title: [Light pollution, desynchronosis and aging: the state of problem and solutions].
abstract: The effect of different light conditions (constant illumination, light deprivation, the standard regime of lighting and natural for Northwest Russia lighting in different seasons of the annual cycle) on indicators of biological age and homeostasis, the development of age-related pathology, oncogenesis and longevity of rats was investigated. Exposure to constant light on the studied parameters was evaluated at different ages--antenatal, early and late postnatal period. The data about influences of substances and hormones of pineal gland on biomarkers of aging, homeostasis, spontaneous oncogenesis and longevity in experimental animals was obtained. It has been established that the light pollution and disturbance of photoperiod lead to desynchronosys and as a result to premature aging of the organism and age associated diseases. Ways of preventing accelerated aging were outlined.
authors.forename: I A
authors.initials: IA
authors.lastname: Vinogradova
authors.forename: V A
authors.initials: VA
authors.lastname: Iliukha
authors.forename: E A
authors.initials: EA
authors.lastname: Khizhkin
authors.forename: L B
authors.initials: LB
authors.lastname: Uzenbaeva
authors.forename: T N
authors.initials: TN
authors.lastname: Il'ina
authors.forename: A V
authors.initials: AV
authors.lastname: Bukalev
authors.forename: A I
authors.initials: AI
authors.lastname: Goranskiĭ
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Matveeva
authors.forename: V D
authors.initials: VD
authors.lastname: Iunash
authors.forename: T A
authors.initials: TA
authors.lastname: Lotosh
mesh_terms: D000375:Aging / Q000502:physiology / Q000528:radiation effects; D019588:Aging, Premature / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D006801:Humans; D008027:Light / Q000009:adverse effects*; D008029:Lighting / Q000009:adverse effects / Q000379:methods; D008136:Longevity / Q000528:radiation effects; D008550:Melatonin / Q000378:metabolism*; D023421:Models, Animal; D018462:Photobiology / Q000379:methods; D017440:Photoperiod; D051381:Rats; D018570:Risk Assessment; D012307:Risk Factors; D012426:Russia; D012621:Seasons; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D008550:Melatonin