title: A rare case of hepatic T-cell rich B-cell lymphoma (TCRBCL) in a juvenile dog.
abstract: A 7-month-old castrated male French Bull dog was presented with vomiting, lethargy, anorexia and weight loss of 2 weeks duration. The patient's history and clinical manifestations of suspected hepatopathy were subjected to ultrasonography, radiography, biochemical investigations and cytology of hepatic lesion. The cytologic impression was hepatic lymphoma, which was later confirmed by histopathology. The neoplastic cells were strongly diffusely immunoreactive for PAX5, but not immunoreactive for CD3, and B lymphocyte specific clonal proliferation was detected using by assay of antigen receptor rearrangement. Large numbers of immunoreactive mature non-neoplastic lymphocytes were admixed with the neoplastic cell population. Therefore, the immunohistochemical results were definitively consistent with a T-cell rich B-cell lymphoma (TCRBCL). This is the first description of a hepatic TCRBCL in a juvenile dog showing a poor response to aggressive chemotherapy.
authors.affiliation: Department of Animal Science, Joongbu University, Gumsan-gun, Chungnam 312-702, South Korea.
authors.forename: Tae-Ho
authors.initials: TH
authors.lastname: Chung
authors.forename: Catherine
authors.initials: C
authors.lastname: Lamm
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Choi
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Dohyeon
authors.initials: D
authors.lastname: Yu
authors.forename: Ul-Soo
authors.initials: US
authors.lastname: Choi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004283:Dog Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016393:Lymphoma, B-Cell / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male
chemical_list: D000970:Antineoplastic Agents