title: Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology.
abstract: We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5 years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.
authors.affiliation: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
authors.forename: Susanna
authors.initials: S
authors.lastname: Ranta
authors.forename: Ruta
authors.initials: R
authors.lastname: Tuckuviene
authors.forename: Anne
authors.initials: A
authors.lastname: Mäkipernaa
authors.forename: Birgitte K
authors.initials: BK
authors.lastname: Albertsen
authors.forename: Tony
authors.initials: T
authors.lastname: Frisk
authors.forename: Ulf
authors.initials: U
authors.lastname: Tedgård
authors.forename: Ólafur G
authors.initials: ÓG
authors.lastname: Jónsson
authors.forename: Kaie
authors.initials: K
authors.lastname: Pruunsild
authors.forename: Nadine
authors.initials: N
authors.lastname: Gretenkort Andersson
authors.forename: Maria
authors.initials: M
authors.lastname: Winther Gunnes
authors.forename: Sonata
authors.initials: S
authors.lastname: Saulyte Trakymiene
authors.forename: Thomas
authors.initials: T
authors.lastname: Frandsen
authors.forename: Mats
authors.initials: M
authors.lastname: Heyman
authors.forename: Ellen
authors.initials: E
authors.lastname: Ruud
authors.forename: Jon
authors.initials: J
authors.lastname: Helgestad
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects; D001454:Baltic States / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D060830:Consolidation Chemotherapy; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D011446:Prospective Studies; D012307:Risk Factors; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D001215:Asparaginase
keywords: acute leukaemia; cerebral sinovenous thrombosis; paediatric