title: Impact of invasive treatment strategy on health-related quality of life six months after non-ST-elevation acute coronary syndrome.
abstract: BACKGROUND
  Few studies have compared change in the health-related quality of life (HRQL) following treatment of non-ST-elevation acute coronary syndrome (NSTE-ACS) with either percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). This study is to compare changes in HRQL six months after hospital discharge between NSTE-ACS patients who underwent either PCI or CABG.
  
  
  METHODS
  HRQL was assessed using the Seattle angina questionnaire at admission and six months after discharge in 1012 consecutive patients with NSTE-ACS. To assess associations of PCI and CABG with HRQL changes, logistic regression models were constructed treating changes in the score of each dimension of the Seattle angina questionnaire as dependent variables.
  
  
  RESULTS
  Although both the PCI and CABG groups experienced angina relief and other improvements at 6-month follow-up (P < 0.001), the CABG relative to PCI group showed more significant improvements in angina frequency (P = 0.044) and quality of life (P = 0.028). In multivariable logistic analysis, CABG also was an independent predictor for both improvement of angina frequency (OR: 1.62, 95%CI: 1.09-4.63, P = 0.042) and quality of life (OR: 2.04, 95%CI: 1.26-6.92, P = 0.038) relative to PCI.
  
  
  CONCLUSIONS
  In patients with NSTE-ACS, both PCI and CABG provide great improvement in disease-specific health status at six months, with that of CABG being more prominent in terms of angina frequency and quality of life.
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China.
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China.
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China.
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, NO. 2 Anzhen Avenue, Chaoyang District, Beijing 100029, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Chai
keywords: Non-ST elevation acute coronary syndrome; Quality of life; Therapeutic strategy