title: [Certain toxicodynamic and toxicokinetic features of combined subchronic intoxication with hexavalent chromium and nickel].
abstract: Repeated intraperitoneal injections of nickel and chromium (VI) into rats appeared to demonstrate that the combined subchronic toxicity can be additive or vary (mostly to subadditivity) in accordance with effect on which they are evaluated. With moderate general toxic effects, the studied combination has marked genotoxicity with additive effect. The studies demonstrated reciprocal influence of nickel and chromium on accumulation of the second metal in some organs (especially, in spleen), but not on its renal excretion.
authors.forename: I A
authors.initials: IA
authors.lastname: Minigalieva
authors.forename: E P
authors.initials: EP
authors.lastname: Kireeva
authors.forename: E V
authors.initials: EV
authors.lastname: Grigor'eva
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002840:Chromates / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D053938:DNA Fragmentation / Q000187:drug effects; D004357:Drug Synergism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009532:Nickel / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D009928:Organ Specificity; D017680:Potassium Compounds / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D059550:Toxicity Tests, Subchronic
chemical_list: D002840:Chromates; D017680:Potassium Compounds; C027373:potassium chromate(VI); C022838:nickel chloride; D009532:Nickel