title: Determination of tetracycline hydrochloride by terahertz spectroscopy with PLSR model.
abstract: Antibiotic residues in agricultural and food products are of great concern to legislatures and consumers. Reliable techniques for rapid and sensitive detection of these residues are necessary to ensure food safety. In this study, tetracycline hydrochloride (TC-HCl) in powder and solution form was detected and quantified using terahertz (THz) spectroscopy. Partial least-squares regression (PLSR) was used to build calibration models. The results obtained in this study indicated that the PLSR model for powder samples was excellent and could be used for quality control. However, the PLSR model for solution samples was not robust and needed to be improved. Overall, THz spectroscopy combined with PLSR model had its potential for the rapid and non-destructive prediction of TC-HCl residue without sophisticated methods, although the accuracy was not high for solution samples which should be improved in future study.
authors.affiliation: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, PR China.
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Qin
authors.affiliation: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, PR China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Xie
authors.affiliation: College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, PR China. Electronic address: yingyb@zju.edu.cn.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Ying
mesh_terms: D000900:Anti-Bacterial Agents; D059022:Food Safety; D055068:Terahertz Spectroscopy / Q000379:methods*; D013752:Tetracycline / Q000032:analysis*
chemical_list: D000900:Anti-Bacterial Agents; D013752:Tetracycline
keywords: Partial least-squares regression; Quantitative detection; Terahertz spectroscopy; Tetracycline hydrochloride