title: Prognostic value of caveolin-1 expression in gastric cancer: a meta-analysis.
abstract: The relationship between caveolin-1 (Cav-1) and clinicopathological characteristics of gastric cancer is controversial, although Cav-1 plays an important role in tumor metastasis. To evaluate the clinicopathological and prognostic value of expression in patients with gastric cancer, a meta-analysis was performed to investigate the impact on clinicopathological parameters and prognosis in gastric cancer cases. Studies assessing these parameters for Cav-1 in gastric cancer were identified up to June 2014. Finally, a total of six studies met the inclusion criteria. Our combined results showed that Cav-1 expression was significantly associated with the Lauren classification (pooled OR=0.603, 95% CI: 0.381-0.953, P=0.030). Furthermore, we found that Cav-1 expression predicted a better overall survival in gastric cancer patients (pooled OR=0.590, 95% CI: 0.360-0.970, P=0.038, fixed-effect). In conclusion, the overall data of the present meta analysis showed that Cav-1 expression was not correlated with clinicopathological features except for the Lauren classification. Simultaneously, Cav-1 overexpression predicted a better overall survival in gastric cancer. Cav-1 expression in tumors is a candidate positive prognostic biomarker for gastric cancer patients.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Jiangsu University, Nanjing, China E-mail : jamesnone@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Ye
authors.forename: Shu-Han
authors.initials: SH
authors.lastname: Miao
authors.forename: Rong-Zhu
authors.initials: RZ
authors.lastname: Lu
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Zhou
mesh_terms: D016022:Case-Control Studies; D051242:Caveolin 1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1