title: The discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle.
abstract: Haematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since current treatments such as organophosphates and pyrethroids suffer from field resistance. Isoxazoline oxime ethers represent a new class of γ-aminobutyric acid (GABA) receptor channel blockers which show good activity (LD(90) = 1.0 μg/mL) against horn flies in an in vitro feed assay and have demonstrated efficacy (>90% reduction at 1.0mg/kg) as a topical treatment in a field study.
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA. Electronic address: michael.curtis@zoetis.com.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Curtis
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Nathan
authors.initials: N
authors.lastname: Chubb
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Edmund
authors.initials: E
authors.lastname: Ellsworth
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Goodwin
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Sue
authors.initials: S
authors.lastname: Holzmer
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Koch
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: McTier
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Menon
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Kent
authors.initials: K
authors.lastname: Mills
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Aleah
authors.initials: A
authors.lastname: Pullins
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Tim
authors.initials: T
authors.lastname: Stuk
authors.affiliation: Zoetis Inc., Veterinary Medicine Research and Development, 333 Portage St., Kalamazoo, MI 49007, USA.
authors.forename: Erich
authors.initials: E
authors.lastname: Zinser
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology / Q000517:prevention & control*; D004478:Ectoparasitic Infestations / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D004987:Ethers / Q000737:chemistry; D007306:Insecticides / Q000737:chemistry / Q000494:pharmacology*; D007555:Isoxazoles / Q000737:chemistry; D015394:Molecular Structure; D009117:Muscidae / Q000187:drug effects*; D010091:Oximes / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D004987:Ethers; D007306:Insecticides; D007555:Isoxazoles; D010091:Oximes
keywords: Ectoparasiticides; Horn fly; Isoxazoline; Oxime ether