title: Polymorphisms in lipogenic genes and milk fatty acid composition in Holstein dairy cattle.
abstract: Changing bovine milk fatty acid (FA) composition through selection can decrease saturated FA (SFA) consumption, improve human health and provide a means for manipulating processing properties of milk. Our study determined associations between milk FA composition and genes from triacylglycerol (TAG) biosynthesis pathway. The GC dinucleotide allele of diacylglycerol O-acyltransferase 1:g.10433-10434AA >GC was associated with lower palmitic acid (16:0) concentration but higher oleic (18:1 cis-9), linoleic (18:2 cis-9, cis-12) acid concentrations, and elongation index. Accordingly, the GC dinucleotide allele was associated with lower milk fat percentage and SFA concentrations but higher monounsaturated FA and polyunsaturated FA (PUFA) concentrations. The glycerol-3-phosphate acyltransferase, mitochondrial haplotypes were associated with higher myristoleic acid (14:1 cis-9) concentration and C14 desaturation index. The 1-acylglycerol-3-phosphate acyltransferase 1 haplotypes were associated with higher PUFA and linoleic acid concentrations. The results of this study provide information for developing genetic tools to modify milk FA composition in dairy cattle.
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: Rafael A
authors.initials: RA
authors.lastname: Nafikov
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA. Electronic address: jschoonm@purdue.edu.
authors.forename: Jon P
authors.initials: JP
authors.lastname: Schoonmaker
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: Kathleen T
authors.initials: KT
authors.lastname: Korn
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Noack
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: Dorian J
authors.initials: DJ
authors.lastname: Garrick
authors.affiliation: Department of Statistics, Iowa State University, Ames, IA 50011, USA.
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Koehler
authors.affiliation: Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Minick-Bormann
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: James M
authors.initials: JM
authors.lastname: Reecy
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA.
authors.forename: Diane E
authors.initials: DE
authors.lastname: Spurlock
authors.affiliation: Department of Animal Science, Ames, IA 50011, USA. Electronic address: dcbeitz@iastate.edu.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Beitz
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics*; D051048:Diacylglycerol O-Acyltransferase / Q000235:genetics*; D005227:Fatty Acids / Q000032:analysis*; D005992:Glycerol-3-Phosphate O-Acyltransferase / Q000235:genetics*; D050155:Lipogenesis / Q000235:genetics; D008892:Milk / Q000737:chemistry*; D020641:Polymorphism, Single Nucleotide
chemical_list: D005227:Fatty Acids; D005992:Glycerol-3-Phosphate O-Acyltransferase; D051048:Diacylglycerol O-Acyltransferase
keywords: DGAT1; Dairy cow; Haplotype; Milk TAG biosynthesis; Milk fatty acid composition