title: Isolated nodular thymic amyloidosis associated with diplopia.
abstract: An 85-year-old man presented with diplopia and anterior mediastinal tumor that had enlarged during the preceding 4-year period. Computed tomographic chest imaging showed an irregularly shaped mass comprising two nodules (diameter, 4 cm) with calcification. Suspecting thymoma, we performed video-assisted thoracoscopic thymectomy. The resected specimen showed deposition of homogeneous eosinophilic and hyalinized material around the vessel wall in thymic tissue, and it stained positively for anti-λ antibody, indicating localized AL amyloidosis. There was no other organ dysfunction or symptoms and no evidence of systemic amyloidosis. Diplopia resolved immediately after thymectomy; however, the connection of diplopia with amyloidoma and thymic tissue remains uncertain.
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Fumitomo
authors.initials: F
authors.lastname: Sato
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan. Electronic address: yoshinobuhata@hotmail.com.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Hata
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Otsuka
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Makino
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Koezuka
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Shuich
authors.initials: S
authors.lastname: Sasamoto
authors.affiliation: Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Wakayama
authors.affiliation: Department of Surgical Pathology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
authors.affiliation: Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Nagano, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sekijima
authors.affiliation: Division of Chest Surgery, Toho University School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iyoda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000150:complications* / Q000601:surgery; D004172:Diplopia / Q000209:etiology*; D006801:Humans; D008206:Lymphatic Diseases / Q000150:complications* / Q000601:surgery; D008297:Male; D008479:Mediastinal Neoplasms / Q000601:surgery; D020775:Thoracic Surgery, Video-Assisted; D013950:Thymus Gland / Q000473:pathology*