title: Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors.
abstract: Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Berrios
authors.affiliation: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
authors.forename: Joonil
authors.initials: J
authors.lastname: Jung
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA The BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
authors.forename: Blake
authors.initials: B
authors.lastname: Primi
authors.affiliation: Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Pedamallu
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
authors.forename: Fujiko
authors.initials: F
authors.lastname: Duke
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Marcelus
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Jingwei
authors.initials: J
authors.lastname: Cheng
authors.affiliation: Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA The BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
authors.forename: Robert L
authors.initials: RL
authors.lastname: Garcea
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Meyerson
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA james_decaprio@dfci.harvard.edu.
authors.forename: James A
authors.initials: JA
authors.lastname: DeCaprio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000957:Antigens, Viral, Tumor / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D054884:Host-Pathogen Interactions; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011120:Polyomavirus / Q000502:physiology*; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011485:Protein Binding; D017422:Sequence Analysis, DNA; D016036:Seroepidemiologic Studies; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D055815:Young Adult
chemical_list: D000957:Antigens, Viral, Tumor; D004279:DNA, Viral; D025521:Tumor Suppressor Proteins