title: Indication of Adequate Transdermal Fentanyl Dose in Opioid Switching From Oral Oxycodone in Patients With Cancer.
abstract: OBJECTIVE
  The present study aimed to examine affecting factors for conversion ratio and to predict adequate fentanyl dose for patients with cancer pain in opioid switching from oral oxycodone.
  
  
  METHODS
  Patient characteristics, biochemical parameters, daily oxycodone dose, and reasons for opioid switching were retrospectively collected. The effect of variables on the conversion ratio was analyzed by multiple regression analysis.
  
  
  RESULTS
  Regression analysis for the data from 122 patients suggested that the typical conversion ratio was 95:1; however, this ratio was significantly reduced in patients taking a daily oral morphine-equivalent dose of <45 mg/d and in patients with poor pain control to 52:1 and 64:1, respectively.
  
  
  CONCLUSIONS
  We should carefully and rapidly control pain in opioid switching based on the adequate dose indicated in this study.
authors.affiliation: Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan Department of Pharmacy, Osaka-fu Saiseikai Noe Hospital, Osaka, Japan chika-matsumura@mb.kyoto-phu.ac.jp.
authors.forename: Chikako
authors.initials: C
authors.lastname: Matsumura
authors.affiliation: Department of Pharmacy, Osaka-fu Saiseikai Noe Hospital, Osaka, Japan.
authors.forename: Masami
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: Saki
authors.initials: S
authors.lastname: Fujihara
authors.affiliation: Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: Yugo
authors.initials: Y
authors.lastname: Chisaki
authors.affiliation: Department of Pharmacy, Osaka-fu Saiseikai Noe Hospital, Osaka, Japan.
authors.forename: Kazushige
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Education and Research Center for Clinical Pharmacy, Kyoto Pharmaceutical University, Kyoto, Japan.
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Yano
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000627:therapeutic use; D015992:Body Mass Index; D000072716:Cancer Pain / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010098:Oxycodone / Q000008:administration & dosage* / Q000627:therapeutic use; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D012044:Regression Analysis; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D000701:Analgesics, Opioid; D010098:Oxycodone; D005283:Fentanyl
keywords: conversion ratio; opioid switching; oral oxycodone; pain control; patients with cancer; transdermal fentanyl