title: Sertoli-Leydig cell tumors: hormonal profile after dynamic test with GnRH analogue: triptorelin represents a useful tool to evaluate tumoral hyperandrogenism.
abstract: We report the case of a 15-year-old woman with signs of hyperandrogenism affected by a Sertoli-Leydig cell tumor (SLCT). In our patient, blood analysis showed a high testosterone (T) level (T: 8.53 nmol/L; nv < 1.87 nmol/L) while the GnRH-analogue test demonstrated an exaggerated secretion of 17-hydroxyprogesterone (OHP), T, and androstenedione (A) by the ovary after stimulation. We compared the GnRH-analogue test of our patient with that obtained in a group of normal and healthy women (no. 8 subjects, 16-26 years old), men (no. 4 subjects, 18-28 years old), and in a group of PCOS patients with age and body weight compared. We found in our patient a value of OHP, 17-beta estradiol (E2) and T, from 2 to 18 times higher than healthy women. When we compared our patient with healthy men, we differently observed a comparable response of T. The response of our patient was also comparable with that observed in the PCOS group for E2. During the post-surgical follow up, the GnRH-analogue test of our patient showed a response of OHP, T, and E2 comparable with that of the PCOS group. The GnRH-analogue test is a useful tool to characterize steroidogenesis in SLCT.
authors.affiliation: Department of Medicine - Clinica Medica 3 .
authors.forename: J
authors.initials: J
authors.lastname: Turra
authors.forename: M
authors.initials: M
authors.lastname: Granzotto
authors.forename: M
authors.initials: M
authors.lastname: Gallea
authors.forename: D
authors.initials: D
authors.lastname: Faggian
authors.forename: L
authors.initials: L
authors.lastname: Conte
authors.forename: P
authors.initials: P
authors.lastname: Litta
authors.forename: R
authors.initials: R
authors.lastname: Vettor
authors.forename: R
authors.initials: R
authors.lastname: Mioni
mesh_terms: D000293:Adolescent; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D007986:Luteinizing Hormone / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications* / Q000473:pathology; D018310:Sertoli-Leydig Cell Tumor / Q000097:blood / Q000150:complications* / Q000473:pathology; D013739:Testosterone / Q000097:blood; D017329:Triptorelin Pamoate
chemical_list: D017329:Triptorelin Pamoate; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
keywords: GnRH-analogue test; Sertoli–Leydig cell tumor; hyperandrogenism; steroid secretion; tumoral steroidogenesis