title: A big surprise in the little zygote: the curious business of losing methylated cytosines.
abstract: In stem cell biology, the dynamic addition and removal of 5-methylcytosines (5mCs) are necessary for lineage differentiation, nuclear reprogramming, and embryonic development. Recent investigations have sought to understand the mechanisms of how 5mCs are added and in particular how 5mCs are removed from DNA during embryogenesis.
authors.affiliation: Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Sofia
authors.initials: S
authors.lastname: Gkountela
authors.affiliation: Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: clarka@ucla.edu.
authors.forename: Amander T
authors.initials: AT
authors.lastname: Clark
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D019175:DNA Methylation / Q000235:genetics*; D005260:Female; D008297:Male; D008322:Mammals / Q000235:genetics*