title: Technology-based assessment in patients with disorders of consciousness.
abstract: BACKGROUND
  A number of studies highlight the difficulty in forming a diagnosis for patients with disorders of consciousness when this is established merely on behavioral assessments.
  
  
  BACKGROUND
  Positron emission tomography (PET), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), and electroencephalography combined with transcranial magnetic stimulation (TMS-EEG) techniques are promoting the clinical characterization of this challenging population. With such technology-based "objective" tools, patients are also differentially able to follow simple commands and in some cases even communicate through modified brain activity. Consequently, the vegetative state and minimally conscious state have been revised and new nosologies have been proposed, namely the unresponsive wakefulness syndrome, the minimally conscious state plus and minus, and the functional locked-in syndrome.
  
  
  OBJECTIVE
  To our mind, an integration of different technical modalities is important to gain a holistic vision of the underlying pathophysiology of disorders of consciousness in general and to promote single-patient medical management in particular.
authors.affiliation: Istituto Neurologico Nazionale C. Mondino, Neuroradiologia, Pavia, Italy.
authors.forename: Carol
authors.initials: C
authors.lastname: Di Perri
authors.forename: Lizette
authors.initials: L
authors.lastname: Heine
authors.forename: Enrico
authors.initials: E
authors.lastname: Amico
authors.forename: Andrea
authors.initials: A
authors.lastname: Soddu
authors.forename: Steven
authors.initials: S
authors.lastname: Laureys
authors.forename: Athena
authors.initials: A
authors.lastname: Demertzi
mesh_terms: D003244:Consciousness Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D059906:Neuroimaging; D049268:Positron-Emission Tomography