title: Protocol for economic evaluation alongside a cluster-randomised controlled trial of a psychoeducational intervention for the primary prevention of postnatal mental health problems in first-time mothers.
abstract: BACKGROUND
  Postnatal mental health problems, which are an international public health priority, are a suitable target for preventive approaches. The financial burden of these disorders is borne across sectors in society, including health, early childhood, education, justice and the workforce. This paper describes the planned economic evaluation of What Were We Thinking, a psychoeducational intervention for the prevention of postnatal mental health problems in first-time mothers.
  
  
  METHODS
  The evaluation will be conducted alongside a cluster-randomised controlled trial of its clinical effectiveness. Cost-effectiveness and costs-utility analyses will be conducted, resulting in estimates of cost per percentage point reduction in combined 30-day prevalence of depression, anxiety and adjustment disorders and cost per quality-adjusted life year gained. Uncertainty surrounding these estimates will be addressed using non-parametric bootstrapping and represented using cost-effectiveness acceptability curves. Additional cost analyses relevant for implementation will also be conducted. Modelling will be employed to estimate longer term cost-effectiveness if the intervention is found to be clinically effective during the period of the trial.
  
  
  BACKGROUND
  Approval to conduct the study was granted by the Southern Health (now Monash Health) Human Research Ethics Committee (24 April 2013; 11388B). The study was registered with the Monash University Human Research Ethics Committee (30 April 2013; CF12/1022-2012000474). The Education and Policy Research Committee, Victorian Government Department of Education and Early Childhood Development approved the study (22 March 2012; 2012_001472). Use of the EuroQol was registered with the EuroQol Group; 16 August 2012.
  
  
  BACKGROUND
  The trial was registered with the Australian New Zealand Clinical Trials Registry on 7 May 2012 (registration number ACTRN12613000506796).
authors.affiliation: Centre for Health Economics, Monash University, Clayton, Victoria, Australia.
authors.forename: Jemimah
authors.initials: J
authors.lastname: Ride
authors.affiliation: Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: Heather
authors.initials: H
authors.lastname: Rowe
authors.affiliation: Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: Karen
authors.initials: K
authors.lastname: Wynter
authors.affiliation: Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
authors.forename: Jane
authors.initials: J
authors.lastname: Fisher
authors.affiliation: Centre for Health Economics, Monash University, Clayton, Victoria, Australia.
authors.forename: Paula
authors.initials: P
authors.lastname: Lorgelly
mesh_terms: D000275:Adjustment Disorders / Q000191:economics* / Q000517:prevention & control; D001008:Anxiety Disorders / Q000191:economics* / Q000517:prevention & control; D001315:Australia; D003362:Cost-Benefit Analysis; D019052:Depression, Postpartum / Q000191:economics* / Q000517:prevention & control; D005260:Female; D006801:Humans; D001523:Mental Disorders / Q000191:economics / Q000517:prevention & control; D009035:Mothers / Q000193:education* / Q000523:psychology; D010353:Patient Education as Topic / Q000191:economics* / Q000379:methods; D011322:Primary Prevention / Q000191:economics* / Q000379:methods; D011644:Puerperal Disorders / Q000191:economics / Q000517:prevention & control
keywords: HEALTH ECONOMICS; MENTAL HEALTH; PUBLIC HEALTH