title: Restless genital syndrome in Parkinson disease.
abstract: OBJECTIVE
  Symptoms in the genital region, such as pain, discomfort, tingling, and burning sensations, have rarely been reported in Parkinson disease (PD), and the previous cases were attributed to nonmotor off symptoms. We report a patient with PD and severe genital discomfort unrelated to motor fluctuations but compatible with restless genital syndrome.
  
  
  METHODS
  A 65-year-old woman with PD experienced a disabling discomfort in her pelvis and genital region for 3 years. The episodes occurred in the evening and were triggered by sitting or lying down for a period. Gynecological investigation was unrevealing. She experienced improvement with a low dose of a dopamine agonist.
  
  
  CONCLUSIONS
  Restless genital syndrome is a rare disorder that can be a source of distress and disability. In patients with PD, restless genital syndrome should be included in the differential diagnosis of genital symptoms and restlessness, along with nonmotor wearing off and akathisia. A detailed clinical history is essential for this diagnosis and treatment with dopamine agonists can provide benefit.
authors.affiliation: Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada2Department of Neurology, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Camila C
authors.initials: CC
authors.lastname: Aquino
authors.affiliation: Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada3Division of Neurology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
authors.forename: Tiago
authors.initials: T
authors.lastname: Mestre
authors.affiliation: Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital, Toronto, Ontario, Canada.
authors.forename: Anthony E
authors.initials: AE
authors.lastname: Lang
mesh_terms: D000368:Aged; D052160:Benzothiazoles / Q000008:administration & dosage / Q000494:pharmacology; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D010300:Parkinson Disease / Q000150:complications*; D000077487:Pramipexole; D013577:Syndrome
chemical_list: D052160:Benzothiazoles; D018491:Dopamine Agonists; D000077487:Pramipexole