title: Prostaglandin E2 inhibits IL-10 production by bovine CD4+ T cells.
abstract: Although prostaglandin E2 (PGE2) is a pro-inflammatory mediator, it also produces some effect which is anti-inflammatory in character. It is suggested that one of the mechanisms responsible for the latter effect is the increased synthesis of IL-10. The aim of this study has been to determine the influence of PGE2 on IL-10 production by bovine CD4+ and CD8+ T cells and NK cells. With this aim, peripheral blood mononuclear cells collected from 12-month-old heifers (n = 10) were treated without or with PGE2 (10(-6) M). Flow cytometric analysis showed that PGE2 caused a reduction in the percentage of IL-10 producing CD4+ T cells (P < 0.001), while leaving the secretion of this cytokine by CD8+ T cells and NK cells unaffected. This seems to indicate that PGE2 in cattle does not produce an anti-inflammatory effect by increasing the synthesis of IL-10; contrary to this, it may aggravate an inflammatory response by inhibiting the secretion of this cytokine by CD4+ T cells.
authors.forename: M
authors.initials: M
authors.lastname: Zuśka-Prot
authors.forename: T
authors.initials: T
authors.lastname: Maślanka
authors.forename: A
authors.initials: A
authors.lastname: Jasiecka
authors.forename: J J
authors.initials: JJ
authors.lastname: Jaroszewski
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D015232:Dinoprostone / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*
chemical_list: D016753:Interleukin-10; D015232:Dinoprostone