title: Immediate fat grafting in primary cleft lip repair.
abstract: BACKGROUND
  Successful cleft lip repair creates symmetric nasolabial morphology with minimal scar. Fat grafting is used in cosmetic and reconstructive settings to provide contour, condition tissue and aid healing. This study employs immediate fat grafting concurrent with primary cleft nasolabial repair. We hypothesize that simultaneous fat transfer is safe and may optimize the result.
  
  
  METHODS
  This retrospective analysis included a series of consecutive infants who underwent primary cleft lip repair with immediate fat grafting. Demographic and peri-operative details were recorded. Post-operative photographs were analyzed by three blinded reviewers (Al-Omari et al. and Asher-McDade et al.). Kappa statistics were employed to assess inter-rater reliability (Randolph and Watkins MW).
  
  
  RESULTS
  30 children, 37 sides (13 left, 10 right, 7 bilateral; 62% complete, 38% incomplete) who underwent cleft lip repair at Yale were included. 20 underwent nasolabial repair with simultaneous fat grafting. Mean age of repair was 3.5 mo (range 1.5-6.4). Fat was hand suctioned from the thighs (15 left; 2 right; 3 both) with mean yield of 2.1 cc (range 1-5 cc). An average of 1.4 cc (range 0.5-2.5 cc) was injected to the philtrum, vermillion, piriform and ala. No complications were experienced with lip repair, fat harvest or graft injection. Mean follow-up was 24.7 months (range 12.4-60.2 months). Postoperative photographic assessment revealed minimal residual cleft stigmata with inter-rater reliability. Each ordinal score was statistically significant compared fat grafted repairs to those without fat grafting (p < 0.05).
  
  
  CONCLUSIONS
  Simultaneous fat grafting and cleft lip repair can be performed safely. The augmentation and modulation of scar formation may optimize results. Prospective comparison is necessary to further corroborate our findings.
  
  
  METHODS
  Therapeutic (Level IV).
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA; Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Balkin
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA; Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Salem
authors.initials: S
authors.lastname: Samra
authors.affiliation: Yale University School of Medicine, New Haven, CT, USA; Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, USA. Electronic address: derek.steinbacher@yale.edu.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Steinbacher
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D002971:Cleft Lip / Q000601:surgery*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
keywords: Adipose-derived stem cells; Cleft lip; Fat graft; Scar; Wound healing