title: Association between angiotensin I-converting enzyme gene polymorphism and susceptibility to cancer: a meta analysis.
abstract: BACKGROUND
  Angiotensin I-converting enzyme (ACE) gene plays an important role in the pathogenesis of cancers. The association between ACE insertion/deletion (I/D) polymorphism and the risk of various cancers has been studied. However, the results of these studies remain conflicting. Therefore, we performed a meta-analysis to evaluate the association between ACE I/D polymorphism and the risk of cancers.
  
  
  METHODS
  PubMed, Embase, ScienceDirect, Springer, CNKI, Wanfang, Weipu, CBM databases and Google Scholar were searched for case-control studies on ACE I/D polymorphism and the risk of cancers, published up to Dec 31, 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association between ACE I/D polymorphism and cancer risk.
  
  
  RESULTS
  Thirty-five published studies with 5007 cases and 8173 controls were included. Overall, there were no significant association between ACE I/D polymorphism and the risk of cancers (II vs. ID+DD OR = 1.05, 95% CI = 0.89-1.23, I vs. D OR = 1.00, 95% CI = 0.89-1.13). However, when stratified by ethnicity, we found a significant association between this polymorphism and cancer risk in Caucasians (II vs. ID+DD: OR = 1.43, 95% CI = 1.02-2.00, I vs. D: OR = 1.23, 95% CI 1.01-1.49).
  
  
  CONCLUSIONS
  ACE I/D polymorphism is associated with the cancer risk in Caucasians.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
authors.forename: Kan
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Cheng
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Yi
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
authors.forename: Huimin
authors.initials: H
authors.lastname: Shi
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China ; Key Laboratory of Respiratory Diseases, National Health and Family Planning Commission of the People's Republic of China Wuhan, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Zhen
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
keywords: ACE I/D; cancer risk; meta-analysis; single nucleotide polymorphism