title: Workshop report: Identifying opportunities for global integration of toxicogenomics databases, 26-27 June 2013, Research Triangle Park, NC, USA.
abstract: A joint US-EU workshop on enhancing data sharing and exchange in toxicogenomics was held at the National Institute for Environmental Health Sciences. Currently, efficient reuse of data is hampered by problems related to public data availability, data quality, database interoperability (the ability to exchange information), standardization and sustainability. At the workshop, experts from universities and research institutes presented databases, studies, organizations and tools that attempt to deal with these problems. Furthermore, a case study showing that combining toxicogenomics data from multiple resources leads to more accurate predictions in risk assessment was presented. All participants agreed that there is a need for a web portal describing the diverse, heterogeneous data resources relevant for toxicogenomics research. Furthermore, there was agreement that linking more data resources would improve toxicogenomics data analysis. To outline a roadmap to enhance interoperability between data resources, the participants recommend collecting user stories from the toxicogenomics research community on barriers in data sharing and exchange currently hampering answering to certain research questions. These user stories may guide the prioritization of steps to be taken for enhancing integration of toxicogenomics databases.
authors.affiliation: Department of Toxicogenomics, Maastricht University, Universiteitssingel 40, 6229 ER, Maastricht, The Netherlands, d.hendrickx@maastrichtuniversity.nl.
authors.forename: Diana M
authors.initials: DM
authors.lastname: Hendrickx
authors.forename: Rebecca R
authors.initials: RR
authors.lastname: Boyles
authors.forename: Jos C S
authors.initials: JC
authors.lastname: Kleinjans
authors.forename: Allen
authors.initials: A
authors.lastname: Dearry
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D015386:Hazardous Substances / Q000633:toxicity*; D006801:Humans; D007391:International Cooperation; D054585:National Institute of Environmental Health Sciences (U.S.); D009657:North Carolina; D043922:Toxicogenetics / Q000379:methods*; D059467:Transcriptome / Q000187:drug effects; D014481:United States
chemical_list: D015386:Hazardous Substances