title: Synthesis of 2-trifluoromethylpyrazolo[5,1-a]isoquinolines via silver triflate-catalyzed or electrophile-mediated one-pot tandem reaction.
abstract: An efficient one-pot tandem cyclization/[3 + 2] cycloaddition reaction of N'-(2-alkynylbenzylidene)hydrazides with ethyl 4,4,4-trifluorobut-2-ynoate under silver triflate-catalyzed or electrophile-mediated conditions is described. Various trifluoromethylated pyrazolo[5,1-a]isoquinolines were afforded in moderate to excellent yield by this developed method.
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of green chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of green chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
authors.forename: Meiling
authors.initials: M
authors.lastname: Liu
authors.affiliation: Department of Obstetrics and Gynecology, Jiangxi Provincial people's Hospital, Nanchang, Jiangxi 330006, P. R. China.
authors.forename: Puying
authors.initials: P
authors.lastname: Luo
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of green chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Lai
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of green chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
authors.forename: Tangtao
authors.initials: T
authors.lastname: Yang
authors.affiliation: Key Laboratory of Small Functional Organic Molecule, Ministry of Education and Jiangxi's Key Laboratory of green chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China.
authors.forename: Qiuping
authors.initials: Q
authors.lastname: Ding
keywords: N’-(2-alkynylbenzylidene)hydrazide; [3 + 2] cycloaddition; electrophile; silver triflate; tandem