title: Impact of MDM2 single nucleotide polymorphism on oral squamous cell carcinoma risk.
abstract: Mouse Double Minute 2 (MDM2) has emerged as a pivotal cellular antagonist of p53 by destructing the suppressive function of p53 against tumorigenesis. The MDM2 309 T > G polymorphism has been studied for its association with oral squamous cell carcinoma (OSCC) susceptibility, but the evidence was confusing and inconclusive. Here, we performed a meta-analysis to estimate the effects of the 309 T > G polymorphism on the development of OSCC. The relevant studies were searched on both PubMed and Embase. We estimated the risk of OSCC using odds ratio (OR) and 95 % confidence interval (CI). In addition, between-study heterogeneity was measured by the χ (2)-based statistic test; sensitivity analysis, and the funnel plots and Egger's test were also performed in this meta-analysis. Based on five case-control studies with a total of 1,369 OSCC cases and 2,167 control subjects, the meta-analysis result showed neither increased nor decreased risk of OSCC associated with any genetic model of the 309 T > G polymorphism. Similar results were observed in the subgroup of Asians. No significant heterogeneity and publication bias were detected in the meta-analysis. The evidence provided in our study indicated that the 309 T > G polymorphism might have no significant contribution to susceptibility toward OSCC.
authors.affiliation: School of Stomatology, Shandong University, Wenhuaxi Road, Jinan, 250012, Shandong, China.
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Xie
authors.forename: Jing-Lei
authors.initials: JL
authors.lastname: Yang
authors.forename: De-Sheng
authors.initials: DS
authors.lastname: Liu
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Xie
authors.forename: Ping
authors.initials: P
authors.lastname: Ji
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*
chemical_list: D051736:Proto-Oncogene Proteins c-mdm2