title: Changes in resting EEG following methadone treatment in opiate addicts.
abstract: OBJECTIVE
  This study investigated the electrophysiological activity associated with methadone maintenance treatment (MMT).
  
  
  METHODS
  The resting EEG spectrum of beta (14.5-30 Hz), alpha (8-13 Hz), theta (4-7.5 Hz) and delta (1.5-3.5 Hz) rhythm were measured in 32 patients undertaking chronic MMT, 17 opiate users and 25 healthy volunteers. Differences in the EEG components of each group were evaluated using a repeated measures Analyses of Variance (ANOVA). Post-hoc comparisons were Bonferroni corrected.
  
  
  RESULTS
  Our results show that either patients undertaking MMT or active opiate users exhibited a significant increase in the power of beta and theta bands relative to healthy control subjects. However, the spectral power of patients undertaking MMT fell between that of current opiate users and healthy control subjects on many regional EEG measures. There was an inverse correlation between the power of beta or theta bands and cognitive performance.
  
  
  CONCLUSIONS
  The abnormal neural electrical activity present in those still using illicit opiates might be reduced following MMT.
  
  
  CONCLUSIONS
  The present findings provide further support for MMT of opiate dependence and demonstrates potentially positive effects of substitution treatment on brain function.
authors.affiliation: Department of Psychology, Auckland University of Technology, New Zealand. Electronic address: gwang@aut.ac.nz.
authors.forename: Grace Y
authors.initials: GY
authors.lastname: Wang
authors.affiliation: Centre for Brain Research, University of Auckland, New Zealand; Department of Psychological Medicine, University of Auckland, New Zealand.
authors.forename: Rob
authors.initials: R
authors.lastname: Kydd
authors.affiliation: Department of Psychological Medicine, University of Auckland, New Zealand.
authors.forename: Trecia A
authors.initials: TA
authors.lastname: Wouldes
authors.affiliation: School of Pharmacy, University of Auckland, New Zealand.
authors.forename: Maree
authors.initials: M
authors.lastname: Jensen
authors.affiliation: Centre for Brain Research, University of Auckland, New Zealand; School of Pharmacy, University of Auckland, New Zealand.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Russell
mesh_terms: D000328:Adult; D058256:Brain Waves / Q000187:drug effects*; D065187:Controlled Before-After Studies; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008564:Membrane Potentials; D008691:Methadone / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D058850:Opiate Substitution Treatment; D009293:Opioid-Related Disorders / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D008691:Methadone
keywords: Methadone; Opiate dependence; Resting EEG