title: Islet product characteristics and factors related to successful human islet transplantation from the Collaborative Islet Transplant Registry (CITR) 1999-2010.
abstract: The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations and transplants. This retrospective report analyzed 1017 islet isolation procedures performed for 537 recipients of allogeneic clinical islet transplantation in 1999-2010. This study describes changes in donor and islet isolation variables by era and factors associated with quantity and quality of final islet products. Donor body weight and BMI increased significantly over the period (p<0.001). Islet yield measures have improved with time including islet equivalent (IEQ)/particle ratio and IEQs infused. The average dose of islets infused significantly increased in the era of 2007-2010 when compared to 1999-2002 (445.4±156.8 vs. 421.3±155.4×0(3) IEQ; p<0.05). Islet purity and total number of β cells significantly improved over the study period (p<0.01 and <0.05, respectively). Otherwise, the quality of clinical islets has remained consistently very high through this period, and differs substantially from nonclinical islets. In multivariate analysis of all recipient, donor and islet factors, and medical management factors, the only islet product characteristic that correlated with clinical outcomes was total IEQs infused. This analysis shows improvements in both quantity and some quality criteria of clinical islets produced over 1999-2010, and these parallel improvements in clinical outcomes over the same period.
authors.affiliation: Schulze Diabetes Institute, Department of Surgery, University of Minnesota, Minneapolis, MN.
authors.forename: A N
authors.initials: AN
authors.lastname: Balamurugan
authors.forename: B
authors.initials: B
authors.lastname: Naziruddin
authors.forename: A
authors.initials: A
authors.lastname: Lockridge
authors.forename: M
authors.initials: M
authors.lastname: Tiwari
authors.forename: G
authors.initials: G
authors.lastname: Loganathan
authors.forename: M
authors.initials: M
authors.lastname: Takita
authors.forename: S
authors.initials: S
authors.lastname: Matsumoto
authors.forename: K
authors.initials: K
authors.lastname: Papas
authors.forename: M
authors.initials: M
authors.lastname: Trieger
authors.forename: H
authors.initials: H
authors.lastname: Rainis
authors.forename: T
authors.initials: T
authors.lastname: Kin
authors.forename: T W
authors.initials: TW
authors.lastname: Kay
authors.forename: S
authors.initials: S
authors.lastname: Wease
authors.forename: S
authors.initials: S
authors.lastname: Messinger
authors.forename: C
authors.initials: C
authors.lastname: Ricordi
authors.forename: R
authors.initials: R
authors.lastname: Alejandro
authors.forename: J
authors.initials: J
authors.lastname: Markmann
authors.forename: J
authors.initials: J
authors.lastname: Kerr-Conti
authors.forename: M R
authors.initials: MR
authors.lastname: Rickels
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Witkowski
authors.forename: A
authors.initials: A
authors.lastname: Posselt
authors.forename: P
authors.initials: P
authors.lastname: Maffi
authors.forename: A
authors.initials: A
authors.lastname: Secchi
authors.forename: T
authors.initials: T
authors.lastname: Berney
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Connell
authors.forename: B J
authors.initials: BJ
authors.lastname: Hering
authors.forename: F B
authors.initials: FB
authors.lastname: Barton
mesh_terms: D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D012042:Registries
keywords: Clinical research/practice; Organ Procurement and Transplantation Network (OPTN); diabetes: type 1; endocrinology/diabetology; health services and outcomes research; islet isolation; islet transplantation; pancreas/simultaneous pancreas-kidney transplantation; registry/registry analysis