title: Primary transpupillary thermotherapy for choroidal indeterminate melanocytic lesions.
abstract: OBJECTIVE
  This study aimed to assess the ocular and metastatic outcomes of patients with choroidal indeterminate melanocytic lesions treated by primary transpupillary thermotherapy (TTT).
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  Eight patients presenting choroidal indeterminate melanocytic lesions treated by primary TTT.
  
  
  METHODS
  A retrospective chart review was conducted for patients with a newly diagnosed choroidal indeterminate melanocytic lesion treated by at least 3 TTT sessions from 2002 to 2011. Best-corrected visual acuity and lesion dimensions were measured at baseline and during follow-up. Complications were recorded including lesion growth, metastasis, melanoma-related mortality, and treatment-related complications.
  
  
  RESULTS
  Mean initial thickness was 2.0 ± 0.8 mm. Patients had an average of 3.0 ± 0.9 risk factors for lesion growing. Three patients (38%) had lesion growth. Two patients (25%) had severe visual loss (>1.0 logMAR) directly related to TTT treatment. There were no fatalities due to metastasis.
  
  
  CONCLUSIONS
  Despite careful patient selection and systematic treatment with at least 3 TTT sessions, the use of primary TTT to treat patients with choroidal indeterminate melanocytic lesions with ≥ 1 risk factor for lesion growth yielded poor local lesion control and the possibility for severe ocular complications.
authors.affiliation: Centre Universitaire d'Ophtalmologie, CHU de Québec, Hôpital du Saint-Sacrement, Quebec City; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Quebec City.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Turcotte
authors.affiliation: Centre Universitaire d'Ophtalmologie, CHU de Québec, Hôpital du Saint-Sacrement, Quebec City; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Quebec City.
authors.forename: Dan
authors.initials: D
authors.lastname: Bergeron
authors.affiliation: Centre Universitaire d'Ophtalmologie, CHU de Québec, Hôpital du Saint-Sacrement, Quebec City; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Quebec City.
authors.forename: Alain P
authors.initials: AP
authors.lastname: Rousseau
authors.affiliation: Centre Universitaire d'Ophtalmologie, CHU de Québec, Hôpital du Saint-Sacrement, Quebec City; Département d'Ophtalmologie, Faculté de Médecine, Université Laval, Quebec City; Département d'Ophtalmologie, CHU Rennes, France; Université de Rennes 1, Faculté de Médecine, France. Electronic address: frederic.mouriaux@chu-rennes.fr.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mouriaux
mesh_terms: D000328:Adult; D000368:Aged; D002830:Choroid Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011680:Pupil; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology