title: A photochemical one-pot three-component synthesis of tetrasubstituted imidazoles.
abstract: Tetrasubstituted imidazoles can be formed in a photochemical one-pot synthesis from aldehydes, α-aminonitriles, and isoxazoles. Condensation of the first two components produces α-(alkylideneamino)nitriles which react under basic conditions with the acylazirines formed in situ by photochemical ring transformation of the isoxazole component. This process includes an unusual cleavage of the C(2)-C(3) bond of the acylazirine. The reaction mechanism was studied by DFT calculations.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg University , Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Pusch
authors.forename: Till
authors.initials: T
authors.lastname: Opatz