title: Status of oral anticoagulant treatment in patients with nonvalvular atrial fibrillation in Spain. REACT-AF Study.
abstract: OBJECTIVE
  Oral anticoagulant therapy is complex due to the need for control and the hemorrhagic risk the therapy entails. This study aims to determine the standard clinical practice in the treatment for preventing stroke in patients with nonvalvular atrial fibrillation (NVAF) in Spain.
  
  
  METHODS
  The Real Evidence of Anti Coagulation Treatment in AF is a European, multicenter, multinational, observational, retrospectively monitored cohort of patients with NVAF. This study included patients recruited in Spain with at least one visit during the period of inclusion (May 2010/April 2012). The study evaluated the following: a) persistence of oral anticoagulant treatment (time to discontinuation); b) persistence rate (% of patients in treatment) at 6, 12 and 24 months and at 5 years; c) therapeutic compliance (medication possession ratio); d) the correlation between the treatment followed and that recommended by the European Society of Cardiology; and the incidence of stroke and hemorrhagic events.
  
  
  RESULTS
  The patients treated with oral anticoagulants (n=7,526) had a median time to discontinuation of treatment of 1.99 years and a persistence rate at 5 years of 26% (discontinuation ≥3 months). The compliance (mean MPR) was 0.54±0.36. The incidence of stroke was 0.3/100 person-years, and the incidence of hemorrhagic events was 2.4/100 person-years. Fifty-eight percent of the patients with NVAF (n=12,514) followed the recommendations of the European Society of Cardiology.
  
  
  CONCLUSIONS
  Forty-two percent of the patients with NVAF did not follow the recommendations of the European Society of Cardiology. We detected low persistence and treatment compliance rates for oral anticoagulants.
authors.affiliation: Pharmacoeconomics & Outcomes Research Iberia (PORIB), Pozuelo de Alarcón, Madrid, España. Electronic address: fdeandres@porib.com.
authors.forename: F
authors.initials: F
authors.lastname: de Andrés-Nogales
authors.affiliation: Pharmacoeconomics & Outcomes Research Iberia (PORIB), Pozuelo de Alarcón, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Oyagüez
authors.affiliation: Departamento de Acceso a Mercado, Bristol-Myers Squibb S.A.U., Madrid, España.
authors.forename: L
authors.initials: L
authors.lastname: Betegón-Nicolás
authors.affiliation: Departamento de Acceso a Mercado, Bristol-Myers Squibb S.A.U., Madrid, España.
authors.forename: C
authors.initials: C
authors.lastname: Canal-Fontcuberta
authors.affiliation: Departamento de Investigación de Resultados en Salud y Farmacoeconomía, Pfizer S.L.U., Alcobendas, Madrid, España.
authors.forename: J
authors.initials: J
authors.lastname: Soto-Álvarez
keywords: Adherencia al tratamiento; Anticoagulantes; Anticoagulants; Atrial fibrillation; España; Fibrilación auricular; Ictus; Spain; Stroke; Treatment compliance