title: Leptin of dermal adipose tissue is differentially expressed during the hair cycle and contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair.
abstract: Adipose tissue encircles the lower portion of anagen hair follicles and may regulate hair cycle progression. As leptin is a major adipokine, its level of expression from the dermal white adipose tissue during hair cycle progression was studied. The result shows that leptin level is differentially expressed during hair cycle, the lowest in early anagen phase, upregulated in late anagen phase and the highest in the telogen phase. On the other hand, leptin receptor is detected in keratin 15-positive hair bulge epithelium of both anagen- and telogen-phase hair follicles of mice pelage and vibrissa hair, and hair from human scalp. Leptin contributes to adipocyte-mediated growth inhibition of anagen-phase vibrissa hair as demonstrated in organ culture and coculture system. Our data suggest that leptin of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium.
authors.affiliation: Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; International Research Center of Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Chao-Chun
authors.initials: CC
authors.lastname: Yang
authors.forename: Hamm-Ming
authors.initials: HM
authors.lastname: Sheu
authors.forename: Pei-Lun
authors.initials: PL
authors.lastname: Chung
authors.forename: Chung-Hsing
authors.initials: CH
authors.lastname: Chang
authors.forename: Yau-Sheng
authors.initials: YS
authors.lastname: Tsai
authors.forename: Michael W
authors.initials: MW
authors.lastname: Hughes
authors.forename: Tai-Lan
authors.initials: TL
authors.lastname: Tuan
authors.forename: Lynn L H
authors.initials: LL
authors.lastname: Huang
mesh_terms: D017667:Adipocytes / Q000166:cytology; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D018920:Coculture Techniques; D020405:Dermis / Q000378:metabolism; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006197:Hair / Q000502:physiology*; D006801:Humans; D020738:Leptin / Q000502:physiology*; D051379:Mice; D009924:Organ Culture Techniques; D012867:Skin / Q000378:metabolism*
chemical_list: D020738:Leptin
keywords: adipocytes; adipokines; hair follicles; leptin