title: Chemopreventive effects of (-)-hinokinin against 1,2-dimethylhydrazine-induced genotoxicity and preneoplastic lesions in rat colon.
abstract: (-)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (-)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4-5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay.
authors.affiliation: Universidade de Franca , Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, São Paulo, Brazil.
authors.forename: Lilian C
authors.initials: LC
authors.lastname: Barbosa
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Furtado
authors.forename: Humberto C C
authors.initials: HC
authors.lastname: Bertanha
authors.forename: Iara M
authors.initials: IM
authors.lastname: Tomazella
authors.forename: Eveline S
authors.initials: ES
authors.lastname: Costa
authors.forename: Jairo K
authors.initials: JK
authors.lastname: Bastos
authors.forename: Márcio L
authors.initials: ML
authors.lastname: Andrade e Silva
authors.forename: Denise C
authors.initials: DC
authors.lastname: Tavares
mesh_terms: D019813:1,2-Dimethylhydrazine / Q000494:pharmacology*; D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D052117:Benzodioxoles; D002273:Carcinogens / Q000494:pharmacology; D003106:Colon / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage / Q000187:drug effects; D004127:Dimethylhydrazines / Q000737:chemistry; D004149:Dioxoles / Q000737:chemistry / Q000494:pharmacology*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism
chemical_list: D016588:Anticarcinogenic Agents; D052117:Benzodioxoles; D002273:Carcinogens; D004127:Dimethylhydrazines; D004149:Dioxoles; D017705:Lignans; C475934:hinokinin; C013958:dimazine; D019813:1,2-Dimethylhydrazine; C433065:cubebin; D015107:4-Butyrolactone