title: Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells.
abstract: Five phenyl compounds, vanillin (1), methyl trans-ferulate (2), trans-p-coumaric acid methyl ester (3), N-benzoyltryptamine (4), and N-(trans-cinnamoyl)tryptamine (5), were isolated from the roots of Oryza sativa L. and identified on the basis of spectroscopic data. Compounds 3 and 5 showed strong inhibition effect on melanin production in murine B16-F10 melanoma cells and tyrosinase activity. Also, the quantitative analysis of the compounds was carried out using LC/MS/MS experiment. Compounds 3 and 5 could be used as skin-whitening agents.
authors.affiliation: a Department of Oriental Medicine Biotechnology , Graduate School of Biotechnology, Kyung Hee University , Yongin 446-701 , Republic of Korea.
authors.forename: Jin-Gyeong
authors.initials: JG
authors.lastname: Cho
authors.forename: Jeongran
authors.initials: J
authors.lastname: Huh
authors.forename: Rak-Hun
authors.initials: RH
authors.lastname: Jeong
authors.forename: Byeong-Ju
authors.initials: BJ
authors.lastname: Cha
authors.forename: Sabina
authors.initials: S
authors.lastname: Shrestha
authors.forename: Dong-Geol
authors.initials: DG
authors.lastname: Lee
authors.forename: Hee-Cheol
authors.initials: HC
authors.lastname: Kang
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D003373:Coumaric Acids / Q000494:pharmacology*; D008543:Melanins / Q000037:antagonists & inhibitors*; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D011422:Propionates; D053719:Tandem Mass Spectrometry; D014363:Tryptamines / Q000494:pharmacology*
chemical_list: D003373:Coumaric Acids; D008543:Melanins; D010936:Plant Extracts; D011422:Propionates; D014363:Tryptamines; D014442:Monophenol Monooxygenase; C495469:p-coumaric acid
keywords: N-(trans-cinnamoyl)tryptamine; anti-melanogenic effect; phenyl compound; rice root; trans-p-coumaric acid methyl ester