title: Disciformycins A and B: 12-membered macrolide glycoside antibiotics from the myxobacterium Pyxidicoccus fallax active against multiresistant staphylococci.
abstract: Two macrolide glycosides with a unique scaffold were isolated from cultures of the myxobacterium Pyxidicoccus fallax. Their structures, including absolute configurations, were elucidated by a combination of NMR, MS, degradation, and molecular modeling techniques. Analysis of the proposed biosynthetic gene cluster led to insights into the biosynthesis of the polyketide and confirmed the structure assignment. The more active compound, disciformycin B, potently inhibits methicillin- and vancomycin-resistant Staphylococcus aureus.
authors.affiliation: Helmholtz Center for Infection Research (HZI), Department Microbial Drugs, Inhoffenstrasse 7, 38124 Braunschweig (Germany); German Center for Infection Research (DZIF), Location: Braunschweig (Germany).
authors.forename: Frank
authors.initials: F
authors.lastname: Surup
authors.forename: Konrad
authors.initials: K
authors.lastname: Viehrig
authors.forename: Kathrin I
authors.initials: KI
authors.lastname: Mohr
authors.forename: Jennifer
authors.initials: J
authors.lastname: Herrmann
authors.forename: Rolf
authors.initials: R
authors.lastname: Jansen
authors.forename: Rolf
authors.initials: R
authors.lastname: Müller
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D009231:Myxococcales / Q000737:chemistry*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides
keywords: antibiotics; biosynthesis; myxobacteria; polyketides; secondary metabolites