title: Analysis of genome-wide significant bipolar disorder genes in borderline personality disorder.
abstract: The objective of this study was to investigate the hypothesis that borderline personality disorder (BPD) and bipolar disorder (BD) share genetic variation through analysis of known genetic risk factors for BD in a well-characterized BPD case-control cohort. Genotyping of five genome-wide significant variants identified for BD (in CACNA1C, ANK3, and ODZ4) was performed in 673 BPD cases and 748 controls. A nominally significant association with BPD was found for rs1006737 in CACNA1C (P=0.0498). Sex-specific analysis showed that this signal was present only in women. This is the first report of an association between a BD risk gene and BPD where selection was not based on a priori hypotheses about its function, but on an unbiased hypothesis-free screening of the genome. Genome-wide association data of large samples of BPD are warranted and will eventually identify new risk genes and the overlap between BPD and BD if it exists.
authors.affiliation: Departments of aGenetic Epidemiology in Psychiatry bPsychosomatic Medicine and Psychotherapy cBiostatistics, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim dDepartment of Genomics, Institute of Human Genetics, Life and Brain Center University of Bonn, Bonn eDepartment of Psychiatry and Psychotherapy, University Medical Center, Mainz fLeibniz Institute for Neurobiology, Magdeburg gDepartment of Psychiatry, Campus Mitte hDepartment of Psychiatry, Campus Benjamin Franklin, Charité-Universitätsmedizin, Berlin iDepartment of Psychiatry, University of Halle, Halle, Germany jDepartment of Biomedicine, Division of Medical Genetics, University of Basel, Basel, Switzerland.
authors.forename: Stephanie H
authors.initials: SH
authors.lastname: Witt
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Kleindienst
authors.forename: Josef
authors.initials: J
authors.lastname: Frank
authors.forename: Jens
authors.initials: J
authors.lastname: Treutlein
authors.forename: Thomas
authors.initials: T
authors.lastname: Mühleisen
authors.forename: Franziska
authors.initials: F
authors.lastname: Degenhardt
authors.forename: Martin
authors.initials: M
authors.lastname: Jungkunz
authors.forename: Bertram
authors.initials: B
authors.lastname: Krumm
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: André
authors.initials: A
authors.lastname: Tadic
authors.forename: Norbert
authors.initials: N
authors.lastname: Dahmen
authors.forename: Cornelia E
authors.initials: CE
authors.lastname: Schwarze
authors.forename: Björn
authors.initials: B
authors.lastname: Schott
authors.forename: Lydia
authors.initials: L
authors.lastname: Dietl
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Arian
authors.initials: A
authors.lastname: Mobascher
authors.forename: Klaus
authors.initials: K
authors.lastname: Lieb
authors.forename: Stefan
authors.initials: S
authors.lastname: Roepke
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Christian
authors.initials: C
authors.lastname: Schmahl
authors.forename: Martin
authors.initials: M
authors.lastname: Bohus
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D001883:Borderline Personality Disorder / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans