title: Factors predictive of endometrial carcinoma in patients with atypical endometrial hyperplasia on preoperative histology.
abstract: OBJECTIVE
  To identify predictive factors of endometrial cancer in patients with atypical endometrial hyperplasia (AEH).
  
  
  METHODS
  This was a retrospective cohort study of 79 patients diagnosed with AEH. Clinicopathological characteristics of patients and final histology on hysterectomy were reviewed and univariate and multivariate analyses were performed.
  
  
  RESULTS
  Nineteen cases of endometrial cancer (24%) were diagnosed at final histology. Most patients had IA (n=15, 79%) grade 1 (n=15, 79%) cancer, but two had FIGO stage IIIC (10.5%). The predictive factors of endometrial cancer on final histology in univariate analysis were: hysteroscopic sampling, older age, post-menopausal status, suspicion of cancer on hysteroscopy and suspicion of cancer at histology. In multivariable analysis, the only predictive factors of endometrial cancer were older age and the suspicion of cancer on hysteroscopy.
  
  
  CONCLUSIONS
  In patients with AEH on biopsy, our results showed that hysteroscopy could be performed both to assess macroscopic features of malignancy and to orient biopsy.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, Paris, France cyril.touboul@gmail.com cyril.touboul@gmail.com.
authors.forename: Cyril
authors.initials: C
authors.lastname: Touboul
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, Paris, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Piel
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Bichat, Assistance Publique des Hôpitaux de Paris, Paris, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Koskas
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Bichat, Assistance Publique des Hôpitaux de Paris, Paris, France.
authors.forename: Clémentine
authors.initials: C
authors.lastname: Gonthier
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, Paris, France Inserm Unit 938, université Pierre et Marie Curie, Paris VI, Paris, France.
authors.forename: Marcos
authors.initials: M
authors.lastname: Ballester
authors.affiliation: Department of Pathology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, Paris, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Cortez
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Université Pierre et Marie Curie Paris VI, Paris, France Inserm Unit 938, université Pierre et Marie Curie, Paris VI, Paris, France Institut Universitaire de Cancérologie, Paris VI, Paris, France.
authors.forename: Emile
authors.initials: E
authors.lastname: Daraï
mesh_terms: D000368:Aged; D001706:Biopsy; D004714:Endometrial Hyperplasia / Q000150:complications* / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008593:Menopause; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Atypical endometrial hyperplasia; endometrial biopsy; endometrial cancer; hysteroscopy