title: Effects of High-Protein Diet and/or Resveratrol Supplementation on the Immune Response of Irradiated Rats.
abstract: We investigated the effects of a high-protein diet and resveratrol supplementation on immune cells changes induced by abdominal irradiation in rats. Female Wistar rats were divided into 5 groups: 1) control diet, 2) control diet with irradiation 3) 30% high-protein diet with irradiation, 4) normal diet with resveratrol supplementation and irradiation, and 5) 30% high-protein diet with resveratrol supplementation and irradiation. We measured blood protein and albumin concentrations, lipid profiles, white blood cell (WBC) counts, proinflammatory cytokine production, and splenocyte proliferation in rats that had been treated with a 17.5 Gy dose of radiation 30 days prior. A high-protein diet affected plasma total cholesterol and very low density lipoprotein-cholesterol levels, which were increased by the radiation treatment. In addition, the lymphocyte percentage and immunoglobulin M (IgM) concentration were increased, and the neutrophil percentage was decreased in rats fed a high-protein diet. Resveratrol supplementation decreased the triglyceride (TG) level, but increased the IgM concentration and splenocyte proliferation. Proinflammatory cytokine production was lower in rats fed a high-protein diet supplemented with resveratrol than in rats fed a control diet. The results of the present study indicate that high-protein diets, with or without resveratrol supplementation, might assist with recovery from radiation-induced inflammation by modulating immune cell percentages and cytokine production.
authors.affiliation: Division of Food and Nutritional Science & Life Systems, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Kyoung Ok
authors.initials: KO
authors.lastname: Kim
authors.affiliation: ICAN Nutrition Education and Research, Seoul 150-877, Korea.
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
authors.affiliation: Division of Food and Nutritional Science & Life Systems, Sookmyung Women's University, Seoul 140-742, Korea ; Major in Food and Nutrition, College of Human Ecology, Sookmyung Women's University, Seoul 140-742, Korea.
authors.forename: Hyun-Sook
authors.initials: HS
authors.lastname: Kim
keywords: high-protein diet; immune function; inflammation; radiation treatment; resveratrol