title: Effect of caffeic acid derivatives on polychlorinated biphenyls induced hepatotoxicity in male mice.
abstract: Chronic exposure to coplanar polychlorinated biphenyls (PCBs), a potent inducer of toxic reactive oxygen species (ROS), in the environment and food can cause liver diseases. It remains unknown whether caffeic acid derivatives (CADs) exerted protective effect on PCB-induced hepatotoxicity. We sought to evaluate the activities of 3 CADs on PCB169-induced oxidative stress and DNA damage in the liver. Male ICR mice were administered with 1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks. The mice were given CADs by gastric gavage for 3 weeks. We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase (SOD), glutathione (GSH) and GSH peroxidase (GPx). It increased the liver weight, malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and CYP1A1 activity in the liver tissues and plasma of mice (P<0.05). Pretreatment of mice with CADs restored the above parameters to normal levels. There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYP1A1 and phase II metabolism enzyme (SOD, GPx) activities (P<0.05). In conclusion, PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.
authors.affiliation: The First People's Hospital of Suqian, Suqian, Jiangsu 223800, Chian.
authors.forename: Ruirui
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Cao
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Dai
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Yubang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Wenqin
authors.initials: W
authors.lastname: Yin
authors.affiliation: Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ye
keywords: 8-OHdG; PCB169; caffeic acid derivatives (CADs); hepatotoxicity; synergy