title: Missing pieces of an ancient puzzle: evolution of the eukaryotic membrane-trafficking system.
abstract: The membrane-trafficking system underpins cellular trafficking of material in eukaryotes and its evolution would have been a watershed in eukaryogenesis. Evolutionary cell biological studies have been unraveling the history of proteins responsible for vesicle transport and organelle identity revealing both highly conserved components and lineage-specific innovations. Recently, endomembrane components with a broad, but patchy, distribution have been observed as well, pieces that are missing from our cell biological and evolutionary models of membrane trafficking. These data together allow for new insights into the history and forces that shape the evolution of this critical cell biological system.
authors.affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Schlacht
authors.affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
authors.forename: Emily K
authors.initials: EK
authors.lastname: Herman
authors.affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Klute
authors.affiliation: Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom.
authors.forename: Mark C
authors.initials: MC
authors.lastname: Field
authors.affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
authors.forename: Joel B
authors.initials: JB
authors.lastname: Dacks
mesh_terms: D001692:Biological Transport / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D019143:Evolution, Molecular; D026901:Membrane Transport Proteins / Q000502:physiology; D008954:Models, Biological
chemical_list: D026901:Membrane Transport Proteins