title: Effects of low concentrations of benzene exposure on levels of platelet-associated antibodies and platelet parameters.
abstract: OBJECTIVE
  To evaluate the impact of exposure to low concentrations of benzene on the platelet-associated antibodies and platelet parameters.
  
  
  METHODS
  We carried out an analysis on 121 benzene-exposed workers and 110 healthy workers whose blood samples were collected and the levels of platelet-associated antibodies and platelet parameters were assessed. Benzene emissions were monitored over 5 years.
  
  
  RESULTS
  Large-platelet cell ratios (P-LCR), platelet distribution width (PDW), and mean platelet volume (MPV) were significantly higher in benzene-exposed participants than in control participants. In participants who smoke cigarettes or drank alcohol, P-LCR, PDW, and MPV were more significantly elevated in the benzene-exposed group than in nonsmokers and nondrinkers. Platelet-associated immunoglobulin (PAIg) levels in benzene-exposed participants were higher than those in the control group, and PAIgA and PAIgM levels correlated with cumulative benzene exposure.
  
  
  CONCLUSIONS
  Exposure to low concentrations of benzene can induce changes in PAIg levels and platelet parameters.
authors.affiliation: From the Department of Occupational Disease (Dr Huang, Mr Wang, Ms Li, Ms Ma, and Dr Zhou), Department of Orthopaedics (Dr Zhao), and Central laboratory (Mr Zhang), Jinshan Hospital, Fudan University, Shanghai, China.
authors.forename: Jianshu
authors.initials: J
authors.lastname: Huang
authors.forename: Mingdong
authors.initials: M
authors.lastname: Zhao
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Xiuju
authors.initials: X
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuanling
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D016824:Antigens, Human Platelet / Q000097:blood*; D001554:Benzene / Q000633:toxicity*; D001792:Blood Platelets / Q000187:drug effects*; D002681:China; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D000906:Antibodies; D016824:Antigens, Human Platelet; D001554:Benzene