title: Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale.
abstract: Two new bibenzyl derivatives, dendrocandin T (1) and dendrocandin U (2), together with eight known bibenzyls, were isolated from the stems of Dendrobium officinale. Those compounds were sent for the first time for central nervous system-related bioassay and the results indicated that compounds 3, 4, and 5 have a certain degree of neurite outgrowth-promoting activity, and compounds 1, 2, 6, and 7 also have weak activity. The results indicated that D. officinale used as health food and traditional Chinese medicine "Tiepi Shihu" has a health function of neurotrophic effects.
authors.affiliation: a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.
authors.forename: Liu
authors.initials: L
authors.lastname: Yang
authors.forename: Shou-Jin
authors.initials: SJ
authors.lastname: Liu
authors.forename: Huai-Rong
authors.initials: HR
authors.lastname: Luo
authors.forename: Juan
authors.initials: J
authors.lastname: Cui
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Xuan-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
mesh_terms: D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects; D031667:Dendrobium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D016501:Neurites / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry
chemical_list: D001632:Bibenzyls; D004365:Drugs, Chinese Herbal; C000598552:dendrocandin T; C000598553:dendrocandin U
keywords: Dendrobium officinale; bibenzyl; dendrocandin T; dendrocandin U; neurite outgrowth-promoting activity