title: Concomitant development of hypersexuality and delusional jealousy in patients with Parkinson's disease: a case series.
abstract: BACKGROUND
  Both impulse-control disorders and delusional jealousy (DJ) may be considered non-motor side-effects of dopamine agonist therapy in Parkinson's disease (PD). We aimed to investigate the possible concomitant development of these features in PD and their clinical correlates.
  
  
  METHODS
  We performed a cross-sectional investigation in 1063 consecutive PD patients with the Questionnaire for Impulsive Compulsive Disorders in Parkinson's disease and the Parkinson's Psychosis Questionnaire.
  
  
  RESULTS
  81 patients presented ICDs (prevalence 7.61%) and 23 patients presented DJ (17 males, 6 females; prevalence 2.16%). 9 male PD patients presented both DJ and ICDs (39.13% of patients with DJ, 11.11% of patients with ICDs; prevalence of 0.84% in the whole PD sample), with a concomitant onset of delusional jealousy and hypersexuality in 8 cases and a concomitant onset of delusional jealousy and pathological gambling in 2 cases.
  
  
  CONCLUSIONS
  Hypersexuality and delusional jealousy may occur independently in PD patients "on" dopamine agonist therapy, but may develop together probably reflecting a common alteration of sexuality (sexual arousal and jealousy) The presence of both of these clinical features and sexuality more in general should be investigated when features of either one of them appear. Further confirmation is needed in larger samples of patients.
authors.affiliation: Department of Mental Health and Pathological Addiction, AUSL of Reggio Emilia, Reggio Emilia, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Poletti
authors.affiliation: Neurology Unit, Versilia Hospital, USL of Viareggio, Viareggio, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Lucetti
authors.affiliation: Department of Clinical and Experimental Medicine Neurology Unit, University of Pisa, Pisa, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Baldacci
authors.affiliation: Neurology Unit, Versilia Hospital, USL of Viareggio, Viareggio, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Dotto
authors.affiliation: Department of Clinical and Experimental Medicine Neurology Unit, University of Pisa, Pisa, Italy. Electronic address: u.bonuccelli@med.unipi.it.
authors.forename: Ubaldo
authors.initials: U
authors.lastname: Bonuccelli
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003702:Delusions / Q000453:epidemiology*; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000453:epidemiology*; D018491:Dopamine Agonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007578:Jealousy; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D015995:Prevalence; D019529:Sexuality / Q000502:physiology*
chemical_list: D018491:Dopamine Agonists
keywords: Delusional jealousy; Hypersexuality; Impulse control disorders; Parkinson's disease