title: Altered sphingoid base profiles in type 1 compared to type 2 diabetes.
abstract: BACKGROUND
  Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated.
  
  
  RESULTS
  We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N = 27), T2DM (N = 30) and healthy controls (N = 23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM.
  
  
  CONCLUSIONS
  Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels.
authors.forename: Nancy
authors.initials: N
authors.lastname: Wei
authors.forename: Jessica
authors.initials: J
authors.lastname: Pan
authors.forename: Rodica
authors.initials: R
authors.lastname: Pop-Busui
authors.forename: Alaa
authors.initials: A
authors.lastname: Othman
authors.forename: Irina
authors.initials: I
authors.lastname: Alecu
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hornemann
authors.affiliation: MGH Neuroscience Center, Department of Neurology, Harvard Medical School, 55 Fruit Street ACC 708, Boston, MA 02114, USA. feichler@partners.org.
authors.forename: Florian S
authors.initials: FS
authors.lastname: Eichler
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D008055:Lipids; D008297:Male; D008875:Middle Aged; D013107:Sphingolipids / Q000097:blood; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D008055:Lipids; D013107:Sphingolipids; D013110:Sphingosine; C408363:spisulosine