title: The function of nicotinamide phosphoribosyltransferase in the heart.
abstract: In addition to its roles as a coenzyme and an electron transfer molecule, nicotinamide adenine dinucleotide (NAD+) has emerged as a substrate of sirtuins, a family of enzymes that control aging and metabolism. Nicotinamide phosphoribosyltransferase (Nampt), a rate-limiting enzyme in the NAD+ salvage pathway, plays an important role in controlling the level of NAD+ and the activity of Sirt1 in the heart and the cardiomyocytes therein. Nampt protects the heart from ischemia and reperfusion injury by stimulating Sirt1. In this review, we summarize what is currently known regarding the function of Nampt in the heart.
authors.affiliation: Division of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC.
authors.forename: Chiao-Po
authors.initials: CP
authors.lastname: Hsu
authors.affiliation: Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers - New Jersey Medical School, Newark, NJ, USA.
authors.forename: Takanobu
authors.initials: T
authors.lastname: Yamamoto
authors.affiliation: Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers - New Jersey Medical School, Newark, NJ, USA.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.affiliation: Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, Rutgers - New Jersey Medical School, Newark, NJ, USA. Electronic address: Sadoshju@njms.rutgers.edu.
authors.forename: Junichi
authors.initials: J
authors.lastname: Sadoshima
mesh_terms: D000818:Animals; D001343:Autophagy; D006332:Cardiomegaly / Q000201:enzymology / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D008822:Mice, Transgenic; D017202:Myocardial Ischemia / Q000201:enzymology; D015428:Myocardial Reperfusion Injury / Q000201:enzymology / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D054409:Nicotinamide Phosphoribosyltransferase / Q000235:genetics / Q000378:metabolism*
chemical_list: D054409:Nicotinamide Phosphoribosyltransferase
keywords: Apoptosis; Heart; Ischemia; NAD+; Reperfusion; Sirt1