title: Production and characterization of cornstarch/cellulose acetate/silver sulfadiazine extrudate matrices.
abstract: The production and evaluation of cornstarch/cellulose acetate/silver sulfadiazine extrudate matrices are reported herein. The matrices were melt extruded under nine different conditions, altering the temperature and the screw speed values. The surface morphology of the matrices was examined by scanning electron microscopy. The micrographs revealed the presence of non-melted silver sulfadiazine microparticles in the matrices extruded at lower temperature and screw speed values. The thermal properties were evaluated and the results for both the biopolymer and the drug indicated no thermal degradation during the melt extrusion process. The differential scanning analysis of the extrudate matrices showed a shift to lower temperatures for the silver sulfadiazine melting point compared with the non-extruded drug. The starch/cellulose acetate matrices containing silver sulfadiazine demonstrated significant inhibition of the growth of Pseudomonas aeruginosa and Staphylococcus aureus. In vivo inflammatory response tests showed that the extrudate matrices, with or without silver sulfadiazine, did not trigger chronic inflammatory processes.
authors.affiliation: CIMJECT, Departamento de Engenharia Mecânica, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil; TECFARMA, Universidade do Sul de Santa Catarina, 88704-900 Tubarão, SC, Brazil.
authors.forename: Karine Modolon
authors.initials: KM
authors.lastname: Zepon
authors.affiliation: FICEXP, Universidade do Sul de Santa Catarina, 88704-900 Tubarão, SC, Brazil.
authors.forename: Fabricia
authors.initials: F
authors.lastname: Petronilho
authors.affiliation: POLIMAT, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors.forename: Valdir
authors.initials: V
authors.lastname: Soldi
authors.affiliation: CIMJECT, Departamento de Engenharia Mecânica, Universidade Federal de Santa Catarina, 88040-900 Florianópolis, SC, Brazil.
authors.forename: Gean Vitor
authors.initials: GV
authors.lastname: Salmoria
authors.affiliation: TECFARMA, Universidade do Sul de Santa Catarina, 88704-900 Tubarão, SC, Brazil. Electronic address: luiz.kanis@unisul.br.
authors.forename: Luiz Alberto
authors.initials: LA
authors.lastname: Kanis
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013213:Starch / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D015850:Interleukin-6; D016753:Interleukin-10; C005062:acetylcellulose; D002482:Cellulose; D013213:Starch; D012837:Silver Sulfadiazine
keywords: Cornstarch/cellulose acetate; Extrudate matrices; Silver sulfadiazine