title: Milk, yogurt, and lactose intake and ovarian cancer risk: a meta-analysis.
abstract: Inconclusive information for the role of dairy food intake in relation to ovarian cancer risk may associate with adverse effects of lactose, which has been hypothesized to increase gonadotropin levels in animal models and ecological studies. Up to now, several studies have indicated the association between dairy food intake and risk of ovarian cancer, but no identified founding was reported. We performed this meta-analysis to derive a more precise estimation of the association between dairy food intake and ovarian cancer risk. Using the data from 19 available publications, we examined dairy food including low-fat/skim milk, whole milk, yogurt and lactose in relation to risk of ovarian cancer by meta-analysis. Pooled odds ratio (OR) with 95% confidence interval (CI) were used to assess the association. We observed a slightly increased risk of ovarian cancer with high intake of whole milk, but has no statistical significance (OR = 1.228, 95% CI = 1.031-1.464, P = 0.022). The results of other milk models did not provide evidence of positive association with ovarian cancer risk. This meta-analysis suggests that low-fat/skim milk, whole milk, yogurt and lactose intake has no associated with increased risk of ovarian cancer. Further studies with larger participants worldwide are needed to validate the association between dairy food intake and ovarian cancer.
authors.affiliation: a Lab of Molecular Genetics of Aging and Tumor, Faculty of Medicine , Kunming University of Science and Technology , Kunming , China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Wenru
authors.initials: W
authors.lastname: Tang
authors.forename: Lei
authors.initials: L
authors.lastname: Sang
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Dai
authors.forename: Danping
authors.initials: D
authors.lastname: Wei
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.forename: Jihong
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004032:Diet / Q000009:adverse effects*; D018752:Diet, Fat-Restricted / Q000009:adverse effects; D004040:Dietary Carbohydrates / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D007785:Lactose / Q000009:adverse effects* / Q000032:analysis; D008892:Milk / Q000009:adverse effects* / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D012306:Risk; D015014:Yogurt / Q000009:adverse effects* / Q000032:analysis
chemical_list: D004040:Dietary Carbohydrates; D007785:Lactose