title: Octreotide-associated cholestasis and hepatitis in an infant with congenital hyperinsulinism.
abstract: Congenital hyperinsulinism (CHI) is the most common cause of prolonged hypoglycemia in the neonate. It is caused by several genetic mutations that interfere with the cascade of normal insulin secretion from pancreatic beta cells. Octreotide, a somatostatin analog, suppresses insulin secretion from pancreatic beta cells, and is an effective therapy used for both short and long term in the treatment of CHI. It is well tolerated in most patients; however, several adverse effects have been reported, most of them mild and transient. Impaired liver function has been described previously in few children. Here, we describe about a child with CHI treated with continuous intravenous octreotide who developed cholestasis and hepatitis after a short period of treatment. This combination of liver effects with a short duration of treatment has not been reported previously with octreotide use in this population.
authors.forename: Floris
authors.initials: F
authors.lastname: Levy-Khademi
authors.forename: Shchors
authors.initials: S
authors.lastname: Irina
authors.forename: Carmit
authors.initials: C
authors.lastname: Avnon-Ziv
authors.forename: Michal
authors.initials: M
authors.lastname: Levmore-Tamir
authors.forename: Oren
authors.initials: O
authors.lastname: Leder
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000235:genetics; D002779:Cholestasis / Q000139:chemically induced* / Q000175:diagnosis / Q000235:genetics; D044903:Congenital Hyperinsulinism / Q000188:drug therapy* / Q000235:genetics; D006505:Hepatitis / Q000235:genetics / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D020125:Mutation, Missense; D015282:Octreotide / Q000009:adverse effects* / Q000627:therapeutic use; D064233:Sulfonylurea Receptors / Q000235:genetics
chemical_list: C577507:ABCC8 protein, human; D064233:Sulfonylurea Receptors; D015282:Octreotide