title: The effect of folic acid supplementation with ferrous sulfate on the linear and ponderal growth of children aged 6-24 months: a randomized controlled trial.
abstract: OBJECTIVE
  Studies evaluating the effect of folic acid supplementation, either alone or in combination with iron, on the linear and ponderal growth of children are practically nonexistent. The aim of this study was to assess the effect of folic acid supplementation with ferrous sulfate on both linear growth and weight gain in anemic and nonanemic children attending Municipal Daycare Centers in Goiania, State of Goias, Brazil.
  
  
  METHODS
  A double-blind, randomized, controlled trial was conducted on 188 children aged 6-24 months. The effects of ferrous sulfate and folic acid supplementation were evaluated using the analysis of variance procedure, based on a double factorial model with two factors of fixed effects (folic acid supplementation and ferrous sulfate supplementation), adjusted for initial weight. The level of significance was 0.05.
  
  
  RESULTS
  The children who received folic acid supplementation showed greater weight gain than the monthly average weight gain of those not given the supplement (P=0.026). This effect was independent of the dose of ferrous sulfate (P for interaction=0.693). Folic acid supplementation increased the gain of weight-for-age Z-score when compared with the placebo group (P=0.018), independent of the dose of ferrous sulfate.
  
  
  CONCLUSIONS
  Folic acid had no effect on linear growth. The use of folic acid supplementation increased the monthly average weight gain and the gain in weight-for-age Z-score compared with the placebo group. This effect was independent of the dose of ferrous sulfate.
authors.affiliation: Faculty of Nutrition Federal University of Goias - UFG, Goiânia, Goiás, Brazil.
authors.forename: D A
authors.initials: DA
authors.lastname: Medeiros
authors.affiliation: Faculty of Nutrition Federal University of Goias - UFG, Goiânia, Goiás, Brazil.
authors.forename: M C C M
authors.initials: MC
authors.lastname: Hadler
authors.affiliation: Faculty of Nutrition Federal University of Goias - UFG, Goiânia, Goiás, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Sugai
authors.affiliation: School of Medicine, Pontifical Catholic University of Goias (PUC - Goiás). Goiânia, Goiás, Brazil.
authors.forename: V M
authors.initials: VM
authors.lastname: Torres
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy / Q000517:prevention & control*; D001827:Body Height / Q000187:drug effects; D002675:Child, Preschool; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005296:Ferrous Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D005492:Folic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D007501:Iron / Q000494:pharmacology / Q000627:therapeutic use*; D000090463:Iron Deficiencies; D008297:Male; D013851:Thinness / Q000517:prevention & control; D014803:Vitamin B Complex / Q000494:pharmacology* / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects
chemical_list: D005296:Ferrous Compounds; D014803:Vitamin B Complex; C020748:ferrous sulfate; D005492:Folic Acid; D007501:Iron