title: Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment.
abstract: The complexity of glioblastoma multiforme (GBM) and its distinct pathophysiology belong to a unique brain microenvironment and its cellular interactions. Despite extensive evidence of a role for microRNAs in GBM cells, little is known about microRNA-dependent communication between different cellular compartments of the microenvironment that may contribute to the tumor phenotype. While the majority of microRNAs are found intracellularly, a significant number of microRNAs have been observed outside of cells, often encapsulated in secreted extracellular vesicles (EVs). The function of these circulating/secreted microRNAs has not been explored in the context of the brain tumor microenvironment. Establishing how microRNAs are involved in the regulation of oncogenic signaling networks between tumor cells and stroma is likely to add a needed additional layer of complexity to the tumor network, consisting of intercellular communication. More importantly, microRNA/EV signaling may provide an additional therapeutic target for this deadly disease.
authors.affiliation: Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
authors.forename: Jakub
authors.initials: J
authors.lastname: Godlewski
authors.affiliation: Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
authors.forename: Anna M
authors.initials: AM
authors.lastname: Krichevsky
authors.affiliation: Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
authors.forename: Mark D
authors.initials: MD
authors.lastname: Johnson
authors.affiliation: Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
authors.forename: E Antonio
authors.initials: EA
authors.lastname: Chiocca
authors.affiliation: Department of Neurosurgery (J.G., M.D.J., E.A.C., A.B.); Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts (A.M.K).
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Bronisz
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000378:metabolism*; D055354:Exosomes / Q000378:metabolism*; D005909:Glioblastoma / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D015398:Signal Transduction; D059016:Tumor Microenvironment
chemical_list: D035683:MicroRNAs
keywords: exosomes; extracellular vesicles; glioblastoma multiforme; microRNA; tumor microenvironment