title: High-dose-rate brachytherapy for vaginal rhabdomyosarcoma using a personalized mold in a 20-month old patient.
abstract: Treatment of vaginal rhabdomyosarcoma (RMS) with conservative approaches is presently the standard of care. Intravaginal high-dose rate brachytherapy is a very effective treatment while sparing the normal tissue to preserve growth, fertility and prevent organ dysfunction. In this report, we describe the management of an infant with Stage I vaginal RMS, treated with chemotherapy, maximal safe resection and intravaginal brachytherapy using a customized mold and MRI and CT-based three-dimensional (3D) conformal planning, followed by a critical review of the literature.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.
authors.forename: Lara
authors.initials: L
authors.lastname: Hathout
authors.forename: Jamie
authors.initials: J
authors.lastname: Cohn
authors.forename: Laszlo
authors.initials: L
authors.lastname: Voros
authors.forename: Sae Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Todd
authors.initials: T
authors.lastname: Heaton
authors.forename: Suzanne
authors.initials: S
authors.lastname: Wolden
mesh_terms: D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D007223:Infant; D057285:Precision Medicine / Q000295:instrumentation / Q000379:methods; D012208:Rhabdomyosarcoma / Q000473:pathology / Q000532:radiotherapy*; D014625:Vaginal Neoplasms / Q000473:pathology / Q000532:radiotherapy*
keywords: radiation oncology; radiation therapy; rhabdomyosarcoma