title: Factors influencing the outcome of infectious bronchitis vaccination and challenge experiments.
abstract: The factors influencing the outcome of infectious bronchitis vaccination and challenge experiments regarding the respiratory and renal systems are reviewed. Advantages and disadvantages of the available techniques for measuring protection against an infectious bronchitis virus challenge are discussed, including the definition of protection itself. Suggestions are made regarding some ways in which progress towards standardization of a recognized protocol for performing experimental challenge studies can be made and areas where more work is needed are indicated.
authors.affiliation: a GD (Animal Health Service) , Deventer , the Netherlands.
authors.forename: J J Sjaak
authors.initials: JJ
authors.lastname: de Wit
authors.forename: Jane K A
authors.initials: JK
authors.lastname: Cook
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002645:Chickens; D018352:Coronavirus Infections / Q000517:prevention & control* / Q000821:virology; D001351:Infectious bronchitis virus / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control* / Q000821:virology; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines