title: Human skin dendritic cells in health and disease.
abstract: Dendritic cells (DCs) are specialized antigen presenting cells abundant in peripheral tissues such as skin where they function as immune sentinels. Skin DCs migrate to draining lymph node where they interact with naïve T cells to induce immune responses to microorganisms, vaccines, tumours and self-antigens. In this review, we present the key historical developments and recent advances in human skin DC research. We also integrate the current understanding on the origin and functional specializations of DC subsets in healthy skin with findings in inflammatory skin diseases focusing on psoriasis and atopic eczema. A comprehensive understanding of the dynamic changes in DC subsets in health and disease will form a strong foundation to facilitate the clinical translation of DC-based therapeutic and vaccination strategies.
authors.affiliation: Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK; Department of Dermatology, Newcastle Upon Tyne NHS Trust, NE1 4LP, UK. Electronic address: m.a.haniffa@ncl.ac.uk.
authors.forename: Muzlifah
authors.initials: M
authors.lastname: Haniffa
authors.affiliation: Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK.
authors.forename: Merry
authors.initials: M
authors.lastname: Gunawan
authors.affiliation: Institute of Cellular Medicine, Newcastle University, NE2 4HH, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Jardine
mesh_terms: D000954:Antigens, Surface / Q000502:physiology; D018845:CD11 Antigens / Q000502:physiology; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007801:Langerhans Cells / Q000145:classification / Q000276:immunology* / Q000473:pathology; D018950:Lipopolysaccharide Receptors / Q000502:physiology; D012157:Mononuclear Phagocyte System / Q000502:physiology; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D018180:Thrombomodulin
chemical_list: D000954:Antigens, Surface; D018845:CD11 Antigens; D018950:Lipopolysaccharide Receptors; C546931:THBD protein, human; D018180:Thrombomodulin
keywords: Antigen presenting cells; Dendritic cells; Mononuclear phagocytes; Skin