title: Evaluation of serum anti-Mullerian hormone as a biomarker of early ovarian aging in young women undergoing IVF/ICSI cycle.
abstract: OBJECTIVE
  To determine whether or not the level of serum anti-Müllerian hormone (AMH) is related to early ovarian aging in young women (< 35 years of age) undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  An IVF laboratory in a university hospital in Taiwan. Patient (s): 70 young women (< 35 years of age) with low level of serum AMH (< 2 ng/ml) and 104 young women with level of serum AMH (≥ 2 ng/ml) who underwent IVF/ICSI cycles between January 2011 and November 2012 were enrolled. Intervention (s): None. Main outcome measure (s): Number of oocytes, fertilization rate, embryo quality, cycle cancellation rate, clinical pregnancy/abortion rate, and perinatal/infant outcomes.
  
  
  RESULTS
  The clinical pregnancy rate per transfer was favorable (low AMH group vs. normal AMH group [47.2% and 47.9%]) for women < 35 years of age, including women with a low serum AMH. Similarly, the live birth rate per transfer (low AMH group vs. normal AMH group [37.7% and 35.4%]) and perinatal outcomes were also comparable between the two groups. A significantly higher cycle cancellation was noted in the low AMH group than the normal AMH group (24.2% vs. 7.6%).
  
  
  CONCLUSIONS
  Although early ovarian aging should be taken into consideration for young and infertile women with low AMH level than expected, our results suggest that low serum AMH level may suggest early ovarian aging in accelerated oocyte loss only, but may not fully represent "early ovarian aging" based on the favorable outcomes of pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Pin-Yao
authors.initials: PY
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Fu-Jen
authors.initials: FJ
authors.lastname: Huang
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Fu-Tsai
authors.initials: FT
authors.lastname: Kung
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Hsin-Ju
authors.initials: HJ
authors.lastname: Chiang
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Yi-Chi
authors.initials: YC
authors.lastname: Lin
authors.affiliation: Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Kaohsiung, 123 Ta-Pei Road, Niaosung Dist, Kaohsiung, Taiwan.
authors.forename: Kuo-Chung
authors.initials: KC
authors.lastname: Lan
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D005298:Fertility; D005307:Fertilization in Vitro; D006785:Hospitals, University; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D008297:Male; D010050:Ovarian Function Tests; D010053:Ovary / Q000378:metabolism* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013624:Taiwan; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D054304:Anti-Mullerian Hormone
keywords: Anti-müllerian hormone; early ovarian aging; low ovarian reserve; perinatal outcomes; pregnancy outcomes