title: Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates.
abstract: The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.
authors.affiliation: Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ambler
authors.affiliation: Department of Pharmacy, Birla Institute of Technology & Science, Pilani - Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, 500078 Andhra Pradesh, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Peddi
authors.affiliation: Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Altman
keywords: alkynes; catalysis; copper; decarboxylation; trifluoromethylation