title: Highly enantioselective Michael addition of 3-arylthio- and 3-alkylthiooxindoles to nitroolefins catalyzed by a simple cinchona alkaloid derived phosphoramide.
abstract: A new cinchona alkaloid derived bifunctional tertiary amine-phosphoramide is identified as a highly enantioselective catalyst for Michael addition of both unprotected 3-arylthio- and 3-alkylthiooxindoles to nitroolefins. The phosphoramide moiety of plays an indispensable role in this reaction.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062, China. hhwu@chem.ecnu.edu.cn jzhou@chem.ecnu.edu.cn.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Gao
authors.forename: Jin-Sheng
authors.initials: JS
authors.lastname: Yu
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Zhao
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhou
authors.forename: Hai-Hong
authors.initials: HH
authors.lastname: Wu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D063088:Phosphoramides / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002930:Cinchona Alkaloids; D007211:Indoles; D063088:Phosphoramides; D013438:Sulfhydryl Compounds; C005438:phosphoramide