title: Clinical trials of yeast-derived β-(1,3) glucan in children: effects on innate immunity.
abstract: BACKGROUND
  The role of glucan in the stimulation of immune reactions is well established. In our report, we focused on the effects of orally administered glucan on nonspecific immunity of children with chronic respiratory problems.
  
  
  METHODS
  We measured the levels of albumin, lysozyme. C-reactive protein (CRP) and calprotectin in the saliva of 60 children ages 8-12 years and evaluated the effects of 30-day treatment with 100 mg/d oral dose of glucan.
  
  
  RESULTS
  We found a significant increase in the production of lysozyme, CRP and calprotectin in glucan-treated children.
  
  
  CONCLUSIONS
  Short-term oral application of natural immunomodulator β-glucan significantly stimulated mucosal immunity of children with chronic respiratory problems.
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Josef
authors.initials: J
authors.lastname: Richter
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Svozil
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Král
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Lucie
authors.initials: L
authors.lastname: Rajnohová Dobiášová
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Ivana
authors.initials: I
authors.lastname: Stiborová
authors.affiliation: 1 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 2 Sanatorium Edel, Zlaté Hory, Czech Republic ; 3 University of Louisville, Department of Pathology, Louisville, KY, USA.
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
keywords: Glucan; children; lysozyme; mucosal immunity; saliva