title: Dermoscopy, reflectance confocal microscopy and histopathology of a melanoma in situ from an individual homozygous for GSTP1*105Val/MC1R*92Met.
abstract: Glutathione S-transferase 1 is an enzyme involved in the detoxification of reactive oxygen species, and the rs1695*Val polymorphism has been proposed as a melanoma-associated variant with significant effect. We report a case of malignant melanoma in an individual homozygous for the rs1695*Val variant and discuss the non-invasive and histopathological tools used in diagnosis.
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.
authors.forename: Parastoo
authors.initials: P
authors.lastname: Banan
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.
authors.forename: Katie J
authors.initials: KJ
authors.lastname: Lee
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.
authors.forename: Phil
authors.initials: P
authors.lastname: McClenahan
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.|Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Kasturee
authors.initials: K
authors.lastname: Jagirdar
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.|Melanogenix Group, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Sturm
authors.affiliation: Dermatology Research Centre, School of Medicine, Translational Research Institute.
authors.forename: H Peter
authors.initials: HP
authors.lastname: Soyer
mesh_terms: D000368:Aged; D046169:Dermoscopy; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D018613:Microscopy, Confocal; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D012878:Skin Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*
chemical_list: C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi
keywords: GSTP1; RCM; dermoscopy; melanoma; regressive melanoma in situ; skin microbiopsy