title: [Life-threatening bleeding during dabigatran treatment because of acute renal failure].
abstract: We report a case where a 64-year-old woman treated with dabigatran developed life-threatening bleeding due to lack of dose adjustment following identification of acute renal failure. Many commonly used drugs, e.g. new oral anticoagulants, digoxin, ACE-inhibitors, antibiotics, are eliminated by the kidneys. The case illustrates that lack of medication reconciliation can lead to serious adverse events in case of deteriorating organ function. The use of medication reconciliation should be performed on a daily basis and special attention should be exercised in case of reduced kidney function.
authors.affiliation: Medicinsk Afdeling, Regionshospitalet Randers, Skovlyvej 1, 8930 Randers. E-mail: henrik.idom@gmail.com.
authors.forename: Henrik Bjørnsgaard
authors.initials: HB
authors.lastname: Madsen
authors.forename: Sophie Constantin
authors.initials: SC
authors.lastname: Lütken
authors.forename: Jonas Agerlund
authors.initials: JA
authors.lastname: Povlsen
authors.forename: Bø
authors.initials: B
authors.lastname: Løfgren
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications*; D000991:Antithrombins / Q000008:administration & dosage / Q000009:adverse effects*; D016638:Critical Illness; D000069604:Dabigatran / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008875:Middle Aged
chemical_list: D000991:Antithrombins; D000069604:Dabigatran