title: Biopsy sampling and histopathological markers for diagnosis of prostate cancer.
abstract: Prostate cancer is one of the most common malignant tumors and a leading cause of cancer-related morbidity and mortality. Irrespective of the method that allows for risk stratification of prostate cancer suspects, diagnosis relies on tissue sampling through prostate biopsy and subsequent histopathological evaluation. This provides critical information about disease aggressiveness, which is required for adequate patient management. Prostate biopsy methods have significantly evolved over the years, including the definition of indications, sampling schemes and use of imaging techniques (ultrasound and MRI) that allow for more accurate tissue sampling. In response to the challenges emerging from more precise collection of minute prostate tissue samples for analysis, histopathological assessment should include not only the observation of routinely stained sections, but also, and increasingly so, a series of ancillary techniques, especially immunohistochemistry, which increment the accuracy of prostate cancer diagnosis and may provide relevant information to guide patient management.
authors.affiliation: Department of Pathology, Portuguese Oncology Institute, Rua Dr. António Bernardino Almeida, 4200-072 - Porto, Portugal.
authors.forename: Ângelo
authors.initials: Â
authors.lastname: Rodrigues
authors.forename: Rui
authors.initials: R
authors.lastname: Freitas
authors.forename: Pedro
authors.initials: P
authors.lastname: Nogueira-Silva
authors.forename: Carmen
authors.initials: C
authors.lastname: Jerónimo
authors.forename: Rui
authors.initials: R
authors.lastname: Henrique
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism* / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D016032:Randomized Controlled Trials as Topic / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor
keywords: biomarkers; histopathology; immunohistochemistry; prostate biopsy; prostate cancer; ultrasound