title: Serum HBV surface antigen positivity is associated with low prevalence of metabolic syndrome in Korean adult men.
abstract: BACKGROUND
  Metabolic syndrome has clinical implications for chronic liver disease, but the relationship between chronic hepatitis B and metabolic syndrome remains unclear. The aim of this study was to determine whether hepatitis B surface antigen (HBsAg) positivity is associated with metabolic syndrome.
  
  
  METHODS
  Data were obtained from the Third Korean National Health and Nutrition Examination Survey (KNHANES). Participant sera were tested for HBsAg. Metabolic syndrome was defined according to the modified National Cholesterol Education Program Adult Treatment Panel III guidelines for Koreans.
  
  
  RESULTS
  Of the 5108 participants, 209 (4.1%) tested positive for HBsAg, and 1364 (26.7%) were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome was 23.4% in HBsAg-positive men, 31.5% in HBsAg-negative men, 18.6% in HBsAg-positive women, and 23.7% in HBsAg-negative women. After adjusting for multiple factors, male participants who tested positive for serum HBsAg had an odds ratio of 0.612 (95% confidence interval [CI] 0.375-0.998) for metabolic syndrome and an odds ratio of 0.631 (95% CI 0.404-0.986) for elevated triglycerides. Women who tested positive for serum HBsAg had an odds ratio of 0.343 (95% CI 0.170-0.693) for elevated triglycerides.
  
  
  CONCLUSIONS
  Positive results for serum HBsAg are inversely associated with metabolic syndrome in men and with elevated triglycerides in men and women. This suggests that elevated triglycerides may contribute to the inverse association between HBsAg and metabolic syndrome.
authors.affiliation: Department of Internal Medicine, Myongji Hospital.
authors.forename: Ja Sung
authors.initials: JS
authors.lastname: Choi
authors.forename: Ki Jun
authors.initials: KJ
authors.lastname: Han
authors.forename: Sangheun
authors.initials: S
authors.lastname: Lee
authors.forename: Song Wook
authors.initials: SW
authors.lastname: Chun
authors.forename: Dae Jung
authors.initials: DJ
authors.lastname: Kim
authors.forename: Hyeon Chang
authors.initials: HC
authors.lastname: Kim
authors.forename: Hee Man
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000328:Adult; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D017678:Sex Distribution
chemical_list: D006514:Hepatitis B Surface Antigens