title: Isolation, identification and characterization of related substances in furbenicillin.
abstract: Furbenicillin is a broad-spectrum semisynthetic penicillin with strong antibacterial activity against Gram-negative bacteria. In this study, three impurities in furbenicillin, including an unknown epimer, were determined. On the basis of a complete analysis of the spectrum (MS, (1)H,(13)C, 2D NMR and CD) and the results of chemical methods, the unknown epimer impurity was identified as 10-epi-furbenicillin (impurity 1). Isolation and structure elucidation of impurity 1 was also reported here for the first time.
authors.affiliation: National Institute for Food and Drug Control, Beijing, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: National Institute for Food and Drug Control, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Chang
authors.affiliation: National Institute for Food and Drug Control, Beijing, China.
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Feng
authors.affiliation: National Institute for Food and Drug Control, Beijing, China.
authors.forename: Dou-Sheng
authors.initials: DS
authors.lastname: Zhang
authors.affiliation: National Institute for Food and Drug Control, Beijing, China.
authors.forename: Changqin
authors.initials: C
authors.lastname: Hu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002942:Circular Dichroism; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010406:Penicillins / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; C019401:furbenicillin