title: A meta-analysis of the correlation between the HLA-DRB1*03 allele and chronic hepatitis B in the Han Chinese population.
abstract: OBJECTIVE
  This study sought to use a meta-analysis approach to comprehensively evaluate correlations between the human leukocyte antigen-DR beta 1 (HLA-DRB1)*03 allele and chronic hepatitis B (CHB) in the Han Chinese population.
  
  
  METHODS
  The China Biomedical Literature database (CBMdisc), the Chongqing VIP database (VIP), and the PubMed database were searched. Using the inclusion and exclusion criteria of this study, all relevant case-control studies retrieved in these searches that satisfied the conditions of this investigation were collected. Review Manager (RevMan) 5.2 software was used to conduct a meta-analysis on the results of these studies.
  
  
  RESULTS
  There were 9 publications that satisfied the inclusion criteria. These publications included a total of 970 cases in the CHB group and 1185 cases in the normal control group. Egger's test revealed no significant publication bias. A comprehensive analysis indicated that the pooled odds ratio (OR) value was 1.94 with a 95% confidence interval (CI) of 1.23-3.06 (Z=2.84, p=0.004); these findings suggested that in the Han Chinese population, the HLA-DRB1*03 allele is a susceptibility allele related to the occurrence of CHB.
  
  
  CONCLUSIONS
  There is a statistically significant correlation between the HLA-DRB1*03 allele and the occurrence of CHB in the Han Chinese population, and the HLA-DRB1*03 allele may be a susceptibility allele for this disease.
authors.affiliation: 1 Department of Infectious Disease, Linyi People's Hospital , Linyi, Shandong, People's Republic of China .
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li-Kun
authors.initials: LK
authors.lastname: Wang
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Wei
authors.forename: Jing-Wei
authors.initials: JW
authors.lastname: Wang
authors.forename: Cheng-Bao
authors.initials: CB
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
mesh_terms: D000483:Alleles; D044466:Asian People; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D008297:Male
chemical_list: D059811:HLA-DRB1 Chains