title: Increased functional connectivity strength of right inferior temporal gyrus in first-episode, drug-naive somatization disorder.
abstract: BACKGROUND
  Evidence of brain structural and functional alterations have been implicated in patients with somatization disorder (SD). However, little is known about brain functional connectivity in SD. In the present study, resting-state functional magnetic resonance imaging (fMRI) and graph theory were used to obtain a comprehensive view of whole-brain functional connectivity and to investigate the changes of voxel-wise functional networks in patients with SD.
  
  
  METHODS
  Twenty-five first-episode, medication-naive patients with SD and 28 age-, sex- and education-matched healthy controls (HCs) underwent resting-state fMRI. The graph theory approach was employed to analyze the data.
  
  
  RESULTS
  Compared to the HCs, patients with SD showed significantly increased functional connectivity strength in the right inferior temporal gyrus (ITG). There is a significant positive correlation between the z-values of the cluster in the right ITG and Hamilton Anxiety Scale scores.
  
  
  CONCLUSIONS
  Our findings indicate that there is a disruption of the functional connectivity pattern in the right ITG in first-episode, treatment-naive patients with SD, which bears clinical significance.
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Qinji
authors.initials: Q
authors.lastname: Su
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Yao
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Muliang
authors.initials: M
authors.lastname: Jiang
authors.affiliation: Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jiajing
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Mental Health Institute, The 303rd Hospital of Chinese People's Liberation Army, Nanning, Guangxi, China.
authors.forename: Chunxing
authors.initials: C
authors.lastname: Xu
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Miaoyu
authors.initials: M
authors.lastname: Yu
authors.affiliation: Department of Radiology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Liling
authors.initials: L
authors.lastname: Long
authors.affiliation: Mental Health Institute, The 303rd Hospital of Chinese People's Liberation Army, Nanning, Guangxi, China.
authors.forename: Hongzheng
authors.initials: H
authors.lastname: Li
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jianrong
authors.initials: J
authors.lastname: Liu
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Zhikun
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Mental Health Center, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, China guowenbin76@163.com.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Guo
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013001:Somatoform Disorders / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology*
keywords: Functional connectivity strength; graph theory; inferior temporal gyrus; somatization disorder