title: Interferon, β-2-microglobulin and immunoselection in the pathway to malignancy A blinkered view from Nag's Head Yard.
abstract: Recent clinical studies suggest that benign tumour cells express MHC class-I antigens while malignant cells with the same tissue origin do not. Interferons induce normal cells to increase the expression of class-I antigens but Arnold Sanderson and Peter Beverley argue here that malignant cells may not respond in this way. As a result, they may lack the antigens that would make them vulnerable to immune mechanisms dependent on T cells which recognize class-I self-MHC antigens.
authors.affiliation: MRC Immunology Team, Interlab, Nag's Head Yard, Medical School, Guy's Hospital, London SE1 9RT, UK.
authors.forename: A R
authors.initials: AR
authors.lastname: Sanderson
authors.affiliation: ICRF Human Tumour Immunology Group, School of Medicine, University College London, Faculty of Clinical Sciences, London WC1E 6JJ, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Beverley