title: Imaging visceral adhesion to polymeric mesh using pneumoperitoneal-MRI in an experimental rat model.
abstract: BACKGROUND
  Intraperitoneal mesh implantation is often associated with formation of adhesion to the mesh. This experimental study examines the potential of minimally invasive pneumoperitoneal-MRI to assess these adhesions in a preclinical context.
  
  
  METHODS
  Uncoated polyethylene terephthalate meshes were placed intraperitoneally in rats, in regard to the caecum previously scraped to promote petechial bleeding and subsequent adhesions. Examinations were performed 2-weeks post mesh implantation using a rodent dedicated high field MRI. Respiratory-triggered T2-weighted images were acquired prior to and after intraperitoneal injection of ~8-10 mL gas to induce a mechanical stress on the abdominal wall.
  
  
  RESULTS
  Adhesions are occasionally seen in sham-operated rats as opposed to rats receiving polyethylene terephthalate meshes. On high-resolution images, meshes can be detected due to their characteristic net shape. However, evidence of adherence is only found if intraperitoneal gas injection is performed, when a ~1-cm elevation of the abdominal wall is observed. When adherence occurs between the mesh and the caecum, the latter remains in contact with the wall. Looser adherences between visceral tissue and meshes are also observed.
  
  
  CONCLUSIONS
  T2-weighted pneumoperitoneal-MRI is a powerful tool for assessing adherence after intraperitoneal mesh implantation. According to the mini-invasive procedure adopted here, this approach may allow a temporal follow-up of adherence fate.
authors.affiliation: PRIMEX-CIFAB, Université d'Angers, LUNAM Université, IRIS-IBS, CHU Angers, 4 rue Larrey, 49933, Angers Cedex 9, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Franconi
authors.forename: Jérome
authors.initials: J
authors.lastname: Roux
authors.forename: Céline
authors.initials: C
authors.lastname: Lefebvre-Lacoeuille
authors.forename: Laurent
authors.initials: L
authors.lastname: Lemaire
mesh_terms: D000818:Animals; D002429:Cecal Diseases / Q000209:etiology / Q000473:pathology*; D002432:Cecum / Q000601:surgery; D005260:Female; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010537:Peritoneum / Q000601:surgery*; D011028:Pneumoperitoneum, Artificial; D011093:Polyethylene Terephthalates; D011108:Polymers; D017207:Rats, Sprague-Dawley; D013526:Surgical Mesh / Q000009:adverse effects*; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology*
chemical_list: D011093:Polyethylene Terephthalates; D011108:Polymers