title: Computational modelling of the hybrid procedure in hypoplastic left heart syndrome: a comparison of zero-dimensional and three-dimensional approach.
abstract: Previous studies have employed generic 3D-multiscale models to predict haemodynamic effects of the hybrid procedure in hypoplastic left heart syndrome. Patient-specific models, derived from image data, may allow a more clinically relevant model. However, such models require long computation times and employ internal pulmonary artery band [dint] dimension, which limits clinical application. Simpler, zero-dimensional models utilize external PAB diameters [dext] and provide rapid analysis, which may better guide intervention. This study compared 0-D and 3-D modelling from a single patient dataset and investigated the relationship dint versus dext and hemodynamic outputs of the two models. Optimum oxygen delivery defined at dint=2mm corresponded to dext=3.1 mm and 3.4 mm when models were matched for cardiac output or systemic pressure, respectively. 0-D and 3-D models when matched for PAB dimension produced close equivalence of hemodynamics and ventricular energetics. From this study we conclude that 0-D model can provide a valid alternative to 3D-multiscale in the hybrid-HLHS circulation.
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, UK; Department of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Andrew
authors.initials: A
authors.lastname: Young
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Terry
authors.initials: T
authors.lastname: Gourlay
authors.affiliation: Department of Mathematics and Statistics, University of Strathclyde, Glasgow, Scotland, UK.
authors.forename: Sean
authors.initials: S
authors.lastname: McKee
authors.affiliation: Department of Biomedical Engineering, University of Strathclyde, Glasgow, Scotland, UK; Department of Cardiac Surgery, Royal Hospital for Sick Children, Glasgow, Scotland, UK. Electronic address: danton.mark@googlemail.com.
authors.forename: Mark H D
authors.initials: MH
authors.lastname: Danton
mesh_terms: D006439:Hemodynamics; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000473:pathology* / Q000503:physiopathology*; D066230:Patient-Specific Modeling; D011651:Pulmonary Artery / Q000473:pathology / Q000503:physiopathology
keywords: Computational modelling; Hybrid procedure; Hypoplastic left heart syndrome