title: Circulating betatrophin levels are increased in patients with type 2 diabetes and associated with insulin resistance.
abstract: BACKGROUND
  Betatrophin has recently attracted increasing interests as a potential β-cell regenerative therapy in diabetes. However, differences in betatrophin profiles in patients with type 2 diabetes mellitus (T2DM) remain unclear.
  
  
  OBJECTIVE
  The objective of the study was to examine circulating betatrophin levels in subjects with different glucose tolerance status and its correlation with insulin resistance.
  
  
  METHODS
  Serum betatrophin levels were measured using an ELISA in age-, sex-, body mass index-, and blood lipid-matched subjects with normal glucose tolerance (n = 137), isolated impaired fasting glucose (n = 69), isolated impaired glucose tolerance (n = 120), and newly diagnosed T2DM (n = 112) from the Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal study.
  
  
  RESULTS
  Serum betatrophin levels were elevated in patients with T2DM compared with subjects with normal glucose tolerance, isolated impaired fasting glucose, or isolated impaired glucose tolerance (798.6 ± 42.5 vs 692.7 ± 29.0, P < .05, vs 682.7 ± 43.0, P < .05, vs 646.8 ± 34.3 pg/mL, P < .01). Betatrophin levels positively correlated with the index of homeostasis model assessment of insulin resistance (partial r = 0.11); inversely correlated with quantitative insulin sensitivity check index (partial r = -0.11), the Gutt insulin sensitivity index (partial r = -0.12), and the Matsuda insulin sensitivity index (partial r = -0.11) after controlling for age, sex, body mass index, and blood lipid in all participants (all values of P < .05).
  
  
  CONCLUSIONS
  Circulating betatrophin levels are increased in patients with T2DM and associated with indexes of insulin resistance.
authors.affiliation: Division of Endocrinology (X.C., P.L., W.H., J.Z., Y.Y., Z.L., J.X., S.S., T.D., X.S., X.Z., S.H., G.Y., M.Z., X.Y.), Department of Internal Medicine, Division of Cardiology (Le.L., D.W.), Department of Internal Medicine, Department of Ophthalmology (H.Z.), Tongji Hospital, and Department of Nutrition and Food Hygiene (Li.L.), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, People's Republic of China.
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Puhan
authors.initials: P
authors.lastname: Lu
authors.forename: Wentao
authors.initials: W
authors.lastname: He
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhelong
authors.initials: Z
authors.lastname: Liu
authors.forename: Junhui
authors.initials: J
authors.lastname: Xie
authors.forename: Shiying
authors.initials: S
authors.lastname: Shao
authors.forename: Tingting
authors.initials: T
authors.lastname: Du
authors.forename: Xianghui
authors.initials: X
authors.lastname: Su
authors.forename: Xinrong
authors.initials: X
authors.lastname: Zhou
authors.forename: Shuhong
authors.initials: S
authors.lastname: Hu
authors.forename: Gang
authors.initials: G
authors.lastname: Yuan
authors.forename: Muxun
authors.initials: M
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Liegang
authors.initials: L
authors.lastname: Liu
authors.forename: Daowen
authors.initials: D
authors.lastname: Wang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D036361:Peptide Hormones / Q000097:blood*; D011236:Prediabetic State / Q000097:blood*
chemical_list: C576683:ANGPTL8 protein, human; D000091306:Angiopoietin-Like Protein 8; D000075802:Angiopoietin-like Proteins; D036361:Peptide Hormones