title: The association of openness personality trait with stress-related salivary biomarkers in burning mouth syndrome.
abstract: BACKGROUND
  Burning mouth syndrome (BMS) is a chronic disorder defined as a burning sensation in the oral mucosa without evidence of pathological findings. Its pathophysiology is largely unknown, but psychiatric disorders and personality traits have been implicated.
  
  
  OBJECTIVE
  This study investigated whether there is any association between salivary biomarkers and personality traits in BMS patients.
  
  
  METHODS
  It was a cross-sectional, controlled study that evaluated 30 individuals with BMS and 32 controls. All subjects were assessed with a structured psychiatric interview (Mini International Neuropsychiatric Interview) and the Big Five inventory. Salivary levels of brain-derived neurotrophic factor (BDNF), neural growth factor, tumor necrosis factor-α, interleukin (IL)-6, IL-10 and cortisol were determined.
  
  
  RESULTS
  We found that BMS patients exhibited more traits of neuroticism and lower openness than controls. Openness showed a moderate and negative correlation with cortisol, BDNF and IL-6.
  
  
  CONCLUSIONS
  Personality traits are associated with salivary biomarkers in BMS.
authors.affiliation: Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Fabrício T A
authors.initials: FT
authors.lastname: de Souza
authors.forename: Arthur
authors.initials: A
authors.lastname: Kummer
authors.forename: Maiza L V
authors.initials: ML
authors.lastname: Silva
authors.forename: Tânia M P
authors.initials: TM
authors.lastname: Amaral
authors.forename: Evandro N
authors.initials: EN
authors.lastname: Abdo
authors.forename: Mauro H N G
authors.initials: MH
authors.lastname: Abreu
authors.forename: Tarcília A
authors.initials: TA
authors.lastname: Silva
authors.forename: Antônio L
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000368:Aged; D001008:Anxiety Disorders / Q000503:physiopathology*; D015415:Biomarkers / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002054:Burning Mouth Syndrome / Q000378:metabolism* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000378:metabolism; D000075384:Neuroticism; D010551:Personality / Q000502:physiology*; D012463:Saliva / Q000737:chemistry; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; C579455:BDNF protein, human; D020932:Nerve Growth Factor; D006854:Hydrocortisone