title: Evidence that bisphenol A (BPA) can be accurately measured without contamination in human serum and urine, and that BPA causes numerous hazards from multiple routes of exposure.
abstract: There is extensive evidence that bisphenol A (BPA) is related to a wide range of adverse health effects based on both human and experimental animal studies. However, a number of regulatory agencies have ignored all hazard findings. Reports of high levels of unconjugated (bioactive) serum BPA in dozens of human biomonitoring studies have also been rejected based on the prediction that the findings are due to assay contamination and that virtually all ingested BPA is rapidly converted to inactive metabolites. NIH and industry-sponsored round robin studies have demonstrated that serum BPA can be accurately assayed without contamination, while the FDA lab has acknowledged uncontrolled assay contamination. In reviewing the published BPA biomonitoring data, we find that assay contamination is, in fact, well controlled in most labs, and cannot be used as the basis for discounting evidence that significant and virtually continuous exposure to BPA must be occurring from multiple sources.
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO 65211 USA. Electronic address: vomsaalf@missouri.edu.
authors.forename: Frederick S
authors.initials: FS
authors.lastname: vom Saal
authors.affiliation: Department of Biomedical Sciences, University of Missouri, Columbia MO 65211 USA.
authors.forename: Wade V
authors.initials: WV
authors.lastname: Welshons
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000097:blood / Q000633:toxicity / Q000652:urine; D052244:Endocrine Disruptors / Q000097:blood / Q000633:toxicity / Q000652:urine; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D010636:Phenols / Q000097:blood / Q000633:toxicity / Q000652:urine; D018570:Risk Assessment; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Biomonitoring; Bisphenol A; Contamination; Endocrine disrupting chemicals; Pharmacokinetics