title: [Current antibiotic resistance profile of uropathogenic Escherichia coli strains and therapeutic consequences].
abstract: Urinary tract infections (UTI) are a very common reason for consultation and prescription in current practice. Excessive or inappropriate use of antibiotics in treating urinary tract infections is responsible for the emergence and spread of multiresistant uropathogenic bacteria.
  
  
  OBJECTIVE
  To evaluate the isolation frequency and antibiotic resistance of uropathogenic Escherichia coli strains isolated at the Marrakech region.
  
  
  METHODS
  We conducted a retrospective study over a period of three years (from 1st January 2010 to 31 December 2012). It included all non-redundant uropathogenic E. coli strains isolated in the microbiology laboratory of the Avicenne hospital of Marrakech, Morocco.
  
  
  RESULTS
  During this study, 1472 uropathogenic enterobacteriaceae were isolated including 924 non-repetitive E. coli strains, an overall isolation frequency of 63%. Antibiotic resistance of isolated E. coli strains showed resistance rates to amoxicillin (65%), sulfamethoxazole-triméthropime (55%), amoxicillin-clavulanic acid (43%), ciprofloxacin (22%), gentamicin (14%), nitrofurans (11%), amikacin (8%) and fosfomycin (7%). The number of E. coli strains resistant to C3G by ESBL production was 67, an average frequency of 4.5% of all isolated uropathogenic enterobacteria. The associated antibiotic resistance in the case of ESBL-producing E. coli were 82% for ciprofloxacin, 76% for sulfamethozole trimethoprim, 66% for gentamicin and 56% for amikacin. No resistance to imipenem was recorded for the isolated E. coli strains, which represents an imipenem sensitivity of 100%.
  
  
  CONCLUSIONS
  Antibiotic resistance of uropathogenic E. coli strains limits treatment options and therefore constitutes a real public health problem. The regular updating of antibiotic susceptibility statistics of E. coli strains allows a better adaptation of the probabilistic antibiotic therapy to local epidemiological data.
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Mohammed V. Souissi, Rabat, Maroc. Electronic address: medbouamri1@gmail.com.
authors.forename: M C
authors.initials: MC
authors.lastname: El Bouamri
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Cadi Ayyad, Marrakech, Maroc.
authors.forename: L
authors.initials: L
authors.lastname: Arsalane
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Cadi Ayyad, Marrakech, Maroc.
authors.forename: Y
authors.initials: Y
authors.lastname: Kamouni
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Cadi Ayyad, Marrakech, Maroc.
authors.forename: H
authors.initials: H
authors.lastname: Yahyaoui
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc.
authors.forename: N
authors.initials: N
authors.lastname: Bennouar
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Mohammed V. Souissi, Rabat, Maroc.
authors.forename: M
authors.initials: M
authors.lastname: Berraha
authors.affiliation: Laboratoire de bactériologie et virologie, hôpital militaire et universitaire Avicenne de Marrakech, Marrakech, Maroc; Faculté de médecine et de pharmacie, université Mohammed V. Souissi, Rabat, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Zouhair
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D009018:Morocco / Q000453:epidemiology; D015995:Prevalence; D012189:Retrospective Studies; D017211:Treatment Failure; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D056689:Uropathogenic Escherichia coli / Q000302:isolation & purification*; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: Antibiotics; Antibiotiques; E. coli; Entérobactéries; Extended-spectrum β-lactamase; Resistance; Résistance; β-lactamases à spectre étendu