title: Elevated serum anti-phosphatidylcholine IgG antibodies in patients with influenza vaccination-associated optic neuritis.
abstract: BACKGROUND
  Because the optic nerve is mainly comprised from phospholipids such as phosphatidylcholine, the association between optic neuritis, anti-phospholipids antibodies and vaccination was examined.
  
  
  METHODS
  Two female pediatric patients suddenly presented bilateral optic neuritis after administration of trivalent inactivated influenza vaccine.
  
  
  METHODS
  These two patients and another 11 patients with central nervous system demyelinating diseases were examined these anti-phospholipids antibodies. And immune histopathology was examined using serum derived from a patient with optic neuritis.
  
  
  RESULTS
  High serum titer of anti-phosphatidylcholine antibody levels were detected during acute phase in patients with optic neuritis. The patient's serum IgG antibodies were found to have stained the capillary endotheliums in the preserved autopsied optic nerve. Patients with optic neuritis had significantly elevated serum levels of anti-phosphatidylcholine antibody in comparison to the other patients without optic neuritis.
  
  
  CONCLUSIONS
  Anti-phosphatidylcholine antibodies may be one of the causes of optic neuritis.
authors.affiliation: Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Oita, Japan. Electronic address: kseigo@oita-u.ac.jp.
authors.forename: Seigo
authors.initials: S
authors.lastname: Korematsu
authors.affiliation: Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyahara
authors.affiliation: Department of Pathology, Brain Research Institute, University of Niigata, Niigata, Japan.
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Kakita
authors.affiliation: Department of Pediatrics and Child Neurology, Oita University Faculty of Medicine, Oita, Japan.
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Izumi
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007252:Influenza Vaccines / Q000009:adverse effects*; D009900:Optic Nerve / Q000473:pathology; D009902:Optic Neuritis / Q000139:chemically induced* / Q000276:immunology; D010713:Phosphatidylcholines / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000009:adverse effects
chemical_list: D017152:Antibodies, Antiphospholipid; D007074:Immunoglobulin G; D007252:Influenza Vaccines; D010713:Phosphatidylcholines; D015164:Vaccines, Inactivated
keywords: Anti-phosphatidylcholine antibody; Central nervous system demyelinating diseases; Influenza vaccine; Optic neuritis