title: Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter.
abstract: The multidrug resistance protein 1 (MRP1) encoded by ABCC1 was originally discovered as a cause of multidrug resistance in tumor cells. However, it is now clear that MRP1 serves a broader role than simply mediating the ATP-dependent efflux of drugs from cells. The antioxidant GSH and the pro-inflammatory cysteinyl leukotriene C4 have been identified as key physiological organic anions effluxed by MRP1, and an ever growing body of evidence indicates that additional lipid-derived mediators are also substrates of this transporter. As such, MRP1 is a multitasking transporter that likely influences the etiology and progression of a host of human diseases.
authors.affiliation: From the Department of Pathology and Molecular Medicine and Division of Cancer Biology and Genetics, Queen's University, Kingston, Ontario K7L 3N6, Canada spc.cole@queensu.ca.
authors.forename: Susan P C
authors.initials: SP
authors.lastname: Cole
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D000838:Anions; D000975:Antioxidants / Q000737:chemistry; D001692:Biological Transport; D045744:Cell Line, Tumor; D004967:Estrogens / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D007249:Inflammation; D017997:Leukotriene C4 / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D008246:Lysophospholipids / Q000737:chemistry; D051379:Mice; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism / Q000502:physiology*; D018384:Oxidative Stress; D010100:Oxygen / Q000737:chemistry; D015398:Signal Transduction; D015262:Xenobiotics / Q000737:chemistry
chemical_list: D000255:Adenosine Triphosphate; D000838:Anions; D000975:Antioxidants; D004967:Estrogens; D005978:Glutathione; D017997:Leukotriene C4; D008055:Lipids; D008246:Lysophospholipids; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010100:Oxygen; D015262:Xenobiotics; C421109:multidrug resistance-associated protein 1
keywords: ABC Transporter; Inflammation; Leukotriene; Lipid Signaling; Lipid Transport; Lysophospholipid; MRP1; Multidrug Transporter; Organic Anion Transport; Oxidative Stress