title: Magnetic resonance volumetry of the hippocampus in familial spontaneous epileptic cats.
abstract: A strain of familial spontaneous epileptic cats (FSECs) with typical limbic seizures was identified in 2010. The electroencephalographic features suggested that an epileptogenic zone is present in the mesial temporal structures (i.e., amygdala and/or hippocampus). In this study, visual evaluations and quantitative analyses were performed by using 3D MR hippocampal volumetry in comparing FSECs with age-matched controls. Visual hippocampal asymmetries were seen in 8 of 14 (57.1%) FSECs. The FSEC group showed a significantly higher asymmetric ratio (4.15%) than the control group (0.99%). The smaller side of hippocampal volume (HV) (0.206 cm(3)) in FSECs was significantly smaller than the mean HV in controls (0.227 cm(3)). However, the means of left and right HVs and total HVs in FSECs showed no differences because the laterality of hippocampal atrophy was different in each individual. Therefore, since FSECs represent a true model of spontaneous epilepsy, hippocampal volumetry should be evaluated in each individual as well as in human patients. The significant asymmetry of HV suggests the potential for hippocampal atrophy in FSECs.
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Shunta
authors.initials: S
authors.lastname: Mizoguchi
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan. Electronic address: disk-hsgw@nvlu.ac.jp.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hasegawa
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuwabara
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hamamoto
authors.affiliation: Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Science, Graduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yoyoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Fukie
authors.initials: F
authors.lastname: Ogawa
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Aki
authors.initials: A
authors.lastname: Fujiwara
authors.affiliation: Laboratory of Veterinary Clinical Pathobiology, Department of Veterinary Science, Graduate School of Agricultural and Life Science, The University of Tokyo, 1-1-1 Yoyoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: Naoaki
authors.initials: N
authors.lastname: Matsuki
authors.affiliation: Department of Clinical Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyounanchou, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Fujita
mesh_terms: D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D004827:Epilepsy / Q000235:genetics / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male
keywords: Animal model; Cats; Genetic epilepsy; Hippocampal volumetry; MRI; Mesial temporal epilepsy