title: Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate.
abstract: The aim of this study was to determine the frequency of leukemia in parents of patients with nonsyndromic cleft lip and/or cleft palate (NSCL/P). This case-control study evaluated first-degree family members of 358 patients with NSCL/P and 1,432 subjects without craniofacial alterations or syndromes. Statistical analysis was carried out using Fisher's test. From the 358 subjects with NSCL/P, 3 first-degree parents had history of leukemia, while 2 out of 1,432 subjects from the unaffected group had a family history of leukemia. The frequency of positive family history of leukemia was not significantly increased in first-degree relatives of patients with NSCL/P.
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Gonçalves
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
authors.forename: Daniella Reis Barbosa
authors.initials: DR
authors.lastname: Martelli
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
authors.forename: Ricardo Della
authors.initials: RD
authors.lastname: Coletta
authors.affiliation: Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, United State of America.
authors.forename: Alexandre Rezende
authors.initials: AR
authors.lastname: Vieira
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
authors.forename: Antônio Prates
authors.initials: AP
authors.lastname: Caldeira
authors.affiliation: Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.
authors.forename: Hercílio
authors.initials: H
authors.lastname: Martelli
mesh_terms: D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002971:Cleft Lip / Q000150:complications*; D002972:Cleft Palate / Q000150:complications*; D005190:Family; D005260:Female; D006801:Humans; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology*; D008297:Male; D012307:Risk Factors