title: Effect of methylprednisolone on mammalian neuronal networks in vitro.
abstract: Glucocorticosteroids (GCS) are widely used for the treatment of neurological diseases, e.g. multiple sclerosis. High levels of GCS are toxic to the central nervous system and can produce adverse effects. The effect of methylprednisolone (MP) on mammalian neuronal networks was studied in vitro. We demonstrate a dose-dependent excitatory effect of MP on cultured neuronal networks, followed by a shut-down of electrical activity using the microelectrode array technique.
authors.affiliation: Department of Neurology, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany, Matthias.wittstock@med.uni-rostock.de.
authors.forename: Matthias
authors.initials: M
authors.lastname: Wittstock
authors.forename: Paulus S
authors.initials: PS
authors.lastname: Rommer
authors.forename: Florian
authors.initials: F
authors.lastname: Schiffmann
authors.forename: Konstantin
authors.initials: K
authors.lastname: Jügelt
authors.forename: Simone
authors.initials: S
authors.lastname: Stüwe
authors.forename: Reiner
authors.initials: R
authors.lastname: Benecke
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schiffmann
authors.forename: Uwe K
authors.initials: UK
authors.lastname: Zettl
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002478:Cells, Cultured; D008775:Methylprednisolone / Q000494:pharmacology*; D051379:Mice; D009415:Nerve Net / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D013116:Spinal Cord / Q000166:cytology / Q000187:drug effects / Q000502:physiology
chemical_list: D008775:Methylprednisolone