title: Endocrine disruptive compounds and cardio-metabolic risk factors in children.
abstract: The endocrine disrupting chemicals (EDC) are exogenous chemicals that can disrupt hormonal signaling system. EDCs are ubiquitous in our environment and many EDC are detectable in humans. With the increasing obesity prevalence in children it is imperative to explore the role of EDC as obesogens. This review summarizes recent epidemiological evidence regarding impact of these EDC on weight gain and metabolic outcomes in children. The EDCs include pharmaceuticals, pesticides, industrial by-products, and cigarette smoke. Current evidence suggests a link between early life exposure to some industrial by-products, synthetic hormones and cigarette smoke with weight gain. However, there is inconclusive evidence of an association between exposure to fungicides, dioxin, phytoestrogens, flame retardants, heavy metals and childhood obesity.
authors.affiliation: 3123 Research Blvd., Suite #200, Center for Global Health, Department of Community Health, Wright State University, Boonshoft School of Medicine, Dayton, OH, USA. Electronic address: naila.khalil@wright.edu.
authors.forename: Naila
authors.initials: N
authors.lastname: Khalil
authors.affiliation: Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
authors.forename: Aimin
authors.initials: A
authors.lastname: Chen
authors.affiliation: Lifespan Health Research Center, Department of Community Health, Wright State University, Boonshoft School of Medicine, Dayton, OH 45420-4006, USA; Department of Pediatrics, Wright State University, Boonshoft School of Medicine, Dayton, OH 45404-1815, USA.
authors.forename: Miryoung
authors.initials: M
authors.lastname: Lee
mesh_terms: D000818:Animals; D002648:Child; D052244:Endocrine Disruptors / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D063766:Pediatric Obesity / Q000209:etiology*; D012307:Risk Factors; D012906:Smoke / Q000009:adverse effects; D014026:Nicotiana; D015430:Weight Gain / Q000187:drug effects
chemical_list: D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D012906:Smoke