title: Hormone therapy and risk of cardiovascular outcomes and mortality in women treated with statins.
abstract: OBJECTIVE
  This work aims to study the effects of hormone therapy (HT) on the risk of cardiovascular outcomes and all-cause mortality in women treated with statins.
  
  
  METHODS
  We included women aged 40 to 74 years and living in Sweden who filled a first statin prescription between 2006 and 2007. Women were categorized as HT users or as nonusers. Information on dispensed drugs, comorbidity, cardiovascular outcomes, and all-cause mortality was obtained from national health registers.
  
  
  RESULTS
  A total of 40,958 statin users--2,862 (7%) HT users and 38,096 nonusers--were followed for a mean of 4.0 years. In total, 70% of the women used statins as primary prevention. Among HT users, there were five cardiovascular deaths per 10,000 person-years. The corresponding rate among nonusers was 18, which yielded a hazard ratio of 0.38 (95% CI, 0.12-1.19). The all-cause mortality rates were 33 and 87, respectively, and the hazard ratio was 0.53 (95% CI, 0.34-0.81). There were no associations with cardiovascular events. A similar pattern was found for both primary and secondary prevention.
  
  
  CONCLUSIONS
  HT is associated with a reduced risk of all-cause mortality in women treated with statins. Although confounding factors, such as lifestyle and disease severity, might have influenced the results, HT does not seem to be detrimental to statin-treated women.
authors.affiliation: From the Center for Pharmacoepidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Ingegärd Anveden
authors.initials: IA
authors.lastname: Berglind
authors.forename: Morten
authors.initials: M
authors.lastname: Andersen
authors.forename: Anna
authors.initials: A
authors.lastname: Citarella
authors.forename: Marie
authors.initials: M
authors.lastname: Linder
authors.forename: Anders
authors.initials: A
authors.lastname: Sundström
authors.forename: Helle
authors.initials: H
authors.lastname: Kieler
mesh_terms: D002423:Cause of Death; D003327:Coronary Disease / Q000401:mortality* / Q000517:prevention & control*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors