title: Long-term results of palliative stent placement for acute malignant colonic obstruction.
abstract: BACKGROUND
  Endoscopic placement of self-expanding-metal-stents (SEMS) is widely performed as palliative treatment for acute malignant colonic obstruction. There is ongoing debate regarding risks and benefits associated with SEMS placement. This study aimed to evaluate long-term outcomes of palliative SEMS placement in patients presenting with acute malignant colonic obstruction.
  
  
  METHODS
  A prospectively collected patient cohort (2005-2013) from a general teaching hospital was used. In this hospital, all consecutive patients presenting with acute malignant large bowel obstruction are treated with endoscopic SEMS placement. Only colon cancer patients who underwent palliative SEMS placement were selected.
  
  
  RESULTS
  In total, 48 patients were included. The technical and short-term clinical success rates were 91 % (44/48) and 85 % (36/48), respectively. SEMS-related mortality occurred in 6/48 patients (13 %) (early n = 4, late n = 2) and was caused by SEMS-related perforation in all cases. The SEMS-related morbidity rate was 38 % (18/48) (early n = 7, late n = 11). Endoscopic re-intervention was performed 14 times and 13 patients eventually underwent surgical treatment during follow-up. The stoma-formation rate was 15 % (7/48). Long-term clinical success was 48 % (23/48). The estimated stent patency rate (95 % confidence interval) was 69 % (52-79) at 1 month, 54 % (37-66) at 6 months and 50 % (33-62) at 12 months.
  
  
  CONCLUSIONS
  Palliative SEMS placement provides rapid relief of obstruction and avoids a stoma in most patients with acute colonic obstruction caused by incurable or inoperable colon cancer. However, these benefits should be weighed against mortality and morbidity related to SEMS placement.
authors.affiliation: Department of Gastroenterology & Hepatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands, m.w.vandenberg@amc.nl.
authors.forename: M W
authors.initials: MW
authors.lastname: van den Berg
authors.forename: M
authors.initials: M
authors.lastname: Ledeboer
authors.forename: M G W
authors.initials: MG
authors.lastname: Dijkgraaf
authors.forename: P
authors.initials: P
authors.lastname: Fockens
authors.forename: F
authors.initials: F
authors.lastname: ter Borg
authors.forename: J E
authors.initials: JE
authors.lastname: van Hooft
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003108:Colonic Diseases / Q000209:etiology / Q000601:surgery*; D003110:Colonic Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery*; D008297:Male; D010166:Palliative Care / Q000379:methods*; D018570:Risk Assessment; D015607:Stents / Q000009:adverse effects; D016896:Treatment Outcome