title: [Sumatriptan plus naproxen for acute migraine attacks in adults].
abstract: It is of great importance to improve acute treatment of migraine attacks. Non-steroidal anti-inflammatory drugs (NSAID) and triptans have different anti-nociceptive effects, so a combination of these could theoretically lead to more effective acute migraine treatment. A recent meta-analysis investigated the combined effect of sumatriptan and naproxen and found it to be more effective than sumatriptan alone. However, the number needed to treat was high. Combined sumatriptan/naproxen should be reserved to those without efficient response to triptans.
authors.forename: Henrik W
authors.initials: HW
authors.lastname: Schytz
authors.affiliation: Dansk Hovedpinecenter, Glostrup Hospital, Nordre Ringvej 57, 2600 Glostrup. E-mail: bendtsen@dadlnet.dk.
authors.forename: Lars
authors.initials: L
authors.lastname: Bendtsen
mesh_terms: D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy*; D009288:Naproxen / Q000627:therapeutic use*; D012196:Review Literature as Topic; D058825:Serotonin 5-HT1 Receptor Agonists / Q000627:therapeutic use*; D018170:Sumatriptan / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D058825:Serotonin 5-HT1 Receptor Agonists; D009288:Naproxen; D018170:Sumatriptan