title: Potential drug-drug interactions in prescriptions dispensed in community and hospital pharmacies in East of Iran.
abstract: OBJECTIVE
  This study aim to evaluate and compare type and prevalence of drug-drug interactions (DDIs) in prescriptions dispensed in both community and hospital setting in Zabol, Iran.
  
  
  METHODS
  A total of 2796 prescriptions were collected from community and inpatient and outpatient pharmacy of Amir-al-momenin only current acting hospital in Zabol, Iran. The prescriptions were processed using Lexi-Comp drug interaction software. The identified DDIs were categorized into five classes (A, B, C, D, X).
  
  
  RESULTS
  Overall 41.6% of prescriptions had at last one potential DDI. The most common type of interactions was type C (66%). The percentage of drug interactions in community pharmacies were significantly lower than hospital pharmacies (P < 0.0001).
  
  
  CONCLUSIONS
  Our results indicate that patients in Zabol are at high risk of adverse drug reactions caused by medications due to potential DDIs. Appropriate education for physicians about potentially harmful DDIs, as well as active participation of pharmacists in detection and prevention of drug-related injuries, could considerably prevent the consequence of DDIs among patients.
authors.affiliation: Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Mandana Moradi
authors.initials: MM
authors.lastname: Dirin
authors.affiliation: Department of Clinical Pharmacy and Pharmacy Practice, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mousavi
authors.affiliation: Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Amir Reza
authors.initials: AR
authors.lastname: Afshari
authors.affiliation: Department of Pharmacology and Toxicology, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Kaveh
authors.initials: K
authors.lastname: Tabrizian
authors.affiliation: Department of Clinical Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Ashrafi
keywords: Community pharmacy services; Iran; drug interactions; hospital pharmacy services; prescriptions