title: New antibacterial xanthone from the marine sponge-derived Micrococcus sp. EG45.
abstract: Microluside A [4 (19-para-hydroxy benzoyloxy-O-β-D-cellobiosyl), 5 (30-para-hydroxy benzoyloxy-O-β-D-glucopyranosyl) xanthone (1)] is a unique O-glycosylated disubstituted xanthone isolated from the broth culture of Micrococcus sp. EG45 cultivated from the Red Sea sponge Spheciospongia vagabunda. The structure of microluside A was determined by 1D- and 2D-NMR techniques as well as high resolution tandem mass spectrometry. The antimicrobial activity evaluation showed that 1 exhibited antibacterial potential against Enterococcus faecalis JH212 and Staphylococcus aureus NCTC 8325 with MIC values of 10 and 13 μM, respectively.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
authors.forename: Enas E
authors.initials: EE
authors.lastname: Eltamany
authors.affiliation: Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, D-97082 Würzburg, Germany.
authors.forename: Usama Ramadan
authors.initials: UR
authors.lastname: Abdelmohsen
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
authors.forename: Amany K
authors.initials: AK
authors.lastname: Ibrahim
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
authors.forename: Hashim A
authors.initials: HA
authors.lastname: Hassanean
authors.affiliation: Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, D-97082 Würzburg, Germany.
authors.forename: Ute
authors.initials: U
authors.lastname: Hentschel
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. Electronic address: safwat_aa@yahoo.com.
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008837:Micrococcus / Q000187:drug effects*; D011161:Porifera / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects*; D053719:Tandem Mass Spectrometry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000900:Anti-Bacterial Agents; D044004:Xanthones; C009689:xanthone
keywords: Actinomycetes; Antimicrobial activity; Micrococcus sp.; Spheciospongia vagabunda; Xanthone