title: Facing the challenges of ventricular hypertrophy: the eyes don't lie.
abstract: We describe the case of a 47-year-old man with new-onset heart failure who was found to have severe biventricular wall thickening. We present comprehensive data from invasive and non-invasive multimodality imaging, genetic and histologic tests, and briefly describe their importance in the final diagnosis. To our knowledge, this is the first case of the Portuguese variant of familial amyloid polyneuropathy presenting with heart failure in the fifth decade of life. This is an unusual case report, but also an illustration of how to approach any patient with suspected infiltrative cardiomyopathy.
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal. Electronic address: pfdrodrigues@gmail.com.
authors.forename: Patrícia
authors.initials: P
authors.lastname: Rodrigues
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Mário
authors.initials: M
authors.lastname: Santos
authors.affiliation: Internal Medicine Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: António
authors.initials: A
authors.lastname: Marinho
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Sofia
authors.initials: S
authors.lastname: Cabral
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Miguel
authors.initials: M
authors.lastname: Vieira
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Hipólito
authors.initials: H
authors.lastname: Reis
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Palma
authors.affiliation: Cardiology Department, Centro Hospitalar do Porto, Porto, Portugal.
authors.forename: Severo
authors.initials: S
authors.lastname: Torres
mesh_terms: D006332:Cardiomegaly / Q000150:complications / Q000000981:diagnostic imaging*; D006333:Heart Failure / Q000209:etiology; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
keywords: Cardiomiopatia infiltrativa; Echocardiography; Ecocardiografia; Familial amyloid polyneuropathy; Heart failure; Hipertrofia ventricular; Infiltrative cardiomyopathy; Insuficiência cardíaca; Polineuropatia amiloidótica familiar; Ventricular wall thickening