title: HLA-B*13:01 is associated with salazosulfapyridine-induced drug rash with eosinophilia and systemic symptoms in Chinese Han population.
abstract: OBJECTIVE
  Salazosulfapyridine (SASP) frequently causes several adverse reactions, such as drug rash with eosinophilia and systemic symptoms (DRESS). This study aims to assess whether there is an association between SASP-induced DRESS and HLA-A, -B and -C alleles in the Chinese Han population.
  
  
  METHODS
  We performed an association study of six subjects with SASP-induced DRESS, 30 SASP-tolerant patients and 283 general subjects from the human MHC database, all of whom are Han Chinese.
  
  
  RESULTS
  The frequency of the SASP-induced DRESS patients carrying the HLA-B*13:01 allele is 66.67% (4/6). It is significantly higher compared with the general Chinese Han population (15.19%, 43/283; odds ratio: 11.16; p = 0.007) or with the SASP-tolerant patients (13.33%, 4/30; odds ratio: 13.00; p = 0.004).
  
  
  CONCLUSIONS
  These findings show for the first time that in the Chinese Han population, HLA-B*13:01 is associated with SASP-induced DRESS. HLA-B*13:01 might serve as a potential genetic marker for reducing the prevalence of SASP-induced DRESS.
authors.affiliation: Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Fanping
authors.initials: F
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Gu
authors.forename: Lirong
authors.initials: L
authors.lastname: Zhang
authors.forename: Jiekun
authors.initials: J
authors.lastname: Xuan
authors.forename: Heng
authors.initials: H
authors.lastname: Luo
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Qinyuan
authors.initials: Q
authors.lastname: Zhu
authors.forename: Sijia
authors.initials: S
authors.lastname: Yan
authors.forename: Sheng-an
authors.initials: SA
authors.lastname: Chen
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Cao
authors.forename: Jinhua
authors.initials: J
authors.lastname: Xu
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Xing
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Luo
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D003875:Drug Eruptions / Q000235:genetics; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics*; D004802:Eosinophilia / Q000139:chemically induced* / Q000235:genetics; D005076:Exanthema / Q000139:chemically induced* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D059908:HLA-B13 Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012460:Sulfasalazine / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D059908:HLA-B13 Antigen; D012460:Sulfasalazine
keywords: HLA-B*13:01; Han Chinese; SASP; cutaneous adverse drug reactions; salazosulfapyridine