title: Multifocal central nervous system hemangioblastoma: a case report and review of the literature.
abstract: An effective therapy for multifocal central nervous system hemangioblastoma (CNS HB) is needed. Here, we report a case of multifocal CNS HB. A 43-year-old man was diagnosed with CNS HB by enhanced computed tomography and magnetic resonance imaging. Six solid tumors and one cystic nodule were detected in his cerebellum. The patient underwent three surgeries followed by knife radiosurgery and had regular visits after the operation. In addition, histological observation with hematoxylin and eosin staining and immunohistochemistry for α-inhibin, Ki67, and vascular endothelial growth factor further provided evidence of cerebral HB. The symptoms of the patient were prominently improved after each operation, suggesting that multiple surgeries and radiation therapy are needed to prevent the proliferation and relapse of multifocal CNS HB. In addition, long-term, regular hospital visits were useful. Furthermore, genetic diagnosis and gene-targeted therapy might be a promising strategy against familial CNS HB in the future.
authors.affiliation: Department of Pathology, Guiyang Medical University, Guiyang, China.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Chu
authors.affiliation: Department of Pathology, Guiyang Medical University, Guiyang, China zhizhongguan@yahoo.com.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Guan
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Molecular Biology, Guiyang Medical University, Guiyang, China.
authors.forename: X L
authors.initials: XL
authors.lastname: Qi
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: M G
authors.initials: MG
authors.lastname: Dong
authors.affiliation: Department of Neurosurgery, The Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: Y M
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Department of Pathology, Guiyang Medical University, Guiyang, China.
authors.forename: Y N
authors.initials: YN
authors.lastname: Xiang
authors.affiliation: Department of Molecular Biology, Guiyang Medical University, Guiyang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
mesh_terms: D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed