title: Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling.
abstract: Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic differences. Pharmacogenomics is the study of genetic contributions to drug response variability in order to provide evidence for a tailored therapy in an individual patient. Several studies have investigated the pharmacogenomics of the adrenergic receptor system and its role in the context of the use of β-blockers in treating heart failure. In this review, we will focus on the most significant polymorphisms described in the literature involving adrenergic receptors and adrenergic receptor-related proteins, as well as genetic variations influencing β-blocker metabolism.
authors.affiliation: Department of Translational Medical Sciences, Federico II University, Naples, Italy.
authors.forename: Grazia Daniela
authors.initials: GD
authors.lastname: Femminella
authors.affiliation: Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy ; Division of Biomedical Sciences, St George's University of London, London, UK.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Barrese
authors.affiliation: Department of Translational Medical Sciences, Federico II University, Naples, Italy ; "Salvatore Maugeri" Foundation - IRCCS - Scientific Institute of Telese Terme, Telese Terme, Benevento, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Ferrara
authors.affiliation: "Salvatore Maugeri" Foundation - IRCCS - Scientific Institute of Telese Terme, Telese Terme, Benevento, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rengo
keywords: adrenergic system; functional recovery; polymorphisms; β-blockers