title: Association of polymorphism of Lys589Glu Exo1 gene with the risk of colorectal cancer in the Polish population.
abstract: The incidence of colorectal cancer (CRC) is increasing from year to year. Despite intensive research CRC etiology remains unknown. Studies suggest that at the basis of the process of carcinogenesis can lie reduced efficiency of DNA repair mechanisms, often caused by polymorphisms in DNA repair genes. The aim of the study was to determine the relationship between gene polymorphism Lys589Glu of EXO1 gene and modulation of the risk of colorectal cancer in the Polish population. Determination of the molecular basis of carcinogenesis process and predicting increased risk will allow qualifying patients to increased risk group and including them in preventive program.
  
  
  METHODS
  The material used in study was blood collected from 130 patients diagnosed with colorectal cancer. The control group consisted of 135 healthy people. Genotyping was performed by TaqMan method.
  
  
  RESULTS
  The results obtained indicate that the genotype Lys/Glu is associated with an increased risk of colorectal cancer (OR 1.811, 95% Cl 1.031-3.181, p = 0.038).
  
  
  CONCLUSIONS
  On the basis of these results, we conclude that Exo1 gene polymorphism Lys589Glu may be associated with an increased risk of colorectal cancer.
authors.forename: Jacek
authors.initials: J
authors.lastname: Kabziński
authors.forename: Karolina
authors.initials: K
authors.lastname: Przybylowska
authors.forename: Michał
authors.initials: M
authors.lastname: Mik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sygut
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Dziki
authors.forename: Adam
authors.initials: A
authors.lastname: Dziki
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Majsterek
mesh_terms: D000483:Alleles; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D005090:Exodeoxyribonucleases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D015995:Prevalence; D012307:Risk Factors; D044465:White People / Q000235:genetics*
chemical_list: C114331:EXO1 protein, human; D005090:Exodeoxyribonucleases; D045643:DNA Repair Enzymes