title: Additional intranasal oxytocin to escitalopram improves depressive symptoms in resistant depression: an open trial.
abstract: The aim of this open trial was to assess the antidepressant/anxiolytic effects of oxytocin used as an adjunct to antidepressant in treatment-resistant depression. Fourteen patients, who have not responded to 40mg of escitalopram, received intranasal synthetic oxytocin during 4 weeks, in association with antidepressant. This is the first open trial study suggesting OT in association with escitalopram significantly reduced scores on Hamilton Depression Rating Scale.
authors.affiliation: Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium. Electronic address: Gabrielle.Scantamburlo@ulg.ac.be.
authors.forename: G
authors.initials: G
authors.lastname: Scantamburlo
authors.affiliation: Department of Cognitive Sciences, Faculty of Psychology, University of Liège, Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Hansenne
authors.affiliation: Immunoendocrinology Center, GIGA3, University of Liège, Liège, Belgium.
authors.forename: V
authors.initials: V
authors.lastname: Geenen
authors.affiliation: Departement of Endocrinology, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium.
authors.forename: J J
authors.initials: JJ
authors.lastname: Legros
authors.affiliation: Department of Psychiatry, Psychoneuroendocrinology Unit, University of Liège, Liège, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Ansseau
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy* / Q000517:prevention & control; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy* / Q000523:psychology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010121:Oxytocin / Q000008:administration & dosage*; D011569:Psychiatric Status Rating Scales; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram; D010121:Oxytocin
keywords: Anxiety; Intranasal oxytocin; Major depression