title: Muscle strength, motor performance, cardiac and muscle biomarkers in detection of muscle side effects during and after acute lymphoblastic leukemia treatment in children.
abstract: Muscle side effects have not been frequently assessed in childhood acute lymphoblastic leukemia (ALL) patients. Our objective was to determine the early and late muscle side effects during childhood ALL treatment. To this end, we examined the early muscle side effects in 15 newly diagnosed "therapy patients" (group I), and the late side effects in 18 ALL survivors "off therapy patients" (group II). Muscle side effects were assessed by measuring hand grip strength (HGS), the "timed up and go" (TUG) test, creatine phosphokinase, myoglobin, plasma electrolytes, cardiac troponin I before and after induction chemotherapy in group I. The same parameters and cranial radiotherapy dose were examined in group II at a single timepoint. Cumulative doses of chemotherapy were calculated, and echocardiograms were obtained for each group. As a result, we found that the HGS and TUG measures of group I at the end of induction were poorer than measures of the first admission, control subjects, and group II. Low HGS measures had been normalized over time, but the TUG measures remained poor. Overt rhabdomyolysis and pyomyositis were not detected in any of the patients. These results suggested that muscle side effect monitoring might be helpful in the follow-up of children with ALL.
authors.affiliation: Divisions of *Pediatric Hematology ‡Pediatric Biochemistry, Dr A.Y. Ankara Oncology Training and Research Hospital †Division of Physical Therapy and Rehabilitation, Yildirim Beyazit University, Ankara, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Akyay
authors.forename: Lale
authors.initials: L
authors.lastname: Olcay
authors.forename: Nebahat
authors.initials: N
authors.lastname: Sezer
authors.forename: Çiğdem
authors.initials: Ç
authors.lastname: Atay Sönmez
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D016371:Cranial Irradiation / Q000009:adverse effects; D003402:Creatine Kinase / Q000097:blood; D004573:Electrolytes / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D053580:Muscle Strength / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009211:Myoglobin / Q000378:metabolism; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D004573:Electrolytes; D009211:Myoglobin; D003402:Creatine Kinase