title: The design and performance of a portable handheld (11)CO2 delivery system.
abstract: We constructed a hand-held device to efficiently trap [(11)C]CO2 from the cyclotron target, safely transport up to 3.7GBq (100mCi) doses to remote sites and release it without the need for a liquid cryogen. The system consists of a 180W furnace and a miniature molecular sieve trap (80-100mg; 80-100mesh 13×) placed inside a lead pig weighing 11.1kg. The overall [(11)C]CO2 delivery efficiency of the device is ~82% (> 99% trapping efficiency). Radiation dose rates measured at 30cm from the surface of the pig are <43.5µSv/h (5mR/h) up to 2.59GBq (70mCi).
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: dohkim@bnl.gov.
authors.forename: Dohyun
authors.initials: D
authors.lastname: Kim
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: alexoff@bnl.gov.
authors.forename: David L
authors.initials: DL
authors.lastname: Alexoff
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: mschueller@bnl.gov.
authors.forename: Mike
authors.initials: M
authors.lastname: Schueller
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: bbabst@bnl.gov.
authors.forename: Ben
authors.initials: B
authors.lastname: Babst
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: ferrieri@bnl.gov.
authors.forename: Richard
authors.initials: R
authors.lastname: Ferrieri
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: fowler@bnl.gov.
authors.forename: Joanna S
authors.initials: JS
authors.lastname: Fowler
authors.affiliation: Biosciences Department, Brookhaven National Laboratory, Upton, NY 11973-5000, USA. Electronic address: schlyer@bnl.gov.
authors.forename: David J
authors.initials: DJ
authors.lastname: Schlyer
mesh_terms: D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000737:chemistry* / Q000302:isolation & purification; D002250:Carbon Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006361:Heating / Q000295:instrumentation*; D008904:Miniaturization; D011835:Radiation Protection / Q000295:instrumentation*; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification; D012212:Rheology / Q000295:instrumentation*; D013048:Specimen Handling / Q000295:instrumentation*
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D002245:Carbon Dioxide
keywords: Miniature; PET; Portable; Radiochemistry; [(11)C]CO(2)