title: Identification and adjustment of experimental occlusal interference using functional magnetic resonance imaging.
abstract: BACKGROUND
  The purpose of this study was to use functional magnetic resonance imaging (fMRI) to quantify changes in brain activity during experimental occlusal interference.
  
  
  METHODS
  Fourteen healthy volunteers performed a rhythmical tapping occlusion task with experimental occlusal interference of the right molar tooth at 0 mm (no occlusion), 0.5 mm, and 0.75 mm. The blood-oxygen-level dependent (BOLD) signal was quantified using statistical parametric mapping and compared between rest periods and task periods.
  
  
  RESULTS
  In tapping tasks with experimental occlusal interference of 0.75 mm or 0.5 mm, there was clear activation of the contralateral teeth-related primary sensory cortex and Brodmann's area 46. At 0 and 30 minutes after removal of the experimental occlusal interference, the activation clearly appeared in the bilateral teeth-related primary sensory cortices and Brodmann's area 46. At 60 minutes after the removal of the experimental occlusal interference, the activation of Brodmann's area 46 had disappeared, and only the bilateral teeth-related primary sensory cortices were active.
  
  
  CONCLUSIONS
  The present results suggest that adjustments for experimental occlusal interference can be objectively evaluated using fMRI. We expect that this method of evaluating adjustments in occlusal interference, combined with fMRI and the tapping task, could be applied clinically in the future.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Oda
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yoshino
authors.forename: Tatsurou
authors.initials: T
authors.lastname: Tanaka
authors.forename: Shunji
authors.initials: S
authors.lastname: Shiiba
authors.forename: Eri
authors.initials: E
authors.lastname: Makihara
authors.forename: Ikuya
authors.initials: I
authors.lastname: Miyamoto
authors.forename: Shinnosuke
authors.initials: S
authors.lastname: Nogami
authors.forename: Shinji
authors.initials: S
authors.lastname: Kito
authors.forename: Nao
authors.initials: N
authors.lastname: Wakasugi-Sato
authors.forename: Shinobu
authors.initials: S
authors.lastname: Matsumoto-Takeda
authors.forename: Shun
authors.initials: S
authors.lastname: Nishimura
authors.forename: Keita
authors.initials: K
authors.lastname: Murakami
authors.forename: Masahiro
authors.initials: M
authors.lastname: Koga
authors.forename: Shigenori
authors.initials: S
authors.lastname: Kawagishi
authors.forename: Izumi
authors.initials: I
authors.lastname: Yoshioka
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Masumi
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Kimura
authors.affiliation: Division of Oral and Maxillofacial Radiology, Kyushu Dental University, Kitakyushu, Japan. rad-mori@kyu-dent.ac.jp.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000328:Adult; D001921:Brain / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology; D003769:Dental Occlusion, Traumatic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D013788:Thalamus / Q000502:physiology; D013997:Time Factors; D014070:Tooth / Q000294:innervation; D055698:Touch Perception / Q000502:physiology
chemical_list: D010100:Oxygen