title: Platelet rich plasma and knee surgery.
abstract: In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the field of regenerative medicine is witnessing a boost of autologous blood-derived platelet rich plasma products (PRPs) application to effectively mimic and accelerate the tissue healing process. The scientific rationale behind PRPs is the delivery of growth factors, cytokines, and adhesive proteins present in platelets and plasma, as well as other biologically active proteins conveyed by the plasma such as fibrinogen, prothrombin, and fibronectin; with this biological engineering approach, new perspectives in knee surgery were opened. This work describes the use of PRP to construct and repair every single anatomical structure involved in knee surgery, detailing the process conducted in ligament, meniscal, and chondral surgery.
authors.affiliation: Arthroscopic Surgery Unit, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain ; Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.
authors.forename: Mikel
authors.initials: M
authors.lastname: Sánchez
authors.affiliation: Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.
authors.forename: Diego
authors.identifier: 0000-0002-0494-0804
authors.initials: D
authors.lastname: Delgado
authors.affiliation: Arthroscopic Surgery Unit Research, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.
authors.forename: Pello
authors.initials: P
authors.lastname: Sánchez
authors.affiliation: Arthroscopic Surgery Unit, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.
authors.forename: Nicolás
authors.identifier: 0000-0002-6061-8967
authors.initials: N
authors.lastname: Fiz
authors.affiliation: Arthroscopic Surgery Unit, Hospital Vithas San Jose, C/Beato Tomás de Zumarraga 10, 01008 Vitoria-Gasteiz, Spain.
authors.forename: Juan
authors.identifier: 0000-0002-6864-9258
authors.initials: J
authors.lastname: Azofra
authors.affiliation: Fundación Eduardo Anitua, C/Jose María Cagigal 19, 01007 Vitoria-Gasteiz, Spain.
authors.forename: Gorka
authors.initials: G
authors.lastname: Orive
authors.affiliation: Fundación Eduardo Anitua, C/Jose María Cagigal 19, 01007 Vitoria-Gasteiz, Spain.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Anitua
authors.affiliation: Fundación Eduardo Anitua, C/Jose María Cagigal 19, 01007 Vitoria-Gasteiz, Spain.
authors.forename: Sabino
authors.initials: S
authors.lastname: Padilla
mesh_terms: D001178:Arthroplasty / Q000379:methods*; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology* / Q000601:surgery*; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma / Q000502:physiology*; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*