title: Bayesian network analysis revealed the connectivity difference of the default mode network from the resting-state to task-state.
abstract: Functional magnetic resonance imaging (fMRI) studies have converged to reveal the default mode network (DMN), a constellation of regions that display co-activation during resting-state but co-deactivation during attention-demanding tasks in the brain. Here, we employed a Bayesian network (BN) analysis method to construct a directed effective connectivity model of the DMN and compared the organizational architecture and interregional directed connections under both resting-state and task-state. The analysis results indicated that the DMN was consistently organized into two closely interacting subsystems in both resting-state and task-state. The directed connections between DMN regions, however, changed significantly from the resting-state to task-state condition. The results suggest that the DMN intrinsically maintains a relatively stable structure whether at rest or performing tasks but has different information processing mechanisms under varied states.
authors.affiliation: College of Information Science and Technology, Beijing Normal University Beijing, China ; State Key Laboratories of Transducer Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences Shanghai, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wu
authors.affiliation: College of Information Science and Technology, Beijing Normal University Beijing, China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Yu
authors.affiliation: College of Information Science and Technology, Beijing Normal University Beijing, China ; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.affiliation: Center on Aging Psychology, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
keywords: Bayesian network (BN); default mode network (DMN); effective connectivity (EC); functional connectivity (FC); functional magnetic resonance imaging (fMRI)