title: Proteomic identification of altered cerebral proteins in the complex regional pain syndrome animal model.
abstract: BACKGROUND
  Complex regional pain syndrome (CRPS) is a rare but debilitating pain disorder. Although the exact pathophysiology of CRPS is not fully understood, central and peripheral mechanisms might be involved in the development of this disorder. To reveal the central mechanism of CRPS, we conducted a proteomic analysis of rat cerebrum using the chronic postischemia pain (CPIP) model, a novel experimental model of CRPS.
  
  
  METHODS
  After generating the CPIP animal model, we performed a proteomic analysis of the rat cerebrum using a multidimensional protein identification technology, and screened the proteins differentially expressed between the CPIP and control groups. Results. A total of 155 proteins were differentially expressed between the CPIP and control groups: 125 increased and 30 decreased; expressions of proteins related to cell signaling, synaptic plasticity, regulation of cell proliferation, and cytoskeletal formation were increased in the CPIP group. However, proenkephalin A, cereblon, and neuroserpin were decreased in CPIP group.
  
  
  CONCLUSIONS
  Altered expression of cerebral proteins in the CPIP model indicates cerebral involvement in the pathogenesis of CRPS. Further study is required to elucidate the roles of these proteins in the development and maintenance of CRPS.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 463707, Republic of Korea.
authors.forename: Francis Sahngun
authors.initials: FS
authors.lastname: Nahm
authors.affiliation: School of Life Science, Gwangju Institute of Science and Technology, Gwangju 500712, Republic of Korea.
authors.forename: Zee-Yong
authors.initials: ZY
authors.lastname: Park
authors.affiliation: Laboratory of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 143701, Republic of Korea.
authors.forename: Sang-Soep
authors.identifier: 0000-0002-0519-580X
authors.initials: SS
authors.lastname: Nahm
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul 110744, Republic of Korea.
authors.forename: Yong Chul
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam 463707, Republic of Korea.
authors.forename: Pyung Bok
authors.identifier: 0000-0003-0325-3356
authors.initials: PB
authors.lastname: Lee
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology; D054022:Cerebrum / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D020918:Complex Regional Pain Syndromes / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D008297:Male; D017288:Pain Threshold; D040901:Proteomics / Q000379:methods*; D017207:Rats, Sprague-Dawley