title: Bioactive clerodane diterpenoids from the twigs of Casearia balansae.
abstract: Eight new clerodane diterpenes, balanspenes A-H (1-8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae. The structures of 1-8 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of compounds 1, 4, and 7 were confirmed by comparing their experimental CD spectra with those calculated by the time-dependent density functional theory method. Compounds 4-7, 9, and 10 were found to possess the property of being able to stimulate NGF-mediated neurite outgrowth from PC12 cells.
authors.affiliation: State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, ‡Tianjin Key Laboratory of Molecular Drug Research, and ⊥School of Medicine, Nankai University , Tianjin 300071, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Meicheng
authors.initials: M
authors.lastname: Wang
authors.forename: Quanhui
authors.initials: Q
authors.lastname: Ren
authors.forename: Yihang
authors.initials: Y
authors.lastname: Sun
authors.forename: Da-Qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Hongqiang
authors.initials: H
authors.lastname: Chen
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D037821:Casearia / Q000737:chemistry*; D002942:Circular Dichroism; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; D020932:Nerve Growth Factor