title: Surgical decompression of painful diabetic peripheral neuropathy: the role of pain distribution.
abstract: OBJECTIVE
  To investigate the effect of surgical decompression on painful diabetic peripheral neuropathy (DPN) patients and discuss the role which pain distribution and characterization play in the management of painful DPN as well as the underlying mechanism involved.
  
  
  METHODS
  A total of 306 patients with painful diabetic lower-extremity neuropathy were treated with Dellon surgical nerve decompression in our department. Clinical evaluation including Visual analogue scale (VAS), Brief Pain Inventory Short Form for diabetic peripheral neuropathy (BPI-DPN) questionnaire, two-point discrimination (2-PD), nerve conduction velocity (NCV) and high-resolution ultrasonography (cross-sectional area, CSA) were performed in all cases preoperatively, and at 6 month intervals for 2 years post-decompression. The patients who underwent surgery were retrospectively assigned into two subgroups (focal and diffuse pain) according to the distribution of the diabetic neuropathic pain. The control group included 92 painful DPN patients without surgery.
  
  
  RESULTS
  The levels of VAS, scores in BPI-DPN, 2-PD, NCV results and CSA were all improved in surgical group when compared to the control group (P<0.05). More improvement of VAS, scores in BPI-DPN and CSA was observed in focal pain group than that in diffuse group (P<0.05).
  
  
  CONCLUSIONS
  Efficacy of decompression of multiple lower-extremity peripheral nerves in patients with painful diabetic neuropathy was confirmed in this study. While both focal and diffuse group could benefit from surgical decompression, pain relief and morphological restoration could be better achieved in focal group.
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Chenlong
authors.initials: C
authors.lastname: Liao
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Wenchuan
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Qiufeng
authors.initials: Q
authors.lastname: Ma
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Guowei
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, XinHua Hospital, affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
authors.forename: Wenxiang
authors.initials: W
authors.lastname: Zhong
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019299:Decompression, Surgical / Q000379:methods*; D003929:Diabetic Neuropathies / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D035002:Lower Extremity; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010146:Pain / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D010147:Pain Measurement / Q000379:methods*; D010525:Peripheral Nerves / Q000601:surgery*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires