title: Inhibition of diacylglycerol acyltransferase by prenylated flavonoids isolated from the stem bark of Maackia amurensis.
abstract: A new prenylated flavanone, erythraddison Z (1), together with eight known flavonoids (2-9), was isolated from the stem bark of Maackia amurensis. Their structures were elucidated on the basis of spectroscopic methods, including 1D and 2D NMR (COSY, HMQC, and HMBC) techniques. All the isolates, with the exception of 3, 6 and 7, strongly inhibited diacylglycerol acyltransferase activity in an in vitro assay with IC50 values ranging from 96.5 ± 0.6 to 135.1 ± 1.4 μM.
authors.affiliation: a College of Pharmacy, Beihua University , Jilin City 132013 , China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Pei-Ge
authors.initials: PG
authors.lastname: Du
authors.forename: Hyun-Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Long
authors.initials: L
authors.lastname: Cui
mesh_terms: D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029901:Maackia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D054876:Prenylation
chemical_list: D004365:Drugs, Chinese Herbal; D044950:Flavanones; C000598664:erythraddison Z; D051048:Diacylglycerol O-Acyltransferase
keywords: DGAT; Leguminosae; Maackia amurensis; prenylated flavanone