title: When old hematopoietic stem cells get damaged.
abstract: Hematopoietic stem cells (HSCs) functionally decline and are prone to lineage bias and myeloid malignancies upon aging. Two recent studies (Beerman et al., 2014; Flach et al., 2014) investigate the underlying mechanisms associated with aged HSC phenotypes and highlight DNA damage, replication stress, and ribosomal stress in the process.
authors.affiliation: Institute of Hematology (IUH), INSERM UMR944/CNRS UMR7212, Saint-Louis Hospital and University Paris Diderot, Sorbonne Paris Cité, av Claude Vellefaux 75010, Paris, France. Electronic address: jean.soulier@sls.aphp.fr.
authors.forename: Jean
authors.initials: J
authors.lastname: Soulier
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*