title: Characterization of four new antifungal yanuthones from Aspergillus niger.
abstract: Four new yanuthone analogs (1-4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with (13)C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1-3)) and a class II yanuthone, which was named yanuthone X2 (4). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
authors.affiliation: Chemodiversity Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Lene M
authors.initials: LM
authors.lastname: Petersen
authors.affiliation: Eukaryotic Molecular Cell Biology Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Dorte K
authors.initials: DK
authors.lastname: Holm
authors.affiliation: Fungal Physiology and Biotechnology Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Peter B
authors.initials: PB
authors.lastname: Knudsen
authors.affiliation: Metabolic Signaling and Regulation Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Kristian F
authors.initials: KF
authors.lastname: Nielsen
authors.affiliation: Department of Chemistry, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Charlotte H
authors.initials: CH
authors.lastname: Gotfredsen
authors.affiliation: Eukaryotic Molecular Cell Biology Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Uffe H
authors.initials: UH
authors.lastname: Mortensen
authors.affiliation: Chemodiversity Group, Department of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark.
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Larsen
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001234:Aspergillus niger / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000935:Antifungal Agents