title: Bilateral synchronous high-grade serous carcinoma and clear cell carcinoma in right and left ovaries with immunohistochemical confirmation: an exceptional finding.
abstract: Synchronous epithelial or mixed epithelial and germ cells tumors in the same ovary is a recognized event, however, having two different surface epithelial tumors in contra lateral ovaries is a rare occurrence; prognosis and pathogenesis of which is still not clear. We came across similar finding in a 60-year-old female with different types of surface epithelial neoplasm in right and left ovaries at the same time; both of which were malignant. Clinicoradiologically only the left ovary revealed tumor, right ovary was atrophic. To our surprise, left ovary revealed high grade serous carcinoma and the right ovary displayed clear cell carcinoma. We performed immunohistochemistry to rule out the possibility of clear cell variant of serous papillary carcinoma. On literature search, we found; only single case with synchronous presentation of two different surface epithelial ovarian tumors in the same patient, both of which were benign.
authors.affiliation: Department of Pathology, KGMU, Lucknow, Uttar Pradesh, India.
authors.forename: Agarwal
authors.initials: A
authors.lastname: Preeti
authors.forename: Kumar Arun
authors.initials: KA
authors.lastname: Arunachalam
authors.forename: Yashodhara
authors.initials: Y
authors.lastname: Pradeep
authors.forename: Goel Madhu
authors.initials: GM
authors.lastname: Mati
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D018284:Cystadenocarcinoma, Serous / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D004847:Epithelial Cells / Q000166:cytology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009852:Omentum / Q000601:surgery; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor