title: Breast cancer risk in MEN1 - a cancer genetics perspective.
abstract: The tumour spectrum associated with multiple endocrine neoplasia type 1 (MEN1) has been known for many years. New data suggest that females with MEN1 may face an additional, hitherto unrecognized, risk of early-onset breast cancer. The menin protein is certainly known to have a role in regulating oestrogen receptor activity; but how robust are the data linking MEN1 to breast cancer? This article examines the published data from the viewpoint of a cancer geneticist and considers whether there really is a justifiable indication for enhanced breast surveillance in women with MEN1.
authors.affiliation: Northern Genetics Service, Newcastle Upon Tyne, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors
chemical_list: C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins