title: Association of schizophrenia with T102C (rs6313) and 1438 A/G (rs6311) polymorphisms of HTR2A gene.
abstract: OBJECTIVE
  The aim of this study is to investigate whether there were any associations between the T102C and 1438 A/G polymorphisms of the 5-HT2A receptor gene and schizophrenia. We conducted a case-control study of the T102C and 1438 A/G polymorphisms in Turkish patients.
  
  
  METHODS
  We compared genotypes and allele frequencies of T102C and 1438 A/G polymorphisms of 5-HT2A receptor gene in 102 patients with schizophrenia diagnosed, according to DSM-IV, and 107 healthy controls. Genotyping was performed by real-time polymerase chain reaction.
  
  
  RESULTS
  We found no significant association between schizophrenia and genotypic or allele frequencies of HTR2A gene 102T/C (rs6313) and 1438 A/G (6311) polymorphisms. However, comparison of HTR2A gene 102 T/C and 1438 A/G polymorphisms in terms of genotypic and allele frequencies between the two patient groups, with or without a family history of schizophrenia, shows that T- and A-allele frequencies were significantly higher (p < 0.05) in the case group that has a history of schizophrenia in their family.
  
  
  CONCLUSIONS
  In conclusion, our results do not support the hypothesis that the T102C and 1438 A/G polymorphisms in the 5-HT2A receptor gene are associated with schizophrenia, but further studies in a larger sample are needed.
authors.affiliation: 1 Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Saliha Handan
authors.initials: SH
authors.lastname: Yildiz
authors.affiliation: 1 Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Asli
authors.initials: A
authors.lastname: Akilli
authors.affiliation: 2 Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Erman
authors.initials: E
authors.lastname: Bagcioglu
authors.affiliation: 1 Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Mujgan
authors.initials: M
authors.lastname: Ozdemir Erdogan
authors.affiliation: 2 Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Kerem Senol
authors.initials: KS
authors.lastname: Coskun
authors.affiliation: 2 Department of Psychiatry, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Ahmet Hamdi
authors.initials: AH
authors.lastname: Alpaslan
authors.affiliation: 3 Elazıg Training and Research Hospital, Elazıg, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Subasi
authors.affiliation: 1 Department of Medical Genetics, Faculty of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Evrim Suna
authors.initials: ES
authors.lastname: Arikan Terzi