title: Five-year follow-up study of the association between periodontal disease and myocardial infarction among Japanese male workers: MY Health Up Study.
abstract: BACKGROUND
  An association between chronic oral infections and coronary heart disease has been suggested.
  
  
  METHODS
  The study participants were male employees aged 36-59 years. Data were extracted from the MY Health Up Study, comprising a baseline questionnaire survey and succeeding annual health examinations for financial firm workers in Japan. Using a self-administered questionnaire at baseline, participants' oral status was classified into three types of periodontal indicators: (i) periodontal score, (ii) periodontitis and (iii) tooth loss (<5 and ≥5 teeth). An incidence of myocardial infarction (MI) was determined by annual health examination records.
  
  
  RESULTS
  Of the 4037 candidates for follow-up in the baseline year of 2004, 3081 males were eligible for the analysis, 17 of whom experienced MI in the subsequent 5 years. The periodontal score model was associated with an increase in developing MI [odds ratio (OR) = 2.11, 95% confidence interval (CI) = 1.29-3.44], after adjusting for other confounding variables. The periodontitis (OR = 2.26, 95% CI = 0.84-6.02) and tooth loss (OR = 1.97, 95% CI = 0.71-5.45) models showed similar trends, although the difference was not significant.
  
  
  CONCLUSIONS
  Periodontal disease may be a mild but independent risk factor for MI among Japanese male workers.
authors.affiliation: Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan Department of Health Policy and Technology Assessment, National Institute of Public Health, Saitama, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Noguchi
authors.affiliation: Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Toyokawa
authors.affiliation: Division of Health Promotion, Meiji Yasuda Life Insurance Company, Tokyo, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Miyoshi
authors.affiliation: Meiji Yasuda Shinjuku Medical Center, Meiji Yasuda Life Foundation of Health and Welfare, Tokyo, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Suyama
authors.affiliation: Department of Community Medicine, Chiba Medical Center, Teikyo University School of Medicine, Chiba, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Inoue
authors.affiliation: Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology*; D010510:Periodontal Diseases / Q000150:complications* / Q000453:epidemiology; D011159:Population Surveillance
keywords: circulatory disease; dentistry and oral health