title: A decreased serum omentin-1 level may be an independent risk factor for peripheral arterial disease.
abstract: OBJECTIVE
  Recent evidence suggests that omentin-1, a visceral adipose-derived cytokine, may play a role in atherosclerosis The aim of this study was to evaluate whether serum omentin-1 levels are associated with peripheral artery disease (PAD) and its severity.
  
  
  METHODS
  The present study was cross-sectional and observational. We enrolled 123 patients with PAD and 50 age-matched subjects without PAD. The cardiovascular risk factors, ankle-brachial index (ABI), and serum omentin-1 levels were assessed in all participants
  
  
  RESULTS
  Patients with PAD had significantly lower omentin-1 levels than those without PAD (206. ±48.4 vs. 345. ±80 ng/mL, respectively; 0.001). A correlation analysis revealed positive correlations between the omentin-1 level and the ABI ( 0.52, P=0.008). After adjusting for cardiovascular risk factors, a decreased omentin-1 level was found to be an independent predictor of both PAD and its severity as measured by ABI in multivariate logistic regression analysis.
  
  
  CONCLUSIONS
  The current study suggests a strong association between decreased serum omentin-1 levels and PAD and its severity. Thus, omentin-1 may be a novel biomarker for PAD.
authors.affiliation: Department of Cardiology, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey - fahrettin_oz@hotmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Onur
authors.forename: F
authors.initials: F
authors.lastname: Oz
authors.forename: S
authors.initials: S
authors.lastname: Yildiz
authors.forename: H
authors.initials: H
authors.lastname: Kuplay
authors.forename: C
authors.initials: C
authors.lastname: Yucel
authors.forename: S
authors.initials: S
authors.lastname: Sigirci
authors.forename: A
authors.initials: A
authors.lastname: Elitok
authors.forename: S
authors.initials: S
authors.lastname: Pilten
authors.forename: K
authors.initials: K
authors.lastname: Kasali
authors.forename: A
authors.initials: A
authors.lastname: Yasar Cizgici
authors.forename: V
authors.initials: V
authors.lastname: Erentug
authors.forename: H M
authors.initials: HM
authors.lastname: Dinckal
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D015536:Down-Regulation; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey
chemical_list: D015415:Biomarkers; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins