title: Caffeic acid derivatives, analogs and applications: a patent review (2009-2013).
abstract: BACKGROUND
  Caffeic acid (CA) is broadly distributed in several species of the plant kingdom and is widely consumed in human diet. CA and derivatives have been extensively studied in the past years, which unveiled a broad spectrum of biological activities and potential therapeutic applications. As a result, there has been an upsurge in the development of new chemical entities based on the CA scaffold.
  
  
  METHODS
  The scope of this review is to revisit the therapeutic potential of CA and derivatives. It provides an overview of patented processes and applications thereof between 2009 and 2013.
  
  
  CONCLUSIONS
  The phenylpropanoid framework is currently considered a valid structure for drug discovery programs. Actually, CA has been widely used as a template for the development of new chemical entities with potential therapeutic interest in human diseases associated with oxidative stress. Additionally, the applicability of CA derivatives expands to the realms of cosmetic industry due to its stabilizing properties. The synthesis of esters, amides and hybrids with currently marketed drugs is a trending strategy for the development of derivatives with therapeutic application. It is our opinion that the innovative artwork currently being developed involving this chemical scaffold will yield new and effective therapeutic agents in a foreseeable future.
authors.affiliation: University of Porto, CIQ/Department of Chemistry and Biochemistry, Faculty of Sciences , Rua do Campo Alegre s/n, Porto , Portugal fborges@fc.up.pt.
authors.forename: Tiago
authors.initials: T
authors.lastname: Silva
authors.forename: Catarina
authors.initials: C
authors.lastname: Oliveira
authors.forename: Fernanda
authors.initials: F
authors.lastname: Borges
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002109:Caffeic Acids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D003358:Cosmetics; D005503:Food Additives; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D010330:Patents as Topic
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D000975:Antioxidants; D002109:Caffeic Acids; D003358:Cosmetics; D005503:Food Additives; D018696:Neuroprotective Agents; C040048:caffeic acid
keywords: caffeic acid and derivatives; hydroxycinnamic acids; multi-target-directed drugs; therapeutic patents