title: Short-term outcome of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: preliminary analysis of a multicentre study.
abstract: OBJECTIVE
  To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy.
  
  
  METHODS
  A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis.
  
  
  RESULTS
  In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity.
  
  
  CONCLUSIONS
  Careful patient selection has to be performed to improve clinical outcomes.
authors.affiliation: Department of Human Pathology, University of Messina, Messina, Italy amacri@unime.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Macrì
authors.affiliation: Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Arcoraci
authors.affiliation: Department of Surgery, University of Genoa, Genoa, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Belgrano
authors.affiliation: 1st Department of General Surgery, University of Verona, Verona, Italy.
authors.forename: Marina
authors.initials: M
authors.lastname: Caldana
authors.affiliation: Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Cioppa
authors.affiliation: Department of Obstetrics & Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Costantini
authors.affiliation: Department of Human Pathology, University of Messina, Messina, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Cucinotta
authors.affiliation: Department of Surgery, University of Genoa, Genoa, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: De Cian
authors.affiliation: Gynecologic Oncology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Pierandrea
authors.initials: P
authors.lastname: De Iaco
authors.affiliation: 1st Department of General Surgery, University of Verona, Verona, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Manzoni
authors.affiliation: Department of Surgery "Pietro Valdoni", University "Sapienza" of Rome, Rome, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Di Giorgio
authors.affiliation: Department of Human Pathology, University of Messina, Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Fleres
authors.affiliation: Department of Surgery, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Muffatti
authors.affiliation: Department of Surgery, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Orsenigo
authors.affiliation: Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital, Bologna, Italy.
authors.forename: Antonio Daniele
authors.initials: AD
authors.lastname: Pinna
authors.affiliation: Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
authors.forename: Franco
authors.initials: F
authors.lastname: Roviello
authors.affiliation: Department of Surgery "Pietro Valdoni", University "Sapienza" of Rome, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sammartino
authors.affiliation: Department of Obstetrics & Gynaecology, Catholic University of Sacred Heart, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Scambia
authors.affiliation: Department of Human Pathology, University of Messina, Messina, Italy.
authors.forename: Edoardo
authors.initials: E
authors.lastname: Saladino
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002423:Cause of Death; D010478:Chemotherapy, Cancer, Regional Perfusion; D003131:Combined Modality Therapy; D015897:Comorbidity; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome
keywords: Cytoreductive surgery; HIPEC; hyperthermia; morbidity; mortality