title: Weight loss reduces serum monocyte chemoattractant protein-1 concentrations in association with improvements in renal injury in obese men with metabolic syndrome.
abstract: BACKGROUND
  Monocyte chemoattractant protein-1 (MCP-1) is involved in obesity-related renal injury. The aim of the present study was to examine the effects of weight loss on changes in MCP-1 and markers of renal injury, specifically serum cystatin C (S-CysC) and urinary N-acetyl glucosaminidase (UNAG), in obese people.
  
  
  METHODS
  In this prospective study, 40 obese men with metabolic syndrome (MetS) participated in a 3-month dietary and exercise intervention. Twenty-eight subjects completed the study with a ≥5% weight loss. Circulating MCP-1, S-CysC and UNAG to creatinine ratio (UNCR) were determined before and after the weight loss program.
  
  
  RESULTS
  Obesity-associated components of MetS demonstrated significant improvements after the weight loss program. In addition, at baseline, circulating MCP-1 concentrations were positively correlated with UNCR and S-CysC levels. After weight loss, blood MCP-1 and UNCR levels were significantly decreased, but S-CysC was not affected. Using multiple linear regression analysis, there was a significant relationship between changes in UNCR and MCP-1 after adjusting for other potential confounding factors.
  
  
  CONCLUSIONS
  Weight loss may improve renal tubular injury by ameliorating obesity-related inflammation in obese men with MetS.
authors.forename: Chia-Po
authors.initials: CP
authors.lastname: Fu
authors.forename: Wayne H-H
authors.initials: WH
authors.lastname: Sheu
authors.forename: I-Te
authors.initials: IT
authors.lastname: Lee
authors.forename: Wen-Jane
authors.initials: WJ
authors.lastname: Lee
authors.forename: Jun-Sing
authors.initials: JS
authors.lastname: Wang
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.forename: Wen-Lieng
authors.initials: WL
authors.lastname: Lee
authors.forename: Shih-Yi
authors.initials: SY
authors.lastname: Lin
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000328:Adult; D018932:Chemokine CCL2 / Q000097:blood*; D055316:Cystatin C / Q000097:blood; D004032:Diet; D015444:Exercise; D006801:Humans; D007668:Kidney / Q000293:injuries* / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology* / Q000652:urine; D015431:Weight Loss
chemical_list: C111835:CCL2 protein, human; D018932:Chemokine CCL2; D055316:Cystatin C; C033079:alpha-N-acetyl-D-glucosaminidase; D000118:Acetylglucosaminidase