title: Haloperidol treatment at pre-exposure phase reduces the disturbance of latent inhibition in rats with neonatal ventral hippocampus lesions.
abstract: Animals with neonatal ventral hippocampal lesions develop during or after adolescence abnormal behaviors related to schizophrenia such as anxiety and latent inhibition disruption. The aim of this study was to test whether haloperidol injection prior to pre-exposure session in the latent inhibition test would facilitate latent inhibition. Lesioned animals showed a significant decrease in the number and duration of social interactions, a decrease in the marbles buried, a significant increase in locomotor activity, and a disruption of latent inhibition. In the conditioned taste aversion test, injection of haloperidol produced the recovery of latent inhibition. These findings demonstrate that neonatal lidocaine lesion of the ventral hippocampus can induce behavioral changes related to schizophrenia, and injection of haloperidol, when restricted only to a three-day pre-exposure, is sufficient to facilitate latent inhibition.
authors.affiliation: Lab Pharmacology, Neurobiology & Behavior (URAC-37), Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Ouhaz
authors.affiliation: Lab Pharmacology, Neurobiology & Behavior (URAC-37), Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco.
authors.forename: Saadia
authors.initials: S
authors.lastname: Ba-M'hamed
authors.affiliation: Lab Pharmacology, Neurobiology & Behavior (URAC-37), Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco. Electronic address: mbennis@uca.ma.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Bennis
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D014150:Antipsychotic Agents; D001522:Behavior, Animal; D003213:Conditioning, Psychological; D004195:Disease Models, Animal; D006220:Haloperidol / Q000008:administration & dosage*; D006624:Hippocampus / Q000187:drug effects* / Q000254:growth & development*; D008012:Lidocaine / Q000008:administration & dosage; D009043:Motor Activity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012559:Schizophrenia / Q000139:chemically induced* / Q000517:prevention & control; D012569:Schizotypal Personality Disorder / Q000517:prevention & control; D013649:Taste
chemical_list: D014150:Antipsychotic Agents; D008012:Lidocaine; D006220:Haloperidol
keywords: Anxiety; Anxiété; Conditioned taste aversion; Conditionnement aversif; Hippocampe ventral; Inhibition latente; Latent inhibition; Passive avoidance test; Schizophrenia; Schizophrénie; Social interactions; Ventral hippocampus; Évitement passif