title: Transgenic mouse model of cutaneous adnexal tumors.
abstract: TMEM207 was first characterized as being an important molecule for the invasion activity of gastric signet-ring cell carcinoma cells. In order to unravel the pathological properties of TMEM207, we generated several transgenic mouse lines, designated C57BL/6-Tg (ITF-TMEM207), in which murine TMEM207 was ectopically expressed under a truncated (by ~200 bp) proximal promoter of the murine intestinal trefoil factor (ITF) gene (also known as Tff3). Unexpectedly, a C57BL/6-Tg (ITF-TMEM207) mouse line exhibited a high incidence of spontaneous intradermal tumors with histopathological features that resembled those of various human cutaneous adnexal tumors. These tumors were found in ~14% female and 13% of male 6- to 12-month-old mice. TMEM207 immunoreactivity was found in hair follicle bulge cells in non-tumorous skin, as well as in cutaneous adnexal tumors of the transgenic mouse. The ITF-TMEM207 construct in this line appeared to be inserted to a major satellite repeat sequence at chromosome 2, in which no definite coding molecule was found. In addition, we also observed cutaneous adnexal tumors in three other C57BL/6-Tg (ITF-TMEM207) transgenic mouse lines. We believe that the C57BL/6-Tg (ITF-TMEM207) mouse might be a useful model to understand human cutaneous adnexal tumors.
authors.affiliation: Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu 501-1194, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kito
authors.affiliation: Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu 501-1194, Japan.
authors.forename: Chiemi
authors.initials: C
authors.lastname: Saigo
authors.affiliation: Department of Pathology, Kochi Medical School, Nankoku 783-8505, Japan.
authors.forename: Kurabayashi
authors.initials: K
authors.lastname: Atsushi
authors.affiliation: Department of Pathology, Kochi Medical School, Nankoku 783-8505, Japan.
authors.forename: Furihata
authors.initials: F
authors.lastname: Mutsuo
authors.affiliation: Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu 501-1194, Japan. takeutit08@gmail.com.
authors.forename: Takeuchi
authors.initials: T
authors.lastname: Tamotsu
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018294:Neoplasms, Adnexal and Skin Appendage / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; C571895:TMEM207 protein, human; C000600503:TMEM207 protein, mouse
keywords: Cutaneous adnexal tumor; Mouse model; TMEM207