title: Benzodiazepine administration prevents the use of error-correction mechanisms during fear extinction.
abstract: Three experiments examined the effect of systemic administration of the benzodiazepine midazolam on extinction and re-extinction of conditioned fear. Experiment 1 demonstrated that midazolam administration prior to extinction of a conditioned stimulus (CS) impaired that extinction when rats were subsequently tested drug free; however, extinction was spared if rats were extinguished, reconditioned, and re-extinguished under midazolam. Experiment 2 provided a replication of this effect within-subjects; rats were conditioned to two CSs (A and B), extinguished to one (A-), reconditioned to both, and then extinguished/re-extinguished to both stimuli in compound (AB-), under either vehicle or midazolam. On the drug-free test, rats given midazolam froze more to the CS that had been extinguished (B) than the one that been re-extinguished (A). The final experiment examined whether extinction under midazolam was regulated by prediction error. Rats were trained with three CSs (A, B, C) and extinguished to two (A-, C-). These stimuli then underwent additional extinction under midazolam or vehicle, with one CS now presented in compound with the non-extinguished CS (AB-, C-). Rats were then tested for fear of A relative to C. Rats given vehicle showed a deepening of extinction to A relative to C, as is predicted from error-correction models; however, rats given midazolam failed to show any such discrepancy in responding. The results are interpreted to indicate that the drug reduced prediction error during extinction by reducing fear, and rats were able to re-extinguish fear via a retrieval mechanism that is independent of prediction error.
authors.affiliation: School of Psychology, University of New South Wales, Sydney, NSW, 2052, Australia.
authors.forename: Genevra
authors.initials: G
authors.lastname: Hart
authors.forename: Nathan M
authors.initials: NM
authors.lastname: Holmes
authors.forename: Justin A
authors.initials: JA
authors.lastname: Harris
authors.forename: R Frederick
authors.initials: RF
authors.lastname: Westbrook
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D005239:Fear / Q000187:drug effects*; D008874:Midazolam / Q000494:pharmacology*; D051381:Rats
chemical_list: D001569:Benzodiazepines; D008874:Midazolam