title: Persistent spiking fever in a child with acute myeloid leukemia and disseminated infection with enterovirus.
abstract: We here report a 7 year old acute myeloid leukemia patient with persistent spiking fever likely caused by chronic echovirus 20 infection. After immunoglobulin substitution fevers subsided and the virus was cleared. Enterovirus infection should be considered in immunocompromised patients with unexplained persistent fever.
authors.affiliation: Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: j.murk@umcutrecht.nl.
authors.forename: J L
authors.initials: JL
authors.lastname: Murk
authors.affiliation: Department of Pediatric Oncology/Hematology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: A C
authors.initials: AC
authors.lastname: de Vries
authors.affiliation: Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: C H
authors.initials: CH
authors.lastname: GeurtsvanKessel
authors.affiliation: Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Aron
authors.affiliation: Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
authors.affiliation: Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
authors.forename: K C
authors.initials: KC
authors.lastname: Wolthers
authors.affiliation: Department of Viroscience, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Pediatrics, Subdivision of Infectious Diseases and Immunology, Erasmus University Medical Center, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: P L
authors.initials: PL
authors.lastname: Fraaij
mesh_terms: D002648:Child; D004457:Echovirus Infections / Q000175:diagnosis* / Q000473:pathology*; D029822:Enterovirus B, Human / Q000302:isolation & purification*; D005334:Fever / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous
keywords: Acute myeloid leukemia; Echovirus 20; Enterovirus; Immunoglobulin therapy; Spiking fever