title: Development ofStreptococcus pneumoniaeVaccines Using Live Vectors.
abstract: Streptococcus pneumoniaestill causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular vaccines and capsular conjugate vaccines, such as serotype replacement, limited coverage and high costs. A recombinant live vector vaccine delivering protective antigens is a promising way to achieve this goal. In this review, we discuss the researches using live recombinant vaccines, mainly live attenuatedSalmonellaand lactic acid bacteria, to deliver pneumococcal antigens. We also discuss both the limitations and the future of these vaccines.
authors.affiliation: Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
authors.forename: Shifeng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA;
authors.forename: Roy
authors.initials: R
authors.lastname: Curtiss
keywords: BCG; Salmonella; Streptococcus pneumoniae; adenoviruses; bacterial vector; lactic acid bacteria; viral vector