title: A dual functional AEE fluorogen as a mitochondrial-specific bioprobe and an effective photosensitizer for photodynamic therapy.
abstract: We report a dual functional aggregation-enhanced emission (AEE) molecule, TPE-IQ, which could target and illuminate mitochondria in both live and fixed cells with superb selectivity and high signal-to-noise ratio. More intriguingly, TPE-IQ can serve as a photosensitizer to generate reactive oxygen species (ROS) in the mitochondria region to induce cell apoptosis.
authors.affiliation: HKUST Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park Nanshan, Shenzhen 518057, China. tangbenz@ust.hk.
authors.forename: Engui
authors.initials: E
authors.lastname: Zhao
authors.forename: Haiqin
authors.initials: H
authors.lastname: Deng
authors.forename: Sijie
authors.initials: S
authors.lastname: Chen
authors.forename: Yuning
authors.initials: Y
authors.lastname: Hong
authors.forename: Chris Wai Tung
authors.initials: CW
authors.lastname: Leung
authors.forename: Jacky Wing Yip
authors.initials: JW
authors.lastname: Lam
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
mesh_terms: D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D015374:Biosensing Techniques; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D011806:Quinolinium Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D005456:Fluorescent Dyes; D017319:Photosensitizing Agents; D011806:Quinolinium Compounds; D017382:Reactive Oxygen Species