title: Predictors of mortality in children with typhoid ileal perforation in a Nigerian tertiary hospital.
abstract: OBJECTIVE
  Childhood typhoid ileal perforation is associated with high morbidity and mortality. Our aim was to ascertain the predictors of survival in children.
  
  
  METHODS
  This is a tertiary hospital-based retrospective review of patients aged ≤15 years managed for typhoid ileal perforations between January 2005 and December 2013. The details of their biodata, potential risk factors and outcome were evaluated.
  
  
  RESULTS
  Forty-five children out of a total of 97 with typhoid fever had typhoid ileal perforation. The age range was 2-15 years, mean (±SD) = 9.3 (±3.31) years, median = 10 years. There were more males than females (26:19). Thirty-nine (86.7%) patients were >5 years old. There were nine deaths (20% mortality). The mean (±SD) age of survivors was 9.8 (±2.9) years and 7.1 (±4.2) for non-survivors (p = 0.026). The duration of illness at presentation, gender, admission temperature, nutritional status and packed cell volume, perforation-operation interval, number of perforations, surgical procedure, and the duration of surgery did not statistically influence survival (p > 0.05). The age of the patients and burst abdomen attained statistical significance (p < 0.05).
  
  
  CONCLUSIONS
  The patients' age and postoperative burst abdomen were significant determinants of survival in children with typhoid ileal perforation.
authors.affiliation: Obafemi Awolowo University, Teaching Hospitals Complex, Ile-Ife, Osun, Nigeria, ademolatalabi1608@gmail.com.
authors.forename: Ademola Olusegun
authors.initials: AO
authors.lastname: Talabi
authors.forename: Amarachukwu Chiduziem
authors.initials: AC
authors.lastname: Etonyeaku
authors.forename: Oludayo Adedapo
authors.initials: OA
authors.lastname: Sowande
authors.forename: Samuel Anu
authors.initials: SA
authors.lastname: Olowookere
authors.forename: Olusanya
authors.initials: O
authors.lastname: Adejuyigbe
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007077:Ileal Diseases / Q000401:mortality* / Q000601:surgery; D007416:Intestinal Perforation / Q000401:mortality* / Q000601:surgery; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D011183:Postoperative Complications / Q000401:mortality* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D062606:Tertiary Care Centers / Q000706:statistics & numerical data*; D014435:Typhoid Fever / Q000401:mortality*