title: Prognostic significance of pretreatment plasma fibrinogen and platelet levels in patients with early-stage cervical cancer.
abstract: BACKGROUND
  Hyperfibrinogenaemia and thrombocytosis, which usually occur in cancer patients, have been shown to contribute to cancer cell growth, progression, and metastasis. The aims of the present study were to assess the prognostic significance of pretreatment plasma fibrinogen and platelet levels in early-stage cervical cancer patients.
  
  
  METHODS
  The present study was a retrospective analysis of 220 cervical cancer patients with stage I-IIA disease. The pretreatment plasma fibrinogen and platelet levels were investigated along with clinicopathological findings and survival data.
  
  
  RESULTS
  The incidences of hyperfibrinogenaemia and thrombocytosis were 11.8 and 25.5%, respectively. Elevated fibrinogen levels were associated with advanced tumour stage, older age, large tumour size, deep stromal invasion, and tumour recurrence, whereas higher platelet levels correlated significantly with advanced tumour stage, large tumour size, and tumour recurrence. Kaplan-Meier analysis showed that hyperfibrinogenaemia and thrombocytosis were significantly associated with shorter disease-free and overall survival. Furthermore, patients with hyperfibrinogenaemia and thrombocytosis may suffer from a higher risk of recurrence. Multivariate survival analyses showed that fibrinogen levels, but not platelet levels, were an independent prognostic factor for poor survival in early-stage patients.
  
  
  CONCLUSIONS
  Hyperfibrinogenaemia and thrombocytosis may be valuable biomarkers for predicting recurrence in patients with early-stage cervical cancer.
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
authors.forename: Kelei
authors.initials: K
authors.lastname: Zhao
authors.forename: Huan
authors.initials: H
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Qin
authors.forename: Wenjun
authors.initials: W
authors.lastname: Liao
authors.forename: Weijiang
authors.initials: W
authors.lastname: Liang
mesh_terms: D000328:Adult; D000367:Age Factors; D018572:Disease-Free Survival; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D053208:Kaplan-Meier Estimate; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood; D009367:Neoplasm Staging; D010976:Platelet Count; D057234:Preoperative Period; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D013922:Thrombocytosis / Q000150:complications; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery
chemical_list: D005340:Fibrinogen