title: Protection of salvianolate against atherosclerosis via regulating the inflammation in rats.
abstract: Inflammation plays an essential role in the pathophysiology of atherosclerosis. Our study was aimed to investigate whether salvianolate, a novel water-soluble phenolic compound of Danshen, alleviates atherosclerosis via regulating the inflammation in rats. High fat diet feeding plus vitamin D3 injection was used to induce atherosclerosis in rats. Salvianolate (60, 120 or 240 mg/kg) or placebo was given to atherosclerotic rats. The plasma lipids, interleukin 6 (IL-6) and C reactive protein (CRP) were measured by ELISA. CD4+CD25+Foxp3+ cells were determined by flow cytometry. Histological changes were examined by hematoxylin and eosin staining. The results showed that the levels of plasma IL-6 and CRP were elevated in the rats fed on high fat diet, and the histological analysis demonstrated the successful establishment of atherosclerosis models. Treatment with salvianolate alleviated the atherosclerotic process and decreased the levels of plasma IL-6 and CRP. Also the number of CD4+CD25+Foxp3+ cells was increased in salvianolate-treated rats. It was concluded that salvianolate could treat atherosclerosis via modulating the inflammation at cytokine and cell levels.
authors.affiliation: Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang, 261031, China.
authors.forename: Chun
authors.initials: C
authors.lastname: Meng
authors.affiliation: Department of Cardiology, Provincial Hospital Affiliated to Shandong University, Ji'nan, 250021, China.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Zhuo
authors.affiliation: Department of Emergency, Affiliated Hospital of Weifang Medical College, Weifang, 261031, China.
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Affiliated Hospital of Weifang Medical College, Weifang, 261031, China. JianliL66@126.com.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Liu
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D002097:C-Reactive Protein / Q000378:metabolism; D002762:Cholecalciferol / Q000008:administration & dosage; D059305:Diet, High-Fat / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D051858:Forkhead Transcription Factors / Q000378:metabolism; D007249:Inflammation / Q000097:blood / Q000517:prevention & control*; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D018655:Lymphocyte Count; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D017208:Rats, Wistar; D017463:Receptors, Complement 3b / Q000378:metabolism; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000378:metabolism; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D051858:Forkhead Transcription Factors; C500522:Foxp3 protein, rat; D015850:Interleukin-6; D008055:Lipids; D010936:Plant Extracts; D017463:Receptors, Complement 3b; D014815:Vitamins; C561960:salvianolate; D002762:Cholecalciferol; D002097:C-Reactive Protein