title: The complex portal--an encyclopaedia of macromolecular complexes.
abstract: The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/complex), through which protein complexes from major model organisms are being collated and made available for search, viewing and download. It has been built in close collaboration with other bioinformatics services and populated with data from ChEMBL, MatrixDB, PDBe, Reactome and UniProtKB. Each entry contains information about the participating molecules (including small molecules and nucleic acids), their stoichiometry, topology and structural assembly. Complexes are annotated with details about their function, properties and complex-specific Gene Ontology (GO) terms. Consistent nomenclature is used throughout the resource with systematic names, recommended names and a list of synonyms all provided. The use of the Evidence Code Ontology allows us to indicate for which entries direct experimental evidence is available or if the complex has been inferred based on homology or orthology. The data are searchable using standard identifiers, such as UniProt, ChEBI and GO IDs, protein, gene and complex names or synonyms. This reference resource will be maintained and grow to encompass an increasing number of organisms. Input from groups and individuals with specific areas of expertise is welcome.
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom bmeldal@ebi.ac.uk.
authors.forename: Birgit H M
authors.initials: BH
authors.lastname: Meldal
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Oscar
authors.identifier: http://orcid.org/0000-0003-1940-5836
authors.initials: O
authors.lastname: Forner-Martinez
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5477, USA.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Costanzo
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Jose
authors.initials: J
authors.lastname: Dana
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5477, USA.
authors.forename: Janos
authors.initials: J
authors.lastname: Demeter
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Marine
authors.initials: M
authors.lastname: Dumousseau
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5477, USA.
authors.forename: Selina S
authors.initials: SS
authors.lastname: Dwight
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Anna
authors.initials: A
authors.lastname: Gaulton
authors.affiliation: Department of Biology, University of Rome, Tor Vergata, Rome 00133, Italy.
authors.forename: Luana
authors.initials: L
authors.lastname: Licata
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Anna N
authors.initials: AN
authors.lastname: Melidoni
authors.affiliation: UMR 5086 CNRS, Université Lyon1, Institut de Biologie et Chimie des Protéines, 7 passage du Vercors, 69367 Lyon Cedex 07, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ricard-Blum
authors.affiliation: Swiss-Prot Group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, Geneva, Switzerland.
authors.forename: Bernd
authors.initials: B
authors.lastname: Roechert
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5477, USA.
authors.forename: Marek S
authors.initials: MS
authors.lastname: Skyzypek
authors.affiliation: Stammzellbiologie, Institut für Anatomie und Zellbiologie, GZMB Universitätsmedizin Göttingen, Ernst-Caspari-Haus, Justus-von-Liebig-Weg 11, 37077 Göttingen, Germany.
authors.forename: Manu
authors.initials: M
authors.lastname: Tiwari
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Sameer
authors.initials: S
authors.lastname: Velankar
authors.affiliation: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5477, USA.
authors.forename: Edith D
authors.initials: ED
authors.lastname: Wong
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.affiliation: European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, United Kingdom.
authors.forename: Sandra
authors.initials: S
authors.lastname: Orchard
mesh_terms: D000818:Animals; D001665:Binding Sites; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D046911:Macromolecular Substances / Q000737:chemistry; D051379:Mice; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D046911:Macromolecular Substances; D011506:Proteins