title: CpG-loaded multifunctional cationic nanohydrogel particles as self-adjuvanting glycopeptide antitumor vaccines.
abstract: Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.
authors.affiliation: Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128, Mainz, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Hartmann
authors.forename: Lutz
authors.initials: L
authors.lastname: Nuhn
authors.forename: Björn
authors.initials: B
authors.lastname: Palitzsch
authors.forename: Markus
authors.initials: M
authors.lastname: Glaffig
authors.forename: Natascha
authors.initials: N
authors.lastname: Stergiou
authors.forename: Bastian
authors.initials: B
authors.lastname: Gerlitzki
authors.forename: Edgar
authors.initials: E
authors.lastname: Schmitt
authors.forename: Horst
authors.initials: H
authors.lastname: Kunz
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zentel
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D002412:Cations; D004797:Enzyme-Linked Immunosorbent Assay; D006020:Glycopeptides / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: D000276:Adjuvants, Immunologic; C408982:CPG-oligonucleotide; D019496:Cancer Vaccines; D002412:Cations; D006020:Glycopeptides; D009838:Oligodeoxyribonucleotides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
keywords: CpG codelivery; MUC1 glycopeptide; anti-tumor vaccines; cationic nanohydrogels; self-adjuvanting vaccines