title: Terpenoids from the root bark of Pterolobium macropterum.
abstract: Five new compounds, including pteroloterins A-C (1, 3, and 4), 1β-acetoxytaepeenin C (2), and 8aα-hydroxycadinenal (5), and 11 known compounds were isolated from the root bark of Pterolobium macropterum. All compounds were evaluated for cytotoxicity against the cholangiocarcinoma cell lines. Compound 9 showed weak cytotoxicity against the KKU-M139 cell line with an IC50 value of 23.24 ± 0.18 μM and showed no activity against normal cells.
authors.affiliation: Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, and §Department of Microbiology, Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University , Khon Kaen 40002, Thailand.
authors.forename: Jittra
authors.initials: J
authors.lastname: Suthiwong
authors.forename: Siripit
authors.initials: S
authors.lastname: Pitchuanchom
authors.forename: Wareeporn
authors.initials: W
authors.lastname: Wattanawongdon
authors.forename: Chariya
authors.initials: C
authors.lastname: Hahnvajanawong
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D045744:Cell Line, Tumor; D018281:Cholangiocarcinoma; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010012:Osteogenesis / Q000187:drug effects; D024301:Plant Bark / Q000737:chemistry; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013785:Thailand
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes