title: [Expression and clinicopathological significance of Emi1 in breast carcinoma].
abstract: OBJECTIVE
  To examine the expression and prognostic value of novel oncogene Emi1 in breast cancer.
  
  
  METHODS
  Immunohistochemical analysis was performed for 93 human breast carcinoma samples and adjacent normal tissues for detecting the expression of Emi1 and cell proliferative factor Ki-67. Then the data were correlated with clinicopathological features.
  
  
  RESULTS
  Emi1 was highly expressed in breast carcinoma tissues compared with adjacent normal tissues. Emi1 expression was significantly associated with histological grade (P = 0.002) , axillary lymph node status (P = 0.017) and ER status (P = 0.038) . However, there was no correlation between Emi1 expression and other factors such as age, tumor size, histology, PR status, HER-2 or P53. Meanwhile similar results were obtained for Ki-67 expression. A marked correlation also existed between Emi1 and Ki-67 expression (Spearman's r² = 0.454, P = 0.002) .
  
  
  CONCLUSIONS
  As a novel breast cancer associated gene, Emil plays an important role in evaluating invasion and metastatic potentiality in breast cancer. And it is also an important prognostic predictor of breast cancer so as to become a potential therapeutic target for breast cancer.
authors.affiliation: Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China.
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China. Email: nqc.user@163.com.
authors.forename: Qichao
authors.initials: Q
authors.lastname: Ni
authors.affiliation: Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China.
authors.forename: Chenyi
authors.initials: C
authors.lastname: Sheng
authors.affiliation: Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of General Surgery, Affiliated Hospital, Nantong University, Nantong 226001, China.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Wang
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D044783:F-Box Proteins / Q000378:metabolism*; D006801:Humans; D019394:Ki-67 Antigen; D008198:Lymph Nodes; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases
chemical_list: D018797:Cell Cycle Proteins; D044783:F-Box Proteins; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; C498960:FBXO5 protein, human