title: Methylprednisolone acetate-Eudragit® RS100 electrospuns: Preparation and physicochemical characterization.
abstract: The aim of the present study was to formulate methylprednisolone acetate -Eudragit(®) RS100 nanofibers and nanobeads by the electrospinning method. The physicochemical characteristics of the prepared electrospuns were assessed as well. The particle size and morphology were evaluated using scanning electron microscopy. The crystallinity of the drug in the nanofibers and nanobeads obtained was also studied by X-ray crystallography and differential scanning calorimetry (DSC) thermograms. In addition, FT-IR spectroscopy was applied to investigate any possible chemical interaction between the drug and carrier during the preparation process. The drug release kinetics were considered, to predict the release mechanism. Increasing the concentration of the injected solution resulted in the production of more nanofibers and less nanobeads, with the particle size ranging from 100 to 500 nm. The drug crystallinity was decreased during the electrospinning process; however, no interaction between drug and polymer was observed. The electrospuns showed faster drug release pattern compared to the pure drug. The release data were best fitted to the Weibull model, in which the corresponding shape factor values of the model were less than 0.75 indicating the diffusion mechanism of drug release. In conclusion, electrospinning could be considered as a simple and cost effective method for fabricating the drug: polymer nanofibers and nanobeads.
authors.affiliation: a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Nazila
authors.initials: N
authors.lastname: Jafari-Aghdam
authors.affiliation: a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Khosro
authors.initials: K
authors.lastname: Adibkia
authors.affiliation: a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.|b Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Payab
authors.affiliation: a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Barzegar-Jalali
authors.affiliation: a Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Parvizpur
authors.affiliation: c Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences , Kermanshah , Iran.
authors.forename: Ghobad
authors.initials: G
authors.lastname: Mohammadi
authors.affiliation: d Department of Pharmaceutics , Faculty of Pharmacy, Tehran University of Medical Sciences , Tehran , Iran.
authors.forename: Araz
authors.initials: A
authors.lastname: Sabzevari
mesh_terms: D055598:Chemical Phenomena; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D004560:Electricity; D007700:Kinetics; D008775:Methylprednisolone / Q000031:analogs & derivatives* / Q000737:chemistry; D000077555:Methylprednisolone Acetate; D057139:Nanofibers / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D000077555:Methylprednisolone Acetate; D008775:Methylprednisolone
keywords: Eudragit® RS100; electrospinning; methylprednisolone acetate; nanobeads; nanofibers; physicochemical characteristics