title: Coronary and abdominal aorta calcification in rheumatoid arthritis: relationships with traditional cardiovascular risk factors, disease characteristics, and concomitant treatments.
abstract: OBJECTIVE
  To assess the influence of traditional cardiovascular (CV) risk factors, disease characteristics, and concomitant treatments in patients with rheumatoid arthritis (RA) on coronary artery calcification (CAC) and abdominal aorta calcification (AAC).
  
  
  METHODS
  In our cross-sectional study, 75 patients with RA were compared with 75 age-matched and sex-matched control participants. The CAC and AAC scores were measured by computed tomography in patients with no clinical evidence of coronary artery disease. The relationships between the presence or absence of CAC and AAC and traditional CV risk factors, disease characteristics, and concomitant treatments in patients with RA were assessed in a multiple logistic regression analysis.
  
  
  RESULTS
  The RA and control groups did not differ significantly in terms of age, sex composition, or the prevalence of traditional CV risk factors. AAC and CAC were more prevalent and severe in patients with RA than in controls. Older age (OR=1.15, p<0.01) and hypertension (OR=3.77, p=0.04) were found to be independently associated with CAC, whereas current use of methotrexate (MTX; OR=0.12, p=0.01) was found to be associated with the absence of CAC. Older age (OR per yr=1.17, p<0.001) and erosive arthritis (OR=3.78, p=0.03) were found to be independently associated with AAC.
  
  
  CONCLUSIONS
  Our study demonstrates that in patients with RA, (1) CAC and AAC are more prevalent and more severe compared with age-matched and sex-matched control participants, (2) current use of MTX is a major determinant of the absence of CAC, and (3) erosive arthritis is a major determinant of AAC.
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital. julienpaccou@yahoo.fr.
authors.forename: Julien
authors.initials: J
authors.lastname: Paccou
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Cédric
authors.initials: C
authors.lastname: Renard
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Sophie
authors.initials: S
authors.lastname: Liabeuf
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Said
authors.initials: S
authors.lastname: Kamel
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Patrice
authors.initials: P
authors.lastname: Fardellone
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Michel
authors.initials: M
authors.lastname: Brazier
authors.affiliation: From the Department of Rheumatology; INSERM U1088 (Pathophysiological mechanisms and consequences of cardiovascular calcification: role of cardiovascular and bone remodelling); Clinical Research Center, Division of Clinical Pharmacology; Department of Endocrine and Bone Biology, Amiens University Hospital, Amiens; Department of Nephrology, Amboise Paré University Hospital, Boulogne Billancourt, France.J. Paccou, MD, PhD; P. Fardellone, MD, PhD, Department of Rheumatology, INSERM U1088; C. Renard, MD; S. Kamel, PhD, INSERM U1088; S. Liabeuf, PharmD, PhD, INSERM U1088, Clinical Research Center, Division of Clinical Pharmacology, Amiens University Hospital; Z.A. Massy, MD, PhD, INSERM U1088, Amiens University Hospital, Department of Nephrology, Amboise Paré University Hospital; M. Brazier, MD, PharmD, PhD; R. Mentaverri, PharmD, PhD, INSERM U1088; Department of Endocrine and Bone Biology, Amiens University Hospital.
authors.forename: Romuald
authors.initials: R
authors.lastname: Mentaverri
mesh_terms: D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D001012:Aorta, Abdominal / Q000473:pathology*; D001018:Aortic Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy; D001027:Aortography / Q000379:methods; D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D015897:Comorbidity; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D018709:Statistics, Nonparametric; D061205:Vascular Calcification / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology
keywords: ABDOMINAL AORTA CALCIFICATION; CORONARY ARTERY CALCIFICATION; EROSIVE ARTHRITIS; METHOTREXATE; RHEUMATOID ARTHRITIS; TRADITIONAL CARDIOVASCULAR RISK FACTOR