title: Exogenous Cushing syndrome: a lesson of diaper rash cream.
abstract: A prolonged use of topical corticosteroids can result in Cushing syndrome, though this is less common than with oral or parenteral steroids. Most pediatric cases were due to application of topical steroids for diaper dermatitis. Adverse cardiovascular effects can occur in Cushing syndrome with significant long-term morbidity and mortality, though so far there have been no reports of cardiovascular complications due to excessive usage of topical steroids. We report a 2.5-month-old boy who rapidly developed severe Cushing syndrome induced by the misuse of topical clobetasol, a very potent steroid, without a doctor's prescription as a diaper rash cream, and developed moderate left ventricular hypertrophy and pericardial effusion.
authors.affiliation: Khoo Teck Puat - National University Children's Medical Institute, National University Hospital, National University Health System, Singapore, Singapore.
authors.forename: Cindy Wei-Li
authors.initials: CW
authors.lastname: Ho
authors.forename: Kah Yin
authors.initials: KY
authors.lastname: Loke
authors.forename: Yvonne Yi-Juan
authors.initials: YY
authors.lastname: Lim
authors.forename: Yung Seng
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000287:Administration, Topical; D002990:Clobetasol / Q000008:administration & dosage* / Q000009:adverse effects*; D003480:Cushing Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D003963:Diaper Rash / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D012720:Severity of Illness Index; D063465:Skin Cream / Q000009:adverse effects
chemical_list: D002990:Clobetasol