title: The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG).
abstract: Recombinant viral vectors provide an effective means for heterologous antigen expression in vivo and thus represent promising platforms for developing novel vaccines against human pathogens from Ebola to tuberculosis. An increasing number of candidate viral vector vaccines are entering human clinical trials. The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to improve our ability to anticipate potential safety issues and meaningfully assess or interpret safety data, thereby facilitating greater public acceptance when licensed.
authors.affiliation: DHAP, NCHHSTP, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. Electronic address: brightoncollaborationv3swg@gmail.com.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Chen
authors.affiliation: DHAP, NCHHSTP, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
authors.forename: Baevin
authors.initials: B
authors.lastname: Carbery
authors.affiliation: DHAP, NCHHSTP, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Mac
authors.affiliation: Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, P.O. Box 100266, Gainesville, FL 32610, USA.
authors.forename: Kenneth I
authors.initials: KI
authors.lastname: Berns
authors.affiliation: DHAP, NCHHSTP, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
authors.forename: Louisa
authors.initials: L
authors.lastname: Chapman
authors.affiliation: Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, P.O. Box 100266, Gainesville, FL 32610, USA.
authors.forename: Richard C
authors.initials: RC
authors.lastname: Condit
authors.affiliation: International AIDS Vaccine Initiative, New York, NY, USA; U.S. Military HIV Research Program (MHRP), Bethesda, MD 20817, USA.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Excler
authors.affiliation: PaxVax, San Diego, CA 92121, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Gurwith
authors.affiliation: DHAP, NCHHSTP, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Hendry
authors.affiliation: Laboratory of Retroviruses, Division of Viral Products, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, MD 20892, USA.
authors.forename: Arifa S
authors.initials: AS
authors.lastname: Khan
authors.affiliation: Division of Infectious Disease, Jordan University Hospital, Amman, Jordan.
authors.forename: Najwa
authors.initials: N
authors.lastname: Khuri-Bulos
authors.affiliation: Paul-Ehrlich-Institut, 63225 Langen, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Klug
authors.affiliation: Independent Adviser (formerly of National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK).
authors.forename: James S
authors.initials: JS
authors.lastname: Robertson
authors.affiliation: Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA.
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Seligman
authors.affiliation: Division of AIDS, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Sheets
authors.affiliation: Institute of Infectious Disease and Molecular Medicine, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.
authors.forename: Anna-Lise
authors.initials: AL
authors.lastname: Williamson
mesh_terms: D002986:Clinical Trials as Topic; D004337:Drug Carriers / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D005822:Genetic Vectors; D006801:Humans; D007391:International Cooperation; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000235:genetics / Q000276:immunology; D014765:Viral Vaccines / Q000009:adverse effects* / Q000235:genetics / Q000276:immunology
chemical_list: D004337:Drug Carriers; D014614:Vaccines, Synthetic; D014765:Viral Vaccines
keywords: Immunization; Safety; Vaccines; Viral Vector