title: GroopM: an automated tool for the recovery of population genomes from related metagenomes.
abstract: Metagenomic binning methods that leverage differential population abundances in microbial communities (differential coverage) are emerging as a complementary approach to conventional composition-based binning. Here we introduce GroopM, an automated binning tool that primarily uses differential coverage to obtain high fidelity population genomes from related metagenomes. We demonstrate the effectiveness of GroopM using synthetic and real-world metagenomes, and show that GroopM produces results comparable with more time consuming, labor-intensive methods.
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Imelfort
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Donovan
authors.initials: D
authors.lastname: Parks
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Woodcroft
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Paul
authors.initials: P
authors.lastname: Dennis
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Philip
authors.initials: P
authors.lastname: Hugenholtz
authors.affiliation: Australian Center for Ecogenomics (ACE), School of Chemistry and Molecular Biosciences, The University of Queensland , St Lucia, QLD , Australia ; Advanced Water Management Center (AWMC), The University of Queensland , St Lucia, QLD , Australia.
authors.forename: Gene W
authors.initials: GW
authors.lastname: Tyson
keywords: Bioinformatics; Metagenomics; Microbial ecology; Population genome binning