title: Exploiting supramolecular synthons in designing gelators derived from multiple drugs.
abstract: A simple strategy for designing salt-based supramolecular gelators comprised of various nonsteroidal anti-inflammatory drugs (NSAIDs) and amantadine (AMN) (an antiviral drug) has been demonstrated using a supramolecular synthon approach. Single-crystal and powder X-ray diffraction established the existence of the well-studied gel-forming 1D supramolecular synthon, namely, primary ammonium monocarboxylate (PAM) synthon in all the salts. Remarkably five out of six salts were found to be capable of gelling methyl salicylate (MS)-an important ingredient in commercially available topical gels; one such selected biocompatible salt displayed an anti-inflammatory response in prostaglandin E2 (PGE2 ) assay, thereby indicating their plausible biomedical applications.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science (IACS), 2A and 2B, Raja S. C. Mullick Road, Jadavpur, Kolkata - 700032, West Bengal (India), Fax: (+91) 33-2473-2805.
authors.forename: Rajdip
authors.initials: R
authors.lastname: Roy
authors.forename: Jolly
authors.initials: J
authors.lastname: Deb
authors.forename: Siddhartha Sankar
authors.initials: SS
authors.lastname: Jana
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000547:Amantadine / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002460:Cell Line; D004008:Diclofenac / Q000737:chemistry / Q000494:pharmacology; D015232:Dinoprostone / Q000378:metabolism; D005782:Gels / Q000737:chemistry*; D007371:Interferon-gamma / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D012212:Rheology; D012459:Salicylates / Q000737:chemistry; D012492:Salts / Q000737:chemistry
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D005782:Gels; D008070:Lipopolysaccharides; D012459:Salicylates; D012492:Salts; D004008:Diclofenac; D007371:Interferon-gamma; D000547:Amantadine; D015232:Dinoprostone; C033069:methyl salicylate
keywords: LMWGS; crystal engineering; drug delivery; supramolecular gels; supramolecular synthons