title: The effect of different local anesthesia methods on pain relief in outpatient endometrial biopsy: randomized clinical trial.
abstract: BACKGROUND
  Endometrial biopsy is necessary for diagnosing the reason of abnormal uterine bleeding in perimenopausal women. Currently outpatient endometrial biopsy is used for evaluation of abnormal uterine bleeding which is associated with moderate to severe pain. Using lidocaine is one of the procedures which is used for pain relief while biopsy. This study is aimed at comparing the effect of different local anesthesia procedures on pain relief during endometrial biopsy.
  
  
  METHODS
  In this randomized clinical trial, 160 multiparous 40-55 years old women with AUB, candidates for endometrial biopsy, were randomly assigned into four equal groups, to receive: 1-intrauterine lidocaine; 2-cervical spray lidocaine; 3- intrauterine lidocaine plus cervical spray lidocaine; or 4-intrauterine distilled water. Pain relief was measured at 3 different times: during endometrial biopsy, just after and 15 minutes after biopsy.
  
  
  RESULTS
  Pain intensity was reduced significantly at different times in intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine receivers in compare with the groups which received cervical spray lidocaine and distilled water. The mean of difference pain relief during biopsy and 15 minutes after that was reduced significantly in the group which received intrauterine lidocaine and intrauterine lidocaine with cervical spray lidocaine in comparison with the other two groups.
  
  
  CONCLUSIONS
  Intrauterine lidocaine was effective during endometrial biopsy, and using it with cervical spray lidocaine had no more beneficial effect.
authors.affiliation: Women's reproductive health research center, Tabriz University of Medicine Sciences, Tabriz, Iran.
authors.forename: Elaheh
authors.initials: E
authors.lastname: Olad-Saheb-Madarek
authors.affiliation: Women's reproductive health research center, Tabriz University of Medicine Sciences, Tabriz, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Ghojazaeh
authors.affiliation: Women's reproductive health research center, Tabriz University of Medicine Sciences, Tabriz, Iran.
authors.forename: Fahimeh
authors.initials: F
authors.lastname: Behjati
authors.affiliation: Expert , Publication office, Tabriz University of Medicine Sciences, Tabriz, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Alikhah
keywords: Anesthesia; Biopsy; Lidocaine; Pain; Suction curette