title: Protective effect ofAsarumextract in rats with adjuvant arthritis.
abstract: The aim of the present study was to investigate the protective effect ofAsarumextract on rats with adjuvant arthritis (AA) and to determine the underlying mechanism. An AA model was established by injecting Freund's complete adjuvant into the rats. The degree of toe swelling, arthritis index, spleen index, and the expression levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 were measured. In addition, the underlying molecular mechanism was investigated using murine macrophage-derived RAW 264.7 cells.Asarumextract was found to significantly reduce the severity of arthritis by decreasing hind paw swelling, the arthritis index, the spleen index, and TNF-α, IL-1β and IL-6 expression levels in plasma.In vitro,Asarumextract inhibited the nuclear factor (NF)-κB and mitogen-activated protein kinase (MAPK) signaling pathways. These results indicate thatAsarumextract may be a therapeutic agent for AA and may exert an anti-inflammatory effect by mediating the NF-κB and MAPK signaling pathways.
authors.affiliation: Department of Orthopedics, Shandong Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China.
authors.forename: Wenqiang
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, No. 2 Hospital Affiliated to Shandong University, Jinan, Shandong 250033, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Shandong Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Qilu Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Nie
keywords: adjuvant arthritis; rheumatoid arthritis