title: Retinal toxicity after intracameral use of a standard dose of cefuroxime during cataract surgery.
abstract: OBJECTIVE
  We report the clinical findings and retinal function of a patient who presented retinal toxicity signs after cefuroxime use for a phacoemulsification surgery.
  
  
  METHODS
  A 64-year-old man underwent a technically uneventful left eye cataract surgery. A standard intracameral dose of cefuroxime (0.1 mL of 10.0 mg/mL solution) was administered at the end of the surgery.
  
  
  RESULTS
  At review 2 days later, he complained about left eye visual loss. Fundus examination revealed a diffuse retinal pallor with small intraretinal cysts. Optical coherence tomography scans showed a large retinal serous detachment with a schisis-like appearance of the outer nuclear layer. A slight global retinal dysfunction was recorded on ISCEV full-field electroretinogram. Fast clinical recovery was observed. Optical coherence tomography scans were back to normal within less than a week. Two months later, full-field electroretinogram showed no longer abnormalities.
  
  
  CONCLUSIONS
  It is the first report to our knowledge of a case of retinal toxicity with a standard dose. Kinetics and studies about cefuroxime toxicity are reviewed and discussed.
authors.affiliation: Fondation Ophtalmologique Adolphe de Rothschild, 25 rue Manin, 75019, Paris, France, celinefaureoph@gmail.com.
authors.forename: Céline
authors.initials: C
authors.lastname: Faure
authors.forename: Daniel
authors.initials: D
authors.lastname: Perreira
authors.forename: Isabelle
authors.initials: I
authors.lastname: Audo
mesh_terms: D000867:Anterior Chamber / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D002444:Cefuroxime / Q000633:toxicity*; D004596:Electroretinography; D009877:Endophthalmitis / Q000517:prevention & control; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D012160:Retina / Q000187:drug effects*; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D041623:Tomography, Optical Coherence
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime