title: A general palladium-catalyzed method for alkylation of heteroarenes using secondary and tertiary alkyl halides.
abstract: A general alkylation of heterocycles using a simple palladium catalyst is reported. Most classes of heterocycles, including indoles and pyridines, efficiently coupled with unactivated secondary and tertiary alkyl halides. An alkyl radical addition to neutral heteroarenes is most likely involved.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, 637371 (Singapore).
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Wu
authors.forename: Jessica Wei Ting
authors.initials: JW
authors.lastname: See
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Hajime
authors.initials: H
authors.lastname: Hirao
authors.forename: Julien
authors.initials: J
authors.lastname: Roger
authors.forename: Jean-Cyrille
authors.initials: JC
authors.lastname: Hierso
authors.forename: Jianrong Steve
authors.initials: JS
authors.lastname: Zhou
mesh_terms: D000478:Alkylation; D006219:Halogens / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D006219:Halogens; D006571:Heterocyclic Compounds; D010165:Palladium
keywords: CH activation; alkyl radicals; heterocycles; palladium; single electron transfer