title: Cobalt-catalyzed enantioselective hydroboration of 1,1-disubstituted aryl alkenes.
abstract: We report the synthesis of cobalt complexes of novel iminopyridine-oxazoline (IPO) ligands and their application to the asymmetric hydroboration of 1,1-disubstituted aryl alkenes. The new catalysts afforded α-alkyl-β-pinacolatoboranes with exclusive regioselectivity in high yields with up to 99.5% ee. Furthermore, we have applied this method to an efficient synthesis of naproxen.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Ziqing
authors.initials: Z
authors.lastname: Zuo
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Wan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang