title: The association between prostate cancer and mood disorders: a nationwide population-based study in Taiwan.
abstract: BACKGROUND
  This study identified possible risk factors for newly diagnosed mood disorders, including depressive and bipolar disorders, in prostate cancer patients.
  
  
  METHODS
  From 2000 to 2006, two cohorts were evaluated on the occurrence of mood disorder diagnosis and treatment. For the first cohort, data of patients diagnosed with prostate cancer was obtained from the Taiwan National Health Insurance (NHI) Research Database. As the second cohort, a cancer-free comparison group was matched for age, comorbidities, geographic region, and socioeconomic status.
  
  
  RESULTS
  Final analyses involved 12,872 men with prostate cancer and 12,872 matched patients. Increased incidence of both depressive (IRR 1.52, 95% CI 1.30-1.79, P <0.001) and bipolar disorder (IRR 1.84, 95% CI 1.25-2.74, P = 0.001) was observed among patients diagnosed with prostate cancer. Multivariate matched regression models show that cerebrovascular disease (CVD) and radiotherapy treatment could be independent risk factors for developing subsequent depressive and bipolar disorders.
  
  
  CONCLUSIONS
  We observed that the risk of developing newly diagnosed depressive and bipolar disorders is higher among Taiwanese prostate cancer patients. Clinicians should be aware of the possibility of increased depressive and bipolar disorders among prostate cancer patients in Taiwan. A prospective study is necessary to confirm these findings.
authors.affiliation: Department of Psychiatry,Yuanshan Branch,Taipei Veterans General Hospital,Yilan,Taiwan.
authors.forename: Pan-Ming
authors.initials: PM
authors.lastname: Chen
authors.affiliation: Division of Hematology and Oncology,Department of Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: San-Chi
authors.initials: SC
authors.lastname: Chen
authors.affiliation: Division of Hematology and Oncology,Department of Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Chia-Jen
authors.initials: CJ
authors.lastname: Liu
authors.affiliation: Division of Hematology and Oncology,Department of Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Man-Hsin
authors.initials: MH
authors.lastname: Hung
authors.affiliation: Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Chia-Fen
authors.initials: CF
authors.lastname: Tsai
authors.affiliation: Cancer Center,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hu
authors.affiliation: Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Mu-Hong
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Department of Psychiatry,Chiayi Branch,Taichung Veterans General Hospital,Chiayi,Taiwan.
authors.forename: Cheng-Che
authors.initials: CC
authors.lastname: Shen
authors.affiliation: Department of Psychiatry,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.affiliation: Department of Family Medicine,Taipei Veterans General Hospital,Taipei,Taiwan.
authors.forename: Chiu-Mei
authors.initials: CM
authors.lastname: Yeh
authors.affiliation: Department of Psychiatry,Kaohsiung Veterans General Veterans Hospital,Kaohsiung City,Taiwan.
authors.forename: Ti
authors.initials: T
authors.lastname: Lu
authors.affiliation: School of Medicine,National Yang-Ming University,Taipei,Taiwan.
authors.forename: Tzeng-Ji
authors.initials: TJ
authors.lastname: Chen
authors.affiliation: Department of Psychiatry,Kaohsiung Veterans General Veterans Hospital,Kaohsiung City,Taiwan.
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D001714:Bipolar Disorder / Q000453:epidemiology*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012044:Regression Analysis; D012074:Remission Induction; D012189:Retrospective Studies; D012307:Risk Factors; D012923:Social Class; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
keywords: epidemiology