title: [New classification and genetic background of inherited ichthyoses].
abstract: A new classification of inherited ichthyoses is presented based on clinical features, genetic background and pathophysiology. Ichthyoses are disorders of cornification and may be part of syndromes. Ichthyosis vulgaris, X-linked ichthyosis, autosomal recessive congenital ichthyosis and syndrome-related variants are described. Severe forms can be potentially life-threatening. Dry scaly skin can be disabling and time-consuming, as the patient needs topical therapy and sometimes also systemic retinoids. Treatment today is symptomatic, but hopefully new knowledge will lead to targeted therapies.
authors.affiliation: Hudafdeling I og Allergicentret, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C. E-mail: rikke.elkjaer.andersen@rsyd.dk.
authors.forename: Rikke Elkjær
authors.initials: RE
authors.lastname: Andersen
authors.forename: Jens Michael
authors.initials: JM
authors.lastname: Hertz
authors.forename: Anette
authors.initials: A
authors.lastname: Bygum
mesh_terms: D003879:Dermatologic Agents / Q000627:therapeutic use; D020022:Genetic Predisposition to Disease; D006801:Humans; D007057:Ichthyosis / Q000145:classification / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology
chemical_list: D003879:Dermatologic Agents