title: New developments in insulin therapy for type 2 diabetes.
abstract: Insulin has classically been considered a treatment of last resort for individuals with type 2 diabetes, delayed until all other efforts by the patient and healthcare provider have failed. Recent treatment guidelines recommend the use of insulin, in particular basal insulin, as part of a treatment regimen earlier in the disease process. Many patients are reticent about initiating insulin, so therapies that allow insulin treatment to be more tailored to individual needs are likely to result in greater acceptance and patient adherence with therapy. To meet this need, a range of insulin products are in development that aim to increase absorption rate or prolong the duration of action, reduce peak variability and weight gain associated with insulin treatment, and offer alternative delivery methods. This review describes insulin products in clinical development, new combination therapies, and new devices for insulin delivery.
authors.affiliation: Department of Diabetes, Endocrinology and Metabolism, Billings Clinic, Billings, Mont. Electronic address: csorli@billingsclinic.org.
authors.forename: Christopher
authors.initials: C
authors.lastname: Sorli
mesh_terms: D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000523:psychology; D019468:Disease Management; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D016903:Drug Monitoring; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D007267:Injections / Q000379:methods / Q000523:psychology; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D055118:Medication Adherence / Q000523:psychology; D012646:Self Administration; D035703:Therapies, Investigational; D015430:Weight Gain / Q000187:drug effects
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
keywords: Basal insulin; Insulin; Type 2 diabetes