title: Relationship between dietary intake and use of protease inhibitors with anthropometric and biochemical parameters of lipodystrophy in people living with hiv.
abstract: The lipodystrophy syndrome is characterized by redistribution of body fat and disorders of glicidic and lipid metabolism. Although its etiology is related to infection and drug therapy, there is little evidence regarding the nutritional disturbances on this association. This study aimed to assess the relationship between dietary intake and use of protease inhibitors (PIs) with anthropometric and biochemical parameters in HIV positive patients. The study included 50 patients. A questionnaire about socioeconomic status, lifestyle and infection history was taken. In addition, it was conducted the evaluation of dietary intake (frequency questionnaire), anthropometric parameters (body mass index, waist circumference, triceps skinfold, corrected arm muscle area) and biochemistry tests (glycemia and lipid profile). Only 37% of the sample was classified as "good food consumption", 54% were overweight or obese and 66% presented high waist circumference. The group with good food consumption had higher HDL-C (p=0.04) levels than the group with poor food consumption. Patients taking PIs presented VLDL-C (p=0.023) and triglycerides (p=0.024) levels significantly higher. These results indicated the necessity for continuous monitoring of HIV-positive patients and non-pharmacological interventions such as nutrition education and practice of physical exercises.
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil.. tatianeandreza@yahoo.com.br.
authors.forename: Tatiane Andreza Lima
authors.initials: TA
authors.lastname: da Silva
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil..
authors.forename: Renata Rangel
authors.initials: RR
authors.lastname: Barboza
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil..
authors.forename: Ricardo Dias
authors.initials: RD
authors.lastname: de Andrade
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil..
authors.forename: Rafaela Catherine da Silva Cunha
authors.initials: RC
authors.lastname: de Medeiros
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil..
authors.forename: Jason Azevedo
authors.initials: JA
authors.lastname: de Medeiros
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil..
authors.forename: Hunaway Albuquerque Galvão
authors.initials: HA
authors.lastname: de Souza
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil..
authors.forename: Lúcia Dantas
authors.initials: LD
authors.lastname: Leite
authors.affiliation: Federal University of Rio Grande do Norte, Natal. Brazil. Research Group Atividade Física e Saúde - AFISA. Brazil..
authors.forename: Paulo Moreira Silva
authors.initials: PM
authors.lastname: Dantas
mesh_terms: D001837:Body Weights and Measures; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism*; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011480:Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D011480:Protease Inhibitors