title: Metabolic profiling of Vitex agnus castus leaves, fruits and sprouts: analysis by LC/ESI/(QqQ)MS and (HR) LC/ESI/(Orbitrap)/MS n.
abstract: Food supplements based on Vitex agnus castus L. (Verbenaceae) fruits, also known as chasteberry, are routinely used by women against somatic and psychic premenstrual symptoms such as depression, sadness or irritability. With the aim of highlighting the differences in the chemical profiles of cultivated fruits and different parts of wild plants (fruits, leaves and sprouts) of V. agnus castus, a method concerning with the quali-quantitative study of the derived hydroalcoholic extracts was carried out by using high-performance liquid chromatography coupled to electrospray negative ionization Orbitrap multicollisional high resolution mass spectrometry (LC/ESI/(Orbitrap)MS(n)) and high-performance liquid chromatography coupled to electrospray negative ionization triple quadrupole tandem mass spectrometry (LC/ESI/(QqQ)MS) in multiple reaction monitoring (MRM) mode.
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Mari
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Montoro
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors.forename: Gilda
authors.initials: G
authors.lastname: D'Urso
authors.affiliation: Dipartimento di Agronomia e Gestione dell'Agroecosistema, Università di Pisa, Via S. Michele degli Scalzi 2, 56124 Pisa, Italy.
authors.forename: Mario
authors.initials: M
authors.lastname: Macchia
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy.
authors.forename: Cosimo
authors.initials: C
authors.lastname: Pizza
authors.affiliation: Dipartimento di Farmacia, Università degli Studi di Salerno, Via Giovanni Paolo II, 84084 Fisciano, Salerno, Italy. Electronic address: piacente@unisa.it.
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005638:Fruit / Q000378:metabolism; D018515:Plant Leaves / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D053719:Tandem Mass Spectrometry; D020950:Vitex / Q000378:metabolism*
keywords: LC/ESI/(Orbitrap)MS(n); LC/ESI/(QqQ)MS/MS; Multiple reaction monitoring (MRM); Quality control; Vitex agnus castus fruits, leaves and sprouts