title: Longitudinal changes in maternal corin and mid-regional proatrial natriuretic peptide in women at risk of pre-eclampsia.
abstract: OBJECTIVE
  Corin, an atrial natriuretic peptide-converting enzyme, has been found to promote trophoblast invasion and spiral artery remodeling. Yet, elevated maternal plasma atrial natriuretic peptide (ANP) and corin levels have been reported in pregnancies complicated by pre-eclampsia (PE). The aim of this study was to investigate longitudinal changes in maternal plasma levels of corin and mid-regional proatrial natriuretic peptide (MR-PANP) in pregnancies that develop PE and gestational hypertension (GH).
  
  
  METHODS
  This was a nested case-control study drawn from a larger prospective longitudinal study in singleton pregnancies identified as being at high risk for PE by screening at 11 + 0 to 13 + 6 weeks' gestation. Blood samples were taken every 4 weeks until delivery. Values were compared in pregnancies that developed preterm PE (requiring delivery before 37 weeks' gestation), term PE, GH and those that remained normotensive.
  
  
  RESULTS
  A total of 471 samples were analyzed from 122 women, including 85 that remained normotensive, 12 that developed GH, 13 term PE and 12 preterm PE. In the normotensive group, log10 corin levels were associated with gestational age (P < 0.01), whereas log10 MR-PANP levels were not. In the preterm-PE group, compared with the normotensive group, corin was significantly lower until 20 weeks' gestation (P = 0.001). In the GH and term-PE groups, corin did not differ significantly from the normotensive group (P = 0.637 and P = 0.161, respectively). Compared with the normotensive group, MR-PANP levels were significantly higher in the pregnancies that developed preterm PE and GH (P = 0.046 and P = 0.019, respectively), but not term PE (P = 0.467).
  
  
  CONCLUSIONS
  Maternal-plasma corin and MR-PANP could potentially be useful biomarkers for the prediction of preterm PE.
authors.affiliation: Department of Fetal Medicine, St George's University of London, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Khalil
authors.forename: N
authors.initials: N
authors.lastname: Maiz
authors.forename: R
authors.initials: R
authors.lastname: Garcia-Mandujano
authors.forename: M
authors.initials: M
authors.lastname: Elkhouli
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood / Q000503:physiopathology; D008137:Longitudinal Studies; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy; D012307:Risk Factors; D012697:Serine Endopeptidases / Q000097:blood*
chemical_list: D009320:Atrial Natriuretic Factor; C119812:CORIN protein, human; D012697:Serine Endopeptidases
keywords: atrial natriuretic peptide; blood pressure; corin; gestational hypertension; longitudinal; pre-eclampsia; pregnancy screening