title: Subcallosal artery stroke: infarction of the fornix and the genu of the corpus callosum. The importance of the anterior communicating artery complex. Case series and review of the literature.
abstract: BACKGROUND
  Despite the variable anatomy of the anterior communicating artery (AcoA) complex, three main perforating branches can be typically identified the largest of which being the subcallosal artery (ScA). We present a case series of infarction in the vascular territory of the ScA to highlight the anatomy, the clinical symptomatology, and the presumed pathophysiology as it pertains to endovascular and surgical management of vascular pathology in this region.
  
  
  METHODS
  In this retrospective multicenter case series study of patients who were diagnosed with symptomatic ScA stroke, we analyzed all available clinical records, MRI, and angiographic details. Additionally, a review of the literature is provided.
  
  
  RESULTS
  We identified five different cases of ScA stroke, leading to a subsequent infarction of the fornix and the genu of the corpus callosum. The presumed pathophysiology in non-iatrogenic cases is microangiopathy, rather than embolic events; iatrogenic SCA occlusion can present after both surgical and endovascular treatment of AcoA aneurysms that may occur with or without occlusion of the AcoA.
  
  
  CONCLUSIONS
  Stroke in the vascular territory of the ScA leads to a characteristic imaging and clinical pattern. Ischemia involves the anterior columns of the fornix and the genu of the corpus callosum, and patients present with a Korsakoff's syndrome including disturbances of short-term memory and cognitive changes. We conclude that despite its small size, the ScA is an important artery to watch out for during surgical or endovascular treatment of AcoA aneurysms.
authors.affiliation: Department of Radiology and Neuroradiology, Klinikum Duisburg - Sana Kliniken, Zu den Rehwiesen 9, D-47055, Duisburg, Germany, dmeila@yahoo.de.
authors.forename: Dan
authors.initials: D
authors.lastname: Meila
authors.forename: Guillaume
authors.initials: G
authors.lastname: Saliou
authors.forename: Timo
authors.initials: T
authors.lastname: Krings
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D003337:Corpus Callosum / Q000098:blood supply* / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D020712:Fornix, Brain / Q000098:blood supply / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional; D002532:Intracranial Aneurysm / Q000175:diagnosis* / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000175:diagnosis* / Q000473:pathology