title: [Radiation-induces increased tumor cell aggressiveness of tumors of the glioblastomas?].
abstract: Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines. We realized a review of the literature of photon-enhanced effect on invasion and migration of glioblastoma cells by radiotherapy.
authors.affiliation: Centre Antoine Lacassagne, Département de radiothérapie, 33, avenue de Valombrose, 06189 Nice cedex, France.
authors.forename: Alexander T
authors.initials: AT
authors.lastname: Falk
authors.affiliation: Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France, Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
authors.forename: Coralie
authors.initials: C
authors.lastname: Moncharmont
authors.affiliation: Inserm U908, Growth factor signalling in breast cancer, functional proteomics, Lille 1 University, IFR-147, 59000 Villeneuve-d'Ascq, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Guilbert
authors.affiliation: Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Guy
authors.affiliation: Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
authors.forename: Gersende
authors.initials: G
authors.lastname: Alphonse
authors.affiliation: Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Jane-Chloé
authors.initials: JC
authors.lastname: Trone
authors.affiliation: Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Rivoirard
authors.affiliation: Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gilormini
authors.affiliation: Inserm U908, Growth factor signalling in breast cancer, functional proteomics, Lille 1 University, IFR-147, 59000 Villeneuve-d'Ascq, France.
authors.forename: Robert-Alain
authors.initials: RA
authors.lastname: Toillon
authors.affiliation: Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Rodriguez-Lafrasse
authors.affiliation: Institut de Cancérologie Lucien Neuwirth, Département de radiothérapie, 108 bis, avenue Albert-Raimond, BP60008, 42271 Saint-Priest-en-Jarez cedex, France, Faculté de Médecine Lyon Sud, EMR3738, Laboratoire de Radiobiologie Cellulaire et Moléculaire, 69921 Oullins, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Magné
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D045744:Cell Line, Tumor / Q000528:radiation effects; D002465:Cell Movement / Q000528:radiation effects; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism; D005909:Glioblastoma / Q000473:pathology / Q000532:radiotherapy*; D063193:Heavy Ion Radiotherapy; D006801:Humans; D016023:Integrins / Q000378:metabolism; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D017785:Photons / Q000009:adverse effects* / Q000627:therapeutic use; D055293:Receptors, Urokinase Plasminogen Activator / Q000378:metabolism; D015398:Signal Transduction / Q000528:radiation effects
chemical_list: D016023:Integrins; D055293:Receptors, Urokinase Plasminogen Activator; D051417:Focal Adhesion Kinase 1
keywords: glioblastoma; hadrontherapy; invasion; migration; photons; radiotherapy