title: Solid-phase extraction based on chloromethylated polystyrene magnetic nanospheres followed by gas chromatography with mass spectrometry to determine phthalate esters in beverages.
abstract: An ultrasound-assisted magnetic solid-phase extraction procedure with chloromethylated polystyrene-coated Fe3 O4 nanospheres as magnetic adsorbents has been developed to determine eight phthalate esters (bis(4-methyl-2-pentyl) phthalate, dipentyl phthalate, dihexyl phthalate, benzyl butyl phthalate, bis(2-butoxyethyl) phthalate, dicyclohexyl phthalate, di-n-octyl phthalate, and dinonyl phthalate) simultaneously in beverage samples, in combination with gas chromatography coupled to tandem mass spectrometry for the first time. Several factors related to magnetic solid-phase extraction efficiencies, such as amount of adsorbent, extracting time, ionic strength, and desorption conditions were investigated. The enrichment factors of the method for the eight analytes were over 2482. A good linearity was observed in the range of 10-500 ng/L for bis(2-butoxyethyl) phthalate and 2-500 ng/L for the other phthalate esters with correlation coefficients ranging from 0.9980 to 0.9998. The limits of detection and quantification for the eight phthalate esters were in the range of 0.20-2.90 and 0.67-9.67 ng/L, respectively. The mean recoveries at three spiked levels were 75.8-117.7%, the coefficients of variations were <11.6%. The proposed method was demonstrated to be a simple and efficient technique for the trace analysis of the phthalate esters in beverage samples.
authors.affiliation: Research Center of Analysis and Measurement, Zhejiang University of Technology, Hangzhou, Zhejiang, P.R. China.
authors.forename: Xiaoji
authors.initials: X
authors.lastname: Cao
authors.forename: Qiaoling
authors.initials: Q
authors.lastname: Kong
authors.forename: Ruonan
authors.initials: R
authors.lastname: Cai
authors.forename: Kundan
authors.initials: K
authors.lastname: Zhu
authors.forename: Xuemin
authors.initials: X
authors.lastname: Ye
authors.forename: Jiaoyu
authors.initials: J
authors.lastname: Chen
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
authors.forename: Jianli
authors.initials: J
authors.lastname: Wang
mesh_terms: D001628:Beverages / Q000032:analysis*; D004952:Esters / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006843:Hydrocarbons, Chlorinated / Q000737:chemistry; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry; D010795:Phthalic Acids / Q000032:analysis*; D011137:Polystyrenes / Q000737:chemistry*; D052616:Solid Phase Extraction
chemical_list: D004952:Esters; D006843:Hydrocarbons, Chlorinated; D058185:Magnetite Nanoparticles; D010795:Phthalic Acids; D011137:Polystyrenes
keywords: Gas chromatography; Magnetic nanospheres; Phthalate esters; Solid-phase extraction; Tandem mass spectrometry