title: Distinct structural neural patterns of trait physical and social anhedonia: evidence from cortical thickness, subcortical volumes and inter-regional correlations.
abstract: Anhedonia is an enduring trait accounting for the reduced capacity to experience pleasure. Few studies have investigated the brain structural features associated with trait anhedonia. In this study, the relationships between cortical thickness, volume of subcortical structures and scores on the Chapman physical and social anhedonia scales were examined in a non-clinical sample (n=72, 35 males). FreeSurfer was used to examine the cortical thickness and the volume of six identified subcortical structures related to trait anhedonia. We found that the cortical thickness of the superior frontal gyrus and the volume of the pallidum in the left hemisphere were correlated with anhedonia scores in both physical and social aspects. Specifically, positive correlations were found between levels of social anhedonia and the thickness of the postcentral and the inferior parietal gyri. Cortico-subcortical inter-correlations between these clusters were also observed. Our findings revealed distinct correlation patterns of neural substrates with trait physical and social anhedonia in a non-clinical sample. These findings contribute to the understanding of the pathologies underlying the anhedonia phenotype in schizophrenia and other psychiatric disorders.
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China; Cognitive Analysis & Brain Imaging Laboratory, MIND Institute, University of California, Davis, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China.
authors.forename: Germaine
authors.initials: G
authors.lastname: Fung
authors.affiliation: School of Health Management, Guangzhou Medical University, Guangzhou, China.
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Liu
authors.affiliation: Department of Radiology, Guangzhou First People׳s Hospital, Guangzhou, China.
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Wei
authors.affiliation: Department of Radiology, Guangzhou First People׳s Hospital, Guangzhou, China.
authors.forename: Xin-qing
authors.initials: XQ
authors.lastname: Jiang
authors.affiliation: Castle Peak Hospital, Hong Kong Special Administrative Region.
authors.forename: Simon S Y
authors.initials: SS
authors.lastname: Lui
authors.affiliation: Castle Peak Hospital, Hong Kong Special Administrative Region.
authors.forename: Eric F C
authors.initials: EF
authors.lastname: Cheung
authors.affiliation: Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China; Magnetic Resonance Imaging Research Centre, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China. Electronic address: rckchan@psych.ac.cn.
authors.forename: Raymond C K
authors.initials: RC
authors.lastname: Chan
mesh_terms: D000293:Adolescent; D000328:Adult; D059445:Anhedonia / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000502:physiology; D005260:Female; D005917:Globus Pallidus / Q000033:anatomy & histology* / Q000502:physiology; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology* / Q000502:physiology; D055815:Young Adult
keywords: Anhedonia; Inferior parietal gyrus; Pallidum; Social interaction; Superior frontal gyrus