title: Cellular senescence and the aging brain.
abstract: Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of mitotically competent cells to prevent malignant transformation. Senescent cells accumulate with age in a variety of human and mouse tissues where they express a complex 'senescence-associated secretory phenotype' (SASP). The SASP includes many pro-inflammatory cytokines, chemokines, growth factors and proteases that have the potential to cause or exacerbate age-related pathology, both degenerative and hyperplastic. While cellular senescence in peripheral tissues has recently been linked to a number of age-related pathologies, its involvement in brain aging is just beginning to be explored. Recent data generated by several laboratories suggest that both aging and age-related neurodegenerative diseases are accompanied by an increase in SASP-expressing senescent cells of non-neuronal origin in the brain. Moreover, this increase correlates with neurodegeneration. Senescent cells in the brain could therefore constitute novel therapeutic targets for treating age-related neuropathologies.
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Shankar J
authors.initials: SJ
authors.lastname: Chinta
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Georgia
authors.initials: G
authors.lastname: Woods
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Rane
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Demaria
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA; Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.affiliation: Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: jandersen@buckinstitute.org.
authors.forename: Julie K
authors.initials: JK
authors.lastname: Andersen
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology*; D049109:Cell Proliferation / Q000502:physiology; D016922:Cellular Senescence / Q000502:physiology*; D006801:Humans; D051379:Mice; D008959:Models, Neurological; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology
keywords: Aging; Brain; Cellular senescence; Neurodegeneration; Senescence associated secretory phenotype