title: [Contemporary view on the role of bacteriophages in evolution of nosocomial strains and prophylaxis of healthcare associated infections].
abstract: One of the actual problems of contemporary healthcare are healthcare associated infections (HAI). An important aspect of study of HAI problem is the study of evolution of hospital strains causing HAI. The knowledge accumulated to date in the field of bacteria genetics gives evidence on the significant role of phages in the mechanism of virulence obtaining by pathogenic and opportunistic microorganisms. The studies of the authors of this article show that bacteriophages may play a significant role in the formation of virulent properties in hospital conditions that in different hospitals with participation of phages form virulent and antibiotic resistant hospital strains of HAI causative agents. At the same time bacteriophages are effective means for HAI therapy and prophylaxis. Under the condition of mass and irrational use of antibiotics, HAI causative agents form multiple resistance to the existing antibacterial preparations. In this regard bacteriophages as antimicrobial agents become especially actual. To date in Russian and foreign literature considerable material has been accumulated that shows high effectiveness of bacteriophages under the conditions of rational use. The aim of this review is to evaluate contemporary achievements in the field of study of bacteriophage role in evolution of hospital strains and therapy and prophylaxis of healthcare associated infections.
authors.forename: L P
authors.initials: LP
authors.lastname: Zueva
authors.forename: B I
authors.initials: BI
authors.lastname: Aslanov
authors.forename: V G
authors.initials: VG
authors.lastname: Akimkin
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000235:genetics / Q000472:pathogenicity; D001435:Bacteriophages / Q000235:genetics* / Q000472:pathogenicity; D005075:Biological Evolution; D003428:Cross Infection / Q000209:etiology / Q000235:genetics* / Q000382:microbiology* / Q000517:prevention & control; D004352:Drug Resistance, Microbial / Q000235:genetics; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents