title: Lesion with morphologic feature of organizing pneumonia (OP) in CT-guided lung biopsy samples for diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP): a retrospective study of 134 cases in a single center.
abstract: BACKGROUND
  Small biopsy samples are generally considered inconclusive for bronchiolitis obliterans organizing pneumonia (BOOP) diagnosis despite their potential to reveal organizing pneumonia (OP) pathologically, necessitating risky invasive tissue biopsy during surgery for reliable confirmation.
  
  
  OBJECTIVE
  OP by CT-guided lung biopsy was to evaluate the role in the diagnosis of BOOP.
  
  
  METHODS
  A retrospective review of 134 cases with the OP feature in the CT-guided lung biopsy samples between 2004 and 2011 at a single center was conducted. Diagnostic accuracy of OP by CT-guided lung biopsy and clinical-radiographic data alone were compared.
  
  
  RESULTS
  After exclusion of 11 cases due to pathology with others besides OP and 15 cases for loss to follow-up, 108 were included. Of these, 95 cases and 13 cases were classified as BOOP and non-BOOP group, respectively. Among BOOP group, only 30 were initially diagnosed as BOOP according to the typical clinical and radiographic features. The other 65 cases with atypical features were diagnosed as BOOP mainly based on OP by CT-guided lung biopsy. Among non-BOOP group, one was misdiagnosed as BOOP, and others were not BOOP according to clinical and radiographic findings. Thus, OP by CT-guided lung biopsy produced a diagnostic accuracy of 87.96% (95/108), much higher than 31.25% (30/96) observed using clinical and radiographic data alone. Combined, these techniques produced diagnostic accuracy of 98.96% (95/96).
  
  
  CONCLUSIONS
  OP by CT-guided lung biopsy can be effectively used as the pathological evidence for BOOP diagnosis and reducing unnecessary surgery.
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Miao
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Ding
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Chen
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Jinghong
authors.initials: J
authors.lastname: Dai
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Hourong
authors.initials: H
authors.lastname: Cai
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Yonglong
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Min
authors.initials: M
authors.lastname: Cao
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Huang
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Yuying
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Fanqing
authors.initials: F
authors.lastname: Meng
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Xiangshan
authors.initials: X
authors.lastname: Fan
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Deping
authors.initials: D
authors.lastname: Zhang
authors.affiliation: 1 Department of Respiratory Medicine, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China ; 2 Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China ; 3 Department of Pathology, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing 210008, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
keywords: Bronchiolitis obliterans organizing pneumonia (BOOP); CT-guided lung biopsy; diagnosis; organizing pneumonia (OP); retrospective study