title: Single bone metastasis from adenocarcinoma of the lacrimal gland: a case report.
abstract: Malignant tumors of the lacrimal gland are rare, and single bone metastases from lacrimal gland carcinoma are an exceptional event. We present the case of a 71-year-old man with a history of lumbar pain and left exophthalmos. Surgical resection of the lacrimal lesion and a bone biopsy gave a final histopathological diagnosis of primary ductal adenocarcinoma of the lacrimal gland with bone metastasis. The pathological tissue from both procedures was positive for androgen receptor expression. The patient underwent embolization and radiotherapy in association with total androgen blockade. After 20 months, the patient is still asymptomatic and has maintained the partial response at L1 with no progression to other sites. Our patient would appear to have a better prognosis and the disease a more indolent clinical course than the other cases of ductal adenocarcinoma of the lacrimal gland reported in the literature.
authors.affiliation: Osteoncology & Rare Tumors Center, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy.
authors.forename: Marianna
authors.initials: M
authors.lastname: Ricci
authors.forename: Elena
authors.initials: E
authors.lastname: Amadori
authors.forename: Fausto
authors.initials: F
authors.lastname: Chiesa
authors.forename: Alberto
authors.initials: A
authors.lastname: Bongiovanni
authors.forename: Chiara
authors.initials: C
authors.lastname: Liverani
authors.forename: Laura
authors.initials: L
authors.lastname: Fabbri
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Falasconi
authors.forename: Roberto
authors.initials: R
authors.lastname: Casadei
authors.forename: Devil
authors.initials: D
authors.lastname: Oboldi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Galassi
authors.forename: Simona
authors.initials: S
authors.lastname: Micheletti
authors.forename: Stefano
authors.initials: S
authors.lastname: Severi
authors.forename: Luigi
authors.initials: L
authors.lastname: Serra
authors.forename: Federica
authors.initials: F
authors.lastname: Pieri
authors.forename: Luca
authors.initials: L
authors.lastname: Calabrese
authors.forename: Nada
authors.initials: N
authors.lastname: Riva
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Calpona
authors.forename: Erica
authors.initials: E
authors.lastname: Gunelli
authors.forename: Laura
authors.initials: L
authors.lastname: Mercatali
authors.forename: Dino
authors.initials: D
authors.lastname: Amadori
authors.forename: Toni
authors.initials: T
authors.lastname: Ibrahim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy / Q000556:secondary*; D005134:Eye Neoplasms / Q000473:pathology*; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology*; D008159:Lumbar Vertebrae / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: androgen receptor; androgen receptor blockade; bone metastasis; ductal adenocarcinoma; lacrimal gland tumor