title: [Selenium metabolism in patients with severe multiple trauma].
abstract: OBJECTIVE
  To define a relation between the selenium level and the risk of the development of nosocomial pneumonia in patients with severe multiple trauma depending on the trauma severity and the volume of blood loss.
  
  
  METHODS
  We measured serum selenium concentration in 40 patients with severe multiple trauma. The ISS score was used to estimate the trauma severity. Patients were divided into 2 groups: group I--25 patients without pneumonia, group II--15 patients with pneumonia. The volume of blood loss was estimated in each group. The oxidative stress was estimated by means of the antioxidant index.
  
  
  RESULTS
  For selected groups the significant difference (P < 0.05) in the volume of blood loss was detected. It was shown the significant decrease of selenium concentration (P < 0.05) in both groups in comparison with control for all testing time points (the 6-12 hrs, 24 hrs, 3 and 5-7 days). The mean of selenium concentration in group II was significantly lower in comparison to the group I. A significant difference of selenium concentrations (P < 0.05) between groups were detected on the 6-12 hrs and day 3 from the trauma onset. The antioxidant index was significantly lower in the group II within the 6-12 hrs, 12-24 hrs and 5-7 days (P < 0.05) in comparison to group I.
  
  
  CONCLUSIONS
  The severe multiple trauma and severe blood loss lead to a selenium deficiency in the blood serum starting with the first hours from the trauma onset, which leads to the critical level of selenium concentration by the Ist day's end after trauma. It also leads to a pronounced oxidative stress that is reflected in the antioxidant index dynamics. Thus serum selenium concentration may be included in the set of the early prognostic detectors to detect infectious pulmonary complications development at severe multiple trauma, and it could be the basis for the decision to take early prophylaxis using selenium medications.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Zaĭnudinov
authors.forename: A K
authors.initials: AK
authors.lastname: Shabanov
authors.forename: S N
authors.initials: SN
authors.lastname: Zorin
authors.forename: A N
authors.initials: AN
authors.lastname: Kuzovlev
authors.forename: G Iu
authors.initials: GIu
authors.lastname: Mal'tsev
authors.forename: Ia B
authors.initials: IaB
authors.lastname: Azarov
authors.forename: I V
authors.initials: IV
authors.lastname: Vorozhko
authors.forename: O A
authors.initials: OA
authors.lastname: Grebenchikov
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D003428:Cross Infection / Q000097:blood* / Q000209:etiology; D006470:Hemorrhage / Q000097:blood* / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000150:complications; D018410:Pneumonia, Bacterial / Q000097:blood* / Q000209:etiology; D012643:Selenium / Q000097:blood / Q000378:metabolism*; D015599:Trauma Severity Indices; D055815:Young Adult
chemical_list: D000975:Antioxidants; D012643:Selenium