title: The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis.
abstract: A systematic review and meta-analysis were performed to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Studies that compared women who were impregnated by donor and partner sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies. Conception using donor sperm was associated with an increased risk of preeclampsia (odds ratio [OR] 1.63, 95% CI 1.36-1.95) compared with using a partner's sperm. No difference was observed in the risk of gestational hypertension (OR 0.94, 95% CI 0.43-2.03). In conclusion, pregnancies achieved by donor sperm significantly increase the risk of preeclampsia, although the underlying mechanisms remain unclear. Additional studies are required to confirm these findings.
authors.affiliation: Department of Obstetrics and Gynaecology, Hospital del Mar, Parc de Salut Mar de Barcelona, Barcelona, Spain. Electronic address: mgonzalezcomadran@parcdesalutmar.cat.
authors.forename: Mireia
authors.initials: M
authors.lastname: González-Comadran
authors.affiliation: International Master in Reproductive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: jaurresta@yahoo.com.mx.
authors.forename: Julio
authors.initials: J
authors.lastname: Urresta Avila
authors.affiliation: International Master in Reproductive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: alejo_saavedra@hotmail.com.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Saavedra Tascón
authors.affiliation: International Master in Reproductive Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: radharanij@hotmail.com.
authors.forename: Radhanari
authors.initials: R
authors.lastname: Jimenéz
authors.affiliation: Institute of Biomedical Research, IIB Sant Pau, Barcelona, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. Electronic address: tsc@cochrane.es.
authors.forename: Ivan
authors.initials: I
authors.lastname: Solà
authors.affiliation: Centro de Infertilidad y Reproducción Humana (CIRH), Barcelona, Spain. Electronic address: mbrassesco@cirh.es.
authors.forename: Mario
authors.initials: M
authors.lastname: Brassesco
authors.affiliation: Department of Obstetrics and Gynaecology, Hospital del Mar, Parc de Salut Mar de Barcelona, Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: rcarreras@parcdesalutmar.cat.
authors.forename: Ramón
authors.initials: R
authors.lastname: Carreras
authors.affiliation: Department of Obstetrics and Gynaecology, Hospital del Mar, Parc de Salut Mar de Barcelona, Barcelona, Spain; Centro de Infertilidad y Reproducción Humana (CIRH), Barcelona, Spain; Universitat Autònoma de Barcelona, Barcelona, Spain. Electronic address: macheca@hospitaldelmar.cat.
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Checa
mesh_terms: D003075:Coitus; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000453:epidemiology; D007316:Insemination, Artificial, Heterologous; D007317:Insemination, Artificial, Homologous; D008297:Male; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D012307:Risk Factors; D013094:Spermatozoa; D014019:Tissue Donors
keywords: Donor sperm; Gestational hypertension; Infertility; Meta-analysis; Preeclampsia