title: Immunological responses triggered by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis.
abstract: Photothermal ablation of primary tumors with single-walled carbon nanotubes is demonstrated to be able to trigger significant adaptive immune responses, which are not observed if tumors are removed by surgical resection. Such a treatment in combination with anti-CTLA-4 antibody therapy is able to prevent the development of tumor metastasis, which is a major cause of cancer death.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Ligeng
authors.initials: L
authors.lastname: Xu
authors.forename: Chao
authors.initials: C
authors.lastname: Liang
authors.forename: Jian
authors.initials: J
authors.lastname: Xiang
authors.forename: Rui
authors.initials: R
authors.lastname: Peng
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D000906:Antibodies / Q000737:chemistry* / Q000276:immunology / Q000627:therapeutic use; D060908:CTLA-4 Antigen / Q000276:immunology*; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D015996:Survival Rate
chemical_list: D000906:Antibodies; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D016207:Cytokines; D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols
keywords: anti-CTLA-4; cancer metastasis inhibition; immunotherapy; photothermal therapy; single-walled carbon nanotubes