title: Idiopathic inflammatory myopathies evaluated by near-infrared spectroscopy.
abstract: BACKGROUND
  In this study we evaluated whether near-infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion-body myositis (IBM).
  
  
  METHODS
  We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post-occlusion hyperemia.
  
  
  RESULTS
  DM showed lower oxygen consumption (P=0.04) during VOT and reduced oxygen supply after VOT (P=0.04) compared with controls. IBM patients showed higher oxygen consumption (P=0.04) during VOT and higher oxygen supply after VOT (P=0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM (P=0.001), and an impaired ability to supply oxygen compared with PM (P=0.03) and IBM (P=0.001) patients.
  
  
  CONCLUSIONS
  NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects.
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Caliandro
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mirabella
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.|Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Padua
authors.affiliation: Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Simbolotti
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Chiara De
authors.initials: CD
authors.lastname: Fino
authors.affiliation: Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Iacovelli
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Sancricca
authors.affiliation: Department of Geriatrics, Neuroscience, Orthopedics, and Physiatrics, Institute of Neurology, Catholic University, Rome, Italy.|IRCSS S. Raffaele Pisana, Rome, Italy.
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D009220:Myositis / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology; D010108:Oxyhemoglobins / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared; D013997:Time Factors; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D016756:Immunoglobulins, Intravenous; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin
keywords: NIRS; dermatomyositis; inclusion-body myositis; inflammatory myopathy; polymyositis