title: Effect of Wnt inhibitors in pancreatic cancer.
abstract: OBJECTIVE
  Activated Wnt signaling in cancer cells leads to cell proliferation. It has been shown that the Wnt pathway is activated in pancreatic adenocarcinoma cells. Therefore, we tested the effect of Wnt inhibitors in human and murine pancreatic cancer cell lines.
  
  
  METHODS
  The Wnt inhibitors ethacrynic acid (EA), ciclopirox olamine (CIC), piroctone olamine (PO) and griseofulvin (GF) were tested in murine and human pancreatic cancer cell lines with the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay.
  
  
  RESULTS
  We showed that the Wnt inhibitors significantly reduced cell viability in murine, as well as human pancreatic cancer cell lines.
  
  
  CONCLUSIONS
  These results may lead to a new therapeutic option with Wnt inhibitors for patients with pancreatic adenocarcinoma.
authors.affiliation: Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Universitätsklinikum Bonn, Bonn, Germany.
authors.forename: Ilona
authors.initials: I
authors.lastname: Wall
authors.affiliation: Center for Integrated Oncology (CIO), Med. Klinik und Poliklinik III, Universitätsklinikum Bonn, Bonn, Germany Ingo.Schmidt-Wolf@ukb.uni-bonn.de.
authors.forename: Ingo G H
authors.initials: IG
authors.lastname: Schmidt-Wolf
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D000077768:Ciclopirox; D004338:Drug Combinations; D004976:Ethacrynic Acid / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology; D006118:Griseofulvin / Q000494:pharmacology; D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D011728:Pyridones / Q000494:pharmacology; D051153:Wnt Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D004983:Ethanolamines; D011728:Pyridones; D051153:Wnt Proteins; D000077768:Ciclopirox; D006118:Griseofulvin; C052599:piroctone olamine; D004976:Ethacrynic Acid
keywords: Wnt pathway; gastrointestinal tumors; pancreatic cancer