title: Finding a cure for human immunodeficiency virus-1 infection.
abstract: Remarkable advances have been made in the treatment of human immunodeficiency virus (HIV)-1 infection, but in the entire history of the epidemic, only 1 patient has been cured. Herein we review the fundamental mechanisms that render HIV-1 infection difficult to cure and then discuss recent clinical and experimental situations in which some form of cure has been achieved. Finally, we consider approaches that are currently being taken to develop a general cure for HIV-1 infection.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, 733, North Broadway, Baltimore, MD 21205, USA.
authors.forename: Joel N
authors.initials: JN
authors.lastname: Blankson
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, 733, North Broadway, Baltimore, MD 21205, USA.
authors.forename: Janet D
authors.initials: JD
authors.lastname: Siliciano
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, 733, North Broadway, Baltimore, MD 21205, USA; Howard Hughes Medical Institute, 733, North Broadway, Baltimore, MD 21205, USA. Electronic address: rsiliciano@jhmi.edu.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Siliciano
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy* / Q000821:virology; D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D017735:Virus Latency
chemical_list: D019380:Anti-HIV Agents
keywords: Antiretroviral therapy; Cure; HIV; Latent reservoir; Retroviral persistence