title: Association of Epstein Barr virus A73 gene polymorphism with nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To study the association between Epstein Barr (EB) virus A73 gene polymorphism and nasopharyngeal carcinoma (NPC) in a Chinese Han population.
  
  
  METHODS
  A case-control study was designed, including 510 nasopharyngeal cancer patients and 520 healthy controls, A157154C genotypes of the A73 gene in EB virus were detected, genotype and allele frequency distribution between the two groups were compared.
  
  
  RESULTS
  The C allele frequency in the NPC group was significantly higher than that in the control group (68.4% vs. 61.2%; p<0.001). The CC genotype frequency in the NPC group was significantly higher than that in the control group, the difference was significant (47.4% vs. 41.2%; p<0.001). The CC genotype frequency in male patients was significantly higher than that in female patients in the NPC group, the difference was significant (50.3% vs. 34.7%; p<0.001).
  
  
  CONCLUSIONS
  A157154C polymorphism of the A73 gene in EB virus was associated with NPC susceptibility.
authors.affiliation: 1 Department of Radiation Oncology, Anhui Provincial Hospital , Hefei, China .
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Shen
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Niu
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D002277:Carcinoma; D020031:Epstein-Barr Virus Infections / Q000235:genetics*; D005260:Female; D005814:Genes, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000821:virology; D011110:Polymorphism, Genetic