title: Second primary malignant peripheral nerve sheath tumor of the paranasal sinuses after nasopharynx carcinoma.
abstract: Malignant peripheral nerve sheath tumors are uncommon neoplasms that arise out of Schwann cells from the peripheral nerves, which rarely occur in the paranasal sinuses and nasal cavity. Especially with the increasing long-term survival of patients with nasopharynx carcinoma, second primary cancers can be diagnosed. Second primary cancers are not uncommon in patients with the prior radiation therapy. However, malignant peripheral nerve sheath tumor in the head and neck region after radiation is an exceedingly rare condition. We report the first case of malignant peripheral nerve sheath tumor of the paranasal sinuses as a second primary malignancy in a patient treated with radiation therapy for nasopharyngeal carcinoma 10 years ago.
authors.affiliation: From the Departments of *Otorhinolaryngology, and †Pathology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Eryilmaz
authors.forename: Yasin Kürşad
authors.initials: YK
authors.lastname: Varsak
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Gul
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Etli
mesh_terms: D002277:Carcinoma; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000473:pathology*; D016609:Neoplasms, Second Primary; D018317:Nerve Sheath Neoplasms / Q000473:pathology*; D009669:Nose Neoplasms / Q000473:pathology*; D010256:Paranasal Sinuses / Q000473:pathology*