title: Superoxide dismutase activity and malondialdehyde levels in patients with travel-induced psychosis.
abstract: BACKGROUND
  Oxidative stress is a neurotoxic factor that may precipitate acute psychoses.
  
  
  OBJECTIVE
  Assess the relationship of travel-induced psychosis and oxidative stress.
  
  
  METHODS
  Twenty-one inpatients with travel-induced psychosis related to prolonged train travel were evaluated using the Brief Psychiatric Rating Scale (BPRS) at the time of admission and their plasma superoxide dismutase (SOD) activity and malondialdehyde (MDA) concentrations were assessed on the morning following admission. These assessments were repeated after the psychotic symptoms resolved, which typically occurred after 2-6 days of low-dose antipsychotic treatment. The SOD and MDA results in the patients were compared to those of 21 normal age and gender matched control subjects.
  
  
  RESULTS
  At admission the patient group had significantly higher SOD activity and MDA concentrations than the control group. After resolution of the psychotic symptoms the BPRS scores, SOD activity, and MDA concentrations all showed significant declines but the SOD activity and MDA concentrations remained higher than in the matched control group. At admission there was a non-significant positive correlation of the BPRS total score with SOD activity (r=0.32, p=0.164) and with MDA concentration (r=0.34, p=0.126). The before versus after drop in the BPRS total score was weakly correlated with the drop in the SOD activity (r=0.28, p=0.217) and with the drop in the MDA concentration (r=0.29, p=0.211).
  
  
  CONCLUSIONS
  These findings suggest that the neurotoxic effects of oxidative stress are directly related to the development of travel-induced psychosis. This may be relevant to the understanding of other acute psychotic states such as schizophrenia.
authors.affiliation: Kunming Mental Hospital, Kunming, Yunnan Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Gong
authors.affiliation: Kunming Mental Hospital, Kunming, Yunnan Province, China.
authors.forename: Ruolian
authors.initials: R
authors.lastname: Zhao
authors.affiliation: Kunming Mental Hospital, Kunming, Yunnan Province, China.
authors.forename: Baochun
authors.initials: B
authors.lastname: Yang