title: The accuracy of C-reactive protein, procalcitonin, and s-TREM-1 in the prediction of serious bacterial infection in neonates.
abstract: In this prospective study, we examined the usefulness of C-reactive protein (CRP), soluble triggering receptor expressed on myeloid cells (s-TREM-1), and procalcitonin (PCT), in identifying serious bacterial infection (SBI) among neonates. Infants younger than 3 months with suspected SBI were included and serum concentrations of CRP, PCT, and s-TREM-1 were determined.
  
  
  RESULTS
  A total of 112 patients (19 with SBI and 93 with negative cultures) were evaluated. There were no statistical differences between the 2 groups regarding age, presence of fever, and serum concentrations of the different biomarkers. Performance of the different biomarkers were as follows: The sensitivities were 45%, 55%, and 82% for CRP, PCT, and s-TREM-1, respectively, whereas the specificities we 82%, 75%, and 48% for CRP, PCT, and s-TREM-1, respectively. The areas under the receiver operating characteristic curve were 0.6, 0.63, and 0.61, for CRP, PCT, and s-TREM-1, respectively.
  
  
  CONCLUSIONS
  In real-life pediatric practice, none of the tested biomarkers was sufficiently accurate to serve as a reliable indicator for the identification of SBI in neonates.
authors.affiliation: Wolfson Medical Center, Holon, Israel The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Michal
authors.initials: M
authors.lastname: Stein
authors.affiliation: Tel Aviv Medical Center, Tel Aviv, Israel.
authors.forename: Anita
authors.initials: A
authors.lastname: Schachter-Davidov
authors.affiliation: Rabin Medical Center, Petach Tikva, Israel.
authors.forename: Ilan
authors.initials: I
authors.lastname: Babai
authors.affiliation: Wolfson Medical Center, Holon, Israel The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Diana
authors.initials: D
authors.lastname: Tasher
authors.affiliation: Wolfson Medical Center, Holon, Israel The Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel esomekh@gmail.com.
authors.forename: Eli
authors.initials: E
authors.lastname: Somekh
mesh_terms: D001424:Bacterial Infections / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007557:Israel; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D011446:Prospective Studies; D011498:Protein Precursors / Q000097:blood*; D012372:ROC Curve; D011971:Receptors, Immunologic / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide
keywords: C-reactivel protein; neonate; procalcitonin; s-TREM-1; sepsis