title: Palladium-catalyzed coupling of N-tosylhydrazones and β-bromostyrene derivatives: new approach to 2H-chromenes.
abstract: 2H-Chromene is an important structural motif that exists in natural products and non-natural compounds possessing interesting biological activities. In this investigation, a highly efficient approach toward 2H-chromenes has been developed based on palladium-catalyzed coupling of N-tosylhydrazones and β-bromostyrenes. The mechanism of this reaction is proposed that involves the formation of vinyl palladium by carbene migratory insertion and the intramolecular nucleophilic substitution.
authors.affiliation: College and Chemical Engineering, Qingdao University of Science & Technology, Qingdao 266042, China.
authors.forename: Yamu
authors.initials: Y
authors.lastname: Xia
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis*; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013343:Styrenes / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D001578:Benzopyrans; D006835:Hydrazones; D013343:Styrenes; D014105:Tosyl Compounds; C018238:beta-bromostyrene; D010165:Palladium