title: Structure of diarylheptanoids with antiallergic activity from the rhizomes of Curcuma comosa.
abstract: The methanolic extract from the dried rhizomes of Curcuma comosa cultivated in Thailand was found to inhibit the release of β-hexosaminidase as a maker of degranulation from rat basophil leukemia (RBL-2H3) cells. Two new diarylheptanoids, diarylcomosols IV and V, were isolated from the methanolic extract. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The isolated diarylheptanoids showed inhibitory activity, and the structural requirements of the active constituents for the inhibition were clarified.
authors.affiliation: Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Fujimoto
authors.forename: Tomoe
authors.initials: T
authors.lastname: Ohta
authors.forename: Keiko
authors.initials: K
authors.lastname: Ogawa
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Eri
authors.initials: E
authors.lastname: Onishi
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukaya
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D030024:Curcuma / Q000737:chemistry*; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D027343:Rhizome / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D036381:Diarylheptanoids; D010936:Plant Extracts