title: LOXL1-associated candidate epithelial pathomechanisms in exfoliation glaucoma.
abstract: Results of the present study support ocular epithelia-specific LOXL1 functions in exfoliation glaucoma that may include both dysregulated extracellular matrix cross-linking activity and cellular mechanisms involving a role for LOXL1, in direct interaction with Snail1, in promoting epithelial to mesenchymal transition and a potential shift towards fibrogenic epithelial cell phenotypes.
authors.affiliation: John A. Burns School of Medicine, University of Hawaii, Honolulu, HI.
authors.forename: Rozalia
authors.initials: R
authors.lastname: Laczko
authors.forename: Kornelia M
authors.initials: KM
authors.lastname: Szauter
authors.forename: Katalin
authors.initials: K
authors.lastname: Csiszar
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism*; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology*; D017889:Exfoliation Syndrome / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D005902:Glaucoma, Open-Angle / Q000378:metabolism*; D006801:Humans
chemical_list: D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human