title: Plasma adiponectin is inversely associated with antenatal anxiety: Results from a Brazilian cohort.
abstract: Antenatal anxiety may increase the risk of undesirable birth outcomes. Studies have demonstrated an association between adiponectin and anxiety, but this issue has not been investigated during pregnancy. This study aimed to evaluate the association between plasma adiponectin, measured throughout gestation, and the occurrence of anxiety at late pregnancy (30-36th weeks). A prospective cohort was investigated in Rio de Janeiro, Brazil. Healthy pregnant women, aged 20-40 years, were evaluated between gestational weeks 5-13, 22-26 and 30-36. State anxiety was measured using a validated version of the State-Trait Anxiety Inventory, and women were categorized as high (score≥50, n=30) or low anxiety (score<50, n=129). Plasma samples for all trimesters were analyzed using commercial ELISA kits to determine adiponectin concentrations (U/mL). Statistical analysis involved student's t-tests, chi-square, Pearson correlation, multiple logistic regression and linear mixed effects (LME) regression to model longitudinal trends of adiponectin, stratified for anxiety categories. Women with higher anxiety scores had lower mean concentrations of 3rd trimester adiponectin compared with those with lower scores (7.9; 95% CI: 7.0-8.9 vs. 9.9; 95% CI: 9.1-10.7). Women with 3rd trimester adiponectin values within the third tertile (10.47-26.57U/mL) were less likely to have high antenatal anxiety (adjusted OR=0.30; 95% CI: 0.09-0.98) compared with those within the first tertile (2.25-7.08U/mL). Unlike women with low levels of anxiety, those with high levels had a significant decrease of plasma adiponectin throughout pregnancy (β=-0.07; 95% CI: -0.13-[-0.01] vs. β=-0.01; 95% CI: -0.05 to 0.03). Multiple LME model indicated higher adiponectin throughout pregnancy for women with low anxiety (β=-1.57; 95% CI: -2.78-[-0.37]). In conclusion, plasma adiponectin throughout pregnancy was inversely associated with antenatal anxiety.
authors.affiliation: National School of Public Health, Oswaldo Cruz Foundation, Rua Leopoldo Bulhões, 1480 Manguinhos, Rio de Janeiro, RJ, Brazil; Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: frebelos@gmail.com.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Rebelo
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: thatiana.pinto@gmail.com.
authors.forename: Thatiana
authors.initials: T
authors.lastname: de Jesus Pereira Pinto
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: nutrianabeatriz@gmail.com.
authors.forename: Ana Beatriz
authors.initials: AB
authors.lastname: Franco-Sena
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: jaquelepsch@gmail.com.
authors.forename: Jaqueline
authors.initials: J
authors.lastname: Lepsch
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: camilabenaimnutri@gmail.com.
authors.forename: Camila
authors.initials: C
authors.lastname: Benaim
authors.affiliation: National School of Public Health, Oswaldo Cruz Foundation, Rua Leopoldo Bulhões, 1480 Manguinhos, Rio de Janeiro, RJ, Brazil. Electronic address: stru@fiocruz.br.
authors.forename: Claudio José
authors.initials: CJ
authors.lastname: Struchiner
authors.affiliation: Nutritional Epidemiology Observatory, Department of Social and Applied Nutrition, Institute of Nutrition Josué de Castro. Rio de Janeiro Federal University, Avenida Carlos Chagas Filho, 367/CCS-Bloco J-2° andar, sala 29. Cidade Universitária-Ilha do Fundão, Rio de Janeiro, RJ, Brazil. Electronic address: Gilberto.kac@gmail.com.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Kac
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D001007:Anxiety / Q000097:blood* / Q000175:diagnosis; D001938:Brazil; D015331:Cohort Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D052242:Adiponectin
keywords: Adiponectin; Anxiety; Cohort; Mental health; Pregnancy