title: Two-photon excitation of porphyrin-functionalized porous silicon nanoparticles for photodynamic therapy.
abstract: Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
authors.affiliation: Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296, Montpellier, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Secret
authors.forename: Marie
authors.initials: M
authors.lastname: Maynadier
authors.forename: Audrey
authors.initials: A
authors.lastname: Gallud
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chaix
authors.forename: Elise
authors.initials: E
authors.lastname: Bouffard
authors.forename: Magali
authors.initials: M
authors.lastname: Gary-Bobo
authors.forename: Nathalie
authors.initials: N
authors.lastname: Marcotte
authors.forename: Olivier
authors.initials: O
authors.lastname: Mongin
authors.forename: Khaled
authors.initials: K
authors.lastname: El Cheikh
authors.forename: Vincent
authors.initials: V
authors.lastname: Hugues
authors.forename: Mélanie
authors.initials: M
authors.lastname: Auffan
authors.forename: Céline
authors.initials: C
authors.lastname: Frochot
authors.forename: Alain
authors.initials: A
authors.lastname: Morère
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
authors.forename: Mireille
authors.initials: M
authors.lastname: Blanchard-Desce
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Sailor
authors.forename: Marcel
authors.initials: M
authors.lastname: Garcia
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Durand
authors.forename: Frédérique
authors.initials: F
authors.lastname: Cunin
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D004705:Endocytosis / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D007259:Infrared Rays; D061986:MCF-7 Cells; D008358:Mannose / Q000737:chemistry / Q000627:therapeutic use; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D010778:Photochemotherapy / Q000379:methods*; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D016062:Porosity; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use*; D012825:Silicon / Q000737:chemistry / Q000627:therapeutic use*
chemical_list: D001672:Biocompatible Materials; D017319:Photosensitizing Agents; D011166:Porphyrins; D008358:Mannose; D012825:Silicon
keywords: mannose; nanoparticle; photodynamic therapy; porous silicon; two-photon excitation