title: Impact of caspase-8 (CASP8) -652 6N del and D302H polymorphisms on prostate cancer in different ethnic groups.
abstract: BACKGROUND
  Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphisms in prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore, a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302H polymorphisms with PCa susceptibility.
  
  
  METHODS
  A comprehensive literature search was conducted to identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision of the estimate, respectively.
  
  
  RESULTS
  Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6N del and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However, in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in the East Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis strongly suggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominant model.
  
  
  CONCLUSIONS
  In our meta-analysis, ethnic-specific differences were evident in the association of CASP8 -625 6N del and D302H polymorphisms with PCa risk.
authors.affiliation: Medical Scientific Research Center, Guangxi Medical University, Nanning, China E-mail : cncsyxl@126.com.
authors.forename: Cheng-Dong
authors.initials: CD
authors.lastname: Zhang
authors.forename: Hong-Tao
authors.initials: HT
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Liu
authors.forename: Zhi-Di
authors.initials: ZD
authors.lastname: Lin
authors.forename: Qi-Liu
authors.initials: QL
authors.lastname: Peng
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Zeng-Nan
authors.initials: ZN
authors.lastname: Mo
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D053181:Caspase 8 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: C505530:CASP8 protein, human; D053181:Caspase 8