title: Genetic networks governing heart development.
abstract: Animal genomes contain a code for construction of the body plan from a fertilized egg. Understanding how genome information is deciphered to create the complex multilayered regulatory systems that drive organismal development, and which become altered in disease, is one of the greatest challenges in the biological sciences. The development of methods that effectively represent and communicate the complexity inherent in gene regulatory networks remains a major barrier. This review introduces the philosophy of systems biology and discusses recent progress in understanding the development of the heart at a systems biology level.
authors.affiliation: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia.
authors.forename: Ashley J
authors.initials: AJ
authors.lastname: Waardenberg
authors.affiliation: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.
authors.forename: Mirana
authors.initials: M
authors.lastname: Ramialison
authors.affiliation: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia.
authors.forename: Romaric
authors.initials: R
authors.lastname: Bouveret
authors.affiliation: Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia St. Vincent's Clinical School, University of New South Wales Medicine, Kensington, New South Wales 2052, Australia School of Biotechnology and Biomolecular Sciences, University of New South Wales Faculty of Science, New South Wales 2052, Australia Stem Cells Australia, Melbourne Brain Centre, University of Melbourne, Victoria 3010, Australia.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Harvey
mesh_terms: D000818:Animals; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000254:growth & development; D044127:Epigenesis, Genetic / Q000235:genetics; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D053263:Gene Regulatory Networks / Q000235:genetics* / Q000502:physiology; D016678:Genome / Q000235:genetics; D006321:Heart / Q000196:embryology / Q000254:growth & development*; D006801:Humans; D051379:Mice; D041641:Musculoskeletal Development; D022661:RNA, Untranslated / Q000235:genetics / Q000502:physiology
chemical_list: D022661:RNA, Untranslated