title: [Indexes of immunity and local protection in humans with intestine dysbacteriosis].
abstract: OBJECTIVE
  Study indexes of immunity and local protection in humans with intestine dysbacteriosis.
  
  
  METHODS
  Qualitative and quantitative intestine microbiocenosis, content of gamma-interferon (EIA method) in coprofiltrates in 204 individuals were studied, data from immunograms of 123 individuals with bacteriologically confirmed dysbacteriosis were analyzed.
  
  
  RESULTS
  The presence of immune deficiency mainly by T-cell type was established in 92.7+/-2.4% of individuals with intestine dysbacteriosis. Significant variations in -interferon content in coprofiltrates of examined individuals was detected (from no less than 5 pcg/ml to 240 pcg/ml), a statistically significant dependence of gamma-interferon content in coprofiltrates on the number of opportunistic microbes and atypical escherichia (including hemolytic) in intestine microbiocenosis was determined.
  
  
  CONCLUSIONS
  The presence of T-cell type immune deficiency in individuals with intestine dysbacteriosis combined with a reduced local protection, and the content of gamma-interferon in coprofiltrates gives evidence not only on the reduction of local protection but also to some extent mirrors the degree of this reduction.
authors.forename: M N
authors.initials: MN
authors.lastname: Gapon
authors.forename: L N
authors.initials: LN
authors.lastname: Ternovskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Denisenko
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Zarubinsky
mesh_terms: D001419:Bacteria / Q000302:isolation & purification* / Q000472:pathogenicity; D064806:Dysbiosis / Q000097:blood / Q000276:immunology / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000097:blood / Q000150:complications / Q000276:immunology; D007371:Interferon-gamma / Q000097:blood*; D007422:Intestines / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D007371:Interferon-gamma