title: Pterostilbene attenuates the inflammatory reaction induced by ischemia/reperfusion in rat heart.
abstract: The role of pterostilbene (Pte) in inflammation induced by ischemia/reperfusion is not well understood. The aim of this study was to investigate whether Pte modulates neutrophil accumulation and the induction of tumor necrosis factor-α (TNF-α) in an ischemia/reperfusion (I/R)-injured rat heart model. Rats were randomly exposed to a sham operation, myocardial ischemia/reperfusion (MI/R) alone, MI/R+Pte, MI/R+Pte+L-NAME and MI/R+Pte+ (methylene blue) MB. The results demonstrated that compared with MI/R, Pte reduced the area of myocardial infarction, the levels of myocardial myeloperoxidase, serum creatinine kinase and lactate dehydrogenase, and the production of serum and myocardial TNF-α. These Pte-induced effects were eliminated by the administration of L-NAME, a nitric oxide (NO) synthase inhibitor, and MB, a cyclic guanosine monophosphate (cGMP) inhibitor. In conclusion, Pte produces cardioprotective and anti-inflammatory effects. These effects may be associated with an increase in NO production, the inhibition of neutrophil accumulation, and induction of TNF-α and cGMP signaling pathways in myocardium subjected to MI/R.
authors.affiliation: Department of Cardiovascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Min
authors.initials: M
authors.lastname: Lv
authors.affiliation: Department of Cardiovascular Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Kexiang
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Fu
authors.affiliation: Department of Cardiovascular Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pediatrics, The First Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.
authors.forename: Xia
authors.initials: X
authors.lastname: Yu
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003402:Creatine Kinase / Q000097:blood; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D020556:Neutrophil Infiltration / Q000187:drug effects; D051381:Rats; D013267:Stilbenes / Q000008:administration & dosage / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D013267:Stilbenes; D014409:Tumor Necrosis Factor-alpha; C107773:pterostilbene; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase