title: [Clinical features of atopic asthma and their relation to the T-regulatory cells and total immunoglobulin E].
abstract: Allergic diseases are among the most popular in the world. Scientific hypothesis formation and multifactorial pathogenesis of atopic asthma (AA) is constantly updated. Our purpose of this study was to investigate the relationship of humoral and cellular immunity with features clinical and anamnestic data in patients AA. Found that AA is genetically determined disorders, mainly transmitted through the maternal line, characterized polisensibilization, most of household allergens. AA is often associated with other allergic nosology (62.2%) and gastrointestinal diseases (44.4%). In the absence of clinical evidence of disease at CD4+/CD25+/Foxp3+, IgE and IL-4 in patients with AA is higher than in healthy individuals. When polyvalent allergy has been a significant increase in IgE (199.3 +/- 22.2) and IL-4 (79.2 +/- 16.5) and reduced expression of molecules CD4+/CD25+/Foxp3+ compared with sensitization to one or two allergens.
authors.forename: N V
authors.initials: NV
authors.lastname: Liakhovs'ka
authors.forename: N L
authors.initials: NL
authors.lastname: Kutsenko
authors.forename: M V
authors.initials: MV
authors.lastname: Mykytiuk
authors.forename: I P
authors.initials: IP
authors.lastname: Kaĭdashev
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000145:classification / Q000235:genetics / Q000276:immunology*; D001249:Asthma / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D015704:CD4 Antigens / Q000235:genetics / Q000276:immunology; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology; D005786:Gene Expression Regulation; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007073:Immunoglobulin E / Q000235:genetics / Q000276:immunology*; D053645:Interleukin-2 Receptor alpha Subunit / Q000235:genetics / Q000276:immunology; D015847:Interleukin-4 / Q000235:genetics / Q000276:immunology; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology*
chemical_list: D000485:Allergens; D015704:CD4 Antigens; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508017:IL2RA protein, human; C508598:IL4 protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D015847:Interleukin-4; D007073:Immunoglobulin E