title: Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.
abstract: BACKGROUND
  The aim of this study was to investigate the value of serum gastric markers to differentiate between patients with precancerous lesions and nonatrophic chronic gastritis.
  
  
  METHODS
  Serum samples of 128 patients with dyspepsia who were candidates for endoscopic examination were tested for pepsinogen (PG I and PG II), PG I/II ratio, gastrin 17(G-17), anti-Helicobacter pylori (anti-H pylori ) and anti- CagA antibodies. Two sample t-tests, chi-square tests and Pearson's correlation analyses were used for analysis using SPSS (version 20).
  
  
  RESULTS
  PGI, PG I/II ratio values were decreased significantly in the precancerous lesion group (0.05, 0.001 respectively). The frequency of H pylori infection was significantly (p=0.03) different between the two groups ofthe study.
  
  
  CONCLUSIONS
  We suggest PGI and the PG I/II ratio as valuable markers for screening of premalignant gastric lesions.
authors.affiliation: Gastrointestinal and Liver Diseases Research Center (GLDRC), Guilan University of Medical Sciences, Rasht, IranE-mail : ghanaei@gums.ac.ir, ghanaie@yahoo.com.
authors.forename: Fariborz
authors.initials: F
authors.lastname: Mansour-Ghanaei
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Joukar
authors.forename: Yaghoub
authors.initials: Y
authors.lastname: Rajpout
authors.forename: Tolou
authors.initials: T
authors.lastname: Hasandokht
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D000942:Antigens, Bacterial / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D016481:Helicobacter Infections / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007492:Iran; D008297:Male; D020116:Pepsinogen A / Q000097:blood*; D020115:Pepsinogen C / Q000097:blood*; D011230:Precancerous Conditions / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D011379:Prognosis; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis / Q000209:etiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D015415:Biomarkers; D005755:Gastrins; C080866:cagA protein, Helicobacter pylori; C013550:gastrin 17; D020115:Pepsinogen C; D020116:Pepsinogen A