title: The use of (68)Ga DOTATATE PET/CT for diagnostic assessment and monitoring of (177)Lu DOTATATE therapy in pituitary carcinoma.
abstract: A 68-year-old man, with a history of pituitary surgery and radiation therapy for pituitary macroadenoma 20 years earlier, presented with a pituitary mass and enlarging lesions within the posterior fossa and spinal canal. Biopsy revealed low-grade pituitary carcinoma. PET/CT scan showed multiple foci of increased Ga DOTATATE activity including pituitary and posterior fossa lesions. After 3 fractions of Lu DOTATATE therapy, the tumor remained stable over 4 years on MRI and Ga DOTATATE scans. This case illustrates the benefit of Ga DOTATATE PET/CT in malignant pituitary disease to assess potential for somatostatin receptor therapy with Lu DOTATATE and monitor treatment.
authors.affiliation: From the *Institute of Nuclear Medicine, University College Hospital, London, United Kingdom; †Azerbaijan National Center of Oncology, Baku, Azerbaijan; and ‡Division of Neuropathology, Institute of Neurology, UCL, London, United Kingdom.
authors.forename: Fuad
authors.initials: F
authors.lastname: Novruzov
authors.forename: Jamil A
authors.initials: JA
authors.lastname: Aliyev
authors.forename: Zane
authors.initials: Z
authors.lastname: Jaunmuktane
authors.forename: Jamshed B
authors.initials: JB
authors.lastname: Bomanji
authors.forename: Irfan
authors.initials: I
authors.lastname: Kayani
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D015282:Octreotide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; C513399:gallium Ga 68 dotatate; C447941:lutetium Lu 177 dotatate; D015282:Octreotide