title: The Kalirin Gene rs9289231 Polymorphism as a Novel Predisposing Marker for Coronary Artery Disease.
abstract: BACKGROUND
  Atherosclerosis is the leading cause of death and disability worldwide. Genetic variations play a major role in the process of atherosclerosis. Recently, rs9289231 genetic variations of the Kalirin gene (KALRN) on chromosome 3q21.2 have been introduced as potential genetic markers for coronary artery disease (CAD).
  
  
  OBJECTIVE
  In this case-control study, we investigated the association between genetic susceptibility to CAD and rs9289231 G/T polymorphism, located on the KALRN gene, in an Iranian population.
  
  
  METHODS
  Our cohort consisted of 1486 individuals undergoing coronary angiography. Of these, we considered the 1007 patients with CAD to be case individuals and the 479 individuals with normal coronary conditions to be control individuals. We performed single-nucleotide polymorphism (SNP) genotyping via the high resolution melting (HRM) technique.
  
  
  RESULTS
  Our data showed that the minor allele (G) frequency of rs9289231 SNP was higher in our CAD group than that in our control group (odds ratio, 1:37; confidence interval, 1.07-1.74; P = .01). The results of our data analysis highlighted a genetic association between rs9289231 polymorphism and severity and development of CAD.
  
  
  CONCLUSIONS
  We consider the GG genotype and the G allele of rs9289231 polymorphism of KALRN to be genetic risk factors for CAD in an Iranian population, especially in early-stage atherosclerotic vascular disease.
authors.affiliation: Department of Pathology and Laboratory Medicine and Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammadali
authors.initials: M
authors.lastname: Boroumand
authors.affiliation: Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shayan
authors.initials: S
authors.lastname: Ziaee
authors.affiliation: Department of Medical Biotechnology, Tabriz University of Medical Science, Tabriz, Iran zarghamin@yahoo.com.
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Zarghami
authors.affiliation: Department of Pathology and Laboratory Medicine and Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam Sotudeh
authors.initials: MS
authors.lastname: Anvari
authors.affiliation: Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sara
authors.initials: S
authors.lastname: Cheraghi
authors.affiliation: Family Health Research Center, Iranian Petroleum Health Research Institute, Tehran, Iran.
authors.forename: Seyed Hesameddin
authors.initials: SH
authors.lastname: Abbasi
authors.affiliation: Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Arash
authors.initials: A
authors.lastname: Jalali
authors.affiliation: Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Pourgholi
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D020662:Guanine Nucleotide Exchange Factors; C503866:KALRN protein, human; D017346:Protein Serine-Threonine Kinases
keywords: KALRN; coronary artery disease; high resolution melting; rs9289231 polymorphism