title: Contact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006-2011.
abstract: BACKGROUND
  Ingredients of leave-on cosmetics and body care products may sensitize. However, not every case of cosmetic intolerance is due to contact sensitization.
  
  
  OBJECTIVE
  To describe the frequency of contact sensitization due to cosmetics in a large clinic population, and a possible particular allergen pattern.
  
  
  METHODS
  Retrospective analysis of data from the Information Network of Departments of Dermatology, 2006-2011.
  
  
  RESULTS
  Of 69 487 patients tested, 'cosmetics, creams, sunscreens' was the only suspected allergen source category in 10 124 patients (14.6%). A final diagnosis 'allergic contact dermatitis' was stated in 2658 of these patients (26.3%).Compared to a control group, there were significantly more reactions to fragrance mixes I and II, balsam of Peru, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and lanolin alcohols. No special pattern of fragrance sensitization could be identified. Among the preservatives, MI was by far the leading allergen, while sensitization to other widely used compounds like parabens or phenoxyethanol was rare.
  
  
  CONCLUSIONS
  True allergic reactions to cosmetic ingredients are rarer than generally assumed. Limitation of exposure to MI in leave-on cosmetics and body care products is urgently needed.
authors.affiliation: Department of Dermatology, Venereology and Allergy, Charité Universitätsmedizin, Berlin, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Dinkloh
authors.affiliation: Department of Dermatology, Venereology and Allergy, Charité Universitätsmedizin, Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Worm
authors.affiliation: Information Network of Departments of Dermatology, Georg-August University, Göttingen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Geier
authors.affiliation: Information Network of Departments of Dermatology, Georg-August University, Göttingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Schnuch
authors.affiliation: Department of Dermatology, Venereology and Allergy, Ludwig-Maximilians-Universität, Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Wollenberg
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001453:Balsams / Q000009:adverse effects; D002019:Bufexamac / Q000009:adverse effects; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects; D012189:Retrospective Studies; D063465:Skin Cream / Q000009:adverse effects; D013473:Sunscreening Agents / Q000009:adverse effects; D013844:Thiazoles / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001453:Balsams; D003358:Cosmetics; D010476:Perfume; D011310:Preservatives, Pharmaceutical; D013473:Sunscreening Agents; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; D002019:Bufexamac; C025080:Peruvian balsam; C011421:5-chloro-2-methyl-4-isothiazolin-3-one