title: Novel variation in the FABP3 promoter and its association with fatness traits in pigs.
abstract: This study examines associations between SNPs in the promoter region of the fatty acid binding protein 3 (FABP3) gene and fatness traits in pure bred Large White (n=98), Duroc (n=99) and Pietrain (n=98) populations. In the Large White breed, SNP g.-634 C>A was associated a 27% increase in IMF (%) in the heterozygote (CA) and a 38% increase in the homozygote (CC) relative to the (AA) genotype in the M. semimembranosus (SM) muscle (P=0.02). While the associations observed in this breed were suggestive of significance in both the SM and in the M. longissimus thoracis et lumborum (LTL) (P=0.08), these associations no longer attained significance at thresholds adjusted for multiple testing. In conclusion, SNPs in the FABP3 promoter may contribute to IMF without influencing carcass fatness traits in pigs, however further confirmation of these associations in larger independent populations would be essential before their incorporation into breeding programmes.
authors.affiliation: School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: T
authors.initials: T
authors.lastname: Sweeney
authors.affiliation: School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
authors.forename: A M
authors.initials: AM
authors.lastname: O'Halloran
authors.affiliation: Teagasc, Ashtown Food Research Centre, Ashtown, Dublin 15, Ireland.
authors.forename: R M
authors.initials: RM
authors.lastname: Hamill
authors.affiliation: Functional Genomics & Glycomics Group, Martin Ryan Institute, National University of Ireland Galway, Galway, Ireland.
authors.forename: G C
authors.initials: GC
authors.lastname: Davey
authors.affiliation: IRTA, 17121, Monells, Girona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Gil
authors.affiliation: Genus PLC/PIC, Alpha Building, London Road, Nantwich CW5 7JW, UK.
authors.forename: O I
authors.initials: OI
authors.lastname: Southwood
authors.affiliation: School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: marion.ryan@ucd.ie.
authors.forename: M T
authors.initials: MT
authors.lastname: Ryan
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001823:Body Composition / Q000235:genetics*; D001947:Breeding; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006239:Haplotypes; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008460:Meat / Q000032:analysis*; D018482:Muscle, Skeletal / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013552:Swine / Q000235:genetics
chemical_list: C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins
keywords: Carcass; Duroc; Fatty acid binding protein; Intramuscular fat; Large White; Pietrain