title: Ocular Inflammation: Can It Be a Sign of Activity of Weber-Christian Disease? A Case Report and Review of Literature.
abstract: OBJECTIVE
  To present a case of Weber-Christian disease with symptomatic ocular involvment. Weber-Christian disease is a relapsing febrile nodular nonsuppurative panniculitis. It is characterized by malaise and fever accompanied by subcutaneous inflammatory nodules on the trunk and extremities. It can affect several organs, but ocular signs have been infrequently described in literature.
  
  
  METHODS
  A 20-year-old woman with Weber-Christian disease presented with severe bilateral ocular inflammation. A complete ophthalmologic examination was performed.
  
  
  RESULTS
  Visual acuity was 20/100 in both eyes and slit-lamp examination showed bilateral iridocyclitis. Bilateral cortico-nuclear cataract did not allow funduscopy and she underwent cataract extraction. Retinal vasculitis was detected.
  
  
  CONCLUSIONS
  Patients with Weber-Christian disease can develop severe ocular inflammation. A complete ophthalmolgic examination should be done in these patients, especially when ocular involvement is the main sign of the disease. A further understanding of the severity of ocular inflammation proved fundamental in the management of the disease.
authors.affiliation: a Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy .
authors.forename: Sara
authors.initials: S
authors.lastname: Verrilli
authors.affiliation: a Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy .
authors.forename: Angela
authors.initials: A
authors.lastname: Ciarnella
authors.affiliation: b Immunology Unit, S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy , and.
authors.forename: Bruno
authors.initials: B
authors.lastname: Laganà
authors.affiliation: c Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Calafiore
authors.affiliation: c Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Guglielmelli
authors.affiliation: c Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Luisanna
authors.initials: L
authors.lastname: Basile
authors.affiliation: c Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Maria Giulia
authors.initials: MG
authors.lastname: Mutolo
authors.affiliation: c Ophthalmology Unit, NESMOS Department S. Andrea Hospital, Faculty of Medicine and Psychology , "Sapienza" University of Rome , Rome , Italy.
authors.forename: Santi Maria
authors.initials: SM
authors.lastname: Recupero
mesh_terms: D002387:Cataract Extraction; D016572:Cyclosporine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008727:Methotrexate / Q000627:therapeutic use; D010201:Panniculitis, Nodular Nonsuppurative / Q000175:diagnosis* / Q000188:drug therapy; D031300:Retinal Vasculitis / Q000175:diagnosis* / Q000188:drug therapy; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy; D014792:Visual Acuity; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D003907:Dexamethasone; D016572:Cyclosporine; D008727:Methotrexate
keywords: Corticosteroids; ocular inflammation; retinal vasculitis; uveitis; weber-christian disease