title: Severe weight loss in 3 months after allogeneic hematopoietic SCT was associated with an increased risk of subsequent non-relapse mortality.
abstract: Patients after allogeneic hematopoietic SCT (HSCT) are at risk of malnutrition. To assess the impact of malnutrition after allogeneic HSCT on transplant outcomes, we conducted a retrospective study. Adult patients who received allogeneic HSCT from 2000 to 2009 for standard-risk leukemia and achieved disease-free survival up to 3 months after allogeneic HSCT were included. From participating centers, 145 patients were enrolled. Median age was 46 years (19-68). Patients were classified based on weight loss during 3 months after allogeneic HSCT as follows: normal group (weight loss <5%, n=53), mild malnutrition group (5%⩽weight loss<10%, n=47), severe malnutrition group (10% ⩽weight loss, n=45). The cumulative incidences of 2-year nonrelapse mortality (NRM) were 3.8% in the normal group, 8.5% in the mild malnutrition group and 27.3% in the severe malnutrition group. The probabilities of a 2-year OS were 73.2% in the normal group, 74.5% in the mild malnutrition group and 55.3% in the severe malnutrition group. In multivariate analysis, severe malnutrition was associated with an increased risk of NRM and a worse OS. In conclusion, weight loss ⩾10% was associated with a worse clinical outcome. Prospective studies that identify patients at risk of malnutrition and intervention by a nutritional support team are warranted.
authors.affiliation: Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fuji
authors.affiliation: Division of Hematology, Keio University Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.affiliation: Department of Medical Oncology, Tata Memorial Center, Mumbai, India.
authors.forename: N
authors.initials: N
authors.lastname: Khattry
authors.affiliation: Department of Nutrion Services, St Vincent's Hospital Sydney, Sydney, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Division of Hemato-oncology, Dongsan Medical Center, Keimyung University, Daegu, Korea.
authors.forename: Y R
authors.initials: YR
authors.lastname: Do
authors.affiliation: Department of Hematology and Clinical Immunology, Kobe University, Kobe, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yakushijin
authors.affiliation: Division of Hematology, Keio University Hospital, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kohashi
authors.affiliation: Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukuda
authors.affiliation: Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.
authors.forename: S-W
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D064591:Allografts; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000401:mortality / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000209:etiology / Q000401:mortality; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D015431:Weight Loss