title: Individualized diffeomorphic mapping of brains with large cortical infarcts.
abstract: Whole brain mapping of stroke patients with large cortical infarcts is not trivial due to the complexity of infarcts' anatomical location and appearance in magnetic resonance image. In this study, we proposed an individualized diffeomorphic mapping framework for solving this problem. This framework is based on our recent work of large deformation diffeomorphic metric mapping (LDDMM) in Du et al. (2011) and incorporates anatomical features, such as sulcal/gyral curves, cortical surfaces, brain intensity image, and masks of infarcted regions, in order to align a normal brain to the brain of stroke patients. We applied this framework to synthetic data and data of stroke patients and validated the mapping accuracy in terms of the alignment of gyral/sulcal curves, sulcal regions, and brain segmentation. Our results revealed that this framework provided comparable mapping results for stroke patients and healthy controls, suggesting the importance of incorporating individualized anatomical features in whole brain mapping of brains with large cortical infarcts.
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore.
authors.forename: Hock Wei
authors.initials: HW
authors.lastname: Soon
authors.affiliation: Department of Biomedical Engineering, National University of Singapore, Singapore; Clinical Imaging Research Center, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, the Agency for Science, Technology and Research, Singapore. Electronic address: bieqa@nus.edu.sg.
authors.forename: Anqi
authors.initials: A
authors.lastname: Qiu
mesh_terms: D000368:Aged; D000465:Algorithms; D001921:Brain / Q000473:pathology* / Q000502:physiology; D020520:Brain Infarction / Q000473:pathology*; D001931:Brain Mapping; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D011336:Probability; D012984:Software; D020521:Stroke / Q000503:physiopathology*
keywords: Brain mapping; Cortical infarct; Diffeomorphic mapping; Stroke