title: Hospital admissions for acute myocardial infarction before and after implementation of a comprehensive smoke-free policy in Uruguay: experience through 2010.
abstract: BACKGROUND
  Comprehensive smoke-free laws have been followed by drops in hospitalisations for acute myocardial infarction (AMI), including in a study with 2 years follow-up for such a law in Uruguay.
  
  
  METHODS
  Multiple linear and negative binomial regressions for AMI admissions (ICD-10 code 121) from 37 hospitals for 2 years before and 4 years after Uruguay implemented a 100% nationwide smoke-free law.
  
  
  RESULTS
  Based on 11 135 cases, there was a significant drop of -30.9 AMI admissions/month (95% CI -49.8 to -11.8, p=0.002) following implementation of the smoke-free law. The effect of the law did not increase or decrease over time following implementation (p=0.234). This drop represented a 17% drop in AMI admissions following the law (IRR=0.829, 95% CI 0.743 to 0.925, p=0.001).
  
  
  CONCLUSIONS
  Adding two more years of follow-up data confirmed that Uruguay's smoke-free law was followed by a substantial and sustained reduction in AMI hospitalisations.
authors.affiliation: Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Ernesto Marcelo
authors.initials: EM
authors.lastname: Sebrié
authors.affiliation: Cetro de Investigación para la Epidemia del Tabaquismo, Montevideo, Uruguay.
authors.forename: Edgardo
authors.initials: E
authors.lastname: Sandoya
authors.affiliation: Cetro de Investigación para la Epidemia del Tabaquismo, Montevideo, Uruguay.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Bianco
authors.affiliation: Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, New York, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Hyland
authors.affiliation: Departments of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: K Michael
authors.initials: KM
authors.lastname: Cummings
authors.affiliation: Department of Medicine (Cardiology), Center for Tobacco Control Research and Education, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.
authors.forename: Stanton A
authors.initials: SA
authors.lastname: Glantz
mesh_terms: D000328:Adult; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy; D011634:Public Health / Q000331:legislation & jurisprudence*; D061845:Smoke-Free Policy; D012907:Smoking / Q000331:legislation & jurisprudence*; D016540:Smoking Cessation / Q000331:legislation & jurisprudence*; D000074606:Smoking Prevention; D014028:Tobacco Smoke Pollution / Q000331:legislation & jurisprudence*; D014583:Uruguay; D017132:Workplace
chemical_list: D014028:Tobacco Smoke Pollution
keywords: Low/Middle income country; Secondhand smoke; Surveillance and monitoring