title: Which intravenous bronchodilators are being administered to children presenting with acute severe wheeze in the UK and Ireland?
abstract: During a prospective 10-week assessment period, 3238 children aged 1-16 years presented with acute wheeze to Paediatric Emergency Research in the UK and Ireland centres. 110 (3.3%) received intravenous bronchodilators. Intravenous magnesium sulfate (MgSO4) was used in 67 (60.9%), salbutamol in 61 (55.5%) and aminophylline in 52 (47.3%) of cases. In 35 cases (31.8%), two drugs were used together, and in 18 cases (16.4%), all three drugs were administered. When used sequentially the most common order was salbutamol, then MgSO4, then aminophylline. Overall, 30 different intravenous treatment regimens were used varying in drugs, dose, rate and duration.
authors.affiliation: Department of General Paediatrics, Children's Hospital for Wales, Cardiff, UK.
authors.forename: I
authors.initials: I
authors.lastname: Morris
authors.affiliation: Paediatric Emergency Department, Bristol Royal Hospital for Children, Bristol, UK Academic Department of Emergency Care, University of the West of England, Bristol, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Lyttle
authors.affiliation: Department of Emergency Medicine, Cork University Hospital, Cork, Ireland.
authors.forename: R
authors.initials: R
authors.lastname: O'Sullivan
authors.affiliation: Paediatric Emergency Department, Bristol Royal Hospital for Children, Bristol, UK.
authors.forename: N
authors.initials: N
authors.lastname: Sargant
authors.affiliation: Department of Paediatric Respiratory Medicine, Children's Hospital for Wales, Cardiff, UK.
authors.forename: I J M
authors.initials: IJ
authors.lastname: Doull
authors.affiliation: Department of General Paediatrics, Children's Hospital for Wales, Cardiff, UK Institute of Molecular and Experimental Medicine, Cardiff University, School of Medicine, Cardiff, UK.
authors.forename: C V E
authors.identifier: http://orcid.org/0000-0001-8181-875X
authors.initials: CV
authors.lastname: Powell
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage*; D000628:Aminophylline / Q000008:administration & dosage*; D001249:Asthma / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D007494:Ireland / Q000453:epidemiology; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D012135:Respiratory Sounds / Q000187:drug effects* / Q000209:etiology; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D001993:Bronchodilator Agents; D000628:Aminophylline; D008278:Magnesium Sulfate; D000420:Albuterol
keywords: Asthma; Asthma Guidelines; Asthma Pharmacology; Paediatric asthma