title: [Colorectal cancer in children: report of three cases].
abstract: Colorectal cancer (CRC) is extremely infrequent in children and adolescents. There is little information about this entity, mainly case reports and review articles. We describe three cases of children with poor-differentiated colorectal carcinoma and advanced disease at onset. The presenting symptoms were abdominal pain and constipation, with a median of latency of symptoms of 4-48 months. None of these patients had operable disease at onset; having a disease progression despite therapy in two cases. This study reaffirms poor prognosis of pediatric CRC, probably due to an aggressive tumoral biology and advanced stage at diagnosis. Therapeutic guidelines are based in adult treatment; therefore, efforts should be made to improve tools in early diagnosis and future therapies for a better survival in childhood.
authors.affiliation: Departamento de Oncología, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Liliana
authors.initials: L
authors.lastname: Vásquez
authors.affiliation: Departamento de Oncología, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Mónica
authors.initials: M
authors.lastname: Oscanoa
authors.affiliation: Departamento de Oncología, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Iván
authors.initials: I
authors.lastname: Maza
authors.affiliation: Departamento de Oncología, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Jenny
authors.initials: J
authors.lastname: Gerónimo
authors.affiliation: Departamento de Oncología, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Fanny
authors.initials: F
authors.lastname: Tarrillo
authors.affiliation: Departamento de Anatomía Patológica, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Alan
authors.initials: A
authors.lastname: Latorre
authors.affiliation: Departamento del Aparato Digestivo, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Oscar
authors.initials: O
authors.lastname: Frisancho
authors.affiliation: Departamento del Aparato Digestivo, Hospital Nacional Edgardo Rebagliati, EsSalud. Lima, Perú.
authors.forename: Juan
authors.initials: J
authors.lastname: Llatas
mesh_terms: D000293:Adolescent; D002648:Child; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male