title: CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast.
abstract: BACKGROUND
  Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma.
  
  
  RESULTS
  Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2.
  
  
  CONCLUSIONS
  These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. hslaura@hotmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: García-Labastida
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. rgguajardo@yahoo.com.
authors.forename: Raquel
authors.initials: R
authors.lastname: Garza-Guajardo
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. oralibarboza@gmail.com.
authors.forename: Oralia
authors.initials: O
authors.lastname: Barboza-Quintana
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. iramrodriguez@gmail.com.
authors.forename: Irám Pablo
authors.initials: IP
authors.lastname: Rodríguez-Sanchez
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. jesus.ancer@uanl.mx.
authors.forename: Jesús
authors.initials: J
authors.lastname: Ancer-Rodríguez
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. jufloresmx@hotmail.com.
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Flores-Gutierrez
authors.affiliation: Universidad Autónoma de Nuevo León, Hospital Universitario "Dr. José Eleuterio González", Departamento de Anatomía Patológica y Citopatología, Madero and Gonzalitos S/N, Col. Mitras Centro, Monterrey, Nuevo Leon, 64460, Mexico. bpositivo66@hotmail.com.
authors.forename: Gabriela Sofía
authors.initials: GS
authors.lastname: Gómez-Macías
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000943:Antigens, Differentiation / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D000071616:CDX2 Transcription Factor; D005260:Female; D018398:Homeodomain Proteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry*; D008875:Middle Aged; D055262:Mucin-2 / Q000032:analysis*; D012189:Retrospective Studies; D015534:Trans-Activators / Q000032:analysis*; D051176:beta Catenin / Q000032:analysis*
chemical_list: D000943:Antigens, Differentiation; D014408:Biomarkers, Tumor; D000071616:CDX2 Transcription Factor; D018398:Homeodomain Proteins; C524625:MUC2 protein, human; D055262:Mucin-2; D015534:Trans-Activators; D051176:beta Catenin