title: Factors affecting the fate of faecal diversion in patients with perianal Crohn's disease.
abstract: OBJECTIVE
  A study was carried out with the aim of identifying potential factors which might influence the fate of patients undergoing faecal diversion by stoma in perianal Crohn's disease.
  
  
  METHODS
  Patients with severe perianal Crohn's disease undergoing faecal diversion between 1994 and 2012 were identified and the factors associated with stoma closure were assessed using univariate and multivariate analysis.
  
  
  RESULTS
  Of 138 diverted patients, 30 (22%) achieved stoma closure, 45 (33%) had a stoma with the rectum left in situ and 63 (45%) underwent proctectomy with permanent stoma formation after a mean follow-up of 5.7 years. Univariate analysis demonstrated that synchronous colonic (P = 0.004) or rectal (P = 0.021) disease involvement and an increased frequency of loose seton placement (P = 0.001) adversely affected successful stoma closure rates. Multivariate analysis indicated a significant association between the inability to achieve stoma closure and persisting rectal involvement (OR 7.5, 95% CI 2.4-33.4), one or two placements of a loose seton (OR 3.3, 95% CI 1.4-8.8) and more than two placements (OR 6.9, 95% CI 1.2-132.5). No specific medical management was associated with an improved stoma closure rate, including biological agents when these were available (P = 0.25).
  
  
  CONCLUSIONS
  The fate of temporary faecal diversion in patients with perianal Crohn's disease is adversely affected by aggressive disease characteristics. No particular treatment, including biological therapy, was associated with an improved outcome.
authors.affiliation: Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: J
authors.initials: J
authors.lastname: Gu
authors.forename: M A
authors.initials: MA
authors.lastname: Valente
authors.forename: F H
authors.initials: FH
authors.lastname: Remzi
authors.forename: L
authors.initials: L
authors.lastname: Stocchi
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001004:Anus Diseases / Q000150:complications / Q000601:surgery*; D003125:Colostomy; D003424:Crohn Disease / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D007081:Ileostomy; D008297:Male; D008875:Middle Aged; D011349:Proctitis / Q000150:complications / Q000601:surgery; D011446:Prospective Studies; D012008:Recurrence; D012720:Severity of Illness Index; D054047:Surgical Stomas / Q000473:pathology; D016896:Treatment Outcome
keywords: Crohn's proctitis; Perianal Crohn's disease; biological therapy; faecal diversion