title: [Expression of FOXC1 and its relationship with E-cadherin in nasopharyngeal carcinoma tissues].
abstract: OBJECTIVE
  To investigate the significance and relationship between the expression of FOXC1 and clinicopathological features, and to explore its correlation with E-cadherin.
  
  
  METHODS
  Immunohistochemical SP method was used to detected the expression of FOXC1 in nasopharyngeal carcinoma tissues and nasopharyngitis tissues.
  
  
  RESULTS
  (1) Immunoreaction to FOXC1 was mainly located in nucleus of nasopharyngeal carcinoma cells. The positive expression rate of FOXC1 in nasopharyngeal carcinoma tissues was 85.3% (81/95), which was significantly higher than that in nasopharyngitis tissues (59.4%) (P < 0.05). (2) The expression of FOXC1 was not related to patients' age and gender, clinical stage of cancer and lymph node metastasis (P > 0.05). (3) There was a correlation between the expression of FOXC1 and down-regulated expression of E-cadherin in nasopharyngeal carcinoma tissues (P < 0.05).
  
  
  CONCLUSIONS
  FOXC1 may play an important role in generation and progression of nasopharyngeal carcinoma, there may be a correlation between the expression of FOXC1 and down-regulated expression of E-cadherin, also FOXC1 may play an important role in the process of EMT in nasopharyngeal carcinoma by regulating E-cadherin.
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Shengkui
authors.initials: S
authors.lastname: Tan
authors.forename: Shengjun
authors.initials: S
authors.lastname: Xiao
authors.forename: Shijiang
authors.initials: S
authors.lastname: Yi
authors.forename: Lei
authors.initials: L
authors.lastname: Ouyang
authors.forename: Qiaoyan
authors.initials: Q
authors.lastname: Hou
authors.forename: Weiming
authors.initials: W
authors.lastname: Xiong
authors.forename: Xun
authors.initials: X
authors.lastname: Lei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD; D015820:Cadherins / Q000378:metabolism*; D002277:Carcinoma; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009304:Nasopharyngitis / Q000378:metabolism; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; C112743:FOXC1 protein, human; D051858:Forkhead Transcription Factors