title: A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
abstract: A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py-Cbl), a water-soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy-poly(ethylene glycol)114 -block-poly(L -lysine hydrochloride)200. This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.
authors.affiliation: State Key Laboratory of Chemical Engineering, Department of Chemistry, Zhejiang University, Hangzhou, 310027, P. R. China.
authors.forename: Guocan
authors.initials: G
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Yu
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Mao
authors.forename: Changyou
authors.initials: C
authors.lastname: Gao
authors.forename: Feihe
authors.initials: F
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D045744:Cell Line, Tumor / Q000187:drug effects; D002699:Chlorambucil / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D006801:Humans; D008239:Lysine / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D053769:Nanocapsules / Q000627:therapeutic use*; D009369:Neoplasms / Q000473:pathology*; D010777:Photochemistry; D011355:Prodrugs / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D015203:Reproducibility of Results; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008823:Micelles; D053769:Nanocapsules; D011355:Prodrugs; D000644:Quaternary Ammonium Compounds; C581440:pillar(6)arene; D014867:Water; D002699:Chlorambucil; D008239:Lysine
keywords: controlled release; drug delivery; host-guest systems; pillararenes; supramolecular chemistry