title: [Review of experimental models: sinusitis in rabbits].
abstract: BACKGROUND
  In order to better understand the pathophysiology of rhinosinusitis, several attempts have been made to create the disease in an animal model. Among the studied rodents each has its advantages and disadvantages. Rabbits are considered more appropriate for studies that require surgical manipulation or invasive procedures.
  
  
  OBJECTIVE
  To evaluate the most viable experimental model of rhinosinusitis in rabbits to be adopted in future studies.
  
  
  METHODS
  An electronic search for studies with experimental models of rhinosinusitis in rabbits published in English and Portuguese between July of 1967 and January of 2013 was conducted in Medline, Pub Med, Cochrane, and CAPES databases, using the keywords "sinusitis", "rabbits", and "polyps".
  
  
  RESULTS
  A total of 256 studies were retrieved, but in accordance with the inclusion and exclusion criteria, only ten studies were selected. Many different methods of response assessment were used in these studies.
  
  
  CONCLUSIONS
  To date, there is no ideal experimental model for induction of acute or chronic rhinosinusitis in rabbits, but the rhinogenic model appears to be the most viable option for the continuity of studies of the disease.
authors.affiliation: Fundação Arnaldo Vieira de Carvalho, Faculdade de Ciências Médicas da Santa Casa de São Paulo (FCMSCSP), São Paulo, SP, Brazil; Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: André Coura
authors.initials: AC
authors.lastname: Perez
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil; Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Guilherme Pietrucci
authors.initials: GP
authors.lastname: Buzatto
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil; Irmandade de Misericórdia de Campinas, Campinas, SP, Brazil.
authors.forename: Ivan de Picole
authors.initials: Ide P
authors.lastname: Dantas
authors.affiliation: Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: João Vicente
authors.initials: JV
authors.lastname: Dorgam
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Fabiana Cardoso Pereira
authors.initials: FC
authors.lastname: Valera
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
authors.forename: Edwin
authors.initials: E
authors.lastname: Tamashiro
authors.affiliation: Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address: wtalima@frnrp.usp.br.
authors.forename: Wilma Terezinha Anselmo
authors.initials: WT
authors.lastname: Lima
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D011817:Rabbits; D012220:Rhinitis / Q000503:physiopathology*; D012852:Sinusitis / Q000503:physiopathology*
keywords: Coelhos; Polyps; Pólipos; Rabbits; Sinusite; Sinusitis