title: A new lignan glycoside from the aerial parts and cytotoxic investigation of Uvaria rufa.
abstract: Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in comparison with the reported data. A cytotoxic analysis of U. rufa herb extracts was performed for the first time using nine human cancer cell lines (MCF-7, MDA-MB-231, LNCaP, MKN7, SW480, KB, LU-1, HepG2 and HL-60) derived from different tumour types. Of these seven constituents, compounds 2 and 3 displayed moderate cytotoxicity against the human lung adenocarcinoma cell line (LU-1) with IC50 values of 9.22 ± 1.02 μg/mL and 10.21 ± 1.16 μg/mL, respectively.
authors.affiliation: a Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University , 06 Ngo Quyen Street, Hue City , Vietnam.
authors.forename: Thi Hoai
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Viet Duc
authors.initials: VD
authors.lastname: Ho
authors.forename: Thi Thao
authors.initials: TT
authors.lastname: Do
authors.forename: Huu Tai
authors.initials: HT
authors.lastname: Bui
authors.forename: Van Kiem
authors.initials: VK
authors.lastname: Phan
authors.forename: Katrin
authors.initials: K
authors.lastname: Sak
authors.forename: Ain
authors.initials: A
authors.lastname: Raal
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D045744:Cell Line, Tumor; D002783:Cholestenones; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D006027:Glycosides; D017705:Lignans; D010936:Plant Extracts; C015860:ergosta-4,6,8(14),22-tetraen-3-one
keywords: Annonaceae; Uvaria rufa; cytotoxicity; lignan glycoside; ufaside