title: [A case of neuroendocrine carcinoma in a diverticulum of the bladder].
abstract: We report a case of neuroendocrine carcinoma in a diverticulum of the bladder. A 65-year-old Japanese woman visited our hospital with the chief complaint of gross hematuria. Cystoscopy revealed a non-papillary broad-based tumor in a diverticulum of the posterior wall. She underwent transurethral resection of bladder tumor (TURBT) and subsequently total cystectomy with ileal conduit on the diagnosis of an invasive urothelial carcinoma. There was no residual tumor in the surgical specimen. Immunohistochemistry of TUR specimens showed positive synaptophysin, chromogranin A, CD56 and high ratio of positive Ki-67. Finally, it was diagnosed as a neuroendocrine carcinoma of the bladder. To our knowledge, this is the second case report of the neuroendocrine tumor or small cell carcinoma in a diverticulum of the urinary bladder in the Japanese literature.
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Muramatsu
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Kent
authors.initials: K
authors.lastname: Kanao
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Shingo
authors.initials: S
authors.lastname: Morinaga
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Keishi
authors.initials: K
authors.lastname: Kajikawa
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Kobayashi
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Genya
authors.initials: G
authors.lastname: Nishikawa
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Yoshizawa
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Kato
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Masahito
authors.initials: M
authors.lastname: Watanabe
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Kenji
authors.initials: K
authors.lastname: Zennami
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Kogenta
authors.initials: K
authors.lastname: Nakamura
authors.affiliation: The Department of Urology, Aichi Medical University.
authors.forename: Makoto
authors.initials: M
authors.lastname: Sumitomo
mesh_terms: D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000601:surgery; D015653:Cystectomy; D004240:Diverticulum / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery