title: Endometrial stem cell transplantation in MPTP- exposed primates: an alternative cell source for treatment of Parkinson's disease.
abstract: Parkinson's disease (PD) is a neurodegenerative disease caused by the loss of dopaminergic neurons in the substantia nigra. Cell-replacement therapies have emerged as a promising strategy to slow down or replace neuronal loss. Compared to other stem cell types, endometrium-derived stem cells (EDSCs) are an attractive source of stem cells for cellular therapies because of their ease of collection and vast differentiation potential. Here we demonstrate that endometrium-derived stem cells may be transplanted into an MPTP exposed monkey model of PD. After injection into the striatum, endometrium-derived stem cells engrafted, exhibited neuron-like morphology, expressed tyrosine hydroxylase (TH) and increased the numbers of TH positive cells on the transplanted side and dopamine metabolite concentrations in vivo. Our results suggest that endometrium-derived stem cells may provide a therapeutic benefit in the primate model of PD and may be used in stem cell based therapies.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Erin F
authors.initials: EF
authors.lastname: Wolff
authors.forename: Levent
authors.initials: L
authors.lastname: Mutlu
authors.forename: Efi E
authors.initials: EE
authors.lastname: Massasa
authors.forename: John D
authors.initials: JD
authors.lastname: Elsworth
authors.forename: D
authors.initials: D
authors.lastname: Eugene Redmond
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Taylor
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002452:Cell Count; D002465:Cell Movement; D004717:Endometrium / Q000166:cytology*; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000378:metabolism; D010300:Parkinson Disease / Q000473:pathology / Q000628:therapy*; D011323:Primates; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D014446:Tyrosine 3-Monooxygenase; D006719:Homovanillic Acid
keywords: MPTP; Parkinson disease; adult stem cells; endometrium; mesenchymal stem cells; neurodegenerative diseases; stem cells; transplantation