title: Serum procalcitonin is a sensitive marker for septic shock and mortality in secondary peritonitis.
abstract: BACKGROUND
  Serum procalcitonin (PCT) is considered to be a sensitive marker for the early recognition of severe infection. The aim of this study was to review the diagnostic accuracy of serum procalcitonin levels to predict the risk of septic shock and mortality in patients with secondary peritonitis.
  
  
  METHODS
  We carried out a retrospective review of patients (November 2010 to November 2012) admitted to the surgical intensive care unit (ICU) with secondary peritonitis classified into localised peritonitis (LP) or diffuse peritonitis (DP) groups. Organ dysfunction was assessed with the SOFA score. Demographic data was collected as well as results for neutrophil count, C- reactive protein, blood lactate, and PCT levels. The primary end-point was ICU mortality.
  
  
  RESULTS
  From a total of 222 patients, 123 were allocated to the LP group and 99 to the DP group. Severe sepsis was observed in 41.9% of all patients in the DP group. The PCT levels increased significantly in the DP group, with the development of septic shock in 29 patients. Higher PCT levels were associated with an increased risk for septic shock with a cut-off value of 15.3 ng mL⁻¹ and an increased risk for mortality with a cut-off value 19.6 ng mL⁻¹. A total of 59.1% of those who developed septic shock died.
  
  
  CONCLUSIONS
  An increase in PCT levels is an indirect sign of diffuse secondary peritonitis and this is associated with an increased risk of septic shock. Increased PCT level on admission is associated with an increased risk of mortality in this category of patients.
authors.affiliation: Department of General and Emergency Surgery, Riga East University Hospital 'Gailezers', Riga, Latvia. aslimnicagp@gmail.com.
authors.forename: Guntars
authors.initials: G
authors.lastname: Pupelis
authors.forename: Nadezda
authors.initials: N
authors.lastname: Drozdova
authors.forename: Maksims
authors.initials: M
authors.lastname: Mukans
authors.forename: Manu L N G
authors.initials: ML
authors.lastname: Malbrain
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D010538:Peritonitis / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011498:Protein Precursors / Q000097:blood*; D012189:Retrospective Studies; D012306:Risk; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000097:blood / Q000150:complications* / Q000401:mortality; D012720:Severity of Illness Index; D012772:Shock, Septic / Q000097:blood / Q000150:complications* / Q000401:mortality
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D019344:Lactic Acid; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide