title: Is there a role for the MTHFR 677C>T and 1298A>C polymorphisms in methotrexate-induced liver toxicity?
authors.affiliation: Department of Pediatric Hematology & Oncology, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
authors.forename: D Maroeska W M
authors.initials: DM
authors.lastname: te Loo
authors.forename: Melanie M
authors.initials: MM
authors.lastname: Hagleitner
authors.forename: Marieke J H
authors.initials: MJ
authors.lastname: Coenen
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000235:genetics*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008727:Methotrexate / Q000009:adverse effects*; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D008727:Methotrexate
keywords: MTX toxicity; meta-analysis; pharmacogenetics; pharmacogenomics; replication study