title: A comparison between the nephrotoxic profile of gentamicin and gentamicin nanoparticles in mice.
abstract: Aminoglycoside antibiotics are widely used against Gram-negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosides, finding new therapeutic strategies against this problem has a great clinical value. This study has attempted to compare the nephrotoxic properties of gentamicin and a new nanosized formulation of this drug in a mice model. Animals were treated with gentamicin (100 mg/kg, i.p. for eight consecutive days) and nanogentamicin (100 mg/kg, i.p. for eight consecutive days). Blood urea nitrogen (BUN), plasma creatinine levels, and histopathological changes of kidney proximal tubule were monitored. It was found that gentamicin caused severe degeneration of kidney proximal tubule cells and an increase in serum creatinine and BUN. No severe injury was observed after nanogentamicin administration. This study proved that nanosized gentamicin is less nephrotoxic.
authors.affiliation: Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Pharmacology and Toxicology Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Akram
authors.initials: A
authors.lastname: Jamshidzadeh
authors.forename: Reza
authors.initials: R
authors.lastname: Heidari
authors.forename: Soliman
authors.initials: S
authors.lastname: Mohammadi-Samani
authors.forename: Negar
authors.initials: N
authors.lastname: Azarpira
authors.forename: Asma
authors.initials: A
authors.lastname: Najbi
authors.forename: Parisa
authors.initials: P
authors.lastname: Jahani
authors.forename: Narges
authors.initials: N
authors.lastname: Abdoli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000494:pharmacology; D003404:Creatinine / Q000097:blood; D005839:Gentamicins / Q000009:adverse effects* / Q000494:pharmacology; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000009:adverse effects*; D014508:Urea / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014508:Urea; D003404:Creatinine
keywords: Aminoglycoside Antibiotic; Kidney Injury; Nano-drug; Nephrotoxicity; Renal Failure