title: Effects of chicory inulin on serum metabolites of uric acid, lipids, glucose, and abdominal fat deposition in quails induced by purine-rich diets.
abstract: Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory inulin on serum metabolites of uric acid (UA), lipids, glucose, and abdominal fat deposition in quail model induced by a purine-rich diet. In this study, 60 male French quails were randomly allocated to five groups: CON (control group), MOD (model group), BEN (benzbromarone-treated group), CHI-H (high-dosage chicory inulin-treated group), and CHI-L (low-dosage chicory inulin-treated group). The serum UA level was significantly increased in the model group from days 7 to 28, as well as triglyceride (TG) and free fatty acid (FFA) increased later in the experimental period. The abdominal fat ratio was increased on day 28. Benzbromarone can decrease UA levels on days 14 and 28. The high and low dosage of chicory inulin also decreased serum UA levels on days 7, 14, and 28. The abdominal fat ratio, activity, and protein of acetyl-CoA carboxylase (ACC) were decreased in chicory inulin-treated groups. The activities of xanthine oxidase (XOD) and fatty acid synthase (FAS) were increased in the model group and decreased in the benzbromarone and chicory inulin groups. This study evaluated a quail model of induced hyperuricemia with other metabolic disorders caused by a high-purine diet. The results indicated that a purine-rich diet might contribute to the development of hyperuricemia, hypertriglyceridemia, and abdominal obesity. Chicory inulin decreased serum UA, TG, and abdominal fat deposition in a quail model of hyperuricemia by altering the ACC protein expression and FAS and XOD activities.
authors.affiliation: 1 Department of Clinical Chinese Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine , Beijing, China .
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Lin
authors.forename: Bing
authors.initials: B
authors.lastname: Zhang
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Jin
authors.forename: Wenjing
authors.initials: W
authors.lastname: Zhu
mesh_terms: D050153:Abdominal Fat / Q000378:metabolism*; D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D018651:Cichorium intybus / Q000737:chemistry*; D004032:Diet / Q000009:adverse effects; D004195:Disease Models, Animal; D015228:Hypertriglyceridemia / Q000139:chemically induced; D033461:Hyperuricemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007444:Inulin / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D008297:Male; D056128:Obesity, Abdominal / Q000139:chemically induced / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D011687:Purines / Q000009:adverse effects*; D011784:Quail; D014527:Uric Acid / Q000097:blood*; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D008055:Lipids; D010936:Plant Extracts; D011687:Purines; D014527:Uric Acid; D007444:Inulin; D014969:Xanthine Oxidase; D000103:Acetyl-CoA Carboxylase
keywords: abdominal fat deposition; blood lipids; chicory inulin; glucose; uric acid