title: Design and characterisation of a polyethylene oxide matrix with the potential use as a teat insert for prevention/treatment of bovine mastitis.
abstract: This manuscript reports (for the first time) on antibiotic-free polymeric inserts for the prevention and/or treatment of bovine mastitis. Polyethylene oxide (PEO)-based inserts were prepared using different concentrations of various hydrophilic polymers and water-soluble and water-insoluble drug-release-modifying excipients. A simple and scalable melt-extrusion method was employed to prepare the inserts. The prepared inserts were characterised for their dimension, rheological and mechanical properties. The in vitro release of a model bacteriostatic drug (salicylic acid) from the prepared inserts was studied to demonstrate the effectiveness and reproducibility of the melt-extrusion manufacturing method. Further, the in vitro stability of the inserts was evaluated using gel permeation chromatography (GPC) to monitor any change in molecular weight under real-time and accelerated storage conditions. The investigated inserts were stable at accelerated storage conditions over a period of 6 months. PEO inserts have the potential to serve a dual purpose, act as a physical barrier against pathogens invading the teat canal of cows and possibly control the release of a drug.
authors.affiliation: Faculty of Medical and Health Sciences, School of Pharmacy, The University of Auckland, Auckland, New Zealand.
authors.forename: Sushila
authors.initials: S
authors.lastname: Bhattarai
authors.forename: Raid G
authors.initials: RG
authors.lastname: Alany
authors.forename: Craig R
authors.initials: CR
authors.lastname: Bunt
authors.forename: Hamdy
authors.initials: H
authors.lastname: Abdelkader
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Rathbone
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D002417:Cattle; D002850:Chromatography, Gel; D003692:Delayed-Action Preparations; D065546:Drug Liberation; D004355:Drug Stability; D004356:Drug Storage; D005079:Excipients / Q000737:chemistry*; D005260:Female; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000517:prevention & control; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D015203:Reproducibility of Results; D012212:Rheology; D020156:Salicylic Acid / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013997:Time Factors
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D011108:Polymers; D011092:Polyethylene Glycols; D020156:Salicylic Acid