title: A modular phosphate tether-mediated divergent strategy to complex polyols.
abstract: An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple "order of addition" of a pair of olefinic-alcohol components to a pseudo-C 2-symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Susanthi
authors.initials: S
authors.lastname: Jayasinghe
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Soma
authors.initials: S
authors.lastname: Maitra
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Cornelius N
authors.initials: CN
authors.lastname: Ndi
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, KS 66045-7582, USA.
authors.forename: Rambabu
authors.initials: R
authors.lastname: Chegondi
keywords: one-pot; organophosphorus; phosphate-tether; polyol; sequential processes; stereodivergent