title: Visible-light-induced CO release from a therapeutically viable tryptophan-derived manganese(I) carbonyl (TryptoCORM) exhibiting potent inhibition against E. coli.
abstract: The first visible-light-activated carbon-monoxide-releasing molecule (CO-RM) to exhibit a potent effect against Escherichia coli is described. The easily prepared tryptophan-derived manganese-containing complex (TryptoCORM) released 1.4 moles of CO at 465 nm, and 2 moles at 400 nm. A comprehensive synthetic, mechanistic and microbiological study into the behaviour of TryptoCORM is reported. The complex is thermally stable (i.e., does not release CO in solution in the absence of light), shows low toxicity against mammalian cells and releases tryptophan on photoinduced degradation, all of which point to TryptoCORM being therapeutically viable.
authors.affiliation: Department of Chemistry, University of York, York (UK), Fax: (+44) 1904-322516; Centre for Immunology and Infection, Department of Biology, University of York, York (UK).
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Ward
authors.forename: Jason M
authors.initials: JM
authors.lastname: Lynam
authors.forename: James
authors.initials: J
authors.lastname: Moir
authors.forename: Ian J S
authors.initials: IJ
authors.lastname: Fairlamb
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002248:Carbon Monoxide / Q000008:administration & dosage*; D002460:Cell Line; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy; D006801:Humans; D008027:Light; D008345:Manganese / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D008345:Manganese; D002248:Carbon Monoxide; D014364:Tryptophan
keywords: carbon monoxide; circular dichroism; kinetics; photochemistry