title: A preclinical murine model of hepatic metastases.
abstract: Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Soares
authors.affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine.
authors.forename: Kelly
authors.initials: K
authors.lastname: Foley
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine.
authors.forename: Kelly
authors.initials: K
authors.lastname: Olino
authors.affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine.
authors.forename: Ashley
authors.initials: A
authors.lastname: Leubner
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine.
authors.forename: Skye C
authors.initials: SC
authors.lastname: Mayo
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine.
authors.forename: Ajay
authors.initials: A
authors.lastname: Jain
authors.affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Jaffee
authors.affiliation: Department of Surgery, University of Colorado Anschutz Medical Campus.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Schulick
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine.
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshimura
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine; Barish.Edil@UCDenver.edu.
authors.forename: Barish
authors.initials: B
authors.lastname: Edil
authors.affiliation: Department of Surgery, The Johns Hopkins University School of Medicine; Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine; Lzheng6@jhmi.edu.
authors.forename: Lei
authors.initials: L
authors.lastname: Zheng
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000473:pathology*