title: Sender-receiver systems and applying information theory for quantitative synthetic biology.
abstract: Sender-receiver (S-R) systems abound in biology, with communication systems sending information in various forms. Information theory provides a quantitative basis for analysing these processes and is being applied to study natural genetic, enzymatic and neural networks. Recent advances in synthetic biology are providing us with a wealth of artificial S-R systems, giving us quantitative control over networks with a finite number of well-characterised components. Combining the two approaches can help to predict how to maximise signalling robustness, and will allow us to make increasingly complex biological computers. Ultimately, pushing the boundaries of synthetic biology will require moving beyond engineering the flow of information and towards building more sophisticated circuits that interpret biological meaning.
authors.affiliation: EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
authors.forename: Diego
authors.initials: D
authors.lastname: Barcena Menendez
authors.affiliation: EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
authors.forename: Vivek Raj
authors.initials: VR
authors.lastname: Senthivel
authors.affiliation: Department of Life Sciences, Imperial College London, London SW7 2AZ, UK. Electronic address: m.isalan@imperial.ac.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Isalan
mesh_terms: D000818:Animals; D002450:Cell Communication; D004058:Diffusion; D006801:Humans; D007257:Information Theory; D011506:Proteins / Q000032:analysis; D015398:Signal Transduction; D058615:Synthetic Biology / Q000379:methods*
chemical_list: D011506:Proteins