title: Carbapenemase-producing Klebsiella pneumoniae: molecular and genetic decoding.
abstract: Klebsiella pneumoniae carbapenemases (KPCs) were first identified in 1996 in the USA. Since then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and have spread internationally. Dissemination of blaKPC involves both horizontal transfer of blaKPC genes and plasmids, and clonal spread. Of epidemiological significance, the international spread of KPC-producing K. pneumoniae is primarily associated with a single multilocus sequence type (ST), ST258, and its related variants. However, the molecular factors contributing to the success of ST258 largely remain unclear. In this review, we discuss the recent progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of plasmid and genome composition and structure among the KPC epidemic clone, and we identify possible factors that influence its epidemiological success.
authors.affiliation: Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.affiliation: Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
authors.forename: Barun
authors.initials: B
authors.lastname: Mathema
authors.affiliation: Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
authors.forename: Kalyan D
authors.initials: KD
authors.lastname: Chavda
authors.affiliation: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
authors.forename: Frank R
authors.initials: FR
authors.lastname: DeLeo
authors.affiliation: Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA; Departments of Medicine, Pharmacology, Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
authors.affiliation: Public Research Institute TB Center, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA. Electronic address: kreiswba@njms.rutgers.edu.
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D023281:Genomics; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D058885:Multilocus Sequence Typing; D010957:Plasmids; D001618:beta-Lactamases / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; D004251:DNA Transposable Elements; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Klebsiella pneumoniae carbapenemase; ST258; carbapenem-resistant