title: Nutritional influences on epigenetic programming: asthma, allergy, and obesity.
abstract: Observational studies show consistent links between early-life nutritional exposures as important risk factors for the development of asthma, allergy, and obesity. Reliance on increasing use of dietary supplementation and fortification (eg, with folate) to compensate for increased consumption of processed foods is also influencing immune and metabolic outcomes. Epigenetics is providing substantial advances in understanding how early-life nutritional exposures can effect disease development. This article summarizes current evidence linking the influence of early-life nutritional exposures on epigenetic regulation with a focus on the disease outcomes of asthma, allergy, and obesity.
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia (M561), Roberts Road, Subiaco, Western Australia 6008, Australia; Members of 'In-FLAME' the International Inflammation Network, World Universities Network (WUN). Electronic address: debbie.palmer@uwa.edu.au.
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Palmer
authors.affiliation: Members of 'In-FLAME' the International Inflammation Network, World Universities Network (WUN); Telethon KIDS Institute, University of Western Australia, Roberts Road, Subiaco, Western Australia 6008, Australia.
authors.forename: Rae-Chi
authors.initials: RC
authors.lastname: Huang
authors.affiliation: Department of Paediatrics, University of Melbourne and Early Life Epigenetics Group, Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Victoria 3052, Australia.
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Craig
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia (M561), Roberts Road, Subiaco, Western Australia 6008, Australia; Members of 'In-FLAME' the International Inflammation Network, World Universities Network (WUN); Telethon KIDS Institute, University of Western Australia, Roberts Road, Subiaco, Western Australia 6008, Australia.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Prescott
mesh_terms: D001249:Asthma / Q000235:genetics* / Q000276:immunology; D065150:Cellular Reprogramming; D004198:Disease Susceptibility; D044127:Epigenesis, Genetic; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology; D009753:Nutritive Value; D009765:Obesity / Q000235:genetics* / Q000276:immunology; D056692:Prebiotics; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena
chemical_list: D015525:Fatty Acids, Omega-3; D056692:Prebiotics
keywords: Allergy; Asthma; Early life; Epigenetic regulation; Nutrition; Obesity