title: NK/T cell lymphoma involving mediastinum: report of a case and review of literature.
abstract: Extranodal natural killer (NK)/T-cell lymphoma is a very aggressive malignant neoplasia with a poor prognosis. Herein we reported a case of NK/T cell lymphoma involving mediastinum. It was a 28-year-old Chinese male patient. The tumor cells were medium-sized, had irregularly folded nuclei, and inconspicuous or small nucleoli with coagulative necrosis. The tumor cells were positive for CD3ε, TIA-1, but negative for CD56. In situ hybridization revealed that tumor cells also expressed Epstein-Barr virus encoded RNA. To our knowledge, this is the first case of NK/T cell lymphoma involving mediastinum.
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiology, Xiangya Hospital, Central South University Changsha, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Liao
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
authors.forename: Bao-An
authors.initials: BA
authors.lastname: Liu
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
authors.forename: Ji-Fang
authors.initials: JF
authors.lastname: Wen
authors.affiliation: Department of Pathology, Xiangya Hospital, Central South University Changsha, China ; Department of Pathology, Xiangya Medical School, Central South University Changsha, China.
authors.forename: Zhong-Liang
authors.initials: ZL
authors.lastname: Hu
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D004822:Epididymis / Q000276:immunology / Q000473:pathology* / Q000821:virology; D017809:Fatal Outcome; D005834:Genital Neoplasms, Male / Q000276:immunology / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D054391:Lymphoma, Extranodal NK-T-Cell / Q000276:immunology / Q000473:pathology* / Q000821:virology; D008297:Male; D008479:Mediastinal Neoplasms / Q000276:immunology / Q000473:pathology* / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D012367:RNA, Viral
keywords: Epstein-Barr virus; NK/T cell lymphoma; mediastinum