title: Association between single nucleotide polymorphisms in the ADD3 gene and susceptibility to biliary atresia.
abstract: OBJECTIVE
  Based on the results of previous studies, the ADD3 gene, located in the 10q24.2 region, may be a susceptibility gene of biliary atresia (BA). In this study, two single nucleotide polymorphisms (SNPs) in the ADD3 gene, rs17095355 C/T and rs10509906 G/C, were selected to investigate whether there is an association between these SNPs and susceptibility to BA in a Chinese population.
  
  
  METHODS
  A total of 752 Han Chinese (134 BA cases and 618 ethnically matched healthy controls) were included in the present study. The ADD3 gene polymorphisms were genotyped using a TaqMan genotyping assay.
  
  
  RESULTS
  Positive associations were found for the SNP rs17095355 in the codominant model; specifically, the frequencies of the CT and TT genotypes and the T allele were higher in the cases than the controls, demonstrating a significant risk for BA (odds ratio [OR] = 1.62, 95% confidence interval [CI] = 1.02-2.58; OR = 2.89, 95% CI = 1.72-4.86; and OR = 1.75, 95% CI = 1.34-2.29, respectively). Regarding rs10509906, the per-C-allele conferred an OR of 0.70 (95% CI = 0.49-1.00) under the additive model. A greater risk of BA was associated with the T(a)-G(b) (a for rs17095355 and b for rs10509906) haplotype (OR = 1.82, 95% CI = 1.27-2.61) compared with the C(a)-C(b) haplotype.
  
  
  CONCLUSIONS
  This study suggests that the ADD3 gene plays an important role in BA pathogenesis and reveals a significant association between two SNPs, rs17095355 and rs10509906, and BA.
authors.affiliation: Zhuhai Campus of Zunyi Medical College, Zhuhai, Guangdong, China; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Shuaidan
authors.initials: S
authors.lastname: Zeng
authors.affiliation: Zhuhai Campus of Zunyi Medical College, Zhuhai, Guangdong, China; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Zimin
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Jianxiong
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Jianyao
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.affiliation: Zhuhai Campus of Zunyi Medical College, Zhuhai, Guangdong, China; Department of General Surgery, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D001656:Biliary Atresia / Q000235:genetics*; D002148:Calmodulin-Binding Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D000099291:Adducins
chemical_list: D002148:Calmodulin-Binding Proteins; C102021:ADD3 protein, human; D000099291:Adducins