title: Epstein-Barr virus (EBV)-positive sporadic burkitt lymphoma: an age-related lymphoproliferative disorder?
abstract: Epstein-Barr virus (EBV) is detected in 20% to 30% of sporadic Burkitt lymphoma (sBL). However, only a few studies of EBV-positive (EBV) sBL have been reported, and its characteristics still remain controversial. To highlight the features of EBV sBL, we compared the clinicopathologic characteristics of 33 cases of EBV and 117 cases of EBV-negative (EBV) sBL in Japan. EBV sBL showed significantly higher age distribution (median, 42 vs. 13 y; P<0.0001) and higher frequency of patients older than 50 years (48% vs. 16%, P<0.0001). We also revealed the difference of the involved sites. The EBV group showed significantly higher incidence of involvement of tonsil (P=0.027), adrenal gland (P=0.011), and cervical lymph node (P=0.040). In addition, the EBV group tended to have higher incidence of nodal involvement (P=0.078) and involvement of para-aorta lymph node (P=0.084) and heart (P=0.050). In contrast, the gastrointestinal tract was less frequently affected in EBV sBL (P=0.024). In addition, the less positivity for MUM1 (P=0.020) of EBV sBL was highlighted. These results indicate that biological behavior and pathogenesis of EBV sBL might be different from those of EBV sBL. Our results demonstrate that EBV sBL has an aspect of age-related disease and is a distinct clinicopathologic subtype, which should be distinguished from EBV sBL.
authors.affiliation: *Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya †Department of Clinical Laboratory, Nagano Prefectural Suzaka Hospital, Nagano ‡Department of Pathology ∥Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development **Department of Pathology, Tokai University School of Medicine, Tokyo §Japanese Pediatric Leukemia/Lymphoma Study Group ¶Department of Pediatrics, Aichi Medical University ‡‡Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Aichi #Department of Medical Oncology, Teine Keijinkai Hospital, Hokkaido Prefecture ††Department of Pathology, School of Medicine, Kurume University, Fukuoka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Satou
authors.forename: Naoko
authors.initials: N
authors.lastname: Asano
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
authors.forename: Tomoo
authors.initials: T
authors.lastname: Osumi
authors.forename: Masahito
authors.initials: M
authors.lastname: Tsurusawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishiguro
authors.forename: Ahmed Ali
authors.initials: AA
authors.lastname: Elsayed
authors.forename: Naoya
authors.initials: N
authors.lastname: Nakamura
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002051:Burkitt Lymphoma / Q000473:pathology* / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D055815:Young Adult