title: Fasting and postprandial acyl and desacyl ghrelin levels in obese and non-obese subjects.
abstract: BACKGROUND
  The potentially differential roles of both forms of ghrelin in obesity are undefined, and little is known about desacyl ghrelin's (DAG) regulation by meals. We aimed to assess changes in acyl ghrelin (AG) and DAG in response to mixed-meal consumption in obese and non-obese subjects.
  
  
  METHODS
  Venous blood for plasma glucose, AG and DAG assays were collected in both groups after an overnight fast and two hours after the consumption of a standard 300 kcal-mixed meal (Nutridrink, Nutricia).
  
  
  RESULTS
  Mean fasting values of both AG and DAG were significantly lower in the obese individuals. On the other hand, among non-obese controls, the mean postprandial DAG levels did not change and AG levels decreased, whereas in obese individuals the mean DAG levels after a mixed-meal diminished and AG levels were unchanged.
  
  
  CONCLUSIONS
  It is necessary to distinguish between the desacylated and acylated forms of ghrelin, as we have shown differential postprandial AG and DAG responses in obese and non-obese individuals. Whether targeting changed proportions between AG and DAG could be a successful strategy in obesity treatment remains a question for future studies.
authors.affiliation: annadar@gumed.edu.pl.
authors.forename: Jolanta Anna
authors.initials: JA
authors.lastname: Dardzińska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Małgorzewicz
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Kaska
authors.forename: Monika
authors.initials: M
authors.lastname: Proczko
authors.forename: Tomasz
authors.initials: T
authors.lastname: Stefaniak
authors.forename: Marta
authors.initials: M
authors.lastname: Stankiewicz
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Śledziński
mesh_terms: D000214:Acyl Coenzyme A / Q000097:blood*; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000097:blood*; D019518:Postprandial Period / Q000502:physiology*; D012307:Risk Factors
chemical_list: D000214:Acyl Coenzyme A; D054439:Ghrelin; C422650:ghrelin, des-n-octanoyl