title: Association between radiation pneumonitis and tumor response in patients with NSCLC treated with chemoradiation.
abstract: Dang and colleagues recently reported in the journal that tumor response to definitive chemoradiation, as assessed using the RECIST criteria, and the risk of radiation pneumonitis were positively correlated in patients with non-small cell lung cancer (NSCLC). We had previously reported similar findings in a study that used positron tomography both to measure tumor response and to assess normal tissue toxicity in patients treated with chemoradiation for NSCLC. Taken together these reports suggest that radiosensitivity of normal tissues and tumors may be strongly linked in a proportion of patients with lung cancer.
authors.affiliation: Departments of Radiation Oncology 1 and Molecular Imaging 2, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic 3002, Australia. michael.macmanus@petermac.org.
authors.forename: Michael P
authors.initials: MP
authors.lastname: MacManus
authors.forename: David
authors.initials: D
authors.lastname: Ball
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Hicks
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D017564:Radiation Pneumonitis / Q000175:diagnosis* / Q000209:etiology*; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*