title: Uptake from water, internal distribution and bioaccumulation of selenium in Scenedesmus obliquus, Unio mancus and Rattus norvegicus: part A.
abstract: The (75)Se internal bioavailability was investigated in microalgae, mussels and rats as biological experimental models. The (75)Se accumulation from freshwater to microalgae [Scenedesmus obliquus (Turpin) Kützing], from freshwater to mussels (Unio mancus Lamark) and, finally, per os to rats (Rattus norvegicus Berkenhout) was followed using (75)Se-labelled selenite looking at (75)Se uptake, retention, intracellular distribution and binding with cellular biocomplexes. After exposure to 10, 50 and 500 μg Se L(-1), the microalgae showed an inhibitory effect on population growth only at the highest concentration. Mussels exposed to 105 μg Se L(-1) showed an accumulation of the element with time in all tissues. Intracellularly, Se was present in all subcellular fractions, especially in the cytosol. Rats were treated via oral administration with 5 μg Se rat(-1). After 24 h, liver and kidney showed the highest Se concentration.
authors.affiliation: Medicine and Public Health, University of Verona, P.le L.A. Scuro 10, Policlinico Borgoroma Verona, 37134, Verona, Italy.
authors.forename: Aldo-Eliano
authors.initials: AE
authors.lastname: Polettini
authors.forename: Salvador
authors.initials: S
authors.lastname: Fortaner
authors.forename: Massimo
authors.initials: M
authors.lastname: Farina
authors.forename: Flavia
authors.initials: F
authors.lastname: Groppi
authors.forename: Simone
authors.initials: S
authors.lastname: Manenti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Libralato
authors.forename: Enrico
authors.initials: E
authors.lastname: Sabbioni
mesh_terms: D000818:Animals; D005618:Fresh Water / Q000737:chemistry; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D058086:Microalgae / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044444:Scenedesmus / Q000378:metabolism*; D012643:Selenium / Q000032:analysis* / Q000493:pharmacokinetics*; D018036:Selenium Compounds / Q000378:metabolism; D013347:Subcellular Fractions; D014018:Tissue Distribution; D049881:Unio / Q000378:metabolism*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D018036:Selenium Compounds; D014874:Water Pollutants, Chemical; D012643:Selenium