title: Complementary treatment of contact lens-induced corneal ulcer using honey: a case report.
abstract: The aim of this study was to report the complementary use of honey for treatment of a contact lens-induced corneal ulcer. A 23-year-old contact lens user presented with a corneal ulcer in her left eye. She had visual acuity reduced to hand movement. There was a history of wearing contact lenses while swimming in a lake seven days before presentation. The cultures from corneal scrapings and contact lenses were positive for Klebsiella oxytoca, Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Pseudomonas spp. The treatment with topical levofloxacin and 25% (w/v) γ-irradiated honeydew honey solution was effective and the patient achieved final best corrected visual acuity of affected eye. In addition to positive clinical outcome, honeydew honey was shown to be highly effective in vitro against ocular isolates, in particular S. maltophilia. The minimal inhibitory concentrations for honeydew honey ranged from 5% to 10%. These results demonstrate that honey is a promising antibacterial agent in management of corneal ulcers. Moreover, honey exhibits anti-biofilm and anti-inflammatory properties, and thus becomes an interesting ophthalmologic agent.
authors.affiliation: Department of Ophthalmology, University Hospital and Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Nora
authors.initials: N
authors.lastname: Majtanova
authors.affiliation: Department of Ophthalmology, University Hospital and Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Erika
authors.initials: E
authors.lastname: Vodrazkova
authors.affiliation: Department of Ophthalmology, University Hospital and Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Veronika
authors.initials: V
authors.lastname: Kurilova
authors.affiliation: Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Horniackova
authors.affiliation: Department of Ophthalmology, University Hospital and Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Martin
authors.initials: M
authors.lastname: Cernak
authors.affiliation: Department of Ophthalmology, University Hospital and Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia.
authors.forename: Andrej
authors.initials: A
authors.lastname: Cernak
authors.affiliation: Department of Microbiology, Faculty of Medicine, Slovak Medical University, Bratislava, Slovakia; Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address: Juraj.Majtan@savba.sk.
authors.forename: Juraj
authors.initials: J
authors.lastname: Majtan
mesh_terms: D000529:Complementary Therapies / Q000379:methods*; D003261:Contact Lenses / Q000009:adverse effects* / Q000382:microbiology; D003320:Corneal Ulcer / Q000209:etiology / Q000382:microbiology / Q000628:therapy*; D015818:Eye Infections, Bacterial / Q000209:etiology / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006722:Honey; D006801:Humans; D014792:Visual Acuity; D055815:Young Adult
keywords: Corneal ulcer; Honey; Stenotrophomonas maltophilia