title: Enrollment of research subjects through telemedicine networks in a multicenter acute intracerebral hemorrhage clinical trial: design and methods.
abstract: BACKGROUND
  Enrollment of subjects in acute stroke trials is often hindered by narrow timeframes, because a large proportion of patients arrive via transfers from outside facilities rather than primary arrival at the enrolling hospital.
  
  
  BACKGROUND
  Telemedicine networks have been increasingly used for provision of care for acute stroke patients at facilities outside of major academic centers. Treatment decisions made through telemedicine networks in patients with acute ischemic stroke have been shown to be safe, reliable, and effective. With the expanding use of this technology and the impediments to enrolling subjects into clinical trials, this approach can be applied successfully to the field of clinical research.
  
  
  CONCLUSIONS
  The Antihypertensive Treatment of Acute Cerebral Hemorrhage II trial is a phase III randomized multicenter trial that has developed a protocol in collaboration with participating sites to implement the use of telemedicine networks for the enrollment of research subjects. The protocol describes the operating procedures and legal and Institutional Review Board perspectives for its implementation.
authors.affiliation: Zeenat Qureshi Stroke Institute, St Cloud MN, USA.
authors.forename: J
authors.initials: J
authors.lastname: Alfredo Caceres
authors.affiliation: Yale University School of Medicine, Department of Neurology, New Haven, CT, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Greer
authors.affiliation: Harvard Medical School, Center for Neurologic Emergencies, Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Goldstein
authors.affiliation: Harvard Medical School, Telestroke Services, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Viswanathan
authors.affiliation: Section of Vascular Neurology and Neurocritical Care, Baylor College of Medicine, Houston, TX, USA.
authors.forename: Jose I
authors.initials: JI
authors.lastname: Suarez
authors.affiliation: Zeenat Qureshi Stroke Institute, St Cloud MN, USA.
authors.forename: Logan
authors.initials: L
authors.lastname: Brau
authors.affiliation: Penn State Hershey Neurosurgery, Hershey, PA, USA.
authors.forename: Joseph Christopher
authors.initials: JC
authors.lastname: Zacko
authors.affiliation: Oregon Health and Science University, Department of Neurology, Providence Stroke Center, Portland, OR, USA.
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Lowenkopf
authors.affiliation: Wexner Medical Center, The Ohio State University, Columbus, OH, USA.
authors.forename: Chad M
authors.initials: CM
authors.lastname: Miller
authors.affiliation: Neurointerventional and Neurocritical Care Services, Neurosciences Institute, Abington Memorial Hospital, Abington, PA, USA.
authors.forename: Qaisar A
authors.initials: QA
authors.lastname: Shah
authors.affiliation: Acute Neurological Services, Swedish Medical Center, Englewood, CO, USA.
authors.forename: Ira
authors.initials: I
authors.lastname: Chang
authors.affiliation: Department of Neurology, University of South Carolina School of Medicine, Columbia, SC, USA.
authors.forename: Souvik
authors.initials: S
authors.lastname: Sen
authors.affiliation: Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Messe
authors.affiliation: Harvard Medical School, Boston, MA, USA.
authors.forename: Sherry H
authors.initials: SH
authors.lastname: Chou
authors.affiliation: Zeenat Qureshi Stroke Institute, St Cloud MN, USA ; Zeenat Qureshi Stroke Institute, St Cloud, MN, USA.
authors.forename: Adnan I
authors.initials: AI
authors.lastname: Qureshi