title: LIGHT-SABRE enables efficient in-magnet catalytic hyperpolarization.
abstract: Nuclear spin hyperpolarization overcomes the sensitivity limitations of traditional NMR and MRI, but the most general method demonstrated to date (dynamic nuclear polarization) has significant limitations in scalability, cost, and complex apparatus design. As an alternative, signal amplification by reversible exchange (SABRE) of parahydrogen on transition metal catalysts can hyperpolarize a variety of substrates, but to date this scheme has required transfer of the sample to low magnetic field or very strong RF irradiation. Here we demonstrate "Low-Irradiation Generation of High Tesla-SABRE" (LIGHT-SABRE) which works with simple pulse sequences and low power deposition; it should be usable at any magnetic field and for hyperpolarization of many different nuclei. This approach could drastically reduce the cost and complexity of producing hyperpolarized molecules.
authors.affiliation: Department of Chemistry, Duke University, 124 Science Drive, Durham, NC 27708, USA.
authors.forename: Thomas
authors.initials: T
authors.lastname: Theis
authors.affiliation: Department of Radiology, Vanderbilt University, Institute of Imaging Science, 1161 21st Ave South MCN AA-1105, Nashville, TN 37232, USA.
authors.forename: Milton
authors.initials: M
authors.lastname: Truong
authors.affiliation: Department of Radiology, Vanderbilt University, Institute of Imaging Science, 1161 21st Ave South MCN AA-1105, Nashville, TN 37232, USA.
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Coffey
authors.affiliation: Department of Radiology, Vanderbilt University, Institute of Imaging Science, 1161 21st Ave South MCN AA-1105, Nashville, TN 37232, USA; Departments of Biochemistry and Biomedical Engineering, Vanderbilt University, Institute of Imaging Science, 1161 21st Ave South MCN AA-1105, Nashville, TN 37232, USA.
authors.forename: Eduard Y
authors.initials: EY
authors.lastname: Chekmenev
authors.affiliation: Department of Chemistry, Duke University, 124 Science Drive, Durham, NC 27708, USA; Departments of Radiology, Biomedical Engineering and Physics, Duke University, 124 Science Drive, Durham, NC 27708, USA. Electronic address: warren.warren@duke.edu.
authors.forename: Warren S
authors.initials: WS
authors.lastname: Warren
mesh_terms: D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry* / Q000528:radiation effects; D007495:Iridium / Q000737:chemistry* / Q000528:radiation effects; D060526:Magnetic Fields; D011725:Pyridines / Q000737:chemistry* / Q000528:radiation effects; D011829:Radiation Dosage; D026082:Singlet Oxygen / Q000737:chemistry* / Q000528:radiation effects; D013113:Spin Labels
chemical_list: D011725:Pyridines; D013113:Spin Labels; D026082:Singlet Oxygen; D007495:Iridium; D006859:Hydrogen; C023666:pyridine
keywords: Hyperpolarization; Magnetic properties; NMR and MRI; NMR spectroscopy; Parahydrogen