title: [DAB2IP expression in bladder transitional cell carcinoma and its correlation with clinical outcome].
abstract: OBJECTIVE
  To investigate the expression of DAB2IP in bladder transitional cell carcinoma (BTCC) and its correlation with clinical characteristics and prognosis of BTCC patients.
  
  
  METHODS
  Immunohistochemical staining was applied to detect DAB2IP protein level in 79 cases of TCCB tissues and 11 cases of normal bladder tissues, and the relationships of the staining results with pathological grade, stage, lymph node metastasis, gender, age and the 3-year survival rate of the patients were analyzed.
  
  
  RESULTS
  The expression of DAB2IP in BTCC tissues was significantly lower than that in normal bladder epithelium, and the expression score and rate of DAB2IP in the high-grade, invasive and metastatic BTCC were significantly lower than those in low-grade, superficial and non-metastatic BTCC (P < 0.05). The 3-year survival rate of the patients with high DAB2IP expression was significantly higher than that of the patients with low DAB2IP expression.
  
  
  CONCLUSIONS
  DAB2IP may be one of the important inhibitory factors during the occurrence and progression of BTCC.
authors.forename: Jian-Ning
authors.initials: JN
authors.lastname: Zhu
authors.forename: Kai-Jie
authors.initials: KJ
authors.lastname: Wu
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Guan
authors.forename: Li-Xia
authors.initials: LX
authors.lastname: Liu
authors.forename: Zhong-Yun
authors.initials: ZY
authors.lastname: Ning
authors.forename: Jian-Cheng
authors.initials: JC
authors.lastname: Zhou
authors.forename: Xin-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Jin-Hai
authors.initials: JH
authors.lastname: Fan
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008207:Lymphatic Metastasis; D011379:Prognosis; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology; D019459:Urothelium / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
chemical_list: C462952:DAB2IP protein, human; D020703:ras GTPase-Activating Proteins