title: Innate immune sensing of nucleic acids from mycobacteria.
abstract: Endosomal and cytosolic receptors engage recognition of mycobacterial-derived nucleic acids (MyNAs). In contrast, virulent mycobacteria may utilize nucleic acid recognition pathways to escape the host immune system. This short review will summarize the mechanisms by which MyNAs are sensed and how they influence host protective responses.
authors.affiliation: Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Brazil; Pharmacology Graduate Program, Federal University of Santa Catarina, Brazil.
authors.forename: Lívia Harumi
authors.initials: LH
authors.lastname: Yamashiro
authors.affiliation: Laboratory of Immunology and Infectious Diseases, Federal University of Minas Gerais, Brazil.
authors.forename: Sérgio Costa
authors.initials: SC
authors.lastname: Oliveira
authors.affiliation: Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Brazil; Pharmacology Graduate Program, Federal University of Santa Catarina, Brazil. Electronic address: andre.bafica@ufsc.br.
authors.forename: André
authors.initials: A
authors.lastname: Báfica
mesh_terms: D000818:Animals; D004269:DNA, Bacterial / Q000276:immunology; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate / Q000502:physiology*; D009161:Mycobacterium / Q000235:genetics / Q000276:immunology*; D009164:Mycobacterium Infections / Q000276:immunology* / Q000378:metabolism; D009696:Nucleic Acids / Q000276:immunology*; D012329:RNA, Bacterial / Q000276:immunology; D015398:Signal Transduction
chemical_list: D004269:DNA, Bacterial; D009696:Nucleic Acids; D012329:RNA, Bacterial
keywords: Acid nucleics; Mycobacteria; Sensors; Tuberculosis