title: A seco-catechin cyclization approach to 4→6-linked catechin dimers.
abstract: A viable route has been developed for the selective synthesis of the 4→6-linked catechin dimers, scarcely accessible from Nature and/or through synthesis. An acyclic nucleophilic catechin precursor (seco-catechin) was used for the regioselective union with an electrophilic catechin unit, and subsequent pyran cyclization gave the desired 4→6-linked dimers, i.e., procyanidin B6 and catechin-(4α→6)-gallocatechin.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro, Tokyo 152-8551, Japan. kohmori@chem.titech.ac.jp ksuzuki@chem.titech.ac.jp.
authors.forename: Gen
authors.initials: G
authors.lastname: Watanabe
authors.forename: Ken
authors.initials: K
authors.lastname: Ohmori
authors.forename: Keisuke
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D002392:Catechin / Q000737:chemistry*; D003500:Cyclization; D019281:Dimerization
chemical_list: D002392:Catechin