title: [The expression and significance of chemokines eotaxin and RANTES in the rat model of allergic rhinitis].
abstract: OBJECTIVE
  To explore the expression and significance of Eotaxin and RANTES in the rat model of allergic rhinitis (AR).
  
  
  METHODS
  20 female SD rats in 6-7 weeks were randomly divided into control group and AR group (n = 10, respectively). AR rat model was made with ovalbumin stimulation. To detect pathological changes in mucosa and chemokine Eotaxin, RANTES in their nasal and lung tissues after execution.
  
  
  RESULTS
  Compared with the control group, Lung EOS cell counted higher in AR group and the difference was significant (P < 0.01); the AR rats nasal mucosa and lung tissue of Eotaxin, RANTES expression was significantly increased (P < 0.01).
  
  
  CONCLUSIONS
  There exist high expression of Eotaxin, RANTES, infiltration of eosinophils in nasal and lung tissue of model rats with allergic rhinitis, inferring that the upper and lower respiratory tract inflammatory response has obvious consistency.
authors.forename: Cuiling
authors.initials: C
authors.lastname: Tian
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Lei
authors.forename: Minhong
authors.initials: M
authors.lastname: Shui
authors.forename: Yanhong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qianwei
authors.initials: Q
authors.lastname: Jia
authors.forename: Jing
authors.initials: J
authors.lastname: Tu
authors.forename: Gang
authors.initials: G
authors.lastname: Lian
authors.forename: Siquan
authors.initials: S
authors.lastname: Tang
mesh_terms: D000818:Animals; D054413:Chemokine CCL11 / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D008168:Lung / Q000378:metabolism; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D065631:Rhinitis, Allergic / Q000378:metabolism*
chemical_list: C515458:Ccl11 protein, rat; D054413:Chemokine CCL11; D018946:Chemokine CCL5