title: An eco-friendly and water mediated product selective synthesis of 2-aminopyrimidines and their in vitro anti-bacterial evaluation.
abstract: A greener water mediated protocol for the efficient synthesis of a library of 2-amino-6-styryl pyrimidines (4) and their dihydro analogues (3) has been reported. Most of the saturated compounds (3) rather than their unsaturated analogues (4) showed better anti-bacterial (in vitro) activity against three human pathogens viz. Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli. In particular, three of them (3 b, 3 i &3 k) exhibited high inhibition against the growth of all the three pathogens comparable with that of the reference drug, tetracycline.
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Sangaraiah
authors.initials: S
authors.lastname: Nagarajan
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Poovan
authors.initials: P
authors.lastname: Shanmugavelan
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Murugan
authors.initials: M
authors.lastname: Sathishkumar
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Ramasamy
authors.initials: R
authors.lastname: Selvi
authors.affiliation: Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India. Electronic address: ramradkrish@yahoo.co.in.
authors.forename: Alagusundaram
authors.initials: A
authors.lastname: Ponnuswamy
authors.affiliation: Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India.
authors.forename: Hariharan
authors.initials: H
authors.lastname: Harikrishnan
authors.affiliation: Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai 625 021, Tamilnadu, India. Electronic address: shanmugaiahv@gmail.com.
authors.forename: Vellasamy
authors.initials: V
authors.lastname: Shanmugaiah
authors.affiliation: Department of Physics, Thanthai Periyar Government Institute of Technology, Vellore 632 002, Tamilnadu, India.
authors.forename: Saminathan
authors.initials: S
authors.lastname: Murugavel
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007711:Klebsiella pneumoniae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D011743:Pyrimidines; D014867:Water; C012180:2-aminopyrimidine
keywords: 2-Aminopyrimidines; Anti-bacterial; Eco-friendly; Product selective; Water mediated