title: [Beneficial effect of preferred music on cognitive functions in minimally conscious state patients].
abstract: Several studies have shown that music can boost cognitive functions in normal and brain-damaged subjects. A few studies have suggested a beneficial effect of music in patients with a disorder of consciousness but it is difficult to conclude since they did not use quantified measures and a control condition/group. The aim of the present study was to compare the effect of music to that of a continuous sound on the relational behavior of patients in a minimally conscious state (MCS). Behavioral responses of six MCS patients were evaluated using items from the Coma Recovery Scale-Revised. Weekly evaluation sessions were carried out, over four weeks, under two conditions: following the presentation of either the patient's preferred music, or following a continuous sound (control condition). Qualitative and quantitative analyses showed that twelve of the eighteen sessions (66.6%) showed a better result for the music condition than for the control condition. This new protocol suggests that preferred music has a beneficial effect on the cognitive abilities of MCS patients. The results further suggest that cerebral plasticity may be enhanced in autobiographical (emotional and familiar) contexts. These findings should now be further extended with an increased number of patients to further validate the hypothesis of the beneficial effect of music on cognitive recovery.
authors.affiliation: Équipe cognition auditive et psychoacoustique, université Lyon 1, CNRS UMR5292, inserm U1028, centre de recherche en neurosciences de Lyon, 50 avenue Tony-Garnier, 69366 Lyon cedex 07, France; Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France.
authors.forename: J
authors.initials: J
authors.lastname: Verger
authors.affiliation: Équipe cognition auditive et psychoacoustique, université Lyon 1, CNRS UMR5292, inserm U1028, centre de recherche en neurosciences de Lyon, 50 avenue Tony-Garnier, 69366 Lyon cedex 07, France; Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France.
authors.forename: S
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: Équipe cognition auditive et psychoacoustique, université Lyon 1, CNRS UMR5292, inserm U1028, centre de recherche en neurosciences de Lyon, 50 avenue Tony-Garnier, 69366 Lyon cedex 07, France.
authors.forename: B
authors.initials: B
authors.lastname: Tillmann
authors.affiliation: Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France.
authors.forename: M
authors.initials: M
authors.lastname: Ben Romdhane
authors.affiliation: Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France.
authors.forename: M
authors.initials: M
authors.lastname: De Quelen
authors.affiliation: Équipe cognition auditive et psychoacoustique, université Lyon 1, CNRS UMR5292, inserm U1028, centre de recherche en neurosciences de Lyon, 50 avenue Tony-Garnier, 69366 Lyon cedex 07, France.
authors.forename: M
authors.initials: M
authors.lastname: Castro
authors.affiliation: Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France.
authors.forename: L
authors.initials: L
authors.lastname: Tell
authors.affiliation: Service de médecine physique et de réadaptation, hôpital Henry Gabrielle, 20, route de Vourles, 69230 Saint Genis Laval, France; Équipe IMPACT, inserm U1028, université Lyon 1, CNRS UMR5292, centre de recherche en neurosciences de Lyon, 16, avenue du Doyen-Lépine, 69675 Bron cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Luauté
authors.affiliation: Équipe cognition auditive et psychoacoustique, université Lyon 1, CNRS UMR5292, inserm U1028, centre de recherche en neurosciences de Lyon, 50 avenue Tony-Garnier, 69366 Lyon cedex 07, France. Electronic address: fabien.perrin@univ-lyon1.fr.
authors.forename: F
authors.initials: F
authors.lastname: Perrin
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000628:therapy; D003071:Cognition; D003128:Coma / Q000523:psychology; D005260:Female; D006801:Humans; D002534:Hypoxia, Brain / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009147:Music Therapy / Q000379:methods*; D018458:Persistent Vegetative State / Q000523:psychology* / Q000628:therapy*; D020127:Recovery of Function; D020521:Stroke / Q000150:complications / Q000628:therapy; D016896:Treatment Outcome
keywords: Cognitive abilities; Coma Recovery Scale-Revised; Fonctions cognitives; Minimally conscious state; Music; Musique; État de conscience minimale