title: Miller Fisher syndrome with presynaptic neuromuscular transmission disorder.
abstract: Miller Fisher syndrome is defined by a triad of symptoms, namely areflexia, ataxia, and ophthalmoparesis. The ophthalmoparesis is mostly severe, undulating weakness of eye movements with ptosis and increased fatigability resembling a neuromuscular transmission disorder. We present a 52-year-old man with severe Miller Fisher syndrome with a high level of anti-GQ1b antibodies and a presynaptic type of neuromuscular transmission disorder. The diagnosis was confirmed by stimulated single-fiber electromyography with the use of a concentric needle electrode and various stimulation rates.
authors.affiliation: Department of Neurology, Regional Hospital and University of Pardubice, Kyjevská 44, CZ 532 03, Czech Republic. Electronic address: edvard.ehler@nemocnice-pardubice.cz.
authors.forename: Edvard
authors.initials: E
authors.lastname: Ehler
authors.affiliation: Department of Neurology, Regional Hospital and University of Pardubice, Kyjevská 44, CZ 532 03, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Latta
mesh_terms: D001259:Ataxia / Q000209:etiology; D001323:Autoantibodies / Q000097:blood*; D004172:Diplopia / Q000209:etiology; D004576:Electromyography / Q000379:methods; D005073:Evoked Potentials, Somatosensory; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019846:Miller Fisher Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D020511:Neuromuscular Junction Diseases / Q000150:complications* / Q000503:physiopathology; D009886:Ophthalmoplegia / Q000209:etiology; D012021:Reflex, Abnormal
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; C039129:GQ1b ganglioside
keywords: Fisher syndrome; Neuromuscular transmission disorder; Ophthalmoparesis; Single-fiber electromyography