title: Dedifferentiated giant-cell tumor of bone with an undifferentiated round cell mesenchymal component.
abstract: The dedifferentiated giant-cell tumor of the bone is a very rare variant of the giant-cell tumor (GCT). We report the clinical, radiographic and histological findings of a dedifferentiated GCT in which the dedifferentiated component consisted of small round cells. We also comment on previously reported cases of dedifferentiated GCT, discuss the clinical implications of this dual histology, and analyze the information published about the coexistence of similar genetic abnormalities in GCT and small round cell tumors of the bone.
authors.affiliation: Department of Pathology, National Institute of Rehabilitation , Mexico City, Mexico.
authors.forename: Eréndira G
authors.initials: EG
authors.lastname: Estrada-Villaseñor
authors.affiliation: Magnetic Resonance Service, National Institute of Rehabilitation , Mexico City, Mexico.
authors.forename: Socorro
authors.initials: S
authors.lastname: Cortés-González
authors.affiliation: Bone Tumors Service, National Institute of Rehabilitation , Mexico City, Mexico.
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Linares-González
authors.affiliation: Bone Tumors Service, National Institute of Rehabilitation , Mexico City, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: González-Guzmán
authors.affiliation: Bone Tumors Service, National Institute of Rehabilitation , Mexico City, Mexico.
authors.forename: Genaro
authors.initials: G
authors.lastname: Rico-Martínez
keywords: bone tumor; dedifferentiated; giant-cell tumor