title: Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies.
abstract: Glutathione S-transferase Omega (GSTO) plays an important role in the development of cancer. Recently, a number of studies have investigated the association between single nucleotide polymorphisms on GSTO and susceptibility to cancer; however, the results remain inconclusive. We performed a meta-analysis of 20 studies, involving 4770 cases and 5701 controls to identify the strength of association by pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs). Overall, the pooled results revealed a significantly increased risk of susceptibility for GSTO2 polymorphism (GG vs. AA: OR = 1.20, 95%CI: 1.02-1.41, Pheterogeneity = 0.116), but no significant association was found for GSTO1 polymorphism. Subgroup analysis showed that GSTO2 polymorphism significantly increased cancer risk in Caucasian population (GG vs. AA: OR = 1.32, 95%CI 1.06-1.64, Pheterogeneity = 0.616) and GSTO2 polymorphism was significantly associated with elevated risk of breast cancer (GG vs. AA OR = 1.37, 95%CI: 1.06-1.77; Pheterogeneity = 0.281). This meta-analysis demonstrates that GSTO2 polymorphism may significantly increase cancer risk in Caucasian population and is associated with elevated risk of breast cancer; while GSTO1 polymorphism is not associated with cancer risk.
authors.affiliation: 1] Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009 [2] The First Clinical College of Nanjing Medical University, Nanjing. 210000, China [3].
authors.forename: You-Tao
authors.initials: YT
authors.lastname: Xu
authors.affiliation: 1] Department of Hematology and Oncology, Jiangsu Province Geriatric Institute, No. 30 Luojia Road, Nanjing 210029, China [2].
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: 1] Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009 [2].
authors.forename: Rong
authors.initials: R
authors.lastname: Yin
authors.affiliation: 1] Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009 [2] The Fourth Clinical College of Nanjing Medical University, Nanjing 210000, China.
authors.forename: Man-Tang
authors.initials: MT
authors.lastname: Qiu
authors.affiliation: 1] The Fourth Clinical College of Nanjing Medical University, Nanjing 210000, China [2] Department of Thoracic Surgery, Nanjing Jiangning Hospital, the Affiliated Jiangning Hospital of Nanjing Medical University, Gushan 162, Nanjing, P.R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Thoracic Surgery, Nanjing Medical University affiliated cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Baiziting 42, Nanjing, P.R. China. 210009.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C490476:GSTO1 protein, human; D005982:Glutathione Transferase