title: Organophosphate pesticide exposure in school-aged children living in rice and aquacultural farming regions of Thailand.
abstract: Organophosphate pesticides (OPs) are widely used in agricultural sectors in Thailand. Previous studies have documented that children residing in agricultural areas have higher exposure to OPs than children living in other residential areas. The objective of this study was to quantify urinary biomarkers of OP exposure and determine the environmental conditions and activities that predict their levels among children living in Central Thailand farming regions. In October 2011, 53 6-8-year-old participants were recruited from Pathum Thani Province, Thailand. Twenty-four lived in rice farming communities at Khlong Luang District where OPs are the pesticides used frequently. Twenty-nine participants, living in aquacultural farming communities at Lum Luk Ka District where OPs are not used, were recruited to serve as controls for pathways of exposure (e.g., residential, dietary) other than occupational/paraoccupational exposures encountered in rice farming. Household environments and participants' activities were assessed using a parental structured interview. Urine samples (first morning voids) were collected from participants for OP urinary metabolite (i.e., dialkylphosphates [DAPs] and 3,5,6-trichloro-2-pyridinol [TCPy]) measurements. The levels of most urinary OP metabolites were significantly higher in participants who lived in a rice farming community than those who lived in an aquacultural farming community (P < .05). The results from linear regression analysis revealed that the frequency of OP application on rice farms (∑DAP: P = .001; TCPy: P = .001) and living in a rice farming community (∑DAP: P = .009; TCPy: P < .001) were significant predictors of urinary DAP metabolite levels in participants. Increasing TCPy levels were significantly related to proximity to rice farm (P = .03), being with parent while working on a farm (P = .02), playing on a farm (P = .03), and the presence of observable dirt accumulated on the child's body (P = .02). In conclusion, OP metabolite levels among children who live in rice farming communities were strongly influenced by farming activity, household environments, and child behaviors, suggesting that these are the primary pathways in which children living in these agricultural communities in Thailand were exposed to OPs.
authors.affiliation: a College of Public Health Sciences, Chulalongkorn University , Bangkok , Thailand.
authors.forename: Juthasiri
authors.initials: J
authors.lastname: Rohitrattana
authors.forename: Wattasit
authors.initials: W
authors.lastname: Siriwong
authors.forename: Tanasorn
authors.initials: T
authors.lastname: Tunsaringkarn
authors.forename: Parinya
authors.initials: P
authors.lastname: Panuwet
authors.forename: P Barry
authors.initials: PB
authors.lastname: Ryan
authors.forename: Dana Boyd
authors.initials: DB
authors.lastname: Barr
authors.forename: Mark G
authors.initials: MG
authors.lastname: Robson
authors.forename: Nancy
authors.initials: N
authors.lastname: Fiedler
mesh_terms: D000383:Agriculture; D002648:Child; D004390:Chlorpyrifos / Q000652:urine; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects / Q000032:analysis; D009943:Organophosphorus Compounds / Q000633:toxicity* / Q000652:urine; D012275:Oryza; D010575:Pesticides / Q000378:metabolism / Q000633:toxicity / Q000652:urine*; D012423:Rural Health; D012424:Rural Population; D013785:Thailand
chemical_list: D009943:Organophosphorus Compounds; D010575:Pesticides; D004390:Chlorpyrifos
keywords: 3,5,6-trichloro-2-pyridinol (TCPy); Activity; children; dialkylphosphates (DAPs); environment; organophosphate pesticides (OPs)