title: Fascin1 in carcinomas: Its regulation and prognostic value.
abstract: Previous cell biological studies demonstrate that the actin bundling protein fascin1 regulates cell motility, migration and invasion. Human studies demonstrate that fascin1 is upregulated in many epithelial cancers. This review gives a brief overview of the role of fascin1 in cell migration and invasion, but focuses mainly on the regulation and clinical relevance of fascin1 in epithelial cancers. Here, we propose fascin1 as a potent prognostic biomarker for breast, colorectal, esophageal cancers and head and neck squamous cell carcinomas. Fascin1 may also be an attractive drug target against these carcinomas in the future, but more studies are needed.
authors.affiliation: School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.|Medical Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, NSW2170, New South Wales, Australia.
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, Scotland, United Kingdom.
authors.forename: Laura M
authors.initials: LM
authors.lastname: Machesky
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism*; D009361:Neoplasm Invasiveness / Q000473:pathology; D011379:Prognosis
chemical_list: D008840:Microfilament Proteins
keywords: carcinomas; fascin1; prognostic marker