title: Mean platelet volume in patients with acute coronary syndromes: a supportive diagnostic predictor.
abstract: BACKGROUND
  Platelets and their activity have a crucial role in acute coronary events. Larger platelets are enzymatically and metabolically more active and have a higher potential thrombotic ability as compared with smaller platelets.
  
  
  OBJECTIVE
  The aim of this study is to investigate whether there is an association between mean platelet volume (MPV) measurement and cardiac Troponin I( cTn I ) in patients admitted with a suspected diagnosis of ACS and to assess the potential diagnostic efficiency of MPV in the diagnostic workup for ACS.
  
  
  METHODS
  After thorough evaluation of 215 eligible patients, 3 ml. Venous blood collected using Becton, Dickinson and company vacutainer and MPV measured within 1-2 hr of sample collection. Sample for cTn I collected at 6 hr and at 12 hrs, if required and level measured using Biosite analyzer.
  
  
  RESULTS
  Mean platelet volume (MPV) was found to be higher among ACS patients as compared to non ACS, 11.44±1.23 vs 9.91±1.27 fl (p-value<0.001). The NPV of MPV in the diagnostic workup of chest pain suggestive of ACS within 6 hours of presentation were found to be 82.53% .
  
  
  CONCLUSIONS
  In this study the MPV is significantly higher in patients with ACS than in those with chest pain of non-cardiac origin and its negative predictive value of 82.53%, it might be useful as an assisting rule-out test in conjunction with other markers in the early prediction of the risk of ACS.
authors.affiliation: Senior Cardiologist, Department of Cardiology, SMS Medical College , Jaipur, Rajasthan, India .
authors.forename: Randheer
authors.initials: R
authors.lastname: Pal
authors.affiliation: Professor, Department of Cardiology, SMS Medical College , Jaipur, Rajasthan, India .
authors.forename: Rajeev
authors.initials: R
authors.lastname: Bagarhatta
authors.affiliation: Professor, Department of Cardiology, SMS Medical College , Jaipur, Rajasthan, India .
authors.forename: Sandhya
authors.initials: S
authors.lastname: Gulati
authors.affiliation: Professor, Department of Cardiology, SMS Medical College , Jaipur, Rajasthan, India .
authors.forename: Monika
authors.initials: M
authors.lastname: Rathore
authors.affiliation: Professor, Department of Cardiology, SMS Medical College , Jaipur, Rajasthan, India .
authors.forename: Nidhi
authors.initials: N
authors.lastname: Sharma
keywords: Acute coronary syndromes; Cardiac troponin I; Mean platelet volume