title: The comparative study of Yaz and Ovocept-ld on patients with simple ovarian cysts referring to Iran-Isfahan Shariati Hospital.
abstract: BACKGROUND
  Functional ovarian cysts include follicular, corpus luteum, and theca lutein cysts are the most common adnexal masses (about 50%) in women of reproductive age. Treatment with the combined monophasic oral contraceptives reduces functional ovarian cysts. Yaz (drospirenone/ethinyl estradiol) is a low-dose combined oral contraceptive pill containing 20 μg ethinyl estradiol and 3 mg drospirenone. In addition to contraceptive effects, Yaz has anti-mineralocorticoid and anti-adrenergic effects. Ovocept- low-dose LD is also a low-dose combined oral contraceptive drug containing 30 μg ethinyl estradiol and 3 mg norgestrol. Ovocept-LD has some side-effects such as weight gain, spotting, breast tenderness, nausea, and headache.
  
  
  METHODS
  Being a clinical study, the present research was carried out on 42 patients with the simple ovarian cysts from 2010 to 2012. 84 Patients were assigned to A and B groups. Group A received Yaz once a day for a period of 28 days and group B received Ovocept-LD once a day for a period of 21 days. After treating by Yaz and Ovocept-LD, Cysts were evaluated by ultrasound. Results were analyzed by the SPSS software. A P < 0.05 was considered the significance threshold.
  
  
  RESULTS
  Obtained results indicated that both Yaz and Ovocept-LD had an effect on the simple ovarian cysts. Statistical tests, however, has shown that the effect of Yaz has been significantly more than that of Ovocept-LD.
  
  
  CONCLUSIONS
  Given the faster and better recovery effect, and the lesser side effects of Yaz as compared to Ovocept-LD, it is recommended to use Yaz for the simple ovarian cysts.
authors.affiliation: Department of Medical Sciences, Nursing and Midwifery College, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
authors.forename: Soheyla
authors.initials: S
authors.lastname: Riahinejad
authors.affiliation: Department of Medical Sciences, Nursing and Midwifery College, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
authors.forename: Azam Foroughi
authors.initials: AF
authors.lastname: Pour
authors.affiliation: Department of Medical Sciences, Nursing and Midwifery College, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Dehghani
authors.affiliation: Faculty of Midwifery Group, Nursing and Midwifery College, Islamic Azad University, Najafabad Branch, Isfahan, Iran.
authors.forename: Saadat
authors.initials: S
authors.lastname: Hajizadeh
keywords: Ovocept-LD; Yaz; simple ovarian cyst