title: Treatment of Paederus Dermatitis with Sambucus ebulus Lotion.
abstract: Paederus dermatitis is an irritant contact dermatitis due to accidental contact by a beetle belonging to the genus paederus. In this study, clinical efficacies of S. ebulus fruit extract solution in patients affected by paederus dermatitis were evaluated. A randomized double-blind, prospective, placebo-controlled clinical trial was performed in 62 patients with clinical symptoms and sings of dermatitis due to paederus beetles. The patients received either a topical solution of palemolin (a 5% S. ebulus fruit extract in ethanol 70%) or ethanol 70% topical solution thrice a day. Topical hydrocortisone ointment was prescribed for all patients. Palemolin was statistically more effective in controlling of burning, pain, inflammation, drying the wound, infections and acceleration of healing than control group (p ≤ 0.05). Specially in controlling of inflammation, palemolin had more significant efficacy (p < 0.001) than control group. About 63.6% of patients in palemolin group cured during first 24 h (versus 27.4% in control groups). The problems related to lesions in 93.9% of patients were eliminated completely during 48 hours after the beginning of the treatment by palemolin (versus 65.4% in control groups). Topical 5% solution of S. ebulus fruit extract is an effective pharmaceutical preparation in treatment of paederus dermatitis.
authors.affiliation: Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ebrahimzadeh
authors.affiliation: Pharmaceutical Sciences Research Center, Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Rafati
authors.affiliation: Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Damchi
authors.affiliation: Department of Dermatology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mosoud
authors.initials: M
authors.lastname: Golpur
authors.affiliation: Department of Pharmacognosy, S chool of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Fathiazad
keywords: Erythema; Inflammation; Itching; Paederus dermatitis; Sambucus ebulus