title: Change your TPLATE, change your fate: plant CME and beyond.
abstract: Clathrin-mediated endocytosis (CME) is the predominant and evolutionarily conserved pathway by which eukaryotes internalize cargoes (i.e., plasma membrane proteins, lipids, and extracellular material) that are engaged in a variety of processes. Initiation of CME relies on adaptor proteins, which precisely select the cargoes for internalization, recruit the clathrin cage, and start membrane curvature. The recently identified CME early adaptor complex, the TPLATE complex (TPC), is essential for CME in plants. Phylogenetic analyses suggest that the TPC evolved from an ancient protein complex involved in vesicle trafficking in early eukaryotes, which raises questions about CME evolution and adaptation within the eukaryotic Kingdoms. In this review, we focus on the early events of plant CME and explore evolutionary aspects related to CME in other eukaryotes.
authors.affiliation: Max-Planck-Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Max-Planck-Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany; ARC Centre of Excellence in Plant Cell Walls, School of Botany, University of Melbourne, Parkville 3010, VIC, Australia.
authors.forename: Staffan
authors.initials: S
authors.lastname: Persson
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Hirst
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
authors.forename: Margaret S
authors.initials: MS
authors.lastname: Robinson
authors.affiliation: Department of Plant Systems Biology, VIB, Technologiepark 927, B-9052 Gent, Belgium; Department of Plant Biotechnology and Bioinformatics, Gent University, B-9052 Gent, Belgium.
authors.forename: Daniel
authors.initials: D
authors.lastname: van Damme
authors.affiliation: Max-Planck-Institute for Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany. Electronic address: rodriguez@mpimp-golm.mpg.de.
authors.forename: Clara
authors.initials: C
authors.lastname: Sánchez-Rodríguez
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000235:genetics* / Q000378:metabolism; D005075:Biological Evolution; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis
chemical_list: D029681:Arabidopsis Proteins; D002966:Clathrin; C518499:TPLATE protein, Arabidopsis
keywords: AP-2 complex; TPLATE complex; clathrin-mediated endocytosis; eukaryote evolution; plant adaptor complexes