title: Western dietary pattern interaction with APOC3 polymorphism in the risk of metabolic syndrome: Tehran Lipid and Glucose Study.
abstract: OBJECTIVE
  Gene-dietary pattern interactions may contribute to the determination of a susceptibility to metabolic syndrome (MetS). The aim of this study was to evaluate the potential interactions of dietary patterns with the common genetic variant of APOC3 in relation to MetS in adults.
  
  
  METHODS
  In this individual matched nested case-control study, 755 MetS subjects and 755 controls were selected from among participants in the Tehran Lipid and Glucose Study. Dietary patterns were determined by factor analysis. APOC3 3238C>G rs5128 was genotyped by polymerase chain reaction and restriction fragment length polymorphism.
  
  
  RESULTS
  Fat-sweet, healthy and Western dietary patterns (WDP) were extracted from the data. In the joint analysis, the associations of the WDP and APOC3 rs5128 with MetS risk tended to be dependent on APOC3 3238C>G gene variants (p for interaction = 0.009) in women. The MetS risk was increased in women with the CC genotype with increasing tertiles of WDP scores compared with women with the CG + GG genotype, whose MetS risk was decreased with increasing tertiles of WDP scores. In addition, we found that intakes of fast food, salty snacks and soft drinks showed significant interactions with the rs5128 genotypes in relation to MetS risk (p for interactions <0.05).
  
  
  CONCLUSIONS
  The results obtained demonstrate a diet-gene interaction between APOC3 rs5128 polymorphism and the WDP in relation to MetS risk.
authors.affiliation: Nutrition and Endocrine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Hosseini-Esfahani
authors.forename: Parvin
authors.initials: P
authors.lastname: Mirmiran
authors.forename: Maryam S
authors.initials: MS
authors.lastname: Daneshpour
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Mehrabi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Hedayati
authors.forename: Maryam
authors.initials: M
authors.lastname: Zarkesh
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
mesh_terms: D000328:Adult; D053305:Apolipoprotein C-III / Q000235:genetics*; D001786:Blood Glucose / Q000737:chemistry; D015992:Body Mass Index; D016022:Case-Control Studies; D004032:Diet; D066273:Diet, Western; D005260:Female; D005838:Genotype; D006801:Humans; D007492:Iran; D016018:Least-Squares Analysis; D008055:Lipids / Q000737:chemistry; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D053305:Apolipoprotein C-III; D001786:Blood Glucose; D008055:Lipids