title: Gaze maintenance and autism spectrum disorder.
abstract: Chase is a 5½-year-old boy whom you have followed in your primary care practice since age 26 months. He was born full-term vaginal delivery weighing 6 pounds 15 ounces. His biological mother used heroin, tobacco, and cocaine during pregnancy. From 8 weeks to 18 months, he spent time in a foster home where he was provided limited attention and nurturing. At age 18 months, he entered a loving foster home; at 26 months, he was adopted. There is maternal history of attention-deficit hyperactivity disorder, learning disability, depression, bipolar disorder, and substance abuse but no history of autism or cognitive disability. Chase received early intervention before adoption. Specific concerns are unknown. At the time of his adoption, he had delays in gross motor and fine motor skills, nonverbal communication, and speech production. Familiar listeners find Chase to be 100% intelligible but unfamiliar listeners understand about 70% of what Chase says. He enjoys being with his adopted mother and imitating her. He has demonstrated significant anxiety during his play therapy. He has difficulty in paying attention to multistep directions. Chase can point and wave but has difficulty following someone's eyes to see where another person is looking. Chase enjoys a variety of interests but has a special fixation on Toy Story characters. Chase does initiate social interactions but can be aggressive toward his siblings and oppositional toward his parents. He is not aggressive at school. Teachers note hyperactivity and impulsivity. Chase is bothered by bright lights and by others making loud noises but has no difficulty with crowds. Chase is reported to have difficulty in transitioning between activities. At his 5-year-old visit, you as well as his mother and therapists note that he has trouble following with his eyes so he is referred to a neuro-ophthalmologist. Evaluation showed Chase was able to fix on and follow objects and light, his peripheral vision was normal, his pupils were equal and reactive without afferent pupillary defect, and normal visual tracking as assessed through pursuit and saccades. There were some head jerking motions observed which were not thought to be part of Chase's attempts to view objects. Gaze impersistence was noted, although it was not clear if this was due to a lack of attention or a true inability to maintain a gaze in the direction instructed. On review of the school's speech and language report, they state that he is >90% intelligible. He has occasional lip trills. Testing with the Clinical Evaluation of Language Fundamentals shows mild delays in receptive language, especially those that require visual attention. Verbal Motor Production Assessment for Children reveals focal oromotor control and sequencing skills that are below average, with groping when asked to imitate single oromotor nonspeech movements and sequenced double oromotor nonspeech movements. At 5½ years, he returns for follow-up, and he is outgoing and imaginative, eager to play and socialize. He makes eye contact but does not always maintain it. He asks and responds to questions appropriately, and he is able to follow verbal directions and verbal redirection. He is very interested in Toy Story characters but willing to share them and plays with other toys. Chase's speech has predictable, easy to decode sound substitutions. On interview with him, you feel that he has borderline cognitive abilities. He also demonstrates good eye contact but lack of visual gaze maintenance; this is the opposite of the pattern you are accustomed to in patients with autism spectrum disorder. What do you do next?
authors.affiliation: *Department of Pediatrics, Hershey Medical Center Children's Hospital, Hershey, PA; †Penn State Hershey Medical Center Pediatric Therapy Services, Hershey, PA; ‡Section of Behavior and Developmental Pediatrics, Hershey Medical Center Children's Hospital, Hershey, PA; §Departments of Ophthalmology and Pediatrics, Hershey Medical Center Children's Hospital, Hershey, PA; ‖Division of Developmental and Behavioral Pediatrics, Boston Medical Center, Boston, MA.
authors.forename: Leah
authors.initials: L
authors.lastname: Kaye
authors.forename: Marie
authors.initials: M
authors.lastname: Kurtz
authors.forename: Cheryl
authors.initials: C
authors.lastname: Tierney
authors.forename: Ajay
authors.initials: A
authors.lastname: Soni
authors.forename: Marilyn
authors.initials: M
authors.lastname: Augustyn
mesh_terms: D000067877:Autism Spectrum Disorder / Q000503:physiopathology* / Q000523:psychology; D002675:Child, Preschool; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D008297:Male; D015835:Ocular Motility Disorders / Q000503:physiopathology*