title: Different effect of oral cyclosporine therapy and oral antihistamine therapy on serum high-sensitivity C-reactive protein level and thymus and activation-regulated chemokine level in atopic dermatitis in older children and adulthood.
abstract: BACKGROUND
  Many patients with atopic dermatitis (AD) are treated with oral cyclosporine or antihistamine therapy in clinical practice.
  
  
  OBJECTIVE
  To evaluate the effectiveness of oral cyclosporine and antihistamine therapy on clinical and laboratory findings in patients with AD.
  
  
  METHODS
  Twenty-five patients with AD (male-female = 11 : 14, age 16-42 years old, mean 26.2 years old) were treated with oral cyclosporine therapy. Twenty-three patients with AD (male-female = 10 : 13, age 15-32 years old, mean 24.2 years old) were treated with oral antihistamine therapy. Laboratory findings including high-sensitivity C-reactive protein (CRP) and thymus and activation-regulated chemokine (TARC) were statistically studied.
  
  
  RESULTS
  Serum TARC level after oral cyclosporine therapy (1013 ± 883 pg/ml) was significantly decreased compared to before therapy (38 194 ± 4678 pg/ml; P < 0.02). Basophil counts in peripheral blood after the therapy (49.7 ± 26.4 × 10(-3) cells/μl) were more significantly increased than before therapy (41.1 ± 16.7 × 10(-3) cells/μl; P < 0.05). Serum high-sensitivity CRP level after antihistamine therapy (0.09 ± 0.08 mg/ml) was significantly decreased compared to before therapy (0.13 ± 0.12 mg/ml; P < 0.05). Basophil counts in peripheral blood after the therapy (33.4 ± 16.2 × 10(-3) cells/μl) were more significantly decreased than before therapy (41.5 ± 23.3 × 10(-3) cells/μl; P < 0.01).
  
  
  CONCLUSIONS
  Different effects of oral cyclosporine therapy and oral antihistamine therapy to serum high-sensitivity CRP level, TARC level, and peripheral blood basophils in adult patients with AD were shown. A combination of these two therapies may be more effective for the treatment of AD in adults.
authors.affiliation: Department of Dermatology, International University of Health and Welfare Hospital, Nasushiobara, Tochigi, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ohtsuka
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis* / Q000187:drug effects*; D054414:Chemokine CCL17 / Q000097:blood* / Q000187:drug effects*; D016572:Cyclosporine / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000097:blood* / Q000188:drug therapy*; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D054414:Chemokine CCL17; D006633:Histamine Antagonists; D016572:Cyclosporine; D002097:C-Reactive Protein