title: Adenoid cystic carcinoma of the breast: report of two cases with immunohistochemical profile of C-kit and MYB overexpression.
abstract: Adenoid cystic carcinoma (ACC) is a rare tumor with characteristic histologic features. Staining with basal markers for estrogen receptor, progesterone receptor, and HER2 usually shows negative results. Immunohistochemical analysis of C-kit and MYB overexpression of the ACC also has been reported. We report two cases of ACC of the breast with C-kit and MYB overexpression that clinically confirm these previously reported characteristics and suggest that further molecular study of the expression of these two proteins can lead to future therapeutic strategies.
authors.affiliation: Department of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea.
authors.forename: Susie
authors.initials: S
authors.lastname: Chin
authors.forename: Zisun
authors.initials: Z
authors.lastname: Kim
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor; D001940:Breast / Q000473:pathology; D015820:Cadherins / Q000096:biosynthesis; D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D015412:Mastectomy, Segmental; D008875:Middle Aged; D020626:Oncogene Proteins v-myb / Q000096:biosynthesis*; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis*; D064726:Triple Negative Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D020626:Oncogene Proteins v-myb; D004317:Doxorubicin; D003520:Cyclophosphamide; D019009:Proto-Oncogene Proteins c-kit; D005472:Fluorouracil