title: Treatment of Kleine-Levin syndrome with acetazolamide.
abstract: Kleine-Levin syndrome (KLS) is a rare and disabling disorder characterized by recurrent episodes of hypersomnia as well as cognitive and behavioral abnormalities. Sadly, the treatment options are very limited and often ineffective. To our knowledge, there have been no reports in the literature for the use of acetazolamide as a treatment for this disorder. We report the case of a 26-year-old female patient with KLS in whom acetazolamide was used to treat recurrent hypersomnia and cognitive abnormalities. The patient had a dramatic improvement on acetazolamide in both the frequency and severity of her symptoms. The symptoms recurred when acetazolamide was stopped on two occasions and improved with resumption of the drug, leading us to conclude that its therapeutic effect was significant.
authors.affiliation: Stony Brook Department of Neurology, Stony Brook, NY.
authors.forename: Blaire
authors.initials: B
authors.lastname: Kapson
authors.affiliation: Stony Brook Department of Neurology, Stony Brook, NY.
authors.forename: Sumiti
authors.initials: S
authors.lastname: Nayar
authors.affiliation: Stony Brook Department of Neurology, Stony Brook, NY ; Stony Brook University Sleep Disorder Center, Stony Brook, NY.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Spiegel
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000188:drug therapy*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D000086:Acetazolamide
keywords: KLS; Kleine-Levine syndrome; acetazolamide; hypersomnolence; sleep disorder