title: Nanomedicine strategies for targeting skin inflammation.
abstract: Topical treatment of skin diseases is an attractive strategy as it receives high acceptance from patients, resulting in higher compliance and therapeutic outcomes. Recently, the use of variable nanocarriers for dermal application has been widely explored, as they offer several advantages compared with conventional topical preparations, including higher skin penetration, controlled and targeted drug delivery and the achievement of higher therapeutic effects. This article will focus on skin inflammation or dermatitis as it is one of the most common skin problems, describing the different types and causes of dermatitis, as well as the typical treatment regimens. The potential use of nanocarriers for targeting skin inflammation and the achievement of higher therapeutic effects using nanotechnology will be explored.
authors.affiliation: Laboratory of Pharmaceutical Engineering & Biopharmaceutics, EA4267, University of Franche-Comté, Besançon, France.
authors.forename: Mona Ma
authors.initials: MM
authors.lastname: Abdel-Mottaleb
authors.forename: Celine
authors.initials: C
authors.lastname: Try
authors.forename: Yann
authors.initials: Y
authors.lastname: Pellequer
authors.forename: Alf
authors.initials: A
authors.lastname: Lamprecht
mesh_terms: D000287:Administration, Topical; D000818:Animals; D003872:Dermatitis / Q000628:therapy*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004655:Emulsions; D006801:Humans; D007249:Inflammation / Q000473:pathology* / Q000628:therapy*; D008055:Lipids / Q000737:chemistry; D051379:Mice; D008822:Mice, Transgenic; D018613:Microscopy, Confocal; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D012867:Skin / Q000473:pathology*; D012869:Skin Absorption; D012871:Skin Diseases / Q000628:therapy*
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D011108:Polymers
keywords: animal models; dermatitis; glucocorticoids; hair follicles; nanoparticles; skin inflammation; skin penetration; targeting