title: A finite strain nonlinear human mitral valve model with fluid-structure interaction.
abstract: A computational human mitral valve (MV) model under physiological pressure loading is developed using a hybrid finite element immersed boundary method, which incorporates experimentally-based constitutive laws in a three-dimensional fluid-structure interaction framework. A transversely isotropic material constitutive model is used to characterize the mechanical behaviour of the MV tissue based on recent mechanical tests of healthy human mitral leaflets. Our results show good agreement, in terms of the flow rate and the closing and opening configurations, with measurements from in vivo magnetic resonance images. The stresses in the anterior leaflet are found to be higher than those in the posterior leaflet and are concentrated around the annulus trigons and the belly of the leaflet. The results also show that the chordae play an important role in providing a secondary orifice for the flow when the valve opens. Although there are some discrepancies to be overcome in future work, our simulations show that the developed computational model is promising in mimicking the in vivo MV dynamics and providing important information that are not obtainable by in vivo measurements.
authors.affiliation: School of Mathematics and Statistics, University of Glasgow, Glasgow, UK.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Xingshuang
authors.initials: X
authors.lastname: Ma
authors.forename: Nan
authors.initials: N
authors.lastname: Qi
authors.forename: Colin
authors.initials: C
authors.lastname: Berry
authors.forename: Boyce E
authors.initials: BE
authors.lastname: Griffith
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Luo
mesh_terms: D000328:Adult; D003198:Computer Simulation; D020342:Finite Element Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008943:Mitral Valve / Q000033:anatomy & histology* / Q000502:physiology*; D008955:Models, Cardiovascular; D017711:Nonlinear Dynamics
keywords: clinical imaging; fibre-reinforced constitutive law; finite element immersed boundary method; fluid-structure interaction; human mitral valve; magnetic resonance imaging; nonlinear finite strain