title: Anti-Müllerian hormone as a marker of premature ovarian aging in autoimmune thyroid disease.
abstract: There is an increased incidence of autoimmune thyroid disease (AITD) in women with infertility. We hypothesized that serum anti-Müllerian hormone (AMH) levels will be lower in premenopausal women with AITD than controls. We evaluated ovarian reserve in women with AITD (n = 85) and healthy controls (n = 80), all <40 years old. Detailed data on reproductive history were obtained. Gonadotrophins, steroids, AMH, and inhibin B levels were measured during the follicular phase. The number of pregnancies as well as live births was lower in women with AITD (p < 0.01). No difference was observed in terms of FSH, estradiol, and inhibin B. AMH levels were lower in AITD women than in controls (1.16 + 0.17 versus 1.28 + 0.25 ng/ml, mean + SD, p = 0.001). According to the multiple regression analysis, even after age adjustment, AITD was significantly and independently affected AMH levels (t = 2.674, p = 0.008). Women with AITD seem to have a diminished ovarian follicular reserve and measurement of serum AMH level has the potential to be used to predict this comorbidity.
authors.affiliation: Department of Endocrinology and Metabolism and.
authors.forename: Fatma
authors.initials: F
authors.lastname: Saglam
authors.forename: Eda Demir
authors.initials: ED
authors.lastname: Onal
authors.forename: Reyhan
authors.initials: R
authors.lastname: Ersoy
authors.forename: Cemile
authors.initials: C
authors.lastname: Koca
authors.forename: Merve
authors.initials: M
authors.lastname: Ergin
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
authors.forename: Bekir
authors.initials: B
authors.lastname: Cakir
mesh_terms: D000328:Adult; D000375:Aging / Q000097:blood; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000150:complications; D007265:Inhibins / Q000097:blood; D065851:Ovarian Reserve; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000097:blood*; D013967:Thyroiditis, Autoimmune / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers; C422364:inhibin B; D004958:Estradiol; D007265:Inhibins; D054304:Anti-Mullerian Hormone
keywords: Folliculogenesis; infertilitiy; ovary; thyroid