title: Inducamides A-C, chlorinated alkaloids from an RNA polymerase mutant strain of Streptomyces sp.
abstract: Inducamides A-C (1-3), three new chlorinated alkaloids featuring an amide skeleton generated by a tryptophan fragment and a 6-methylsalicylic acid unit, were isolated from a chemically induced mutant strain of Streptomyces sp. with the inducamides only being produced in the mutant strain. Their structures, including stereochemistry, were determined by spectroscopic analysis, Marfey's method, and CD spectroscopy.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas , Dallas, Texas 75390, United States.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Matthew
authors.initials: M
authors.lastname: Jamison
authors.forename: Scott
authors.initials: S
authors.lastname: La
authors.forename: John B
authors.initials: JB
authors.lastname: MacMillan
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry*; D054879:Halogenation; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000577:Amides; D026121:Indole Alkaloids; C000594876:inducamide A; C000594877:inducamide B; C000594878:inducamide C; D012321:DNA-Directed RNA Polymerases