title: Drug transporters in the nasal epithelium: an overview of strategies in targeted drug delivery.
abstract: In this article, we discussed the expression of some ABC (e.g., P-glycoprortein, MRP and CFTR) and SLC (e.g., POT, DAT, OAT, OATP, OCT, EAAT2/GLT1 and GLUT) amino acid, metal and nucleoside transporters in the nasal mucosa. The localization and therapeutic targeting of these transporters are explored in detail. The wide array of transporters discovered so far in the nasal mucosa implies that a plethora of compounds can be delivered by targeting these transporters. The article concludes with a discussion of the potential challenges and delivery options for transporter-mediated drug targeting via the nasal route.
authors.affiliation: Biopharmaceutics & Drug Delivery Lab, College of Pharmacy, 5968 College Street, PO Box 15000, Halifax, NS B3H 4R2, Canada.
authors.forename: Utkarshini
authors.initials: U
authors.lastname: Anand
authors.forename: Ankit
authors.initials: A
authors.lastname: Parikh
authors.forename: Malachy C
authors.initials: MC
authors.lastname: Ugwu
authors.forename: Remigius U
authors.initials: RU
authors.lastname: Agu
mesh_terms: D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009297:Nasal Mucosa / Q000378:metabolism*
chemical_list: D002352:Carrier Proteins; D026901:Membrane Transport Proteins