title: Mold-templated inorganic-organic hybrid supraparticles for codelivery of drugs.
abstract: This paper reports a facile and robust mold-templated technique for the assembly of mesoporous silica (MS) supraparticles and demonstrates their potential as vehicles for codelivery of brain-derived neurotrophic factor (BDNF) and dexamethasone (DEX). The MS supraparticles are assembled using gelatin as a biodegradable adhesive to bind and cross-link the particles. Microfabricated molds made of polydimethylsiloxane are used to control the size and shape of the supraparticles. The obtained mesoporous silica-gelatin hybrid supraparticles (MSG-SPs) are stable in water as well as in organic solvents, such as dimethyl sulfoxide, and efficiently coencapsulate both BDNF and DEX. The MSG-SPs also exhibit sustained release kinetics in simulated physiological conditions (>30 days), making them potential candidates for long-term delivery of therapeutics to the inner ear.
authors.affiliation: ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, ‡Department of Chemical and Biomolecular Engineering, §Department of Otolaryngology, and ∥Department of Medical Bionics, The University of Melbourne , Parkville, Victoria 3010, Australia.
authors.forename: James W
authors.initials: JW
authors.lastname: Maina
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.forename: Mattias
authors.initials: M
authors.lastname: Björnmalm
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Wise
authors.forename: Robert K
authors.initials: RK
authors.lastname: Shepherd
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000737:chemistry*; D003907:Dexamethasone / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D003907:Dexamethasone