title: Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in vivo.
abstract: We here report on the in vitro activity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, including Candida albicans, Candida glabrata, Candida dubliniensis, Candida krusei, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. We validated the in vivo efficacy of orally administered toremifene against C. albicans and S. aureus biofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium Department of Plant Systems Biology, VIB, Ghent, Belgium.
authors.forename: Kaat
authors.initials: K
authors.lastname: De Cremer
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delattin
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Katrijn
authors.initials: K
authors.lastname: De Brucker
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Peeters
authors.affiliation: Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Belgium.
authors.forename: Soña
authors.initials: S
authors.lastname: Kucharíková
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Evelien
authors.initials: E
authors.lastname: Gerits
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Natalie
authors.initials: N
authors.lastname: Verstraeten
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Jan
authors.initials: J
authors.lastname: Michiels
authors.affiliation: Department of Molecular Microbiology, VIB, KU Leuven, Leuven, Belgium Laboratory of Molecular Cell Biology, KU Leuven, Leuven, Belgium.
authors.forename: Patrick
authors.identifier: http://orcid.org/0000-0002-1542-897X
authors.initials: P
authors.lastname: Van Dijck
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium Department of Plant Systems Biology, VIB, Ghent, Belgium Bruno.Cammue@biw.kuleuven.be.
authors.forename: Bruno P A
authors.initials: BP
authors.lastname: Cammue
authors.affiliation: Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.
authors.forename: Karin
authors.initials: K
authors.lastname: Thevissen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D002179:Candidiasis, Cutaneous / Q000188:drug therapy* / Q000382:microbiology; D002408:Catheters, Indwelling; D005260:Female; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development; D017312:Toremifene / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D020845:Selective Estrogen Receptor Modulators; D017312:Toremifene