title: Mouse models of primary central nervous system lymphomas: tools for basing funding and therapeutic strategies.
abstract: Primary central nervous system lymphomas (PCNSL) include ocular and cerebral lymphomas and are rare aggressive malignancies with poor prognoses. Compared with other lymphomas, they are a challenge for clinicians and scientists, for diagnosis and therapeutic progress and their prognosis remains unsatisfactory, because of the lack of molecular and biological knowledge. Indeed, several limitations of human sample present a major obstacle to the identification of the particular microenvironment of the sanctuary sites where these tumor cells grow. In addition, the generally poor overall condition and performance status of patients with PCNSL limit their participation in prospective trials. Therefore, animal models of PCNSL are essential for tumor microenvironment characterization and for antitumor response studying. In this review, we have compiled the B-and T-cell PCNSL mouse models that are used to improve our understanding of the lymphoma microenvironment, tropism and migration and to investigate novel therapeutic strategies.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMRS 872, Centre de Recherche des Cordeliers, 75006, Paris, France, rym.abdelwahed@yahoo.fr.
authors.forename: Rym
authors.initials: R
authors.lastname: Ben Abdelwahed Bagga
authors.forename: Sabrina
authors.initials: S
authors.lastname: Donnou
authors.forename: Jérémie
authors.initials: J
authors.lastname: Cosette
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.forename: Mahjoub
authors.initials: M
authors.lastname: Aouni
authors.forename: Sylvain
authors.initials: S
authors.lastname: Fisson
mesh_terms: D000818:Animals; D016543:Central Nervous System Neoplasms / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D004195:Disease Models, Animal; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D051379:Mice