title: Cardioprotective effect of ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy in experimental animals.
abstract: OBJECTIVE
  The objective of this study was to evaluate the cardioprotective effect of herbal bioactive compound ammonium glycyrrhizinate against doxorubicin-induced cardiomyopathy, in experimental animals.
  
  
  METHODS
  Ammonium glycyrrhizinate (50, 100, 200 mg/kg, p.o.) was administered for four weeks in albino rats. Cardiomyopathy was induced with a dose of 2.5 mg/kg i.p. of doxorubicin on 1(th), 7(th), 14(th), 21(th), 28(th) day in the experimental animals. At the end of the experiment, on 29(th) day, serum and heart tissues were collected and hemodynamic, biochemical and histopathological studies were carried out.
  
  
  RESULTS
  Administration of doxorubicin in normal rats showed significant (P < 0.001) changes in body weight, feed intake, urine output, hemodynamic parameters like (blood pressure, heart rate, cardiac output) and in lipid profile (cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, very low density lipoprotein) indicating cardiomyopathy symptoms. Animals treated with ammonium glycyrrhizinate significantly (P < 0.05) decreased triglyceride, cholesterol, low density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels. Moreover, high density lipoprotein (HDL) levels increased in rats treated with ammonium glycyrrhizinate as compared with the normal group.
  
  
  CONCLUSIONS
  Ammonium glycyrrhizinate is effective in controlling serum lipid profile and cardiac complications in experimentally induced cardiomyopathy in animals.
authors.affiliation: Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
authors.forename: Munish
authors.initials: M
authors.lastname: Garg
authors.affiliation: Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
authors.forename: Tinku
authors.initials: T
authors.lastname: Singhal
authors.affiliation: Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.
authors.forename: Hitender
authors.initials: H
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D009202:Cardiomyopathies / Q000139:chemically induced / Q000517:prevention & control*; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D019695:Glycyrrhizic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000903:Antibiotics, Antineoplastic; D002316:Cardiotonic Agents; D008055:Lipids; D019695:Glycyrrhizic Acid; D004317:Doxorubicin
keywords: Ammonium glycyrrhizinate; cardiac failure; cardiomyopathy; doxorubicin