title: Epidermal growth factor receptor (EGFR) expression in patients with laryngeal squamous cell carcinoma.
abstract: To assess the epidermal growth factor receptor (EGFR) correlation with histopathologic and clinical characteristics of laryngeal squamous cell carcinoma (SCC) and the impact of EGFR overexpression on patient survival. This retrospective study included 185 SCC patients treated at Clinical Department of ENT, Head and Neck Surgery, Split University Hospital Center between January 1, 2000 and December 31, 2009. A statistically significant correlation (p < 0.001) was recorded between the level of EGFR expression and SCC histopathologic grade, stage, metastasizing potential, relapsing potential, and patient survival. Kaplan-Meier survival curve yielded a statistically significant difference (χ(2) = 75.05; p < 0.001) among the four patient groups with different levels of EGFR expression. The higher the level of EGFR expression, the poorer is the patient prognosis and survival. In our study, expression of EGFR as a biomarker showed a potential predictive value in laryngeal SCC.
authors.affiliation: ENT Department, University of Split School of Medicine, University Hospital Centre Split, Split, Croatia, drmkontic@gmail.com.
authors.forename: Mirko
authors.initials: M
authors.lastname: Kontić
authors.forename: Jovica
authors.initials: J
authors.lastname: Milovanović
authors.forename: Zaviša
authors.initials: Z
authors.lastname: Čolović
authors.forename: Nikola Kolja
authors.initials: NK
authors.lastname: Poljak
authors.forename: Željko
authors.initials: Ž
authors.lastname: Šundov
authors.forename: Ante
authors.initials: A
authors.lastname: Sučić
authors.forename: Valdi
authors.initials: V
authors.lastname: Pešutić-Pisac
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D055771:Serbia / Q000453:epidemiology
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors