title: Analysis of polymorphisms in RIG-I-like receptor genes in German multiple sclerosis patients.
abstract: Variation in genes encoding retinoid acid-inducible gene I (RIG-I)-like receptors (RLRs) has been implicated in the pathogenesis of autoimmune disorders. We investigated if polymorphisms in the IFIH1, RIG-I, LGP2 and VISA genes influence the risk for multiple sclerosis (MS) in a German case-control cohort comprising 716 patients and 706 controls. Evaluation of 18 single nucleotide polymorphisms (SNPs) in the four genes did not reveal significant single-SNP associations with MS risk, but two VISA polymorphisms were modestly associated with age of onset. Further, we provide initial evidence for combinatorial effects of polymorphic variants in the RIG-I, LGP2 and IFIH1 genes on MS risk.
authors.affiliation: Laboratory of Human Genetics, Institute of Phthisiopneumology, Kishinev, Republic of Moldova; Department of Human Genetics, Ruhr-University, Bochum, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Varzari
authors.affiliation: Department of Human Genetics, Ruhr-University, Bochum, Germany.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Bruch
authors.affiliation: Department of Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: Igor V
authors.initials: IV
authors.lastname: Deyneko
authors.affiliation: Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany.
authors.forename: Andrew
authors.initials: A
authors.lastname: Chan
authors.affiliation: Department of Human Genetics, Ruhr-University, Bochum, Germany; Faculty of Health, University Witten/Herdecke, Witten, Germany.
authors.forename: Joerg T
authors.initials: JT
authors.lastname: Epplen
authors.affiliation: Department of Human Genetics, Ruhr-University, Bochum, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Hoffjan
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005858:Germany; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D020365:RNA Helicases / Q000235:genetics; D011971:Receptors, Immunologic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C505371:MAVS protein, human; D011971:Receptors, Immunologic; C520569:DHX58 protein, human; C452820:RIGI protein, human; C452815:IFIH1 protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1; D020365:RNA Helicases
keywords: Association; Combinatorial effect; Multiple sclerosis; RIG-I-like receptors; RLRs