title: Hematological change parameters in patients with pressure ulcer at long-term care hospital.
abstract: OBJECTIVE
  To assess factors associated with the development of pressure ulcers, and to compare the effectiveness of pharmacological treatments.
  
  
  METHODS
  The factors associated with the development of pressure ulcers were compared in lesion-carrying patients (n=14) and non-carriers (n=16). Lesion-carrying patients were treated with 1% silver sulfadiazine or 0.6IU/g collagenase and were observed for 8 weeks. The data collected was analyzed with p<0.05 being statistically relevant.
  
  
  RESULTS
  The prevalence of pressure ulcers was about 6%. The comparison of carrier and non-carrier groups of pressure ulcers revealed no statistically significant difference in its occurrence with respect to age, sex, skin color, mobility, or the use of diapers. However, levels of hemoglobin, hematocrit, and red blood cells were found to be statistically different between groups, being lower in lesion-carrying patients. There was no significant difference found in lesion area between patients treated with collagenase or silver sulfadiazine, although both groups showed an overall reduction in lesion area through the treatment course.
  
  
  CONCLUSIONS
  Hematologic parameters showed a statistically significant difference between the two groups. Regarding the treatment of ulcers, there was no difference in the area of the lesion found between the groups treated with collagenase and silver sulfadiazine.
authors.affiliation: Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors.forename: Giselle Protta
authors.initials: GP
authors.lastname: Neiva
authors.affiliation: Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors.forename: Julia Romualdo
authors.initials: JR
authors.lastname: Carnevalli
authors.affiliation: Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors.forename: Rodrigo Lessa
authors.initials: RL
authors.lastname: Cataldi
authors.affiliation: Prefeitura Municipal de Juiz de Fora, Juiz de Fora, MG, Brazil.
authors.forename: Denise Mendes
authors.initials: DM
authors.lastname: Furtado
authors.affiliation: Universidade Federal de Juiz de Fora, Governador Valadares, MG, Brazil.
authors.forename: Rodrigo Luiz
authors.initials: RL
authors.lastname: Fabri
authors.affiliation: Universidade Federal de Juiz de Fora, Governador Valadares, MG, Brazil.
authors.forename: Pâmela Souza
authors.initials: PS
authors.lastname: Silva
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D017364:Collagenases / Q000627:therapeutic use*; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007902:Length of Stay; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D003668:Pressure Ulcer / Q000097:blood* / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D012307:Risk Factors; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D006454:Hemoglobins; D017364:Collagenases; D012837:Silver Sulfadiazine