title: [Association between dyslipidemia and 8-OHdG/Cr among a population exposed to chronic arsenic].
abstract: OBJECTIVE
  To explore the association between dyslipidemia and the level of 8-OHdG/Cr in urine among a population exposed to chronic arsenic.
  
  
  METHODS
  Four hundred and seven subjects were randomly selected in an arsenic-affected area in Inner Mongolia. After blood biochemical examination, all the subjects were divided into 4 groups based on the results of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C)and low density lipoprotein cholesterol (LDL-C). The groups consisted of hypercholesterolemia, HDL-C ratio anomaly, combined hypercholesterolemia and HDL-C ratio anomaly, as well as a normal lipid group. Urine samples were collected and 8-OHdG/Cr was measured using the ELISA method. A generalized linear mixed model was used to analyze the association between dyslipidemia and 8-OHdG/Cr.
  
  
  RESULTS
  The levels of 8-OHdG/Cr as 55.73 (39.90-79.94) ng/mg, 58.08 (44.94-69.91)ng/mg, 65.28 (49.29-92.95) ng/mg and 51.43 (36.86-68.57) ng/mgin the HDL-C ratio anomaly, hypercholesterolemia, combined hypercholesterolemia and HDL-C ratio anomaly groups and the control group, respectively, which showed significant differences on the levels of 8-OHdG/Cr in the four groups(P = 0.006). From the linear regression analysis results showed that the 8-OHdG/Cr level in combined hypercholesterolemia and HDL-C ratio anomaly group was higher (4.25 ± 0.55 ng/mg) than in the control group (3.96 ± 0.55 ng/mg) (P = 0.018). After adjusting for important covariates, there was a linear trend between the levels of 8-OHdG/Cr and dyslipidemia (P = 0.016).
  
  
  CONCLUSIONS
  Data from our study showed a linear relation between hypercholesterolemia, HDL-C ratio anomaly and the 8-OHdG/Cr level, suggesting that dyslipidemia was associated with oxidative DNA damage among those .
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Guangyun
authors.initials: G
authors.lastname: Mao
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Haiyang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Chuanwu
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Qiu
authors.affiliation: School of Environmental Science and Public Health, Wenzhou Medical University, Wenzhou 325035, China. Email: gxj@wzmc.edu.cn.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Guo
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D020261:Arsenic Poisoning / Q000453:epidemiology*; D008076:Cholesterol, HDL / Q000097:blood; D002908:Chronic Disease; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D050171:Dyslipidemias / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine