title: Circadian rest/activity rhythms in knee osteoarthritis with insomnia: a study of osteoarthritis patients and pain-free controls with insomnia or normal sleep.
abstract: Aberrant circadian rest/activity rhythms (RARs) may promote poor aging-related health outcomes. Osteoarthritis and chronic insomnia are common age-related conditions, but the circadian RARs of each group have not been well characterized or compared. We evaluated actigraphic RARs in individuals with: (1) knee osteoarthritis (KOA) only; (2) chronic insomnia only; (3) KOA + insomnia; and (4) pain-free good sleepers. Compared to participants with KOA only, those with KOA + insomnia had less robust RARs. There were no differences between other groups. Further research is needed to evaluate whether aberrant RARs contribute to arthritis symptoms and insomnia in KOA, and whether strengthening RARs ameliorates arthritis symptoms.
authors.affiliation: Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD , USA .
authors.forename: Adam P
authors.initials: AP
authors.lastname: Spira
authors.forename: Virginia T
authors.initials: VT
authors.lastname: Runko
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Finan
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Kaufmann
authors.forename: Sara C
authors.initials: SC
authors.lastname: Bounds
authors.forename: Lianqi
authors.initials: L
authors.lastname: Liu
authors.forename: Luis F
authors.initials: LF
authors.lastname: Buenaver
authors.forename: Lea M
authors.initials: LM
authors.lastname: McCauley
authors.forename: Sonia
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: Michael T
authors.initials: MT
authors.lastname: Smith
mesh_terms: D056044:Actigraphy; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D002940:Circadian Rhythm; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000150:complications / Q000503:physiopathology*; D010146:Pain; D059408:Pain Management; D012146:Rest; D012890:Sleep; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications / Q000503:physiopathology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
keywords: Actigraphy; activity; aging; pain; sleep