title: Anatomical criteria of malignancy by computed tomography angiography in patients with anomalous coronary arteries with an interarterial course.
abstract: OBJECTIVE
  We sought to determine the relation between major adverse cardiac events (MACE) and anatomical criteria assessed by coronary computed tomography angiography (CCTA) in patients with an anomalous coronary artery with an interarterial course (ACAIAC).
  
  
  METHODS
  We selected CCTA studies of patients with an ACAIAC from a database of 4,160 examinations and studied anatomical criteria according to the presence of prior MACE, defined as syncope, unstable angina, myocardial infarction and resuscitated sudden cardiac death.
  
  
  RESULTS
  There were 19 patients (18 males) with an ACAIAC during the study period (incidence 0.46 %). Seven patients with prior MACE were younger (26 years vs 59 years, p < 0.001), had a smaller minimal lumen area (3.6 mm(2) vs 9.0 mm(2), p = 0.001), a higher degree of area stenosis (57 % vs 24 %, p = 0.001), a longer interarterial course (14.7 vs 8.6 mm, p = 0.003) and a smaller proximal segment width (1.6 mm vs 2.5 mm, p = 0.02) compared with the 12 patients without prior MACE. All patients with MACE had the following concomitant anatomical characteristics: minimum lumen area ≤4 mm(2), an area stenosis ≥50 % and intra-arterial length >10 mm
  
  
  CONCLUSIONS
  Prior MACE is associated with specific anatomical CCTA characteristics among patients with ACAIAC. CCTA may therefore contribute to distinguish patients at risk of adverse events.
authors.affiliation: Department of Radiology, Cardiovascular Imaging Unit, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Université Paris Descartes, 20 rue Leblanc, 75015, Paris, France.
authors.forename: Golmehr
authors.initials: G
authors.lastname: Ashrafpoor
authors.forename: Nicolas
authors.initials: N
authors.lastname: Danchin
authors.forename: Lucile
authors.initials: L
authors.lastname: Houyel
authors.forename: Ramzi
authors.initials: R
authors.lastname: Ramadan
authors.forename: Emre
authors.initials: E
authors.lastname: Belli
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Paul
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000209:etiology / Q000473:pathology; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000473:pathology; D003330:Coronary Vessel Anomalies / Q000000981:diagnostic imaging / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods