title: Copper-catalyzed arylation of nitrogen heterocycles from anilines under ligand-free conditions.
abstract: The arylation of pyrazole and derivatives can be achieved by coupling arenediazonium species (formed in situ from anilines) by using a catalytic system that employs low-toxicity and inexpensive copper metal under very mild and ligand-free conditions (T=20 °C). From other nitrogen heterocycles, the presence of an additive (NBu4 I) significantly improves the efficiency of the catalytic system. These results represent the first examples of CN bond formation from arenediazonium species.
authors.affiliation: Institut Charles Gerhardt Montpellier, ENSCM, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex 5 (France), Fax: (+33) 467144319.
authors.forename: Dounia
authors.initials: D
authors.lastname: Toummini
authors.forename: Anis
authors.initials: A
authors.lastname: Tlili
authors.forename: Julien
authors.initials: J
authors.lastname: Bergès
authors.forename: Fouad
authors.initials: F
authors.lastname: Ouazzani
authors.forename: Marc
authors.initials: M
authors.lastname: Taillefer
keywords: anilines; arylation; catalysis; copper; nitrogen heterocycles