title: Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment.
abstract: Postnatal cytomegalovirus (CMV) infection is common in neonates and is mostly acquired through infected breast milk from seropositive mothers. In this review, risk factors of postnatal CMV transmission and predictors of severity, preventive measures and treatment of symptomatic postnatal CMV infection in preterm infants are discussed. Several viral, transmission route and host factors have been associated with a higher risk of postnatal CMV transmission from mother to child. Severity predictors of symptomatic postnatal CMV infection may include extreme prematurity (gestational age <26 weeks), timing of postnatal infection as well as comorbidities. Further research in postnatally infected preterm infants at risk for severe symptoms is essential with respect to preventive measures involving the infected breast milk and antiviral treatment.
authors.affiliation: Department of Neonatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
authors.forename: Julia
authors.initials: J
authors.lastname: Gunkel
authors.forename: Tom F W
authors.initials: TF
authors.lastname: Wolfs
authors.forename: Linda S
authors.initials: LS
authors.lastname: de Vries
authors.forename: Joppe
authors.initials: J
authors.lastname: Nijman
mesh_terms: D003586:Cytomegalovirus Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy* / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature
keywords: postnatal cytomegalovirus infection; predictor; preterm infants; risk factor; severity; symptoms; treatment