title: [Feasibility study of QAMS for quantitative analysis of multiple structural types of ingredients in Zhizi Jinhua pill].
abstract: OBJECTIVE
  To study the technical feasibility of QAMS to determine different structural types of ingredients in Zhizi Jinhua pill, a Chinese patent medicine.
  
  
  METHODS
  Emodin was chosen as the internal reference substance. The relative correction factors (RCF) of berberine, baicalin, wogonoside, baicalein, aloe-emodin, wogonin, rhein, chrysophanol and physcion to emodin were calculated with the peak areas determined at 254 nm. The ruggedness of these RCFs was validated. The contents of emodin in the samples of Zhizi Jinhua pill were determined by using the external standard method, and the contents of the other nine ingredients were calculated by their RCFs. The contents of these ten ingredients in all samples were also determined by the external standard method.
  
  
  RESULTS
  No significant differences were observed between the quantitative results of the two methods. The obtained RCFs were credible.
  
  
  CONCLUSIONS
  The established QAMS method can be used for quantitative determination of different structural types of multi-compounds in Zhizi Jinhua pill. It can provide reference for the quality control of Chinese patent medicine.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Feng
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Zhang
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Gao
authors.forename: Chun
authors.initials: C
authors.lastname: Li
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Liu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yan
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhu
authors.forename: Liang-Mian
authors.initials: LM
authors.lastname: Chen
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004304:Dosage Forms; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D011786:Quality Control
chemical_list: D004304:Dosage Forms; D004365:Drugs, Chinese Herbal