title: Feasibility and outcomes of combined transcatheter aortic valve replacement with other structural heart interventions in a single session: a matched cohort study.
abstract: Concurrent cardiac diseases are frequent among elderly patients and invite simultaneous treatment to ensure an overall favourable patient outcome.
  
  
  
  To investigate the feasibility of combined single-session percutaneous cardiac interventions in the era of transcatheter aortic valve implantation (TAVI).
  
  
  
  This prospective, case-control study included 10 consecutive patients treated with TAVI, left atrial appendage occlusion and percutaneous coronary interventions. Some in addition had patent foramen ovale or atrial septal defect closure in the same session. The patients were matched in a 1:10 manner with TAVI-only cases treated within the same time period at the same institution regarding their baseline factors. The outcome was validated according to the Valve Academic Research Consortium (VARC) criteria.
  
  
  
  Procedural time (126±42 vs 83±40 min, p=0.0016), radiation time (34±8 vs 22±12 min, p=0.0001) and contrast dye (397±89 vs 250±105 mL, p<0.0001) were higher in the combined intervention group than in the TAVI-only group. Despite these drawbacks, no difference in the VARC endpoints was evident during the in-hospital period and after 30 days (VARC combined safety endpoint 32% for TAVI only and 20% for combined intervention, p=1.0).
  
  
  
  Transcatheter treatment of combined cardiac diseases is feasible even in a single session in a high-volume centre with experienced operators.
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Khattab
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Steffen
authors.initials: S
authors.lastname: Gloekler
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Beate
authors.initials: B
authors.lastname: Sprecher
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Samera
authors.initials: S
authors.lastname: Shakir
authors.affiliation: Centro de Cardiopatias Congênitas e Estruturais do Paraná , Curitiba, Paraná , Brazil.
authors.forename: Enio
authors.initials: E
authors.lastname: Guerios
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Stortecky
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Crochan J
authors.initials: CJ
authors.lastname: O'Sullivan
authors.affiliation: Department of Cardiology , Zurich University Hospital , Zürich , Switzerland.
authors.forename: Fabian
authors.initials: F
authors.lastname: Nietlispach
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Aris
authors.initials: A
authors.lastname: Moschovitis
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pilgrim
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Lutz
authors.initials: L
authors.lastname: Buellesfeld
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Peter
authors.initials: P
authors.lastname: Wenaweser
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.affiliation: Cardiology, Cardiovascular Department , Bern University Hospital , Bern , Switzerland.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Meier