title: Image-guided radiotherapy for cardiac sparing in patients with left-sided breast cancer.
abstract: Patients with left-sided breast cancer are at risk of cardiac toxicity because of cardiac irradiation during radiotherapy with the conventional 3-dimensional conformal radiotherapy technique. In addition, many patients may receive chemotherapy prior to radiation, which may damage the myocardium and may increase the potential for late cardiac complications. New radiotherapy techniques such as intensity-modulated radiotherapy (IMRT) may decrease the risk of cardiac toxicity because of the steep dose gradient limiting the volume of the heart irradiated to a high dose. Image-guided radiotherapy (IGRT) is a new technique of IMRT delivery with daily imaging, which may further reduce excessive cardiac irradiation. Preliminary results of IGRT for cardiac sparing in patients with left-sided breast cancer are promising and need to be investigated in future prospective clinical studies.
authors.affiliation: Department of Radiation Oncology, Centre Val d'Aurelle , Montpellier , France.
authors.forename: Claire
authors.initials: C
authors.lastname: Lemanski
authors.affiliation: Department of Radiation Oncology, University of Nice , Nice , France.
authors.forename: Juliette
authors.initials: J
authors.lastname: Thariat
authors.affiliation: Department of Radiation Oncology, Louisiana State University , Shreveport, LA , USA.
authors.forename: Federico L
authors.initials: FL
authors.lastname: Ampil
authors.affiliation: Department of Radiation Oncology, Howard University , Washington, DC , USA.
authors.forename: Satya
authors.initials: S
authors.lastname: Bose
authors.affiliation: Department of Radiation Oncology, Lindenhofspital , Bern , Switzerland.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Vock
authors.affiliation: Michael D. Watchtel Cancer Center , Oshkosh, WI , USA.
authors.forename: Rick
authors.initials: R
authors.lastname: Davis
authors.affiliation: Department of Radiation Oncology, University of West Virginia , Morgantown, WV , USA.
authors.forename: Alexander
authors.initials: A
authors.lastname: Chi
authors.affiliation: Department of Radiation Oncology, Medicine and Radiation Oncology PA , San Antonio, TX , USA.
authors.forename: Suresh
authors.initials: S
authors.lastname: Dutta
authors.affiliation: Department of Radiation Oncology, Richard A. Henson Institute , Salisbury, MD , USA.
authors.forename: William
authors.initials: W
authors.lastname: Woods
authors.affiliation: Department of Radiation Oncology, Akron City Hospital , Akron, OH , USA.
authors.forename: Anand
authors.initials: A
authors.lastname: Desai
authors.affiliation: Florida Radiation Oncology Group, Department of Radiation Oncology , Jacksonville, FL , USA.
authors.forename: Juan
authors.initials: J
authors.lastname: Godinez
authors.affiliation: Department of Radiation Oncology, Marshfield Clinic , Marshfield, WI , USA.
authors.forename: Ulf
authors.initials: U
authors.lastname: Karlsson
authors.affiliation: Department of Radiation Oncology, University of Arizona , Tucson, AZ , USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Mills
authors.affiliation: Department of Radiation Oncology, Howard University , Washington, DC , USA.
authors.forename: Nam Phong
authors.initials: NP
authors.lastname: Nguyen
authors.affiliation: Department of Radiation Oncology, University of Martinique Hospital , Martinique , France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
keywords: IGRT; breast cancer; cardiac toxicity; left breast