title: Antioxidant, antimicrobial, toxicity and analgesic properties of ethanol extract of Solena amplexicaulis root.
abstract: BACKGROUND
  This study was subjected to investigate different pharmacological properties of ethanol extract of Solena amplexicaulis root.
  
  
  RESULTS
  The extract contains flavonoid, alkaloid, saponin and steroid compounds. The extract exhibited excellent antioxidant activity in DPPH radical scavenging activity. The extract also showed potent activity in brine shrimp lethality bioassay. The LC50 value was found to 44.677 μg/ml. The extract showed better anti-bacterial activity against gram-negative bacteria. In antifungal assay, the maximum 79.31% of anti-mycotic activity was observed against Aspergillus ochraceus while minimum 44.2% against Rhizopus oryzae. MIC value ranged between 1500-3000 μg/ml. The extract was found moderately toxic with a 24-hr LD50 value of 81.47 mg/kg in Swiss albino mice. The degree of inhibition by the ethanolic extract of the root was found less than that of standard analgesic drug diclofenac sodium. The extract also showed moderate anti-inflammatory and antinociceptive activity and anti-diabetic property. Reducing power of the extract was comparable with standard ascorbic acid. Moderate in vitro thrombolytic activity, lipid peroxidation inhibition property, metal chelating ability and stress-protective activity was also observed.
  
  
  CONCLUSIONS
  Ethanol extract of Solena amplexicaulis root can be valuable for treatment of different diseases.
authors.forename: Md Golam
authors.initials: MG
authors.lastname: Kabir
authors.forename: Md Monsor
authors.initials: MM
authors.lastname: Rahman
authors.forename: Nazim Uddin
authors.initials: NU
authors.lastname: Ahmed
authors.forename: Md
authors.initials: M
authors.lastname: Fakruddin
authors.forename: Saiful
authors.initials: S
authors.lastname: Islam
authors.forename: Reaz Mohammad
authors.initials: RM
authors.lastname: Mazumdar
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D001230:Aspergillus / Q000187:drug effects; D001407:Bacillus / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology; D019662:Cucurbitaceae / Q000737:chemistry*; D005343:Fibrinolytic Agents / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007928:Lethal Dose 50; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D019163:Reducing Agents / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012760:Shigella / Q000187:drug effects
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D000975:Antioxidants; D002614:Chelating Agents; D005343:Fibrinolytic Agents; D016166:Free Radical Scavengers; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D019163:Reducing Agents