title: The anthraquinone derivatives from the fungus Alternaria sp. XZSBG-1 from the saline lake in Bange, Tibet, China.
abstract: Four new anthraquinone derivatives 1-4 were obtained along with seven known compounds 5-11 from the extracts of the fungal strain Alternaria sp. XZSBG-1 which was isolated from the sediments of the carbonate saline lake in Bange, Tibet, China. Their structures were determined by spectroscopic methods, mainly by 2D NMR spectra. Compound 1 is a novel tetrahydroanthraquinone with an epoxy ether bond between C-4a and C-9a. In the primary bioassays, compound 3 (alterporriol T) exhibited inhibition of a-glucosidase with a IC50 value 7.2 μM, and compound 9 showed good inhibitory activity against the HCT-116 and HeLa cell lines, with IC50 values of 3.03 and 8.09 μM, respectively.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. chenyishan@126.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. cesshq@163.com.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Shen
authors.affiliation: Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, China. zhuxun8@mail.sysu.edu.cn.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. ceslyc@mail.sysu.edu.cn.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000528:Alternaria / Q000737:chemistry / Q000302:isolation & purification*; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D061986:MCF-7 Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D018609:Tibet
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents