title: Philadelphia chromosome positive pre-T cell acute lymphoblastic leukemia: a rare case report and short review.
abstract: Pre-T cell acute lymphoblastic leukemia is a relatively rare leukemia. Twenty to 30 % of adult B cell leukemia cases are Philadelphia chromosome positive and it has a therapeutic and prognostic significance. Incidence and outcome of Ph+ T cell acute lymphoblastic leukemia (T cell ALL) is unknown. Only about 25 cases of de novo Ph+ T cell ALL and 44 cases of Ph+ T ALL in blastic phase of CML has been reported. Differentiation between Ph+ Pre-T ALL/LBL and T cell lymphoblastic crises of chronic myeloid leukemia may be difficult. We report a case of adult T cell ALL having Philadelphia chromosome as the cytogenetic abnormality. He was treated with acute lymphoblastic leukemia induction chemotherapy and Imatinib and achieved complete remission.
authors.affiliation: Division of Clinical Haematology, Department of Medicine, JIPMER, Pondicherry, India.
authors.forename: Shailendra Prasad
authors.initials: SP
authors.lastname: Verrma
authors.affiliation: Division of Clinical Haematology, Department of Medicine, JIPMER, Pondicherry, India.
authors.forename: Tarun Kumar
authors.initials: TK
authors.lastname: Dutta
authors.affiliation: Department of Medicine, JIPMER, Pondicherry, India.
authors.forename: K V
authors.initials: KV
authors.lastname: Vinod
authors.affiliation: Department of Medical Oncology, JIPMER, Pondicherry, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Dubashi
authors.affiliation: Department of Medicine, JIPMER, Pondicherry, India.
authors.forename: Kishore Kumar
authors.initials: KK
authors.lastname: Ariga
keywords: Philadelphia chromosome positive (Ph+); T cell acute lymphoblastic leukemia (T cell ALL)