title: Eyelid tremor in a patient with anti-caspr2 antibody-related encephalitis.
abstract: We describe the first case of a patient with eyelid tremor probably associated with anti-contactin-associated protein-like 2 (Caspr2) antibody. Encephalitis associated with anti-voltage-gated potassium channel antibody is now attributed to autoantibodies against leucine-rich glioma inactivated 1 (Lgi1) and less frequently against Caspr2. Eyelid tremor or blepharoclonus is a rare or underdiagnosed involuntary movement that has been found in patients with infarction in the thalamus or drug-induced or idiopathic parkinsonism. Since patients with anti-Caspr2 antibody-related encephalitis occasionally have extrapyramidal signs, we speculate that the eyelid tremor was also caused by anti-Caspr2 antibody in our patient. Partial resolution of his symptoms by plasmapheresis also supported the involvement in immunological processes.
authors.affiliation: Department of Neurology, Sakai Hospital, Osaka, Japan ; Department of Neurology, Kinki University Faculty of Medicine, Osaka, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ueno
authors.affiliation: Department of Neurology, Sakai Hospital, Osaka, Japan ; Department of Neurology, Kinki University Faculty of Medicine, Osaka, Japan.
authors.forename: Makito
authors.initials: M
authors.lastname: Hirano
authors.affiliation: Department of Neurology, Sakai Hospital, Osaka, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sakamoto
authors.affiliation: Department of Neurology, Kinki University Faculty of Medicine, Osaka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Kusunoki
authors.affiliation: Department of Neurology, Sakai Hospital, Osaka, Japan.
authors.forename: Yusaku
authors.initials: Y
authors.lastname: Nakamura
keywords: Anti-Caspr2 antibody-related encephalitis; Blepharoclonus; Eyelid tremor