title: Sustained delivery of biomolecules from gelatin carriers for applications in bone regeneration.
abstract: Local delivery of therapeutic biomolecules to stimulate bone regeneration has matured considerably during the past decades, but control over the release of these biomolecules still remains a major challenge. To this end, suitable carriers that allow for tunable spatial and temporal delivery of biomolecules need to be developed. Gelatin is one of the most widely used natural polymers for the controlled and sustained delivery of biomolecules because of its biodegradability, biocompatibility, biosafety and cost-effectiveness. The current study reviews the applications of gelatin as carriers in form of bulk hydrogels, microspheres, nanospheres, colloidal gels and composites for the programmed delivery of commonly used biomolecules for applications in bone regeneration with a specific focus on the relationship between carrier properties and delivery characteristics.
authors.affiliation: Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: Jiankang
authors.initials: J
authors.lastname: Song
authors.forename: Sander Cg
authors.initials: SC
authors.lastname: Leeuwenburgh
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage; D001861:Bone Regeneration; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage; D005780:Gelatin / Q000008:administration & dosage*; D053773:Transforming Growth Factor beta1 / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D019485:Bone Morphogenetic Proteins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D053773:Transforming Growth Factor beta1; D016222:Fibroblast Growth Factor 2; D005780:Gelatin