title: Marine n-3 Fatty Acids and Gene Expression in Peripheral Blood Mononuclear Cells.
abstract: Intake of marine n-3 fatty acids has been shown to have beneficial effects on cardiovascular disease. Gene expression analyses in peripheral blood mononuclear cells (PBMCs) are used to understand the underlying mechanisms of action of marine n-3 fatty acids. The aim of this review was to summarize the effects mediated by marine n-3 fatty acids on gene expression in PBMCs. A systematic literature search was conducted in PubMed in May 2014 and 14 papers were included. Targeted gene expression studies were reported in 9 papers and focused on genes involved in lipid metabolism and inflammation. Whole genome transcriptome analyses were conducted in 5 papers, and processes and pathways related to atherosclerotic plaque formation such as inflammation, oxidative stress response, cell cycle, cell adhesion, and apoptosis were modulated after fish oil supplementation. PBMC gene expression profiling has a potential to clarify further the molecular effects of fish oil consumption on human health.
authors.affiliation: Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences (HiOA), P.O. Box 4, St Olavs plass, 0130 Oslo, Norway.
authors.forename: Stine M
authors.initials: SM
authors.lastname: Ulven
authors.affiliation: Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences (HiOA), P.O. Box 4, St Olavs plass, 0130 Oslo, Norway.
authors.forename: Mari C
authors.initials: MC
authors.lastname: Myhrstad
authors.affiliation: Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, P.O. Box 1046, Blindern, 0317 Oslo, Norway.
authors.forename: Kirsten B
authors.initials: KB
authors.lastname: Holven
keywords: Cardiovascular disease; Dietary intervention study; Gene expression; Inflammation; Lipid metabolism; Marine n-3 fatty acids; PBMCs; Peripheral mononuclear cells; Transcriptomics