title: Aza-Michael reaction of 12-N-carboxamide of (-)-cytisine under high pressure conditions.
abstract: The first example of aza-Michael reaction of 12-N-carboxamide of quinolizidine alkaloid (-)-cytisine with α,β-unsaturated ketones, dimethyl acetylenedicarboxylate and β-nitrostyrene under high pressure condition has been described. It has been shown that the [4+2]-cycloaddition takes place in the case with N-phenylmaleimide.
authors.affiliation: a Institute of Organic Chemistry, Ufa Scientific Center of the Russian Academy of Sciences , 71, pr. Oktyabrya, 450054 Ufa , Russian Federation.
authors.forename: Inna P
authors.initials: IP
authors.lastname: Tsypysheva
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Lobov
authors.forename: Alena V
authors.initials: AV
authors.lastname: Kovalskaya
authors.forename: Polina R
authors.initials: PR
authors.lastname: Petrova
authors.forename: Sergey P
authors.initials: SP
authors.lastname: Ivanov
authors.forename: Shamil A
authors.initials: SA
authors.lastname: Rameev
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Borisevich
authors.forename: Rustam L
authors.initials: RL
authors.lastname: Safiullin
authors.forename: Marat S
authors.initials: MS
authors.lastname: Yunusov
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry; D001392:Azocines / Q000138:chemical synthesis / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008301:Maleimides / Q000737:chemistry; D015394:Molecular Structure; D054837:Quinolizidines / Q000138:chemical synthesis / Q000737:chemistry*; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry; D000093843:Quinolizidine Alkaloids
chemical_list: D000470:Alkaloids; D000480:Alkynes; D001392:Azocines; D007659:Ketones; D008301:Maleimides; D054837:Quinolizidines; D011807:Quinolizines; D013343:Styrenes; C011955:beta-nitrostyrene; C004712:cytisine; D000093843:Quinolizidine Alkaloids; C022918:acetylenedicarboxylic acid dimethyl ester; C028525:N-phenylmaleimide
keywords: (–)-cytisine; aza-Michael reaction; high pressure