title: Human Papillomavirus (HPV) - structure, epidemiology and pathogenesis.
abstract: The number of cancers is constantly increasing. An important role in the etiology of many of them is played by the viral factor, by oncogenic viruses, such as the Human Papillomavirus. The article shows current epidemiological situation and describes the structure of the virus and modes of transmission. It also explains the role of HPV infection in cancer with particular emphasis on oropharynx and head and neck cancer. Summarizing, HPV infection plays an important role in carcinogenesis of the oropharynx tumors. The presence of viral genetic material in the tumor may influence prognosis and treatment method choices.
authors.affiliation: Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Lublinie, Poland. Electronic address: kamal1@op.pl.
authors.forename: Kamal
authors.initials: K
authors.lastname: Morshed
authors.affiliation: Zakład Wirusologii Uniwersytetu Medycznego w Lublinie, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Polz-Gruszka
authors.affiliation: Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Lublinie, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Szymański
authors.affiliation: Zakład Wirusologii Uniwersytetu Medycznego w Lublinie, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Polz-Dacewicz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000473:pathology*; D011379:Prognosis; D055815:Young Adult
keywords: Epidemiology; HPV; Oropharynx cancer; Pathogenesis; Tumors; epidemiologia; nowotwory; patogeneza; rak części ustnej gardła