title: EMT in cervical cancer: its role in tumour progression and response to therapy.
abstract: The prognosis of cervical patients significantly decreases as the cancer metastasizes to other parts of the body. The epithelial to mesenchymal transition (EMT) plays an important role in cervical cancer progression and metastasis. Recurrence is the primary cause of the increased number of deaths due to cervical cancer. Oncogenes, such as AEG1, Sam-68, FTS and miR-361-5p, induce EMT in cervical cancer. Tumour suppressors, such as LMX-1, SFRP1, klotho, and miR-155, suppress EMT in cervical cancer. Factors such as hypoxia, the radiation dose, cytokines, proteins, transcription factors, and signalling pathways also play an important role in the induction, progression and maintenance of EMT in cervical cancer. Overall, this review describes a wide range of factors with potential roles in EMT that have been identified to date, and this information could be important for the development of new and more effective therapeutics that ameliorate the negative impact of cervical pathogenesis via EMT.
authors.affiliation: Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia 110 025, New Delhi.
authors.forename: Rehana
authors.initials: R
authors.lastname: Qureshi
authors.affiliation: IREBS UMR7242, CNRS, University of Strasbourg, ESBS API Pole, Boulevard Sébastien Brandt, BP10413, Illkirch Cedex F-67412, France.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Arora
authors.affiliation: Genome Biology Lab, Department of Biosciences, Jamia Millia Islamia 110 025, New Delhi. Electronic address: rizvi_ma@yahoo.com.
authors.forename: M A
authors.initials: MA
authors.lastname: Rizvi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology*; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents
keywords: Cervical cancer; Epithelial Mesenchymal Transition; Mesenchymal transition (EMT); Oncogene; Therapeutics; Tumour-suppressor