title: Adiponectin receptor 1 (ADIPOR1) rs1342387 polymorphism and risk of cancer: a meta-analysis.
abstract: Many studies have indicated possible associations between a polymorphism of adiponectin receptor 1 (ADIPOR1) rs1342387 and risk of cancer, but contradictory results have been reported. The main aim of this study was to draw a reliable conclusion about the relationship between the rs1342387 polymorphism and cancer incidence, by conducting a literature search of Pubmed, Embase, Wanfang and Cochrane libraries. Eleven studies including 3, 738 cases and 4, 748 controls were identified in this meta-analysis. The ADIPOR1 rs1342387 polymorphism was associated with risk of colorectal cancer for all genetic comparison models (GG vs AA, OR: 1.44, 95%CI: 1.21 -1.70; G carriers vs A carriers, OR: 1.23, 95%CI: 1.11 -1.36; dominant model, OR: 1.28, 95%CI: 1.10 -1.49 and recessive model, OR: 1.31, 95%CI: 1.12 -1.55). Stratified by ethnicity, the rs1342387 polymorphism was significantly associated with risk of colorectal cancer in Asian ancestry for all genetic comparison models (GG vs AA, OR: 1.56, 95%CI: 1.26-1.92; G carriers vs. A carriers OR: 1.30, 95%CI: 1.18 -1.43; dominant model OR: 1.31, 95%CI: 1.08 -1.60 and recessive model OR: 1.44, 95%CI: 1.26 -1.64), but not in Caucasian or mixed (Caucasian mainly) groups. In summary, the ADIPOR1 rs1342387 polymorphism is significantly associated with risk of colorectal cancer among individuals of Asian ancestry.
authors.affiliation: Department of Breast Diseases, The Second Hospital of Shandong University, Jinan, China E-mail : zhounannan@medmail.com.cn.
authors.forename: Li-Xiang
authors.initials: LX
authors.lastname: Yu
authors.forename: Nan-Nan
authors.initials: NN
authors.lastname: Zhou
authors.forename: Li-Yuan
authors.initials: LY
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Zhong-Bing
authors.initials: ZB
authors.lastname: Ma
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yu
mesh_terms: D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D054419:Receptors, Adiponectin / Q000235:genetics*; D012307:Risk Factors
chemical_list: C475418:ADIPOR1 protein, human; D054419:Receptors, Adiponectin