title: A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling.
abstract: Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to tubing and catheters and show that it completely repels blood and suppresses biofilm formation. The coating is a covalently tethered, flexible molecular layer of perfluorocarbon, which holds a thin liquid film of medical-grade perfluorocarbon on the surface. This coating prevents fibrin attachment, reduces platelet adhesion and activation, suppresses biofilm formation and is stable under blood flow in vitro. Surface-coated medical-grade tubing and catheters, assembled into arteriovenous shunts and implanted in pigs, remain patent for at least 8 h without anticoagulation. This surface-coating technology could reduce the use of anticoagulants in patients and help to prevent thrombotic occlusion and biofouling of medical devices.
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Daniel C
authors.identifier: 000000030606792X
authors.initials: DC
authors.lastname: Leslie
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Waterhouse
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Julia B
authors.initials: JB
authors.lastname: Berthet
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Valentin
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Watters
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Jain
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Philseok
authors.initials: P
authors.lastname: Kim
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Hatton
authors.affiliation: Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Nedder
authors.affiliation: Animal Research, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Kathryn
authors.initials: K
authors.lastname: Donovan
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Elana H
authors.initials: EH
authors.lastname: Super
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Howell
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Johnson
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Thy L
authors.initials: TL
authors.lastname: Vu
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Dana E
authors.initials: DE
authors.lastname: Bolgen
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Sami
authors.initials: S
authors.lastname: Rifai
authors.affiliation: 1] Harvard Medical School, Boston, Massachusetts, USA. [2] Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Anne R
authors.initials: AR
authors.lastname: Hansen
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Aizenberg
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] Harvard Medical School, Boston, Massachusetts, USA. [3] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Super
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Aizenberg
authors.affiliation: 1] Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA. [2] School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts, USA. [3] Harvard Medical School, Boston, Massachusetts, USA. [4] Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ingber
mesh_terms: D000818:Animals; D018441:Biofilms / Q000187:drug effects; D057219:Biofouling / Q000517:prevention & control*; D057785:Catheters / Q000382:microbiology; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D004864:Equipment and Supplies / Q000382:microbiology; D006801:Humans; D013499:Surface Properties; D013552:Swine; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D020099:Coated Materials, Biocompatible