title: Cytotoxic activities of some benzothiazole-piperazine derivatives.
abstract: Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI50 values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Compound 1d is highly cytotoxic against all tested cancer cell lines. Further investigation of compound 1d by Hoechst Staining and Fluorescence-Activated Cell Sorting Analysis (FACS) revealed that this compound causes apoptosis by cell cycle arrest at subG1 phase.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Yeditepe University , Kayisdagi, Istanbul , Turkey and.
authors.forename: Enise Ece
authors.initials: EE
authors.lastname: Gurdal
authors.forename: Irem
authors.initials: I
authors.lastname: Durmaz
authors.forename: Rengul
authors.initials: R
authors.lastname: Cetin-Atalay
authors.forename: Mine
authors.initials: M
authors.lastname: Yarim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D052160:Benzothiazoles; D010879:Piperazines
keywords: Anticancer; benzothiazole; cytotoxicity; piperazine; sulphorodamine B