title: Clinicopathological features of an ascending colon mixed adenoneuroendocrine carcinoma with clinical serosal invasion.
abstract: Mixed adenoneuroendocrine carcinoma (MANEC) is exceedingly rare with a poor outcome. In this article, we reported a MANEC in a 68-year-old woman with a symptom of abdominal pain and distension. MANEC derived from the ascending colon with highly aggressive behavior. The diagnosis and distinguish of MANEC must base on histological findings and immunohistochemical findings. In this case, microscopic observation showed tumor cells were arranged in conglobate and nested by fibrous tissue with a visible cell atypia and mitotic. NEC-like and exocrine glandular cells were also been seen in a single neoplasm. MANEC tissues were immunopositive for CK, CK20, P53, CK7, CDX-2, Ki-67 (70%+), E-cad, CD56, CEA, Syn, villin and CgA, and immunonegative for CA125, NSE, ER and PR. Here, the patient was treated by surgical operation and was followed-up near 3 months, no local recurrence and distant metastasis.
authors.affiliation: Xinyuan Institute of Medicine and Biotechnology, College of Biological Sciences, Zhejiang Sci-Tech University Hangzhou 310018, China.
authors.forename: Xi-Jun
authors.initials: XJ
authors.lastname: Liu
authors.affiliation: Research Institute of Traditional Chinese Medicine, Guangdong Medical College 2 # Wenmingdong Road, Xiashan, Zhanjiang 524023, China.
authors.forename: Jin-Shan
authors.initials: JS
authors.lastname: Feng
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Xiang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Kong
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan, Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Ling-Mei
authors.initials: LM
authors.lastname: Wang
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Jin-Cheng
authors.initials: JC
authors.lastname: Zeng
authors.affiliation: Department of Pathology, Taiping People's Hospital of Dongguan, Dongguan Hospital Affiliated to Medical College of Jinan University Dongguan 523905, China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Liang
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003082:Colectomy; D003110:Colonic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology*; D009361:Neoplasm Invasiveness; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Mixed adenoneuroendocrine carcinoma; ascending colon; immunohistochemistry