title: An evaluation of SERI surgical scaffold for soft-tissue support and repair in an ovine model of two-stage breast reconstruction.
abstract: This study was designed to evaluate the SERI Surgical Scaffold, a silk-derived bioresorbable scaffold, in an ovine model of two-stage breast reconstruction. Sheep were implanted bilaterally with either SERI or sham sutures during the stage 1 procedure. The SERI group underwent an exchange procedure for a breast implant at 3 months; animals in the sham group were killed at 3 months. The sham samples were significantly weaker than the SERI plus tissue samples by 3 months. At all endpoints, SERI plus tissue samples were greater than or equal to 150 percent of native ovine fascial strength. Histologic evaluation of SERI samples showed evidence of bioresorption through 12 months. SERI provided adequate soft-tissue support with progressive bioresorption. By 12 months, newly formed tissue had assumed the majority of load-bearing responsibility.
authors.affiliation: Los Angeles, Calif; Medford and North Grafton, Mass.; and Logan and Salt Lake City, Utah From the Keck School of Medicine, University of Southern California; Allergan, Inc.; Innovative Medical Device Solutions; the University of Utah School of Medicine; ARUP Laboratories; and the Cummings School of Veterinary Medicine, Tufts University.
authors.forename: John E
authors.initials: JE
authors.lastname: Gross
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Horan
authors.forename: Matthew
authors.initials: M
authors.lastname: Gaylord
authors.forename: Raymond E
authors.initials: RE
authors.lastname: Olsen
authors.forename: L D
authors.initials: LD
authors.lastname: McGill
authors.forename: José M
authors.initials: JM
authors.lastname: García-López
authors.forename: Kristen
authors.initials: K
authors.lastname: Biber
authors.forename: Kristen
authors.initials: K
authors.lastname: Barnico
authors.forename: Ivan
authors.initials: I
authors.lastname: Toponarski
authors.forename: Gregory
authors.initials: G
authors.lastname: Altman
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001696:Biomechanical Phenomena; D018427:Breast Implants; D005260:Female; D016462:Mammaplasty / Q000009:adverse effects / Q000379:methods*; D023421:Models, Animal; D011897:Random Allocation; D012680:Sensitivity and Specificity; D012756:Sheep; D034561:Sheep, Domestic; D013718:Tensile Strength; D015625:Tissue Expansion Devices; D054457:Tissue Scaffolds; D014945:Wound Healing / Q000502:physiology