title: Calcium concentration in hypoxic-ischemic encephalopathy during hypothermia.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between prognosis and the changes in serum-ionized calcium concentration in neonates with hypoxic-ischemic encephalopathy (HIE) before and during brain hypothermia (BHT).
  
  
  METHODS
  Serum samples were obtained from 16 HIE neonates who underwent BHT. All patients underwent developmental testing at 18 months of age.
  
  
  RESULTS
  Mean serum-ionized calcium concentration in the poor outcome group (developmental quotient [DQ], <80; nine infants) was significantly lower than in the good outcome group (DQ >80; seven infants), both immediately before and after 6 h of BHT. Mean serum-ionized calcium concentration significantly decreased in both groups for 6 h, and the lowest adjusted serum-ionized calcium during 6 h of BHT was <1.05 mmol/L, known as the cut-off value for poor outcome, in 57.1% of the good outcome group.
  
  
  CONCLUSIONS
  The influx of calcium into cells continues regardless of neurological prognosis during the early phase of BHT, but BHT might protect some high-risk patients against neurological damage at low adjusted serum-ionized calcium concentration.
authors.affiliation: Department of Neonatology, Gifu Prefectural General Medical Center, Gifu, Japan; Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan; Perinatal Medical Center, Kagoshima City Hospital, Kagoshima, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ibara
authors.forename: Takuya
authors.initials: T
authors.lastname: Tokuhisa
authors.forename: Eiji
authors.initials: E
authors.lastname: Hirakawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoneda
authors.forename: Kosuke
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Eiji
authors.initials: E
authors.lastname: Kato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Maede
authors.forename: Takako
authors.initials: T
authors.lastname: Kuwabara
mesh_terms: D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects*; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000209:etiology; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D002118:Calcium
keywords: asphyxia; calcium; hypothermia; hypoxia-ischemia; newborn