title: [Double-component bacterial regulation systems as a target for searching new antimicrobial agents].
abstract: A review of the literature data concerning double-component bacterial regulation systems was given. The observed data concern: a) structural and functional organization based on the example of systems of the family OmpR (EnvZ/OmpR, PhoQ/PhoP), which regulate a number of processes providing adaptation to stress conditions in the environment and host body providing the virulence and biofilm formation, the cause of different human chronic infections; b) the genes and functions regulated by the double-components systems, based on the example of EnvZ/OmpR system, especially OmpR protein, and PhoQ/PhoP system. The possibilities for the searching of the double-component system protein inhibitors and their role in depressing pathogenic bacteria virulence were discussed.
authors.forename: I G
authors.initials: IG
authors.lastname: Tiganova
authors.forename: T S
authors.initials: TS
authors.lastname: Il'ina
authors.forename: Yu M
authors.initials: YM
authors.lastname: Romanova
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms; D015964:Gene Expression Regulation, Bacterial; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014774:Virulence / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C112177:osmolarity response regulator proteins