title: Significance of osteogenic surface coatings on implants to enhance osseointegration under osteoporotic-like conditions.
abstract: OBJECTIVE
  The aim was to assess the significance of osteogenic surface coatings on implants to enhance osseointegration under osteoporotic-like (OP-like) conditions.
  
  
  METHODS
  To address the focused question "Do osteogenic surface coatings on implants enhance osseointegration under OP-like conditions?" PubMed/MEDLINE and Google-Scholar databases were searched from 1995 up to and including February 2014 using various keywords. Unpublished data, letters to the editor, review articles, and articles published in languages other than English were excluded.
  
  
  RESULTS
  Of the 28 studies identified, 11 experimental studies were included. These studies were performed on bilaterally ovariectomized animals. In all studies, implant surface roughness was increased by various osteogenetic surface coatings including alumina, hydroxyapatite, calcium phosphate, and zoledronic acid. Nine studies reported that compared with non-coated surfaces, osteogenic coatings on implant surfaces increases bone volume and bone-to-implant contact (BIC) under OP-like conditions. In 2 studies, there was no difference in BIC around hydroxyapatite-coated implants placed in animals with and without OP-like conditions.
  
  
  CONCLUSIONS
  Osteogenic coatings on implant surfaces enhanced osseointegration in animals with OP-like conditions. However, additional clinical studies are warranted to assess the role of osteogenic coatings in increasing osseointegration in patients with osteoporosis.
authors.affiliation: *Assistant Professor, Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration, 3D Imaging and Biomechanical Laboratory, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. †Assistant Professor, Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. ‡Assistant Professor, Department of Dental Biomaterials, College of Dentistry, Taibah University, Madinah, Saudi Arabia. §Professor, Division of Periodontology, College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
authors.forename: Fawad
authors.initials: F
authors.lastname: Javed
authors.forename: Fahim
authors.initials: F
authors.lastname: Vohra
authors.forename: Sohail
authors.initials: S
authors.lastname: Zafar
authors.forename: Khalid
authors.initials: K
authors.lastname: Almas
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D004164:Diphosphonates / Q000494:pharmacology; D005260:Female; D016348:Osseointegration / Q000187:drug effects*; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy; D013499:Surface Properties
chemical_list: D050071:Bone Density Conservation Agents; D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D004164:Diphosphonates