title: Cyclization of η3-benzylpalladium intermediates derived from carbene insertion.
abstract: Migratory insertion of benzylidene carbene ligands into arylpalladium(II) species generates η(3)-benzylpalladium intermediates that can cyclize to generate five- and six-membered rings with new sp(3) centers. The reaction tolerates a range of arene functional groups and stabilized enolates. The products generated through this reaction are 1-arylindanes and 1-aryltetralins that are common to a range of natural products.
authors.affiliation: Department of Chemistry, University of California , 1102 Natural Sciences 2, Irvine, California 92697-2025, United States.
authors.forename: Eugene S
authors.initials: ES
authors.lastname: Gutman
authors.forename: Vanessa
authors.initials: V
authors.lastname: Arredondo
authors.forename: David L
authors.initials: DL
authors.lastname: Van Vranken
mesh_terms: D001688:Biological Products / Q000737:chemistry; D003500:Cyclization; D007189:Indans / Q000138:chemical synthesis* / Q000737:chemistry; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013764:Tetrahydronaphthalenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D007189:Indans; D013764:Tetrahydronaphthalenes; C030011:carbene; D010165:Palladium; D008697:Methane