title: Natural antibody - Biochemistry and functions.
abstract: Natural antibodies have been common knowledge in the scientific community for more than half a century. Initially disregarded, their functions have garnered a newfound interest recently. Natural antibodies are usually polyreactive IgM antibodies and are implicated in numerous physiologic and pathologic processes. Current research demonstrates they play a role in adaptive and innate immune responses, autoimmunity, and apoptosis. Evidence exists that they are involved in the modulation of neurodegenerative disorders and malignancy. Furthermore, natural antibodies have been implicated in ischemia reperfusion injury and atherosclerosis. As such the study of natural antibodies may provide new insight into normal physiologic processes whilst concurrently paving the road for a wide-range of possible therapeutic options.
authors.affiliation: Department of Anesthesiology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203.
authors.forename: Ali Seyar
authors.initials: AS
authors.lastname: Rahyab
authors.affiliation: Department of Anesthesiology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203.
authors.forename: Amit
authors.initials: A
authors.lastname: Alam
authors.affiliation: CUNY Brooklyn College, Brooklyn, NY 11210.
authors.forename: Aricka
authors.initials: A
authors.lastname: Kapoor
authors.affiliation: Department of Anesthesiology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203 ; Department of Cell Biology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhang
keywords: Complement; Function; Natural antibody; Pathobiology; Physiology; Structure