title: Tunable SERS-tags-hidden gold nanorattles for theranosis of cancer cells with single laser beam.
abstract: With the use of gold nanostructures, photothermal therapy (PTT) of cancer has great advantages compared to conventional methods, such as noninvasive targeted destruction and easily operation. Generally speaking, respective diagnosis and therapy of tumor require at least two instruments, leading to incongruence of tumor borders between diagnosis and therapy. To tackle this problem, tunable SERS-tags-hidden gold nanorattles (STHGNRs) have been designed and developed here for theranosis of cancer with single laser beam. The surface plasma resonance peak of STHGNRs can be tuned from visible region to near-infrared region by controlling the cavity size and shell thickness. The outer shells not only improve the stability of the SERS reporters but also enhance the brightness by more than two order magnitude compared to gold nanoparticles. In vitro study, immuno STHGNRs can serve as theranosis agents simultaneously for sensitive and efficient theranosis of cancer cells.
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan, Shandong, China.
authors.forename: Zhaolong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: 1] Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan, Shandong, China [2] Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Dexin
authors.initials: D
authors.lastname: Yu
authors.affiliation: Department of Materials Science and Engineering, Advanced Materials Laboratory, Tsinghua University, Beijing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Materials Science and Engineering, Advanced Materials Laboratory, Tsinghua University, Beijing, China.
authors.forename: Zhengjun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Qilu Hospital of Shandong University, Jinan, Shandong, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Liu
authors.affiliation: Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan, Shandong, China.
authors.forename: Jinhua
authors.initials: J
authors.lastname: Zhan
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy; D013059:Spectrum Analysis, Raman
chemical_list: D006046:Gold