title: Pyrone derivatives from the endophytic fungus Alternaria tenuissima SP-07 of Chinese herbal medicine Salvia przewalskii.
abstract: Three new pyrones, solanapyrones P-R (1-3), were afforded by the extracts of the endophytic fungus Alternaria tenuissima SP-07 isolated from the fresh root of Chinese herbal medicine Salvia przewalskii, along with the known solanapyrones (4-6) and benzopyrones (7-9). Solanapyrones P (1) and Q (2) possess an unprecedented nor-solanapyrone skeleton as natural products. Their structures were determined on the basis of NMR and HR-ESI-MS analysis. The plausible biosynthetic pathways to those unknown compounds were discussed. All the isolated compounds were evaluated for their antibacterial activities against six bacteria.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Xiao-Zheng
authors.initials: XZ
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Luo
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Zhai
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Institute of Biology, Gansu Academy of Sciences, Lanzhou 730000, PR China; State Key Laboratory of Grassland Agro-Ecosystems, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Cheng-Shan
authors.initials: CS
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China. Electronic address: wuqx@lzu.edu.cn.
authors.forename: Quan-Xiang
authors.initials: QX
authors.lastname: Wu
mesh_terms: D000528:Alternaria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018517:Plant Roots / Q000382:microbiology; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification; D027544:Salvia / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D011753:Pyrones
keywords: Alternaria tenuissima SP-07; Antibacterial activity; Endophytic fungus; Nor-solanapyrone