title: Bilayer matrix tablets for prolonged actions of metformin hydrochloride and repaglinide.
abstract: A combination therapy of metformin hydrochloride (MH) and repaglinide (RG) achieves a perfect glycemic control; however, the combination formulation of immediate release must be taken several times a day, compromising the therapeutic benefits and causing inconveniences to the patients. Herein, a bilayer matrix tablet that aimed at continuously releasing both MH and RG over time was developed, in which the two drugs were formulated into two separated layers. The tablets were prepared by wet granulation method, and the optimized formulation was obtained by evaluating the factors that affected the drug release. The bilayer tablets simultaneously released the two drugs over 12 h; and a better in vivo performance with a steady plasma concentration, markedly lower Cmax, prolonged Tmax, and perfect absorption was obtained. Summarily, the bilayer matrix tablets sustained both MH and RG release over time, thereby prolonging the actions for diabetic therapy and producing better health outcomes.
authors.affiliation: State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Shijing
authors.initials: S
authors.lastname: Huang
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhou
authors.forename: Lin
authors.initials: L
authors.lastname: Cao
authors.forename: Jing
authors.initials: J
authors.lastname: Yao
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhou
authors.forename: Guangji
authors.initials: G
authors.lastname: Wang
authors.forename: Lifang
authors.initials: L
authors.lastname: Yin
mesh_terms: D000818:Animals; D002219:Carbamates / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004285:Dogs; D004338:Drug Combinations; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000737:chemistry*; D010880:Piperidines / Q000008:administration & dosage / Q000737:chemistry*; D013607:Tablets / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D002219:Carbamates; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D010880:Piperidines; D013607:Tablets; C072379:repaglinide; D008687:Metformin