title: Ligand selectivity in stabilising tandem parallel folded G-quadruplex motifs in human telomeric DNA sequences.
abstract: Biophysical studies of ligand interactions with three human telomeric repeat sequences (d(AGGG(TTAGGG)n, n = 3, 7 and 11)) show that an oxazole-based 'click' ligand, which induces parallel folded quadruplexes, preferentially stabilises longer telomeric repeats providing evidence for selectivity in binding at the interface between tandem quadruplex motifs.
authors.affiliation: Centre for Biomolecular Sciences, University Park, University of Nottingham, Nottingham NG7 2RD, UK. mark.searle@nottingham.ac.uk.
authors.forename: Alex R O
authors.initials: AR
authors.lastname: Cousins
authors.forename: Dougal
authors.initials: D
authors.lastname: Ritson
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: Malcolm F G
authors.initials: MF
authors.lastname: Stevens
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
authors.forename: Mark S
authors.initials: MS
authors.lastname: Searle
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D002942:Circular Dichroism; D057930:Click Chemistry; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D010080:Oxazoles / Q000737:chemistry; D016615:Telomere / Q000737:chemistry*
chemical_list: D008024:Ligands; D010080:Oxazoles