title: Correlation between EGFR mutation status and computed tomography features in patients with advanced pulmonary adenocarcinoma.
abstract: OBJECTIVE
  To correlate computed tomography (CT) imaging features and epidermal growth factor receptor (EGFR) mutation status in patients with advanced lung adenocarcinoma.
  
  
  METHODS
  Patients with advanced pulmonary adenocarcinoma who were diagnosed between January 1, 2009 and December 31, 2011 and who had available chest CT and their tumors analyzed for EGFR mutations at a university hospital were enrolled in this retrospective study. Two radiologists independently evaluated the CT images and recorded the target lesion's size, shape, margin, density, and the presence or absence of an air bronchogram and calcification.
  
  
  RESULTS
  One hundred and forty-nine patients were enrolled into this study (66 men, 83 women), with a mean age of 63±11 years (range 32 to 89 y). Seventy-eight (52.3%) patients had EGFR mutations. The tumors in the patients harboring no EGFR mutations (EGFR wild type) were larger than in those whose tumors harbored EGFR mutations (P=0.01). An irregular shape was more common in the tumors with wild-type EGFR (P=0.01), and an oval shape was more common in tumors with EGFR mutations. Tumors with exon 21 mutations were larger than those with exon 19 deletions (P=0.02). Air bronchograms were more common in tumors with exon 19 deletions than in those with wild-type EGFR or exon 21 mutations (P=0.004 and 0.01, respectively). Calcification was more common in the tumors with wild-type EGFR than in those with EGFR mutations (P=0.03).
  
  
  CONCLUSIONS
  Adenocarcinomas with wild-type EGFR were significantly associated with larger tumors and an irregular shape. In particular, calcification was more common in the tumors with wild-type EGFR than in those with EGFR mutations. In addition, air bronchograms were more common in the tumors with exon 19 deletions.
authors.affiliation: *Department of Medical Imaging, Kaohsiung Medical University Hospital †Department of Radiology, Faculty of Medicine, Graduate Institute of Medicine College of Medicine ‡Division of Hematology and Oncology §Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine ¶Department of Surgery, Division of Chest Surgery #Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital ∥Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan.
authors.forename: Jui-Sheng
authors.initials: JS
authors.lastname: Hsu
authors.forename: Ming-Shyan
authors.initials: MS
authors.lastname: Huang
authors.forename: Chiao-Yun
authors.initials: CY
authors.lastname: Chen
authors.forename: Gin-Chung
authors.initials: GC
authors.lastname: Liu
authors.forename: Ta-Chih
authors.initials: TC
authors.lastname: Liu
authors.forename: Inn-Wen
authors.initials: IW
authors.lastname: Chong
authors.forename: Shah-Hwa
authors.initials: SH
authors.lastname: Chou
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Yang
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000235:genetics; D000077192:Adenocarcinoma of Lung; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D015588:Observer Variation; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D066246:ErbB Receptors