title: Piezo proteins: regulators of mechanosensation and other cellular processes.
abstract: Piezo proteins have recently been identified as ion channels mediating mechanosensory transduction in mammalian cells. Characterization of these channels has yielded important insights into mechanisms of somatosensation, as well as other mechano-associated biologic processes such as sensing of shear stress, particularly in the vasculature, and regulation of urine flow and bladder distention. Other roles for Piezo proteins have emerged, some unexpected, including participation in cellular development, volume regulation, cellular migration, proliferation, and elongation. Mutations in human Piezo proteins have been associated with a variety of disorders including hereditary xerocytosis and several syndromes with muscular contracture as a prominent feature.
authors.affiliation: Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520.
authors.forename: Sviatoslav N
authors.initials: SN
authors.lastname: Bagriantsev
authors.affiliation: Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520; Yale Program in Cellular Neuroscience, Neurodegeneration and Repair, and Yale University School of Medicine, New Haven, Connecticut 06520.
authors.forename: Elena O
authors.initials: EO
authors.lastname: Gracheva
authors.affiliation: Departments of Pediatrics, Pathology, and Genetics, Yale University School of Medicine, New Haven, Connecticut 06520. Electronic address: patrick.gallagher@yale.edu.
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Gallagher
mesh_terms: D000595:Amino Acid Sequence; D000745:Anemia, Hemolytic, Congenital / Q000235:genetics; D000818:Animals; D055724:Electrophysiological Phenomena; D004912:Erythrocytes / Q000166:cytology; D006801:Humans; D015160:Hydrops Fetalis / Q000235:genetics; D007473:Ion Channels / Q000737:chemistry / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D009475:Neurons, Afferent / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
chemical_list: D007473:Ion Channels; C515204:PIEZO1 protein, human; C000589132:PIEZO2 protein, human; C552920:Piezo1 protein, mouse; C552921:Piezo2 protein, mouse
keywords: Arthrogryposis; Genetic Disease; Gordon Syndrome; Hereditary Xerocytosis; Ion Channel; Mechanotransduction; Membrane Protein; Neuron; Piezo1; Piezo2; Somatosensation