title: Chimera: a Bioconductor package for secondary analysis of fusion products.
abstract: Chimera is a Bioconductor package that organizes, annotates, analyses and validates fusions reported by different fusion detection tools; current implementation can deal with output from bellerophontes, chimeraScan, deFuse, fusionCatcher, FusionFinder, FusionHunter, FusionMap, mapSplice, Rsubread, tophat-fusion and STAR. The core of Chimera is a fusion data structure that can store fusion events detected with any of the aforementioned tools. Fusions are then easily manipulated with standard R functions or through the set of functionalities specifically developed in Chimera with the aim of supporting the user in managing fusions and discriminating false-positive results.
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Beccuti
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Carrara
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Cordero
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lazzarato
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Donatelli
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Nadalin
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Policriti
authors.affiliation: Department of Computer Sciences, University of Torino, C.so Svizzera 185, 10149 Torino, Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126 Torino, Department of Translational Medicine, University of Piemonte Orientale Avogadro, Novara, Unit of Cancer Epidemiology, Department of Medical Sciences, University of Turin, Turin, Department of Computational and Quantitative Biology, UMR 7238 CNRS - Université Pierre et Marie Curie, Paris, France and Department of Mathematics and Computer Science, University of Udine, Italy.
authors.forename: Raffaele A
authors.initials: RA
authors.lastname: Calogero
mesh_terms: D000818:Animals; D050939:Gene Fusion; D058977:Molecular Sequence Annotation; D012984:Software