title: [Clonidine poisoning in a child: a case report].
abstract: Clonidine poisoning's clinical feature is well documented in the medical literature, but the minimal toxic dose has not yet been established. The effectiveness of naloxone is also controversial. The authors describe a clonidine overdose in a 9-year-old boy (25 kg) during a growth hormone test: he received tenfold the prescribed clonidine dose (0.23 mg instead of 0.023 mg) with 6.2 mg betaxolol. About 40 min later, he became drowsy and then complained of low blood pressure, bradycardia, and myosis. By maintaining the Trendelenburg position, administering fluids as well as salbutamol and naloxone (three doses of 0.2 mg were required), he recovered and was discharged from the hospital on day 2. The minimal clonidine toxic dose, the clinical picture, and the effectiveness of naloxone administration are discussed in this paper.
authors.affiliation: Centre antipoison de Marseille, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France. Electronic address: corinne.schmitt@ap-hm.fr.
authors.forename: C
authors.initials: C
authors.lastname: Schmitt
authors.affiliation: Centre antipoison de Marseille, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France.
authors.forename: M
authors.initials: M
authors.lastname: Kervégant
authors.affiliation: Service de pédiatrie, centre hospitalier de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France.
authors.forename: Z
authors.initials: Z
authors.lastname: Ajaltouni
authors.affiliation: Service de pédiatrie, centre hospitalier de Toulouse, 330, avenue de Grande-Bretagne, 31059 Toulouse cedex 9, France.
authors.forename: M
authors.initials: M
authors.lastname: Tauber
authors.affiliation: Centre antipoison de Marseille, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: Tichadou
authors.affiliation: Centre antipoison de Marseille, hôpital Sainte-Marguerite, 270, boulevard Sainte-Marguerite, 13009 Marseille, France.
authors.forename: L
authors.initials: L
authors.lastname: de Haro
mesh_terms: D058647:Adrenergic alpha-2 Receptor Agonists / Q000506:poisoning*; D000420:Albuterol / Q000008:administration & dosage; D000959:Antihypertensive Agents / Q000506:poisoning*; D015784:Betaxolol / Q000008:administration & dosage / Q000506:poisoning; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D003000:Clonidine / Q000008:administration & dosage / Q000506:poisoning*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D062787:Drug Overdose / Q000175:diagnosis* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008508:Medication Errors; D009270:Naloxone / Q000008:administration & dosage
chemical_list: D058647:Adrenergic alpha-2 Receptor Agonists; D000959:Antihypertensive Agents; D009270:Naloxone; D003000:Clonidine; D015784:Betaxolol; D000420:Albuterol