title: Does T-cell restriction to Ia limit the need for self-tolerance?
abstract: Why did two classes ofMHC molecule evolve as restricting elements in T-cell function? Here Carol Cowing discusses the hypothesis that incomplete self-tolerance may explain the necessity for class II MHC restriction.
authors.affiliation: Division of Research Immunology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
authors.forename: C
authors.initials: C
authors.lastname: Cowing