title: Recent advancement in understanding colitis-associated tumorigenesis.
abstract: Chronic inflammation predisposes patients with inflammatory bowel disease to the risk of developing colitis-associated cancer (CAC). Growing evidence strongly suggests that CAC development is multifactorial and is attributed to concurrent, dynamic dysregulations in host immunity, enteric microbiota, and epithelial restitution during the course of chronic inflammation. This article discusses the recent advances in understanding the different forms of CAC that may develop in patients with inflammatory bowel disease and animal models, as well as molecular alterations and other processes that orchestrate the development of CAC.
authors.affiliation: *Gastrointestinal Unit, Department of Medicine, †Department of Pathology, and ‡Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
authors.forename: Daren
authors.initials: D
authors.lastname: Low
authors.forename: Mari
authors.initials: M
authors.lastname: Mino-Kenudson
authors.forename: Emiko
authors.initials: E
authors.lastname: Mizoguchi
mesh_terms: D000818:Animals; D003092:Colitis / Q000150:complications* / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology* / Q000473:pathology*; D006801:Humans