglycosides was the class of antimicrobials that showed the highest sensitivity, 91.5% being sensitive to amikacin and 57.4% to gentamicin.
  
  
  CONCLUSIONS
  The K. pneumoniae carbapenemase was an important agent in graun isotaling in hospital intection. The limited therapeutic options emphasize the need for rapid laboratory detection, as well as the implementation of measures to prevent and control the spread of these pathogens.
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Seibert
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Rosmari
authors.initials: R
authors.lastname: Hörner
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Bettina Holzschuh
authors.initials: BH
authors.lastname: Meneghetti
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Roselene Alves
authors.initials: RA
authors.lastname: Righi
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Nara Lucia Frasson
authors.initials: NL
authors.lastname: Dal Forno
authors.affiliation: Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Adenilde
authors.initials: A
authors.lastname: Salla
mesh_terms: D000293:Adolescent; D000328:Adult; D001426:Bacterial Proteins / Q000096:biosynthesis*; D015780:Carbapenems / Q000627:therapeutic use; D002648:Child; D003428:Cross Infection / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000201:enzymology / Q000382:microbiology; D005260:Female; D006784:Hospitals, Teaching / Q000706:statistics & numerical data; D006801:Humans; D007710:Klebsiella Infections / Q000201:enzymology* / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification; D008297:Male; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies; D055815:Young Adult; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase