title: Different effects of fenofibrate on metabolic and cardiovascular risk factors in mixed dyslipidemic women with normal thyroid function and subclinical hypothyroidism.
abstract: OBJECTIVE
  Subclinical hypothyroidism is suggested to increase cardiovascular risk. No previous study compared the effect of any fibrate on plasma levels of lipids and other cardiovascular risk factors in patients with different thyroid function status.
  
  
  METHODS
  The study included three age-, weight- and lipid-matched groups of women with mixed dyslipidemia in different thyroid function status: patients with untreated subclinical hypothyroidism (group 1, n = 18), women with treated hypothyroidism (group 2, n = 15), and subjects without thyroid disorders (group 3, n = 19). Plasma lipids, glucose homeostasis markers, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), homocysteine, and fibrinogen were determined before and after 12 weeks of fenofibrate therapy.
  
  
  RESULTS
  Despite similar plasma lipid levels, mixed dyslipidemic patients with untreated hypothyroidism had decreased insulin sensitivity, as well as higher circulating levels of uric acid, hsCRP, homocysteine, and fibrinogen in comparison with the other groups. The effect of fenofibrate on plasma lipids and, with the exception of homocysteine, on circulating levels of all investigated risk factors was stronger in patients from groups 2 and 3 than in patients from group 1.
  
  
  CONCLUSIONS
  The obtained results indicate that the effect of fenofibrate on plasma lipids and circulating levels of cardiovascular risk factors is partially related to thyroid function. They also suggest that to improve the strength of fibrate action in dyslipidemic patients with subclinical hypothyroidism, they should be administered together with L-thyroxine.
authors.affiliation: Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Krysiak
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gilowski
authors.forename: Witold
authors.initials: W
authors.lastname: Szkrobka
authors.forename: Bogusław
authors.initials: B
authors.lastname: Okopien
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D066126:Cardiotoxicity; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D050171:Dyslipidemias / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D011345:Fenofibrate / Q000627:therapeutic use*; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007037:Hypothyroidism / Q000150:complications* / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D012307:Risk Factors; D013961:Thyroid Gland / Q000503:physiopathology*; D013972:Thyrotropin / Q000097:blood
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D013972:Thyrotropin; D002097:C-Reactive Protein; D011345:Fenofibrate
keywords: Fibrates; Hypothyroidism; Lipid profile; Risk factors