title: Efficient synthesis of the tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain.
abstract: The tetrasaccharide repeating unit of the O-antigen of Escherichia coli O174 strain was synthesized applying sequential glycosylations of suitably functionalized monosaccharide intermediates. Activation of glycosyl trichloroacetimidate derivatives using nitrosyl tetrafluoroborate (NOBF4) has been used during the synthesis. The glycosylation steps were high yielding with satisfactory stereo outcome.
authors.affiliation: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India.
authors.forename: Ishani
authors.initials: I
authors.lastname: Bhaumik
authors.affiliation: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India.
authors.forename: Tamashree
authors.initials: T
authors.lastname: Ghosh
authors.affiliation: Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII-M, Kolkata 700054, India. Electronic address: akmisra69@gmail.com.
authors.forename: Anup Kumar
authors.initials: AK
authors.lastname: Misra
mesh_terms: D002240:Carbohydrate Sequence; D004926:Escherichia coli / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019081:O Antigens / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019081:O Antigens; D009844:Oligosaccharides
keywords: Escherichia coli; Glycosylation; Nitrosyl tetrafluoroborate; Tetrasaccharide; Thioglycoside; Trichloroacetimidate