title: Fear memory formation can affect a different memory: fear conditioning affects the extinction, but not retrieval, of conditioned taste aversion (CTA) memory.
abstract: The formation of fear memory to a specific stimulus leads to subsequent fearful response to that stimulus. However, it is not apparent whether the formation of fear memory can affect other memories. We study whether specific fearful experience leading to fear memory affects different memories formation and extinction. We revealed that cued fear conditioning, but not unpaired or naïve training, inhibited the extinction of conditioned taste aversion (CTA) memory that was formed after fear conditioning training in rats. Fear conditioning had no effect on retrieval of CTA memory but specifically impaired its extinction. Extinguished fear memory, after fear extinction training, had no effect on future CTA memory extinction. Fear conditioning had no effect on CTA memory extinction if CTA memory was formed before fear conditioning. Conditioned taste aversion had no effect on fear conditioning memory extinction. We conclude that active cued fear conditioning memory can affect specifically the extinction, but not the formation, of future different memory.
authors.affiliation: Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa Haifa, Israel.
authors.forename: Gil
authors.initials: G
authors.lastname: Joels
authors.affiliation: Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa Haifa, Israel ; Department of Biology, Faculty of Natural Sciences, University of Haifa Haifa, Israel ; Center for Gene Manipulation in the Brain, University of Haifa Haifa, Israel ; Center for Brain and Behavior, University of Haifa Haifa, Israel.
authors.forename: Raphael
authors.initials: R
authors.lastname: Lamprecht
keywords: conditioned taste aversion; cued fear conditioning; learning and memory; memory extinction; memory retrieval