title: Inducing achiral aliphatic oligoureas to fold into helical conformations.
abstract: The ability of urea-linked oligomers of achiral diamines (achiral analogues of the well-established chiral oligourea foldamers) to adopt helical conformations was explored spectroscopically. Up to four achiral units were ligated either to a well-formed helical trimer or to a single chiral diamine, and the extent to which they adopted a screw-sense preference was determined by NMR and CD. In the best performing cases, a trimeric chiral oligourea and even a single cis-cyclohexanediamine monomer induced folding into a helical conformation.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK. clayden@man.ac.uk.
authors.forename: Romina
authors.initials: R
authors.lastname: Wechsel
authors.forename: Julien
authors.initials: J
authors.lastname: Maury
authors.forename: Juliette
authors.initials: J
authors.lastname: Fremaux
authors.forename: Scott P
authors.initials: SP
authors.lastname: France
authors.forename: Gilles
authors.initials: G
authors.lastname: Guichard
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clayden