title: In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae.
abstract: The in vitro activities of AZD0914, levofloxacin, azithromycin, and doxycycline against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae were tested. For AZD0914, the MIC90s for C. trachomatis and C. pneumoniae were 0.25 μg/ml (range, 0.06 to 0.5 μg/ml) and 1 μg/ml (range, 0.25 to 1 μg/ml), respectively, and the minimal bactericidal concentrations at which 90% of the isolates were killed (MBC90s) were 0.5 μg/ml for C. trachomatis (range, 0.125 to 1 μg/ml) and 2 μg/ml for C. pneumoniae (range, 0.5 to 2 μg/ml).
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, USA.
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Kohlhoff
authors.affiliation: Infection iMed, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Huband
authors.affiliation: Division of Infectious Diseases, Department of Pediatrics, State University of New York Downstate Medical Center, Brooklyn, New York, USA mhammerschlag@downstate.edu.
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Hammerschlag
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D001463:Barbiturates / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D016993:Chlamydophila pneumoniae / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D027081:DNA Gyrase / Q000378:metabolism*; D004318:Doxycycline / Q000494:pharmacology; D007555:Isoxazoles; D064704:Levofloxacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009025:Morpholines; D023303:Oxazolidinones; D013141:Spiro Compounds / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001463:Barbiturates; D007555:Isoxazoles; D009025:Morpholines; D023303:Oxazolidinones; D013141:Spiro Compounds; D059005:Topoisomerase II Inhibitors; D064704:Levofloxacin; D017963:Azithromycin; D027081:DNA Gyrase; C000599190:zoliflodacin; D004318:Doxycycline