title: Antiproliferative prenylated xanthones and benzophenones from the roots of Cudrania tricuspidata in HSC-T6 cells.
abstract: Four new prenylated xanthones, cudracuspixanthones A-D (1-4), two new prenylated benzophenones, cudracuspiphenones A (5) and B (6), and 11 known xanthones (7-17) were isolated from the roots of Cudrania tricuspidata. The absolute configurations of compounds 2-4 were deduced by the comparison of the calculated optical rotation values with the measured data. Compounds 1, 5, and 6 showed moderate antiproliferative activity on HSC-T6 cells with IC50 values of 9.7, 3.3, and 7.1 μM, respectively. Compounds 2-4, 10, and 14-16 had weaker activity. Flow cytometric analysis suggested that compounds 1 and 5 inhibited HSC-T6 cell proliferation in part by inducing apoptosis.
authors.affiliation: College of Pharmacy, Chungbuk National University , Cheongju 361-763, Korea.
authors.forename: Yang Hee
authors.initials: YH
authors.lastname: Jo
authors.forename: Bora
authors.initials: B
authors.lastname: Shin
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Ki Yong
authors.initials: KY
authors.lastname: Lee
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation; D056910:Republic of Korea; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D001577:Benzophenones; D044004:Xanthones