title: IgG4-related disease of the aortic valve: a report of two cases and review of the literature.
abstract: IgG4-related disease (IgG4-RD) is a relatively recently described disorder that can affect multiple organ systems, including the cardiovascular system. While most reported cases of cardiovascular involvement are of the aorta, usually the abdominal aorta, rare isolated reports of involvement of the heart proper have been described. Herein, we describe two cases of IgG4-RD involving the aortic valve. Each case was found to be associated with increased levels of IgG4 in the tissue and one case resulted in the subsequent discovery of IgG4-related pancreatitis.
authors.affiliation: Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Maleszewski
authors.affiliation: Department of Laboratory Medicine & Pathology, Mayo Clinic, Scottsdale, AZ, USA.
authors.forename: Henry D
authors.initials: HD
authors.lastname: Tazelaar
authors.affiliation: Department of Pathology, Centegra Hospital-McHenry, McHenry, IL, USA.
authors.forename: Heidi M
authors.initials: HM
authors.lastname: Horcher
authors.affiliation: Department of Surgery, Centegra Hospital-McHenry, McHenry, IL, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hinkamp
authors.affiliation: Department of Surgery, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: John V
authors.initials: JV
authors.lastname: Conte
authors.affiliation: Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: James K
authors.initials: JK
authors.lastname: Porterfield
authors.affiliation: Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA. Electronic address: mhalush1@jhmi.edu.
authors.forename: Marc K
authors.initials: MK
authors.lastname: Halushka
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000473:pathology; D001327:Autoimmune Diseases / Q000473:pathology*; D000082882:Bicuspid Aortic Valve Disease; D005260:Female; D006330:Heart Defects, Congenital / Q000473:pathology*; D006349:Heart Valve Diseases / Q000473:pathology*; D006801:Humans; D007074:Immunoglobulin G; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G
keywords: Endocarditis; Immunologic; Plasma cells