title: Trade-off between growth and immunity: role of brassinosteroids.
abstract: A balance between growth and immunity exists in plants. Recently, the growth-promoting hormones brassinosteroids (BR) have emerged as crucial regulators of the growth-immunity trade-off, although the molecular mechanisms underlying this role remained unclear. New evidence obtained from the model plant Arabidopsis thaliana points at an indirect crosstalk between BR signaling and immunity, mediated by the transcription factors BZR1 and HBI1, which suppress immunity upon BR perception. The core transcriptional cascade formed by BZR1 and HBI1 seems to act as a regulatory hub on which multiple signaling inputs impinge, ensuring effective fine-tuning of the trade-off between growth and immunity in a timely and cost-efficient manner.
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: rosa.lozano-duran@tsl.ac.uk.
authors.forename: Rosa
authors.initials: R
authors.lastname: Lozano-Durán
authors.affiliation: The Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, UK. Electronic address: cyril.zipfel@tsl.ac.uk.
authors.forename: Cyril
authors.initials: C
authors.lastname: Zipfel
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000254:growth & development* / Q000276:immunology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D060406:Brassinosteroids / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D060406:Brassinosteroids; D014157:Transcription Factors
keywords: BZR1; crosstalk; growth; immunity; trade-off; transcriptional regulation