title: Endothelial lipase-384A/C polymorphism is associated with acute coronary syndrome and lipid status in elderly Uygur patients in Xinjiang.
abstract: OBJECTIVE
  To explore the relationship between the endothelial lipase (EL) gene promoter -384A/C polymorphism and acute coronary syndrome (ACS) and lipid status in elderly Uygur patients in Xinjiang.
  
  
  METHODS
  The polymerase chain reaction-restriction fragment length polymorphism method was used to detect the EL gene promoter -384A/C genotype in 341 cases of elderly patients with ACS and 380 healthy subjects.
  
  
  RESULTS
  In an elderly Chinese Han population, the EL-384A/C genotype and allele frequency distribution were significantly different between the ACS group and the control group (p<0.05); the frequency of the CC genotype in the ACS group was significantly higher than that in the control group (p<0.05). After adjusting for gender, age, diabetes, hypertension, smoking, hyperlipidemia, and other cardiovascular risk factors, the difference remains statistically significant (p<0.05). In the ACS group, C allele carriers had significantly higher serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol concentrations compared to AA genotypes (all p<0.05).
  
  
  CONCLUSIONS
  EL-384A/C polymorphism was significantly associated with the ACS and lipids profile in an elderly Uygur population in Xinjiang.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University , Xinjiang, People's Republic of China .
authors.forename: Ding
authors.initials: D
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000208:ethnology; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D014280:Triglycerides / Q000097:blood*
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides; C410382:LIPG protein, human; D008049:Lipase