title: [Long term follow-up and prognostic analysis of 85 cases with primary gastrointestinal diffuse large B cell lymphoma].
abstract: OBJECTIVE
  To analyze the clinical characteristics, prognostic factors in patients with primary gastrointestinal diffuse large B cell lymphoma (PGI-DLBCL).
  
  
  METHODS
  Long term follow-up of 85 patients with PGI-DLBCL was carried out and the patients clinical data were retrospectively evaluated. The risk factors for survival rate were analyzed by univariate and multivariate Cox regression analysis.
  
  
  RESULTS
  The median age of 85 patients was 61 years old (18-87), and male: female ratio was 1.83:1 (55/30). The stomach origin accounted for 63.5% (54/85), intestine origin for 35.3% (30/85) and multiple GI involvements for 1.2% (1/85). Bone marrow involvement accounted for 16.4% (11/64), Helicobacter pylori (HP) infection for 51.4% (19/37). The 5-year overall survival (OS) rates of all patients were 63.9%. The 5-year OS of patients in stomach and intestinal groups were 75.3% and 44.1%, respectively (P=0.005). The 5-year OS of germinal center B cell-like (GCB) group and non-GCB groups were 64.7% and 62.4%, respectively (P = 0.610). Univariated analysis revealed that the factors affecting OS of patients included age, lesion site, tumor size, gastrointestinal clinical Lugano staging system, IPI score (all P values < 0.05). Multivariate Cox regression analysis revealed that IPI score was independent prognosis risk factor affecting OS (RR = 3.609, 95 CI 2.034-6.404, P < 0.01).
  
  
  CONCLUSIONS
  IPI score was independent prognosis risk factor affecting OS of PGI-DLBCL patients.
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Li'na
authors.initials: L
authors.lastname: Song
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Xinan
authors.initials: X
authors.lastname: Cen
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Jinping
authors.initials: J
authors.lastname: Ou
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Wensheng
authors.initials: W
authors.lastname: Wang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Qiu
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Song
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Zeyin
authors.initials: Z
authors.lastname: Liang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Xu
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Mangju
authors.initials: M
authors.lastname: Wang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Lihong
authors.initials: L
authors.lastname: Wang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Yin
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Sun
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The First Hospital, Peking University, Beijing 100034, China.
authors.forename: Hanyun
authors.initials: H
authors.lastname: Ren
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis*; D016481:Helicobacter Infections; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult