title: Acknowledged signatures of matrix metalloproteinases in Takayasu's arteritis.
abstract: Takayasu's arteritis (TA) was reported as an eye disease in the year 1905 and later was confirmed as a vasculitis. Since then, the etiology of the disease remains unknown; however, characteristic clinical features suggest multiple causative factors. Recent progress in vascular biology and other disciplines enlightens the pathophysiology of TA and demonstrated induction of various nonspecific inflammatory symptoms and destruction of the arterial wall, which leads to aneurysms and rupture of the affected arteries. Matrix metalloproteinases (MMPs) as an enzyme family have well-established roles in several vascular pathologies including intima formation, atherosclerosiss and aneurysms. MMPs have been proposed to be one of the molecules with a potential of having dual role in the course of TA, first as an active participant in pathophysiology and secondly as a diagnostic biomarker for TA disease. The desire to improve our understanding of the importance of MMPs and their endogenous inhibitors (TIMPs) in TA disease and for the development of therapeutic agents has inspired basic and clinical scientists for over a decade. In the present paper, we summarized the scientific rationale which highlights the signatures of matrix metalloproteinases and their endogenous inhibitors in pathophysiology as well as their being a potential candidate as biomarker for Takayasu's arteritis.
authors.affiliation: Department of Orthopedics, Wuhan General Hospital of Guangzhou Command, 627 Wuluo Road, Wuhan, Hubei 430070, China.
authors.forename: Gang
authors.identifier: 0000-0001-8393-5116
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160036, India ; Division of Molecular Oncology, Department of Internal Medicine, Washington University in St. Louis, St. Louis, MO 63110, USA.
authors.forename: Nitin
authors.identifier: 0000-0002-0907-6410
authors.initials: N
authors.lastname: Mahajan
authors.affiliation: Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160036, India.
authors.forename: Veena
authors.initials: V
authors.lastname: Dhawan
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism*; D013625:Takayasu Arteritis / Q000201:enzymology* / Q000503:physiopathology; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases