title: Single center experience of endoscopic submucosal dissection (ESD) in early Barrett's adenocarcinoma.
abstract: BACKGROUND
  Endoscopic mucosal resection (EMR) or radical surgical resection are the standard treatment options for patients with early Barrett's adenocarcinoma (EBAC). Endoscopic submucosal dissection (ESD) is a new endoscopic technique, which allows--in contrast to EMR--endoscopic en-bloc resection of neoplastic lesions greater than 2 cm with complete histological evaluation of the resected specimen. In contrast to Western countries, Barrett's esophagus is less common in Asia indicating the low volume of published data of ESD in EBAC in Japanese series. Therefore, the aim of the present study is to describe the results of ESD in patients with EBAC performed in a German tertiary referral center.
  
  
  METHODS
  Between November 2009 and April 2014 ESDs were performed in 22 patients with histologically proven EBAC. Data were given for the en-bloc, the R0, the R0 en-bloc, and the curative resection rate as well as for the complication and the local recurrence rate.
  
  
  RESULTS
  ESD was technically possible in all of the 22 patients. 20 of the resected EBAC were mucosal carcinomas, whereas in two patients the tumor showed submucosal invasion. The en-bloc, R0, R0 en-bloc, and curative resection rates were 95.5, 81.8, 81.8 %, and 77.3 %, resp. Complication rate was 27.3 % (perforation n = 1, bleeding n = 2, stenosis n = 3). In case of curative tumor resection, only one local tumor recurrence (5.9 %) occurred after a medium follow-up of 1.6 years.
  
  
  CONCLUSIONS
  Despite the small number of patients and a relatively short follow-up, the present data underline the value of ESD, especially in case of curative resections in the definite and less invasive therapy of EBAC. Attention should be drawn toward subsquamous extension of EBAC requiring a sufficient safety margin as an obligate condition for curative R0 resections. Due to the required learning curve and the management of potential complications, ESD should be restricted to greater endoscopic centers.
authors.affiliation: Department of Gastroenterology & Interventional Endoscopy; Asklepios Hospital Barmbek, Medical Faculty, Semmelweis University, Campus Hamburg, Rübenkamp 220, 22291, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Höbel
authors.forename: P
authors.initials: P
authors.lastname: Dautel
authors.forename: R
authors.initials: R
authors.lastname: Baumbach
authors.forename: K-J
authors.initials: KJ
authors.lastname: Oldhafer
authors.forename: A
authors.initials: A
authors.lastname: Stang
authors.forename: B
authors.initials: B
authors.lastname: Feyerabend
authors.forename: N
authors.initials: N
authors.lastname: Yahagi
authors.forename: C
authors.initials: C
authors.lastname: Schrader
authors.forename: S
authors.initials: S
authors.lastname: Faiss
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery*; D000368:Aged; D001471:Barrett Esophagus / Q000601:surgery*; D004210:Dissection / Q000009:adverse effects / Q000379:methods*; D004938:Esophageal Neoplasms / Q000601:surgery*; D004945:Esophagoscopy / Q000295:instrumentation* / Q000379:methods*; D005260:Female; D005753:Gastric Mucosa / Q000601:surgery; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D016896:Treatment Outcome