title: [Homeostatic model of aging: state and perspectives].
abstract: The homeostatic model of aging formalizing the concept of oxidative damage to the body was proposed in 2001. This formalization led to extensive opportunities for using the model to analyze reproduction and longevity of living organisms. Currently, the simulation of life processes in fruit flies gives much attention to the distribution of resources, taking into account the action of genetic noise. The result is arising of individual heterogeneity, in which unbalanced allocation of resources ends with the death from reproductive overload. The article considers the model of the mechanism of individual reproduction of stochasticity and possibility of its use to assess the maximally tolerated changes in the external environment.
authors.forename: V N
authors.initials: VN
authors.lastname: Novosel'tsev
authors.forename: Zh A
authors.initials: ZhA
authors.lastname: Novosel'tseva
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D004330:Drosophila; D059647:Gene-Environment Interaction; D018740:Genetic Heterogeneity; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000502:physiology; D008954:Models, Biological; D012098:Reproduction / Q000502:physiology; D013269:Stochastic Processes