title: Do lamin A and lamin C have unique roles?
abstract: The A-type lamins, lamin A and lamin C, generated from a single gene, LMNA, are major structural components of the nuclear lamina. The two alternative splice products have mostly been studied together because they have been considered to be interchangeable. However, several lines of evidence indicate that in spite of being generated from the same gene and having high similarities in their primary sequences, the two isoforms are not equivalent in different biological aspects in both health and disease. The key question is whether they have both overlapping and unique functions and whether they are distinctly regulated. Based on the so far available experimental evidence, lamin A appears to be the most regulated A-type isoform during development, aging, and disease which indicates that lamin A is implicated in many different biological aspects and may have a greater repertoire of specialized functions than lamin C. The aim of this review is to point out differences between the two major LMNA splice variants and the consequences of these differences on their functions. This may guide further research and be of prime importance for the understanding of the pathogenesis of LMNA mutations.
authors.affiliation: Research Unit for Molecular Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark, RASHA.AL-SAAIDI@KI.AU.DK.
authors.forename: Rasha
authors.initials: R
authors.lastname: Al-Saaidi
authors.forename: Peter
authors.initials: P
authors.lastname: Bross
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D006801:Humans; D034904:Lamin Type A / Q000235:genetics* / Q000502:physiology; D051379:Mice; D009154:Mutation; D020033:Protein Isoforms / Q000235:genetics / Q000502:physiology
chemical_list: C494847:LMNA protein, human; D034904:Lamin Type A; C576142:Lmna protein, mouse; D020033:Protein Isoforms