title: Prophylactic effect of low dose vitamin D in osteopenia of prematurity: a clinical trial study.
abstract: Osteopenia of prematurity (OOP) is a preventable disease. Improved survival of premature newborns is associated with an increased incidence of OOP. The purpose of this study was to compare the prophylactic effects of two low doses of vitamin D (200 and 400 IU/Day) on the clinical, biochemical and radiological indices of the rickets of prematurity. In a randomized clinical trial, 60 preterm newborns with birth weight < 2000 g & gestational age < 37 weeks were randomly divided in two groups. Thirty newborns received 200 IU/d of vitamin D in group one and 30 ones received 400 IU/day of vitamin D in group two. On the 6th to 8th weeks of life, serum calcium, phosphate, alkaline phosphates, and 25-hydroxy vitamin D concentrations were measured and x- ray of left wrist and physical examination were performed. Both groups had no difference in biochemical, radiological or clinical presentation of rickets. Current study indicated that low dose vitamin D (200 IU/Day) is enough for prevention of OOP.
authors.affiliation: Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. p.alizadet@yahoo.com.
authors.forename: Paymaneh
authors.initials: P
authors.lastname: Alizadeh Taheri
authors.affiliation: Department of Pediatrics, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. nsajjadian@yahoo.com.
authors.forename: Negar
authors.initials: N
authors.lastname: Sajjadian
authors.affiliation: Department of Pediatrics, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. ybeyrami@yahoo.com.
authors.forename: Bahram
authors.initials: B
authors.lastname: Beyrami
authors.affiliation: Family Health Institute, Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran. mshariat@tums.ac.ir.
authors.forename: Mamak
authors.initials: M
authors.lastname: Shariat
mesh_terms: D001851:Bone Diseases, Metabolic / Q000517:prevention & control*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000517:prevention & control*; D019102:Infant, Very Low Birth Weight; D008297:Male; D010710:Phosphates / Q000097:blood; D012279:Rickets / Q000517:prevention & control*; D014807:Vitamin D / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D010710:Phosphates; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D