title: Distinct iEEG activity patterns in temporal-limbic and prefrontal sites induced by emotional intentionality.
abstract: Our emotions tend to be directed towards someone or something. Such emotional intentionality calls for the integration between two streams of information; abstract hedonic value and its associated concrete content. In a previous functional magnetic resonance imaging (fMRI) study we found that the combination of these two streams, as modeled by short emotional music excerpts and neutral film clips, was associated with synergistic activation in both temporal-limbic (TL) and ventral-lateral PFC (vLPFC) regions. This additive effect implies the integration of domain-specific 'affective' and 'cognitive' processes. Yet, the low temporal resolution of the fMRI limits the characterization of such cross-domain integration. To this end, we complemented the fMRI data with intracranial electroencephalogram (iEEG) recordings from twelve patients with intractable epilepsy. As expected, the additive fMRI activation in the amygdala and vLPFC was associated with distinct spatio-temporal iEEG patterns among electrodes situated within the vicinity of the fMRI activation foci. On the one hand, TL channels exhibited a transient (0-500 msec) increase in gamma power (61-69 Hz), possibly reflecting initial relevance detection or hedonic value tagging. On the other hand, vLPFC channels showed sustained (1-12 sec) suppression of low frequency power (2.3-24 Hz), possibly mediating changes in gating, enabling an on-going readiness for content-based processing of emotionally tagged signals. Moreover, an additive effect in delta-gamma phase-amplitude coupling (PAC) was found among the TL channels, possibly reflecting the integration between distinct domain specific processes. Together, this study provides a multi-faceted neurophysiological signature for computations that possibly underlie emotional intentionality in humans.
authors.affiliation: Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel; School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Neomi
authors.initials: N
authors.lastname: Singer
authors.affiliation: Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Ilana
authors.initials: I
authors.lastname: Podlipsky
authors.affiliation: Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands; Department of Medicine and Surgery, University of Salerno, Baronissi (SA), Italy.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Esposito
authors.affiliation: Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Hadas
authors.initials: H
authors.lastname: Okon-Singer
authors.affiliation: Functional Neurosurgery Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Fani
authors.initials: F
authors.lastname: Andelman
authors.affiliation: Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Epilepsy Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Kipervasser
authors.affiliation: Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Epilepsy Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: Miri Y
authors.initials: MY
authors.lastname: Neufeld
authors.affiliation: Department of Cognitive Neuroscience, Maastricht University, Maastricht, The Netherlands.
authors.forename: Rainer
authors.initials: R
authors.lastname: Goebel
authors.affiliation: Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Functional Neurosurgery Unit, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Division of Neurosurgery, David Geffen School of Medicine and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA.
authors.forename: Itzhak
authors.initials: I
authors.lastname: Fried
authors.affiliation: Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel; School of Psychological Sciences, Tel-Aviv University, Tel-Aviv, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel. Electronic address: talma@tasmc.health.gov.il.
authors.forename: Talma
authors.initials: T
authors.lastname: Hendler
mesh_terms: D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008032:Limbic System / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D017397:Prefrontal Cortex / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology*
keywords: Emotional dynamics; Gamma power; High- and low frequency oscillations; Phase-amplitude-coupling; iEEG and fMRI