title: Safety assessment of 6-hydroxyindole as used in cosmetics.
abstract: The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 6-hydroxyindole, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that 6-hydroxyindole is safe for use in oxidative hair dye formulations.
authors.affiliation: Cosmetic Ingredient Review Scientific Analyst/Writer, Washington, DC, USA.
authors.forename: Christina L
authors.initials: CL
authors.lastname: Burnett
authors.affiliation: Cosmetic Ingredient Review Chemist, Washington, DC, USA.
authors.forename: Bart
authors.initials: B
authors.lastname: Heldreth
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Donald V
authors.initials: DV
authors.lastname: Belsito
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Hill
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Curtis D
authors.initials: CD
authors.lastname: Klaassen
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Liebler
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Marks
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Shank
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Slaga
authors.affiliation: Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
authors.forename: Paul W
authors.initials: PW
authors.lastname: Snyder
authors.affiliation: Former Director, Cosmetic Ingredient Review, Washington, DC, USA.
authors.forename: F Alan
authors.initials: FA
authors.lastname: Andersen
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D003257:Consumer Product Safety; D003358:Cosmetics / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006202:Hair Dyes / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000097:blood / Q000737:chemistry / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D003358:Cosmetics; D006202:Hair Dyes; D007211:Indoles; C571206:6-hydroxyindole
keywords: 6-Hydroxyindole; cosmetics; safety