title: LOXL1 Gene Polymorphism With Exfoliation Syndrome/Exfoliation Glaucoma: A Meta-Analysis.
abstract: OBJECTIVE
  There were several studies that have researched the associations between lysyl oxidase-like 1 (LOXL1) gene polymorphism and the susceptibility to exfoliation syndrome (XFS)/exfoliation glaucoma (XFG), but results have been inconclusive.
  
  
  METHODS
  A meta-analysis was performed for deriving more exact estimation of the relationship. Twenty-five studies were selected for studying rs1048661 and rs3825942. Sixteen studies were selected for studying rs2165241.
  
  
  RESULTS
  Single nucleotide polymorphism (SNP) rs1048661 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be G, as opposite to the T allele in Japanese, Chinese, and Korean populations. The SNP rs3825942 was significantly associated with XFS in this black South African population. However, the AA genotype of rs3825942 confers XFS risk in this population, as opposed to the GG genotype described in all other populations. SNP rs2165241 was found to be associated with XFS/XFG, but the risk allele in white populations was found to be T, as opposite to the "C" allele in Japanese and Korean populations.
  
  
  CONCLUSIONS
  Our meta-analysis indicates that rs1048661 ("G" alleles) had weak association with XFG/XFS; rs3825942 ("G" alleles) had strongly association with XFG/XFS; and rs2165241("T" alleles) had significant risk with XFG/XFS in some ethnicity.
authors.affiliation: *Eye Hospital, The First Affiliated Hospital †Laboratory of Medical Genetics, Harbin Medical University, Harbin, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Yongbin
authors.initials: Y
authors.lastname: Yu
authors.forename: Songbin
authors.initials: S
authors.lastname: Fu
authors.forename: Wencheng
authors.initials: W
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D000483:Alleles; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D005006:Ethnicity; D017889:Exfoliation Syndrome / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000208:ethnology / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human