title: Short communication: Fc gamma receptors IIa and IIIa genetic polymorphisms do not predict HIV-1 disease progression in Kenyan women.
abstract: Genetic polymorphisms of the Fc gamma receptors (FcγR) IIa and IIIa have been implicated in the rate of HIV-1 disease progression, but results are inconsistent. We aimed to determine the association between these polymorphisms and disease progression in a cohort of HIV-1 seroconverters from Mombasa, Kenya. Neither FcγRIIa nor FcγRIIIa genotypes were predictive of set point viral load, viral load increase, CD4 decline, or HIV-1 disease progression (time to CD4 count <200 cells/mm(3), death, or treatment initiation). Our results suggest that FcγR polymorphisms might not be an important indicator of viral control and disease progression in this population.
authors.affiliation: 1 Division of Human Biology, Fred Hutchinson Cancer Research Center , Seattle, Washington.
authors.forename: Julie F
authors.initials: JF
authors.lastname: Weis
authors.forename: R Scott
authors.initials: RS
authors.lastname: McClelland
authors.forename: Walter
authors.initials: W
authors.lastname: Jaoko
authors.forename: Kishor N
authors.initials: KN
authors.lastname: Mandaliya
authors.forename: Julie
authors.initials: J
authors.lastname: Overbaugh
authors.forename: Susan M
authors.initials: SM
authors.lastname: Graham
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007630:Kenya; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D017452:Receptors, IgG / Q000235:genetics*; D019562:Viral Load
chemical_list: C496124:FCGR3A protein, human; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG