title: Granulomatous tubulointerstitial nephritis secondary to omeprazole.
abstract: Drug-induced interstitial nephritis is a common cause of acute kidney injury indicated by elevated serum creatinine. We report a case of omeprazole-induced acute granulomatous interstitial nephritis (GIN). Our patient developed acute GIN secondary to omeprazole ingestion requiring haemodialysis. Treatment with steroids and withdrawal of omperazole was successful allowing the patient to discontinue haemodialysis in 3 months. She remains dialysis free with chronic kidney disease stage IV, reflected by a serum creatine of 191 μmol/L and estimated glomerular filtration rate of 23 mL/min/1.73 m(2) at 5 years on follow-up.
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
authors.forename: Quaid
authors.initials: Q
authors.lastname: Nadri
authors.affiliation: Department of Medicine, Section of Nephrology, King Faisal Specialist Hospital and Research Center, Riyadh, Ar-Riyadh, Saudi Arabia.
authors.forename: Mohammed Mahdi
authors.identifier: http://orcid.org/0000-0002-3158-8316
authors.initials: MM
authors.lastname: Althaf
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D009853:Omeprazole / Q000009:adverse effects*; D011241:Prednisone / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000009:adverse effects*; D011899:Ranitidine / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D000893:Anti-Inflammatory Agents; D054328:Proton Pump Inhibitors; D011899:Ranitidine; D009853:Omeprazole; D011241:Prednisone