title: Obesity, metabolic syndrome, and airway disease: a bioenergetic problem?
abstract: Multiple studies have determined that obesity increases asthma risk or severity. Metabolic changes of obesity, such as diabetes or insulin resistance, are associated with asthma and poorer lung function. Insulin resistance is also found to increase asthma risk independent of body mass. Conversely, asthma is associated with abnormal glucose and lipid metabolism, insulin resistance, and obesity. Here we review our current understanding of how dietary and lifestyle factors lead to changes in mitochondrial metabolism and cellular bioenergetics, inducing various components of the cardiometabolic syndrome and airway disease.
authors.affiliation: Molecular Immunogenetics Laboratory and Centre of Excellence for Translational Research in Asthma & Lung Disease, CSIR-Institute of Genomics and Integrative Biology, Mall Road, Delhi 110007, India. Electronic address: a.agrawal@igib.in.
authors.forename: Anurag
authors.initials: A
authors.lastname: Agrawal
authors.affiliation: Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: prakash.ys@mayo.edu.
authors.forename: Y S
authors.initials: YS
authors.lastname: Prakash
mesh_terms: D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism*; D016535:Bronchial Hyperreactivity / Q000188:drug therapy / Q000196:embryology / Q000378:metabolism; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000187:drug effects*; D015444:Exercise; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000188:drug therapy* / Q000196:embryology / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D009943:Organophosphorus Compounds; D014451:Ubiquinone; C429014:mitoquinone; C024989:coenzyme Q10
keywords: Arginine; Asthma; Bioenergetics; Metabolic syndrome; Metformin; Mitochondria; Reactive oxygen species; Statin