title: Primary clear cell ductal adenocarcinoma of the pancreas: a case report and clinicopathologic literature review.
abstract: We present a very rare, interesting case of a carcinoma of the pancreas with predominantly abundant clear cell morphology. According to the WHO classification, primary clear cell carcinoma of the pancreas is classified as a rare "miscellaneous" carcinoma. The tumor was observed in the distal body and tail of the pancreas of a 74-year-old woman. The histopathology of tumor cells showed well-defined cell membranes, clear cytoplasm, and prominent cell boundaries. Immunohistochemical (IHC) staining showed positive reactions to antibodies against vimentin, cytokeratin 7 (CK-7), mucicarmine (MUC-1), periodic acid-Schiff (PAS), periodic acid-Schiff with diastase (PASD), carcinoembryonic antigen (CEA), and Carbohydrate Antigen 19-9 (CA 19-9). On the other hand, IHC staining was negative for alpha-fetoprotein (AFP), cytokeratin 20 (CK-20), HMB45, chromogranin, and synaptophysin. The patient was subsequently diagnosed with a primary solid-type pancreatic clear cell carcinoma with hepatic metastasis. Herein, we report this rare case and include a review of the current literature of this tumor.
authors.forename: Yashpal
authors.initials: Y
authors.lastname: Modi
authors.affiliation: Department of Pathology, Hematology and Oncology, St Michael's Medical Center, Newark, NJ, USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Shaaban
authors.forename: Dron
authors.initials: D
authors.lastname: Gauchan
authors.forename: Michael
authors.initials: M
authors.lastname: Maroules
authors.forename: Nalini
authors.initials: N
authors.lastname: Parikh
authors.forename: Gunwant
authors.initials: G
authors.lastname: Guron
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers