title: Malignant peripheral nerve sheath tumor of the vulva, an unusual differential diagnosis for vulvar mass.
abstract: BACKGROUND
  Malignant peripheral nerve sheath tumors (MPNSTs) are rare, up to one half of the MPNSTs occur in patients with neurofibromatosis type-1 (NF-1), while the rest are sporadic. Here, we present a 52-year-old woman with MPNST of the vulva without NF-1. We will discuss basics of the disease, treatment options and follow-up strategies.
  
  
  METHODS
  52-year-old female admitted to our hospital with complaint of abnormal uterine bleeding and rapidly growing vulvar mass. Excisional biopsy of the mass showed MPNST of the vulva. Afterwards, the patient underwent radical vulvectomy with inguinofemoral lymph node dissection. Short after the surgery, multiple lung metastasis were shown and responded to chemotherapy, but rapid local recurrence occurred short after the completion of the chemotherapy.
  
  
  CONCLUSIONS
  The primary treatment option in MPNSTs is surgical excision with or without adjuvant therapy. There is not enough data about the role of systemic chemotherapy in the management of MPNSTs and it still remains controversial.
  
  
  CONCLUSIONS
  In general, radiation therapy has not been demonstrated to improve overall survival. Complete surgical resection of the primary tumor is the mainstay of the treatment.
authors.affiliation: Department of Gynecological Oncology, Zekai Tahir Burak Women's Health Hospital, Ankara, Turkey. Electronic address: bulentozdal@gmail.com.
authors.forename: Bülent
authors.initials: B
authors.lastname: Ozdal
authors.affiliation: Department of Gynecological Oncology, Zekai Tahir Burak Women's Health Hospital, Ankara, Turkey. Electronic address: ozmurat@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Oz
authors.affiliation: Department of Gynecological Oncology, Zekai Tahir Burak Women's Health Hospital, Ankara, Turkey. Electronic address: elmas.korkmaz@hotmail.com.
authors.forename: Elmas
authors.initials: E
authors.lastname: Korkmaz
authors.affiliation: Department of Pathology, Mikro-pat, Ankara, Turkey. Electronic address: info@mikropat.com.tr.
authors.forename: Omür
authors.initials: O
authors.lastname: Ataoğlu
authors.affiliation: Department of Gynecological Oncology, Zekai Tahir Burak Women's Health Hospital, Ankara, Turkey. Electronic address: gungortayfun@yahoo.com.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Güngör
authors.affiliation: Department of Gynecological Oncology, Zekai Tahir Burak Women's Health Hospital, Ankara, Turkey. Electronic address: mmmeydanli@gmail.com.
authors.forename: Mehmet Mutlu
authors.initials: MM
authors.lastname: Meydanli
keywords: MPNST; Malignant schwannoma; Vulvar cancer