title: Phospholipid transfer protein activity and incident type 2 diabetes mellitus.
abstract: BACKGROUND
  The plasma activity of phospholipid transfer protein (PLTP), which has multifaceted functions in lipoprotein metabolism and in inflammatory responses, is elevated in insulin resistant conditions. We determined the association of plasma PLTP activity with incident type 2 diabetes mellitus (T2DM).
  
  
  METHODS
  Plasma PLTP activity was determined using a liposome vesicle-HDL system in 218 men without T2DM at baseline. We used logistic regression models to establish odds ratios (ORs) for incident T2DM.
  
  
  RESULTS
  Twenty four men developed T2DM over 9.4-year follow-up. Plasma PLTP activity was higher in incident T2DM cases (p=0.009). We observed 82% higher odds for T2DM per 1-SD increase in PLTP activity. Multivariable modeling showed that the association of PLTP activity with T2DM was independent of clinical risk factors including age, and either the metabolic syndrome, individual metabolic syndrome components, total cholesterol, HOMA-IR or albuminuria (ORs ranging from 1.64 (95% CI 1.03-2.66) to 1.87 (1.19-3.010)).
  
  
  CONCLUSIONS
  Elevated plasma PLTP activity may predict an increased risk of T2DM in men.
authors.affiliation: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Addenbrooke's Hospital, P.O. Box 285, Cambridge CB2 0QQ, UK; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
authors.forename: Ali
authors.initials: A
authors.lastname: Abbasi
authors.affiliation: Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands.
authors.forename: Geesje M
authors.initials: GM
authors.lastname: Dallinga-Thie
authors.affiliation: Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: r.p.f.dullaart@umcg.nl.
authors.forename: Robin P F
authors.initials: RP
authors.lastname: Dullaart
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049294:Phospholipid Transfer Proteins / Q000097:blood / Q000378:metabolism*
chemical_list: C493430:PLTP protein, human; D049294:Phospholipid Transfer Proteins
keywords: Epidemiology; Phospholipid transfer protein activity; Risk factor; Type 2 diabetes mellitus