title: Papillary thyroid cancer, macrofollicular variant: the follow-up and analysis of prognosis of 5 patients.
abstract: Objective. The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant. Methods. The demographic data, radiological and pathological data, and prognostic data of 5 patients who underwent surgery for thyroid cancer and were diagnosed with papillary cancer macrofollicular variant pathologically were retrospectively analyzed. Results. The mean age of patients whose mean follow-up period was determined as 7.2 years was 41, and the male/female ratio was 4/1. All patients underwent total thyroidectomy. The pathology report of 2 patients (40%) revealed macrofollicular variant of papillary microcancer, and 3 patients papillary cancer macrofollicular variant. Central dissection was performed in one patient (20%) due to macroscopic pathologic lymph node and 4 metastatic lymph nodes were reported. Also, locoregional recurrence was present in 3 out of 5 patients (60%). Conclusions. Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required.
authors.affiliation: Division of Endocrine Surgery, Department of General Surgery, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Varlık
authors.initials: V
authors.lastname: Erol
authors.affiliation: Division of Endocrine Surgery, Department of General Surgery, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Ozer
authors.initials: O
authors.lastname: Makay
authors.affiliation: Department of Pathology, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Ertan
authors.affiliation: Division of Endocrine Surgery, Department of General Surgery, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Içöz
authors.affiliation: Division of Endocrine Surgery, Department of General Surgery, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Mahir
authors.initials: M
authors.lastname: Akyıldız
authors.affiliation: Division of Endocrine Surgery, Department of General Surgery, School of Medicine, Ege University, Bornova, 35100 Izmir, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Yılmaz