title: Implementation of a risk assessment program in a breast-imaging community practice.
abstract: BACKGROUND
  To review the initial results of the implementation of a risk assessment program in our outpatient community-based breast-imaging practice.
  
  
  METHODS
  From May 1, 2011 through November 4, 2013 a total of 96,389 patients presented to our facility. Each patient was required to complete a health history form. 24,850 (25.7 %) were flagged through our radiology information system (RIS) as potentially being at increased risk for breast cancer per responses on the health history form. Patient flagging was based on a system we developed. Letters were generated informing flagged patients and her physician that the patient could be a candidate for further breast cancer risk assessment. Genetic testing performed was primarily for BRCA1/BRCA2; testing for other mutations was offered based on personal and family history of the patient.
  
  
  RESULTS
  1,088 genetic counseling appointments occurred during the time frame from the 24,850 patients flagged, leading to 887 genetic tests performed. Forty-three mutations were detected: 21 BRCA1, 19 BRCA2, 1 MLH1, 1 MSH6 and 1 CHEK2. There were 717 negative tests, 20 variants of unknown significance; the remaining cases were cancelled. 464 high-risk MRIs were performed after the patient was referred from the program, from which 52 biopsies were performed due to a finding on MRI revealing 14 malignancies.
  
  
  CONCLUSIONS
  In our experience after implementation of a risk assessment program, 24,850 potential at-risk patients have been flagged, revealing 40 BRCA 1 or 2 mutations. Screening with breast MRI provided to at-risk patients revealed 14 cancers diagnosed that may have otherwise been undetected.
authors.affiliation: Elizabeth Wende Breast Care, LLC., 170 Sawgrass Dr., Rochester, NY, 14620, USA. sdestounis@ewbc.com.
authors.forename: Stamatia
authors.initials: S
authors.lastname: Destounis
authors.affiliation: Elizabeth Wende Breast Care, LLC., 170 Sawgrass Dr., Rochester, NY, 14620, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Arieno
authors.affiliation: Elizabeth Wende Breast Care, LLC., 170 Sawgrass Dr., Rochester, NY, 14620, USA.
authors.forename: Renee
authors.initials: R
authors.lastname: Morgan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology*; D003151:Community Health Centers; D005260:Female; D005500:Follow-Up Studies; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods; D006284:Health Plan Implementation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human
keywords: BRCA; Breast cancer; Breast imaging; Genetic counseling; Genetic testing