title: The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans.
abstract: The in vitro and in vivo activity of the inositol acyltransferase inhibitor E1210 was evaluated against echinocandin-resistant Candida albicans. E1210 demonstrated potent in vitro activity, and in mice with invasive candidiasis caused by echinocandin-resistant C. albicans, oral doses of 10 and 40 mg E1210/kg of body weight twice daily significantly improved survival and reduced fungal burden compared to those of controls and mice treated with caspofungin (10 mg/kg/day). These results demonstrate the potential use of E1210 against resistant C. albicans infections.
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA wiederholdn@uthscsa.edu.
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Annette W
authors.initials: AW
authors.lastname: Fothergill
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
authors.forename: Dora I
authors.initials: DI
authors.lastname: McCarthy
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Marcos
authors.initials: M
authors.lastname: Olivo
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Kirkpatrick
authors.affiliation: Eisai Inc., Woodcliff Lake, New Jersey, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Everson
authors.affiliation: Eisai Inc., Woodcliff Lake, New Jersey, USA.
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Duncanson
authors.affiliation: University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA South Texas Veterans Health Care System, San Antonio, Texas, USA.
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D058365:Candidiasis, Invasive / Q000188:drug therapy*; D000077336:Caspofungin; D004305:Dose-Response Relationship, Drug; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology / Q000627:therapeutic use; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D007555:Isoxazoles / Q000494:pharmacology* / Q000627:therapeutic use; D055666:Lipopeptides; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008826:Microbial Sensitivity Tests
chemical_list: C570438:APX001A; D000631:Aminopyridines; D000935:Antifungal Agents; D054714:Echinocandins; D007555:Isoxazoles; D055666:Lipopeptides; D015725:Fluconazole; D000077336:Caspofungin