title: SFTS virus infection in nonhuman primates.
abstract: SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible to SFTSV infection, but the infection in nonhuman primates has not been investigated. This study is the first to report that, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases and myocardial enzymes in blood. Viremia, virus-specific immunoglobulin M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all infected macaques. Levels of the cytokines interferon γ, eotaxin, tumor necrosis factor α, and macrophage inflammatory protein 1β were significantly elevated in the blood. Minor pathological lesions were observed in the liver and kidney during the late stages of infection. Overall, SFTSV infection in rhesus macaques resembled mild SFTS in humans.
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Cong
authors.initials: C
authors.lastname: Jin
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Mifang
authors.initials: M
authors.lastname: Liang
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC Wenzhou Medical University, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Wen
authors.initials: W
authors.lastname: Gu
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Fushun
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Ting
authors.initials: T
authors.lastname: Chen
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Weilun
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Quanfu
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Laboratory of Virus, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing.
authors.forename: Chuan
authors.initials: C
authors.lastname: Qin
authors.affiliation: Key Laboratory for Medical Virology, NHFPC, National Institute for Viral Disease Control and Prevention, China CDC.
authors.forename: Dexin
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002044:Bunyaviridae Infections / Q000097:blood / Q000276:immunology / Q000662:veterinary*; D016207:Cytokines / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000821:virology; D008099:Liver / Q000473:pathology / Q000821:virology; D008253:Macaca mulatta / Q000276:immunology / Q000821:virology*; D051379:Mice; D008992:Monkey Diseases / Q000097:blood / Q000276:immunology / Q000821:virology*; D016856:Phlebovirus / Q000276:immunology*; D012367:RNA, Viral / Q000097:blood
chemical_list: D000914:Antibodies, Viral; D016207:Cytokines; D012367:RNA, Viral
keywords: SFTS virus; infectious animal model; nonhuman primate; pathogenesis