title: N,N'-dioxide-scandium(III)-catalyzed asymmetric Aza-Friedel-Crafts reaction of sesamol with aldimines.
abstract: A highly efficient aza-Friedel-Crafts reaction of sesamol with aldimines has been realized by using a chiral N,N'-dioxide-scandium(III) complex as the catalyst. A series of corresponding bioactive chiral α-amino-sesamols were obtained in moderate to good yields (up to 97%) with excellent enantioselectivities (up to 97% ee). Furthermore, the control experiments were conducted to provide fundamental insights into the mechanism of the reaction.
authors.affiliation: Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu 610064, P. R. China.
authors.forename: Sha
authors.initials: S
authors.lastname: Bai
authors.forename: Yuting
authors.initials: Y
authors.lastname: Liao
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Weiwei
authors.initials: W
authors.lastname: Luo
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Feng
mesh_terms: D001372:Aza Compounds / Q000737:chemistry; D052117:Benzodioxoles / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*
chemical_list: D001372:Aza Compounds; D052117:Benzodioxoles; D056831:Coordination Complexes; D007097:Imines; D010636:Phenols; C025583:sesamol; D012538:Scandium