title: Implantable photonic devices for improved medical treatments.
abstract: An evolving area of biomedical research is related to the creation of implantable units that provide various possibilities for imaging, measurement, and the monitoring of a wide range of diseases and intrabody phototherapy. The units can be autonomic or built-in in some kind of clinically applicable implants. Because of specific working conditions in the live body, such implants must have a number of features requiring further development. This topic can cause wide interest among developers of optical, mechanical, and electronic solutions in biomedicine. We introduce preliminary clinical trials obtained with an implantable pill and devices that we have developed. The pill and devices are capable of applying in-body phototherapy, low-level laser therapy, blue light (450 nm) for sterilization, and controlled injection of chemicals. The pill is also capable of communicating with an external control box, including the transmission of images from inside the patient’s body. In this work, our pill was utilized for illumination of the sinus-carotid zone in dog and red light influence on arterial pressure and heart rate was demonstrated. Intrabody liver tissue laser ablation and nanoparticle-assisted laser ablation was investigated. Sterilization effect of intrabody blue light illumination was applied during a maxillofacial phlegmon treatment.
authors.affiliation: Bar-Ilan University, Faculty of Engineering, Ramat-Gan 5290002, Israel.
authors.forename: Victor
authors.initials: V
authors.lastname: Sheinman
authors.affiliation: Bar-Ilan University, Faculty of Engineering, Ramat-Gan 5290002, Israel.
authors.forename: Arkady
authors.initials: A
authors.lastname: Rudnitsky
authors.affiliation: Institute of Medical Problems, Southern Branch of National Academy of Sciences of the Kyrgyz Republic, 723506 Osh, Kyrgyz Republic.
authors.forename: Rakhmanbek
authors.initials: R
authors.lastname: Toichuev
authors.affiliation: Regional Clinical Hospital of Osh, 723504 Osh, Kyrgyz Republic.
authors.forename: Abdyrakhman
authors.initials: A
authors.lastname: Eshiev
authors.affiliation: Regional Clinical Hospital of Osh, 723504 Osh, Kyrgyz Republic.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Abdullaeva
authors.affiliation: Regional Clinical Hospital of Osh, 723504 Osh, Kyrgyz Republic.
authors.forename: Talantbek
authors.initials: T
authors.lastname: Egemkulov
authors.affiliation: Bar-Ilan University, Faculty of Engineering, Ramat-Gan 5290002, Israel.
authors.forename: Zeev
authors.initials: Z
authors.lastname: Zalevsky
mesh_terms: D000818:Animals; D002481:Cellulitis / Q000601:surgery; D004285:Dogs; D004724:Endoscopy / Q000295:instrumentation; D008099:Liver / Q000601:surgery; D055095:Optics and Photonics / Q000295:instrumentation*; D019647:Oral Surgical Procedures / Q000295:instrumentation; D010789:Phototherapy / Q000295:instrumentation*; D019736:Prostheses and Implants; D011817:Rabbits; D013242:Sterilization / Q000295:instrumentation; D014945:Wound Healing