title: Framing expectations in early HIV cure research.
abstract: Language used to describe clinical research represents a powerful opportunity to educate volunteers. In the case of HIV cure research there is an emerging need to manage expectations by using the term 'experiment'. Cure experiments are proof-of-concept studies designed to evaluate novel paradigms to reduce persistent HIV-1 reservoirs, without any expectation of medical benefit.
authors.affiliation: Collaboratory of AIDS Researchers for Eradication (CARE), Institute for Global Health and Infectious Diseases (IGHID), The University of North Carolina at Chapel Hill, 120 Mason Farm Road, 2060 Genetic Medicine Building CB 7042, Chapel Hill, NC 27599-7042, USA.
authors.forename: Karine
authors.initials: K
authors.lastname: Dubé
authors.affiliation: Department of Social Medicine, School of Medicine, The University of North Carolina at Chapel Hill, 347A MacNider, Campus Box 7240, Chapel Hill, NC 27599-7240, USA.
authors.forename: Gail E
authors.initials: GE
authors.lastname: Henderson
authors.affiliation: Collaboratory of AIDS Researchers for Eradication (CARE), Institute for Global Health and Infectious Diseases (IGHID), The University of North Carolina at Chapel Hill, 120 Mason Farm Road, 2060 Genetic Medicine Building CB 7042, Chapel Hill, NC 27599-7042, USA. Electronic address: dmargo@med.unc.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Margolis
mesh_terms: D035843:Biomedical Research; D015658:HIV Infections / Q000628:therapy* / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans
keywords: HIV cure research; expectations; experiments; trials