title: Formulation Design, Optimization and Pharmacodynamic Evaluation of Sustained Release Mucoadhesive Microcapsules of Venlafaxine HCl.
abstract: The objective of present research work was to design and characterize the venlafaxine HCl-loaded sodium alginate-based mucoadhesive microcapsules by ionic gelation technique using HPMC K100M as mucoadhesive polymer. The Placket-Burman Design was applied for preliminary screening of the formulations and systematic optimization by using Box-Behnken Design. The prepared microcapsules were characterized for drug content, entrapment efficiency, micromeritic properties, particle size, swelling index, mucoadhesive strength, in vitro drug release and in vivo antidepressant activity. FTIR and differential scanning calorimetry studies showed no incompatibility. Surface morphology studies revealed spherical nature of the prepared microcapsules. In vitro drug release studies revealed sustained release by diffusion mechanism. Further, the microcapsules were effective in reducing the depression induced by forced swimming test in Sprague-Dawley rats compared to the pure drug. The microcapsules were found to be stable under accelerated stability conditions, which suggest them as better alternative delivery systems for enhanced therapeutic efficacy of antidepressant drug, venlafaxine HCl.
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: S
authors.initials: S
authors.lastname: Swain
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: A
authors.initials: A
authors.lastname: Behera
authors.affiliation: School of Pharmaceutical Education and Research, Berhampur University, Bhanja Bihar, Berhampur-760 007, India.
authors.forename: S C
authors.initials: SC
authors.lastname: Dinda
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: C N
authors.initials: CN
authors.lastname: Patra
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: Sruti
authors.initials: S
authors.lastname: Jammula
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: S
authors.initials: S
authors.lastname: Beg
authors.affiliation: Department of Pharmaceutics, Roland Institute of Pharmaceutical Sciences, Khodasingi, Berhampur-760 010, India.
authors.forename: M E B
authors.initials: ME
authors.lastname: Rao
keywords: Antidepressant activity; in vitro drug release; mucosal drug delivery; optimization; sustained release