title: Hydrolytically degradable thiol-ene hydrogels for protein release.
abstract: A new degradable PEG-diester-dinorbornene/PEG-triester-trithiol hydrogel was evaluated for protein release. The hydrogel polymerized rapidly with seconds of UV irradiation and subsequently hydrolytically degraded in aqueous buffer over the course of approximately 3 weeks. Further, the hydrogel enabled the encapsulation and release of a model protein, bovine serum albumin (BSA), over 7 days with ~ 90% released at 48 h. This study serves as a proof-of-concept for the creation of hydrolytically degradable, PEG-ester-thiol-based hydrogels by a photoinitiated step growth mechanism for protein release. With this approach, degradation and release rates could be tuned by varying the monomer molecular weight and functionality in future studies.
authors.affiliation: Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Rehmann
authors.affiliation: Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716.
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Garibian
authors.affiliation: Department of Chemical & Biomolecular Engineering, University of Delaware, 150 Academy Street, Colburn Laboratory, Newark, Delaware, U.S.A. 19716 ; Department of Materials Science & Engineering, University of Delaware, Newark, Delaware, U.S.A. 19716.
authors.forename: April M
authors.initials: AM
authors.lastname: Kloxin
keywords: degradation; drug delivery systems; hydrogels; photopolymerization; thiol–ene