title: Utility of routine surveillance blood cultures in asymptomatic allogeneic hematopoietic stem cell transplant recipients with indwelling central venous catheters at a comprehensive cancer center.
abstract: BACKGROUND
  Many transplant centers obtain surveillance blood cultures (SBCs) from asymptomatic allogeneic hematopoietic stem cell transplant (allo-HCT) recipients with central venous catheters for early detection of potential blood stream infections. The aim of this study was to determine the utility of this practice.
  
  
  METHODS
  We conducted a retrospective study of all patients who underwent allo-HCT to determine the frequency, clinical significance, and costs associated with SBCs.
  
  
  RESULTS
  From 776 patients, 6,801 SBCs were obtained (median, 9 per patient). Most (96.89%) were negative. Of the 211 positive SBCs, 171 (81%) had minimal clinical significance. The remaining 40 positive cultures (19%) were considered potentially significant. The frequency of potentially significant SBCs was 5.1% for the entire cohort and 0.59% of all SBCs drawn.
  
  
  CONCLUSIONS
  All potentially significant cultures and some that were deemed to have minimal significance led to medical intervention, some of which were probably unnecessary. No adverse outcomes occurred in patients with positive SBCs for the first 30 days following the positive result, regardless of the pathogen isolated or the quantitative colony count. The frequency of clinically significant positive SBCs in asymptomatic adult allo-HCT recipients is very low. Routine use of this practice leads to some unnecessary medical interventions and added costs.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas - MD Anderson Cancer Center, Houston, TX; Internal Medicine Division, Faculty of Health Sciences, Ben-Gurion University, Beer Sheba, Israel. Electronic address: nesherke@bgu.ac.il.
authors.forename: Lior
authors.initials: L
authors.lastname: Nesher
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas - MD Anderson Cancer Center, Houston, TX.
authors.forename: Roy F
authors.initials: RF
authors.lastname: Chemaly
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas - MD Anderson Cancer Center, Houston, TX.
authors.forename: Dimpy P
authors.initials: DP
authors.lastname: Shah
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas - MD Anderson Cancer Center, Houston, TX.
authors.forename: Victor E
authors.initials: VE
authors.lastname: Mulanovich
authors.affiliation: Stem Cell Transplantation and Cellular Therapy, Division of Cancer Medicine, The University of Texas - MD Anderson Cancer Center, Houston, TX.
authors.forename: Chitra
authors.initials: C
authors.lastname: Hosing
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas - MD Anderson Cancer Center, Houston, TX.
authors.forename: Kenneth V I
authors.initials: KV
authors.lastname: Rolston
mesh_terms: D001769:Blood / Q000382:microbiology*; D055499:Catheter-Related Infections / Q000175:diagnosis* / Q000453:epidemiology*; D062905:Central Venous Catheters / Q000009:adverse effects*; D042241:Early Diagnosis; D062665:Epidemiological Monitoring; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000628:therapy*; D012189:Retrospective Studies
keywords: Asymptomatic; Blood culture; Surveillance; Transplant