title: Influence of plasma cortisol and other laboratory parameters on nonalcoholic Fatty liver disease.
abstract: The objective of the present study was to analyse the association between the plasma cortisol concentration and nonalcoholic fatty liver disease (NAFLD). A total of 1 326 subjects (age 18-65 years) were examined in the context of an epidemiological study of a population-based random sample. Medical history and anthropometric data of 662 women and 664 men were documented. In addition, laboratory examinations were performed and the fat concentration of the liver was estimated by ultrasound examination. Mean cortisol concentration in plasma was 260.4±156.8 nmol/l for women and 295.8±161.2 nmol/l for men. NAFLD was identified in 17.7% in women and 35.1% in men. Plasma cortisol concentration showed no association with the existence of NAFLD. NAFLD correlated positive with age, body-mass index (BMI), waist-to-hip-ratio (WHR), alanine aminotransferase (ALT), and triglycerides. The present study failed to establish any association of plasma cortisol concentrations and NAFLD.
authors.affiliation: Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Hubel
authors.affiliation: Department of diagnostic and interventional Radiology, University Hospital Ulm, Ulm, Germany.
authors.forename: S A
authors.initials: SA
authors.lastname: Schmidt
authors.affiliation: Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Mason
authors.affiliation: Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
authors.forename: M M
authors.initials: MM
authors.lastname: Haenle
authors.affiliation: Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Oeztuerk
authors.affiliation: Department of Internal Medicine II, University Hospital Ulm, Ulm, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.affiliation: Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore.
authors.forename: B O
authors.initials: BO
authors.lastname: Boehm
authors.affiliation: Department of Internal Medicine I, University Hospital Ulm, Ulm, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Kratzer
authors.affiliation: Department of diagnostic and interventional Radiology, University Hospital Ulm, Ulm, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Graeter
authors.affiliation: Institute of Epidemiology and Medical Biometry, Ulm, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Flechtner-Mors
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000000981:diagnostic imaging; D014280:Triglycerides / Q000097:blood*; D014463:Ultrasonography; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D014280:Triglycerides; D006854:Hydrocortisone