title: Acute brucellosis with typical hemophagocytic lymphohistiocytosis accompanying elevated tumor markers.
abstract: We reported a typical brucellosis, which was diagnosed as hemophagocytic lymphohistiocytosis (HLH). Although some tumor markers (CEA, CYFRA21-1, NSE, CA19-9) in the patient's serum were elevated, carcinomas were excluded by a variety of inspections including bone marrow aspirations, ultrasound examinations, and whole-body PET-CT scans. It was concluded that serum tumor markers are considered medically necessary as a screening test for brucellosis with HLH, however, detailed inspections were needed to make a final diagnosis. Moreover, combination of epidemiology investigations and laboratory inspections were helpful to determine the etiology of HLH and initiate the corresponding treatments.
authors.affiliation: Department of Laboratory Medicine, Affiliated hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.shpchen@hotmail.com.
authors.forename: Xiuyun
authors.initials: X
authors.lastname: Yin
authors.affiliation: Center of Hematopoietic Stem Cell Transplantation, Affiliated hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Yuhang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Laboratory Medicine, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Zeng
authors.affiliation: Department of Laboratory Medicine, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Nong
authors.initials: N
authors.lastname: Yu
authors.affiliation: Department of Laboratory Medicine, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Shiping
authors.initials: S
authors.lastname: Song
authors.affiliation: Department of Laboratory Medicine, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Laboratory Medicine, Affiliated hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Jiankui
authors.initials: J
authors.lastname: Chen
authors.affiliation: Center of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Center of Hematopoietic Stem Cell Transplantation, Affiliated Hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Liangding
authors.initials: L
authors.lastname: Hu
authors.affiliation: Department of Laboratory Medicine, Affiliated hospital of Academy of Military Medical Sciences, Beijing 100071, PR China.
authors.forename: Shuiping
authors.initials: S
authors.lastname: Chen
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D002006:Brucellosis / Q000097:blood / Q000150:complications*; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D006801:Humans; D053539:Keratin-19 / Q000097:blood; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000209:etiology* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; C102012:antigen CYFRA21.1