title: Acute renal failure in a patient with mantle cell lymphoma.
abstract: Mantle cell lymphoma is a rare form of B-cell lymphoma. We present a 54-year-old gentleman with mantle cell lymphoma. It was diagnosed based on the demonstration of B-cell antigens CD20 and CD5. It was further confirmed by demonstration of overexpression of cyclin D1 on these atypical lymphocytes in the immunohistochemical staining. He also had acute renal failure and proteinuria. Renal biopsy revealed crescents and lymphomatous infiltration of tubulointerstitium. The presence of infiltrating cells with similar markers in both the lymph node and the kidney confirmed the infiltration of kidney with lymphomatous cells. Our present patient, after a thorough literature search, is found to be the second one with a glomerular lesion and tubulointerstitial infiltration by malignant lymphoma cells.
authors.affiliation: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Peddi
authors.affiliation: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Rapur
authors.initials: R
authors.lastname: Ram
authors.affiliation: Department of Medical Oncology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Sudheer Reddy
authors.initials: SR
authors.lastname: Kataru
authors.affiliation: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Krishna Kishore
authors.initials: KK
authors.lastname: Chennu
authors.affiliation: Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Rukumangadha
authors.initials: R
authors.lastname: Nandyala
authors.affiliation: Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: Radhika
authors.initials: R
authors.lastname: Kottu
authors.affiliation: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.
authors.forename: V Siva
authors.initials: VS
authors.lastname: Kumar
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*
keywords: Acute renal failure; crescentic glomerulonephritis; lymphomatous infiltration; mantle cell lymphoma; renal biopsy