title: Clinicopathological characteristics of follicular lymphoma with peripheral blood involvement.
abstract: This study aimed to indicate patient outcomes and pathological characteristics of follicular lymphoma (FL) with peripheral blood (PB) involvement. Of 533 patients with FL, 56 (11%) had PB involvement. Of the patients treated with rituximab, 39 patients with PB involvement had significantly shorter progression-free survival than 107 patients with stage IV disease without PB involvement (p = 0.021), but the overall survival was not different (p = 0.804). The histopathology of the primary sites was usually nodal (95%) low-grade (86%) FL with IGH/BCL2 fusion (75%). Flow cytometric and immunohistochemical analyses revealed that the incidence of CD10 positivity was lower in the bone marrow (55% and 58%) and PB (41% and not available) than in the primary site (86% and 93%) (p = 0.004 and p = 0.0001, respectively). Therefore, even if small lymphoma cells in the bone marrow and PB are negative for CD10, FL cannot be ruled out.
authors.affiliation: Department of Pathology and Clinical Laboratory.
authors.forename: Akiko Miyagi
authors.initials: AM
authors.lastname: Maeshima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Kensaku
authors.initials: K
authors.lastname: Tanioka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kitahara
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Suguru
authors.initials: S
authors.lastname: Fukuhara
authors.forename: Wataru
authors.initials: W
authors.lastname: Munakata
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Dai
authors.initials: D
authors.lastname: Maruyama
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Kensei
authors.initials: K
authors.lastname: Tobinai
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kushima
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000473:pathology*; D008224:Lymphoma, Follicular / Q000097:blood* / Q000473:pathology*; D011379:Prognosis
keywords: CD10; Follicular lymphoma; leukemic phase; peripheral blood; rituximab