title: Arterial blood pressure as a predictor of the response to fluid administration in euvolemic nonhypotensive or hypotensive isoflurane-anesthetized dogs.
abstract: OBJECTIVE
  To determine the effects of rapid small-volume fluid administration on arterial blood pressure measurements and associated hemodynamic variables in isoflurane-anesthetized euvolemic dogs with or without experimentally induced hypotension.
  
  
  METHODS
  Prospective, randomized, controlled study.
  
  
  METHODS
  13 healthy dogs.
  
  
  METHODS
  Isoflurane-anesthetized dogs were randomly assigned to conditions of nonhypotension or hypotension (mean arterial blood pressure, 45 to 50 mm Hg) and treatment with lactated Ringer's solution (LRS) or hetastarch (3 or 10 mL/kg [1.4 or 4.5 mL/lb] dose in a 5-minute period or 3 mL/kg dose in a 1-minute period [4 or 5 dogs/treatment; ≥ 10-day interval between treatments]). Hemodynamic variables were recorded before and for up to 45 minutes after fluid administration.
  
  
  RESULTS
  IV administration of 10 mL/kg doses of LRS or hetastarch in a 5-minute period increased right atrial and pulmonary arterial pressures and cardiac output (CO) when dogs were nonhypotensive or hypotensive, compared with findings before fluid administration; durations of these effects were greater after hetastarch administration. Intravenous administration of 3 mL of hetastarch/kg in a 5-minute period resulted in an increase in CO when dogs were nonhypotensive. Intravenous administration of 3 mL/kg doses of LRS or hetastarch in a 1-minute period increased right atrial pressure and CO when dogs were nonhypotensive or hypotensive.
  
  
  CONCLUSIONS
  Administration of LRS or hetastarch (3 or 10 mL/kg dose in a 5-minute period or 3 mL/kg dose in a 1-minute period) improved CO in isoflurane-anesthetized euvolemic dogs with or without hypotension. Overall, arterial blood pressure measurements were a poor predictor of the hemodynamic response to fluid administration.
authors.affiliation: QTest Labs, 6456 Fiesta Dr, Columbus, OH 43235.
authors.forename: William W
authors.initials: WW
authors.lastname: Muir
authors.forename: Yukie
authors.initials: Y
authors.lastname: Ueyama
authors.forename: Adriana
authors.initials: A
authors.lastname: Pedraza-Toscano
authors.forename: Pedro
authors.initials: P
authors.lastname: Vargas-Pinto
authors.forename: Carlos L
authors.initials: CL
authors.lastname: Delrio
authors.forename: Robert S
authors.initials: RS
authors.lastname: George
authors.forename: Bradley L
authors.initials: BL
authors.lastname: Youngblood
authors.forename: Robert L
authors.initials: RL
authors.lastname: Hamlin
mesh_terms: D018685:Anesthetics, Inhalation / Q000009:adverse effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004283:Dog Diseases / Q000188:drug therapy; D004285:Dogs; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage / Q000494:pharmacology*; D007022:Hypotension / Q000628:therapy / Q000662:veterinary*; D007530:Isoflurane / Q000009:adverse effects* / Q000494:pharmacology; D007552:Isotonic Solutions / Q000494:pharmacology*; D010952:Plasma Substitutes / Q000008:administration & dosage / Q000627:therapeutic use; D000077331:Ringer's Solution
chemical_list: D018685:Anesthetics, Inhalation; D006895:Hydroxyethyl Starch Derivatives; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D000077331:Ringer's Solution; D007530:Isoflurane