title: Quantitative assessment of synovitis in Legg-Calvé-Perthes disease using gadolinium-enhanced MRI.
abstract: A quantitative method to assess hip synovitis in Legg-Calvé-Perthes disease (LCPD) is not currently available. To develop this method, the areas of synovial enhancement on gadolinium-enhanced MRI (Gd-MRI) were measured by two independent observers. The volume of synovial enhancement was significantly increased in the initial and the fragmentation stages of LCPD (Waldenström stages I and II), with a persistence of synovitis into the reossification stage (stage III). The Gd-MRI method had high interobserver and intraobserver agreements and may serve as a useful method to monitor the effect of various treatments on hip synovitis in LCPD.
authors.affiliation: aCenter of Excellence in Hip Disorders, Texas Scottish Rite Hospital for Children bUniversity of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Neal
authors.forename: Jack C
authors.initials: JC
authors.lastname: O'Brien
authors.forename: Jamie
authors.initials: J
authors.lastname: Burgess
authors.forename: Chanhee
authors.initials: C
authors.lastname: Jo
authors.forename: Harry K W
authors.initials: HK
authors.lastname: Kim
mesh_terms: D002648:Child; D002675:Child, Preschool; D003287:Contrast Media; D005260:Female; D005270:Femur Head / Q000473:pathology*; D005682:Gadolinium; D006621:Hip Joint / Q000473:pathology; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015588:Observer Variation; D011446:Prospective Studies; D011859:Radiography; D013585:Synovitis / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; D005682:Gadolinium