title: NOTch just a bladder control problem.
abstract: Human bladder cancers harbor deletions and point mutations in genes coding for Notch receptors and proteins involved in Notch signaling. This leads to elevated MAPK pathway activation, as direct Notch-mediated transcription of MAPK phosphatase DUSP is lost. These bladder tumors, with impaired Notch signaling, also show basal differentiation.
authors.affiliation: Tumor Cell Biology Program, Cancer Institute, University of Mississippi Medical Center, Jackson, MS 39216, USA.
authors.forename: Keli
authors.initials: K
authors.lastname: Xu
authors.affiliation: Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
authors.forename: Darius J
authors.initials: DJ
authors.lastname: Bägli
authors.affiliation: Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada. Electronic address: segan@sickkids.ca.
authors.forename: Sean E
authors.initials: SE
authors.lastname: Egan
mesh_terms: D006801:Humans; D017354:Point Mutation; D051880:Receptors, Notch / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*
chemical_list: D051880:Receptors, Notch