title: RNA-binding proteins, multifaceted translational regulators in cancer.
abstract: RNA-binding proteins (RBPs) orchestrate transcript fate and function. Even though alterations in post-transcriptional events contribute to key steps of tumor initiation and progression, RBP-mediated control has remained relatively unexplored in cancer. Here, we discuss examples of this promising field focusing on translation regulation, and highlight the variety of molecular mechanisms by which RBPs impinge on translation with consequences for tumorigenesis. This article is part of a Special Issue entitled: Translation and Cancer.
authors.affiliation: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Laurence
authors.initials: L
authors.lastname: Wurth
authors.affiliation: Gene Regulation, Stem Cells and Cancer Programme, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain. Electronic address: fatima.gebauer@crg.eu.
authors.forename: Fátima
authors.initials: F
authors.lastname: Gebauer
mesh_terms: D000818:Animals; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D009363:Neoplasm Proteins; D016601:RNA-Binding Proteins
keywords: Cancer; Cytoplasmic polyadenylation; IRES; RNA-binding protein; Translation