title: No relationship between osteoprotegerin concentrations and endothelial dysfunction in non-obese women with and without polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the relationships of osteoprotegerin (OPG) concentrations to brachial artery flow-mediated vasodilation (FMD) and the carotid artery intima media thickness (CIMT) in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Thirty-seven women with PCOS and 41 controls matched for body mass index (BMI) and age were included in study. The serum OPG concentrations, hormonal and metabolic profiles were measured in women with PCOS and in control group. The CIMT and brachial artery FMD were evaluated in both groups.
  
  
  RESULTS
  The mean serum concentrations of all hormones were comparable, except LH, which was higher in women with PCOS. Lipid parameters were similar between groups. There were no differences between groups with respect to fasting glucose, 2-h glucose, fasting insulin, HbA1c and HOMA-IR. The mean osteoprotogerin concentrations were higher in PCOS group (11.39 ± 2.29 vs. 10.22 ± 2.25 pmol/L, P = 0.026). The mean CIMT was higher in PCOS group than control group (0.52 ± 0.058 vs. 0.45 ± 0.059 mm, P < 0.01). The mean brachial artery FMD was lower in PCOS group (0.068 ± 0.022 vs. 0.055 ± 0.029, P = 0.017).
  
  
  CONCLUSIONS
  We found high osteoprotogerin concentrations, increased CIMT and decreased FMD, in women with PCOS. However, there was no correlation between osteoprotegerin and cardiovascular risk markers.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Namik Kemal University, 100. YilMah. Barbaros Cad, No: 132, Tekirdag, Turkey, remziabali@yahoo.com.
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.forename: Nicel
authors.initials: N
authors.lastname: Tasdemir
authors.forename: Seref
authors.initials: S
authors.lastname: Alpsoy
authors.forename: Ufuk Göker
authors.initials: UG
authors.lastname: Tasdemir
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.forename: Mehmet Aytac
authors.initials: MA
authors.lastname: Yuksel
authors.forename: Ilkbal
authors.initials: I
authors.lastname: Temel Yuksel
authors.forename: Murat
authors.initials: M
authors.lastname: Yilmaz
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000503:physiopathology; D053244:Osteoprotegerin / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012307:Risk Factors; D014664:Vasodilation / Q000502:physiology
chemical_list: D008055:Lipids; D053244:Osteoprotegerin