title: Mechanical nociception measurement in mice and rats with automated Von Frey equipment.
abstract: Von Frey hairs are important tools for the study of mechanisms of cutaneous stimulation-induced sensory input. Mechanical force is exerted via application of a particular hair to the cutaneous receptive field until buckling of the hair occurs. The most commonly used Von Frey filaments are productive in evaluating behavioral responses of neuropathic pain in preclinical and clinical research. To reduce the potential experimenter bias, automated instruments are being developed for behavioral assessment.
authors.affiliation: Pharmacy and Biotechnology Department - FaBiT, University of Bologna, Bologna, Italy, gabriele.campana@unibo.it.
authors.forename: Gabriele
authors.initials: G
authors.lastname: Campana
authors.forename: Roberto
authors.initials: R
authors.lastname: Rimondini
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000503:physiopathology*; D051379:Mice; D059225:Nociception / Q000187:drug effects*; D010147:Pain Measurement / Q000379:methods*; D017288:Pain Threshold; D010812:Physical Stimulation; D051381:Rats