title: ANXA9gene expression in colorectal cancer: A novel marker for prognosis.
abstract: Annexin A9 (ANXA9) is involved with the interaction with membrane phospholipids in a Ca2+-dependent manner. A previous study has shown thatANXA9expression is associated with bone metastasis in breast cancer, whereas its significance in colorectal cancer (CRC) is unknown. The present study was comprised of 100 patients who underwent surgery for CRC. The correlation between gene expression and the clinical parameters of the patients was assessed. Patients with highANXA9expression were statistically susceptible to a relatively worse prognosis, and those with lowANXA9expression showed improved overall survival compared with those with high expression. In conclusion, the present data suggests thatANXA9expression is a prognostic factor in CRC patients.
authors.affiliation: Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan.
authors.forename: Norikatsu
authors.initials: N
authors.lastname: Miyoshi
authors.affiliation: Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Õhita 874-0838, Japan.
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.affiliation: Department of Surgery, National Hospital Organization Kure Medical Center, Kure, Hiroshima 737-0023, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamashita
authors.affiliation: Department of Surgery, Osaka General Medical Center, Osaka, Osaka 558-8558, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyazaki
authors.affiliation: Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.
authors.forename: Sumiko
authors.initials: S
authors.lastname: Nakagawa
authors.affiliation: Department of Frontier Science for Cancer and Chemotherapy, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
authors.affiliation: Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Noura
authors.affiliation: Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohue
authors.affiliation: Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537-8511, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yano
authors.affiliation: Department of Surgery, National Hospital Organization Kure Medical Center, Kure, Hiroshima 737-0023, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Doki
authors.affiliation: Department of Surgery, National Hospital Organization Kure Medical Center, Kure, Hiroshima 737-0023, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
keywords: ANXA9; colorectal cancer; prognosis