title: Controlled release of folic acid through liquid-crystalline folate nanoparticles.
abstract: The present study explores folate nanoparticles as nano-carriers for controlled drug delivery. Cross-linked nanoparticles of liquid crystalline folates are composed of ordered stacks. This paper shows that the folate nanoparticles can be made with less than 5% loss in folate ions. In addition, this study shows that folate nanoparticles can disintegrate in a controlled fashion resulting in controlled release of the folate ions. Release can be controlled by the size of nanoparticles, the extent of cross-linking and the choice of cross-linking cation. The effect of different factors like agitation, pH, and temperature on folate release was also studied. Studies were also carried out to show the effect of release medium and role of ions in the release medium on disruption of folate assembly.
authors.affiliation: Advance Materials & Nanoscience Laboratory, Department of Chemical Engineering, Indian Institute of Technology-Delhi, HauzKhas, New Delhi 110016, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Misra
authors.affiliation: Department of Nanotechnology, Amity University, Noida, India.
authors.forename: Henna
authors.initials: H
authors.lastname: Katyal
authors.affiliation: Advance Materials & Nanoscience Laboratory, Department of Chemical Engineering, Indian Institute of Technology-Delhi, HauzKhas, New Delhi 110016, India. Electronic address: sanatm@chemical.iitd.ac.in.
authors.forename: Sanat
authors.initials: S
authors.lastname: Mohanty
mesh_terms: D003692:Delayed-Action Preparations / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005492:Folic Acid
keywords: Chromonics; Control release; Cross-linking; Folates; Nanoparticles