title: Cutaneous Alternaria infectoria infection diagnosed by molecular techniques in a renal transplant patient.
abstract: Organ transplant recipients under immunosuppressive therapy have a highly increased risk of opportunistic fungal infections. Cutaneous infection caused by Alternaria species are relatively rare in humans and most cases reported in the literature are in immunocompromised individuals. We report here on a 33-year old male renal transplant patient with diabetes mellitus who presented with cutaneous alternariosis caused by Alternaria infectoria, two years after the transplant. The diagnosis was performed by real-time polymerase chain reaction assay and histopathologic examination. The extension of the lesion under itraconazole treatment required treatment consisting of a combination of surgical excision and liposomal amphotericin B.
authors.forename: Duygu
authors.initials: D
authors.lastname: Daglar
authors.forename: Ayse
authors.initials: A
authors.lastname: Akman-Karakas
authors.forename: Betil
authors.initials: B
authors.lastname: Ozhak-Baysan
authors.forename: Filiz
authors.initials: F
authors.lastname: Gunseren
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Ciftcioglu
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Buitrago
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Rodriguez-Tudela
mesh_terms: D000328:Adult; D000528:Alternaria / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D060487:Alternariosis / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D001431:Bacteriological Techniques; D004271:DNA, Fungal / Q000302:isolation & purification*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D011237:Predictive Value of Tests; D060888:Real-Time Polymerase Chain Reaction; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004271:DNA, Fungal; D007166:Immunosuppressive Agents