title: Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease.
abstract: The aim of this study was to investigate the effects of probiotic yogurt consumption on some metabolic factors in nonalcoholic fatty liver disease (NAFLD) patients. This double-blind, randomized, controlled clinical trial was conducted on 72 patients with NAFLD (33 males and 39 females) aged 23 to 63 yr. Subjects in the intervention group (n=36) consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group (n=36) consumed 300 g/d of conventional yogurt for 8 wk. Fasting blood samples, anthropometric measurements, and dietary records (24h/d for 3 d) were collected at baseline and at the end of the trial. Probiotic yogurt consumption resulted in reductions of 4.67, 5.42, 4.1, and 6.92% in serum levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and low-density lipoprotein cholesterol, respectively, compared with control group. No significant changes were observed in levels of serum glucose, triglycerides, or high-density lipoprotein cholesterol in either group. Probiotic yogurt consumption improved hepatic enzymes, serum total cholesterol, and low-density lipoprotein cholesterol levels in studied subjects and might be useful in management of NAFLD risk factors.
authors.affiliation: Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, 51666-14711 Tabriz, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Nabavi
authors.affiliation: Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, 51666-14711 Tabriz, Iran. Electronic address: rafrafm@tbzmed.ac.ir.
authors.forename: M
authors.initials: M
authors.lastname: Rafraf
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, 51666-14711 Tabriz, Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Somi
authors.affiliation: Department of Food Science and Technology, Faculty of Nutrition, Tabriz University of Medical Sciences, 51666-14711 Tabriz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Homayouni-Rad
authors.affiliation: Health Management of National Center and Department of Statistics and Epidemiology, Faculty of Health, Tabriz University of Medical Sciences, 51666-14711 Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Asghari-Jafarabadi
mesh_terms: D000328:Adult; D000818:Animals; D001644:Bifidobacterium; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007779:Lactobacillus acidophilus; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000628:therapy*; D019936:Probiotics / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood; D015014:Yogurt / Q000382:microbiology*; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: metabolic factor; nonalcoholic fatty liver disease; probiotic yogurt