title: Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil.
abstract: Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk [rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41]. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity.
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: C M A R
authors.initials: CM
authors.lastname: Barros
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: A P
authors.initials: AP
authors.lastname: Araujo-Neto
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: T R
authors.initials: TR
authors.lastname: Lopes
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: M A L
authors.initials: MA
authors.lastname: Barros
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: F J N
authors.initials: FJ
authors.lastname: Motta
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: R
authors.initials: R
authors.lastname: Canalle
authors.affiliation: Núcleo de Tecnologia Farmacêutica, Universidade Federal do Piauí, Teresina, PI, Brasil.
authors.forename: L C C
authors.initials: LC
authors.lastname: Nunes
authors.affiliation: Laboratorio de Oncogenética Molecular, Departamento de Cirugía Experimental, Hospital Universitario "La Paz", Madrid, España.
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
authors.affiliation: Laboratório de Citogenética Humana, Universidade Federal do Pará, Belém, PA, Brasil.
authors.forename: R R
authors.initials: RR
authors.lastname: Burbano
authors.affiliation: Tec Lab Medicina Laboratorial, Parnaíba, PI, Brasil.
authors.forename: M A
authors.initials: MA
authors.lastname: Lima-Barros
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil.
authors.forename: F K N
authors.initials: FK
authors.lastname: Yoshioka
authors.affiliation: Laboratório de Genética e Biologia Molecular, Universidade Federal do Piauí, Parnaíba, PI, Brasil pintogr@ufpi.edu.br.
authors.forename: G R
authors.initials: GR
authors.lastname: Pinto
mesh_terms: D001483:Base Sequence; D001938:Brazil; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: D017931:DNA Primers; C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein