title: Pericentrin: critical for spindle orientation.
abstract: Mutations in the pericentrin (PCNT) gene cause Majewski osteodysplastic primordial dwarfism type II (MOPDII). Recent work reveals that a discrete set of centrosome proteins require PCNT for their robust localization to mitotic spindle poles. Critically, this complex is crucial for mitotic spindle orientation and involved in the pathogenesis of MOPDII.
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: pelletier@lunenfeld.ca.
authors.forename: Laurence
authors.initials: L
authors.lastname: Pelletier
mesh_terms: D000818:Animals; D000941:Antigens / Q000235:genetics*; D004392:Dwarfism / Q000235:genetics*; D005317:Fetal Growth Retardation / Q000235:genetics*; D006801:Humans; D008831:Microcephaly / Q000235:genetics*; D008870:Microtubules / Q000235:genetics*; D008938:Mitosis; D010009:Osteochondrodysplasias / Q000235:genetics*; D008941:Spindle Apparatus / Q000235:genetics*
chemical_list: D000941:Antigens; C086178:pericentrin