title: Epigenetic pathways and glioblastoma treatment: insights from signaling cascades.
abstract: There is an urgent need to identify novel therapies for glioblastoma (GBM) as most therapies are ineffective. A first step in this process is to identify and validate targets for therapeutic intervention. Epigenetic modulators have emerged as attractive drug targets in several cancers including GBM. These epigenetic regulators affect gene expression without changing the DNA sequence. Recent studies suggest that epigenetic regulators interact with drivers of GBM cell and stem-like cell proliferation. These drivers include components of the Notch, Hedgehog, and Wingless (WNT) pathways. We highlight recent studies connecting epigenetic and signaling pathways in GBM. We also review systems and big data approaches for identifying patient specific therapies in GBM. Collectively, these studies will identify drug combinations that may be effective in GBM and other cancers.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Center for Therapeutic Innovation, University of Miami, Florida, 33136.
authors.forename: Bryce K
authors.initials: BK
authors.lastname: Allen
authors.forename: Vasileios
authors.initials: V
authors.lastname: Stathias
authors.forename: Marie E
authors.initials: ME
authors.lastname: Maloof
authors.forename: Dusica
authors.initials: D
authors.lastname: Vidovic
authors.forename: Emily F
authors.initials: EF
authors.lastname: Winterbottom
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Capobianco
authors.forename: Jennifer
authors.initials: J
authors.lastname: Clarke
authors.forename: Stephan
authors.initials: S
authors.lastname: Schurer
authors.forename: David J
authors.initials: DJ
authors.lastname: Robbins
authors.forename: Nagi G
authors.initials: NG
authors.lastname: Ayad
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D005909:Glioblastoma / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D035683:MicroRNAs
keywords: EPIGENETICS; GLIOBLASTOMA; HEDGEHOG; NOTCH; SIGNALING PATHWAYS; WINGLESS