title: [Pulmonary zygomycosis in a diabetic child complicated with thrombus of the left atrial auricle].
abstract: Mucormycosis is a rare but fatal, opportunistic fungal infection caused by fungi of the order of mucorales in the class of Zygomycetes. Isolated pulmonary mucormycosis is rare and occurs principally in particular conditions, especially in patients with uncontrolled diabetes. The fungi invades the blood vessels and causes distal ischemic necrosis. We report a case in a 13-year-old girl with diabetes mellitus who developed pulmonary zygomycosis complicated with thrombus of the left atrial auricle. The diagnosis of mucormycosis was confirmed by histologic examination of endobronchial biopsies. Combined treatment with systemic amphotericin B and surgery resulted in a favorable outcome. This difficult diagnosis must be raised in diabetic patients with unresponsive lung infections in order to apply early aggressive therapy. Successful management continues to be early diagnosis, followed by systemic antifungal therapy and surgical resection combined with control of the underlying disease.
authors.affiliation: Service d'anatomie pathologique, hôpital A. Mami, Ariana, Tunisie. Electronic address: kaddour1fr@yahoo.fr.
authors.forename: A
authors.initials: A
authors.lastname: Ayadi-Kaddour
authors.affiliation: Service de pneumologie, pavillon B, hôpital A. Mami, Ariana, Tunisie.
authors.forename: J
authors.initials: J
authors.lastname: Ammar
authors.affiliation: Service d'anatomie pathologique, hôpital A. Mami, Ariana, Tunisie.
authors.forename: O
authors.initials: O
authors.lastname: Ismail
authors.affiliation: Service d'anatomie pathologique, hôpital A. Mami, Ariana, Tunisie.
authors.forename: E
authors.initials: E
authors.lastname: Braham
authors.affiliation: Service de pneumologie, pavillon B, hôpital A. Mami, Ariana, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Hamzaoui
authors.affiliation: Service de chirurgie thoracique, hôpital A. Mami, Ariana, Tunisie.
authors.forename: T
authors.initials: T
authors.lastname: Kilani
authors.affiliation: Service d'imagerie médicale, hôpital A. Mami, Ariana, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Zidi
authors.affiliation: Service d'anatomie pathologique, hôpital A. Mami, Ariana, Tunisie.
authors.forename: F
authors.initials: F
authors.lastname: El Mezni
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001999:Bronchoscopy; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006325:Heart Atria / Q000473:pathology; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D013927:Thrombosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014057:Tomography, X-Ray Computed; D020096:Zygomycosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy