title: [Changing times - changing diseases. Review of the neuropathological autopsy documentations at the Markusovszky University Teaching Hospital (1964-2014)].
abstract: BACKGROUND
  Nearly 6000 autoptic studies were carried out during the last 50 years at the Laboratory of Neuropathology, Markusovszky University Teaching Hospital, Hungary.
  
  
  OBJECTIVE
  The aim of the authors was to present those previously frequent and often fatal conditions that can be prevented or treated today.
  
  
  METHODS
  Retrospective analyses of the neuropathological documentations.
  
  
  RESULTS
  Measles-related subacute sclerosing panencephalitis caused death in 13 cases, the last occurred in 1991. The mandatory vaccination against the causative virus has eliminated this severe neurological complication. Fourteen lives were lost due to herpes simplex encephalitis, including the last case seen in 1999. Feasibility of early diagnosis and the availability of acyclovir therapy resulted in better outcome without fatality. Tuberculous meningitis still occurred in most recent years, although only sporadically. Recognition of this condition is not straightforward due to its rarity, and considerations for this disease are often omitted from the routine differential diagnosis. The generally low mortality rates in tick borne encephalitis further dropped after the introduction of vaccination. Altogether only 8 such cases were documented. The last fatal cases of neurolues were seen in the 1990s. However, syphilis itself has not disappeared, and the number of cases with newly acquired infection continues to rise. The introduction of intrathecal methotrexate and radiotherapy made possible the prevention or effective treatment of meningeal leukosis. A careful coordination of these treatment modalities, however, is important as nervous system complications may develop in the form of disseminated necrotizing leukoencephalopathy that is also reflected in the records.
  
  
  CONCLUSIONS
  The 50-year neuropathology documentation reflects changes in the occurrence of diseases, and it calls attention to those disorders which can be prevented or treated today, but may represent diagnostic challenges.
authors.affiliation: Markusovszky Egyetemi Oktatókórház Patológiai Osztály Szombathely Markusovszky u. 5. 9700.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Garzuly
authors.affiliation: Markusovszky Egyetemi Oktatókórház Infektológiai Osztály Szombathely.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Schneider
authors.affiliation: Markusovszky Egyetemi Oktatókórház Haematológiai és Haemosztazeológiai Osztály Szombathely.
authors.forename: János László
authors.initials: JL
authors.lastname: Iványi
authors.affiliation: Markusovszky Egyetemi Oktatókórház Neurológiai Osztály Szombathely.
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Nagy
authors.affiliation: Markusovszky Egyetemi Oktatókórház Bőrgyógyászati Osztály Szombathely.
authors.forename: Mariann
authors.initials: M
authors.lastname: Varga
authors.affiliation: Markusovszky Egyetemi Oktatókórház Központi Aneszteziológiai és Intenzív Betegellátó Osztály Szombathely.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Sütő
authors.affiliation: Markusovszky Egyetemi Oktatókórház Patológiai Osztály Szombathely Markusovszky u. 5. 9700.
authors.forename: Balázs
authors.initials: B
authors.lastname: Tolvaj
authors.affiliation: Markusovszky Egyetemi Oktatókórház Kutatási és Oktatási Centrum Szombathely Pécsi Tudomány Egyetem Egészségtudományi Kar Pécs.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Kálmán
mesh_terms: D001344:Autopsy; D006785:Hospitals, University; D006801:Humans; D006814:Hungary; D008499:Medical Records; D009422:Nervous System Diseases / Q000473:pathology*; D012189:Retrospective Studies
keywords: changing occurrence of diseases; idegrendszeri fertőzések; leukaemiás szövődmények; nervous system complications of leukemia; neuroinfections; neuropathology; neuropatológia; változó előfordulás