title: Bioactive constituents of oleanane-type triterpene saponins from the roots of Glycyrrhiza glabra.
abstract: Three new oleanane-type triterpene saponins, namely licorice-saponin M3 (1), licorice-saponin N4 (2), and licorice-saponin O4 (3), an artificial product (4), as well as five known triterpene glucuronides (5-9), were isolated from the roots of Glycyrrhiza glabra L. Their structures were established using 1D and 2D NMR spectroscopy, mass spectrometry, and by comparison with spectroscopic data reported in the literature. The inhibitory effects of the selected compounds on neuraminidase were evaluated, and the preliminary structure-activity relationship was also predicted.
authors.affiliation: a School of Pharmacy, Nanjing University of Chinese Medicine , Nanjing 210023 , China.
authors.forename: Juan-Hua
authors.initials: JH
authors.lastname: Wei
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Zheng
authors.forename: Cun-Yu
authors.initials: CY
authors.lastname: Li
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Tang
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Peng
mesh_terms: D000975:Antioxidants; D006035:Glycyrrhiza / Q000737:chemistry*; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000975:Antioxidants; D012503:Saponins; C000594244:licorice-saponin M3; C000594245:licorice-saponin N4; C000594246:licorice-saponin O4; C413246:oleanane; D009828:Oleanolic Acid; D009439:Neuraminidase
keywords: Glycyrrhiza glabra; Leguminosae; licorice saponin; neuraminidase inhibitory activity; triterpene glucuronides