title: [Individualized treatment of osteoarticular infections in children may shorten the treatment course].
abstract: Older studies have suggested that antibiotic treatment for less than 21 days in children with osteoarticular infections is associated with relapse, and therefore traditionally these infections have been treated for six weeks with an intravenous phase of one week. However, four new prospective studies suggest that if the duration of treatment is individualized and made dependent on the clinical response and the C-reactive protein level, the treatment course may be shortened substantially without increasing the risk of relapse or sequelae. This article reviews older and newer literature on this subject.
authors.affiliation: Børneafdelingen, Nykøbing F. Sygehus, Fjordvej 15, 4800 Nykøbing F. kimk@dadlnet.dk.
authors.forename: Kim
authors.initials: K
authors.lastname: Kristensen
authors.forename: Jesper
authors.initials: J
authors.lastname: Andersen
authors.forename: Kjeld Gade
authors.initials: KG
authors.lastname: Hansen
authors.forename: Thomas
authors.initials: T
authors.lastname: Hoffmann
authors.forename: Jørgen
authors.initials: J
authors.lastname: Kurtzhals
authors.forename: Ulrikka
authors.initials: U
authors.lastname: Nygaard
authors.forename: Freddy Karup
authors.initials: FK
authors.lastname: Pedersen
mesh_terms: D000208:Acute Disease; D061605:Administration, Intravenous; D000284:Administration, Oral; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy*; D002097:C-Reactive Protein / Q000032:analysis; D002648:Child; D004334:Drug Administration Schedule; D006801:Humans; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy*; D057285:Precision Medicine; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein