title: Sensory contribution to vocal emotion deficit in Parkinson's disease after subthalamic stimulation.
abstract: Subthalamic nucleus (STN) deep brain stimulation in Parkinson's disease induces modifications in the recognition of emotion from voices (or emotional prosody). Nevertheless, the underlying mechanisms are still only poorly understood, and the role of acoustic features in these deficits has yet to be elucidated. Our aim was to identify the influence of acoustic features on changes in emotional prosody recognition following STN stimulation in Parkinson's disease. To this end, we analysed the performances of patients on vocal emotion recognition in pre-versus post-operative groups, as well as of matched controls, entering the acoustic features of the stimuli into our statistical models. Analyses revealed that the post-operative biased ratings on the Fear scale when patients listened to happy stimuli were correlated with loudness, while the biased ratings on the Sadness scale when they listened to happiness were correlated with fundamental frequency (F0). Furthermore, disturbed ratings on the Happiness scale when the post-operative patients listened to sadness were found to be correlated with F0. These results suggest that inadequate use of acoustic features following subthalamic stimulation has a significant impact on emotional prosody recognition in patients with Parkinson's disease, affecting the extraction and integration of acoustic cues during emotion perception.
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology and Swiss Centre for Affective Sciences, University of Geneva, Switzerland. Electronic address: julie.peron@unige.ch.
authors.forename: Julie
authors.initials: J
authors.lastname: Péron
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology and Swiss Centre for Affective Sciences, University of Geneva, Switzerland.
authors.forename: Sezen
authors.initials: S
authors.lastname: Cekic
authors.affiliation: MediCIS, INSERM, Faculty of Medicine, University of Rennes I, France; Neurosurgery Department, Rennes University Hospital, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Haegelen
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France; Physiology Department, Rennes University Hospital, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Sauleau
authors.affiliation: Department of Speech Language Pathology, Seton Hall University, South Orange, NJ, USA.
authors.forename: Sona
authors.initials: S
authors.lastname: Patel
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France; Adult Psychiatry Department, Guillaume Régnier Hospital, Rennes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Drapier
authors.affiliation: 'Behavior and Basal Ganglia' Research Unit, University of Rennes 1, Rennes University Hospital, France; Neurology Department, Rennes University Hospital, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Vérin
authors.affiliation: 'Neuroscience of Emotion and Affective Dynamics' Laboratory, Department of Psychology and Swiss Centre for Affective Sciences, University of Geneva, Switzerland.
authors.forename: Didier
authors.initials: D
authors.lastname: Grandjean
mesh_terms: D000368:Aged; D046690:Deep Brain Stimulation; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D021641:Recognition, Psychology / Q000502:physiology*; D013060:Speech; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D014831:Voice
keywords: Basal ganglia; Deep brain stimulation; Emotional prosody; Parkinson's disease; Subthalamic nucleus