title: Multiple invasion mechanisms and different intracellular Behaviors: a new vision of Salmonella-host cell interaction.
abstract: Salmonella is a facultative intracellular bacterium found within a variety of phagocytic and nonphagocytic cells in vitro and in vivo For decades, it has been accepted that Salmonella can enter cells only through a Trigger mechanism mediated by a type three secretion system, called T3SS-1. However, recent researches have shown that this bacterium can use other invasion pathways mediating either Trigger or Zipper entry processes. Following eukaryotic cell invasion, Salmonella has to ensure its survival and proliferation within host cells. To do so, this bacterium resides either within a membrane-bound vacuole or freely within host cell cytosol. It is not clear why Salmonella has developed these alternate mechanisms for cell invasion and proliferation, but this provides a new insight into the mechanisms leading to Salmonella-induced diseases. Thus, the aim of this review is to show the evolution of Salmonella-host cell interaction paradigms by summarizing the different strategies used by Salmonella serotypes to invade and proliferate into eukaryotic cells.
authors.affiliation: Institut National de la Recherche Agronomique, UMR1282 Infectiologie et Santé Publique, Nouzilly, France.|Université François Rabelais, UMR1282 Infectiologie et Santé Publique, Tours, France.|Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'environnement et du travail, Laboratoire de Ploufragan-Plouzané, Unité Hygiène et Qualité des Produits Avicoles et Porcins, Plouragan, France.
authors.forename: Zineb
authors.initials: Z
authors.lastname: Boumart
authors.affiliation: Institut National de la Recherche Agronomique, UMR1282 Infectiologie et Santé Publique, Nouzilly, France.|Université François Rabelais, UMR1282 Infectiologie et Santé Publique, Tours, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Velge
authors.affiliation: Institut National de la Recherche Agronomique, UMR1282 Infectiologie et Santé Publique, Nouzilly, France Agnes.Wiedemann@tours.inra.fr.|Université François Rabelais, UMR1282 Infectiologie et Santé Publique, Tours, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Wiedemann
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005057:Eukaryotic Cells / Q000382:microbiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D051379:Mice; D008954:Models, Biological; D012475:Salmonella / Q000276:immunology*; D065288:Serogroup
keywords: Salmonella; invasion; proliferation