title: MicroRNAs expression profile in CCR6(+) regulatory T cells.
abstract: Backgroud. CCR6(+) CD4(+) regulatory T cells (CCR6(+) Tregs), a distinct Tregs subset, played an important role in various immune diseases. Recent evidence showed that microRNAs (miRNAs) are vital regulators in the function of immune cells. However, the potential role of miRNAs in the function of CCR6(+) Tregs remains largely unknown. In this study, we detected the expression profile of miRNAs in CCR6(+) Tregs. Materials and Methods. The expression profile of miRNAs as well as genes in CCR6(+) Tregs or CCR6(-) Tregs from Balb/c mice were detected by microarray. The signaling pathways were analyzed using the Keggs pathway library. Results. We found that there were 58 miRNAs significantly upregulated and 62 downregulated up to 2 fold in CCR6(+) Tregs compared with CCR6(-) Tregs. Moreover, 1,391 genes were observed with 3 fold change and 20 signaling pathways were enriched using the Keggs pathway library. Conclusion. The present data showed CCR6(+) Tregs expressed specific miRNAs pattern, which provides insight into the role of miRNAs in the biological function of distinct Tregs subsets.
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Yongju
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Medical Physics, Zunyi Medical College, Guizhou, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Yijin
authors.initials: Y
authors.lastname: Tao
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Guo
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Nalin
authors.initials: N
authors.lastname: Qin
authors.affiliation: Department of Immunology, Zunyi Medical College, Guizhou, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
keywords: CCR6; Microarray; Regulatory T cell; miRNAs