title: Can bariatric surgery improve cardiovascular risk factors in the metabolically healthy but morbidly obese patient?
abstract: BACKGROUND
  Bariatric surgery has been shown to be effective in resolving co-morbid conditions even in patients with a body mass index (BMI)<35 kg/m(2). A question arises regarding the metabolic benefits of bariatric surgery in metabolically healthy but morbidly obese (MHMO) patients, characterized by a low cardiometabolic risk. The objective of this study was to assess the effects of bariatric surgery on cardiometabolic risk factors among MHMO and metabolically unhealthy morbidly obese (MUMO) adults.
  
  
  METHODS
  A nonrandomized, prospective cohort study was conducted on 222 severely obese patients (BMI>40 kg/m(2)) undergoing either laparoscopic roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy. Patients were classified as MHMO if only 1 or no cardiometabolic factors were present: high blood pressure, triglycerides, blood glucose (or use of medication for any of these conditions), decreased high-density lipoprotein-cholesterol (HDL-C) levels, and insulin resistance defined as homeostasis model assessment for insulin-resistance (HOMA-IR)> 3.29.
  
  
  RESULTS
  Forty-two (18.9%) patients fulfilled the criteria for MHMO. They were younger and more frequently female than MUMO patients. No differences between groups were observed for weight, BMI, waist and hip circumference, total and LDL-C. MHMO patients showed a significant decrease in blood pressure, plasma glucose, HOMA-IR, total cholesterol, LDL-C and triglycerides and an increase in HDL-C 1 year after bariatric surgery. Weight loss 1 year after bariatric surgery was similar in both groups.
  
  
  CONCLUSIONS
  Eighteen percent of patients with morbid obesity fulfilled the criteria for MHMO. Although cardiovascular risk factors in these patients were within normal range, an improvement in all these factors was observed 1 year after bariatric surgery. Thus, from a metabolic point of view, MHMO patients benefited from bariatric surgery.
authors.affiliation: Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group (CARIN-ULEC), IMIM-Hospital del Mar Barcelona, Biomedical Research Park (Parc de Recerca Biomèdica de Barcelona - PRBB), Barcelona, Spain. Network of Centers for Biomedical Research (Centros de Investigación Biomédica en Red-CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos, III, Madrid, Spain; Departament de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain. Electronic address: Agoday@parcdesalutmar.cat.
authors.forename: Alberto
authors.initials: A
authors.lastname: Goday
authors.affiliation: Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group (CARIN-ULEC), IMIM-Hospital del Mar Barcelona, Biomedical Research Park (Parc de Recerca Biomèdica de Barcelona - PRBB), Barcelona, Spain. Network of Centers for Biomedical Research (Centros de Investigación Biomédica en Red-CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos, III, Madrid, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Benaiges
authors.affiliation: Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; Cardiovascular Risk and Nutrition Research Group (CARIN-ULEC), IMIM-Hospital del Mar Barcelona, Biomedical Research Park (Parc de Recerca Biomèdica de Barcelona - PRBB), Barcelona, Spain. Network of Centers for Biomedical Research (Centros de Investigación Biomédica en Red-CIBER), Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos, III, Madrid, Spain.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Parri
authors.affiliation: Unit of Gastrointestinal Surgery, Hospital del Mar, Institut de Recerca IMIM- Hospital del Mar, Barcelona, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Ramón
authors.affiliation: Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; Departament de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Juana A
authors.initials: JA
authors.lastname: Flores-Le Roux
authors.affiliation: Department of Endocrinology and Nutrition, Hospital del Mar, Barcelona, Spain; Departament de Medicina, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Pedro Botet
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000378:metabolism / Q000601:surgery*; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Bariatric surgery; Laparoscopic Roux-en-Y gastric bypass; Laparoscopic sleeve gastrectomy; Metabolically healthy but obese; Metabolically unhealthy but obese