title: [Quantitative cellular metabolism can be estimated by hyperpolarized magnetic resonance].
abstract: A new MR methodology, hyperpolarized MR spectroscopy (MRS), enhances the MRS signals by more than a factor 10,000, enabling fast and unique insight into in situ metabolic processes. So far the method has provided new and exciting metabolic details in prostate, heart, brain, kidney and liver examinations. In diseases characterized by abnormal metabolic profiles, such as in diabetes and tumour tissue, hyperpolarized MRS provides highly detailed spatial information as well as quantitative estimates of individual steps in glycolysis and real-time amino acid metabolism.
authors.affiliation: MR Centret, Institut for Klinisk Medicin, Aarhus Universitet, Brendstrupgaardsvej 100, 8200 Aarhus. hsj@mr.au.dk.
authors.forename: Christoffer
authors.initials: C
authors.lastname: Laustsen
authors.forename: Jan Henrik
authors.initials: JH
authors.lastname: Ardenkjaer-Larsen
authors.forename: Michael
authors.initials: M
authors.lastname: Pedersen
authors.forename: Steffen
authors.initials: S
authors.lastname: Ringgaard
authors.forename: Hans
authors.initials: H
authors.lastname: Stødkilde-Jørgensen
mesh_terms: D061605:Administration, Intravenous; D015374:Biosensing Techniques; D006801:Humans; D019344:Lactic Acid / Q000008:administration & dosage / Q000378:metabolism; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000378:metabolism; D019289:Pyruvic Acid / Q000008:administration & dosage / Q000378:metabolism
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid