title: Cerenkov imaging.
abstract: Cerenkov luminescence (CL) has been used recently in a plethora of medical applications like imaging and therapy with clinically relevant medical isotopes. The range of medical isotopes used is fairly large and expanding. The generation of in vivo light is useful since it circumvents depth limitations for excitation light. Cerenkov luminescence imaging (CLI) is much cheaper in terms of infrastructure than positron emission tomography (PET) and is particularly useful for imaging of superficial structures. Imaging can basically be done using a sensitive camera optimized for low-light conditions, and it has a better resolution than any other nuclear imaging modality. CLI has been shown to effectively diagnose disease with regularly used PET isotope ((18)F-FDG) in clinical setting. Cerenkov luminescence tomography, Cerenkov luminescence endoscopy, and intraoperative Cerenkov imaging have also been explored with positive conclusions expanding the current range of applications. Cerenkov has also been used to improve PET imaging resolution since the source of both is the radioisotope being used. Smart imaging agents have been designed based on modulation of the Cerenkov signal using small molecules and nanoparticles giving better insight of the tumor biology.
authors.affiliation: Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Sudeep
authors.initials: S
authors.lastname: Das
authors.affiliation: Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
authors.forename: Daniel L J
authors.initials: DL
authors.lastname: Thorek
authors.affiliation: Molecular Pharmacology and Chemistry Program and Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: grimmj@mskcc.org.
authors.forename: Jan
authors.initials: J
authors.lastname: Grimm
mesh_terms: D000818:Animals; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008163:Luminescent Measurements / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: Activatable; Cancer biology; Cerenkov luminescence; Clinical; Endoscopy; Fluorescence; Imaging; In vivo light; Intraoperative; Low-light camera; Nanoparticle; Positron emission; Quenching; SCIFI; Smart; Tomography