title: Complications in skin grafts when continuing antithrombotic therapy prior to cutaneous surgery requiring skin grafting: A systematic review.
abstract: The risk of postoperative bleeding and wound healing complications in skin grafts among anticoagulated patients undergoing cutaneous surgery has not been firmly established. The objective was to examine the literature and assess the risk of postoperative bleeding or wound healing complications in skin grafts among anticoagulated patients, compared with patients who discontinue or patients who are not receiving antithrombotic therapy prior to cutaneous surgery requiring skin grafting. A systematic review examining the effect of antithrombotic therapy on cutaneous surgery was performed according to the PRISMA-guidelines. PubMed and Embase databases were primarily searched for relevant literature in the period from the start date of each database to 2014. A total of eight studies representing 443 patients met criteria for inclusion. No randomised controlled trials were found; the included studies were of prospective and retrospective design. Most of the reviewed studies suggest that the use of antithrombotic therapy can increase the risk of bleeding complications in skin grafts. These complications are only wound threatening and not life threatening. Therefore, this is of concern mostly in terms of hemostasis by the surgeon and good pressure dressings. Care should be taken when operating on anticoagulated patients undergoing cutaneous surgery requiring skin grafting. However, graft failure is rare and, given the risk of thrombotic events, the reviewed studies recommend continuing all medically necessary antithrombotic therapy. The limitations of this study are the small sample sizes and the level of evidence; hence, more research is needed to substantiate these preliminary findings.
authors.affiliation: Department of Plastic & Reconstructive Surgery, Aalborg University Hospital , Aalborg , Denmark.
authors.forename: Reem D
authors.initials: RD
authors.lastname: Jarjis
authors.forename: Lone
authors.initials: L
authors.lastname: Jørgensen
authors.forename: Kenneth
authors.initials: K
authors.lastname: Finnerup
authors.forename: Lene
authors.initials: L
authors.lastname: Birk-Sørensen
mesh_terms: D062109:Dermatologic Surgical Procedures; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D019106:Postoperative Hemorrhage / Q000139:chemically induced; D016038:Skin Transplantation / Q000009:adverse effects*; D014945:Wound Healing
chemical_list: D005343:Fibrinolytic Agents
keywords: antithrombotic therapy; bleeding; complications; cutaneous surgery; skin graft