title: Complement Factor H Y402H and LOC387715 A69S Polymorphisms in Association with Age-Related Macular Degeneration in Iran.
abstract: OBJECTIVE
  To determine the frequency of complement factor H (Y402H) and age related macular degeneration susceptibility gene 2 (A69S) single nucleotide polymorphisms in patients with age-related macular degeneration (AMD) and in matched non-AMD controls in an Iranian population.
  
  
  METHODS
  Seventy patients with AMD and 86 age- and sex-matched controls were recruited and examined. Peripheral blood sample was obtained from all subjects for DNA extraction and direct sequencing of Y402H and A69S genes. Odds ratios (ORs) with 95% confidence intervals (CIs) for the association of Y402H and A69S polymorphisms with AMD were determined.
  
  
  RESULTS
  The frequencies of both homozygous and heterozygous genotypes were significantly higher in cases than controls for both Y402H and A69S polymorphisms. In comparison to the wild genotypes, OR for AMD associated with Y402H and A69S polymorphisms were 1.9 (95% CI, 1.1-3.2) and 2.2 (95%CI, 1.6-3.1), respectively. Joint risk analysis considering both genes revealed a higher risk of AMD when polymorphisms were present for both genes.
  
  
  CONCLUSIONS
  Y402H and A69S polymorphisms were strongly associated with AMD in this Iranian population.
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran ; USC Eye Institute, University of Southern California, Los Angeles, California, USA.
authors.forename: Hossein
authors.initials: H
authors.lastname: Nazari Khanamiri
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Khalil
authors.initials: K
authors.lastname: Ghasemi Falavarjani
authors.affiliation: National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Sanati
authors.affiliation: National Institute for Genetic Engineering and Biotechnology, Tehran, Iran.
authors.forename: Hajar
authors.initials: H
authors.lastname: Aryan
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Irani
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Masih
authors.initials: M
authors.lastname: Hashemi
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Modarres
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Parvaresh
authors.affiliation: Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Aminollah
authors.initials: A
authors.lastname: Nikeghbali
keywords: Age-related Macular Degeneration; Complement Factor Polymorphism; Gene