title: Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk.
abstract: BACKGROUND
  Epidemiological studies of the association between nonsteroidal anti-inflammatory drug (NSAID) intake and the risk of prostate cancer still remain controversial. Therefore, we conducted a meta-analysis to evaluate the potential association between NSAID intake and prostate cancer risk.
  
  
  METHODS
  Eligible studies were retrieved by both computerized searches and reviews of references. Subgroup analyses on country and design of study were also performed. Random or fixed-effect models were used to pool estimates of odds ratios (ORs) with 95% confidence intervals (CIs).
  
  
  RESULTS
  We observed that the intake of aspirin was associated with a marginally decreased risk of prostate cancer (OR = 0.95, 95% CI = 0.93 to 0.98). A similar result was found between nonaspirin NSAIDs and prostate cancer risk (OR = 0.94, 95% CI =0.90 to 0.98). However, a positive relation between all-NSAID intake and prostate cancer risk was observed (OR = 1.18, 95% CI = 1.15 to 1.22).
  
  
  CONCLUSIONS
  We observed a marginally inverse correlation between the intake of aspirin and prostate cancer risk. On the contrary, a positive relationship between all-NSAID intake and prostate cancer was detected. Further research needs to be conducted to better clarify potential biological mechanisms.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Yi-wei
authors.initials: YW
authors.lastname: Lin
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiang-lai
authors.initials: XL
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liang
authors.forename: Zheng-hui
authors.initials: ZH
authors.lastname: Hu
authors.forename: Shi-qi
authors.initials: SQ
authors.lastname: Li
authors.forename: Xiang-yi
authors.initials: XY
authors.lastname: Zheng
authors.affiliation: Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, People's Republic of China. xielp@zjuem.zju.edu.cn.
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Xie
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D006801:Humans; D015994:Incidence; D008297:Male; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal