title: Recent results in the search for new molecules with ambergris odor.
abstract: The synthesis of new odorant molecules is still a challenging task for the fragrance chemist, because now as ever it is difficult to predict the odor properties of small organic molecules. Therefore, certain tools, such as, e.g., lead-structure optimization of existing odorants, are helpful techniques. In this article, we describe the synthesis and the odor properties of a new molecule derived by the so-called 'seco' lead-structure optimization of the ambergris compound Ambroxide(®) . Based on these results, more representatives with similar structures have been synthesized and evaluated for their olfactory properties.
authors.affiliation: Symrise AG, Scent & Care Innovations, Mühlenfeldstrasse 1, D-37603 Holzminden. johannes.panten@symrise.com.
authors.forename: Johannes
authors.initials: J
authors.lastname: Panten
authors.forename: Horst
authors.initials: H
authors.lastname: Surburg
authors.forename: Bernd
authors.initials: B
authors.lastname: Hölscher
mesh_terms: D018648:Ambergris / Q000737:chemistry*; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009812:Odorants / Q000032:analysis*; D010476:Perfume / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D018648:Ambergris; D006575:Heterocyclic Compounds, 3-Ring; D010476:Perfume
keywords: Ambergris; Ambroxide; Structureodor relationship; ‘Seco-Ambroxide’