title: Clinical aspects of urea transporters.
abstract: Jk antigens, which were identified as urea transporter B (UT-B) in the plasma membrane of erythrocytes, and which determine the Kidd blood type in humans, are involved in transfusion medicine, and even in organ transplantation. The Jk(a-b-) blood type is a consequence of a silent Slc14A1 gene caused by various mutations related to lineage. In addition, the specific mutations related to hypertension and metabolic syndrome cannot be ignored. Genome-wide association studies established Slc14A1 as a related gene of bladder cancer and some genotypes are associated with higher morbidity. This chapter aims to introduce the clinical significance of urea transporters.
authors.affiliation: Department of Anatomy and Neuroscience Center, Basic Medical College, Chongqing Medical University, Yixueyuan Road 1, Chongqing, 400016, China, ranjianhua@cqmu.edu.cn.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ran
authors.forename: Hongkai
authors.initials: H
authors.lastname: Wang
authors.forename: Tinghai
authors.initials: T
authors.lastname: Hu
mesh_terms: D019943:Amino Acid Substitution; D004912:Erythrocytes / Q000378:metabolism*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D007667:Kidd Blood-Group System / Q000235:genetics*; D026901:Membrane Transport Proteins / Q000235:genetics*; D009154:Mutation; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics; D000096982:Urea Transporters
chemical_list: D007667:Kidd Blood-Group System; D026901:Membrane Transport Proteins; D000096982:Urea Transporters