title: Subtle bilirubin-induced neurodevelopmental dysfunction (BIND) in the term and late preterm infant: does it exist?
abstract: Subtle bilirubin-induced neurological dysfunction (BIND) is defined as disturbances in sensory and sensorimotor integration, central auditory processing, coordination, and muscle tone in the absence of the classical findings of kernicterus. This review is restricted to the (sensori)motor signs of BIND associated with unconjugated hyperbilirubinemia in term and late preterm neonates. The diagnosis of BIND at follow-up requires validated, age-specific techniques that are designed to identify these disturbances in infancy and later childhood. The (sensori)motor signs of BIND are compatible with the pathological substrate of unconjugated hyperbilirubinemia and its known effects on the brain.
authors.affiliation: Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands. Electronic address: r.j.lunsing@umcg.nl.
authors.forename: Roelineke J
authors.initials: RJ
authors.lastname: Lunsing
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases; D007647:Kernicterus / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D009420:Nervous System / Q000254:growth & development; D009422:Nervous System Diseases / Q000209:etiology; D066191:Sensorimotor Cortex