title: Marchiafava-Bignami disease with hyperintensity on late diffusion-weighted imaging.
abstract: A 69-year-old man with a decades-long history of chronic alcohol consumption was admitted with gait disturbance (short steps and spasticity), deterioration of activity, and stuporous consciousness. Head magnetic resonance imaging (MRI) revealed hyperintensity on fluid-attenuated inversion recovery imaging in the corpus callosum and frontal white matter. The lesion later became more apparent on diffusion-weighted imaging. The clinical diagnosis was Marchiafava-Bignami disease (MBD). As temporary treatment, refraining from alcohol consumption and administration of vitamins were prescribed. The condition of the patient gradually improved. The purposes of this study were to demonstrate the clinical and radiological variety of MBD and to identify practical methods of treatment of this pathology.
authors.affiliation: Division of Radiology, Ohmihachiman Community Medical Center, Shiga, Japan.
authors.forename: Takayasu
authors.initials: T
authors.lastname: Iwai
authors.affiliation: Division of Neurology, Ohmihachiman Community Medical Center, Shiga, Japan.
authors.forename: Koushun
authors.initials: K
authors.lastname: Matsuo
authors.affiliation: Division of Neurology, Ohmihachiman Community Medical Center, Shiga, Japan ; Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Fukiko
authors.initials: F
authors.lastname: Morii-Kitani
authors.affiliation: Division of Radiology, Ohmihachiman Community Medical Center, Shiga, Japan.
authors.forename: Fumiko
authors.initials: F
authors.lastname: Azuma
authors.affiliation: Division of Radiology, Ohmihachiman Community Medical Center, Shiga, Japan.
authors.forename: Hisayasu
authors.initials: H
authors.lastname: Matsuo
authors.affiliation: Division of Radiology, Ohmihachiman Community Medical Center, Shiga, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takada
authors.affiliation: Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan ; Department of Neurology, North Medical Center, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Nakagawa
authors.affiliation: Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Mizuno
authors.affiliation: Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Yamada
keywords: Marchiafava-Bignami disease (MBD); late diffusion-weighted imaging; white-matter lesions