title: Peroxisome proliferator-activated receptor gamma in the colon: inflammation and innate antimicrobial immunity.
abstract: Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor, originally described in adipose tissue, which controls the expression of a large number of regulatory genes in lipid metabolism and insulin sensitization. Well known by endocrinologists, thiazolidinedionesare classical PPARγ synthetic agonists, which were currently used as insulin-sensitizing agents in the treatment of type 2 diabetes. Although the clinical benefits of thiazolidinediones in treating metabolic disorders have been clearly demonstrated, studies performed in animal models of colitis and in patients with ulcerative colitis have also revealed the key roles of PPARγ activation in the regulation of inflammation and immune response, notably in the colon through epithelial cells.
authors.affiliation: *INSERM U995 †Université Lille Nord de France ‡CHU Lille, Service des maladies de l'appareil digestif et de la nutrition, Hôpital Claude Huriez, Lille, France.
authors.forename: Silvia
authors.initials: S
authors.lastname: Speca
authors.forename: Laurent
authors.initials: L
authors.lastname: Dubuquoy
authors.forename: Pierre
authors.initials: P
authors.lastname: Desreumaux
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001419:Bacteria / Q000276:immunology / Q000378:metabolism*; D003106:Colon / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D047495:PPAR gamma / Q000819:agonists / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D047495:PPAR gamma; D045162:Thiazolidinediones