title: Bispectral index and lower margin amplitude of the amplitude-integrated electroencephalogram in neonates.
abstract: BACKGROUND
  The lower margin amplitude (LMA) of the amplitude-integrated electroencephalogram (aEEG) is suppressed in neonates during deep sedation, a feature that is attributed to the bispectral index (BIS) in adults.
  
  
  OBJECTIVE
  We compare the BIS and the LMA of the aEEG in neonates.
  
  
  METHODS
  Thirty neurologically healthy neonates between 37 and 44 weeks postmenstrual age were included in this study. Twenty patients received sedoanalgesic therapy for various reasons. BIS and aEEG recordings were performed simultaneously. The digital data were imported in the numerical software environment Matlab®. The LMA of the aEEG was computed on a 1-min time scale and synchronized with the BIS data. The correlation between the time-dependent variables BIS and LMA was estimated using the Spearman rank correlation index.
  
  
  RESULTS
  The median correlation between BIS and LMA was 0.3. Inclusion of recordings of high signal quality only into analysis improved the median correlation index to 0.6.
  
  
  CONCLUSIONS
  We found a light-to-moderate correlation between BIS and LMA in our study cohort and a good correlation in the subgroup with high signal quality.
authors.affiliation: Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Tobias
authors.initials: T
authors.lastname: Werther
authors.forename: Monika
authors.initials: M
authors.lastname: Olischar
authors.forename: Vito
authors.initials: V
authors.lastname: Giordano
authors.forename: Christine
authors.initials: C
authors.lastname: Czaba
authors.forename: Thomas
authors.initials: T
authors.lastname: Waldhoer
authors.forename: Angelika
authors.initials: A
authors.lastname: Berger
authors.forename: Arnold
authors.initials: A
authors.lastname: Pollak
authors.forename: Philipp
authors.initials: P
authors.lastname: Deindl
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D058256:Brain Waves / Q000187:drug effects*; D054810:Deep Sedation / Q000379:methods; D004569:Electroencephalography / Q000187:drug effects / Q000379:methods; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D064926:Neurophysiological Monitoring / Q000379:methods; D014673:Vecuronium Bromide / Q000494:pharmacology*
chemical_list: D000701:Analgesics, Opioid; D006993:Hypnotics and Sedatives; D009466:Neuromuscular Blocking Agents; D009020:Morphine; D014673:Vecuronium Bromide; D008874:Midazolam; D005283:Fentanyl