title: Identifying predictors of early growth response and adverse radiation effects of vestibular schwannomas to radiosurgery.
abstract: OBJECTIVE
  To determine whether pre-treatment growth rate of vestibular schwannomas (VS) predict response to radiosurgery.
  
  
  METHODS
  A retrospective review of a prospectively maintained database of all VS patients treated with 12Gy prescription dose between September 2005 and June 2011 at our institution using the Leksell Model 4C Gamma Knife Unit was conducted. Patients who had a minimum of 12-months clinical and radiological assessment before and after radiosurgery were included in this study. Tumor growth rates were calculated using specific growth rate (SGR). Tumor volumes were measured on FIESTA-MRI scans using ITK-SNAP v2.2.
  
  
  RESULTS
  Following radiosurgery, twenty-seven (42.9%) patients showed a significant decrease in volume after one year, twenty-nine (46.0%) stabilized, and seven (11.1%) continued to grow. There was no correlation between VS pre-treatment SGRs with post-treatment SGRs (p = 0.34), and incidence of adverse radiation effects (ARE). The reduction in tumors' SGRs after radiosurgery was proportional to pre-treatment SGRs, although this correlation was not statistically significant (p = 0.19). Analysis of risk factors revealed a positive correlation between post-treatment SGRs and incidence of non-auditory complications, most of which were attributed to ARE (p = 0.047).
  
  
  CONCLUSIONS
  Pre-treatment growth rate of VS does not predict tumor response to radiosurgery or incidence of ARE. VS with higher SGRs post-radiosurgery are more likely to experience ARE.
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Soroush
authors.initials: S
authors.lastname: Larjani
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Eric
authors.initials: E
authors.lastname: Monsalves
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Houman
authors.initials: H
authors.lastname: Pebdani
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Boris
authors.initials: B
authors.lastname: Krischek
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Fred
authors.initials: F
authors.lastname: Gentili
authors.affiliation: Department of Neurosurgery, St. Michael's Hospital, Toronto, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Cusimano
authors.affiliation: Radiation Oncology Program, Princess Margaret Hospital, Toronto, Canada.
authors.forename: Normand
authors.initials: N
authors.lastname: Laperriere
authors.affiliation: Department of Neurosurgery, The Walton Centre, Liverpool, United Kingdom.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hayhurst
authors.affiliation: Department of Neurosurgery, University Health Network, Toronto, Canada.
authors.forename: Gelareh
authors.initials: G
authors.lastname: Zadeh
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology / Q000556:secondary*; D011832:Radiation Injuries / Q000453:epidemiology; D016634:Radiosurgery / Q000009:adverse effects*; D012189:Retrospective Studies; D016896:Treatment Outcome; D047368:Tumor Burden