title: Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines.
abstract: Arthritis is an inflammatory disease of joints. Exact etiology of the disease is not understood yet; but histopathological examination of vital organs like liver, kidney, ovary and knee joint can anticipate immune mediated damage. In this study, Lactobacillus acidophilus was administered orally by both prophylactic and curative protocol in freund's complete adjuvant induced arthritic rats. Indomethacin was used as standard anti-arthritic drug. Histopathology of liver, kidney, ovary and right hind knee joint were done. Cytokine concentrations were determined by using ELISA. Effects shown by L. acidophilus were comparable with indomethacin. Histopathological analysis of liver, kidney, ovaries and knee joints of L. acidophilus fed groups revealed significantly less damage as compared with other counterparts. Lactobacillus treatment has down-regulated pro-inflammatory level and up-regulated anti-inflammatory cytokines level in serum samples. L. acidophilus managed organs damage associated with arthritis. It has significantly down regulated the pro-inflammatory cytokines.
authors.affiliation: Department of Microbiology, Barkatullah University, Hoshangabad Road Habibganj, Bhopal, 462026 Madhya Pradesh India.
authors.forename: Sarika
authors.initials: S
authors.lastname: Amdekar
authors.affiliation: Department of Microbiology, Barkatullah University, Hoshangabad Road Habibganj, Bhopal, 462026 Madhya Pradesh India.
authors.forename: Vinod
authors.initials: V
authors.lastname: Singh
authors.affiliation: Department of Biotechnology, Dr. B. R. Ambedkar University, Agra, 282004 India.
authors.forename: Avnish
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Zoology, Bundelkhand University, Kanpur Road, Jhansi, 28400 Uttar Pradesh India.
authors.forename: Poonam
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Department of Biomedical Sciences, Bundelkhand University, Kanpur Road, Jhansi, 284001 Uttar Pradesh India.
authors.forename: Rambir
authors.initials: R
authors.lastname: Singh
keywords: Bone damage; Freund’s complete adjuvant; Neutrophil infiltrations; Probiotics