title: Genetic polymorphism in DTNBP1 gene is associated with methamphetamine-induced panic disorder.
abstract: OBJECTIVE
  The dysbindin-1 (dystrobrevin-binding protein-1 [DTNBP-1]) gene has repeatedly been shown to be associated with psychotic disorder across diverse populations. In this study, we attempted to investigate the association of the rs3213207 (P1635) genetic polymorphism of the DTNBP1 gene with methamphetamine dependence and with methamphetamine-induced psychosis, manic episodes, and panic disorder in a male Malaysian population.
  
  
  METHODS
  This polymorphism was genotyped in 233 male methamphetamine-dependent subjects and in 301 male controls of the following 4 different ethnicities: Malay, Chinese, Kadazan-Dusun, and Bajau. Intergroup statistical analyses were performed by using the χ(2) test and the Fisher exact test where necessary. In cases of multiple comparisons, the Bonferroni correction was performed.
  
  
  RESULTS
  Our results indicated that the DTNBP1 rs3213207 polymorphism did not show any significant association with risk of methamphetamine dependence, either in the pooled subjects or after stratification into the 4 different ethnic groups (P > 0.05). Furthermore, we did not find any association of this polymorphism with methamphetamine-induced psychosis and episodes of methamphetamine-induced mania. However, there was a strong association between this polymorphism and the occurrence of methamphetamine-induced panic disorder in the pooled subjects (odds ratio [OR] = 6.739, P < 0.001) and in the Malay (OR = 11.93, P = 0.022) and Kadazan-Dusun (OR = 115.0, P < 0.001) groups.
  
  
  CONCLUSIONS
  Our findings suggest that the DTNBP1 rs3213207 polymorphism may contribute to methamphetamine-induced panic disorder in the pooled Malaysian male population, especially in the Malay and Kadazan-Dusun ethnic groups. However, no association was found with methamphetamine dependence, methamphetamine-induced psychosis, or methamphetamine-induced mania.
authors.affiliation: From the Department of Pharmacology (MSS, SHD, and ZM), and Department of Psychological Medicine (AH), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Maw Shin
authors.initials: MS
authors.lastname: Sim
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hatim
authors.forename: Shiau Hui
authors.initials: SH
authors.lastname: Diong
authors.forename: Zahurin
authors.initials: Z
authors.lastname: Mohamed
mesh_terms: D019969:Amphetamine-Related Disorders / Q000235:genetics* / Q000523:psychology; D044466:Asian People / Q000235:genetics / Q000523:psychology; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008296:Malaysia; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D016584:Panic Disorder / Q000139:chemically induced / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: C432416:DTNBP1 protein, human; D000074765:Dysbindin; D049029:Dystrophin-Associated Proteins; D008694:Methamphetamine