title: [Impact of loop diuretics on blood sodium in patients hospitalized for heart failure].
abstract: OBJECTIVE
  To observe the level of blood sodium in patients hospitalized for heart failure with water-sodium retention treated with loop diuretics and risk factors of low blood sodium.
  
  
  METHODS
  We selected 1 378 acute decompensated heart failure patients who visited Anzhen Hospital, and they are treated with loop diuretics, 259 patients with weight loses more than 1 kg in one week was enrolled in the final analysis, and divided into 3 groups: Group A (weight reduction between 1-3 kg), Group B (weight reduction between 3-5 kg) and Group C (weight reduction over 5 kg). Blood sodium, creatinine and uric acid were compared among groups and risk factors of low blood sodium were analyzed.
  
  
  RESULTS
  Blood sodium was similar before and post loop diuretics treatment in Group A, and reduced in group B ((138.28 ± 3.73) mmol/L vs. (139.34 ± 3.66) mmol/L, P < 0.05) and in Group C((137.60 ± 4.07) mmol/L vs. (139.44 ± 4.12) mmol/L, P < 0.05). Forty-six (17.8%) patients developed hyponatremia post loop diuretics treatment. Duration of loop diuretics use was the independent risk infector for hyponatremia (OR = 1.191, 95%CI 1.010-1.385).
  
  
  CONCLUSIONS
  Loop diuretics use is safe for treating hospitalized patients for heart failure with water-sodium retention and the risk of developing hyponatremia is low. Duration of loop diuretics use is the independent risk factor of hyponatremia.
authors.affiliation: Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Guan
authors.affiliation: Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China. Email: wuxuesi@263.net.
authors.forename: Xuesi
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Anzhen Hospital, Capital Medical University, Beijing 100029, China.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Wu
mesh_terms: D000208:Acute Disease; D003404:Creatinine; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007010:Hyponatremia; D012307:Risk Factors; D012964:Sodium / Q000097:blood; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012982:Sodium, Dietary
chemical_list: D049994:Sodium Potassium Chloride Symporter Inhibitors; D012982:Sodium, Dietary; D012964:Sodium; D003404:Creatinine