title: Review of experimental attempts of islet allotransplantation in rodents: parameters involved and viability of the procedure.
abstract: The purpose of the present study was to organize the parameters involved in experimental allotransplantation in rodents to elaborate the most suitable model to supply the scarcity of islet donors. We used the PubMed database to systematically search for published articles containing the keywords "rodent islet transplantation" to review. We included studies that involved allotransplantation experiments with rodents' islets, and we reviewed the reference lists from the eligible publications that were retrieved. We excluded articles related to isotransplantation, autotransplantation and xenotransplantation, i.e., transplantation in other species. A total of 25 studies related to allotransplantation were selected for systematic review based on their relevance and updated data. Allotransplantation in rodents is promising and continues to develop. Survival rates of allografts have increased with the discovery of new immunosuppressive drugs and the use of different graft sites. These successes suggest that islet transplantation is a promising method to overcome the scarcity of islet donors and advance the treatment options for type 1 diabetes.
authors.affiliation: Leandro Ryuchi Iuamoto, Alberto Meyer, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Sao Paulo 05403-090, Brazil.
authors.forename: Leandro Ryuchi
authors.initials: LR
authors.lastname: Iuamoto
authors.affiliation: Leandro Ryuchi Iuamoto, Alberto Meyer, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Sao Paulo 05403-090, Brazil.
authors.forename: Alberto
authors.initials: A
authors.lastname: Meyer
authors.affiliation: Leandro Ryuchi Iuamoto, Alberto Meyer, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Sao Paulo 05403-090, Brazil.
authors.forename: Eleazar
authors.initials: E
authors.lastname: Chaib
authors.affiliation: Leandro Ryuchi Iuamoto, Alberto Meyer, Eleazar Chaib, Luiz Augusto Carneiro D'Albuquerque, Department of Gastroenterology, Liver and Pancreas Transplantation Surgery Unit, University of Sao Paulo, Sao Paulo 05403-090, Brazil.
authors.forename: Luiz Augusto Carneiro
authors.initials: LA
authors.lastname: D'Albuquerque
mesh_terms: D064591:Allografts; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control; D006085:Graft Survival / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects; D051379:Mice; D051381:Rats; D014022:Tissue Survival
chemical_list: D007166:Immunosuppressive Agents
keywords: Allograft; Diabetes mellitus; Hyperglycemia; Immunosuppression; Islet; Islet grafts; Islet transplantation; Type 1 diabetes