title: Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia.
abstract: BACKGROUND
  Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands.
  
  
  OBJECTIVE
  We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands.
  
  
  METHODS
  We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots.
  
  
  RESULTS
  Leptin mRNA levels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia.
  
  
  CONCLUSIONS
  Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.
authors.affiliation: Specialized Center of Secondary Hypertension (C.L., L.P., L.Z., C.M.), Department of Internal Medicine and Medical Specialties (C.L., L.P., L.Z., C.M., G.I.), "Sapienza" University of Rome, Italy; Department of Radiological Sciences (C.R.T.D.G., C.C., A.C.), Oncology and Anatomical Pathology, "Sapienza" University of Rome, Italy; Department of Surgery "Pietro Valdoni" (G.D.T.), "Sapienza" University of Rome, Italy 00161; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine (G.I.), University of Miami, Miller School of Medicine, Miami, Florida 33136.
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
authors.forename: Luigi
authors.initials: L
authors.lastname: Petramala
authors.forename: Cira Rosaria Tiziana
authors.initials: CR
authors.lastname: Di Gioia
authors.forename: Caterina
authors.initials: C
authors.lastname: Chiappetta
authors.forename: Laura
authors.initials: L
authors.lastname: Zinnamosca
authors.forename: Cristiano
authors.initials: C
authors.lastname: Marinelli
authors.forename: Gino
authors.initials: G
authors.lastname: Iannucci
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciardi
authors.forename: Giorgio
authors.initials: G
authors.lastname: De Toma
authors.forename: Gianluca
authors.initials: G
authors.lastname: Iacobellis
mesh_terms: D000236:Adenoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D020738:Leptin / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: D052242:Adiponectin; D020738:Leptin; D012333:RNA, Messenger