title: Differential transcriptional activity of kidney genes in hypertensive ISIAH and normotensive WAG rats.
abstract: Transcriptional activity of the kidney genes was compared in hypertensive ISIAH and normotensive WAG rats using the oligonucleotide microarray technique. Most of differentially expressed genes were downregulated in ISIAH kidney both in renal cortex and medulla. According to functional annotation the kidney function in ISIAH rats is based on altered expression of many genes working in stress-related mode. The alterations in gene expression are likely related to both pathophysiological and compensatory mechanisms. The further studies of genes differentially expressed in ISIAH and WAG kidney will help to reveal new hypertensive genes and mechanisms specific for stress-induced arterial hypertension.
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences , Novosibirsk , Russian Federation.
authors.forename: Olga Evgenievna
authors.initials: OE
authors.lastname: Redina
authors.forename: Svetlana Eduardovna
authors.initials: SE
authors.lastname: Smolenskaya
authors.forename: Tatiana Olegovna
authors.initials: TO
authors.lastname: Abramova
authors.forename: Liudmila Nikolaevna
authors.initials: LN
authors.lastname: Ivanova
authors.forename: Arcady L'vovich
authors.initials: AL
authors.lastname: Markel
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004851:Epoxide Hydrolases / Q000235:genetics*; D020869:Gene Expression Profiling; D055106:Genome-Wide Association Study; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D008297:Male; D019696:Peptidylprolyl Isomerase / Q000235:genetics*; D051381:Rats; D013312:Stress, Physiological / Q000235:genetics*; D015533:Transcriptional Activation
chemical_list: D002394:Catechol O-Methyltransferase; D004851:Epoxide Hydrolases; C529022:EPHX2 protein, rat; D019696:Peptidylprolyl Isomerase
keywords: ISIAH rats; kidney; microarray; stress-induced arterial hypertension; transcriptional activity of genes