title: Treatment-related problems experienced by cancer patients undergoing chemotherapy: a scoping review.
abstract: Cancer patients undergoing chemotherapy experience a range of treatment-related problems, and variations in prevalence exist between treatment centres. A scoping review was undertaken to map reported rates of problem prevalence in the literature. This will inform development of a patient-reported outcome measure (PROM) to monitor prevalence and severity of problems over time and assist service providers optimise supportive care provision. Two databases (Embase and Medline) were searched from 2002 to 2013. Fifty one published papers and conference abstracts reporting problem prevalence rates were identified. The papers reported 98 different problems, from which a typology of 27 problem domains was developed, including both physical symptoms and psychosocial issues. The problem domains most often studied were nausea, vomiting and fatigue. This review reflects the chemotherapy-associated problems to which researchers attach the most importance. The range in reported prevalence across studies was very broad (e.g. nausea: 9-74%), with even less frequently studied problems showing high prevalence in some studies (e.g. gynaecological problems: up to 94%). The wide variation in prevalence and range of problems experienced raises challenges for PROM development. Patients should therefore be involved in consensus exercises to assist selection of items to ensure any instrument is complete and robust.
authors.affiliation: Faculty of Health Sciences, Highfield, University of Southampton, Southampton, UK.
authors.forename: R
authors.initials: R
authors.lastname: Wagland
authors.affiliation: Faculty of Health Science, Southampton General Hospital, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, UK.
authors.forename: A
authors.initials: A
authors.lastname: Richardson
authors.affiliation: Florence Nightingale School of Nursing & Midwifery King's College London, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Armes
authors.affiliation: Centre for Innovation and Leadership in Health Sciences, Faculty of Health Sciences, University of Southampton, Southampton, UK.
authors.forename: M
authors.initials: M
authors.lastname: Hankins
authors.affiliation: University Hospital Southampton, Southampton, UK.
authors.forename: E
authors.initials: E
authors.lastname: Lennan
authors.affiliation: Centre for Innovation and Leadership in Health Sciences, Faculty of Health Sciences, Highfield, University of Southampton, Southampton, UK.
authors.forename: P
authors.initials: P
authors.lastname: Griffiths
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D003072:Cognition Disorders / Q000209:etiology; D003362:Cost-Benefit Analysis; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology; D009325:Nausea / Q000453:epidemiology / Q000209:etiology; D009369:Neoplasms / Q000188:drug therapy*; D015995:Prevalence; D012678:Sensation Disorders / Q000453:epidemiology / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents
keywords: cancer; chemotherapy; quality of life; supportive care; symptoms