title: Abnormal liver function in different patients with Schistosoma japonicum.
abstract: Schistosomiasis japonica, caused by Schistosoma japonicum, is still a serious public health problem in China. It is important for schistosomiasis control to prevent from infection and advanced patients. Recent years, however, the form of the prevalence of schistosomiasis japonica in China was changed these days. Paying attention to the quality of life of these patients already infected with S. japonicum becomes a new objective to schistosomiasis control program. Although most of the chronic infections with S. japonicum will finally appear as liver fibrosis symptoms, it is still unknown liver function abnormalities in patients with severe forms of schistosomiasis, and there is also no evidence whether S. japonicum infection will directly cause damage to liver cells. Thus, this study investigated 494 patients diagnosed with S. japonicum (87.7%) and 69 healthy subjects from a endemic areas belonging to Jiangxi Province of China and aimed to evaluate the liver function abnormalities in patients with severe forms of schistosomiasis and possible associations with coinfection with HBV. The results showed that the hepatic metabolism situation significantly changed in patients infected with S. japonicum; meanwhile, the abnormal rates of ALT and AST in patients with schistosomiasis were significantly higher than that in the control group, which confirmed that patients infected with S. japonicum not only had damaged liver function but also the hepatic cells were directly influenced. And the coinfection of CHB and schistosomiasis japonica can be a risk factor for more serious outcomes in patients from endemic areas. These results give us the advice that in the further treatment of patients infected with S. japonicum, especially these coinfections, we should better give the routine liver-protection treatment in advance.
authors.affiliation: Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, China.
authors.forename: An
authors.initials: A
authors.lastname: Ning
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Wu
authors.forename: Hongyu
authors.initials: H
authors.lastname: Li
authors.forename: Jinyi
authors.initials: J
authors.lastname: Liang
authors.forename: Zulu
authors.initials: Z
authors.lastname: Gao
authors.forename: Jia
authors.initials: J
authors.lastname: Shen
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Fei
authors.initials: F
authors.lastname: Hu
authors.forename: Feng
authors.initials: F
authors.lastname: Wu
authors.forename: Pengyu
authors.initials: P
authors.lastname: Ji
authors.forename: Zhongdao
authors.initials: Z
authors.lastname: Wu
authors.forename: Xi
authors.initials: X
authors.lastname: Sun
mesh_terms: D000818:Animals; D002681:China / Q000453:epidemiology; D060085:Coinfection; D005260:Female; D006515:Hepatitis B virus / Q000502:physiology*; D022781:Hepatocytes; D006801:Humans; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000150:complications*; D008111:Liver Function Tests; D008297:Male; D011788:Quality of Life; D012549:Schistosoma japonicum / Q000502:physiology*; D012554:Schistosomiasis japonica / Q000150:complications*