title: In vitro pharmacological screening of three newly synthesised pyrimidine derivatives.
abstract: The antibacterial and antifungal activities of three new pyrimidine derivatives, namely, 2,6-bis(4,6-dimethylpyrimidin-2-ylthio)benzene-1,4-diol (1),3,5-bis(4,6-dimethylpyrimidin-2-ylthio)-2-methylbenzene-1,4-diol (2) and 3,5-bis(4,6-dimethylpyrimidin-2-ylthio)-2-methoxybenzene-1,4-diol (3), synthesised by electrochemical method are presented here. The compounds were screened for their activities against Gram-positive and Gram-negative bacteria, Bacillus subtilis, Staphylococcusaureus, Escherichia coli and a pathogenic fungus Aspergillus niger. The results show that these compounds have significant activity against these bacteria and fungus. The minimum inhibitory concentration of compound 1 was determined as 62.5 μg/mL against B. subtilis, 125 μg/mL against E. coli and 250 μg/mL against S. aureus establishing its promising activities higher than susceptible ranges.
authors.affiliation: a School of Science, Beijing University of Chemical Technology , Beijing 100029 , P.R. China.
authors.forename: Zia Ul Haq
authors.initials: ZU
authors.lastname: Khan
authors.forename: Arif Ullah
authors.initials: AU
authors.lastname: Khan
authors.forename: Pingyu
authors.initials: P
authors.lastname: Wan
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Chen
authors.forename: Dandan
authors.initials: D
authors.lastname: Kong
authors.forename: Shafiullah
authors.initials: S
authors.lastname: Khan
authors.forename: Kamran
authors.initials: K
authors.lastname: Tahir
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011743:Pyrimidines
keywords: anti-bacterial activity; anti-fungal activity; pyrimidine derivatives