title: Cystic fibrosis (cf) and ovarian reserve: A cross-sectional study examining serum anti-mullerian hormone (amh) in young women.
abstract: BACKGROUND
  Reduced female fertility in CF is believed to be due to thick cervical mucous, poor nutritional status, functional hypogonadotropic hypogonadism and possibly increased inflammation. Literature suggests that reduced ovarian reserve may also play a role.
  
  
  METHODS
  20 women with CF and 20 controls age 18-35 years were recruited. Serum anti-mullerian hormone (AMH), estradiol and follicle stimulating hormone (FSH) were assessed as well as antral follicle count (AFC) using transvaginal ultrasound.
  
  
  RESULTS
  Women with CF had significantly lower AMH levels than controls (17.8+/-4.7 vs. 33.2+/-21.0 pmol/L respectively; p=0.004). There were no differences in estradiol, FSH or AFC.
  
  
  CONCLUSIONS
  Women with CF have reduced ovarian reserve which may contribute to sub-fertility. CF care providers should consider referring women with CF to fertility specialists early to optimize chances of pregnancy.
authors.affiliation: Women's College Hospital, Department of Family and Community Medicine, 76 Grenville St, Toronto, Ontario M5S 1B1, Canada. Electronic address: carrie.schram@wchospital.ca.
authors.forename: C A
authors.initials: CA
authors.lastname: Schram
authors.affiliation: St. Michael's Hospital, Department of Respirology, Adult Cystic Fibrosis Clinic, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
authors.forename: A L
authors.initials: AL
authors.lastname: Stephenson
authors.affiliation: Hannam Fertility Centre, 160 Bloor St. E, Toronto, ON, M4W 1B9, Canada.
authors.forename: T G
authors.initials: TG
authors.lastname: Hannam
authors.affiliation: St. Michael's Hospital, Department of Respirology, Adult Cystic Fibrosis Clinic, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Tullis
mesh_terms: D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D019160:Endosonography; D005260:Female; D006801:Humans; D015994:Incidence; D009864:Ontario / Q000453:epidemiology; D065851:Ovarian Reserve / Q000502:physiology*; D011247:Pregnancy; D014621:Vagina; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone
keywords: Anti-mullerian hormone; Cystic fibrosis; Fertility; Pregnancy