title: Amplitude-integrated electroencephalographic activity and middle cerebral artery Doppler flow measurements in preterm small for gestational age infants.
abstract: Amplitude-integrated encephalography (EEG) is frequently used in neonatal intensive care units to monitor brain functions. Its bedside application and easy interpretation are the most important features. Brain development of small for gestational age infants can be affected by intrauterine chronic hypoxia. The current study aimed to evaluate cerebral functions of small for gestational age infants by means of amplitude-integrated EEG. Thirty- to 34-week-old 22 small for gestational age and 27 appropriate for gestational age preterm infants were included in the study. The mode of delivery, gender, birth weight, and Apgar scores of the patients were recorded. Following middle cerebral artery mean velocity measurement with cranial Doppler at the 24th hour of birth, an amplitude-integrated EEG recording was performed on all infants, for a period of 4 to 24 hours. Small for gestational age infants had significantly higher middle cerebral artery mean velocity than appropriate for gestational age infants (21.09 ± 4.25 vs 17.8 ± 4.07; P = .029). The amplitude-integrated EEG recordings showed lower "lower border of quiet sleep" and total Burdjalov score in small for gestational age infants when compared with appropriate for gestational age infants (2.5 [1-3.25] µV vs 3 [2.75-4] µV; P = .04, 8 [6-10], 9 [9-11]; P = .04, respectively). Increased middle cerebral artery blood flow observed in small for gestational age infants might be a marker of chronic intrauterine hypoxia to which these infants were exposed. These infants demonstrated a more immature pattern of amplitude-integrated EEG.
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey dr._leyla@hotmail.com.
authors.forename: Leyla Daban
authors.initials: LD
authors.lastname: Kolsuz
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Sevilay
authors.initials: S
authors.lastname: Topcuoglu
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Gursoy
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: Güner
authors.initials: G
authors.lastname: Karatekin
authors.affiliation: Zeynep Kamil Maternity and Children's Training and Research Hospital, Istanbul, Turkey.
authors.forename: H Fahri
authors.initials: HF
authors.lastname: Ovali
mesh_terms: D001034:Apgar Score; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D008297:Male; D020768:Middle Cerebral Artery / Q000502:physiology*; D011446:Prospective Studies; D018608:Ultrasonography, Doppler
keywords: amplitude-integrated EEG; middle cerebral artery blood flow; prematurity; small for gestational age infant