title: Lobomycosis: epidemiology, clinical presentation, and management options.
abstract: Lobomycosis is a subcutaneous mycosis of chronic evolution caused by the Lacazia loboi fungus. Its distribution is almost exclusive in the Americas, and it has a particularly high prevalence in the Amazon basin. Cases of lobomycosis have been reported only in dolphins and humans. Its prevalence is higher among men who are active in the forest, such as rubber tappers, bushmen, miners, and Indian men. It is recognized that the traumatic implantation of the fungus on the skin is the route by which humans acquire this infection. The lesions affect mainly exposed areas such as the auricles and upper and lower limbs and are typically presented as keloid-like lesions. Currently, surgical removal is the therapeutic procedure of choice in initial cases. Despite the existing data and studies to date, the active immune mechanisms in this infection and its involvement in the control or development of lacaziosis have not been fully clarified. In recent years, little progress has been made in the appraisal of the epidemiologic aspects of the disease. So far, we have neither a population-based study nor any evaluation directed to the forest workers.
authors.affiliation: Department of Dermatology, Tropical Medicine Foundation Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Valeska Albuquerque
authors.initials: VA
authors.lastname: Francesconi
authors.affiliation: Amazon Federal University, Manaus, Amazonas, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Klein
authors.affiliation: Amazon Federal University, Manaus, Amazonas, Brazil.
authors.forename: Ana Paula Botelho Gualda
authors.initials: AP
authors.lastname: Santos
authors.affiliation: Department of Immunogenetics, Tropical Medicine Foundation Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Rajendranath
authors.initials: R
authors.lastname: Ramasawmy
authors.affiliation: Department of Dermatology, Tropical Medicine Foundation Heitor Vieira Dourado, Manaus, Amazonas, Brazil.
authors.forename: Fábio
authors.initials: F
authors.lastname: Francesconi
keywords: Lacazia loboi; infection; lacaziosis; lobomycosis; mycosis