title: Diffuse large B cell lymphoma in wiskott-Aldrich syndrome: a case report and review of literature.
abstract: Wiskott-Aldrich syndrome (WAS) is an X linked rare primary immunodeficiency syndrome with an increased propensity for infection, autoimmunity and malignancy. Here we report a male child, who was diagnosed with WAS at 1 year of age following evaluation for symptomatic thrombocytopenia and eczematous skin lesions. He presented later with lymphadenopathy, which was consistent with diffuse large B cell lymphoma on histopathology. He received 6 cycles of R-CHOP chemotherapy for the same and is presently in remission after 6 months. We review the major publications of lymphoma in WAS and discuss the pathological findings, treatment and prognosis of lymphoma in WAS.
authors.affiliation: Department of Clinical Haematology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Jayastu
authors.initials: J
authors.lastname: Senapati
authors.affiliation: Department of Clinical Haematology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Anup J
authors.initials: AJ
authors.lastname: Devasia
authors.affiliation: Department of Clinical Haematology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Sachin
authors.initials: S
authors.lastname: David
authors.affiliation: Department of General Pathology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Marie Therese
authors.initials: MT
authors.lastname: Manipadam
authors.affiliation: Department of General Pathology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Sheila
authors.initials: S
authors.lastname: Nair
authors.affiliation: Department of Clinical Haematology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Giridhara R
authors.initials: GR
authors.lastname: Jayandharan
authors.affiliation: Department of Clinical Haematology, Christian Medical College and Hospital, Vellore, 632004 India.
authors.forename: Biju
authors.initials: B
authors.lastname: George
keywords: Diffuse large B cell lymphoma; Primary immunodeficiency syndrome; Wiskott-Aldrich syndrome