title: Feasibility of tomotherapy for postoperative irradiation of lower extremity sarcomas.
abstract: OBJECTIVE
  To evaluate the effectiveness of helical tomotherapy-based image-guided radiotherapy (IGRT) following surgery for lower extremity sarcoma.
  
  
  METHODS
  A retrospective review of three patients undergoing postoperative irradiation with tomotherapy for lower extremity sarcoma was conducted. Planning target volume (PTV) coverage, acute side effects, long-term complications and functional results were assessed.
  
  
  RESULTS
  Tomotherapy allows adequate coverage of the PTV without an excessive radiation dose to the normal adjacent structures. Radiotherapy side effects were acceptable with no treatment breaks. All patients were disease free with no complications and no impairment of their daily activity at the last follow-up.
  
  
  CONCLUSIONS
  IGRT delivered by tomotherapy may be ideally suited for sarcoma of the extremities because of its ability to achieve a high radiation dose along with excellent normal tissue sparing. Further prospective studies should be conducted to confirm this hypothesis.
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Vock
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
authors.forename: Rihan
authors.initials: R
authors.lastname: Khan
authors.forename: Benjamin
authors.initials: B
authors.lastname: Slane
authors.forename: Thomas
authors.initials: T
authors.lastname: Sroka
authors.forename: Siyoung
authors.initials: S
authors.lastname: Jang
authors.forename: Vigil
authors.initials: V
authors.lastname: Dias
authors.forename: Richard A
authors.initials: RA
authors.lastname: Vo
authors.forename: Ulf
authors.initials: U
authors.lastname: Karlsson
authors.forename: Alexander
authors.initials: A
authors.lastname: Chi
mesh_terms: D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D035002:Lower Extremity; D008297:Male; D049268:Positron-Emission Tomography; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D061089:Radiotherapy, Image-Guided; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D012509:Sarcoma / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome