title: Early life seizures: evidence for chronic deficits linked to autism and intellectual disability across species and models.
abstract: Recent work in Exp Neurol by Lugo et al. (2014b) demonstrated chronic alterations in sociability, learning and memory following multiple early life seizures (ELS) in a mouse model. This work adds to the growing body of evidence supporting the detrimental nature of ELS on the developing brain to contribute to aspects of an autistic phenotype with intellectual disability. Review of the face validity of behavioral testing and the construct validity of the models used informs the predictive ability and thus the utility of these models to translate underlying molecular and cellular mechanisms into future human studies.
authors.affiliation: Department of Pediatrics, University of Colorado, School of Medicine, USA.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Bernard
authors.affiliation: Department of Pediatrics, University of Colorado, School of Medicine, USA; Neuroscience Graduate Program, University of Colorado, School of Medicine, USA; Department of Neurology, University of Colorado, School of Medicine, USA; Department of Pharmacology, University of Colorado, School of Medicine, USA; Department of Otolaryngology, University of Colorado, School of Medicine, USA. Electronic address: tim.benke@ucdenver.edu.
authors.forename: Tim A
authors.initials: TA
authors.lastname: Benke
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000209:etiology*; D003072:Cognition Disorders / Q000209:etiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology*; D012640:Seizures / Q000150:complications*; D012919:Social Behavior
keywords: Animal model; Anxiety; Autism; Communication; Early life seizure; Intellectual disability; Learning; Memory; Social