title: Construct and assess multimodal mouse brain connectomes via joint modeling of multi-scale DTI and neuron tracer data.
abstract: Mapping the neuronal wiring diagrams in the brain at multiple spatial scales has been one of the major brain mapping objectives. Macro-scale medical imaging modalities such as diffusion tensor imaging (DTI) and meso-scale biological imaging such as serial two-photon tomography have emerged as the prominent tools to reveal structural connectivity patterns at multiple scales. However, a significant gap that whether/how DTI data and microscopic data are correlated with each other for the s ame species of mammalian brains,e.g., mouse brains, has been rarely explored. To bridge this knowledge gap, this work aims to construct multi-modal mouse brain connectomes via joint modeling of macro-scale DTI data and meso-scale neuronal tracing data. Specifically, the high-resolution DTI data and its streamline tractography result are mapped to the Allen Mouse Brain Atlas, in which the high-density axonal projections were already mapped by microscopic serial two-photon tomography. Then, multi-modal connectomes were constructed and the multi-view spectral clustering method is employed to assess consistent and discrepant connectivity patterns across the multi-scale multi-modal connectomes. Experimental results demonstrated the importance of fusing multimodal, multi-scale imaging modalities for structural connectivity and connectome mapping.
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Hongmiao
authors.initials: H
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Kuang
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Joe Z
authors.initials: JZ
authors.lastname: Tsien
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000166:cytology*; D003198:Computer Simulation; D063132:Connectome / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D051379:Mice; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods*; D008959:Models, Neurological; D015233:Models, Statistical; D064847:Multimodal Imaging / Q000379:methods; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique