title: Co-overexpression of Hsp90-β and annexin A1 with a significantly positive correlation contributes to the diagnosis of lung cancer.
abstract: OBJECTIVE
  Hsp90-β and annexin A1 have been demonstrated to be associated with tumorigenesis. However, the effect of Hsp90-β and annexin A1 in lung cancer remains poorly understood. In this research, the correlation of Hsp90-β and annexin A1 in lung cancer patients were analyzed.
  
  
  METHODS
  The expression levels of Hsp90-β and annexin A1 were examined by immunohistochemistry and ELISA.
  
  
  RESULTS
  Lung cancer tissues and serum exhibited higher co-expression of Hsp90-β and annexin A1 than control groups (p < 0.05). Hsp90-β and annexin A1 could discriminate lung cancer from the control groups (sensitivity of Hsp90-β was 80.2% in tissues and 96% in serum; specificity of Hsp90-β was 80% in tissues and 83.33% in serum; sensitivity of annexin A1 was 68.76% in tissues and 95.23% in serum; specificity of annexin A1 was 75% in tissues and 85.7% in serum) and multi-index combined detection had a better diagnostic value.
  
  
  CONCLUSIONS
  The expression levels of Hsp90-β and annexin A1 positively correlated and such co-overexpression of Hsp90-β and annexin A1 contributed to lung cancer diagnosis.
authors.affiliation: Department of Respiratory Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, 157, Xi 5 Road, Xi'an 710004, P.R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Biaoxue
authors.forename: Yang
authors.initials: Y
authors.lastname: Shuanying
authors.forename: Li
authors.initials: L
authors.lastname: Wei
authors.forename: Ming
authors.initials: M
authors.lastname: Zongjuan
authors.forename: Cai
authors.initials: C
authors.lastname: Xiguang
authors.forename: Zhang
authors.initials: Z
authors.lastname: Qiuhong
mesh_terms: D000328:Adult; D000368:Aged; D017305:Annexin A1 / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018841:HSP90 Heat-Shock Proteins / Q000097:blood / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors
chemical_list: D017305:Annexin A1; D014408:Biomarkers, Tumor; D018841:HSP90 Heat-Shock Proteins; C493165:HSP90AB1 protein, human
keywords: Hsp90-β; annexin A1; biomarker; co-expression; lung cancer