title: Decreased serum platelet derived growth factor BB levels in acute and increased in chronic pancreatitis.
abstract: OBJECTIVE
  To examine circulating growth factor concentrations in patients with acute pancreatitis (AP) and chronic pancreatitis (CP), and walled-off pancreatic necrosis (WOPN).
  
  
  METHODS
  Forty patients with mild AP, 40 patients with alcoholic CP, 33 patients with WOPN and 40 healthy subjects were examined. Serum concentrations of platelet derived growth factor BB (PDGF-BB), transforming growth factor β-1 (TGFβ-1), chemerin and high-mobility group box chromosomal protein 1 (HMBG1) were assayed by enzyme linked immunosorbent assay.
  
  
  RESULTS
  Patients with mild AP and those with WOPN had significantly lower serum levels of PDGF-BB compared to healthy subjects (4.0 ± 0.61 ng/mL vs 6.2 ± 0.76 ng/mL, P = 0.027, and 1.60 ± 0.31 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001, respectively), while CP was associated with higher serum levels of PDGF-BB (12 ± 1.3 ng/mL vs 6.2 ± 0.76 ng/mL, P < 0.001). Circulating TGFβ-1 and chemerin levels were elevated in CP patients (57 ± 3.6 ng/mL vs 39 ± 3.6 ng/mL, P < 0.001 and 73 ± 7.2 ng/mL vs 48 ± 2.3 ng/mL, P < 0.001, respectively), but not in patients with AP and WOPN. No significant changes in serum HMBG1 levels were found either in patients with AP, WOPN or CP.
  
  
  CONCLUSIONS
  The serum levels of some growth factors and cytokines differ significantly in AP, WOPN and CP. These data suggest that selected growth factors and cytokines may be considered as potential diagnostic biomarkers in patients with pancreatic diseases.
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Stojek
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Krystian
authors.initials: K
authors.lastname: Adrych
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Rojek
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Smoczynski
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Sledzinski
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Sylwia
authors.initials: S
authors.lastname: Szrok
authors.affiliation: Magdalena Stojek, Krystian Adrych, Lukasz Rojek, Marian Smoczynski, Department of Gastroenterology and Hepatology, Medical University of Gdansk, 80-952 Gdansk, Poland.
authors.forename: Julian
authors.initials: J
authors.lastname: Swierczynski
mesh_terms: D000328:Adult; D000077214:Becaplermin; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015536:Down-Regulation; D004797:Enzyme-Linked Immunosorbent Assay; D024243:HMGB1 Protein / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D019283:Pancreatitis, Acute Necrotizing / Q000097:blood* / Q000175:diagnosis; D019512:Pancreatitis, Alcoholic / Q000097:blood* / Q000175:diagnosis; D050500:Pancreatitis, Chronic / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D020574:Proto-Oncogene Proteins c-sis / Q000097:blood*; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000097:blood; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; C585491:HMGB1 protein, human; D020574:Proto-Oncogene Proteins c-sis; C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1; D000077214:Becaplermin
keywords: Acute pancreatitis; Chemerin; Chronic pancreatitis; Growth factors; High-mobility group box chromosomal protein 1; Platelet derived growth factor BB; Transforming growth factor β-1; Walled-off pancreatic necrosis