title: Bone scan alterations in aromatase inhibitor-treated patients.
abstract: We report bone scan changes in 3 patients receiving aromatase inhibitors as adjuvant treatment for postmenopausal hormone receptor-positive breast cancer. Compared with bone scans before treatment, repeated scans after at least 10 months of aromatase inhibitor treatment showed increased activity in the peripheral skeleton and the skull. In 2 patients, these alterations could be correlated with increased markers of bone turnover. They probably result from high bone turnover induced by estrogen depletion caused by aromatase inhibitors. This effect should be taken into account in the differential diagnosis of a bone scan pattern suggestive of hyperparathyroidism, which was ruled out.
authors.affiliation: From the Departments of *Nuclear Medicine, †Internal Medicine, Endocrinology, ‡Medical Oncology, and §Laboratory Medicine, Algemeen Ziekenhuis Sint-Jan Brugge-Oostende, Brugge, Belgium.
authors.forename: Frank
authors.initials: F
authors.lastname: De Geeter
authors.forename: Annick
authors.initials: A
authors.lastname: Van den Bruel
authors.forename: Eveline
authors.initials: E
authors.lastname: De Cuypere
authors.forename: Michel
authors.initials: M
authors.lastname: Langlois
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors