title: Role of sublingual misoprostol for cervical priming in first trimester medical termination of pregnancy.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of sublingual misoprostol as facilitator in first trimester medical termination of pregnancy (MTP) by surgical method.
  
  
  METHODS
  This was a prospective open label study conducted at a tertiary center. A total 150 patients at 6-12 wks gestation requesting for MTP were randomized into two groups. Patients in study group (n=75) received sublingual misoprostol three hours before surgical abortion and in control group (n=75) directly underwent surgical abortion without prior cervical priming with misoprostol. The outcomes of both groups were recorded in terms of baseline cervical dilatation, need of additional cervical dilatation, intraoperative blood loss, operative time and procedure related complications. The results were statistically analyzed using student-t test and chi-square test. p-value of <0.05 and <0.001 were considered significant and highly significant respectively.
  
  
  RESULTS
  The mean baseline cervical dilatation was significantly more in study group compared to control group (8.6±1.3mm versus 5±2.3mm; p <0.001) and the operative time and intraoperative blood loss were also less (p<0.001). Higher incidence of side effects like nausea, vomiting and pyrexia were recorded in sublingual misoprostol group but were well tolerable to the patients.
  
  
  CONCLUSIONS
  Sublingual misoprostol is an effective and safe drug for cervical priming prior to surgical evacuation and has good patient acceptability.
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, Government Medical College & Hospital , Sector-32, Chandigarh, India .
authors.forename: Megha
authors.initials: M
authors.lastname: Mathur
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, Government Medical College & Hospital , Sector-32, Chandigarh, India .
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Rani
authors.affiliation: Ex-Professor & Head, Department of Obstetrics and Gynaecology, Sardar Patel Medical College , Bikaner, Rajasthan, India .
authors.lastname: Vijayshree
keywords: Baseline cervical dilatation; Cervical priming; Misoprostol; Surgical Abortion