title: The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand.
abstract: The asymmetric alkylation of ketones represents a fundamental transformation in organic chemistry. Chiral auxiliaries have been used almost exclusively for this transformation. Herein we describe a strategy for the generation of enantiomerically enriched α-alkylated ketones up to an er of 83 : 17, using a chiral ligand protocol.
authors.affiliation: Analytical and Biological Chemistry Research Facility and Department of Chemistry, University College Cork, Cork, Ireland. g.mcglacken@ucc.ie.
authors.forename: Christina M
authors.initials: CM
authors.lastname: McSweeney
authors.forename: Vera M
authors.initials: VM
authors.lastname: Foley
authors.forename: Gerard P
authors.initials: GP
authors.lastname: McGlacken
mesh_terms: D000478:Alkylation; D006835:Hydrazones / Q000737:chemistry*; D008024:Ligands; D013034:Sparteine / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006835:Hydrazones; D008024:Ligands; D013034:Sparteine