title: Outcomes and complications of reconstruction using tumor-bearing frozen autografts in patients with metastatic bone tumors.
abstract: BACKGROUND
  Tumor-bearing frozen autografts have been used for reconstruction of bone defects after resection of bone tumors. In the present study, outcomes and complications of reconstruction using frozen autografts were assessed to determine indications for this procedure in patients with metastatic bone lesions.
  
  
  METHODS
  Twenty-two patients were treated with reconstruction using frozen autografts. The surgical technique involved excision of the bone lesion, curettage, freezing in liquid nitrogen, thawing and reconstruction.
  
  
  RESULTS
  Limb function was evaluated in 11 patients; wa found excellent in 10 patients and good in 1 patient. Five-year overall survival and disease-free survival rates were 46.7% and 26.3%, respectively. Five-year fracture-free survival and recurrence-free survival rates were 79.9% and 100%, respectively. Complications were observed in 6 patients and included fractures (4), deep infection (1) and osteoarthritis (1).
  
  
  CONCLUSIONS
  Reconstruction using frozen autografts is a beneficial treatment option in patients with long expected survival or complete cure of the primary cancer.
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Miwa
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takeuchi
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Shirai
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Yamamoto
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Hayashi
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Hideji
authors.initials: H
authors.lastname: Nishida
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kimura
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Igarashi
authors.affiliation: Department of Orthopedic Surgery, Kanazawa University School of Medicine, Kanazawa, Japan tsuchi@med.kanazawa-u.ac.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuchiya
mesh_terms: D000328:Adult; D000368:Aged; D064592:Autografts; D001859:Bone Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D019651:Plastic Surgery Procedures / Q000009:adverse effects; D016896:Treatment Outcome
keywords: Frozen autograft; bone; cancer; metastasis; reconstruction