title: Effect of a novel bioactive glass-ceramic on dentinal tubule occlusion: an in vitro study.
abstract: BACKGROUND
  This in vitro study aimed to assess the ability and efficacy of HX-BGC, a novel bioactive glass-ceramic (SiO2-P2 O5-CaO-Na2 O-SrO), to reduce dentine tubule permeability.
  
  
  METHODS
  Dentine discs from human third molars were etched and randomly allocated into five groups: Group 1--distilled water; Group 2--Sensodyne Repair toothpaste (containing NovaMin®); Group 3--HX-BGC toothpaste (containing 7.5% HX-BGC); Group 4--control toothpaste (without HX-BGC); and Group 5--HX-BGC powder. Specimens were treated daily by brushing with an electric toothbrush for 20 seconds. Between daily treatments (7 days total), specimens were immersed in artificial saliva for 24 hours. Dentine permeability was measured at baseline, after the first treatment, after the first 24-hour immersion in artificial saliva and at the end of day 7. Dentine morphology and surface deposits were observed by scanning electron microscopy after one day and 7 days of treatment, respectively.
  
  
  RESULTS
  Sensodyne Repair and bioactive glass-ceramic toothpaste significantly and immediately lowered dentine permeability. The HX-BGC powder group showed the highest reduction in dentine permeability after 7 days of treatment.
  
  
  CONCLUSIONS
  The novel bioactive glass-ceramic material HX-BGC is effective in reducing dentine permeability by occluding open dentine tubules, indicating that HX-BGC may be a potential treatment for dentine hypersensitivity.
authors.affiliation: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhong
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Yin
authors.forename: T
authors.initials: T
authors.lastname: He
authors.forename: D
authors.initials: D
authors.lastname: Hu
authors.forename: Y
authors.initials: Y
authors.lastname: Liao
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D001672:Biocompatible Materials / Q000494:pharmacology*; D002516:Ceramics / Q000737:chemistry*; D019343:Citric Acid / Q000009:adverse effects; D003460:Crystallization; D003804:Dentin / Q000187:drug effects* / Q000648:ultrastructure; D057133:Dentin Desensitizing Agents / Q000494:pharmacology; D003806:Dentin Permeability / Q000187:drug effects*; D005898:Glass / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D012464:Saliva, Artificial / Q000737:chemistry; D013997:Time Factors; D014077:Tooth Erosion / Q000473:pathology / Q000503:physiopathology; D014099:Toothbrushing / Q000295:instrumentation; D014100:Toothpastes / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D057133:Dentin Desensitizing Agents; C510984:NovaMin; D012464:Saliva, Artificial; D014100:Toothpastes; C558454:bioactive SrO-SiO2 glass; C425330:bioactive glass 45S5; D019343:Citric Acid; C023506:Glass ceramics
keywords: Bioactive glass-ceramic; dentine hypersensitivity; dentine permeability; desensitizing toothpastes; toothbrushing