title: [A case of ophthalmic artery occlusion following injection of hyaluronic acid into the glabellar area].
abstract: OBJECTIVE
  We report a case of unilateral blindness due to ophthalmic artery occlusion following injection of hyaluronic acid into the glabellar area for facial soft-tissue augmentation.
  
  
  METHODS
  A 20-year old woman underwent injection of hyaluronic acid into the glabellar area at an aesthetic plastic clinic. Immediately after injection, she suffered nausea, pain, paralysis of limbs and visual loss in her right eye. Hyaluronidase was instanly injected into the same place, but these symptoms did not improve. She was transferred to our hospital's emergency department. At the first examination, she had no light perception in the right eye and her right pupil was dilated. The fundus examination revealed right central artery occlusion. No significant findings were detected in her head. Eye ball massage, hyperbaric oxygen therapy, and drip infusion of urokinase were conducted, but no improvement resulted. Fluorescein and indocyanine green angiography showed no filling of the right retinal and choroidal arteries. Electroretinogram was completely disappeared. Magnetic resonance angiography could not reveal the obstruction point of the ophthalmic artery.
  
  
  CONCLUSIONS
  Ophthalmic artery occlusion was believed to have occured after injection of hyaluronic acid into the glabellar area.
authors.forename: Sakiko
authors.initials: S
authors.lastname: Nonomura
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Gen
authors.initials: G
authors.lastname: Miura
authors.forename: Akihiro
authors.initials: A
authors.lastname: Chiba
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D001766:Blindness / Q000139:chemically induced; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D007049:Iatrogenic Disease; D007267:Injections; D009666:Nose; D009880:Ophthalmic Artery / Q000187:drug effects*; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid