title: Nickel-catalyzed reductive methylation of alkyl halides and acid chlorides with methyl p-tosylate.
abstract: Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions.
authors.affiliation: College of Chemistry and Molecular Engineering, Zhengzhou University , 100 Science Road, Zhengzhou 450001, China.
authors.forename: Zhuye
authors.initials: Z
authors.lastname: Liang
authors.forename: Weichao
authors.initials: W
authors.lastname: Xue
authors.forename: Kunhua
authors.initials: K
authors.lastname: Lin
authors.forename: Hegui
authors.initials: H
authors.lastname: Gong
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D001557:Benzenesulfonates / Q000737:chemistry*; D002384:Catalysis; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*
chemical_list: D000473:Alkanes; D001557:Benzenesulfonates; D006843:Hydrocarbons, Chlorinated; D007659:Ketones; C506825:methyl tosylate; D009532:Nickel