title: Clinical aspects of sepsis: an overview.
abstract: Sepsis is one of the oldest and most elusive syndromes in medicine. With the confirmation of germ theory by Semmelweis, Pasteur, and others, sepsis was considered as a systemic infection by a pathogenic organism. Although the germ is probably the beginning of the syndrome and one of the major enemies to be identified and fought, sepsis is something wider and more elusive. In this chapter clinically relevant themes of sepsis will be approached to provide an insight of everyday clinical practice for healthcare workers often not directly involved in the patient's management.
authors.affiliation: Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Monti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Landoni
authors.forename: Daiana
authors.initials: D
authors.lastname: Taddeo
authors.forename: Francesca
authors.initials: F
authors.lastname: Isella
authors.forename: Alberto
authors.initials: A
authors.lastname: Zangrillo
mesh_terms: D000005:Abdomen / Q000382:microbiology / Q000473:pathology; D058186:Acute Kidney Injury / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification / Q000472:pathogenicity; D019468:Disease Management; D005440:Fluid Therapy; D006801:Humans; D007022:Hypotension / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D000860:Hypoxia / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D008168:Lung / Q000382:microbiology / Q000473:pathology; D017410:Practice Guidelines as Topic; D012772:Shock, Septic / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D013921:Thrombocytopenia / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D014551:Urinary Tract / Q000187:drug effects / Q000382:microbiology / Q000473:pathology
chemical_list: D000900:Anti-Bacterial Agents