title: Pyoderma Gangrenosum among Patients with Inflammatory Bowel Disease: A Descriptive Cohort Study.
abstract: BACKGROUND
  Pyoderma gangrenosum (PG) is a severe extraintestinal manifestation of inflammatory bowel disease (IBD).
  
  
  OBJECTIVE
  To better characterize PG features and management among an IBD cohort.
  
  
  METHODS
  Subjects with PG were identified using a large database at a tertiary center. Patient demographics and clinical characteristics were summarized using descriptive statistics.
  
  
  RESULTS
  Eighty patients with an episode(s) of PG were identified, yielding an overall prevalence of 1.9%. Overall, 93% of patients with PG had some degree of colonic inflammation. Thirty-one (39%) patients required hospitalization for PG. Underlying bowel disease was active at the time of PG episode(s) in 52 (65%) patients. The PG location was variable, with the lower extremity being the most common. Most patients (71.3%) required multiple therapies to achieve PG healing.
  
  
  CONCLUSIONS
  We describe one of the largest case series of PG among patients with IBD. The variety of treatment strategies used highlights the lack of clear guidelines in managing this complex group of patients.
authors.forename: Adam V
authors.initials: AV
authors.lastname: Weizman
authors.forename: Brian
authors.initials: B
authors.lastname: Huang
authors.forename: Stephan
authors.initials: S
authors.lastname: Targan
authors.forename: Marla
authors.initials: M
authors.lastname: Dubinsky
authors.forename: Phillip
authors.initials: P
authors.lastname: Fleshner
authors.forename: Manreet
authors.initials: M
authors.lastname: Kaur
authors.forename: Andrew
authors.initials: A
authors.lastname: Ippoliti
authors.forename: Deepa
authors.initials: D
authors.lastname: Panikkath
authors.forename: Eric
authors.initials: E
authors.lastname: Vasiliauskas
authors.forename: David
authors.initials: D
authors.lastname: Shih
authors.forename: Dermot P B
authors.initials: DP
authors.lastname: McGovern
authors.forename: Gil Y
authors.initials: GY
authors.lastname: Melmed