title: Matrix metalloproteinase-1 (MMP1) polymorphism is associated with lowered risk of nasopharyngeal carcinoma in Asian population.
abstract: Data on the association between -1607 1G > 2G polymorphism in the promoter region of matrix metalloproteinase-1 (MMP1) and nasopharyngeal carcinoma (NPC) are conflicting. The aim of this study was to confirm whether this polymorphism was a causative factor of NPC. We searched PubMed, Embase, and China National Knowledge Infrastructure (CNKI) for studies on the present topic. A total of four publications (1,044 NPC patients and 1,284 healthy control subjects) were included and meta-analysis was performed to assess the association between -1607 1G > 2G polymorphism and NPC risk. Odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated for 1G1G versus 2G2G, 1G1G + 1G2G versus 2G2G, 1G1G versus 1G2G + 2G2G, 1G versus 2G, and 1G2G versus 2G2G contrast models. Meta-analysis results showed significantly reduced risk of NPC associated with the 1G1G versus 2G2G, 1G versus 2G and 1G2G versus 2G2G contrast models (OR = 0.61, 95 % CI 0.49-0.77; OR = 0.78, 95 % CI 0.65-0.92; OR = 0.86, 95 % CI 0.74-0.99, respectively). When we continued to perform subgroup analysis by ethnicity, the significant association persisted in Asian population and was most pronounced under the 1G2G versus 2G2G model (OR = 0.85, 95 % CI 0.73-0.99). These data suggested that MMP1 -1607 1G > 2G polymorphism was associated with reduced risk of NPC, particularly in the population of Asian descent.
authors.affiliation: Department of Otorhinolaryngology, Yantaishan Hospital Affiliated to Medical College of Taishan, 91 Jiefang Road, Yantai, 264000, Shandong, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Li
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Ge
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Xie
authors.forename: Guang-Ying
authors.initials: GY
authors.lastname: Xie
authors.forename: Chao
authors.initials: C
authors.lastname: Lv
mesh_terms: D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D020781:Matrix Metalloproteinase 1