title: Photodynamic therapy effect of zinc monoamino phthalocyanine-folic acid conjugate adsorbed on single walled carbon nanotubes on melanoma cells.
abstract: This work reports on the photodynamic therapy effect of zinc monoamino phthalocyanine linked to folic acid represented as ZnMAPc-FA, which was further immobilized onto single walled carbon nanotube represented as ZnMAPc-FA-SWCNT on melanoma A375 cell line, the effect of SWCNT-FA (without ZnMAPc) was also examined. All the compounds were non-toxic to the melanoma A375 cell line in the absence of light. Upon irradiation of the melanoma A375 cell line with a 676 nm diode laser at a power density of 98 mW/cm(2) at 5 J/cm(2) about 60% and 63% cell death was observed in the presence of ZnMAPc-FA and ZnMAPc-FA-SWCNT respectively. SWCNT-FA had no significant photodynamic therapy or photothermal effect to the cell, only 23% of cell death was observed after irradiation.
authors.affiliation: Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South Africa.
authors.forename: Racheal O
authors.initials: RO
authors.lastname: Ogbodu
authors.affiliation: Biophotonics, National Laser Centre, CSIR, Pretoria 0001, South Africa.
authors.forename: Ivy
authors.initials: I
authors.lastname: Ndhundhuma
authors.affiliation: Biophotonics, National Laser Centre, CSIR, Pretoria 0001, South Africa.
authors.forename: Aletta
authors.initials: A
authors.lastname: Karsten
authors.affiliation: Rhodes University, Chemistry Department, Rhodes University, Grahamstown 6140, South Africa. Electronic address: t.nyokong@ru.ac.za.
authors.forename: Tebello
authors.initials: T
authors.lastname: Nyokong
mesh_terms: D045744:Cell Line, Tumor; D005492:Folic Acid; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D054833:Isoindoles; D008545:Melanoma / Q000188:drug therapy*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology; D014803:Vitamin B Complex / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D007211:Indoles; D054833:Isoindoles; D037742:Nanotubes, Carbon; D011838:Radiation-Sensitizing Agents; D014803:Vitamin B Complex; D005492:Folic Acid; D015032:Zinc; C013647:phthalocyanine
keywords: Folic acid; Melanoma cells; Photodynamic therapy; Single walled carbon nanotubes