title: Antidiabetic effect of the α-lipoic acid γ-cyclodextrin complex.
abstract: In recent years, the number of patients suffering from diabetes mellitus has been increasing worldwide. In particular, type 2 diabetes mellitus, a lifestyle-related disease, is recognized as a serious disease with various complications. Many types of pharmaceutics or specific health foods have been used for the management of diabetes mellitus. At the same time, the relationship between diabetes mellitus and α-lipoic acid has been recognized for many years. In this study, we found that the α-lipoic acid γ-cyclodextrin complex exhibited an HbA1c lowering effect for treating type 2 diabetes mellitus in animal models. Moreover, in this study, we investigated the activation of phosphorylation of AMP-activated protein kinase, which plays a role in cellular energy homeostasis, in the liver of KKA(y) mice by using α-lipoic acid and the α-lipoic acid γ-cyclodextrin complex. Our results show that the α-lipoic acid γ-cyclodextrin complex strongly induced the phosphorylation of AMP-activated protein kinase. Thus, we concluded that intake of the α-lipoic acid γ-cyclodextrin complex exerted an antidiabetic effect by suppressing the elevation of postprandial hyperglycemia as well as doing exercise.
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Yuki
authors.initials: Y
authors.lastname: Naito
authors.affiliation: Department of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Ikuta
authors.affiliation: CycloChem Bio Co., Ltd., KIBC 654R, 5-5-2, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nakata
authors.affiliation: Department of Social/Community Medicine and Health Science, Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan ; CycloChem Bio Co., Ltd., KIBC 654R, 5-5-2, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Terao
authors.affiliation: Department of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
authors.forename: Kinuyo
authors.initials: K
authors.lastname: Matsumoto
authors.affiliation: Department of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
authors.forename: Naemi
authors.initials: N
authors.lastname: Kajiwara
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Okano
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Chemistry, Kyoto Pharmaceutical University, 5, Misasagi-Nakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan ; Department of Health and Sports Nutrition, Faculty of Health and Welfare, Kobe Women's University, 4-7-2, Minatojima-Nakamachi, Chuo-ku, Kobe 650-0046, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshikawa
keywords: antidiabetic effect; type 2 diabetes mellitus; α-lipoic acid; γCD complex