title: Monitoring neonatal fungal infection with metabolomics.
abstract: The objective of our study was to evaluate the capability of the metabolomics approach to identify the variations of urine metabolites over time related to the neonatal fungal septic condition. The study population included a clinical case of a preterm neonate with invasive fungal infection and 13 healthy preterm controls. This study showed a unique urine metabolic profile of the patient affected by fungal sepsis compared to urine of controls and it was also possible to evaluate the efficacy of therapy in improving patient health.
authors.affiliation: Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Azienda Ospedaliera Universitaria, University of Cagliari , Cagliari , Italy .
authors.forename: Angelica
authors.initials: A
authors.lastname: Dessì
authors.forename: Barbara
authors.initials: B
authors.lastname: Liori
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Caboni
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corsello
authors.forename: Mario
authors.initials: M
authors.lastname: Giuffrè
authors.forename: Antonio
authors.initials: A
authors.lastname: Noto
authors.forename: Francesca
authors.initials: F
authors.lastname: Serraino
authors.forename: Mauro
authors.initials: M
authors.lastname: Stronati
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
authors.forename: Vassilios
authors.initials: V
authors.lastname: Fanos
mesh_terms: D015415:Biomarkers / Q000652:urine*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000652:urine; D007363:Intensive Care Units, Neonatal; D007558:Italy; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D009181:Mycoses / Q000652:urine*; D025341:Principal Component Analysis
chemical_list: D015415:Biomarkers
keywords: Fungal infections; metabolomics; neonate; sepsis