title: [Effect of nitric oxide on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in the experiment].
abstract: OBJECTIVE
  To study the effects of nitric oxide (NO) on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in albino rats.
  
  
  METHODS
  The animals were divided into 3 groups. Group included animals with uncomplicated pregnancy; Group 2 was given drinking water containing 0.2% sodium nitrate on day 1 of pregnancy; Group 3 was intramuscularly injected with the NO synthesis inhibitor Nw-nitro-L-arginine methyl ester (L-NAME) in a dose of 10 mg/kg on day 1 of pregnancy. The central portion of hematoxylin- and eosin-stained placentas was morphologically examined. The activity of placental macrophages was assessed by incubating them with autologous erythrocytes.
  
  
  RESULTS
  Pathological examinations of the placentas reveal that when sodium nitrite and L-NAME enter the animal body, structural changes in the placental show that there are maternal and placental circulatory disorders concurrent with dystrophic and destructive processes.
  
  
  CONCLUSIONS
  The activity of placental macrophages in the examined groups is diametrically opposite.
authors.forename: A S
authors.initials: AS
authors.lastname: Ivanova
authors.forename: L P
authors.initials: LP
authors.lastname: Peretiatko
authors.forename: V I
authors.initials: VI
authors.lastname: Demidov
authors.forename: S B
authors.initials: SB
authors.lastname: Nazarov
mesh_terms: D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008264:Macrophages / Q000187:drug effects* / Q000473:pathology; D009566:Nitrates / Q000008:administration & dosage; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D010920:Placenta / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D051381:Rats
chemical_list: D009566:Nitrates; C026512:arginine methyl ester; D009569:Nitric Oxide; C031618:sodium nitrate; D001120:Arginine