title: Early critical care course in children after liver transplant.
abstract: Objective. To review the critical care course of children receiving orthotopic liver transplantation (OLT). Methods. A retrospective chart review of patients admitted to the pediatric critical care following OLT performed in our center between 1988 and 2011. Results. A total of 149 transplants in 145 patients with a median age of 2.7 (IQR 0.9-7) years were analyzed. Mortality in the first 28 days was 8%. The median length of stay (LOS) was 7 (4.0-12.0) days. The median length of mechanical ventilation (MV) was 3 (1.0-6.2) days. Open abdomen, age, and oxygenation index on the 2nd day predicted LOS. Open abdomen, age, amount of blood transfused during surgery, and PRISM III predicted length of MV. 28% of patients had infection and 24% developed acute rejection. In recent group (2000-2011) OLT was performed in younger patients; the risk of infection and acute rejection was reduced and patients required longer LOS and MV compared with old group (1988-1999). Conclusion. The postoperative course of children after OLT is associated with multiple complications. In recent years OLT was performed in younger children; living donors were more common; the rate of postoperative infection and suspected rejection was reduced significantly; however patients required longer MV and LOS in the PCCU.
authors.affiliation: Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
authors.forename: Vinay
authors.identifier: 0000-0002-7274-7942
authors.initials: V
authors.lastname: Kukreti
authors.affiliation: Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
authors.forename: Hani
authors.initials: H
authors.lastname: Daoud
authors.affiliation: Division of Respiratory Medicine, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON, Canada M5G 1X8.
authors.forename: Sundeep S
authors.initials: SS
authors.lastname: Bola
authors.affiliation: Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
authors.forename: Ram N
authors.initials: RN
authors.lastname: Singh
authors.affiliation: Department of Pediatrics, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
authors.forename: Paul
authors.initials: P
authors.lastname: Atkison
authors.affiliation: Department of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, University of Western Ontario, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9 ; Children's Health Research Institute, 800 Commissioners Road East, P.O. Box 5010, London, ON, Canada N6A 5W9.
authors.forename: Alik
authors.initials: A
authors.lastname: Kornecki