title: MMP-2 responsive polymeric micelles for cancer-targeted intracellular drug delivery.
abstract: Multifunctional Biotin-PEG-b-PLL(Mal)-peptide-DOX polymeric micelles were prepared to selectively eliminate cancer cells. The micelles were able to enhance cancer cell uptake via the receptor-mediated endocytosis and respond to the stimulus of cancer cell excessive secreted protease MMP-2 to release the anticancer drug and induce apoptosis of cancer cells in a targeted manner.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China. wangqr@whu.edu.cn xz-zhang@whu.edu.cn.
authors.forename: Wei-Hai
authors.initials: WH
authors.lastname: Chen
authors.forename: Guo-Feng
authors.initials: GF
authors.lastname: Luo
authors.forename: Qi
authors.initials: Q
authors.lastname: Lei
authors.forename: Hui-Zhen
authors.initials: HZ
authors.lastname: Jia
authors.forename: Sheng
authors.initials: S
authors.lastname: Hong
authors.forename: Qing-Rong
authors.initials: QR
authors.lastname: Wang
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D008823:Micelles; D018613:Microscopy, Confocal; D008954:Models, Biological; D011108:Polymers / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011108:Polymers; D020778:Matrix Metalloproteinase 2