title: Rare case of endometrioid adenocarcinoma arising from cystic adenomyosis.
abstract: Few reports on malignant transformation of adenomyosis are available, and endometrioid adenocarcinoma arising from cystic adenomyosis is further rarely reported. We report a case of a 67-year-old asymptomatic woman who was referred to our hospital for evaluation of a cystic lesion in the pelvis, which had been diagnosed as cystic degeneration of leiomyoma for 3 years. Magnetic resonance imaging revealed a cystic mass measuring 11 cm in diameter, which was contiguous with uterine myometrium. The lesion contained solid areas enhanced on gadolinium-enhanced T1 -weighted imaging. Transabdominal simple total hysterectomy with bilateral salpingo-oophorectomy was performed. Pathological examination revealed endometrioid adenocarcinoma arising from cystic adenomyosis. The patient underwent six courses of adjuvant combination chemotherapy with paclitaxel and carboplatin. No metastasis or recurrence has been demonstrated for 16 months following surgery. Our case demonstrates that cystic adenomyoma possesses the risk of malignant transformation, indicating the importance of long-term follow-up with imaging examination.
authors.affiliation: Department of Gynecology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
authors.forename: Mayuyo
authors.initials: M
authors.lastname: Mori
authors.forename: Akiko
authors.initials: A
authors.lastname: Furusawa
authors.forename: Nao
authors.initials: N
authors.lastname: Kino
authors.forename: Masaya
authors.initials: M
authors.lastname: Uno
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yasugi
mesh_terms: D018194:Adenomyoma / Q000473:pathology*; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000473:pathology / Q000628:therapy*; D002471:Cell Transformation, Neoplastic; D016889:Endometrial Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans
keywords: cystic adenomyosis; endometrioid adenocarcinoma; magnetic resonance imaging; malignant transformation