title: The effect of medicaments used in endodontic regeneration technique on the dislocation resistance of mineral trioxide aggregate to root canal dentin.
abstract: BACKGROUND
  The aim of this study was to evaluate the effect of calcium hydroxide (CH) and antibiotic pastes, including a mixture of metronidazole and ciprofloxacin, with and without minocycline or cefaclor, on the dislocation resistance of mineral trioxide aggregate (MTA) to root dentin.
  
  
  METHODS
  Eighty single-rooted human mandibular premolars were selected. The teeth were prepared by using the ProTaper system. The prepared teeth were then instrumented to a #6 Peeso reamer to obtain a standard internal diameter of 1.5 mm. The reamers were passed 1 mm beyond apex to simulate immature teeth. The specimens were then randomly divided into a control group (no intracanal medicament was used) and 4 experimental groups that were treated with an intracanal medicament: CH, double antibiotic paste (DAP) with metronidazole and ciprofloxacin, triple antibiotic paste (TAP) with minocycline, or TAP with cefaclor (n = 16). After 3 weeks, the medicaments were removed, and approximately 3 mm of MTA was placed in the coronal third of the canals. A push-out test was used to measure the dislocation resistance between the root dentin and MTA. Data were analyzed by using one-way analysis of variance and Tukey post hoc tests.
  
  
  RESULTS
  The dislocation resistance values of the CH, TAP with minocycline, and TAP with cefaclor groups were similar to those of the control group (P > .05), whereas the DAP group had the lowest dislocation resistance when compared with the other groups (P < .05). Overall, there was a predominance of cohesive failures between root dentin and MTA.
  
  
  CONCLUSIONS
  The results of this study indicate that the application of DAP as an intracanal medicament reduced the dislocation resistance of MTA to root dentin.
authors.affiliation: Faculty of Dentistry, Department of Endodontics, Erciyes University, Kayseri, Turkey. Electronic address: topcuogluhs@hotmail.com.
authors.forename: Hüseyin Sinan
authors.initials: HS
authors.lastname: Topçuoğlu
authors.affiliation: Faculty of Dentistry, Department of Endodontics, Ataturk University, Erzurum, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Arslan
authors.affiliation: Faculty of Dentistry, Department of Pedodontics, Katip Çelebi University, Izmir, Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Akçay
authors.affiliation: Faculty of Dentistry, Department of Endodontics, Katip Çelebi University, Izmir, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Saygili
authors.affiliation: Faculty of Dentistry, Department of Endodontics, Ordu University, Ordu, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Çakici
authors.affiliation: Faculty of Dentistry, Department of Pedodontics, Erciyes University, Kayseri, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Topçuoğlu
mesh_terms: D000268:Adhesiveness; D017607:Aluminum Compounds / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry*; D002126:Calcium Hydroxide / Q000737:chemistry; D002433:Cefaclor / Q000737:chemistry; D002939:Ciprofloxacin / Q000737:chemistry; D001840:Dental Bonding; D003786:Dental Pulp Cavity / Q000648:ultrastructure*; D003804:Dentin / Q000648:ultrastructure*; D004338:Drug Combinations; D006801:Humans; D008422:Materials Testing; D008795:Metronidazole / Q000737:chemistry; D008911:Minocycline / Q000737:chemistry; D010087:Oxides / Q000737:chemistry*; D011897:Random Allocation; D012388:Root Canal Irrigants / Q000737:chemistry*; D018915:Root Canal Preparation / Q000379:methods; D017640:Silicates / Q000737:chemistry*; D012973:Sodium Hypochlorite / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties
chemical_list: D017607:Aluminum Compounds; D000900:Anti-Bacterial Agents; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012388:Root Canal Irrigants; D017640:Silicates; C086631:mineral trioxide aggregate; D008795:Metronidazole; D002939:Ciprofloxacin; D002433:Cefaclor; D012973:Sodium Hypochlorite; D008911:Minocycline; D002126:Calcium Hydroxide
keywords: Dislocation resistance; medicament; mineral trioxide aggregate