title: Optimisation of [11C]Raclopride production using a Synthra GPextent system.
abstract: The dopamine D2 receptor radiotracer [(11)C]Raclopride is used extensively in clinical and preclinical imaging. Currently, a wide range of methods to produce [(11)C]Raclopride have been developed using traditional vessel reactions as well as cartridge or captive solvent. This work reports the optimisation of the production of [(11)C]Raclopride using a Synthra GPextent, comparing various methods. With optimised conditions, we were able to obtain 4±2% (ndc) yield of [(11)C]Raclopride (100 GBq [(11)C]CO2, n = 42) in 25 min. The radiochemical purity was >95% with specific activities of 135±41 MBq/nmol at end of synthesis.
authors.forename: Gary
authors.initials: G
authors.lastname: Perkins
authors.forename: Rajeev
authors.initials: R
authors.lastname: Sheth
authors.forename: Ivan
authors.initials: I
authors.lastname: Greguric
authors.affiliation: Australian Nuclear Science and Technology Organisation Camperdown, P.O. Box M34 Camperdown, Australia 2050. gary.perkins@ansto.gov.au.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pascali
mesh_terms: D002250:Carbon Radioisotopes; D018491:Dopamine Agonists / Q000494:pharmacology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020891:Raclopride / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D017448:Receptors, Dopamine D2 / Q000187:drug effects*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D018491:Dopamine Agonists; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; D020891:Raclopride