title: Looking for virtuous promiscuity: electrocardiographic evidence of multichannel drug block.
abstract: The finding of QTc prolongation often sounds the death knell for a new molecule, but investigators have long suspected that QTc prolongation alone may be an indifferent predictor of risk. Premature or inappropriate rejection of promising molecules deprives clinicians of new therapies and depletes industry resources. Could it be that the conventional electrocardiogram contains information that might prevent us from relegating "virtuous" compounds to a fate they do not deserve?
authors.affiliation: Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Haigney
mesh_terms: D000083:Acetanilides / Q000009:adverse effects*; D000072237:ERG1 Potassium Channel; D004562:Electrocardiography / Q000187:drug effects*; D051638:Ether-A-Go-Go Potassium Channels / Q000037:antagonists & inhibitors*; D006801:Humans; D010627:Phenethylamines / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D026902:Potassium Channel Blockers / Q000009:adverse effects*; D011802:Quinidine / Q000009:adverse effects*; D000069458:Ranolazine; D013449:Sulfonamides / Q000009:adverse effects*; D014700:Verapamil / Q000009:adverse effects*
chemical_list: D000083:Acetanilides; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; D010627:Phenethylamines; D010879:Piperazines; D026902:Potassium Channel Blockers; D013449:Sulfonamides; D000069458:Ranolazine; D014700:Verapamil; D011802:Quinidine; C063533:dofetilide