title: Burning pain secondary to clozapine use: a case report.
abstract: BACKGROUND
  The first of the atypical antipsychotics introduced in the 1970s, clozapine remains the most efficacious neuroleptic to this day. However, serious and potentially fatal side effects have necessitated careful regular monitoring among prescribing clinicians. Some adverse effects (e.g. ischaemic bowel) remain under recognized, while newly identified adverse effects continue to be described in the literature.
  
  
  METHODS
  In this report, we describe a healthy 43-year old Caucasian male who experienced onset of a full body deep burning pain several months after the onset of treatment with clozapine. The pain worsened over time, ceased with cessation of treatment, and returned soon after the patient was rechallenged.
  
  
  CONCLUSIONS
  We describe an unusual adverse effect from clozapine treatment that has not been described elsewhere to our knowledge. We present the time course of the pain symptom, relationship to dose, associated laboratory results, and ultimately how it was dealt with and how it improved for the benefit of clinicians who may encounter it in the future.
authors.forename: Bradley
authors.initials: B
authors.lastname: Linton
authors.forename: Rachel
authors.initials: R
authors.lastname: Fu
authors.forename: Penny A
authors.initials: PA
authors.lastname: MacDonald
authors.affiliation: Department of Psychiatry, University of Western Ontario, 800 Commissioners Road East, Zone B, Room B8-114, London, N6A 5W9, ON, Canada. hooman.ganjavi@lhsc.on.ca.
authors.forename: Hooman
authors.initials: H
authors.lastname: Ganjavi
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008297:Male; D010146:Pain / Q000139:chemically induced*; D011618:Psychotic Disorders / Q000188:drug therapy
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine