title: Prevalence of human papillomavirus infection in Greek patients with squamous cell carcinoma of the larynx.
abstract: OBJECTIVE
  The causal relation between human papillomavirus (HPV) infection and squamous cell carcinoma (SCC) of the larynx has not been yet clarified. The aim of the present study was to investigate HPV infection in 54 SCC of the larynx and correlate it with patients' epidemiological and clinicopathological data.
  
  
  METHODS
  Fifty-four biopsies were collected from patients with laryngeal SCC and tested for HPV DNA. Local recurrence analysis was performed at the 2- year follow-up.
  
  
  RESULTS
  HPV DNA was detected in 18.5% (10/54) of laryngeal SCC; infection from high risk (hr) HPV and low risk (lr) HPV types was found in 16.7% (9/54) and 1.8% (1/54) of the samples, respectively. HPV 16 was the commonest type detected in 7.5% (4/54). The presence of HPV DNA was significantly associated with the absence of tobacco use (p=0.001) and poorly differentiated tumors (p=0.003).
  
  
  CONCLUSIONS
  This study confirms the prevalence of HPV infection among patients with SCC of the larynx.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Metaxas Cancer Hospital, Piraeus, Greece.
authors.forename: Spyros
authors.initials: S
authors.lastname: Laskaris
authors.affiliation: 1st Department of Otolaryngology, Head and Neck Surgery, "Hippokration" General Hospital of Athens, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Sengas
authors.affiliation: 2nd Department of Otolaryngology, Head and Neck Surgery, "Attikon" General Hospital of Athens, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Pavlos
authors.initials: P
authors.lastname: Maragoudakis
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Elpida
authors.initials: E
authors.lastname: Tsimplaki
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece.
authors.forename: Elena
authors.initials: E
authors.lastname: Argyri
authors.affiliation: 1st Department of Otolaryngology, Head and Neck Surgery, "Hippokration" General Hospital of Athens, School of Medicine, University of Athens, Athens, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Manolopoulos
authors.affiliation: Department of Virology, "St. Savvas" Regional Anticancer Oncology Hospital of Athens, Athens, Greece epanot@tee.gr.
authors.forename: Efstathia
authors.initials: E
authors.lastname: Panotopoulou
mesh_terms: D000328:Adult; D000368:Aged; D052685:Alphapapillomavirus / Q000145:classification / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009364:Neoplasm Recurrence, Local; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D047368:Tumor Burden
keywords: HPV; head and neck squamous cell carcinomas; laryngeal cancer; oropharyngeal cancer