title: Preparation and evaluation of liver-targeting micelles loaded with oxaliplatin.
abstract: We prepared liver-targeting micelles loaded with oxaliplatin (OXA), using a polymer modified by a liver-targeting ligand, namely, glycyrrhetinic acid-conjugated and stearic acid-grafted chitosan (GA-CS-SA). The particles had a uniform size, which was 138.6 ± 0.72 nm. The encapsulation efficiency was up to 71.7 ± 0.46%. The hepatic distribution of OXA in mice given OXA-GA-CS-SA was significantly superior to that in the controls (P < 0.05), which means that liver-targeted delivery of OXA was achieved. These results reveal that OXA-GA-CS-SA could be a potential and promising candidate for efficiently targeted delivery of OXA.
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Guowen
authors.initials: G
authors.lastname: Yan
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Lisa
authors.initials: L
authors.lastname: Xu
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Haitian
authors.initials: H
authors.lastname: Wei
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.affiliation: a College of Pharmacy, Qingdao University , Qingdao, Shandong , P. R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D065546:Drug Liberation; D006034:Glycyrrhetinic Acid / Q000737:chemistry; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008823:Micelles; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000493:pharmacokinetics; D000077150:Oxaliplatin; D013229:Stearic Acids / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D008823:Micelles; D009944:Organoplatinum Compounds; D013229:Stearic Acids; D000077150:Oxaliplatin; C031183:stearic acid; D048271:Chitosan; D006034:Glycyrrhetinic Acid
keywords: nanoparticle; oxaliplatin; pharmacokinetics; tumor