title: [Sensitivity of nosocomial purulent-septic infection causative agents to disinfection agents and antibiotics].
abstract: OBJECTIVE
  Study the sensitivity of nosocomial purulent-septic infection (PSI) causative agents to disinfectants (DA) and antibiotics (AB).
  
  
  METHODS
  Sensitivity to DA and AB of 209 PSI causative agent strains isolated from patients and the environment of 2 obstetric and 3 surgical hospitals was studied in 2009-2011. Sensitivity to DA of 94 strains and to AB of 189 strains of Pseudomonas aeruginosa isolated from patients with signs of PSI of reanimation and intensive therapy and surgical departments of a multi-field hospital was studied in 2012. Sensitivity to DA was determined on test-surfaces and in solution according to guidelines by V.V. Shkarin et al., 2010; sensitivity to AB - by disc-diffusion method.
  
  
  RESULTS
  Among PSI causative agents resistant to DA the portion of poly-antibiotic resistant strains is higher than among microorganisms sensitive to DA, and among antibiotic resistant bacteria the number of strains resistant to DA is higher than among sensitive to antibiotics. The increase of resistance to DA and AB of P. aeruginosa strains is observed in parallel to the increase of volume of the antibacterial preparations used.
  
  
  CONCLUSIONS
  The results obtained give evidence of the possibility of formation of combined (associated) resistance to DA and AB by nosocomial PSI causative agents against the background of increase of their consumption.
authors.forename: V I
authors.initials: VI
authors.lastname: Sergevnin
authors.forename: T V
authors.initials: TV
authors.lastname: Kliukina
authors.forename: N M
authors.initials: NM
authors.lastname: Kliuchareva
authors.forename: E O
authors.initials: EO
authors.lastname: Volkova
authors.forename: L G
authors.initials: LG
authors.lastname: Kudriavtseva
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D004202:Disinfectants / Q000008:administration & dosage*; D024881:Drug Resistance, Bacterial / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D004202:Disinfectants