title: Islet autotransplantation and total pancreatectomy.
abstract: The goal of IAT is the preservation of beta-cell mass at the time of pancreatectomy. The majority of recipients have significant endogenous beta-cell function with positive blood C-peptide after surgery, even if only approximately one third achieve insulin independence. In appropriately selected patients, total pancreatectomy combined with IAT achieves relief of pain and improves quality of life with relatively easier-to-manage glycemic control and avoidance of hyper- and hypoglycemic episodes. Current research is focused on improving techniques of islet isolation and engraftment as well as long-term survival of autografted islets.
authors.forename: Piotr
authors.initials: P
authors.lastname: Witkowski
authors.forename: Omid
authors.initials: O
authors.lastname: Savari
authors.forename: Jeffrey B
authors.initials: JB
authors.lastname: Matthews
mesh_terms: D015746:Abdominal Pain / Q000517:prevention & control; D000208:Acute Disease; D001786:Blood Glucose / Q000378:metabolism; D000075202:Contraindications; D020249:Hormone Replacement Therapy; D006801:Humans; D016381:Islets of Langerhans Transplantation; D010180:Pancreatectomy / Q000379:methods*; D010187:Pancreatic Hormones / Q000627:therapeutic use; D050500:Pancreatitis, Chronic / Q000097:blood / Q000178:diet therapy / Q000601:surgery*; D018579:Patient Selection; D011788:Quality of Life; D012008:Recurrence; D014182:Transplantation, Autologous
chemical_list: D001786:Blood Glucose; D010187:Pancreatic Hormones