title: Helicobacter pylori infection, gastrin and cyclooxygenase-2 in gastric carcinogenesis.
abstract: Gastric cancer is one of the most frequent neoplasms and a main cause of death worldwide, especially in China and Japan. Numerous epidemiological, animal and experimental studies support a positive association between chronic Helicobacter pylori (H. pylori) infection and the development of gastric cancer. However, the exact mechanism whereby H. pylori causes gastric carcinogenesis remains unclear. It has been demonstrated that expression of cyclooxygenase-2 (COX-2) is elevated in gastric carcinomas and in their precursor lesions. In this review, we present the latest clinical and experimental evidence showing the role of gastrin and COX-2 in H. pylori-infected patients and their possible association with gastric cancer risk.
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Shao
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Sun
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Li
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Yun Shao, Kun Sun, Wei Xu, Xiao-Lin Li, Wei-Hao Sun, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Wei-Hao
authors.initials: WH
authors.lastname: Sun
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D005755:Gastrins / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000201:enzymology / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects / Q000472:pathogenicity*; D006801:Humans; D012307:Risk Factors; D015398:Signal Transduction; D013270:Stomach / Q000187:drug effects / Q000201:enzymology* / Q000382:microbiology* / Q000473:pathology; D013274:Stomach Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000235:genetics / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D016588:Anticarcinogenic Agents; D052246:Cyclooxygenase 2 Inhibitors; D005755:Gastrins; D051546:Cyclooxygenase 2
keywords: Cyclooxygenase-2; Gastric cancer; Gastrin; Helicobacter pylori