title: Scientific rigor through videogames.
abstract: Hypothesis-driven experimentation - the scientific method - can be subverted by fraud, irreproducibility, and lack of rigorous predictive tests. A robust solution to these problems may be the 'massive open laboratory' model, recently embodied in the internet-scale videogame EteRNA. Deploying similar platforms throughout biology could enforce the scientific method more broadly.
authors.affiliation: Computer Science Department, Carnegie Mellon University, Pittsburgh, PA 15206, USA. Electronic address: treuille@cs.cmu.edu.
authors.forename: Adrien
authors.initials: A
authors.lastname: Treuille
authors.affiliation: Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Department of Physics, Stanford University, Stanford, CA 94305, USA. Electronic address: rhiju@stanford.edu.
authors.forename: Rhiju
authors.initials: R
authors.lastname: Das
mesh_terms: D019295:Computational Biology / Q000379:methods*; D008967:Molecular Biology / Q000295:instrumentation / Q000379:methods; D012313:RNA / Q000737:chemistry* / Q000235:genetics; D059370:RNA Folding; D014584:User-Computer Interface; D018910:Video Games
chemical_list: D012313:RNA
keywords: RNA design; crowdsourcing; high-throughput experiments; reproducibility; transparency; videogame