title: Ambulatory arterial stiffness index correlates with ambulatory pulse pressure but not dipping status in patients with grade 1/grade 2 essential hypertension.
abstract: OBJECTIVE
  To evaluate the relationship between ambulatory arterial stiffness index (AASI) and other parameters derived from ambulatory blood pressure (BP) monitoring, including dipping status, in patients with grade 1/grade 2 hypertension.
  
  
  METHODS
  This retrospective analysis included baseline data from Chinese outpatients enrolled into a previous study, who had clinic diastolic BP of 90-109 mmHg and systolic BP <180 mmHg, had undergone 24-h ambulatory BP monitoring and routine blood chemistry investigations, and had estimated glomerular filtration rate (eGFR) data.
  
  
  RESULTS
  Out of 120 patients screened, 87 were included. No significant difference in 24-h AASI was found between dippers and nondippers. The 24-h AASI significantly correlated with age, systolic BP and pulse pressure, and inversely correlated with 24-h diastolic BP variation and eGFR. In dippers and nondippers, AASI correlated with daytime pulse pressure, daytime diastolic BP variation and eGFR; in nondippers, AASI also correlated with 24-h systolic BP and 24-h pulse pressure. The 24-h AASI was significantly associated with 24-h pulse pressure and daytime pulse pressure.
  
  
  CONCLUSIONS
  In patients with grade 1/grade 2 essential hypertension, AASI shows a significant correlation with ambulatory pulse pressure.
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Tingli
authors.initials: T
authors.lastname: Qin
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Jiao
authors.affiliation: Department of Cardiology, China-Japan Friendship Hospital, Beijing, China keyuannan6666@aliyun.com.
authors.forename: Yuannan
authors.initials: Y
authors.lastname: Ke
authors.affiliation: Department of Cardiology, People's Hospital, Peking University, Beijing, China.
authors.forename: Ningling
authors.initials: N
authors.lastname: Sun
authors.affiliation: Centre for Epidemiological Studies and Clinical Trials, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Jiguang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Junren
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D000075222:Essential Hypertension; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D059289:Vascular Stiffness / Q000502:physiology*; D055815:Young Adult
keywords: Ambulatory blood pressure monitoring; ambulatory arterial stiffness index; blood pressure variability; morning blood pressure surge; pulse pressure