title: Perspectives in Pediatric Pathology, Chapter 22. Testicular Involvement in Systemic Diseases.
abstract: Normal testicular physiology requires appropriate function of endocrine glands and other tissues. Testicular lesions have been described in disorders involving the hypothalamus-hypophysis, thyroid glands, adrenal glands, pancreas, liver, kidney, and gastrointestinal tract. Testicular abnormalities can also associate with chronic anemia, obesity, and neoplasia. Although many of the disorders that affect the above-mentioned glands and tissues are congenital, acquired lesions may result in hypogonadism in children and adolescents.
authors.affiliation: 1 Department of Pathology, Hospital La Paz, Universidad Autónoma de Madrid, Madrid 28029, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Nistal
authors.affiliation: 2 Department of Cell Biology, Universidad de Alcala, Madrid, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Paniagua
authors.affiliation: 1 Department of Pathology, Hospital La Paz, Universidad Autónoma de Madrid, Madrid 28029, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: González-Peramato
authors.affiliation: 3 Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA 15224, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Reyes-Múgica
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004700:Endocrine System Diseases / Q000150:complications; D006801:Humans; D008297:Male; D013733:Testicular Diseases / Q000209:etiology* / Q000473:pathology*
keywords: chronic liver failure; chronic renal failure; cystic fibrosis; endocrine pathology; testicular pathology