title: Aptamer-conjugated theranostic hybrid graphene oxide with highly selective biosensing and combined therapy capability.
abstract: Cancer is a life-threatening disease, which is rapidly becoming a global pandemic. Driven by this need, here we report for the first time an aptamer-conjugated theranostic magnetic hybrid graphene oxide-based assay for highly sensitive tumor cell detection from blood samples with combined therapy capability. AGE-aptamer-conjugated theranostic magnetic nanoparticle-attached hybrid graphene oxide was developed for highly selective detection of tumor cells from infected blood samples. Experimental data indicate that hybrid graphene can be used as a multicolor luminescence platform for selective imaging of G361 human malignant melanoma cancer cells. The reported results have also shown that indocyanine green (ICG)-bound AGE-aptamer-attached hybrid graphene oxide is capable of combined synergistic photothermal and photodynamic treatment of cancer. Targeted combined therapeutic treatment using 785 nm near-infrared (NIR) light indicates that the multimodal therapeutic treatment is highly effective for malignant melanoma cancer therapy. The reported data show that this aptamer-conjugated theranostic graphene oxide-based assay has exciting potential for improving cancer diagnosis and treatment.
authors.affiliation: Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA. paresh.c.ray@jsums.edu.
authors.forename: Bhanu Priya
authors.initials: BP
authors.lastname: Viraka Nellore
authors.forename: Avijit
authors.initials: A
authors.lastname: Pramanik
authors.forename: Suhash Reddy
authors.initials: SR
authors.lastname: Chavva
authors.forename: Sudarson Sekhar
authors.initials: SS
authors.lastname: Sinha
authors.forename: Christen
authors.initials: C
authors.lastname: Robinson
authors.forename: Zhen
authors.initials: Z
authors.lastname: Fan
authors.forename: Rajashekhar
authors.initials: R
authors.lastname: Kanchanapally
authors.forename: Justin
authors.initials: J
authors.lastname: Grennell
authors.forename: Ivy
authors.initials: I
authors.lastname: Weaver
authors.forename: Ashton T
authors.initials: AT
authors.lastname: Hamme
authors.forename: Paresh Chandra
authors.initials: PC
authors.lastname: Ray
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry; D015374:Biosensing Techniques / Q000379:methods*; D045744:Cell Line, Tumor; D006108:Graphite / Q000737:chemistry; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry; D015394:Molecular Structure; D009369:Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D010087:Oxides / Q000737:chemistry; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D013499:Surface Properties
chemical_list: D052157:Aptamers, Nucleotide; D010087:Oxides; D017319:Photosensitizing Agents; D006108:Graphite; D007208:Indocyanine Green