title: Comparative LC-MS-based metabolite profiling of the ancient tropical rainforest tree Symphonia globulifera.
abstract: In the last few years, several phytochemical studies have been undertaken on the tropical tree Symphonia globulifera leading to the isolation and characterisation of several compounds exhibiting antiparasitic activities against Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani. The comparative LC-MS based metabolite profiling study conducted on the tree led to the identification of compounds originating from specific tissues. The results showed that renewable organs/tissues can be used as the starting material for the production of polycyclic poly-prenylated-acylphloroglucinols, therefore reducing impacts on biodiversity. This study also underlined the lack of knowledge on the secondary metabolites produced by S. globulifera since only a small number of the total detected features were putatively identified using the database of known compounds for the species.
authors.affiliation: Laboratoire de Pharmacognosie, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Kévin
authors.initials: K
authors.lastname: Cottet
authors.affiliation: Laboratoire de Pharmacognosie, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France. Electronic address: gregory.genta-jouve@parisdescartes.fr.
authors.forename: Grégory
authors.initials: G
authors.lastname: Genta-Jouve
authors.affiliation: Laboratoire de Pharmacognosie, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Yann
authors.initials: Y
authors.lastname: Fromentin
authors.affiliation: CNRS Guyane, USR3456, 2 Avenue Gustave Charlery, 97300 Cayenne, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Odonne
authors.affiliation: CNRS-UMR 8172 ECOFOG, Institut Pasteur de la Guyane, 23 Avenue Pasteur, 97306 Cayenne, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Duplais
authors.affiliation: Laboratoire de Chimie et Toxicologie Analytique et Cellulaire, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Laprévote
authors.affiliation: Laboratoire de Pharmacognosie, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Michel
authors.affiliation: Laboratoire de Pharmacognosie, UMR 8638, Université Paris Descartes Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Lallemand
mesh_terms: D001577:Benzophenones / Q000737:chemistry; D028084:Clusiaceae / Q000737:chemistry*; D016208:Databases, Factual; D035264:Flowers / Q000737:chemistry; D005616:French Guiana; D055432:Metabolomics; D015394:Molecular Structure; D024301:Plant Bark / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D065947:Rainforest; D012639:Seeds / Q000737:chemistry; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D044004:Xanthones / Q000737:chemistry
chemical_list: D001577:Benzophenones; D044004:Xanthones; C508575:gaboxanthone; C558133:guttiferone A
keywords: Kendrick mass defect; LC–MS; Plant organs; Symphonia globulifera; Untargeted metabolomics