title: Angiographic evidence of peripheral ischemia in diabetic retinopathy and the risk of impending neovascularisation.
abstract: The appearance of biomicroscopic evidence of neovascularisation is the main indication for scatter laser treatment in patients with known diabetic eye disease. We describe a patient with an unusually aggressive variant of proliferative disease and a distinct angiographic signature. In an interventional case report with angiographic findings, we found that angiographic evidence of extensive capillary dropout in patients with known diabetic retinopathy should translate into a low threshold for panretinal photocoagulation treatment based on a high risk for progression to sight-threatening proliferative disease. Angiography may be a useful adjunct in stratifying patients with diabetic eye disease according to risk. Those with extensive ischemia, even without neovascularisation, should be considered for early panretinal photocoagulation.
authors.affiliation: Department of Ophthalmology, St James's University Hospitals, Leeds, United Kingdom.
authors.forename: David S M
authors.initials: DS
authors.lastname: Burton
authors.affiliation: Department of Ophthalmology, St James's University Hospitals, Leeds, United Kingdom. Electronic address: zia.carrim@doctors.org.uk.
authors.forename: Zia I
authors.initials: ZI
authors.lastname: Carrim
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000627:therapeutic use; D000068258:Bevacizumab; D003930:Diabetic Retinopathy / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D005451:Fluorescein Angiography; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007511:Ischemia / Q000150:complications / Q000175:diagnosis*; D008028:Light Coagulation; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D011859:Radiography; D018570:Risk Assessment
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab
keywords: diabetic macular oedema; glaucome néovasculaire; neovascular glaucoma; proliferative diabetic retinopathy; rétinopathie diabétique proliférante; œdème maculaire diabétique