title: Glycosylated star polypeptides from NCA polymerization: selective binding as a function of degree of branching and glycosylation.
abstract: Star-shaped polypeptides were synthesized via N-carboxyanhydride (NCA) polymerization initiated from various generations of PPI dendrimers. Molecular weight, arm length, and arm density were readily controlled to afford a series of star-shaped poly(glutamic acid) derivatives. Glycosylation of star-shaped poly(glutamic acid) resulted in the formation of a diverse range of glycopolypeptide architectures with tuneable degree of sugar conjugation. The secondary structure of the branched glycopolypeptides was studied as a function of the degree glycosylation. The bioactivity of the described glycopoly-peptides toward the lectin ConA was investigated and was shown to be architecture dependent.
authors.affiliation: School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
authors.forename: Mark
authors.initials: M
authors.lastname: Byrne
authors.forename: Robert
authors.initials: R
authors.lastname: Mildner
authors.forename: Henning
authors.initials: H
authors.lastname: Menzel
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D006031:Glycosylation; D006868:Hydrolysis; D037102:Lectins; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D050997:Nanomedicine / Q000379:methods* / Q000639:trends; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000737:chemistry; D011485:Protein Binding; D017433:Protein Structure, Secondary
chemical_list: D000812:Anhydrides; D050091:Dendrimers; D037102:Lectins; D010455:Peptides; D011099:Polyglutamic Acid
keywords: NCA polymerization; glycosylation; lectin binding; star polypeptides; structure property relation