title: Bulky mediastinal aspergillosis mimicking cancer in an immunocompetent patient.
abstract: We describe the case of a previously healthy 42-year-old woman who presented with a chronic cough and occasional night sweats. Radiologic exploration showed a bulky mediastinal mass surrounding the aortic arch, associated with a left subclavicular lymph node and a cerebral round lesion, mimicking a disseminated lung cancer. Surgical left subclavicular and computed tomography-guided mediastinal biopsy specimens showed granulomatous patterns. Mycologic culture of both samples grew Aspergillus flavus. Resolution was obtained after 9 months of oral voriconazole therapy.
authors.affiliation: Département Thoracique, Institut Mutualiste Montsouris, Paris, France; Assistance Publique-hôpitaux de Paris, CHU Bicêtre, Service des maladies infectieuses et tropicales, Le Kremlin-Bicêtre, France. Electronic address: jean-baptiste.stern@imm.fr.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Stern
authors.affiliation: Assistance Publique-hôpitaux de Paris, CHU Bicêtre, Service des maladies infectieuses et tropicales, Le Kremlin-Bicêtre, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wyplosz
authors.affiliation: Département d'anatomopathologie, Institut Mutualiste Montsouris, Paris, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Validire
authors.affiliation: Assistance Publique-hôpitaux de Paris, CHU Bicêtre, Service de Mycologie et Parasitologie, Le Kremlin-Bicêtre, France.
authors.forename: Adela
authors.initials: A
authors.lastname: Angoulvant
authors.affiliation: Département d'imagerie médicale, Institut Mutualiste Montsouris, Paris, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Fregeville
authors.affiliation: Département Thoracique, Institut Mutualiste Montsouris, Paris, France.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Caliandro
authors.affiliation: Département Thoracique, Institut Mutualiste Montsouris, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gossot
mesh_terms: D000328:Adult; D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D001231:Aspergillus flavus / Q000302:isolation & purification*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008477:Mediastinal Diseases / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D065819:Voriconazole / Q000627:therapeutic use
chemical_list: D065819:Voriconazole