title: Dietary D-sorbose decreases serum insulin levels in growing Sprague-Dawley rats.
abstract: D-Sorbose is naturally occurring rare sugar. In this study, we examined the effects of dietary D-sorbose in rats. Four-week-old male Sprague-Dawley rats were fed either an AIN-93G-based control diet or a 3% D-sorbose diet for 28 d. Body weight and body fat accumulation were not different between the two diet groups. Dietary supplementation of D-sorbose lowered the serum insulin level (*p<0.05) significantly compared to the control, although the glucose was not changed. In addition, the relative weight of the cecum increased significantly in the D-sorbose group (**p<0.01). These findings suggest that intake of D-sorbose may improve the glucose metabolism by reducing insulin secretion, and D-sorbose can be used as a food ingredient.
authors.affiliation: Research and Development, Matsutani Chemical Industry Co., Ltd.
authors.forename: Takako
authors.initials: T
authors.lastname: Yamada
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Iida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamine
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okuma
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Matsuo
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000187:drug effects; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D019587:Dietary Supplements; D007328:Insulin / Q000097:blood*; D008297:Male; D009929:Organ Size; D017207:Rats, Sprague-Dawley; D013013:Sorbose / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D013013:Sorbose