title: The coincidence of familial mediterranean Fever and hypereosinophilia in a patient with hereditary elliptocytosis.
abstract: Familial Mediterranean fever (FMF) is a genetic disease with autosomal inheritance characterized by recurrent fever, abdominal pain, and serositis attacks. It is relatively common in the races and ethnical groups around Mediterranean Sea (Sephardic Jews, Armenians, Turks and Arabians). Hereditary elliptocytosis (HE) is common genetic defect of the red blood cell membrane skeleton. Spectrin mutations are the predominant causes of HE. Hypereosinophilia is defined as a number of eosinophil granulocytes equal or greater than 0.5 × 10(9)/L of circulating blood. The main causes are allergies and parasitic infections. This case report describes a Turkish female HE patient who presented with FMF and hypereosinophilia. Genetic analysis revealed heterozygous mutation in exon 10 of the MEFV gene (V726A). The patient was successfully treated with colchicine and steroid treatment at 3-month follow-up. To the best of our knowledge, this is the first report of association between FMF, HE, and hypereosinophilia.
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Keklik
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Ali
authors.initials: A
authors.lastname: Unal
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Serdar
authors.initials: S
authors.lastname: Sivgin
authors.affiliation: Department of Pathology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Olgun
authors.initials: O
authors.lastname: Kontas
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Eroglu
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Yilmaz
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Leylagul
authors.initials: L
authors.lastname: Kaynar
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Bulent
authors.initials: B
authors.lastname: Eser
authors.affiliation: Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey 38039.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cetin
keywords: Familial Mediterranean fever; Hereditary elliptocytosis; Hypereosinophilia