title: Is tolerance the result of engaging surface Ig of B cells in cycle?
abstract: B-cell lymphomas, neonatal B cells and recently stimulated memory precursor B cells are all susceptible to tolerance induction. A property common to these cells is that they are all cycling. In this article, David Scott and Norman Klinman propose that tolerance is induced by the binding of a B cell's slg at a critical point in early G1 phase of the cell cycle. They make predictions from their hypothesis and invite suggestions for testing it.
authors.affiliation: Immunology Unit, University of Rochester Cancer Center, Rochester, New York 14642, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Scott
authors.affiliation: Department of Immunology, Scripps Clinic and Research Foundation, La Jolla, California 92037, USA.
authors.forename: N R
authors.initials: NR
authors.lastname: Klinman