title: Volumetric-modulated arc therapy for oropharyngeal carcinoma: a dosimetric and delivery efficiency comparison with static-field IMRT.
abstract: The purpose of this study is to evaluate the treatment plan adequacy and delivery efficiency among volumetric-modulated arc therapy (VMAT) with one or two arcs and the conventional static-field dynamic multileaf collimator (dMLC) intensity-modulated radiation therapy (IMRT) in patients undergoing oropharyngeal carcinoma. Fifteen patient cases were included in this investigation. Each of the cases was planned using step-and-shoot IMRT, VMAT with a single arc (Arc1) and VMAT with double arcs (Arc2). A two-dose level prescription for planning target volumes (PTVs) was delivered with 70 Gy/56 Gy in 30 fractions. Comparisons were performed of the dose-volume histograms (DVH) for PTVs, the DVH for organs at risk (OARs), the monitor units per fraction (MU/fx), and delivery time. IMRT and Arc2 achieved similar target coverage, but superior to Arc1. Apart from the oral cavity, Arc1 showed no advantage in sparing of OARs compared with IMRT, while Arc2 obtained equivalent or better sparing of OARs among the three techniques. VMAT reduced MU/fx and shortened delivery time remarkably compared with IMRT. Our results demonstrated that for oropharyngeal cases, Arc2 can achieve superior target coverage and normal tissue sparing, as well as a significant reduction in treatment time.
authors.affiliation: Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Dai
authors.affiliation: Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Yingchao
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Zhiwen
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Cancer Center, Union Hospital, Huazhong University of Sciences and Technology, Wuhan, China.
authors.forename: Meera
authors.initials: M
authors.lastname: Dassarath
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: Lihui
authors.initials: L
authors.lastname: Jin
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: James
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Price
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Electronic address: Charlie.ma@fccc.edu.
authors.forename: C-M
authors.initials: CM
authors.lastname: Ma
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D006801:Humans; D058958:Organs at Risk / Q000528:radiation effects; D009959:Oropharyngeal Neoplasms / Q000532:radiotherapy*; D011874:Radiometry; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects / Q000379:methods*; D013997:Time Factors
keywords: IMRT; Intensity-modulated radiation therapy; Oropharyngeal carcinoma; Radiotherapy; VMAT; Volumetric-modulated arc therapy