title: Impulse control disorder and rapid eye movement sleep behavior disorder in Parkinson's disease.
abstract: BACKGROUND
  The relationship between ICD and RBD is still not yet understood and the results from the current literature are contradictory in PD. We aimed to explore the association between rapid eye movement (REM) sleep behavior disorder (RBD) and impulse control disorder in Parkinson's disease.
  
  
  METHODS
  Ninety-eight non-demented patients with Parkinson's disease underwent one night of video-polysomnography recording. The diagnosis of RBD was established according to clinical and polysomnographic criteria. Impulse control disorders were determined by a gold standard, semi-structured diagnostic interview.
  
  
  RESULTS
  Half of the patients (n = 49) reported clinical history of RBD while polysomnographic diagnosis of RBD was confirmed in 31.6% of the patients (n = 31). At least one impulse control disorder was identified in 21.4% of patients, 22.6% with RBD and 20.9% without. Logistic regression controlling for potential confounders indicated that both clinical RBD (OR = 0.34, 95% CI = 0.07-1.48, P = 0.15) and polysomnographic confirmed RBD diagnoses (OR = 0.1.28, 95% CI = 0.31-5.33, P = 0.34) were not associated with impulse control disorder.
  
  
  CONCLUSIONS
  In Parkinson's disease, REM Sleep Behavior Disorder is not associated with impulse control disorder. The results of our study do not support the notion that PSG-confirmed RBD and ICD share a common pathophysiology.
authors.affiliation: Centre d'Investigation clinique, Centre Hospitalier Universitaire Montpellier, France; EuroMov, Laboratoire Movement to Health - M2H, Université Montpellier 1, France. Electronic address: bayardsophie@yahoo.fr.
authors.forename: Sophie
authors.initials: S
authors.lastname: Bayard
authors.affiliation: Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac, Montpellier, France; Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France; Inserm, U1061, Montpellier, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Dauvilliers
authors.affiliation: Department of Neurology, Shanghai Huashan Hospital, Shangai Fudan University, Shangai, China.
authors.forename: Huan
authors.initials: H
authors.lastname: Yu
authors.affiliation: Unité des Troubles du Sommeil, Hôpital Gui-de-Chauliac, Montpellier, France; Laboratoire Epsylon, EA 4556, Universités Montpellier, Montpellier, France.
authors.forename: Muriel
authors.initials: M
authors.lastname: Croisier-Langenier
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Alexia
authors.initials: A
authors.lastname: Rossignol
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Charif
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Geny
authors.affiliation: Service de Neurologie, Hôpital Gui de Chauliac, Montpellier, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Carlander
authors.affiliation: EuroMov, Laboratoire Movement to Health - M2H, Université Montpellier 1, France; Pôle Sommeil et Neurologie, Clinique Beau Soleil, Montpellier, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Cochen De Cock
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000175:diagnosis / Q000209:etiology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D017286:Polysomnography; D020187:REM Sleep Behavior Disorder / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
keywords: Impulse control disorder; Parkinson's disease; Rapid eye movement sleep behavior disorder