title: Filamin: a structural and functional biomolecule with important roles in cell biology, signaling and mechanics.
abstract: Focal adhesions are the immediate sites of the cell's adhesive interaction with the extracellular matrix and as such play a key role in mechanosensing and mechanotransduction at the edge of the cell interface with its surrounding microenvironment. A multitude of proteins orchestrate this mechanochemical communication process between the cell and its outside world. Filamin is a member of focal adhesion protein machinery that also plays a key role in regulating and bundling the acting filament network. A brief review is presented here on filamin and its important protein partners with the aim to shed light on the role of filamin's protein-protein interaction network in cell mechanobiology.
authors.forename: Hassan P
authors.initials: HP
authors.lastname: Modarres
authors.forename: Mohammad R K
authors.initials: MR
authors.lastname: Mofradt
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D064448:Filamins / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D064448:Filamins