title: Metabolic asthma: is there a link between obesity, diabetes, and asthma?
abstract: Childhood asthma and obesity have reached epidemic proportions worldwide, and the latter is also contributing to increasing rates of related metabolic disorders, such as diabetes. However, the relationship between asthma, obesity, and abnormal metabolism is not well understood nor has it been adequately explored in children. This article discusses the concept of metabolic asthma and the recent hypothesis that early derangement in lipid and glucose metabolism is independently associated with increased risk for asthma.
authors.affiliation: Pediatric Institute and Children's Hospital, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: Miriam K
authors.initials: MK
authors.lastname: Perez
authors.affiliation: Pediatric Institute and Children's Hospital, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address: PIEDIMG@ccf.org.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piedimonte
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism; D000818:Animals; D001249:Asthma / Q000453:epidemiology* / Q000378:metabolism*; D002648:Child; D016207:Cytokines / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008168:Lung / Q000502:physiology; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism*; D015995:Prevalence; D058408:Th1-Th2 Balance; D014807:Vitamin D / Q000378:metabolism
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D014807:Vitamin D
keywords: Body mass index; Fetal programming; Lung development; Metabolic syndrome