title: Biased estimates of diminishing-returns epistasis? Empirical evidence revisited.
abstract: Empirical evidence for diminishing fitness returns of beneficial mutations supports Fisher's geometric model. We show that a similar pattern emerges through the phenomenon of regression to the mean and that few studies correct for it. Although biases are often small, regression to the mean has overemphasized diminishing returns and will hamper cross-study comparisons unless corrected for.
authors.affiliation: Animal Ecology at Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, SE-75236 Uppsala, Sweden david.berger@ebc.uu.se.
authors.forename: David
authors.initials: D
authors.lastname: Berger
authors.affiliation: Institute of Evolutionary Biology and Environmental Studies, University of Zurich, CH-8057 Zürich, Switzerland.
authors.forename: Erik
authors.initials: E
authors.lastname: Postma
mesh_terms: D000465:Algorithms; D004843:Epistasis, Genetic; D056084:Genetic Fitness; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D015203:Reproducibility of Results
keywords: Fisher’s geometric model; adaptation; epistasis; fitness landscape; regression to the mean