title: [Colonic morphological changes in experimental chronic colitis induced by dextran sulfate sodium].
abstract: OBJECTIVE
  To characterize morphological changes in the colonic wall in experimental chronic colitis induced by dextran sulfate sodium (DSS).
  
  
  METHODS
  Experiments were carried out on sexually mature male C57B1/6 mice. Drinking water in the animal dishes was replaced by 2% DSS solution for 6 days and the animals were taken away from the experiment on day 21 after initiation of DSS consumption. Hematoxylin- and eosin-stained colonic histological specimens were prepared by Masson's trichrome and Nissl methods.
  
  
  RESULTS
  Histologically, the colonic wall displayed epithelialized ulcers; mucosal remodeling; reductions in the count of goblet cells, crypts and their depth; mucosal inflammatory infiltration with lymphocytes, plasmocytes, and histiocytes; lymphoid tissue hyperplasia; diffuse and focal sclerosis of all colonic membranes; neuronal destructive changes in the myenteric and submucosal nerve plexuses.
  
  
  CONCLUSIONS
  The experimental model of DSS-induced chronic colitis corresponds to human colitis in morphological characteristics to a certain degree and may be used to study of the pathogenesis of this disease and to preclinically evaluate of the efficacy of medications.
authors.forename: N A
authors.initials: NA
authors.lastname: Zolotova
authors.forename: S O
authors.initials: SO
authors.lastname: Kiriukhin
authors.forename: D N
authors.initials: DN
authors.lastname: Khochansky
authors.forename: M T
authors.initials: MT
authors.lastname: Dobrynina
authors.forename: O V
authors.initials: OV
authors.lastname: Makarova
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003092:Colitis / Q000139:chemically induced* / Q000473:pathology*; D003106:Colon / Q000473:pathology*; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D051379:Mice
chemical_list: D016264:Dextran Sulfate