title: Characteristics of the runway model of intracranial self-stimulation behavior and comparison with other motivated behaviors.
abstract: Motivation incorporates several psychological aspects that produce reward-related and learning behaviors. Although reward-related behavior is reported to be mediated by the dopaminergic reward pathway, the involvement of dopaminergic systems in motivated behavior has not been fully clarified. Several experimental methodologies for motivational behavior have been reported, but pharmacological characteristics seem to vary among these methodologies. In this review, we attempt to summarize three main concepts:(1) the relationship of dopamine neuron physiology with motivated behavior, (2) the pharmacological characteristics of the runway intracranial self-stimulation model, and (3) the behavioral distinction of disparate motivated behaviors.
authors.affiliation: Department of Pharmacy, Okayama University Hospital, Okayama 700-8558, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Esumi
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Gomita
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Sendo
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology; D015984:Causality; D004298:Dopamine / Q000502:physiology; D059290:Dopaminergic Neurons / Q000502:physiology; D007858:Learning / Q000502:physiology*; D023421:Models, Animal; D008954:Models, Biological; D009042:Motivation / Q000502:physiology*; D051381:Rats; D012201:Reward; D012420:Running / Q000502:physiology* / Q000523:psychology; D012653:Self Stimulation / Q000502:physiology*
chemical_list: D004298:Dopamine