title: Asymmetric catalysis with short-chain peptides.
abstract: Within this review article we describe recent developments in asymmetric catalysis with peptides. Numerous peptides have been established in the past two decades that catalyze a wide variety of transformations with high stereoselectivities and yields, as well as broad substrate scope. We highlight here catalytically active peptides, which have addressed challenges that had thus far remained elusive in asymmetric catalysis: enantioselective synthesis of atropoisomers and quaternary stereogenic centers, regioselective transformations of polyfunctional substrates, chemoselective transformations, catalysis in-flow and reactions in aqueous environments.
authors.affiliation: Laboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
authors.forename: Bartosz
authors.initials: B
authors.lastname: Lewandowski
authors.affiliation: Laboratory of Organic Chemistry, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland. Electronic address: Helma.Wennemers@org.chem.ethz.ch.
authors.forename: Helma
authors.initials: H
authors.lastname: Wennemers
mesh_terms: D000215:Acylation; D000818:Animals; D055162:Biocatalysis; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism
chemical_list: D001688:Biological Products; D004852:Epoxy Compounds; D010455:Peptides; D013438:Sulfhydryl Compounds