title: Twists and turns: a scientific journey.
abstract: In this perspective I look back on the twists and turns that influenced the direction of my scientific career over the past 40 years. From my early ambition to be a chemist to my training in Philadelphia and Bethesda as a molecular biologist, I benefited enormously from generous and valuable mentoring. In my independent career in Philadelphia and Princeton, I was motivated by a keen interest in the changes in gene expression that direct the development of the mammalian embryo and inspired by the creativity and energy of my students, fellows, and research staff. After twelve years as President of Princeton University, I have happily returned to the faculty of the Department of Molecular Biology.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544; email: smt@princeton.edu.
authors.forename: Shirley M
authors.initials: SM
authors.lastname: Tilghman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002170:Canada; D016386:Chromosome Walking; D047108:Embryonic Development / Q000235:genetics; D005136:Eye Proteins / Q000235:genetics / Q000266:history; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D049673:History, 20th Century; D049674:History, 21st Century; D018398:Homeodomain Proteins / Q000235:genetics / Q000266:history; D006801:Humans; D051379:Mice; D008967:Molecular Biology / Q000266:history*; D008969:Molecular Sequence Data; D009316:National Institutes of Health (U.S.); D009515:New Jersey; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors / Q000235:genetics / Q000266:history; D012326:RNA Splicing; D062085:RNA, Long Noncoding / Q000235:genetics / Q000266:history; D012097:Repressor Proteins / Q000235:genetics / Q000266:history; D014481:United States; D014495:Universities / Q000266:history*; D000509:alpha-Fetoproteins / Q000235:genetics / Q000266:history; D055544:beta-Globins / Q000235:genetics / Q000266:history
chemical_list: D005136:Eye Proteins; C094335:H19 long non-coding RNA; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; C000605732:Pax6 protein, mouse; D062085:RNA, Long Noncoding; D012097:Repressor Proteins; D000509:alpha-Fetoproteins; D055544:beta-Globins
keywords: H19; embryonic development; gene structure and expression; genomic imprinting; genomics; mouse genetics; α-fetoprotein