title: Transplantation of bone marrow stem cells during cardiac surgery.
abstract: This systematic review with meta-analysis sought to determine the efficacy and safety of intramyocardial transplantation of bone marrow stem cells during coronary artery bypass graft surgery on postoperative cardiac functional parameters such as left ventricular ejection fraction and left ventricular end-diastolic volume.
  
  
  
  Medline/PubMed, Embase, Elsevier, Sciences online database, and Google Scholar literature search were searched. The effect sizes measured were risk ratio for categorical variables and weighted mean difference with 95% confidence interval for calculating differences between mean values of baseline and follow-up cardiac functional parameters. A value of p < 0.1 for Q test, or I(2 )> 50%, indicated significant heterogeneity among studies. The literature search retrieved 2900 studies from screened databases, of which 2866 (98.6%) were excluded and 34 (619 patients) were included for scoping review. The final analysis included 9 studies (335 patients).
  
  
  
  Pooled effects estimates of left ventricular ejection fraction and left ventricular end-diastolic volume showed that bone marrow stem cell transplantation had a weighted mean difference of 4.06 (95% confidence interval: 0.41-7.72; p = 0.02) and 7.06 (95% confidence interval: -8.58-22.7; p = 0.3), respectively.
  
  
  
  Intramyocardial transplantation of bone marrow stem cells improves cardiac functional parameters, significantly increasing left ventricular ejection fraction with a nonsignificant reduction in left ventricular end-diastolic volume. Also, this therapeutic method has no life-threatening complications and was therefore found to be an effective and safe method.
authors.affiliation: Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran S.alihassan.cardiosurg@gmail.com.
authors.forename: Sadeq
authors.initials: S
authors.lastname: Ali-Hasan-Al-Saegh
authors.affiliation: Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Seyed Jalil
authors.initials: SJ
authors.lastname: Mirhosseini
authors.affiliation: Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Lotfaliani
authors.affiliation: Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Dehghan
authors.affiliation: Department of Medicine III, University of Heidelberg, Heidelberg, Germany.
authors.forename: Farbod
authors.initials: F
authors.lastname: Sedaghat-Hamedani
authors.affiliation: Department of Medicine III, University of Heidelberg, Heidelberg, Germany.
authors.forename: Elham
authors.initials: E
authors.lastname: Kayvanpour
authors.affiliation: Cardiovascular Research Center, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rezaeisadrabadi
authors.affiliation: Department of Cardiovascular Surgery, Herzchirurgie Klinikum, Karlsruhe, Germany.
authors.forename: Naser
authors.initials: N
authors.lastname: Ghaffari
authors.affiliation: Department of Cardiovascular Surgery, Herzchirurgie Klinikum, Karlsruhe, Germany.
authors.forename: Vahid
authors.initials: V
authors.lastname: Vahabzadeh
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University Hospital Goettingen, Goettingen, Germany.
authors.forename: Ahamd Fawad
authors.initials: AF
authors.lastname: Jebran
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, London, UK.
authors.forename: Anton
authors.initials: A
authors.lastname: Sabashnikov
authors.affiliation: Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton & Harefield NHS Foundation Trust, London, UK.
authors.forename: Aron-Frederik
authors.initials: AF
authors.lastname: Popov
mesh_terms: D001854:Bone Marrow Cells / Q000166:cytology*; D016026:Bone Marrow Transplantation / Q000379:methods*; D006348:Cardiac Surgical Procedures / Q000379:methods*; D001026:Coronary Artery Bypass / Q000379:methods*; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology / Q000601:surgery*; D016017:Odds Ratio; D020127:Recovery of Function; D013318:Stroke Volume; D014182:Transplantation, Autologous / Q000379:methods*; D016896:Treatment Outcome; D016277:Ventricular Function, Left
keywords: Bone marrow transplantation; coronary artery bypass; stem cell transplantation; treatment outcome