title: 8/8 and 10/10 high-resolution match rate for the be the match unrelated donor registry.
abstract: The National Marrow Donor Program's Be The Match Registry(®) facilitates the worldwide utilization of unrelated donor (URD) grafts for patients in need of a hematopoietic cell transplantation. In this study, we estimate the URD match rate for patients of White (WH), Hispanic (HIS), Asian/Pacific Islander (API), and African American/Black (AFA) race and ethnic groups. We chose 1344 URD at random as "pseudo-patients" (PP) to estimate the likelihood of finding an 8/8 or 10/10 high-resolution HLA-A,-B,-C,-DRB1 (and -DQB1) matched URD. Searches were conducted in the Be The Match Registry database for each PP at 2 time points: 2009 and 2012. URD who were a potential match for a PP by low/intermediate resolution were HLA typed by sequence-based typing to resolve the matching status. The 8/8 match rate for WH PP improved from 68% in 2009 to 72% in 2012. Corresponding match rates were 41% to 44% for HIS, 44% to 46% for API, and 27% to 30% for AFA, for 2009 and 2012, respectively. The 2012 10/10 match rates were 67% for WH, 38% for HIS, 41% for API, and 23% for AFA. These results provide baseline 8/8 and 10/10 match rate estimates by race for patients seeking an URD.
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota. Electronic address: jdehn@nmdp.org.
authors.forename: Jason
authors.initials: J
authors.lastname: Dehn
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Kelly
authors.initials: K
authors.lastname: Buck
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Martin
authors.initials: M
authors.lastname: Maiers
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Dennis
authors.initials: D
authors.lastname: Confer
authors.affiliation: C.W. Bill Young Marrow Donor Recruitment and Research Program, Department of Defense Marrow Donor Program, Bone Marrow Research Directorate, Naval Medical Research Center, Department of the Navy, Washington, District of Columbia.
authors.forename: Robert
authors.initials: R
authors.lastname: Hartzman
authors.affiliation: Jaeb Center for Health Research, Tampa, Florida.
authors.forename: Craig
authors.initials: C
authors.lastname: Kollman
authors.affiliation: DKMS German Bone Marrow Donor Center, Tübingen, Germany.
authors.forename: Alexander H
authors.initials: AH
authors.lastname: Schmidt
authors.affiliation: HistoGenetics LLC, Ossining, New York.
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Yang
authors.affiliation: National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Michelle
authors.initials: M
authors.lastname: Setterholm
mesh_terms: D044466:Asian People; D044383:Black People; D001853:Bone Marrow / Q000276:immunology / Q000378:metabolism*; D016026:Bone Marrow Transplantation; D016208:Databases, Factual; D015870:Gene Expression; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006630:Hispanic or Latino; D006650:Histocompatibility Testing; D006801:Humans; D012042:Registries; D061349:Unrelated Donors; D044465:White People; D001741:Black or African American
chemical_list: D006680:HLA Antigens
keywords: Allogeneic; Donor registry; HLA matching; Marrow and stem cell transplantation; Racial disparity