title: Microvascular density, CD68 and tryptase expression in human diffuse large B-cell lymphoma.
abstract: Diffuse Large B-cell Lymphoma (DLBCL) is the most common form of Non-Hodgkin lymphoma characterized by clinical and biological heterogeneity attributable both to the tumor cells and the complex tumor-microenvironment surrounding them. Tumor-associated macrophages (TAMs) and mast cells are two major components of the tumor inflammatory infiltrate with a definite role in enhancing tumor angiogenesis. In this study, we have investigated CD68 and tryptase expression and their relationship with microvascular density (MVD) in chemo-resistant and chemosensitive patients affected by DLBCL. CD68 and tryptase expression as well as MVD were increased in chemo-resistant patients when compared with chemosensitive patients. Tryptase expression showed a positive correlation with MVD, supporting a role for mast cell in DLBCL tumor angiogenesis, while CD68 correlation with MVD was not significant, indicating a different role for TAMs than angiogenesis in DLBCL.
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Marinaccio
authors.affiliation: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ingravallo
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Gaudio
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Italy.
authors.forename: Tommasina
authors.initials: T
authors.lastname: Perrone
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy.
authors.forename: Beatrice
authors.initials: B
authors.lastname: Nico
authors.affiliation: Department of Emergency and Transplantation, Pathology Section, University of Bari Medical School, Bari, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maoirano
authors.affiliation: Department of Emergency and Transplantation, Hematology Section, University of Bari Medical School, Italy.
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.affiliation: Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy; National Cancer Institute "Giovanni Paolo II", Bari, Italy. Electronic address: domenico.ribatti@uniba.it.
authors.forename: Domenico
authors.initials: D
authors.lastname: Ribatti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000276:immunology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology*; D005260:Female; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D053802:Tryptases / Q000378:metabolism*; D059016:Tumor Microenvironment; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D053802:Tryptases; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: Diffuse Large B-Cell Lymphoma; Macrophages; Mast cells; Microvascular density