title: Independent and joint effects of the IL-6 and IL-10 gene polymorphisms in pulmonary tuberculosis among the Chinese Han population.
abstract: We investigated the association between interleukin (IL)-6 and IL-10 gene polymorphisms and the susceptibility to pulmonary tuberculosis (PTB). DNA samples were obtained from 191 Han Chinese patients with PTB and 191 healthy control subjects. IL-6 (-572, -174, -597) and IL-10 (-1082, -819) polymorphisms were analyzed using polymerase chain reaction-restriction fragment length polymorphism. The IL-6 -572 C/C and IL-10 -819 T/T genotypes were observed less frequently in the case group than in the control group, with crude odds ratios of 0.591 [95% confidence interval (CI) = 0.381-0.917] and 0.401 (95%CI = 0.257-0.627), respectively. A significant association remained after adjusting for environmental factors in multivariate logistic analysis. The homozygote genotypes of IL-6 -572 and IL-10 -819 had an adjusted OR of 0.565 (95%CI = 0.356-0.898) and 0.341 (95%CI = 0.210-0.553), respectively. These results indicate that the mutant heterozygote IL-10 -1082 A/ G+G/G genotype and the homozygote IL-10 -819 T/T genotype have a combined effect on PTB. These results suggest that the IL-6 -572 C/C and IL-10 -819 T/T genotype polymorphisms are protective factors against PTB.
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China fm_feng@sina.com.
authors.forename: F M
authors.initials: FM
authors.lastname: Feng
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China.
authors.forename: X X
authors.initials: XX
authors.lastname: Liu
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Sun
authors.affiliation: Tangshan Tuberculosis Hospital, Tangshan, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhang
authors.affiliation: College of Nursing and Rehabilitation, Hebei United University, Tangshan, China.
authors.forename: S F
authors.initials: SF
authors.lastname: Sun
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China.
authors.forename: B
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China.
authors.forename: X T
authors.initials: XT
authors.lastname: Wang
authors.affiliation: Key Laboratory of Occupational Health and Safety, School of Public Health, Hebei United University, Tangshan, China.
authors.forename: L J
authors.initials: LJ
authors.lastname: Lu
mesh_terms: D001483:Base Sequence; D016022:Case-Control Studies; D002681:China; D017931:DNA Primers; D005006:Ethnicity; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D017931:DNA Primers; D015850:Interleukin-6; D016753:Interleukin-10