title: Compositional features are potentially involved in the regulation of gene expression of tumor suppressor genes in human tissues.
abstract: Different mechanisms regulate the expression level of tissue specific genes in human. Here we report some compositional features such as codon usage bias, amino acid usage bias, codon frequency, and base composition which may be potentially related to mRNA amount of tissue specific tumor suppressor genes. Our findings support the possibility that structural elements in gene and protein may play an important role in the regulation of tumor suppressor genes, development, and tumorigenesis. The data presented here can open broad vistas in the understanding and treatment of a variety of human malignancies.
authors.affiliation: Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. Electronic address: Mohamad.hajari@gmail.com.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Hajjari
authors.affiliation: Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Khoshnevisan
authors.affiliation: Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Behmanesh
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D001482:Base Composition; D003062:Codon; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D006801:Humans
chemical_list: D000596:Amino Acids; D003062:Codon
keywords: Codon usage; Expression level; In silico analysis; Tumor suppressor gene