title: Effect of low-level laser therapy on radiotherapy-induced hyposalivation and xerostomia: a pilot study.
abstract: OBJECTIVE
  The present pilot study aimed to assess the effect of low-level laser therapy (LLLT) on hyposalivation and xerostomia as a consequence of head and neck radiotherapy.
  
  
  BACKGROUND
  The benefits of LLLT in salivary flow have been shown; however, there are no studies investigating its effects on patients who have already undergone radiotherapy and present hyposalivation and xerostomia as a sequela.
  
  
  METHODS
  Twenty-three patients with a history of head and neck malignancy, who were treated by fractioned teletherapy (dosimetry ranging from 45 to 70 Gy) in the cervicofacial region were selected. They all presented with xerostomia and severe hyposalivation. Patients were randomly distributed into a laser group (n=12) and a control group (n=11). A GaAlAs laser (830 nm, 100 mW, illuminated area 0.028 cm2, 3.57 W/cm2, 20 sec, 2.0 J, 71 J/cm2) was used punctually in the major salivary glands, twice a week for 6 weeks, with a 12 session total. Stimulated and unstimulated salivary flow rate (SFR) were assessed, as well as the xerostomia and quality of life related to oral health (QLROH).
  
  
  RESULTS
  The analysis did not show any significant difference between the groups with regards to the SFR and xerostomia, and the QLROH. However, at the end of the treatment, the xerostomia and the QLROH showed significant improvement in both groups compared with assessments performed at baseline, highlighting the importance of advice given to the irradiated patients, and their follow-up.
  
  
  CONCLUSIONS
  With the parameters used, LLLT was not able to increase SFR or decrease xerostomia. The results may be associated with the late effects of radiotherapy on glandular structure, such as fibrosis and acinar atrophy.
authors.affiliation: 1 Oral Medicine Division, São Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul- PUCRS , Porto Alegre - RS, Brazil .
authors.forename: Jamil
authors.initials: J
authors.lastname: Saleh
authors.forename: Maria Antonia Zancanaro
authors.initials: MA
authors.lastname: Figueiredo
authors.forename: Karen
authors.initials: K
authors.lastname: Cherubini
authors.forename: Aroldo
authors.initials: A
authors.lastname: Braga-Filho
authors.forename: Fernanda Gonçalves
authors.initials: FG
authors.lastname: Salum
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011832:Radiation Injuries / Q000209:etiology / Q000532:radiotherapy*; D012469:Salivary Glands / Q000528:radiation effects*; D012472:Salivation / Q000528:radiation effects*; D016896:Treatment Outcome; D014987:Xerostomia / Q000209:etiology / Q000532:radiotherapy*