title: Case report: adrenal oncocytoma associated with markedly increased FDG uptake and immunohistochemically positive for GLUT1.
abstract: Usually, benign tumors are not associated with an increased F-18 fluorodeoxyglucose (F-18 FDG) uptake on positron emission tomography (PET), although some exceptions have been reported in adrenal neoplasms. We present a rare case of adrenocortical oncocytoma associated with markedly increased FDG uptake, demonstrating a maximum standardized uptake value of 46.8. Histological examination demonstrated diffuse proliferation of tumor cells with eosinophilic and granular cytoplasm that were diffusely immunopositive for mitochondria and glucose transport protein 1, with focal and weak immunopositivity for 3β-hydroxysteroid dehydrogenase. Ultrastructural examination also revealed abundant mitochondria in the tumor cells. The tumor was diagnosed as adrenocortical oncocytoma and was considered benign according to Lin-Weiss-Bisceglia criteria. Diagnosis of adrenocortical oncocytoma can pose difficulties during both preoperative radiological and postoperative histopathological investigations.
authors.affiliation: Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Sato
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kentaro
authors.initials: K
authors.lastname: Takanami
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Ono
authors.forename: Kei
authors.initials: K
authors.lastname: Omata
authors.forename: Ryo
authors.initials: R
authors.lastname: Morimoto
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Satoh
authors.forename: Kazue
authors.initials: K
authors.lastname: Ise
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yamada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kasajima
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Fujishima
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Arai
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sasano
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*
chemical_list: D051272:Glucose Transporter Type 1; D019275:Radiopharmaceuticals; C495677:SLC2A1 protein, human; D019788:Fluorodeoxyglucose F18