title: Elevated RANTES level is associated with metabolic syndrome and correlated with activated platelets associated markers in healthy younger men.
abstract: The objective of this study was to clarify the relationship of regulated on activation normal T cell expressed and secreted (RANTES) levels with metabolic syndrome (MS) and activated platelets-associated markers. We conducted a cross-sectional study of 210 healthy Japanese male volunteers (mean age 41 years old) who did not take any medications and were free of cardiovascular or cerebrovascular disease. The RANTES is correlated with age, diastolic blood pressure, and fast glucose by multivariate analysis using the cardiovascular risk factors (R (2) = .396, P < .001). The plasma RANTES level is significantly associated with MS after adjusting for age (P = .040). Once plasma interleukin 6, an activator of platelets, and plasma platelet-derived microparticles, a marker for activated platelets, are put into the equation, plasma RANTES level is significantly correlated with the activated platelet-associated markers (R (2) = .396, P < .001). These suggest the possible role of elevated RANTES in the forerunner of atherosclerosis in healthy younger men.
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan Department of Neurosurgery, Kishiwada City Hospital, Osaka, Japan tueba@fukuoka-u.ac.jp.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ueba
authors.affiliation: Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: Shosaku
authors.initials: S
authors.lastname: Nomura
authors.affiliation: Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: Norihito
authors.initials: N
authors.lastname: Inami
authors.affiliation: Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoi
authors.affiliation: Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.
authors.forename: Tooru
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D055252:Cell-Derived Microparticles; D018946:Chemokine CCL5 / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015539:Platelet Activation; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C483024:CCL5 protein, human; D018946:Chemokine CCL5; D015850:Interleukin-6
keywords: RANTES; activated platelets; atherosclerosis; interleukin 6; metabolic syndrome; platelet-derived microparticle