title: Photocatalytic degradation of rosuvastatin: analytical studies and toxicity evaluations.
abstract: Photocatalytic degradation of rosuvastatin, which is a drug that has been used to reduce blood cholesterol levels, was studied in this work employing ZnO as catalyst. The experiments were carried out in a temperature-controlled batch reactor that was irradiated with UV light. Preliminary the effects of the photocatalyst loading, the initial pH and the initial rosuvastatin concentration were evaluated. The experimental results showed that rosuvastatin degradation is primarily a photocatalytic process, with pseudo-first order kinetics. The byproducts that were generated during the oxidative process were identified using nano-ultra performance liquid chromatography tandem mass spectrometry (nano-UPLC-MS/MS) and acute toxicity tests using Daphnia magna were done to evaluate the toxicity of the untreated rosuvastatin solution and the reactor effluent.
authors.affiliation: Chemical Engineering Department, Federal University of Rio Grande do Sul, Rua Engenheiro Luiz Englert s/n, CEP: 90040-040 Porto Alegre, RS, Brazil. Electronic address: tiele@enq.ufrgs.br.
authors.forename: Tiele Caprioli
authors.initials: TC
authors.lastname: Machado
authors.affiliation: Chemical Institute, Federal University of Rio Grande do Sul, Avenida Bento Gonçalves, 9500, CEP: 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Tânia Mara
authors.initials: TM
authors.lastname: Pizzolato
authors.affiliation: Ecology Center, Federal University of Rio Grande do Sul, Avenida Bento Gonçalves, 9500, CEP: 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Arenzon
authors.affiliation: Biotechnology Center, Federal University of Rio Grande do Sul, Avenida Bento Gonçalves, 9500, CEP: 91501-970 Porto Alegre, RS, Brazil.
authors.forename: Jeferson
authors.initials: J
authors.lastname: Segalin
authors.affiliation: Chemical Engineering Department, Federal University of Rio Grande do Sul, Rua Engenheiro Luiz Englert s/n, CEP: 90040-040 Porto Alegre, RS, Brazil.
authors.forename: Marla Azário
authors.initials: MA
authors.lastname: Lansarin
mesh_terms: D000818:Animals; D003621:Daphnia; D005464:Fluorobenzenes / Q000737:chemistry* / Q000633:toxicity; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000737:chemistry* / Q000633:toxicity; D007700:Kinetics; D010782:Photolysis; D011743:Pyrimidines / Q000737:chemistry* / Q000633:toxicity; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000737:chemistry* / Q000633:toxicity; D023382:Toxicity Tests, Acute; D014466:Ultraviolet Rays; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000633:toxicity
chemical_list: D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D014874:Water Pollutants, Chemical; D000068718:Rosuvastatin Calcium
keywords: Byproducts; Photocatalysis; Rosuvastatin; Toxicity