title: Westerdijkin A, a new hydroxyphenylacetic acid derivative from deep sea fungus Aspergillus westerdijkiae SCSIO 05233.
abstract: A new methyl 2-(4-((2-hydroxy-3-methylbut-3-en-1-yl)oxy)phenyl) acetate 1, together with five known compounds 2-6, was isolated from the culture of the deep sea-derived fungus Aspergillus westerdijkiae SCSIO 05233. The new structure was determined by NMR ((1)H and (13)C NMR, HSQC, HMBC and MS) and optical rotation analysis. Compound 5 displayed weak inhibitory activities towards K562 and promyelocytic HL-60 with IC50 values of 25.8 and 44.9 μM, and compound 6 showed strong antifouling activity with EC50 value 8.81 μg/mL.
authors.affiliation: a Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , P.R. China.
authors.forename: Mangaladoss
authors.initials: M
authors.lastname: Fredimoses
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Wen
authors.initials: W
authors.lastname: Ai
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Tian
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Xiuping
authors.initials: X
authors.lastname: Lin
authors.forename: Jia-Yun
authors.initials: JY
authors.lastname: Xian
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification; D001230:Aspergillus / Q000737:chemistry*; D057219:Biofouling / Q000517:prevention & control; D018922:HL-60 Cells; D006801:Humans; D020014:K562 Cells; D015394:Molecular Structure; D010648:Phenylacetates / Q000737:chemistry* / Q000302:isolation & purification; D012623:Seawater / Q000382:microbiology; D014871:Water Microbiology
chemical_list: D000903:Antibiotics, Antineoplastic; D010648:Phenylacetates; C000596500:westerdijkin A
keywords: Aspergillus westerdijkiae; antifouling; cytotoxicity; deep sea