title: Reversion-Inducing-Cysteine-Rich Protein With Kazal Motifs (RECK) Gene Single Nucleotide Polymorphism With Hepatocellular Carcinoma: A Case-Control Study.
abstract: BACKGROUND
  The reversion-inducing-cysteine-rich protein with kazal motifs (RECK) gene is a transformation suppressor gene that can negatively regulate matrix metalloproteinases (MMPs) and inhibit tumor invasion, angiogenesis, and metastasis. So, the aim of this study was to analyze the effect of RECK gene rs 11788747 single nucleotide polymorphism (SNP) on hepatocellular carcinoma (HCC) susceptibility and its relation to various clinical and laboratory data of the patients.
  
  
  METHODS
  This is a case-control study including 200 HCC patients and 200 healthy controls. RECK rs 11788747 genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  RECK rs 11788747 A/G and G/G genotypes frequencies were significantly higher in HCC patients compared to the healthy controls. The HCC patients possessing at least one polymorphic G allele were significantly at a higher risk of developing lymph nodes involvement and distant metastasis.
  
  
  CONCLUSIONS
  This study revealed the role of RECK rs 11788747 SNP in HCC in Egyptian patients, which consequently might be used as a prognostic tool and could be added to its therapeutic strategies.
authors.affiliation: Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Dina M Rasheed
authors.initials: DM
authors.lastname: Bahgat
authors.affiliation: Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Rasha Mohamad Hosny
authors.initials: RM
authors.lastname: Shahin
authors.affiliation: Department of Clinical Pathology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Nada Nasr
authors.initials: NN
authors.lastname: Makar
authors.affiliation: Department of Tropical Medicine and Hepatology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Ashraf Omar Abdel
authors.initials: AO
authors.lastname: Aziz
authors.affiliation: Department of Endemic Medicine, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
authors.forename: Shereen Shoukry
authors.initials: SS
authors.lastname: Hunter
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D058851:GPI-Linked Proteins; C115460:RECK protein, human
keywords: Egypt; HCC; RECK; rs 11788747