title: An overview of various mammalian models to study chronic copper intoxication associated Alzheimer's disease like pathology.
abstract: Chronic copper toxicity has been long known to cause hepatotoxicity and liver cirrhosis as observed in Wilson's disease; however, substantial evidence accrued over the time have shown considerable increase in animal studies demonstrating Alzheimer's disease like pathology due to chronic copper-intoxication under certain conditions. This review integrates the contemporary mammalian studies in which the effect of chronic copper intoxication was assessed on the central nervous system and cognition of animals.
authors.affiliation: Department of Biochemistry, PGIMER, Chandigarh, 160012, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Pal
authors.forename: Rajendra
authors.initials: R
authors.lastname: Prasad
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced* / Q000473:pathology*; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003300:Copper / Q000633:toxicity*; D004195:Disease Models, Animal; D008322:Mammals; D019636:Neurodegenerative Diseases / Q000139:chemically induced / Q000473:pathology
chemical_list: D003300:Copper