title: Antibiotic sensitivity pattern from pregnant women with urinary tract infection in Bangalore, India.
abstract: OBJECTIVE
  To determine the antibacterial profile of pregnant women with urinaty tract infections and analyze the antibiotic sensitivity pattern for the effective treatment.
  
  
  METHODS
  A total of 395 urine samples from pregnant women with different gestational age were processed for the isolation of uropathogens and tested against eight groups of antibiotics namely penicillins, cephalosporins, fluoroquinolones, aminoglycosides, macrolides, lincosamides, glycopeptides and sulfonamides.
  
  
  RESULTS
  A positive culture percentage of 46.6% was obtained with the highest urinary tract infection in third trimester gestational age. Among the uropathogens isolated, 85.6% were Gram negative and 14.4% were Gram positive with Escherichia coli as the predominant bacteria (43.9%) followed by Klebsiella oxytoca (19.4%) and Klebsiella pneumoniae (13.3%). Antibiotic sensitivity assay revealed that amikacin had the highest overall sensitivity (n=136; 76.7%) and the subsequent highest sensitivity was observed with ciprofloxacin (n=132; 73.3%), clindamycin (n=124; 68.9%), cefotaxime (n=117; 65%) and nalidixic acid (n=115; 63.9%).
  
  
  CONCLUSIONS
  The findings revealed that uropathogens were more resistant to penicillins, macrolides and glycopeptides which restrict their use in treating urinaty tract infections during pregnancy. In conclusion, common causative bacteria and their antibiotic sensitivity pattern are to be determined along with their safety to mother and fetus for the effective treatment of urinary tract infections during pregnancy.
authors.affiliation: Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, India. Electronic address: gsibii@gmail.com.
authors.forename: G
authors.initials: G
authors.lastname: Sibi
authors.affiliation: Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, India.
authors.forename: Pinki
authors.initials: P
authors.lastname: Kumari
authors.affiliation: Department of Biotechnology, Indian Academy Degree College, Centre for Research and Post Graduate Studies, Bangalore, India.
authors.forename: Neema
authors.initials: N
authors.lastname: Kabungulundabungi
keywords: Amikacin; Pregnancy; Urinary tract infection; Uropathogens