title: Stromal-dependent tumor promotion by MIF family members.
abstract: Solid tumors are composed of a heterogeneous population of cells that interact with each other and with soluble and insoluble factors that, when combined, strongly influence the relative proliferation, differentiation, motility, matrix remodeling, metabolism and microvessel density of malignant lesions. One family of soluble factors that is becoming increasingly associated with pro-tumoral phenotypes within tumor microenvironments is that of the migration inhibitory factor family which includes its namesake, MIF, and its only known family member, D-dopachrome tautomerase (D-DT). This review seeks to highlight our current understanding of the relative contributions of a variety of immune and non-immune tumor stromal cell populations and, within those contexts, will summarize the literature associated with MIF and/or D-DT.
authors.affiliation: JG Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, United States. Electronic address: robert.mitchell@louisville.edu.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Mitchell
authors.affiliation: JG Brown Cancer Center, Department of Medicine, University of Louisville, Louisville, KY 40202, United States.
authors.forename: Kavitha
authors.initials: K
authors.lastname: Yaddanapudi
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000378:metabolism; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D017154:Stromal Cells / Q000201:enzymology / Q000473:pathology
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C042501:dopachrome isomerase
keywords: Cancer; D-DT; Hypoxia; MIF; Stroma; Tumor microenvironment