title: Association of surfactant protein B gene with chronic obstructive pulmonary disease susceptibility.
abstract: METHODS
  Genetic predisposition, in addition to smoking, is known to play a key role in susceptibility to chronic obstructive pulmonary disease (COPD). Several candidate genes have been proposed for COPD, including surfactant protein B (SFTPB). However, large studies in populations with different ethnic backgrounds and environments are required to clarify the role of SFTPB in COPD.
  
  
  OBJECTIVE
  We investigated the association of SFTPB polymorphisms with COPD susceptibility and lung function in a Chinese Han population.
  
  
  METHODS
  Four single nucleotide polymorphisms (SNPs) in the SFTPB gene were genotyped in 680 COPD patients and 687 controls. Allele frequencies and genotype distributions were compared between cases and controls and the potential relationships between these SNPs and lung function were investigated. Associations between haplotypes and COPD susceptibility were also assessed.
  
  
  RESULTS
  The SFTPB exon polymorphism rs1130866 significantly protected subjects from COPD (adjusted P = 0.004) and was associated with an increase in forced expiratory volume in 1 s (FEV(1)) (adjusted P = 0.014).
  
  
  CONCLUSIONS
  SFTPB variants are associated with COPD susceptibility and lung function in the Chinese Han population.
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: H-X
authors.initials: HX
authors.lastname: Zhou
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: B-M
authors.initials: BM
authors.lastname: Liang
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: C-L
authors.initials: CL
authors.lastname: Ma
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Xiao
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: J
authors.initials: J
authors.lastname: Deng
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: L
authors.initials: L
authors.lastname: Yan
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Y-P
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: C-L
authors.initials: CL
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: X-M
authors.initials: XM
authors.lastname: Ou
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Y-L
authors.initials: YL
authors.lastname: Feng
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D005260:Female; D005541:Forced Expiratory Volume; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*; D037701:Pulmonary Surfactant-Associated Protein B / Q000235:genetics*; D012129:Respiratory Function Tests
chemical_list: D037701:Pulmonary Surfactant-Associated Protein B