title: Preventive effects of chitosan coacervate whey protein on body composition and immunometabolic aspect in obese mice.
abstract: Functional foods containing bioactive compounds of whey may play an important role in prevention and treatment of obesity. The aim of this study was to investigate the prospects of the biotechnological process of coacervation of whey proteins (CWP) in chitosan and test its antiobesogenic potential.
  
  
  METHODS
  CWP (100 mg · kg · day) was administered in mice with diet-induced obesity for 8 weeks. The animals were divided into four groups: control normocaloric diet gavage with water (C) or coacervate (C-CWP), and high fat diet gavage with water (HF) or coacervate (HF-CWP).
  
  
  RESULTS
  HF-CWP reduced weight gain and serum lipid fractions and displayed reduced adiposity and insulin. Adiponectin was significantly higher in HF-CWP group when compared to the HF. The level of LPS in HF-W group was significantly higher when compared to HF-CWP. The IL-10 showed an inverse correlation between the levels of insulin and glucose in the mesenteric adipose tissue in the HF-CWP group. CWP promoted an increase in both phosphorylation AMPK and the amount of ATGL in the mesenteric adipose tissue in HF-CWP group.
  
  
  CONCLUSIONS
  CWP was able to modulate effects, possibly due to its high biological value of proteins. We observed a protective effect against obesity and improved the inflammatory milieu of white adipose tissue.
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil ; Departamento de Ciências Biológicas, Laboratório de Movimento Humano da Universidade São Judas Tadeu, 03166-000 São Paulo, SP, Brazil.
authors.forename: Gabriel Inácio de Morais Honorato
authors.initials: GI
authors.lastname: de Souza
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Aline Boveto
authors.initials: AB
authors.lastname: Santamarina
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Aline Alves
authors.initials: AA
authors.lastname: de Santana
authors.affiliation: Departamento de Educação Física da Universidade Estadual Paulista, Faculdade de Ciências e Tecnologia, 19060-900 Presidente Prudente, SP, Brazil.
authors.forename: Fábio Santos
authors.initials: FS
authors.lastname: Lira
authors.affiliation: Departamento de Nutrição das Faculdades Integradas Coração de Jesus-FAINC, 09020-240 Santo André, SP, Brazil.
authors.forename: Rachel
authors.initials: R
authors.lastname: de Laquila
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Mayara Franzoi
authors.initials: MF
authors.lastname: Moreno
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Eliane Beraldi
authors.identifier: 0000-0002-3071-9134
authors.initials: EB
authors.lastname: Ribeiro
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Claudia Maria da Penha Oller
authors.initials: CM
authors.lastname: do Nascimento
authors.affiliation: Departamento de Ciências Biológicas, Laboratório de Movimento Humano da Universidade São Judas Tadeu, 03166-000 São Paulo, SP, Brazil.
authors.forename: Bruno
authors.identifier: 0000-0003-4246-4703
authors.initials: B
authors.lastname: Rodrigues
authors.affiliation: Instituto de Ciências e Tecnologia da Universidade Federal de São Paulo, 04023-060 São José dos Campos, SP, Brazil.
authors.forename: Elisa
authors.initials: E
authors.lastname: Esposito
authors.affiliation: Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, 04023-060 São Paulo, SP, Brazil.
authors.forename: Lila Missae
authors.initials: LM
authors.lastname: Oyama
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D048271:Chitosan / Q000494:pharmacology* / Q000627:therapeutic use; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D051379:Mice; D008820:Mice, Obese; D008894:Milk Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism*; D000067816:Whey Proteins
chemical_list: D000276:Adjuvants, Immunologic; D008070:Lipopolysaccharides; D008894:Milk Proteins; D000067816:Whey Proteins; D048271:Chitosan