title: The effects of carvedilol and nebivolol on oxidative stress status in patients with non-ischaemic heart failure.
abstract: BACKGROUND
  Carvedilol and nebivolol have favourable properties such as anti-oxidative effects in addition to other beta-blockers. However, which of these drugs is more effective on oxidative stress is unclear.
  
  
  OBJECTIVE
  To compare the effects carvedilol and nebivolol on oxidative stress status in non-ischaemic heart failure (HF) patients.
  
  
  METHODS
  We included 56 symptomatic non-ischaemic HF patients with ejection fraction ≤ 40%. The patients were randomised to carvedilol (n = 29, 18 male) or nebivolol (n = 27, 18 male) groups. They were evaluated clinically and echocardiographically after target dose. We evaluated parameters associated with oxidative stress, such as alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), uric acid, total antioxidant capacity (TAC), total oxidative status (TOS), and oxidative stress index (OSI).
  
  
  RESULTS
  TAC, TOS, GGT, and ALP levels and OSI were comparable in both groups. Uric acid levels were lower in the carvedilol group compared with the nebivolol group (5.8 ± 1.6 vs. 7.0 ± 1.7 mg/dL, p = 0.01). In correlation analysis, uric acid (p < 0.001, r = 0.50) and TOS level (p < 0.001, r = 0.73) were positively correlated with OSI.
  
  
  CONCLUSIONS
  Carvedilol and nebivolol have similar effects on oxidative stress status in patients with non-ischaemic HF.
authors.affiliation: Department of Cardiology, Isparta State Hospital, Isparta, Turkey. drmustafa1979@hotmail.com.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karabacak
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Senol
authors.initials: S
authors.lastname: Tayyar
authors.forename: Hasan Aydin
authors.initials: HA
authors.lastname: Bas
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000368:Aged; D000975:Antioxidants / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology* / Q000627:therapeutic use; D000077261:Carvedilol; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol / Q000494:pharmacology* / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D014527:Uric Acid / Q000097:blood
chemical_list: D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D002227:Carbazoles; D011412:Propanolamines; D000068577:Nebivolol; D000077261:Carvedilol; D014527:Uric Acid