title: Cu(II)-mediated C-S/N-S bond formation via C-H activation: access to benzoisothiazolones using elemental sulfur.
abstract: A copper-mediated C-S/N-S bond-forming reaction via C-H activation that uses elemental sulfur has been developed. The addition of TBAI was found to be crucial for the success of this transformation. The method is scalable, shows excellent functional group tolerance, and is compatible with heterocycle substrates, providing efficient and practical access to benzoisothiazolones. The direct diversification of the benzoisothiazolone products into a variety of sulfur-containing compounds is also demonstrated.
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310027, China.
authors.forename: Fa-Jie
authors.initials: FJ
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Liao
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Bing-Feng
authors.initials: BF
authors.lastname: Shi
mesh_terms: D003300:Copper / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D013438:Sulfhydryl Compounds; D013844:Thiazoles; D013455:Sulfur; D003300:Copper