title: Angiographic correlation and synergistic effect of coronary artery stenosis and cerebral artery stenosis: a retrospective study.
abstract: BACKGROUND
  Comorbidity of coronary artery stenosis (CoAS) and cerebral artery stenosis (CeAS) is relatively common, but little is known about their angiographic correlation and synergistic effect.
  
  
  METHODS
  A total of 66 patients with CoAS were divided into 2 groups: 30 patients with mild CoAS in group A and 36 patients with severe CoAS in group B. Patients were subdivided further into 4 groups: 20 patients with multiple CeAS in group B1, 16 patients with non-multiple CeAS in group B2, 22 patients with multiple CeAS in group A1, and 8 patients with non-multiple CeAS in group A2. Then, the morbidity rates for myocardial infarction and ischemic stroke before angiography were analyzed.
  
  
  RESULTS
  Overall, the incidence and extent of CoAS were positively related to those of CeAS (p=0.004 and p=0.008, respectively). After stratification, the incidences of stenotic vessels in the intracranial arteries (EA) and carotid artery system (CAS) in group B were significantly higher than those in group A (p=0.011 and p=0.007, respectively). Additionally, the morbidity rates for ischemic stroke in groups B1 and A1 showed a weak trend toward a significant difference (p=0.060).
  
  
  CONCLUSIONS
  This study indicates, for the first time, that severe CoAS might be a predictive marker for stenotic vessels of the EA and CAS and for severe CeAS. Furthermore, this study is the first to report that the synergistic effect of CoAS and CeAS might increase the risk of ischemic stroke, which must be confirmed in a large-scale prospective study.
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Hua
authors.initials: H
authors.lastname: Tao
authors.affiliation: Clinical Research Center, Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Clinical Research Center, Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Xu
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Wangtao
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Haihong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Guangdong Key Laboratory of Age-Related Cardiocerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Neurology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China (mainland).
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000175:diagnosis*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies