title: [Comparative study of discriminative stimulus properties of antidepressants].
abstract: Interoceptive stimulus properties of amitriptyline (54 mg/kg body weight), fluoxetine (10 mg/kg), and pyrrolo[1,2-a][1,4]diazepine derivative GMAL-24 (10 mg/kg) were studied in a standard operant model with liquid reinforcement of drug discrimination (DD) in male Wistar rats. A new experimental schedule that includes subchronic (7-day) administration of a training drug was used to perform DD learning. For the first time, it was found that amitriptyline has a discriminative interoceptive stimulus properties. Neither fluoxetine nor GMAL-24 did exhibit interoceptive properties. Imipramine (15 mg/kg, i.p.) fully substitutes for amitriptyline stimulus in substitution test. Fluoxetine (5 - 20 mg/kg, i.p.) failed to substitute with amitriptyline. Thus, amitriptyline/saline drug discrimination should be used for a comparative analysis of the central mechanisms of action of psychotropic substances, rather than for screening specific antidepressant activity.
authors.forename: A O
authors.initials: AO
authors.lastname: Korolev
authors.forename: T S
authors.initials: TS
authors.lastname: Kalinina
authors.forename: A V
authors.initials: AV
authors.lastname: Volkova
authors.forename: G V
authors.initials: GV
authors.lastname: Mokrov
authors.forename: N V
authors.initials: NV
authors.lastname: Kudriashov
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000928:Antidepressive Agents