title: Combination of ibrutinib with ABT-199: synergistic effects on proliferation inhibition and apoptosis in mantle cell lymphoma cells through perturbation of BTK, AKT and BCL2 pathways.
authors.affiliation: Department of Laboratory Medicine, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: Xiaoxian
authors.initials: X
authors.lastname: Zhao
authors.forename: Juraj
authors.initials: J
authors.lastname: Bodo
authors.forename: Danyu
authors.initials: D
authors.lastname: Sun
authors.forename: Lisa
authors.initials: L
authors.lastname: Durkin
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Lin
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: Smith
authors.forename: Eric D
authors.initials: ED
authors.lastname: Hsi
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives; D000077329:Agammaglobulinaemia Tyrosine Kinase; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D010880:Piperidines; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D011720:Pyrazoles / Q000819:agonists / Q000494:pharmacology; D011743:Pyrimidines / Q000819:agonists / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: C000595707:BCL2 protein, human; D010880:Piperidines; D019253:Proto-Oncogene Proteins c-bcl-2; D011720:Pyrazoles; D011743:Pyrimidines; C551803:ibrutinib; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625949:BTK protein, human; D051057:Proto-Oncogene Proteins c-akt; D000225:Adenine
keywords: BCL-2; Bruton tyrosine kinase; apoptosis; mantle cell lymphoma; synergy