title: Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.
abstract: OBJECTIVE
  Though exposure to organochlorine pollutants (OCPs) is considered a risk factor for type 2 diabetes (T2DM), epidemiological evidence for the association remains controversial. A systematic review and meta-analysis was applied to quantitatively evaluate the association between exposure to OCPs and incidence of T2DM and pool the inconsistent evidence.
  
  
  METHODS
  Publications in English were searched in MEDLINE and WEB OF SCIENCE databases and related reference lists up to August 2013. Quantitative estimates and information regarding study characteristics were extracted from 23 original studies. Quality assessments of external validity, bias, exposure measurement and confounding were performed, and subgroup analyses were conducted to examine the heterogeneity sources.
  
  
  RESULTS
  We retrieved 23 eligible articles to conduct this meta-analysis. OR (odds ratio) or RR (risk ratio) estimates in each subgroup were discussed, and the strong associations were observed in PCB-153 (OR, 1.52; 95% CI, 1.19-1.94), PCBs (OR, 2.14; 95% CI, 1.53-2.99), and p,p'-DDE (OR, 1.33; 95% CI, 1.15-1.54) based on a random-effects model.
  
  
  CONCLUSIONS
  This meta-analysis provides quantitative evidence supporting the conclusion that exposure to organochlorine pollutants is associated with an increased risk of incidence of T2DM.
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Mengling
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Epidemiology & Health Statistics, School of Public Health, Zhejiang University, Hangzhou, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Fangxing
authors.initials: F
authors.lastname: Yang
authors.affiliation: MOE Key Laboratory of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Liu
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000473:pathology; D004787:Environmental Pollution; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D050356:Lipid Metabolism / Q000187:drug effects; D012307:Risk Factors
chemical_list: D006843:Hydrocarbons, Chlorinated