title: The effect of an interdisciplinary rehabilitation intervention comparing HRQoL, symptom burden and physical function among patients with primary glioma: an RCT study protocol.
abstract: BACKGROUND
  Gliomas are among the biggest challenges in neurological and oncology rehabilitation and optimising treatment is of major clinical importance in this population. Although inpatient rehabilitation among glioma patients' results in improved functional measures, rehabilitation efforts are still not emphasised in this patient group and the literature lacks studies investigating the impact of outpatient rehabilitation.
  
  
  METHODS
  This protocol describes a randomised 6-week parallel group rehabilitation study investigating an outpatient interdisciplinary rehabilitation programme. The intervention consists of 6 weeks intensive physiotherapy as groups exercise in conjunction with 0-6 weeks of individual occupational therapy if a need is present. The aim of this study is to describe the design of the upcoming randomised control trial (RCT). The results of the RCT will add to the growing body of literature investigating the potential role of exercise as a supportive therapeutic intervention for a patient with cancer.
  
  
  BACKGROUND
  The project is approved by the Regional Scientific Ethical Committees for Southern Denmark under Project-ID: (S-20140108) and by the Danish Data Protection Agency (J. no.2008-58-0035). Dissemination will occur through presentation and findings will be published in peer-reviewed journals. The key strength of this study is its randomised design and it is the first study to investigate a standardised outpatient interdisciplinary rehabilitation programme among patients with glioma. A potential limitation is the uncertainty and risk of side effects to the concomitant treatment, which enhances the risk of dropout.
  
  
  BACKGROUND
  ClinicalTrials.gov Identifier NCT02221986.
authors.affiliation: Rehabilitation Unit, Odense University Hospital, Odense, Fyn, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Hansen
authors.affiliation: Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
authors.forename: Lisbeth Kirstine
authors.initials: LK
authors.lastname: Rosenbek Minet
authors.affiliation: Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
authors.forename: Karen
authors.initials: K
authors.lastname: Søgaard
authors.affiliation: Department of Neurology, Herlev University Hospital, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Jens Ole
authors.initials: JO
authors.lastname: Jarden
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000534:rehabilitation*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D005910:Glioma / Q000534:rehabilitation*; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D009788:Occupational Therapy / Q000379:methods*; D010348:Patient Care Team; D026741:Physical Therapy Modalities; D011788:Quality of Life; D055070:Resistance Training; D016896:Treatment Outcome; D055815:Young Adult
keywords: REHABILITATION MEDICINE