title: Prognostic significance of admission levels of cardiac indicators in patients with acute ischaemic stroke: prospective observational study.
abstract: OBJECTIVE
  The performance of cardiac indicators as determinants of stroke outcomes remains debatable, therefore the present study focused on the short-term prognostic value of cardiac indicators in patients who had experienced acute ischaemic stroke.
  
  
  METHODS
  Consecutive patients with acute ischaemic stroke were enrolled in a prospective stroke registry. Data on demographics, clinical characteristics and cardiac indicator levels (including troponin I, creatine kinase-MB, myoglobin and brain natriuretic peptide) were prospectively collected. Receiver operating characteristic curves and binary logistic regression models were used to examine the performance of variables in predicting poor functional outcomes (modified Rankin Scale score 2-6).
  
  
  RESULTS
  Out of 337 patients with acute ischaemic stroke, myoglobin had the greatest power for predicting poor outcomes among the cardiac indicators. Forward stepwise multivariate logistic regression analysis revealed that myoglobin could independently predict short-term outcomes. Spearman's rank correlation tests indicated a positive correlation between myoglobin levels and stroke severity.
  
  
  CONCLUSIONS
  Among cardiac indicators, myoglobin may be an independent predictor of short-term outcomes in patients with acute ischaemic stroke.
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Neurology, Huashan Hospital, Fudan University School of Medicine, Shanghai, China.
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Hairong
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Emergency, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China drshumingpan@hotmail.com.
authors.forename: Shuming
authors.initials: S
authors.lastname: Pan
mesh_terms: D000368:Aged; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D006760:Hospitalization; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D020521:Stroke / Q000097:blood* / Q000401:mortality; D019210:Troponin I / Q000097:blood*
chemical_list: D009211:Myoglobin; D019210:Troponin I; D020097:Natriuretic Peptide, Brain; D052279:Creatine Kinase, MB Form
keywords: Acute ischaemic stroke; cardiac indicators; myoglobin; prognostic significance