title: A new TIPE of phosphoinositide regulator in cancer.
abstract: Specific phosphoinositide lipids promote cell growth and cancer. In this issue of Cancer Cell, Fayngerts and colleagues demonstrate that the TIPE3 protein enhances PtdIns(4,5)P2 and PtdIns(3,4,5)P3, is overexpressed in certain cancers, and promotes tumorigenesis. TIPE3 can act as a lipid transfer protein and may constitute a novel phosphoinositide metabolism regulator.
authors.affiliation: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address: l.moniz@ucl.ac.uk.
authors.forename: Larissa S
authors.initials: LS
authors.lastname: Moniz
authors.affiliation: UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address: bart.vanh@ucl.ac.uk.
authors.forename: Bart
authors.initials: B
authors.lastname: Vanhaesebroeck
mesh_terms: D063646:Carcinogenesis; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism* / Q000502:physiology
chemical_list: D010716:Phosphatidylinositols