title: Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.
abstract: OBJECTIVE
  We evaluated time to clearance of high risk (HR) HPV infection in relation to functional variants in three genes (CYP1A1, GSTT1, and GSTM1).
  
  
  METHODS
  The study group consisted of 450 HR-HPV infected women from the Atypical squamous cells of undetermined significance-low-grade squamous intraepithelial Lesion Triage Study (ALTS) cohort followed up at the clinical center at Birmingham, Alabama. The Cox proportional hazard model with the Wei-Lin-Weisfeld (WLW) approach was used, controlling for relevant covariates.
  
  
  RESULTS
  Women who were polymorphic for CYP1A1 experienced an HR-HPV clearance rate that was 20% (HR=0.80, p=0.04) lower than women without the polymorphism for CYP1A1, adjusting for all other cofactors. The GSTM1 null genotype was associated with higher HR-HPV clearance rate (HR=1.39, p=0.006). The polymorphism in GSTT1 was not significantly associated with time to clearance of HR-HPV.
  
  
  CONCLUSIONS
  Xenobiotic metabolism genes may influence the natural history of HR-HPV infection and its progression to cervical cancer.
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Staci L
authors.initials: SL
authors.lastname: Sudenga
authors.affiliation: Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Sadeep
authors.initials: S
authors.lastname: Shrestha
authors.affiliation: Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Macaluso
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Edward E
authors.initials: EE
authors.lastname: Partridge
authors.affiliation: Biosciences Division, Center for Cancer & Metabolism, SRI International, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Johanning
authors.affiliation: Department of Nutrition Sciences, School of Nutrition, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: piyathic@uab.edu.
authors.forename: Chandrika J
authors.initials: CJ
authors.lastname: Piyathilake
mesh_terms: D000328:Adult; D015331:Cohort Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics* / Q000378:metabolism*; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000201:enzymology* / Q000821:virology*; D002577:Uterine Cervical Diseases / Q000201:enzymology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000201:enzymology / Q000821:virology
chemical_list: D019363:Cytochrome P-450 CYP1A1; D004279:DNA, Viral; D005982:Glutathione Transferase; C569463:CYP1A1 protein, human
keywords: ALTS; CYP1A1; GSTM1; GSTT1; Host genetics