title: XAGE-1bexpression is associated with the diagnosis and early recurrence of hepatocellular carcinoma.
abstract: XAGE-1bis a 470 bp transcript of theXAGE-1gene, which belongs to the cancer-testis antigens that exhibit a restricted pattern of expression in normal tissues. Recently, the expression ofXAGE-1bhas been shown to be frequent in patients with hepatocellular carcinoma (HCC). However, the underlying mechanism is not fully understood. To investigate the role ofXAGE-1bin HCC diagnosis and postoperative evaluation, the expression level ofXAGE-1bwas first examined in the tissue and peripheral blood of HCC patients and controls by using quantitative polymerase chain reaction. Subsequently, the associations betweenXAGE-1band the clinical variables were assessed using χ2or Kaplan-Meier tests. The data showed that HCC tissues had increasedXAGE-1bexpression when compared to paired non-tumorous tissues. The blood samples from the HCC patients showed upregulatedXAGE-1bmRNA, as compared to non-HCC patients. The patients with portal vein tumor thrombus or higher tumor-node metastasis stages (II~IV) were more likely to have increased levels ofXAGE-1bmRNA. Furthermore, the 1-year recurrence rate of the patients with a high level ofXAGE-1bmRNA was significantly greater compared to the patients with a low level. All these findings indicate thatXAGE-1bis associated with the aggressive biological behavior of HCC cells and it may be a potential biomarker for HCC diagnosis and prognosis.
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Zeya
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Department of Life Science, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
authors.forename: Bikui
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of General Surgery, 153 Central Hospital of PLA, Zhengzhou, Henan 450007, P.R. China.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Hou
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Yang
authors.affiliation: The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, P.R. China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhou
keywords: XAGE-1b; cancer biomarker; diagnosis; hepatocellular carcinoma; prognosis