title: [Transmission and modulation of itch].
abstract: Chronic itch is an annoying and disabling symptom that severely affects patients' quality of life in several dermatological as well as non-dermatological disorders. Chronic itch may be maintained and even aggravated by sensitization of peripheral and central neuronal structures. The possibilities to effectively relieve chronic itch are often limited and the need of more specific, effective and quick-acting treatment options is huge. This review summarizes the fundamental aspects of itch, the neuronal transmission and modulation of itch, and discusses new treatment opportunities.
authors.affiliation: Dermato-venerologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV. E-mail: jelberling@dadlnet.dk.
authors.forename: Jesper
authors.initials: J
authors.lastname: Elberling
authors.forename: Lars
authors.initials: L
authors.lastname: Arendt-Nielsen
mesh_terms: D001921:Brain / Q000502:physiology; D002908:Chronic Disease; D006801:Humans; D011537:Pruritus / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011984:Sensory Receptor Cells / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology