title: Radiation oncology in vitro: trends to improve radiotherapy through molecular targets.
abstract: Much has been investigated to improve the beneficial effects of radiotherapy especially in that case where radioresistant behavior is observed. Beyond simple identification of resistant phenotype the discovery and development of specific molecular targets have demonstrated therapeutic potential in cancer treatment including radiotherapy. Alterations on transduction signaling pathway related with MAPK cascade are the main axis in cancer cellular proliferation even as cell migration and invasiveness in irradiated tumor cell lines; then, for that reason, more studies are in course focusing on, among others, DNA damage enhancement, apoptosis stimulation, and growth factors receptor blockages, showing promising in vitro results highlighting molecular targets associated with ionizing radiation as a new radiotherapy strategy to improve clinical outcome. In this review we discuss some of the main molecular targets related with tumor cell proliferation and migration as well as their potential contributions to radiation oncology improvements.
authors.affiliation: Research Institute of Internal and Preventive Medicine, FSBI, Boris Bogatkov Street 175/1, Novosibirsk 630089, Russia.
authors.forename: Natália
authors.initials: N
authors.lastname: Feofanova
authors.affiliation: School of Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena, 190 Santa Efigênia, 30130-100 Belo Horizonte, MG State, Brazil ; Alberto Cavalcanti Hospital, Minas Gerais State Hospital Foundation-FHEMIG, Rua Camilo de Brito, 636 Padre Eustáquio, 30730-540 Belo Horizonte, MG, Brazil.
authors.forename: Jony Marques
authors.initials: JM
authors.lastname: Geraldo
authors.affiliation: Department of Physics, Institute of Mathematical Sciences, Federal University of Minas Gerais, Avenida Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Lídia Maria
authors.initials: LM
authors.lastname: de Andrade
mesh_terms: D000818:Animals; D005544:Forecasting; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends*; D009363:Neoplasm Proteins / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D018787:Radiation Oncology / Q000639:trends*; D011878:Radiotherapy / Q000639:trends*
chemical_list: D009363:Neoplasm Proteins