title: [Comparative evaluation of the influence of calcium channel blockers of derivatives of 1,4-dihydropyridine--amlodipine and dimeodipine--on parameters of carbohydrate metabolism in the blood of rats with doxorubicin-induced cardiomyopathy].
abstract: Presented are experimental data on the influence of calcium antagonists of the third-generation derivatives of 1,4-dihydropyridines--amlodipine (1.5 mg/kg), dimeodipine (1.5 mg/kg)--on parameters of carbohydrate metabolism in rat blood model doxorubicin-induced cardiomyopathy. The possibility for correcting carbohydrate metabolic disorders in the blood with the above drugs through a reduction of lactate, lactate/pyruvic retio, LDH activity, normalization of the level of glycogen, glucose, pyruvate.
authors.forename: V V
authors.initials: VV
authors.lastname: Sachok
authors.forename: M A
authors.initials: MA
authors.lastname: Mokhort
mesh_terms: D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001786:Blood Glucose / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000138:chemical synthesis / Q000494:pharmacology*; D009202:Cardiomyopathies / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D004095:Dihydropyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D004317:Doxorubicin; D005260:Female; D006003:Glycogen / Q000097:blood; D054879:Halogenation; D007770:L-Lactate Dehydrogenase / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008297:Male; D019289:Pyruvic Acid / Q000097:blood; D051381:Rats
chemical_list: D001786:Blood Glucose; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D017311:Amlodipine; D019344:Lactic Acid; C038806:1,4-dihydropyridine; D004317:Doxorubicin; D019289:Pyruvic Acid; D006003:Glycogen; D007770:L-Lactate Dehydrogenase