title: Effect of intracycle motion correction algorithm on image quality and diagnostic performance of computed tomography coronary angiography in patients with suspected coronary artery disease.
abstract: OBJECTIVE
  We sought to explore the impact of intracycle motion correction algorithms (MCA) in the interpretability and diagnostic accuracy of computed tomography coronary angiography (CTCA) performed in patients suspected of coronary artery disease (CAD) referred to invasive coronary angiography.
  
  
  METHODS
  Patients with suspected CAD referred to invasive coronary angiography previously underwent CTCA. Patients under rate-control medications were advised to withhold for the previous 24 hours. The primary end point of the study was to evaluate image interpretability and diagnostic performance of MCA compared to conventional reconstructions in patients referred to invasive angiography because of suspected CAD.
  
  
  RESULTS
  Thirty-five patients were prospectively included in the study protocol. The mean age was 61.4 ± 9.4 years. Twenty-seven (77%) patients were men. A total of 533 coronary segments were evaluated using conventional and MCA reconstructions. MCA reconstructions were associated to higher interpretability rates (525 of 533, 98.5% vs. 515 of 533, 96.6 %; P < .001) and image quality scores (3.88 ± 0.54 vs. 3.78 ± 0.76; P < .0001) compared to conventional reconstructions. Although only mild, a significant difference was observed regarding the diagnostic performance between reconstruction modes, with an area under the curve of 0.90 (0.87-0.92) versus 0.89 (0.86-0.92), respectively, for MCA and conventional reconstructions (P = .0447).
  
  
  CONCLUSIONS
  In this pilot investigation, MCA reconstructions performed in patients with suspected CAD were associated to higher interpretability rates and image quality scores compared to conventional reconstructions, although only mild differences were observed regarding the diagnostic performance between reconstruction modes.
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina. Electronic address: investigacion@diagnosticomaipu.com.ar.
authors.forename: Patricia
authors.initials: P
authors.lastname: Carrascosa
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Deviggiano
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Capunay
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina.
authors.forename: Macarena C
authors.initials: MC
authors.lastname: De Zan
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Goldsmit
authors.affiliation: Department of Cardiovascular Imaging, Diagnóstico Maipú, Av Maipú 1668, Vicente López, B1602ABQ Buenos Aires, Argentina; Department of Interventional Cardiology, Sanatorio Guemes, Buenos Aires, Argentina.
authors.forename: Gaston A
authors.initials: GA
authors.lastname: Rodriguez-Granillo
mesh_terms: D000465:Algorithms; D016477:Artifacts; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009038:Motion; D010865:Pilot Projects; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*
keywords: Imaging; interpretability; multidetector; β-blockers