title: Bridging innate with adaptive immunity in transplantation: triggers, sensors, and modulators.
abstract: The molecular entities present on a cell or organ transplant that trigger the innate immune response and link to the adaptive immune system are increasingly recognized as a key influence on early graft function and for determining the microenvironment that will guide longer-term graft outcomes. The 2014 Beaune Seminar in Transplant Research discussed the evidence for triggers, sensors, and modulators of innate and adaptive immunity in response to alloantigens, challenged the conventional view, developed novel hypotheses, and highlighted the potential for therapeutic manipulation of these responses.
authors.affiliation: 1 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK. 2 Service de Néphrologie, Dialyse et Transplantation Rénale, Hôpital Nord, CHU de Saint-Etienne, France. 3 Department of Renal Transplantation and Clinical Immunology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France. 4 Department of Nephrology and Transplantation, University Hospital, Dijon, France. 5 Address correspondence to: Kathryn J. Wood, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Wood
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
authors.forename: Oliver
authors.initials: O
authors.lastname: Thaunat
authors.forename: Christiane
authors.initials: C
authors.lastname: Mousson
authors.forename: Gérard
authors.initials: G
authors.lastname: Rifle
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D003167:Complement Activation; D003586:Cytomegalovirus Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007155:Immunologic Factors / Q000502:physiology; D007519:Isoantigens; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D051192:Receptors, Pattern Recognition / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D007155:Immunologic Factors; D007519:Isoantigens; D051192:Receptors, Pattern Recognition