title: MicroRNA expression profiles in the management of papillary thyroid cancer.
abstract: Papillary thyroid cancer (PTC) is the major contributor to the dramatically increasing incidence of thyroid cancer. Low-risk PTC shows the most rapid rate of increase because of changing trends in neck imaging and the use of fine needle aspiration to investigate thyroid nodules. The need for a paradigm shift in the management of these patients, to provide personalized treatment and surveillance plans, has led to the focus on molecular biomarker research. MicroRNAs (miRNAs) compose a class of molecules with promising applications for every stage of PTC management, including diagnosis, prognosis, treatment, and surveillance. Although most of the miRNA studies are currently preclinical, given the rapid progress of scientific discovery, clinical trials will not be far away. Thyroid clinicians will be expected to have good insights into the current status of PTC-related molecular translational research. This article focuses on the potential roles of miRNA in PTC management in the context of contemporary recommended clinical practice.
authors.affiliation: Department of Surgery, Monash University, Melbourne, Victoria, Australia; Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia; Kolling Institute of Medical Research, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia; Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia Lee.JamesC@gmail.com.
authors.forename: James C
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Department of Surgery, Monash University, Melbourne, Victoria, Australia; Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia; Kolling Institute of Medical Research, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia; Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: Justin S
authors.initials: JS
authors.lastname: Gundara
authors.affiliation: Department of Surgery, Monash University, Melbourne, Victoria, Australia; Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia; Kolling Institute of Medical Research, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia; Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: Anthony
authors.initials: A
authors.lastname: Glover
authors.affiliation: Department of Surgery, Monash University, Melbourne, Victoria, Australia; Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia; Kolling Institute of Medical Research, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia; Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Serpell
authors.affiliation: Department of Surgery, Monash University, Melbourne, Victoria, Australia; Endocrine Surgery Unit, Alfred Hospital, Melbourne, Victoria, Australia; Kolling Institute of Medical Research, Sydney, New South Wales, Australia; University of Sydney, Sydney, New South Wales, Australia; Endocrine Surgical Unit, Royal North Shore Hospital, Sydney, New South Wales, Australia.
authors.forename: Stan B
authors.initials: SB
authors.lastname: Sidhu
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002277:Carcinoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D002291:Carcinoma, Papillary; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs; D011379:Prognosis; D012333:RNA, Messenger; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D057170:Translational Research, Biomedical
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs; D012333:RNA, Messenger
keywords: Biological markers; Papillary carcinoma; Prognosis; Translational medical research; miRNAs