title: The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs.
abstract: To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Antita
authors.initials: A
authors.lastname: Adriaens
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Kathelijne
authors.initials: K
authors.lastname: Peremans
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Tim
authors.initials: T
authors.lastname: Waelbers
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Eva
authors.initials: E
authors.lastname: Vandermeulen
authors.affiliation: Department of Pharmacology, Biochemistry and Toxicology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
authors.affiliation: Department of Physiology and Biometry, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Luc
authors.initials: L
authors.lastname: Duchateau
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: André
authors.initials: A
authors.lastname: Dobbeleir
authors.affiliation: Department of Psychiatry and Medical Psychology, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
authors.forename: Kurt
authors.initials: K
authors.lastname: Audenaert
authors.affiliation: Nuclear Medicine and PET research, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Jos
authors.initials: J
authors.lastname: Eersels
authors.affiliation: Department of Medical Imaging of Domestic Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Simon
authors.initials: S
authors.lastname: Vermeire
authors.affiliation: Drug Quality & Registration (DruQuaR) group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
authors.forename: Bart
authors.initials: B
authors.lastname: De Spiegeleer
authors.affiliation: Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Ingeborgh
authors.initials: I
authors.lastname: Polis
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003545:Cysteine / Q000031:analogs & derivatives*; D004285:Dogs; D005260:Female; D009020:Morphine / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D015609:Organotechnetium Compounds; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D009020:Morphine; C059659:technetium Tc 99m bicisate; D003545:Cysteine