title: Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis.
abstract: The current study reports the development of bigels using sorbitan monostearate-sesame oil organogel and carbopol 934 hydrogel. The microstructures and physicochemical properties were investigated by microscopy, viscosity measurement, mechanical analysis and differential scanning calorimetry analysis. Fluorescence microscopy confirmed the formation of oil-in-water type of emulsion gel. There was an increase in the strength of the bigels as the proportion of the organogel was increased in the bigels. The developed bigels showed shear-thinning flow behavior. The stress relaxation study suggested viscoelastic nature of the bigels. The developed bigels were biocompatible. Metronidazole, drug of choice for the treatment of bacterial vaginosis, loaded bigels showed diffusion-mediated drug release. The drug loaded gels showed good antimicrobial efficiency against Escherichia coli. In gist, the developed bigels may be used as delivery vehicles for the vaginal delivery of the drugs.
authors.affiliation: Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela-769008, Odisha, India.
authors.forename: Vinay K
authors.initials: VK
authors.lastname: Singh
authors.affiliation: SABIC Polymer Research Center, Department of Chemical Engineering, King Saud University, Riyadh-11421, Saudi Arabia.
authors.forename: Arfat
authors.initials: A
authors.lastname: Anis
authors.affiliation: Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela-769008, Odisha, India.
authors.forename: Indranil
authors.initials: I
authors.lastname: Banerjee
authors.affiliation: Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela-769008, Odisha, India.
authors.forename: Krishna
authors.initials: K
authors.lastname: Pramanik
authors.affiliation: Department of Botany and Biotechnology, Karimganj College, Karimganj-788710, Assam, India.
authors.forename: Mrinal K
authors.initials: MK
authors.lastname: Bhattacharya
authors.affiliation: Department of Biotechnology & Medical Engineering, National Institute of Technology, Rourkela-769008, Odisha, India. Electronic address: pal.kunal@yahoo.com.
authors.forename: Kunal
authors.initials: K
authors.lastname: Pal
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006601:Hexoses / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry; D008795:Metronidazole / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D012715:Sesame Oil / Q000737:chemistry; D016585:Vaginosis, Bacterial / Q000188:drug therapy*
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004655:Emulsions; D006601:Hexoses; D020100:Hydrogels; C006912:carboxypolymethylene; D008795:Metronidazole; D012715:Sesame Oil; C009298:sorbitan monostearate
keywords: Antimicrobial; Bigels; Carbopol 934; Drug delivery; Sesame oil