title: Cost analysis of use of tranexamic Acid to prevent major bleeding complications in hip and knee arthroplasty surgery.
abstract: We used decision analysis to assess the cost profile associated with preoperative use of tranexamic acid (TXA) to prevent major bleeding complications associated with hip and knee arthroplasty surgery. We defined major bleeding complications as blood loss sufficient to require transfusion or surgical evacuation of a postoperative hematoma. In the absence of a reduction in revision rates, using current cost data, TXA use is not cost-saving for institutions with baseline blood transfusion rates under 25%. For centers with baseline transfusion rates above 25%, however, TXA becomes increasingly cost-saving as the reduction in transfusion rates seen with use of the drug increases, but a minimum 12% reduction in transfusion rates is needed, even if the expected baseline transfusion rate is 100%. Nevertheless, TXA use is much more likely to be cost-saving, regardless of transfusion rates, if it leads to a reduction in need for revision surgery.
authors.affiliation: Department of Orthopaedic Surgery, New York University Langone Medical Center, New York, NY. james.slover@nyumc.org.
authors.forename: James
authors.initials: J
authors.lastname: Slover
authors.forename: Joseph
authors.initials: J
authors.lastname: Bosco
mesh_terms: D000933:Antifibrinolytic Agents / Q000191:economics* / Q000627:therapeutic use; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000191:economics*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000191:economics*; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D003365:Costs and Cost Analysis; D003661:Decision Support Techniques; D006801:Humans; D008390:Markov Chains; D019106:Postoperative Hemorrhage / Q000191:economics* / Q000517:prevention & control; D012086:Reoperation / Q000191:economics; D014148:Tranexamic Acid / Q000191:economics* / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid