title: Development of new P-chiral P,π-dihydrobenzooxaphosphole hybrid ligands for asymmetric catalysis.
abstract: A new family of P-chiral P,π-hybrid ligands was prepared from the dihydrobenzooxaphosphole core. These new ligands were demonstrated to be both sterically and electronically tunable at the substituents on the phosphorus atom and the π-system of the ligand. Application of these new ligands to the catalytic asymmetric addition of boronic acids to imine electrophiles was shown to proceed with high levels of enantioinduction.
authors.affiliation: Department of Chemical Development, Boehringer Ingelheim Phamaceuticals, Inc. , 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States.
authors.forename: Joshua D
authors.initials: JD
authors.lastname: Sieber
authors.forename: Divya
authors.initials: D
authors.lastname: Chennamadhavuni
authors.forename: Keith R
authors.initials: KR
authors.lastname: Fandrick
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.forename: Zhengxu S
authors.initials: ZS
authors.lastname: Han
authors.forename: Jolaine
authors.initials: J
authors.lastname: Savoie
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Lalith P
authors.initials: LP
authors.lastname: Samankumara
authors.forename: Nelu
authors.initials: N
authors.lastname: Grinberg
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake