title: Corneal epithelial thickness map in long-term soft contact lenses wearers.
abstract: OBJECTIVE
  To map the corneal epithelial thickness in vivo with Fourier-domain optical coherence tomography in long-term soft contact lens (SCL) wearers.
  
  
  METHODS
  This is a cross-sectional observational study. Forty eyes from 40 normal subjects who had never worn SCL and 40 eyes from 40 SCL wearers who had worn lenses for more than 2 years were enrolled. Corneal epithelium over the entire cornea was topographically imaged using a novel optical coherence tomography system. An epithelial thickness map was automatically generated. Epithelial thicknesses of the central 2-mm, paracentral 2- to 5-mm (P1), and midperipheral 5- to 6-mm (P2) zones were obtained. In addition, the epithelial map variability in P1 and P2 zones, including maximum - minimum (MAX - MIN), map SD, and coefficient of variation (CV), was measured and analyzed.
  
  
  RESULTS
  The average epithelial thickness of the central, P1, and P2 zones was 54.4 ± 1.1 μm, 53.2 ± 2.2 μm, and 52.3 ± 2.0 μm, respectively, in normal eyes and 49.2 ± 1.9 μm, 48.8 ± 2.2 μm, and 48.7 ± 2.8 μm, respectively, in eyes wearing SCL. Compared with normal control subjects, eyes with long-term SCL had significantly thinner epithelial thickness in all three zones (p < 0.05). However, there was no difference in MAX - MIN, SD, and CV of P1 and P2 zones between two groups. In both groups, there was significant difference in the epithelial thickness among different sectors in the paracentral and midperipheral zones.
  
  
  CONCLUSIONS
  There is a decrease in epithelial thickness in subjects who wear SCL long term. Clinicians should take note of the nonuniformity of the paracentral and midperipheral corneal epithelium thicknesses. This method may be useful for detecting early changes in corneal epithelial thickness caused by long-term SCL wear.
authors.affiliation: *MD, PhD †PhD ‡MD Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital (JH, YY, CJ, XS, JX) and Department of Immunology (TQ), Shanghai Medical School, Fudan University, Shanghai, China; School of Life Sciences, Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, China (JH, ZL); and Cornea Division, Jules Stein Eye Institute, University of California, Los Angeles, California (SXD).
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Hong
authors.forename: Tingting
authors.initials: T
authors.lastname: Qian
authors.forename: Yujing
authors.initials: Y
authors.lastname: Yang
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.forename: Zuguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
authors.forename: Sophie X
authors.initials: SX
authors.lastname: Deng
authors.forename: Jianjiang
authors.initials: J
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D003263:Contact Lenses, Hydrophilic; D063171:Corneal Pachymetry; D003430:Cross-Sectional Studies; D019573:Epithelium, Corneal / Q000473:pathology*; D005260:Female; D005583:Fourier Analysis; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D041623:Tomography, Optical Coherence / Q000379:methods; D055815:Young Adult