title: [Role of HRI in apoptosis resistance].
abstract: When exposed to environmental stresses, cells activate defence mechanisms to adapt stress and inhibit apoptotic pathways leading to their survival. Stressed cells also reduce their general metabolism in part by inhibiting mRNA translation, thereby saving energy needed to repair stress-induced damages. Under stress conditions, the inhibition of mRNA translation occurs mainly at its initiation step through the phosphorylation of the translation initiation factor eIF2α. One of the four kinases known to phosphorylate eIF2α is heme-regulated inhibitor (HRI). The activation of HRI occurs under conditions of heme deficiency, oxidative stress and treatment with anti-cancer drugs such as proteasome inhibitors. In this article, we discuss the role of HRI in promoting cell resistance to stress-mediated apoptosis.
authors.affiliation: Département de biologie moléculaire, biochimie médicale et pathologie, faculté de médecine, université Laval, CHU de Québec St-François d'Assise, 10, rue de l'Espinay, G1L 3L5 Québec, Canada.
authors.forename: France-Hélène
authors.initials: FH
authors.lastname: Joncas
authors.affiliation: Département de biologie moléculaire, biochimie médicale et pathologie, faculté de médecine, université Laval, CHU de Québec St-François d'Assise, 10, rue de l'Espinay, G1L 3L5 Québec, Canada.
authors.forename: Pauline
authors.initials: P
authors.lastname: Adjibade
authors.affiliation: Département de biologie moléculaire, biochimie médicale et pathologie, faculté de médecine, université Laval, CHU de Québec St-François d'Assise, 10, rue de l'Espinay, G1L 3L5 Québec, Canada.
authors.forename: Rachid
authors.initials: R
authors.lastname: Mazroui
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D003594:Cytoplasmic Granules / Q000378:metabolism; D004900:Erythroblasts / Q000502:physiology; D006418:Heme / Q000502:physiology; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology; D014176:Protein Biosynthesis / Q000235:genetics; D013312:Stress, Physiological / Q000502:physiology; D019892:eIF-2 Kinase / Q000502:physiology*
chemical_list: D006418:Heme; D019892:eIF-2 Kinase