title: Synthesis of some novel chromenopyrimidine derivatives and evaluation of their biological activities.
abstract: Pyrimidine nucleosides are constituents of fundamental structure of the cells. There has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work in the synthesis of pyrimidines containing biological activities, a series of chromenopyrimidine derivatives were synthesized by reaction of an intermediate imine and ammonia derivatives in good to high yields. All synthesized compounds were characterized using IR and NMR ((1)H and (13)C) spectroscopy and elemental analysis data. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922).
authors.affiliation: Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
authors.forename: Akbar
authors.initials: A
authors.lastname: Mobinikhaledi
authors.affiliation: Faculty of Chemistry, Tehran North Branch, Islamic Azad University, Tehran, Iran.
authors.forename: Naser
authors.initials: N
authors.lastname: Foroughifar
authors.affiliation: Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran.
authors.forename: Tahere
authors.initials: T
authors.lastname: Mosleh
authors.affiliation: Department of Biology, Arak University, Arak 38156-8-8349, Iran.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hamta
keywords: Antibacterial; Chromenopyrimidine; Imine; Multicomponent; Pyranopyrimidine