title: A treatment study of canine symmetrical onychomadesis (symmetrical lupoid onychodystrophy) comparing fish oil and cyclosporine supplementation in addition to a diet rich in omega-3 fatty acids.
abstract: BACKGROUND
  Treatment of symmetrical onychomadesis (symmetrical lupoid onychodystrophy) is a challenging task for dermatologists. The acute phase is characterized by sloughing of claw plates and loose claws have to be removed and secondary infections treated. The goal of long-term treatment is to allow claws to re-grow with normal quality and to achieve life-long lack of recurrence. The aim of this randomized treatment trial was to see if adding fish oil or cyclosporine to a diet rich in omega-3 could improve the treatment outcome of symmetrical onychomadesis in Gordon and English setters. All dogs were fed Eukanuba Veterinary Diets Dermatosis® exclusively during the six month treatment trial. The treatment outcome was measured as the change in number of healthy claws during treatment, as well as the long-term effect on hunting ability and recurrence of onychomadesis. The hypothesis was that cyclosporine provides a stronger and different immune modulating property than fish oil and therefore would give a better treatment outcome in dogs with symmetrical onychomadesis eating a diet rich in omega-3 fatty acids.
  
  
  RESULTS
  Six Gordon setters and one English setter were treated with 5 mg/kg cyclosporine once daily for six months and seven Gordon setters were treated with 10 ml Dr Baddaky fish oil® once daily for six months. All dogs were evaluated every month and the numbers of healthy claws were recorded.
  
  
  CONCLUSIONS
  Cyclosporine and fish oil appeared to be equally effective in treating symmetrical onychomadesis when the dog is fed a diet high in omega-3.
authors.forename: Martine L
authors.initials: ML
authors.lastname: Ziener
authors.forename: Ane
authors.initials: A
authors.lastname: Nødtvedt
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000627:therapeutic use*; D004032:Diet; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000276:immunology*; D005395:Fish Oils / Q000627:therapeutic use*; D009260:Nail Diseases / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D016572:Cyclosporine