title: General synthesis of substituted 1,2-dihydropyridines.
abstract: A general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp(3) position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol.
authors.affiliation: Departamento de Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología, CSIC , Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Tejedor
authors.forename: Leandro
authors.initials: L
authors.lastname: Cotos
authors.forename: Gabriela
authors.initials: G
authors.lastname: Méndez-Abt
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D000588:Amines / Q000737:chemistry*; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry; D000432:Methanol / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000588:Amines; D004095:Dihydropyridines; D014753:Vinyl Compounds; C100195:vinyl ether; D014050:Toluene; D000432:Methanol