title: Mapping local orientation of aligned fibrous scatterers for cancerous tissues using backscattering Mueller matrix imaging.
abstract: Polarization measurements are sensitive to the microstructure of tissues and can be used to detect pathological changes. Many tissues contain anisotropic fibrous structures. We obtain the local orientation of aligned fibrous scatterers using different groups of the backscattering Mueller matrix elements. Experiments on concentrically well-aligned silk fibers and unstained human papillary thyroid carcinoma tissues show that the m22 , m33 , m23 , and m32 elements have better contrast but higher degeneracy for the extraction of orientation angles. The m12 and m13 elements show lower contrast, but allow us to determine the orientation angle for the fibrous scatterers along all directions. Moreover, Monte Carlo simulations based on the sphere-cylinder scattering model indicate that the oblique incidence of the illumination beam introduces some errors in the orientation angles obtained by both methods. Mapping the local orientation of anisotropic tissues may not only provide information on pathological changes, but can also give new leads to reduce the orientation dependence of polarization measurements.
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China.
authors.forename: Honghui
authors.initials: H
authors.lastname: He
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, ChinabTsinghua University, Department of Physics, Beijing 100084, China.
authors.forename: Minghao
authors.initials: M
authors.lastname: Sun
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zeng
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, ChinabTsinghua University, Department of Physics, Beijing 100084, China.
authors.forename: E
authors.initials: E
authors.lastname: Du
authors.affiliation: Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Sixth People's Hospital (Nanshan Hospital), Shenzhen 518052, China.
authors.forename: Shaoxiong
authors.initials: S
authors.lastname: Liu
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, ChinabTsinghua University, Department of Physics, Beijing 100084, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: He
authors.affiliation: Tsinghua University, Institute of Optical Imaging and Sensing, Graduate School at Shenzhen, Shenzhen Key Laboratory for Minimal Invasive Medical Technologies, Shenzhen 518055, ChinabTsinghua University, Department of Physics, Beijing 100084, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
mesh_terms: D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology*; D003198:Computer Simulation; D006801:Humans; D008859:Microscopy, Polarization / Q000379:methods*; D008954:Models, Biological; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D047011:Silk / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D047011:Silk