title: Oxalyl amide assisted palladium-catalyzed arylation of C(sp2)-H bond at the δ position.
abstract: A successful protocol has been developed for δ-arylation of β-arylethamines at the ortho position under mild conditions. The newly developed methodology first presents broad substrate scope, great functional group tolerance, and good to excellent yield in the synthesis of substituted β-arylethylamines. The transformation represents a practical advantage of oxalyl amide in assistance with C-H functionalization at a remote position.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Han
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Daqing
authors.initials: D
authors.lastname: Shi
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Huang
authors.forename: Yingsheng
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D005021:Ethylamines / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D005021:Ethylamines; D010165:Palladium