title: Association between miR34b/c polymorphism rs4938723 and cancer risk: a meta-analysis of 11 studies including 6169 cases and 6337 controls.
abstract: BACKGROUND
  The functional polymorphism rs4938723 in the promoter region of pri-miR-34b/c is potentially associated with susceptibility to several cancers, including hepatocellular carcinoma, colorectal cancer, and breast cancer. Here we conducted a comprehensive meta-analysis to investigate the association between rs4938723 and cancer risk.
  
  
  METHODS
  Eligible studies extracted from the databases of PubMed, Web of Science, and Cochrane Library were evaluated. Statistical analysis was performed using Revman 5.2 and STATA 12.0 software.
  
  
  RESULTS
  By characterizing the extracted data, a total of 11 studies reported in 10 publications including 6169 cases and 6337 controls were selected for further analysis. Our results revealed a significant association between the rs4938723 polymorphism and cancer risk in the codominant model (TC vs. TT: OR=1.10, 95% CI=1.02-1.19, P=0.009) but not in other genetic models. In the stratified analysis of different cancer types, a significant association was found in nasopharyngeal cancer, osteosarcoma, and renal cell cancer. Furthermore, stratified analysis of ethnicity indicated that a highly significant association was shown in the Asian population in a codominant model (TC vs. TT: OR=1.13, 95% CI=1.03-1.24, P=0.007) when compared with African-Americans and Caucasians.
  
  
  CONCLUSIONS
  Overall, the current study suggests that the miR-34b/c rs4938723 polymorphism may be associated with the risk of cancers, including nasopharyngeal cancer, osteosarcoma, and renal cell cancer, and to some extent this polymorphism is closely related to cancer susceptibility in Asians.
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Xinjing
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Xiongxiong
authors.initials: X
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Yuan
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Xiaxing
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Chenghong
authors.initials: C
authors.lastname: Peng
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Hongwei
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiaotong University School of Medicine, Shanghai Institute of Digestive Surgery, Shanghai, China (mainland).
authors.forename: Baiyong
authors.initials: B
authors.lastname: Shen
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C522425:MIRN34 microRNA, human; D035683:MicroRNAs