title: The validity of self-reported medication adherence as an outcome in clinical trials of adherence-promotion interventions: Findings from the MACH14 study.
abstract: In medication adherence-promotion trials, participants in the intervention arm are often cognizant of the researcher's aim to improve adherence; this may lead to their inflating reports of their own adherence compared to control arm participants. Using data from 1,247 HIV-positive participants across eight U.S. Studies in the Multi-site Adherence Collaboration on HIV (MACH14) collaboration, we evaluated the validity of self-reported adherence by examining whether its association with two more objective outcomes [1], electronically monitored adherence and [2] viral load, varied by study arm. After adjusting for potential confounders, there was no evidence of greater overestimation of self-reported adherence among intervention arm participants, supporting its potential as a trial outcome indicator.
authors.affiliation: Department of Psychology, University of Washington, Box 351525, Seattle, WA, 98195, USA, jsimoni@uw.edu.
authors.forename: Jane M
authors.initials: JM
authors.lastname: Simoni
authors.forename: David
authors.initials: D
authors.lastname: Huh
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ira B
authors.initials: IB
authors.lastname: Wilson
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Reynolds
authors.forename: Robert H
authors.initials: RH
authors.lastname: Remien
authors.forename: Kathy
authors.initials: K
authors.lastname: Goggin
authors.forename: Robert
authors.initials: R
authors.lastname: Gross
authors.forename: Marc I
authors.initials: MI
authors.lastname: Rosen
authors.forename: Neil
authors.initials: N
authors.lastname: Schneiderman
authors.forename: Julia
authors.initials: J
authors.lastname: Arnsten
authors.forename: Carol E
authors.initials: CE
authors.lastname: Golin
authors.forename: Judith A
authors.initials: JA
authors.lastname: Erlen
authors.forename: David R
authors.initials: DR
authors.lastname: Bangsberg
authors.forename: Honghu
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1; D006293:Health Promotion; D006801:Humans; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D015203:Reproducibility of Results; D057566:Self Report; D014481:United States / Q000453:epidemiology; D019562:Viral Load; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents