title: Which factors influence radiographic progression during treatment with tumor necrosis factor inhibitors in clinical practice? Results from 930 patients with rheumatoid arthritis in the nationwide Danish DANBIO registry.
abstract: OBJECTIVE
  To investigate baseline characteristics associated with radiographic progression and the effect of disease activity, drug, switching, and withdrawal on radiographic progression in tumor necrosis factor (TNF) inhibitor-naive patients with rheumatoid arthritis (RA) followed for about 2 years after anti-TNF initiation in clinical practice.
  
  
  METHODS
  DANBIO-registered patients with RA who had available radiographs (anti-TNF initiation and ∼2 yrs followup) were included. Radiographs were scored, blinded to chronology with the Sharp/van der Heijde method and linked with DANBIO data. Baseline characteristics were investigated with univariate regression and significant variables included in a multivariable logistic regression analysis with ± radiographic progression [Δ total Sharp score (TSS) > 0] as dependent variable. Effect of time-averaged C-reactive protein (CRP), 28-joint Disease Activity Score with CRP (DAS28-CRP), and treatment status at followup were investigated with univariate regression analysis.
  
  
  RESULTS
  The study included 930 patients. They were 75% women, 79% positive for IgM-rheumatoid factor (IgM-RF), median age was 57 yrs (range 19-88), disease duration 9 yrs (1-59), DAS28-CRP 5.0 (1.4-7.8), TSS median 15 [3-45 interquartile range (IQR)] and mean 31 (SD 40). Patients started treatment with infliximab (59%), etanercept (18%), or adalimumab (23%). At followup (median 526 days, IQR 392-735), 61% were treated with the initial anti-TNF, 29% had switched TNF inhibitor, and 10% had withdrawn. Twenty-seven percent of patients had progressed radiographically. ΔTSS was median 0.0 [0.0-0.5 IQR/mean 0.6 (SD 2.4)] units/year. Higher TSS, older age, positive IgM-RF, and concomitant prednisolone at baseline were associated with radiographic progression. Time-averaged DAS28-CRP and time-averaged CRP, but not type of TNF inhibitor, were associated with radiographic progression. Patients who stopped/switched during followup progressed more than patients who continued treatment.
  
  
  CONCLUSIONS
  High TSS, older age, IgM-RF positivity, and concomitant prednisolone were associated with radiographic progression during 2 years of followup of 930 anti-TNF-treated patients with RA in clinical practice. High disease activity and switching/stopping anti-TNF treatment were associated with radiographic progression.
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Lykke Midtbøll
authors.initials: LM
authors.lastname: Ørnbjerg
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Mikkel
authors.initials: M
authors.lastname: Østergaard
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Pernille
authors.initials: P
authors.lastname: Bøyesen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Niels Steen
authors.initials: NS
authors.lastname: Krogh
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Anja
authors.initials: A
authors.lastname: Thormann
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Ulrik
authors.initials: U
authors.lastname: Tarp
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Uta Engling
authors.initials: UE
authors.lastname: Poulsen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Jakob
authors.initials: J
authors.lastname: Espesen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Annette
authors.initials: A
authors.lastname: Schlemmer
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Niels
authors.initials: N
authors.lastname: Graudal
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Gina
authors.initials: G
authors.lastname: Kollerup
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Dorte Vendelbo
authors.initials: DV
authors.lastname: Jensen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Ole Rintek
authors.initials: OR
authors.lastname: Madsen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Bente
authors.initials: B
authors.lastname: Glintborg
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Torben
authors.initials: T
authors.lastname: Christensen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Hanne
authors.initials: H
authors.lastname: Lindegaard
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bøhme
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Annette
authors.initials: A
authors.lastname: Hansen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Anne Rødgaard
authors.initials: AR
authors.lastname: Andersen
authors.affiliation: From the DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, Glostrup; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Zitelab Aps, Copenhagen; Department of Rheumatology, Aarhus University Hospital, Aarhus; Rheumatism Hospital, University of Southern Denmark, Gråsten; Department of Internal Medicine, Lillebælt Hospital, Vejle; Department of Rheumatology, Aarhus University Hospital, Aalborg; Department of Rheumatology, Copenhagen University Hospital Rigshospitalet; Department of Rheumatology, Copenhagen University Hospital Frederiksberg, Copenhagen; Department of Rheumatology, Helsingør Hospital, Helsingør; Department of Rheumatology/C, Copenhagen University Hospital Gentofte, Hellerup; Department of Internal Medicine, Holbæk Hospital, Holbæk; Department of Rheumatology, Copenhagen University Hospital Slagelse, Slagelse; Department of Rheumatology, Odense University Hospital, Odense; Department of Medicine, Hospital of South West Jutland, Esbjerg; Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Glostrup, Glostrup, Denmark.L.M. Ørnbjerg, MD; M. Østergaard, MD, PhD, DMSc; A. Thormann, MD; M.L. Hetland, MD, PhD, DMSc, DANBIO registry and Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; N.S. Krogh, consultant, Zitelab Aps; U. Tarp, MD, DMSc, Department of Rheumatology, Aarhus University Hospital; U.E. Poulsen, MD, Rheumatism Hospital, University of Southern Denmark; J. Espesen, MD, Department of Internal Medicine, Lillebælt Hospital; A. Schlemmer, MD, Department of Rheumatology, Århus University Ho
authors.forename: Merete Lund
authors.initials: ML
authors.lastname: Hetland
mesh_terms: D000068879:Adalimumab; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism*; D003718:Denmark; D018450:Disease Progression; D000068800:Etanercept; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D011859:Radiography; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D012042:Registries; D012044:Regression Analysis; D012189:Retrospective Studies; D012217:Rheumatoid Factor / Q000378:metabolism*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018501:Antirheumatic Agents; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D012217:Rheumatoid Factor; D000069285:Infliximab; D000068879:Adalimumab; D000068800:Etanercept
keywords: ANTI-TNF; EPIDEMIOLOGY; RADIOGRAPHIC PROGRESSION; RHEUMATOID ARTHRITIS