title: Quality of life after acute pancreatitis: a systematic review and meta-analysis.
abstract: Patient-centered outcomes, including quality of life (QoL), after acute pancreatitis (AP) remain largely unknown. Our aim was to systematically review the best available evidence on QoL after AP. English-language articles on the effect of AP on QoL were identified in MEDLINE, EMBASE, and Scopus. Results were statistically aggregated to obtain a pooled mean difference (MD) and corresponding 95% confidence interval (CI) for individual QoL domains and component summaries, where appropriate. A total of 16 prospective observational studies encompassing 687 AP patients were included. Four studies comprising 267 AP patients, as measured by SF-36 and SF-12 questionnaires, were suitable for meta-analysis. The general health and vitality domains were significantly worse in the patients compared with healthy controls (MD, -10.90; 95% CI, -15.63 to -6.17; P < 0.00001 and MD, -4.64; 95% CI, -7.32 to -1.95; P = 0.0007, respectively). The remaining individual domains and physical and mental component summary scores did not differ between patients and controls. The QoL seems to be significantly impaired in patients after AP with a need to standardize reporting on QoL. Future studies should investigate the effect of different interventions on patients' QoL.
authors.affiliation: From the Department of Surgery, The University of Auckland, Auckland, New Zealand.
authors.forename: Sayali A
authors.initials: SA
authors.lastname: Pendharkar
authors.forename: Kylie
authors.initials: K
authors.lastname: Salt
authors.forename: Lindsay D
authors.initials: LD
authors.lastname: Plank
authors.forename: John A
authors.initials: JA
authors.lastname: Windsor
authors.forename: Maxim S
authors.initials: MS
authors.lastname: Petrov
mesh_terms: D000203:Activities of Daily Living; D003289:Convalescence; D004644:Emotions; D005500:Follow-Up Studies; D006760:Hospitalization; D006801:Humans; D064887:Observational Studies as Topic; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D010195:Pancreatitis / Q000523:psychology* / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D012107:Research Design; D012919:Social Behavior; D016896:Treatment Outcome