title: Association between the 8-item Morisky medication adherence scale (MMAS-8) score and glycaemic control among Chinese diabetes patients.
abstract: Adherence with oral hypoglycaemic agent is crucial to achieve optimal glycaemic control. The 8-item Morisky Medication Adherence Scale (MMAS-8) has been frequently used, yet the association between MMAS-8 score and glycaemic control among Chinese diabetes patients is largely unknown. Two general out-patient clinics were randomly selected in a district with socio-demographic characteristics representative of the entire Hong Kong population. A consecutive sample of adult type-2 diabetes patients currently taking oral hypoglycaemic agents was included. The glycaemic control was reflected by the level of hemoglobin A1c (HbA1c) taken within the previous 6 months. Factors associated with poor glycaemic control (HbA1c ≥ 7.0%) were evaluated by linear regression analysis. From 565 eligible Chinese patients with an average age of 63.2 years (SD 9.7) and male proportion of 46.5%, the average HbA1c was 7.1% (SD 1.1%), and 52.0% had poor glycaemic control. The proportion of poor medication adherence (MMAS-8 ≤ 6) was 32.2%. After controlling for socio-demographics, lifestyle, medication use, and health characteristics, the MMAS-8 score was correlated with better glycaemic control (beta -0.095; 95%CI -0.164 to -0.026, P = .007). The MMAS-8 score had a weak and negative correlation with HbA1c level. The instrument should be applied with caution when predicting glycaemic control in clinical practice.
authors.affiliation: JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Martin C S
authors.initials: MC
authors.lastname: Wong
authors.affiliation: Department of Family Medicine, New Territories East Cluster, Hospital Authority, Hong Kong.
authors.forename: Carmen H M
authors.initials: CH
authors.lastname: Wu
authors.affiliation: JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.|General Practice and Primary Care, Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 9LX, UK.
authors.forename: Harry H X
authors.initials: HH
authors.lastname: Wang
authors.affiliation: Department of Family Medicine, New Territories East Cluster, Hospital Authority, Hong Kong.
authors.forename: Heung Wing
authors.initials: HW
authors.lastname: Li
authors.affiliation: Department of Family Medicine, New Territories East Cluster, Hospital Authority, Hong Kong.
authors.forename: Eric M T
authors.initials: EM
authors.lastname: Hui
authors.affiliation: Department of Family Medicine, New Territories East Cluster, Hospital Authority, Hong Kong.
authors.forename: Augustine T
authors.initials: AT
authors.lastname: Lam
authors.affiliation: JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Roger Y N
authors.initials: RY
authors.lastname: Chung
authors.affiliation: JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Benjamin H K
authors.initials: BH
authors.lastname: Yip
authors.affiliation: Department of Community Health Sciences, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Morisky
mesh_terms: D000284:Administration, Oral; D000368:Aged; D044466:Asian People / Q000523:psychology; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002681:China; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000208:ethnology / Q000523:psychology; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D007722:Health Knowledge, Attitudes, Practice / Q000208:ethnology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D016014:Linear Models; D008297:Male; D055118:Medication Adherence / Q000208:ethnology; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; C517652:hemoglobin A1c protein, human
keywords: MMAS-8; Morisky Medication Adherence Scale; associated factors; glycaemic control; oral hypoglycaemic agents; primary care