title: Suppression of IgE responses following inhalation of antigen A natural homeostatic mechanism which limits sensitization to aeroallergens.
abstract: Contract between immune cells and airborne antigens is limited in the upper respiratory tract (URT) by physical barriers such as mucous. But some antigen does penetrate the URT epithelium. In this article, Patrick Holt and Jon Sedgwick postulate the existence of back-up immune mechanisms which prevent sensitization to antigens which cross epithelial barriers.
authors.affiliation: Clinical Immunology Research Unit, Princess Margaret Hospital, Subiaco 6008, Western Australia.
authors.forename: P G
authors.initials: PG
authors.lastname: Holt
authors.affiliation: MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, Oxford OX1 3RE, UK.
authors.forename: J D
authors.initials: JD
authors.lastname: Sedgwick