title: Prothrombin complex concentrate (Beriplex P/N)-related renal and cerebral infarctions in a patient with warfarin-associated intracerebral hemorrhage.
abstract: A 45-year-old man receiving warfarin treatment suffered from an intracerebral hemorrhage. Four-factor prothrombin complex concentrate (PCC) was administered to correct coagulopathy. However, bilateral renal infarcts and a cerebral infarct developed on day 5 and 7, respectively after PCC administration. Although the occurrence of PCC-related thromboembolism is low, health care practitioners should closely follow-up the symptoms and signs of thrombosis after PCC administration.
authors.affiliation: Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Shin-Yi
authors.initials: SY
authors.lastname: Lin
authors.affiliation: Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: tangneuro@gmail.com.
authors.forename: Sun-Chun
authors.initials: SC
authors.lastname: Tang
authors.affiliation: Department of Pharmacy, National Taiwan University Hospital, Taipei, Taiwan; Graduate Institute of Clinical Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Li-Jiuan
authors.initials: LJ
authors.lastname: Shen
authors.affiliation: Stroke Center and Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Jiann-Shing
authors.initials: JS
authors.lastname: Jeng
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000188:drug therapy; D002544:Cerebral Infarction / Q000139:chemically induced*; D004338:Drug Combinations; D005164:Factor IX / Q000009:adverse effects* / Q000627:therapeutic use; D005167:Factor VII / Q000009:adverse effects* / Q000627:therapeutic use; D005170:Factor X / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000139:chemically induced*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011516:Prothrombin / Q000009:adverse effects* / Q000627:therapeutic use; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D004338:Drug Combinations; C525441:factor IX, factor VII, factor X, prothrombin drug combination; D014859:Warfarin; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X
keywords: Prothrombin complex concentrate; renal infarct; stroke; thromboembolism; warfarin