title: HER2 expression in ovarian mucinous carcinomas in Tunisia.
abstract: BACKGROUND
  Ovarian mucinous carcinoma has a poor prognosis in advanced stages and a poor response to conventional chemotherapy. An efficient treatment is not yet available. We heere investigated HER2 expression and the potential for trastuzumab therapy in ovarian mucinous tumors.
  
  
  METHODS
  Immunohistochemistry was performed in formalin-fixed, paraffin-embedded tissue from 27 ovarian mucinous tumors including 14 carcinomas and 13 borderline tumors diagnosed in the Pathology Department, Farhet Hached Hospital, Sousse, between 1993 and 2013. The HercepTest (DAKO) was used for immunohistochemistry.
  
  
  RESULTS
  HER2 expression was observed in only one borderline tumor (7.7%) and in 14.3% of mucinous carcinomas of the ovary.
  
  
  CONCLUSIONS
  Our results suggest that trastuzumab therapy would be an option for patients with mucinous carcinoma when the tumor has HER2 overexpression.
authors.affiliation: Research Unit03/UR/08-13, Cancer Epidemiology and Cytopathology in Tunisian Center, Faculty of Medicine, Sousse, Tunisia E-mail : missaouinabiha@live.fr.
authors.forename: Nabiha
authors.initials: N
authors.lastname: Missaoui
authors.forename: Soumaya Ben
authors.initials: SB
authors.lastname: Abdelkarim
authors.forename: Malak
authors.initials: M
authors.lastname: Ayachi
authors.forename: Sihem
authors.initials: S
authors.lastname: Hmissa
authors.forename: Mohamed Taher
authors.initials: MT
authors.lastname: Yaacoubi
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D014416:Tunisia; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human