title: TBHP-promoted sequential carboxamidation and aromatisation of aryl isonitriles with formamides.
abstract: The tert-butyl hydroperoxide (TBHP)-promoted sequential carboxamidation and aromatisation of isonitriles with formamides was developed. This procedure tolerates a series of functional groups, such as methyl, fluoro, chloro, acetyl, methoxy carbonyl and cyano. This reaction involved the addition of formamide radicals to isonitriles and sequential C-C bond formation by intramolecular aromatic cyclisation, leading to phenanthridine 6-carboxamides in moderate to good yields.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China. yujintao@cczu.edu.cn.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Feng
authors.forename: Hui
authors.initials: H
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
authors.forename: Jin-Tao
authors.initials: JT
authors.lastname: Yu
mesh_terms: D000577:Amides / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D003500:Cyclization; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D020122:tert-Butylhydroperoxide / Q000737:chemistry*
chemical_list: D000577:Amides; D002264:Carboxylic Acids; D005559:Formamides; D009570:Nitriles; D020122:tert-Butylhydroperoxide