title: The Yin and Yang of inflammation.
abstract: Inflammation is an essential protective part of the body's response to infection, yet many diseases are the product of inflammation. For example, inflammation can lead to autoimmune disease and tissue damage, and is a key element in chronic health conditions such as heart disease, diabetes, rheumatoid arthritis, and also drives changes associated with aging. Animal models of infectious and chronic disease are important tools with which to dissect the pathways whereby inflammatory responses are initiated and controlled. Animal models therefore provide a prism through which the role of inflammation in health and disease can be viewed, and are important means by which to dissect mechanisms and identify potential therapies to be tested in the clinic. A meeting, "The Yin and Yang of Inflammation" was organized by Trudeau Institute and was held between April 4-6, 2014. The main goal was to bring together experts from biotechnology and academic organizations to examine and describe critical pathways in inflammation and place these pathways within the context of human disease. A group of ~80 scientists met for three days of intense formal and informal exchanges. A key focus was to stimulate interactions between basic research and industry.
authors.forename: M A
authors.initials: MA
authors.lastname: Blackman
authors.forename: J L
authors.initials: JL
authors.lastname: Yates
authors.forename: C M
authors.initials: CM
authors.lastname: Spencer
authors.forename: E E
authors.initials: EE
authors.lastname: Vomhof-DeKrey
authors.forename: A M
authors.initials: AM
authors.lastname: Cooper
authors.affiliation: Trudeau Institute, Saranac Lake, NY 12983, USA. mblackman@trudeauinstitute.org.
authors.forename: E A
authors.initials: EA
authors.lastname: Leadbetter
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism; D064307:Microbiota / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators