title: Lymphocyte migration into atherosclerotic plaque.
abstract: Adaptive immunity is involved in the pathogenesis of atherosclerosis, but the recruitment of T and B lymphocytes to atherosclerotic lesions is not as well studied as that of monocytes. In this review, we summarize the current understanding of the role of lymphocyte subsets in the pathogenesis of atherosclerosis and discuss chemokines and chemokine receptors involved in lymphocyte homing to atherosclerotic lesions. We review evidence for involvement of the chemokines CCL5, CCL19, CCL21, CXCL10, and CXCL16 and macrophage migration inhibitory factor in lymphocyte homing in atherosclerosis. Also, we review the role of their receptors CCR5, CCR6, CCR7, CXCR3, CXCR6, and CXCR2/CXCR4 and the role of the L-selectin in mouse models of atherosclerosis.
authors.affiliation: From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, CA. klaus@liai.org.
authors.forename: Klaus
authors.initials: K
authors.lastname: Ley
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D001808:Blood Vessels / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D018925:Chemokines / Q000378:metabolism; D002634:Chemotaxis, Leukocyte; D004195:Disease Models, Animal; D006801:Humans; D019041:L-Selectin / Q000378:metabolism; D016131:Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008263:Macrophage Migration-Inhibitory Factors / Q000378:metabolism; D051379:Mice; D058226:Plaque, Atherosclerotic; D019707:Receptors, Chemokine / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018925:Chemokines; D008263:Macrophage Migration-Inhibitory Factors; D019707:Receptors, Chemokine; D019041:L-Selectin
keywords: CC chemokine receptor; atherosclerosis; lymphocytes