title: TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.
abstract: Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an independent predictor for 5-year overall survival rate (HR, 1.832; 95% CI, 1.237-4.146 [P = 0.041]). In conclusion, TRPM7 promotes the metastasis of NPC and may serve as a prognostic marker in NPC patients.
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China. Electronic address: wbwb1620@163.com.
authors.forename: Jian-Peng
authors.initials: JP
authors.lastname: Chen
authors.affiliation: Department of Oncology, General Hospital, Jinan Command of the People's Liberation Army, Jinan, 250031, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Center for Disease Control, Jinan Command of the People's Liberation Army, Jinan, 250014, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luan
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Cai-Xia
authors.initials: CX
authors.lastname: Wang
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Wen-Huan
authors.initials: WH
authors.lastname: Li
authors.affiliation: Department of Oncology, the 148th Hospital, Jinan Command of the People's Liberation Army, Zibo, 255300, China.
authors.forename: Jin-Biao
authors.initials: JB
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Sha
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Shen
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Yan-Gang
authors.initials: YG
authors.lastname: Cui
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Rheumatology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Provincial Hospital affiliated to Shandong University, Jinan, 250021, China.
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Wang
mesh_terms: D015153:Blotting, Western; D002277:Carcinoma; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism / Q000556:secondary*; D009305:Nasopharynx / Q000378:metabolism* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases; D012333:RNA, Messenger / Q000235:genetics; D034741:RNA, Small Interfering / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D050053:TRPM Cation Channels / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D034741:RNA, Small Interfering; D050053:TRPM Cation Channels; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human
keywords: Metastasis; Migration; Nasopharyngeal carcinoma; Prognosis; TRPM7