title: The G protein-coupled receptor GPR162 is widely distributed in the CNS and highly expressed in the hypothalamus and in hedonic feeding areas.
abstract: The Rhodopsin family is a class of integral membrane proteins belonging to G protein-coupled receptors (GPCRs). To date, several orphan GPCRs are still uncharacterized and in this study we present an anatomical characterization of the GPR162 protein and an attempt to describe its functional role. Our results show that GPR162 is widely expressed in GABAergic as well as other neurons within the mouse hippocampus, whereas extensive expression is observed in areas related to energy homeostasis and hedonic feeding such as hypothalamus, amygdala and ventral tegmental area, regions known to be involved in the regulation of palatable food consumption.
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Vanni
authors.initials: V
authors.lastname: Caruso
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Hägglund
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Luca
authors.initials: L
authors.lastname: Badiali
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Sonchita
authors.initials: S
authors.lastname: Bagchi
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Sahar
authors.initials: S
authors.lastname: Roshanbin
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Tauseef
authors.initials: T
authors.lastname: Ahmad
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden.
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
authors.affiliation: Department of Neuroscience, Functional Pharmacology, Uppsala University, Husargatan 3, Uppsala 75124, Sweden. Electronic address: Robert.Fredriksson@neuro.uu.se.
authors.forename: Robert
authors.initials: R
authors.lastname: Fredriksson
mesh_terms: D000679:Amygdala / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D002490:Central Nervous System / Q000378:metabolism*; D005247:Feeding Behavior; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D034741:RNA, Small Interfering / Q000235:genetics; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D017557:Ventral Tegmental Area / Q000378:metabolism* / Q000502:physiology
chemical_list: C000594931:GPR162 protein, mouse; D034741:RNA, Small Interfering; D043562:Receptors, G-Protein-Coupled
keywords: Energy homeostasis; GPCRs; GPR162; Hedonic feeding