title: Factors predicting the occurrence of a gastrojejunal anastomosis leak following gastric bypass.
abstract: BACKGROUND
  Occurrence of anastomotic leaks following Roux-en-Y gastric bypass (RYGB), arising principally from the gastro-jejunal anastomosis, is associated with significant morbidity and mortality. Their early detection and treatment is essential. However, a significant number of postoperative oral contrast studies fail to identify leaks, and a negative study providing false reassurance can lead to a delay in diagnosis and treatment. Physiological features including tachycardia, increased respiratory rate and pyrexia or elevations in C-reactive protein and white cell count are seen in patients with leaks. In this study we examine physiological and laboratory parameters in patients with and without anastomotic leaks following RYGB to try and improve the detection of leaks.
  
  
  OBJECTIVE
  To evaluate clinical signs and laboratory tests in determination of the development of gastrojejunal leaks after gastric bypass surgery.
  
  
  METHODS
  The study examined 116 consecutive patients undergoing laparoscopic RYGB. Clinical signs and laboratory results were reviewed retrospectively.
  
  
  RESULTS
  Four gastrojejunostomy leaks in our series were identified after RYGB surgery. All these patients were treated successfully. Leak patients' in-hospital stay was longer. Tachycardia among leak patients occurs from day 1 with 100% sensitivity and 87% specificity at a cut-off point of 90 bpm. A temperature difference appears on day 2 in leak patients. The CRP was higher on day 2 and 3 in leak patients. Higher intravenous fluid requirements were observed in patients with leaks.
  
  
  CONCLUSIONS
  Gastrojejunal anastomosis leak is associated with longer in-hospital treatment. The earliest significant indicators of a leak are tachycardia and positive fluid balance. A temperature spike and CRP rise occur on day 2. Leak patients matched SIRS WBC count criteria on day 3.
authors.affiliation: Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Antanas
authors.initials: A
authors.lastname: Mickevicius
authors.affiliation: Department of Bariatric and Gastrointestinal Surgery, Whittington NHS Trust, London, UK.
authors.forename: Pratik
authors.initials: P
authors.lastname: Sufi
authors.affiliation: Department of Bariatric and Gastrointestinal Surgery, Whittington NHS Trust, London, UK.
authors.forename: Dugal
authors.initials: D
authors.lastname: Heath
keywords: Roux-en-Y gastric bypass (RYGB); anastomosis leak; obesity