title: Autologous immune enhancement therapy in Philadelphia chromosome positive acute lymphoblastic leukemia.
abstract: Advances in current treatment regimens in childhood acute lymphoblastic leukemia (ALL) have resulted in cure rates of 75-80 %. Some molecular genetic abnormalities confer a poor prognosis. Of these, the chromosomal translocation t (9;22)-Philadelphia chromosome is associated with the worst outcome in childhood ALL. Optimal therapy for this variant of ALL includes chemotherapy as per high risk schedule, imatinib and early stem cell transplantation. We report here the successful natural killer cell-based autologous immune enhancement therapy along with chemotherapy and imatinib in a patient with Philadelphia chromosome positive ALL.
authors.affiliation: Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, India.
authors.forename: Revathi
authors.initials: R
authors.lastname: Raj
authors.affiliation: Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, India.
authors.forename: M
authors.initials: M
authors.lastname: Deenadayalan
authors.affiliation: Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, India.
authors.forename: G
authors.initials: G
authors.lastname: Vimal Kumar
authors.affiliation: Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, India.
authors.forename: Vipin
authors.initials: V
authors.lastname: Khandelwal
authors.affiliation: Pediatric Hematology, Oncology and Marrow Transplantation Unit, Apollo Speciality Hospitals, Chennai, India.
authors.forename: Karuna
authors.initials: K
authors.lastname: Sri
authors.affiliation: Nichi-In Centre for Regenerative Medicine, PB 2278, Chennai, 600026 India.
authors.forename: Rajappa
authors.initials: R
authors.lastname: Senthilkumar
authors.affiliation: Faculty of Medicine, Yamanashi University, Chuo, 409-3898 Japan.
authors.forename: Samuel J K
authors.initials: SJ
authors.lastname: Abraham
authors.affiliation: Biotherapy Institute of Japan, Tokyo, 135-0051 Japan.
authors.forename: Terunuma
authors.initials: T
authors.lastname: Hiroshi