title: A Bad Case of Good's Syndrome.
abstract: Good's syndrome is a relatively rare immunodeficiency condition that presents in the fourth or fifth decade of life and is defined by hypogammaglobulinemia in the setting of a thymoma. The humoral defect may be severe enough to cause an absence in B cells, with a consequent recurrence of sinopulmonary disease, chronic non-infectious diarrhea and opportunistic infections. The prognosis in patients with Good's syndrome appears to be worse than in those with X-linked agammaglobulinemia (XLA) and common variable immune deficiency (CVID). There have only been three cases of Good's syndrome associated with mycobacterium, and only one case with a cavitary lesion in the lungs. We present here a unique case of Good's syndrome with a non-mycobacterial cavitary lesion.
authors.affiliation: Division of Allergy and Clinical Immunology, UCLA School of Medicine, 1301 20th Street, Suite 220, Santa Monica, CA, 90404, USA. RTachdjian@mednet.ucla.edu.
authors.forename: Raffi
authors.initials: R
authors.lastname: Tachdjian
authors.affiliation: Division of Internal Medicine, Kaiser Permanente, Downey, CA, USA.
authors.forename: Janet J
authors.initials: JJ
authors.lastname: Keller
authors.affiliation: Division of Internal Medicine and Health Services Research, UCLA School of Medicine, Los Angeles, CA, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Pfeffer
keywords: Cavitary lesion; Good’s syndrome; Hypogammaglobulinemia; IVIG; Immunodeficiency; Intravenous immunoglobulin; Pneumocystis jiroveci; Thymoma