title: A Randomized Clinical Trial Study: Anti-Oxidant, Anti-hyperglycemic and Anti-Hyperlipidemic Effects of Olibanum Gum in Type 2 Diabetic Patients.
abstract: Diabetes is a common metabolic disease in the world that has many adverse effects. Olibanum gum resin (from trees of the genus Boswellia) has traditionally been used in the treatment of various diseases such as diabetes. The aim of this study was the comparison of Olibanum gum resin effect with placebo on the treatment of type 2 diabetes. Inclusion criteria was diabetic patients with fasting blood sugar (FBS) =140-200 mg/dL. This study has been designed as double-blined clinical trial on 71 patients with type 2 diabetes and the patients randomly were divided to interventional and placebo groups. The patients on standard anti-diabetic therapy (metformin) treated with Olibanum gum resin (400 mg caps) and placebo tow times per day for 12 weeks, respectively. At the end of the twelfth week, the FBS, HbA1c, Insulin, total Cholesterol (Chol), LDL, Triglyceride (TG), HDL and other parameters were measured. The Olibanum gum resin lowered the FBS, HbA1c, Insulin, Chol, LDL and TG levels significantly (p < 0.001, p < 0.001, p <0.001, p = 0.003, p < 0.001 and p < 0.001, respectively) without any significant effects on the other blood lipid levels and liver/kidney function tests (p > 0.05) compared with the placebo at the endpoint. Moreover, this plant showed anti-oxidant effect and also no adverse effects were reported. The results suggest that Olibanum gum resin could be used as a safe anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic agent for type 2 diabetic patients.
authors.affiliation: Metabolic Disease Research Center, Department of Immunology, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Azadmehr
authors.affiliation: Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Amir
authors.initials: A
authors.lastname: Ziaee
authors.affiliation: Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
authors.forename: Laleh
authors.initials: L
authors.lastname: Ghanei
authors.affiliation: Pharmacology and Applied Medicine, Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Fallah Huseini
authors.affiliation: Pharmacognosy and Pharmaceutic Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Hajiaghaee
authors.affiliation: Department of Pharmacology, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Bahareh
authors.initials: B
authors.lastname: Tavakoli-Far
authors.affiliation: School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Kordafshari
keywords: Diabetes; Hyperglycemia; Hyperlipidemia; Olibanum gum resin; Patients