title: Receptor conversion in carcinoma breast metastatic to the bone marrow.
abstract: Breast cancer is the first in the incidence of malignancies among women. The documented frequency of osseous metastasis from breast cancer is about 12.8 %. Although breast cancer cells have been documented in the bone marrow in autopsy, haematological manifestations due to metastatic disease to the marrow is rare. The prognosis of these cases is dismal and improper management worsen the condition further. IHC for ER, PR & Her 2/neu status plays a vital role in ascertaining the treatment protocol both in primary tumors as well as metastatic or recurrent tumors. Receptor conversion has been documented in metastatic and recurrent cases. We report a case of 65 year female with a history of ER, PR positive and Her 2/neu negative carcinoma breast 3½ years back, presented with anemia and low back ache diagnosed as metastatic breast carcinoma to bone marrow with receptor conversion.
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: T
authors.initials: T
authors.lastname: Santosh
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: M K
authors.initials: MK
authors.lastname: Patro
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: J
authors.initials: J
authors.lastname: Nayak
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: A K
authors.initials: AK
authors.lastname: Bal
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: A
authors.initials: A
authors.lastname: Choudhury
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: B
authors.initials: B
authors.lastname: Behera
authors.affiliation: Department of Pathology, MKCG Medical College, Brahmapur, Odisha 760004 India.
authors.forename: D P
authors.initials: DP
authors.lastname: Mishra
keywords: Immunohistochemistry; Metastatic breast carcinoma; Receptor Conversion