title: Efficacy of a lutein-based dye (Phacodyne™) for visualizing anterior capsulorhexis during cataract surgery by phacoemulsification.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of a novel lutein-based dye for the anterior capsulorhexis during phacoemulsification in cataract surgery in humans.
  
  
  METHODS
  Twenty-five eyes from 25 patients were operated by 25 different surgeons who performed continuous circular capsulorhexis (CCC) guided by a lutein-based dye (Phacodyne™) during cataract surgery by phacoemulsification. A questionnaire assessed the surgeon’s opinion regarding the efficacy of the dye. Follow-up examinations were performed at 1, 7, and 30 days post-surgery. Eyes were evaluated by full ophthalmic examination, corneal topography/pachymetry, and corneal endothelial cell count.
  
  
  RESULTS
  As revealed by the answers to the questionnaire, the dye facilitated the CCC procedure in all eyes. Baseline nuclear cataract classification (according to the Lens Opacities Classification System III; LOCS III) was 3.24 (± 1.12). Preoperative BCVA (logMAR) was 0.89 ± 0.59 and improved to 0.23 ± 0.22 on day 30 after surgery. The intraocular pressure (IOP) remained stable and the inflammatory reaction subsided in all cases within the first 7 days after surgery. The pre-operative values of corneal pachymetry and IOP were similar to those found on follow-up day 30. Loss in endothelial cell number was similar to earlier reports.
  
  
  CONCLUSIONS
  Phacodyne™ was efficient when used for anterior capsulorhexis during cataract surgery by phacoemulsification and
authors.forename: Lucas Monferrari Monteiro
authors.initials: LM
authors.lastname: Vianna
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Cohen
authors.forename: Cristina
authors.initials: C
authors.lastname: Muccioli
authors.forename: Acácio
authors.initials: A
authors.lastname: Lima
authors.forename: Diogo
authors.initials: D
authors.lastname: Sousa-Martins
authors.forename: Maurício
authors.initials: M
authors.lastname: Maia
authors.forename: Rubens
authors.initials: R
authors.lastname: Belfort
mesh_terms: D057866:Anterior Capsule of the Lens / Q000187:drug effects / Q000601:surgery*; D019923:Capsulorhexis / Q000379:methods*; D002452:Cell Count; D004396:Coloring Agents; D063171:Corneal Pachymetry; D042783:Endothelial Cells; D005260:Female; D006801:Humans; D007429:Intraocular Pressure; D014975:Lutein; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014343:Trypan Blue
chemical_list: D004396:Coloring Agents; D014343:Trypan Blue; D014975:Lutein