title: Nrdp1 inhibits metastasis of colorectal cancer cells by EGFR signaling-dependent MMP7 modulation.
abstract: The molecular mechanism underlying cancer invasiveness and metastasis of colorectal cancer (CRC) remains elusive. Here we reported a strong correlation of the levels of neuregulin receptor degradation protein-1 (Nrdp1) and matrix metalloproteinase-7 (MMP7) in CRC from the patients. We then used a human CRC line, Caco-2, to study the underlying molecular basis. We found that Nrdp1 inhibited the phosphorylation of ErB3, a key player in epidermal growth factor receptor (EGFR) signaling in Caco-2 cells, which is required for activation of MMP7 to promote cell invasion. Our findings thus reveal Nrdp1, EGFR signaling, and MMP7 as promising therapeutic targets for preventing the metastasis of CRC.
authors.affiliation: Department of General Surgery, Jinan Central Hospital, Shandong University, Jinan, 250013, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Jiang
authors.forename: Shaochuan
authors.initials: S
authors.lastname: Sun
authors.forename: Guoqin
authors.initials: G
authors.lastname: Liu
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Niu
mesh_terms: D018938:Caco-2 Cells; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020783:Matrix Metalloproteinase 7 / Q000096:biosynthesis* / Q000235:genetics; D009361:Neoplasm Invasiveness / Q000235:genetics; D009362:Neoplasm Metastasis; D010766:Phosphorylation; D020893:Receptor, ErbB-3 / Q000235:genetics; D015398:Signal Transduction; D044767:Ubiquitin-Protein Ligases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C452580:RNF41 protein, human; D044767:Ubiquitin-Protein Ligases; C512478:EGFR protein, human; C581292:ERBB3 protein, human; D066246:ErbB Receptors; D020893:Receptor, ErbB-3; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7