title: Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein.
abstract: OBJECTIVE
  To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO2) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy.
  
  
  METHODS
  Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction (t0), at the beginning of laparoscopy (t1), and at the time of pneumoperitoneum 120 min (t2), pneumoperitoneum 240 min (t3), pneumoperitoneum 480 min (t4), the end of pneumoperitoneum (t5), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2 (rSO(2, %max)) was significantly higher in the POCD group than in the non-POCD group. The rSO(2, %max) value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values (P<0.01). After 24 h, levels of plasma Aβ in the POCD group were significantly higher than those in the non-POCD group (P<0.01).
  
  
  CONCLUSIONS
  The development of POCD in patients undergoing laparoscopic pancreaticoduodenectomy is associated with alterations of rSO2 and Aβ. Monitoring of rSO2 might be useful in the prediction of POCD, and Aβ might be used as a sensitive biochemical marker to predict the occurrence of POCD.
authors.affiliation: Department of Anesthesiology, Affiliated Qianfoshan Hospital of Shandong University, Jinan 250014, China; Department of Anesthesiology, Linyi City People's Hospital, Linyi 276000, China; Department of Emergency Surgery, Linyi City People's Hospital, Linyi 276000, China; Department of Anesthesiology, Shandong Lunan Ophthalmologic Hospital, Linyi 276000, China.
authors.forename: Xi-ming
authors.initials: XM
authors.lastname: Li
authors.forename: Ming-tao
authors.initials: MT
authors.lastname: Shao
authors.forename: Jian-juan
authors.initials: JJ
authors.lastname: Wang
authors.forename: Yue-lan
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010092:Oximetry / Q000379:methods; D010100:Oxygen / Q000032:analysis*; D016577:Pancreaticoduodenectomy / Q000009:adverse effects*; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010100:Oxygen
keywords: Laparoscopic pancreaticoduodenectomy; Post-operative cognitive dysfunction; Regional cerebral oxygen saturation; β-Amyloid protein