title: [Biochemical parameters of blood and morpho-functional state of the liver of experimental animals by the actions of lead sulfide nanoparticles in different time study].
abstract: Biochemical studies revealed that alanine aminotransferase levels changing first during short action (30 injections) of lead sulfide nanoparticles of size 10 and 30 nm, and the ionic form of a 400 nm lead while the growth of both enzymes (aspartate aminotransferase and alanine aminotransferase) activity during long-term exposure (60 injections) is the same intensity. It it confirmed by the value of de Ritis coefficient, which is statistically the same as control. Morphological studies also confirm these data--degenerative changes of hepatocytes, reactive changes of the stroma and vascular responses were detected. It is shown that the severity of metabolic and morphological damages in the liver increased with prolonging the duration of lead nanoparticles intake.
authors.forename: S T
authors.initials: ST
authors.lastname: Omel'chuk
authors.forename: V D
authors.initials: VD
authors.lastname: Aleksiĭchuk
authors.forename: L M
authors.initials: LM
authors.lastname: Sokurenko
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D022781:Hepatocytes / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D053758:Nanoparticles / Q000633:toxicity*; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides / Q000633:toxicity*
chemical_list: D013440:Sulfides; C018391:lead sulfide; D007854:Lead; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase