title: Auditory neuroplasticity, hearing loss and cochlear implants.
abstract: Data from our laboratory show that the auditory brain is highly malleable by experience. We establish a base of knowledge that describes the normal structure and workings at the initial stages of the central auditory system. This research is expanded to include the associated pathology in the auditory brain stem created by hearing loss. Utilizing the congenitally deaf white cat, we demonstrate the way that cells, synapses, and circuits are pathologically affected by sound deprivation. We further show that the restoration of auditory nerve activity via electrical stimulation through cochlear implants serves to correct key features of brain pathology caused by hearing loss. The data suggest that rigorous training with cochlear implants and/or hearing aids offers the promise of heretofore unattained benefits.
authors.affiliation: Hearing Research, Garvan Institute, Darlinghurst, NSW, Australia, david.ryugo@gmail.com.
authors.forename: David
authors.initials: D
authors.lastname: Ryugo
mesh_terms: D000818:Animals; D002415:Cats; D003051:Cochlea / Q000473:pathology*; D003054:Cochlear Implants / Q000706:statistics & numerical data*; D034381:Hearing Loss / Q000209:etiology / Q000628:therapy*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*