title: Comparison of the analgesic effects of cryoanalgesia vs. parecoxib for lung cancer patients after lobectomy.
abstract: This study was designed to compare the analgesic effects of cryoanalgesia and parecoxib in lung cancer patients after lobectomy. A total of 178 lung cancer patients awaiting large-sized lobectomy were enrolled in the study. The patients were randomly divided into Group A (intercostal nerve cryoanalgesia) and Group B (parecoxib). The analgesic and adverse effects were compared between the two groups. The pain score of Group A was significantly lower than that of Group B (P < 0.05). The patients in Group A used significantly less morphine than those in Group B (P < 0.05). There were also significantly fewer complications in Group A than in Group B (P < 0.05). Cryoanalgesia of the intercostal nerves can be considered an economical, safe and simple technique for the long-term management of post-lobectomy pain.
authors.affiliation: Department of Thoracic Surgery, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), 127 Dongming Rd, Zhengzhou, 450008, Henan Province, People's Republic of China.
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Ba
authors.affiliation: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Li
authors.affiliation: Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Ning
authors.affiliation: Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, USA.
authors.forename: Hanze
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Scientific Research and Foreign Affairs, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), Zhengzhou, China.
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Liu
authors.affiliation: Department of Thoracic Surgery, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), 127 Dongming Rd, Zhengzhou, 450008, Henan Province, People's Republic of China.
authors.forename: Shan-Hong
authors.initials: SH
authors.lastname: He
authors.affiliation: Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), Zhengzhou, China.
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Li
authors.affiliation: Department of General Surgery, No. 153 Hospital of Liberation Army, Zhengzhou, China.
authors.forename: Quan-Hui
authors.initials: QH
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Henan Cancer Hospital (The Affiliated Cancer Hospital of Zhengzhou University), 127 Dongming Rd, Zhengzhou, 450008, Henan Province, People's Republic of China. liyinhenan@163.com.
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D050785:Cryoanesthesia / Q000009:adverse effects; D005260:Female; D006801:Humans; D007367:Intercostal Nerves; D007555:Isoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control / Q000628:therapy*; D011013:Pneumonectomy
chemical_list: D007555:Isoxazoles; D009020:Morphine; C409945:parecoxib
keywords: Analgesic effects; Cryoanalgesia; Lobectomy; Parecoxib