title: Role of surgical treatment in breast cancer liver metastases: a single center experience.
abstract: OBJECTIVE
  The aim of the present study was to review a single hepatobiliary center experience, the benefit of hepatic metastasectomy in breast cancer liver metastases (BCLM) patients and to identify predictors of survival.
  
  
  METHODS
  Fifty-two female patients underwent surgery for BCLM between 2002 and 2013. Only patients with liver resections (n=43) were included in the analysis.
  
  
  RESULTS
  The median survival of the 43 patients with liver resection was 32.2 months. The factors significantly associated with overall post-hepatectomy survival were estrogen/progesteron receptor (ER/PR) status (p=0.002), node involvement of the primary tumor (p=0.049), size (p=0.005) and number (p=0.006) of the metastatic lesions. The 1-, 3- and 5-year survival rates after curative liver resection were 93.02%, 74.42%, 58.14%, respectively.
  
  
  CONCLUSIONS
  BCLM resection is a safe procedure and offers survival benefit, especially in patients with reduced liver metastatic burden (solitary metastases, diameter of the metastases <5 cm) and positive ER/PR status.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
authors.forename: Nicolae
authors.initials: N
authors.lastname: Bacalbasa
authors.affiliation: Center of Digestive Diseases and Liver Transplantation, Center of General Surgery and Liver Transplantation "Dan Setlacec", Fundeni Clinical Institute, Bucharest, Romania.
authors.forename: Simona Olimpia
authors.initials: SO
authors.lastname: Dima
authors.affiliation: Department of Mathematical Methods & Models, University Politehnica Bucharest, Faculty of Applied Sciences, Bucharest, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Purtan-Purnichescu
authors.affiliation: Department of Pathology, Fundeni Clinical Institute, Department of Pathology, Bucharest, Romania.
authors.forename: Vlad
authors.initials: V
authors.lastname: Herlea
authors.affiliation: Center of Digestive Diseases and Liver Transplantation, Center of General Surgery and Liver Transplantation "Dan Setlacec", Fundeni Clinical Institute, Bucharest, Romania irinel.popescu220@gmail.com.
authors.forename: Irinel
authors.initials: I
authors.lastname: Popescu
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Breast cancer liver metastases; estrogen/progesteron receptor status; liver resection