title: Amplification of the immune response by agonistic antibodies.
abstract: During the last seven years, more than 1000 munine monoclonal antibodies (mAb) have been made which react with human leucocyte differentiation antigens. International workshops have extensively evaluated these mAb; over 25 differentiation antigens have been identified and included in an international WHO-approved nomenclature(1-3), called clusters of differentiation (CD). These are identified by both serological and biochemical analyses. In this article Ed Clark and Jeff Ledbetter summarize a subset of these mAb specific for differentiation antigens that, as agonists, induce activation, growth, or differentiation of lymphocytes.
authors.affiliation: Department of Microbiology and Immunology, University of Washington, SC-42, Seattle, WA 98195 USA; Oncogen Corporation, Seattle, WA 98121, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Clark
authors.affiliation: Department of Microbiology and Immunology, University of Washington, SC-42, Seattle, WA 98195 USA; Oncogen Corporation, Seattle, WA 98121, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Ledbetter