title: [The opportunity to use combined stem cells transplantation for haemopoesis activation in the old and mature laboratory animals under the conditions of ionizing radiation].
abstract: The objective of this work was to study the influence of combined transplantation of stem cells (multypotent mesenchimal stromal and haemopoetic stem cells) on the haemopoesis of old and mature laboratory animals under the condition of ionizing radiation. The result of the experiment shows that under physiological conditions the combined transplantation brings the erithropoesis activation, under the ionizing radiation conditions it brings the erythroid and granulocytopoesis activation. Moreover the combined MMSC and HSC transplantation gives cytoprotective action on the myeloid tissue due to decrease of cyto genically changed cells in the mature animals under the condition of ionizing radiation, but in the old animals this effect can be seen even under physiological condition. Combined transplantation of MMSC and GSC can be used in the mature and old laboratory animals under the conditions of ionising radiation for the haemopoesis activation.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Grebnev
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Maklakova
authors.forename: A P
authors.initials: AP
authors.lastname: Iastrebov
mesh_terms: D000367:Age Factors; D000375:Aging / Q000502:physiology / Q000528:radiation effects; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology / Q000528:radiation effects; D019610:Cytoprotection / Q000502:physiology / Q000528:radiation effects; D006410:Hematopoiesis / Q000502:physiology / Q000528:radiation effects; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D051379:Mice; D023421:Models, Animal; D011839:Radiation, Ionizing; D013997:Time Factors