title: Clinical manifestations and longterm outcome for patients with Takayasu arteritis in China.
abstract: OBJECTIVE
  To describe a large cohort of patients with Takayasu arteritis in China.
  
  
  METHODS
  We retrospectively analyzed 566 patients hospitalized in Fuwai Hospital between 2002 and 2013. Data collected were clinical characteristics, laboratory findings, angiographic features, treatment, and longterm outcome.
  
  
  RESULTS
  The female to male ratio was 3.8 to 1, and the mean age of onset was 28.9 ± 12.0 years. The most common inflammatory symptom, initial symptom, and coexisting disease were fever (52, 9.2%), dizziness (214, 37.8%), and hypertension (HTN; 392, 69.3%), respectively. Pulmonary artery, coronary artery involvement, and aortic regurgitation were found in 83 (14.7%), 66 (11.7%), and 181 (36.7%) patients, respectively. Elevation of the erythrocyte sedimentation rate was observed in 131 patients (23.1%). Treatment included drugs, interventional therapy, autologous blood vessel transplant, artificial blood vessel transplant, and aortic valve replacement. During a mean followup of 5.0 ± 0.2 years, 32 patients died, including 1 patient who died suddenly during coronary angiography. HTN, major complications, and a progressive disease course were significant prognostic markers.
  
  
  CONCLUSIONS
  HTN, rather than fever, is the leading reason for patients with Takayasu arteritis to see a doctor in China. HTN, major complications, and a progressive disease course are statistically significant predictors of survival. Because of cardiovascular events associated with the disease, early diagnosis and treatment are urgent to improve prognosis.
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Lirui
authors.initials: L
authors.lastname: Yang
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College. zhanghuimin@medmail.com.cn jiangxiongjing@163.com.
authors.forename: Huimin
authors.initials: H
authors.lastname: Zhang
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Xiongjing
authors.initials: X
authors.lastname: Jiang
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Yubao
authors.initials: Y
authors.lastname: Zou
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Fang
authors.initials: F
authors.lastname: Qin
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Lei
authors.initials: L
authors.lastname: Song
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Ting
authors.initials: T
authors.lastname: Guan
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Haiying
authors.initials: H
authors.lastname: Wu
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Lianjun
authors.initials: L
authors.lastname: Xu
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Yaxin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zhou
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Jin
authors.initials: J
authors.lastname: Bian
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
authors.affiliation: From the Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.L. Yang, MD, PhD; H. Zhang, MD; X. Jiang, MD; Y. Zou, MD, PhD; F. Qin, MD; Y. Liu, MD, PhD; H. Wu, MD; L. Song, MD, PhD; L. Xu, MD, PhD; T. Guan, MD; X. Zhou, MD, PhD; J. Bian, MD; R. Hui, MD, PhD; D. Zheng, MD, Hypertension Division, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital; and the National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.
authors.forename: Deyu
authors.initials: D
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003131:Combined Modality Therapy; D015897:Comorbidity; D004244:Dizziness / Q000453:epidemiology*; D005260:Female; D005334:Fever / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013625:Takayasu Arteritis / Q000175:diagnosis* / Q000453:epidemiology* / Q000401:mortality; D016896:Treatment Outcome; D055815:Young Adult
keywords: ANGIOGRAPHY; CORONARY ARTERY; PULMONARY ARTERY; RENAL ARTERY; TAKAYASU ARTERITIS