title: Antidiabetic activities of chitosan and its derivatives: a mini review.
abstract: Obesity and diabetes are two important closely related matters to world health with increasing morbidity and mortality rate. Many recent studies promoted chitosan-based substances as lead molecules for treatment and prevention of obesity, diabetes, and related complications due to their easy and potential utilization in the food, pharmaceutical, agricultural, and environmental fields. Although detailed action mechanism and how chitosan-based molecules act as antidiabetics and antiobesity specifically are remain to be enlightened, studies exhibited enough evidence to direct our intention to produce natural therapeutic agents using chitosan and its derivatives as lead substances. In this chapter, some reported antidiabetics and antiobesity applications of chitosan and its derivatives have been briefly summarized in regard to acting pathways and structure-based activity in order to obtain some valuable insights into novel chitosan-based derivatives and their utilization for antidiabetic and antiobesity purposes.
authors.affiliation: Marine Bioprocess Research Center, Pukyong National University, Busan, South Korea.
authors.forename: Fatih
authors.initials: F
authors.lastname: Karadeniz
authors.affiliation: Marine Bioprocess Research Center, Pukyong National University, Busan, South Korea. Electronic address: sknkim@pknu.ac.kr.
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents; D048271:Chitosan / Q000031:analogs & derivatives / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents; D013329:Structure-Activity Relationship
chemical_list: D019440:Anti-Obesity Agents; D007004:Hypoglycemic Agents; D048271:Chitosan
keywords: Chitosan; Chitosan oligosaccharides; Diabetes; Glucosamine