title: Hypoglycemic effects of glycosaminoglycan from Urechis unicinctus in diabetic mice.
abstract: To further utilize glycosaminoglycan from Urechis unicinctus, the hypoglycemic effect and possible mechanism of glycosaminoglycan on diabetic mice were evaluated. Diabetes was induced in mice by intraperitoneal injections of streptozotocin for 3 consecutive days and fed with high-sugar and high-lipid fodder. After diabetes was confirmed, the hypoglycemic effect of glycosaminoglycan from U. unicinctus was investigated in the diabetic mice. Results demonstrated that glycosaminoglycan could significantly decrease blood glucose concentrations, HOMA-IR, AUG, and liver MDA content in diabetic mice. In addition, it significantly enhanced liver SOD and GSH-Px activity, as well as liver GCK activity and hepatic glycogen levels. Glycosaminoglycan from U. unicinctus exhibited efficacy against diabetes, suggesting its potential use as a natural intervention against diabetes.
authors.affiliation: Tianjin Key Laboratory for Marine Chemistry and Resources, College of Marine Science & Engineering, Tianjin University of Science and Technology , Tianjin, China .
authors.forename: Chunying
authors.initials: C
authors.lastname: Yuan
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.forename: Qingman
authors.initials: Q
authors.lastname: Cui
mesh_terms: D000818:Animals; D000845:Annelida / Q000737:chemistry*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005941:Glucokinase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D013311:Streptozocin; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D006025:Glycosaminoglycans; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; D008315:Malondialdehyde; D013311:Streptozocin; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005941:Glucokinase
keywords: Urechis unicinctus; diabetic mice; glycosaminoglycan; hypoglycemic effect