title: A novel oxybis cresol verticilatin with highly varying degrees of biological activities from the insect pathogenic fungus Paecilomyces verticillatus.
abstract: A novel oxybis cresol compound named verticilatin (1), together with two known compounds, 5-methylresorcinol (2) and 2,4-dihydroxy-3,6-dimethylbenzaldehyde (3), was isolated from cultures of the insect pathogenic fungi Paecilomyces verticillatus. The structures of compounds were determined by extensive spectroscopic analysis of HR-ESI-MS and 1D and 2D NMR including HSQC, HMBC, COSY, and ROESY. Fortunately, compound 1 exhibited significant inhibitory activities against CDC25B, cathepsin B, MEG2, and SHP2 enzyme, with IC50 values of 11.5, 3.5, 7.8, and 15 μg/ml, respectively.
authors.affiliation: a Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education , College of Life Science, Hebei University , Baoding 071002 , China.
authors.forename: Pei-Yao
authors.initials: PY
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Chun-Gui
authors.initials: CG
authors.lastname: Yang
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Zheng
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lu
authors.forename: Bao-Zhong
authors.initials: BZ
authors.lastname: Shi
mesh_terms: D000818:Animals; D001547:Benzaldehydes; D002401:Cathepsin B / Q000378:metabolism; D003408:Cresols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007313:Insecta / Q000382:microbiology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010143:Paecilomyces / Q000737:chemistry*; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: C534908:2,4-dihydroxy-3,6-dimethylbenzaldehyde; D001547:Benzaldehydes; D003408:Cresols; C000595813:verticilatin; D017027:Protein Tyrosine Phosphatases; D002401:Cathepsin B
keywords: Paecilomyces verticillatus; biological activity; insect pathogenic fungi; verticilatin