title: Effect of Baechu Kimchi Added Ecklonia cava Extracts on High Glucose-induced Oxidative Stress in Human Umbilical Vein Endothelial Cells.
abstract: Endothelial cell dysfunction is considered to be a major cause of vascular complications in diabetes. In the present study, we investigated the protective effect of a baechu kimchi added Ecklonia cava extract (BKE) against high glucose induced oxidative damage in human umbilical vein endothelial cells (HUVECs). Treatment with a high concentration of glucose (30 mM) induced cytotoxicity, whereas treatment with BKE protected HUVECs from high glucose induced damage; by restoring cell viability. In addition, BKE reduced lipid peroxidation, intracellular reactive oxygen species and nitric oxide levels in a dose dependent manner. Treatment with high glucose concentrations also induced the overexpression of inducible nitric oxide synthase, cyclooxygenase-2 and NF-κB proteins in HUVECs, but BKE treatment significantly reduced the overexpression of these proteins. These findings indicate that BKE may be a valuable treatment against high glucose-induced oxidative stress HUVECs.
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
authors.forename: Hyun-Ah
authors.initials: HA
authors.lastname: Lee
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
authors.forename: Yeong-Ok
authors.initials: YO
authors.lastname: Song
authors.affiliation: Food and Safety Research Center, National Fisheries Research & Development Institute, Busan 619-705, Korea.
authors.forename: Mi-Soon
authors.initials: MS
authors.lastname: Jang
authors.affiliation: Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
authors.forename: Ji-Sook
authors.initials: JS
authors.lastname: Han
keywords: Ecklonia cava; baechu kimchi; high glucose; human umbilical vein endothelial cells (HUVECs); oxidative stress