title: Radiosynthesis of (11)C-Levetiracetam: A Potential Marker for PET Imaging of SV2A Expression.
abstract: The multistep preparation of (11)C-levetiracetam ((11)C-LEV) was carried out by a one-pot radiosynthesis with 8.3 ± 1.6% (n = 8) radiochemical yield in 50 ± 5.0 min. Briefly, the propionaldehyde was converted to propan-1-imine in situ as labeling precursor by incubation with ammonia. Without further separation, the imine was reacted with (11)C-HCN to form (11)C-aminonitrile. This crude was then reacted with 4-chlorobutyryl chloride and followed by hydrolysis to yield (11)C-LEV after purification by chiral high-performance liquid chromatography (HPLC). Both the radiochemical and enantiomeric purities of (11)C-LEV were >98%.
authors.affiliation: PET Center, Children's Hospital of Michigan, Detroit Medical Center , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States ; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States.
authors.forename: Hancheng
authors.initials: H
authors.lastname: Cai
authors.affiliation: PET Center, Children's Hospital of Michigan, Detroit Medical Center , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Mangner
authors.affiliation: PET Center, Children's Hospital of Michigan, Detroit Medical Center , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
authors.forename: Otto
authors.initials: O
authors.lastname: Muzik
authors.affiliation: Departments of Nuclear Medicine and Oncology, Fudan University Shanghai Cancer Center , Shanghai 200032, People's Republic of China ; Departments of Nuclear Medicine and Oncology, Fudan University Shanghai Cancer Center , Shanghai 200032, People's Republic of China.
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.affiliation: PET Center, Children's Hospital of Michigan, Detroit Medical Center , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
authors.forename: Diane C
authors.initials: DC
authors.lastname: Chugani
authors.affiliation: PET Center, Children's Hospital of Michigan, Detroit Medical Center , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States ; Departments of Pediatrics, Radiology, and Neurology, Wayne State University School of Medicine , Detroit, Michigan 48201, United States.
authors.forename: Harry T
authors.initials: HT
authors.lastname: Chugani
keywords: Levetiracetam; carbon-11; positron emission tomography; synaptic vesicle protein 2A