title: An epigenetic "LINK(RNA)" to pathological cardiac hypertrophy.
abstract: Reinduction of fetal gene expression is characteristic of the failing adult heart. Han et al. (2014) demonstrate that a novel cluster of long noncoding RNAs, Myheart, protects the heart from pathological hypertrophy, involving a negative-feedback molecular circuit with the epigenetic Brg1 complex to inhibit fetal-gene reactivation.
authors.affiliation: Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Jianming
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 320 Longwood Avenue, Boston, MA 02115, USA. Electronic address: dwang@enders.tch.harvard.edu.
authors.forename: Da-Zhi
authors.initials: DZ
authors.lastname: Wang
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D018995:Myosin Heavy Chains / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics*
chemical_list: D062085:RNA, Long Noncoding; D018995:Myosin Heavy Chains