title: Correlation of PROMIS scales and clinical measures among chronic obstructive pulmonary disease patients with and without exacerbations.
abstract: OBJECTIVE
  The Patient-Reported Outcomes Measurement Information System (PROMIS(®)) initiative was developed to advance the methodology of PROs applicable to chronic diseases. Chronic obstructive pulmonary disease (COPD) is a progressive chronic disease associated with poor health. This study was designed to examine the correlation of PROMIS health-related quality of life (HRQOL) scales and clinical measures among COPD patients.
  
  
  METHODS
  A cross-sectional analysis was conducted comparing patients who were stable (n = 100) with those currently experiencing a COPD exacerbation (n = 85). All PROMIS measures for adults available at the time of the study (2008), disease-targeted and other HRQOL instruments, health literacy, percent predicted FEV1, and a 6-min walk distance were assessed when patients were considered clinically stable.
  
  
  RESULTS
  Stable COPD patients reported significantly (p ≤ 0.05) better health-related quality of life on PROMIS domains than patients experiencing an exacerbation. PROMIS domain scores were significantly (p ≤ 0.01) correlated with each of legacy measures. Six-min walk scores were most highly correlated with the PROMIS physical function domain scores (r = 0.53) followed by the fatigue (r = -0.26), social (r = 0.24) and to a lesser extent depression (r = -0.23), and anxiety (r = -0.22) domain scores. Percent predicted FEV1 score was significantly associated with PROMIS physical function scores (r = 0.27).
  
  
  CONCLUSIONS
  This study provides support for the validity of the PROMIS measures in COPD patients.
authors.affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC, 27599, USA, dirwin@email.unc.edu.
authors.forename: Debra E
authors.initials: DE
authors.lastname: Irwin
authors.forename: Charles A
authors.initials: CA
authors.lastname: Atwood
authors.forename: Ron D
authors.initials: RD
authors.lastname: Hays
authors.forename: Karen
authors.initials: K
authors.lastname: Spritzer
authors.forename: Honghu
authors.initials: H
authors.lastname: Liu
authors.forename: James F
authors.initials: JF
authors.lastname: Donohue
authors.forename: Nancy Kline
authors.initials: NK
authors.lastname: Leidy
authors.forename: Susan E
authors.initials: SE
authors.lastname: Yount
authors.forename: Darren A
authors.initials: DA
authors.lastname: DeWalt
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000523:psychology; D018450:Disease Progression; D005221:Fatigue / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063868:Patient Outcome Assessment; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology* / Q000523:psychology*; D011788:Quality of Life; D057566:Self Report