title: [Prevalence of decreasing vitamin D reserves in black patients undergoing intermittent hemodialysis in Dakar (Senegal): 37 cases].
abstract: It is now established that vitamin D acts as a steroid hormone via a nuclear receptor to perform its varied functions in mineral metabolism. Very few studies in sub-Saharan Africa, and in Senegal in particular, have focused on the prevalence of low vitamin D reserves in black individuals living in this sunny region. We conducted this study to assess the prevalence of a drop in vitamin D reserves in a population of blacks undergoing intermittent hemodialysis. This descriptive study took place at three hemodialysis centers in Dakar and included 37 patients whose 25-hydroxyvitamin D (25-OH-D) levels had been assayed. The patients' mean age was 51 years, and their sex ratio 1.49. The average concentration of 25-OH-D was 70 nmol/L. Below-normal reserves were found in 23 patients (62.2%), especially among those aged 50-75 years. All patients with low 25-OH-D reserves received vitamin D3 supplementation at a dose of 100,000 IU of cholecalciferol per month. This supplementation normalized 25-OH-D levels in the 10 patients subsequently tested. Given the small sample size, a study with a larger number of patients is needed to reach a conclusion about the exact prevalence of low vitamin D reserves in this population and to investigate possible associated factors.
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Moustapha Cisse
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: E H
authors.initials: EH
authors.lastname: Fary Ka
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Tall Lemrabott
authors.affiliation: Service de médecine préventive, université Cheikh Anta Diop, Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: MBacke Leye
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: M
authors.initials: M
authors.lastname: Faye
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: A
authors.initials: A
authors.lastname: Niang
authors.affiliation: Service de néphrologie, hôpital Aristide Le Dantec, 30 avenue Pasteur, 3001 Dakar, Sénégal.
authors.forename: B
authors.initials: B
authors.lastname: Diouf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044383:Black People; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012675:Senegal; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000175:diagnosis*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Senegal; hemodialysis; vitamin D deficiency