title: Efficient one-pot synthesis of peapod-like hollow carbon nanomaterials for utrahigh drug loading capacity.
abstract: In this paper, peapod-like hollow carbon nanomaterial was fabricated via an efficient one-pot hydrothermal route. The carbon-silica composite was employed as the precursor and cetyltrimethylammonium bromide (CTAB) as the morphology-controlled agent. SEM and TEM results indicated that the carbon shell and the silica core in the precursor were not closely linked but rattle-type structure. After removing the silica template, the obtained carbon product had uniform peapod-like morphology, interconnected pores and high specific surface areas (above 800.0 m(2)/g). We found that CTAB played an important role in the formation of the products with peapod-like morphology. The particle sizes of the hollow carbon nanospheres were readily adjusted by varying the dosage of tetraethoxysilane (TEOS) and the volume ratio of ethanol and water. Based on the experimental results, the formation mechanism of the hollow carbon nanomaterial was also discussed. By virtue of their unique nanostructure and porous properties, the peapod-like hollow carbon nanomaterial exhibited ultrahigh drug loading capacity above 98.4% for doxorubicin hydrochloride (DOX).
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Jingxin
authors.initials: J
authors.lastname: Guo
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, PR China. Electronic address: hjzhang128@shu.edu.cn.
authors.forename: Haijiao
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Hongya
authors.initials: H
authors.lastname: Geng
authors.affiliation: Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, PR China.
authors.forename: Xianqiang
authors.initials: X
authors.lastname: Mi
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China.
authors.forename: Guoji
authors.initials: G
authors.lastname: Ding
authors.affiliation: Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, PR China. Electronic address: zjiao@shu.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiao
mesh_terms: D002244:Carbon / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D033362:Powder Diffraction
chemical_list: D004364:Pharmaceutical Preparations; D002244:Carbon
keywords: Drug loading; Formation mechanism; Hollow carbon nanomaterials; Hydrothermal synthesis; Peapod-like