title: Investigation of physical and chemical stability of ointment with herbals.
abstract: The physical and chemical stability of a stock preparation ointment with active ingredients-herbal tinctures of calendula and arnica-for the treatment of hemorrhoids was studied. Evaluations for physical and chemical stability were performed initially and throughout the storage period. Physical stability of the ointment was assessed by means of visual observation in normal room light. Throughout the study period, the physical appearance of the ointment did not change. The chemical stability of the ointment was evaluated by means of a stability-indicating, thin-layer chromatography analytical technique. The shelf-life was found to be one month at 25 degrees C +/- 2 degrees C/60% RH and two months at 5 degrees C +/- 3 degrees C, when protected from light.
authors.forename: Oleksandr A
authors.initials: OA
authors.lastname: Zdoryk
authors.forename: Kateryna O
authors.initials: KO
authors.lastname: Khokhlova
authors.forename: Victoriya A
authors.initials: VA
authors.lastname: Georgiyants
authors.forename: Liliia I
authors.initials: LI
authors.lastname: Vyshnevska
mesh_terms: D018650:Arnica; D020838:Calendula; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004339:Drug Compounding; D004355:Drug Stability; D004356:Drug Storage; D006484:Hemorrhoids / Q000188:drug therapy; D006801:Humans; D006813:Humidity; D008027:Light; D009824:Ointments; D010782:Photolysis; D008517:Phytotherapy; D028321:Plant Preparations / Q000737:chemistry* / Q000528:radiation effects / Q000627:therapeutic use; D010946:Plants, Medicinal; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature; D013997:Time Factors
chemical_list: D009824:Ointments; D028321:Plant Preparations