title: Aquaporin-1 antibody in neuromyelitis optical patients.
abstract: METHODS
  To find out the prevalence of aquaporin-antibody (Aqp-Ab) and characterize Aqp-Ab associated clinical features in NMO, Aqp-1 and Aqp-4-Abs were examined using radioimmunoprecipitation and cell-based assays, respectively.
  
  
  RESULTS
  Aqp-4 and Aqp-1-Abs were detected in 20/30 and 8/30 NMO patients, respectively. One patient was Aqp-1-Ab single-positive, 13 patients were Aqp-4-Ab single-positive, 7 patients were Aqp-4/Aqp-1-Ab double-positive and 9 patients were seronegative. All double-positive patients had optic neuritis during the first attack. Only 2/29 MS patients and none of the control idiopathic intracranial hypertension patients were Aqp-1-Ab positive.
  
  
  CONCLUSIONS
  Aqp-1-Ab is usually detected in Aqp-4-Ab positive NMO patients and might be involved in optic neuritis pathogenesis.
authors.affiliation: Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: John
authors.initials: J
authors.lastname: Tzartos
authors.forename: Esme
authors.initials: E
authors.lastname: Ekizoğlu
authors.forename: Christos
authors.initials: C
authors.lastname: Stergiou
authors.forename: Paraskevi
authors.initials: P
authors.lastname: Zisimopoulou
authors.forename: Arzu
authors.initials: A
authors.lastname: Coban
authors.forename: Erkingül
authors.initials: E
authors.lastname: Shugaiv
authors.forename: Recai
authors.initials: R
authors.lastname: Türkoğlu
authors.forename: Murat
authors.initials: M
authors.lastname: Kürtüncü
authors.forename: Betül
authors.initials: B
authors.lastname: Baykan
authors.forename: Socrates
authors.initials: S
authors.lastname: Tzartos
mesh_terms: D000328:Adult; D051398:Aquaporin 1 / Q000276:immunology*; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D008297:Male; D009471:Neuromyelitis Optica / Q000097:blood*; D015531:Radioimmunoprecipitation Assay
chemical_list: C496020:AQP1 protein, human; C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D051398:Aquaporin 1