title: Lipoic acid and lipoic acid analogs in cancer metabolism and chemotherapy.
abstract: The lipoic acid (lipoate) coenzyme is unique in all of mammalian metabolism. It is not only crucial to the function of some of the major enzymes feeding carbon into the tricarboxylic acid cycle, but also generates dynamic regulatory information about the metabolic status of the mitochondrial matrix, ultimately functioning to control these metabolic fluxes. Moreover, these lipoate-sensitive regulatory processes are apparently systematically redesigned in tumor cells and the affected enzymes commonly become especially central to cancer metabolism. Thus, lipoate-sensitive regulatory processes constitute potentially uniquely valuable targets for chemotherapeutic attack. Our goal here is to review the current status of our knowledge relevant to the use of lipoate and lipoate analogs to therapeutically attack malignant disease.
authors.affiliation: Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Bingham
authors.forename: Shawn D
authors.initials: SD
authors.lastname: Stuart
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Zachar
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002952:Citric Acid Cycle / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D008063:Thioctic Acid
keywords: cancer metabolism; chemotherapy; lipoate; lipoate analogs; lipoic acid; lipoic acid analogs; tumor mitochondria; two compartment metabolism