title: Data identification for improving gene network inference using computational algebra.
abstract: Identification of models of gene regulatory networks is sensitive to the amount of data used as input. Considering the substantial costs in conducting experiments, it is of value to have an estimate of the amount of data required to infer the network structure. To minimize wasted resources, it is also beneficial to know which data are necessary to identify the network. Knowledge of the data and knowledge of the terms in polynomial models are often required a priori in model identification. In applications, it is unlikely that the structure of a polynomial model will be known, which may force data sets to be unnecessarily large in order to identify a model. Furthermore, none of the known results provides any strategy for constructing data sets to uniquely identify a model. We provide a specialization of an existing criterion for deciding when a set of data points identifies a minimal polynomial model when its monomial terms have been specified. Then, we relax the requirement of the knowledge of the monomials and present results for model identification given only the data. Finally, we present a method for constructing data sets that identify minimal polynomial models.
authors.affiliation: Department of Mathematical Sciences, Clemson University, Clemson, SC, 29634, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Dimitrova
authors.forename: Brandilyn
authors.initials: B
authors.lastname: Stigler
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics; D003627:Data Interpretation, Statistical; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D017238:Genes, Helminth; D055641:Mathematical Concepts; D008957:Models, Genetic; D049490:Systems Biology