title: Extended Fixed Attribute Dynamics Method and an Illustrative Application in Bio-demographic-genetic Analysis on Longevity.
abstract: This chapter presents and discuss the extended Fixed Attributes Dynamics (FAD) method to estimate the independent effect of a genetic variant (or other fixed attribute) in the absence of another relevant genetic variant (or another relevant fixed attribute), the joint effects when both are present and the effects of interactions between them. We present an illustrative application of the extended FAD method for estimating the general, independent and joint effects of the FOXO genotypes on longevity, based on the genotypic data of 760 centenarians from the Chinese Longitudinal Healthy Longevity Survey, and the 1,060 middle-age controls. We also discuss the strengths and limitations of the FAD method.
authors.affiliation: Center for Study of Aging and Human Development, Medical School of Duke University, Center for Healthy Aging and Development Studies, National School of Development, Peking University. zengyi68@gmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
keywords: Bio-demographic analysis; FOXO genes; Fixed Attributes Dynamics method; G×G and G×E interactions; longevity