title: A 5-year survey of antimicrobial susceptibility profiles of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with bloodstream infections in Northeast Italy.
abstract: A 5-year survey (2009-2013) of antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) isolated from patients with bloodstream infections was carried out in Northeast Italy. No upward creep of glycopeptides MICs was documented among 582 nonduplicate MRSA blood isolates, which were tested in accordance with broth microdilution and interpreted in accordance with EUCAST recommendations. Teicoplanin showed stably a lower MIC50 in comparison with vancomycin (0.25-0.5 versus 1 mg/L). The activities of newer anti-MRSA antibacterials stratified by glycopeptides MICs showed similar trends in MICs of either vancomycin or teicoplanin with those of daptomycin, linezolid, and tigecycline. We hypothesize that in centers with different distribution of glycopeptides MICs, downward for teicoplanin and upward for vancomycin, teicoplanin could be a more effective alternative to vancomycin for empirical treatment of MRSA-related bacteremia.
authors.affiliation: Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy; Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Cojutti
authors.affiliation: Laboratory of Clinical Microbiology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Scarparo
authors.affiliation: Laboratory of Clinical Microbiology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy.
authors.forename: Assunta
authors.initials: A
authors.lastname: Sartor
authors.affiliation: Institute of Microbiology, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Coato
authors.affiliation: Institute of Microbiology, Ca' Foncello Hospital, Treviso, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Rigoli
authors.affiliation: Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Udine, Italy; Department of Experimental and Clinical Medical Sciences, University of Udine, Udine, Italy. Electronic address: pea.federico@aoud.sanita.fvg.it.
authors.forename: Federico
authors.initials: F
authors.lastname: Pea
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001769:Blood / Q000382:microbiology; D017576:Daptomycin / Q000494:pharmacology; D006306:Health Surveys; D006801:Humans; D007558:Italy; D000069349:Linezolid; D008137:Longitudinal Studies; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives / Q000494:pharmacology; D023303:Oxazolidinones / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000382:microbiology*; D017334:Teicoplanin / Q000494:pharmacology; D000078304:Tigecycline; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D017334:Teicoplanin; D014640:Vancomycin; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid; D017576:Daptomycin
keywords: Bacteraemia; Daptomycin; Glycopeptides; MRSA; Tigecycline