title: Soluble ligand CD40 and uric acid as markers of atheromatosis in patients with obstructive sleep apnea.
abstract: The aim of the study was to evaluate the risk of atheromatosis in patients with obstructive sleep apnea (OSA), as based on the concentration of the pro-atherogenic soluble CD40L ligand (sCD40L) in relation to the level of uric acid. The serum levels of sCD40L and uric acid were measured in 79 OSA patients (mean apnea/hypopnea index - AHI 34.4 ± 20.9) and in 40 healthy controls. We found that sCD40L was higher in the OSA patients with hyperuricemia than that in the patients with uric acid in the normal range (sCD40L: 9.0 ng/ml vs. 8.0 ng/ml, respectively, p < 0.05). There was a positive association of sCD40L with AHI (p = 0.01) and a negative one with the mean minimal nocturnal SaO₂(p < 0.05). Uric acid correlated negatively with the mean and minimal SaO₂and positively with the oxygen desaturation index (p < 0.05). OSA patients with hyperuricemia also had a higher prevalence of hypertension and ischemic heart disease. We conclude that OSA patients with increased uric acid concentration have increased risk of atheromatosis, as indicated by a higher level of soluble pro-atherogenic ligand CD40, and a higher prevalence of cardiovascular adverse events.
authors.affiliation: Department of Pulmonology and Lung Cancer, Wroclaw Medical University, 105 Grabiszynska St., Wroclaw, 53-439, Poland, mokka113@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Kosacka
authors.forename: A
authors.initials: A
authors.lastname: Brzecka
authors.forename: P
authors.initials: P
authors.lastname: Piesiak
authors.forename: A
authors.initials: A
authors.lastname: Korzeniewska
authors.forename: R
authors.initials: R
authors.lastname: Jankowska
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D023201:CD40 Ligand / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D033461:Hyperuricemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000175:diagnosis; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D023201:CD40 Ligand; D014527:Uric Acid