title: [Human interferon modulates infected vascular endothelium function].
abstract: BACKGROUND
  To study impact of interferon (IFN) alpha, beta and gamma on the Herpes simplex virus type 1 (HSV-1) infected endothelial cells functional activity related with participation in the inflammation development.
  
  
  METHODS
  In the work endothelial cells isolated from umbilical vein were used. Intact and infected cultures were treated by interferon and in the dynamics of cultivation tested mediators in the cultural medium.
  
  
  RESULTS
  All investigated interferons activated the production of IL-6. IFN alpha, beta activated the production of IL-8, while IFN gamma inhibited her. IFN alpha and gamma increased synthesis of nitrogen oxides and reduced the synthesis of endothelin-1, while IFN beta activated the production of endothelin-1.
  
  
  CONCLUSIONS
  Infection of endothelial cells isolated from umbilical vein with HSV-1 does not alter the ability of interferon in modulating of proinflammatory cytokines, nitric oxide and endothelin-1 synthesis. It is obvious in the body modulation manifestations of innate immunity under the influence of exogenous interferon is implemented both intact and infected with HSV-1-vascular endothelium and nature modulation is determined by the type of IFN.
authors.forename: O N
authors.initials: ON
authors.lastname: Shcheglovitova
authors.forename: N N
authors.initials: NN
authors.lastname: Skliankina
authors.forename: N V
authors.initials: NV
authors.lastname: Boldyreva
authors.forename: A A
authors.initials: AA
authors.lastname: Babaiants
authors.forename: I S
authors.initials: IS
authors.lastname: Frolova
authors.forename: M P
authors.initials: MP
authors.lastname: Kapkaeva
mesh_terms: D002478:Cells, Cultured; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000472:pathogenicity*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D018836:Inflammation Mediators / Q000502:physiology; D007372:Interferons / Q000145:classification / Q000276:immunology / Q000494:pharmacology; D015850:Interleukin-6 / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D014471:Umbilical Veins
chemical_list: D019332:Endothelin-1; D018836:Inflammation Mediators; D015850:Interleukin-6; D016209:Interleukin-8; D009569:Nitric Oxide; D007372:Interferons