title: 3',4'-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia.
abstract: OBJECTIVE
  In the present study, effects of 3',4'-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion.
  
  
  METHODS
  The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i.p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively.
  
  
  RESULTS
  In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05).
  
  
  CONCLUSIONS
  All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.
authors.affiliation: a Department of Physiology , Faculty of Medicine, University of Selcuk , Konya , Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oz
authors.affiliation: a Department of Physiology , Faculty of Medicine, University of Selcuk , Konya , Turkey.
authors.forename: Enver Ahmet
authors.initials: EA
authors.lastname: Demir
authors.affiliation: a Department of Physiology , Faculty of Medicine, University of Selcuk , Konya , Turkey.
authors.forename: Merve
authors.initials: M
authors.lastname: Caliskan
authors.affiliation: a Department of Physiology , Faculty of Medicine, University of Selcuk , Konya , Turkey.
authors.forename: Rasim
authors.initials: R
authors.lastname: Mogulkoc
authors.affiliation: a Department of Physiology , Faculty of Medicine, University of Selcuk , Konya , Turkey.
authors.forename: Abdulkerim Kasım
authors.initials: AK
authors.lastname: Baltaci
authors.affiliation: b Department of Pharmacology, Faculty of Meram Medicine , University of Necmettin Erbakan , Konya , Turkey.
authors.forename: K Esra
authors.initials: KE
authors.lastname: Nurullahoglu Atalik
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control; D001522:Behavior, Animal / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000187:drug effects; D044948:Flavonols / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D007859:Learning Disabilities / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D046709:Pattern Recognition, Physiological / Q000187:drug effects; D011897:Random Allocation; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D065853:Spatial Learning / Q000187:drug effects; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D000975:Antioxidants; D044948:Flavonols; D018696:Neuroprotective Agents; C529890:3',4'-dihydroxyflavonol
keywords: Anxiety-like behavior; DiOHF; Learning and memory; Stroke