title: Physical activity and better medication compliance improve mini-mental state examination scores in the elderly.
abstract: In addition to hypertension, dyslipidemia, atherosclerosis, and diabetes, a sedentary lifestyle plays a pivotal role in cerebro- and cardiovascular disease and progressive cognitive decline, including vascular dementia and Alzheimer's disease. The present study investigated whether controlling the key risks and participating in physical activity have a beneficial impact on these disorders. Elderly volunteers were enrolled in a 3-month program that consisted of structured exercise three times per week. The daily routine, medical treatment, and vital parameters were evaluated and correlated with the subjects' neuropsychiatric status. High blood pressure was found in 40% of the participants, with no significant differences between the sexes. A higher proportion of females (55%) than males (18%) forgot to take their medication during the observation period. Significant negative correlations were found between Mini-Mental State Examination (MMSE) scores and age, lack of a caregiver, and increased pulse rate before or after exercise. These results suggest that the presence of home assistance and subsequent improvement in medication compliance, vital parameter optimization, and regular physical activity may yield better MMSE results and a lower risk for cerebro- and cardiovascular disease.
authors.affiliation: Federal University of Viçosa, Viçosa, Brazil.
authors.forename: Fabiana Costa
authors.initials: FC
authors.lastname: Guimarães
authors.forename: Paulo Roberto dos Santos
authors.initials: PR
authors.lastname: Amorim
authors.forename: Fernando Fonseca dos
authors.initials: FF
authors.lastname: Reis
authors.forename: Robson Teixeira
authors.initials: RT
authors.lastname: Bonoto
authors.forename: Wederson Candido de
authors.initials: WC
authors.lastname: Oliveira
authors.forename: Tiago Augusto da Silva
authors.initials: TA
authors.lastname: Moura
authors.forename: Cláudia Loures de
authors.initials: CL
authors.lastname: Assis
authors.forename: András
authors.initials: A
authors.lastname: Palotás
authors.forename: Luciana Moreira
authors.initials: LM
authors.lastname: Lima
mesh_terms: D000368:Aged; D000375:Aging; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011674:Pulse; D018570:Risk Assessment; D012307:Risk Factors; D057185:Sedentary Behavior; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents