title: Metal-ligand binding interactions in rhodium/palladium-catalyzed synthesis of dihydroquinolines.
abstract: A domino Rh- and Pd-catalyzed synthesis of dihydroquinolines is disclosed. Two metals and two ligands are placed in one reaction vessel along with the two reactive reagents to afford selective sequential coupling despite the potential for side reactions. In this report, we describe mechanistic investigations attempting to discern the catalyst-ligand interactions occurring in this domino reaction. Through these studies, the reactivity and relative catalyst ligand loadings were successfully tuned to efficiently access the heterocyclic products.
authors.affiliation: Davenport Research Laboratories, Department of Chemistry, University of Toronto , 80 St George St., Toronto, Ontario, Canada , M5S 3H6.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Jane
authors.initials: J
authors.lastname: Panteleev
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D006873:Hydroquinones / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006873:Hydroquinones; D008024:Ligands; D010165:Palladium; D012238:Rhodium