title: Novel hydroxyapatite biomaterial covalently linked to raloxifene.
abstract: Since raloxifene, a drug used in osteoporosis therapy, inhibits osteoclast, but not osteoblast functions, it has been suggested to improve recovery during implant surgery. The present paper describes an effective method to link raloxifene, through a covalent bond, to a nano-Hydroxyapatite-based biomaterial by interfacing with (3-aminopropyl)-Triethoxysilane as assessed by Infra Red-Fourier Transformed (IR-FT) spectroscopy and Scanning Electron Microscope (SEM). To evaluate the safety of this modified new material, the vitality of osteoblast-like cells cultured with the new biomaterial was then investigated. Raloxifene-conjugated HAbiomaterial has been shown to be a safe material easy to obtain which could be an interesting starting point for the use of a new functional biomaterial suitable in bone regeneration procedures.
authors.affiliation: Department of Clinical Specialistic and Stomatological Sciences, Marche Polytechnic University, Ancona, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Meme
authors.affiliation: Department of Clinical Specialistic and Stomatological Sciences, Marche Polytechnic University, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Santarelli
authors.affiliation: Department of Surgical Sciences, L'Aquila University, L'Aquila, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Marzo
authors.affiliation: Department of Clinical Specialistic and Stomatological Sciences, Marche Polytechnic University, Ancona, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Emanuelli
authors.affiliation: Department of Maxillo-Facial Surgery, University of Verona, Verona, Italy.
authors.forename: P F
authors.initials: PF
authors.lastname: Nocini
authors.affiliation: Department of Maxillo-Facial Surgery, University of Verona, Verona, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Bertossi
authors.affiliation: Department of Clinical Specialistic and Stomatological Sciences, Marche Polytechnic University, Ancona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Putignano
authors.affiliation: Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dioguardi
authors.affiliation: Department of Clinical and Experimental Medicine, Foggia University, Foggia, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Lo Muzio
authors.affiliation: Department of Clinical Specialistic and Stomatological Sciences, Marche Polytechnic University, Ancona, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bambini
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002470:Cell Survival; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000187:drug effects; D020849:Raloxifene Hydrochloride / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D020849:Raloxifene Hydrochloride; D017886:Durapatite