title: [Association between interleukin-6 polymorphism in the -174 G/C region and hearing loss in the elderly with a history of occupational noise exposure].
abstract: BACKGROUND
  The biological processes involved in noise-induced hearing loss (NIHL) are still unclear. The involvement of inflammation in this condition has been suggested.
  
  
  OBJECTIVE
  To investigate the association between interleukin - 6 (IL-6) polymorphism and susceptibility to NIHL.
  
  
  METHODS
  This was a cross-sectional study with a sample of 191 independent elderly individuals aged >60 years of age. Information on exposure to occupational noise was obtained by interviews. Audiological evaluation was performed using pure tone audiometry and genotyped through PCR by restriction fragment length polymorphism - PCR-RFLP. Data were analyzed using the chi-square test and the odds ratio (OR), with the significance level set at 5%.
  
  
  RESULTS
  Among elderly with hearing loss (78.0%), 18.8% had a history of exposure to occupational noise. There was a statistically significant association between the genotype frequencies of the IL-6 -174 and NIHL. The elderly with the CC genotype were less likely to have hearing loss due to occupational noise exposure when compared to those carrying the GG genotype (OR=0.0124; 95% CI 0.0023-0.0671; p<0.001).
  
  
  CONCLUSIONS
  This study suggests there is an association of polymorphisms in the IL-6 gene at position - G174C with susceptibility to noise-induced hearing loss.
authors.affiliation: Universidade Norte do Paraná (UNOPAR), Londrina, PR, Brazil.
authors.forename: Miula Portelinha
authors.initials: MP
authors.lastname: Braga
authors.affiliation: University of London, London, United Kingdom; Department of Pediatric Dentistry, Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil.
authors.forename: Sandra Mara
authors.initials: SM
authors.lastname: Maciel
authors.affiliation: Universidade Estadual de Londrina (UEL), Londrina, PR, Brazil; Universidade Norte do Paraná (UNOPAR), Londrina, PR, Brazil. Electronic address: luciana.marchiori@unopar.br.
authors.forename: Luciana Lozza de Moraes
authors.initials: LL
authors.lastname: Marchiori
authors.affiliation: Universidade Norte do Paraná (UNOPAR), Londrina, PR, Brazil; Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP), Botucatu, PR, Brazil.
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: Poli-Frederico
mesh_terms: D000368:Aged; D001301:Audiometry, Pure-Tone; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006317:Hearing Loss, Noise-Induced / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D015850:Interleukin-6
keywords: Citocinas; Cytokines; Occupational noise; Perda auditiva neurossensorial; Ruído ocupacional; Sensorineural hearing loss