title: Beneficial effects of dietary EGCG and voluntary exercise on behavior in an Alzheimer's disease mouse model.
abstract: Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder affecting specific brain regions that control memory and cognitive functions. Epidemiological studies suggest that exercise and dietary antioxidants are beneficial in reducing AD risk. To date, botanical flavonoids are consistently associated with the prevention of age-related diseases. The present study investigated the effects of 4 months of wheel-running exercise, initiated at 2-months of age, in conjunction with the effects of the green tea catechin (-)-epigallocatechin-3-gallate (EGCG) administered orally in the drinking water (50 mg/kg daily) on: (1) behavioral measures: learning and memory performance in the Barnes maze, nest building, open-field, anxiety in the light-dark box; and (2) soluble amyloid-β (Aβ) levels in the cortex and hippocampus in TgCRND8 (Tg) mice. Untreated Tg mice showed hyperactivity, relatively poor nest building behaviors, and deficits in spatial learning in the Barnes maze. Both EGCG and voluntary exercise, separately and in combination, were able to attenuate nest building and Barnes maze performance deficits. Additionally, these interventions lowered soluble Aβ1-42 levels in the cortex and hippocampus. These results, together with epidemiological and clinical studies in humans, suggest that dietary polyphenols and exercise may have beneficial effects on brain health and slow the progression of AD.
authors.affiliation: Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Walker
authors.affiliation: Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Diana
authors.initials: D
authors.lastname: Klakotskaia
authors.affiliation: Department of Biochemistry, University of Missouri, Columbia, MO, USA Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
authors.forename: Deepa
authors.initials: D
authors.lastname: Ajit
authors.affiliation: Department of Biochemistry, University of Missouri, Columbia, MO, USA Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Weisman
authors.affiliation: Department of Pharmacology, University of Minnesota, Geriatric Research Education and Clinical Center, VAMC, Minneapolis, MN, USA.
authors.forename: W Gibson
authors.initials: WG
authors.lastname: Wood
authors.affiliation: Department of Biochemistry, University of Missouri, Columbia, MO, USA Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, USA Center for Translational Neuroscience, University of Missouri, Columbia, MO, USA.
authors.forename: Grace Y
authors.initials: GY
authors.lastname: Sun
authors.affiliation: Department of Biochemistry, University of Missouri, Columbia, MO, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Serfozo
authors.affiliation: Department of Biochemistry, University of Missouri, Columbia, MO, USA Center for Translational Neuroscience, University of Missouri, Columbia, MO, USA.
authors.forename: Agnes
authors.initials: A
authors.lastname: Simonyi
authors.affiliation: Department of Psychological Sciences, University of Missouri, Columbia, MO, USA.
authors.forename: Todd R
authors.initials: TR
authors.lastname: Schachtman
mesh_terms: D000284:Administration, Oral; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D004195:Disease Models, Animal; D060766:Drinking Water; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D006799:Housing, Animal; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009043:Motor Activity / Q000502:physiology*; D018697:Nootropic Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000378:metabolism
chemical_list: C545487:APP protein, human; D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D060766:Drinking Water; D018697:Nootropic Agents; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D002392:Catechin; C045651:epigallocatechin gallate
keywords: Alzheimer's disease; AβPP transgenic mice; EGCG; behavior; exercise; learning