title: Radical based strategy toward the synthesis of 2,3-dihydrofurans from aryl ketones and aromatic olefins.
abstract: A copper-mediated annulation of aryl ketones with a wide range of aromatic olefins has been developed. This strategy allowed convenient access to 2,3-dihydrofuran derivatives. The versatility of the protocol is shown by synthesizing α-methyl dihydrofurans, which serve as an intermediate for the synthesis of vitamin B1. In addition, the applicability of the protocol in conjugated systems is demonstrated. A radical pathway was presumed and supported for annulation of aryl ketones with olefins.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Bombay , Powai, Mumbai 400076, India.
authors.forename: Togati
authors.initials: T
authors.lastname: Naveen
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kancherla
authors.forename: Debabrata
authors.initials: D
authors.lastname: Maiti
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013831:Thiamine / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000475:Alkenes; D005663:Furans; D007659:Ketones; C073812:2,3-dihydrofuran; D003300:Copper; D013831:Thiamine