title: Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring.
abstract: Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in offspring exposed to perinatal TFAs. On the first day of pregnancy rats were divided into four groups: control diet (C), control diet with 0.5% Jussara supplementation (CJ), diet enriched with hydrogenated vegetable fat, rich in TFAs (T), or T diet supplemented with 0.5% Jussara (TJ) during pregnancy and lactation. We showed that Jussara supplementation in maternal diet (CJ and TJ groups) reduced carcass lipid/protein ratios, serum lipids, glucose, IL-6, TNF-α, gene expression of IL-6R, TNF-αR (P < 0.05), TLR-4 (P < 0.01), and increase Lactobacillus spp. (P < 0.05) in the colon of offspring compared to the T group. The IL-10 (P = 0.035) and IL-10/TNF-α ratio (P < 0.01) was higher in the CJ group than in the T group. The 0.5% Jussara supplementation reverses the adverse effects of perinatal TFAs, improving lipid profiles, glucose levels, body composition, and gut microbiota and reducing low-grade inflammation in the colon of 21-day-old offspring, and could contribute to reducing chronic disease development.
authors.affiliation: Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brazil.
authors.forename: Carina
authors.initials: C
authors.lastname: Almeida Morais
authors.affiliation: Departamento de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
authors.affiliation: Departamento de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Juliana Lopez
authors.initials: JL
authors.lastname: de Oliveira
authors.affiliation: Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim 136, Laboratório 311, Vila Mathias, 11015-020 Santos, SP, Brazil.
authors.forename: Márcia
authors.initials: M
authors.lastname: Carvalho Garcia
authors.affiliation: Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim 136, Laboratório 311, Vila Mathias, 11015-020 Santos, SP, Brazil.
authors.forename: Veridiana Vera
authors.initials: VV
authors.lastname: de Rosso
authors.affiliation: Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim 136, Laboratório 311, Vila Mathias, 11015-020 Santos, SP, Brazil.
authors.forename: Laís
authors.initials: L
authors.lastname: Sousa Mendes Amigo
authors.affiliation: Departamento de Fisiologia da Nutrição, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Claudia Maria Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.affiliation: Departamento de Biociências, Instituto de Saúde e Sociedade, Universidade Federal de São Paulo, Rua Silva Jardim 136, Laboratório 311, Vila Mathias, 11015-020 Santos, SP, Brazil.
authors.forename: Luciana Pellegrini
authors.initials: LP
authors.lastname: Pisani
mesh_terms: D015415:Biomarkers / Q000097:blood*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000188:drug therapy*; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007774:Lactation / Q000378:metabolism; D011247:Pregnancy; D044242:Trans Fatty Acids / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D044242:Trans Fatty Acids; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10