title: Switch for the necroptotic permeation pore.
abstract: The helical protein MLKL inserts into cell membranes and forms a permeation pore therein, resulting in cell death. In this issue of Structure, the article by Su and colleagues reports that helix 6 regulates the opening of the pore formed by preceding core helices.
authors.affiliation: Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address: colishin@iastate.edu.
authors.forename: Yeon-Kyun
authors.initials: YK
authors.lastname: Shin
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, Republic of Korea.
authors.forename: Jaewook
authors.initials: J
authors.lastname: Kim
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, Republic of Korea.
authors.forename: Yoosoo
authors.initials: Y
authors.lastname: Yang
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011494:Protein Kinases