title: Copper-catalyzed reductive cross-coupling of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides.
abstract: A copper-catalyzed reductive cross-coupling reaction of nonactivated alkyl tosylates and mesylates with alkyl and aryl bromides was developed. It provides a practical method for efficient and cost-effective construction of aryl-alkyl and alkyl-alkyl CC bonds with stereocontrol from readily available substrates. When used in an intramolecular fashion, the reaction enables convenient access to various substituted carbo- or heterocycles, such as 2,3-dihydrobenzofuran and benzochromene derivatives.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026 (P. R. China); State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 730000 Lanzhou (P. R. China); Department of Chemistry, Tsinghua University, Beijing 100084 (P. R. China).
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Liu
authors.forename: Chu-Ting
authors.initials: CT
authors.lastname: Yang
authors.forename: Xiao-Yu
authors.initials: XY
authors.lastname: Lu
authors.forename: Zhen-Qi
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Mian
authors.initials: M
authors.lastname: Cui
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
keywords: CC bond formation; catalysis; copper; cross-coupling; cyclization