title: An update on prodrugs from natural products.
abstract: A natural prodrug is a chemical compound or substance obtained from plants, microorganism, animal and marine sources. Natural products are small molecule source for Food and Drug Administration approved drugs and major sources for drug discovery. Most of the drugs for different ailment diseases undergo first pass metabolism, resulting in drug inactivation and the generation of toxic metabolites in body. Enormous numbers of prodrugs naturally present in plants, microorganism, animal and marine sources and those prodrugs undergoes chemical reaction to form non-toxic compounds. This review summarizes the list of prodrugs naturally present in the natural product.
authors.affiliation: Gokula Krishna College of Pharmacy, Sullurpet-524121, Nellore Dist, A.P, India.
authors.forename: Sekar Vinoth
authors.initials: SV
authors.lastname: Kumar
authors.affiliation: Ratnam Institute of Pharmacy, Pidathapolur, Nellore-524346, Andhra Pradesh, India. Electronic address: devasaro@yahoo.co.in.
authors.forename: Devarajan
authors.initials: D
authors.lastname: Saravanan
authors.affiliation: Ratnam Institute of Pharmacy, Pidathapolur, Nellore-524346, Andhra Pradesh, India.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Kumar
authors.affiliation: Ratnam Institute of Pharmacy, Pidathapolur, Nellore-524346, Andhra Pradesh, India.
authors.forename: Annamalai
authors.initials: A
authors.lastname: Jayakumar
keywords: Natural products; Pharmacology; Prodrugs