title: Composite alginate hydrogel microparticulate delivery system of zidovudine hydrochloride based on counter ion induced aggregation.
abstract: OBJECTIVE
  The present study deals with preparation of zidovudine loaded microparticle by counter ion induced aggregation method. During this study effect of polyacrylates and hypromellose polymers on release study were investigated.
  
  
  METHODS
  The ion induced aggregated alginate based microparticles were characterized for surface morphology, particle size analysis, drug entrapment study, in-vitro study, Fourier-transform infrared (FTIR) spectroscopy, and differential scanning calorimetry (DSC) study.
  
  
  CONCLUSIONS
  The result showed Eudragit RL-100 (ERL) based formulations had smoother surface as well as their mean particle sizes were found greater compared with Eudragit RS-100 (ERS) microparticles. Furthermore, drug entrapments were found to be more in ERL formulae as compared with ERS. RL3 released 101.05% drug over a period of 8(th) h and followed Higuchi profile and Fickian diffusion. Moreover, data obtained illustrated that, higher amount of quaternary ammonium group, alkali value, and glass transition temperature may be possible reason for improving permeability of ERL based formulations. It was also noticed, hyroxypropyl methylcellulose (HPMC) K4M premium grade polymer sustained drug release more than HPMC K15M. In addition, drug-excipient interaction study was carried out by FTIR and DSC study.
authors.affiliation: Department of Pharmatechnology, Vikas College of Pharmaceutical Sciences, Suryapet, Nalgonda, Andhra Pradesh, India.
authors.forename: Harekrishna
authors.initials: H
authors.lastname: Roy
authors.affiliation: Department of Pharmatechnology, Vikas College of Pharmaceutical Sciences, Suryapet, Nalgonda, Andhra Pradesh, India.
authors.forename: P Venkateswar
authors.initials: PV
authors.lastname: Rao
authors.affiliation: Department of Biosciences and Technology , VIT University, Vellore, Tamil Nadu, India.
authors.forename: Sanjay Kumar
authors.initials: SK
authors.lastname: Panda
authors.affiliation: Formulation Research and Development, FDC Limited, Mumbai, India.
authors.forename: Asim Kumar
authors.initials: AK
authors.lastname: Biswal
authors.affiliation: Department of Biosciences and Technology , VIT University, Vellore, Tamil Nadu, India.
authors.forename: Kirti Ranjan
authors.initials: KR
authors.lastname: Parida
authors.affiliation: Department of Quality and Assurance, Microlabs Ltd., Hosur, Tamil Nadu, India.
authors.forename: Jharana
authors.initials: J
authors.lastname: Dash
keywords: Eudragit RL-100; Higuchi profile; hypromellose; hyroxypropyl methylcellulose K4M premium; microparticle; zidovudine