title: Novel ionically crosslinked acrylamide-grafted poly(vinyl alcohol)/sodium alginate/sodium carboxymethyl cellulose pH-sensitive microspheres for delivery of Alzheimer's drug donepezil hydrochloride: Preparation and optimization of release conditions.
abstract: In this work, the graft copolymer, poly(vinyl alcohol)-grafted polyacrylamide (PVA-g-PAAm), was synthesized and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and elemental analysis. Microspheres of PVA-g-PAAm/sodium alginate (NaAlg)/sodium carboxymethyl cellulose (NaCMC) were prepared by the emulsion-crosslinking method and used for the delivery of an Alzheimer's drug, donepezil hydrochloride (DP). The release of DP increased with the increase in drug/polymer ratio (d/p) and PVA-g-PAAm/NaAlg/NaCMC ratio, while it decreased with the increase in the extent of crosslinking. The optimum DP release was obtained as 92.9% for a PVA-g-PAAm/NaAlg/NaCMC ratio of 1/2/1, d/p ratio of 1/8, and FeCl3 concentration of 7% (w/v).
authors.affiliation: a Department of Chemistry , Science and Arts Faculty, Afyon Kocatepe University , Afyonkarahisar , Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Bulut
authors.affiliation: b Department of Chemistry , Science Faculty, Gazi University , Ankara , Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Şanlı
mesh_terms: D020106:Acrylamide / Q000737:chemistry*; D000464:Alginates / Q000737:chemistry*; D000544:Alzheimer Disease / Q000188:drug therapy*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry; D000077265:Donepezil; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D005290:Ferric Compounds / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007189:Indans / Q000737:chemistry* / Q000627:therapeutic use; D007700:Kinetics; D008863:Microspheres; D010880:Piperidines / Q000737:chemistry* / Q000627:therapeutic use; D011142:Polyvinyl Alcohol / Q000737:chemistry*
chemical_list: D000464:Alginates; D002712:Chlorides; D004337:Drug Carriers; D005290:Ferric Compounds; D006603:Hexuronic Acids; D007189:Indans; D010880:Piperidines; D020106:Acrylamide; D020723:Glucuronic Acid; D000077265:Donepezil; D011142:Polyvinyl Alcohol; D002266:Carboxymethylcellulose Sodium; C024555:ferric chloride
keywords: crosslinking; donepezil hydrochloride; drug delivery systems; graft copolymer; microspheres