title: Stem cell differentiation in the bone-marrow.
abstract: Even in the absence of antigenic challenge, the adult immune system is in a state of constant flux and each day receives large numbers of newly formed lymphocytes. The bone-marrow is vital to this continuous renewal, both in its regulation and because it is the direct source of B cells in normal animals and the indirect source of T cells, which are derived ultimately from stem cells that flow from the bone-marrow to the thymus. In this article, John Schrader outlines stem-cell differentiation in the bone-marrow from the viewpoint of an immunologist, dealing mainly with lymphopoiesis, but also with the role of lymphocytes in the regulation of the bone-marrow.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research Post Office, Royal Melbourne Hospital, Parkville, Victoria, 3050, Australia.
authors.forename: J W
authors.initials: JW
authors.lastname: Schrader