title: Association of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms with the risk of COPD: an updated meta-analysis of 2,644 cases and 4,804 controls.
abstract: A series of observational studies have been made to investigate the association of the ADAM33 gene polymorphisms with the risk of COPD, but their results were conflicting. Therefore, we performed an updated meta-analysis to quantitatively summarize the associations of ADAM33 gene polymorphisms with the risk of COPD. Thirteen case-control studies referring to nine SNPs were identified: V4 (rs2787094), T+1 (rs2280089), T2 (rs2280090), T1 (rs2280091), S2 (rs528557), S1 (rs3918396), Q-1 (rs612709), F+1 (rs511898) and ST+5 (rs597980). A dominant model (AA+Aa vs. aa), recessive model (AA vs. Aa+aa), additive model (AA vs. aa) and allelic model (A vs. a) were used to evaluate the association of ADAM33 polymorphism with the risk of COPD. The results indicated that significant associations were found for ADAM33 T1, T2, S1, Q-1, F+1 and ST+5 polymorphisms associated with the risk of COPD in different populations. However, no significant associations were found for V4, T+1 and S2 polymorphisms with the risk of COPD in all genetic models, even in the subgroup analysis by ethnicity. This meta-analysis provided evidence that the ADAM33 T1, T2, S1, Q-1, F+1 and ST+5 six locus polymorphisms association with the risk of COPD. Furthermore, T2, Q-1 and ST+5 indicated an association with the risk of COPD in the European populations, whereas T1, T2, S1, F+1 and Q-1 indicated an association with the risk of COPD in the Asian populations.
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital, Anhui Medical University, Hefei, 230022, Anhui, China.
authors.forename: Deng-Chuan
authors.initials: DC
authors.lastname: Zhou
authors.forename: Cheng-Fan
authors.initials: CF
authors.lastname: Zhou
authors.forename: Sam
authors.initials: S
authors.lastname: Toloo
authors.forename: Tong
authors.initials: T
authors.lastname: Shen
authors.forename: Shi-Lu
authors.initials: SL
authors.lastname: Tong
authors.forename: Qi-Xing
authors.initials: QX
authors.lastname: Zhu
mesh_terms: D051722:ADAM Proteins / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D029424:Pulmonary Disease, Chronic Obstructive / Q000453:epidemiology* / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics
chemical_list: D051722:ADAM Proteins; C450441:ADAM33 protein, human