title: Whole-body vibration training effect on physical performance and obesity in mice.
abstract: The purpose of this study was to verify the beneficial effects of whole-body vibration (WBV) training on exercise performance, physical fatigue and obesity in mice with obesity induced by a high-fat diet (HFD). Male C57BL/6 mice were randomly divided into two groups: normal group (n=6), fed standard diet (control), and experimental group (n=18), fed a HFD. After 4-week induction, followed by 6-week WBV of 5 days per week, the 18 obese mice were divided into 3 groups (n=6 per group): HFD with sedentary control (HFD), HFD with WBV at relatively low-intensity (5.6 Hz, 0.13 g) (HFD+VL) or high-intensity (13 Hz, 0.68 g) (HFD+VH). A trend analysis revealed that WBV increased the grip strength in mice. WBV also dose-dependently decreased serum lactate, ammonia and CK levels and increased glucose level after the swimming test. WBV slightly decreased final body weight and dose-dependently decreased weights of epididymal, retroperitoneal and perirenal fat pads and fasting serum levels of alanine aminotransferase, CK, glucose, total cholesterol and triacylglycerol. Therefore, WBV could improve exercise performance and fatigue and prevent fat accumulation and obesity-associated biochemical alterations in obese mice. It may be an effective intervention for health promotion and prevention of HFD-induced obesity.
authors.affiliation: 1. Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Chi-Chang
authors.initials: CC
authors.lastname: Huang
authors.affiliation: 1. Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Tzu-Ling
authors.initials: TL
authors.lastname: Tseng
authors.affiliation: 2. Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 33301, Taiwan.
authors.forename: Wen-Ching
authors.initials: WC
authors.lastname: Huang
authors.affiliation: 3. Molecular Imaging Center and Department of Nuclear Medicine, Chang Gung Memorial Hospital, Taoyuan 33305, Taiwan.
authors.forename: Yi-Hsiu
authors.initials: YH
authors.lastname: Chung
authors.affiliation: 4. National Laboratory Animal Center, National Applied Research Laboratories, Taipei 11529, Taiwan.
authors.forename: Hsiao-Li
authors.initials: HL
authors.lastname: Chuang
authors.affiliation: 5. Department of Forestry, National Chung Hsing University, Taichung 40227, Taiwan.
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Wu
mesh_terms: D050154:Adiposity; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001835:Body Weight; D059305:Diet, High-Fat / Q000009:adverse effects; D004326:Drinking; D002149:Energy Intake; D005221:Fatigue / Q000503:physiopathology; D018737:Hand Strength; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D010805:Physical Conditioning, Animal / Q000379:methods*; D014732:Vibration / Q000627:therapeutic use*
chemical_list: D015415:Biomarkers
keywords: exercise performance; fatigue; high fat diet; obesity; vibration training