title: Functional optoacoustic human angiography with handheld video rate three dimensional scanner.
abstract: Optoacoustic imaging provides a unique combination of high optical contrast and excellent spatial resolution, making it ideal for simultaneous imaging of tissue anatomy as well as functional and molecular contrast in deep optically opaque tissues. We report on development of a portable clinical system for three-dimensional optoacoustic visualization of deep human tissues at video rate. Studies in human volunteers have demonstrated powerful performance in delivering high resolution volumetric multispectral optoacoustic tomography (vMSOT) images of tissue morphology and function, such as blood oxygenation parameters, in real time. Whilst most imaging modalities currently in clinical use are not able to deliver volumetric data with comparable time resolution, the presented imaging approach holds promise to attain new diagnostic and treatment monitoring value for multiple indications, such as cardiovascular and peripheral vascular disease, disorders related to the lymphatic system, breast lesions, arthritis and inflammation.
authors.affiliation: Institute for Biological and Medical Imaging (IBMI), Helmholtz Center Munich, Ingolstädter Landstraβe 1, 85764 Neuherberg, Germany ; Faculty of Medicine, Technical University of Munich, Ismaninger Straβe 22, 81675 Munich, Germany.
authors.forename: Xosé Luís
authors.initials: XL
authors.lastname: Deán-Ben
authors.affiliation: Institute for Biological and Medical Imaging (IBMI), Helmholtz Center Munich, Ingolstädter Landstraβe 1, 85764 Neuherberg, Germany ; Faculty of Medicine, Technical University of Munich, Ismaninger Straβe 22, 81675 Munich, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Razansky
keywords: Cardiovascular diagnostics; Functional and molecular imaging; Optoacoustic imaging