title: Comparative Analysis of Various Aspects of Plateletpheresis on the Fenwal Amicus and Fresenius COM.TEC Cell Separator Instruments.
abstract: OBJECTIVE
  To compare the Fenwal Amicus and the Fresenius COM.TEC apheresis instruments regarding donor peripheral blood parameters, operational variables of the instruments, and quality control parameters of the product obtained.
  
  
  METHODS
  We performed 100 platelet collections from 100 voluntary donors using the 2 studied devices. We measured platelet count using an automated analyzer and analyzed the activation statuses using a flow cytometer.
  
  
  RESULTS
  The median time needed to perform the procedures was significantly longer with the COM.TEC. However, the product we obtained using the Amicus instrument showed higher degrees of platelet-activation. All products we obtained with both instruments had white blood cell counts of less than 5 × 10(6) per bag. We observed no statistical difference regarding collection efficiency and collection rates between the devices.
  
  
  CONCLUSIONS
  Both instruments collected platelets efficiently, with minimal donor discomfort. Compared with the COM.TEC instrument, the Amicus reached the platelet target yield more quickly; however, it displayed an increase in platelet activation.
authors.affiliation: Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India.
authors.forename: Joseph
authors.initials: J
authors.lastname: Philip
authors.affiliation: Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India amit.bsy83@gmail.com.
authors.forename: Amit Kumar
authors.initials: AK
authors.lastname: Biswas
authors.affiliation: Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India.
authors.forename: Tathagata
authors.initials: T
authors.lastname: Chatterjee
authors.affiliation: Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India.
authors.forename: Rajiv Singh
authors.initials: RS
authors.lastname: Mallhi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001782:Blood Donors; D002469:Cell Separation / Q000295:instrumentation*; D015331:Cohort Studies; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation; D010983:Plateletpheresis; D055815:Young Adult
keywords: cell separator; collection efficiency; collection rate; platelet activation; platelet yield; plateletpheresis