title: Micrometer size rod formed by secondary self assembly of omeprazole with α- and β-cyclodextrins.
abstract: Self assembly of α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) micro rods induced by omeprazole (OMP) were observed by SEM and TEM. OMP/CD inclusion complexes have formed the secondary self assembly micro meter size rod like structure. This structure was driven by the intermolecular hydrogen bonding as well as van der Waals forces. Both forces induced the ordered assembly and arrangement of OMP/CD inclusion complexes, whereas CD molecules acted as molecular bricks. The OMP/CD inclusion complexes primary assembled form individual nanorods and then secondary self aggregate nanorods were form a micro meter rod structure. The results indicate that inter-nanotubular hydrogen bonding plays a crucial role in the formation of the self assembled micro rods. The inclusion complexes were also characterized using FT-IR, DSC, powder XRD, (1)H NMR, absorption, fluorescence, life time measurements and molecular modeling methods.
authors.affiliation: Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India. Electronic address: drrajendiran@rediffmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Rajendiran
authors.affiliation: Department of Chemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
authors.forename: G
authors.initials: G
authors.lastname: Venkatesh
mesh_terms: D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry; D009853:Omeprazole / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D011208:Powders; D047391:alpha-Cyclodextrins; D047392:beta-Cyclodextrins; D009853:Omeprazole
keywords: Cyclodextrin; Inclusion complex; Molecular modeling; Nanorod; Omeprazole; Supramolecular architecture