title: Frontoparietal correlation dynamics reveal interplay between integration and segregation during visual working memory.
abstract: Working memory requires large-scale cooperation among widespread cortical and subcortical brain regions. Importantly, these processes must achieve an appropriate balance between functional integration and segregation, which are thought to be mediated by task-dependent spatiotemporal patterns of correlated activity. Here, we used cross-correlation analysis to estimate the incidence, magnitude, and relative phase angle of temporally correlated activity from simultaneous local field potential recordings in a network of prefrontal and posterior parietal cortical areas in monkeys performing an oculomotor, delayed match-to-sample task. We found long-range intraparietal and frontoparietal correlations that display a bimodal distribution of relative phase values, centered near 0° and 180°, suggesting a possible basis for functional segregation among distributed networks. Both short- and long-range correlations display striking task-dependent transitions in strength and relative phase, indicating that cognitive events are accompanied by robust changes in the pattern of temporal coordination across the frontoparietal network.
authors.affiliation: Cell Biology and Neuroscience, Montana State University, Bozeman, Montana 59717 nicholas.dotson@live.com.
authors.forename: Nicholas M
authors.identifier: http://orcid.org/0000-0002-0885-2182
authors.initials: NM
authors.lastname: Dotson
authors.affiliation: Cell Biology and Neuroscience, Montana State University, Bozeman, Montana 59717.
authors.forename: Rodrigo F
authors.identifier: http://orcid.org/0000-0003-3530-666X
authors.initials: RF
authors.lastname: Salazar
authors.affiliation: Cell Biology and Neuroscience, Montana State University, Bozeman, Montana 59717.
authors.forename: Charles M
authors.initials: CM
authors.lastname: Gray
mesh_terms: D000818:Animals; D005074:Evoked Potentials, Visual / Q000502:physiology; D005133:Eye Movements / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D008253:Macaca mulatta; D008570:Memory, Short-Term / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*
keywords: electrophysiology; frontoparietal; monkey; oscillations; synchrony; working memory