title: Effects of chromium methionine supplementation on growth performance, serum metabolites, endocrine parameters, antioxidant status, and immune traits in growing pigs.
abstract: The effects of dietary chromium methionine (CrMet) on growth performance, serum metabolites, endocrine parameters, antioxidant status, and immune traits in growing pigs were investigated. A total of 180 crossbred pigs (30.18 ± 0.28 kg initial body mass) were randomly divided into five groups, each group with six pens, six pigs per pen. Pigs were fed on the same basal diet supplemented with 0 (control), 100, 200, 400, and 800 μg/kg Cr from CrMet for 35 days. The results showed that supplemental CrMet did not affect growth performance. Cr at 200-800 μg/kg significantly decreased serum glucose levels (P < 0.05), while other serum metabolites were unaffected by Cr supplementation. Serum growth hormone (GH) levels were significantly decreased by Cr addition (P < 0.05). Furthermore, serum insulin-like growth factor I (IGF-I) levels were linearly decreased with increased Cr dose, and a significant reduction was observed in pigs fed 800 μg/kg Cr diets (P < 0.05). Serum immunoglobulin A, G, and M concentrations were increased linearly with increased Cr dosage, and pigs fed 400 μg/kg Cr had greater serum immunoglobulin M contents (P < 0.05). Cr at 400 μg/kg significantly increased serum superoxide dismutase and total antioxidant capacity activities (T-AOC) (P < 0.05). However, Cr at 800 μg/kg increased serum catalase activities, while decreasing serum T-AOC contents (P < 0.05). Additionally, there was a significant increase in serum malondialdehyde levels for pigs fed 800 μg/kg Cr diets (P < 0.05). These results indicated that dietary supplementation CrMet decreased serum glucose, GH, and IGF-I levels. Besides, supplemental 400 μg/kg Cr as CrMet improved serum antioxidant status and immune responses, but additional 800 μg/kg Cr resulted in lipid peroxidation in growing pigs.
authors.affiliation: State Key Laboratory of Animal Nutrition, Ministry of Agriculture Feed Industry Centre, China Agricultural University, Beijing, 100193, China.
authors.forename: Yao-Yao
authors.initials: YY
authors.lastname: Tian
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Dong
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Jian-Xiang
authors.initials: JX
authors.lastname: Xue
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Gong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002857:Chromium / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D008715:Methionine / Q000494:pharmacology*; D013552:Swine
chemical_list: D000975:Antioxidants; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D002857:Chromium; D008315:Malondialdehyde; D008715:Methionine