title: Bench-to-bedside challenges in developing immune protection against breast cancer.
abstract: Despite the success of childhood vaccination against infectious diseases, vaccines are lacking against diseases that occur with age. We are developing a vaccine to prevent breast cancer. This article explains the vaccine strategy, how we think the vaccine will work, and how we plan to move forward through clinical trials.
authors.affiliation: Mort and Iris November Distinguished Chair in Innovative Breast Cancer Research, Cleveland Clinic; Staff, Department of Immunology, Lerner Research Institute, Cleveland Clinic; Professor, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH; Chief Science Officer, Shield Biotech, Inc. tuohyv@ccf.org.
authors.forename: Vincent K
authors.initials: VK
authors.lastname: Tuohy
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy; D019496:Cancer Vaccines / Q000276:immunology / Q000494:pharmacology; D063646:Carcinogenesis / Q000187:drug effects / Q000276:immunology; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007768:Lactalbumin / Q000276:immunology / Q000494:pharmacology
chemical_list: D019496:Cancer Vaccines; D007768:Lactalbumin