title: Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions.
abstract: A fast and efficient protocol for the formation of amides from low nucleophilic amines and esters in flow is described. Products were obtained in good to excellent yields and with the advantage of simultaneous mixing of all reagents at once, avoiding steps for intermediate formation. The protocol is also suitable to be combined with ester synthesis, resulting in the preparation of amides in-line from haloarenes.
authors.affiliation: University of Leuven, Department of Chemistry, Molecular Design and Synthesis, Celestijnenlaan 200F, box 2404, BE3001 Heverlee, Belgium. wim.deborggraeve@chem.kuleuven.be.
authors.forename: Johannes L
authors.initials: JL
authors.lastname: Vrijdag
authors.forename: Francisca
authors.initials: F
authors.lastname: Delgado
authors.forename: Nerea
authors.initials: N
authors.lastname: Alonso
authors.forename: Wim M
authors.initials: WM
authors.lastname: De Borggraeve
authors.forename: Natalia
authors.initials: N
authors.lastname: Pérez-Macias
authors.forename: Jesus
authors.initials: J
authors.lastname: Alcázar
mesh_terms: D015761:4-Aminopyridine / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters
chemical_list: D000577:Amides; D004952:Esters; D015761:4-Aminopyridine