title: Role of Wnt signaling in fracture healing.
abstract: The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Huiyun
authors.initials: H
authors.lastname: Xu
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Duan
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Dandan
authors.initials: D
authors.lastname: Ning
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Jingbao
authors.initials: J
authors.lastname: Li
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Ruofei
authors.initials: R
authors.lastname: Liu
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Ruixin
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Biochemistry, University of Texas Health Science Center at San Antonio, Texas 78229, the United States.
authors.forename: Jean X
authors.initials: JX
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Shang
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D017102:Fracture Healing; D050723:Fractures, Bone / Q000378:metabolism / Q000473:pathology; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000378:metabolism; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway; D051176:beta Catenin / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D026502:LDL-Receptor Related Proteins; D051153:Wnt Proteins; D051176:beta Catenin; D038362:Glycogen Synthase Kinase 3