title: The Impact of Uncertainty in Barrett's Esophagus Progression Rates on Hypothetical Screening and Treatment Decisions.
abstract: Estimates for the annual progression rate from Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) vary widely. In this explorative study, we quantified how this uncertainty affects the estimates of effectiveness and efficiency of screening and treatment for EAC.
  
  
  
  We developed 3 versions of the University of Washington / Microsimulation Screening Analysis-EAC model. The models differed with respect to the annual progression rate from BE to EAC (0.12% or 0.42%) and the possibility of spontaneous regression of dysplasia (yes or no). All versions of the model were calibrated to the observed Surveillance, Epidemiology, and End Results esophageal cancer incidence rates from 1998 to 2009. To identify the impact of natural history, we estimated the incidence and deaths prevented as well as numbers needed to screen (NNS) and treat (NNT) of a one-time perfect screening at age 65 years that detected all prevalent BE cases, followed by a perfect treatment intervention.
  
  
  
  Assuming a perfect screening and treatment intervention for all patients with BE, the maximum EAC mortality reduction (64%-66%) and the NNS per death prevented (470-510) were similar across the 3 model versions. However, 3 times more people needed to be treated to prevent 1 death (24 v. 8) in the 0.12% regression model compared with the 0.42% progression model. Restricting treatment to those with dysplasia or only high-grade dysplasia resulted in smaller differences in NNT (2-3 to prevent one EAC case) but wider variation in effectiveness (mortality reduction of 15%-24%).
  
  
  
  The uncertainty in the natural history of the BE to EAC sequence influenced the estimates of effectiveness and efficiency of BE screening and treatment considerably. This uncertainty could seriously hamper decision making about implementing BE screening and treatment interventions.
authors.affiliation: Department of Public Health, Erasmus Medical Center University, Rotterdam, the Netherlands (SK, ILV, AVDS, MVB)
authors.forename: Sonja
authors.initials: S
authors.lastname: Kroep
authors.affiliation: Department of Public Health, Erasmus Medical Center University, Rotterdam, the Netherlands (SK, ILV, AVDS, MVB)
authors.forename: Iris
authors.initials: I
authors.lastname: Lansdorp-Vogelaar
authors.affiliation: Department of Public Health, Erasmus Medical Center University, Rotterdam, the Netherlands (SK, ILV, AVDS, MVB)
authors.forename: Alex
authors.initials: A
authors.lastname: van der Steen
authors.affiliation: Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington, USA (JMI)
authors.forename: John M
authors.initials: JM
authors.lastname: Inadomi
authors.affiliation: Department of Public Health, Erasmus Medical Center University, Rotterdam, the Netherlands (SK, ILV, AVDS, MVB)
authors.forename: Marjolein
authors.initials: M
authors.lastname: van Ballegooijen
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D000368:Aged; D001471:Barrett Esophagus / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002423:Cause of Death; D003661:Decision Support Techniques; D018450:Disease Progression; D055088:Early Detection of Cancer / Q000706:statistics & numerical data*; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D035501:Uncertainty
keywords: Barrett’s esophagus; esophageal adenocarcinoma; incidence; population-based modeling; prevalence; progression rates; screening