title: The Influence of Dietary Fat Source on Life Span in Calorie Restricted Mice.
abstract: Calorie restriction (CR) without malnutrition extends life span in several animal models. It has been proposed that a decrease in the amount of polyunsaturated fatty acids (PUFAs), and especially n-3 fatty acids, in membrane phospholipids may contribute to life span extension with CR. Phospholipid PUFAs are sensitive to dietary fatty acid composition, and thus, the purpose of this study was to determine the influence of dietary lipids on life span in CR mice. C57BL/6J mice were assigned to four groups (a 5% CR control group and three 40% CR groups) and fed diets with soybean oil (high in n-6 PUFAs), fish oil (high in n-3 PUFAs), or lard (high in saturated and monounsaturated fatty acids) as the primary lipid source. Life span was increased (p < .05) in all CR groups compared to the Control mice. Life span was also increased (p < .05) in the CR lard mice compared to animals consuming either the CR fish or soybean oil diets. These results indicate that dietary lipid composition can influence life span in mice on CR, and suggest that a diet containing a low proportion of PUFAs and high proportion of monounsaturated and saturated fats may maximize life span in animals maintained on CR.
authors.affiliation: Department of Molecular Biosciences.
authors.forename: José A
authors.initials: JA
authors.lastname: López-Domínguez
authors.affiliation: Department of Molecular Biosciences, jjramsey@ucdavis.edu.
authors.forename: Jon J
authors.initials: JJ
authors.lastname: Ramsey
authors.affiliation: Department of Molecular Biosciences.
authors.forename: Dianna
authors.initials: D
authors.lastname: Tran
authors.affiliation: Comparative Pathology Laboratory, School of Veterinary Medicine, and.
authors.forename: Denise M
authors.initials: DM
authors.lastname: Imai
authors.affiliation: Comparative Pathology Laboratory, School of Veterinary Medicine, and.
authors.forename: Amanda
authors.initials: A
authors.lastname: Koehne
authors.affiliation: Comparative Pathology Laboratory, School of Veterinary Medicine, and.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Laing
authors.affiliation: Comparative Pathology Laboratory, School of Veterinary Medicine, and.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Griffey
authors.affiliation: Department of Public Health Sciences, School of Medicine, University of California, Davis.
authors.forename: Kyoungmi
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Public Health Sciences, School of Medicine, University of California, Davis.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Taylor
authors.affiliation: Department of Molecular Biosciences.
authors.forename: Kevork
authors.initials: K
authors.lastname: Hagopian
authors.affiliation: Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Campus de Excelencia Internacional Agroalimentario, ceiA3, Córdoba, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Villalba
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: López-Lluch
authors.affiliation: Centro Andaluz de Biología del Desarrollo (CABD), Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.
authors.forename: Plácido
authors.initials: P
authors.lastname: Navas
authors.affiliation: Department of Nutrition, University of California, Davis.
authors.forename: Roger B
authors.initials: RB
authors.lastname: McDonald
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D008136:Longevity; D051379:Mice; D008810:Mice, Inbred C57BL; D013024:Soybean Oil
chemical_list: D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D013024:Soybean Oil; C029310:lard
keywords: Aging; Calorie restriction; Dietary fat; Fatty acids; Life span