title: Evaluation of pemphigus cases involving oral mucosa.
abstract: OBJECTIVE
  Pemphigus, defines a group of disorders in autoimmune etiology which could be life-threatening and clinical manifestations are mainly epithelial blistering affecting cutaneous and/or mucosal surfaces including oral mucosa. The aim of our study is to evaluate the clinical appearance of pemphigus with oral involvement by reported 15 pemphigus cases.
  
  
  METHODS
  This retrospective study of 15 cases of pemphigus obtained over a period of 7 years from 2006 to 2013 in Istanbul University, Dentistry Faculty, Oral Medicine and Surgery Department was designed.
  
  
  RESULTS
  Age distribution of pemphigus was from 15 to 59 years with an average age of 41.3 years. Of the 15 patients, the male:female ratio was 1:2.75 (4 male, 11 female). The most common clinical various of pemphigus was pemphigus vulgaris, diagnosed in all patients. The buccal mucosa (34.3%) was the most commonly affected site followed by tongue (20%), gingiva (17.1%), palate (11.4%), lips (11.4%) and floor of mouth (5.7%).
  
  
  CONCLUSIONS
  Our explanation of this conclusion, while speculative, is that socioeconomic situation related stress in males and hormonal changes like pregnancy and menostasis in females; systemic disease and using drugs; dental trauma and bruxism could be responsible for flare up in the disease.
authors.forename: Gizem
authors.initials: G
authors.lastname: Karagöz
authors.affiliation: Department of Oral Surgery and Medicine, Dental Faculty, Istanbul University, Millet cad. 34093 Çapa, Istanbul, Turkey, Tel: +90-212-4142020, Ext: 30353; Fax: +90-212-4142564; e-mail: bektaskk@istanbul.edu.tr.
authors.forename: Kivanç
authors.initials: K
authors.lastname: Bektaş-Kayhan
authors.forename: Meral
authors.initials: M
authors.lastname: Ünür