title: Reprint of "Learning to breathe? Feedforward regulation of the inspiratory motor drive".
abstract: Claims have been made that breathing is in part controlled by feedforward regulation. In a classical conditioning paradigm, we investigated anticipatory increases in the inspiratory motor drive as measured by inspiratory occlusion pressure (P100). In an acquisition phase, an experimental group (N = 13) received a low-intensity resistive load (5 cmH2O/l/s) for three consecutive inspirations as Conditioned Stimulus (CS), preceding a load of a stronger intensity (20 cmH2O/l/s) for three subsequent inspirations as unconditioned stimulus (US). The control group (N = 11) received the low-intensity load for six consecutive inspirations. In a post-acquisition phase both groups received the low-intensity load for six consecutive inspirations. Responses to the CS-load only differed between groups during the first acquisition trials and a strong increase in P100 during the US-loads was observed, which habituated across the experiment. Our results suggest that the disruption caused by adding low to moderate resistive loads to three consecutive inspirations results in a short-lasting anticipatory increase in inspiratory motor drive.
authors.affiliation: Research Group on Health Psychology University of Leuven, Tiensestraat 102, Box 3726, B-3000 Leuven, Belgium.
authors.forename: Jonas
authors.initials: J
authors.lastname: Zaman
authors.affiliation: Research Group on Health Psychology University of Leuven, Tiensestraat 102, Box 3726, B-3000 Leuven, Belgium.
authors.forename: Omer
authors.initials: O
authors.lastname: Van den Bergh
authors.affiliation: Research Group on Health Psychology University of Leuven, Tiensestraat 102, Box 3726, B-3000 Leuven, Belgium.
authors.forename: Stien
authors.initials: S
authors.lastname: Fannes
authors.affiliation: Research Group on Health Psychology University of Leuven, Tiensestraat 102, Box 3726, B-3000 Leuven, Belgium. Electronic address: Ilse.VanDiest@ppw.kuleuven.be.
authors.forename: Ilse
authors.initials: I
authors.lastname: Van Diest
keywords: Inspiratory drive; Interoceptive conditioning; Occlusion pressure; Resistive loads; Respiratory learning