title: Cytotoxic biflavones from Stellera chamaejasme.
abstract: Bioassay-guided phytochemical studies on Stellera chamaejasme led to the isolation of two new biflavones, chamaejasmenin E (1) and chamaejasmin D (2), together with ten known compounds. The structures of new compounds were elucidated by extensive spectroscopic analyses and their absolute configurations on 2, 3, 2″ and 3″ were confirmed by TDDFT quantum chemical calculated ECD spectra combined with experimental ECD spectra. All isolated biflavones were evaluated for their cytotoxic activities against Bel-7402 and A549 tumor cell lines, and sikokianin D (3) was found to possess the most potential cytotoxic activities against both the two cell lines with IC50 values of 1.29 ± 0.21 and 0.75 ± 0.25 μM, respectively. Moreover, some structure-function relationships of these bioflavones for cytotoxic activities were explored and summarized.
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Zhi-xin
authors.initials: ZX
authors.lastname: Wang
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Meng-chun
authors.initials: MC
authors.lastname: Cheng
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Xiao-zhe
authors.initials: XZ
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Zhi-lai
authors.initials: ZL
authors.lastname: Hong
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Ming-zhe
authors.initials: MZ
authors.lastname: Gao
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Xiao-xi
authors.initials: XX
authors.lastname: Kan
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Ya-jie
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: zhuxx59@163.com.
authors.forename: Xiao-xin
authors.initials: XX
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: hbxiao@dicp.ac.cn.
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Xiao
mesh_terms: D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification; D045744:Cell Line, Tumor; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013329:Structure-Activity Relationship; D029645:Thymelaeaceae / Q000737:chemistry*
chemical_list: D044946:Biflavonoids; D047309:Flavones; C000597710:chamaejasmenin E; C000597711:chamaejasmin D
keywords: Chamaejasmenin E; Chamaejasmin D; Cytotoxic activity; ECD; Stellera chamaejasme