title: Contemporary concepts in the aetiopathogenesis of detrusor underactivity.
abstract: Detrusor underactivity (DUA) is a poorly understood, yet common, bladder dysfunction, referred to as underactive bladder, which is observed in both men and women undergoing urodynamic studies. Despite its prevalence, no effective therapeutic approaches exist for DUA. Exactly how the contractile function of the detrusor muscle changes with ageing is unclear. Data from physiological studies in animal and human bladders are contradictory, as are the results of the limited number of clinical studies assessing changes in urodynamic parameters with ageing. The prevalence of DUA in different patient groups suggests that multiple aetiologies are involved in DUA pathogenesis. Traditional concepts focused on either efferent innervation or myogenic dysfunction. By contrast, contemporary views emphasize the importance of the neural control mechanisms, particularly the afferent system, which can fail to potentiate detrusor contraction, leading to premature termination of the voiding reflex. In conclusion, the contemporary understanding of the aetiology and pathophysiology of DUA is limited. Further elucidation of the underlying mechanisms is needed to enable the development of new and effective treatment approaches.
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire S10 2JF, UK.
authors.forename: Nadir I
authors.initials: NI
authors.lastname: Osman
authors.affiliation: Department of Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield, South Yorkshire S10 2JF, UK.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Chapple
mesh_terms: D000344:Afferent Pathways / Q000503:physiopathology; D000375:Aging / Q000502:physiology*; D000818:Animals; D048909:Diabetes Complications / Q000150:complications; D006801:Humans; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000150:complications; D059348:Peripheral Nerve Injuries / Q000150:complications; D001743:Urinary Bladder / Q000294:innervation* / Q000503:physiopathology*; D001745:Urinary Bladder Diseases / Q000209:etiology* / Q000503:physiopathology*; D001748:Urinary Bladder Neck Obstruction / Q000150:complications; D014563:Urodynamics