title: Drug persistency of cholinesterase inhibitors for patients with dementia of Alzheimer type in Korea.
abstract: This study examined 1-year persistency with cholinesterase inhibitors (ChEIs) for the treatment of elderly Alzheimer's dementia (AD) patients in Korea. Korean Health Insurance Review & Assessment Service database from January 2005 to June 2006 was used. Patients aged 65 or older with AD diagnosis who were first prescribed a ChEI were included. The 1-year persistence, persistency rate, and switching patterns during the follow-up period were identified. Mean time to drug discontinuation was analyzed, and persistency rates between different patient factors were compared. The 1-year persistency rate of newly treated 6,461 AD patients was 24.0%, while 50% of study patients discontinued treatment by 91 days from initiation. Persistency rates of female patients (22.8%), patients in rural areas (12.7%), and primary care (10.2%) were relatively low (p < 0.001). Persistency rate differed between age groups (p < 0.001). Overall proportion of switching was 6.6%. The 1-year persistency rate of ChEIs for AD patients in Korea did not reach those of previous researches in other countries. Patients less likely to remain on therapy should be especially monitored to optimize treatment persistence.
authors.affiliation: Korea Institute of Drug Safety and Risk Management, Seoul, Korea.
authors.forename: So-Hyeon
authors.initials: SH
authors.lastname: Ahn
authors.forename: Nam-Kyong
authors.initials: NK
authors.lastname: Choi
authors.forename: Ye-Jee
authors.initials: YJ
authors.lastname: Kim
authors.forename: Jong-Mi
authors.initials: JM
authors.lastname: Seong
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Shin
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Jung
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Park
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000453:epidemiology; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D017891:Pharmacoepidemiology; D011320:Primary Health Care / Q000706:statistics & numerical data; D056910:Republic of Korea / Q000453:epidemiology; D012424:Rural Population; D012737:Sex Factors; D016019:Survival Analysis; D014505:Urban Population; D016903:Drug Monitoring
chemical_list: D002800:Cholinesterase Inhibitors