title: Diastereo- and enantioselective propargylation of benzofuranones catalyzed by pybox-copper complex.
abstract: Diastereo- and enantioselective preparation of 2,2-disubstituted benzofuran-3(2H)-one has been realized by a pybox-copper catalyzed reaction between 2-substituted benzofuran-3(2H)-one and propargyl acetate. The utility of this method was demonstrated by further transformation of the terminal alkyne into a methyl ketone without loss of enantiomeric purity.
authors.affiliation: Department of Chemistry, College of Sciences, Shanghai University , 99 Shangda Road, Shanghai 200444, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhao
authors.forename: Guanxin
authors.initials: G
authors.lastname: Huang
authors.forename: Beibei
authors.initials: B
authors.lastname: Guo
authors.forename: Lijun
authors.initials: L
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cao
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001572:Benzofurans; D007659:Ketones; D003300:Copper; D010293:Pargyline