title: Counting or chunking? Mathematical and heuristic abilities in patients with corticobasal syndrome and posterior cortical atrophy.
abstract: A growing amount of empirical data is showing that the ability to manipulate quantities in a precise and efficient fashion is rooted in cognitive mechanisms devoted to specific aspects of numbers processing. The analog number system (ANS) has a reasonable representation of quantities up to about 4, and represents larger quantities on the basis of a numerical ratio between quantities. In order to represent the precise cardinality of a number, the ANS may be supported by external algorithms such as language, leading to a "precise number system". In the setting of limited language, other number-related systems can appear. For example the parallel individuation system (PIS) supports a "chunking mechanism" that clusters units of larger numerosities into smaller subsets. In the present study we investigated number processing in non-aphasic patients with corticobasal syndrome (CBS) and posterior cortical atrophy (PCA), two neurodegenerative conditions that are associated with progressive parietal atrophy. The present study investigated these number systems in CBS and PCA by assessing the property of the ANS associated with smaller and larger numerosities, and the chunking property of the PIS. The results revealed that CBS/PCA patients are impaired in simple calculations (e.g., addition and subtraction) and that their performance strongly correlates with the size of the numbers involved in these calculations, revealing a clear magnitude effect. This magnitude effect was correlated with gray matter atrophy in parietal regions. Moreover, a numeral-dots transcoding task showed that CBS/PCA patients were able to take advantage of clustering in the spatial distribution of the dots of the array. The relative advantage associated with chunking compared to a random spatial distribution correlated with both parietal and prefrontal regions. These results shed light on the properties of systems for representing number knowledge in non-aphasic patients with CBS and PCA.
authors.affiliation: University of Pennsylvania, Perelman School of Medicine, Penn Frontotemporal Degeneration Center, Philadelphia, PA 19104, USA. Electronic address: spotorno@mail.med.upenn.edu.
authors.forename: Nicola
authors.initials: N
authors.lastname: Spotorno
authors.affiliation: University of Pennsylvania, Perelman School of Medicine, Penn Frontotemporal Degeneration Center, Philadelphia, PA 19104, USA.
authors.forename: Corey T
authors.initials: CT
authors.lastname: McMillan
authors.affiliation: University of Pennsylvania, Perelman School of Medicine, Penn Frontotemporal Degeneration Center, Philadelphia, PA 19104, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Powers
authors.affiliation: University of Pennsylvania, Department of Linguistics, Philadelphia, PA 19104, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Clark
authors.affiliation: University of Pennsylvania, Perelman School of Medicine, Penn Frontotemporal Degeneration Center, Philadelphia, PA 19104, USA.
authors.forename: Murray
authors.initials: M
authors.lastname: Grossman
mesh_terms: D000368:Aged; D001284:Atrophy / Q000473:pathology / Q000523:psychology*; D001479:Basal Ganglia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D000066506:Heuristics; D006801:Humans; D019359:Knowledge; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000523:psychology*; D009483:Neuropsychological Tests; D013577:Syndrome
keywords: Chunking; Corticobasal syndrome; Number knowledge; Parietal; Posterior cortical atrophy; Prefrontal