title: IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population.
abstract: We investigated the relationships between single nucleotide polymorphisms (SNPs) of the interleukin (IL)-6 gene 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) and coronary artery disease (CAD) risk in a Chinese population. This case-control study recruited 296 CAD patients and 327 controls between January 2009 and May 2012. Genotyping of IL-6 174 G>C (rs1800795), 572 G>C (rs1800796), and 597 G/A (rs1800797) was performed on a 384-well plate format using the Sequenom MassARRAY platform. CAD patients were more likely to be older and male, with a higher body mass index, diabetes, and hypertension, and presented higher triglycerides, and lower total cholesterol, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol. We found that the IL-6 174CC genotype was associated with a significantly increased risk of CAD compared to the wild-type GG genotype in a codominant model [odds ratio (95% confidence interval) = 1.94 (1.13-3.37)], whereas IL-6 174 G>C polymorphisms presented an increased risk of CAD in dominant and recessive models. However, we did not find that the IL-6 572 CC and 597 AA genotypes were correlated with an increased risk of CAD. IL-6 174 G>C rs1800795 was associated with CAD risk in a Chinese population. Further large-scale studies are required to determine whether IL-6 SNPs interact with environmental factors in the development of CAD.
authors.affiliation: Department of Cardiovasology, The First Hospital of Jilin University, Changchun, China.
authors.forename: G Q
authors.initials: GQ
authors.lastname: Sun
authors.affiliation: Department of Cardiovasology, The First Hospital of Jilin University, Changchun, China.
authors.forename: G D
authors.initials: GD
authors.lastname: Wu
authors.affiliation: Department of Pathology and Physiology, School of Basic Medical Science, Jilin University, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Department of Cardiovasology, The First Hospital of Jilin University, Changchun, China.
authors.forename: B
authors.initials: B
authors.lastname: Du
authors.affiliation: Changchun Medical College, Changchun, China liyubocmc@163.com.
authors.forename: Y B
authors.initials: YB
authors.lastname: Li
mesh_terms: D000368:Aged; D002681:China; D003324:Coronary Artery Disease / Q000208:ethnology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D015850:Interleukin-6