title: A feasible strategy for focal cerebral ischemia-reperfusion injury: remote ischemic postconditioning.
abstract: It is difficult to control the degree of ischemic postconditioning in the brain and other ischemia-sensitive organs. Remote ischemic postconditioning could protect some ischemia-sensitive organs through measures on terminal organs. In this study, a focal cerebral ischemia-reperfusion injury model was established using three cycles of remote ischemic postconditioning, each cycle consisted of 10-minute occlusion of the femoral artery and 10-minute opening. The results showed that, remote ischemic postconditioning significantly decreased the percentage of the infarct area and attenuated brain edema. In addition, inflammatory nuclear factor-κB expression was significantly lower, while anti-apoptotic Bcl-2 expression was significantly elevated in the cerebral cortex on the ischemic side. Our findings indicate that remote ischemic postconditioning attenuates focal cerebral ischemia/reperfusion injury, and that the neuroprotective mechanism is mediated by an anti-apoptotic effect and reduction of the inflammatory response.
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China ; Department of Neurology, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Neurology, Qilu Hospital of Shandong University, Brain Science Research Institute of Shandong University, Jinan, Shandong Province, China.
authors.forename: Shengnian
authors.initials: S
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Yaodong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neurology, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Qi
authors.affiliation: Department of Neurology, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Neurology, Third Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning Province, China.
authors.forename: Siwei
authors.initials: S
authors.lastname: Long
keywords: Bcl-2; apoptosis; brain injury; focal cerebral ischemia; inflammation; nerve regeneration; neural regeneration; neuroprotection; nuclear factor-κB; remote ischemic postconditioning