title: Global lung cancer risk from PAH exposure highly depends on emission sources and individual susceptibility.
abstract: The health impacts of polycyclic aromatic hydrocarbons (PAHs), the most concerning organic pollutants, depend not only on the locations and strengths of emission sources, but also on individual susceptibility. Moreover, trans-boundary transport makes them a global concern. In this study, a comprehensive analysis of the global health impacts of polycyclic aromatic hydrocarbons (PAHs) in ambient air is presented. Model resolution is critical in exposure modelling. Globally, incremental lifetime lung cancer risk (ILCR) induced by ambient PAH exposure is 3.1 × 10(-5). If the individual susceptibility was not taken into consideration, the overall risk would be underestimated by 55% and the proportion of highly vulnerable population would be underestimated by more than 90%. Emphasizing on individual susceptibility, our study provides an instrumental revision of current risk assessment methodology. In terms of lung cancer risk, the most important sources are combustion of biomass fuels (40%) and fossil fuels (14%) in the residential/commercial sector, coke (13%) and aluminium (12%) production, and motor vehicles (9%). PAHs can travel long distance globally especially within the Eurasian continent. Still, the risk is dominantly contributed by local.
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Huizhong
authors.initials: H
authors.lastname: Shen
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Tao
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Liu
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Han
authors.initials: H
authors.lastname: Chen
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Yuanchen
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Shu
authors.initials: S
authors.lastname: Su
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Lin
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Yinyin
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Bengang
authors.initials: B
authors.lastname: Li
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Xilong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
authors.forename: Wenxin
authors.initials: W
authors.lastname: Liu
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D004198:Disease Susceptibility; D004784:Environmental Monitoring; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000453:epidemiology* / Q000473:pathology; D008962:Models, Theoretical; D018986:Motor Vehicles; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D012307:Risk Factors
chemical_list: D000393:Air Pollutants; D011084:Polycyclic Aromatic Hydrocarbons