title: Primary squamous cell carcinoma of the stomach: A case report.
abstract: Pure squamous cell carcinoma (SCC) of the stomach is rare and resembles SCC arising elsewhere in the body. The pathogenesis of SCC remains unclear and controversial. At present, <100 cases of primary SCC of the stomach have been reported. The current study presents a case of SCC of the stomach in a 61-year-old male. Total gastrectomy was performed and a 7.0×6.7×4.5-cm tumor with a superiorly located ulcer was identified in the cardia. Upon histological examination, a moderately-differentiated SCC was observed. Tumor cells extended to the serosa, and the perigastric regional lymph node was also involved. No evidence of human papillomavirus (HPV) or Epstein-Barr virus (EBV) infection was identified using a DNA microarray andin situhybridization, respectively. A post-operative computed tomography scan four months after the gastrectomy revealed tumor recurrence and dissemination of the tumor to the jejunum and pancreas. The patient succumbed to the disease six months later despite the administration of low-dose adjuvant 5-fluorouracil/cisplatin chemotherapy.
authors.affiliation: Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea.
authors.forename: Sun Hwi
authors.initials: SH
authors.lastname: Hwang
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Lee
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea.
authors.forename: Kyungbin
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea ; Department of Pathology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, Republic of Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea ; Department of Pathology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, Republic of Korea.
authors.forename: Jee Yeon
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea ; Department of Pathology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, Republic of Korea.
authors.forename: Mee Young
authors.initials: MY
authors.lastname: Sol
authors.affiliation: Department of Pathology, Pusan National University Yangsan Hospital, Yangsan, Gyeongsangnam-do 626-770, Republic of Korea ; Department of Pathology, School of Medicine, Pusan National University, Yangsan, Gyeongsangnam-do 626-870, Republic of Korea.
authors.forename: Kyung Un
authors.initials: KU
authors.lastname: Choi
keywords: squamous cell carcinoma; stomach