title: Can a death signal half-life be used to sense the distance to a lesion site in axons?
abstract: Neuron response to injury depends on the distance to the lesion site, which means that neurons are capable of sensing this distance. Several mechanisms explaining how neurons can do this have been proposed and it is possible that neurons use a combination of several mechanisms to make such measurements. In this paper we investigate the feasibility of the simplest mechanism, which is based on the hypothesis that death signals, produced at the lesion site, propagate toward the neuron soma. The signals are propelled by dynein motors. If signals have a finite half-life, they decay as they propagate. By measuring the concentration of death signals arriving to the soma, neurons should thus be able to determine the distance to the injury site. We develop and solve a transport equation based on the above model. We investigate how a death signal distribution depends on the dynein velocity distribution. We evaluate the efficiency of such a mechanism by investigating the sensitivity of death signal concentration at the soma to the distance to the injury site. By using the hypothesis that system performance is optimized by evolution, we evaluate death signal half-lives that would maximize this sensitivity.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21218-2694, USA, ikuznet1@jhu.edu.
authors.forename: I A
authors.initials: IA
authors.lastname: Kuznetsov
authors.forename: A V
authors.initials: AV
authors.lastname: Kuznetsov
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D016923:Cell Death; D004398:Dyneins / Q000378:metabolism; D005240:Feasibility Studies; D006207:Half-Life; D008959:Models, Neurological; D015398:Signal Transduction
chemical_list: D000255:Adenosine Triphosphate; D004398:Dyneins