title: The role of the orphan nuclear receptor COUP-TFII in tumorigenesis.
abstract: The chicken ovalbumin upstream promoter transcription factors (COUP-TFs), members of the nuclear receptor superfamily, consist of two highly homologous subtypes, COUP-TFI (EAR-3, NR2F1) and COUP-TFII (ARP-1, NR2F2). They are referred to as orphan receptors because the COUP-TF ligands have yet to be identified. Since the discovery of COUP-TFs in 1986, extensive studies have demonstrated their crucial functions in a variety of developmental processes, such as organogenesis, angiogenesis, and metabolic homeostasis. Recently, emerging evidence has highlighted that COUP-TFs, specifically COUP-TFII, play important roles in tumorigenesis. In this review, we will discuss the critical functions of COUP-TFII in the development of the tumor microenvironment, the progression of various cancers, and its underlying mechanisms.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Mafei
authors.initials: M
authors.lastname: Xu
authors.affiliation: 1] Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA [2] Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai 200025, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Sophia Y
authors.initials: SY
authors.lastname: Tsai
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Ming-jer
authors.initials: MJ
authors.lastname: Tsai
mesh_terms: D000818:Animals; D051837:COUP Transcription Factor II / Q000235:genetics* / Q000378:metabolism*; D063646:Carcinogenesis / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D051837:COUP Transcription Factor II