title: Confocal Laser Scanning Tomography to Predict Visual Field Conversion in Patients With Ocular Hypertension and Early Glaucoma.
abstract: To compare Moorfields regression analysis (MRA), Glaucoma probability score (GPS), and different discriminant functions to predict future visual field conversion of patients with ocular hypertension and early glaucoma.
  
  
  
  The study included 120 eyes of patients with ocular hypertension and 110 eyes of patients with early glaucoma from the Erlangen glaucoma registry. Annually, all patients underwent standard automated perimetry, 24-hour intraocular pressure profile, optic disc photography, and HRT (Heidelberg Retina Tomograph I-III; Heidelberg Engineering) measurements. The cohort was divided into 2 groups based on the development of repeatable glaucomatous visual fields. Positive predictive values and negative predictive values were compared for MRA, GPS, and the classification of Bathija, Iester, Mardin, and Mikelberg at baseline. Kaplan-Meier Survival curves and Logrank tests were used to evaluate equality of survival distributions for different test results.
  
  
  
  Median follow-up was 9.04 years. 26 eyes (11.3%) demonstrated glaucomatous visual field loss in the follow-up. MRA temporal-superior and temporal-inferior outside normal limits were predictive of future visual field loss with positive predictive values of 33.3% and 28.6%. Normal GPS Temporal Sector demonstrated a negative predictive value of 96.4% and normal results in discriminant functions between 94.7% and 95.5%.
  
  
  
  Confocal scanning laser tomography is a useful imaging modality to predict future visual field conversion. Development of visual field defects in 10 years is highly unlikely, if GPS classification and/or classification of discriminant analysis at baseline are normal. MRA temporal-superior and temporal-inferior outside normal limits are associated with future VF conversion (ClinicalTrials.gov number, NCT00494923).
authors.affiliation: Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage, Erlangen, Germany.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Schrems-Hoesl
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Schrems
authors.forename: Robert
authors.initials: R
authors.lastname: Laemmer
authors.forename: Folkert K
authors.initials: FK
authors.lastname: Horn
authors.forename: Anselm G M
authors.initials: AG
authors.lastname: Juenemann
authors.forename: Friedrich E
authors.initials: FE
authors.lastname: Kruse
authors.forename: Christian Y
authors.initials: CY
authors.lastname: Mardin
mesh_terms: D000328:Adult; D042241:Early Diagnosis; D005189:False Positive Reactions; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011336:Probability; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014054:Tomography; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000175:diagnosis*; D014794:Visual Fields