title: An enantioselective approach to the preparation of chiral sulfones by Ir-catalyzed asymmetric hydrogenation.
abstract: Several chiral sulfonyl compounds were prepared using the iridium catalyzed asymmetric hydrogenation reaction. Vinylic, allylic and homoallylic sulfone substitutions were investigated, and high enantioselectivity is maintained regardless of the location of the olefin with respect to the sulfone. Impressive stereoselectivity was obtained for dialkyl substitutions, which typically are challenging substrates in the hydrogenation. As expected, the more bulky Z-substrates were hydrogenated slower than the corresponding E isomers, and in slightly lower enantioselectivity.
authors.affiliation: Department of Organic Chemistry, Stockholm University , S-10691 Stockholm, Sweden.
authors.forename: Byron K
authors.initials: BK
authors.lastname: Peters
authors.forename: Taigang
authors.initials: T
authors.lastname: Zhou
authors.forename: Janjira
authors.initials: J
authors.lastname: Rujirawanich
authors.forename: Alban
authors.initials: A
authors.lastname: Cadu
authors.forename: Thishana
authors.initials: T
authors.lastname: Singh
authors.forename: Wangchuk
authors.initials: W
authors.lastname: Rabten
authors.forename: Sutthichat
authors.initials: S
authors.lastname: Kerdphon
authors.forename: Pher G
authors.initials: PG
authors.lastname: Andersson