title: Increased serum alkaline phosphatase and serum phosphate as predictors of mortality after stroke.
abstract: BACKGROUND
  Serum Alkaline phosphatase (ALP) & phosphate are considered to be indicators of vascular calcification. Link between bone metabolism, vascular calcification, cardiovascular events have been well studied in chronic kidney disease and ischemic heart disease.
  
  
  OBJECTIVE
  To determine that increased serum phosphate and alkaline phosphatase are predictors of mortality rates and recurrent vascular events in stroke.
  
  
  METHODS
  Sixty patients admitted with acute stroke (ischemic & haemorrhagic) were included in the study. Their baseline clinical characteristics and biochemical parameters including serum ALP and phosphate were noted. All patients were followed up for a period of one year. The all- cause mortality, the mortality due to cardiovascular events and recurrent vascular events without death were noted during the follow up. Statistical analyses were done to look for any correlation between mortality and baseline levels of serum ALP and phosphate.
  
  
  RESULTS
  Of the 60 patients, 8 (13.3%) patients were lost for follow up. Fourteen (26.9%) patients died; of which 12 deaths were due to vascular causes and 2 deaths were due to non vascular causes. Increasing levels of serum ALP and phosphate correlated with all cause mortality and recurrent vascular events without death Conclusion: Serum ALP and phosphate prove to be cost effective prognostic indicator of mortality and recurrent vascular events in stroke. This finding has to be confirmed with studies including larger population. Further research on ALP inhibitors, Vitamin D analogues and phosphate binders to improve mortality in stroke population can be encouraged.
authors.affiliation: Resident, Department of Neurology, Bangalore Medical College & Research Institute , Bangalore, India .
authors.forename: Pratibha
authors.initials: P
authors.lastname: S
authors.affiliation: Associate Professor, Department of Neurology, Bangalore Medical College & Research Institute , Bangalore, India .
authors.forename: Praveen-Kumar
authors.initials: PK
authors.lastname: S
authors.affiliation: Professor, Department of Neurology, Bangalore Medical College & Research Institute , Bangalore, India .
authors.forename: Agadi
authors.initials: A
authors.lastname: Jb
keywords: Alkaline phosphatase; Phosphate; Recurrent vascular events; Vascular calcification