title: PRDM1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour.
abstract: OBJECTIVE
  To determine the role of PRDM1, a key molecule for modulating the immune cells, in Warthin tumour (WT) pathogenesis.
  
  
  METHODS
  Forty paraffin-embedded parotid tissues of patients (mean age: 62.08 ± 11.90) with WT were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The PRDM1 expression was investigated in a cohort of WT by immunohistochemistry.
  
  
  RESULTS
  PRDM1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, PRDM1 expression rates between WT glandular epithelial cells (40/40 cases) and the tumour-adjacent tissues (0/9 cases), and WT germinal centres (0/34 cases) and tonsil tissues (10/10 cases) were significantly different (P < 0.001), respectively.
  
  
  CONCLUSIONS
  The PRDM1 expression appeared to play an essential role in WT pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.
authors.affiliation: Department of Plastic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Fan
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: G
authors.initials: G
authors.lastname: Huang
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Xun
mesh_terms: D000235:Adenolymphoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D018858:Germinal Center / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008221:Lymphoid Tissue / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000473:pathology; D010307:Parotid Neoplasms / Q000378:metabolism*; D000074462:Positive Regulatory Domain I-Binding Factor 1; D012097:Repressor Proteins / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D012097:Repressor Proteins; C087042:PRDM1 protein, human; D000074462:Positive Regulatory Domain I-Binding Factor 1
keywords: PRDM1; Warthin tumour; ectopic lymphoid tissues