title: [Study on the morphological features, pathologic diagnosis and differential diagnosis of well-differentiated hepatocellular carcinoma].
abstract: OBJECTIVE
  To analyze the clinicopathologic characteristics of well-differentiated hepatocellular carcinoma (WD-HCC), and to find clues for its pathologic diagnosis and differential diagnosis.
  
  
  METHODS
  Seventy-three cases of WD-HCC were studied with clinical data analysis, gross and microscopic examination.
  
  
  RESULTS
  Among the 73 cases, the prevalence of HBV (+) and/or HCV (+) was 94.5% (69/73), liver cirrhosis was 80.8% (59/73), increased hepatic cell density was 95.9% (70/73), dilated and irregular hepatic sinus was 89.0% (65/73), prominent trabecularism was 89.0% (65/73), increased cytoplasmic eosinophilia or basophilia was 90.4% (66/73), glandular-like structure was 16.4% (12/73, and fatty degeneration was 42.4% (31/73) .
  
  
  CONCLUSIONS
  There are important clinicopathologic features associated with WD-HCC. These features are useful in the differential diagnosis of WD-HCC with dysplastic nodule (DN), focal nodular hyperplasia (FNH) and hepatocellular adenoma.
authors.affiliation: Department of Pathology, General Hospital of PLA, Beijing 100853, China. E-mail: weilx301@263.net.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wei
authors.forename: Jingli
authors.initials: J
authors.lastname: Du
authors.forename: Yulan
authors.initials: Y
authors.lastname: Wang
authors.forename: Huaiyin
authors.initials: H
authors.lastname: Shi
authors.forename: Jingmin
authors.initials: J
authors.lastname: Zhao
mesh_terms: D018248:Adenoma, Liver Cell / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000821:virology; D002452:Cell Count; D003937:Diagnosis, Differential; D020518:Focal Nodular Hyperplasia / Q000473:pathology; D016174:Hepacivirus; D006515:Hepatitis B virus; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology* / Q000821:virology