title: Posterior reversible encephalopathy syndrome in a B-cell acute lymphoblastic leukemia young adult patient treated with a pediatric-like chemotherapeutic schedule.
abstract: We report here the case of a young adult affected by pre B-cell acute lymphoblastic leukemia (ALL), who developed, during a pediatric-like chemotherapy consolidation schedule with high dosage of Methotrexate, a severe neurological toxicity. Clinical presentation and neuroimaging data were diagnostic for posterior reversible encephalopathy syndrome (PRES). A complete resolution was quickly obtained with medical blood pressure control and anticonvulsants administration. To the best of our knowledge, this is the first case of PRES described in the adult ALL setting. Currently, the clinical management of this aggressive disease is moving towards a pediatric-like approach also in adult patients, due to the better outcome reached with intensive chemotherapeutic regimens in children population. However, therapy-related toxicities have to be taken into account, since their onset may adversely affect patients' clinical outcome.
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Volpato
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Abbenante
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Sartor
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine, Bologna University , Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
keywords: acute lymphoblastic leukemia; brain magnetic resonance imaging; methotrexate; posterior reversible encephalopathy syndrome; seizure