title: Structure–activity relationship of terpenes with anti-inflammatory profile – a systematic review.
abstract: Inflammation is a complex biological response that in spite of having available treatments, their side effects limit their usefulness. Because of this, natural products have been the subject of incessant studies, among which the class of terpenes stands out. They have been the source of study for the development of anti-inflammatory drugs, once their chemical diversity is well suited to provide skeleton for future anti-inflammatory drugs. This systematic review reports the studies present in the literature that evaluate the anti-inflammatory activity of terpenes suffering any change in their structures, assessing whether these changes also brought changes in their effects. The search terms anti-inflammatory agents, terpenes, and structure–activity relationship were used to retrieve English language articles in SCOPUS, PUBMED and EMBASE published between January 2002 and August 2013. Twenty-seven papers were found concerning the structural modification of terpenes with the evaluation of antiinflammatory activity. The data reviewed here suggest that modified terpenes are an interesting tool for the development of new anti-inflammatory drugs.
authors.forename: Marilia Trindade de Santana
authors.initials: MT
authors.lastname: Souza
authors.forename: Jackson Roberto Guedes da Silva
authors.initials: JR
authors.lastname: Almeida
authors.forename: Adriano Antunes de Souza
authors.initials: AA
authors.lastname: Araujo
authors.forename: Marcelo Cavalcante
authors.initials: MC
authors.lastname: Duarte
authors.forename: Daniel Pens
authors.initials: DP
authors.lastname: Gelain
authors.forename: José Cláudio Fonseca
authors.initials: JC
authors.lastname: Moreira
authors.forename: Marcio Roberto Viana
authors.initials: MR
authors.lastname: dos Santos
authors.forename: Lucindo José
authors.initials: LJ
authors.lastname: Quintans-Júnior
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016208:Databases, Factual; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D013729:Terpenes