title: O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?
abstract: O-GlcNAc signaling is regulated by an opposing pair of enzymes: O-GlcNAc transferase installs and O-GlcNAcase (OGA) removes the modification from proteins. The dynamics and regulation of this process are only beginning to be understood as the physiological functions of both enzymes are being probed using genetic and pharmacological approaches. This minireview charts the discovery and functional and structural analysis of OGA and summarizes the insights gained from recent studies using OGA inhibition, gene knock-out, and overexpression. We identify several areas of "known unknowns" that would benefit from future research, such as the enigmatic C-terminal domain of OGA.
authors.affiliation: From the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and.
authors.forename: Jana
authors.initials: J
authors.lastname: Alonso
authors.affiliation: From the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and.
authors.forename: Marianne
authors.initials: M
authors.lastname: Schimpl
authors.affiliation: From the Medical Research Council Protein Phosphorylation and Ubiquitylation Unit and Division of Molecular Microbiology, College of Life Sciences, University of Dundee, DD1 5EH Dundee, Scotland, United Kingdom dmfvanaalten@dundee.ac.uk.
authors.forename: Daan M F
authors.initials: DM
authors.lastname: van Aalten
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D015398:Signal Transduction; D013379:Substrate Specificity; D001619:beta-N-Acetylhexosaminidases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D004791:Enzyme Inhibitors; C110628:hexosaminidase C; D001619:beta-N-Acetylhexosaminidases; D000117:Acetylglucosamine
keywords: Cell Signaling; Enzyme Inhibitor; Epigenetics; Genetics; Glycobiology; Protein Structure