title: Possible role of Eptifibatide drip in-patient with aneurysmal subarachnoid hemorrhage in vasospasm prevention.
abstract: OBJECTIVE
  Approximately 18,000 patients suffer from a subarachnoid hemorrhage (SAH) in the United States annually. SAH is a form of stroke and comprises 1%-5% of all strokes. Nearly 50% of all SAH cases end in fatality within 30 days of presentation; one of eight patients die before reaching a hospital. Those who survive often have neurological or cognitive impairment.
  
  
  METHODS
  This case report describes the course of two patients who presented to the emergency department with aneurismal subarachnoid hemorrhage and received external ventricular drainage and endovascular treatment of their aneurysm.
  
  
  RESULTS
  Both patients required treatment with Eptifibatide drip after endovascular approach and their SAH in the basal cisterns resolved by day 5. Neither patient developed signs of clinical or subclinical vasospasm.
  
  
  CONCLUSIONS
  Eptifibatide drip facilitated resolution of the thick clot in the subarachnoid space early enough to eliminate the direct toxicity of oxyhemoglobin on the cerebral arteries and arachnoid granulations, thus preventing vasospasm and eliminating the necessity for a long-term shunt.
authors.affiliation: Contributed equally to this work.
authors.forename: Haitham
authors.initials: H
authors.lastname: Dababneh
authors.affiliation: University of Texas Health Science Center, Houston, TX 77030, USA ; Contributed equally to this work.
authors.forename: Waldo
authors.initials: W
authors.lastname: Guerrero
authors.affiliation: Stroke & Neurovascular Center at JFK Neuroscience Institute, Edison, NJ 08818, USA.
authors.forename: Siddhart
authors.initials: S
authors.lastname: Mehta
authors.affiliation: Stroke & Neurovascular Center at JFK Neuroscience Institute, Edison, NJ 08818, USA.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Moussavi
authors.affiliation: Stroke & Neurovascular Center at JFK Neuroscience Institute, Edison, NJ 08818, USA.
authors.forename: Jawad F
authors.initials: JF
authors.lastname: Kirmani
keywords: Aneurismal subarachnoid hemorrhage; aneurismal coils; endovascular therapy; intracranial stent; stroke; transcranial Doppler