title: Comparative gene expression profiling of normal and human colorectal adenomatous tissues.
abstract: Adenomatous colorectal polyps are the precursors of the majority of colorectal cancers. Investigation into the gene expression changes in the progression of colorectal adenoma may offer potential targets for the development of novel diagnostic strategies. Previous gene expression studies have generally been based on a limited number of cases or only focused on a single or a few genes. The present study aimed to identify molecular characteristics of colorectal adenoma through analysis of pathways and gene ontology. The study identified 808 upregulated and 857 downregulated genes. Among the 40 pathways enriched with differentially-expressed genes, theStaphylococcus aureusinfection pathway and the intestinal immune network for immunoglobulin A production pathway were identified as the most statistically noteworthy pathways at the early stage for colorectal tumorigenesis (P<0.05). These results provide new understanding of colorectal adenoma pathogenesis, with the hope of offering theoretical support for future therapeutic studies.
authors.affiliation: Department of Emergency Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Gongliang
authors.initials: G
authors.lastname: DU
authors.affiliation: Department of Emergency Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Xuehong
authors.initials: X
authors.lastname: Fang
authors.affiliation: Department of Emergency Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Dai
authors.affiliation: Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Ruipeng
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Ruiting
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China.
authors.forename: Xingbo
authors.initials: X
authors.lastname: Dang
keywords: colorectal adenoma; gene expression; gene ontology; pathway