title: Lipid Lowering Effect of Punica granatum L. Peel in High Lipid Diet Fed Male Rats.
abstract: Many herbal medicines have been recommended for the treatment of dyslipidemia. The antilipidemic effect of hydroethanolic extract of pomegranate peel (Punica granatum L.) was investigated in high lipid diet fed male rats. Intraperitoneally administration of pomegranate peel extract (50, 100, 200, and 300 mg/kg body weight) for 23 days on the levels of serum cholesterol, triglycerides, LDL, HDL, alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in high lipid diet fed male rats was evaluated. Treatment of pomegranate extract decreased body weight in treated rats, significantly. Administration of the plant extract significantly decreased serum total cholesterol, triglycerides, LDL-C, alkaline phosphatise, AST, and ALT levels, whereas it increased serum HDL-C in high lipid diet fed rats in comparison to saline control group. Also, histopathological study showed that treatment of pomegranate peel extract attenuates liver damage in high lipid diet fed rats in comparison to saline group. It is concluded that the plant should be considered as an excellent candidate for future studies on dyslipidemia.
authors.affiliation: Department of Pathology, Rasoul Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Sadeghipour
authors.affiliation: Department of Biology, College of Biological Sciences, Varamin-Pishva Branch, Islamic Azad University, Varamin, Iran.
authors.forename: Maryam
authors.identifier: 0000-0002-6560-7845
authors.initials: M
authors.lastname: Eidi
authors.affiliation: Young Researchers and Elite Club, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ilchizadeh Kavgani
authors.affiliation: Young Researchers and Elite Club, Islamic Azad University, Varamin-Pishva Branch, Varamin, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Ghahramani
authors.affiliation: Young Researchers and Elite Club, Islamic Azad University, Tehran Medical Sciences Branch, Tehran, Iran.
authors.forename: Saleh
authors.initials: S
authors.lastname: Shahabzadeh
authors.affiliation: Department of Veterinary, College of Agriculture, Abhar Branch, Islamic Azad University, Abhar, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Anissian