title: Morbidity and mortality in octogenarians with lung cancer undergoing pneumonectomy.
abstract: OBJECTIVE
  Evaluate the restrictiveness of selection criteria for lung resection in lung cancer patients over 80 years of age compared to those applied in younger patients. Compare and analyze 30-day mortality and postoperative complications in both groups of patients.
  
  
  METHODS
  Case-controlled retrospective analysis.
  
  
  METHODS
  Consecutive patients undergoing elective anatomical lung resection. Population was divided into octogenarians (cases) and younger patients (controls). Variables determining surgical risk (BMI, FEV1%, postoperative FEV1%, FEV1/FVC, DLCO and pneumonectomy rate) were compared using either Wilcoxon or Chi-squared tests. Thirty-day mortality and morbidity odds ratio were calculated. A logistic regression model with bootstrap resampling was constructed, including postoperative complications as dependent variable and age and post-operative FEV1% as independent variables. Data were retrieved from a prospective database.
  
  
  RESULTS
  No statistically significant differences were found in BMI (P=.40), FEV1% (P=.41), postoperative FEV1% (P=.23), FEV1/FVC (P=.23), DLCO (P=.76) and pneumonectomy rate (P=.90). Case mortality was 1.85% and control mortality was 1.26% (OR: 1.48). Cardiorespiratory complications occurred in 12.80% of younger subjects and in 13.21% of patients aged 80 years or older. (OR: 1.03). In the logistic regression, only FEV1% was related to postoperative complications (P<.005).
  
  
  CONCLUSIONS
  Selection criteria for octogenarians are similar to those applied in the rest of the population. Advanced age is not a factor for increased 30-day mortality or postoperative morbidity.
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: María
authors.initials: M
authors.lastname: Rodríguez
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Gómez Hernández
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Nuria M
authors.initials: NM
authors.lastname: Novoa
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aranda
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Jiménez
authors.affiliation: Servicio de Cirugía Torácica, Hospital Universitario de Salamanca, Salamanca, España. Electronic address: gvs.@usal.es.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Varela
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008017:Life Expectancy; D008175:Lung Neoplasms / Q000401:mortality* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011013:Pneumonectomy / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D011653:Pulmonary Diffusing Capacity; D012120:Respiration Disorders / Q000453:epidemiology / Q000503:physiopathology; D012189:Retrospective Studies
keywords: Ancianos; Elderly; Neoplasias pulmonares; Neumonectomía; Pneumonectomy; Pulmonary neoplasms; Riesgo quirúrgico; Surgical risk