title: The effect of multiwalled carbon nanotubes on hepatotoxicity of Cd2+ in accumulated cadmium-metallothione in mice.
abstract: The effects of oxidized multiwalled carbon nanotubes (oMWCNTs) on the behavior and hepatotoxicity of Cd(2+) in accumulated cadmium-metallothionein mice were investigated. The results indicated that, after exposure of oMWCNTs to normal mice, oMWCNTs could not induce the liver to produce metallothionein (MT). When exposing Cd-MT mouse to different doses of oMWCNTs oMWCNTs could cause Cd(2+) release from the accumulated Cd-MT; subsequently, one part of the free Cd(2+) was eliminated with blood circulation; the other part adsorbed by oMWCNTs would remain in the tissues together with oMWCNTs. The results of the activities changes of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), and blood urea nitrogen (BUN) in plasma showed that the hepatotoxicity of coexposure was lower than that of single exposure, and the hepatotoxicity and accumulation of oMWCNTs in livers depended strongly on the exposure dosage of oMWCNTs. The histology of liver and kidney tissue also confirmed the previous results. Therefore, the author inferred that MT could be connected with oMWCNTs to reduce their hepatotoxicity, but the detailed mechanism needs to be further studied.
authors.affiliation: Radiochemical Laboratory, Lanzhou University, Lanzhou 730000, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Radiochemical Laboratory, Lanzhou University, Lanzhou 730000, China.
authors.forename: Bi
authors.initials: B
authors.lastname: Juanjuan
authors.affiliation: Radiochemical Laboratory, Lanzhou University, Lanzhou 730000, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Longlong
authors.affiliation: Lanzhou Institute of Chemistry Physics, Chinese Academy of Science, Lanzhou 730000, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhan
authors.affiliation: Radiochemical Laboratory, Lanzhou University, Lanzhou 730000, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Peng
authors.affiliation: Radiochemical Laboratory, Lanzhou University, Lanzhou 730000, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Wangsuo
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D001806:Blood Urea Nitrogen; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D051379:Mice; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010084:Oxidation-Reduction; D017550:Spectroscopy, Fourier Transform Infrared; D013059:Spectrum Analysis, Raman
chemical_list: D037742:Nanotubes, Carbon; C004203:cadmium-binding protein; D002104:Cadmium; D008668:Metallothionein; D001663:Bilirubin