title: Therapeutic effects of metformin and laparoscopic ovarian drilling in treatment of clomiphene and insulin-resistant polycystic ovary syndrome.
abstract: OBJECTIVE
  To compare the therapeutic effects of metformin (Met) and laparoscopic ovarian drilling (LOD) in clomiphene and insulin-resistant patients with polycystic ovary syndrome (CIRPCOS).
  
  
  METHODS
  A total of 110 patients were randomly divided into two groups. One group was administered Met (n = 55), while the other group underwent LOD (n = 55). Rates of ovulation, pregnancy, and abortion were compared between both groups.
  
  
  RESULTS
  Rates of normal menstruation, ovulation, and pregnancy in the LOD group were higher than in the Met group: 76.4% (42/55) vs. 58.2% (32/55), P < 0.04; 50.8% (11/258) vs. 33.5% (94/281), P < 0.001; 38.2% (21/55) vs. 20.0% (11/55), P < 0.03. The difference in the early abortion rate between both groups was not statistically significant.
  
  
  CONCLUSIONS
  Although Met can significantly improve a patient's insulin resistance, we found that in patients diagnosed with CIRCPOS, LOD can be much more effective in improving rates of normal menstruation, ovulation, and pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, 101st Hospital of PLA, Wuxi, 214044, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Huang
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D010535:Laparoscopy; D008687:Metformin / Q000627:therapeutic use*; D010060:Ovulation; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy* / Q000601:surgery*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D002996:Clomiphene; D008687:Metformin