title: Novel formulations for antimicrobial peptides.
abstract: Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.
authors.affiliation: Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil. amcr@usp.br.
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Carmona-Ribeiro
authors.affiliation: Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil. lemelodias@usp.br.
authors.forename: Letícia Dias
authors.initials: LD
authors.lastname: de Melo Carrasco
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D016572:Cyclosporine / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; D001672:Biocompatible Materials; D004337:Drug Carriers; D008051:Lipid Bilayers; D016572:Cyclosporine