title: Regulation of immune response by antibodies: the importance of antibody and monocyte Fc receptor interaction in T-cell activation.
abstract: The interaction between the Fc portions of antibodies and Fc receptors (FcR) on monocytes and macrophages is well known for such immune effector functions as the phagocytosis of antibody-coated bacterial and viral particles. Two additional functions of this Fc-FcR interaction have been described recently and both relate to the regulatory aspects of immune responses. These interactions, discussed here by Tse Wen Chang, are involved in antigen presentation, T cell activation and proliferation, and antibody production.
authors.affiliation: Centocor Inc., 244 Great Valley Parkway, Malvern, PA 19355, USA.
authors.forename: T W
authors.initials: TW
authors.lastname: Chang