title: Genetics of sudden cardiac death in the young.
abstract: Sudden cardiac death (SCD) has an enormous impact on those who are left behind, evoking strong feelings of anxiety and incomprehension because such a dramatic event was not anticipated. Moreover, over the last decade a prominent genetic contribution to the pathogenesis of SCD has been unveiled. As many inherited cardiac diseases show an autosomal dominant pattern of inheritance, the risk of carrying the same inherited predisposition is a real concern for the relatives. In this article, we discuss the major causes of primary electrical disorders, cardiomyopathies and thoracic aortic dissection and address issues in genotype-phenotype correlation, personalized management and cardiogenetic counselling.
authors.affiliation: Department of Cardiology, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: J B
authors.initials: JB
authors.lastname: Saenen
authors.affiliation: Department of Cardiology, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: E M
authors.initials: EM
authors.lastname: Van Craenenbroeck
authors.affiliation: Center for Medical Genetics, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: D
authors.initials: D
authors.lastname: Proost
authors.affiliation: Department of Pediatric Cardiology, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Marchau
authors.affiliation: Center for Medical Genetics, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Van Laer
authors.affiliation: Department of Cardiology, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: C J
authors.initials: CJ
authors.lastname: Vrints
authors.affiliation: Center for Medical Genetics, Antwerp University Hospital/University of Antwerp, Antwerp, Belgium.
authors.forename: B L
authors.initials: BL
authors.lastname: Loeys
mesh_terms: D017545:Aortic Aneurysm, Thoracic / Q000235:genetics*; D001145:Arrhythmias, Cardiac / Q000235:genetics*; D009202:Cardiomyopathies / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D016757:Death, Sudden, Cardiac / Q000473:pathology*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans
keywords: cardiogenetics; cardiomyopathy; primary electrical disorder; thoracic aortic aneurysm