title: Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis.
abstract: OBJECTIVE
  Patients with obstructive sleep apnea (OSA) frequently exhibit higher rates of dyslipidemia, a risk factor for cardiovascular and cerebrovascular disorders. Treatment for OSA by CPAP may improve cholesterol metabolism. This meta-regression analysis (MA) estimates the effect of CPAP treatment on dyslipidemia.
  
  
  METHODS
  PubMed and Cochrane libraries were searched by utilizing different combinations of keywords: CPAP, obstructive sleep apnea, serum lipids, dyslipidemia, cholesterol, total cholesterol (TC), low density lipoprotein, LDL, high density lipoprotein, HDL, triglyceride, and TG. Inclusion criteria were: (1) English articles and (2) studies with an adult population with the diagnosis of OSA who were treated with CPAP. The OSA group must have cholesterol profile including TC, LDLc, HDLc, and TG, without and with CPAP treatment. Fifty-four studies were reviewed, while 29 studies pooled for MA.
  
  
  RESULTS
  Thirty-four datasets from 29 studies with 1,958 subjects pooled. Treatment duration range was from 2 days to 1 year. TC standardized mean differences (SMD) ranged from -41.5 to -0.077, pooled mean difference (PMD) was -5.660 (LL -6.715 to UL -4.606, p < 0.001). SMD in LDL ranged from -3.7 to 0; PMD was -0.488 (LL -0.715 to UL -0.261, p < 0.001). HDL SMD ranged from -0.498 to 1.94. The PMD was 0.207 (LL 0.05 to UL 0.364, p < 0.01). TG SMD ranged from -9.327 to 1.98; PMD was -0.054 (LL -0.124 to UL 0.016, p < 0.129).
  
  
  CONCLUSIONS
  CPAP treatment for OSA seems to improve dyslipidemia (decrease in total cholesterol and LDL, and increase in HDL). It does not appear to affect TG levels.
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Rashid
authors.initials: R
authors.lastname: Nadeem
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Singh
authors.affiliation: Rematul lil Alameen Institute of Cardiology, Lahore, Pakistan.
authors.forename: Mahwish
authors.initials: M
authors.lastname: Nida
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Sarah
authors.initials: S
authors.lastname: Kwon
authors.affiliation: McMaster University, Hamilton, Canada.
authors.forename: Hassan
authors.initials: H
authors.lastname: Sajid
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Julie
authors.initials: J
authors.lastname: Witkowski
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pahomov
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Kruti
authors.initials: K
authors.lastname: Shah
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: William
authors.initials: W
authors.lastname: Park
authors.affiliation: Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Dan
authors.initials: D
authors.lastname: Champeau
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D045422:Continuous Positive Airway Pressure; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000097:blood*; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol
keywords: CPAP; cholesterol; dyslipidemia; obstructive sleep apnea; sleep disordered breathing