title: [Pharmacological correction of the ulcerogenic action of NSAIDs in rats].
abstract: Experimental preclinical investigations on a group of 90 white outbred male rats showed that preliminary preventive introduction of procaine (novocaine, 1.07 mg/kg) or taurine (7.14 mg/kg) during 7 days before the administration of ketorolak trometamine significantly reduced the number of erosive-ulcerous lesions (by more than 87%, p < 0.001) and decreased the extent of pathological changes in the morphological structure of stomach mucus membrane.
authors.forename: D B
authors.initials: DB
authors.lastname: Kholodov
authors.forename: V A
authors.initials: VA
authors.lastname: Nikolaevskiĭ
authors.forename: S M
authors.initials: SM
authors.lastname: Suleĭmanov
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Chernov
authors.forename: A V
authors.initials: AV
authors.lastname: Buzlama
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000494:pharmacology; D020911:Ketorolac Tromethamine / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D013654:Taurine / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013654:Taurine; D020911:Ketorolac Tromethamine; D011343:Procaine