title: Oxidative tandem nitrosation/cyclization of N-aryl enamines with nitromethane toward 3-(trifluoromethyl)quinoxalines.
abstract: A novel one-pot strategy for the synthesis of 3-trifluoromethylquinoxalines from N-aryl enamines and nitromethane was developed. The tandem reaction is achieved through nitrosation of alkenes, tautomerization and cyclization, which can be applicable to a wide range of enamines with excellent functional group tolerance and afford quinoxalines in moderate to good yields.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China. zxg@wzu.edu.cn.
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Chuan-Zhuo
authors.initials: CZ
authors.lastname: Liu
authors.forename: Bo-Lun
authors.initials: BL
authors.lastname: Hu
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Deng
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D003500:Cyclization; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D009595:Nitroparaffins / Q000737:chemistry*; D015538:Nitrosation; D010084:Oxidation-Reduction; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D009595:Nitroparaffins; D011810:Quinoxalines; D008697:Methane; C008640:nitromethane