title: Lack of family-based association between common variations in WNK1 and blood pressure level.
abstract: BACKGROUND
  WNK1 (With No-lysine Kinase 1) modulates numerous sodium transport-related ion channels involved in regulation of blood pressure. Several studies have indicated associations between the common variants of the WNK1 gene and hypertension or blood pressure levels. However, little data exists on Asian populations and normotensive or pre-hypertensive subjects. Our aim was to detect whether the common variations in the WNK1 gene are potential contributors to individual variations in blood pressure in a family-based sample.
  
  
  METHODS
  525 individuals from 116 families were selected from a rural community of Northern China. Five single-nucleotide polymorphisms were selected from the WNK1 gene. Single-marker and haplotype analyses were conducted using the Family-Based Association Test program.
  
  
  RESULTS
  Regretful, no associations for the 5 WNK1 SNPs and the constructed haplotype blocks of WNK1 with blood pressure level reached nominal statistical significance.
  
  
  CONCLUSIONS
  We conclude that although multiple candidate genes are involved in development of hypertension, the genetic polymorphism in WNK1 is not a major contributor to the observed variability in blood pressure and familial clustering risk of hypertension.
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Qiufang
authors.initials: Q
authors.lastname: Lian
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Keyu
authors.initials: K
authors.lastname: Ren
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Chao
authors.initials: C
authors.lastname: Chu
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Tongshuai
authors.initials: T
authors.lastname: Guo
authors.affiliation: Laboratory Animal Center, Xi'an Jiaotong University School of Medicine, Xi'an, China (mainland).
authors.forename: Enqi
authors.initials: E
authors.lastname: Liu
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Jianjun
authors.initials: J
authors.lastname: Mu
authors.affiliation: Department of Cardiovascular, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China (mainland).
authors.forename: Zuyi
authors.initials: Z
authors.lastname: Yuan
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000235:genetics*; D002681:China; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000076204:WNK Lysine-Deficient Protein Kinase 1; D055815:Young Adult
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015778:Minor Histocompatibility Antigens; D017346:Protein Serine-Threonine Kinases; D000076204:WNK Lysine-Deficient Protein Kinase 1; C498743:WNK1 protein, human