title: Celiac disease.
abstract: On the basis of strong evidence, gastrointestinal symptoms and failure to thrive are classic presentations of celiac disease, but atypical, nongastrointestinal symptoms are also extremely common, particularly in the older child and adolescent. (3)(4)(8). On the basis of some research evidence and consensus, guidelines recommend celiac testing in symptomatic children with typical and atypical symptoms and consideration of testing in those with associated conditions and first-degree relatives of those with celiac disease. (3)(9). On the basis of strong research evidence, measurement of tTG IgA and total serum IgA level has been reported to be the most cost-effective and accurate means of serologic testing for celiac disease and is the test of choice unless the child is younger than 2 years or IgA deficient. (9). On the basis of strong research evidence, children with elevated titers of celiac antibodies or strong clinical suspicion for celiac disease should be referred to a gastroenterologist for upper endoscopy and biopsy. Until this procedure is performed, the child should continue on a diet with ingestion of gluten. (3)(9). On the basis of strong research evidence, all those with a confirmed diagnosis of celiac disease should follow a strict gluten-free diet for life, with avoidance of all foods that contain wheat, barley, and rye ingredients. (3)(4). Referral to a health care professional with specialized knowledge of celiac disease and the gluten-free diet is critical because of the numerous ways, often hidden, in which gluten may be present in the diet and environment.
authors.affiliation: Department of Clinical Pediatrics, The Ohio State University College of Medicine, and Department of Gastroenterology, Hepatology, and Nutrition, Nationwide Children's Hospital, Columbus, OH.
authors.forename: Tracy R
authors.initials: TR
authors.lastname: Ediger
authors.affiliation: Department of Clinical Pediatrics, The Ohio State University College of Medicine, and Department of Gastroenterology, Nationwide Children's Hospital, Columbus, OH.
authors.forename: Ivor D
authors.initials: ID
authors.lastname: Hill
mesh_terms: D000906:Antibodies / Q000032:analysis; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis* / Q000178:diet therapy; D002648:Child; D055050:Diet, Gluten-Free; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D007422:Intestines / Q000473:pathology
chemical_list: D000906:Antibodies