title: Impact of time to treatment of oseltamivir on influenza hospitalization cost among Korean children.
abstract: BACKGROUND
  Although oseltamivir is a common influenza treatment, there is a lack of data on the economic benefits of timely oseltamivir treatment.
  
  
  METHODS
  From February 2004 through June 2007, 116 hospitalized children ≤ 15 years of age with laboratory-confirmed influenza who received oseltamivir were identified via retrospective medical chart review. Demographic, clinical, and cost data were abstracted and multivariate linear regression was used to assess the association between oseltamivir time to treatment and treatment-related costs among hospitalized children with laboratory-confirmed influenza.
  
  
  RESULTS
  Overall, 28% (n = 33) of patients were treated with oseltamivir ≥ day 3 of admission. Rapid influenza diagnostic test was used in a significantly lower proportion of patients treated with oseltamivir ≥ day 3 of admission compared with those who received oseltamivir earlier. On multivariate linear regression, initiation of oseltamivir ≥ day 3 of admission was associated with a 60.84% increase (95%CI: 32.59-95.11) in treatment-related hospital costs, compared with initiation on admission.
  
  
  CONCLUSIONS
  Delayed initiation of oseltamivir was found to be associated with increased treatment-related hospital costs among children hospitalized with laboratory-confirmed influenza.
authors.affiliation: International Vaccine Institute, Seoul, Korea.
authors.forename: Jacqueline K
authors.initials: JK
authors.lastname: Lim
authors.affiliation: Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, USA.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Kilgore
authors.affiliation: Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, Michigan, USA.
authors.forename: Allison E
authors.initials: AE
authors.lastname: Aiello
authors.affiliation: Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, Michigan, USA.
authors.forename: Betsy
authors.initials: B
authors.lastname: Foxman
authors.affiliation: International Vaccine Institute, Seoul, Korea.
authors.forename: G William
authors.initials: GW
authors.lastname: Letson
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Gi-Young
authors.initials: GY
authors.lastname: Jang
authors.affiliation: Department of Pediatrics, National Medical Center, Seoul, Korea.
authors.forename: Eunhee
authors.initials: E
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, Inje College of Medicine, Seoul, Korea.
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Song
authors.affiliation: Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Yun-Kyung
authors.initials: YK
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D017721:Hospital Costs / Q000639:trends*; D006760:Hospitalization / Q000191:economics*; D006801:Humans; D015994:Incidence; D007251:Influenza, Human / Q000188:drug therapy* / Q000191:economics / Q000453:epidemiology; D008297:Male; D053139:Oseltamivir / Q000627:therapeutic use*; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D013997:Time Factors; D061665:Time-to-Treatment
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir
keywords: children; hospital cost; influenza; oseltamivir; rapid influenza diagnostic test