title: [First Russian nationwide molecular epidemiological study for melanoma: results of BRAF mutation analysis].
abstract: This report presents the initial results of the first Russian molecular epidemiological study of melanoma. The investigation included 1035 patients with stage IIIB-IV melanoma residing in various regions of Russia. Sequencing of BRAF gene revealed mutation in 627 (60.6%) tumors; c.1799T > A (p.V600E) substitution was detected in 563 cases, and other mutations in 64 melanomas. Frequency of BRAF alterations was significantly higher in patients of younger age (< 50 years: 72.9%; > or = 50 years: 57.1%; p = 0.00003). 710 melanomas included in the study were located in sun non-exposed regions of the skin; this category of tumors was characterized by the highest occurrence of BRAF mutations (63.9%). In conclusion, more than a half of Russian patients with advanced melanoma are potential candidates for the treatment of kinase inhibitors of mutated BRAF.
authors.forename: G A
authors.initials: GA
authors.lastname: Frank
authors.forename: L E
authors.initials: LE
authors.lastname: Zavalishina
authors.forename: T V
authors.initials: TV
authors.lastname: Kekeeva
authors.forename: S N
authors.initials: SN
authors.lastname: Aleksakhina
authors.forename: T R
authors.initials: TR
authors.lastname: Garifullina
authors.forename: O A
authors.initials: OA
authors.lastname: Ivantsov
authors.forename: N V
authors.initials: NV
authors.lastname: Mitiushkina
authors.forename: V
authors.initials: V
authors.lastname: Pfaifer
authors.forename: T N
authors.initials: TN
authors.lastname: Strelkova
authors.forename: E N
authors.initials: EN
authors.lastname: Imianitova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D017720:Molecular Epidemiology; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000235:genetics*; D012426:Russia; D012878:Skin Neoplasms; D044465:White People; D000096142:Cutaneous Malignant Melanoma
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf