title: Parallel artificial membrane permeability assay for blood-brain permeability determination of illicit drugs and synthetic analogues.
abstract: With the number of designer drugs on the streets rampantly on the rise, it's becoming more and more important to be able to rapidly characterize them in a biologically relevant way. Using a parallel artificial membrane permeability assay (PAMPA) to assess the blood brain barrier permeability has shown to be a high throughput way to compare new drugs with currently controlled substances via their effective permeability values. This combined with direct infusion electrospray ionization-mass spectrometry creates a rapid technique for characterization of new designer drugs. PAMPA has successfully determined the effective permeabilities of cocaine, methamphetamine, heroin, MDMA, and several tryptamine derivatives.
authors.affiliation: Department of Chemistry, University of North Texas, #305070 Denton, TX 76203, United States.
authors.forename: Kristina
authors.initials: K
authors.lastname: Clemons
authors.affiliation: Department of Chemistry, University of North Texas, #305070 Denton, TX 76203, United States.
authors.forename: Amanda
authors.initials: A
authors.lastname: Kretsch
authors.affiliation: Department of Chemistry, University of North Texas, #305070 Denton, TX 76203, United States. Electronic address: gverbeck@unt.edu.
authors.forename: Guido
authors.initials: G
authors.lastname: Verbeck
keywords: Blood–brain barrier; Drug analogues; ESI–MS; Illicit drugs; Parallel artificial membrane permeability assay