title: [Experimental evaluation of efficiency of bioprophylactic complex aimed at reduction of toxic effects caused by copper oxide nanoparticles].
abstract: In subchronic intoxication via repeated intraperitoneal injection of copper oxide nanoparticles (diameter 20 nm, 19 times in dose of 10 mg/kg of rats, 3 times per week), findings are that oral intake of bioprotectors complex (pectine, polyvitamin and polymineral preparation, sodium glutaminate, glycine, acetylcysteine and fish oil preparation with high content of unsaturated fatty acids of omega-3 group) decreases copper accumulation in viscera (including statistically significantly in spleen) and slows development of pathologic changes in liver, brain and kidneys. With that, genotoxic effect of nanocopper also decreases--according to lower fragmentation of genome DNA in liver and spleen cells.
authors.forename: N V
authors.initials: NV
authors.lastname: Loginova
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003300:Copper / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D053938:DNA Fragmentation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D018384:Oxidative Stress / Q000187:drug effects; D010316:Particle Size; D020011:Protective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013499:Surface Properties; D013997:Time Factors
chemical_list: D004785:Environmental Pollutants; D020011:Protective Agents; D003300:Copper; C030973:cupric oxide