title: Ten-year follow-up of two unrelated patients with Müller cell sheen dystrophy and first report of successful vitrectomy.
abstract: OBJECTIVE
  To describe clinical characteristics of Müller cell sheen dystrophy (MCSD) in two unrelated patients followed for 10 years.
  
  
  METHODS
  Best-corrected visual acuity (BCVA), kinetic perimetry, biomicroscopy, ophthalmoscopy, fundus photography, fluorescein angiography, fundus autofluorescence, near-infrared reflectance, optical coherence tomography (OCT), and electroretinography (ERG).
  
  
  RESULTS
  Case 1: A 61-year-old woman showed internal limiting membrane (ILM) folds at the posterior pole (OU), and cystoid macular edema (CME) in OD. During follow-up, BCVA decreased from 0.2 to 0.06 (OD) and from 0.7 to hand movements (OS). Fundus presented fluctuant CME and subretinal fluid, and an increase in ILM folds and intraretinal schisis cavities. ERG was negative in OD and initially normal in OS. Case 2: A 60-year-old man was first diagnosed with epiretinal membrane before MCSD with ILM folds was detected. OCT showed schisis cavities in all retinal layers. After vitrectomy with ILM peeling in OD because of visual loss and massive CME, BCVA recovered from 0.05 to 0.4. BCVA in OS remained at 0.6. OD developed negative ERG.
  
  
  CONCLUSIONS
  MCSD presents with late onset, ILM folds, intraretinal schisis cavities, and negative ERG. Visual loss is accompanied by CME and subretinal fluid. Vitrectomy with ILM peeling led to BCVA increase and anatomic improvement.
authors.affiliation: Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany, a.renner@berlin.de.
authors.forename: Agnes B
authors.initials: AB
authors.lastname: Renner
authors.forename: Viola
authors.initials: V
authors.lastname: Radeck
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kellner
authors.forename: Herbert
authors.initials: H
authors.lastname: Jägle
authors.forename: Horst
authors.initials: H
authors.lastname: Helbig
mesh_terms: D000368:Aged; D004596:Electroretinography; D063928:Ependymoglial Cells / Q000473:pathology*; D019773:Epiretinal Membrane / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D013508:Ophthalmologic Surgical Procedures; D009887:Ophthalmoscopy; D012160:Retina / Q000503:physiopathology; D058499:Retinal Dystrophies / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014821:Vitrectomy