title: Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.
abstract: pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Joe E
authors.initials: JE
authors.lastname: Baio
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Denise
authors.initials: D
authors.lastname: Schach
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Adrian V
authors.initials: AV
authors.lastname: Fuchs
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Schmüser
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Nils
authors.initials: N
authors.lastname: Billecke
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Bubeck
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Mischa
authors.initials: M
authors.lastname: Bonn
authors.affiliation: Karlsruhe Institute of Technology, Institute for Applied Materials and Karlsruhe Nano Micro Facility, 76344 Eggenstein-Leopoldshafen, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bruns
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.|University of Applies Sciences Bingen, 55411 Bingen, Germany.
authors.forename: Clemens K
authors.initials: CK
authors.lastname: Weiss
authors.affiliation: Max Planck Institute for Polymer Research, 55270 Mainz, Germany.
authors.forename: Tobias
authors.initials: T
authors.lastname: Weidner
mesh_terms: D000595:Amino Acid Sequence; D057846:Cell-Penetrating Peptides / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D055767:Immobilized Proteins / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013499:Surface Properties
chemical_list: D057846:Cell-Penetrating Peptides; D055767:Immobilized Proteins; D010455:Peptides; C066951:GALA peptide; D006046:Gold