title: [The effect of altered oxygen partial pressure on the resisitance to hypoxia and expression of oxygen-sensitive genes in Drosophila melanogaster].
abstract: As a result of resistance test to hypoxia of Drosophilas melanogaster of Oregon strain, we identified a high resistance (Group II) and low resistance (Group III) subpopulations of flies. Flies from groups II and III were incubated in a constant normobaric hypoxia (Po2=62-64 mm Hg) for 10 generations. A highly resistant group (Group IV) were exposed to a shortterm anoxia (Po,=1,5 mm Hg, 5 min) every generation. Larvae from Groups II, III, and IV demonstrated significantly elevated levels of Sir and CG 14740 expression. Larvae from Group II had a significantly higher expression of CG 14740 compared to group III. The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Berezovs'kyĭ
authors.forename: O H
authors.initials: OH
authors.lastname: Chaka
authors.forename: I H
authors.initials: IH
authors.lastname: Litovka
authors.forename: M I
authors.initials: MI
authors.lastname: Levashov
authors.forename: R V
authors.initials: RV
authors.lastname: Ianko
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D002950:Citrate (si)-Synthase / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D017344:Genes, Insect; D006655:Histone Deacetylases / Q000235:genetics*; D000860:Hypoxia / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D007814:Larva; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D037761:Sirtuins / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D002950:Citrate (si)-Synthase; C447899:Sirt2 protein, Drosophila; D037761:Sirtuins; D006655:Histone Deacetylases; D010100:Oxygen