title: [The effect of comorbid headaches in patients with epilepsy on clinical pathomorphosis of the disease].
abstract: Of 404 adult patients with epilepsy (E) with a period of follow-up from 5 to 26 years (mean 8.5 +/- 3.0) a group of 168 people was distinguished by presence of comorbid headaches (HAs) of various types: by origin--primary and secondary, by relation to occurrence of epileptic seizures--inter- and periictal. In general, the presence of comorbid HA did not affect the prognosis for remission of epileptic seizures in patients of all etiologic groups (idiopathic, cryptogenic, and symptomatic). Primary HAs were mainly observed in cryptogenic and idiopathic E, and secondary--in symptomatic E. It is in the group of patients with symptomatic epilepsy and HAs the clinical pathomorphosis depending on the etiology of the disease has been marked. HA in patients with vascular E haven't worsen the prognosis of the disease: 86.7% of patients were in remission, indicating the positive clinical pathomorphosis of this form of E. At the same time, a negative long-term clinical pathomorphosis of symptomatic E was observed in comorbidity of HA with posttraumatic E, with mesial temporal sclerosis and with E due to the brain space-occupying lesions, or the consequences of their removal. In these cases the patients developed more often drug-resistance. Pseudo-resistance was observed in patients with E and HA in multiple sclerosis and in alcoholic E.
authors.forename: L B
authors.initials: LB
authors.lastname: Mar"ienko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015897:Comorbidity; D004827:Epilepsy / Q000145:classification / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006261:Headache / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000503:physiopathology*; D011379:Prognosis; D014455:Ukraine / Q000453:epidemiology