title: A rare debilitating neurological adverse effect of ranolazine due to drug interaction with clarithromycin.
abstract: Medication errors may occur at any point during patient care in the health care system. Drug interaction in known with macrolide antibiotics and ranolazine and is primarily related to effects on the cytochrome P4503A (CYP3A) metabolic pathway. This case highlights medication errors that resulted in rare debilitating neurological adverse effects of ranolazine in an elderly due to drug interaction with clarithromycin.
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Ajay
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Himanshu V
authors.initials: HV
authors.lastname: Pandya
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Nikhil
authors.initials: N
authors.lastname: Dave
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Mahesh
authors.initials: M
authors.lastname: Mathew
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Chinmaye M
authors.initials: CM
authors.lastname: Sapre
authors.affiliation: Department of Medicine, Pramukhswami Medical College, Karamsad, Gujarat, India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Chaudhary
mesh_terms: D000083:Acetanilides / Q000008:administration & dosage / Q000009:adverse effects*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects; D017291:Clarithromycin / Q000008:administration & dosage / Q000009:adverse effects*; D065692:Cytochrome P-450 CYP3A Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D008508:Medication Errors; D020258:Neurotoxicity Syndromes / Q000209:etiology* / Q000503:physiopathology; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects*; D000069458:Ranolazine
chemical_list: D000083:Acetanilides; D000900:Anti-Bacterial Agents; D065692:Cytochrome P-450 CYP3A Inhibitors; D004791:Enzyme Inhibitors; D010879:Piperazines; D000069458:Ranolazine; D017291:Clarithromycin
keywords: Drug interaction; medication error; neurological adverse effects; ranolazine