title: Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles.
abstract: Novel antibacterial nanomaterials have been developed for biomedical applications. The present study involves the preparation and properties of antibacterial nanofibers from chitosan/polyethylene oxide electrospun nanofibers incorporated with silver nanoparticles. Silver nanoparticles were efficiently synthesized in situ after ultra violet (UV) with AgNO3 as precursor and chitosan/polyethylene oxide as reducing agent and protecting agent, respectively. Then the resultant solutions were electrospun into nanofibers. The formation of silver nanoparticles was confirmed with ultraviolet visible (UV-vis) and transmission electron microscopy (TEM), and the electrospun nanofibers were characterized by scanning electron microscopy and energy dispersive X-ray. The resultant fibers exhibited uniform morphology with silver nanoparticles distributed throughout the fiber. Also, the fibers showed certain tensile strength and excellent antibacterial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. Sustained release of silver nanoparticles from fibers could last for over 72 h. The silver-containing chitosan/polyethylene oxide nanofibers showed excellent cytocompatibility.
authors.affiliation: Key Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, P. R. China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, P. R. China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, P. R. China gao2001jing@dhu.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.affiliation: Key Laboratory of Textile Science & Technology of Ministry of Education, College of Textiles, Donghua University, Shanghai, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001458:Bandages / Q000009:adverse effects; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry / Q000633:toxicity / Q000648:ultrastructure; D036103:Nanotechnology; D011092:Polyethylene Glycols / Q000737:chemistry; D012834:Silver / Q000008:administration & dosage; D013211:Staphylococcus aureus / Q000187:drug effects; D013552:Swine; D013718:Tensile Strength
chemical_list: D000900:Anti-Bacterial Agents; D012834:Silver; D011092:Polyethylene Glycols; D048271:Chitosan
keywords: Electrospinning; antibacterial dressing; chitosan; nanofibers; silver nanoparticles