title: A review of methods to synthesise 4'-substituted nucleosides.
abstract: Modified nucleosides have received a great deal of attention from the scientific community, either for use as therapeutic agents, diagnostic tools, or as molecular probes. Perhaps the most difficult position of a nucleoside to modify is the 4'-position. Chemists have developed innovative methods to achieve this in a stereoselective manner to allow incorporation of a variety of functional groups. This review provides a summary of the most commonly used or recently published methods for ribose, deoxy-ribose, 4'-thioribose, and carbocyclics.
authors.affiliation: Peakdale Molecular, Sheffield Road, Chapel-en-le-Frith, Derbyshire SK23 0PG, UK. mark.betson@peakdale.co.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Betson
authors.forename: Nigel
authors.initials: N
authors.lastname: Allanson
authors.forename: Philip
authors.initials: P
authors.lastname: Wainwright
mesh_terms: D000478:Alkylation; D060326:Chemistry Techniques, Synthetic; D003855:Deoxyribose / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis*; D012266:Ribose / Q000737:chemistry*; D013237:Stereoisomerism; D013865:Thioglycosides / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D013865:Thioglycosides; D003855:Deoxyribose; D012266:Ribose; C530825:balapiravir