title: A novel aggregation-induced emission based fluorescent probe for an angiotensin converting enzyme (ACE) assay and inhibitor screening.
abstract: A 'turn-on' fluorescent probe based on aggregation-induced emission (AIE) has been developed. It exhibits excellent selectivity and sensitivity for monitoring angiotensin converting enzyme (ACE) activity both in solutions and in living cells as well as for screening ACE inhibitors in vitro.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University (Zijingang Campus), Hangzhou, 310058, P. R. China. mysky@zju.edu.cn.
authors.forename: Haibo
authors.initials: H
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhao
authors.forename: Wan
authors.initials: W
authors.lastname: Gong
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D001681:Biological Assay; D015374:Biosensing Techniques; D002216:Captopril / Q000494:pharmacology*; D005030:Ethylenes / Q000737:chemistry / Q000494:pharmacology*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D019073:HT29 Cells; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D013234:Stem Cells / Q000187:drug effects / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D005030:Ethylenes; D005456:Fluorescent Dyes; D009842:Oligopeptides; D002216:Captopril; D007703:Peptidyl-Dipeptidase A; D013755:Tetradecanoylphorbol Acetate