title: Where to begin? Mapping transcription start sites genome-wide in Escherichia coli.
abstract: Recent genome-wide studies of bacterial transcription have revealed large numbers of promoters located inside genes. In this issue of the Journal of Bacteriology, Thomason and colleagues (J. Bacteriol. 197:18-28, 2015, doi:10.1128/JB.02096-14) map transcription start sites in Escherichia coli on an unprecedented scale. This work provides important insights into the regulation of transcripts that initiate inside genes and sources of variability between studies aimed at identifying these RNAs.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, New York, USA Department of Biomedical Sciences, University at Albany, Albany, New York, USA joseph.wade@health.ny.gov.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Wade
mesh_terms: D004926:Escherichia coli / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D016372:RNA, Antisense / Q000378:metabolism*; D012329:RNA, Bacterial / Q000378:metabolism*; D024363:Transcription Initiation Site / Q000502:physiology*
chemical_list: D016372:RNA, Antisense; D012329:RNA, Bacterial