title: Juvenile stress alters LTP in ventral hippocampal slices: involvement of noradrenergic mechanisms.
abstract: Childhood adversity is a prominent risk factor for developing stress-related disorders in adulthood. It can be modeled in rodents, where altered stress responses in adulthood have been observed. The ventral hippocampus is thought to be involved in emotional responses and displays a unique modulation of synaptic plasticity following exposure to stress. Here, we investigated the long-term effect of juvenile stress (at postnatal age of 27-29 days) on synaptic plasticity in the ventral and dorsal hippocampus of adult, 3 month old rats. The rats that had experienced juvenile stress expressed impaired LTP in the dorsal hippocampus (DH), while ventral hippocampus (VH) LTP was facilitated. Furthermore, juvenile stress caused reduced sensitivity to the beta-adrenergic agonist isoproterenol (Iso; 1 μM) in the adult DH, while it enhanced its action in VH slices. Further, juvenile stress resulted in an increase in the expression of beta1-adrenergic receptors in the VH but not in the DH, as revealed by western blot. Taken together, the ventral hippocampus expresses a lasting sensitivity to adrenergic modulation, thus likely to affect the emotional response to challenging situations in adulthood.
authors.affiliation: Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel. Electronic address: gaygrig2002@gmail.com.
authors.forename: Gayane
authors.initials: G
authors.lastname: Grigoryan
authors.affiliation: Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: zivardi@gmail.com.
authors.forename: Ziv
authors.initials: Z
authors.lastname: Ardi
authors.affiliation: Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: albrechtannedr@gmail.com.
authors.forename: Anne
authors.initials: A
authors.lastname: Albrecht
authors.affiliation: Sagol Department of Neurobiology, University of Haifa, Mount Carmel, Haifa 3498838, Israel; The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa, Mount Carmel, Haifa 3498838, Israel; Psychology Department, University of Haifa, Mount Carmel, Haifa 3498838, Israel. Electronic address: galrichterlevin@gmail.com.
authors.forename: Gal
authors.initials: G
authors.lastname: Richter-Levin
authors.affiliation: Department of Neurobiology, The Weizmann Institute, Rehovot 76100, Israel. Electronic address: menahem.segal@weizmann.ac.il.
authors.forename: Menahem
authors.initials: M
authors.lastname: Segal
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001703:Biophysics; D003345:Corticosterone / Q000097:blood; D004558:Electric Stimulation; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000378:metabolism; D013315:Stress, Psychological / Q000473:pathology* / Q000503:physiopathology*
chemical_list: D000318:Adrenergic beta-Agonists; D011941:Receptors, Adrenergic; D007545:Isoproterenol; D003345:Corticosterone; D009638:Norepinephrine
keywords: Corticosterone; Dorsal and ventral hippocampus; Juvenile stress; LTP; Norepinephrine