title: Pd- and Cu-catalyzed stereo- and regiocontrolled decarboxylative/C-H fluoroalkenylation of heteroarenes.
abstract: Pd/Cu-catalyzed decarboxylative/direct C-H alkenylations of heteroarenes with α-fluoroacrylic acid is reported. This method offers step-economical and stereocontrolled access to valuable heteroarylated monofluoroalkenes as both Z and E isomers, which are known to be useful in the synthesis of fluorinated biomolecules.
authors.affiliation: Normandie Univ, COBRA, UMR 6014 et FR 3038; Univ Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesnière 76821 Mont-Saint-Aignan Cedex (France).
authors.forename: Kevin
authors.initials: K
authors.lastname: Rousée
authors.forename: Cédric
authors.initials: C
authors.lastname: Schneider
authors.forename: Samuel
authors.initials: S
authors.lastname: Couve-Bonnaire
authors.forename: Xavier
authors.initials: X
authors.lastname: Pannecoucke
authors.forename: Vincent
authors.initials: V
authors.lastname: Levacher
authors.forename: Christophe
authors.initials: C
authors.lastname: Hoarau
keywords: CH activation; alkenylation; decarboxylation; fluoroalkenes; heterocycles; palladium