title: Galectin-3 and plasma cytokines in patients with acute myocardial infarction.
abstract: OBJECTIVE
  To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI).
  
  
  METHODS
  The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels in plasma using enzyme-linked immunosorbent assays (ELISAs). We measured levels of C-reactive protein (CRP) via the nephelometric method.
  
  
  RESULTS
  Patients with AMI showed significantly higher plasma Gal-3, TNF-α, and IL-6 levels compared with controls. Gal-3 levels were positively and significantly correlated with plasma IL-6, TNF-α, and CRP levels in the control and patient groups.
  
  
  CONCLUSIONS
  Our findings suggest that Gal-3 can be a new circulating biomarker of inflammation associated with AMI.
authors.affiliation: Department of Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey.
authors.forename: A Ata
authors.initials: AA
authors.lastname: Alturfan
authors.affiliation: Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Isık
authors.initials: I
authors.lastname: Basar
authors.affiliation: Department of Biochemistry, Faculty of Dentistry, Marmara University, Nisantasi, Istanbul, Turkey ebruemekli@yahoo.com.
authors.forename: Ebru
authors.initials: E
authors.lastname: Emekli-Alturfan
authors.affiliation: Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Ayan
authors.affiliation: Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Lale
authors.initials: L
authors.lastname: Koldas
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Medipol University, Istanbul, Turkey.
authors.forename: Nesrin
authors.initials: N
authors.lastname: Emekli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D037502:Galectin 3 / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*
chemical_list: D015415:Biomarkers; D016207:Cytokines; D037502:Galectin 3; D018836:Inflammation Mediators
keywords: AMI; CRP; Galectin-3; TNF-α; cytokines; inflammation