title: Autoantibodies to neurofascin-186 and gliomedin in multifocal motor neuropathy.
abstract: We tested autoantibodies to neurofascin-186 (NF186) and gliomedin in sera from patients with multifocal motor neuropathy (MMN, n=53) and chronic inflammatory demyelinating polyneuropathy (CIDP, n=95) by ELISA. IgG antibodies to NF186 or gliomedin were found in 62% of MMN and 1% of CIDP sera, and IgM antibodies to the same antigens in 12% of MMN and 1% of CIDP sera. These autoantibodies activated complement. Ten percent of the MMN sera without IgM anti-GM1 reactivity had anti-NF186 antibodies. Because NF186 and gliomedin play a crucial role for salutatory conduction, the autoantibodies may contribute to produce motor nerve conduction block and muscle weakness in MMN.
authors.affiliation: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti-Pescara, Italy. Electronic address: francnotturno@yahoo.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Notturno
authors.affiliation: Experimental Zooprophylactic Institute of Abruzzo and Molise "G. Caporale", Teramo, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Di Febo
authors.affiliation: Department of Medicine, National University of Singapore, Singapore; Department of Physiology, National University of Singapore, Singapore.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
authors.affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland.
authors.forename: Blanca M
authors.initials: BM
authors.lastname: Fernandez Rodriguez
authors.affiliation: Institute for Research in Biomedicine, Bellinzona, Switzerland.
authors.forename: Davide
authors.initials: D
authors.lastname: Corti
authors.affiliation: 2nd Neurology, Department of Medical Biotechnology and Translational Medicine, IRCCS Humanitas Clinical Institute, Milan University, Rozzano, Milan, Italy.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Nobile-Orazio
authors.affiliation: Neurology Unit, Ospedale Treviglio, Bergamo, Italy.
authors.forename: Marinella
authors.initials: M
authors.lastname: Carpo
authors.affiliation: Department of Respiratory Medicine, Catholic University, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: De Lauretis
authors.affiliation: Department of Neuroscience and Imaging, University "G. d'Annunzio", Chieti-Pescara, Italy.
authors.forename: Antonino
authors.initials: A
authors.lastname: Uncini
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology*; D019295:Computational Biology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005677:G(M1) Ganglioside / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D016472:Motor Neuron Disease / Q000097:blood* / Q000150:complications; D009414:Nerve Growth Factors / Q000235:genetics / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000276:immunology*; D011115:Polyneuropathies / Q000097:blood* / Q000150:complications; D020033:Protein Isoforms / Q000276:immunology; D051381:Rats; D014162:Transfection
chemical_list: D001323:Autoantibodies; D015815:Cell Adhesion Molecules; C473138:GLDN protein, human; D008565:Membrane Proteins; C054305:NFASC protein, human; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D005677:G(M1) Ganglioside
keywords: Chronic inflammatory demyelinating neuropathy; Gliomedin; Multifocal motor neuropathy; Neurofascin