title: Tum variants: immunogenic variants obtained by mutagen treatment of tumor cells.
abstract: Mutagen treatment of mouse tumor cells produces at high frequency stable tumor cell variants that are rejected by syngeneic mice. As Thierry Boon discusses here, these 'tum-' variants express new surface antigens that can be recognized by cytolytic T lymphocytes. Tum- variants derived from spontaneous mouse tumors for which no immunogenicity had hitherto been demonstrated induce an immune protection against the parental tumor. Finally, he poses some interesting questions for future investigations.
authors.affiliation: Ludwig Institute for Cancer Research, 74 avenue Hippocrate, UCL 74.59, B-1200 Brussels, Belgium; Cellular Genetics Unit, Catholic University of Louvain, Brussels, Belgium.
authors.forename: T
authors.initials: T
authors.lastname: Boon