title: Sepsis: an update.
abstract: This paper aims to provide an update on the main aspects of sepsis, a very relevant health care issue. A number of hypotheses have been proposed to explain its origin, involving interactions between microorganisms and the innate immune system, inflammation/immune mediation and the coagulation system. The clinical features of sepsis are variable and depend on the primary site of infection. The identification of early signs and symptoms is crucial for starting therapeutic measures fundamentally based on volume resuscitation, antibiotic therapy, use of steroids, anticoagulant therapy, biologic viability maintenance interventions and nutritional support.
authors.affiliation: Universidade Federal de Viçosa, Viçosa, MG, Brasil.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Siqueira-Batista
authors.affiliation: Universidade Federal de Viçosa, Viçosa, MG, Brasil.
authors.forename: Andréia Patrícia
authors.initials: AP
authors.lastname: Gomes
authors.forename: Larissa
authors.initials: L
authors.lastname: Calixto-Lima
authors.affiliation: Centro Universitário Serra dos Órgãos, Teresópolis, RJ, Brasil.
authors.forename: Rodrigo Roger
authors.initials: RR
authors.lastname: Vitorino
authors.affiliation: Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
authors.forename: Mario Castro Alvarez
authors.initials: MC
authors.lastname: Perez
authors.affiliation: Universidade Federal de Viçosa, Viçosa, MG, Brasil.
authors.forename: Eduardo Gomes de
authors.initials: EG
authors.lastname: Mendonça
authors.affiliation: Universidade Federal de Viçosa, Viçosa, MG, Brasil.
authors.forename: Maria Goreti de Almeida
authors.initials: MG
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Viçosa, Viçosa, MG, Brasil.
authors.forename: Mauro
authors.initials: M
authors.lastname: Geller