title: Swept-source OCT angiography of macular telangiectasia type 2.
abstract: OBJECTIVE
  To evaluate the central macular microvascular network in patients with macular telangiectasia type 2 (MacTel2) using optical coherence tomography (OCT)-based microangiography (OMAG).
  
  
  METHODS
  Prospective, observational study of patients with MacTel2 evaluated using a swept-source OCT (SS-OCT) prototype. OMAG was performed using a 3 mm × 3 mm central foveal raster scan. The algorithm segmented the retina into three layers. Microvascular distribution was depicted as en face images, and qualitative information was compared to fluorescein angiography (FA) images.
  
  
  RESULTS
  OMAG detected abnormal microvasculature in all MacTel2 eyes, predominantly in the middle retinal layers with neovascularization in the outer retina. These vessels correlated well with the FA alterations. The abnormal temporal, juxtafoveal microvasculature in MacTel2 became apparent as the disease progressed and in later stages tended to extend circumferentially, with anastomotic vessels temporally.
  
  
  CONCLUSIONS
  OMAG provided detailed, depth- resolved information about the perifoveal macular microvasculature in MacTel2. In most cases, images were better using OMAG than FA. The OMAG images demonstrated that most of the leakage seen on FA appeared to arise from the abnormal perifoveal microvasculature in the middle retinal layer.
authors.forename: Mariana R
authors.initials: MR
authors.lastname: Thorell
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yanping
authors.initials: Y
authors.lastname: Huang
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.forename: Michal
authors.initials: M
authors.lastname: Laron
authors.forename: Utkarsh
authors.initials: U
authors.lastname: Sharma
authors.forename: Paul F
authors.initials: PF
authors.lastname: Stetson
authors.forename: Giovanni
authors.initials: G
authors.lastname: Gregori
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenfeld
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005240:Feasibility Studies; D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012164:Retinal Diseases / Q000175:diagnosis* / Q000209:etiology; D012171:Retinal Vessels / Q000473:pathology*; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000150:complications* / Q000175:diagnosis; D041623:Tomography, Optical Coherence / Q000379:methods*