title: Antimicrobial resistance investigation on Staphylococcus strains in a local hospital in Guangzhou, China, 2001-2010.
abstract: A retrospective study was conducted on 1,739 Staphylococcus isolates from the First Affiliated Hospital of Jinan University (FAHJU) in Guangzhou during 2001-2010. With the exception of teicoplanin and vancomycin, antimicrobial resistance was commonly observed among the isolates examined, with high resistance rates for β-lactamases (94.0% and 73.7% for penicillin and oxacillin) and resistance percentages for cefoxitin, chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and tetracycline ranging from 83.9% to 19.4%. Two hundred sixty-three of the 1,739 isolates were subjected to SCCmec typing and 42 to MLST, spaA, and coa typing. ST239-MRSA-III was prevalently identified along with one distinct coa type HIJKL and 2 spaA types (WGKAOMQ-t037 and WGKAQQ-t030). Class 1 integrons were commonly detected (31.6%), although none of the integron-positive MRSA strains had been isolated since 2009. The widespread detection of integron-based antimicrobial resistance determinants may further contribute to the emergence of superbugs.
authors.affiliation: 1 College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China .
authors.forename: Yang
authors.initials: Y
authors.lastname: Deng
authors.forename: Junyan
authors.initials: J
authors.lastname: Liu
authors.forename: Brian M
authors.initials: BM
authors.lastname: Peters
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Miao
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Dingqiang
authors.initials: D
authors.lastname: Chen
authors.forename: Guangchao
authors.initials: G
authors.lastname: Yu
authors.forename: Zhenbo
authors.initials: Z
authors.lastname: Xu
authors.forename: Mark E
authors.initials: ME
authors.lastname: Shirtliff
mesh_terms: D002681:China / Q000453:epidemiology; D052978:Disk Diffusion Antimicrobial Tests; D024901:Drug Resistance, Multiple, Bacterial; D006786:Hospitals, Urban; D006801:Humans; D032023:Integrons / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification