title: The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
abstract: Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or trials with flaws in experimental methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay people the groundwork for this matter.
authors.forename: Alberto
authors.initials: A
authors.lastname: Consolaro
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000209:etiology; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001851:Bone Diseases, Metabolic / Q000188:drug therapy; D016723:Bone Remodeling / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects; D000075202:Contraindications; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use*; D055094:Evidence-Based Dentistry; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced; D020360:Neoadjuvant Therapy; D009369:Neoplasms / Q000628:therapy; D009971:Orthodontics, Corrective; D010010:Osteoclasts / Q000187:drug effects; D010019:Osteomyelitis / Q000139:chemically induced; D010024:Osteoporosis / Q000188:drug therapy
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates
keywords: Bisphosphonates; Implants; Orthodontics; Osteomyelitis; Osteonecrosis