title: Staging and evaluation of neoadjuvant chemotherapy response with ¹⁸F-FDG PET/CT in NUT-midline carcinoma in a child: a case report and review of the literature.
abstract: NUT midline carcinoma (NMC) is a newly defined and lethal cancer with aggressive course. It mostly affects children and young adults. Diagnosis is confirmed with the evidence of BRD4-NUT mutation on the chromosome 15q14 by fluorescence in situ hybridization. Use of (18)F-FDG PET/CT in NMC patients is very limited in the literature. In this report, we describe a 7-year-old boy with the diagnosis of NMC who was scanned with (18)F-FDG PET/CT for staging and treatment response evaluation after the chemotherapy. It was disseminated and had moderate FDG avidity in the initial scan and showed progression after 4 cycles of chemotherapy. We also reviewed the literature related to (18)F-FDG PET/CT in staging and assessment of chemotherapy response of NMC.
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: esalkan@yahoo.com.
authors.forename: E
authors.initials: E
authors.lastname: Ciftci
authors.affiliation: Department of Pediatric Oncology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: udemirsoy@yahoo.com.
authors.forename: U
authors.initials: U
authors.lastname: Demirsoy
authors.affiliation: Department of Radiology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: yonca.anik@kocaeli.edu.tr.
authors.forename: Y
authors.initials: Y
authors.lastname: Anik
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: gozdedaglioz@yahoo.com.
authors.forename: G
authors.initials: G
authors.lastname: Gorur
authors.affiliation: Department of Pediatric Oncology, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: fundacorapcioglu@yahoo.com.
authors.forename: F
authors.initials: F
authors.lastname: Corapcioglu
authors.affiliation: Department of Nuclear Medicine, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey. Electronic address: hakandemir99@yahoo.com.
authors.forename: H
authors.initials: H
authors.lastname: Demir
mesh_terms: D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D002277:Carcinoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy / Q000556:secondary; D002648:Child; D018450:Disease Progression; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging / Q000379:methods*; D009687:Nuclear Proteins / Q000235:genetics; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D010166:Palliative Care; D000072078:Positron Emission Tomography Computed Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013899:Thoracic Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000235:genetics / Q000532:radiotherapy
chemical_list: C471990:BRD4-NUT fusion oncogene protein, human; D005462:Fluorine Radioisotopes; D009687:Nuclear Proteins; D015514:Oncogene Proteins, Fusion; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: (18)F-FDG PET/CT; (18)F-FDG PET/TAC; Carcinoma de línea media – NUT; Children; Evaluación de la respuesta; NUT midline carcinoma; Niños; Response evaluation