title: [Placenta of normal women and of patients with bronchial asthma of various degrees of severity (immunohistochemical and histological study)].
abstract: The aim of the study was to examine the immunomorphological features and expression of immunohistochemical markers that indicate the presence of immune inflammation in the placenta in normal pregnancy and in pregnancy complicated by bronchial asthma (BA) of varying degrees of severity. The of 80 samples of placenta from patients with BA were studied immunohistochemically and histologically to demonstrate the fixation of C3 fraction of complement, fibrinogen, IL-4, IL-6, IgA, IgM, IgG, and the expression of CD31, CD35, CD57 and CD83 molecules. The largest number of immune deposits fixed in the placenta and damaging the structures of the placental barrier (vascular endothelium and syncytiotrophoblast membranes) was found in women with moderate to severe BA. Their precipitation lead to the development of immunopathological process in the placenta and could result in placental insufficiency, adversely affecting the course of pregnancy and childbirth. The presence of pathogenic immune complexes in the placenta and the detection of antigen-presenting cells in areas of immunological inflammation in the placenta of women with BA are associated with the unfavorable course of pregnancy, parturition and could be a predictor of the possible development of allergic diseases in children.
authors.forename: L B
authors.initials: LB
authors.lastname: Zybzhitskaia
authors.forename: E A
authors.initials: EA
authors.lastname: Shapovalova
authors.forename: O V
authors.initials: OV
authors.lastname: Lavrova
authors.forename: Iu R
authors.initials: IuR
authors.lastname: Dymarskaia
authors.forename: O N
authors.initials: ON
authors.lastname: Arzhanova
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis*; D001249:Asthma; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D007150:Immunohistochemistry; D015847:Interleukin-4 / Q000096:biosynthesis*; D015850:Interleukin-6 / Q000096:biosynthesis*; D010920:Placenta / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
chemical_list: D015703:Antigens, CD; C508598:IL4 protein, human; C508600:IL6 protein, human; D007136:Immunoglobulins; D015850:Interleukin-6; D015847:Interleukin-4