title: Computational model of visual hallucination in dementia with Lewy bodies.
abstract: Patients with dementia with Lewy bodies (DLB) frequently experience visual hallucination (VH), which has been aptly described as people seeing things that are not there. The distinctive character of VH in DLB necessitates a new theory of visual cognition. We have conducted a series of studies with the aim to understand the mechanism of this dysfunction of the cognitive system. We have proposed that if we view the disease from the internal mechanism of neurocognitive processes, and if also take into consideration recent experimental data on conduction abnormality, at least some of the symptoms can be understood within the framework of network (or disconnection) syndromes. This paper describes the problem from a computational aspect and tries to determine whether conduction disturbances in a computational model can in fact produce a "computational" hallucination under appropriate assumptions.
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan. Electronic address: tsukada@es.hokudai.ac.jp.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Tsukada
authors.affiliation: Department of Intelligent Systems, Kyoto Sangyo University, Kyoto 603-8555, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujii
authors.affiliation: Institute of Industrial Science, The University of Tokyo, Tokyo 153-8505, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Aihara
authors.affiliation: Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan; Research Center for Integrative Mathematics (RCIM), Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Tsuda
mesh_terms: D003071:Cognition; D003198:Computer Simulation; D006212:Hallucinations / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D020961:Lewy Body Disease / Q000503:physiopathology / Q000523:psychology*; D008960:Models, Psychological; D017397:Prefrontal Cortex / Q000503:physiopathology
keywords: Conduction disturbance; Dementia with Lewy bodies; Object identity; Scene gist; Top-down facilitation; Visual hallucination