title: Clinical features, risk factors, and treatment experience: a review of 74 patients with ST-segment elevation myocardial infarction complicated by ventricular fibrillation.
abstract: BACKGROUND
  Ventricular fibrillation (VF) is one of the most serious complications of acute myocardial infarction, with a high mortality rate. There is a lack of value of rescue thrombolysis in ST-segment elevation myocardial infarction (STEMI) complicated by VF.
  
  
  OBJECTIVE
  To examine the relationship between risk factors and mortality, and assess the value of rescue thrombolysis in STEMI complicated by VF.
  
  
  METHODS
  A total 74 cases of STEMI complicated by VF were enrolled. The experimental group consisted of 26 patients who underwent rescue thrombolysis, and the control group included 48 cases without rescue thrombolysis. The two groups were compared in terms of demographic and clinical features including gender, age, onset time, blood pressure, patient's history, creatine kinase-MB, infarct area, complications, therapy, and outcomes, including mortality.
  
  
  RESULTS
  The mortality rate of the experimental group was 15.38%, lower than 37.50% of the control group (p < 0.05). The bleeding rate was 34.62% (n = 9) in the experimental group. The risk factors of smoking, shock, and rescue thrombolysis were correlated with mortality of STEMI complicated by VF (p < 0.05 for all): Smoking and shock both were positively correlated with mortality, their regression coefficients/odds ratios (OR) were, respectively, 4606/100,041 and 5552/247,711; the rescue thrombolysis was negatively correlated with mortality, its regression coefficient/OR was -1942/0.143.
  
  
  CONCLUSIONS
  Rescue thrombolysis combined with cardiopulmonary resuscitation and defibrillation is beneficial to patients with STEMI complicated by VF. Smoking, shock upon admission, and lack of rescue thrombolysis were risk factors for mortality in STEMI complicated by VF.
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Quan-Fang
authors.initials: QF
authors.lastname: Chen
authors.affiliation: Department of Cardiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Rui-Xing
authors.initials: RX
authors.lastname: Yin
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Ji-Jin
authors.initials: JJ
authors.lastname: Zhu
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Qi-Bin
authors.initials: QB
authors.lastname: Li
authors.affiliation: Department of Emergency Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Chang
authors.affiliation: Department of Respiratory Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yan-Bi
authors.initials: YB
authors.lastname: Wu
authors.affiliation: Department of Emergency Medicine, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
authors.forename: Edward
authors.initials: E
authors.lastname: Michelson
mesh_terms: D000328:Adult; D000368:Aged; D016887:Cardiopulmonary Resuscitation; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000209:etiology / Q000628:therapy; D012044:Regression Analysis; D012307:Risk Factors; D015912:Thrombolytic Therapy; D014693:Ventricular Fibrillation / Q000209:etiology / Q000401:mortality / Q000628:therapy
keywords: ST-segment elevation myocardial infarction; clinical features; rescue thrombolysis; risk factors; ventricular fibrillation