title: Impact of the adequacy of energy intake on intensive care unit mortality in patients receiving enteral nutrition.
abstract: OBJECTIVE
  To investigate the relationship between adequacy of energy intake and intensive care unit mortality in patients receiving exclusive enteral nutrition therapy.
  
  
  METHODS
  Observational and prospective study conducted during 2008 and 2009. Patients above 18 years with exclusive enteral nutrition therapy for at least 72 hours were included. The adequacy of energy intake was estimated by the administered/prescribed ratio. Non-conditional logistic regression was used to assess the relationship between predictive variables (adequacy of energy intake, APACHE II, gender, age, and intensive care unit length of stay) and intensive care unit mortality.
  
  
  RESULTS
  Sixty-three patients (mean 58 years, 27% mortality) were included, 47.6% of whom received more than 90% of the energy prescribed (mean adequacy 88.2%). Mean energy balance was -190 kcal/day. Significant associations between death in the intensive care unit and the variables age and intensive care unit length of stay were observed, after removing the variables adequacy of energy intake, APACHE II, gender and age during the modeling process.
  
  
  CONCLUSIONS
  In our study, adequacy of energy intake did not affect intensive care unit mortality. Carefully followed enteral nutrition protocols, resulting in an administered/prescribed ratio above 70%, are apparently not sufficient to impact the mortality rates in the intensive care unit. Therefore, it may not be necessary to achieve 100% of the targeted energy, considering the high frequency of enteral feeding interruptions due to gastrointestinal intolerance and fasting for tests and procedures. Additional research is needed to identify the optimal energy intake for improved outcomes and reduced costs.
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Natália Sanchez
authors.initials: NS
authors.lastname: Oliveira
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Lúcia
authors.initials: L
authors.lastname: Caruso
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Denise Pimentel
authors.initials: DP
authors.lastname: Bergamaschi
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Flávia de Conti
authors.initials: Fde C
authors.lastname: Cartolano
authors.affiliation: Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Francisco Garcia
authors.initials: FG
authors.lastname: Soriano