title: Breast cancer presenting as paraneoplastic erythroderma: an extremely rare case.
abstract: The skin may exhibit the first clinical evidence of a systemic disease and may provide the first clues to a diagnosis in malignancies. Erythroderma is defined as generalized redness and scaling and it is a clinical manifestation of a variety of underlying diseases including, rarely, solid tumors. Breast cancer is associated with a variety of skin paraneoplastic manifestations like acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, dermatomyositis, systemic sclerosis, and scleroderma. However, in the literature, the correlation of erythroderma with breast cancer is quite infrequent. Here, we describe a case of a 76-year-old woman who presented with a paraneoplastic manifestation of erythroderma due to breast cancer.
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Ioannis
authors.identifier: 0000-0002-6816-9764
authors.initials: I
authors.lastname: Protopsaltis
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Aspasia
authors.identifier: 0000-0002-0464-7624
authors.initials: A
authors.lastname: Drossou
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Katsantonis
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Roussos
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Kassiani
authors.initials: K
authors.lastname: Manoludaki
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Miltiadis
authors.identifier: 0000-0003-0081-4525
authors.initials: M
authors.lastname: Arvanitis
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Athanasia
authors.identifier: 0000-0002-7596-4942
authors.initials: A
authors.lastname: Papazafiropoulou
authors.affiliation: Department of Internal Medicine, Tzaneio General Hospital of Piraeus, 1 Zanni & Afentouli Street, 185 36 Piraeus, Greece.
authors.forename: Stavros
authors.initials: S
authors.lastname: Antonopoulos