title: Charge dependent photodynamic activity of alanine based zinc phthalocyanines.
abstract: In this paper, to minimize the effects of different structure, three alanine-based zinc phthalocyanines (Pcs) of differing charges were engineered and synthesized with the same basic structure. On this premise, the relationship between nature of charge and photodynamic activity was studied. Besides, further verification and explanation of some inconsistent results were also carried out. The results showed that charge can influence the aggregation state, singlet oxygen generation ability and cellular uptake of Pcs, thereby affecting their photodynamic activity. In addition, the biomolecules inside cells may interact with Pcs of differing charges, which can also influence the aggregation state and singlet oxygen generation of the Pcs, and then influence the relationship between nature of charge and photodynamic activity.
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Ao
authors.initials: A
authors.lastname: Wang
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Yejing
authors.initials: Y
authors.lastname: Li
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Linxin
authors.initials: L
authors.lastname: Yuan
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Shan
authors.initials: S
authors.lastname: Lu
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China.
authors.forename: Jiahong
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210046, PR China. Electronic address: shwei@njnu.edu.cn.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Wei
mesh_terms: D000409:Alanine / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D054833:Isoindoles; D008027:Light; D008856:Microscopy, Fluorescence; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D010782:Photolysis / Q000187:drug effects / Q000528:radiation effects; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000378:metabolism / Q000633:toxicity; D026082:Singlet Oxygen / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D017967:Zinc Compounds
chemical_list: D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; D026082:Singlet Oxygen; D000409:Alanine
keywords: Aggregation state; Alanine based zinc phthalocyanine; Charge; Photodynamic activity; Photosensitizer; Singlet oxygen