title: Fluorescent sensors based on quinoline-containing styrylcyanine: determination of ferric ions, hydrogen peroxide, and glucose, pH-sensitive properties and bioimaging.
abstract: A novel styrylcyanine-based fluorescent probe 1 was designed and synthesized via facile methods. Ferric ions quenched the fluorescence of probe 1, whereas the addition of ferrous ions led to only small changes in the fluorescence signal. When hydrogen peroxide was introduced into the solution containing probe 1 and Fe(2+) , Fe(2+) was oxidized to Fe(3+), resulting in the quenching of the fluorescence. The probe 1/Fe(2+) solution fluorescence could also be quenched by H2 O2 released from glucose oxidation by glucose oxidase (GOD), which means that probe 1/Fe(2+) platform could be used to detect glucose. Probe 1 is fluorescent in basic and neutral media but almost non-fluorescent in strong acidic environments. Such behaviour enables it to work as a fluorescent pH sensor in both the solution and solid states and as a chemosensor for detecting volatile organic compounds with high acidity and basicity. Subsequently, the fluorescence microscopic images of probe 1 in live cells and in zebrafish were achieved successfully, suggesting that the probe has good cell membrane permeability and a potential application for imaging in living cells and living organisms.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Yang
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P.R. China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Zhao
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P.R. China.
authors.forename: Jinqing
authors.initials: J
authors.lastname: Qu
authors.affiliation: School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, P.R. China.
authors.forename: Ruiyuan
authors.initials: R
authors.lastname: Liu
mesh_terms: D000818:Animals; D004625:Embryo, Nonmammalian / Q000000981:diagnostic imaging; D005290:Ferric Compounds / Q000032:analysis*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005947:Glucose / Q000032:analysis*; D005949:Glucose Oxidase / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D008856:Microscopy, Fluorescence; D010084:Oxidation-Reduction; D011804:Quinolines / Q000737:chemistry; D015027:Zebrafish / Q000196:embryology
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; D011804:Quinolines; D006861:Hydrogen Peroxide; C037219:quinoline; D005949:Glucose Oxidase; D005947:Glucose
keywords: bioimaging; ferric ions; fluorescent sensor; hydrogen peroxide; pH sensitive; quinoline