title: [Dysthyroidism with anti-VEGF treatment, a class effect? about one case report].
abstract: Tyrosine-kinase inhibitors are recent therapy used in different neoplastic diseases. Dysthyroidism seems to be a class effect of these drugs with a potentially cross cumulative effect. We describe here the case of a man who first developed dysthyroidism with sunitinib, then a deep and permanent hypothyroidism when axitinib was introduced.
authors.affiliation: Centre régional de pharmacovigilance, CHU de Grenoble, Grenoble, France.
authors.forename: Charles
authors.initials: C
authors.lastname: Khouri
authors.affiliation: Service pharmacie, Centre hospitalier, Bourg en Bresse, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Jean Bart
authors.affiliation: Centre régional de pharmacovigilance, CHU de Grenoble, Grenoble, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Logerot
authors.affiliation: Service de médecine interne, Centre hospitalier, Villefranche-sur-Saône, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Decker-Bellaton
authors.affiliation: Service pharmacie, Centre hospitalier, Villefranche-sur-Saône, France.
authors.forename: Hervé
authors.initials: H
authors.lastname: Bontemps
authors.affiliation: Centre régional de pharmacovigilance, CHU de Grenoble, Grenoble, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Mallaret
mesh_terms: D000328:Adult; D000077784:Axitinib; D057915:Drug Substitution; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000175:diagnosis; D007093:Imidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D007191:Indazoles / Q000009:adverse effects* / Q000627:therapeutic use; D007211:Indoles / Q000009:adverse effects* / Q000627:therapeutic use; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology; D008297:Male; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000145:classification*; D011758:Pyrroles / Q000009:adverse effects* / Q000627:therapeutic use; D000077210:Sunitinib; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D007093:Imidazoles; D007191:Indazoles; D007211:Indoles; D047428:Protein Kinase Inhibitors; D011758:Pyrroles; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000077784:Axitinib; D000077210:Sunitinib