title: Prophylactic intravenous immunoglobulin injections to mothers with primary cytomegalovirus infection.
abstract: The aim of this trial study was to assess the preventive efficacy of immunoglobulin with a high titer of anti-CMV antibody for mother-to-fetus cytomegalovirus (CMV) transmission among pregnant women with primary/acute CMV infection. The primary CMV infection in mothers was diagnosed by a positive test for CMV IgM and/or low IgG avidity. Intact type immunoglobulin with a high titer of anti-CMV antibody was injected intravenously at a dosage of 2.5-5.0 g/day for consecutive 3 days to mothers with primary CMV infection. Four pregnant women were enrolled. One pregnancy ended in no congenital infection, while two pregnancies ended in congenital CMV infection. The other one pregnancy was terminated. The mother-to-fetus CMV transmission rate was found to be high as 66.7% (2/3). This preliminary result suggests that intravenous immunoglobulin injections are not effective for the prevention of mother-to-fetus CMV transmission in the present protocol.
authors.affiliation: Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanimura
authors.forename: Shinya
authors.initials: S
authors.lastname: Tairaku
authors.forename: Masashi
authors.initials: M
authors.lastname: Deguchi
authors.forename: Ayako
authors.initials: A
authors.lastname: Sonoyama
authors.forename: Mayumi
authors.initials: M
authors.lastname: Morizane
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ebina
authors.forename: Ichiro
authors.initials: I
authors.lastname: Morioka
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000008:administration & dosage; D000915:Antibody Affinity; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000151:congenital / Q000517:prevention & control / Q000635:transmission*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000517:prevention & control*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous
keywords: Cytomegalovirus (CMV); Immunoglobulin; Intrauterine infection; Prophylaxis