title: Strategies for delivering porphyrinoid-based photosensitizers in therapeutic applications.
abstract: Delivery strategies for porphyrinoid-based photosensitizers for use in therapeutic applications are based on a myriad of factors, which include porphyrinoid structure, solubility and cellular targets. These drug-delivery methods include encapsulation, hydrogels, protein carriers, nanoparticles and polymeric micelles among others. This article reviews the strategies for delivering porphyrinoids published to date and will focus on porphyrins, corroles, chlorins, bacteriochlorins, porphyrazines and phthalocyanines. Highlighted are the most recent and different strategies used for each of the corresponding porphyrinoid-based macrocycles.
authors.affiliation: Department of Chemistry, New York City College of Technology, 300 Jay Street, Brooklyn, NY 11201, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Samaroo
authors.forename: Evelyn
authors.initials: E
authors.lastname: Perez
authors.forename: Amit
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Andrew
authors.initials: A
authors.lastname: Wills
authors.forename: Naphtali
authors.initials: N
authors.lastname: O'Connor
mesh_terms: D016503:Drug Delivery Systems; D007211:Indoles / Q000008:administration & dosage; D054833:Isoindoles; D008823:Micelles; D053758:Nanoparticles; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011166:Porphyrins / Q000008:administration & dosage*
chemical_list: D007211:Indoles; D054833:Isoindoles; D008823:Micelles; D017319:Photosensitizing Agents; D011166:Porphyrins; C452433:bacteriochlorin; C431863:corrole; C013647:phthalocyanine