title: Overexpressed miRNA-137 inhibits human glioma cells growth by targeting Rac1.
abstract: Previous studies have shown that miR-137 functions as a tumor suppressor in various cancers, but its role in the initiation and development of gliomas is still unknown. Currently, we found that miR-137 exhibited the most significant increase in normal brain tissues compared with glioma specimens, and the miR-137 expression was greatly decreased with the ascending of tumor pathological grades. Furthermore, overexpression of miR-137 in vitro by chemically synthesized miR-137 mimics suppressed the proliferation, inhibited cell cycle arrest in the G1/G0 phase, and induced cell apoptosis. The tumor-suppressive effects of miR-137 were indeed induced by Rac1, which was verified as a direct target of miR-137. These findings indicate that miR-137 inhibits the growth of gliomas cells by directly targeting Rac1, suggesting that miR-137 could be a new important therapeutic strategy for glioma treatment and warrants further investigation.
authors.affiliation: 1 Department of Neurosurgery, Fourth Affiliated Hospital of Nantong University , First Hospital of Yancheng, Yancheng, China .
authors.forename: Guan
authors.initials: G
authors.lastname: Sun
authors.forename: Ying
authors.initials: Y
authors.lastname: Cao
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Lihua
authors.initials: L
authors.lastname: Sun
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Zhengqiang
authors.initials: Z
authors.lastname: Wan
authors.forename: Linshan
authors.initials: L
authors.lastname: Fu
authors.forename: Yongping
authors.initials: Y
authors.lastname: You
mesh_terms: D017209:Apoptosis; D001923:Brain Chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016543:Central Nervous System Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology*; D019938:Cyclin D1 / Q000378:metabolism; D059585:G1 Phase Cell Cycle Checkpoints; D005910:Glioma / Q000737:chemistry / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D035683:MicroRNAs / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D015398:Signal Transduction; D014162:Transfection; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2; C107953:RAC1 protein, human; D034741:RNA, Small Interfering; D019938:Cyclin D1; D020778:Matrix Metalloproteinase 2; D020830:rac1 GTP-Binding Protein
keywords: Rac1; glioblastoma; miR-137