title: Antioxidant neolignan and phenolic glucosides from the fruit of Euterpe oleracea.
abstract: Three new glucosides, namely, (-)-7R8S-7',8'-dihydroxy-dihydrodehydroconiferyl alcohol-9-O-β-D-glucopyranoside (1), (+)-7S8R-7',8'-dihydroxy-dihydrodehydroconiferyl alcohol-9-O-β-D-glucopyranoside (2) and 4-hydroxy-2-methoxyphenyl 1-O-[6-(hydrogen 3-hydroxy-3-methylpentanedioate)]-β-D-glucopyranoside (3), along with 6 known compounds were isolated from the fruit of Euterpe oleracea Mart. Their structures were elucidated based on spectroscopic analyses including NMR, HR-ESI-MS and CD. All the isolated compounds demonstrated significant antioxidant activity and 2 displayed moderate cytotoxicity against HL-60 cells.
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Hu
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA.
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhao
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA.
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA.
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA.
authors.forename: Xing-Cong
authors.initials: XC
authors.lastname: Li
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Shui-han
authors.initials: SH
authors.lastname: Zhang
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Cai
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
authors.forename: Hui-yong
authors.initials: HY
authors.lastname: Huang
authors.affiliation: TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA. Electronic address: wangwei402@hotmail.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS, USA; Department of Pharmacognosy, School of Pharmacy, University of Mississippi, MS, USA; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Electronic address: ikhan@olemiss.edu.
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D065748:Euterpe / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D017705:Lignans / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry
chemical_list: D000975:Antioxidants; D005960:Glucosides; D017705:Lignans; D010636:Phenols
keywords: Antioxidant activity; Arecaceae; Açaí; Euterpe oleracea; Glucoside