title: Use of transrenal DNA for the diagnosis of extrapulmonary tuberculosis in children: a case of tubercular otitis media.
abstract: The diagnosis of tuberculosis (TB) is difficult in children, especially for smear-negative pulmonary and extrapulmonary TB, which are common at this age. We report an 11-year-old girl with TB otitis media with negative smear microscopy and Xpert MTB/RIF but positive Mycobacterium tuberculosis-specific transrenal DNA (Tr-MTB-DNA) test results and culture for M. tuberculosis.
authors.affiliation: Paediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Petrucci
authors.affiliation: Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy g.lombardi@unibo.it.
authors.forename: Giulia
authors.initials: G
authors.lastname: Lombardi
authors.affiliation: Paediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Corsini
authors.affiliation: Paediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Visciotti
authors.affiliation: Audiology and Otology Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pirodda
authors.affiliation: Paediatric Unit, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cazzato
authors.affiliation: Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Landini
authors.affiliation: Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Monte
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D004269:DNA, Bacterial / Q000235:genetics / Q000652:urine; D005260:Female; D006801:Humans; D010033:Otitis Media / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial