title: Large scale in vivo recordings to study neuronal biophysics.
abstract: Over the last several years, technological advances have enabled researchers to more readily observe single-cell membrane biophysics in awake, behaving animals. Studies utilizing these technologies have provided important insights into the mechanisms generating functional neural codes in both sensory and non-sensory cortical circuits. Crucial for a deeper understanding of how membrane biophysics control circuit dynamics however, is a continued effort to move toward large scale studies of membrane biophysics, in terms of the numbers of neurons and ion channels examined. Future work faces a number of theoretical and technical challenges on this front but recent technological developments hold great promise for a larger scale understanding of how membrane biophysics contribute to circuit coding and computation.
authors.affiliation: Department of Neurobiology, Stanford University School of Medicine, 299 Campus Drive, Stanford, CA 94305, United States. Electronic address: giocomo@stanford.edu.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Giocomo
mesh_terms: D000818:Animals; D001703:Biophysics / Q000379:methods*; D002462:Cell Membrane / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008954:Models, Biological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*
chemical_list: D007473:Ion Channels