title: Risk factors for the evaluation of potential central nervous system metastasis in Burkitt's lymphoma: a case study and literature review.
abstract: Burkitt's lymphoma (BL) is a malignancy of B lymphocytes. The rapid growth rate and frequent systemic spread result in most patients presenting with advanced disease at diagnosis. Cerebrospinal fluid cytology is the gold standard (with very high accuracy) for diagnosing BL central nervous system (CNS) metastasis; however, the low sensitivity of this method limits its clinical applications. Here, we report a case of BL with CNS metastasis. The levels of vascular endothelial growth factor (VEGF)-A and VEGF-C in the serum and cerebrospinal fluid were used to evaluate the status of BL remission and recurrence. Comparisons were made between VEGF and the other risk factors used in evaluating CNS metastasis. Although not in strict accordance, VEGF levels mirrored the disease course. Therefore, VEGF may reflect the status of BL CNS metastasis. Understanding the role of VEGF in CNS metastasis may help to improve the staging and risk classification of BL as well as the investigation of targeted therapy.
authors.affiliation: Department of Hematology Laboratory, First Affiliated Hospital Of Shantou University Medical College, Guangdong, China.
authors.forename: Yue-Ting
authors.initials: YT
authors.lastname: Tang
authors.affiliation: Department of cell biology and genetics, Shantou University Medical College, Guangdong, China.|Department of Hematology Laboratory, First Affiliated Hospital Of Shantou University Medical College, Guangdong, China.
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Jiao
authors.affiliation: Department of cell biology and genetics, Shantou University Medical College, Guangdong, China.
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Chang
authors.affiliation: Department of cell biology and genetics, Shantou University Medical College, Guangdong, China.
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Huang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology*; D002051:Burkitt Lymphoma / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000453:epidemiology / Q000473:pathology*; D002555:Cerebrospinal Fluid / Q000166:cytology; D004172:Diplopia / Q000209:etiology; D005260:Female; D006261:Headache / Q000209:etiology; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000097:blood / Q000134:cerebrospinal fluid; D012008:Recurrence; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000134:cerebrospinal fluid; D042582:Vascular Endothelial Growth Factor C / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D014408:Biomarkers, Tumor; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042582:Vascular Endothelial Growth Factor C
keywords: Burkitt's lymphoma; Central nervous system leukaemia; Cerebrospinal fluid; VEGF-A; VEGF-C