title: Surgical and interventional management of complications caused by acute pancreatitis.
abstract: Acute pancreatitis is one of the most common gastrointestinal disorders worldwide. It requires acute hospitalization, with a reported annual incidence of 13 to 45 cases per 100,000 persons. In severe cases there is persistent organ failure and a mortality rate of 15% to 30%, whereas mortality of mild pancreatitis is only 0% to 1%. Treatment principles of necrotizing pancreatitis and the role of surgery are still controversial. Despite surgery being effective for infected pancreatic necrosis, it carries the risk of long-term endocrine and exocrine deficiency and a morbidity and mortality rate of between 10% to 40%. Considering high morbidity and mortality rates of operative necrosectomy, minimally invasive strategies are being explored by gastrointestinal surgeons, radiologists, and gastroenterologists. Since 1999, several other minimally invasive surgical, endoscopic, and radiologic approaches to drain and debride pancreatic necrosis have been described. In patients who do not improve after technically adequate drainage, necrosectomy should be performed. When minimal invasive management is unsuccessful or necrosis has spread to locations not accessible by endoscopy, open abdominal surgery is recommended. Additionally, surgery is recognized as a major determinant of outcomes for acute pancreatitis, and there is general agreement that patients should undergo surgery in the late phase of the disease. It is important to consider multidisciplinary management, considering the clinical situation and the comorbidity of the patient, as well as the surgeons experience.
authors.affiliation: Feza Y Karakayali, Baskent University, Faculty of Medicine, Department of General Surgery, Ankara 06490, Turkey.
authors.forename: Feza Y
authors.initials: FY
authors.lastname: Karakayali
mesh_terms: D004322:Drainage / Q000379:methods; D016145:Endoscopy, Digestive System / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects / Q000401:mortality; D010180:Pancreatectomy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D012720:Severity of Illness Index; D016896:Treatment Outcome
keywords: Complications; Endoscopy; Laparoscopy; Necrosectomy; Percutaneous drainage; Severe acute pancreatitis