title: Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme.
abstract: The use of proteinases as targets to develop novel chemotherapies against Leishmania spp. infections is a very promising strategy. Based on a previous study by Goyal et al. [J Mol Model (2014) 20:2099], we discuss herein the idea that only a combined treatment with distinct proteinase inhibitors would be an effective antileishmanial therapy.
authors.affiliation: Fundação Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Instituto Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, CEP 21040-360, Brazil, calves@ioc.fiocruz.br.
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Alves
authors.forename: Bernardo Acácio Santini
authors.initials: BA
authors.lastname: Pereira
authors.forename: Mariana
authors.initials: M
authors.lastname: Silva-Almeida
authors.forename: Franklin Souza
authors.initials: FS
authors.lastname: da Silva
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D007891:Leishmania / Q000145:classification / Q000187:drug effects* / Q000201:enzymology; D015394:Molecular Structure; D058990:Molecular Targeted Therapy; D010447:Peptide Hydrolases / Q000737:chemistry / Q000378:metabolism; D011480:Protease Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011487:Protein Conformation; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000981:Antiprotozoal Agents; D011480:Protease Inhibitors; D015800:Protozoan Proteins; D010447:Peptide Hydrolases