title: CD44 deficiency leads to decreased proinflammatory cytokine production in lung induced by PCV2 in mice.
abstract: Porcine circovirus type 2 (PCV2) is the primary etiological agent of postweaning multisystemic wasting syndrome (PMWS). CD44 is a widely expressed class I transmembrane glycoprotein implicated in immunological and inflammatory responses. In previous studies, the role of CD44 in host defense against microorganism infection remains controversial. The role of CD44 in host defense against PCV2 infection has never been studied before. In this study, we investigated the role of CD44 in the development of pneumonia induced by PCV2 in mice model. Upon infection, CD44 mRNA level in lung tissue was upregulated, and we confirmed a detrimental role of CD44 in host defense against PCV2 infection. The results demonstrated that CD44 deficiency could result in decreased proinflammatory cytokine production in lung induced by PCV2 in mice, suggesting a previously unrecognized role for CD44 in the development of pneumonia response to PCV2 infection.
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
authors.forename: Linbing
authors.initials: L
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
authors.forename: Chunhe
authors.initials: C
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China.
authors.forename: Yaosheng
authors.initials: Y
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. Electronic address: liuxh8@mail.sysu.edu.cn.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D018173:Circoviridae Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology; D017925:Circovirus / Q000502:physiology*; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018960:Hyaluronan Receptors / Q000235:genetics* / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000503:physiopathology / Q000821:virology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013047:Specific Pathogen-Free Organisms
chemical_list: C476399:Cd44 protein, mouse; D016207:Cytokines; D018960:Hyaluronan Receptors
keywords: CD44; Pneumonia; Porcine circovirus type 2