title: AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity.
abstract: DNA mutations and genomic recombinations are the origin of oncogenesis, yet parts of developmental programs as well as immunity are intimately linked to, or even depend on, such DNA damages. Therefore, the balance between deleterious DNA damages and organismal survival utilizing DNA editing (modification and repair) is in continuous flux. The cytosine deaminases AID/APOBEC are a DNA editing family and actively participate in various biological processes. In conjunction with altered DNA repair, the mutagenic potential of the family allows for APOBEC3 proteins to restrict viral infection and transposons propagation, while AID can induce somatic hypermutation and class switch recombination in antibody genes. On the other hand, the synergy between effective DNA repair and the nonmutagenic potential of the DNA deaminases can induce local DNA demethylation to support epigenetic cellular identity. Here, we review the current state of knowledge on the mechanisms of action of the AID/APOBEC family in immunity and epigenetics.
authors.affiliation: DNA Editing in Immunity and Epigenetics, IFOM-Fondazione Instituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139 Milano, Italy.
authors.forename: Don-Marc
authors.initials: DM
authors.lastname: Franchini
authors.forename: Svend K
authors.initials: SK
authors.lastname: Petersen-Mahrt
mesh_terms: D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D004249:DNA Damage; D004268:DNA-Binding Proteins / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D007109:Immunity; D007136:Immunoglobulins / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D007136:Immunoglobulins; D011518:Proto-Oncogene Proteins; D003564:Cytidine Deaminase
keywords: AID; APOBEC; DNA demethylation; DNA repair; deaminase; epigenetics; immunity