title: Chromatin yo-yo: expansion and condensation during DNA repair.
abstract: DNA double-strand breaks are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). Disrupting the balance between these pathways results in toxic chromosomal rearrangements. Several recent studies are revealing that dynamic changes in chromatin conformation can regulate DNA repair pathway choice both spatially and temporally.
authors.affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160.
authors.forename: Mischa L
authors.initials: ML
authors.lastname: Li
authors.affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160.
authors.forename: Gang
authors.initials: G
authors.lastname: Yuan
authors.affiliation: Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160.|Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104-6160.
authors.forename: Roger A
authors.initials: RA
authors.lastname: Greenberg
mesh_terms: D019313:BRCA1 Protein / Q000502:physiology*; D006657:Histones / Q000502:physiology*; D006801:Humans
chemical_list: D019313:BRCA1 Protein; D006657:Histones
keywords: DNA repair; chromatin; homologous recombination