title: Inflammatory myopathy and interstitial lung disease in antisynthetase syndrome with PL-7 antibody.
abstract: We report a case of a 72-year-old Caucasian woman with PL-7 positive antisynthetase syndrome. Clinical presentation included interstitial lung disease, myositis, 'mechanic's hands' and dysphagia. As lung injury was the main concern, treatment consisted of prednisolone and cyclophosphamide. Complete remission with reversal of pulmonary damage was achieved, as reported by CT scan, pulmonary function tests and functional status.
authors.affiliation: Department of Cardiology, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
authors.forename: Sílvia
authors.initials: S
authors.lastname: Aguiar Rosa
authors.affiliation: Department of Internal Medicine, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Barreto
authors.affiliation: Department of Internal Medicine, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
authors.forename: Marisa
authors.initials: M
authors.lastname: Mariano
authors.affiliation: Department of Internal Medicine, Centro Hospitalar Lisboa Central, Lisbon, Portugal.
authors.forename: Isabel
authors.initials: I
authors.lastname: Baptista
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology; D003937:Diagnosis, Differential; D004576:Electromyography; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D009220:Myositis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D001323:Autoantibodies