title: Sleep-disordered breathing, type 2 diabetes and the metabolic syndrome.
abstract: Sleep-disordered breathing (SDB) encompasses a spectrum of conditions that can lead to altered sleep homeostasis. In particular, obstructive sleep apnoea (OSA) is the most common form of SDB and is associated with adverse cardiometabolic manifestations including hypertension, metabolic syndrome and type 2 diabetes, ultimately increasing the risk of cardiovascular disease. The pathophysiological basis of these associations may relate to repeated intermittent hypoxia and fragmented sleep episodes that characterize OSA which drive further mechanisms with adverse metabolic and cardiovascular consequences. The associations of OSA with type 2 diabetes and the metabolic syndrome have been described in studies ranging from epidemiological and observational studies to controlled trials investigating the effects of OSA therapy with continuous positive airway pressure (CPAP). In recent years, there have been rising prevalence rates of diabetes and obesity worldwide. Given the established links between SDB (in particular OSA) with both conditions, understanding the potential influence of OSA on the components of the metabolic syndrome and diabetes and the underlying mechanisms by which such interactions may contribute to metabolic dysregulation are important in order to effectively and holistically manage patients with SDB, type 2 diabetes or the metabolic syndrome. In this article, we review the literature describing the associations, the possible underlying pathophysiological mechanisms linking these conditions and the effects of interventions including CPAP treatment and weight loss.
authors.affiliation: Department of Obesity and Endocrinology, University of Liverpool, Liverpool, UK.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Seetho
authors.affiliation: Department of Obesity and Endocrinology, University of Liverpool, Liverpool, UK j.p.h.wilding@liv.ac.uk.
authors.forename: John P H
authors.initials: JP
authors.lastname: Wilding
mesh_terms: D054392:Adipokines / Q000097:blood; D045422:Continuous Positive Airway Pressure; D003920:Diabetes Mellitus / Q000378:metabolism*; D050171:Dyslipidemias / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System; D007249:Inflammation / Q000378:metabolism; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism; D018384:Oxidative Stress; D010913:Pituitary-Adrenal System; D020181:Sleep Apnea, Obstructive / Q000378:metabolism* / Q000628:therapy*; D015431:Weight Loss
chemical_list: D054392:Adipokines
keywords: Sleep-disordered breathing; metabolic syndrome; obstructive sleep apnoea; type 2 diabetes