title: The new polio eradication end game: rationale and supporting evidence.
abstract: Polio eradication requires the removal of all polioviruses from human populations, whether wild poliovirus or those emanating from the oral poliovirus vaccine (OPV). The Polio Eradication & Endgame Strategic Plan 2013-2018 provides a framework for interruption of wild poliovirus transmission in remaining endemic foci and lays out a plan for the new polio end game, which includes the withdrawal of Sabin strains, starting with type 2, and the introduction of inactivated poliovirus vaccine, for risk mitigation purposes. This report summarizes the rationale and evidence that supports the policy decision to switch from trivalent OPV to bivalent OPV and to introduce 1 dose of inactivated poliovirus vaccine into routine immunization schedules, and it describes the proposed implementation of this policy in countries using trivalent OPV.
authors.affiliation: Polio Eradication & Emergency Cluster (PEC), World Health Organization, Geneva, Switzerland.
authors.forename: Roland W
authors.initials: RW
authors.lastname: Sutter
authors.affiliation: Polio Eradication & Emergency Cluster (PEC), World Health Organization, Geneva, Switzerland.
authors.forename: Lauren
authors.initials: L
authors.lastname: Platt
authors.affiliation: Polio Eradication & Emergency Cluster (PEC), World Health Organization, Geneva, Switzerland.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Mach
authors.affiliation: Polio Eradication & Emergency Cluster (PEC), World Health Organization, Geneva, Switzerland.
authors.forename: Hamid
authors.initials: H
authors.lastname: Jafari
authors.affiliation: Polio Eradication & Emergency Cluster (PEC), World Health Organization, Geneva, Switzerland.
authors.forename: R Bruce
authors.initials: RB
authors.lastname: Aylward
mesh_terms: D060740:Disease Eradication / Q000379:methods* / Q000458:organization & administration*; D014943:Global Health; D006801:Humans; D011051:Poliomyelitis / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission; D023321:Poliovirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D014611:Vaccination / Q000379:methods*
chemical_list: D023321:Poliovirus Vaccines
keywords: eradication; poliomyelitis; vaccination