title: Biological therapy for ulcerative colitis: an update.
abstract: Of the diverse biological agents used for patients with ulcerative colitis, the anti-tumor necrosis factor-α agents infliximab and adalimumab have been used in large-scale clinical trials and are currently widely used in the treatment of inflammatory bowel disease patients. Recent studies have indicated that golimumab, oral tofacitinib and vedolizumab reportedly achieved good clinical response and remission rates in ulcerative colitis patients. Thus, we believe that the detailed investigation of various studies on clinical trials may provide important information for the selection of appropriate biological agents, and therefore, we have extensively reviewed such trials in the present study.
authors.affiliation: Geom Seog Seo, Department of Gastroenterology, Wonkwang University School of Medicine, Digestive Disease Research Institute, Chonbuk 570-749, South Korea.
authors.forename: Geom Seog
authors.initials: GS
authors.lastname: Seo
authors.affiliation: Geom Seog Seo, Department of Gastroenterology, Wonkwang University School of Medicine, Digestive Disease Research Institute, Chonbuk 570-749, South Korea.
authors.forename: Soo-Cheon
authors.initials: SC
authors.lastname: Chae
mesh_terms: D001688:Biological Products / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy; D012074:Remission Induction; D015398:Signal Transduction / Q000187:drug effects; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001688:Biological Products; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Biological therapy; Clinical trial; Immune dysfunction; Inflammatory bowel disease; Remission; Ulcerative colitis