title: Rapid assembly of heterocycle grafted macrocycles via tandem one-pot double 1,3-dipolar cycloaddition reaction.
abstract: Synthesis of triazole linked macrocycles grafted with glycospiroheterocycle was accomplished by stereo- and regioselective tandem double 1,3-dipolar cycloaddition (1,3-DC) reaction. By this method we could construct complex chiral macrocycles in good yields from the easily available starting materials and we could achieve the synthesis of two heterocyclic rings involving simultaneous formation of five bonds in one-pot reaction. The structures of the macrocycles were confirmed by spectroscopic methods and single crystal XRD.
authors.affiliation: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai-600025, Tamil Nadu, India. ragharaghunathan@yahoo.com.
authors.forename: R
authors.initials: R
authors.lastname: Prasanna
authors.forename: S
authors.initials: S
authors.lastname: Purushothaman
authors.forename: R
authors.initials: R
authors.lastname: Raghunathan