title: Interleukin-10 gene -1082 G/A polymorphism in cervical cancer and cervical intraepithelial neoplasia: meta-analysis.
abstract: OBJECTIVE
  To assess the association between polymorphism in the interleukin (IL)-10 promoter region of 1082 G/A and the risk of cervical cancer and/or cervical intraepithelial neoplasia (CIN), using meta-analysis.
  
  
  METHODS
  The electronic literature databases PubMed®, Embase®, Web of Science, CBMdisc and CNKI were searched for relevant studies. The strength of association between IL-10 gene -1082 G/A polymorphism and cervical cancer and/or CIN was measured using pooled odds ratios with 95% confidence intervals in four genetic models: allelic model (A allele versus G allele); additive model (A/A versus G/G); recessive model (A/A versus G/A+G/G); dominant model (A/A+G/A versus G/G).
  
  
  RESULTS
  Eight studies involving 1983 cases and 1618 controls were identified and included in the meta-analysis. No significant associations were found between IL-10 gene -1082 G/A polymorphism and cervical cancer and/or CIN in any of the genetic models.
  
  
  CONCLUSIONS
  IL-10 gene -1082 G/A polymorphism does not appear to be associated with the risk of cervical cancer and/or CIN.
authors.affiliation: Department of Obstetrics and Gynecology, Chinese PLA Air Force General Hospital, Beijing, China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Hepatobiliary Surgery Department, Chinese PLA Air Force General Hospital, Beijing, China.
authors.forename: Ya-Lin
authors.initials: YL
authors.lastname: Kong
authors.affiliation: Department of Obstetrics and Gynaecology, Chinese PLA General Hospital, Beijing, China.
authors.forename: Ya-Li
authors.initials: YL
authors.lastname: Li
authors.affiliation: Department of Emergency, Chinese PLA Air Force General Hospital, Beijing, China weiyyk@163.com.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Yin
mesh_terms: D044466:Asian People / Q000235:genetics; D044383:Black People / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics*; D044465:White People / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology / Q000235:genetics*
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Cervical cancer; cervical intraepithelial neoplasia; interleukin-10; meta-analysis; polymorphism