title: Protective effects of grape seed extract fractions with different degrees of polymerisation on blood glucose, lipids and hepatic oxidative stress in diabetic rats.
abstract: The purpose of this study was to evaluate the effect of grape seed procyanidin (GSPE) fractions with different degrees of polymerisation (DPs) on blood glucose, lipids and hepatic oxidative stress in diabetic rats. Diabetic rats received a daily oral supplement of GSPE with different DPs for 6 weeks. During this period, blood glucose, body weight and food intake were assessed weekly. At the end of the experiment, serum lipid and hepatic oxidative stress were assessed compared with those of rats that did not receive GSPE. GSPE significantly decreased blood glucose, serum lipids and hepatic oxidative stress. Moreover, these effects were significantly better in the groups administered the oligomeric rather than the polymeric forms. These results demonstrate that GSPE has a positive effect on diabetes in rats, and the oligomeric form of GSPE may be more protective than other forms.
authors.affiliation: a College of Food Science, Shenyang Agricultural University , Shenyang , Liaoning Province 110866 , P.R. China.
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Wu
authors.forename: Siyao
authors.initials: S
authors.lastname: Shen
authors.forename: Jiaqian
authors.initials: J
authors.lastname: Jiang
authors.forename: Dehong
authors.initials: D
authors.lastname: Tan
authors.forename: Donghua
authors.initials: D
authors.lastname: Jiang
authors.forename: Bing
authors.initials: B
authors.lastname: Bai
authors.forename: Xiyun
authors.initials: X
authors.lastname: Sun
authors.forename: Shichen
authors.initials: S
authors.lastname: Fu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D056604:Grape Seed Extract / Q000737:chemistry / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008687:Metformin / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D058105:Polymerization; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose; D056604:Grape Seed Extract; D008055:Lipids; D009569:Nitric Oxide; D008315:Malondialdehyde; D008687:Metformin
keywords: antioxidation; diabetes; nitric oxide; procyanidins