title: [Bronchial asthma pathogenesis and genetic prognosis development].
abstract: The review is dedicated to an actual problem--genetic prognosis of risk of bronchial asthma development that is quite a complex aspect of studies from a methodological viewpoint. Bronchial asthma--heterogeneous disease by both etiology and clinical characteristics. At the same time genetic prognosis is based on the unity of pathogenetic mechanisms of development, though in immunological reactions that are the base of this disease, alternative variants are possible. The aim of this review is carrying out parallels between modern achievements in the field of deciphering trigger mechanisms of bronchial asthma pathogenesis and object of genetic studies based on these mechanisms. Among the examined conceptions--role of epithelial tissue in trigger mechanisms of bronchial asthma, variants of key role of immune system cells, first of all, T-helpers of various types for further development of inflammatory-effector reactions with damage characteristic for this disease. Compliance of contemporary approaches of genetic studies and novel concepts of bronchial asthma pathogenesis is shown.
authors.forename: I P
authors.initials: IP
authors.lastname: Balmasova
authors.forename: R I
authors.initials: RI
authors.lastname: Sepiashvili
authors.forename: Ia R
authors.initials: IaR
authors.lastname: Sepiashvili
authors.forename: E S
authors.initials: ES
authors.lastname: Malova
mesh_terms: D001249:Asthma / Q000235:genetics* / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000473:pathology