title: Local control of giant cell tumors of the long bone after aggressive curettage with and without bone cement.
abstract: BACKGROUND
  Aggressive curettage has been well established for the treatment of giant cell tumors (GCTs) of the bone. The purpose of this study was to review our experience and evaluate the role of different implant materials in patients with GCTs of the extremities after aggressive curettage.
  
  
  METHODS
  A total of 119 patients with GCTs of the long bone were treated at the First Affiliated Hospital of Sun Yat-Sen University between 2004 and 2009. We excluded patients presenting metastases, recurrent tumors, and soft tissue involvement and those with Jaffe pathological grade III. The remaining 65 patients were treated with aggressive curettage using a bone graft or bone cement to fill the cavity. The recurrence rates and functional scores associated with the different fillings were analyzed.
  
  
  RESULTS
  Aggressive curettage and bone grafting was performed in 34 cases (52.3%), and aggressive curettage with bone cement was performed in 31 cases (47.7%). The overall recurrence rate after the aggressive intralesional procedures was 35.3% with bone grafting and 12.9% when bone cement was used as an adjuvant filling. The recurrence rate following aggressive curettage and bone grafting was higher than that following aggressive curettage with cement (p = 0.038). The Musculoskeletal Tumor Society (MSTS) score for bone graft patients was 91.1%, which was significantly lower than that for patients treated with bone cement (94.7%).
  
  
  CONCLUSIONS
  The use of bone cement was associated with a significantly lower recurrence rate than bone grafting following aggressive intralesional curettage to treat benign giant cell tumors of the long bone. Better MSTS functional results were also observed in the bone cement group compared to the bone graft group.
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Gao
authors.forename: Jun-qiang
authors.initials: JQ
authors.lastname: Yin
authors.forename: Xian-biao
authors.initials: XB
authors.lastname: Xie
authors.forename: Chang-ye
authors.initials: CY
authors.lastname: Zou
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Orthopaedics, First Affiliated Hospital of Sun Yat-Sen University, 58# zhongshan 2 road, Guangzhou 510080, P,R, China. shenjingnan@126.com.
authors.forename: Jing-nan
authors.initials: JN
authors.lastname: Shen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D003475:Curettage / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013977:Tibia / Q000000981:diagnostic imaging / Q000601:surgery*; D055815:Young Adult
chemical_list: D001843:Bone Cements