title: [Myopathy and rhabdomyolysis after treatment with simvastatin, amlodipine, and roxithromycin].
abstract: This is a case report of a 71-year-old male with known diabetes, hypertension and diabetic nephropaty who over the course of one year developed an unrecognized myopathy due to concomitant treatment with high-dose simvastatin and amlodipin. Due to rhabdomyolysis he was after seven days of treatment with roxithromycin admitted to hospital with loss of the ability to walk. We wish to raise awareness of the potentially severe side effects of simvastatin and to emphasize that these can be limited by increased attention to patients with risk factors and to interactions with other drugs.
authors.affiliation: Neurologisk Afdeling, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. E-mail: saralyngby@gmail.com.
authors.forename: Sara Lyngby
authors.initials: SL
authors.lastname: Skovbølling
authors.forename: Mette
authors.initials: M
authors.lastname: Lindelof
mesh_terms: D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology; D015575:Roxithromycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000959:Antihypertensive Agents; D017311:Amlodipine; D015575:Roxithromycin; D019821:Simvastatin