title: Thrombophilic risk factors are uncommon in young patients with retinal vein occlusion.
abstract: OBJECTIVE
  To study the thrombotic factors, namely deficiencies of plasma proteins C, S, and antithrombin, factor V Leiden mutation, and positivity for antiphospholipid antibodies in young patients with retinal vein occlusion.
  
  
  METHODS
  The thrombophilia parameters listed above were analyzed from the laboratory records of 50 patients with the clinical diagnosis of retinal vein occlusion, aged less than 50 years.
  
  
  RESULTS
  A single prothrombotic factor was seen in 2 (4%) cases. The highest positivity was for the antiphospholipid antibodies (lupus anticoagulant in 6%, anticardiolipin antibodies in 2%, and anti-β 2 glycoprotein 1 in 10% cases). Other than one case where antiphospholipid syndrome was confirmed, these were transient. One patient had antithrombin deficiency. Protein C and protein S deficiency and factor V Leiden mutation were not seen in this group.
  
  
  CONCLUSIONS
  Our data suggest that these thrombophilia risk factors are not commonly associated with retinal vein occlusion, and there is a need for studies on other factors that contribute to the development of this condition.
authors.affiliation: Departments of *Hematology and †Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India; and ‡Department of Ophthalmology, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Ahluwalia
authors.forename: Sandeep
authors.initials: S
authors.lastname: Rao
authors.forename: Subhash
authors.initials: S
authors.lastname: Varma
authors.forename: Amod
authors.initials: A
authors.lastname: Gupta
authors.forename: Sunil
authors.initials: S
authors.lastname: Bose
authors.forename: Joseph
authors.initials: J
authors.lastname: Masih
authors.forename: Reena
authors.initials: R
authors.lastname: Das
authors.forename: Narender
authors.initials: N
authors.lastname: Kumar
authors.forename: Shano
authors.initials: S
authors.lastname: Naseem
authors.forename: Prashant
authors.initials: P
authors.lastname: Sharma
authors.forename: Man Updesh Singh
authors.initials: MU
authors.lastname: Sachdeva
authors.forename: Neelam
authors.initials: N
authors.lastname: Varma
mesh_terms: D000293:Adolescent; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D012170:Retinal Vein Occlusion / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000150:complications*
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D011486:Protein C; D017293:Protein S; C095381:factor V Leiden; D005165:Factor V