title: Minimized extracorporeal circulation does not impair cognitive brain function after coronary artery bypass grafting.
abstract: OBJECTIVE
  Objective evaluation of the impact of minimized extracorporeal circulation (MECC) on perioperative cognitive brain function in coronary artery bypass grafting (CABG) by electroencephalogram P300 wave event-related potentials and number connection test (NCT) as metrics of cognitive function.
  
  
  METHODS
  Cognitive brain function was assessed in 31 patients in 2013 with a mean age of 65 years [standard deviation (SD) 10] undergoing CABG by the use of MECC with P300 auditory evoked potentials (peak latencies in milliseconds) directly prior to intervention, 7 days after and 3 months later. Number connection test, serving as method of control, was performed simultaneously in all patients.
  
  
  RESULTS
  Seven days following CABG, cognitive P300 evoked potentials were comparable with preoperative baseline values [vertex (Cz) 376 (SD 11) ms vs 378 (18) ms, P = 0.39; frontal (Fz) 377 (11) vs 379 (21) ms, P = 0.53]. Cognitive brain function at 3 months was compared with baseline values [(Cz) 376 (11) ms vs 371 (14 ms) P = 0.09; (Fz) 377 (11) ms vs 371 (15) ms, P = 0.04]. Between the first postoperative measurement and 3 months later, significant improvement was observed [(Cz) 378 (18) ms vs 371 (14) ms, P = 0.03; (Fz) 379 (21) vs 371 (15) ms, P = 0.02]. Similar clearly corresponding patterns could be obtained via the number connection test. Results could be confirmed in repeated measures analysis of variance for Cz (P = 0.05) and (Fz) results (P = 0.04).
  
  
  CONCLUSIONS
  MECC does not adversely affect cognitive brain function after CABG. Additionally, these patients experience a substantial significant cognitive improvement after 3 months, evidentiary proving that the concept of MECC ensures safety and outcome in terms of brain function.
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Reineke
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland bernhard.winkler@insel.ch.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Winkler
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland.
authors.forename: Tobias
authors.initials: T
authors.lastname: König
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland.
authors.forename: Katharina
authors.initials: K
authors.lastname: Meszaros
authors.affiliation: Department of Emergency Medicine, Medical University of Vienna, Vienna, Austria.
authors.forename: Gottfried
authors.initials: G
authors.lastname: Sodeck
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland.
authors.forename: Florian
authors.initials: F
authors.lastname: Schönhoff
authors.affiliation: Department of Anesthesiology, University Hospital Berne, Berne, Switzerland.
authors.forename: Gabor
authors.initials: G
authors.lastname: Erdoes
authors.affiliation: Department of Anesthesiology, University Hospital Berne, Berne, Switzerland.
authors.forename: Martin
authors.initials: M
authors.lastname: Czerny
authors.affiliation: Department of Cardiovascular Surgery, University Hospital Berne, Berne, Switzerland.
authors.forename: Thierry
authors.initials: T
authors.lastname: Carrel
mesh_terms: D000368:Aged; D001921:Brain / Q000503:physiopathology*; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D001026:Coronary Artery Bypass / Q000009:adverse effects; D004569:Electroencephalography; D018913:Event-Related Potentials, P300; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011930:Reaction Time; D020127:Recovery of Function; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Brain function; Coronary artery bypass grafting; Minimized extracorporeal circulation circuit