title: PATTERN OF CONSANGUINITY AND INBREEDING COEFFICIENT IN SARGODHA DISTRICT, PUNJAB, PAKISTAN.
abstract: Consanguinity is widespread in Pakistan. The majority of studies on consanguinity in Pakistan have been carried out in urban metropolitan areas, and data on rural populations are scarce. The present cross-sectional study was conducted in Sargodha district, upper Punjab, Pakistan where the majority of the population reside in rural areas. A random sample of 1800 married females belonging to six tehsils of Sargodha district was obtained and differentials in consanguinity rates and inbreeding coefficient (F) were investigated. The consanguinity rate was calculated to be 56.72% and the inbreeding coefficient was 0.0348. First cousin unions had the highest representation (49.11% of all marriages), and marriages up to distantly related/Biradari constituted 67.94% of all marriages. Among the six tehsils, consanguinity rates ranged from 50.38% in Bhalwal to 62.88% in Sillanwali. A high rate of consanguinity was observed in subjects speaking the Punjabi language, those with self-arranged/arranged-love marriages and those engaged in professional jobs. With respect to the occupation of husbands the highest consanguinity rate was found among landowners (77.59%; F=0.0539) and businessmen (62.62%; F=0.0377). However, consanguinity did not appear to be associated with rural/urban origin or literacy level. The data showed a wide variation in consanguinity rate and inbreeding coefficient across socio-demographic strata in the Sargodha district population. A comparison of Sargodha with other populations of Punjab also showed regional heterogeneity in the pattern of consanguinity, warranting further studies.
authors.affiliation: Human Genetics Program, Department of Animal Sciences, Faculty of Biological Sciences,Quaid-i-Azam University,Islamabad,Pakistan.
authors.forename: Saira
authors.initials: S
authors.lastname: Hina
authors.affiliation: Human Genetics Program, Department of Animal Sciences, Faculty of Biological Sciences,Quaid-i-Azam University,Islamabad,Pakistan.
authors.forename: Sajid
authors.initials: S
authors.lastname: Malik
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003241:Consanguinity; D003430:Cross-Sectional Studies; D005190:Family / Q000208:ethnology; D005260:Female; D006801:Humans; D007223:Infant; D007226:Infant Mortality / Q000208:ethnology; D008297:Male; D008393:Marriage / Q000706:statistics & numerical data / Q000639:trends*; D008875:Middle Aged; D010154:Pakistan; D012424:Rural Population / Q000706:statistics & numerical data*; D014505:Urban Population; D055815:Young Adult