title: [Trans-intestinal cholesterol excretion (TICE): a new route for cholesterol excretion].
abstract: The small intestine plays a crucial role in dietary and biliary cholesterol absorption, as well as its lymphatic secretion as chylomicrons (lipoprotein exogenous way). Recently, a new metabolic pathway called TICE (trans-intestinal excretion of cholesterol) that plays a central role in cholesterol metabolism has emerged. TICE is an inducible way, complementary to the hepatobiliary pathway, allowing the elimination of the plasma cholesterol directly into the intestine lumen through the enterocytes. This pathway is poorly characterized but several molecular actors of TICE have been recently identified. Although it is a matter of debate, two independent studies suggest that TICE is involved in the anti-atherogenic reverse cholesterol transport pathway. Thus, TICE is an innovative drug target to reduce -cardiovascular diseases.
authors.affiliation: IRS-UN, institut du thorax, unité Inserm UMR 1087/CNRS UMR 6291, 8, quai Moncousu, 44007 Nantes Cedex 1, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Blanchard
authors.affiliation: IRS-UN, institut du thorax, unité Inserm UMR 1087/CNRS UMR 6291, 8, quai Moncousu, 44007 Nantes Cedex 1, France.
authors.forename: François
authors.initials: F
authors.lastname: Moreau
authors.affiliation: IRS-UN, institut du thorax, unité Inserm UMR 1087/CNRS UMR 6291, 8, quai Moncousu, 44007 Nantes Cedex 1, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Cariou
authors.affiliation: IRS-UN, institut du thorax, unité Inserm UMR 1087/CNRS UMR 6291, 8, quai Moncousu, 44007 Nantes Cedex 1, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Le May
mesh_terms: D000818:Animals; D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D066237:Intestinal Elimination; D007413:Intestinal Mucosa / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism
chemical_list: D008074:Lipoproteins; D002784:Cholesterol