title: Examination of clinical efficacy of keishibukuryogan on non-specific complaints associated with varicose veins of the lower extremity.
abstract: The subjective symptoms of varicose veins of the lower extremity often include malaise, numbness, coldness, pain, and pruritus of the lower extremity, and relieving these complaints is important in managing the quality of life of patients. We have examined the clinical efficacy of keishibukuryogan, a Kampo prescription for improving oketsu (impaired microcirculation, congestion), on non-specific complaints associated with varicose veins of the lower extremity. Keishibukuryogan was administered to 30 patients with non-specific complaints associated with varicose veins of the lower extremity for 12 weeks, resulting in improvements in the scores of subjective symptoms, severity of varicose veins, and oketsu as well as an increase in skin perfusion pressure. And especially the effect was remarkable in female. In addition, oketsu was shown to be involved in the subjective symptoms associated with varicose veins of the lower extremity, demonstrating efficacy of keishibukuryogan. No adverse drug reaction or abnormal laboratory result was observed in patients receiving keishibukuryogan, and the rate of general improvement and usefulness was 73.3%. It was suggested that keishibukuryogan was useful to improve the symptoms of patients with non-specific complaints associated with varicose veins of the lower extremity especially in female patients. (English translation of Jpn J Phlebol 2013; 24: 303-310).
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hayashi
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Shibutani
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Hirotoki
authors.initials: H
authors.lastname: Okubo
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Shimogawara
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ichinose
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Kouki
authors.initials: K
authors.lastname: Mihara
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Egawa
authors.affiliation: Department of Surgery (Vascular Surgery), Saiseikai Yokohamashi Tobu Hospital, Yokohama, Kanagawa, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagashima
authors.affiliation: Department of Surgery, Keio University, Tokyo, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Obara
authors.affiliation: Department of Surgery, Keio University, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
keywords: Kampo prescription; keishibukuryogan; non-specific complaints; oketsu; varicose veins of the lower extremity