title: MicroRNAs in adrenal tumors: relevance for pathogenesis, diagnosis, and therapy.
abstract: Several lines of evidence support the relevance of microRNAs in both adrenocortical and adrenomedullary (pheochromocytomas) tumors. Significantly differentially expressed microRNAs have been described among benign and malignant adrenocortical tumors and different forms of pheochromocytomas that might affect different pathogenic pathways. MicroRNAs can be exploited as markers of malignancy or disease recurrence. Besides tissue microRNAs, novel data show that microRNAs are released in body fluids, and blood-borne microRNAs can be envisaged as minimally invasive markers of malignancy or prognosis. MicroRNAs might even serve as treatment targets that could expand the rather-limited therapeutic repertoire in the field of adrenal tumors. In this review, we present a critical synopsis of the recent observations made in the field of adrenal tumor-associated microRNAs regarding their pathogenic, diagnostic, and potential therapeutic relevance.
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary. igaz.peter@med.semmelweis-univ.hu.
authors.forename: Peter
authors.initials: P
authors.lastname: Igaz
authors.affiliation: Department of Gastroenterology, Szent Imre Teaching Hospital, Tétényi str. 12-16, 1115, Budapest, Hungary.
authors.forename: Ivan
authors.initials: I
authors.lastname: Igaz
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Nagy
authors.affiliation: Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Nyírő
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.
authors.forename: Peter M
authors.initials: PM
authors.lastname: Szabó
authors.affiliation: Department of Genetics Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Nagyvárad sq. 4, 1089, Budapest, Hungary.
authors.forename: András
authors.initials: A
authors.lastname: Falus
authors.affiliation: Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.|"Lendület-2013" Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Patócs
authors.affiliation: 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.|Molecular Medicine Research Group, Hungarian Academy of Sciences and Semmelweis University, Szentkirályi str. 46, 1088, Budapest, Hungary.
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000503:physiopathology*; D016503:Drug Delivery Systems / Q000379:methods; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics* / Q000378:metabolism*; D008954:Models, Biological; D010673:Pheochromocytoma / Q000235:genetics / Q000503:physiopathology*
chemical_list: D005819:Genetic Markers; D035683:MicroRNAs