title: Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients.
abstract: OBJECTIVE
  To evaluate the effects of systemic doxycycline on clinical and microbiological parameters of diabetic subjects with chronic periodontitis.
  
  
  METHODS
  This 9-month multi-center, randomized, parallel, single-blinded study was conducted from different hospitals in Riyadh, Saudi Arabia between April 2010 and December 2010. A total of 76 diabetic subjects with chronic periodontitis were randomized into 2 groups: control group (CG) received only scaling and root planing (SRP), and the treatment group (TG) receiving systemic doxycycline during the reevaluation visit 45 days after the completion of SRP. Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, 3, and 6 months  after the use of systemic doxycycline. Microbiological analysis comprised the detection of Tannerella forsythia (Tf), Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi) by polymerase chain reaction method.
  
  
  RESULTS
  Sixty-eight (33 CG and 35 TG) subjects completed the study. Greater reduction in the population of Tf, Pg, and Pi were observed in TG compared with CG in the first month after the administration of systemic doxycycline. The TG showed a significant improvement in gingival index scores compared with the CG (p&lt;0.05) by the end of the first and 6 months after the administration of doxycycline.
  
  
  CONCLUSIONS
  Adjunct systemic doxycycline can be associated with a reduction of Tf, Pg, and Pi in the first month after the administration of doxycycline with an improvement in the GI.
authors.affiliation: Department of Preventive Dental Sciences, King Abdulaziz University, King Saud University, Riyadh, Kingdom of Saudi Arabia.
authors.forename: Abeer M
authors.initials: AM
authors.lastname: Al-Nowaiser
authors.forename: Hamad
authors.initials: H
authors.lastname: Al-Zoman
authors.forename: Jagan K
authors.initials: JK
authors.lastname: Baskaradoss
authors.forename: Asirvatham A
authors.initials: AA
authors.lastname: Robert
authors.forename: Khalid H
authors.initials: KH
authors.lastname: Al-Zoman
authors.forename: Abdulaziz M
authors.initials: AM
authors.lastname: Al-Sohail
authors.forename: Abdulaziz S
authors.initials: AS
authors.lastname: Al-Suwyed
authors.forename: Sebastian G
authors.initials: SG
authors.lastname: Ciancio
authors.forename: Sultan A
authors.initials: SA
authors.lastname: Al-Mubarak
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016866:Bacteroidaceae Infections / Q000150:complications / Q000628:therapy*; D041963:Bacteroidetes / Q000235:genetics / Q000302:isolation & purification; D055113:Chronic Periodontitis / Q000150:complications / Q000628:therapy*; D004269:DNA, Bacterial / Q000032:analysis*; D012534:Dental Scaling / Q000379:methods; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016871:Pasteurellaceae Infections / Q000150:complications / Q000628:therapy*; D010512:Periodontal Index; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000302:isolation & purification; D018713:Prevotella intermedia / Q000235:genetics / Q000302:isolation & purification; D016745:Root Planing / Q000379:methods*; D016037:Single-Blind Method; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D004318:Doxycycline