title: Spindle cell lipoma of the tongue: a clinicopathologic study of 8 cases and review of the literature.
abstract: Spindle cell lipoma is a histologically distinct variant of lipoma characteristically arising in the subcutis of the posterior neck, upper back, or shoulder. Spindle cell lipomas infrequently occur within the oral cavity and, in particular, rarely involve the tongue. The clinical and pathologic features of eight cases of spindle cell lipoma affecting the tongue were analyzed. The study group included five men and three women ranging in age from 35 to 80 years (mean 57.4 years). Most lesions presented as either a painless or slowly growing lingual mass. The tumors were well circumscribed and characterized microscopically by a mixture of mature adipocytes, cytologically bland spindle cells, and interspersed bundles of thick collagen fibers in variable proportions. Myxoid stroma was a prominent feature in three lesions. The spindle cells were positive with CD34, while negative with S-100 protein, desmin, and smooth muscle actin. Treatment consisted of local excision in all cases. There have been no recurrences to date, with clinical follow up information available for all patients (range 11-118 months; mean 50.8 months). Lingual examples of spindle cell lipoma should be distinguished from other fat containing spindle cell neoplasms that can arise at this anatomic site.
authors.affiliation: Department of Pathology, Southern California Permanente Medical Group, Kaiser Permanente Orange County-Anaheim Medical Center, 3440 East La Palma Avenue, Anaheim, CA, 92806, USA, Sean.K.Lau@kp.org.
authors.forename: Sean K
authors.initials: SK
authors.lastname: Lau
authors.forename: Justin A
authors.initials: JA
authors.lastname: Bishop
authors.forename: Lester D R
authors.initials: LD
authors.lastname: Thompson
mesh_terms: D000199:Actins / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003893:Desmin / Q000378:metabolism; D005260:Female; D006801:Humans; D008067:Lipoma / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019647:Oral Surgical Procedures; D009418:S100 Proteins / Q000378:metabolism; D014062:Tongue Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D003893:Desmin; D009418:S100 Proteins