title: Poliovirus-induced changes in cellular membranes throughout infection.
abstract: The membrane landscape of a cell often changes drastically upon infection by a virus. In the case of the well-studied positive strand RNA virus poliovirus, the short infection cycle induces vesicles and tubular structures early in infection, and double-membraned vesicles late in infection. In this review, the current understanding of membrane changes in a PV-infected cell, the host and viral factors that facilitate these changes, and how these changes may promote virus replication will be discussed. Host factors involved in membrane rearrangement during infection include components of the COPI and COPII secretory pathways, lipid kinases, and the autophagy pathway. The roles of cellular membranes include acting as a scaffold for the RNA replication complex and roles in exit of mature virus. Finally, recent studies suggesting that not all picornaviruses are truly 'non-enveloped' are discussed in the context of the field, raising the possibility that cell-derived membranes play a role in delivering poliovirus particles to the extracellular space.
authors.affiliation: Department of Microbiology and Molecular Genetics, Center for Infectious Disease Research, Medical College of Wisconsin, Milwaukee, WI 53226, United States. Electronic address: wjackson@mcw.edu.
authors.forename: William T
authors.initials: WT
authors.lastname: Jackson
mesh_terms: D002462:Cell Membrane / Q000276:immunology / Q000821:virology*; D054884:Host-Pathogen Interactions; D007425:Intracellular Membranes / Q000276:immunology / Q000821:virology*; D017955:Poliovirus / Q000502:physiology*; D057074:Virus Release; D014779:Virus Replication