title: Hyperuricemia and acute kidney injury secondary to spontaneous tumor lysis syndrome in low risk myelodysplastic syndrome.
abstract: BACKGROUND
  This is a rare instance of acute kidney injury caused by hyperuricemia due to spontaneous tumor lysis syndrome and also the first case of spontaneous tumor lysis syndrome reported in association with myelodysplastic syndrome.
  
  
  METHODS
  A 53-year-old man presented with abrupt oliguria. Laboratory findings on admission included hyperuricemia, hyperphosphatemia, hypocalcemia, metabolic acidosis and rapidly rising serum creatinine, which were consistent with acute tumor lysis syndrome in the absence of precipitating chemotherapy or radiotherapy. After hemodialysis and oral uric acid lowering therapy, serum uric acid levels returned to normal range and renal function rapidly recovered. The patient was diagnosed as myelodysplastic syndrome eleven months later.
  
  
  CONCLUSIONS
  Occult malignancy including solid tumors and hematological malignancies should be carefully evaluated in the case of unexplainable acute kidney injury with hyperuricemia. Aggressive investigations should be thoroughly considered and repeated in this population.
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Feng
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.affiliation: Division of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu 610072, China. scwangli62@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000753:Anemia, Refractory / Q000150:complications* / Q000175:diagnosis; D017081:Cholecystectomy, Laparoscopic; D006801:Humans; D033461:Hyperuricemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009846:Oliguria / Q000209:etiology; D011183:Postoperative Complications / Q000175:diagnosis; D012306:Risk; D013997:Time Factors; D015275:Tumor Lysis Syndrome / Q000150:complications*