title: Continuous flow left ventricular pump support and its effect on regional left ventricular wall stress: finite element analysis study.
abstract: Left ventricular assist device (LVAD) support unloads left ventricular (LV) pressure and volume and decreases wall stress. This study investigated the effect of systematic LVAD unloading on the 3-dimensional myocardial wall stress by employing finite element models containing layered fiber structure, active contractility, and passive stiffness. The HeartMate II(®) (Thoratec, Inc., Pleasanton, CA) was used for LV unloading. The model geometries and hemodynamic conditions for baseline (BL) and LVAD support (LVsupport) were acquired from the Penn State mock circulatory cardiac simulator. Myocardial wall stress of BL was compared with that of LVsupport at 8,000, 9,000, 10,000 RPM, providing mean pump flow (Q(mean)) of 2.6, 3.2, and 3.7 l/min, respectively. LVAD support was more effective at unloading during diastole as compared to systole. Approximately 40, 50, and 60% of end-diastolic wall stress reduction were achieved at Q(mean) of 2.6, 3.2, and 3.7 l/min, respectively, as compared to only a 10% reduction of end-systolic wall stress at Q(mean) of 3.7 l/min. In addition, there was a stress concentration during systole at the apex due to the cannulation and reduced boundary motion. This modeling study can be used to further understand optimal unloading, pump control, patient management, and cannula design.
authors.affiliation: Division of Artificial Organs, Department of Surgery, College of Medicine, The Pennsylvania State University, 500 University Drive, Hershey, PA, 17033, USA, jcysyk@hmc.psu.edu.
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Jhun
authors.forename: Kay
authors.initials: K
authors.lastname: Sun
authors.forename: Joshua P
authors.initials: JP
authors.lastname: Cysyk
mesh_terms: D001696:Biomechanical Phenomena / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D020342:Finite Element Analysis; D006333:Heart Failure / Q000601:surgery; D006352:Heart Ventricles; D006353:Heart-Assist Devices; D006801:Humans; D008955:Models, Cardiovascular; D016277:Ventricular Function, Left / Q000502:physiology*