title: Translational studies of A20 in atherosclerosis and cardiovascular disease.
abstract: Cardiovascular disease (CVD) is the biggest killer in the Western World despite significant advances in understanding its molecular underpinnings. Chronic inflammation, the classical hallmark of atherogenesis is thought to play a key pathogenic role in the development of atherosclerotic lesions from initiation of fatty streaks to plaque rupture. Over-representation of mostly pro-inflammatory nuclear factor kappa B (NF-kappaB) target genes within atherosclerotic lesions has led to the common-held belief that excessive NF-kappaB activity promotes and aggravates atherogenesis. However, mouse models lacking various proteins involved in NF-kappaB signaling have often resulted in conflicting findings, fueling additional investigations to uncover the molecular involvement of NF-kappaB and its target genes in atherogenesis. In this chapter we will review the role of the NF-kappaB-regulated, yet potent NF-kappaB inhibitory and anti-inflammatory gene A20/TNFAIP3 in atherogenesis, and highlight the potential use of its atheroprotective properties for the prevention and treatment of cardiovascular diseases.
authors.forename: Fiona C
authors.initials: FC
authors.lastname: McGillicuddy
authors.forename: Herwig P
authors.initials: HP
authors.lastname: Moll
authors.forename: Samira
authors.initials: S
authors.lastname: Farouk
authors.forename: Scott M
authors.initials: SM
authors.lastname: Damrauer
authors.forename: Christiane
authors.initials: C
authors.lastname: Ferran
authors.forename: Muredach P
authors.initials: MP
authors.lastname: Reilly
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D019610:Cytoprotection; D004268:DNA-Binding Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008297:Male; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D016328:NF-kappa B / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology*; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; D009687:Nuclear Proteins; D014409:Tumor Necrosis Factor-alpha; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3