title: [Research advances on anti-ANGPT2 antibody in acute myeloid leukemia].
abstract: Angiopoietin2( ANGPT2 ) plays an important role in tumor angiopoiesis. ANGPT2 antagonises ANGPT1 resulting in an effect on the stability of blood vessels, which promotes tumor growth, invasion, proliferation as well as relating to tumor vascular density. A lot of researches published papers about anti-ANGPT2 for the treatment of tumor, and have made some progresses. In this review, the role of ANGPT2 in the pathogenesis of acute myelogenous leukemia (AML), including its effects on proliferation of leukemia cells, bone marrow angiopoiesis, tumor invasion and metastasis are briefly summarised in order to provide the basis for targeted ANGPT2 in treatment of AML.
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan Province, China.
authors.forename: Yan-Wei
authors.initials: YW
authors.lastname: Chen
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Mou
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan Province, China.
authors.forename: Song-Lan
authors.initials: SL
authors.lastname: Yang
authors.affiliation: Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650500, Yunnan Province, China. E-mail: youzhangmd@ailyun.com.
authors.forename: You
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D042683:Angiopoietin-1 / Q000276:immunology*; D000906:Antibodies / Q000276:immunology*; D001853:Bone Marrow; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology*; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
chemical_list: C467630:ANGPT1 protein, human; D042683:Angiopoietin-1; D000906:Antibodies