title: Radical scavenging and antimicrobial activities of Croton zehntneri, Pterodon emarginatus and Schinopsis brasiliensis essential oils and their major constituents: estragole, trans-anethole, β-caryophyllene and myrcene.
abstract: The essential oils (EOs) from the Brazilian species Croton zehntneri, Pterodon emarginatus and Schinopsis brasiliensis were examined for their chemical constituents, and antioxidant and antimicrobial activities. The composition of EOs was determined by using gas chromatography coupled with mass spectrometry analysis, while the antioxidant activity was evaluated through the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays. Furthermore, the antimicrobial activity was investigated against Escherichia coli and Pseudomonas aeruginosa (both Gram-negative), Staphylococcus aureus (Gram-positive) and Candida parapsilosis (fungus). The main components of C. zehntneri, P. emarginatus and S. brasiliensis were identified as estragole, trans-anethole, β-caryophyllene and myrcene. Among the EOs, P. emarginatus showed the highest antioxidant activity, with an IC50 of 7.36 mg/mL and a Trolox equivalent antioxidant capacity of 3748 μmol/g determined by DPPH and ORAC assays, respectively. All EOs showed low activities against the bacterial strains tested, whereas the C. zehntneri oil and its main constituent estragole exhibited an appreciable antifungal activity against C. parapsilosis.
authors.affiliation: a Department of Pharmaceutical and Pharmacological Sciences , University of Padova , Padova , Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Donati
authors.forename: Andrea
authors.initials: A
authors.lastname: Mondin
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Fabricio Mendes
authors.initials: FM
authors.lastname: Miranda
authors.forename: Baraquizio Braga
authors.initials: BB
authors.lastname: do Nascimento
authors.forename: Giulia
authors.initials: G
authors.lastname: Schirato
authors.forename: Paolo
authors.initials: P
authors.lastname: Pastore
authors.forename: Guglielmina
authors.initials: G
authors.lastname: Froldi
mesh_terms: D000080462:Acyclic Monoterpenes; D000475:Alkenes / Q000494:pharmacology; D000081248:Allylbenzene Derivatives; D027926:Anacardiaceae / Q000737:chemistry; D000840:Anisoles / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D029802:Croton / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D007887:Fabaceae / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012717:Sesquiterpenes / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000080462:Acyclic Monoterpenes; D000475:Alkenes; D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D016166:Free Radical Scavengers; D039821:Monoterpenes; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C509595:myrcene; C007633:estragole; C024714:caryophyllene; C006578:anethole
keywords: Brazilian plants; Candida parapsilosis; DPPH; ORAC; essential oils