title: [Preparation and pharmacokinetic evaluation of long-acting injectable oily suspensions for ophiopogonis radix polysaccharide MDG-1].
abstract: OBJECTIVE
  To evaluate in vivo pharmacokinetics of Ophiopogonis Radix polysaccharide MDG-1 oily suspension injection prepared with different prescriptions in rats, and explore the feasibility of the long-acting drug delivery of MDG-1 Injection by using the oily suspension drug release system.
  
  
  METHODS
  MDG-1 microparticles were prepared by the anti-solvent precipitation method. Their size and size distribution were characterized. Castor oil with a high viscosity or aluminum stearate were added into soybean oil with a low viscosity, in order to prepare oily media with different viscosities, detect their rheological properties and screen out superior prescriptions for in vivo evaluation.
  
  
  RESULTS
  The average size of microparticles was 21.81 microm, and the span between them was 2.63. The in vivo evaluation was conducted for prescriptions of mixed oil (soybean oil/castor oil, 2: 3) and soybean oils gelled by 2% and 4% aluminium stearate. Among them, the prescription of soybean gelled by 4% aluminium stearate could significantly reduce C(max) and prolong the apparent t1/2, with the MDG-1 release time of several days.
  
  
  CONCLUSIONS
  It is feasible to achieve the long-acting MDG-1 drug delivery by using oily media with a high viscosity.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Shi
authors.forename: Chun-Xia
authors.initials: CX
authors.lastname: Yao
authors.forename: Xiao
authors.initials: X
authors.lastname: Lin
authors.forename: Lan
authors.initials: L
authors.lastname: Shen
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D031441:Ophiopogon / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014783:Viscosity
chemical_list: D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D011134:Polysaccharides; C517472:polysaccharide MDG-1