title: Quantitative variation in la antigen expression plays a central role in immune regulation.
abstract: The analysis of la antigen function has focused primarily on allelic variants of Ia molecules. In this review Charles Janeway and his colleagues discuss evidence that quantitative rather than qualitative variation in Ia antigen expression had a major role in immunoregulation and immunologically mediated disease.
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Janeway
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: K
authors.initials: K
authors.lastname: Bottomly
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: J
authors.initials: J
authors.lastname: Babich
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: P
authors.initials: P
authors.lastname: Conrad
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: S
authors.initials: S
authors.lastname: Conzen
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: B
authors.initials: B
authors.lastname: Jones
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: J
authors.initials: J
authors.lastname: Kaye
authors.affiliation: Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: M
authors.initials: M
authors.lastname: Katz
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: L
authors.initials: L
authors.lastname: McVay
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Murphy
authors.affiliation: Department of Pathology, Division of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: J
authors.initials: J
authors.lastname: Tite