title: Systematic study of stress-inducible protein 1 (Stip1) in male reproductive system and its expression during stress response.
abstract: Stress-inducible protein 1 (Stip1) is one of the well-studied co-chaperones, although limited researches have been conducted in testis and epididymis. Here we found that Stip1 was ubiquitously expressed in various human tissues, including the testis and epididymis. In human testis and epididymis, Stip1 was localized in the cytoplasm of diverse cell types. Stip1 showed a developmentally-regulated manner and it was up-regulated after heat shock in rat testis and epididymis. However, the expression of Stip1 was significantly down-regulated in the testis, with tremendous histomorphological changes under oxidative stress. This study will lay the foundation for revealing the mechanism of Stip1 in the male reproductive system.
authors.affiliation: Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Clinical Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China.
authors.forename: Shaohua
authors.initials: S
authors.lastname: Jin
authors.affiliation: Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.affiliation: Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Life Science, Yantai University, Yantai 264000, Shandong Province, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.affiliation: Central Laboratory, Yuhuangding Hospital, Yantai, Shandong Province, PR China; College of Life Science, Yantai University, Yantai 264000, Shandong Province, PR China. Electronic address: yanlichn@outlook.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D000328:Adult; D000818:Animals; D015536:Down-Regulation; D004317:Doxorubicin / Q000737:chemistry; D004822:Epididymis / Q000378:metabolism*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: D006360:Heat-Shock Proteins; C079373:STIP1 protein, human; C489790:Stip1 protein, rat; D008315:Malondialdehyde; D004317:Doxorubicin
keywords: Heat shock; Male reproductive system; Oxidative stress; Stip1