title: Intraindividual variation in core microbiota in peri-implantitis and periodontitis.
abstract: The oral microbiota change dramatically with each part of the oral cavity, even within the same mouth. Nevertheless, the microbiota associated with peri-implantitis and periodontitis have been considered the same. To improve our knowledge of the different communities of complex oral microbiota, we compared the microbial features between peri-implantitis and periodontitis in 20 patients with both diseases. Although the clinical symptoms of peri-implantitis were similar to those of periodontitis, the core microbiota of the diseases differed. Correlation analysis revealed the specific microbial co-occurrence patterns and found some of the species were associated with the clinical parameters in a disease-specific manner. The proportion of Prevotella nigrescens was significantly higher in peri-implantitis than in periodontitis, while the proportions of Peptostreptococcaceae sp. and Desulfomicrobium orale were significantly higher in periodontitis than in peri-implantitis. The severity of the peri-implantitis was also species-associated, including with an uncultured Treponema sp. that correlated to 4 clinical parameters. These results indicate that peri-implantitis and periodontitis are both polymicrobial infections with different causative pathogens. Our study provides a framework for the ecologically different bacterial communities between peri-implantitis and periodontitis, and it will be useful for further studies to understand the complex microbiota and pathogenic mechanisms of oral polymicrobial diseases.
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Noriko
authors.initials: N
authors.lastname: Maruyama
authors.affiliation: Department of Microbiology, Graduate School of Medicine, Kyoto University.
authors.forename: Fumito
authors.initials: F
authors.lastname: Maruyama
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takeuchi
authors.affiliation: Department of Microbiology, Graduate School of Medicine, Kyoto University.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Aikawa
authors.affiliation: Department of Periodontology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Izumi
authors.affiliation: Department of Microbiology, Graduate School of Medicine, Kyoto University.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nakagawa
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D064307:Microbiota / Q000235:genetics*; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology / Q000473:pathology; D010462:Peptostreptococcus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D057873:Peri-Implantitis / Q000235:genetics / Q000382:microbiology* / Q000473:pathology; D010518:Periodontitis / Q000235:genetics / Q000382:microbiology* / Q000473:pathology