title: Lung involvement in systemic sclerosis: role of high resolution computed tomography and its relationship with other pulmonary and clinico-serological features.
abstract: The study investigated the characteristic of interstitial lung disease in a large series of systemic sclerosis (SSc) patients by means of HRCT and the correlations between functional lung parameters, serological features and the extent of lung involvement evaluated by high-resolution computed tomography (HRCT). One hundred and seven SSc patients, consecutively investigated by means of HRCT, standard chest X-ray, and pulmonary function tests, were retrospectively evaluated. Chest radiogram and HRCT scores were strongly associated (Pearson's r=0.82, p < .0001); moreover, the first significantly correlated with spirometric parameters, even if weakly. Anti-Scl70 and anti-centromere antibodies were associated with higher (p=0.01) and lower HRCT score (p=0.0002), respectively. The extension of interstitial lung involvement in SSc evaluated with HRCT is directly proportional to functional lung parameters. HRCT, spirometry and DLco should be considered essential in the core-set of non-invasive diagnostic tools for the first-line assessment of scleroderma lung involvement.
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena;
authors.forename: M
authors.initials: M
authors.lastname: Colaci
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena;
authors.forename: M
authors.initials: M
authors.lastname: Sebastiani
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena;
authors.forename: A
authors.initials: A
authors.lastname: Manfredi
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena;
authors.forename: D
authors.initials: D
authors.lastname: Giuggioli
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena.
authors.forename: G
authors.initials: G
authors.lastname: Cassone
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena.
authors.forename: C U
authors.initials: CU
authors.lastname: Manzini
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena.
authors.forename: C
authors.initials: C
authors.lastname: Ghizzoni
authors.affiliation: Center for Rare Lung Diseases, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Cerri
authors.affiliation: Rheumatology Unit, Department of Medical and Surgical Science for Adults and Children, University of Modena and Reggio Emilia, Modena.
authors.forename: C
authors.initials: C
authors.lastname: Ferri
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000097:blood / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012595:Scleroderma, Systemic / Q000097:blood / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D000974:Antibodies, Antinuclear