title: Serum resistin concentrations in children with type 1 diabetes mellitus--negative relation to body fat mass.
abstract: BACKGROUND
  Insulin is one of the major factors regulating adipose tissue function. On the other hand, adipocytes secrete adipocytokines that may influence insulin synthesis and action, and are involved in blood glucose regulation. In type 1 diabetes mellitus (t1DM), beta cells function is replaced with exogenous insulin therapy. This raises a question concerning the impact of t1DM on adipose tissue secretory function. The aim of this study was to evaluate one of the adipocytokines, resistin, serum concentrations in relation to body fat mass in children with t1DM.
  
  
  METHODS
  The study comprised 75 children with t1DM and a control group of 20 healthy coevals. All children had estimated serum resistin concentrations, glycated haemoglobin levels, growth and body weight measurements, and bioelectrical impedance analysis in order to establish body composition.
  
  
  RESULTS
  Resistin serum concentrations were significantly lower in children with t1DM vs. controls (median values: 343 vs. 590 pg/mL; mean values ± SD: 577 ± 561 vs. 861 ± 628 pg/mL; p < 0.001), and they negatively correlated with body fat mass (p = 0.022) and age (p = 0.022) in the t1DM group, but not in the control group. Disease duration, glycated haemoglobin levels and insulin dosage revealed no direct statistical relation to resistin levels.
  
  
  CONCLUSIONS
  Diminished serum resistin concentrations and a negative correlation between resistin levels and body fat mass in children with type 1 diabetes seem to result from broken physiological adipo-insular regulations, independent of disease duration, its metabolic control and insulin supply.
authors.affiliation: kswiton@poczta.onet.pl.
authors.forename: Katarzyna Anna
authors.initials: KA
authors.lastname: Majewska
authors.forename: Dominik
authors.initials: D
authors.lastname: Majewski
authors.forename: Bogda
authors.initials: B
authors.lastname: Skowrońska
authors.forename: Piotr
authors.initials: P
authors.lastname: Fichna
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D012016:Reference Values; D052243:Resistin / Q000097:blood*; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D052243:Resistin