title: Progression of limb apraxia in corticobasal syndrome: neuropychological and functional neuroimaging report of a case series.
abstract: The current study described the progression of limb apraxia in seven corticobasal syndrome patients through a comprehensive battery, including both gesture production tasks and conceptual tool/action knowledge tasks. The examination of the behavioral and neuroimaging (SPECT) data revealed two patient subgroups. One group consisted of patients with preserved conceptual tool/action knowledge, relatively mild gesture production and neuropsychological deficits with few significantly hypoperfused regions of interest. The other group consisted of those whose conceptual tool/action knowledge and general cognition eventually deteriorated and who were quite severely affected in their gesture production performance. These patients were characterized by bilateral hypoperfusion in parietal regions and in one case bilateral anterior cingulate regions.
authors.affiliation: a Rotman Research Institute , Baycrest/University of Toronto , Toronto , ON , Canada.
authors.forename: Vessela
authors.initials: V
authors.lastname: Stamenova
authors.forename: Eric A
authors.initials: EA
authors.lastname: Roy
authors.forename: Gregory
authors.initials: G
authors.lastname: Szilagyi
authors.forename: Kie
authors.initials: K
authors.lastname: Honjo
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Black
authors.forename: Mario
authors.initials: M
authors.lastname: Masellis
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020240:Apraxia, Ideomotor / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000523:psychology*; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005868:Gestures; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D015899:Tomography, Emission-Computed, Single-Photon
keywords: SPECT; corticobasal syndrome; imitation; limb apraxia; pantomime