title: A new biomarker quantifies differences in clot microstructure in patients with venous thromboembolism.
abstract: This study compared patients with venous thromboembolism (VTE) to non-VTE patients using a biomarker of clot microstructure (df ) and clot formation time (TGP ). df was the only marker that identified a significant difference (P < 0·001) between the VTE (n = 60) and non-VTE cohorts (n = 69). The 'abnormal' clot microstructures in the VTE patients suggests either inadequate response to anticoagulant therapy or the presence of a procoagulant state not detected by other markers of coagulation (i.e., International Normalized Ratio). Furthermore, elevated values of df in first time VTE patients who later develop a secondary event indicates that df may identify those at risk of recurrence.
authors.affiliation: NISCHR Haemostasis Biomedical Research Unit, Morriston Hospital, Abertawe Bro Morgannwg University Health Board, Swansea, UK; College of Medicine, Swansea University, Swansea, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Lawrence
authors.forename: Ahmed
authors.initials: A
authors.lastname: Sabra
authors.forename: Gavin
authors.initials: G
authors.lastname: Mills
authors.forename: Suresh G
authors.initials: SG
authors.lastname: Pillai
authors.forename: Wendy
authors.initials: W
authors.lastname: Abdullah
authors.forename: Karl
authors.initials: K
authors.lastname: Hawkins
authors.forename: Roger H K
authors.initials: RH
authors.lastname: Morris
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Davidson
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: D'Silva
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Curtis
authors.forename: Martin R
authors.initials: MR
authors.lastname: Brown
authors.forename: John W
authors.initials: JW
authors.lastname: Weisel
authors.forename: Phylip R
authors.initials: PR
authors.lastname: Williams
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Evans
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests; D054459:Elasticity Imaging Techniques; D005260:Female; D005337:Fibrin / Q000032:analysis; D005342:Fibrinolysis; D005782:Gels; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D054556:Venous Thromboembolism / Q000097:blood* / Q000188:drug therapy; D055682:Viscoelastic Substances; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D005782:Gels; D055682:Viscoelastic Substances; D014859:Warfarin; D005337:Fibrin
keywords: anticoagulation; blood coagulation; haemostasis; venous thrombosis; warfarin