title: Erlotinib-induced skin inflammation is IL-1 mediated in KC-Tie2 mice and human skin organ culture.
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address: jelder@umich.edu.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Ward
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Narasimharao
authors.initials: N
authors.lastname: Bhagathavula
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Johnston
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Dawes
authors.affiliation: Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.
authors.forename: Wen
authors.initials: W
authors.lastname: Fu
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Sylviane
authors.initials: S
authors.lastname: Lambert
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Michael K
authors.initials: MK
authors.lastname: Dame
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Roscoe L
authors.initials: RL
authors.lastname: Warner
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: Johann E
authors.initials: JE
authors.lastname: Gudjonsson
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
authors.forename: James
authors.initials: J
authors.lastname: Varani
authors.affiliation: Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA. Electronic address: nicole.ward@case.edu.
authors.forename: James T
authors.initials: JT
authors.lastname: Elder
mesh_terms: D000818:Animals; D001706:Biopsy; D003872:Dermatitis / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000069347:Erlotinib Hydrochloride; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D009924:Organ Culture Techniques; D010641:Phenotype; D011799:Quinazolines / Q000009:adverse effects* / Q000494:pharmacology; D042787:Receptor, TIE-2 / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D007375:Interleukin-1; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride; D042787:Receptor, TIE-2; C079086:Tek protein, mouse