title: Biodegradation performance of a chitosan coated magnesium-zinc-tricalcium phosphate composite as an implant.
abstract: A Mg-Zn-tricalcium phosphate composite with a chitosan coating was prepared in this investigation to study its biodegradation performance both in vitro and in vivo conditions. The in vitro test results show that the immersion corrosion rate, the pH values of the simulated body fluids and the released metal ion concentration of the chitosan coated composite are all lower than those of the uncoated composite. The in vitro cytotoxicity test shows that the chitosan coated specimens is safe for cellular applications. When the chitosan coated composite is tested in vivo, the concentration of metal ions from the composite observed in the venous blood of Zelanian rabbits is less than the uncoated composite specimens. The chitosan coating slows down the in vivo degradation of the composite after surgery. In vivo testing also indicates that the chitosan coated composite is harmless to important visceral organs, including the heart, kidneys, and liver of the rabbits. The new bone formation surrounding the chitosan coated composite implant shows that the composite improves the concrescence of the bone tissues. The chitosan coating is an effective corrosion resistant layer that reduces the hydrogen release of the implant composite, thereby decreasing the subcutaneous gas bubbles formed.
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: XiangYa Third Hospital, Central South University, Changsha, HuNan 410083, People's Republic of China and State Key Laboratory of Powder Metallurgy, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Liangjian
authors.initials: L
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, HuNan 410083, People's Republic of China and State Key Laboratory of Powder Metallurgy, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yu
authors.affiliation: XiangYa Third Hospital, Central South University, Changsha, HuNan 410083, People's Republic of China and State Key Laboratory of Powder Metallurgy, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Yilong
authors.initials: Y
authors.lastname: Dai
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Qiao
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, HuNan 410083, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000818:Animals; D001711:Biotransformation; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D002130:Calcium Phosphates / Q000378:metabolism* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D048271:Chitosan / Q000378:metabolism* / Q000633:toxicity; D020099:Coated Materials, Biocompatible / Q000009:adverse effects / Q000378:metabolism*; D003343:Corrosion; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000378:metabolism* / Q000633:toxicity; D051379:Mice; D019736:Prostheses and Implants / Q000009:adverse effects*; D011817:Rabbits; D015032:Zinc / Q000378:metabolism* / Q000633:toxicity
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D048271:Chitosan; D008274:Magnesium; D015032:Zinc; C018392:tricalcium phosphate