title: Rationally designed multifunctional supramolecular iminium catalysis: direct vinylogous Michael addition of unmodified linear dienol substrates.
abstract: The development of a direct vinylogous Michael addition of linear nucleophilic substrates is a long-standing challenge because of the poor reactivity and the considerable difficulty in controlling regioselectivity. By employing a rationally designed multifunctional supramolecular iminium catalysis strategy, the first direct vinylogous Michael addition of unmodified linear substrates to α,β-unsaturated aldehydes, to afford chiral 1,7-dioxo compounds with good yields and excellent regio- as well as enantioselectivity, has been developed.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 (China).
authors.forename: Yun
authors.initials: Y
authors.lastname: Gu
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Tian-Yang
authors.initials: TY
authors.lastname: Yu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Xu
keywords: Michael addition; asymmetric catalysis; regioselectivity; supramolecular chemistry; synthetic methods