title: Adipose derived stem cells: basic science fundaments and clinical application. An update.
abstract: Soft tissues regeneration can be used to treat several kinds of diseases including congenital and post traumatic deformities, and to fill out tissue depression due to orbital and periorbital surgery, scars or cancer resections. Generally it is performed by the use of autologous tissue flaps, alloplastic implants and autologous fat grafting. All of these methods have several disadvantages, which include resorption of the autologous material, foreign body reaction and implant migration. Stem cell application has been suggested as a possible novel therapy for regenerative medicine thanks to their unlimited capacity of self-renewal, as well as the property to differentiate into multiple cell types under appropriate stimuli. This short review describe the recent development in stem cells isolation, expansion and characterization and their employment in tissue regeneration and tissue engineering.
authors.affiliation: Department of Interdisciplinary Surgery and Medicine University Milano Bicocca, Milan, Italy - dorina.lauritano@unimib.it.
authors.forename: D
authors.initials: D
authors.lastname: Lauritano
authors.forename: A
authors.initials: A
authors.lastname: Palmieri
authors.forename: R
authors.initials: R
authors.lastname: Vinci
authors.forename: L
authors.initials: L
authors.lastname: Azzi
authors.forename: A
authors.initials: A
authors.lastname: Taglabue
authors.forename: F
authors.initials: F
authors.lastname: Carinci
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D000818:Animals; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000378:metabolism; D048091:Guided Tissue Regeneration / Q000379:methods*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007558:Italy; D057905:Stem Cell Research / Q000941:ethics / Q000331:legislation & jurisprudence; D023822:Tissue Engineering / Q000379:methods*; D014182:Transplantation, Autologous; D014945:Wound Healing
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins