title: Uracil-DNA glycosylase (UNG) rs246079 G/A polymorphism is associated with decreased risk of esophageal cancer in a Chinese population.
abstract: Esophageal cancer is the sixth leading cause of cancer-associated death worldwide. In addition to environmental risk factors, genetic factors might play an important role in esophageal cancer carcinogenesis. We conducted a hospital-based case-control study to evaluate the association between functional single nucleotide polymorphisms (SNPs) in uracil-DNA glycosylase (UNG) and the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The UNG rs3219218 A/G and UNG rs246079 G/A genotypes were determined using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). When the UNG rs246079 GG homozygote genotype was used as the reference group, the GA genotype was associated with a significantly decreased risk for ESCC (GA vs. GG: adjusted OR 0.67, 95 % CI 0.49-0.91, P = 0.011); the AA genotype was not associated with the risk of ESCC. In stratification analyses, a significantly decreased risk of ESCC associated with the UNG rs246079 G/A polymorphism was evident among women, younger patients and never-smokers and never-drinkers. The UNG rs3219218 A/G polymorphism was not associated with the risk for ESCC. These findings indicated that UNG rs246079 G/A might contribute to a decreased risk of ESCC in specific populations. Because of the limited sample size, further studies including a larger and more diverse population, as well as tissue-specific biological characterization, are required to confirm the current findings.
authors.affiliation: Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, 8 Dianli Rd, Zhenjiang, 212000, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Sang
authors.forename: Liang
authors.initials: L
authors.lastname: Zheng
authors.forename: Liming
authors.initials: L
authors.lastname: Wang
authors.forename: Luorongxin
authors.initials: L
authors.lastname: Yuan
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Yijun
authors.initials: Y
authors.lastname: Shi
authors.forename: Aizhong
authors.initials: A
authors.lastname: Shao
authors.forename: Guowen
authors.initials: G
authors.lastname: Ding
authors.forename: Suocheng
authors.initials: S
authors.lastname: Chen
authors.forename: Weifeng
authors.initials: W
authors.lastname: Tang
authors.forename: Haiyong
authors.initials: H
authors.lastname: Gu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance; D012307:Risk Factors; D051981:Uracil-DNA Glycosidase / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D051981:Uracil-DNA Glycosidase