title: GTF2I-RARA is a novel fusion transcript in a t(7;17) variant of acute promyelocytic leukaemia with clinical resistance to retinoic acid.
authors.affiliation: Department of Haematology/Institute of Molecular Haematology, the Second Xiang-Ya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Zhong
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Le
authors.initials: L
authors.lastname: Xiao
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Bai
authors.forename: Su-Fang
authors.initials: SF
authors.lastname: Liu
authors.forename: Guang-Biao
authors.initials: GB
authors.lastname: Zhou
authors.forename: Guang-Sen
authors.initials: GS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001483:Base Sequence; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D017809:Fatal Outcome; D006801:Humans; D059785:Karyotype; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D050506:Mutant Chimeric Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D018168:Receptors, Retinoic Acid / Q000235:genetics*; D000072482:Retinoic Acid Receptor alpha; D019473:Transcription Factors, TFII / Q000235:genetics*; D014178:Translocation, Genetic; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; C104259:GTF2I protein, human; D050506:Mutant Chimeric Proteins; D009363:Neoplasm Proteins; C000607071:RARA protein, human; D018168:Receptors, Retinoic Acid; D000072482:Retinoic Acid Receptor alpha; D019473:Transcription Factors, TFII; D014212:Tretinoin
keywords: GTF2I; RARA fusion gene; retinoic acid resistance; t(7; 17) translocation; variant acute promyelocytic leukaemia