title: Rational design of cancer-targeted BSA protein nanoparticles as radiosensitizer to overcome cancer radioresistance.
abstract: Radiotherapy displays curative potential for cervical cancer management, but radioresistance occurs during long-term therapy. To overcome this limitation, tumor-targeted nanotechnology has been proposed to enhance the radiosensitivity of solid tumors. Herein, we used biocompatible bovine serum albumin nanoparticles (BSANPs) as carriers of organic selenocompound (PSeD) with folate (FA) as the targeting ligand to fabricate a cancer-targeted nanosystem. The combination of PSeD and BSANPs endowed the nanosystem with higher light absorption and reactive oxygen species (ROS) generation owing to their properties of surface plasmon resonance (SPR) effect, heavy metal effect, high refractive index and nanoparticulate interfacial effect. The combined treatment drastically increased the ROS overproduction, VEGF/VEGFR2 inactivation and inhibition of XRCC-1-mediated repair of DNA damage, thus triggering G2/M phase arrest and apoptosis. Taken together, our findings demonstrate the utility of FA-BSANPs as a promising radiosensitizer to improve cancer radiotherapy.
authors.affiliation: Department of Chemistry, Jinan University , Guangzhou 510632, China.
authors.forename: Yanyu
authors.initials: Y
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Luo
authors.forename: Wenjie
authors.initials: W
authors.lastname: Zheng
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Chen
mesh_terms: D045744:Cell Line, Tumor; D048430:Cell Shape / Q000187:drug effects; D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D011878:Radiotherapy; D017382:Reactive Oxygen Species; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects; D014965:X-Rays
chemical_list: D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D012710:Serum Albumin, Bovine; D005492:Folic Acid
keywords: bovine serum albumin nanoparticles; cancer-targeted nanosystem; folate; radiosensitization; radiotherapy