title: Endoscopic mucosal resection recurrence rate for colorectal lesions.
abstract: OBJECTIVE
  We aimed to evaluate the polyp recurrence rate after endoscopic mucosal resection (EMR) and factors contributing to increased recurrence.
  
  
  METHODS
  MEDLINE (from 1966 to 2013), the Cochrane Central Register of Controlled Trials, and the Scopus database were searched in December 2013. Studies evaluating the polyp recurrence rate after colonic EMR were included. All of the articles were assigned a quality score. Standard forms were used to extract data regarding study design, outcome measures, and adverse effects by two independent reviewers. We performed a meta-analysis with a random effects model. Separate analyses were performed for each main outcome by using odds ratio (OR) and risk difference. Heterogeneity was assessed by I(2) measure of inconsistency.
  
  
  RESULTS
  For the recurrence rate of colorectal lesions, 30 articles were included, with a total of 3404 patients. The polyp recurrence rate after EMR was 13.1%. Piecemeal resection was associated with a higher recurrence rate compared with en bloc resection (OR 4.39, 95% confidence interval 2.05-9.41; 14 studies). The use of argon plasma coagulation did not affect the polyp recurrence rate (OR 1.23, 95% confidence interval 0.39-3.88). Significant heterogeneity was present among studies.
  
  
  CONCLUSIONS
  The recurrence rate of colorectal polyps after EMR is reasonably low; however, piecemeal resection was associated with a higher recurrence rate than en bloc resection after EMR.
authors.affiliation: From the Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso.
authors.forename: Arleen M
authors.initials: AM
authors.lastname: Ortiz
authors.affiliation: From the Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso.
authors.forename: Patham
authors.initials: P
authors.lastname: Bhargavi
authors.affiliation: From the Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Zuckerman
authors.affiliation: From the Department of Internal Medicine, Division of Gastroenterology, Texas Tech University Health Sciences Center, El Paso.
authors.forename: Mohamed O
authors.initials: MO
authors.lastname: Othman
mesh_terms: D018256:Adenomatous Polyps / Q000601:surgery*; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000601:surgery*; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery*; D007417:Intestinal Polyps / Q000601:surgery*; D015233:Models, Statistical; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D016017:Odds Ratio; D016896:Treatment Outcome