title: Correlation of IL-1F genetic polymorphisms with the risk of colorectal cancer among Chinese populations.
abstract: Inflammatory/immune cells have the power of infiltrating almost all human solid tumors and influencing all stages of carcinogenesis because of their stimulation of various cytokine subsets. This study aims to determine the correlation of single nucleotide polymorphisms in the IL-17F gene and the risk of colorectal cancer (CRC). One thousand patients diagnosed with CRC and a control group of 354 healthy controls were involved. Peripheral blood samples were collected. The PCR-RFLP method was used to detect the 7383A>G (rs2397084) and 7488T>C (rs763780) in the IL-17F gene. Statistical analyses were conducted with version 12.0 STATA statistical software. We found that the allele model suggested that patients carrying C allele were 1.67 times more likely to develop CRC than healthy controls (odds ratio (OR) = 1.67, 95% confidence interval (CI) = 1.22-2.27, P = 0.001). Similarly, the homozygous and dominant models also revealed that the minor IL-17F 7488C allele conferred an increased CRC risk compared to the major T allele among our study participants (CC vs. TT: OR = 4.15, 95% CI = 1.26-13.36, P = 0.011; TC+CC vs. TT: OR = 1.46, 95% CI = 1.04-2.05, P = 0.027). However, all genetic models indicated that the IL-17F 7383A>G (rs2397084) polymorphism was not associated with CRC risk (all P > 0.05). The results of this study indicate that the 7488T>C (rs763780) in the IL-17F gene may be correlated with increased risk of CRC.
authors.affiliation: Department of Laboratory Medicine, The First Hospital of China Medical University, Nanjing Street No. 155, Heping District, Shenyang, 110000, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
authors.forename: Guo-Jiang
authors.initials: GJ
authors.lastname: Jin
authors.forename: Ke
authors.initials: K
authors.lastname: Yun
authors.forename: Run-Qing
authors.initials: RQ
authors.lastname: Mu
authors.forename: Min
authors.initials: M
authors.lastname: Zhao
authors.forename: Xiao-Ou
authors.initials: XO
authors.lastname: Yu
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Shang
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People; D063646:Carcinogenesis / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C440021:IL17F protein, human; D020381:Interleukin-17