title: Complete pathological response after FOLFIRINOX for locally advanced pancreatic cancer. The beginning of a new era? Case report and review of the literature.
abstract: Neoadjuvant treatments (chemo or chemoradiation therapy) are used for patients with locally advanced Pancreatic Ductal Adeno-Carcinoma (PDAC). FOLFIRINOX is now considered an effective treatment modality for patients with metastatic pancreatic cancer and a promising option for patients with locally advanced PDAC. Complete pathologic response after neoadjuvant therapies is anecdotic and its prognostic impact is completely unclear. We report the case of a complete pathological response after treatment with FOLFIRINOX in a patient affected by a locally advanced PDAC with a review of the literature regarding the use of FOLFIRINOX for locally advanced PDAC.
authors.affiliation: Unit of General Surgery, Campus Bio-Medico University of Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Valeri
authors.affiliation: Unit of General Surgery, Campus Bio-Medico University of Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Borzomati
authors.affiliation: Unit of General Surgery, Campus Bio-Medico University of Rome, Italy. Electronic address: g.nappo@unicampus.it.
authors.forename: G
authors.initials: G
authors.lastname: Nappo
authors.affiliation: Department of Pathology, Campus Bio-Medico University of Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Perrone
authors.affiliation: Unit of Medical Oncology, Campus Bio-Medico University of Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.affiliation: Unit of General Surgery, Campus Bio-Medico University of Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Coppola
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin
keywords: Complete pathological response; FOLFIRINOX; Locally advanced pancreatic cancer; Neoadjuvant chemotherapy; Neoadjuvant treatment; Pancreatic cancer