title: Proteinase inhibitors: a promising drug class for treating leishmaniasis.
abstract: This review presents and discusses the current status and perspectives of leishmaniasis treatment, with a special focus on the use of proteinase inhibitors. The history of treatment development, the first- and second-choice modern drugs and the advantages and disadvantages of using proteinases inhibitors as leishmanicidal treatments are presented and discussed. The reports gathered herein confirm the potential usefulness of proteinases inhibitors as an alternative or complement to the current leishmaniasis treatments. They also support the hypothesis that a combined treatment with multiple proteinase inhibitors may be efficient against Leishmania infections in vertebrate hosts.
authors.forename: Bernardo Acacio Santini
authors.initials: BA
authors.lastname: Pereira
authors.forename: Franklin
authors.initials: F
authors.lastname: Souza-Silva
authors.forename: Mariana
authors.initials: M
authors.lastname: Silva-Almeida
authors.forename: Raquel
authors.initials: R
authors.lastname: Santos-de-Souza
authors.forename: Luiz Filipe
authors.initials: LF
authors.lastname: Gonçalves de Oliveira
authors.forename: Michelle Lopes
authors.initials: ML
authors.lastname: Ribeiro-Guimarães
authors.affiliation: Laboratorio de Biologia Molecular e Doenças Endemicas, Instituto Oswaldo Cruz - Fiocruz, Avenida Brasil, 4365 Pavilhao Leonidas Deane, sala 209A, Manguinhos, Rio de Janeiro, RJ - CEP: 21040-900, Brasil. calves@ioc.fiocruz.br.
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Alves
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000494:pharmacology; D015853:Cysteine Proteinase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006801:Humans; D007896:Leishmaniasis / Q000188:drug therapy*
chemical_list: D000981:Antiprotozoal Agents; D015853:Cysteine Proteinase Inhibitors