title: Decade in review--clinical trials: shifting paradigms in cancer clinical trial design.
authors.affiliation: Department of Health Science Research, Mayo Clinic, 200 First Street SW, Rochester, MN 5590, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Sargent
authors.affiliation: Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 9609 Medical Center Drive, Room 5W112, Bethesda, MD 20892-9735, USA.
authors.forename: Edward L
authors.initials: EL
authors.lastname: Korn
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods* / Q000639:trends*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D018579:Patient Selection; D012107:Research Design / Q000706:statistics & numerical data / Q000639:trends*; D015996:Survival Rate; D016896:Treatment Outcome