title: Infection susceptibility of crosslinked and non-crosslinked biological meshes in an experimental contaminated environment.
abstract: BACKGROUND
  This experimental study investigates infectious complications and functional outcome of biological meshes in a contaminated environment.
  
  
  METHODS
  In 90 rats peritonitis was induced, and after 24 hours, a biological mesh was implanted intraperitoneally including 2 non-crosslinked mesh groups (Strattice and Surgisis) and 2 crosslinked mesh groups (CollaMendFM and Permacol). Sacrifice was after 90 and 180 days.
  
  
  RESULTS
  More mesh infections occurred in crosslinked meshes compared with non-crosslinked meshes (70% vs 4%; P < .001). Mesh infection was the highest in crosslinked CollaMendFM (81.2%) and lowest in non-crosslinked Strattice groups (0%). Incorporation into the abdominal wall was poor in all meshes (0% to 39%). After 180 days no residue of non-crosslinked Surgisis mesh was found. After 180 days, shrinkage was .8% in crosslinked Permacol and 20% in Strattice groups. Strattice showed the least adhesion formation (median 5%).
  
  
  CONCLUSIONS
  Infection rate of biological meshes in a contaminated field was the highest in crosslinked meshes. All biological meshes showed poor incorporation, which makes long-term abdominal wall repair questionable.
authors.affiliation: Laboratory of Experimental Surgery, Department of Surgery, Erasmus University Medical Center, Room Ee-173, P.O. Box 2040, Rotterdam 3000, The Netherlands. Electronic address: irenemulder84@hotmail.com.
authors.forename: Irene M
authors.initials: IM
authors.lastname: Mulder
authors.affiliation: Laboratory of Experimental Surgery, Department of Surgery, Erasmus University Medical Center, Room Ee-173, P.O. Box 2040, Rotterdam 3000, The Netherlands.
authors.forename: Eva B
authors.initials: EB
authors.lastname: Deerenberg
authors.affiliation: Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: Willem A
authors.initials: WA
authors.lastname: Bemelman
authors.affiliation: Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.
authors.forename: Johannes
authors.initials: J
authors.lastname: Jeekel
authors.affiliation: Laboratory of Experimental Surgery, Department of Surgery, Erasmus University Medical Center, Room Ee-173, P.O. Box 2040, Rotterdam 3000, The Netherlands.
authors.forename: Johan F
authors.initials: JF
authors.lastname: Lange
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000453:epidemiology* / Q000209:etiology*; D001672:Biocompatible Materials; D001705:Bioprosthesis / Q000009:adverse effects*; D003094:Collagen; D004198:Disease Susceptibility; D008297:Male; D008422:Materials Testing; D010538:Peritonitis / Q000150:complications / Q000382:microbiology; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000453:epidemiology* / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D013526:Surgical Mesh / Q000009:adverse effects*
chemical_list: D001672:Biocompatible Materials; C422414:Permacol; C568444:strattice; C588278:surgisis; D003094:Collagen
keywords: Adhesion formation; Biological mesh; Complications; Hernia; Incorporation; Infection