title: FDG PET findings of the brain in sudden blindness caused by bilateral central retinal artery occlusion revealing giant cell arteritis.
abstract: We report the case of a 73-year-old woman presenting sudden blindness caused by bilateral simultaneous central retinal artery occlusion revealed by ophthalmoscopy. Temporal artery biopsy confirmed the giant cell arteritis. The patient was treated with a systemic steroid without visual recovery. FDG PET/CT was performed 6 months later in the context of persistent inflammatory syndrome. This case shows the close relationship between functional activity and glucose energy metabolism. We observed both bilateral occipital hypometabolism corresponding to loss of functional activity and bilateral temporal (auditory areas) and orbitofrontal hypermetabolism related to compensatory neuronal plasticity.
authors.affiliation: From the *Service de Biophysique et Médecine Nucléaire, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg; †ICube, Université de Strasbourg/CNRS UMR 7357; and ‡Fédération de Médecine Translationnelle de Strasbourg-Faculté de Médecine, Strasbourg, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Dietemann
authors.forename: Vincent
authors.initials: V
authors.lastname: Noblet
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
authors.forename: Cyrille
authors.initials: C
authors.lastname: Blondet
authors.forename: Izzie Jacques
authors.initials: IJ
authors.lastname: Namer
mesh_terms: D000368:Aged; D001766:Blindness / Q000000981:diagnostic imaging / Q000209:etiology*; D001921:Brain / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D013700:Giant Cell Arteritis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015356:Retinal Artery Occlusion / Q000150:complications* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18