title: Chiral discrimination of secondary alcohols and carboxylic acids by NMR spectroscopy.
abstract: The manuscript reports two novel ternary ion-pair complexes, which serve as chiral solvating agents, for enantiodiscrimination of secondary alcohols and carboxylic acids. The protocol for discrimination of secondary alcohols is designed by using one equivalent mixture each of enantiopure mandelic acid, 4-dimethylaminopyridine (DMAP) and a chiral alcohol. For discrimination of carboxylic acids, the ternary complex is obtained by one equivalent mixture each of enantiopure chiral alcohol, DMAP and a carboxylic acid. The designed protocols also permit accurate measurement of enantiomeric composition.
authors.affiliation: NMR Research Centre, Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, 560012, India.
authors.forename: Indrani
authors.initials: I
authors.lastname: Pal
authors.forename: Sachin R
authors.initials: SR
authors.lastname: Chaudhari
authors.forename: Nagaraja Rao
authors.initials: NR
authors.lastname: Suryaprakash
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D002264:Carboxylic Acids
keywords: NMR spectroscopy; carboxylic acids; chiral discrimination; enatiomeric excess