title: Mitochondria-targeting phosphorescent iridium(III) complexes for living cell imaging.
abstract: Two phosphorescent iridium(III) complexes conjugated to a lipophilic triphenylphosphonium cation moiety, IrMitoOlivine and IrMitoNIR, were synthesized. The complexes show high mitochondria-specificity and relatively lower cytotoxicity. Time-lapse confocal imaging indicates that both complexes exhibit an excellent anti-photobleaching capability under continuous laser irradiation.
authors.affiliation: Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu 215123, P. R. China. mzhou2007@sinano.ac.cn.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Cao
authors.forename: Hao
authors.initials: H
authors.lastname: Fei
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
mesh_terms: D020003:1-Octanol / Q000737:chemistry; D001692:Biological Transport; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007495:Iridium / Q000737:chemistry / Q000494:pharmacology*; D049408:Luminescent Agents / Q000737:chemistry / Q000494:pharmacology*; D018613:Microscopy, Confocal; D008928:Mitochondria / Q000378:metabolism*; D012965:Sodium Chloride / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D049408:Luminescent Agents; D007495:Iridium; D012965:Sodium Chloride; D020003:1-Octanol