title: Endometrial thickness affects the outcome of in vitro fertilization and embryo transfer in normal responders after GnRH antagonist administration.
abstract: BACKGROUND
  The goal of this study was to assess the association between endometrial thickness on the chorionic gonadotropin (hCG) day and in vitro fertilization and embryo transfer (IVF-ET) outcome in normal responders after GnRH antagonist administration.
  
  
  METHODS
  A retrospective cohort study was performed in normal responders with GnRH antagonist administration from January 2011-December 2013. Patients were divided into four groups according to endometrial thickness, as follows: <7 mm (group 1), > = 7- < 8 mm (group 2), > = 8- < 14 mm (group 3), and > =14 mm (group 4).
  
  
  RESULTS
  A total of 2106 embryo transfer cycles were analyzed. The pregnancy rate (PR) was 44.87%.The clinical pregnancy rate, ongoing pregnancy rate and the implantation rate (17.28%, 13.79%, 10.17%, respectively) were significantly lower in group 1 compared to the other three groups (p < 0.05). The miscarriage rate was higher in patients with endometrial thickness less than 7 mm. The clinical pregnancy rate, ongoing pregnancy rate and implantation rate were highest in patients with endometrial thickness higher than 14 mm, but showed no difference in patients with those of endometrial thickness between 8-14 mm.
  
  
  CONCLUSIONS
  There is a correlation between endometrial thickness measured on hCG day and clinical outcome in normal responders with GnRH antagonist administration. The pregnancy rate was lower in patients with endometrial thickness less than 7 mm compared with patients with endometrial thickness more than 7 mm.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Gao
authors.forename: Xiang
authors.initials: X
authors.lastname: Lu
authors.forename: Ji
authors.initials: J
authors.lastname: Xi
authors.forename: Shan
authors.initials: S
authors.lastname: Jiang
authors.forename: Yin
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Reproductive Medicine, Department of Obstetrics and Gynecology, Shanghai Jiaotong University Affiliated First People's Hospital, No, 650, New Songjiang Road, Shanghai 201620, China. xixiaowei1966@126.com.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Xi
mesh_terms: D000022:Abortion, Spontaneous / Q000139:chemically induced / Q000517:prevention & control; D000328:Adult; D002681:China / Q000453:epidemiology; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D015331:Cohort Studies; D004624:Embryo Transfer; D004717:Endometrium / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000494:pharmacology*; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006801:Humans; D007247:Infertility, Female / Q000473:pathology / Q000628:therapy*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011255:Pregnancy Maintenance / Q000187:drug effects; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D014463:Ultrasonography
chemical_list: D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix