title: Estimation of serum superoxide dismutase and serum malondialdehyde in oral submucous fibrosis: a clinical and biochemical study.
abstract: BACKGROUND
  To estimate the level of lipid peroxidation product (MDA) and the activities of antioxidative enzymes superoxide dismutase (SOD) and the correlation of these parameters in Oral Submucous fibrosis (OSF).
  
  
  OBJECTIVE
  Estimation of MDA and SOD levels in OSF patients and controls.
  
  
  METHODS
  Patients above 15 years of age, who were diagnosed as OSF based upon thorough history, clinical examination and histopathological examination without any underlying systemic diseases, were included in the present study. Equal number of healthy subjects without any deleterious habits and without any clinically obvious oral lesions or systemic diseases were selected as the control group.
  
  
  METHODS
  The estimation of MDA in serum was done by thiobarbituric acid reactive species method. SOD was assayed by inhibition and autoxidation of adrenaline method.
  
  
  METHODS
  The data were analyzed with Student's t-test.
  
  
  RESULTS
  Comparison of MDA, SOD among the OSF group and control group showed statistically significant increased levels of malondialdehyde and decreased levels of superoxide dismutase among the OSF groups. Significant changes were not seen in MDA and SOD levels between the different grades of OSF.
  
  
  CONCLUSIONS
  From the present study, estimation of lipid peroxidation like MDA was done, which showed increased levels in the OSF group compared to the control group and antioxidant enzyme levels like SOD showed decreased levels in the OSF group compared to the control group. These can be considered as a subject of interest for their possible role in many of the precancerous and cancerous conditions.
authors.affiliation: Department of Oral Medicine and Radiology, Kamineni Institute of Dental Sciences, Narketpally, Andhra Pradesh, India.
authors.forename: M L
authors.initials: ML
authors.lastname: Avinash Tejasvi
authors.forename: Balaji Babu
authors.initials: BB
authors.lastname: Bangi
authors.forename: P
authors.initials: P
authors.lastname: Geetha
authors.forename: C K
authors.initials: CK
authors.lastname: Anulekha Avinash
authors.forename: B
authors.initials: B
authors.lastname: Chittaranjan
authors.forename: Harsha
authors.initials: H
authors.lastname: Bhayya
authors.forename: Pavani
authors.initials: P
authors.lastname: Donempudi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D009914:Oral Submucous Fibrosis / Q000097:blood* / Q000473:pathology; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood*; D055815:Young Adult
chemical_list: D008315:Malondialdehyde; D013482:Superoxide Dismutase