title: Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?
abstract: Ezrin, radixin and moesin, which are strongly expressed in the Schwann cell microvilli, are putative targets for autoantibodies in acute or chronic inflammatory demyelinating polyneuropathy (AIDP or CIDP). An association between anti-moesin IgG antibodies and cytomegalovirus-related AIDP has been postulated. None of 41 AIDP patients, including 8 cytomegalovirus-related AIDP patients, and 23 CIDP had IgG or IgM antibodies to ezrin, radixin and moesin; whereas, one patient with cytomegalovirus-related AIDP had anti-ezrin IgM antibodies. Ezrin, radixin and moesin are unlikely targets for autoantibodies in AIDP and CIDP, and the association of anti-moesin antibodies with cytomegalovirus-related AIDP was not confirmed.
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Miyaji
authors.affiliation: Division of Neurology, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
authors.forename: Nortina
authors.initials: N
authors.lastname: Shahrizaila
authors.affiliation: Department of Neurology, National Neuroscience Institute, Singapore.
authors.forename: Thirugnanam
authors.initials: T
authors.lastname: Umapathi
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: Yee-Cheun
authors.initials: YC
authors.lastname: Chan
authors.affiliation: Department of Neurology, Dokkyo Medical University, Tochigi, Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: mdcyuki@nus.edu.sg.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yuki
mesh_terms: D001323:Autoantibodies / Q000097:blood; D003598:Cytoskeletal Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008840:Microfilament Proteins / Q000235:genetics* / Q000378:metabolism; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000097:blood / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D000099149:Ezrin
chemical_list: D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008565:Membrane Proteins; D008840:Microfilament Proteins; D000099149:Ezrin; C071058:moesin; C071776:radixin
keywords: Acute inflammatory demyelinating polyneuropathies; Chronic inflammatory demyelinating polyneuropathies; Ezrin; Moesin; Radixin