title: Benign imitation of malignancy: avoiding resection in immunoglobulin g4-related lung disease.
abstract: We report the case of a 32-year-old woman who presented with cough, pleuritic pain, and a solitary lung mass. Computed tomography demonstrated a 3.7-cm spiculated right lower lobe mass, and 18-fluoro-deoxy-glucose positron emission tomography/computed tomography demonstrated significant hypermetabolism, both most suggestive of invasive adenocarcinoma. The results of fine needle aspirate biopsy favored a benign inflammatory process. Video-assisted thoracoscopic surgery right lower lobectomy was performed, and histopathologic examination of the mass was consistent with immunoglobulin G4-related disease (IgG4-RD). A definitive diagnosis of IgG4-RD often requires correlating several nonspecific findings with surgical lung biopsy. We discuss important diagnostic and treatment considerations for pulmonary IgG4-RD.
authors.affiliation: Department of Thoracic Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hazzard
authors.affiliation: Department of Thoracic Surgery, Mount Sinai Medical Center, New York, New York.
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Wolf
authors.affiliation: Department of Pathology, Mount Sinai Medical Center, New York, New York.
authors.forename: Mary B
authors.initials: MB
authors.lastname: Beasley
authors.affiliation: Department of Thoracic Surgery, Mount Sinai Medical Center, New York, New York. Electronic address: raja.flores@mountsinai.org.
authors.forename: Raja M
authors.initials: RM
authors.lastname: Flores
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D020775:Thoracic Surgery, Video-Assisted
chemical_list: D007074:Immunoglobulin G