title: Noninvasive diagnostics supporting system for choroidal melanoma: a pilot study.
abstract: OBJECTIVE
  To examine the usefulness of a near-infrared hyperspectral imager (NIR-HSI) system in discriminating uveal melanoma from other intraocular tumors.
  
  
  METHODS
  The NIR-HSI, which had been developed as a screening system for age-related macular degeneration, was used to measure near-infrared hyperspectral data (NIR-HSD) of a lesion located at the ocular fundus of 17 Japanese patients, including 5 with choroidal melanoma and 12 with other intraocular tumors. The index was derived from each NIR-HSD. Non-parametric statistical analysis was performed.
  
  
  RESULTS
  Diagnostic accuracy of 94.1% was achieved when the threshold value of the index was set to minimize the average value of false-positive and -negative fractions.
  
  
  CONCLUSIONS
  The NIR-HSI system is useful as a noninvasive diagnostic supporting system for choroidal melanoma.
authors.affiliation: Department of Electrical Engineering and Bioscience, Waseda University, Shinjuku, Tokyo, 169-8555, Japan.
authors.forename: Ori
authors.initials: O
authors.lastname: Kameyama
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Usui
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kimura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamura
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sota
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000175:diagnosis*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D055088:Early Detection of Cancer / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D008875:Middle Aged; D010781:Photography / Q000295:instrumentation*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity