title: Analysis of salivary antioxidant levels in different clinical staging and histological grading of oral squamous cell carcinoma: noninvasive technique in dentistry.
abstract: OBJECTIVE
  To estimate and Compare of salivary antioxidant level {Uric acid (UA), Glutathione S Transferase (GST) and Superoxide dismutase (SOD)} between healthy control and study group (oral squamous cell carcinoma patients).Further comparison of sub division of study group on the basis of clinical staging and histological grading.
  
  
  METHODS
  The study group consists of 50 cases of squamous cell carcinoma and 50 healthy patients. These parameters were estimated by spectrophotometer. The biochemical values of this study were subjected to statistical analysis i.e. Independent t-test, ANOVA and Tukey test.
  
  
  RESULTS
  UA suggested statistically significant changes in saliva of clinical staging and histological grading of oral squamous cell carcinoma (SCC) patients. Salivary SOD level between well to poorly differentiated SCC showed a progressive increase although it is not statistically significant.
  
  
  CONCLUSIONS
  Salivary analysis of antioxidant is simple, non-invasive technique which may be useful as diagnostic, prognostic and therapeutic marker.
authors.affiliation: Senior Resident, Department of Oral Pathology & Microbiology, Maulana Azad Institute of Dental Sciences , New Delhi, India .
authors.forename: Hanspal
authors.initials: H
authors.lastname: Singh
authors.affiliation: Professor, Head of the Department, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences , Mangalore, Karnataka, India .
authors.forename: Pushparaja
authors.initials: P
authors.lastname: Shetty
authors.affiliation: Reader, Department of Oral Pathology & Microbiology, A.B. Shetty Memorial Institute of Dental Sciences , Mangalore, Karnataka, India .
authors.forename: Sreelatha
authors.initials: S
authors.lastname: S V
authors.affiliation: Senior lecturer, Babu Banarasi Das college of Dental Sciences , Lucknow, Uttar Pradesh, India .
authors.forename: Madvikha
authors.initials: M
authors.lastname: Patidar
keywords: Antioxidant; Clinical staging; Histological grading; Saliva and oral squamous cell carcinoma