title: Evaluation of oxaliplatin exposure of healthcare workers during heated intraperitoneal perioperative chemotherapy (HIPEC).
abstract: The aim of this study was to evaluate air and surface contaminations, and internal contamination of healthcare workers during open-abdomen HIPEC using oxaliplatin. Platinum (Pt) was measured in urine of exposed workers and in multiple air and surface samples. Three successive HIPEC procedures were investigated in each of the two hospitals participating in the study. Analysis of air samples did not detect any oxaliplatin contamination. Heavy contamination of the operating table, the floor at the surgeon's feet, and the surgeon's overshoes were observed. Hand contamination was observed in surgeons using double gloves for intra-abdominal chemotherapy administration, but not in those using three sets of gloves. Pt was not detected in urine samples obtained after HIPEC (<5 ng/L). The main risk of HIPEC is related to direct or indirect skin exposure and can be prevented by correct use of adapted protective equipment.
authors.affiliation: Poison Centre, Occupational and Environmental Unit, Fernand Widal Hospital, France.
authors.forename: Antoine F
authors.initials: AF
authors.lastname: Villa
authors.forename: Souleiman
authors.initials: S
authors.lastname: El Balkhi
authors.forename: Radia
authors.initials: R
authors.lastname: Aboura
authors.forename: Herve
authors.initials: H
authors.lastname: Sageot
authors.forename: Helene
authors.initials: H
authors.lastname: Hasni-Pichard
authors.forename: Marc
authors.initials: M
authors.lastname: Pocard
authors.forename: Dominique
authors.initials: D
authors.lastname: Elias
authors.forename: Nathalie
authors.initials: N
authors.lastname: Joly
authors.forename: Didier
authors.initials: D
authors.lastname: Payen
authors.forename: François
authors.initials: F
authors.lastname: Blot
authors.forename: Joel
authors.initials: J
authors.lastname: Poupon
authors.forename: Robert
authors.initials: R
authors.lastname: Garnier
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000032:analysis* / Q000652:urine; D010478:Chemotherapy, Cancer, Regional Perfusion; D005260:Female; D005430:Floors and Floorcoverings; D005932:Gloves, Surgical; D006225:Hand; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis* / Q000517:prevention & control; D009873:Operating Rooms; D058638:Operating Tables; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000032:analysis* / Q000652:urine; D000077150:Oxaliplatin; D010534:Peritoneal Neoplasms / Q000601:surgery / Q000628:therapy*; D010564:Personnel, Hospital; D012775:Shoes; D055815:Young Adult
chemical_list: D000395:Air Pollutants, Occupational; D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin