title: The increase of carcinoembryonic antigen (CEA), high-sensitivity C-reactive protein, and neutrophil/lymphocyte ratio in Parkinson's disease.
abstract: The role of carcinoembryonic antigen (CEA) in Parkinson's disease (PD) has not been previously investigated. The aim of the present study was to evaluate the serum level of carcinoembryonic antigen, high-sensitivity C-reactive protein (hs-CRP), and Neutrophil/lymphocyte ratio (NLR) among patients with Parkinson's disease and to examine the relationship between these inflammatory markers. The cross-sectional design includes 51 patients with Parkinson's disease and 50 age- and sex-matched healthy controls. We investigated the differences in hs-CRP, CEA, and NLR levels between these two groups. CEA was significantly higher in PD patients relative to the control group (mean 2.40 ± 1.51 vs. 1.72 ± 0.87 (ng/mL), respectively; p = 0.015). Mean NLR was significantly higher in PD patients relative to the control group (mean 3.1 ± 1.3 vs. 2.1 ± 0.32, respectively; p < 0.001). Serum level of hs-CRP was higher in PD patients than in control group (mean 1.04 ± 0.62 and 0.54 ± 0.31, respectively; p < 0.01). Correlation analysis revealed significant correlation between hs-CRP, CEA, and Neutrophil/lymphocyte ratio (p < 0.05). This study demonstrates for the first time the association between CEA, hs-CRP, NLR, and PD. We found CEA, hs-CRP, and NLR levels to be significantly higher in the PD patients than in the normal controls.
authors.affiliation: Department of Neurology, Faculty of Medicine, Dicle University, 21280, Diyarbakir, Turkey, esrefakil@gmail.com.
authors.forename: Eşref
authors.initials: E
authors.lastname: Akıl
authors.forename: Aslıhan
authors.initials: A
authors.lastname: Bulut
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Kaplan
authors.forename: Hasan Hüseyin
authors.initials: HH
authors.lastname: Özdemir
authors.forename: Demet
authors.initials: D
authors.lastname: Arslan
authors.forename: Mehmet Ufuk
authors.initials: MU
authors.lastname: Aluçlu
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000097:blood*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010300:Parkinson Disease / Q000097:blood*; D012372:ROC Curve
chemical_list: D002272:Carcinoembryonic Antigen; D002097:C-Reactive Protein