title: Cherubism with multiple dental abnormalities: a rare presentation.
abstract: Cherubism is a progressive, hereditary fibro-osseous lesion exclusively affecting the jaw bones. It is caused by the abnormal functioning of osteoblasts and osteoclasts, leading to replacement of normal bone by cellular fibrous tissue and immature bone, which produces painless progressive growth of the jaw, with a round facial appearance. It was first described in 1933 by Jones as 'familial multilocular cystic disease of the jaws'. The term 'cherubism' was later coined to describe the rounded facial appearance resulting from jaw hypertrophy that was reminiscent of cherubs depicted throughout Renaissance art. The bony lesions generally occur at an early age, affect one or both jaws symmetrically, and grow progressively until puberty. Spontaneous regression is seen in most cases, although surgical re-contouring may be required for others for aesthetic reasons.
authors.affiliation: Department of Oral Medicine and Radiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Satya Ranjan
authors.initials: SR
authors.lastname: Misra
authors.affiliation: Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Lora
authors.initials: L
authors.lastname: Mishra
authors.affiliation: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Neeta
authors.initials: N
authors.lastname: Mohanty
authors.affiliation: Department of Paediatric Dentistry, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors.forename: Susant
authors.initials: S
authors.lastname: Mohanty
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D000293:Adolescent; D002636:Cherubism / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D008297:Male; D008334:Mandible / Q000473:pathology*; D011627:Puberty; D014070:Tooth / Q000473:pathology*