title: Seventy years of pancreatic physiology: take a look back.
abstract: This review article has 4 major objectives to follow pancreatic physiology development more than close to 70 years of intensive and productive basic research. At first, the review will focus on secretion of the pancreatic enzymes with (1) the controls involved, (2) the interrelations existing between secretion and synthesis of these enzymes, (3) the enzymes' adaptation to the constituents of the diet, and (4) whether secretion of the different enzymes is parallel or nonparallel. Second, growth and regeneration of the pancreatic gland will be looked at in relation to the factors involved and the target cells implicated.
authors.affiliation: From the Faculté de Médecine, Département de Médecine, Université de Sherbrooke, Sherbrooke, Québec, Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Morisset
mesh_terms: D000818:Animals; D018678:Cholinergic Agents / Q000494:pharmacology; D002918:Chymotrypsin / Q000096:biosynthesis / Q000378:metabolism; D004032:Diet; D004790:Enzyme Induction; D005762:Gastroenterology / Q000266:history*; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D006728:Hormones / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D023421:Models, Animal; D008954:Models, Biological; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology; D010179:Pancreas / Q000201:enzymology / Q000294:innervation / Q000502:physiology*; D010180:Pancreatectomy; D010196:Pancreatic Elastase / Q000096:biosynthesis / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010195:Pancreatitis / Q000503:physiopathology; D010827:Physiology / Q000266:history* / Q000379:methods; D012038:Regeneration; D012636:Secretory Rate / Q000187:drug effects; D014357:Trypsin / Q000096:biosynthesis / Q000378:metabolism
chemical_list: D018678:Cholinergic Agents; D005938:Glucocorticoids; D006728:Hormones; D009479:Neuropeptides; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin