title: Polymer-free amphilimus-eluting stents in patients with diabetes mellitus.
abstract: Despite several improvements in drug-eluting stents design, diabetes mellitus (DM) remains an Achilles' heel for percutaneous coronary revascularization at the present time. The Cre8 stent is a third-generation drug-eluting stent devoid of polymer. The drug, which is formulated with an amphiphilic carrier, is eluted from laser-dug wells on the stent's abluminal surface. The Cre8 stent hat has shown promising preliminary results in patients with DM. This review summarizes the mechanisms of DES failure in patients with DM and the potential role of the Cre8 stent in this high-risk population.
authors.affiliation: Heart Diseases Institute Hospital de Bellvitge‑IDIBELL University of Barcelona, Barcelona, Spain - rafaromaguera@gmail.com.
authors.forename: R
authors.initials: R
authors.lastname: Romaguera
authors.forename: J
authors.initials: J
authors.lastname: Gómez-Lara
authors.forename: F
authors.initials: F
authors.lastname: Jacobi
authors.forename: J A
authors.initials: JA
authors.lastname: Gomez-Hospital
authors.forename: A
authors.initials: A
authors.lastname: Cequier
mesh_terms: D003920:Diabetes Mellitus / Q000503:physiopathology*; D054855:Drug-Eluting Stents; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods; D011474:Prosthesis Design; D011475:Prosthesis Failure; D020123:Sirolimus / Q000008:administration & dosage
chemical_list: D020123:Sirolimus