title: Clinical significance of molecular diagnosis for gastric cancer lymph node micrometastasis.
abstract: Advances in molecular diagnostic tools have allowed the identification of lymph node micrometastasis (LNM), including isolated tumor cells, in cancer patients. While immunohistochemistry and reverse transcription-polymerase chain reaction have been used to identify LNM in patients with gastric cancer, the clinical significance of this finding remains unclear. Recently, minimally invasive treatments, such as endoscopic submucosal dissection and laparoscopic surgery, are widely performed to help improve postsurgical quality of life (QOL). However, it is important to maintain the balance between QOL and curability when making treatments decision for patients with gastric cancer. If minimally invasive surgery based on accurate intraoperative LNM diagnosis was established, it could be performed safely. Therefore, we reviewed the clinical significance of LNM detected by molecular techniques as an important target for treatment decision making with gastric cancer patients.
authors.affiliation: Hiromichi Sonoda, Tohru Tani, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Sonoda
authors.affiliation: Hiromichi Sonoda, Tohru Tani, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Tani
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D003661:Decision Support Techniques; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000737:chemistry / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D025202:Molecular Diagnostic Techniques; D061206:Neoplasm Micrometastasis; D009367:Neoplasm Staging; D018579:Patient Selection; D011237:Predictive Value of Tests; D011788:Quality of Life; D013274:Stomach Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Gastric cancer; Lymph node micrometastasis; Minimally invasive surgery; Molecular technique; Sentinel lymph node