title: Association between CLPTM1L-TERT rs401681 polymorphism and risk of pancreatic cancer: a meta-analysis.
abstract: Telomere biology plays a critical and complex role in the initiation and progression of cancer. Several recent studies have provided evidence that rs401681 polymorphisms in intronic region of cleft lip and palate trans-membrane 1-like (CLPTM1L) gene sequence are associated with pancreatic cancer (PC) development, but a comprehensive synopsis is not available. We performed a meta-analysis of 6 case-control studies that included 8,253 pancreatic cancer cases and 37,646 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, this meta-analysis showed that rs401681 allele T was associated with a significantly increased PC risk (OR = 1.17, 95 % CI = 1.12-1.22, P heterpgeneity = 0.596 and I (2) = 0). Similarly, in the subgroup analysis by ethnicity, a significantly increased risk was found among Asians (OR = 1.15, 95 % CI = 1.07-1.24, P heterpgeneity = 0.297 and I (2) = 8.0 %) and among Caucasian (OR = 1.13, 95 % CI = 1.02-1.26, P heterpgeneity = 0.385 and I (2) = 0). No publication bias was found in the present study. This meta-analysis suggests that T allele of CLPTM1L-telomerase reverse transcriptase rs401681 polymorphism is associated with an increased PC risk, especially among Chinese. Further large and well-designed studies are needed to confirm this association.
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China. liuchengli_kz@163.com.
authors.forename: Cheng-Li
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Department of Stomatology, Air Force General Hospital of PLA, Beijing, 100142, People's Republic of China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Zang
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Kong
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Hepatobiliary Surgery, Air Force General Hospital of PLA, No. 30, Fucheng Road, Haidian District, Beijing, 100142, People's Republic of China.
authors.forename: Hong-Yi
authors.initials: HY
authors.lastname: Zhang
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D019098:Telomerase / Q000235:genetics*
chemical_list: C422445:CLPTM1L protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C509186:TERT protein, human; D019098:Telomerase
keywords: Cleft lip and palate trans-membrane 1-like (CLPTM1L) gene; Pancreatic cancer; Polymorphism; Telomerase reverse transcriptase (TERT)