title: O-GlcNAcylation, an Epigenetic Mark. Focus on the Histone Code, TET Family Proteins, and Polycomb Group Proteins.
abstract: There are increasing evidences that dietary components and metabolic disorders affect gene expression through epigenetic mechanisms. These observations support the notion that epigenetic reprograming-linked nutrition is connected to the etiology of metabolic diseases and cancer. During the last 5 years, accumulating data revealed that the nutrient-sensing O-GlcNAc glycosylation (O-GlcNAcylation) may be pivotal in the modulation of chromatin remodeling and in the regulation of gene expression by being part of the "histone code," and by identifying OGT (O-GlcNAc transferase) as an interacting partner of the TET family proteins of DNA hydroxylases and as a member of the polycomb group proteins. Thus, it is suggested that O-GlcNAcylation is a post-translational modification that links nutrition to epigenetic. This review summarizes recent findings about the interplay between O-GlcNAcylation and the epigenome and enlightens the contribution of the glycosylation to epigenetic reprograming.
authors.affiliation: Structural and Functional Glycobiology Unit, Lille 1 University , Villeneuve d'Ascq , France ; Institut de Biologie de Lille, Pasteur Institute of Lille, Université Lille Nord de France , Lille , France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Dehennaut
authors.affiliation: Institut de Biologie de Lille, Pasteur Institute of Lille, Université Lille Nord de France , Lille , France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Leprince
authors.affiliation: Structural and Functional Glycobiology Unit, Lille 1 University , Villeneuve d'Ascq , France.
authors.forename: Tony
authors.initials: T
authors.lastname: Lefebvre
keywords: O-GlcNAcylation; OGT; TET family proteins; cancer; epigenetic; histones; polycomb