title: Nobiletin protects dopaminergic neurons in the 1-methyl-4-phenylpyridinium-treated rat model of Parkinson's disease.
abstract: This study investigated the effect of nobiletin, a flavonoid found in citrus fruits, on the degeneration of dopaminergic (DA) neurons in a neurotoxin model of Parkinson's disease (PD). 1-Methyl-4-phenylpyridinium (MPP(+)) was unilaterally injected into the median forebrain bundle of rat brains (to generate a neurotoxin model of PD) with or without daily intraperitoneal injection of nobiletin. Our results showed that nobiletin treatment at 10 mg/kg bw, but not at 1 or 20 mg/kg bw, significantly protected DA neurons in the substantia nigra (SN) of MPP(+)-treated rats. In parallel to the neuroprotection, nobiletin treatment at 10 mg/kg inhibited microglial activation and preserved the expression of the glial cell line-derived neurotrophic factor, which is a therapeutic agent against PD, in the SN. These results suggest that the proper supplementation with nobiletin may protect against the neurodegeneration involved in PD.
authors.affiliation: 1 School of Life Sciences, Kyungpook National University , Daegu, Korea.
authors.forename: Kyoung Hoon
authors.initials: KH
authors.lastname: Jeong
authors.forename: Min-Tae
authors.initials: MT
authors.lastname: Jeon
authors.forename: Heung Deok
authors.initials: HD
authors.lastname: Kim
authors.forename: Un Ju
authors.initials: UJ
authors.lastname: Jung
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Jang
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Chu
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Yang
authors.forename: Il Yoon
authors.initials: IY
authors.lastname: Choi
authors.forename: Myung-Sook
authors.initials: MS
authors.lastname: Choi
authors.forename: Sang Ryong
authors.initials: SR
authors.lastname: Kim
mesh_terms: D015655:1-Methyl-4-phenylpyridinium / Q000633:toxicity*; D000818:Animals; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D047309:Flavones / Q000008:administration & dosage*; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013378:Substantia Nigra
chemical_list: D047309:Flavones; D051100:Glial Cell Line-Derived Neurotrophic Factor; D018696:Neuroprotective Agents; C008661:nobiletin; D015655:1-Methyl-4-phenylpyridinium
keywords: GDNF; MPP+; dopaminergic neuron; microglia; neuroprotection; nobiletin