title: Lack of association betweenLEPRLys656Asn or Ser343Ser polymorphisms and cancer susceptibility: A meta-analysis.
abstract: Previous studies have shown conflicting results between the association of leptin receptor (LEPR) genetic polymorphisms and cancer risk. The frequentLEPRLys656Asn or Ser343Ser genetic polymorphism has been demonstrated to be functional and may promote genetic susceptibility to cancers. However, the association between theLEPRLys656Asn or Ser343Ser genetic polymorphism and cancer risk remains to be determined. To improve the understanding of theLEPRLys656Asn or Ser343Ser genetic polymorphism role in global cancer, a comprehensive meta-analysis was conducted that comprised 2,480 cases and 3,162 controls. TheLEPRLys656Asn or Ser343Ser genetic polymorphism did not significantly affect the cancer risk. In the stratified analysis, there was no significant association of theLEPRLys656Asn or Ser343Ser variants with any type of cancer under any model. In addition, significantly increased risks were found in the Asian population in heterozygous codominant [odds ratio (OR), 1.24 (1.01-1.53)] and dominant [OR, 1.24 (1.02-1.50)] genetic models. A significantly increased susceptibility to cancer was not found when stratified by study design. There were no significant differences found in genotype method and sample size in cases among the genotypes. These findings indicated a lack of association betweenLEPRLys656Asn or Ser343Ser polymorphisms and cancer susceptibility, however, these polymorphisms may increase the cancer susceptibility among the Asian population, particularly in the dominant genetic model. The single-nucleotide polymorphism is also suggested to function as a dominant mutation, which requires verification or association with functional studies.
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China ; Department of First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors.forename: Peng-Cheng
authors.initials: PC
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China.
authors.forename: Yun-Ji
authors.initials: YJ
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China.
authors.forename: Run
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China ; Medical Department, Soochow University, Suzhou, Jiangsu 215123, P.R. China.
authors.forename: Chang-Jia
authors.initials: CJ
authors.lastname: Huang
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China ; Medical Department, Soochow University, Suzhou, Jiangsu 215123, P.R. China.
authors.forename: He-Xi
authors.initials: HX
authors.lastname: Shu
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China ; Medical Department, Soochow University, Suzhou, Jiangsu 215123, P.R. China.
authors.forename: Jin-Peng
authors.initials: JP
authors.lastname: Gong
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China ; Department of First Clinical Medical College, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China.
authors.forename: Quan-Chi
authors.initials: QC
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Cai
keywords: Lys656Asn; Ser343Ser; cancer; genetic polymorphism; leptin receptor; meta-analysis