title: High temperature hyperthermia treatment for canines exhibiting superficial tumors: A report of three cases.
abstract: High temperature hyperthermia (HTH) treatment has previously been demonstrated to suppress tumor growth in a tumor-bearing rat model. In the present study, the effects of HTH therapy for the treatment of spontaneous tumors in canines was evaluated. In case 1, an 18-year-old female Papillon presented with a right forelimb rhabdomyosarcoma. Case 2 was a 13-year-old male English Cocker Spaniel with a right external auditory canal ceruminous adenocarcinoma and case 3 was a 14-year-old male Golden Retriever that exhibited a perianal gland adenocarcinoma, which surrounded the anus. HTH treatment was performed in all three cases for 10 min at 45-65°C with or without the inhalation of isoflurane. In case 1, the tumor disappeared four weeks following HTH treatment. In case 2, the tumor volume had decreased by day 21, and in case 3, HTH was performed three times and the tumor disappeared following the third procedure. HTH is considered to be a simple procedure with no severe side effects. Consequently, this treatment modality is hypothesized to become a useful alternative therapy for superficial tumors in companion animals.
authors.affiliation: Department of Clinical Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan ; Takagi Animal Clinic, Saijo, Ehime 793-0035, Japan.
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Takagi
authors.affiliation: Department of Veterinary Clinical Science, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Azuma
authors.affiliation: Department of Veterinary Clinical Science, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Osaki
authors.affiliation: Department of Veterinary Clinical Science, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan.
authors.forename: Norihiko
authors.initials: N
authors.lastname: Itoh
authors.affiliation: AdMeTech Co., Ltd, Matsuyama 790-0054, Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Nakazumi
authors.affiliation: Department of Clinical Veterinary Science, The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
authors.forename: Yasuho
authors.initials: Y
authors.lastname: Taura
authors.affiliation: Department of Veterinary Clinical Science, School of Veterinary Medicine, Faculty of Agriculture, Tottori University, Tottori 680-8533, Japan.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Okamoto
keywords: canine; high temperature hyperthermia; spontaneous tumors