title: Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis.
abstract: Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. Replication of results, however, has been absent in all but a few cases, and the range of control samples has been limited. If progress toward clinical translation is to continue, the specific biomarker needs of ALS, which differ from those of other neurodegenerative disorders, as well as the challenges inherent to longitudinal ALS biomarker cohorts, must be understood. Appropriate application of multimodal approaches, international collaboration, presymptomatic studies, and biomarker integration into future therapeutic trials are among the essential priorities going forward.
authors.affiliation: Oxford University, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, West Wing Level 3, Oxford, OX3 9DU, UK.
authors.forename: Martin R
authors.initials: MR
authors.lastname: Turner
authors.forename: Michael
authors.initials: M
authors.lastname: Benatar
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans
chemical_list: D015415:Biomarkers
keywords: biomarker; motor neuron disease; neurochemistry; neuroimaging; trial