title: Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species.
abstract: The white croaker (Argyrosomus argentatus) derived Curvularia sp. IFB-Z10 produces curvulamine as a skeletally unprecedented alkaloid incorporating two undescribed extender units. Curvulamine is more selectively antibacterial than tinidazole and biosynthetically unique in the new extenders formed through a decarboxylative condensation between an oligoketide motif and alanine.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093, China.
authors.forename: Wen Bo
authors.initials: WB
authors.lastname: Han
authors.forename: Yan Hua
authors.initials: YH
authors.lastname: Lu
authors.forename: Ai Hua
authors.initials: AH
authors.lastname: Zhang
authors.forename: Gao Fei
authors.initials: GF
authors.lastname: Zhang
authors.forename: Ya Ning
authors.initials: YN
authors.lastname: Mei
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Lei
authors.forename: Yong Chun
authors.initials: YC
authors.lastname: Song
authors.forename: Seik Weng
authors.initials: SW
authors.lastname: Ng
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000190:Actinomyces / Q000187:drug effects; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001439:Bacteroides / Q000187:drug effects; D026121:Indole Alkaloids; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi; D015394:Molecular Structure; D010462:Peptostreptococcus / Q000187:drug effects; D010473:Perciformes / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects; D014011:Tinidazole / Q000494:pharmacology; D014678:Veillonella / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D026121:Indole Alkaloids; C000599394:curvulamine; D014011:Tinidazole