title: Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders.
abstract: Peptides synthesized in endocrine cells in the gastrointestinal tract and neurons are traditionally considered regulators of metabolism, energy intake, and appetite. However, recent work has demonstrated that many of these peptides act on corticostriatal-limbic circuitry and, in turn, regulate addictive behaviors. Given that alcohol is a source of energy and an addictive substance, it is not surprising that increasing evidence supports a role for gut-brain peptides specifically in alcohol use disorders (AUD). In this review, we discuss the effects of several gut-brain peptides on alcohol-related behaviors and the potential mechanisms by which these gut-brain peptides may interfere with alcohol-induced changes in corticostriatal-limbic circuitry. This review provides a summary of current knowledge on gut-brain peptides focusing on five peptides: neurotensin, glucagon-like peptide 1, ghrelin, substance P, and neuropeptide Y. Our review will be helpful to develop novel therapeutic targets for AUD.
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine Rochester, MN, USA ; Neurobiology of Disease Program, Mayo Clinic College of Medicine Rochester, MN, USA.
authors.forename: Chelsea A
authors.initials: CA
authors.lastname: Vadnie
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine Rochester, MN, USA ; Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, InJe University Seoul, South Korea.
authors.forename: Jun Hyun
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Psychiatry and Psychology, Mayo Clinic College of Medicine Rochester, MN, USA.
authors.forename: Noha
authors.initials: N
authors.lastname: Abdel Gawad
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine Rochester, MN, USA ; Department of Psychiatry and Psychology, Mayo Clinic College of Medicine Rochester, MN, USA.
authors.forename: Ada Man Choi
authors.initials: AM
authors.lastname: Ho
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine Rochester, MN, USA ; Neurobiology of Disease Program, Mayo Clinic College of Medicine Rochester, MN, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hinton
authors.affiliation: Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine Rochester, MN, USA ; Neurobiology of Disease Program, Mayo Clinic College of Medicine Rochester, MN, USA ; Department of Psychiatry and Psychology, Mayo Clinic College of Medicine Rochester, MN, USA.
authors.forename: Doo-Sup
authors.initials: DS
authors.lastname: Choi
keywords: GLP-1; NPY; alcohol; ghrelin; neurotensin; peptide; substance P