title: Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols.
abstract: A library of 41 aryloxyimino amides was prepared via solution phase parallel synthesis by extending the multicomponent reaction of (Z)-chlorooximes and isocyanides to the use of electron-deficient phenols. The resulting aryloxyiminoamide derivatives can be used as intermediates for the synthesis of benzo[d]isoxazole-3-carboxamides, dramatically reducing the number of synthetic steps required by other methods reported in literature.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale "A. Avogadro" , Largo Donegani 2, 28100 Novara, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Mercalli
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Giustiniano
authors.forename: Erika
authors.initials: E
authors.lastname: Del Grosso
authors.forename: Monica
authors.initials: M
authors.lastname: Varese
authors.forename: Hilde
authors.initials: H
authors.lastname: Cassese
authors.forename: Alberto
authors.initials: A
authors.lastname: Massarotti
authors.forename: Ettore
authors.initials: E
authors.lastname: Novellino
authors.forename: Gian Cesare
authors.initials: GC
authors.lastname: Tron
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D054879:Halogenation; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry*; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000577:Amides; D003486:Cyanides; D006841:Hydrocarbons, Aromatic; D010091:Oximes; D010636:Phenols
keywords: (Z)-chlorooximes; aryloxyiminoamides; benzo[d]isoxazole-3-carboxamides; isocyanides; multicomponent reactions