title: Fluid therapy in critical illness.
abstract: Major surgery and critical illnesses such as sepsis and trauma all disturb normal physiological fluid handling. Intravenous fluid therapy for resuscitation and fluid maintenance is a central part of medical care during these conditions, yet the evidence base supporting practice in this area lacks answers to a number of important questions. Recent research developments include a refinement of our knowledge of the endothelial barrier structure and function and a focus on the potential harm that may be associated with intravenous fluid therapy. Here, we briefly describe the contemporary view of fluid physiology and how this may be disrupted by pathological processes. The important themes in critical illness fluid research are discussed, with a particular focus on two emerging ideas: firstly, that individualising fluid treatment to the patient, their underlying disease state and the phase of that illness may be key to improving clinical outcomes using fluid interventions and, secondly, that fluids should be considered to be drugs, with specific indications and contraindications, dose ranges and potential toxicities.
authors.affiliation: Department of Anaesthesia, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, Tremona Road, Southampton SO16 6YD, UK ; NIHR Southampton Respiratory Biomedical Research Unit, Southampton, UK.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Edwards
authors.affiliation: Department of Anaesthesia and Critical Care, University College London Hospitals, London, UK ; University College London, London, UK ; UCLH/UCL NIHR Comprehensive Biomedical Research Centre, London, UK.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Mythen
keywords: Critical illness; Glycocalyx; Goal-directed therapy; Intravenous fluid; Surgery