title: [Preparation and investigation of MRI-traceable Eudragit-E liquid embolic agent].
abstract: OBJECTIVE
  To develop and investigate the properties of MRI-traceable Eudragit-E liquid embolic agent (MR-E).
  
  
  METHODS
  Polyethylene glycol-modified superparamagnetic iron oxides (PEG-SPIO) was synthesized by chemical co-precipitation method. MR-E was prepared by mixing PEG-SPIO and Eudragit-E liquid embolic agent homogeneously. An in vitro MR phantom study was carried out to measure MR traceability of MR-E and to determine the concentration of PEG-SPIO for further studies. The microcatheter deliverability and sol-gel transition process of MR-E were investigated. MR-E was injected into the kidney of a Japanese white big ear rabbit via an angiographic microcatheter, and detected by MRI.
  
  
  RESULTS
  A PEG-SPIO concentration of 2 g/L was considered to be suitable for further studies. MR-E was injected through the microcatheter without any difficulty. MR-E instantly solidified on release into saline. Then 0.2 mL of MR-E effectively embolized distal renal arteries, and MR-E could be detected by MRI in the embolized kidney.
  
  
  CONCLUSIONS
  MR-E seems to be a promising MRI-traceable liquid embolic agent.
authors.affiliation: Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
authors.forename: Ying-ying
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
authors.forename: Xaio-jing
authors.initials: XJ
authors.lastname: Lu
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Zhuo-zhao
authors.initials: ZZ
authors.lastname: Zheng
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Guan
authors.affiliation: Department of Radiology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Nai-qi
authors.initials: NQ
authors.lastname: Fu
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Tian-shi
authors.initials: TS
authors.lastname: Lv
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Shui-sheng
authors.initials: SS
authors.lastname: Zhang
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Li
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Interventional Radiology and Vascular Surgery, Peking University First Hospital, Beijing 100034, China.
authors.forename: Ying-hua
authors.initials: YH
authors.lastname: Zou
authors.affiliation: Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
authors.forename: Tian-yuan
authors.initials: TY
authors.lastname: Fan
mesh_terms: D000818:Animals; D003911:Dextrans / Q000494:pharmacology*; D004621:Embolization, Therapeutic; D007668:Kidney / Q000187:drug effects; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D008768:Methylmethacrylates / Q000494:pharmacology*; D019047:Phantoms, Imaging; D011817:Rabbits; D012077:Renal Artery
chemical_list: D003911:Dextrans; D058185:Magnetite Nanoparticles; D008768:Methylmethacrylates; C102808:Eudragit-E; C065507:ferumoxides