title: Evaluation of oxidative stress parameters and urinary deoxypyridinoline levels in geriatric patients with osteoporosis.
abstract: [Purpose] To evaluate the oxidative stress parameters and urinary deoxypyridinoline levels in geriatric patients with osteoporosis. [Subjects and Methods] Eighty geriatric patients aged over 65 years were recruited. Patients were divided into two groups: Group 1 (n=40) consisted of patients with osteoporosis, and Group 2 (n=40) consisted of patients without osteoporosis. Bone mineral density measurements were performed for all patients using DEXA. Oxidative stress parameters were analyzed in blood samples, and deoxypyridinoline levels were analyzed in 24-hour urinary samples. [Results] Compared to Group 2, the total antioxidant status and oxidative stress index levels of Group 1 were not significantly different; however, total oxidant status and 24-hour urinary deoxypyridinoline levels were significantly higher. Pearson correlation coefficients indicated that OSI and urinary deoxypyridinoline levels were not correlated with any biochemical parameters. ROC-curve analysis revealed that urinary deoxypyridinoline levels over 30.80 mg/ml predicted osteoporosis with 67% sensitivity and 68% specificity (area under the curve = 0.734; %95 CI: 0.624-0.844). [Conclusion] Our results indicate that oxidative stress would play a role in the pathogenesis of osteoporosis, and that urinary deoxypyridinoline levels may be a useful screening test for osteoporosis.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Harran University, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Demir
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Harran University, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Ulas
authors.affiliation: Department of Physical Therapy and Rehabilitation, Harran University School of Medicine, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tutoglu
authors.affiliation: Department of Physical Therapy and Rehabilitation, Harran University School of Medicine, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Boyaci
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Harran University, Turkey.
authors.forename: Emel Yigit
authors.initials: EY
authors.lastname: Karakas
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Turkey.
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Ustunel
authors.affiliation: Department of Biochemistry, Harran University School of Medicine, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Bilinc
authors.affiliation: Department of Pulmonary Diseases, Harran University School of Medicine, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gencer
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Harran University, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Buyukhatipoglu
keywords: Deoxypyridinoline; Osteoporosis; Oxidative stress index