title: Meaning of visualizing retinal cone mosaic on adaptive optics images.
abstract: OBJECTIVE
  To explore the anatomic correlation of the retinal cone mosaic on adaptive optics images.
  
  
  METHODS
  Retrospective nonconsecutive observational case series.
  
  
  METHODS
  A retrospective review of the multimodal imaging charts of 6 patients with focal alteration of the cone mosaic on adaptive optics was performed. Retinal diseases included acute posterior multifocal placoid pigment epitheliopathy (n = 1), hydroxychloroquine retinopathy (n = 1), and macular telangiectasia type 2 (n = 4). High-resolution retinal images were obtained using a flood-illumination adaptive optics camera. Images were recorded using standard imaging modalities: color and red-free fundus camera photography; infrared reflectance scanning laser ophthalmoscopy, fluorescein angiography, indocyanine green angiography, and spectral-domain optical coherence tomography (OCT) images.
  
  
  RESULTS
  On OCT, in the marginal zone of the lesions, a disappearance of the interdigitation zone was observed, while the ellipsoid zone was preserved. Image recording demonstrated that such attenuation of the interdigitation zone co-localized with the disappearance of the cone mosaic on adaptive optics images. In 1 case, the restoration of the interdigitation zone paralleled that of the cone mosaic after a 2-month follow-up.
  
  
  CONCLUSIONS
  Our results suggest that the interdigitation zone could contribute substantially to the reflectance of the cone photoreceptor mosaic. The absence of cones on adaptive optics images does not necessarily mean photoreceptor cell death.
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Jacob
authors.affiliation: Clinical Investigation Center 1423, Centre Hospitalier National des Quinze-Vingts, Institut National de la santé et de la recherche médicale & Université Pierre et Marie Curie, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Paques
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Krivosic
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dupas
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Couturier
authors.affiliation: Institut d'Optique Graduate School - Centre National de la Recherche Scientifique - Université Paris 11, Palaiseau, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Kulcsar
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Ramin
authors.initials: R
authors.lastname: Tadayoni
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Massin
authors.affiliation: Assistance Publique-Hôpitaux de Paris AP-HP, Hôpital Lariboisière, Service d'Ophtalmologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France. Electronic address: agaudric@gmail.com.
authors.forename: Alain
authors.initials: A
authors.lastname: Gaudric
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D009887:Ophthalmoscopy / Q000379:methods; D055620:Optical Phenomena; D010781:Photography / Q000379:methods; D017949:Retinal Cone Photoreceptor Cells / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods