title: Radical cascade cyanomethylation of activated alkenes to construct cyano substituted oxindoles.
abstract: The cyanomethyl radical was easily generated from acetonitrile by using DTBP, which was applied to a cascade alkene addition and cyclization reaction to construct useful oxindole derivatives. This protocol features simple manipulation, cheap reagents and a broad substrate scope. In addition, nitro substituted oxindoles were also synthesized for the first time.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P. R. China. gg2b@scu.edu.cn jsyou@scu.edu.cn.
authors.forename: Juan
authors.initials: J
authors.lastname: Li
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Wang
authors.forename: Ningjie
authors.initials: N
authors.lastname: Wu
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Jingsong
authors.initials: J
authors.lastname: You