title: The impact of pri-miR-218 rs11134527 on the risk and prognosis of patients with esophageal squamous cell carcinoma.
abstract: MicroRNA-218 (miR-218) acts as a tumor suppressor in numerous types of cancer by regulation of the expression of target genes. The aim of this study was to investigate whether polymorphisms in miR-218 LAMB3 pathway were associated with the risk and prognosis of esophageal squamous cell carcinoma (ESCC). Pri-mir-218 rs11134527 and LAMB3 rs2566 were genotyped in ESCC patients and 745 controls to assess their associations with cancer risk and overall survival. Pri-mir-218 rs11134527 was significantly associated with a decreased risk of ESCC under codominant, recessive and additive models. Although there was a significant association between rs11134527 and better survival of ESCC patients under codominant, recessive and additive models, the association disappeared after adjustment for TNM and LNM. However, further stratified analysis revealed that the association remained significant in patients with TNM stages I and II or non-LNM. Our data suggest that pri-miR-218 rs11134527 may contribute to the genetic susceptibility and prognosis for ESCC in Chinese Han population.
authors.affiliation: Department of Anesthesiology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Department of Pathology, Shanghai Cancer Center Fudan University Shanghai, China.
authors.forename: Chaofu
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Canlin
authors.initials: C
authors.lastname: Sun
authors.affiliation: Department of Anesthesiology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Yumin
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Nuclear Medicine, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Zhongqi
authors.initials: Z
authors.lastname: Ding
authors.affiliation: Department of Thoracic Surgery, Taizhou Central Hospital Taizhou, Zhejiang, China.
authors.forename: Xueling
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Junxing
authors.initials: J
authors.lastname: Huang
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China ; Department of Pathology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D014408:Biomarkers, Tumor / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000235:genetics; D002681:China / Q000453:epidemiology; D004938:Esophageal Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D016016:Proportional Hazards Models; D012307:Risk Factors; D000097794:Kalinin
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D035683:MicroRNAs; D000097794:Kalinin; C547471:MIRN218 microRNA, human
keywords: Esophageal squamous cell carcinoma; laminin 5; miR-218; single nucleotide polymorphism; susceptibility