title: Kikuchi-Fujimoto disease: report of 4 cases and review of the literature.
abstract: BACKGROUND
  Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign disease of unknown origin predominantly affecting young women and presenting in the form of cervical lymphadenopathy and/or prolonged fever.
  
  
  METHODS
  The authors report 4 cases of Kikuchi-Fujimoto disease diagnosed in the Internal Medicine Department of Ibn Sina university hospital in Rabat between 2009 and 2010.
  
  
  RESULTS
  These 4 women with a mean age of 27±8.6years [16-37] were admitted with febrile syndrome and cervical lymphadenopathy. The diagnosis was based on histological examination of a lymph node biopsy. The disease was associated with systemic lupus erythematosus in one case and actinomycosis in another case. A favourable course was observed in response to corticosteroid therapy in two patients, antibiotic therapy in one patient and antipyretic treatment alone in the fourth patient.
  
  
  CONCLUSIONS
  In the light of these four cases, the authors discuss the diagnostic difficulties, the modalities of treatment of Kikuchi-Fujimoto disease and its clinical course.
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco. Electronic address: l.lamzaf@live.fr.
authors.forename: L
authors.initials: L
authors.lastname: Lamzaf
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Harmouche
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Maamar
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Adnaoui
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco.
authors.forename: M
authors.initials: M
authors.lastname: Aouni
authors.affiliation: Service de médecine interne, CHU Ibn Sina Rabat, Rabat Institut, rue Lamfadel Cherkaoui, BP 6527, Rabat, Morocco.
authors.forename: Z
authors.initials: Z
authors.lastname: Tazi Mezalek
mesh_terms: D000196:Actinomycosis / Q000150:complications; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D058633:Antipyretics / Q000627:therapeutic use; D044963:Biopsy, Fine-Needle; D005260:Female; D005334:Fever / Q000209:etiology; D005938:Glucocorticoids / Q000627:therapeutic use; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008198:Lymph Nodes / Q000473:pathology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D058633:Antipyretics; D005938:Glucocorticoids
keywords: Actinomycosis; Kikuchi-Fujimoto disease; Necrotizing lymphadenitis; Systemic lupus erythematosus