title: Emotional well-being of living kidney donors: findings from the RELIVE Study.
abstract: Following kidney donation, short-term quality of life outcomes compare favorably to US normative data but long-term effects on mood are not known. In the Renal and Lung Living Donors Evaluation Study (RELIVE), records from donations performed 1963-2005 were reviewed for depression and antidepressant use predonation. Postdonation, in a cross-sectional cohort design 2010-2012, donors completed the Patient Health Questionnaire (PHQ-9) depression screening instrument, the Life Orientation Test-Revised, 36-Item Short Form Health Survey and donation experience questions. Of 6909 eligible donors, 3470 were contacted and 2455 participated (71%). The percent with depressive symptoms (8%; PHQ-9>10) was similar to National Health and Nutrition Examination Survey participants (7%, p=0.30). Predonation psychiatric disorders were more common in unrelated than related donors (p=0.05). Postdonation predictors of depressive symptoms included nonwhite race OR=2.00, p=0.020), younger age at donation (OR=1.33 per 10 years, p=0.002), longer recovery time from donation (OR=1.74, p=0.0009), greater financial burden (OR=1.32, p=0.013) and feeling morally obligated to donate (OR=1.23, p=0.003). While cross-sectional prevalence of depression is comparable to population normative data, some factors identifiable around time of donation, including longer recovery, financial stressors, younger age and moral obligation to donate may identify donors more likely to develop future depression, providing an opportunity for intervention.
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN; The William J. von Liebig Transplant Center, Mayo Clinic, Rochester, MN.
authors.forename: S G
authors.initials: SG
authors.lastname: Jowsey
authors.forename: C
authors.initials: C
authors.lastname: Jacobs
authors.forename: C R
authors.initials: CR
authors.lastname: Gross
authors.forename: B A
authors.initials: BA
authors.lastname: Hong
authors.forename: E E
authors.initials: EE
authors.lastname: Messersmith
authors.forename: B W
authors.initials: BW
authors.lastname: Gillespie
authors.forename: T J
authors.initials: TJ
authors.lastname: Beebe
authors.forename: C
authors.initials: C
authors.lastname: Kew
authors.forename: A
authors.initials: A
authors.lastname: Matas
authors.forename: R D
authors.initials: RD
authors.lastname: Yusen
authors.forename: M
authors.initials: M
authors.lastname: Hill-Callahan
authors.forename: J
authors.initials: J
authors.lastname: Odim
authors.forename: S J
authors.initials: SJ
authors.lastname: Taler
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003863:Depression / Q000523:psychology; D004644:Emotions; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D019520:Living Donors / Q000523:psychology*; D008297:Male; D008875:Middle Aged
keywords: Clinical research; depression; donors and donation; donors and donation: donor follow-up; donors and donation: living; kidney transplantation; kidney transplantation: living donor; nephrology, social sciences; practice, health services and outcomes research