title: Hb Hope: A Rare Variant of Haemoglobin-Forged a Rise in HbA1c on Immunoturbidimetric Assay.
abstract: Glycosylated hemoglobin (HbA1c) determination is a powerful means for assessing the evaluation and management of patients with diabetes mellitus. Hemoglobin (Hb) variants and chemically modified derivatives of Hb can affect the accuracy of measurement of HbA1c done by various analytical methods. We report a patient with a rare variant of Hb (Hb Hope) that caused an abnormally high value of HBA1c when assayed using immunoturbidimetric assay ("Tina-quant" 2nd generation assay) and also elucidate the nature of the variant.
authors.affiliation: Department of Biochemistry, IMS & SUM Hospital, Sikshya O Anusandhan University, Bhubaneswar, Odisha India.
authors.forename: Bratati
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, IMS & SUM Hospital, Sikshya O Anusandhan University, Bhubaneswar, Odisha India.
authors.forename: Debasis Debadatta
authors.initials: DD
authors.lastname: Behera
authors.affiliation: Department of Biochemistry, IMS & SUM Hospital, Sikshya O Anusandhan University, Bhubaneswar, Odisha India.
authors.forename: Neelam
authors.initials: N
authors.lastname: Mehta
authors.affiliation: Department of Biochemistry, IMS & SUM Hospital, Sikshya O Anusandhan University, Bhubaneswar, Odisha India.
authors.forename: Seema
authors.initials: S
authors.lastname: Das
keywords: Diabetes mellitus; Glycosylated hemoglobin; Immunoturbidimetric assay