title: Therapy related myelodysplasia/myeloproliferative neoplasia-unclassified with acute leukemic transformation following Paclitaxel and Carboplatin based chemotherapy in an ovarian cancer patient.
abstract: Alkylating agents used in chemotherapy are mutagenic and have strong leukemogenic potential. The most serious long term complication of chemotherapy is the development of secondary disease, particularly hematological malignancy; they have rarely been reported in the context of ovarian cancer treatment. We describe quite a rare occurrence of a myelodyplastic/myeloproliferative neoplasm, unclassified (MDS/MPN-U) with acute leukemic transformation and multiple cytogenetic abnormalities not usually found together as JAK2 V617F mutation, 5q- and 7q-deletion, after exposure to paclitaxel and carboplatin based chemotherapy in a patient treated for ovarian cancer. We should be aware of such complication whose prognosis is really poor.
authors.affiliation: Department of Haematology and Clinical Pathology, Apollo Hospitals, Jubilee Hills, Hyderabad, 500096 India.
authors.forename: S
authors.initials: S
authors.lastname: Vanajakshi
authors.affiliation: Department of Oncology, Apollo Hospitals, Hyderabad, India.
authors.forename: S V S S
authors.initials: SV
authors.lastname: Prasad
authors.affiliation: Department of Haematology and Clinical Pathology, Apollo Hospitals, Jubilee Hills, Hyderabad, 500096 India.
authors.forename: S S
authors.initials: SS
authors.lastname: Amina
authors.affiliation: Department of Cytogenetics & Molecular Biology, Apollo Hospitals, Hyderabad, India.
authors.forename: E
authors.initials: E
authors.lastname: Kavitha
authors.affiliation: Department of Cytogenetics & Molecular Biology, Apollo Hospitals, Hyderabad, India.
authors.forename: K
authors.initials: K
authors.lastname: Iravathy Goud
authors.affiliation: Department of Haematology and Clinical Pathology, Apollo Hospitals, Jubilee Hills, Hyderabad, 500096 India.
authors.forename: K
authors.initials: K
authors.lastname: Kshitija