title: p16 promoter hypermethylation is associated with increased risk of nasopharyngeal carcinoma.
abstract: The present study aimed to investigate the effects of p16 hypermethylation on the risk of nasopharyngeal carcinoma (NPC) quantitatively, through a meta-analysis of available case-control studies including malignant and normal NPC tissue samples. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between p16 hypermethylation and NPC risk. A total of 9 studies, including 406 NPC and 376 control cases, were identified for meta-analysis. Statistically significant ORs of p16 hypermethylation were obtained from the NPC and control groups (OR=19.53; 95% CI: 9.54-39.97; P=0.685). The meta-analysis indicated that p16 hypermethylation significantly increases NPC risk.
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Hongguo
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Laboratory of Molecular Genetics of Aging and Tumor, Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, P.R. China.
authors.forename: Wenru
authors.initials: W
authors.lastname: Tang
keywords: meta-analysis; nasopharyngeal cancer; p16 hypermethylation