title: Complete resolution of avascular necrosis of the human femoral head treated with adipose tissue-derived stem cells and platelet-rich plasma.
abstract: We report a case of a 43-year-old man with early stage (stage 1) avascular necrosis (AVN) of the femoral head treated with adipose tissue-derived stem cells (ASCs) and platelet-rich plasma (PRP). ASC-containing stromal vascular fraction was mixed with PRP and hyaluronic acid. This mixture was then injected into the diseased hip under ultrasound guidance. The affected hip was reinjected weekly with additional PRP for 4 weeks. The patient was followed-up with sequential magnetic resonance imaging (MRI) scans at 3, 18, and 21 months after treatment, together with Visual Analogue Scale (VAS) Walking Index, Functional Rating Index, Harris Hip Score, and Range of Motion (ROM) assessments. The patient's severe hip pain was considerably improved at 3 months after treatment, with pain scores, ROM and MRI showing near complete resolution of AVN. Pain scores, ROM and MRI at 18 and 21 months after treatment indicated complete resolution of AVN. This case represents the first evidence of complete resolution of early stage AVN of the hip following treatment with ASCs/PRP.
authors.affiliation: Stems Medical Clinic, Seoul, Republic of Korea.
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Pak
authors.affiliation: Stems Medical Clinic, Seoul, Republic of Korea National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea.
authors.forename: Jung Hun
authors.initials: JH
authors.lastname: Lee
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea.
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Jeon
authors.affiliation: National Leading Research Laboratory, Department of Biological Sciences, Myongji University, Yongin, Republic of Korea sangheelee@mju.ac.kr.
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000328:Adult; D005270:Femur Head / Q000473:pathology*; D005271:Femur Head Necrosis / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D059408:Pain Management / Q000379:methods; D010147:Pain Measurement; D053657:Platelet-Rich Plasma; D016059:Range of Motion, Articular / Q000502:physiology; D033581:Stem Cell Transplantation; D013234:Stem Cells; D016896:Treatment Outcome
chemical_list: D006820:Hyaluronic Acid
keywords: Avascular necrosis of femoral head; hip pain; magnetic resonance imaging; platelet-rich plasma; stem cell therapy