title: [Two pediatric cases of anti-NMDA receptor antibody encephalitis].
abstract: Although less frequent than viral encephalitis, anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a frequent form of acute pediatric encephalitis. After a prodromal phase of flu-like symptoms, psychiatric symptoms predominate - agitation, anxiety, hallucinations - and can make correct diagnosis more difficult. Also noted are abnormal dyskinesia and dystonia-like movements, partial seizures, difficulties talking or memorizing, and autonomic manifestations. The presentation of two cases of anti-NMDAR encephalitis illustrates the symptoms of this disease. Although the CSF abnormalities are not highly specific of this disease, and MRI most often normal, EEG shows more specific signs. These observations enable us to discuss different treatment options and understand the progression of this disease.
authors.affiliation: Service de pédiatrie générale, centre hospitalier intercommunal de Poissy-Saint-Germain-en-Laye, 10, rue du Champ-Gaillard, 78300 Poissy, France.
authors.forename: M
authors.initials: M
authors.lastname: Ben Azoun
authors.affiliation: Service de neuropédiatrie, CHU de Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.
authors.forename: S
authors.initials: S
authors.lastname: Tatencloux
authors.affiliation: Service de neuropédiatrie, CHU de Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France.
authors.forename: K
authors.initials: K
authors.lastname: Deiva
authors.affiliation: Service de pédiatrie générale, centre hospitalier intercommunal de Poissy-Saint-Germain-en-Laye, 10, rue du Champ-Gaillard, 78300 Poissy, France. Electronic address: pblanc@chi-poissy-st-germain.fr.
authors.forename: P
authors.initials: P
authors.lastname: Blanc
mesh_terms: D060426:Anti-N-Methyl-D-Aspartate Receptor Encephalitis / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood*; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004636:Emergency Service, Hospital; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005260:Female; D005602:France; D006801:Humans; D007116:Immunization, Passive; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009460:Neurologic Examination; D011237:Predictive Value of Tests; D062706:Prodromal Symptoms; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D000069283:Rituximab
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate; D000069283:Rituximab; D008775:Methylprednisolone