title: IGF-1 and ADMA levels are inversely correlated in nondiabetic ankylosing spondylitis patients undergoing anti-TNF-alpha therapy.
abstract: Like rheumatoid arthritis, ankylosing spondylitis (AS) is also an inflammatory disease associated with accelerated atherosclerosis and the presence of metabolic syndrome (MeS) features. AS patients often display osteoporosis as well as new bone formation. Insulin-like growth factor 1 (IGF-1) is a protein involved in both inflammation and bone metabolism. In the present study we assessed whether disease activity, systemic inflammation, MeS features, adipokines, and biomarkers of endothelial activation were associated with IGF-1 and insulin-like growth factor binding protein-3 (IGFBP-3) levels in a series of 30 nondiabetic AS patients without CV disease undergoing TNF-α antagonist-infliximab therapy. All determinations were made in the fasting state, immediately before an infliximab infusion. Although no association of IGF-1 and IGFBP-3 levels with angiopoietin-2 or osteopontin was found, an inverse correlation between IGF-1 levels and asymmetric dimethylarginine (ADMA), an endogenous endothelial nitric oxide synthase inhibitor that impairs nitric oxide production and secretion promoting endothelial dysfunction, was found (r=-0.397; P=0.04). However, no significant association was found between IGF-1 and IGFBP-3 levels and disease activity, systemic inflammation, metabolic syndrome features, or adipokines. In conclusion, in nondiabetic patients with AS undergoing periodic anti-TNF-α therapy, IGF-1 and ADMA are inversely correlated.
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Fernanda
authors.identifier: 0000-0003-3612-1448
authors.initials: F
authors.lastname: Genre
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: López-Mejías
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Rueda-Gotor
authors.affiliation: Rheumatology Division, Hospital Lucus Augusti, 27003 Lugo, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Begoña
authors.identifier: 0000-0002-3321-3016
authors.initials: B
authors.lastname: Ubilla
authors.affiliation: Endocrinology Division, Hospital Clínico Universitario, 47005 Valladolid, Spain.
authors.forename: Aurelia
authors.initials: A
authors.lastname: Villar-Bonet
authors.affiliation: Oncology Division, Hospital Del Bierzo, Ponferrada, 24411 León, Spain.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Carnero-López
authors.affiliation: Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IDIVAL and CIBER Epidemiología y Salud Pública (CIBERESP), 39011 Santander, Spain.
authors.forename: Inés
authors.initials: I
authors.lastname: Gómez-Acebo
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain.
authors.forename: Trinitario
authors.initials: T
authors.lastname: Pina
authors.affiliation: Cardiology Division, Hospital Lucus Augusti, 27003 Lugo, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Juanatey
authors.affiliation: Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, IDIVAL and CIBER Epidemiología y Salud Pública (CIBERESP), 39011 Santander, Spain.
authors.forename: Javier
authors.identifier: 0000-0002-9400-0989
authors.initials: J
authors.lastname: Llorca
authors.affiliation: Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, 39011 Santander, Spain ; Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D054392:Adipokines / Q000235:genetics; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D001120:Arginine / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D000069285:Infliximab; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D053495:Osteopontin / Q000378:metabolism; D010024:Osteoporosis / Q000150:complications / Q000235:genetics / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D054392:Adipokines; D000911:Antibodies, Monoclonal; C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D014409:Tumor Necrosis Factor-alpha; D053495:Osteopontin; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D007334:Insulin-Like Growth Factor I; D001120:Arginine; D000069285:Infliximab; D019001:Nitric Oxide Synthase