title: Alteration of glucose lowering effect of glibenclamide on single and multiple treatments with fenofibrate in experimental rats and rabbit models.
abstract: OBJECTIVE
  Diabetes mellitus is a syndrome of multiple etiologies. Both type 1 and type 2 diabetes lead to multiple abnormalities of lipid and lipoprotein metabolism. The aim of this investigation was to study the influence of fenofibrate on the blood glucose lowering effect of glibenclamide.
  
  
  METHODS
  Glibenclamide (0.45, 0.23 mg/kg) and fenofibrate (18.1, 9.38 mg/kg) was treated to normal, diabetic rats, and normal rabbits. Blood samples were collected at various time intervals and were analyzed for blood glucose levels using a glucometer.
  
  
  RESULTS
  Co-administration of fenofibrate with glibenclamide significantly elevated the blood glucose reduction exhibited by glibenclamide.
  
  
  CONCLUSIONS
  The results obtained from single and multiple dose treatments clearly demonstrated the existence of drug-drug interaction at the dose tested in animal models. Hence, this investigation would serve as a preclinical evidence for the effect of fenofibrate on the therapeutic efficacy of glibenclamide.
authors.affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors.forename: Mayuren
authors.initials: M
authors.lastname: Candasamy
authors.affiliation: Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
authors.forename: Talasila Eswara Gopala Krishna
authors.initials: TE
authors.lastname: Murthy
authors.affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors.forename: Kumar Shiva
authors.initials: KS
authors.lastname: Gubiyappa
authors.affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors.forename: Dinesh Kumar
authors.initials: DK
authors.lastname: Chellappan
authors.affiliation: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Gupta
keywords: Blood glucose; diabetes; drug interaction