title: Novel therapeutic strategies for adult obese asthmatics.
abstract: Asthma is a complex syndrome that affects an estimated 26 million people in the United States but gaps exist in the recognition and management of asthmatic subgroups. This article proposes alternative approaches for future treatments of adult obese asthmatics who do not respond to standard controller therapies, drawing parallels between seemingly disparate therapeutics through their common signaling pathways. How metformin and statins can potentially improve airway inflammation is described and supplements are suggested. A move toward more targeted therapies for asthma subgroups is needed. These therapies address asthma and the comorbidities that accompany obesity and metabolic syndrome to provide the greatest therapeutic potential.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Linderholm
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Bratt
authors.affiliation: Nutrition Department, University of California, Davis, 430 West Health Sciences Drive, Davis, CA, USA; Immunity and Diseases Prevention Unit, Western Human Nutrition Research Center, United States Department of Agriculture (USDA), Agricultural Research Services (ARS), 430 West Health Sciences Drive, Davis, CA, USA.
authors.forename: Gertrud U
authors.initials: GU
authors.lastname: Schuster
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Zeki
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of California, Davis, 4150 V Street, Suite 3100, Davis, CA, USA. Electronic address: njkenyon@ucdavis.edu.
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Kenyon
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism; D000328:Adult; D056151:Airway Remodeling / Q000187:drug effects; D001120:Arginine / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D019587:Dietary Supplements; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D018836:Inflammation Mediators / Q000378:metabolism; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use*; D058990:Molecular Targeted Therapy; D009765:Obesity / Q000188:drug therapy*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D018836:Inflammation Mediators; D008687:Metformin; D001120:Arginine; D000263:Adenylate Kinase
keywords: Metformin; Nitric oxide; Obesity; Severe asthma; Statins; l-Arginine