title: [Bacterial lipopolsaccharides in pathogenesis of gynecological diseases and obstetric complications].
abstract: Analysis of literature data and author studies on the role of lipopolysaccharides (endotoxin) of Gram negative bacteria in women genital tract pathology and obstetric complications is presented. The role of endogenous infection associated with altered microecology of intestinal tract and vaginal biotopes of women in the development of endotoxinemia is discussed. The participation of endotoxin in embryo resorption, delay of intrauterine development and antenatal death of fetus, premature birth, pre-eclampsia, placental dysfunction is examined. The level of endotoxinema and pro-inflammatory cytokines is a marker of chronic endogenous infectious-inflammatory disease of various parts of genital tract with damage of a network of female reproduction system organs.
authors.forename: K M
authors.initials: KM
authors.lastname: Bondarenko
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
mesh_terms: D005260:Female; D005831:Genital Diseases, Female / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology; D006090:Gram-Negative Bacteria / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology / Q000473:pathology*; D014621:Vagina / Q000382:microbiology / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides