title: Clinical and histopathological studies using fibrin-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw.
abstract: The authors report their experience using platelet-rich fibrin (PRF) therapy for the treatment of ten patients presenting bisphosphonate-related osteonecrosis of the jaw (BRONJ). The aim of our study was to evaluate the effect of this therapy on recurrent BRONJ and to describe the clinical and histopathological/immunohistochemical staining features of PRF treatment. As such, we describe the method we used and report the results observed in the areas treated as well as side effects. The reported results recommend the safety and efficacy of PRF in treatment of BRONJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; crystalvladan@gmail.com.
authors.forename: Octavian
authors.initials: O
authors.lastname: Dincă
authors.forename: Sabina
authors.initials: S
authors.lastname: Zurac
authors.forename: Florica
authors.initials: F
authors.lastname: Stăniceanu
authors.forename: Mihai Bogdan
authors.initials: MB
authors.lastname: Bucur
authors.forename: Dana Cristina
authors.initials: DC
authors.lastname: Bodnar
authors.forename: Cristian
authors.initials: C
authors.lastname: Vlădan
authors.forename: Alexandru
authors.initials: A
authors.lastname: Bucur
mesh_terms: D000328:Adult; D000368:Aged; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D005337:Fibrin