title: Spheroform: therapeutic spheroid-forming nanotextured surfaces inspired by desert beetle Physosterna cribripes.
abstract: An approach is presented to create arrays of quasi-spherical microdroplets by surfaces called "spheroform" inspired by micro-/nanostructures found in the back of the Namib desert beetle. Spheroform is fabricated by microarray formation of catecholamine polymers on the superhydrophobic background. Spheroform is able to precisely control spheroid sizes of therapeutic islet cells and mesenchymal stem cells. The therapeutic spheroids exhibit improved biochemical activities.
authors.affiliation: Department of Chemistry, Center for Nature-inspired Technology in KINC, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea.
authors.forename: Mihyun
authors.initials: M
authors.lastname: Lee
authors.forename: Kisuk
authors.initials: K
authors.lastname: Yang
authors.forename: Yong Hwa
authors.initials: YH
authors.lastname: Hwang
authors.forename: Youngro
authors.initials: Y
authors.lastname: Byun
authors.forename: Dong Yun
authors.initials: DY
authors.lastname: Lee
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Cho
authors.forename: Haeshin
authors.initials: H
authors.lastname: Lee
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000627:therapeutic use*; D001517:Coleoptera / Q000033:anatomy & histology*; D006801:Humans; D007515:Islets of Langerhans / Q000166:cytology; D059630:Mesenchymal Stem Cells / Q000166:cytology; D049329:Nanostructures / Q000627:therapeutic use*; D018874:Spheroids, Cellular / Q000166:cytology*; D013499:Surface Properties
keywords: desert beetles; islet cells; mesenchymal stem cells; polydopamine; therapeutic spheroids