title: Clonal diversity and drug resistance in Mycobacterium tuberculosis isolated from extra-pulmonary samples in central India--a pilot study.
abstract: In India, extrapulmonary tuberculosis (EPTB) accounts for 10 - 15% of all types of tuberculosis. To identify and compare predominant spoligotypes and drug-resistance patterns in strains of Mycobacterium tuberculosis isolated from extrapulmonary and pulmonary specimens in central India, drug susceptibility testing and spoligotyping were carried out. Spoligotyping data was analyzed using SITVIT2 database. ST11/EAI3_Ind with 33% isolates among extrapulmonary specimens and ST26/CAS1_DEL with 28% isolates among pulmonary specimens were the most predominant lineages. Multidrug resistance was found in 5.5% of the strains isolated from extrapulmonary specimens in contrast to 17% isolated from pulmonary specimens.
authors.affiliation: Department of Microbiology, Bhopal Memorial Hospital and Research Centre, Indian Council of Medical Research, Karond, Bhopal, Madhya Pradesh, India.
authors.forename: P
authors.initials: P
authors.lastname: Desikan
authors.forename: D S
authors.initials: DS
authors.lastname: Chauhan
authors.forename: P
authors.initials: P
authors.lastname: Sharma
authors.forename: N
authors.initials: N
authors.lastname: Panwalkar
authors.forename: P
authors.initials: P
authors.lastname: Yadav
authors.forename: B S
authors.initials: BS
authors.lastname: Ohri
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology*; D016000:Cluster Analysis; D024881:Drug Resistance, Bacterial; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D058889:Molecular Typing; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D014376:Tuberculosis / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents