title: A case of pediatric acute lymphoblastic leukemia with invasive candidiasis: short review.
abstract: Mortality rate associated with invasive fungal infections is very high. Early suspicion for fungal infections is important during intensive chemotherapy for acute leukemia. Empirical treatment with antifungals amphotericin B or caspofungin should be started if patient is not responding to broad spectrum antibiotics and if expected duration of neutropenia is prolonged. We are reporting a 3 years old girl child with diagnosis of pre-B acute lymphoblastic leukemia who developed invasive candidiasis with typical clinical and radiological findings during induction chemotherapy. Candida non-albicans was isolated and she was treated with amphotericin B followed by caspofungin. Patient deteriorated after initial response and succumbed to death. Species identification and sensitivity pattern of fungus can help in selecting appropriate antifungal drug.
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: S P
authors.initials: SP
authors.lastname: Verma
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: B
authors.initials: B
authors.lastname: Dubashi
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: P
authors.initials: P
authors.lastname: Narayanan
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: D
authors.initials: D
authors.lastname: Basu
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Dutta
authors.affiliation: JIPMER, Pondicherry, India.
authors.forename: K M
authors.initials: KM
authors.lastname: Dhanraj
keywords: Acute lymphoblastic leukemia; Candida non-albicans; Invasive candidiasis