title: Preparations for colon capsule endoscopy. Prospective and randomized comparative study between two preparations for colon capsule endoscopy: PEG 2 liters + ascorbic acid versus PEG 4 liters.
abstract: BACKGROUND
  PillCam© colon capsule endoscopy (CCE) enables the study of colonic diseases in a safe and non-invasive way, although there are aspects that need to be improved. Current methods of bowel preparation lead to discordant rates of adequate cleansing and CCE excretion.
  
  
  OBJECTIVE
  To compare the efficacy of colon cleansing using two different regimes (2L PEG plus ascorbic acid versus 4L PEG alone) for PillCam Colon (C2) capsule endoscopy.
  
  
  METHODS
  Fifty eight patients included in this prospective study and randomized to: Group A, PEG plus ascorbic acid regimen (n = 28, 12 F/16 M) or group B, PEG alone regimen (n = 30, 14 F/16 M). The degree of cleansing was categorized into "excellent-good" or "fair-poor", according to Leighton´s recently published preparation scale. CCE excretion rate and colon cleansing were assessed. Patients underwent to PillCam colon of second generation (C2).
  
  
  RESULTS
  Cleansing was considered to be excellent-good in 78 % of cases in group A and in 64 % of cases in group B, with no significant difference between the groups (p = 0.252). Nevertheless, when the grade of cleansing was analyzed in segments, a significant difference was found in the cecum and transverse colon. No differences were observed in the bubble effect between preparations. The excretion rate was 93 % in group A versus 70 % in group B (p = 0.043).
  
  
  CONCLUSIONS
  These results suggest that a 2L PEG plus ascorbic acid regimen is at least as effective as a 4L PEG regimen. This regimen may be considered an effective alternative which would improve compliance because a smaller volume is required.
authors.forename: Federico
authors.initials: F
authors.lastname: Argüelles-Arias
authors.forename: Mileidis
authors.initials: M
authors.lastname: San-Juan-Acosta
authors.forename: Alba
authors.initials: A
authors.lastname: Belda
authors.forename: Josefa María
authors.initials: JM
authors.lastname: García-Montes
authors.forename: Francisco
authors.initials: F
authors.lastname: Pellicer
authors.forename: J
authors.initials: J
authors.lastname: Polo
authors.forename: Ángel
authors.initials: Á
authors.lastname: Caunedo-Álvarez
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Herrerías-Gutiérrez
mesh_terms: D001205:Ascorbic Acid / Q000008:administration & dosage*; D053704:Capsule Endoscopy / Q000379:methods*; D002400:Cathartics / Q000008:administration & dosage*; D003113:Colonoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011300:Preoperative Care; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D002400:Cathartics; D011092:Polyethylene Glycols; D001205:Ascorbic Acid