title: [A case of advanced prostate fibrosarcoma that reacted well to chemotherapy].
abstract: Prostate fibrosarcoma is an extremely rare tumor for which complete excision has been the mainstay of treatment. Although chemotherapy has been attempted in cases with positive surgical margins and/or advanced stage disease, the effectiveness of this therapy has not been established. Herein, we report a case of advanced prostate fibrosarcoma that reacted well to chemotherapy. A 40-year-old man was referred for treatment of a large prostatic tumor with multiple lung, liver, and bone metastases. Needle biopsy of the prostate revealed that the tumor was a high-grade undifferentiated sarcoma. Chemotherapy with doxorubicin and ifosfamide was administered. After five courses of chemotherapy, the primary prostate tumor decreased markedly, and the lung and liver metastases almost disappeared. Radical cystoprostatectomy and ileal conduit formation were performed. Pathological diagnosis was fibrosarcoma. Another three courses of doxorubicin and ifosfamide therapy were performed, and doxorubicin was replaced by etoposide because the maximum dose of doxorubicin was reached. However, the effectiveness of the second-line therapy was poor, and the tumor progressed again. The patient died of lung metastasis 15 months later.
authors.affiliation: The Department of Urology, Shinshu University School of Medicine.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yokoyama
authors.affiliation: The Department of Urology, Shinshu University School of Medicine.
authors.forename: Tetsuichi
authors.initials: T
authors.lastname: Saito
authors.affiliation: The Department of Urology, Shinshu University School of Medicine.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamagishi
authors.affiliation: The Department of Urology, Shinshu University School of Medicine.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ogawa
authors.affiliation: The Department of Urology, Japanese Red Cross Society Suwa Hospital.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kurizaki
authors.affiliation: The Department of Urology, Nagano Municipal Hospital.
authors.forename: Haruaki
authors.initials: H
authors.lastname: Kato
authors.affiliation: The Department of Urology, Shinshu University School of Medicine.
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishizuka
authors.affiliation: Azumi General Hospital.
authors.forename: Osamu
authors.initials: O
authors.lastname: Nishizawa
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017809:Fatal Outcome; D005354:Fibrosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed