title: Serum annexin A2 levels in patients with colon cancer in comparison to healthy controls and in relation to tumor pathology.
abstract: BACKGROUND
  The deregulation and localization of the Annexins is consistently reported to have close relation to tumor cell malignancy, invasion, and metastasis as well as clinical progression of tumors. This study aimed to evaluate serum Annexin A2 (Anx A2) levels in patients with colon cancer in comparison to healthy controls and in relation to demographics and tumor pathology.
  
  
  METHODS
  A total of 100 patients (mean (SD) age: 58 (5.8) years, 55.0% females) with colon cancer and 70 controls (mean (SD) age: 59 (5.4) years, 50.0% females) were included. Serum levels for Anx A2 were evaluated in relation to study group, demographics, and tumor pathology.
  
  
  RESULTS
  Serum levels for Anx A2 were significantly lower in patients with colon cancer than in controls (13.1 (4.5) vs. 22.8 (2.1) ng/mL, p<0.001) and significantly decreased with increase in tumor size (p=0.003), and at higher stages of TNM (p=0.004), tumor invasion (p=0.005), lymph node metastasis (p=0.003), and distant metastasis (p=0.005).
  
  
  CONCLUSIONS
  Our findings indicate a significant decrease in Anx A2 expression in colon cancer patients compared to healthy controls and in parallel with tumor progression.
authors.affiliation: Department of General Surgery, Acibadem University School of Medicine, Istanbul, Turkey.
authors.forename: Ercument
authors.initials: E
authors.lastname: Gurluler
authors.affiliation: Clinic of General Surgery, Acibadem Bursa Hospital, Bursa, Turkey.
authors.forename: Osman Serhat
authors.initials: OS
authors.lastname: Guner
authors.affiliation: Clinic of General Surgery, Acibadem Bursa Hospital, Bursa, Turkey.
authors.forename: Latif Volkan
authors.initials: LV
authors.lastname: Tumay
authors.affiliation: Department of Internal Diseases, Acibadem University School of Medicine, Istanbul, Turkey.
authors.forename: Nurten
authors.initials: N
authors.lastname: Turkel Kucukmetin
authors.affiliation: Department of Clinic Laboratory, Acibadem Bursa Hospital, Bursa, Turkey.
authors.forename: Banu
authors.initials: B
authors.lastname: Hizli
authors.affiliation: Clinic of General Surgery, Acibadem Bursa Hospital, Bursa, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Zorluoglu
mesh_terms: D000328:Adult; D000368:Aged; D017306:Annexin A2 / Q000097:blood*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D017306:Annexin A2