title: Predictive factors of survival time of breast cancer in kurdistan province of Iran between 2006-2014: a cox regression approach.
abstract: BACKGROUND
  Breast cancer is the most common cancer and the second most common cause of cancer-induced mortalities in Iranian women, following gastric carcinoma. The survival of these patients depends on several factors, which are very important to identify in order to understand the natural history of the disease.
  
  
  METHODS
  In this retrospective study, 313 consecutive women with pathologically-proven diagnosis of breast cancer who had been treated during a seven-year period (January 2006 until March 2014) at Towhid hospital, Sanandaj city, Kurdistan province of Iran, were recruited. The Kaplan-Meier method was used for data analysis, and finally those factors that showed significant association on univariate analysis were entered in a Cox regression model.
  
  
  RESULTS
  the mean age of patients was 46.10±10.81 years. Based on Kaplan-Meier method median of survival time was 81 months and 5 year survival rate was 75%±0.43. Tumor metastasis (HR=9.06, p=0.0001), relapse (HR=3.20, p=0.001), clinical stage of cancer (HR=2.30, p=0.03) and place of metastasis (p=0.0001) had significant associations with the survival rate variation. Patients with tumor metastasis had the lowest five-year survival rate (37%)and among them patients who had brain metastasis were in the worst condition (5 year survival rate= 11%±0.10).
  
  
  CONCLUSIONS
  Our findings support the observation that those women with higher stages of breast malignancies (especially with metastatic cancer) have less chance of surviving the disease. Furthermore, screening programs and early detection of breast cancer may help to increase the survival of those women who are at risk of breast cancer.
authors.affiliation: Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran E-mail : alidelpisheh@yahoo.com.
authors.forename: Asrin
authors.initials: A
authors.lastname: Karimi
authors.forename: Ali
authors.initials: A
authors.lastname: Delpisheh
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sayehmiri
authors.forename: Hojjatollah
authors.initials: H
authors.lastname: Saboori
authors.forename: Ezzatollah
authors.initials: E
authors.lastname: Rahimi
mesh_terms: D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D001932:Brain Neoplasms / Q000401:mortality* / Q000556:secondary / Q000601:surgery; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D055815:Young Adult