title: Gastrointestinal bleed induced by a fixed dose combination of rabeprazole and diclofenac sodium.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are known to cause gastrointestinal (GI) bleed. Co-administration of proton pump inhibitors (PPIs) has been widely suggested as one of the strategies to prevent these GI complications among NSAIDs users. Herein, we present a case of severe GI bleeding in a patient taking fixed dose combination (FDC) of rabeprazole (20 mg) and diclofenac sodium (100 SR).
authors.affiliation: Postgraduate Departments of Pharmacology and Therapeutic, Government Medical College, Jammu and Kashmir, India.
authors.forename: Vishal R
authors.initials: VR
authors.lastname: Tandon
authors.affiliation: Medicine (Gastroenterology), Government Medical College, Jammu and Kashmir, India.
authors.forename: Vijant
authors.initials: V
authors.lastname: Chandail
authors.affiliation: Postgraduate Departments of Pharmacology and Therapeutic, Government Medical College, Jammu and Kashmir, India.
authors.forename: Vijay
authors.initials: V
authors.lastname: Khajuria
authors.affiliation: Postgraduate Departments of Pharmacology and Therapeutic, Government Medical College, Jammu and Kashmir, India.
authors.forename: Zahid
authors.initials: Z
authors.lastname: Gillani
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D064750:Rabeprazole / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D054328:Proton Pump Inhibitors; D004008:Diclofenac; D064750:Rabeprazole
keywords: Diclofenac sodium; fixed dose combination; non-steroidal anti-inflammatory drugs; rabeprazole