title: The physiological roles of secretin and its receptor.
abstract: Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. In addition to regulating the secretion of a number of epithelia (e.g., in the pancreas and biliary epithelium in the liver), secretin exerts trophic effects in several cell types. In this article, we will provide a comprehensive review on the multiple roles of secretin and SR signaling in the regulation of epithelial functions in various organ systems with particular emphasis in the liver. We will discuss the role of secretin and its receptor in health and biliary disease pathogenesis. Finally, we propose future areas of research for the further evaluation of the secretin/secretin receptor axis in liver pathophysiology.
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Syeda
authors.initials: S
authors.lastname: Afroze
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Fanyin
authors.initials: F
authors.lastname: Meng
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Kendal
authors.initials: K
authors.lastname: Jensen
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Kelly
authors.initials: K
authors.lastname: McDaniel
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Kinan
authors.initials: K
authors.lastname: Rahal
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Onori
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Gaudio
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Alpini
authors.affiliation: 1 Department of Medicine, Division Gastroenterology, 2 Research, Central Texas Veterans Health Care System, 3 Scott & White Digestive Disease Research Center, Scott & White, and Texas A&M Health Science Center, College of Medicine, Temple, TX 76504, USA ; 4 Experimental Medicine, University of L'Aquila, L'Aquila, Italy ; 5 Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, University Sapienza, Rome, Italy.
authors.forename: Shannon S
authors.initials: SS
authors.lastname: Glaser
keywords: Secretin; Secretin receptors