title: Nanoparticles prepared from porous silicon nanowires for bio-imaging and sonodynamic therapy.
abstract: Evaluation of cytotoxicity, photoluminescence, bio-imaging, and sonosensitizing properties of silicon nanoparticles (SiNPs) prepared by ultrasound grinding of porous silicon nanowires (SiNWs) have been investigated. SiNWs were formed by metal (silver)-assisted wet chemical etching of heavily boron-doped (100)-oriented single crystalline silicon wafers. The prepared SiNWs and aqueous suspensions of SiNPs exhibit efficient room temperature photoluminescence (PL) in the spectral region of 600 to 1,000 nm that is explained by the radiative recombination of excitons confined in small silicon nanocrystals, from which SiNWs and SiNPs consist of. On the one hand, in vitro studies have demonstrated low cytotoxicity of SiNPs and possibilities of their bio-imaging applications. On the other hand, it has been found that SiNPs can act as efficient sensitizers of ultrasound-induced suppression of the viability of Hep-2 cancer cells.
authors.affiliation: Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
authors.forename: Liubov A
authors.initials: LA
authors.lastname: Osminkina
authors.affiliation: Leibniz Institute of Photonic Technology, Jena 07745, Germany.
authors.forename: Vladimir A
authors.initials: VA
authors.lastname: Sivakov
authors.affiliation: Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
authors.forename: Grigory A
authors.initials: GA
authors.lastname: Mysov
authors.affiliation: Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
authors.forename: Veronika A
authors.initials: VA
authors.lastname: Georgobiani
authors.affiliation: Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
authors.forename: Ulyana А
authors.initials: UА
authors.lastname: Natashina
authors.affiliation: Leibniz Institute of Photonic Technology, Jena 07745, Germany.
authors.forename: Florian
authors.initials: F
authors.lastname: Talkenberg
authors.affiliation: Institute of Theoretical and Experimental Biophysics, RAS, Pushino 142290, Russia.
authors.forename: Valery V
authors.initials: VV
authors.lastname: Solovyev
authors.affiliation: Institute of Theoretical and Experimental Biophysics, RAS, Pushino 142290, Russia.
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Kudryavtsev
authors.affiliation: Department of Physics, Lomonosov Moscow State University, 119991, Moscow, Russia.
authors.forename: Victor Yu
authors.initials: VY
authors.lastname: Timoshenko
keywords: Bio-imaging; Cytotoxicity; Photoluminescence; Silicon nanoparticles; Silicon nanowires; Sonodynamic therapy; Theranostic