title: Peripapillary and macular choroidal thickness in glaucoma.
abstract: OBJECTIVE
  To compare choroidal thickness (CT) between individuals with and without glaucomatous damage and to explore the association of peripapillary and submacular CT with glaucoma severity using spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Ninety-one eyes of 20 normal subjects and 43 glaucoma patients from the UCLA SD-OCT Imaging Study were enrolled. Imaging was performed using Cirrus HD-OCT. Choroidal thickness was measured at four predetermined points in the macular and peripapillary regions, and compared between glaucoma and control groups before and after adjusting for potential confounding variables.
  
  
  RESULTS
  The average (± standard deviation) mean deviation (MD) on visual fields was -0.3 (±2.0) dB in controls and -3.5 (±3.5) dB in glaucoma patients. Age, axial length and their interaction were the most significant factors affecting CT on multivariate analysis. Adjusted average CT (corrected for age, axial length, their interaction, gender and lens status) however, was not different between glaucoma patients and the control group (P=0.083) except in the temporal parafoveal region (P=0.037); nor was choroidal thickness related to glaucoma severity (r=-0.187, P=0.176 for correlation with MD, r=-0.151, P=0.275 for correlation with average nerve fiber layer thickness).
  
  
  CONCLUSIONS
  Choroidal thickness of the macular and peripapillary regions is not decreased in glaucoma. Anatomical measurements with SD-OCT do not support the possible influence of the choroid on the pathophysiology of glaucoma.
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hosseini
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA ; Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Naveed
authors.initials: N
authors.lastname: Nilforushan
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA ; Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Elena
authors.initials: E
authors.lastname: Bitrian
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Jay
authors.initials: J
authors.lastname: Riddle
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Gina Yoo
authors.initials: GY
authors.lastname: Lee
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Caprioli
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, CA, USA.
authors.forename: Kouros
authors.initials: K
authors.lastname: Nouri-Mahdavi
keywords: Choroidal Thickness; Glaucoma; Macula; Peripapillary; Spectral-Domain Optical Coherence Tomography