title: Arsenic-containing hydrocarbons are toxic in the in vivo model Drosophila melanogaster.
abstract: Arsenic-containing hydrocarbons (AsHC) constitute one group of arsenolipids that have been identified in seafood. In this first in vivo toxicity study for AsHCs, we show that AsHCs exert toxic effects in Drosophila melanogaster in a concentration range similar to that of arsenite. In contrast to arsenite, however, AsHCs cause developmental toxicity in the late developmental stages of Drosophila melanogaster. This work illustrates the need for a full characterisation of the toxicity of AsHCs in experimental animals to finally assess the risk to human health related to the presence of arsenolipids in seafood.
authors.affiliation: Graduate School of Chemistry, University of Muenster, Wilhelm-Klemm-Straße 10, 48149 Muenster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Meyer
authors.forename: J
authors.initials: J
authors.lastname: Schulz
authors.forename: A
authors.initials: A
authors.lastname: Jeibmann
authors.forename: M S
authors.initials: MS
authors.lastname: Taleshi
authors.forename: F
authors.initials: F
authors.lastname: Ebert
authors.forename: K A
authors.initials: KA
authors.lastname: Francesconi
authors.forename: T
authors.initials: T
authors.lastname: Schwerdtle
mesh_terms: D000818:Animals; D001151:Arsenic / Q000737:chemistry / Q000633:toxicity*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D006838:Hydrocarbons / Q000737:chemistry / Q000633:toxicity*; D008018:Life Cycle Stages / Q000187:drug effects; D008297:Male; D008345:Manganese; D008954:Models, Biological
chemical_list: D006838:Hydrocarbons; D008345:Manganese; D001151:Arsenic