title: Omentin, an adipokine with insulin-sensitizing properties, is negatively associated with insulin resistance in normal gestation.
abstract: OBJECTIVE
  Omentin, a newly identified adipokine, enhances insulin mediated glucose uptake in human adipocytes, thus, inducing systemic insulin-sensitizing effect. The aims of this study were to determine whether circulating maternal omentin levels are associated with insulin resistance indices and to assess which compartment, maternal, fetal, or placental, is the source of omentin in maternal circulation.
  
  
  METHODS
  Fasting serum glucose, insulin, and omentin were determined in 25 healthy pregnant women at the third trimester, before and 3 days after elective cesarean section. Cord blood omentin was measured in the 25 term neonates. Homeostasis model assessment (HOMA) was used to evaluate insulin sensitivity before and after delivery.
  
  
  RESULTS
  Antepartum maternal omentin levels were negatively correlated with insulin levels (r=-0.41, P=0.04) and positively correlated with insulin sensitivity (HOMA%S; r=0.4, P=0.04). Postpartum omentin levels were negatively correlated with maternal body mass index (r=-0.44, P=0.02). Median maternal omentin levels was comparable before and after delivery (57.2, inter-quartile range: 38.2-76.2 ng/mL vs. 53.4, 39.8-69.4 ng/mL, respectively, P=0.25) and highly correlated (r=0.83, P<0.001). Antepartum maternal and neonatal omentin levels did not differ significantly (fetal: 62.2, 44.3-74.2 ng/mL, P=0.77) and did not correlate (P=0.6).
  
  
  CONCLUSIONS
  Circulating maternal omentin levels are correlated with insulin resistance indices, suggesting that this adipokine may play a role in metabolic adaptations of normal gestation. The strong correlation between anteparum and postpartum maternal omentin levels, as well as the lack of association between maternal and neonatal omentin levels, suggest that placental or fetal compartments are unlikely as the main source of circulating maternal omentin.
authors.forename: Benny
authors.initials: B
authors.lastname: Brandt
authors.forename: Shali
authors.initials: S
authors.lastname: Mazaki-Tovi
authors.forename: Rina
authors.initials: R
authors.lastname: Hemi
authors.forename: Yoav
authors.initials: Y
authors.lastname: Yinon
authors.forename: Eyal
authors.initials: E
authors.lastname: Schiff
authors.forename: Roy
authors.initials: R
authors.lastname: Mashiach
authors.forename: Hannah
authors.initials: H
authors.lastname: Kanety
authors.forename: Eyal
authors.initials: E
authors.lastname: Sivan
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016207:Cytokines / Q000097:blood* / Q000378:metabolism; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood* / Q000378:metabolism; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood*
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D007328:Insulin; D037102:Lectins