title: [Association between early life exposure to famine and damaging the liver and kidney function].
abstract: OBJECTIVE
  To examine how early life exposure to famine would impact on liver and kidney functions and related chronic metabolic diseases during adulthood.
  
  
  METHODS
  A random cluster sampling method was adopted in Anhui province, 2011 from a physical examination center, in a first-class hospital. 4 252 study subjects were born between 1957 and 1963. According to the time of birth:the study subjects were divided into three groups, respectively: 1957-1958 (983 persons as pre-famine), 1959-1961 (1 247 persons as exposed to famine) or 1962-1963(2 022 persons as controls, also the post-famine). Variances between groups AST, ALT, r-GGT, differences in the levels of SCr, UA, UREA and the change trend were compared.
  
  
  RESULTS
  ALT,IBIL, TBIL, SCr, UREA were statistically different (P < 0.05) among subjects born in the different years. r-GGT, ALT, AST, ALB, SCr were statistically different (P < 0.05) among males born in different years so as the r-GGT, AST, ALB, GLB, TP, SCr, UA, UREA in females (P < 0.05). r-GGT, ALT, ALB, SCr differences statistically significant (P < 0.05) and r-GGT, AST, ALB, GLB, TP, SCr, UA, UREA in females were statistically significantly different (P < 0.05).
  
  
  CONCLUSIONS
  Early life poor nutrition could lead to developmental disorders, organ function damage in liver and kidney function during adulthood. Women appeared to have balanced diet nutrition during pregnancy which was far important in the prevention on adulthood chronic metabolic diseases.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China.
authors.forename: Yuanbi
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Ye
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Nutrition, the First Affiliated Hospital of Bengbu Medical College.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China. Email: li1964li@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University, Hefei 230601, China.
authors.forename: Qihong
authors.initials: Q
authors.lastname: Zhao
mesh_terms: D002648:Child; D015362:Child Nutrition Disorders / Q000453:epidemiology*; D002681:China; D005260:Female; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000453:epidemiology*; D007668:Kidney / Q000503:physiopathology*; D008099:Liver / Q000503:physiopathology*; D008297:Male; D018811:Maternal Exposure; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013217:Starvation