title: A bovine G8P[1] group A rotavirus isolated from an asymptomatically infected dog.
abstract: Group A rotaviruses (RVAs) are enteric pathogens with well-documented zoonotic transmissions to humans. The segmented genome of the virus enables reassortment events which might alter host susceptibility and/or disease course. Genetic analysis of rotavirus in dogs has so far only revealed RVAs with the VP7 and VP4 genome constellation G3P[3]. RVA G3P[3] have also been found in cats, humans, monkeys and bats. In the present study, we described an unusual RVA of genotype G8P[1] which was isolated from an asymptomatically infected young dog. The dog did not show signs of diarrhoea. Analysis of full-length segments of VP2, VP6 and VP7 as well as NSP1-NSP5 revealed a typical bovine-like genotype constellation G8-P[1]-I2-Rx-C2-Mx-A3-N2-T6-E2-H3. Phylogenetic analysis supported the hypothesis of an interspecies transmission from a bovine/artiodactyl species or from humans to the young dog. The isolate was likely to represent a multiple reassortant virus.
authors.affiliation: Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Sieg
authors.affiliation: Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Rückner
authors.affiliation: Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Köhler
authors.affiliation: Department of Small Animal Medicine, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Iwan
authors.initials: I
authors.lastname: Burgener
authors.affiliation: Institute of Virology, Faculty of Veterinary Medicine, University of Leipzig, Germany.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Vahlenkamp
mesh_terms: D000818:Animals; D002417:Cattle; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D016679:Genome, Viral / Q000235:genetics*; D005838:Genotype; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000235:genetics*; D012400:Rotavirus Infections / Q000821:virology*
chemical_list: D012367:RNA, Viral