title: Fructose- and glucose-conditioned preferences in FVB mice: strain differences in post-oral sugar appetition.
abstract: Recent studies indicate that, unlike glucose, fructose has little or no post-oral preference conditioning actions in C57BL/6J (B6) mice. The present study determined whether this is also the case for FVB mice, which overconsume fructose relative to B6 mice. In experiment 1, FVB mice strongly preferred a noncaloric 0.1% sucralose + 0.1% saccharin (S+S) solution to 8% fructose in a 2-day choice test but switched their preference to fructose after separate experience with the two sweeteners. Other FVB mice displayed a stronger preference for 8% glucose over S+S. In a second experiment, ad libitum-fed FVB mice trained 24 h/day acquired a significant preference for a flavor (CS+) paired with intragastric (IG) self-infusions of 16% fructose over a different flavor (CS-) paired with IG water infusions. IG fructose infusions also conditioned flavor preferences in food-restricted FVB mice trained 1 h/day. IG infusions of 16% glucose conditioned stronger preferences in FVB mice trained 24- or 1 h/day. Thus, fructose has post-oral flavor conditioning effects in FVB mice, but these effects are less pronounced than those produced by glucose. Further studies of the differential post-oral conditioning effects of fructose and glucose in B6 and FVB mice should enhance our understanding of the physiological processes involved in sugar reward.
authors.affiliation: Brooklyn College and the Graduate School, City University of New York, Brooklyn, New York asclafani@gc.cuny.edu.
authors.forename: Anthony
authors.initials: A
authors.lastname: Sclafani
authors.affiliation: Brooklyn College and the Graduate School, City University of New York, Brooklyn, New York.
authors.forename: Steven
authors.initials: S
authors.lastname: Zukerman
authors.affiliation: Brooklyn College and the Graduate School, City University of New York, Brooklyn, New York.
authors.forename: Karen
authors.initials: K
authors.lastname: Ackroff
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005518:Food Preferences / Q000187:drug effects*; D005632:Fructose / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D012201:Reward; D012439:Saccharin / Q000008:administration & dosage; D013045:Species Specificity; D013395:Sucrose / Q000008:administration & dosage / Q000031:analogs & derivatives; D013549:Sweetening Agents / Q000008:administration & dosage; D055697:Taste Perception / Q000187:drug effects*; D013997:Time Factors
chemical_list: D004040:Dietary Carbohydrates; D013549:Sweetening Agents; D005632:Fructose; D013395:Sucrose; C026285:trichlorosucrose; D012439:Saccharin; D005947:Glucose
keywords: C57BL/6J mice; post-oral flavor conditioning; saccharin; sucralose