title: Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain.
abstract: Subjects with Alzheimer's disease (AD) have elevated brain levels of the selenium transporter selenoprotein P (Sepp1). We investigated if this elevation results from increased release of Sepp1 from the choroid plexus (CP). Sepp1 is significantly increased in CP from AD brains in comparison to non-AD brains. Sepp1 localizes to the trans-Golgi network within CP epithelia, where it is processed for secretion. The cerebrospinal fluid from AD subjects also contains increased levels Sepp1 in comparison to non-AD subjects. These findings suggest that AD pathology induces increased levels of Sepp1 within CP epithelia for release into the cerebrospinal fluid to ultimately increase brain selenium.
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Rachel H L H
authors.initials: RH
authors.lastname: Rueli
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Arlene C
authors.initials: AC
authors.lastname: Parubrub
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Andrea S T
authors.initials: AS
authors.lastname: Dewing
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Ann C
authors.initials: AC
authors.lastname: Hashimoto
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Miyoko T
authors.initials: MT
authors.lastname: Bellinger
authors.affiliation: Molecular Pharmacology and Physiology, University of South Florida, Johnnie B. Byrd, Sr. Alzheimer's Center & Research Institute, Tampa, FL, USA.
authors.forename: Edwin J
authors.initials: EJ
authors.lastname: Weeber
authors.affiliation: Pathology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Jane H
authors.initials: JH
authors.lastname: Uyehara-Lock
authors.affiliation: Pacific Health Research and Education Institute, Honolulu, HI, USA.
authors.forename: Lon R
authors.initials: LR
authors.lastname: White
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Marla J
authors.initials: MJ
authors.lastname: Berry
authors.affiliation: Cell and Molecular Biology Department, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Bellinger
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism*; D002831:Choroid Plexus / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D051149:Selenoprotein P / Q000378:metabolism*
chemical_list: D051149:Selenoprotein P
keywords: Alzheimer's disease; Sepp1; cerebrospinal fluid; choroid plexus; selenium; selenoprotein P; selenoproteins