title: A comparison of single-dose dexmedetomidine or propofol on the incidence of emergence delirium in children undergoing general anaesthesia for magnetic resonance imaging.
abstract: Emergence delirium is a significant problem in children regaining consciousness following general anaesthesia. We compared the emergence characteristics of 120 patients randomly assigned to receive a single intravenous dose of dexmedetomidine 0.3 μg.kg(-1) , propofol 1 mg.kg(-1) , or 10 ml saline 0.9% before emerging from general anaesthesia following a magnetic resonance imaging scan. Emergence delirium was diagnosed as a score of 10 or more on the Paediatric Anaesthesia Emergence Delirium scale. The incidence of emergence delirium was 42.5% in the dexmedetomidine group, 33.3% in the propofol group and 41.5% in the saline group (p = 0.671). Three patients in the dexmedetomidine group, none in the propofol group and two in the saline group required pharmacological intervention for emergence delirium (p = 0.202). Administration of neither dexmedetomidine nor propofol significantly reduced the incidence, or severity, of emergence delirium. The only significant predictor for emergence delirium was the time taken to awaken from general anaesthesia, with every minute increase in wake-up time reducing the odds of emergence delirium by 7%.
authors.affiliation: Department of Paediatric Anaesthesia, KK Women's and Children's Hospital, Singapore.
authors.forename: C L
authors.initials: CL
authors.lastname: Bong
authors.forename: E
authors.initials: E
authors.lastname: Lim
authors.forename: J C
authors.initials: JC
authors.lastname: Allen
authors.forename: W L H
authors.initials: WL
authors.lastname: Choo
authors.forename: Y N
authors.initials: YN
authors.lastname: Siow
authors.forename: P B Y
authors.initials: PB
authors.lastname: Teo
authors.forename: J S K
authors.initials: JS
authors.lastname: Tan
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003693:Delirium / Q000139:chemically induced / Q000517:prevention & control*; D020927:Dexmedetomidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000627:therapeutic use; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol