title: Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats.
abstract: The aim of this study is to investigate the role of FGF21 in obesity-related inflammation in livers of monosodium glutamate (MSG)-induced obesity rats. The MSG rats were injected with recombinant murine fibroblast growth factor 21(FGF21) or equal volumes of vehicle. Metabolic parameters including body weight, Lee's index, food intake, visceral fat and liver weight, intraperitoneal glucose tolerance, glucose, and lipid levels were dynamically measured at specific time points. Liver function and routine blood test were also analyzed. Further, systemic inflammatory cytokines such as glucose transporter 1 (GLUT-1), leptin, TNF-α, and IL-6 mRNAs were determined by real-time PCR. FGF21 independently decreased body weight and whole-body fat mass without reducing food intake in the MSG rats. FGF21 reduced blood glucose level, Lee's index, visceral fat, and liver weight, and improved glucose tolerance, lipid metabolic spectrum, and hepatic steatosis in the MSG-obesity rats. Liver function parameters including AST, ALT, ALP, TP, T.Bili, and D.Bili levels significantly reduced in the FGF21-treated obesity rats compared to the controls. Further, FGF21 ameliorated the total and differential white blood cell (WBC) count, serum C-reactive protein (CRP), IL-6, and TNF-α levels in adipose tissues of the obesity rats, suggesting inflammation amelioration in the in the obesity rats by FGF21. FGF21 improves multiple metabolic disorders and ameliorates obesity-related inflammation in the MSG-induced obesity rats.
authors.affiliation: College of Life Science, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, Harbin, 150030, China.
authors.forename: Wen-Fei
authors.initials: WF
authors.lastname: Wang
authors.forename: Si-Ming
authors.initials: SM
authors.lastname: Li
authors.forename: Gui-Ping
authors.initials: GP
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Zheng
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Lu
authors.forename: Yin-Hang
authors.initials: YH
authors.lastname: Yu
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Xu
authors.forename: Tian-He
authors.initials: TH
authors.lastname: Li
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: De-Shan
authors.initials: DS
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004195:Disease Models, Animal; D005234:Fatty Liver / Q000139:chemically induced / Q000188:drug therapy*; D005346:Fibroblast Growth Factors / Q000494:pharmacology*; D005421:Flavoring Agents / Q000494:pharmacology*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D050356:Lipid Metabolism / Q000187:drug effects*; D051379:Mice; D009765:Obesity / Q000139:chemically induced / Q000188:drug therapy*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012970:Sodium Glutamate / Q000494:pharmacology
chemical_list: D005421:Flavoring Agents; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D012970:Sodium Glutamate