title: Association and interaction analysis of PPARGC1A and serum uric acid on type 2 diabetes mellitus in Chinese Han population.
abstract: BACKGROUND
  Peroxisome proliferator-activated receptor gamma coactivator-1α (PPARGC1A/ PGC-1α) is a ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. The activity of PGC-1α or genetic variations in the gene encoding the enzyme may contribute to individual variations in mitochondrial function and insulin resistance or diabetes. The objective of this study was to assess the extent to which PPARGC1A (rs8192678) and serum uric acid (UA) and its interaction impact on T2DM susceptibility in Chinese Han population.
  
  
  METHODS
  We conducted a study in a cohort that included 1166 T2DM patients and 1135 controls, and was genotyped for the presence of the PPARGC1A rs8192678 polymorphisms. Genotyping was performed by iPLEX technology. The association between rs8192678 or UA and T2DM was assessed by univariate and multivariate logistic regression (MLR) analysis controlling for confounders. The interaction between rs8192678 and UA for T2DM susceptibility was also assessed by MLR analysis.
  
  
  RESULTS
  The generalized linear regression analysis failed to show an association between the PPARGC1A rs8192678 polymorphisms and T2DM. Interestingly, the present study provided data suggesting that the minor A-allele of PPARGC1A (rs8192678) had a protective effect against T2DM in subjects with higher level of UA (ORint =1.50 95% CI: 1.06-2.12 for allele and P = 0.02, ORint =1.63 95% CI: 1.17-2.26 for genotype and P = 0.004).
  
  
  CONCLUSIONS
  The combination of higher level of UA and PPARGC1A (rs8192678) was an independent predictor for T2DM.
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Wu
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Nai-Jia
authors.initials: NJ
authors.lastname: Liu
authors.affiliation: Department of Endocrinology and Metabolism, Xin Hua Hospital, Shanghai Jiao Tong University, Shanghai, 200020 China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.affiliation: Department of Endocrinology and Metabolism, Hua Dong Hospital, Fudan University, Shanghai, 200040 China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Tao
authors.affiliation: Department of Endocrinology and Metabolism, Hua Dong Hospital, Fudan University, Shanghai, 200040 China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Du
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Xuan-Chun
authors.initials: XC
authors.lastname: Wang
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Bin
authors.initials: B
authors.lastname: Lu
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Zhao-Yun
authors.initials: ZY
authors.lastname: Zhang
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China.
authors.forename: Ren-Ming
authors.initials: RM
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, NO. 12 Wulumuqi Mid Road, Building 0#, Jing'an District, Shanghai 200040 China ; Department of Endocrinology and Metabolism, Jing'an District Center Hospital of Shanghai, Shanghai, 200040 China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wen
keywords: Chinese Han population; Interaction; PPARGC1A; Serum uric acid; Type 2 diabetes mellitus