title: Academic College of Emergency Experts in India's INDO-US Joint Working Group and OPUS12 Foundation Consensus Statement on Creating A Coordinated, Multi-Disciplinary, Patient-Centered, Global Point-of-Care Biomarker Discovery Network.
abstract: Biomarker science brings great promise to clinical medicine. This is especially true in the era of technology miniaturization, rapid dissemination of knowledge, and point-of-care (POC) implementation of novel diagnostics. Despite this tremendous progress, the journey from a candidate biomarker to a scientifically validated biomarker continues to be an arduous one. In addition to substantial financial resources, biomarker research requires considerable expertise and a multidisciplinary approach. Investigational designs must also be taken into account, with the randomized controlled trial remaining the "gold standard". The authors present a condensed overview of biomarker science and associated investigational methods, followed by specific examples from clinical areas where biomarker development and/or implementation resulted in tangible enhancements in patient care. This manuscript also serves as a call to arms for the establishment of a truly global, well-coordinated infrastructure dedicated to biomarker research and development, with focus on delivery of the latest discoveries directly to the patient via point-of-care technology.
authors.affiliation: Department of Research and Innovation, Research Institute, Bethlehem, Pennsylvania ; Department of Research and Innovation, OPUS 12 Foundation Global, Columbus, USA.
authors.forename: Stanislaw P
authors.initials: SP
authors.lastname: Stawicki
authors.affiliation: Department of Research and Innovation, Research Institute, Bethlehem, Pennsylvania ; Department of Research and Innovation, Research Institute, Bethlehem, Pennsylvania.
authors.forename: Jill C
authors.initials: JC
authors.lastname: Stoltzfus
authors.affiliation: Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Praveen
authors.initials: P
authors.lastname: Aggarwal
authors.affiliation: Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Bhoi
authors.affiliation: Department of Anesthesiology, University of Toledo, College of Medicine, Toledo, USA.
authors.forename: Shashi
authors.initials: S
authors.lastname: Bhatt
authors.affiliation: Department of Medicine, University College of Medical Sciences, New Delhi, India.
authors.forename: O P
authors.initials: OP
authors.lastname: Kalra
authors.affiliation: Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Bhalla
authors.affiliation: Department of Research and Innovation, OPUS 12 Foundation Global, Columbus, USA ; Department of Surgery, St Luke's University Health Network, Bethlehem, Pennsylvania.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Hoey
authors.affiliation: Department of Research and Innovation, OPUS 12 Foundation Global, Columbus, USA ; Department of Emergency Medicine, University of Florida and Winter Haven Hospital, Florida, USA.
authors.forename: Sagar C
authors.initials: SC
authors.lastname: Galwankar
authors.affiliation: Department of Emergency Medicine, SUNY Downstate Medical Center, Long Island College Hospital, New York, USA.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Paladino
authors.affiliation: Department of Research and Innovation, OPUS 12 Foundation Global, Columbus, USA ; Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Papadimos
keywords: Biomarker research; global approach; patient-centered approach; point-of-care testing