title: Differential susceptible loci expression in keloid and hypertrophic scars in the Chinese Han population.
abstract: BACKGROUND
  Hypertrophic scars (HSs) and keloids (KDs) are commonly seen as 2 different diseases. We aimed to find potential genes associated with KD and HS formation.
  
  
  METHODS
  We selected 4 single-nucleotide polymorphisms (SNPs) (based on the whole genome resequencing we have done) for replication in 71 KDs and 50 HSs using the Sequenom Massarray system.
  
  
  RESULTS
  We found evidence of significant association at rs181924090, P = 0.0075; rs183178644, P = 0.0151; and rs151091483, P = 0.0073. However, at rs141156594, there was no significant association between KD and HS (P = 0.7893).
  
  
  CONCLUSIONS
  rs181924090 (11p15.5, SIRT3), rs151091483 (17p13.1, MYH8), and rs183178644 (6p25.3, HUS1B) are new potential SNPs associated with KD formation, especially closely related to tumor behaviors as KD is, whereas rs141156594 (18q22.2, RTTN) is a new SNP involved in the extracellular matrix formation in wound healing.
authors.affiliation: From the *Institute of Plastic Surgery, XiJing Hospital, the Fourth Military Medical University, Xi'an, Shanxi; †Medical School of Chinese PLA, Beijing; and ‡Department of Burn and Plastic Surgery, and §Wound Healing and Cell Biology Laboratory, Burns Institute, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Teng
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Minliang
authors.initials: M
authors.lastname: Chen
authors.forename: Kui
authors.initials: K
authors.lastname: Ma
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.forename: Tongtong
authors.initials: T
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D002352:Carrier Proteins / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002681:China; D017439:Cicatrix, Hypertrophic / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007627:Keloid / Q000208:ethnology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018995:Myosin Heavy Chains / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics; D056566:Sirtuin 3 / Q000235:genetics; D014945:Wound Healing / Q000235:genetics*; D055815:Young Adult
chemical_list: C488660:ADGRG6 protein, human; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D005819:Genetic Markers; C462949:HUS1B protein, human; C488292:MYH8 protein, human; C576561:RTTN protein, human; D043562:Receptors, G-Protein-Coupled; C466093:SIRT3 protein, human; D056566:Sirtuin 3; D018995:Myosin Heavy Chains