title: Long-term periodontal tissue outcome in regenerated infrabony and furcation defects: a systematic review.
abstract: OBJECTIVE
  This study aimed to systematically evaluate the long-term results of periodontal tissues in regenerated infrabony and furcation defects.
  
  
  METHODS
  A search of the Medline database was performed (1960 to 2012), complimented by an additional hand search. For inclusion in the review, clinical trials had to include the long-term evaluation of infrabony and furcation defects submitted to periodontal regeneration for up to 3 years of follow-up. Changes in clinical attachment level (CAL) from pre-surgery, at the first post-surgical, and final evaluations were used to analyze the effects of regenerative treatments over time.
  
  
  RESULTS
  A total of 866 articles were found using the descriptors employed. Of these, 216 papers were selected for abstract reading by two evaluators. One hundred and eighty-nine were excluded for not fulfilling the eligibility criteria. Twenty-seven papers were selected for the analysis of the full texts, and 13 were excluded. Two studies were included after a manual search. Finally, 16 papers were selected for the present review.
  
  
  CONCLUSIONS
  Regenerative techniques for the treatment of infrabony and furcation defects resulted in improved CAL during long-term follow-up periods, even when attachment losses occurred during this period. This improvement should be carefully evaluated with regard to its clinical relevance for dental longevity.
  
  
  CONCLUSIONS
  The improvement in clinical attachment level achieved by regenerative techniques with biomaterials demonstrated satisfactory results over the long-term. However, regenerative techniques still present different success rates with regard to gain in clinical attachment level.
authors.affiliation: Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, 59056-000, Brazil.
authors.forename: Eduardo Aleixo
authors.initials: EA
authors.lastname: Figueira
authors.forename: Angélica Oliveira
authors.initials: AO
authors.lastname: de Assis
authors.forename: Sheyla Christinne Lira
authors.initials: SC
authors.lastname: Montenegro
authors.forename: Diego Moura
authors.initials: DM
authors.lastname: Soares
authors.forename: Anna Angélica Araújo
authors.initials: AA
authors.lastname: Barros
authors.forename: Euler Maciel
authors.initials: EM
authors.lastname: Dantas
authors.forename: Bruno César
authors.initials: BC
authors.lastname: de Vasconcelos Gurgel
mesh_terms: D006801:Humans; D010519:Periodontium / Q000503:physiopathology*; D012038:Regeneration