title: Total synthesis of hapalindole-type natural products.
abstract: A unified and bioinspired oxidative cyclization strategy was used in the first total syntheses of naturally occurring 12-epi-hapalindole Q isonitrile, hapalonamide H, deschloro 12-epi-fischerindole I nitrile, and deschloro 12-epi-fischerindole W nitrile, as well as the structural revision of the latter. Hapalindoles H and Q were also synthesized.
authors.affiliation: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China).
authors.forename: Zhaohong
authors.initials: Z
authors.lastname: Lu
authors.forename: Ming
authors.initials: M
authors.lastname: Yang
authors.forename: Pengxi
authors.initials: P
authors.lastname: Chen
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Xiong
authors.forename: Ang
authors.initials: A
authors.lastname: Li
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D007211:Indoles
keywords: Prins cyclization; hapalindole; indole terpenoids