title: High adiposity and serum leptin accompanied by altered bone turnover markers in severe juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To evaluate interactions between skeleton and adipose tissue, and association of adipokines and bone turnover markers with disease-related factors in patients with severe juvenile idiopathic arthritis (JIA).
  
  
  METHODS
  Forty-nine patients (median age 14.8 yrs, median disease duration 10.2 yrs) with refractory polyarticular JIA and 89 sex-matched and age-matched healthy controls participated in the study. Study subjects underwent clinical examination, body composition assessment with dual-energy X-ray absorptiometry, and analyses for leptin, adiponectin, and bone turnover markers.
  
  
  RESULTS
  Patients with JIA were shorter and more often overweight (p = 0.001) or obese (p < 0.001) than controls. They had significantly higher serum leptin, even when adjusted for fat mass (p < 0.001), than did controls. Adiponectin did not differ between the groups. Concentration of carboxyterminal telopeptide of type I collagen was higher (p = 0.006) in patients. The inverse association between leptin and bone turnover markers disappeared in controls but was strengthened in patients when adjusted for fat mass. Leptin, adiponectin, or bone markers did not associate with variables of disease activity.
  
  
  CONCLUSIONS
  Patients with severe JIA had high adiposity accompanied by increased bone resorption. Their serum leptin was higher, even independently of fat mass. Leptin tended to associate inversely with bone turnover markers but did not associate with variables of disease activity.
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki. kati.markula-patjas@pshp.fi.
authors.forename: Kati P
authors.initials: KP
authors.lastname: Markula-Patjas
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Kaisa K
authors.initials: KK
authors.lastname: Ivaska
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Minna
authors.initials: M
authors.lastname: Pekkinen
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Sture
authors.initials: S
authors.lastname: Andersson
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Heli T
authors.initials: HT
authors.lastname: Viljakainen
authors.affiliation: From the Pediatric Research Center, University of Tampere and Tampere University Hospital, Tampere; Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku;Folkhälsan Research Center; Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere, Finland.K.P. Markula-Patjas, MD, Pediatric Research Center, University of Tampere and Tampere University Hospital; K.K. Ivaska, PhD, Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku; M. Pekkinen, PhD, Folkhälsan Research Center; S. Andersson, MD, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; E. Moilanen, MD, PhD, The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital; H.T. Viljakainen, PhD, Children's Hospital, Helsinki University Central Hospital and University of Helsinki; O. Mäkitie, MD, PhD, Folkhälsan Research Center, and Children's Hospital, Helsinki University Central Hospital and University of Helsinki.
authors.forename: Outi
authors.initials: O
authors.lastname: Mäkitie
mesh_terms: D054392:Adipokines / Q000097:blood; D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D001171:Arthritis, Juvenile / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D024042:Collagen Type I / Q000097:blood*; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D012720:Severity of Illness Index
chemical_list: D054392:Adipokines; D052242:Adiponectin; D015415:Biomarkers; D024042:Collagen Type I; D020738:Leptin; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C047202:procollagen Type I N-terminal peptide
keywords: ADIPOKINES; ADIPONECTIN; BONE TURNOVER MARKERS; FAT MASS; JUVENILE IDIOPATHIC ARTHRITIS; LEPTIN