title: Motor Speech Disorders Associated with Primary Progressive Aphasia.
abstract: BACKGROUND
  Primary progressive aphasia (PPA) and conditions that overlap with it can be accompanied by motor speech disorders. Recognition and understanding of motor speech disorders can contribute to a fuller clinical understanding of PPA and its management as well as its localization and underlying pathology.
  
  
  OBJECTIVE
  To review the types of motor speech disorders that may occur with PPA, its primary variants, and its overlap syndromes (progressive supranuclear palsy syndrome, corticobasal syndrome, motor neuron disease), as well as with primary progressive apraxia of speech.
  
  
  RESULTS
  The review should assist clinicians' and researchers' understanding of the relationship between motor speech disorders and PPA and its major variants. It also highlights the importance of recognizing neurodegenerative apraxia of speech as a condition that can occur with little or no evidence of aphasia.
  
  
  CONCLUSIONS
  Motor speech disorders can occur with PPA. Their recognition can contribute to clinical diagnosis and management of PPA and to understanding and predicting the localization and pathology associated with PPA variants and conditions that can overlap with them.
authors.affiliation: Dept. of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, U.S.A.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Duffy
authors.affiliation: Dept. of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, U.S.A.
authors.forename: Edythe A
authors.initials: EA
authors.lastname: Strand
authors.affiliation: Dept. of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, U.S.A.
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
keywords: apraxia of speech; dysarthrias; motor speech disorders; primary progressive aphasia; primary progressive apraxia of speech