title: Frontispiece: asymmetric reduction of α-amino ketones with a KBH4 solution catalyzed by Chiral Lewis acids.
abstract: Asymmetric Alkali Metal Borohydride Reduction Alkali metal borohydrides are mild, inexpensive, highly selective, and environmentally friendly reducing agents in organic chemistry. In their Communication on page 13482 ff., X. Feng et al. demonstrate an efficient enantioselective reduction of both secondary and primary α-amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts. The catalytic system features a convenient operation and tolerance to water, without the need for basic additives.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064 (P. R. China), Fax: (+86) 28-8541-8249.
authors.forename: Peng
authors.initials: P
authors.lastname: He
authors.forename: Haifeng
authors.initials: H
authors.lastname: Zheng
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangjin
authors.initials: X
authors.lastname: Lian
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D000586:Amination; D000588:Amines / Q000737:chemistry; D001894:Borohydrides / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001894:Borohydrides; D007659:Ketones; D058116:Lewis Acids; C028371:potassium borohydride
keywords: N,N′-dioxide-metal complex; alcohols; asymmetric synthesis; ketones; reduction