title: [Hyperechogenic fetal bowel: Which fetal and neonatal outcome? A French study of 149 cases].
abstract: OBJECTIVE
  In case of hyperechogenic fetal bowel (HFB), invasive procedures such as amniocentesis are often proposed to detect an underlying cause. Our goal is to study etiologies and prognosis of HFB according to antenatal sonographic findings in order to evaluate the relevance of antenatal assessment.
  
  
  METHODS
  It is a retrospective monocentric study lead from 2008 to 2012, including all patients with a suspicion of HFB on routine sonography. We analysed the antenatal and neonatal results, distinguishing four situations: isolated HFB, HFB+other digestive anomalies, HFB+vascular pathology, HFB+other associated anomalies.
  
  
  RESULTS
  For 149 patients, HBF was confirmed. Sixty-nine were isolated HFB, 24 associated with other digestive anomalies, 16 with vascular pathology and 40 with other anomalies. Pregnancy outcomes were different with 92.8, 41.7, 0 and 45.0% of healthy newborns. In the case of isolated HBF, we noted 2.9% cystic fibrosis and 2.9% congenital infection.
  
  
  CONCLUSIONS
  Isolated HBF seems to have a better prognosis than associated forms. However, prenatal investigations to eliminate cystic fibrosis or congenital infection should be offered and may be initially non-invasive, if a larger series confirmed the absence of dyschromosomy in this population.
authors.affiliation: Pôle femme mère nouveau-né, clinique d'obstétrique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France. Electronic address: geraldine.bleu@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Bleu
authors.affiliation: Pôle femme mère nouveau-né, clinique d'obstétrique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Coulon
authors.affiliation: Pôle femme mère nouveau-né, clinique d'obstétrique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.affiliation: Pôle femme mère nouveau-né, clinique d'obstétrique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Bourgeot
authors.affiliation: Clinique de chirurgie pédiatrique, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille, France.
authors.forename: R
authors.initials: R
authors.lastname: Sfeir
authors.affiliation: Service de génétique clinique, hôpital Jeanne-de-Flandre, CHRU de Lille, 59037 Lille, France.
authors.forename: O
authors.initials: O
authors.lastname: Boute
authors.affiliation: Pôle femme mère nouveau-né, clinique d'obstétrique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinée, 59037 Lille cedex, France; Faculté de médecine, université Lille Nord-de-France, 59045 Lille cedex, France.
authors.forename: V
authors.initials: V
authors.lastname: Houfflin-Debarge
mesh_terms: D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology*; D058535:Echogenic Bowel / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology*; D005602:France; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D016216:Ultrasonography, Prenatal
keywords: Antenatal diagnosis; Cystic fibrosis; Diagnostic anténatal; Dyschromosomie; Dyschromosomy; Hyperechogenic fetal bowel; Hyperéchogénicité intestinale; Mucoviscidose