title: Evaluation of a Unani polyherbal formulation (Tiryaqe wabai) as an immunostimulator in elderly persons.
abstract: OBJECTIVE
  Elderly subjects have a dysregulation of immune response mainly due to the changes in cell - mediated immunity. Due to their weakened immune response, the elderly are at increased risk of infection and related complications. In Unani medicine Tiryaq wabai was used for the prevention of epidemic diseases during outbreaks, but it has not been explored scientifically so far. The study was aimed to evaluate the immune-stimulating effect of Tiryaq wabai in elderly.
  
  
  METHODS
  A randomized placebo controlled trial was conducted at National Institute of Unani Medicine Hospital, Bangalore. Thirty immunocompromised elderly persons were selected on the basis of clinical examination considering parameters like history of recurrent infection, unexplained weight loss, persistent diarrhea etc. They were randomly assigned, 20 in test and 10 in the control group. Tiryaq wabai was given to test group 500 mg orally thrice in a week for 45 days. Placebo was given orally to the control group at a dose of 500 mg thrice in a week for 45 days. Response was assessed by total leucocyte count (TLC), lymphocyte percentage, absolute lymphocyte count (ALC), CD4 and CD8 count. The results were analyzed statistically using Graph Pad InStat 3.
  
  
  RESULTS
  The test drug showed statistically significant increase in TLC (P < 0.001), lymphocyte percentage (P < 0.001),ALC (P < 0.001), CD4 count (P < 0.001) in comparison to control group, but increase in CD8 count was not statistically significant. No major adverse effect was observed throughout the study.
  
  
  CONCLUSIONS
  The findings outlined above indicate immune- stimulating activity of Tiryaq wabai and supports its use in conditions where immunostimulation is required and thus is suggestive of therapeutic usefulness.
authors.affiliation: Departments of Tahaffuzi wa Samaji Tib National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Zar
authors.initials: Z
authors.lastname: Nigar
authors.affiliation: Departments of Tahaffuzi wa Samaji Tib National Institute of Unani Medicine, Bengaluru, Karnataka, India.
authors.forename: Malik
authors.initials: M
authors.lastname: Itrat
keywords: Aging; T-lymphocytes; Unani medicine; immune-senescence