title: Single-step assembly of polymer-lipid hybrid nanoparticles for mitomycin C delivery.
abstract: Mitomycin C is one of the most effective chemotherapeutic agents for a wide spectrum of cancers, but its clinical use is still hindered by the mitomycin C (MMC) delivery systems. In this study, the MMC-loaded polymer-lipid hybrid nanoparticles (NPs) were prepared by a single-step assembly (ACS Nano 2012, 6:4955 to 4965) of MMC-soybean phosphatidyhlcholine (SPC) complex (Mol. Pharmaceutics 2013, 10:90 to 101) and biodegradable polylactic acid (PLA) polymers for intravenous MMC delivery. The advantage of the MMC-SPC complex on the polymer-lipid hybrid NPs was that MMC-SPC was used as a structural element to offer the integrity of the hybrid NPs, served as a drug preparation to increase the effectiveness and safety and control the release of MMC, and acted as an emulsifier to facilitate and stabilize the formation. Compared to the PLA NPs/MMC, the PLA NPs/MMC-SPC showed a significant accumulation of MMC in the nuclei as the action site of MMC. The PLA NPs/MMC-SPC also exhibited a significantly higher anticancer effect compared to the PLA NPs/MMC or free MMC injection in vitro and in vivo. These results suggested that the MMC-loaded polymer-lipid hybrid NPs might be useful and efficient drug delivery systems for widening the therapeutic window of MMC and bringing the clinical use of MMC one step closer to reality.
authors.affiliation: The Affiliated Southeast Hospital of Xiamen University, Xiamen University, Zhangzhou 363000, China.
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China ; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pharmacy, School of Pharmaceutical Science, Xiamen University, Xiamen 361005, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Jia
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Xiangrui
authors.initials: X
authors.lastname: Yang
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Jinyan
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China ; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Shichao
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Zhenqing
authors.initials: Z
authors.lastname: Hou
authors.affiliation: The First Affiliated Hospital of Xiamen University, Xiamen 361003, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Xie
keywords: Cancer chemoprevention; Controlled release; Drug delivery systems; Phospholipids; Self-assembly