title: Acquired pure red cell aplasia in a patient of rheumatoid arthritis.
abstract: Pure red cell aplasia (PRCA) is characterized as a normocytic anemia associated with reticulocytopenia and the absence of erythroblasts in the bone marrow. PRCA can be induced by various causes such as thymoma, connective tissue disease, viral infection, lymphoma, and adverse drug reactions. There have been only a few reports of PRCA associated with rheumatoid arthritis (RA). We report a 45 year old female presented with symptomatic anemia of several months duration on a background of long standing seropositive deforming RA. Bone marrow examination revealed marked suppression of erythroid precursors with normal myeloid and megakaryocytic series, thereby confirming PRCA. Anemia improved following therapy with prednisolone 1 mg/kg/day. This article also reviews the current status of therapy in acquired PRCA.
authors.affiliation: Department of Medical and Pediatric Oncology, Gujarat Cancer and Research Institute (GCRI), Asarwa, Ahmedabad, 380016 India.
authors.forename: Prasant Kumar
authors.initials: PK
authors.lastname: Parida
authors.affiliation: Department of Medical and Pediatric Oncology, Gujarat Cancer and Research Institute (GCRI), Asarwa, Ahmedabad, 380016 India.
authors.forename: Shilin N
authors.initials: SN
authors.lastname: Shukla
authors.affiliation: Department of Medical and Pediatric Oncology, Gujarat Cancer and Research Institute (GCRI), Asarwa, Ahmedabad, 380016 India.
authors.forename: Shailesh S
authors.initials: SS
authors.lastname: Talati
authors.affiliation: Department of Medical and Pediatric Oncology, Gujarat Cancer and Research Institute (GCRI), Asarwa, Ahmedabad, 380016 India.
authors.forename: Sonia K
authors.initials: SK
authors.lastname: Parikh
keywords: Corticosteroids (CS); Normocytic anemia; Pure red cell aplasia (PRCA); Rheumatoid arthritis (RA); Thymoma