title: [Identification of a novel HLA allele HLA-DRB1*09:01:07].
abstract: OBJECTIVE
  To identify and confirm a novel HLA allele in a Chinese Han individual.
  
  
  METHODS
  HLA typing was performed by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) for HLA-A, -B and -DRB1 in a registered donor of China Marrow Donor Program(CMDP). Sequencing-based typing (SBT) was carried out to further confirm the novel allele of HLA-DRB1.
  
  
  RESULTS
  The SSOP result showed HLA-DRB1*09:03,15GEP, but an unusual pattern that could not be defined indicated potential presence of a novel allele. The SBT result showed the novel sequence has 1nt change from its closest allele DRB1*09:01:02 at nt306 where C to T(codon 73 GCC to GCT) resulting in no amino acid change. 73A was not changed.
  
  
  CONCLUSIONS
  A novel HLA allele, HLA-DRB1*09:01:07, has been identified and named officially by WHO Nomenclature Committee for Factors of the HLA System.
authors.affiliation: Liaoning Blood Center, Key Laboratory of Blood Safety Research of Liaoning, Key Laboratory of Blood Safety Research of Shenyang, Shenyang, Liaoning 110044, P.R.China. ljp_63@163.com.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Kunlian
authors.initials: K
authors.lastname: Zhang
authors.forename: Fengqiu
authors.initials: F
authors.lastname: Lin
authors.forename: Jianping
authors.initials: J
authors.lastname: Li
mesh_terms: D001483:Base Sequence; D001782:Blood Donors; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D017422:Sequence Analysis, DNA
chemical_list: D059811:HLA-DRB1 Chains