title: Mechanism of the Neurospora circadian clock, a FREQUENCY-centric view.
abstract: Circadian clocks are self-sustaining timekeepers found in almost all organisms on earth. The filamentous fungus Neurospora crassa is a preeminent model for eukaryotic circadian clocks. Investigations of the Neurospora circadian clock system have led to elucidation of circadian clock regulatory mechanisms that are common to all eukaryotes. In this work, we will focus on the Neurospora circadian oscillator mechanism with an emphasis on the regulation of the core clock component FREQUENCY.
authors.affiliation: Department of Physiology, University of Texas Southwestern Medical Center , 5323 Harry Hines Boulevard, Dallas, Texas 75390-9040, United States.
authors.forename: Joonseok
authors.initials: J
authors.lastname: Cha
authors.forename: Mian
authors.initials: M
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D057906:Circadian Clocks; D025461:Feedback, Physiological; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D009492:Neurospora crassa / Q000235:genetics* / Q000502:physiology
chemical_list: C087405:FRQ protein, Neurospora crassa; D005656:Fungal Proteins