title: Granulocyte colony-stimulating factors as prophylaxis against febrile neutropenia.
abstract: Myelosuppression secondary to chemotherapy remains a serious adverse effect of cancer therapy that causes high morbidity and mortality. Several current European and American guidelines recommend consideration of primary prophylaxis with colony-stimulating factors (CSFs) when the risk of febrile neutropenia is higher than 20 %. The main factors associated with a high risk of febrile neutropenia include the chemotherapy regimen, tumor type, and patient-related factors such as old age and/or comorbidities. The purpose of this paper is to summarize the most relevant clinical trials and updated recommendations of the main guidelines on the role of granulocyte colony-stimulating factors (G-CSFs) in febrile neutropenia, examining whether the combination of G-CSF with chemotherapy improves overall survival. Future directions for G-CSF use are also discussed.
authors.affiliation: Pharmacy Service, UGC Intercentro-Interniveles, University Hospital Virgen de Las Nieves, Av de las Fuerzas Armadas, 2, 18014, Granada, Spain, soldelsur@libero.it.
authors.forename: Sol
authors.initials: S
authors.lastname: Cortés de Miguel
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Calleja-Hernández
authors.forename: Salomón
authors.initials: S
authors.lastname: Menjón-Beltrán
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Vallejo-Rodríguez
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000517:prevention & control*; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D009369:Neoplasms / Q000188:drug therapy*; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim