title: Perceptions of family history and genetic testing and feasibility of pedigree development among African Americans with hypertension.
abstract: BACKGROUND
  Pedigree development, family history, and genetic testing are thought to be useful in improving outcomes of chronic illnesses such as hypertension (HTN). However, the clinical utility of pedigree development is still unknown. Further, little is known about the perceptions of African Americans (AAs) of family history and genetic testing.
  
  
  OBJECTIVE
  This study examined the feasibility of developing pedigrees for AAs with HTN and explored perceptions of family history and genetic research among AAs with HTN.
  
  
  METHODS
  The US Surgeon General's My Family Health Portrait was administered, and 30-60 min in-person individual interviews were conducted. Descriptive statistics were used to analyze pedigree data. Interview transcripts were analyzed with content analysis and constant comparison.
  
  
  RESULTS
  Twenty-nine AAs with HTN were recruited from one free clinic (15 women, 14 men; mean age 49 years, standard deviation (SD) 9.6). Twenty-six (90%) reported their family history in sufficient detail to develop a pedigree. Perceptions of family history included knowledge of HTN in the family, culturally influenced family teaching about HTN, and response to family history of HTN. Most participants agreed to future genetic testing and DNA collection because they wanted to help others; some said they needed more information and others expressed a concern for privacy.
  
  
  CONCLUSIONS
  The majority of AAs in this sample possessed extensive knowledge of HTN within their family and were able to develop a three-generation pedigree with assistance. The majority were willing to participate in future genetic research.
authors.affiliation: College of Nursing, University of Arkansas for Medical Sciences, USA cpettey@uams.edu.
authors.forename: Christina M
authors.initials: CM
authors.lastname: Pettey
authors.affiliation: College of Nursing, University of Arkansas for Medical Sciences, USA.
authors.forename: Jean C
authors.initials: JC
authors.lastname: McSweeney
authors.affiliation: General Administration, University of North Carolina and Department of Public Health Sciences, University of North Carolina - Charlotte, USA.
authors.forename: Katharine E
authors.initials: KE
authors.lastname: Stewart
authors.affiliation: College of Pharmacy, University of Arkansas for Medical Sciences, USA.
authors.forename: Elvin T
authors.initials: ET
authors.lastname: Price
authors.affiliation: College of Medicine, University of Arkansas for Medical Sciences, USA.
authors.forename: Mario A
authors.initials: MA
authors.lastname: Cleves
authors.affiliation: College of Nursing, University of Arkansas for Medical Sciences, USA.
authors.forename: Seongkum
authors.initials: S
authors.lastname: Heo
authors.affiliation: College of Nursing, University of Arkansas for Medical Sciences, USA.
authors.forename: Elaine
authors.initials: E
authors.lastname: Souder
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001795:Blood Pressure Determination; D016000:Cluster Analysis; D005192:Family Health; D005240:Feasibility Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000208:ethnology*; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data; D010375:Pedigree; D010465:Perception; D012494:Sampling Studies; D012720:Severity of Illness Index; D014481:United States; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents
keywords: African Americans; Family history; blacks; genetic; pedigree