title: What is sensitive skin? A systematic literature review of objective measurements.
abstract: Despite sensitive skin being highly prevalent, no consensus on the definition and pathomechanism of sensitive skin exists. Here we report the results of a systematic literature review of diagnostic methods for sensitive skin at clinical, histological and biophysical levels. A systematic search revealed 27 out of 1,701 articles which we appraised in detail. Impaired skin barrier function and increased vascular reactivity are most often associated with sensitive skin. We identified key reasons causing an ambiguity around the sensitive skin phenomenon. We propose using standardized selection methods of subjects by a multifactorial questionnaire spanning a range of provocations, including those of chemical, mechanical and environmental origin, followed by clinical, histological and top-notch biophysical measurements. This could lead to a breakthrough in the understanding of the sensitive skin phenomenon, fueling advances of biomedical and dermatological science.
authors.affiliation: Department of Dermatology, Radboud University Medical Center (Radboudumc), Nijmegen, The Netherlands.
authors.forename: Renée
authors.initials: R
authors.lastname: Richters
authors.forename: Denise
authors.initials: D
authors.lastname: Falcone
authors.forename: Natallia
authors.initials: N
authors.lastname: Uzunbajakava
authors.forename: Willem
authors.initials: W
authors.lastname: Verkruysse
authors.forename: Piet
authors.initials: P
authors.lastname: van Erp
authors.forename: Peter
authors.initials: P
authors.lastname: van de Kerkhof
mesh_terms: D032921:Consensus; D006801:Humans; D011237:Predictive Value of Tests; D012307:Risk Factors; D012684:Sensory Thresholds; D012867:Skin / Q000503:physiopathology*; D012871:Skin Diseases / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000523:psychology; D011795:Surveys and Questionnaires; D009626:Terminology as Topic