title: Corticobasal syndrome: Five new things.
abstract: Corticobasal syndrome (CBS) is characterized by asymmetric involuntary movements including rigidity, tremor, dystonia, and myoclonus, and often associated with apraxia, cortical sensory deficits, and alien limb phenomena. Additionally, there are various nonmotor (cognitive and language) deficits. CBS is associated with several distinct histopathologies, including corticobasal degeneration, other forms of tau-related frontotemporal lobar degeneration such as progressive supranuclear palsy, and Alzheimer disease. Accurate antemortem diagnosis of underlying pathology in CBS is challenging, though certain clinical and imaging findings may be helpful. Five recent advances in the understanding of CBS are reviewed, including clinical and pathologic features, imaging and CSF biomarkers, the role of specific genes, and the concept of a spectrum of tauopathies.
authors.affiliation: Department of Neurology (LMC, MG, RGG), University of Pennsylvania, Philadelphia; Department of Neurology (TR), University of Chicago, IL; and Department of Internal Medicine and Pathology (JJR), American University of Beirut, Lebanon.
authors.forename: Lama M
authors.initials: LM
authors.lastname: Chahine
authors.affiliation: Department of Neurology (LMC, MG, RGG), University of Pennsylvania, Philadelphia; Department of Neurology (TR), University of Chicago, IL; and Department of Internal Medicine and Pathology (JJR), American University of Beirut, Lebanon.
authors.forename: Tanya
authors.initials: T
authors.lastname: Rebeiz
authors.affiliation: Department of Neurology (LMC, MG, RGG), University of Pennsylvania, Philadelphia; Department of Neurology (TR), University of Chicago, IL; and Department of Internal Medicine and Pathology (JJR), American University of Beirut, Lebanon.
authors.forename: Jean J
authors.initials: JJ
authors.lastname: Rebeiz
authors.affiliation: Department of Neurology (LMC, MG, RGG), University of Pennsylvania, Philadelphia; Department of Neurology (TR), University of Chicago, IL; and Department of Internal Medicine and Pathology (JJR), American University of Beirut, Lebanon.
authors.forename: Murray
authors.initials: M
authors.lastname: Grossman
authors.affiliation: Department of Neurology (LMC, MG, RGG), University of Pennsylvania, Philadelphia; Department of Neurology (TR), University of Chicago, IL; and Department of Internal Medicine and Pathology (JJR), American University of Beirut, Lebanon.
authors.forename: Rachel G
authors.initials: RG
authors.lastname: Gross