title: Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro.
abstract: The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability to induce dormancy in Plasmodium falciparum. There was no increase in the activity of artemisone entrapped in Pheroid vesicles against multidrug-resistant P. falciparum lines. Artemisone induced the formation of dormant ring stages similar to dihydroartemisinin. Thus, the Pheroid delivery system neither improved the activity of artemisone nor prevented the induction of dormant rings.
authors.affiliation: DST/NWU Preclinical Drug Development Platform, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
authors.forename: Lizette
authors.initials: L
authors.lastname: Grobler
authors.affiliation: Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia.
authors.forename: Marina
authors.initials: M
authors.lastname: Chavchich
authors.affiliation: Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.
authors.forename: Richard K
authors.initials: RK
authors.lastname: Haynes
authors.affiliation: Australian Army Malaria Institute, Enoggera, Brisbane, Queensland, Australia.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Edstein
authors.affiliation: DST/NWU Preclinical Drug Development Platform, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa anne.grobler@nwu.ac.za.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Grobler
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000737:chemistry; D037621:Artemisinins / Q000494:pharmacology*; D002478:Cells, Cultured; D004337:Drug Carriers; D004339:Drug Compounding; D004351:Drug Resistance; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D020128:Inhibitory Concentration 50; D008018:Life Cycle Stages / Q000187:drug effects* / Q000502:physiology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011092:Polyethylene Glycols / Q000737:chemistry; D012277:Ricinoleic Acids / Q000737:chemistry; D024502:alpha-Tocopherol / Q000737:chemistry
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004337:Drug Carriers; D012277:Ricinoleic Acids; D016718:Arachidonic Acid; D011092:Polyethylene Glycols; C039060:artenimol; C514498:artemisone; D024502:alpha-Tocopherol