title: [DIO2, TPO, CYP1A1 AND CYP1A2 gene polymorphism in women with thyroid disease].
abstract: The analysis of polymorphisms of genes CYP1A1 (2454A > G,-3798T> C); CYP1A2 (-163C > A,-2467delT); TPO (2173A > C, 769G > T); DIO2 (274A > G) in women from the oil organic synthesis plant and the control group with thyroid disease (autoimmune thyroiditis and nodular goiter) has been performed. Molecular genetic markers of predisposition to the development of thyroid disease are: GG genotype and allele G gene DIO2 (274A > G), CT and CC genotypes of the gene CYP1A1 (-3798T > C), associated with the development of nodular goiter, and DD genotypes TD CYP1A2 gene (-2467delT), associated with the development of autoimmune thyroiditis. There was shown an association of polymorphic variants of the gene DIO2 (274A > G) with elevated levels of antibodies to TPO and TPO gene (2173A > C) with elevated levels of free T4.
authors.forename: O V
authors.initials: OV
authors.lastname: Kochetova
authors.forename: M K
authors.initials: MK
authors.lastname: Gaynullina
authors.forename: T V
authors.initials: TV
authors.lastname: Viktorova
mesh_terms: D000328:Adult; D000483:Alleles; D001324:Autoantigens / Q000235:genetics*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007453:Iodide Peroxidase / Q000235:genetics*; D033862:Iron-Binding Proteins / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013959:Thyroid Diseases / Q000235:genetics* / Q000503:physiopathology; D000097564:Iodothyronine Deiodinase Type II
chemical_list: D001324:Autoantigens; D019363:Cytochrome P-450 CYP1A1; D019388:Cytochrome P-450 CYP1A2; D007453:Iodide Peroxidase; D033862:Iron-Binding Proteins; D000097564:Iodothyronine Deiodinase Type II; C056658:TPO protein, human