title: Modeling the effect of intra-voxel diffusion of contrast agent on the quantitative analysis of dynamic contrast enhanced magnetic resonance imaging.
abstract: Quantitative dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) provides estimates of physiologically relevant parameters related to tissue blood flow, vascular permeability, and tissue volume fractions which can then be used for prognostic and diagnostic reasons. However, standard techniques for DCE-MRI analysis ignore intra-voxel diffusion, which may play an important role in contrast agent distribution and voxel signal intensity and, thus, will affect quantification of the aforementioned parameters. To investigate the effect of intra-voxel diffusion on quantitative DCE-MRI, we developed a finite element model of contrast enhancement at the voxel level. For diffusion in the range of that expected for gadolinium chelates in tissue (i.e., 1 × 10(-4) to 4 × 10(-4) mm(2)/s), parameterization errors range from -58% to 12% for K(trans), -9% to 8% for ve, and -60% to 213% for vp over the range of K(trans), v(e), v(p), and temporal resolutions investigated. Thus the results show that diffusion has a significant effect on parameterization using standard techniques.
authors.affiliation: Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Stephanie L
authors.initials: SL
authors.lastname: Barnes
authors.affiliation: Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: C Chad
authors.initials: CC
authors.lastname: Quarles
authors.affiliation: Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, United States of America; Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, United States of America; Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, United States of America; Program in Chemical and Physical Biology, Vanderbilt University, Nashville, Tennessee, United States of America.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Yankeelov
mesh_terms: D003287:Contrast Media; D004058:Diffusion; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008954:Models, Biological; D013997:Time Factors
chemical_list: D003287:Contrast Media