title: [Research on application of determination of MMP-13 in osteoarthritis].
abstract: Osteoarthritis (OA) is a complex chronic progressive disease attacked by biological and mechanical factors and a result from the anabolic and catabolic imbalance in chondrocyte, subchondral bone and extracellular matrix(ECM). Etiology and pathological of OA are not yet entirely clear. The degradation and destruction of collagen II caused by matrix metalloproteinase -13 (MMP-13) is considered the core factor in the occurrence and development of OA. The research of MMP-13 inhibitor provide ideas and methods for the treatment of OA. In this article,the role and determination of MMP-13 in OA and the development prospect of MMP-13 inhibitor in the treatment of OA research progress were reviewed.
authors.forename: Wen-Xiao
authors.initials: WX
authors.lastname: Chen
authors.forename: Fang-Jun
authors.initials: FJ
authors.lastname: Shan
authors.forename: Hong-Ting
authors.initials: HT
authors.lastname: Jin
authors.forename: Ping-Er
authors.initials: PE
authors.lastname: Wang
authors.forename: Lu-Wei
authors.initials: LW
authors.lastname: Xiao
authors.forename: Pei-Jian
authors.initials: PJ
authors.lastname: Tong
mesh_terms: D000818:Animals; D003094:Collagen / Q000378:metabolism; D006801:Humans; D053509:Matrix Metalloproteinase 13 / Q000032:analysis / Q000502:physiology*; D061965:Matrix Metalloproteinase Inhibitors / Q000627:therapeutic use; D010003:Osteoarthritis / Q000188:drug therapy / Q000209:etiology*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D003094:Collagen; D053509:Matrix Metalloproteinase 13