title: Long-term follow-up of 123 patients with adenocarcinoma of the sinonasal tract treated with endoscopic resection and postoperative radiation therapy.
abstract: BACKGROUND
  Most series about endoscopic resection of adenocarcinomas of the sinonasal tract present outcome data from a small heterogeneous group of patients with a relatively short follow-up period and a wide variety of histological subtypes and treatment protocols. This relatively large study with a very homogeneous study population updates our experience with a stable treatment protocol looking at survival rates, surgical technique, and prognostic factors.
  
  
  METHODS
  We conducted a retrospective analysis of the medical records of 123 patients with adenocarcinoma of the intestinal type primarily treated with endoscopic resection and postoperative radiotherapy (RT) in a single tertiary referral center during the period 1992 to 2010.
  
  
  RESULTS
  Mean follow-up was 66 months and median follow-up was 54 months. Mean and median follow-up of the subgroup of patients alive at the end of follow-up was 74 months and 61 months, respectively. At 5-years of follow-up, overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) were 68%, 82%, and 62% respectively. At 10-year follow-up, these numbers were 51%, 74%, and 45%, respectively. Prognostic factors for treatment outcome are predominantly local recurrence, development of distant metastasis, T classification, histopathological classification, and the center where the first surgery was performed.
  
  
  CONCLUSIONS
  This large study of sinonasal adenocarcinoma primarily treated with endoscopic resection and RT confirms that this approach results in good oncologic and functional outcome.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Camp
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Laura
authors.initials: L
authors.lastname: Van Gerven
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.|Department of Oncology, Section of Head and Neck Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Vincent Vander
authors.initials: VV
authors.lastname: Poorten
authors.affiliation: Department of Radiotherapy-Oncology, University Hospitals Leuven, Leuven, Belgium.|Department of Oncology, Section of Head and Neck Oncology, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Sandra
authors.initials: S
authors.lastname: Nuyts
authors.affiliation: Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Hermans
authors.affiliation: Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Esther
authors.initials: E
authors.lastname: Hauben
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
authors.forename: Mark
authors.initials: M
authors.lastname: Jorissen
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010255:Paranasal Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate
keywords: adenocarcinoma; craniofacial resection; endoscopic sinus surgery; paranasal sinus; radiotherapy