title: Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(II) complexes.
abstract: Platinum complexes, bearing aliphatic amines and phosphine ligands in trans configuration with iodide as leaving groups, are synthesized and characterized. The crystal structure of trans-PtI2(isopropylamine)(PPh3) is reported. The complex bearing isopropylamine is demonstrated to be the best candidate as its cytotoxic activity is comparable to or better than cisplatin. A remarkably higher interaction of the complexes with DNA is reported as compared to the parent chlorido series. Cell cycle studies of the complexes in six human cell lines are performed and also compared with the previous series.
authors.affiliation: Department of Inorganic Chemistry, Universidad Autónoma de Madrid, C/Francisco Tomas y Valiente 7.M7, 28049 Madrid, Spain. adoracion.gomez@uam.es.
authors.forename: Angeles
authors.initials: A
authors.lastname: Medrano
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Dennis
authors.forename: Amparo
authors.initials: A
authors.lastname: Alvarez-Valdés
authors.forename: Josefina
authors.initials: J
authors.lastname: Perles
authors.forename: Tracey
authors.initials: T
authors.lastname: McGregor Mason
authors.forename: Adoracion G
authors.initials: AG
authors.lastname: Quiroga
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry*; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D008968:Molecular Conformation; D010720:Phosphines / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D010720:Phosphines; D010984:Platinum; D004247:DNA; C044646:phosphine