title: Wnt signaling in kidney tubulointerstitium during disease.
abstract: The evolutionary conserved Wnt signaling transduction pathway plays essential roles in a wide array of biologic processes including embryonic development, branching morphogenesis, proliferation and carcinogenesis. Over the past ten years it has become increasingly clear that Wnt signaling also regulates the response of adult organs to disease processes, including kidney disease. This review will focus on the growing literature implicating important roles for Wnt signaling during disease in two separate kidney compartments: the tubular epithelium and the interstitium.
authors.affiliation: Renal Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Omar H
authors.initials: OH
authors.lastname: Maarouf
authors.affiliation: Renal Division, Brigham and Women's Hospital, and Harvard Medical School, Boston, and Harvard Stem Cell Institute, Cambridge, Massachusetts, USA.
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Ikeda
authors.affiliation: Renal Division, Brigham and Women's Hospital, Boston, MA, USA. bhumphreys@partners.org.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Humphreys
mesh_terms: D000818:Animals; D004848:Epithelium / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000503:physiopathology*; D007674:Kidney Diseases / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D011247:Pregnancy; D015398:Signal Transduction; D051153:Wnt Proteins / Q000235:genetics
chemical_list: D051153:Wnt Proteins