title: Hepatitis e infection in a renal transplant recipient.
abstract: An asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. Liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. An extensive viral screen confirmed infection with Hepatitis E virus genotype 3 (HEV-3). There is increased awareness about locally acquired Hepatitis E virus (HEV) infection in the transplant population in the UK. The important implications of this infection are becoming more apparent as progression to liver cirrhosis can occur. However, the incidence, natural history, and treatment of HEV infection in the transplant population are not well established. This report illustrates a case of delayed spontaneous clearance of the HEV infection.
authors.affiliation: Department of Renal Medicine, Central Manchester NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
authors.forename: Diana
authors.identifier: 0000-0003-3265-6744
authors.initials: D
authors.lastname: Vassallo
authors.affiliation: Department of Clinical Virology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UK.
authors.forename: Mir Mubariz
authors.identifier: 0000-0002-6728-4090
authors.initials: MM
authors.lastname: Husain
authors.affiliation: Department of Hepatology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UK.
authors.forename: Shaun
authors.identifier: 0000-0002-2863-1459
authors.initials: S
authors.lastname: Greer
authors.affiliation: Department of Pathology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: McGrath
authors.affiliation: Blood Borne Virus Unit, MS-Colindale, Public Health England, London NW9 5EQ, UK.
authors.forename: Samreen
authors.identifier: 0000-0001-6658-3542
authors.initials: S
authors.lastname: Ijaz
authors.affiliation: Department of Renal Medicine, Central Manchester NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK.
authors.forename: Durga
authors.initials: D
authors.lastname: Kanigicherla