title: Remote conformational control of a molecular switch via methylation and deprotonation.
abstract: Exacting control over conformation in response to an external stimulus is the central focus of molecular switching. Here we describe the synthesis of a series of diphenylacetylene-based molecular switches, and examine their response to covalent modification and deprotonation at remote phenolic positions. A complex interplay between multiple intramolecular hydrogen bond donors and acceptors determines the global conformation.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK. sam.thompson@chem.ox.ac.uk andrew.hamilton@chem.ox.ac.uk.
authors.forename: Peter C
authors.initials: PC
authors.lastname: Knipe
authors.forename: Ian M
authors.initials: IM
authors.lastname: Jones
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D006860:Hydrogen Bonding; D008745:Methylation; D008958:Models, Molecular; D008968:Molecular Conformation; D011522:Protons; D013816:Thermodynamics
chemical_list: D011522:Protons; C044735:biphenylacetylene; D000114:Acetylene