title: A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles.
abstract: An asymmetric cascade Mannich/cyclization reaction between 3-isothiocyanato oxindoles and sulfimides using a commercially available organocatalyst has been developed. A wide range of structurally diverse spiro[imidazolidine-4,3'-oxindole] derivatives were obtained with good yields (up to 92%) and excellent enantioselectivities (up to 99% ee).
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, P. R. China. jinyixu@china.com.
authors.forename: Hao
authors.initials: H
authors.lastname: Cai
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D000078183:Oxindoles; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C022960:2-oxindole