title: Cognitive control network function in alcohol use disorder before and during treatment with lorazepam.
abstract: Individuals with alcohol use disorders (AUDs) have deficits in cognitive control, but how they change with treatment is unclear. Seven patients with AUD and anxiety from an open-label trial of disulfiram plus lorazepam performed a multisensory Stroop task during fMRI (both pre and post initiation of treatment), and were compared to nine healthy controls (HCs) (n = 16; Albuquerque, NM; years 2009-2012). Evoked BOLD signal and resting state functional connectivity were compared (HC vs. AUD; Scan 1 vs. Scan 2). AUD demonstrated hyperactivity and altered connectivity in the cognitive control network compared to HC, but treatment did not normalize function.
authors.affiliation: 1Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
authors.forename: Claire E
authors.initials: CE
authors.lastname: Wilcox
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Mayer
authors.forename: Michael P
authors.initials: MP
authors.lastname: Bogenschutz
authors.forename: Josef
authors.initials: J
authors.lastname: Ling
authors.forename: Charlene
authors.initials: C
authors.lastname: Dekonenko
authors.forename: Heather
authors.initials: H
authors.lastname: Cumbo
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000188:drug therapy* / Q000523:psychology; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D016022:Case-Control Studies; D003071:Cognition / Q000187:drug effects*; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000187:drug effects; D057190:Stroop Test
chemical_list: D014151:Anti-Anxiety Agents; D008140:Lorazepam
keywords: Stroop; alcohol dependence; alcohol use disorder; benzodiazepine; cognitive control; connectivity; fMRI; lorazepam; treatment