title: Congenital fulminant Kaposiform hemangioendothelioma of the leg.
abstract: Kaposiform hemangioendothelioma is a rare locally aggressive vascular tumor associated with Kasabach Merritt syndrome. We present a case of congenital Kaposiform hemangioendothelioma of the leg in a female infant who was born to a mother treated with various medications including etanercept, a TNF antagonist, due to rheumatoid arthritis. The neonate suffered from a fulminant form of Kasabach Merritt syndrome with disseminated intravascular coagulation (DIC) resulting in multi-organ failure which led to her demise.
authors.affiliation: Department of Neonatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel. Electronic address: zivanit@hadassah.org.il.
authors.forename: Zivanit
authors.initials: Z
authors.lastname: Ergaz
authors.affiliation: Department of Neonatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bar-Oz
authors.affiliation: Department of Pathology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Gilad W
authors.initials: GW
authors.lastname: Vainer
authors.affiliation: Department of Neonatology, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Sinan
authors.initials: S
authors.lastname: Abu-Leil
authors.affiliation: Department of Medical Imaging, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
authors.forename: Natalia
authors.initials: N
authors.lastname: Simanovsky
authors.affiliation: The Israeli Teratology Information Service, Israel Ministry of Health, Jerusalem, Israel.
authors.forename: Orna
authors.initials: O
authors.lastname: Diav-Citrin
mesh_terms: D005260:Female; D006390:Hemangioendothelioma / Q000151:congenital* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D059885:Kasabach-Merritt Syndrome / Q000151:congenital* / Q000473:pathology; D007866:Leg; D012514:Sarcoma, Kaposi / Q000151:congenital* / Q000473:pathology
keywords: Congenital; Etanercept; Kaposiform hemangioendothelioma; Kasabach Merritt syndrome; Multi-organ failure