title: Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis.
abstract: This review summarizes the mechanisms that control the activity of the c-Myb transcription factor in normal cells and tumors, and discusses how c-Myb plays a role in the regulation of the cell cycle. Oncogenic versions of c-Myb contribute to the development of leukemias and solid tumors such as adenoid cystic carcinoma, breast cancer and colon cancer. The activity and specificity of the c-Myb protein seems to be controlled through changes in protein-protein interactions, so understanding how it is regulated could lead to the development of novel therapeutic strategies.
authors.affiliation: Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025-CRF 121, 1 University of New Mexico, Albuquerque, NM 87131, USA. ogeorge@hawaii.edu.
authors.forename: Olivia L
authors.initials: OL
authors.lastname: George
authors.affiliation: Department of Internal Medicine, Section of Molecular Medicine, University of New Mexico Health Sciences Center, MSC07 4025-CRF 121, 1 University of New Mexico, Albuquerque, NM 87131, USA. sness@salud.unm.edu.
authors.forename: Scott A
authors.initials: SA
authors.lastname: Ness