title: Fabrication of monodisperse liposomes-in-microgel hybrid microparticles in capillary-based microfluidic devices.
abstract: This study introduces a drop-based microfluidic approach to physically immobilize liposomes in microgel (liposomes-in-microgel) particles. For this, we generate a uniform liposomes-in-water-in-oil emulsion in a capillary-based microfluidic device. Basically, we have investigated how the flow rate and flow composition affect generation of emulsion precursor drops in micro-channels. Then, the precursor emulsion drops are solidified by photo-polymerization. From characterization of hydrogel mesh sizes, we have figured out that the mesh size of the liposomes-in-microgel particles is bigger than that of bare microgel particles, since liposomes take space in the hydrogel phase. In our further study on drug releasing, we have observed that immobilization of liposomes in the microgel particles can not only remarkably retard drug releasing, but also enables a sustained release, which stems from the enhanced matrix viscosity of the surrounding hydrogel phase.
authors.affiliation: Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea.
authors.forename: Eun Seon
authors.initials: ES
authors.lastname: Jeong
authors.affiliation: Korea Institute of Geoscience and Mineral Resources, Daejeon 305-350, Republic of Korea.
authors.forename: Han Am
authors.initials: HA
authors.lastname: Son
authors.affiliation: Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea.
authors.forename: Min Kyung
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Applied Chemistry, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea. Electronic address: piroho@hanyang.ac.kr.
authors.forename: Kyoung-Ho
authors.initials: KH
authors.lastname: Park
authors.affiliation: Hwa Costech Co., Seongnam, Gyeonggi-do 463-863, Republic of Korea.
authors.forename: Sechan
authors.initials: S
authors.lastname: Kay
authors.affiliation: Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea.
authors.forename: Pil Seok
authors.initials: PS
authors.lastname: Chae
authors.affiliation: Department of Bionano Technology, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea; Department of Applied Chemistry, Hanyang University, Ansan, Gyeonggi-do 426-791, Republic of Korea. Electronic address: kjwoong@hanyang.ac.kr.
authors.forename: Jin Woong
authors.initials: JW
authors.lastname: Kim
mesh_terms: D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D044085:Microfluidics / Q000379:methods*
chemical_list: D008081:Liposomes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: Drug releasing; Hydrogel mesh size; Liposome; Microfluidics; Microgel