title: Fatty acid synthase-associated protein with death domain: a prognostic factor for survival in patients with nasopharyngeal carcinoma.
abstract: Fatty acid synthase-associated protein with death domain (FADD) is a key adaptor protein that bridges a death receptor (eg, death receptor 5) to caspase 8 to form the death-inducing signaling complex during apoptosis. The expression and prognostic impact of FADD in nasopharyngeal carcinoma (NPC) have not been well studied. This study focused on detecting FADD expression and analyzing its prognostic impact on NPC. FADD expression was assessed on pretreatment tumor tissues of 248 cases of NPC patients and 76 cases of noncancerous nasopharyngeal control tissue. The results showed that the positive percentage of FADD expression in NPC (63.7%, 158/248) was significantly higher than that in the noncancerous nasopharyngeal control tissues (28.9%, 22/76) (P < .0001). The positive expression of FADD in the NPC with cervical lymph node metastasis was significantly higher than those without lymph node metastasis (P = .009). Furthermore, FADD expression was more pronouncedly increased in metastatic NPC than the matched primary NPC tissues (P = .017). Both univariate and multivariate survival analysis indicated that increased FADD expression was significantly correlated inversely with overall survival in NPC patients (P = .003 and P = .007, respectively). Taken together, high expression of FADD may be an independent biomarker for poor prognosis in NPC.
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Qiuyuan
authors.initials: Q
authors.lastname: Wen
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Weiyuan
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Jiadi
authors.initials: J
authors.lastname: Luo
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Shuzhou
authors.initials: S
authors.lastname: Chu
authors.affiliation: Department of Oncology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Guiyuan
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.affiliation: Department of Otorhinolaryngology, Xiangya Hospital of Central South University, Changsha, 410008, Hunan, China.
authors.forename: Donghai
authors.initials: D
authors.lastname: Huang
authors.affiliation: Department of Pathology, Basic Medical College of Central South University, Changsha, 410008, Hunan, China. Electronic address: lijinghe0718@126.com.
authors.forename: Jinghe
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pathology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China. Electronic address: fansongqing2003@hotmail.com.
authors.forename: Songqing
authors.initials: S
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D053200:Fas-Associated Death Domain Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein
keywords: Biomarker; Fatty acid synthase–associated protein with death domain (FADD); Immunohistochemistry; Nasopharyngeal carcinoma (NPC); Prognosis