title: Effects of magnesium and vitamin b6 on the severity of premenstrual syndrome symptoms.
abstract: BACKGROUND
  The importance of resolving the problem of premenstrual syndrome for patients has been emphasized due to its direct and indirect economical effects on the society. The aim of the current study was to evaluate the effects of magnesium and vitamin B6 on the severity of premenstrual syndrome in patients referring to health centers affiliated to Isfahan University of Medical Sciences, Iran, during 2009-10.
  
  
  METHODS
  This two-stage double-blind clinical trial was conducted on 126 women who were randomly allocated into 3 groups to receive magnesium, vitamin B6, or placebo. The study was performed in 10 selected health centers in Isfahan and lasted for 4 months. To confirm premenstrual syndrome, the participants were asked to complete a menstrual diary for 2 months at home. Drug interventions were continued for two cycles and the results of before and after the intervention were compared.
  
  
  RESULTS
  The findings of this study showed that the mean scores of premenstrual syndrome significantly decreased after the intervention in all groups (p < 0.05).
  
  
  CONCLUSIONS
  According to our findings, vitamin B6 and placebo had the most and least efficiency in improving the mean premenstrual syndrome score.
authors.affiliation: Islamic Azad University, Maragheh, Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Ebrahimi
authors.affiliation: Islamic Azad University, Maragheh, Iran.
authors.forename: Shiva
authors.initials: S
authors.lastname: Khayati Motlagh
authors.affiliation: Islamic Azad University, Maragheh, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Nemati
authors.affiliation: Islamic Azad University, Maragheh, Iran.
authors.forename: Zohreh
authors.initials: Z
authors.lastname: Tavakoli
keywords: Magnesium; Placebo; Premenstrual syndrome; Premenstrual tension; Vitamin B6