title: Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis.
abstract: BACKGROUND
  Interstitial lung disease (ILD) is a frequent complication in progressive systemic sclerosis (SSc), being present in 25% to 90% of cases.
  
  
  OBJECTIVE
  To evaluate whether serum levels of procollagen typei and iii aminoterminal propeptide (PINP and PIIINP) correlate with severity and patterns of ILD in Mexican women with SSc.
  
  
  METHODS
  Thirty three SSc patients were assessed for disease characteristics and anti-topoisomerase antibodies (topoi), and also underwent pulmonary function tests and high-resolution computed tomography (HRCT). Nineteen patients had ILD+SSc, and 14 had no lung involvement (no ILD-SSc); data were compared with those from 45 healthy controls. PINP and PIIINP were assessed in all 3 groups.
  
  
  RESULTS
  Patients with SSc had higher PINP and PIIINP vs controls (P=.001, P<.001, respectively). Compared to no ILD-SSc patients, those with ILD+SSc had longer disease duration in years (P=.005), higher modified Rodnan skin score (P<.001), higher Health Assessment Questionnaire-Disability-Index scores (P<.001), higher topoi U/mL (P<.001), PINP (49.28±28.63 vs. 32.12±18.58μg/L, P=.05), and PIIINP (4.33±1.03 vs. 2.67±1.26μg/L, P<.001) levels. ILD severity based on total HRCT correlated with PINP (r=.388, P=.03) and PIIINP (P=.594, P<.001). On adjusted analysis, ILD severity was associated with disease duration (P=.037), PIIINP (P=.038), and topoi (P=.045).
  
  
  CONCLUSIONS
  PINP and PIIINP are useful markers for severe ILD+SSc, suggesting they could play a role in the follow-up of this complication in SSc.
authors.affiliation: Departamento de Medicina Interna-Reumatología y Neumología, Hospital General Regional 110, IMSS, Guadalajara, México; Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México.
authors.forename: Laura
authors.initials: L
authors.lastname: Gonzalez-Lopez
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México; Programa Postdoctoral, Consejo Nacional de Ciencia y Tecnología (CONACYT), México D. F., México.
authors.forename: Alberto D
authors.initials: AD
authors.lastname: Rocha-Muñoz
authors.affiliation: Hospital General Regional 180 IMSS, Tlajomulco, México.
authors.forename: Eva M
authors.initials: EM
authors.lastname: Olivas-Flores
authors.affiliation: Department of Symptoms Research, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
authors.forename: Araceli
authors.initials: A
authors.lastname: Garcia-Gonzalez
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, México.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Peguero-Gómez
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, México.
authors.forename: Juan
authors.initials: J
authors.lastname: Flores-Navarro
authors.affiliation: Unidad de Medicina Familiar y Cirugía Ambulatoria no. 52 IMSS, Guadalajara, México.
authors.forename: Alberto I
authors.initials: AI
authors.lastname: Villa-Manzano
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México.
authors.forename: Soraya A
authors.initials: SA
authors.lastname: Zavaleta-Muñiz
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México; Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, México.
authors.forename: Mario
authors.initials: M
authors.lastname: Salazar-Paramo
authors.affiliation: Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas, México D.F., México.
authors.forename: Mayra
authors.initials: M
authors.lastname: Mejía
authors.affiliation: Departamento de Medicina Interna-Reumatología y Neumología, Hospital General Regional 110, IMSS, Guadalajara, México.
authors.forename: Pablo
authors.initials: P
authors.lastname: Juárez-Contreras
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México.
authors.forename: Monica
authors.initials: M
authors.lastname: Vazquez-Del Mercado
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México.
authors.forename: Ernesto G
authors.initials: EG
authors.lastname: Cardona-Muñoz
authors.affiliation: Unidad de Investigación y Epidemiología Clínica, Hospital General de Zona y Medicina Familiar No. 1, Instituto Mexicano del Seguro Social (IMSS), Colima, México.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Trujillo-Hernández
authors.affiliation: Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, México; Programa Internacional, Facultad de Medicina, Universidad Autonoma de Guadalajara. Guadalajara, México.
authors.forename: Arnulfo H
authors.initials: AH
authors.lastname: Nava-Zavala
authors.affiliation: Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, México; Unidad de Investigación en Epidemiología Clínica, Departamento de Radiodiagnóstico y División de Investigación, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, México. Electronic address: drivangamez@prodigy.net.mx.
authors.forename: Jorge I
authors.initials: JI
authors.lastname: Gamez-Nava
mesh_terms: D024042:Collagen Type I / Q000097:blood*; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood* / Q000209:etiology*; D008800:Mexico; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012595:Scleroderma, Systemic / Q000097:blood* / Q000150:complications*; D012720:Severity of Illness Index
chemical_list: D024042:Collagen Type I; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide
keywords: Enfermedad pulmonar intersticial; Esclerosis sistémica progresiva; High-resolution computed tomography; Interstitial lung disease; Procollagen type i aminoterminal propeptide; Procollagen type iii aminoterminal propeptide; Progressive systemic sclerosis; Propéptido aminoterminal de procolágeno tipo i; Propéptido aminoterminal de procolágeno tipo iii; Tomografía computarizada de alta resolución