title: Investigation of magnetically controlled water intake behavior of Iron Oxide Impregnated Superparamagnetic Casein Nanoparticles (IOICNPs).
abstract: Iron oxide impregnated casein nanoparticles (IOICNPs) were prepared by in-situ precipitation of iron oxide within the casein matrix. The resulting iron oxide impregnated casein nanoparticles (IOICNPs) were characterized by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared (FTIR), Vibrating sample magnetometer (VSM) and Raman spectroscopy. The FTIR analysis confirmed the impregnation of iron oxide into the casein matrix whereas XPS analysis indicated for complete oxidation of iron (II) to iron(III) as evident from the presence of the observed representative peaks of iron oxide. The nanoparticles were allowed to swell in phosphate buffer saline (PBS) and the influence of factors such as chemical composition of nanoparticles, pH and temperature of the swelling bath, and applied magnetic field was investigated on the water intake capacity of the nanoparticles. The prepared nanoparticles showed potential to function as a nanocarrier for possible applications in magnetically targeted delivery of anticancer drugs.
authors.affiliation: BMRL, Department of Chemistry, Government Model Science College, Jabalpur, India. singhanamika16488@gmail.com.
authors.forename: Anamika
authors.initials: A
authors.lastname: Singh
authors.affiliation: BMRL, Department of Chemistry, Government Model Science College, Jabalpur, India. jayabajpailab@yahoo.com.
authors.forename: Jaya
authors.initials: J
authors.lastname: Bajpai
authors.affiliation: BMRL, Department of Chemistry, Government Model Science College, Jabalpur, India. akbmrl@yahoo.co.in.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Bajpai
mesh_terms: D000818:Animals; D002364:Caseins / Q000737:chemistry*; D002478:Cells, Cultured; D005290:Ferric Compounds / Q000737:chemistry*; D005347:Fibroblasts / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D056951:Photoelectron Spectroscopy; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman; D014867:Water / Q000737:chemistry
chemical_list: D002364:Caseins; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D014867:Water; C000499:ferric oxide