title: [Lack of association of COMT Val158Met polymorphism with attention and executive function in patients with schizophrenia].
abstract: OBJECTIVE
  To explore the association of a functional polymorphism Val158Met of COMT gene and attention and executive function in first-episode treatment-naive patients with schizophrenia and healthy controls.
  
  
  METHODS
  Trail making test (TMT) and clinical performances were evaluated in 103 first-episode treatment-naive patients with schizophrenia and 99 healthy controls. Polymorphism of COMT Val158Met was analyzed using polymerase chain reaction-restriction fragment length polymorphism method. A general linear model was used to investigate the effect of genotype subgroups on the attention and executive function.
  
  
  RESULTS
  There was a significant difference between control subjects and patients with schizophrenia on the TMT-A and B. However, no significant difference among Val/Val, Val/Met and Met/Met on the TMT-A and B in control subjects and patients with schizophrenia was detected.
  
  
  CONCLUSIONS
  The association among COMT Met variant and trail making testing (attention and executive function) has been replicated. However, no association of COMT Met variant with disruption of dopaminergic influence on neurocognitive function was detected. This may be due to the heterogeneity of population.
authors.affiliation: Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China xiangboyulan2012@gmail.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Yang
authors.forename: Linhui
authors.initials: L
authors.lastname: Liang
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Gu
authors.forename: Chaohua
authors.initials: C
authors.lastname: Huang
authors.forename: Mingli
authors.initials: M
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Ma
authors.forename: Yingcheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Liansheng
authors.initials: L
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Xiang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D001288:Attention / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D014145:Trail Making Test; D055815:Young Adult
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase