title: Change of retinal nerve fiber layer thickness in patients with nonarteritic inflammatory anterior ischemic optic neuropathy.
abstract: In this study, 16 patients (19 eyes) with nonarteritic anterior ischemic optic neuropathy in the acute stage (within 4 weeks) and resolving stage (after 12 weeks) were diagnosed by a series of complete ophthalmic examinations, including fundus examination, optical coherence tomography and fluorescein fundus angiography, and visual field defects were measured with standard automated perimetry. The contralateral uninvolved eyes were used as controls. The retinal nerve fiber layer thickness was determined by optical coherence tomography which showed that the mean retinal nerve fiber layer thickness and the retinal nerve fiber layer thickness from temporal, superior, nasal and inferior quadrants were significantly higher for all measurements in the acute stage than the corresponding normal values. In comparison, the retinal nerve fiber layer thickness from each optic disc quadrant was found to be significantly lower when measured at the resolving stages, than in the control group. Statistical analysis on the correlation between optic disc nerve fiber layer thickness and visual defects demonstrated a positive correlation in the acute stage and a negative correlation in the resolving stage. Our experimental findings indicate that optical coherence tomography is a useful diagnostic method for nonarteritic anterior ischemic optic neuropathy and can be used to evaluate the effect of treatment.
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Bi
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Xingrong
authors.initials: X
authors.lastname: Wang
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Guimin
authors.initials: G
authors.lastname: Wang
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wen
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Chenyang
authors.initials: C
authors.lastname: Cong
authors.affiliation: Eye Institute of Shandong Traditional Chinese Medicine University, Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Ophthalmology Department of Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250001, Shandong Province, China.
authors.forename: Daoguang
authors.initials: D
authors.lastname: Wang
keywords: neural regeneration; nonarteritic anterior ischemic optic neuropathy; optic nerve; optical coherence tomography; peripheral nerve injury; retinal nerve fiber layer; visual field