title: On the necessity of the idiotype network: studies with nude mice.
abstract: jerne suggested that a quintessentialfeature of the immune system was the recognition of self-idiotypes(1,2). Despite intense interest and investigation, the concept remains a hypothesis. Here the authors discuss data which place in question the necessity of an idiotype network.
authors.affiliation: Basel Institute for Immunology (founded and supported by F. Hoffmann-La Roche and Co., Ltd, Basel, Switzerland) and Pharmaceutical Research Laboratories, Ciba-Geigy Ltd, Basel, Switzerland.
authors.forename: H M
authors.initials: HM
authors.lastname: Edinger
authors.forename: C H
authors.initials: CH
authors.lastname: Heusser