title: Finding my own way: an fMRI single case study of a subject with developmental topographical disorientation.
abstract: Developmental topographical disorientation (DTD) causes impaired spatial orientation and navigation from early childhood with no evidence of cerebral damage. Using fMRI and a landmark sequencing task, we investigated the hypothesis that Dr Wai's abnormal cerebral activation pattern was related to his peculiar behavioral profile. Although Dr Wai was able to correctly perform landmark sequencing, he showed a lack of activity in regions activated in all control subjects and activity in areas that were not activated in any control subject. These results are discussed in light of cognitive and functional model of navigation, with relevant implications for DTD physiology.
authors.affiliation: a Neuropsychology Unit , Santa Lucia Foundation , Rome , Italy.
authors.forename: Federico
authors.initials: F
authors.lastname: Nemmi
authors.forename: Filippo
authors.initials: F
authors.lastname: Bianchini
authors.forename: Federica
authors.initials: F
authors.lastname: Piras
authors.forename: Patrice
authors.initials: P
authors.lastname: Péran
authors.forename: Liana
authors.initials: L
authors.lastname: Palermo
authors.forename: Laura
authors.initials: L
authors.lastname: Piccardi
authors.forename: Umberto
authors.initials: U
authors.lastname: Sabatini
authors.forename: Cecilia
authors.initials: C
authors.lastname: Guariglia
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology*; D065854:Spatial Navigation / Q000502:physiology*; D065855:Spatial Processing / Q000502:physiology*; D055815:Young Adult
keywords: developmental topographical disorientation; fMRI; landmark knowledge; spatial navigation