title: High rate of detection of G8P[6] rotavirus in children with acute gastroenteritis in São Tomé and Príncipe.
abstract: The burden of rotavirus infections greatly affects the low-income African countries. In the absence of epidemiological data on pediatric diarrhea in São Tomé and Príncipe (STP), a study was conducted from August to December 2011. Rotavirus antigen was detected in 36.7 % of the collected fecal samples (87/237). G8P[6] was identified as the predominant genotype (71.1 % detection rate), while G1P[8] represented only 8.4 %. Phylogenetic analysis of VP7 G8 strains showed clustering within lineage G8d, while VP4 P[6] strains clustered within lineage 1a. Our results represent the first report on rotavirus from STP and show one of the highest detection rates of G8 rotaviruses worldwide.
authors.affiliation: Unidade de Microbiologia Médica, Grupo de Virologia, Centro de Malária e outras Doenças Tropicais, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008, Lisbon, Portugal, claudia.istrate@ihmt.unl.pt.
authors.forename: Claudia
authors.initials: C
authors.lastname: Istrate
authors.forename: Sumit
authors.initials: S
authors.lastname: Sharma
authors.forename: Johan
authors.initials: J
authors.lastname: Nordgren
authors.forename: Sandra
authors.initials: S
authors.lastname: Videira e Castro
authors.forename: Ângela
authors.initials: Â
authors.lastname: Lopes
authors.forename: João
authors.initials: J
authors.lastname: Piedade
authors.forename: Ahmed
authors.initials: A
authors.lastname: Zaky
authors.forename: António
authors.initials: A
authors.lastname: Lima
authors.forename: Edgar
authors.initials: E
authors.lastname: Neves
authors.forename: José
authors.initials: J
authors.lastname: Veiga
authors.forename: Aida
authors.initials: A
authors.lastname: Esteves
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000821:virology; D000956:Antigens, Viral / Q000235:genetics; D001266:Atlantic Islands / Q000453:epidemiology; D036022:Capsid Proteins / Q000235:genetics; D002675:Child, Preschool; D003967:Diarrhea / Q000821:virology; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology* / Q000821:virology*; D060005:Genotyping Techniques; D006801:Humans; D007223:Infant; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000821:virology*
chemical_list: D000956:Antigens, Viral; D036022:Capsid Proteins; D012367:RNA, Viral; C060339:VP4 protein, Rotavirus; C061332:VP6 protein, Rotavirus; C050779:VP7 protein, Rotavirus