title: [Comparative pharmacokinetics of syringin, eleutheroside E and isofraxidin in rat plasma after intravenous administration of each monomer and Ciwujia injection].
abstract: To compare the pharmacokinetics of syringin, eleutheroside E and isofraxidin after intravenous administration of each monomer and Ciwujia injection. Twenty-four Sprague-Dawley rats were randomly divided into four groups and intravenously administrated with syringin, eleutheroside E, isofraxidin, and Ciwujia injection, respectively. The concentrations of the three components in rat plasma were determined by LC-MS/MS. DAS 2.0 software was applied to calculate the pharmacokinetic parameters while the SPSS 17.0 software was used for statistical analysis. Significant difference (P < 0.05) was found between each monomer and the injection on the main pharmacokinetic parameters such as AUC, CL and t1,/2. Compared with the injection, the group treated with the syringin has obvious decrease in AUC, and increase in CL while the group treated with eleutheroside E has obvious increase in AUC, and decrease in CL The t1/2 of isofraxidin was prolonged in Ciwujia injection. Pharmacokinetic characters of the ingredients in the injection varied greatly from the monomer. Other constituents in the injection may have an impact on the pharmacokinetic profiles of these three components.
authors.forename: Hui-Xia
authors.initials: HX
authors.lastname: Fan
authors.forename: Zhi-Peng
authors.initials: ZP
authors.lastname: Deng
authors.forename: Hao
authors.initials: H
authors.lastname: Zhong
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Xu
authors.forename: Qing-Qiang
authors.initials: QQ
authors.lastname: Yao
mesh_terms: D061605:Administration, Intravenous; D000818:Animals; D003374:Coumarins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005960:Glucosides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D017705:Lignans / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D010666:Phenylpropionates / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003374:Coumarins; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D017705:Lignans; D010666:Phenylpropionates; C008182:isofraxidin; C421885:eleutheroside E; C028305:syringin