title: Visible-light-induced chemoselective reductive decarboxylative alkynylation under biomolecule-compatible conditions.
abstract: We report a visible-light-induced reductive decarboxylative C(sp(3))-C(sp) bond coupling reaction to construct aryl, alkyl and silyl substituted alkynes at room temperature in organic solvents or neutral aqueous solutions. This chemoselective alkynylation was compatible with various functional groups and biomolecules, and did not affect the protein enzyme activity.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China. yiyunchen@sioc.ac.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Qi
authors.forename: Chenchen
authors.initials: C
authors.lastname: Hu
authors.forename: Yiyun
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000478:Alkylation / Q000528:radiation effects; D000480:Alkynes / Q000737:chemistry* / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism*; D003653:Decarboxylation / Q000528:radiation effects; D006801:Humans; D008027:Light; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000528:radiation effects
chemical_list: D000480:Alkynes; D002256:Carbonic Anhydrases