title: Far from the eyes, close to the heart: dysbiosis of gut microbiota and cardiovascular consequences.
abstract: These days, the gut microbiota is universally recognized as an active organ that can modulate the overall host metabolism by promoting multiple functions, from digestion to the systemic maintenance of overall host physiology. Dysbiosis, the alteration of the complex ecologic system of gut microbes, is associated with and causally responsible for multiple types of pathologies. Among the latters, metabolic diseases such as type 2 diabetes and obesity are each distinguishable by a unique gut microbiota profile. Interestingly, the specific microbiota typically found in the blood of diabetic patients also has been observed at the level of atherosclerotic plaque. Here, we report evidence from the literature, as well as a few controversial reports, regarding the putative role of gut microbiota dysbiosis-induced cardiovascular diseases, such as atherosclerosis, which are common comorbidities of metabolic dysfunction.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France, matteo.serino@inserm.fr.
authors.forename: Matteo
authors.initials: M
authors.lastname: Serino
authors.forename: Vincent
authors.initials: V
authors.lastname: Blasco-Baque
authors.forename: Simon
authors.initials: S
authors.lastname: Nicolas
authors.forename: Remy
authors.initials: R
authors.lastname: Burcelin
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000209:etiology* / Q000276:immunology; D004195:Disease Models, Animal; D064806:Dysbiosis / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D019317:Evidence-Based Medicine; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology* / Q000382:microbiology*; D051379:Mice; D064307:Microbiota / Q000276:immunology*; D010518:Periodontitis / Q000150:complications* / Q000276:immunology; D019936:Probiotics / Q000627:therapeutic use; D051381:Rats