title: Meta analysis of association of the IL-17F rs763780T>C gene polymorphism with cancer risk.
abstract: OBJECTIVE
  To investigate the association of IL-17F rs763780T>C with cancer risk.
  
  
  METHODS
  We searched the Cochrane Central Library, PubMed, MEDLINE, EMBASE, CNKI (China National Knowledge Infrastructure) and WangFang databases until May 2014 for a meta-analysis conducted using RevMan 5.2 software.
  
  
  RESULTS
  A total of ten papers were included into this meta analysis, involving 3, 336 cases and 4, 217 healthy people. There were no significant differences on association of IL-17F rs763780T>C polymorphism with cancer risk except in the CC vs TT genetic model. Although the the risk in the gastric cancer group is higher than that in control group, there were no significant differences on the association of IL-17F rs763780T>C polymorphism with other cancers.
  
  
  CONCLUSIONS
  Our meta analysis reveal the IL-17A rs763780T>C gene polymorphism is involved in risk of gastric cancer but not other tumor types.
authors.affiliation: Department of Medical Quality Control, West China Hospital, Sichuan University, Chengdu, ChinaE-mail : jake.chenxj@gmail.com.
authors.forename: Xiang-Jun
authors.initials: XJ
authors.lastname: Chen
authors.forename: Tao-You
authors.initials: TY
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Pu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: C440021:IL17F protein, human; D020381:Interleukin-17