title: Use of novel oral anticoagulant agents in atrial fibrillation: current evidence and future perspective.
abstract: The increasing availability of novel oral anticoagulants (NOAC) for the prevention of stroke and systemic embolism in patients with nonvalvular atrial fibrillation (AF) offers alternatives for patients currently prescribed warfarin. This article provides a brief overview on the mechanism and clinical use of these drugs as well as a review of the pivotal clinical trials providing the basis for each agent's safety and efficacy. While these agents are currently Food and Drug Administration (FDA) approved for anticoagulation of patients with nonvalvular AF, additional studies continually emerge offering further insight into the application of these agents in other areas.
authors.affiliation: 1 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA ; 2 Division of Cardiovascular Medicine, Department of Internal Medicine, University Hospitals Case Medical Center and Harrington Heart and Vascular Institute, Cleveland, OH, USA.
authors.forename: Shivanshu
authors.initials: S
authors.lastname: Madan
authors.affiliation: 1 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA ; 2 Division of Cardiovascular Medicine, Department of Internal Medicine, University Hospitals Case Medical Center and Harrington Heart and Vascular Institute, Cleveland, OH, USA.
authors.forename: Shenil
authors.initials: S
authors.lastname: Shah
authors.affiliation: 1 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA ; 2 Division of Cardiovascular Medicine, Department of Internal Medicine, University Hospitals Case Medical Center and Harrington Heart and Vascular Institute, Cleveland, OH, USA.
authors.forename: Sasan
authors.initials: S
authors.lastname: Partovi
authors.affiliation: 1 Department of Internal Medicine, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA ; 2 Division of Cardiovascular Medicine, Department of Internal Medicine, University Hospitals Case Medical Center and Harrington Heart and Vascular Institute, Cleveland, OH, USA.
authors.forename: Sahil A
authors.initials: SA
authors.lastname: Parikh
keywords: Dabigatran; anticoagulation; apixaban; nonvalvular atrial fibrillation (AF); rivaroxaban; warfarin