title: Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan.
abstract: Around 2 billion people worldwide are infected with the apicomplexan parasite Toxoplasma gondii which induces a variety of medical conditions. For example, primary infection during pregnancy can result in fetal death or mental retardation of the child. Diagnosis of acute infections in pregnant women is challenging but crucially important as the drugs used to treat T. gondii infections are potentially harmful to the unborn child. Better, faster, more reliable, and cheaper means of diagnosis by using defined antigens for accurate serological tests are highly desirable. Synthetic pathogen-specific glycosylphosphatidylinositol (GPI) glycan antigens are diagnostic markers and have been used to distinguish between toxoplasmosis disease states using human sera.
authors.affiliation: Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam (Germany); Institute of Chemistry and Biochemistry, Freie Universität Berlin, Arnimallee 22, 14195 Berlin (Germany).
authors.forename: Sebastian
authors.initials: S
authors.lastname: Götze
authors.forename: Nahid
authors.initials: N
authors.lastname: Azzouz
authors.forename: Yu-Hsuan
authors.initials: YH
authors.lastname: Tsai
authors.forename: Uwe
authors.initials: U
authors.lastname: Groß
authors.forename: Anika
authors.initials: A
authors.lastname: Reinhardt
authors.forename: Chakkumkal
authors.initials: C
authors.lastname: Anish
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
authors.forename: Daniel
authors.initials: D
authors.lastname: Varón Silva
mesh_terms: D002240:Carbohydrate Sequence; D017261:Glycosylphosphatidylinositols / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry*; D014123:Toxoplasmosis / Q000175:diagnosis*
chemical_list: D017261:Glycosylphosphatidylinositols; D011134:Polysaccharides
keywords: biomarkers; carbohydrate microarrays; medicinal chemistry; toxoplasmosis