title: Multicenter study of isavuconazole MIC distributions and epidemiological cutoff values for the Cryptococcus neoformans-Cryptococcus gattii species complex using the CLSI M27-A3 broth microdilution method.
abstract: Epidemiological cutoff values (ECVs) of isavuconazole are not available for Cryptococcus spp. The isavuconazole ECVs based on wild-type (WT) MIC distributions for 438 Cryptococcus neoformans nongenotyped isolates, 870 isolates of genotype VNI, and 406 Cryptococcus gattii isolates from six laboratories and different geographical areas were 0.06, 0.12, and 0.25 μg/ml, respectively. These ECVs may aid in detecting non-WT isolates with reduced susceptibilities to isavuconazole.
authors.affiliation: VCU Medical Center, Richmond, Virginia, USA avingrof@vcu.edu.
authors.forename: A
authors.initials: A
authors.lastname: Espinel-Ingroff
authors.affiliation: Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Chowdhary
authors.affiliation: Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
authors.forename: G M
authors.initials: GM
authors.lastname: Gonzalez
authors.affiliation: Hospital General Universitario Gregorio Marañón, School of Medicine-Universidad Complutense, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Guinea
authors.affiliation: Department of Medical Microbiology & Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: Hagen
authors.affiliation: Department of Medical Microbiology & Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
authors.forename: J F
authors.identifier: http://orcid.org/0000-0003-3253-6080
authors.initials: JF
authors.lastname: Meis
authors.affiliation: University of California Davis Medical Center, Davis, California, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Thompson
authors.affiliation: University of Adelaide, Adelaide, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Turnidge
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003453:Cryptococcosis / Q000188:drug therapy; D056285:Cryptococcus gattii / Q000187:drug effects* / Q000235:genetics; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000235:genetics; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D009570:Nitriles / Q000494:pharmacology* / Q000627:therapeutic use; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D014230:Triazoles / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; C508735:isavuconazole