title: A CREB1-TGFβ2 self-sustaining loop in glioblastoma.
abstract: A subset of glioblastomas (GBM) has high levels of TGFβ signaling, and anti-TGFβ therapies are being pursued as treatments for GBM. The work presented here identifies CREB1 as a potential biomarker for TGFβ-dependent GBM. CREB1 integrates signaling from TGFβ and the PI3K pathway and nucleates a self-sustaining signaling loop that maintains TGFβ2 expression in GBM with high CREB1 levels.
authors.affiliation: Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia. Center for Cell Signaling, University of Virginia, Charlottesville, Virginia. dw2p@virginia.edu.
authors.forename: David
authors.initials: D
authors.lastname: Wotton
mesh_terms: D000818:Animals; D019898:Autocrine Communication; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D053781:Transforming Growth Factor beta2 / Q000378:metabolism*
chemical_list: C115163:CREB1 protein, human; D017362:Cyclic AMP Response Element-Binding Protein; D053781:Transforming Growth Factor beta2