title: Long-term effects of Roux-en-Y gastric bypass on postprandial plasma lipid and bile acids kinetics in female non diabetic subjects: A cross-sectional pilot study.
abstract: OBJECTIVE
  Formerly obese patients having undergone Roux-en-Y gastric bypass (RYGB) display both an accelerated digestion and absorption of carbohydrate and an increased plasma glucose clearance rate after meal ingestion. How RYGB effects postprandial kinetics of dietary lipids has yet not been investigated.
  
  
  METHODS
  Plasma triglyceride (TG), apoB48, total apoB, bile acids (BA), fibroblast growth factor 19 (FGF19), and cholecystokinin (CCK) were measured in post-absorptive conditions and over 4-h following the ingestion of a mixed test meal in a cross-sectional, pilot study involving 11 formerly obese female patients 33.8 ± 16.4 months after RYGB surgery and in 11 weight- and age-matched female control participants.
  
  
  RESULTS
  Compared to controls, RYGB patients had faster (254 ± 14 vs. 327 ± 7 min, p < 0.05) and lower (0.14 ± 0.04 vs. 0.35 ± 0.07 mM, p < 0.05) peak TG responses, but their peak apoB48 responses tended to be higher (2692 ± 336 vs. 1841 ± 228 ng/ml, p = 0.09). Their postprandial total BA concentrations were significantly increased and peaked earlier after meal ingestion than in controls. Their FGF19 and CCK concentrations also peaked earlier and to a higher value.
  
  
  CONCLUSIONS
  The early postprandial apoB48 and BA responses indicate that RYGB accelerated the rate of dietary lipid absorption. The lower postprandial peak TG strongly suggests that the RYGB simultaneously increased the clearance of TG-rich lipoproteins.
  
  
  BACKGROUND
  NCT01891591.
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
authors.forename: Sara
authors.initials: S
authors.lastname: De Giorgi
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Campos
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
authors.forename: Leonie
authors.initials: L
authors.lastname: Egli
authors.affiliation: Departments of Radiology and Clinical Neurosciences, University Hospital and University of Lausanne, Switzerland.
authors.forename: Ulrike
authors.initials: U
authors.lastname: Toepel
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Carrel
authors.affiliation: INSERM, UMR1087-CNRS UMR6291, l'Institut du Thorax, Faculté de Médecine, Université de Nantes, F-44000 Nantes, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cariou
authors.affiliation: Sorbonne Universités - UPMC Univ Paris 06, INSERM ERL 1157, CNRS UMR 7203 LBM, CHU Saint-Antoine, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Rainteau
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland.
authors.forename: Philippe
authors.initials: P
authors.lastname: Schneiter
authors.affiliation: Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Switzerland. Electronic address: luc.tappy@unil.ch.
authors.forename: Luc
authors.initials: L
authors.lastname: Tappy
authors.affiliation: Center for Metabolic Diseases, Department of Internal Medicine, Broye Intercantonal Hospital, Estavayer-le-lac, Switzerland.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Giusti
mesh_terms: D000328:Adult; D053283:Apolipoprotein B-48 / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D001647:Bile Acids and Salts / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002766:Cholecystokinin / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood; D015390:Gastric Bypass; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D062407:Meals; D009765:Obesity / Q000097:blood / Q000601:surgery; D010865:Pilot Projects; D019518:Postprandial Period; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D053283:Apolipoprotein B-48; D001055:Apolipoproteins B; D001647:Bile Acids and Salts; D001786:Blood Glucose; C117476:FGF19 protein, human; D007328:Insulin; D014280:Triglycerides; D005346:Fibroblast Growth Factors; D052216:Glucagon-Like Peptide 1; D002766:Cholecystokinin
keywords: Apoprotein B48; Bariatric surgery; Bile acids; Fibroblast growth factor 19; Gut hormones; Triglyceride-rich lipoproteins