title: Characterisation of chicken viperin.
abstract: The identification of immune pathways that protect against pathogens may lead to novel molecular therapies for both livestock and human health. Interferon (IFN) is a major response pathway that stimulates multiple genes targeted towards reducing virus. Viperin is one such interferon stimulated gene (ISG) that helps protect mammals from virus and may be critical to protecting chickens in the same way. In chickens, ISGs are not generally well characterised and viperin, in concert with other ISGs, may be important in protecting against virus. Here we identify chicken viperin (ch-viperin) and show that ch-viperin is upregulated in response to viral signature molecules. We further show that viperin is upregulated in response to virus infection in vivo. This data will benefit investigators targeting the antiviral pathways in the chicken.
authors.affiliation: CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia; School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia.
authors.forename: Kate E
authors.initials: KE
authors.lastname: Goossens
authors.affiliation: CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia. Electronic address: adam.karpala@csiro.au.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Karpala
authors.affiliation: CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia.
authors.forename: Andreas
authors.initials: A
authors.lastname: Rohringer
authors.affiliation: School of Medicine, Deakin University, Waurn Ponds, Victoria, Australia.
authors.forename: Alistair
authors.initials: A
authors.lastname: Ward
authors.affiliation: CSIRO Australian Animal Health Laboratory, Private Bag 24, Geelong, Victoria 3220, Australia.
authors.forename: Andrew G D
authors.initials: AG
authors.lastname: Bean
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D001483:Base Sequence; D002645:Chickens / Q000378:metabolism* / Q000821:virology; D056426:Genetic Loci; D008024:Ligands; D008322:Mammals; D008969:Molecular Sequence Data; D010802:Phylogeny; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D040681:Structural Homology, Protein; D051193:Toll-Like Receptors / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics
chemical_list: D030161:Avian Proteins; D008024:Ligands; D012333:RNA, Messenger; D051193:Toll-Like Receptors
keywords: Avian influenza; Chicken; Interferon; Viperin