title: The interaction between menstrual cycle, Tumour Necrosis Factor alpha receptors and sex hormones in healthy non-obese women--results from an observational study.
abstract: There is growing evidence that TNF-alpha and its two receptors play an important role in hormonal regulation, metabolism, inflammation and cancer. The biological effects of TNF-alpha are mediated by two receptors, p55 and p75. The aim of this study was to analyze serum concentrations of p55 and p75 and hormonal status in healthy women during the normal menstrual cycle. Eight women aged 20-22 with regular menstrual cycles were scheduled for examination on 3(rd) , 8(th) , 14(th) and 25(th) day of their menstrual cycle. We only observed a positive correlation of p75 subunit with prolactin level (correlation coefficient 0.417; p=0.0116) and negative correlation with insulin level (correlation coefficient -0.35; p=0.032) and HOMAIR insulin resistance index correlation coefficient 0.39; p=0.0185). Furthermore, a negative correlation of p55/p75 ratio with prolactin (correlation coefficient -0.42; p=0.0101) and a positive correlations of p55/p75 ratio with insulin level (correlation coefficient 0.43; p=0.008) and HOMAIR insulin resistance factor correlation coefficient 0.45; p=0.0065) were found.
authors.affiliation: Department of Mother's and Child's Health, University of Medical Sciences, Poznań, Poland.
authors.forename: Paweł
authors.initials: P
authors.lastname: Rzymski
authors.affiliation: Department of Educational Medicine, University of Medical Sciences, Poznań, Poland; Higher Vocational State School, Kalisz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Wilczak
authors.affiliation: Department of Mother's and Child's Health, University of Medical Sciences, Poznań, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Malinger
authors.affiliation: Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland;Faculty of Pedagogy and Psychology, University of Economics and Innovation, Lublin, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Włoszczak-Szubzda
authors.affiliation: Department of Health Informatics and Statistics, Institute of Rural Health, Lublin, Poland; Faculty of Pedagogy and Psychology, University of Economics and Innovation, Lublin, Poland.
authors.forename: Mirosław Jerzy
authors.initials: MJ
authors.lastname: Jarosz
authors.affiliation: Department of Mother's and Child's Health, University of Medical Sciences, Poznań, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Opala
mesh_terms: D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008597:Menstrual Cycle / Q000502:physiology*; D011388:Prolactin / Q000378:metabolism*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism*; D053319:Tumor Necrosis Factor Decoy Receptors / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D055815:Young Adult
chemical_list: D007328:Insulin; D047888:Receptors, Tumor Necrosis Factor, Type I; D053319:Tumor Necrosis Factor Decoy Receptors; D014409:Tumor Necrosis Factor-alpha; C069521:recombinant human tumor necrosis factor-binding protein-1; D011388:Prolactin