title: Potentiality of the "Gum Metal" titanium-based alloy for biomedical applications.
abstract: In this study, the "Gum Metal" titanium-based alloy (Ti-23Nb-0.7Ta-2Zr-1.2O) was synthesized by melting and then characterized in order to evaluate its potential for biomedical applications. Thus, the mechanical properties, the corrosion resistance in simulated body fluid and the in vitro cell response were investigated. It was shown that this alloy presents a very high strength, a low Young's modulus and a high recoverable strain by comparison with the titanium alloys currently used in medicine. On the other hand, all electrochemical and corrosion parameters exhibited more favorable values showing a nobler behavior and negligible toxicity in comparison with the commercially pure Ti taken as reference. Furthermore, the biocompatibility tests showed that this alloy induced an excellent response of MC3T3-E1 pre-osteoblasts in terms of attachment, spreading, viability, proliferation and differentiation. Consequently, the "Gum Metal" titanium-based alloy processes useful characteristics for the manufacturing of highly biocompatible medical devices.
authors.affiliation: Institut des Sciences Chimiques de Rennes (UMR CNRS 6226), INSA Rennes, 20 Avenue des Buttes de Coësmes, F-35043 Rennes Cedex, France.
authors.forename: D M
authors.initials: DM
authors.lastname: Gordin
authors.affiliation: University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania.
authors.forename: R
authors.initials: R
authors.lastname: Ion
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: C
authors.initials: C
authors.lastname: Vasilescu
authors.affiliation: Institute of Physical Chemistry "Ilie Murgulescu" of Romanian Academy, Spl. Independentei 202, 060021 Bucharest, Romania.
authors.forename: S I
authors.initials: SI
authors.lastname: Drob
authors.affiliation: University of Bucharest, Department of Biochemistry and Molecular Biology, 91-95 Spl. Independentei, 050095 Bucharest, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Cimpean
authors.affiliation: Institut des Sciences Chimiques de Rennes (UMR CNRS 6226), INSA Rennes, 20 Avenue des Buttes de Coësmes, F-35043 Rennes Cedex, France. Electronic address: Thierry.Gloriant@insa-rennes.fr.
authors.forename: T
authors.initials: T
authors.lastname: Gloriant
mesh_terms: D041721:3T3-L1 Cells; D000497:Alloys / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001826:Body Fluids / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D055119:Elastic Modulus / Q000187:drug effects; D055664:Electrochemical Techniques; D008422:Materials Testing / Q000379:methods; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects; D014025:Titanium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D014025:Titanium
keywords: Biocorrosion; Cytocompatibility; Mechanical properties; Titanium alloy