title: Sleep and inflammation in resilient aging.
abstract: Sleep quality is important to health, and increasingly viewed as critical in promoting successful, resilient aging. In this review, the interplay between sleep and mental and physical health is considered with a focus on the role of inflammation as a biological pathway that translates the effects of sleep on risk of depression, pain and chronic disease risk in aging. Given that sleep regulates inflammatory biologic mechanisms with effects on mental and physical health outcomes, the potential of interventions that target sleep to reduce inflammation and promote health in aging is also discussed.
authors.affiliation: Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience , University of California , Los Angeles, CA , USA ; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine , University of California , Los Angeles, CA , USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Irwin
keywords: aging; depression; inflammation; mortality; resilience pain; sleep