title: Dural-based Rosai-Dorfman disease: differential diagnostic considerations.
abstract: Extranodal sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a non-neoplastic condition that has rarely been reported to involve the central nervous system. This report documents a 28-year-old man with Rosai-Dorfman disease who presented with a seizure and a dural-based mass that was thought to represent a meningioma. Resection showed a lesion marked by large, S-100 protein immunoreactive histiocytic cells with intermixed benign lymphocytes and plasma cells. Emperipolesis with intracytoplasmic lymphocytes and plasma cells was present. Differential diagnostic considerations will be discussed.
authors.affiliation: Cleveland Clinic, Department of Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: praysor@ccf.org.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.affiliation: Cleveland Clinic, Department of Pathology, L25, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: J Jordi
authors.initials: JJ
authors.lastname: Rowe
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000473:pathology*; D057687:Emperipolesis; D006644:Histiocytes / Q000473:pathology; D015614:Histiocytosis / Q000175:diagnosis; D015618:Histiocytosis, Sinus / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis; D008579:Meningioma / Q000175:diagnosis; D008581:Meningitis / Q000175:diagnosis; D008590:Meningoencephalitis / Q000175:diagnosis; D010950:Plasma Cells / Q000473:pathology; D009418:S100 Proteins / Q000032:analysis; D012507:Sarcoidosis / Q000175:diagnosis; D012640:Seizures / Q000209:etiology
chemical_list: D015415:Biomarkers; D009418:S100 Proteins
keywords: Brain tumor; Dural mass; Extranodal sinus histiocytosis with massive lymphadenopathy; Rosai–Dorfman disease