title: Multiple lung adenocarcinomas associated with von hippel-lindau disease.
abstract: Lung adenocarcinoma has never before been reported to be associated with von Hippel-Lindau (VHL) disease. Here, we report a case of VHL disease in a patient who had metachronous multiple lung adenocarcinomas. The patient is a 64-year-old-woman with VHL disease. She underwent surgical resection of one adenocarcinoma and one atypical adenomatous hyperplasia. A second lung adenocarcinoma developed metachronously. A point mutation in the VHL gene was confirmed in DNA from a blood sample, and loss of heterozygosity at the VHL locus was detected in the lung adenocarcinoma. The VHL dysfunction may have a role in the development of multiple lung adenocarcinomas.
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan. Electronic address: koei@cg7.so-net.ne.jp.
authors.forename: Koei
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Osumi
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Matsuishi
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Eri
authors.initials: E
authors.lastname: Matsubara
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Fujino
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Hidekatsu
authors.initials: H
authors.lastname: Shibata
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Yoshimoto
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Shiraishi
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics / Q000601:surgery*; D000077192:Adenocarcinoma of Lung; D066246:ErbB Receptors / Q000235:genetics; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics / Q000601:surgery*; D008875:Middle Aged; D009154:Mutation; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics; D006623:von Hippel-Lindau Disease / Q000150:complications*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; D066246:ErbB Receptors; C497446:VHL protein, human