title: Elevation of biomarkers and long-term outcome after percutaneous coronary intervention.
abstract: OBJECTIVE
  The impact of an elevation of cardiac biomarkers occurring after percutaneous coronary intervention (PCI) on long-term outcome remains controversial. Most available data are based on observational registries using multivariable analysis. In this study, a case-control approach was used to assess separately the impact of post-PCI elevation of CK-MB on the short-term in-hospital outcome and on the long-term outcome after hospital discharge.
  
  
  METHODS
  Between 1 January 1996 and 31 December 2008, a postprocedural rise of CK-MB was observed in 363 among 8346 consecutive PCI procedures (4·3%). The overall in-hospital mortality for patients with or without CK-MB elevation after PCI was 8·5% and 1·5%, respectively (P < 0·001). For 245 hospital survivors with CK-MB elevation, we found 245 control cases matched for 9 relevant clinical parameters in our PCI database during the same period. The long-term survival of these patients was assessed by KM estimates.
  
  
  RESULTS
  Despite an increased in-hospital mortality among patients with periprocedural elevation of CK-MB, the long-term outcome of patients who are discharged alive is independent of CK-MB release, curves of overall survival and of survival free of recurrence of myocardial infarction being similar up to 10 years after hospital discharge.
  
  
  CONCLUSIONS
  In our population, the elevation of CK-MB after PCI identified a high-risk subgroup for in-hospital mortality but had no impact on the long-term prognosis, once the patient is discharged alive from the hospital.
authors.affiliation: Division of Cardiology, CHU Dinant Godinne, UCL Namur, Belgium.
authors.forename: Alisson
authors.initials: A
authors.lastname: Slimani
authors.forename: Claude
authors.initials: C
authors.lastname: Hanet
authors.forename: Jacques
authors.initials: J
authors.lastname: Jamart
authors.forename: Laurence
authors.initials: L
authors.lastname: Gabriel
authors.forename: Antoine
authors.initials: A
authors.lastname: Guedes
authors.forename: Vincent
authors.initials: V
authors.lastname: Dangoisse
authors.forename: Laurence M
authors.initials: LM
authors.lastname: Galanti
authors.forename: Erwin
authors.initials: E
authors.lastname: Schroeder
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D052279:Creatine Kinase, MB Form / Q000378:metabolism*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D053208:Kaplan-Meier Estimate; D008134:Long-Term Care; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000401:mortality*; D011182:Postoperative Care; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D052279:Creatine Kinase, MB Form
keywords: Biomarkers; coronary intervention