title: Antibiotic resistance, virulence factors and genetics of Clostridium sordellii.
abstract: Clostridium sordellii is gram positive bacterial pathogen of humans and animals. While the incidence of human-related C. sordellii infection is low, the mortality rate associated with infection is high. Of particular concern are C. sordellii infections after child-birth or medical abortion, which have an almost 100% mortality rate. Recent genetic and epidemiological work has increased our understanding of how this pathogen has evolved and how it causes disease. This review will summarise studies involving the genetics of C. sordellii, including an antibiotic resistance profile, the genetic determinants of virulence and mutagenesis of C. sordellii.
authors.affiliation: Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: callum.vidor@monash.edu.
authors.forename: Callum
authors.initials: C
authors.lastname: Vidor
authors.affiliation: Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: milena.awad@monash.edu.
authors.forename: Milena
authors.initials: M
authors.lastname: Awad
authors.affiliation: Department of Microbiology, Monash University, Victoria 3800, Australia. Electronic address: dena.lyras@monash.edu.
authors.forename: Dena
authors.initials: D
authors.lastname: Lyras
mesh_terms: D000818:Animals; D003015:Clostridium Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary; D047989:Paraclostridium sordellii / Q000187:drug effects* / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D006801:Humans; D015994:Incidence; D016019:Survival Analysis; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D037521:Virulence Factors
keywords: Antibiotic resistance; Clostridium; Genetics; Mutagenesis; Toxin