title: [Characteristics of the spermatogenic epithelium in the testis of newborn rats--the offspring of female rats with chronic liver injury of various genesis].
abstract: The effect of chronic injury of hepatobiliary system of various genesis in females rats on the formation of spermatogenic epithelium in the testis of their newborn offspring was studied. The models of toxic (CCl4) and medicinal (tetracycline, paracetamol) liver injury were used. The state of the seminiferous epithelium was assessed on the serial histological sections of the testis with the use of the morphometric device. In experimental animals, a reduction of the diameter and the area of the seminiferous tubules (ST) was detected, associated with the decline of the total number of spermatogenic cells, spermatogonia of various generations, total number of spermatocytes and Sertoli cells. At the same time, in the newborn rats of all the experimental groups, the number of ST with the desquamated epithelium, and that one of the multinucleated spermatogenic cells with fragmented and pyknotic nuclei were increased.
authors.forename: M L
authors.initials: ML
authors.lastname: Sizonenko
authors.forename: G V
authors.initials: GV
authors.lastname: Briukhin
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000378:metabolism / Q000473:pathology; D005260:Female; D008099:Liver; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012670:Seminiferous Epithelium / Q000378:metabolism / Q000473:pathology; D013093:Spermatogonia / Q000378:metabolism / Q000473:pathology