title: [Comparative study of the effect of S-amlodipine nicotinate and amlodipine benzylate on the arterial pressure of awake rats].
abstract: We have performed a comparative study of the effects of two calcium channel blockers, S-amlodipine nicotinate and amnlodipine benzylate, on the arterial pressure (AP) of awake rats measured in the tail artery. The results of experiments showed that both preparations produce a statistically significant long-term decrease in the AP of animals. In respect of both strength and duration of the hypotensive effect, S-amlodipine nicotinate somewhat exceeds amnlodipine benzylate.
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: G A
authors.initials: GA
authors.lastname: Kim
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: A A
authors.initials: AA
authors.lastname: Gorbunov
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D017311:Amlodipine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D062186:Arterial Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D009525:Niacin / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014851:Wakefulness / Q000502:physiology
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; C519553:amlodipine nicotinate; D017311:Amlodipine; D009525:Niacin