title: [B lymphocytes: a promising target to treat atherosclerosis?].
abstract: Atherosclerosis is a chronic inflammatory disease of the arterial wall. It is already well established that several immune cells (macrophages, T lymphocytes, etc.) modulate atherosclerosis progression whereas the role of the different subpopulations of B lymphocytes emerged only recently. B1 lymphocytes secrete protective IgM antibodies that act as scavenger of deleterious molecules whereas B2 lymphocytes probably worsen the disease by activating pro-inflammatory T lymphocytes. The outcome of these opposite functional properties of B lymphocytes on the evolution of arterial lesions may vary depending on their local environment during the different stages of the disease. In this review, we emphasize recent progresses in understanding the specific contribution of B lymphocytes to atherosclerosis and discuss the interest of targeting them to improve therapy.
authors.affiliation: Centre de pharmacologie et d'innovation dans le diabète, EA 7288, Faculté de pharmacie, 15, avenue Charles Flahault, 34093 Montpellier, France - Institut de biologie et de -technologies de Saclay (iBiTec-S), service d'ingénierie moléculaire des protéines (SIMOPRO), centre CEA Saclay-Gif-sur-Yvette, 91191 Gif-sur-Yvette Cedex, France.
authors.forename: Moustafa
authors.initials: M
authors.lastname: Hamze
authors.affiliation: Centre de pharmacologie et d'innovation dans le diabète, EA 7288, Faculté de pharmacie, 15, avenue Charles Flahault, 34093 Montpellier, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Desmetz
authors.affiliation: Dynamique des interactions membranaires normales et pathologiques (DIMNP), UMR 5235 CNRS, Université Montpellier II, place Eugène Bataillon, 34095 Montpellier Cedex 5, France.
authors.forename: Paul
authors.initials: P
authors.lastname: Guglielmi
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000628:therapy*; D001402:B-Lymphocytes / Q000502:physiology*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods / Q000639:trends