title: 2,6-Bis(2,6-diethylphenyliminomethyl)pyridine coordination compounds with cobalt(II), nickel(II), copper(II), and zinc(II): synthesis, spectroscopic characterization, X-ray study and in vitro cytotoxicity.
abstract: Coordination compounds with cobalt(II), nickel(II), copper(II) and zinc(II) and the ligand 2,6-bis(2,6-diethylphenyliminomethyl)pyridine (L) were synthesized and fully characterized by IR and UV-Vis-NIR spectroscopy, elemental analysis, magnetic susceptibility and X-ray diffraction for two representative cases. These novel compounds were designed to study their activity as anti-proliferative drugs against different human cancer cell lines. The tridentate ligand forms heptacoordinated compounds from nitrate metallic salts, where the nitrate acts in a chelating form to complete the seven coordination positions. In vitro cell growth inhibition was measured for Co(II), Cu(II) and Zn(II) complexes, as well as for the free ligand. Upon coordination, the IC50 value of the transition-metal compounds is improved compared to the free ligand. The copper(II) and zinc(II) compounds are the most promising candidates for further in vitro and in vivo studies. The activity against colon and prostate cell lines merits further research, in views of the limited therapeutic options for such cancer types.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico.
authors.forename: Pablo
authors.initials: P
authors.lastname: Martinez-Bulit
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico.
authors.forename: Ariadna
authors.initials: A
authors.lastname: Garza-Ortíz
authors.affiliation: Departamento de Química, CINVESTAV, AP 14-740, México D.F. 07000, Mexico.
authors.forename: Edgar
authors.initials: E
authors.lastname: Mijangos
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico; Unidad de Experimentación Animal, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico.
authors.forename: Lidia
authors.initials: L
authors.lastname: Barrón-Sosa
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico; Unidad de Experimentación Animal, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico.
authors.forename: Francisco
authors.initials: F
authors.lastname: Sánchez-Bartéz
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico; Unidad de Experimentación Animal, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico.
authors.forename: Isabel
authors.initials: I
authors.lastname: Gracia-Mora
authors.affiliation: Departamento de Química, CINVESTAV, AP 14-740, México D.F. 07000, Mexico.
authors.forename: Angelina
authors.initials: A
authors.lastname: Flores-Parra
authors.affiliation: Departamento de Química, CINVESTAV, AP 14-740, México D.F. 07000, Mexico.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Contreras
authors.affiliation: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands; Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
authors.forename: Jan
authors.initials: J
authors.lastname: Reedijk
authors.affiliation: Departamento de Química Inorgánica, Facultad de Química, Universidad Nacional Autónoma de México, C.U., Coyoacán, México D.F. 04510, Mexico. Electronic address: norah@unam.mx.
authors.forename: Norah
authors.initials: N
authors.lastname: Barba-Behrens
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity*; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D011725:Pyridines; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc
keywords: 2,6-bis(arylimino)pyridine derivatives; Cobalt(II); Copper(II); Cytotoxicity; Heptacoordinated compounds; Zinc(II)