title: Automated auditory brainstem response in preterm newborns with histological chorioamnionitis.
abstract: OBJECTIVE
  We investigated whether histological chorioamnionitis is associated with an adverse neonatal hearing outcome.
  
  
  METHODS
  Two cohorts of very preterm newborns (n = 548, gestational age ≤ 32.0 weeks) were linked to placental histology and automated auditory brainstem response (AABR) outcome.
  
  
  RESULTS
  In multivariable analyses, an abnormal AABR was not predicted by the presence of histological chorioamnionitis, either with or without fetal involvement (OR 1.4, 95% CI 0.5 - 3.8, p = 0.54 and OR 1.1, 95% CI 0.4-3.0, p = 0.79, respectively). Significant predictors of abnormal AABR included, e.g. birth weight (per kg increase: OR 0.2, 95% CI 0.0-0.6, p = 0.006), umbilical cord artery pH (per 0.1 increase: OR 0.7, 95% CI 0.5-0.9, p = 0.005) and mechanical ventilation (OR 3.7, 95% CI 1.2-11.6, p = 0.03).
  
  
  CONCLUSIONS
  Histological chorioamnionitis was not associated with an adverse neonatal hearing outcome in two cohorts of very preterm newborns. Indicators of a complicated neonatal clinical course were the most important predictors of an abnormal hearing screening.
authors.affiliation: a Department of Otorhinolaryngology/Head and Neck Surgery , Maastricht University Medical Centre , Maastricht , The Netherlands .
authors.forename: Adriana L
authors.initials: AL
authors.lastname: Smit
authors.forename: Jasper V
authors.initials: JV
authors.lastname: Been
authors.forename: Luc J I
authors.initials: LJ
authors.lastname: Zimmermann
authors.forename: Rene F
authors.initials: RF
authors.lastname: Kornelisse
authors.forename: Peter
authors.initials: P
authors.lastname: Andriessen
authors.forename: Sizzle F
authors.initials: SF
authors.lastname: Vanterpool
authors.forename: Martijn P H
authors.initials: MP
authors.lastname: Bischoff
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Stokroos
authors.forename: Ronald R
authors.initials: RR
authors.lastname: de Krijger
authors.forename: Bernd
authors.initials: B
authors.lastname: Kremer
authors.forename: Boris W
authors.initials: BW
authors.lastname: Kramer
mesh_terms: D000328:Adult; D002821:Chorioamnionitis / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D015331:Cohort Studies; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D017359:HELLP Syndrome / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D006311:Hearing Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D006320:Hearing Tests / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology / Q000503:physiopathology; D008297:Male; D015997:Neonatal Screening / Q000379:methods; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D055815:Young Adult
keywords: Automated auditory brainstem response; chorioamnionitis; hearing screening; preterm infants