title: Magneto-fluorescent core-shell supernanoparticles.
abstract: Magneto-fluorescent particles have been recognized as an emerging class of materials that exhibit great potential in advanced applications. However, synthesizing such magneto-fluorescent nanomaterials that simultaneously exhibit uniform and tunable sizes, high magnetic content loading, maximized fluorophore coverage at the surface and a versatile surface functionality has proven challenging. Here we report a simple approach for co-assembling magnetic nanoparticles with fluorescent quantum dots to form colloidal magneto-fluorescent supernanoparticles. Importantly, these supernanoparticles exhibit a superstructure consisting of a close-packed magnetic nanoparticle 'core', which is fully surrounded by a 'shell' of fluorescent quantum dots. A thin layer of silica coating provides high colloidal stability and biocompatibility, and a versatile surface functionality. We demonstrate that after surface pegylation, these silica-coated magneto-fluorescent supernanoparticles can be magnetically manipulated inside living cells while being optically tracked. Moreover, our silica-coated magneto-fluorescent supernanoparticles can also serve as an in vivo multi-photon and magnetic resonance dual-modal imaging probe.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Ou
authors.initials: O
authors.lastname: Chen
authors.affiliation: Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.
authors.forename: Lars
authors.initials: L
authors.lastname: Riedemann
authors.affiliation: Laboratoire Physico-Chimie Curie, Institut Curie, CNRS UMR168, 75248 Paris, France.
authors.forename: Fred
authors.initials: F
authors.lastname: Etoc
authors.affiliation: 1] Heinrich-Pette-Institute, Martinistrasse 52, 20251 Hamburg, Germany [2] Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, 20359 Hamburg, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Herrmann
authors.affiliation: Laboratoire Physico-Chimie Curie, Institut Curie, CNRS UMR168, 75248 Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Coppey
authors.affiliation: Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Mariya
authors.initials: M
authors.lastname: Barch
authors.affiliation: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.
authors.forename: Christian T
authors.initials: CT
authors.lastname: Farrar
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Oliver T
authors.initials: OT
authors.lastname: Bruns
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: He
authors.initials: H
authors.lastname: Wei
authors.affiliation: Vascular Biology Program, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
authors.forename: Peng
authors.initials: P
authors.lastname: Guo
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Russ
authors.initials: R
authors.lastname: Jensen
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Harris
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Cordero
authors.affiliation: Cornell High Energy Synchrotron Source (CHESS), Wilson Laboratory, Cornell University, Ithaca, New York 14853, USA.
authors.forename: Zhongwu
authors.initials: Z
authors.lastname: Wang
authors.affiliation: 1] Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [2] Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Department of Nuclear Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Alan
authors.initials: A
authors.lastname: Jasanoff
authors.affiliation: Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.
authors.forename: Dai
authors.initials: D
authors.lastname: Fukumura
authors.affiliation: Heinrich-Pette-Institute, Martinistrasse 52, 20251 Hamburg, Germany.
authors.forename: Rudolph
authors.initials: R
authors.lastname: Reimer
authors.affiliation: Laboratoire Physico-Chimie Curie, Institut Curie, CNRS UMR168, 75248 Paris, France.
authors.forename: Maxime
authors.initials: M
authors.lastname: Dahan
authors.affiliation: Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, Massachusetts 02114, USA.
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Jain
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Moungi G
authors.initials: MG
authors.lastname: Bawendi
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide