title: Response to Comment on "Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring".
abstract: Bambini-Junior et al. questioned whether our treatment in two rodent models of autism has a long-lasting effect into adulthood. In response, we show that bumetanide treatment around delivery attenuates autistic behavioral features in adult offspring. Therefore, the polarity of γ-aminobutyric acid (GABA) actions during delivery exerts long-lasting priming actions after birth.
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Sanaz
authors.initials: S
authors.lastname: Eftekhari
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. On leave from Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Amene
authors.initials: A
authors.lastname: Shahrokhi
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France.
authors.forename: Vera
authors.initials: V
authors.lastname: Tsintsadze
authors.affiliation: Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France.
authors.forename: Romain
authors.initials: R
authors.lastname: Nardou
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France.
authors.forename: Corinne
authors.initials: C
authors.lastname: Brouchoud
authors.affiliation: Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France.
authors.forename: Magali
authors.initials: M
authors.lastname: Conesa
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France.
authors.forename: Nail
authors.initials: N
authors.lastname: Burnashev
authors.affiliation: Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France.
authors.forename: Diana C
authors.initials: DC
authors.lastname: Ferrari
authors.affiliation: Mediterranean Institute of Neurobiology (INMED), U901, INSERM, Marseille, France. UMR 901, Aix-Marseille University, Marseille, France. Neurochlore, Campus Scientifique de Luminy, 163 Route de Luminy, Marseille, France. yehezkel.ben-ari@inserm.fr.
authors.forename: Yehezkel
authors.initials: Y
authors.lastname: Ben-Ari
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000139:chemically induced* / Q000235:genetics*; D019610:Cytoprotection; D005260:Female; D010121:Oxytocin / Q000378:metabolism*; D011247:Pregnancy; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D010121:Oxytocin; D005680:gamma-Aminobutyric Acid