title: Endoplasmic reticulum stress and cancer.
abstract: The endoplasmic reticulum (ER) is the principal organelle responsible for multiple cellular functions including protein folding and maturation and the maintenance of cellular homeostasis. ER stress is activated by a variety of factors and triggers the unfolded protein response (UPR), which restores homeostasis or activates cell death. Multiple studies have clarified the link between ER stress and cancer, and particularly the involvement of the UPR. The UPR seems to adjust the paradoxical microenvironment of cancer and, as such, is one of resistance mechanisms against cancer therapy. This review describes the activity of different UPRs involved in tumorigenesis and resistance to cancer therapy.
authors.affiliation: Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Yadav
authors.affiliation: Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea.
authors.forename: Soo-Wan
authors.initials: SW
authors.lastname: Chae
authors.affiliation: Department of Dental Pharmacology, College of Dentistry, Wonkwang University, Iksan, Chonbuk, Korea.
authors.forename: Hyung-Ryong
authors.initials: HR
authors.lastname: Kim
authors.affiliation: Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Jeonju, Chonbuk, Korea.
authors.forename: Han Jung
authors.initials: HJ
authors.lastname: Chae
keywords: Cancer; Endoplasmic reticulum stress; Unfolded protein response