title: Mission CaMKIIγ: shuttle calmodulin from membrane to nucleus.
abstract: Neuronal plasticity depends on plasma membrane Ca(2+) influx, resulting in activity-dependent gene transcription. Calmodulin (CaM) activated by Ca(2+) initiates the nuclear events, but how CaM makes its way to the nucleus has remained elusive. Ma et al. now show that CaMKIIγ transports CaM from cell surface Ca(2+) channels to the nucleus.
authors.affiliation: Department of Pharmacology, University of California, Davis, Davis, CA 95615, USA.
authors.forename: Zulfiqar A
authors.initials: ZA
authors.lastname: Malik
authors.affiliation: Department of Pharmacology, University of California, Davis, Davis, CA 95615, USA.
authors.forename: Ivar S
authors.initials: IS
authors.lastname: Stein
authors.affiliation: Department of Pharmacology, University of California, Davis, Davis, CA 95615, USA.
authors.forename: Manuel F
authors.initials: MF
authors.lastname: Navedo
authors.affiliation: Department of Pharmacology, University of California, Davis, Davis, CA 95615, USA. Electronic address: jwhell@ucdavis.edu.
authors.forename: Johannes W
authors.initials: JW
authors.lastname: Hell
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2