title: NT-proBNP plays an important role in the effect of ibuprofen on preterm infants with patent ductus arteriosus.
abstract: OBJECTIVE
  The aim of this study was to clarify the role of N-terminal pro-brain natriuretic peptide, (NT-proBNP) in ibuprofen on preterm infants with patent ductus arteriosus (PDA).
  
  
  METHODS
  Preterm infants with PDA were enrolled in the present study. Patients were randomized into two groups: ibuprofen group received oral ibuprofen 10 mg/kg, followed by 5 mg/kg after 24 and 48 h, and the placebo group received the same volume of 5% glucose. PDA and NT-proBNP were detected during 24 hours, 3 and 7 days of age.
  
  
  RESULTS
  The results indicated that babies who received oral ibuprofen had higher PDA closure at 7 days after treatment (p < 0.05). Significantly decrease of NT-proBNP was found in ibuprofen group than the placebo group at 3 and 7 days (all p < 0.05).
  
  
  CONCLUSIONS
  Collectively, the favorable effects of ibuprofen on PDA in premature infants maybe mediated in part by the reduction of NT-proBNP level.
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Jinan, PR China. hanbo35@163.com.
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Ding
authors.forename: B
authors.initials: B
authors.lastname: Han
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Zhu
mesh_terms: D004374:Ductus Arteriosus, Patent / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007234:Infant, Premature; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000235:genetics* / Q000378:metabolism*; D010446:Peptide Fragments / Q000235:genetics* / Q000378:metabolism*
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D007052:Ibuprofen