title: In vivo imaging of coin-shaped lesions in cytomegalovirus corneal endotheliitis by anterior segment optical coherence tomography.
abstract: OBJECTIVE
  The aim of this study was to investigate in vivo corneal changes of coin-shaped lesions in cytomegalovirus corneal endotheliitis using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  Two eyes of 2 patients (69- and 71-year-old men), with polymerase chain reaction-proven CMV corneal endotheliitis presenting coin-shaped lesions, were included in this study. AS-OCT examination was performed on the initial visit and at follow-up visits by paying special attention to the coin-shaped lesions. Selected AS-OCT images of the cornea were evaluated qualitatively for changes in the shape and degree of light reflection.
  
  
  RESULTS
  In both cases, coin-shaped lesions were observed at the corneal endothelial surface as clusters of fine precipitates using slit-lamp biomicroscopy. Using AS-OCT, high-resolution images of the putative coin-shaped lesions were successfully obtained in both patients as an irregularly thickened highly reflective endothelial cell layer. After anti-CMV treatment, the coin-shaped lesions were resolved as assessed by slit-lamp biomicroscopy and AS-OCT in both patients.
  
  
  CONCLUSIONS
  High-resolution AS-OCT provides novel and detailed visual information of coin-shaped lesions in patients with CMV corneal endotheliitis. Visualization of coin-shaped lesions by AS-OCT may be a useful adjunct to the diagnosis and follow-up of CMV corneal endotheliitis.
authors.affiliation: Department of Ophthalmology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Yokogawa
authors.forename: Akira
authors.initials: A
authors.lastname: Kobayashi
authors.forename: Natsuko
authors.initials: N
authors.lastname: Yamazaki
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Sugiyama
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000821:virology; D003952:Diagnostic Imaging; D004728:Endothelium, Corneal / Q000473:pathology* / Q000821:virology; D015828:Eye Infections, Viral / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D007634:Keratitis / Q000175:diagnosis* / Q000821:virology; D008297:Male; D018613:Microscopy, Confocal; D016133:Polymerase Chain Reaction; D041623:Tomography, Optical Coherence