title: Impact of sleep-disordered breathing on metabolic dysfunctions in patients with polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is the most common endocrinological disorder among women in the reproductive age group. These women are prone to develop sleep-disordered breathing (SDB) and metabolic disorders. SDB is also associated with metabolic dysfunctions. We hypothesized that SDB is an independent risk factor contributing to metabolic dysfunctions in women with PCOS.
  
  
  METHODS
  Prospective cross-sectional study in which 50 women with PCOS and not on any treatment were selected. They were divided into two groups: Group 1 - PCOS with SDB and Group 2 - PCOS without SDB.
  
  
  RESULTS
  Thirty-three (66%) women with PCOS had SDB. Women in Group 1 had significantly higher systolic blood pressure (SBP) (P = 0.002); diastolic blood pressure (DBP) (P = 0.044); fasting blood sugar (P = 0.006), triglyceride levels (P = 0.014) and mean Ferriman-Gallwey score (P = 0.028). The HDL was significantly lower in group 1 (P = 0.006). In group 1, 42.4% of women had metabolic syndrome (P < 0.001). Excessive daytime sleepiness (EDS) was significantly higher in Group 1 (P = 0.04). Respiratory distress index significantly correlated positively with waist circumference (r = 0.551, P < 0.001), SBP (r = 0.455, P = 0.001), DBP (r = 0.387, P = 0.006), FBS (r = 0.524, P = 0.000), homeostatic model assessment (r = 0.512, P = 0.000), triglycerides (r = 0.384, P = 0.006), free testosterone (r = 0.390, P = 0.005), and negatively with HDL (r = -0.555, P < 0.001).
  
  
  CONCLUSIONS
  Women with PCOS and SDB had significantly increased metabolic abnormalities as well as more severe hyperandrogenism. Women with PCOS who have metabolic abnormalities or severe hyperandrogenism should undergo an overnight PSG.
authors.affiliation: Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
authors.forename: Bidisha
authors.initials: B
authors.lastname: Chatterjee
authors.affiliation: Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Suri
authors.affiliation: Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India. Electronic address: docjcsuri@gmail.com.
authors.forename: Jagdish Chander
authors.initials: JC
authors.lastname: Suri
authors.affiliation: Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
authors.forename: Pratima
authors.initials: P
authors.lastname: Mittal
authors.affiliation: Vardhaman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
authors.forename: Tulsi
authors.initials: T
authors.lastname: Adhikari
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000209:etiology; D008659:Metabolic Diseases / Q000209:etiology*; D024821:Metabolic Syndrome / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000378:metabolism; D017286:Polysomnography; D011446:Prospective Studies; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D014280:Triglycerides
keywords: Hyperandrogenism; Insulin resistance; Metabolic dysfunction; Metabolic syndrome; Polycystic ovary syndrome (PCOS); Sleep-disordered breathing (SDB)