title: Group IIa secretory phospholipase A2 (sPLA2IIa) and progression in patients with lung cancer.
abstract: OBJECTIVE
  Group IIa secretory phospholipase A2 (sPLA2 IIa) plays a role in the malignant potential of several epithelial cancers. It is overexpressed in many cancer specimens and its elevated levels are correlated with high tumor grade and metastasis. Here, we evaluate the clinical significance of sPLA2 IIa in lung adenocarcinoma and the role of sPLA2 IIa in the process of cancer cell invasion and metastasis.
  
  
  METHODS
  Immunohistochemistry was used to investigate sPLA2 IIa in surgically resected lung adenocarcinoma of 180 patients and its correlation with survival. We overexpressed sPLA2 IIa in a lung adenocarcinoma cell line with very low sPLA2 IIa levels and investigated the in vitro and in vivo effects of sPLA2 IIa expression.
  
  
  RESULTS
  High expression of sPLA2 IIa in lung cancer tissue was significantly associated with clinical stage, metastasis, postoperative relapse and shorter patient survival. The overexpression of sPLA2 IIa enhanced xenograft tumor growth and invasion in vitro.
  
  
  CONCLUSIONS
  sPLA2 IIa expression can predict the clinical outcome of lung adenocarcinoma patients. sPLA2 IIa is a novel invasion-promoting gene in lung adenocarcinoma.
authors.affiliation: Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, China. wangmei2012729@126.com.
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: F-Y
authors.initials: FY
authors.lastname: Hao
authors.forename: J-G
authors.initials: JG
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Xiao
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology* / Q000601:surgery; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D045744:Cell Line, Tumor; D018450:Disease Progression; D054501:Group II Phospholipases A2 / Q000096:biosynthesis*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology* / Q000473:pathology* / Q000601:surgery; D051379:Mice; D016513:Mice, SCID; D009361:Neoplasm Invasiveness / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D014408:Biomarkers, Tumor; D054501:Group II Phospholipases A2; C516287:PLA2G2A protein, human