title: Pollution and skin: from epidemiological and mechanistic studies to clinical implications.
abstract: In recent years, the health effects associated with air pollution have been intensively studied. Most studies focus on air pollution effects on the lung and the cardiovascular system. More recently, however, epidemiological and mechanistic studies suggest that air pollution is also affecting skin integrity. This state-of-the-art review focuses on this latter aspect; it was developed with the collaboration of European and Chinese board of experts with specific interests in environmental health, clinical and basic research in dermatology and cosmetic dermatology. A literature review limited to pollution and health effects and (sensitive) skin was performed using PubMed. Review and original articles were chosen. We summarize the existing scientific evidence that air pollution exerts detrimental effects on human skin, discuss potential clinical implications and suggest specific and unspecific cosmetic protective measures.
authors.affiliation: IUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; University of Düsseldorf, Medical Faculty, Deanery of Medicine, Germany. Electronic address: Jean.Krutmann@IUF-Duesseldorf.de.
authors.forename: Jean
authors.initials: J
authors.lastname: Krutmann
authors.affiliation: Department of Dermatology, The General Hospital of Air Force, Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Dermatology West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Peking University School of Public Health, No. 38 Xueyuan Road, Beijing 100191, China.
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Pan
authors.affiliation: L'Oréal Research and Innovation, Chevilly Larue, France.
authors.forename: Martha
authors.initials: M
authors.lastname: Crawford
authors.affiliation: L'Oréal Research and Innovation, Chevilly Larue, France.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Sore
authors.affiliation: La Roche-Posay Pharmaceutical Laboratories, Asnières, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Seite
mesh_terms: D000397:Air Pollution / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects; D014943:Global Health; D006801:Humans; D008954:Models, Biological; D010126:Ozone / Q000633:toxicity; D052638:Particulate Matter / Q000633:toxicity; D012307:Risk Factors; D012867:Skin / Q000187:drug effects / Q000293:injuries*
chemical_list: D052638:Particulate Matter; D010126:Ozone
keywords: Arylhydrocarbon receptor; Dermocosmetics; Ozone; Particulate matter; Sensitive skin; Skin aging