title: Inhibitation of cellular toxicity of gold nanoparticles by surface encapsulation of silica shell for hepatocarcinoma cell application.
abstract: Nanotechnology, as a double-edged sword, endows gold nanoparticles (GNPs) more "power" in bioimaging and theragnostics, whereas an outstanding issue associated with the biocompatibility of GNPs should also be addressed. Especially for the silica-coated gold nanospheres (GNSs) and gold nanorods (GNRs), there is increasing attention to explore the application, because the surface silica encapsulation has been proved to be an alternative strategy for other organic surface coatings. However, among those reports there are very limited publications to focus on the toxicity of silica-coated GNSs and GNRs. Besides, the existing detoxification methods via surface chemistry on GNPs greatly improve the biocompatibility but still undergo challenges for high dose (>100 pM) demand and long-term stability. Here, we demonstrated a straightforward, low-cost, universal strategy for the surface chemistry on GNPs via silica encapsulating. Different size, shape, dose, and surface capping of GNPs for the nanotoxicity test have been carefully discussed. After silica encapsulating, the detoxification for all GNPs presents significantly from HepG2 cell proliferation results, especially for the GNRs. This new straightforward strategy will definitely rationalize the biocompatibility issue of GNPs and also provide potential for other surface chemistry methodology in biomedical fields.
authors.affiliation: State Key Laboratory of Luminescence and Applications, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences , Dong_Nanhu Road 3888, Changchun, Jilin 130033, P. R. China.
authors.forename: Qinghui
authors.initials: Q
authors.lastname: Zeng
authors.forename: Youlin
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wenyu
authors.initials: W
authors.lastname: Ji
authors.forename: Weiguang
authors.initials: W
authors.lastname: Ye
authors.forename: Yinglei
authors.initials: Y
authors.lastname: Jiang
authors.forename: Jie
authors.initials: J
authors.lastname: Song
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D000077286:Cetrimonium; D002593:Cetrimonium Compounds; D019343:Citric Acid; D006046:Gold / Q000737:chemistry* / Q000633:toxicity*; D056945:Hep G2 Cells; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity*; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity; D043942:Nanotubes; D010316:Particle Size; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D002593:Cetrimonium Compounds; D053769:Nanocapsules; D019343:Citric Acid; D006046:Gold; D012822:Silicon Dioxide; D000077286:Cetrimonium
keywords: HepG2 cells; cancer therapy; gold nanorods; gold nanospheres; nanotoxicity; silica encapsulation