title: β-Cyclodextrin-grafted on multiwalled carbon nanotubes as versatile nanoplatform for entrapment of guanine-based drugs.
abstract: The design of β-cyclodextrin/multiwalled carbon nanotubes hybrid (β-CD-MWCNT) as nanoplatform for the entrapment and delivery of guanine based drugs is described here. The functionalized carbon nanomaterials have been characterized by XPS spectroscopy, electron microscopy (FEG-SEM and TEM), AFM, TGA, and FT-IR to achieve insights on structure, morphology and chemical composition. The drug binding abilities of nanocarrier towards the guanine (G) and Acyclovir (Acy) were proved by UV-vis and DSC experiments. Host-guest equilibrium association constants and drug loading have been evaluated for G/β-CD-MWCNT and Acy/β-CD-MWCNT complexes. The release studies showed a sustained delivery of Acy without initial burst effect confirming a strong interaction of drug with the nanoplatform sites. The preliminary antiviral data indicated that the Acyclovir loaded into the β-CD-MWCNT platform interferes with HSV-1 replication and the antireplicative effect was higher than the free drug.
authors.affiliation: Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, Università di Messina, C.da di Dio, 98166 Messina, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Iannazzo
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-ISMN c/o Dip. di Scienze Chimiche dell'Università di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy. Electronic address: antonino.mazzaglia@ismn.cnr.it.
authors.forename: Antonino
authors.initials: A
authors.lastname: Mazzaglia
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-ISMN c/o Dip. di Scienze Chimiche dell'Università di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Scala
authors.affiliation: Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, Università di Messina, C.da di Dio, 98166 Messina, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pistone
authors.affiliation: Dipartimento di Ingegneria Elettronica, Chimica e Ingegneria Industriale, Università di Messina, C.da di Dio, 98166 Messina, Italy.
authors.forename: Signorino
authors.initials: S
authors.lastname: Galvagno
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-IPCF, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Lanza
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-ISMN, UOS Montelibretti, Via Salaria, 00015 Monterotondo Stazione, Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Riccucci
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-ISMN, UOS Montelibretti, Via Salaria, 00015 Monterotondo Stazione, Rome, Italy.
authors.forename: Gabriel Maria
authors.initials: GM
authors.lastname: Ingo
authors.affiliation: Dipartimento di Scienze Biologiche e Ambientali, Università di Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
authors.forename: Ivana
authors.initials: I
authors.lastname: Colao
authors.affiliation: Dipartimento di Scienze Biologiche e Ambientali, Università di Messina, Viale Ferdinando Stagno D'Alcontres, 98166 Messina, Italy.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Sciortino
authors.affiliation: Consiglio Nazionale delle Ricerche CNR-ISMN, Via Piero Gobetti 101, 40129 Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Valle
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy. Electronic address: apiperno@unime.it.
authors.forename: Anna
authors.initials: A
authors.lastname: Piperno
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grassi
mesh_terms: D000212:Acyclovir / Q000737:chemistry; D057930:Click Chemistry / Q000379:methods; D006147:Guanine / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D037742:Nanotubes, Carbon; D047392:beta-Cyclodextrins; D006147:Guanine; C031215:betadex; D000212:Acyclovir
keywords: Acyclovir; Click chemistry; Guanine; Multiwalled carbon nanotubes; β-Cyclodextrins