title: Enantioselective discrimination of alcohols by hydrogen bonding: a SERS study.
abstract: Efficient and generic enantioselective discrimination of various chiral alcohols is achieved by using surface-enhanced Raman scattering (SERS) spectroscopy through charge-transfer (CT) contributions. The relative intensities of the peaks in the SERS spectra of a chiral selector are strongly dependent on the chirality of its surroundings. This highly distinct spectral discrepancy may be due to the tendency of chiral isomers to form intermolecular hydrogen-bonding complexes with the chiral selector in different molecular orientations, resulting in different CT states and SERS intensities of the adsorbates in the system. This study opens a new avenue leading to the development of novel enantiosensing strategies. A particular advantage of this approach is that it is label-free and does not employ any chiral reagents, including chiral light.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China).
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Huimin
authors.initials: H
authors.lastname: Sui
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ozaki
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D006860:Hydrogen Bonding; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D000438:Alcohols
keywords: charge transfer; chiral recognition; hydrogen bonding; surface-enhanced Raman scattering