title: Excess non-psychiatric hospitalizations among employees with mental disorders: a 10-year prospective study of the GAZEL cohort.
abstract: OBJECTIVE
  To examine whether non-psychiatric hospitalizations rates were higher in those with mental disorders.
  
  
  METHODS
  In a cohort of 15,811 employees, aged 35-50 years in 1989, mental disorder status was defined from 1989 to 2000. Hospitalizations for all-causes, myocardial infarction (MI), stroke, and cancer, were recorded yearly from 2001 to 2011. Negative binomial regression models were used to estimate hospitalization rates over the follow-up.
  
  
  RESULTS
  After controlling for baseline sociodemographic factors, health-related behaviors, self-rated health, and self-reported medical conditions, participants with a mental disorder had significantly higher rates of all-cause hospitalization [incidence rate ratio, IRR=1.20 (95%, 1.14-1.26)], as well as hospitalization due to MI [IRR=1.44 (95%, 1.12-1.85)]. For stroke, the IRR did not reach statistical significance [IRR=1.37 (95%, 0.95-1.99)] and there was no association with cancer [IRR=1.01 (95%, 0.86-1.19)]. A similar trend was observed when mental disorders groups were considered (no mental disorder, depressive disorder, mental disorders due to psychoactive substance use, other mental disorders, mixed mental disorders, and severe mental disorder).
  
  
  CONCLUSIONS
  In this prospective cohort of employees with stable employment as well as universal access to healthcare, we found participants with mental disorders to have higher rates of non-psychiatric hospitalizations.
authors.affiliation: Centre for Research in Epidemiology and Population Health, Epidemiology of Occupational and Social Determinants of Health, INSERM U1018, Villejuif, France; Université de Versailles St Quentin, Villejuif, France.
authors.forename: M
authors.initials: M
authors.lastname: Azevedo Da Silva
authors.forename: C
authors.initials: C
authors.lastname: Lemogne
authors.forename: M
authors.initials: M
authors.lastname: Melchior
authors.forename: M
authors.initials: M
authors.lastname: Zins
authors.forename: J
authors.initials: J
authors.lastname: Van Der Waerden
authors.forename: S M
authors.initials: SM
authors.lastname: Consoli
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: A
authors.initials: A
authors.lastname: Elbaz
authors.forename: A
authors.initials: A
authors.lastname: Singh-Manoux
authors.forename: H
authors.initials: H
authors.lastname: Nabi
mesh_terms: D000328:Adult; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D009786:Occupational Health Services; D011446:Prospective Studies; D012307:Risk Factors; D012959:Socioeconomic Factors; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology
keywords: chronic disease; healthcare; hospitalizations; mental disorders; prospective study