title: Type 2 diabetes seems not to be a risk factor for the carpal tunnel syndrome: a case control study.
abstract: BACKGROUND
  Previous studies have shown that the carpal tunnel syndrome seems to occur more frequently in patients with diabetes mellitus and might be associated with the duration of diabetes mellitus, microvascular complications and degree of glycaemic control. Primary aim was to determine if type 2 diabetes can be identified as a risk factor for carpal tunnel syndrome after adjusting for possible confounders. Furthermore, the influence of duration of diabetes mellitus, microvascular complications and glycaemic control on the development of carpal tunnel syndrome was investigated.
  
  
  METHODS
  Retrospective, case-control study using data from electronic patient charts from the Isala (Zwolle, the Netherlands). All patients diagnosed with carpal tunnel syndrome in the period from January 2011 to July 2012 were included and compared with a control group of herniated nucleus pulposus patients.
  
  
  RESULTS
  A total of 997 patients with carpal tunnel syndrome and 594 controls were included. Prevalence of type 2 diabetes was 11.5% in the carpal tunnel syndrome group versus 7.2% in the control group (Odds Ratio 1.67 (95% confidence interval 1.16-2.41)). In multivariate analyses adjusting for gender, age and body mass index, type 2 diabetes was not associated with carpal tunnel syndrome (OR 0.99 (95% CI 0.66-1.47)). No differences in duration of diabetes mellitus, microvascular complications or glycaemic control between groups were detected.
  
  
  CONCLUSIONS
  Although type 2 diabetes was more frequently diagnosed among patients with carpal tunnel syndrome, it could not be identified as an independent risk factor.
authors.affiliation: Diabetes Centre, Isala, Zwolle, the Netherlands. s.hendriks@isala.nl.
authors.forename: Steven H
authors.initials: SH
authors.lastname: Hendriks
authors.forename: Peter R
authors.initials: PR
authors.lastname: van Dijk
authors.forename: Klaas H
authors.initials: KH
authors.lastname: Groenier
authors.forename: Peter
authors.initials: P
authors.lastname: Houpt
authors.forename: Henk J G
authors.initials: HJ
authors.lastname: Bilo
authors.forename: Nanne
authors.initials: N
authors.lastname: Kleefstra
mesh_terms: D000328:Adult; D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors