title: A bioactive molecule in a complex wound healing process: platelet-derived growth factor.
abstract: Wound healing is considered to be particularly important after surgical procedures, and the most important wounds related to surgical procedures are incisional, excisional, and punch wounds. Research is ongoing to identify methods to heal non-closed wounds or to accelerate wound healing; however, wound healing is a complex process that includes many biological and physiological events, and it is affected by various local and systemic factors, including diabetes mellitus, infection, ischemia, and aging. Different cell types (such as platelets, macrophages, and neutrophils) release growth factors during the healing process, and platelet-derived growth factor is a particularly important mediator in most stages of wound healing. This review explores the relationship between platelet-derived growth factor and wound healing.
authors.affiliation: Espiye Vocational School, Giresun University, Giresun, Turkey.
authors.forename: Kaan
authors.initials: K
authors.lastname: Kaltalioglu
authors.affiliation: Biology Department, Science Faculty, Gazi University, Ankara, Turkey.
authors.forename: Sule
authors.initials: S
authors.lastname: Coskun-Cevher
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D002921:Cicatrix / Q000378:metabolism; D005347:Fibroblasts / Q000502:physiology*; D006097:Granulation Tissue / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018919:Neovascularization, Physiologic; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D014945:Wound Healing
chemical_list: D010982:Platelet-Derived Growth Factor