title: Selected oxidative stress parameters after single and repeated administration of octabromodiphenyl ether to rats.
abstract: OBJECTIVE
  Octabromodiphenyl ether (OctaBDE) was used as a flame retardant applied mostly in the manufacture of plastics utilized in the electrical and electronic industries. Owing to its long half-life and being regarded as an environmental pollutant, OctaBDE, like other polybrominated diphenyl ethers, has been classified as a persistent organic pollutant (POP). This study was carried out to assess the effects of oxidative stress (redox homeostasis) induced in rats by OctaBDE.
  
  
  METHODS
  Female Wistar rats exposed intragastrically to OctaBDE at single (25, 200 or 2000 mg/kg b.w.), or repeated (0.4, 2, 8, 40 or 200 mg/kg/day) doses during 7-28 days were used in the experiment. Selected oxidative stress parameters were determined in the liver and blood serum.
  
  
  RESULTS
  Administration (single or repeated) of OctaBDE to rats resulted in the impaired redox homeostasis, as evidenced by the increased levels of reduced (GSH) and oxidized (GSSG) glutathione in the liver, the reduced total antioxidant status (TAS) in serum and the increased concentration of malondialdehyde (MDA) in the liver. After multiple doses of OctaBDE, elevated activity of glutathione transferase (GST) in the liver was also noted.
  
  
  CONCLUSIONS
  After repeated administration of OctaBDE at the lowest dose (0.4 mg/kg/day), changes were observed in the parameters (MDA, TAS, GSSG) indicative of oxidative stress.
authors.affiliation: Department of Toxicology, Medical University of Lodz, Łódź, Poland, elzbieta.bruchajzer@umed.lodz.pl.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Bruchajzer
authors.forename: Barbara
authors.initials: B
authors.lastname: Frydrych
authors.forename: Anna
authors.initials: A
authors.lastname: Kilanowicz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sapota
authors.forename: Jadwiga A
authors.initials: JA
authors.lastname: Szymańska
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000032:analysis*; D005260:Female; D055768:Halogenated Diphenyl Ethers / Q000008:administration & dosage / Q000633:toxicity*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests
chemical_list: D015415:Biomarkers; D055768:Halogenated Diphenyl Ethers