title: I2-mediated oxidative C-N bond formation for metal-free one-pot synthesis of di-, tri-, and tetrasubstituted pyrazoles from α,β-unsaturated aldehydes/ketones and hydrazines.
abstract: An I2-mediated metal-free oxidative C-N bond formation methodology has been established for the regioselective pyrazole synthesis. This practical and eco-friendly one-pot protocol requires no isolation of the less stable intermediates hydrazones and provides a facile access to a variety of di-, tri-, and tetrasubstituted (aryl, alkyl, and/or vinyl) pyrazoles from readily available α,β-unsaturated aldehydes/ketones and hydrazine salts.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , Zhengzhou, Henan Province 450001, China.
authors.forename: Xinting
authors.initials: X
authors.lastname: Zhang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Kang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Niu
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Wenquan
authors.initials: W
authors.lastname: Yu
authors.forename: Junbiao
authors.initials: J
authors.lastname: Chang