title: Synthetic advances in macrosphelides: natural anticancer agents.
abstract: Total synthesis of macrosphelides is summarized. Synthetic approaches contain the preparation of key fragments and the final ring-closure reaction for unique 16- or 15-membered macrolactone skeletons.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju daero, Jinju, Gyeongnam 660-701, Korea. million@gnu.ac.kr.
authors.forename: Seung-Mann
authors.initials: SM
authors.lastname: Paek
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001688:Biological Products / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D006571:Heterocyclic Compounds