title: Pulmonary arterial hypertension associated with the use of interferon therapy for chronic hepatitis C infection complicated by extrinsic left main coronary artery compression.
abstract: Interferon-alpha treatment is a rare cause of pulmonary arterial hypertension (PAH). We report a case of a 43-year-old man treated for chronic hepatitis C infection complicated by decompensated right heart failure diagnosed with PAH and external coronary artery compression secondary to a dilated pulmonary trunk. The novel complication of extrinsic coronary artery compression should be considered in PAH patients presenting with chest pain or acute coronary syndrome. Establishing a diagnosis has clinical value as pulmonary vasodilator therapy may improve symptoms.
authors.affiliation: Department of Cardiology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: R D
authors.initials: RD
authors.lastname: Anderson
authors.forename: A
authors.initials: A
authors.lastname: Thompson
authors.forename: A T
authors.initials: AT
authors.lastname: Burns
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects; D002637:Chest Pain / Q000209:etiology / Q000503:physiopathology*; D023921:Coronary Stenosis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced*; D016898:Interferon-alpha / Q000009:adverse effects; D008297:Male; D010666:Phenylpropionates / Q000627:therapeutic use; D011651:Pulmonary Artery / Q000503:physiopathology*; D011724:Pyridazines / Q000627:therapeutic use; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D010666:Phenylpropionates; D011724:Pyridazines; D014665:Vasodilator Agents; C467894:ambrisentan
keywords: coronary artery compression; hepatitis c infection; interferon; pulmonary hypertension