title: Pulmonary sarcoid-like granulomatosis after multiple vaccinations of a long-term surviving patient with metastatic melanoma.
abstract: Autoimmune side effects are frequent in patients with cancer treated with immune checkpoint-targeting antibodies, but are rare with cancer vaccines. Here, we present a case report on a patient with metastatic melanoma who developed pulmonary sarcoid-like granulomatosis following repetitive vaccinations with peptides and CpG. Despite multiple metastases, including one lesion in the brain, the patient is alive and well more than 13 years after the diagnosis of metastatic disease. The strongly activated tumor-specific CD8(+) T cells showed robust long-term memory and effector functions. It is possible that long-term survival and adverse autoimmune events may become more common for vaccines inducing robust anticancer immune responses as were present in this patient.
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Natacha
authors.initials: N
authors.lastname: Bordry
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Carla-Marisa
authors.initials: CM
authors.lastname: Costa-Nunes
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Laurène
authors.initials: L
authors.lastname: Cagnon
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Philippe O
authors.initials: PO
authors.lastname: Gannon
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Samia
authors.initials: S
authors.lastname: Abed-Maillard
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Petra
authors.initials: P
authors.lastname: Baumgaertner
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Timothy
authors.initials: T
authors.lastname: Murray
authors.affiliation: Department of Pathology, Lausanne University Hospital Center (CHUV), Lausanne, Switzerland.
authors.forename: Igor
authors.initials: I
authors.lastname: Letovanec
authors.affiliation: Department of Respiratory Medicine, CHUV, Lausanne, Switzerland.
authors.forename: Romain
authors.initials: R
authors.lastname: Lazor
authors.affiliation: Department of Oncology, CHUV and UNIL, Lausanne, Switzerland.
authors.forename: Hasna
authors.initials: H
authors.lastname: Bouchaab
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rufer
authors.affiliation: Department of Oncology, CHUV and UNIL, Lausanne, Switzerland.
authors.forename: Emanuela
authors.initials: E
authors.lastname: Romano
authors.affiliation: Department of Oncology, CHUV and UNIL, Lausanne, Switzerland.
authors.forename: Olivier
authors.initials: O
authors.lastname: Michielin
authors.affiliation: Clinical and Tumor Biology and Immunotherapy Unit, Department of Oncology and Ludwig Cancer Research Center, University of Lausanne (UNIL), Lausanne, Switzerland. doc@dspeiser.ch.
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Speiser
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity; D001932:Brain Neoplasms / Q000175:diagnosis / Q000556:secondary; D019496:Cancer Vaccines / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007150:Immunohistochemistry; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology / Q000378:metabolism; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D009362:Neoplasm Metastasis; D049268:Positron-Emission Tomography; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000951:Antigens, Neoplasm; D019496:Cancer Vaccines