title: Global mortality from conditions with skin manifestations.
abstract: BACKGROUND
  Global Burden of Disease Study is a research database containing systematically compiled information from vital statistics and epidemiologic literature to inform research, public policy, and resource allocation.
  
  
  OBJECTIVE
  We sought to compare mortality among conditions with skin manifestations in 50 developed and 137 developing countries from 1990 to 2010.
  
  
  METHODS
  This was a cross-sectional study to calculate mean age-standardized mortality (per 100,000 persons) across countries for 10 disease categories with skin manifestations. We compared differences in mortality from these disorders by time period (year 1990 vs year 2010) and by developing versus developed country status.
  
  
  RESULTS
  Melanoma death rates were 5.6 and 4.7 times greater in developed compared with developing countries in 1990 and 2010, respectively. Measles death rates in 1990 and 2010 were 345 and 197 times greater in developing countries, and corresponding syphilis death rates were 33 and 45 times greater.
  
  
  CONCLUSIONS
  Inability to adjust for patient-, provider-, and geographic-level confounders may limit the accuracy and generalizability of these results.
  
  
  CONCLUSIONS
  The mortality burden from skin-related conditions differs between developing and developed countries, with the greatest differences observed for melanoma, measles, and syphilis. These results may help prioritize and optimize efforts to prevent and treat these disorders.
authors.affiliation: Georgetown University School of Medicine, Washington, District of Columbia.
authors.forename: Lindsay N
authors.initials: LN
authors.lastname: Boyers
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: Chante
authors.initials: C
authors.lastname: Karimkhani
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Naghavi
authors.affiliation: Department of Integrative Physiology, University of Colorado, Boulder, Colorado.
authors.forename: David
authors.initials: D
authors.lastname: Sherwood
authors.affiliation: Department of Biostatistics and Epidemiology and Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
authors.forename: David J
authors.initials: DJ
authors.lastname: Margolis
authors.affiliation: Department of Dermatology, Kings College Hospital National Health Service Trust, London, United Kingdom.
authors.forename: Roderick J
authors.initials: RJ
authors.lastname: Hay
authors.affiliation: Center of Evidence-based Dermatology, University of Nottingham, Nottingham, United Kingdom.
authors.forename: Hywel C
authors.initials: HC
authors.lastname: Williams
authors.affiliation: Department of Dermatology, Azienda Ospedaliera papa Giovanni XXIII, Bergamo, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Naldi
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington.
authors.forename: Luc E
authors.initials: LE
authors.lastname: Coffeng
authors.affiliation: Dermatoepidemiology Unit, US Department of Veterans Affairs Medical Center Providence, Providence, Rhode Island; Department of Dermatology, Rhode Island Hospital, Providence, Rhode Island; Departments of Dermatology and Epidemiology, Brown University, Providence, Rhode Island.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Weinstock
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado.
authors.forename: Cory A
authors.initials: CA
authors.lastname: Dunnick
authors.affiliation: University of Colorado School of Medicine, Aurora, Colorado.
authors.forename: Hannah
authors.initials: H
authors.lastname: Pederson
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington.
authors.forename: Theo
authors.initials: T
authors.lastname: Vos
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Dermatology Service, US Department of Veterans Affairs, Eastern Colorado Health Care System, Denver, Colorado; Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address: robert.dellavalle@ucdenver.edu.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Dellavalle
mesh_terms: D017677:Age Distribution; D002280:Basal Cell Carcinoma / Q000401:mortality*; D002294:Carcinoma, Squamous Cell / Q000401:mortality*; D002644:Chickenpox / Q000401:mortality; D003430:Cross-Sectional Studies; D003715:Dengue / Q000401:mortality; D019049:Developed Countries; D003906:Developing Countries; D014943:Global Health; D006801:Humans; D008457:Measles / Q000401:mortality; D008545:Melanoma / Q000401:mortality*; D012878:Skin Neoplasms / Q000401:mortality*; D013587:Syphilis / Q000401:mortality
keywords: Global Burden of Disease Study 2010; basal cell carcinoma; burden of disease; dermatology; developed countries; developing countries; epidemiology; measles; melanoma; mortality; nonmelanoma skin cancer; rate of death; squamous cell carcinoma; syphilis