title: Transplantation of neurotrophin-3-transfected bone marrow mesenchymal stem cells for the repair of spinal cord injury.
abstract: Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. However, the low survival rate of transplanted bone marrow mesenchymal stem cells in vivo remains a problem. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its transfection can enhance the therapeutic effect. We show that in vitro transfection of neurotrophin-3 gene increases the number of bone marrow mesenchymal stem cells in the region of spinal cord injury. These results indicate that neurotrophin-3 can promote the survival of bone marrow mesenchymal stem cells transplanted into the region of spinal cord injury and potentially enhance the therapeutic effect in the repair of spinal cord injury.
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Yuzhen
authors.initials: Y
authors.lastname: Dong
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Libin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
authors.forename: Dapeng
authors.initials: D
authors.lastname: Wu
keywords: bone marrow mesenchymal stem cells; cell apoptosis; cell transplantation; nerve regeneration; neural regeneration; neurotrophin-3; spinal cord anterior horn motor neurons; spinal cord injury