title: Transmembrane signalling by the T3-antigen receptor complex.
abstract: Monoclonal antibodies to the T-cell antigen receptor can mimic the effects of antigen and induce cellular activation. In this article john Imboden and his colleagues report on the use of these antibodies as probes to study the mechanism by which the antigen receptor initiates activation. They also describe the critical role of cytoplasmic free calcium in transmembrane signal transduction by the T-cell antigen receptor.
authors.affiliation: The Howard Hughes Medical Institute and the Department of Medicine, University of California, San Francisco, CA 94143, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Imboden
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: J D
authors.initials: JD
authors.lastname: Stobo