title: Electrospun propolis/polyurethane composite nanofibers for biomedical applications.
abstract: Tissue engineering requires functional polymeric membrane for adequate space for cell migration and attachment within the nanostructure. Therefore, biocompatible propolis loaded polyurethane (propolis/PU) nanofibers were successfully prepared using electrospinning of propolis/PU blend solution. Here, composite nanofibers were subjected to detailed analysis using electron microscopy, FT-IR spectroscopy, thermal gravimetric analysis (TGA), and mechanical properties and water contact angle measurement. FE-SEM images revealed that the composite nanofibers became point-bonded with increasing amounts of propolis in the blend due to its adhesive properties. Incorporation of small amount of propolis through PU matrix could improve the hydrophilicity and mechanical strength of the fibrous membrane. In order to assay the cytocompatibility and cell behavior on the composite scaffolds, fibroblast cells were seeded on the matrix. Results suggest that the incorporation of propolis into PU fibers could increase its cell compatibility. Moreover, composite nanofibers have effective antibacterial activity. Therefore, as-synthesized nanocomposite fibrous mat has great potentiality in wound dressing and skin tissue engineering.
authors.affiliation: Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors.forename: Jeong In
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea; Department of Engineering Science and Humanities, Pulchowk Campus, Tribhuvan University, Kathmandu, Nepal; Research Institute for Next Generation, Kalanki, Kathmandu, Nepal. Electronic address: hempant@jbnu.ac.kr.
authors.forename: Hem Raj
authors.initials: HR
authors.lastname: Pant
authors.affiliation: Department of Bioactive Material Science, Research Center of Bioactive Material, Chonbuk National University, Jeonju, Chonbuk, Republic of Korea.
authors.forename: Hyun-Jaung
authors.initials: HJ
authors.lastname: Sim
authors.affiliation: Department of Molecular Biology, College of Natural Science, Chonbuk National University, Jeonju, 561-756, Republic of Korea.
authors.forename: Kang Min
authors.initials: KM
authors.lastname: Lee
authors.affiliation: Department of Bio-nano System Engineering, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors.forename: Cheol Sang
authors.initials: CS
authors.lastname: Kim
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D055595:Mechanical Phenomena; D051379:Mice; D008854:Microscopy, Electron; D053761:Nanocomposites / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011108:Polymers; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D011429:Propolis / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011108:Polymers; D011140:Polyurethanes; D011429:Propolis
keywords: Biomaterials; Electrospinning; Nanofibers; Polyurethane; Propolis