title: MicroRNAs associated with HBV infection and HBV-related HCC.
abstract: Hepatitis B virus (HBV) infection is a global problem and a major risk factor for hepatocellular carcinoma (HCC). microRNAs (miRNAs) comprise a group of small noncoding RNAs regulating gene expression at the posttranslational level, thereby participating in fundamental biological processes, including cell proliferation, differentiation, and apoptosis. In this review, we summarize the roles of miRNAs in HBV infection, the recently identified mechanism underlying dysregulation of miRNAs in HBV-associated HCC, and their association with hepatocarcinogenesis. Moreover, we discuss the recent advances in the use of circulating miRNAs in the early diagnosis of HCC as well as therapies based on these aberrantly expressed miRNAs.
authors.affiliation: 1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
authors.forename: Kun-Lin
authors.initials: KL
authors.lastname: Xie
authors.affiliation: 2. The Department of Burns and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China;
authors.forename: Yan-Ge
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: 3. The Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.affiliation: 1. The Department of Liver Surgery & Liver Transplantation Centre, West China Hospital, Sichuan University, Chengdu, 610041, China;
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006509:Hepatitis B / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D006515:Hepatitis B virus / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000821:virology; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
keywords: Diagnosis; Hepatitis B virus; Hepatocellular carcinoma; MicroRNA; Therapy.