title: N-tosyl-3-azacyclohexyne. Synthesis and chemistry of a strained cyclic ynamide.
abstract: The first synthesis of a strained six-membered cyclic ynamide is described. N-Tosyl-3-azacyclohexyne is generated via fluoride-promoted 1,2 elimination under conditions that allow trapping of the strained heterocyclic alkyne in a variety of addition, insertion, and [2 + 2], [3 + 2], and [4 + 2] cycloaddition reactions.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Sami F
authors.initials: SF
authors.lastname: Tlais
authors.forename: Rick L
authors.initials: RL
authors.lastname: Danheiser