title: HTLV-1 bZIP factor suppresses the centromere protein B (CENP-B)-mediated trimethylation of histone H3K9 through the abrogation of DNA-binding ability of CENP-B.
abstract: Human T-cell leukaemia virus type-1 (HTLV-1) infection causes adult T-cell leukaemia (ATL). The viral protein HTLV-1 bZIP factor (HBZ) is constitutively expressed in ATL cells, suggesting that HBZ plays a major role in the pathogenesis of HTLV-1-associated disease. Here, we identified centromere protein B (CENP-B) as a novel interacting partner of HBZ. HBZ and CENP-B associate with their central regions in cells. Furthermore, overexpression of HBZ abrogated the DNA-binding activity of CENP-B to the α-satellite DNA region containing the CENP-B box motif, which in turn inhibited the CENP-B-mediated trimethylation of histone H3K9 in T-cells.
authors.affiliation: Graduate School of Engineering, Tokushima Bunri University, Sanuki, Kagawa, Japan.
authors.forename: Risa
authors.initials: R
authors.lastname: Mukai
authors.affiliation: Faculty of Pharmaceutical Science at Kagawa Campus, Tokushima Bunri University, Sanuki, Kagawa, Japan.|Graduate School of Engineering, Tokushima Bunri University, Sanuki, Kagawa, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ohshima
mesh_terms: D002460:Cell Line; D051936:Centromere Protein B / Q000378:metabolism*; D019175:DNA Methylation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D057809:HEK293 Cells; D015490:HTLV-I Infections / Q000378:metabolism* / Q000821:virology; D006657:Histones / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000378:metabolism; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism* / Q000821:virology; D013601:T-Lymphocytes / Q000378:metabolism / Q000821:virology; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: C497926:CENPB protein, human; D051936:Centromere Protein B; D004268:DNA-Binding Proteins; D006657:Histones; D014764:Viral Proteins