title: Effect of textured eye drop bottles on the photostability of pranoprofen 0.1% ophthalmic solution.
abstract: BACKGROUND
  Ophthalmic solutions are usually filled in a plastic bottle due to its durability and disposability. In Japan, photostability is one of the concerns for the quality control because an eye drop bottle must be a transparent container.
  
  
  OBJECTIVE
  The present work studied the effect of textured eye drop bottles on its light blocking to improve the photostability of ophthalmic solutions.
  
  
  METHODS
  We investigated the photostability of Pranoprofen ophthalmic solution filled in a variety of textured eye drop bottles. Pranoprofen content was analyzed by high-performance liquid chromatography and surface structure of textured eye drop bottles was evaluated by transmittance, calculated average roughness (Ra) and haze intensity.
  
  
  RESULTS
  We observed that eye drop bottle which had greater than Ra value of 1.0 µm and haze intensity 62% clearly showed photostability improvement.
  
  
  CONCLUSIONS
  This report is the first one which shows that photostability of ophthalmic solution is improved by using textured eye drop bottle. Moreover, this approach is a simple and effective method to improve the photostability. This method is available for not only various ophthalmic applications but also other liquid pharmaceuticals or food products.
authors.affiliation: a Senju Pharmaceutical Co., Ltd , Nishiku Kobe, Hyogo , Japan.
authors.forename: Kinya
authors.initials: K
authors.lastname: Iwatsuka
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Inada
authors.forename: Hiroki
authors.initials: H
authors.lastname: Ueoka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Masaki
authors.initials: M
authors.lastname: Maeda
authors.forename: Masazumi
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yasueda
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D001578:Benzopyrans / Q000008:administration & dosage* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging; D004355:Drug Stability; D009883:Ophthalmic Solutions; D055668:Photochemical Processes; D011422:Propionates / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D009883:Ophthalmic Solutions; D011422:Propionates; C043940:pyranoprofen
keywords: Eye drop bottle; Ra; haze; ophthalmic solution; photostability; pranoprofen; textured surface