title: [Platelet rich plasma versus oral paracetamol for the treatment of early knee osteoarthritis. Preliminary study].
abstract: BACKGROUND
  in the treatment of early osteoartrosis, analgesics and non-steroidal anti-inflammatory drugs are frequently used to relieve pain. Currently, platelet rich plasma is used as an alternative in the treatment of osteoartrosis. The aim of this study was to evaluate the effect of platelet rich plasma compared to paracetamol as a treatment for patients with knee osteoartrosis grade I.
  
  
  METHODS
  we evaluated 42 patients who were randomized into two groups. Group one was treated with 5 mL of platelet rich plasma in two applications, while group two was treated with 1 gr of oral paracetamol every 8 hours for 30 days. Both patient groups received supervised physical rehabilitation during the 6 month observation period. Peripheral blood samples were taken to measure plasma IL-1β, TNF-a and TGF-β1 levels at day 0 and at 6 months post-treatment. Clinical evaluation was conducted using the KOOS at the start of the study and for every subsequent month during the study period.
  
  
  RESULTS
  the Knee injury and Osteoarthritis Outcome Score (KOOS) for group one at the start of the treatment was measured at 30.1 points, whereas at the end, it was measured at 48.2 points, showing a clinical improvement of 60%. There were no statistically significant differences in IL-1β and TNF-a levels between groups treated either with platelet rich plasma or paracetamol.
  
  
  CONCLUSIONS
  Our patients treated with platelet rich plasma showed a statistically significant increase in the serum levels of TGF-β1, which was associated with an improvement in the clinical evaluation used (KOOS).
authors.affiliation: Departamento de Ortopedia y Traumatología, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico. dr.carlosacosta@gmail.com.
authors.forename: Carlos
authors.initials: C
authors.lastname: Acosta-Olivo
authors.affiliation: Departamento de Ortopedia y Traumatología, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico.
authors.forename: Francisco
authors.initials: F
authors.lastname: Esponda-Colmenares
authors.affiliation: Departamento de Ortopedia y Traumatología, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico.
authors.forename: Félix
authors.initials: F
authors.lastname: Vilchez-Cavazos
authors.affiliation: Banco de Hueso y Tejidos, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Lara-Arias
authors.affiliation: Departamento de Ortopedia y Traumatología, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico.
authors.forename: Oscar
authors.initials: O
authors.lastname: Mendoza-Lemus
authors.affiliation: Departamento de Ortopedia y Traumatología, Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León. Monterrey, NL, Mexico.
authors.forename: Tomas
authors.initials: T
authors.lastname: Ramos-Morales
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D015415:Biomarkers; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000188:drug therapy / Q000534:rehabilitation / Q000628:therapy*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D053773:Transforming Growth Factor beta1 / Q000097:blood; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D015415:Biomarkers; D053583:Interleukin-1beta; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D000082:Acetaminophen
keywords: KOOS; Knee osteoarthritis; factores de crecimiento; growth factors; osteoartrosis de rodilla; plasma rico en plaquetas; platelet rich plasma