title: Evaluation of intraabdominal adhesion generating potentials of ankaferd and calcium alginate used as hemostatic agents.
abstract: OBJECTIVE
  The present study aimed to evaluate intra-abdominal adhesion generating potential of Ankaferd Blood Stopper (ABS), which was used as postoperative hemostatic agent in the rats that underwent surgery, in comparison with Ca-alginate.
  
  
  METHODS
  Totally, 30 rats were randomized into 4 groups. In the control group, 1x1 cm peritoneum was removed from the right lower quadrant after cecal abrasion. In the other two study groups, the same procedure was performed after Ankaferd Blood Stopper and Ca-alginate application respectively. RESULTS were evaluated both histopathologically and by adhesion scoring methods. All results underwent statistical analysis.
  
  
  RESULTS
  Comparing overall results, no statistically significant difference was found between the sham, control, ABS and Ca-alginate groups (p = 0.099). Paired group comparisons revealed no statistically significant difference between the sham group and the control, ABS, and Ca-alginate groups (p = 0.222, p = 0.222, and p = 0.833 respectively). It was observed that there was no statistically significant difference between the control and ABS groups (p = 0.505), but there was a statistically significant difference between the control and Ca-alginate groups with Bonferroni correction (p = 0.028). Histopathological examination revealed no statistical difference between the groups.
  
  
  CONCLUSIONS
  In conclusion, intra-abdominal adhesion generating potentials of Ca-alginate and ABS were experimentally evaluated and macroscopic and microscopic comparisons revealed no significant difference between sham, control, Ca-alginate, and ABS groups (Fig. 8, Ref. 36). Text in PDF www.elis.sk. agent.
authors.forename: S D
authors.initials: SD
authors.lastname: Tuncal
authors.forename: K
authors.initials: K
authors.lastname: Kismet
authors.forename: B
authors.initials: B
authors.lastname: Kilicoglu
authors.forename: A M
authors.initials: AM
authors.lastname: Barlas
authors.forename: A K
authors.initials: AK
authors.lastname: Onalan
authors.forename: S
authors.initials: S
authors.lastname: Temel
authors.forename: M K
authors.initials: MK
authors.lastname: Urhan
authors.forename: M A
authors.initials: MA
authors.lastname: Gonultas
authors.forename: S
authors.initials: S
authors.lastname: Hucumenoglu
authors.forename: O
authors.initials: O
authors.lastname: Guler
mesh_terms: D034841:Abdominal Cavity; D000464:Alginates / Q000627:therapeutic use*; D000818:Animals; D002429:Cecal Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D020723:Glucuronic Acid / Q000627:therapeutic use; D006490:Hemostatics / Q000627:therapeutic use*; D006603:Hexuronic Acids / Q000627:therapeutic use; D007813:Laparotomy / Q000009:adverse effects; D010936:Plant Extracts / Q000627:therapeutic use*; D019106:Postoperative Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D000267:Tissue Adhesions / Q000209:etiology
chemical_list: D000464:Alginates; D006490:Hemostatics; D006603:Hexuronic Acids; D010936:Plant Extracts; C539751:ankaferd blood stopper; D020723:Glucuronic Acid