title: Correlation between Sun Protection Factor and Antioxidant Activity, Phenol and Flavonoid Contents of some Medicinal Plants.
abstract: Long exposure of UV radiation increases risk of skin diseases such as cancer and photoallergic reactions. UV-B (280-320 nm) radiation is mainly responsible for inducing the skin problems. Skin protection is a suitable method against ultraviolet radiation-induced damage. Various synthetic agents have been used as photo protective but because of their potential toxicity in humans, they have limited usage. Natural substances have been recently considered as potential sunscreen resources due to their absorption in the UV region and their antioxidant activity. In the present study, the UV protective effects of 20 extracts from four common medicinal plants were evaluated. Their phenol and flavonoid contents and antioxidant activities were determined and correlation between SPF and these contents were evaluated. SPFs were between 0.102 and 24.470. The highest value was reached with ultrasonic extract of Crataegus pentagyna (SPF = 24.47) followed by methanolic extract of Feijoa sellowiana (SPF = 1.30). Good correlation was found between SPF and phenolic contents (Correlation Coefficient = 0.55 and p = 0.01) but no correlations were found between SPF and flavonoid contents or antioxidant activity. These extracts can be used alone or as additives in other sun screen formulations to enhance their SPF.
authors.affiliation: Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ebrahimzadeh
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Enayatifard
authors.affiliation: Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Khalili
authors.affiliation: Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Ghaffarloo
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Saeedi
authors.affiliation: Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Yazdani Charati
keywords: Corn silk; Crataegus pentagyna; Feijoa sellowiana; Sambucus ebulus; Sun Protection factor