title: Serum levels of sex hormones and expression of their receptors in thyroid tissue in female patients with various types of thyroid neoplasms.
abstract: Previous studies have demonstrated the expression of estrogen receptor (ER) and progesterone receptor (PR) in thyroid cancer; however, little is known regarding the levels of estrogen, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) in serum and the expression of ER, PR, FSH receptor (FSHR), and LH receptor (LHR) in thyroid tissues of patients with different types of thyroid neoplasms. Serum levels of estrogen, progesterone, FSH, and LH were measured by chemiluminescence, and expression of ER, PR, FSHR, and LHR in thyroid tissue was detected by immunohistochemistry in female patients with thyroid adenoma (n = 70), nodular goiter (n = 73), thyroid papillary cancer (n = 149), poorly differentiated thyroid carcinoma (n = 12), or undifferentiated thyroid carcinoma (n = 8) and in normal controls (n = 60). The positive rates of serum estrogen level and ERα expression were significantly greater in patients with various types of thyroid neoplasms than in normal controls. The positive rates of ERβ expression were significantly less in various types of thyroid neoplasms than in normal thyroid tissues, especially in poorly differentiated carcinoma and undifferentiated carcinoma. The negative rates of serum progesterone level and positive rates of PR expression in thyroid tissue were significantly greater in patients with thyroid adenoma, nodular goiter, or thyroid papillary cancer than in normal controls. The positive rates of serum FSH and LH levels and FSHR and LHR expression were significantly greater in the thyroid adenoma group than in other groups. Our findings suggest that thyroid neoplasms might be sex hormone-dependent. The positive expression of ERα and PR often indicates thyroid papillary carcinoma, and the ERβ expression status is important for the diagnosis of poorly differentiated carcinoma and undifferentiated carcinoma. In addition, thyroid adenoma is often accompanied by an increase in serum FSH and LH levels, as well as FSHR and LHR expression. Thus, the combined detection of serum levels of sex hormones and expression of their receptors allows for a differential diagnosis and evaluation of the degree of differentiation among various types of thyroid neoplasms.
authors.affiliation: Department of Thyroid Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Thyroid Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of Thyroid Surgery, First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Xian-Ying
authors.initials: XY
authors.lastname: Meng
authors.affiliation: Department of Immunology, Norman Bethune College of Medicine, Jilin University, Changchun 130021, China.
authors.forename: Zhong-Hui
authors.initials: ZH
authors.lastname: Liu
authors.affiliation: Department of Anesthesia, First Hospital of Jilin University, Changchun 130021, China. Electronic address: dongsu327@sina.com.
authors.forename: Su
authors.initials: S
authors.lastname: Dong
mesh_terms: D000236:Adenoma / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D002291:Carcinoma, Papillary; D016022:Case-Control Studies; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D004967:Estrogens / Q000097:blood; D005260:Female; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006044:Goiter, Nodular / Q000097:blood / Q000175:diagnosis / Q000473:pathology; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011237:Predictive Value of Tests; D011374:Progesterone / Q000097:blood; D011960:Receptors, Estrogen / Q000032:analysis*; D011962:Receptors, FSH / Q000032:analysis*; D011974:Receptors, LH / Q000032:analysis*; D011980:Receptors, Progesterone / Q000032:analysis*; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000737:chemistry*; D013964:Thyroid Neoplasms / Q000097:blood / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D004967:Estrogens; D043373:Follicle Stimulating Hormone, Human; D012739:Gonadal Steroid Hormones; D011960:Receptors, Estrogen; D011962:Receptors, FSH; D011974:Receptors, LH; D011980:Receptors, Progesterone; D011374:Progesterone; D007986:Luteinizing Hormone
keywords: Estrogen; FSH; LH; Progesterone; Thyroid neoplasms