title: FhSPECT-US guided needle biopsy of sentinel lymph nodes in the axilla: is it feasible?
abstract: Until now, core needle biopsy of the axillary sentinel lymph nodes in early stage breast cancer patients is not possible, due to the lack of a proper combination of functional and anatomical information. In this work we present the first fully 3D freehand SPECT--ultrasound fusion, combining the advantages of both modalities. By using spatial positioning either with optical or with electromagnetic tracking for the ultrasound probe, and a mini gamma camera as radiation detector for freehand SPECT reconstructions, we investigate the capability of the introduced multi-model imaging system, where we compare both 3D freehand SPECT and 3D ultrasound to ground truth for a realistic breast mimicking phantom and further analyze the effect of tissue deformation by ultrasound. Finally, we also show its application in a real clinical setting.
authors.forename: Aslı
authors.initials: A
authors.lastname: Okur
authors.forename: Christoph
authors.initials: C
authors.lastname: Hennersperger
authors.forename: Brent
authors.initials: B
authors.lastname: Runyan
authors.forename: José
authors.initials: J
authors.lastname: Gardiazaball
authors.forename: Matthias
authors.initials: M
authors.lastname: Keicher
authors.forename: Stefan
authors.initials: S
authors.lastname: Paepke
authors.forename: Thomas
authors.initials: T
authors.lastname: Wendler
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
mesh_terms: D001365:Axilla / Q000000981:diagnostic imaging / Q000473:pathology; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration / Q000379:methods*; D005240:Feasibility Studies; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology*; D064847:Multimodal Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*