title: Effect of catecholamines, glucose, insulin, and changes of flow on the metabolism of free fatty acids by the myocardium.
abstract: Isolated rabbit hearts were perfused with a suspension of red blood cells in a buffer solution containing palmitate-1-C14 complexed to albumin. Arteriovenous differences of radioactivity in free fatty acids (FFA) and CO2 were measured after addition of epinephrine, norepinephrine, glucose and insulin under conditions of constant arterial concentration of FFA and rate of perfusion. Both norepinephrine and epinephrine increased the oxidation of free fatty acids to CO2 (48 and 53 per cent, respectively) but neither altered their extraction by the myocardium. Addition of glucose alone or glucose with insulin influenced neither the extraction nor the oxidation of FFA. Under the conditions of study, uptake of FFA by the heart was strictly proportional to the rate of perfusion.
authors.forename: Aristides
authors.initials: A
authors.lastname: Gousios
authors.forename: James M
authors.initials: JM
authors.lastname: Felts
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Havel
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000494:pharmacology*; D004837:Epinephrine; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine; D010084:Oxidation-Reduction; D010477:Perfusion; D011817:Rabbits
chemical_list: D002395:Catecholamines; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D007328:Insulin; D005947:Glucose; D009638:Norepinephrine; D004837:Epinephrine