title: The basis of autoimmunity in MRL-lpr/lpr mice: a role for self Ia-reactive T cells.
abstract: Murine models of systemic lupus eRythematosus (SLE) have significantly contributed to our understanding of human autoimmunity. One such strain, the MRL-lpr/lpr, spontaneously develops an autoimmune disease manifested clinically by arthritis, vasculitis, immune-complex glomerulonephritis and autoantibody production(1-3). In this article Yvonne Rosenberg and her colleagues suggest a theoretical basis for the development of autoimmunity in MRL-lpr/lpr mice.
authors.affiliation: Section on Cellular Immunology, Arthritis and Rheumatism Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20205, USA.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Rosenberg
authors.forename: A D
authors.initials: AD
authors.lastname: Steinberg
authors.forename: T J
authors.initials: TJ
authors.lastname: Santoro