title: Efficacy of autologous bone marrow concentrate for knee osteoarthritis with and without adipose graft.
abstract: BACKGROUND
  We investigated the use of autologous bone marrow concentrate (BMC) with and without an adipose graft, for treatment of knee osteoarthritis (OA).
  
  
  METHODS
  Treatment registry data for patients who underwent BMC procedures with and without an adipose graft were analyzed. Pre- and posttreatment outcomes of interest included the lower extremity functional scale (LEFS), the numerical pain scale (NPS), and a subjective percentage improvement rating. Multivariate analyses were performed to examine the effects of treatment type adjusting for potential confounding factors. The frequency and type of adverse events (AE) were also examined.
  
  
  RESULTS
  840 procedures were performed, 616 without and 224 with adipose graft. The mean LEFS score increased by 7.9 and 9.8 in the two groups (out of 80), respectively, and the mean NPS score decreased from 4 to 2.6 and from 4.3 to 3 in the two groups, respectively. AE rates were 6% and 8.9% in the two groups, respectively. Although pre- and posttreatment improvements were statistically significant, the differences between the groups were not.
  
  
  CONCLUSIONS
  BMC injections for knee OA showed encouraging outcomes and a low rate of AEs. Addition of an adipose graft to the BMC did not provide a detectible benefit over BMC alone.
authors.affiliation: Regenerative Sciences, The Centeno-Schultz Clinic, 403 Summit Boulevard, Suite 201, Broomfield, CO 80021, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Centeno
authors.affiliation: Regenerative Sciences, The Centeno-Schultz Clinic, 403 Summit Boulevard, Suite 201, Broomfield, CO 80021, USA.
authors.forename: John
authors.identifier: 0000-0002-6119-1176
authors.initials: J
authors.lastname: Pitts
authors.affiliation: Regenerative Sciences, The Centeno-Schultz Clinic, 403 Summit Boulevard, Suite 201, Broomfield, CO 80021, USA.
authors.forename: Hasan
authors.initials: H
authors.lastname: Al-Sayegh
authors.affiliation: Forensic Research and Analysis, Oregon Health and Science University, 425 NW 10th Avenue, Suite 306, Portland, OR 97209, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Freeman
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D016026:Bone Marrow Transplantation; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000503:physiopathology / Q000628:therapy*; D012042:Registries; D011795:Surveys and Questionnaires; D014182:Transplantation, Autologous; D016896:Treatment Outcome