title: Elemental analysis in biotechnology.
abstract: This article focuses on analytical strategies integrating atomic spectroscopy in biotechnology. The rationale behind developing such methods is inherently linked to unique features of the key technique in elemental analysis, which is inductively coupled plasma mass spectrometry: (1) the high sensitivity and selectivity of state of the art instrumentation, (2) the possibility of accurate absolute quantification even in complex matrices, (3) the capability of combining elemental detectors with chromatographic separation methods and the versatility of the latter approach, (4) the complementarity of inorganic and organic mass spectrometry, (5) the multi-element capability and finally (6) the capability of isotopic analysis. The article highlights the most recent bio-analytical developments exploiting these methodological advantages and shows the potential in biotechnological applications.
authors.affiliation: Department of Chemistry, University of Natural Resources and Life Sciences - BOKU Vienna, Muthgasse 18, 1190 Vienna, Austria; Austrian Centre of Industrial Biotechnology (ACIB), Muthgasse 18, 1190 Vienna, Austria.
authors.forename: Stephan
authors.initials: S
authors.lastname: Hann
authors.affiliation: Department of Applied Chemistry, Faculty of Food Science, Corvinus University of Budapest, Villányi út 29-33, 1118 Budapest, Hungary.
authors.forename: Mihaly
authors.initials: M
authors.lastname: Dernovics
authors.affiliation: Austrian Centre of Industrial Biotechnology (ACIB), Muthgasse 18, 1190 Vienna, Austria; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Währingerstrasse 38, 1190 Vienna, Austria. Electronic address: gunda.koellensperger@univie.ac.at.
authors.forename: Gunda
authors.initials: G
authors.lastname: Koellensperger
mesh_terms: D000818:Animals; D001709:Biotechnology / Q000379:methods*; D006801:Humans; D007554:Isotopes / Q000032:analysis; D013058:Mass Spectrometry / Q000295:instrumentation / Q000379:methods*
chemical_list: D007554:Isotopes