title: Urinary TGF-1 has a supplementary value in predicting renal function recovery post unilateral ureteral obstruction.
abstract: OBJECTIVE
  To evaluate whether urine transforming growth factor-β1 (TGF-β1) can help identifying kidneys that would recover their function after drainage of unilateral ureteric obstructive.
  
  
  METHODS
  Forty-five patients with unilateral ureteral obstruction were included. Glomerular filtration rate (GFR) of the obstructed kidney was <10 ml/min, and all patients were treated with percutaneous nephrostomy. TGF-β1 level was measured in the urine from the obstructed kidney at the time of drainage. GFR before nephrostomy insertion and 3 months after were calculated.
  
  
  RESULTS
  Patients with renal function improvement (significant increase in GFR) after nephrostomy insertion had significantly lower concentration of urine TGF-β1 (p<0.05) compared with the group that showed no change in GFR (non-functioning kidneys) The sensitivity, specificity and accuracy of urine TGF-β1 in identifying non-functioning kidney was 82, 82 and 82%, respectively.
  
  
  CONCLUSIONS
  Urine TGF-β1 is a cytokine leading to renal fibrosis and has a supplementary value in differentiating, at early stage, between kidneys that would recover function after releasing unilateral ureteral obstruction from those which will not (non-functioning kidneys).
authors.affiliation: Department of Urology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, 210008, China.
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Samih
authors.initials: S
authors.lastname: Al-Hayek
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.forename: Chunming
authors.initials: C
authors.lastname: Jiang
authors.forename: Xi
authors.initials: X
authors.lastname: Zheng
authors.forename: Hongqian
authors.initials: H
authors.lastname: Guo
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000652:urine; D004322:Drainage; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D020127:Recovery of Function; D051437:Renal Insufficiency / Q000209:etiology / Q000503:physiopathology*; D053773:Transforming Growth Factor beta1 / Q000652:urine*; D014514:Ureteral Calculi / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D014517:Ureteral Obstruction / Q000150:complications / Q000503:physiopathology* / Q000601:surgery
chemical_list: D015415:Biomarkers; D053773:Transforming Growth Factor beta1