title: Are the risk factors associated with Staphylococcus aureus nasal carriage in patients the same than in healthy volunteers? Data from a cohort of patients scheduled for orthopedic material implantation.
abstract: The risk factors for Staphylococcus aureus nasal carriage have been mainly defined in healthy volunteers. Using data from a large multicenter prospective clinical cohort of orthopedic surgical patients we showed that obesity (BMI > 30) and younger age were independent risk factors for persistent carriage. In the absence of recommendations for S aureus decolonization in orthopedic surgery, this study suggests that at least obese patients should be targeted to prevent surgical site infections.
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Infectious Diseases Department, University Hospital of Saint-Etienne, Saint-Etienne, France. Electronic address: e.botelhonevers@gmail.com.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Botelho-Nevers
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Laboratory of Bacteriology Virology Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Berthelot
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Laboratory of Bacteriology Virology Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Paul Oswald
authors.initials: PO
authors.lastname: Verhoeven
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Laboratory of Bacteriology Virology Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Grattard
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Infectious Diseases Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Celine
authors.initials: C
authors.lastname: Cazorla
authors.affiliation: Orthopedic Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Farizon
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Laboratory of Bacteriology Virology Hygiene, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pozzetto
authors.affiliation: GIMAP EA 3064 (Immunity of mucosa and pathogen agents group), University of Lyon, Saint-Etienne, France; Infectious Diseases Department, University Hospital of Saint-Etienne, Saint-Etienne, France.
authors.forename: Frederic
authors.initials: F
authors.lastname: Lucht
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission*; D018562:Disease Transmission, Infectious; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D010361:Patients; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D014946:Wound Infection / Q000453:epidemiology* / Q000382:microbiology
keywords: Carriage; Colonization; Nosocomial infection; S aureus; Surgical site infection