title: Possible mechanism for down-regulation of autoantibody production by auto-anti-idiotype.
abstract: Once it is recognized that antigen and anti-idiotype antibody can both react with idiotype-bearing cells, it becomes apparent that there are certain similarities and differences in the consequences of these interactions. It is therfoore interesting to consider why anti-idiotype antibody might differ from antigen in its effect on cells. Here the authors suggest a possible mechanism for down-regulation of auto-antibody production by auto-anti-idiotype.
authors.affiliation: Department of Pathology, New York University Medical School, New York, NY 10016, USA; Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Thorbecke
authors.affiliation: Department of Pathology, New York University Medical School, New York, NY 10016, USA; Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Bhogal
authors.affiliation: Department of Pathology, New York University Medical School, New York, NY 10016, USA; Division of Allergy and Immunology, Department of Medicine, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Siskind