title: Thrombophilia in patients with chronic immune thrombocytopenia.
abstract: An increased risk of thromboembolic events among patients with chronic immune thrombocytopenia has been reported but is still not fully understood. A thrombophilia panel (factors suspected/known to denote a thrombophilic state or indicate activation of the clotting cascade) was measured in previously treated patients with chronic immune thrombocytopenia enrolled in an eltrombopag trial to assess potential thrombophilia risk markers. Of 167 patients, 136 (81%) had abnormal levels of at least 1 known or suspected thrombosis risk marker or coagulation cascade activation marker. Six patients reported thromboembolic events, and all of these patients had at least two abnormal analytes in the thrombophilia panel. The presence of multiple baseline thrombophilia risk markers support the theory that chronic immune thrombocytopenia is a pro-thrombotic disease.
authors.affiliation: Prince of Wales Hospital, The Chinese University of Hong Kong, Department of Medicine and Therapeutics , Hong Kong , China.
authors.forename: Raymond S M
authors.initials: RS
authors.lastname: Wong
authors.forename: Kalpana
authors.initials: K
authors.lastname: Bakshi
authors.forename: Andres
authors.initials: A
authors.lastname: Brainsky
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001779:Blood Coagulation Factors / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D019851:Thrombophilia / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001779:Blood Coagulation Factors
keywords: Blood coagulation; blood platelets; fibrinolysis; immune thrombocytopenic purpura; thrombosis