title: Reversibly controlling preferential protein adsorption on bone implants by using an applied weak potential as a switch.
abstract: A facile method is needed to control the protein adsorption onto biomaterials, such as, bone implants. Herein we doped taurocholic acid (TCA), an amphiphilic biomolecule, into an array of 1D nano-architectured polypyrrole (NAPPy) on the implants. Doping TCA enabled the implant surface to show reversible wettability between 152° (superhydrophobic, switch-on state) and 55° (hydrophilic, switch-off state) in response to periodically switching two weak electrical potentials (+0.50 and -0.80 V as a switch-on and switch-off potential, respectively). The potential-switchable reversible wettability, arising from the potential-tunable orientation of the hydrophobic and hydrophilic face of TCA, led to potential-switchable preferential adsorption of proteins as well as cell adhesion and spreading. This potential-switchable strategy may open up a new avenue to control the biological activities on the implant surface.
authors.affiliation: School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 (China).
authors.forename: Jingwen
authors.initials: J
authors.lastname: Liao
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhu
authors.forename: Zhengnan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Junqi
authors.initials: J
authors.lastname: Chen
authors.forename: Guoxin
authors.initials: G
authors.lastname: Tan
authors.forename: Chengyun
authors.initials: C
authors.lastname: Ning
authors.forename: Chuanbin
authors.initials: C
authors.lastname: Mao
mesh_terms: D000327:Adsorption / Q000502:physiology*; D001842:Bone and Bones / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry*; D019736:Prostheses and Implants; D011506:Proteins; D011758:Pyrroles / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011108:Polymers; D011506:Proteins; D011758:Pyrroles; C067635:polypyrrole
keywords: bone implants; conducting polymers; polypyrroles; protein adsorption; wettability