title: [Inhaled nitric oxide for children with acute respiratory distress syndrome].
abstract: OBJECTIVE
  The objective of this study was to review the literature on inhaled nitric oxide to children with acute respiratory distress syndrome.
  
  
  BACKGROUND
  A review of literature and selection of the most important publications on inhaled nitric oxide, using the MedLine and Cochrane Systematic Review Databases. This review was organized as follows: introduction; metabolism and biological effects; clinical applications; dosage, gas administration and weaning process; warnings and side-effects. Inhaled nitric oxide use was described in acute respiratory distress syndrome.
  
  
  CONCLUSIONS
  Inhaled nitric oxide as the first vasodilator to produce selective pulmonary vasodilation has beneficial effects on gas exchange and ventilation, improving outcome in children with severe hypoxia. It is safe when administered in intensive care units under strict surveillance and monitoring. Further studies should be concentrated on early treatment, when acute respiratory distress syndrome is potentially reversible.
authors.affiliation: Departamento de Pediatria, Unidade de Terapia Intensiva Pediátrica, FMB, UNESP.
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Fioretto
authors.affiliation: Departamento de Pediatria, Unidade de Terapia Intensiva Pediátrica, FMB, UNESP.
authors.forename: Mário Ferreira
authors.initials: MF
authors.lastname: Carpi
authors.affiliation: Departamento de Pediatria, Unidade de Terapia Intensiva Pediátrica, FMB, UNESP.
authors.forename: Rossano César
authors.initials: RC
authors.lastname: Bonatto
authors.affiliation: Unidade de Terapia Intensiva Pediátrica, UNESP.
authors.forename: Sandra Mara Queiroz
authors.initials: SM
authors.lastname: Ricchetti
authors.affiliation: Unidade de Terapia Intensiva Pediátrica, UNESP.
authors.forename: Marcos Aurélio de
authors.initials: MA
authors.lastname: Moraes