title: [Protective role of the G allele of the polymorphism in the Interleukin 10 gene (-1082G/A) against the development of preeclampsia].
abstract: OBJECTIVE
  To identify the frequency of polymorphism in the IL-10 gene, rs1800896 (-1082 A/G), in women with preeclampsia (PE) and in women in a control group and to associate the presence of this polymorphism with protection against the development of PE.
  
  
  METHODS
  This was a case-control study conducted on 54 women with PE, classified according to the criteria of the National High Blood Pressure Education Program, and on 172 control women with at least two healthy pregnancies. The proposed polymorphism was studied by the technique of real time polymerase chain reaction (qPCR), with hydrolysis probes. Statistical analysis was performed using the χ2 test. Odds ratio and confidence interval of 95% were used to measure the strength of association between the studied polymorphism and the development of PE.
  
  
  RESULTS
  Statistically increased frequency of the AG genotype was observed among control women (85 versus 15% in women with PE). The G allele was significantly more frequent among control women than PE women (χ2 test, p = 0.01). The odds ratio for carriers of the G allele was 2.13, indicating a lower risk of developing PE compared to non-carriers.
  
  
  CONCLUSIONS
  Thus, an association is suggested to occur between the presence of the G allele of the polymorphism in the IL-10 rs1800896 (-1082 A/G) gene and protection against the development of PE. More studies investigating the contribution of these variations and the mechanisms by which they affect the risk of developing PE still need to be undertaken.
authors.affiliation: Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Cristina Wide
authors.initials: CW
authors.lastname: Pissetti
authors.affiliation: Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Thiago Mantello
authors.initials: TM
authors.lastname: Bianco
authors.affiliation: Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Sarah Cristina Sato Vaz
authors.initials: SC
authors.lastname: Tanaka
authors.affiliation: Disciplina de Microbiologia e Imunologia, Instituto Federal do Triângulo Mineiro, Uberaba, MG, Brasil.
authors.forename: Gabriel Antonio Nogueira
authors.initials: GA
authors.lastname: Nascentes
authors.affiliation: Disciplina de Genética, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Roseane Lopes da Silva
authors.initials: RL
authors.lastname: Grecco
authors.affiliation: Disciplina Enfermagem em Ginecologia e Obstetrícia, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Sueli Riul
authors.initials: SR
authors.lastname: da Silva
authors.affiliation: Disciplina de Genética, Universidade Federal do Triângulo Mineiro - UFTM, Uberaba, MG, Brasil.
authors.forename: Marly Aparecida Spadotto
authors.initials: MA
authors.lastname: Balarin
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D055815:Young Adult
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10