title: Brain atrophy in radiologically isolated syndromes.
abstract: BACKGROUND
  The aim of this study was to compare brain atrophy in radiologically isolated syndrome (RIS), in clinically isolated syndrome (CIS), and in individuals with subjective complaints (ISC).
  
  
  METHODS
  Patients with RIS were included prospectively during June 2009 to June 2012. CIS patients and ISC were used to compare the RIS sample. An automated analysis tool, SIENAX, was used to obtain normalized total brain volume (NTBV), normalized cortical volume (NCV), and normalized white matter volume (NWMV). ANOVA test was used to analyze the data.
  
  
  RESULTS
  A total of 10 RIS patients, 43 CIS patients, and 29 ISC were included. The NTBV in RIS was 1.56 mm(3) × 10(6) , 1.52 × 10(6) in CIS, and 1.64 × 10(6) in ISC (P = .12 vs. CIS and P = .003 vs. ISC); the NCV in RIS was .59 × 10(6) , .55 × 10(6) in CIS, and .71 × 10(6) in ISC (P = .22 vs. CIS and P = .002 vs. ISC), and NWMV in RIS was 1.1 × 10(6) , 1 in CIS and 1.12 × 10(6) in ISC (P = .66 vs. CIS and P = .12 vs.
  NTBV and NCV were significantly lower in RIS compared with ISC while no differences were observed in NWMV.
authors.affiliation: Multiple Sclerosis Center of Buenos Aires (CEMBA), Neurology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Juan Ignacio
authors.initials: JI
authors.lastname: Rojas
authors.forename: Liliana
authors.initials: L
authors.lastname: Patrucco
authors.forename: Jimena
authors.initials: J
authors.lastname: Míguez
authors.forename: Cristina
authors.initials: C
authors.lastname: Besada
authors.forename: Edgardo
authors.initials: E
authors.lastname: Cristiano
mesh_terms: D000328:Adult; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009929:Organ Size; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013577:Syndrome
keywords: Radiologically isolated syndrome; magnetic resonance imaging; multiple sclerosis