title: Evaluation of the analgesic effect of subcutaneous methadone after cesarean section.
abstract: BACKGROUND
  Inadequate pain control has a significant role in maternal and neonatal health in early post-partum period which interferes with breastfeeding and has a negative influence on child normal growth. The aim of this study is evaluation of subcutaneous methadone effectiveness on post-operative pain control.
  
  
  METHODS
  Double blind randomized prospective clinical trial involving 60 term pregnancy patients through 2008 to 2009 Undergo cesarean.
  
  
  METHODS
  Prime gravid candidate of elective cesarean and spinal anesthesia class 1 or 2. Known case of drug allergy and methadone interaction, addiction, uncontrolled medical disease excluded. Case group injected 10 mg of subcutaneous methadone in the site of incision before final suture. Morphine was a pain reliever in follow up examination. Data include mean of pain, nausea and vomiting, MAP, etc., collected and analyzed by independent-T test and Man Whitney test.
  
  
  RESULTS
  Although mean usage of morphine between groups was not significant statistically but the mean pain severity (P value < 0.05) and mean satisfactory (P value = 0.02) was statistically significant between groups. Other parameters were not statistically significant.
  
  
  CONCLUSIONS
  We suggest subcutaneous methadone as a safe pain reliever in post cesarean section patients.
authors.affiliation: Anesthesia and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Jabalameli
authors.affiliation: Department of Anesthesia, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Forough
authors.initials: F
authors.lastname: Kalantari
keywords: Cesarean; morphine; pain control; subcutaneous methadone