title: [Optimization of treatment of septic wounds in patients with diabetic foot ulcers].
abstract: An analysis of complex examination and treatment was made in 116 patients with necrotic suppurative complications. Patients were divided into two statistically homogeneous groups. An ointment "Levomekol" was used in control group and immobilized forms of chlorhexidine bigluconate was applied in the main group. The dynamics of traumatic process course was learned by planimetric, bacteriological and cytological methods. The percentage of area reduction of wounds in the main group was higher, than in control group: on the third day--on 1.59%, on the fifth day--on 3.16%, on the seventh day--on 5.86%, on the tenth day--on 6.83%, on the fourteenth day--on 7.80%, on the twenty-first day--on 7.62%. A microbial contamination of wounds (generated colony units in 1 g of tissue) was less, than in control group on the third day of treatment--on 1.6 x 10(6), on the fifth day--on 26.2 x 10(5), on the seventh day--on 77.8 x 10, on the tenth day--on 2.2 x 10(4) and on the fifteenth day--on 0.3 x 10(3) (p < 0.05). The number of granulocytes was less in main group: on the third day--on 11.8%, on the fifth day--on 14.2%, on the seventh day--on 8.8%, on the tenth day--on 5.2%. The quantity of fibroblasts (a number of reparative cells) was more in wounds of the main group in the same terms: 2.9%, 5.8%, 3,.6%, 4.4%, respectively. Thus, the treatment of suppurative wounds by the immobilized form of chlorhexidine bigluconate was proved pathogenetically reasonable and effective.
authors.forename: B S
authors.initials: BS
authors.lastname: Sukovatykh
authors.forename: T A
authors.initials: TA
authors.lastname: Pankrusheva
authors.forename: S A
authors.initials: SA
authors.lastname: Abramova
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D001419:Bacteria / Q000145:classification / Q000187:drug effects*; D002710:Chlorhexidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D003131:Combined Modality Therapy / Q000379:methods; D003646:Debridement / Q000379:methods*; D017719:Diabetic Foot / Q000150:complications / Q000382:microbiology / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009824:Ointments; D011108:Polymers; D013492:Suppuration; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014946:Wound Infection / Q000209:etiology / Q000503:physiopathology / Q000628:therapy
chemical_list: D000891:Anti-Infective Agents, Local; D009824:Ointments; D011108:Polymers; C010882:chlorhexidine gluconate; D002710:Chlorhexidine