title: Expedient synthesis of complex γ-butyrolactones from 5-(1-arylalkylidene) meldrum's acids via sequential conjugate alkynylation/Ag(I)-catalyzed lactonization.
abstract: The conjugate alkynylation of alkylidene Meldrum's acids with alkynylalanes and alkynyl Grignards allows for the formation of propargylic all-carbon quaternary stereocenters in high yields. Ag2CO3-catalyzed intramolecular cyclization of propargylic Meldrum's acid derivatives offers a two-step entry into complex γ-alkylidene butyrolactones containing an all-carbon quaternary center at the C-4 position.
authors.affiliation: Department of Chemistry, University of Waterloo , Waterloo, Ontario N2L 3G1, Canada.
authors.forename: Siawash
authors.initials: S
authors.lastname: Ahmar
authors.forename: Eric
authors.initials: E
authors.lastname: Fillion