title: Robust detection of individual forensic profiles in DNA mixtures.
abstract: For a forensic identification method to be admissible in international courts, the probability of false match must be quantified. For comparison of individuals against complex mixtures using a panel of single nucleotide polymorphisms (SNPs), the probability of a random man not excluded, P(RMNE) is one admissible standard. While the P(RMNE) of SNP alleles has been previously studied, it remains to be rigorously defined and calculated for experimentally genotyped mixtures. In this report, exact P(RMNE) values were calculated for a range of complex mixtures, verified with Monte Carlo simulations, and compared alongside experimentally determined detection probabilities.
authors.affiliation: URX, 168 South Park St., San Francisco, CA 94107, United States.
authors.forename: J
authors.initials: J
authors.lastname: Isaacson
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: E
authors.initials: E
authors.lastname: Schwoebel
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: A
authors.initials: A
authors.lastname: Shcherbina
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: D
authors.initials: D
authors.lastname: Ricke
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: J
authors.initials: J
authors.lastname: Harper
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: M
authors.initials: M
authors.lastname: Petrovick
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: J
authors.initials: J
authors.lastname: Bobrow
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: T
authors.initials: T
authors.lastname: Boettcher
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: B
authors.initials: B
authors.lastname: Helfer
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States.
authors.forename: C
authors.initials: C
authors.lastname: Zook
authors.affiliation: MIT Lincoln Laboratory, Bioengineering Systems and Technologies Group, 244 Wood St., Lexington, MA 02420, United States. Electronic address: wack@ll.mit.edu.
authors.forename: E
authors.initials: E
authors.lastname: Wack
mesh_terms: D000483:Alleles; D004247:DNA / Q000235:genetics*; D053803:Forensic Genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011336:Probability
chemical_list: D004247:DNA
keywords: DNA mixture; Random man not excluded (RMNE); Single nucleotide polymorphism (SNP)