title: Risk Factors for Early Mortality on Antiretroviral Treatment of Elderly People Infected with HIV in Burkina Faso.
abstract: BACKGROUND
  Age is a key determinant of mortality due to diseases including HIV infection.
  
  
  METHODS
  A retrospective and descriptive cohort study used a computerized database to compare HIV-infected patients diagnosed in late adulthood to a group of patients diagnosed before their 49 years of age, without matching the characteristics of HIV infection. The study included patients who visited the day hospital (outpatient clinic) of the Sanou Souro Teaching Hospital of Bobo-Dioulasso, in Burkina Faso, from January 2007 to December 2011. Older adults were defined as those aged 50 years and more.
  
  
  RESULTS
  Participants in the study consisted of 2572 patients (265 older adults and 2307 young patients living with HIV. Based on Markov chain method, 32.1% of the older adults living with HIV were found to be seroconvert at 50 years or older. The median follow-up time on antiretroviral treatment (ART) was 32.7 months (range 0.03-65.4 months). Two hundred and ninety-five (11.5%) patients died, including 21.1% of older adults and 10.4% of young (P < .01). World Health Organization stage 3 or 4 and the lowest CD4 count reached <200 cells/mm(3) were the factors associated with early mortality of older adults on ART.
  
  
  CONCLUSIONS
  Mortality rate of older adult patients living with HIV in Burkina Faso is high. Early diagnosis, early treatment, and primary prevention of HIV infection in the older adults are the main keys that could help reduce such mortality.
authors.affiliation: Internal Medicine Department, Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso ouedd@yahoo.fr.
authors.forename: Dieu-Donné
authors.initials: DD
authors.lastname: Ouédraogo
authors.affiliation: Internal Medicine Department, Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso.
authors.forename: Lynda Magali
authors.initials: LM
authors.lastname: Sawadogo
authors.affiliation: Internal Medicine Department, Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso.
authors.forename: Yempabou
authors.initials: Y
authors.lastname: Sagna
authors.affiliation: Infectious Department, Sanou Souro Teaching Hospital, Bobo-Dioulasso, Burkina Faso.
authors.forename: Adrien B
authors.initials: AB
authors.lastname: Sawadogo
authors.affiliation: Internal Medicine Department, Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso.
authors.forename: Ismael
authors.initials: I
authors.lastname: Diallo
authors.affiliation: Infectious Department, Sanou Souro Teaching Hospital, Bobo-Dioulasso, Burkina Faso.
authors.forename: Arsène
authors.initials: A
authors.lastname: Hema
authors.affiliation: Infectious Department, Sanou Souro Teaching Hospital, Bobo-Dioulasso, Burkina Faso.
authors.forename: Armel
authors.initials: A
authors.lastname: Poda
authors.affiliation: Internal Medicine Department, Yalgado Ouédraogo Teaching Hospital, Ouagadougou, Burkina Faso.
authors.forename: Youssouf Joseph
authors.initials: YJ
authors.lastname: Drabo
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002050:Burkina Faso / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D019380:Anti-HIV Agents
keywords: Burkina Faso; HIV/AIDS; mortality; older adults; risk factors; sub-Saharan Africa