title: Microbicides and their potential as a catalyst for multipurpose sexual and reproductive health technologies.
abstract: There is an urgent need for technologies to prevent sexual acquisition of HIV infection in young women in sub-Saharan Africa. After two decades of 11 pivotal trials of seven products, anti-retroviral-based topical microbicides are showing promise. Building on the CAPRISA 004 trial findings, several trials of new anti-viral agents, novel delivery mechanisms and combination/multipurpose products that address challenges of adherence and meet the sexual and reproductive health needs of men and women, including preventing HIV infection, are underway.
authors.affiliation: CAPRISA-Centre for the AIDS Programme of Research in South Africa, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Department of Epidemiology, Columbia University, New York, NY, USA.
authors.forename: Q Abdool
authors.initials: QA
authors.lastname: Karim
authors.forename: C
authors.initials: C
authors.lastname: Baxter
authors.forename: S Abdool
authors.initials: SA
authors.lastname: Karim
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D063065:Organophosphonates / Q000008:administration & dosage*; D060728:Reproductive Health; D000068698:Tenofovir; D016387:Women's Health
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D005782:Gels; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine
keywords: HIV prevention; microbicide; tenofovir gel; women