title: Investigation of single-drug-encapsulating liposomes using the nano-impact method.
abstract: Encapsulating liposomes are widely used for controlled drug delivery. We report the use of nano-impact experiments for the electrochemical attomolar quantification of the liposome load, uniquely at the single liposome level, using vitamin C encapsulated liposomes as a model. The size of the liposomes and their picomolar concentration are also determined in biological buffer in real time.
authors.affiliation: Department of Chemistry, Physical & Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QZ (UK).
authors.forename: Wei
authors.initials: W
authors.lastname: Cheng
authors.forename: Richard G
authors.initials: RG
authors.lastname: Compton
mesh_terms: D004337:Drug Carriers; D008081:Liposomes; D036103:Nanotechnology
chemical_list: D004337:Drug Carriers; D008081:Liposomes
keywords: drug delivery; electrochemistry; liposomes; nano-impact method; nanoparticles