title: SOX2 as prognostic factor in head and neck cancer: a systematic review and meta-analysis.
abstract: CONCLUSIONS
  SOX2-positive head and neck cancer patients had a worse prognosis, and this was associated with common clinicopathological poor prognostic factors.
  
  
  OBJECTIVE
  To investigate the correlation between SOX2-positive head and neck cancer and clinicopathological features and its impact on survival.
  
  
  METHODS
  A search in PubMed and Chinese CNKI (up to 1 July 2013) was performed. Only articles in which SOX2 antigen was detected in situ localization by immunohistochemical staining were included. This meta-analysis was done using RevMan 5.2 software. Outcomes included overall survival and various clinicopathological features.
  
  
  RESULTS
  A total of 926 gastric cancer patients from 9 studies were included. Meta-analysis showed that patients with SOX2 expression had a significantly worse 5-year overall survival compared with those with low expression (relative risk (RR) = 2.38, 95% confidence interval (CI) = 1.10-5.15, p = 0.03, random-effect). With respect to clinicopathological features, SOX2 overexpression as assessed by the immunohistochemistry method was closely correlated with tumor T stage, lymph node metastasis, and TNM stage.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Institute of Otolaryngology, Chinese PLA General Hospital, Chinese PLA Medical School , Beijing.
authors.forename: Weimin
authors.initials: W
authors.lastname: Li
authors.forename: Baoping
authors.initials: B
authors.lastname: Li
authors.forename: Rongguang
authors.initials: R
authors.lastname: Wang
authors.forename: Dongyan
authors.initials: D
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Shiming
authors.initials: S
authors.lastname: Yang
mesh_terms: D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D011379:Prognosis; D055748:SOXB1 Transcription Factors / Q000378:metabolism*
chemical_list: C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors
keywords: Cancer stem cells; clinicopathological features; overall survival; prognosis