title: The impact of autonomic dysfunction on peri-operative cardiovascular complications.
abstract: Cardiovascular autonomic neuropathy is frequently observed in patients with diabetes mellitus. As anaesthesia has a marked effect on peri-operative autonomic function, the interplay between diabetic neuropathy and anaesthesia may result in unexpected haemodynamic instability during surgery. The objective of this literature review was to examine the association of cardiovascular autonomic neuropathy with peri-operative cardiovascular complications. We searched PubMed for articles with search elements of autonomic dysfunction [MeSH] AND anaesthesia [MeSH] AND complications [MeSH]. Depending on the type of anaesthesia, the presence of cardiovascular autonomic neuropathy in surgical patients can markedly affect peri-operative haemodynamics and postoperative recovery. Pre-operative testing of the extent of autonomic dysfunction in particular populations, like diabetics, may contribute to a reduction in haemodynamic instability and cardiovascular complications. Non-invasive diagnostic methods assessing autonomic function may be an important tool during pre-operative risk assessment.
authors.affiliation: Department of Anaesthesiology, Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Lankhorst
authors.forename: S W M
authors.initials: SW
authors.lastname: Keet
authors.forename: C S E
authors.initials: CS
authors.lastname: Bulte
authors.forename: C
authors.initials: C
authors.lastname: Boer
mesh_terms: D000758:Anesthesia / Q000009:adverse effects; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000150:complications / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007431:Intraoperative Complications / Q000503:physiopathology*; D011183:Postoperative Complications / Q000503:physiopathology*; D012307:Risk Factors