title: Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice.
abstract: Turmeric (Curcuma longa L., Zingiberaceae) has a long history of use in medicine for the treatment of inflammatory conditions. One of the major constituents of turmeric is curcumin (diferuloylmethane), which is responsible for its characteristic yellow color. In the present study, we have examined the chemoprotective effects of curcuminon dextran sulfate sodium (DSS)-induced mouse colitis. For this purpose, we pre-treated male ICR mice with curcumin (0.1 or 0.25 mmol/kg in 0.05% carboxymethyl cellulose) by gavage for a week and then co-treated the animals with curcumin by gavage and 3% DSS in drinking water for another 7 days. Our study revealed that administration of curcumin significantly attenuated the severity of DSS-induced colitis and STAT3 signaling in mouse colon. The levels of the cell cycle regulators CDK4 and cylinD1 were significantly reduced by curcumin administration. Moreover, the expression of p53, which is an upstream regulator of the CDK4-cylinD1 complex, was inhibited by curcumin treatment.
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul.
authors.forename: Joon-Yeop
authors.initials: JY
authors.lastname: Yang
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul.
authors.forename: Xiancai
authors.initials: X
authors.lastname: Zhong
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul.
authors.forename: Hye-Won
authors.initials: HW
authors.lastname: Yum
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul.
authors.forename: Hyung-Jun
authors.initials: HJ
authors.lastname: Lee
authors.affiliation: College of Pharmacy, Keimyung University, Daegu.
authors.forename: Joydeb Kumar
authors.initials: JK
authors.lastname: Kundu
authors.affiliation: Department of Food and Nutrition, Sungshin Women's University, Seoul, Korea.
authors.forename: Hye-Kyung
authors.initials: HK
authors.lastname: Na
authors.affiliation: Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul.
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Surh
keywords: Colitis; Curcumin; Dextran sulfate sodium; Mouse colon; STAT3