title: Inflammasome activation in response to dead cells and their metabolites.
abstract: Cell death cannot go unnoticed. It demands that the surrounding cells clear away the corpses in a manner appropriate to the type of cell death. Dying cells represent a threat to the body that should be eliminated by the host immune response. Inflammasome activation followed by IL-1alpha release and IL-1beta maturation is crucial for tackling pathological conditions, including infections, whereas inflammasome activation precedes inflammatory pyroptotic cell death. On the other hand, recent studies have shown that the inflammasome plays an important role in the pathogenesis of metabolic diseases, including obesity, diabetes, and atherosclerosis. Here, we review current knowledge of the association between cell death, excess metabolites, and inflammasome activation as it relates to chronic inflammatory diseases.
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8605, Japan. Electronic address: kono@med.teikyo-u.ac.jp.
authors.forename: Hajime
authors.initials: H
authors.lastname: Kono
authors.affiliation: Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173-8605, Japan; Department of Allergy and Rheumatology, The University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kimura
authors.affiliation: Institute of Innate Immunity, University Hospital, University of Bonn, 53127 Bonn, Germany; Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA; German Center for Neurodegenerative Diseases, 53175 Bonn, Germany.
authors.forename: Eicke
authors.initials: E
authors.lastname: Latz
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology; D016923:Cell Death; D008078:Cholesterol, LDL / Q000276:immunology; D006073:Gout / Q000276:immunology; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D015275:Tumor Lysis Syndrome / Q000276:immunology
chemical_list: D008078:Cholesterol, LDL; D058847:Inflammasomes