title: Fatty acids rehabilitated long-term neurodegenerative: like symptoms in olfactory bulbectomized rats.
abstract: Our previous study demonstrated that an olfactory bulbectomy in rats induced short-term, multifaceted, devastating Alzheimer's-like effects, which included cognitive impairment, hyperactivity, hyperthermia, and increased levels of homocysteine and pro-inflammatory cytokines, including IL-17A. In addition, the rats exhibited an increase in the hyperphosphorylation of brain Tau proteins and in the number of neurofibrillary tangles. Here, we examined the long-term effects of the surgery and found that olfactory bulbectomy also rendered the rats to become anemic with brain iron overload. Additionally, a significant reduction in the membrane fluidity index in frontal cortex synaptosomes was found. Treatment with a mixture of n - 3/n - 6 of fatty acids restored the unwanted effect. The beneficial effects of fatty acids are mediated via the effects of fatty acids on the neuronal membrane structure and fluidity. These findings are similar to Alzheimer's symptoms, which suggest this model can be used as an animal model for Alzheimer's disease. We recommend using this model to scan potential new anti-Alzheimer's drugs.
authors.affiliation: Psychopharmacology Lab, Department of Psychology, Bar Ilan University, 52900, Ramat Gan, Israel, Yehudas@mail.biu.ac.il.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Yehuda
authors.forename: Sharon
authors.initials: S
authors.lastname: Rabinovitz
mesh_terms: D000544:Alzheimer Disease; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D004435:Eating / Q000187:drug effects / Q000502:physiology; D005227:Fatty Acids / Q000008:administration & dosage*; D006710:Homocysteine / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D009830:Olfactory Bulb / Q000503:physiopathology*; D020318:Rats, Long-Evans; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
chemical_list: D016207:Cytokines; D005227:Fatty Acids; D018696:Neuroprotective Agents; D006710:Homocysteine; D002784:Cholesterol; D007501:Iron