title: [Substances from pyrolised tissues of reptile carcases differently modulate immunity of mammals of both sexes].
abstract: Substances with gender action on immunity were detected in water soluble hydrolised matter from reptile carcases. The gender action was shown on isolated blood neutrophils, whole blood and in vivo by the antiviral activity on experimental animals, contaminated with three types of viruses: Herpes simplex type 1, the virus of encephalomyocarditis and the virus of hepatitis of mice. The possible mechanism of the inhibitory action on the male immunity was associated with the protein kinase cascade, including protein kinase C, activated by phorbolmyristate in the cells of the immune system.
authors.forename: D G
authors.initials: DG
authors.lastname: Mal'dov
authors.forename: A P
authors.initials: AP
authors.lastname: Bel'kov
authors.forename: A V
authors.initials: AV
authors.lastname: Il'ichev
authors.forename: E I
authors.initials: EI
authors.lastname: Astashkin
authors.forename: S S
authors.initials: SS
authors.lastname: Grigorian
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
mesh_terms: D000818:Animals; D018188:Cardiovirus Infections / Q000188:drug therapy / Q000821:virology; D045424:Complex Mixtures / Q000302:isolation & purification / Q000494:pharmacology*; D018352:Coronavirus Infections / Q000188:drug therapy / Q000821:virology; D004686:Encephalomyocarditis virus / Q000187:drug effects / Q000502:physiology; D005260:Female; D006524:Hepatitis, Viral, Animal / Q000188:drug therapy / Q000821:virology; D006561:Herpes Simplex / Q000188:drug therapy / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D008297:Male; D051379:Mice; D006517:Murine hepatitis virus / Q000187:drug effects / Q000502:physiology; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012104:Reptiles / Q000378:metabolism; D012737:Sex Factors; D019562:Viral Load / Q000187:drug effects*
chemical_list: D045424:Complex Mixtures; D019255:NADPH Oxidases; D011493:Protein Kinase C