title: Point-of-care diagnostics, a major opportunity for change in traditional diagnostic approaches: potential and limitations.
abstract: 'Point-of-care' (POC) diagnostics are a powerful emerging healthcare approach. They can rapidly provide statistically significant results, are simple to use, do not require specialized equipment and are cost-effective. For these reasons, they have the potential to play a major role in revolutionizing the diagnosis, initiation and monitoring of treatment of major global diseases. This review focuses on antibody-based POC devices that target four major global diseases: cardiovascular diseases, prostate cancer, HIV infection and tuberculosis. The key statistics and pathology of each disease is described in detail, followed by an in-depth discussion on emerging POC devices that target each disease, highlighting their potential and limitations.
authors.affiliation: School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Co. Dublin, Ireland.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: McPartlin
authors.forename: Richard J
authors.initials: RJ
authors.lastname: O'Kennedy
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods / Q000592:standards; D002318:Cardiovascular Diseases / Q000175:diagnosis; D019937:Diagnostic Techniques and Procedures; D015658:HIV Infections / Q000175:diagnosis; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis; D019095:Point-of-Care Systems / Q000592:standards; D014376:Tuberculosis / Q000175:diagnosis
keywords: HIV; POC; TB; acute myocardial infarction; antibody; biosensor; cardiovascular disease; mHealth; prostate cancer