title: Liver fat contents, abdominal adiposity and insulin resistance in non-diabetic prevalent hemodialysis patients.
abstract: BACKGROUND
  The liver fat contents and abdominal adiposity correlate well with insulin resistance (IR) in the general population. However, the relationship between liver fat content, abdominal adiposity and IR in non-diabetic hemodialysis (HD) patients remains unclear. This study aimed to clarify the associations among these factors.
  
  
  METHODS
  This is a cross-sectional, observational study. All patients received abdominal ultrasound for liver fat content. Abdominal adiposity was quantified with the conicity index (Ci) and waist circumference (WC). We checked the homeostasis model assessment for insulin resistance index (HOMA-IR) for IR.
  
  
  RESULTS
  A total of 112 patients (60 women) were analyzed. Subjects with higher liver fat contents and WC had higher IR indices. But Ci did not correlate with IR indices. In both the multi-variable linear regression model and the logistic regression model, only higher liver fat content predicted a severe IR status.
  
  
  CONCLUSIONS
  Liver fat contents have a remarkable correlation with IR; however, abdominal adiposity, measured either by Ci or WC, dose not independently correlate with IR in non-diabetic prevalent HD patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Hung-Yuan
authors.initials: HY
authors.lastname: Chen
authors.forename: Chien-Chu
authors.initials: CC
authors.lastname: Lin
authors.forename: Yen-Ling
authors.initials: YL
authors.lastname: Chiu
authors.forename: Shih-Ping
authors.initials: SP
authors.lastname: Hsu
authors.forename: Mei-Fen
authors.initials: MF
authors.lastname: Pai
authors.forename: Ju-Yeh
authors.initials: JY
authors.lastname: Yang
authors.forename: Hon-Yen
authors.initials: HY
authors.lastname: Wu
authors.forename: Yu-Sen
authors.initials: YS
authors.lastname: Peng
mesh_terms: D000005:Abdomen / Q000000981:diagnostic imaging / Q000473:pathology; D050154:Adiposity; D000368:Aged; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D014463:Ultrasonography; D055105:Waist Circumference