title: Use of left ventricular support devices during acute coronary syndrome and percutaneous coronary intervention.
abstract: In an effort to improve outcomes in percutaneous coronary intervention (PCI), percutaneous ventricular assist devices (PVADs) have been investigated in (1) high-risk PCI, (2) acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) and (3) in AMI without CS. PCI has become an increasing complex due to an ageing population with complex disease and the frequent presence of impaired LV function. Patients undergoing high-risk PCI in these circumstances are prone to acute cardiovascular collapse. Additionally, mortality in AMI complicated by CS remains high. Lastly, LV support during AMI may reduce infarct size and therefore preserve LV function. At present, four commercially available devices exist: intra-aortic balloon pump counterpulsation (IABP), Impella, TandemHeart and extracorporeal membrane oxygenation (ECMO). These devices are employed in an effort to increase cardiac output, mean arterial pressure (MAP) and coronary perfusion and to reduce pulmonary capillary wedge pressure (PCWP). The mechanism of action differs with each device, and there are advantages and disadvantages. In this update, we discuss recent data describing the use of PVADs to support patients with AMI with or without cardiogenic shock and during high-risk PCI. We focus on the unique features of each device, highlighting strengths, weaknesses and frequently encountered complications, which may be important when tailoring the most appropriate PVAD therapy to an individual patient's need.
authors.affiliation: Department of Cardiology, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK.
authors.forename: Jon
authors.initials: J
authors.lastname: Spiro
authors.forename: Sagar N
authors.initials: SN
authors.lastname: Doshi
mesh_terms: D054058:Acute Coronary Syndrome / Q000503:physiopathology / Q000628:therapy*; D003362:Cost-Benefit Analysis; D015199:Extracorporeal Membrane Oxygenation / Q000706:statistics & numerical data; D006353:Heart-Assist Devices / Q000706:statistics & numerical data*; D006801:Humans; D007423:Intra-Aortic Balloon Pumping / Q000706:statistics & numerical data; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D018579:Patient Selection; D062645:Percutaneous Coronary Intervention / Q000706:statistics & numerical data; D018570:Risk Assessment; D012307:Risk Factors; D012770:Shock, Cardiogenic / Q000503:physiopathology / Q000628:therapy*; D016896:Treatment Outcome