title: Cycloadditions of cyclohexynes and cyclopentyne.
abstract: We report the strategic use of cyclohexyne and the more elusive intermediate, cyclopentyne, as a tool for the synthesis of new heterocyclic compounds. Experimental and computational studies of a 3-substituted cyclohexyne are also described. The observed regioselectivities are explained by the distortion/interaction model.
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Los Angeles, California 90095, United States.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Medina
authors.forename: Travis C
authors.initials: TC
authors.lastname: McMahon
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Jiménez-Osés
authors.forename: K N
authors.initials: KN
authors.lastname: Houk
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D061565:Cycloaddition Reaction; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D000480:Alkynes; D003517:Cyclopentanes