title: [Compared with colloidal silica and porous silica as baicalin solid dispersion carrier].
abstract: OBJECTIVE
  To compare the dissolution characteristics of colloidal silica and porous silica as the solid dispersion carrier, with baicalin as the model drug.
  
  
  METHODS
  The baicalin solid dispersion was prepared by the solvent method, with colloidal silica and porous silica as the carriers. In the in vitro dissolution experiment, the solid dispersion was identified by scanning electron microscopy, differential scanning and X-ray diffraction.
  
  
  RESULTS
  The solid dispersion carriers prepared with both colloidal silica and porous silica could achieve the purpose of rapid release. Along with the increase in the proportion of the carriers, the dissolution rate is accelerated to more than 80% within 60 min. Baicalin existed in the solid dispersion carriers in the non-crystalline form.
  
  
  CONCLUSIONS
  The release behaviors of the baicalin solid dispersion prepared with two types of carrier were different. Among the two solid dispersion carriers, porous silica dissolved slowly than colloidal silica within 60 min, and they showed similar dissolutions after 60 min.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yan
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Ding
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: E
authors.initials: E
authors.lastname: Sun
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
mesh_terms: D002152:Calorimetry, Differential Scanning; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility
chemical_list: D003102:Colloids; D004337:Drug Carriers; D005419:Flavonoids; C038044:baicalin; D012822:Silicon Dioxide