title: Oxidant-antioxidant balance during on-pump coronary artery bypass grafting.
abstract: BACKGROUND
  The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG.
  
  
  METHODS
  Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes).
  
  
  RESULTS
  TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P = 0.045, P = 0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P = 0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r = 0.43, P = 0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P = 0.023, P = 0.048), whereas a significant difference was not found in group 1 (P = 0.601, P = 0.327).
  
  
  CONCLUSIONS
  Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Mentese
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Sakarya University, 54180 Sakarya, Turkey.
authors.forename: Orhan Veli
authors.initials: OV
authors.lastname: Dogan
authors.affiliation: Department of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Gumushane University, 29100 Gumushane, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Turan
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, Turkey.
authors.forename: Sefer
authors.initials: S
authors.lastname: Usta
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, Turkey.
authors.forename: Emre
authors.initials: E
authors.lastname: Dogan
authors.affiliation: Department of Emergency Medicine, Kanuni Training and Research Hospital, 61290 Trabzon, Turkey.
authors.forename: Seda Oztas
authors.initials: SO
authors.lastname: Mentese
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Demir
authors.affiliation: Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, Turkey.
authors.forename: Tanil
authors.initials: T
authors.lastname: Ozer
authors.affiliation: Department of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, Turkey.
authors.forename: Ahmet Cagri
authors.initials: AC
authors.lastname: Aykan
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002839:Chromans / Q000097:blood; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000097:blood* / Q000473:pathology / Q000601:surgery; D003331:Coronary Vessels / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants; D002839:Chromans; D016877:Oxidants; D006861:Hydrogen Peroxide; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid