title: Does cyclosporine act in vivo as it does in vitro?
abstract: Cyclosporine aborts the activation of lymphocytes in vitro before DNA synthesis begins, yet there is also compelling evidence that lymphocytes can become primed, i.e. presumably proliferate in vivo, under the cover of immunosuppressive levels of the drug. Here, Gerry Klaus and Patricia Chisholm discuss the possibility that cyclosporine has a different mode of action in vivo and in vitro.
authors.affiliation: Division of Immunology, National Institute for Medical Research, London NW7 1AA, UK; Immunology Department Chelsea College, University of London, London SW3 6LX, UK.
authors.forename: G G
authors.initials: GG
authors.lastname: Klaus
authors.affiliation: Division of Immunology, National Institute for Medical Research, London NW7 1AA, UK; Immunology Department Chelsea College, University of London, London SW3 6LX, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: Chisholm