title: Turnover of strains and intraclonal variation amongst Pseudomonas aeruginosa isolates from paediatric CF patients.
abstract: Transmissible strains of Pseudomonas aeruginosa in cystic fibrosis (CF) have been well documented. Our longitudinal survey of P. aeruginosa isolates from 45 paediatric CF patients indicated strain persistence and intraclonal diversity, but not cross infection. This study demonstrates the need for regular P. aeruginosa strain surveillance using genotyping.
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Hall
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Fothergill
authors.affiliation: Alder Hey Children's Hospital, Liverpool, United Kingdom.
authors.forename: Paul S
authors.initials: PS
authors.lastname: McNamara
authors.affiliation: Alder Hey Children's Hospital, Liverpool, United Kingdom.
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Southern
authors.affiliation: Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom. Electronic address: C.Winstanley@liv.ac.uk.
authors.forename: Craig
authors.initials: C
authors.lastname: Winstanley
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000382:microbiology; D003550:Cystic Fibrosis / Q000382:microbiology*; D004739:England; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics* / Q000302:isolation & purification* / Q000472:pathogenicity
keywords: Cystic fibrosis; Genotyping; Pseudomonas aeruginosa