title: De novo reciprocal translocation t(5;11)(q22;p15) associated with hydrops fetalis (reciprocal translocation and hydrops fetalis).
abstract: OBJECTIVE
  This is a case of a prenatally diagnosed non-immune hydrops fetalis (NIHF) associated with translocation t(5;11)(q22;p15). An association between NIHF and this translocation has not been reported previously.
  
  
  METHODS
  The patient was referred to the perinatology clinic with hydrops fetalis diagnosis at 23 weeks' gestation. We noted that the fetus had bilateral pleural effusion, ascites, widespread subcutaneous edema, membranous ventricular septal defect, hypoplastic fifth finger middle phalanx, clinodactyly, single umbilical artery. We performed cordocentesis. Chromosomal analysis on blood showed a balanced translocation between the long arm of chromosome 5 and the short arm of chromosome 11 with karyotype of 46,XX,t(5;11)(q22;p15).
  
  
  CONCLUSIONS
  We present prenatal diagnosis of a de novo translocation (5;11) in a hydropic fetus with ultrason abnormalities. In our case, karyotype analysis of the fetus, mother and father provided evidence of a de novo translocation, that might explain the NIHF.
authors.affiliation: Perinatology Division, Obstetrics and Gynecology Department, Celal Bayar University School of Medicine , Manisa , Turkey.
authors.forename: Halil Gursoy
authors.initials: HG
authors.lastname: Pala
authors.forename: Burcu
authors.initials: B
authors.lastname: Artunc-Ulkumen
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Uyar
authors.forename: Filiz
authors.initials: F
authors.lastname: Bal
authors.forename: Yesim Bulbul
authors.initials: YB
authors.lastname: Baytur
authors.forename: Faik Mumtaz
authors.initials: FM
authors.lastname: Koyuncu
mesh_terms: D000328:Adult; D001201:Ascites / Q000235:genetics; D002869:Chromosome Aberrations; D002880:Chromosomes, Human, Pair 11 / Q000648:ultrastructure; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure; D017218:Cordocentesis; D005260:Female; D005313:Fetal Death; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D010996:Pleural Effusion / Q000235:genetics; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic
keywords: hydrops fetalis; prenatal diagnose; reciprocal translocation; ultrasonography