title: Platelets: still a therapeutical target for haemostatic disorders.
abstract: Platelets are cytoplasmatic fragments from bone marrow megakaryocytes present in blood. In this work, we review the basis of platelet mechanisms, their participation in syndromes and in arterial thrombosis, and their potential as a target for designing new antithrombotic agents. The option of new biotechnological sources is also explored.
authors.affiliation: Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói CEP 24210-130, RJ, Brazil. reinaldobgeraldo@yahoo.com.br.
authors.forename: Reinaldo Barros
authors.initials: RB
authors.lastname: Geraldo
authors.affiliation: Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil. pliniocs@yahoo.com.br.
authors.forename: Plínio Cunha
authors.initials: PC
authors.lastname: Sathler
authors.affiliation: Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil. andrebiouff@gmail.com.
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Lourenço
authors.affiliation: Programa de Pós-graduação em Patologia, Departamento de Patologia, Hospital Universitário Antônio Pedro (HUAP), Universidade Federal Fluminense (UFF), Niterói CEP 24030-215, RJ, Brazil. maxs@yahoo.com.br.
authors.forename: Max Seidy
authors.initials: MS
authors.lastname: Saito
authors.affiliation: LabTIF, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro CEP 21941-590, RJ, Brazil. pliniocs@yahoo.com.br.
authors.forename: Lucio M
authors.initials: LM
authors.lastname: Cabral
authors.affiliation: Interdisciplinary Center for Biotechnology Research, Federal University of Pampa, Antônio Trilha Avenue, P.O. Box 1847, São Gabriel/RS 97300-000, Brazil. pabulo@lacesm.ufsm.br.
authors.forename: Pabulo Henrique
authors.initials: PH
authors.lastname: Rampelotto
authors.affiliation: Programa de Pós-graduação em Ciências e Biotecnologia, Instituto de Biologia, Universidade Federal Fluminense (UFF), Niterói CEP 24210-130, RJ, Brazil. hcastrorangel@yahoo.com.br.
authors.forename: Helena Carla
authors.initials: HC
authors.lastname: Castro
mesh_terms: D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D020141:Hemostatic Disorders / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D010981:Platelet Storage Pool Deficiency / Q000378:metabolism / Q000473:pathology; D013927:Thrombosis / Q000188:drug therapy / Q000473:pathology
chemical_list: D016023:Integrins; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin