title: Predicting post-vaccination autoimmunity: who might be at risk?
abstract: Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated that autoimmunity could be triggered or enhanced by the vaccine immunogen contents, as well as by adjuvants, which are used to increase the immune reaction to the immunogen. Fortunately, vaccination-related ASIA is uncommon. Yet, by defining individuals at risk we may further limit the number of individuals developing post-vaccination ASIA. In this perspective we defined four groups of individuals who might be susceptible to develop vaccination-induced ASIA: patients with prior post-vaccination autoimmune phenomena, patients with a medical history of autoimmunity, patients with a history of allergic reactions, and individuals who are prone to develop autoimmunity (having a family history of autoimmune diseases; asymptomatic carriers of autoantibodies; carrying certain genetic profiles, etc.).
authors.affiliation: Department of Clinical Medicine and Rheumatology, Campus Bio-Medico University, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Soriano
authors.affiliation: Department of Internal Medicine A, Shaare Zedek Medical Center, and the Hebrew University Medical School, Jerusalem, Israel. Electronic address: nesherg@szmc.org.il.
authors.forename: Gideon
authors.initials: G
authors.lastname: Nesher
authors.affiliation: The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Sackler Faculty of Medicine, Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel.
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Shoenfeld
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000453:epidemiology; D015551:Autoimmunity; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology; D012306:Risk; D014611:Vaccination / Q000009:adverse effects*
keywords: Adjuvants; Allergy; Autoantibodies; Autoimmunity; Vaccine