title: Surgical and systemic management of endometrial cancer: an international survey.
abstract: OBJECTIVE
  To ascertain the spectrum of clinical management of endometrial carcinoma (EC) the largest international survey was conducted to evaluate and identify differences worldwide.
  
  
  METHODS
  After validation of a 15-item questionnaire regarding surgical and adjuvant treatment of EC in Germany, an English-adapted questionnaire was put online and posted to all the major gynecological cancer Societies worldwide for further distribution commencing in 2010 and continued for 26 months.
  
  
  RESULTS
  A total of 618 Institutions around the world participated: Central Europe (CE), Southern Europe (SE), Northern Europe (NE), Asia and USA/Canada/UK. Both a therapeutic and staging value was attributed to systematic pelvic and paraaortic lymph node dissection (LND) in CE (74.6%) and in Asia (67.2%), as opposed to USA/UK where LND was mainly for staging purposes (53.5%; p < 0.001). LND was performed up to the renal veins in CE in 86.8%, in Asia in 80.8%, in USA/UK in 51.2% and in SE in 45.1% (p < 0.001) of cases. In advanced disease, centers from Asia were treated most with adjuvant chemotherapy alone (93.6%), as opposed to centers in SE, CE and UK/USA that employed combination chemo-radiotherapy in 90.9% (p < 0.001) of cases. Paclitaxel/carboplatin was mostly used followed by doxorubicin/cisplatin (75 vs. 23.3%; p < 0.001). In total, 94% of all participants supported the concept of treating EC patients within appropriate clinical trials.
  
  
  CONCLUSIONS
  There is broad range in both the surgical and adjuvant treatment of EC across different countries. Large-scale multicenter prospective trials are warranted to establish consistent, evidence-based guidelines to optimize treatment worldwide.
authors.affiliation: Frauenklinik, Universitätsklinik Charite, Campus Virchow, Berlin, Germany, chfotopoulou@gmail.com.
authors.forename: Christina
authors.initials: C
authors.lastname: Fotopoulou
authors.forename: Robert
authors.initials: R
authors.lastname: Kraetschell
authors.forename: Sean
authors.initials: S
authors.lastname: Dowdy
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.forename: Domenica
authors.initials: D
authors.lastname: Larusso
authors.forename: Antonio
authors.initials: A
authors.lastname: Casado
authors.forename: Sven
authors.initials: S
authors.lastname: Mahner
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Herzog
authors.forename: Sean
authors.initials: S
authors.lastname: Kehoe
authors.forename: Ignace
authors.initials: I
authors.lastname: Vergote
authors.forename: David Scott
authors.initials: DS
authors.lastname: Miller
authors.forename: Christian
authors.initials: C
authors.lastname: Marth
authors.forename: Shingo
authors.initials: S
authors.lastname: Fujii
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
mesh_terms: D000276:Adjuvants, Immunologic; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003944:Diagnostic Techniques, Obstetrical and Gynecological / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D016889:Endometrial Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D005006:Ethnicity; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data; D013509:Gynecologic Surgical Procedures / Q000706:statistics & numerical data; D006306:Health Surveys; D006801:Humans; D008197:Lymph Node Excision; D010818:Practice Patterns, Physicians'; D011364:Professional Practice / Q000592:standards / Q000706:statistics & numerical data*; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D000276:Adjuvants, Immunologic