title: Cervical pathology in cytology-negative/HPV-positive women: results from Lampang Cancer Hospital, Thailand.
abstract: BACKGROUND
  To evaluate the cervical pathology of cytology-negative/high-risk human papillomavirus (HR-HPV) positive-women.
  
  
  METHODS
  This study recruited 4,583 women aged 30-70 years who had undergone cervical screening by liquid-based cytology and HR-HPV test (14 HR-HPV types) at Lampang Cancer Hospital during October 2012 to July 2013. Colposcopy was carried out in all women.
  
  
  RESULTS
  One hundred and ninety-two (4.19%) women were found to be cytology-negative/HR-HPV-positive. However, 23 cases were excluded because of incomplete information, leaving 169 women for further analyses. Of these 169, 45 (26.6%) were infected with HPV 16/18 and 49 (29.0%) with multiple genotypes of HR-HPV. Nineteen of 169 (11.24%) women were found to have CIN 2-3. No women in the present study had AIS or invasive cervical lesions. Prevalence of CIN 2-3 among women infected with HPV 16/18 was 15.6% which was higher than the 9.68% in those with non-HPV 16/18 oncogenic types.
  
  
  CONCLUSIONS
  Overall, 11% of cytology-negative/HR-HPV-positive women had significant cervical lesions. Risk of harboring such lesions was substantially increased among those who were HPV 16/18 positive.
authors.affiliation: Lampang Cancer Hospital, Thailand E-mail : nokkannika@yahoo.com.
authors.forename: Kannika
authors.initials: K
authors.lastname: Paengchit
authors.forename: Chumnan
authors.initials: C
authors.lastname: Kietpeerakool
authors.forename: Warunee
authors.initials: W
authors.lastname: Wangchai
authors.forename: Saifon
authors.initials: S
authors.lastname: Pouraeng
authors.forename: Somkiet
authors.initials: S
authors.lastname: Lalitwongsa
mesh_terms: D000328:Adult; D000368:Aged; D002173:Cancer Care Facilities; D003127:Colposcopy / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications* / Q000175:diagnosis; D011379:Prognosis; D013785:Thailand / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology / Q000821:virology