title: Impact of estimated HDL particle size via the ratio of HDL-C and apoprotein A-I on short-term prognosis of diabetic patients with stable coronary artery disease.
abstract: BACKGROUND
  Revascularization and statin therapy are routinely used in the management of stable coronary artery disease. However, it is unclear whether the estimated high-density lipoprotein (HDL) particle size (eHDL-S), the ratio of HDL cholesterol (HDL-C) to apoprotein A-I (apoA-I), is associated with the clinical outcomes of diabetic patients with stable coronary artery disease (CAD).
  
  
  METHODS
  We performed a prospective cohort study of 328 patients diagnosed with stable CAD by coronary angiography. Patients were followed up for a mean duration of 12 months. The patients were divided into three groups by the tertiles of eHDL-S: low eHDL-S (< 0.71, n = 118); intermediate eHDL-S (0.71-0.79, n = 111); and high eHDL-S (> 0.79, n = 99). The associations between the baseline eHDL-S and short-term outcomes were evaluated using the Kaplan-Meier method and Cox proportional regression.
  
  
  RESULTS
  The low eHDL-S group had higher triglyceride, hemoglobin A1c, uric acid, and leukocyte count than the other groups. During the follow-up period, 47/328 patients experienced a pre-specified outcome. According to the Kaplan-Meier analysis, the incidence of pre-specified outcomes was lower in the high eHDL-S group (P = 0.04). However, eHDL-S was not independently associated with adverse outcomes in Cox proportional hazards regression (hazard ratio (HR): 0.23, 95% confidence interval (95% CI): 0.01-11.24, P = 0.493).
  
  
  CONCLUSIONS
  Although the eHDL-S was associated with inflammatory biomarkers, it was not independently associated with the short-term prognosis of diabetic patients with stable CAD in the era of revascularization and potent statin therapy.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Hong
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.affiliation: Department of Cardiology, Guang-Ci Hospital of Wuhan University & the Fifth Hospital of Wuhan, Wuhan 430050, Hubei Province, China.
authors.forename: Song-Hui
authors.initials: SH
authors.lastname: Luo
authors.affiliation: Department of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Li
keywords: Apoprotein A-I; Coronary artery disease; Diabetes mellitus; High-density lipoprotein; Outcome