title: [Pharmacological tolerance to medical therapy of organophosphate poisoning and ways of tolerance management].
abstract: Authors consider causes of low efficiency of antidote therapy and ways of pharmacological tolerance management during medical treatment of organophosphate poisoning. One of the promising ways is a preventive antidote on the base of enzyme agents and allosteric modulators of a cholinesterase activity. Authors showed a expediency of a study of new acetylcholinesterase reactivators, its compositions and ways of drug delivery. Authors specified ways of searching for anticonvulsants from classes of quick-closing benzodiatines and NMDA-antagonists. Authors defined ways of improvement of methods of special antidotes delivery with targeted transport system. Authors made an assumption about the necessity of symptomatic treatment.
authors.forename: M A
authors.initials: MA
authors.lastname: Iudin
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: S V
authors.initials: SV
authors.lastname: Chepur
authors.forename: A M
authors.initials: AM
authors.lastname: Sarana
authors.forename: V N
authors.initials: VN
authors.lastname: Tsygan
authors.forename: A G
authors.initials: AG
authors.lastname: Anokhin
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000927:Anticonvulsants / Q000627:therapeutic use*; D000931:Antidotes / Q000627:therapeutic use*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D016503:Drug Delivery Systems / Q000379:methods*; D004351:Drug Resistance / Q000187:drug effects*; D006801:Humans; D062025:Organophosphate Poisoning / Q000188:drug therapy* / Q000201:enzymology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists
chemical_list: D000927:Anticonvulsants; D000931:Antidotes; D002619:Chemical Warfare Agents; D016194:Receptors, N-Methyl-D-Aspartate; D000110:Acetylcholinesterase