title: Brd4 is on the move during inflammation.
abstract: Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.
authors.affiliation: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA; Molecular and Cellular Biology Program, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address: vakoc@cshl.edu.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Vakoc
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D052002:NF-kappa B p50 Subunit / Q000276:immunology*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D051996:Transcription Factor RelA / Q000276:immunology*; D014157:Transcription Factors / Q000037:antagonists & inhibitors*
chemical_list: D052002:NF-kappa B p50 Subunit; D009687:Nuclear Proteins; D051996:Transcription Factor RelA; D014157:Transcription Factors
keywords: BET bromodomain; Brd4; JQ1; NF-kB; enhancer; inflammation; p65; super-enhancer