title: Neuroprotective effects of lipoxin A4 in central nervous system pathologies.
abstract: Many diseases of the central nervous system are characterized and sometimes worsened by an intense inflammatory response in the affected tissue. It is now accepted that resolution of inflammation is an active process mediated by a group of mediators that can act in synchrony to switch the phenotype of cells, from a proinflammatory one to another that favors the return to homeostasis. This new genus of proresolving mediators includes resolvins, protectins, maresins, and lipoxins, the first to be discovered. In this short review we provide an overview of current knowledge into the cellular and molecular interactions of lipoxins in diseases of the central nervous system in which they appear to facilitate the resolution of inflammation, thus exerting a neuroprotective action.
authors.affiliation: Departmento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88049-900 Florianópolis, SC, Brazil.
authors.forename: Alessandra Cadete
authors.initials: AC
authors.lastname: Martini
authors.affiliation: Departmento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88049-900 Florianópolis, SC, Brazil.
authors.forename: Stefânia
authors.initials: S
authors.lastname: Forner
authors.affiliation: Centro de Inovação e Ensaios Pré-Clínicos (CIEnP), Av. Luiz Boiteux Piazza, 1302-Canasvieiras, 88056-000 Florianópolis, SC, Brazil.
authors.forename: Allisson Freire
authors.initials: AF
authors.lastname: Bento
authors.affiliation: Departmento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina (UFSC), Campus Universitário, Trindade, 88049-900 Florianópolis, SC, Brazil.
authors.forename: Giles Alexander
authors.initials: GA
authors.lastname: Rae
mesh_terms: D000818:Animals; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D044045:Lipoxins / Q000627:therapeutic use*; D018696:Neuroprotective Agents / Q000627:therapeutic use*
chemical_list: D044045:Lipoxins; D018696:Neuroprotective Agents; C040527:lipoxin A4