title: Dietary factors and risk of pancreatic cancer: a multi-centre case-control study in China.
abstract: BACKGROUND
  Pancreatic cancer is the sixth leading cause of cancer death with an increasing trend in China. Dietary intake is believed to play an important role in pancreatic cancer carcinogenesis. The aim of this paper was to evaluate associations between some dietary factors and risk of pancreatic cancer in a multi-centre case-control study conducted in China.
  
  
  METHODS
  Cases (n=323) were ascertained from four provincial cancer hospitals. Controls (n=323) were randomly selected from the family members of patients without pancreatic cancer in the same hospitals, 1:1 matched to cases by gender, age and study center. Data were collected with a questionnaire by personal interview. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using conditional logistic regression.
  
  
  RESULTS
  Tea intake (OR =0.49; 95%CI: 0.30-0.80) was associated with a half reduction in risk of pancreatic cancer. Reduced vegetable consumption (P trend: 0.04) was significant related to pancreatic cancer. Although no significant association was found for meat and fruit, ORs were all above or below the reference group. A protective effect was found for fruit (OR=1.73 for consumption of 1-2 times/week vs more than 3 times/week; 95%CI: 1.05-2.86). A high intake of meat was associated to a higher risk of pancreatic cancer (OR=0.59 for consumption of 1-2 times /week vs. more than 3 times /week; 95%CI: 0.35-0.97).
  
  
  CONCLUSIONS
  The present study supports fruit consumption to reduce pancreatic cancer risk and indicates that high consumption of meat is related to an elevated risk. Direct inverse relations with tea and vegetable intake were also confirmed.
authors.affiliation: Henan Cancer Research and Control Office, Henan Cancer Hospital, Zhengzhou, China E-mail : xbsun21@sina.com, hytong69@yahoo.com.
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Liu
authors.forename: Wan-Qing
authors.initials: WQ
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Meng-Meng
authors.initials: MM
authors.lastname: Yin
authors.forename: Xi-Bin
authors.initials: XB
authors.lastname: Sun
authors.forename: Yu-Tong
authors.initials: YT
authors.lastname: He
mesh_terms: D016022:Case-Control Studies; D002681:China; D004032:Diet / Q000009:adverse effects*; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000209:etiology* / Q000517:prevention & control; D011379:Prognosis; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014675:Vegetables