title: Choroidal neovascularization associated with extensive macular atrophy with pseudodrusen-like appearance.
abstract: OBJECTIVE
  Extensive macular atrophy with pseudodrusen-like appearance (EMAP) is a recently described entity. We describe the first observations of choroidal neovascularization (CNV) associated with EMAP in 3 patients.
  
  
  METHODS
  Nineteen consecutive patients with EMAP were retrospectively investigated for the presence of CNV and treatment outcomes. Each patient underwent a complete ophthalmologic examination including color fundus photograpy, fluorescein angiography (FA), indocyanine green angiography (ICG) and spectral-domain optical coherence tomography (SD-OCT).
  
  
  RESULTS
  Retrospective analysis revealed choroidal neovascularization in 3 patients (4 eyes) out of 19 patients with EMAP. In these patients, laser photocoagulation or intravitreal injections of ranibizumab led to resolution of retinal exudation with limited functional improvement.
  
  
  CONCLUSIONS
  CNV is a possible complication of EMAP, a recently reported form of macular atrophy resembling geographic atrophy. Laser photocoagulation and anti-VEGF treatment appear to be two valuable therapeutic options.
authors.affiliation: Department of Ophthalmology, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France; Université Paris-Est, 61, avenue du Général-de-Gaulle, 94010 Créteil, France.
authors.forename: C
authors.initials: C
authors.lastname: Kamami-Levy
authors.affiliation: Department of Ophthalmology, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France; Université Paris-Est, 61, avenue du Général-de-Gaulle, 94010 Créteil, France. Electronic address: giuseppe.querques@hotmail.it.
authors.forename: G
authors.initials: G
authors.lastname: Querques
authors.affiliation: Department of Ophthalmology, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France; Université Paris-Est, 61, avenue du Général-de-Gaulle, 94010 Créteil, France.
authors.forename: O
authors.initials: O
authors.lastname: Rostaqui
authors.affiliation: Department of Ophthalmology, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France; Université Paris-Est, 61, avenue du Général-de-Gaulle, 94010 Créteil, France.
authors.forename: R
authors.initials: R
authors.lastname: Blanco-Garavito
authors.affiliation: Department of Ophthalmology, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France; Université Paris-Est, 61, avenue du Général-de-Gaulle, 94010 Créteil, France.
authors.forename: E-H
authors.initials: EH
authors.lastname: Souied
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D020256:Choroidal Neovascularization / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D057092:Geographic Atrophy / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D058449:Intravitreal Injections; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D000069579:Ranibizumab; D015593:Retinal Drusen / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D020533:Angiogenesis Inhibitors; D061067:Antibodies, Monoclonal, Humanized; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000069579:Ranibizumab
keywords: Atrophie géographique; Choroidal neovascularization; Drusen; Dystrophie maculaire; Geographic atrophy; Macular dystrophy; Néovascularisation choroïdienne; Optical coherence tomography; Pseudodrusen; Tomographie par cohérence optique