title: Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma.
abstract: OBJECTIVE
  Using anterior chamber optical coherence tomography to evaluate changes in angle anatomy in patients with primary angle-closure glaucoma (PACG) before and after trabeculectomy.
  
  
  METHODS
  This is a prospective observational study in 38 eyes of 38 patients with PACG, who underwent trabeculectomy. We used customized software to analyze optical coherence tomography images (Visante) of all participants before and after the surgical treatment. Multivariate linear regression analysis was performed for predictors of percentage change in mean angle parameters, including scleral spur angle, angle opening distance, angle recess area, and trabecular-iris surface area. The main outcome measures were changes in angle parameters and their relationship with age, sex, refraction, MD, visual outcomes, central corneal thickness, axial length of eye, number of glaucoma bottles, baseline intraocular pressure (IOP), and percentage changes in IOP (ΔIOP).
  
  
  RESULTS
  There was a significant increase in all angle parameters at the follow-up examination compared with the baseline value (all P<0.001). After multivariate analysis, the only variable related to changes in all angle parameters was ΔIOP.
  
  
  CONCLUSIONS
  Trabeculectomy results in a significant increase in the angle width in PACG. The increase in angle parameters was significantly related to the IOP changes.
authors.affiliation: *Department of Ophthalmology and Visual Science, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical College ‡Health Communication Institute, Fudan University §State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Shanghai †Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen University, Xiamen, China.
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Hong
authors.forename: Junyi
authors.initials: J
authors.lastname: Chen
authors.forename: Yujing
authors.initials: Y
authors.lastname: Yang
authors.forename: Anji
authors.initials: A
authors.lastname: Wei
authors.forename: Xiangmei
authors.initials: X
authors.lastname: Kong
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Yu
authors.forename: Chunhui
authors.initials: C
authors.lastname: Jiang
authors.forename: Zuguo
authors.initials: Z
authors.lastname: Liu
authors.forename: Xinghuai
authors.initials: X
authors.lastname: Sun
authors.forename: Jianjiang
authors.initials: J
authors.lastname: Xu
mesh_terms: D000368:Aged; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D007498:Iris / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular; D014129:Trabecular Meshwork / Q000473:pathology*; D014130:Trabeculectomy