title: Access to 4-alkylaminopyridazine derivatives via nitrogen-assisted regioselective Pd-catalyzed reactions.
abstract: 3-Substituted, 6-substituted, and unsymmetrical 3,6-disubstituted 4-alkylaminopyridazines were prepared from a sequence of three chemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactions, such as reductive dehalogenation and Suzuki-Miyaura reactions. Extension of the methodology to Sonogashira reaction yielded a novel class of 3-substituted pyrrolopyridazines.
authors.affiliation: Laboratoire d'Innovation Thérapeutique, UMR 7200, Faculté de Pharmacie, Université de Strasbourg , 74 Route du Rhin, BP 60024, 67400 Illkirch, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Blaise
authors.forename: Arthur E
authors.initials: AE
authors.lastname: Kümmerle
authors.forename: Hassan
authors.initials: H
authors.lastname: Hammoud
authors.forename: João Xavier
authors.initials: JX
authors.lastname: de Araújo-Júnior
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bihel
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Bourguignon
authors.forename: Martine
authors.initials: M
authors.lastname: Schmitt
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D011724:Pyridazines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D000588:Amines; D011724:Pyridazines; D011758:Pyrroles; C508945:Pyrrolopyridazine; D010165:Palladium; D009584:Nitrogen