title: Immunoregulatory T-cell defects.
abstract: In normal circumstances homeostatic balance is maintained between T-cell help and suppression. In this review Raif Geha and Fred Rosen discuss examples of human diseases which involve excess or deficiency of T-cell help or T-cell suppression - diseases which have contributed greatly to an understanding of how T cells regulate the human immune response.
authors.affiliation: Divisions of Allergy and Immunology, The Children's Hospital, and the Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Geha
authors.forename: F S
authors.initials: FS
authors.lastname: Rosen