title: Treating umbilical granuloma with topical clobetasol propionate cream at home is as effective as treating it with topical silver nitrate in the clinic.
abstract: OBJECTIVE
  There is a lack of evidence on the best treatment option for umbilical granuloma. The primary aim of this study was to compare three treatments for umbilical granuloma: standard treatment with topical silver nitrate, clobetasol propionate cream (0.05%) and ethanol wipes. The secondary aim was to evaluate whether the treatment could be successfully administered by a parent at home, rather than in the outpatient clinic.
  
  
  METHODS
  A total of 109 infants were randomised to one of three groups and 94 infants completed the assigned treatment: 30 infants received standard treatment with silver nitrate (99%) in the outpatient clinic, 30 infants had topical clobetasol propionate cream (0.05%) applied at home, and 34 infants received cleansing with ethanol wipes (82%) at home.
  
  
  RESULTS
  Silver nitrate and clobetasol propionate cream (0.05%) were significantly superior to ethanol wipes, with shorter healing times and higher resolution rates (p = 0.0001). Healing time and resolution rates were identical for silver nitrate and clobetasol propionate cream (0.05%). Mild side effects were occasionally reported, all of which were self-limiting.
  
  
  CONCLUSIONS
  Treating umbilical granuloma with topical clobetasol propionate cream (0.05%) at home is as effective as treating it with topical silver nitrate (99%) in the clinic.
authors.affiliation: Department of Paediatrics, Hvidovre Hospital, The Capital Region, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Anne
authors.initials: A
authors.lastname: Brødsgaard
authors.forename: Tove
authors.initials: T
authors.lastname: Nielsen
authors.forename: Ulla
authors.initials: U
authors.lastname: Mølgaard
authors.forename: Ole
authors.initials: O
authors.lastname: Pryds
authors.forename: Pernille
authors.initials: P
authors.lastname: Pedersen
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D002990:Clobetasol / Q000627:therapeutic use; D000431:Ethanol / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D012835:Silver Nitrate / Q000627:therapeutic use; D012871:Skin Diseases / Q000188:drug therapy*; D014470:Umbilical Cord
chemical_list: D000891:Anti-Infective Agents, Local; D005938:Glucocorticoids; D000431:Ethanol; D012835:Silver Nitrate; D002990:Clobetasol
keywords: Clobetasol propionate cream; Ethanol wipes; Randomised clinical trial; Silver nitrate; Umbilical granuloma