title: Changes in cellular and molecular components of peripheral blood in patients with generalized aggressive periodontitis.
abstract: OBJECTIVE
  The association between periodontitis and systemic health is evident; however, until recently, there has been a lack of scientific evidence to define the relationship between aggressive periodontitis and systemic conditions. The aim of the present study was to evaluate the changes in the white blood cell count and levels of serum proteins in patients with generalized aggressive periodontitis (GAP) and to compare it with periodontally-healthy controls.
  
  
  METHODS
  Patients with GAP (n = 60) and periodontally-healthy controls (n = 60) were recruited. Clinical parameters, including probing depth and clinical attachment level, were examined. Blood cell variables, including leukocyte, neutrophil, and lymphocyte counts, and serum protein parameters, including total protein, albumin (ALB), globulin (GLB), ALB/GLB (A/G) ratio, and C-reactive protein levels, were analyzed.
  
  
  RESULTS
  The results showed a statistically-significant increase in neutrophil numbers and serum GLB and C-reactive protein levels in patients with GAP compared to the controls (P < 0.001), whereas the ALB level and A/G ratio were significantly lower compared to the control group.
  
  
  CONCLUSIONS
  The results showed possible changes in the cellular and molecular components of peripheral blood in patients with GAP compared to periodontally-healthy controls. These changes might represent the contribution of periodontal infections to systemic inflammation in relatively young individuals.
authors.affiliation: Department of Periodontology and Implantology, A.M.E Society's Dental College and Hospital, Raichur, Karnataka, India.
authors.forename: Reetika
authors.initials: R
authors.lastname: Gaddale
authors.affiliation: Department of Periodontology, H.K.E Society's S.Nijalingappa Institute of Dental Sciences and Research, Gulbarga, Karnataka, India.
authors.forename: Jayashree A
authors.initials: JA
authors.lastname: Mudda
authors.affiliation: Department of Periodontology, Indira Gandhi Institute of Dental Sciences, Pondicherry, Tamil Nadu, India.
authors.forename: Ilangovan
authors.initials: I
authors.lastname: Karthikeyan
authors.affiliation: Department of Periodontology, H.K.E Society's S.Nijalingappa Institute of Dental Sciences and Research, Gulbarga, Karnataka, India.
authors.forename: Shrikar R
authors.initials: SR
authors.lastname: Desai
authors.affiliation: Department of Periodontology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Wanlesswadi, Sangli-Miraj Road, Sangli, Maharashtra, India.
authors.forename: Harshada
authors.initials: H
authors.lastname: Shinde
authors.affiliation: Department of Periodontology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Wanlesswadi, Sangli-Miraj Road, Sangli, Maharashtra, India.
authors.forename: Pavan
authors.initials: P
authors.lastname: Deshpande
mesh_terms: D010520:Aggressive Periodontitis / Q000097:blood*; D001772:Blood Cell Count; D001798:Blood Proteins; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D009504:Neutrophils; D012709:Serum Albumin
chemical_list: D001798:Blood Proteins; D012709:Serum Albumin; D002097:C-Reactive Protein
keywords: C-reactive protein; aggressive periodontitis; leukocyte; serum protein; white blood cell