title: Extramedullary hematopoiesis of the conjunctiva presenting as active systemic disease in a patient with myelofibrosis.
abstract: OBJECTIVE
  To report the clinicopathological correlation of extramedullary hematopoiesis (EMH) of the conjunctiva in a patient with a history of myelofibrosis.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  Elevated pink conjunctival lesions developed bilaterally in a 73-year-old man who had been treated for myelofibrosis for 13 years. EMH was detected in the examination of tissue from the lesion of the inferior fornix of the right eye.
  
  
  CONCLUSIONS
  The appearance of conjunctival lesions in a patient with myelofibrosis may indicate underlying pathology of EMH that may necessitate a change in systemic treatment of this condition.
authors.affiliation: *Departments of Ophthalmology and †Pathology, Beaumont Health System, Royal Oak, MI; and ‡Oakland University William Beaumont School of Medicine, Rochester, MI.
authors.forename: Nirupa
authors.initials: N
authors.lastname: Cuttler
authors.forename: David
authors.initials: D
authors.lastname: Heidemann
authors.forename: Christopher
authors.initials: C
authors.lastname: Cendrowski
authors.forename: Ali-Reza
authors.initials: AR
authors.lastname: Armin
authors.forename: Robert
authors.initials: R
authors.lastname: Folberg
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D015415:Biomarkers / Q000378:metabolism; D003131:Combined Modality Therapy; D003229:Conjunctival Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D005169:Factor VIII / Q000378:metabolism; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D007124:Immunoenzyme Techniques; D053612:Janus Kinases / Q000037:antagonists & inhibitors; D008297:Male; D009570:Nitriles; D009195:Peroxidase / Q000378:metabolism; D055728:Primary Myelofibrosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011720:Pyrazoles / Q000627:therapeutic use; D011743:Pyrimidines; D018714:Radiotherapy, Adjuvant; D014792:Visual Acuity
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D009570:Nitriles; D011720:Pyrazoles; D011743:Pyrimidines; C540383:ruxolitinib; C078147:F8 protein, human; D005169:Factor VIII; D009195:Peroxidase; D053612:Janus Kinases