title: Application of Paper Strip Extraction in Combination with LC-MS-MS in Pharmacokinetics.
abstract: Recent advances in sampling techniques in the pharmaceutical industry sparked significant interest in applying improvements to extraction methods for greater analyte detection and quantitation. In particular, the dried blood spot (DBS) sampling technique has numerous advantages compared to traditional methods such as liquid-liquid extraction, including the use of small sample volumes, less sample processing, and less exposure to toxic solvents (ether, methyltert-butyl ether [MTBE], and dichloromethane). In this article, we discuss the adaptation of DBS technology to develop and validate a novel paper strip extraction method for the analysis of natural product metabolites in biological samples obtained from a human pharmacokinetic study of xanthohumol, a hop prenylflavonoid.
authors.affiliation: Linus Pauling Institute and the College of Pharmacy at Oregon State University in Corvallis, Oregon.
authors.forename: LeeCole L
authors.initials: LL
authors.lastname: Legette
authors.affiliation: Linus Pauling Institute and the College of Pharmacy at Oregon State University in Corvallis, Oregon.
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Reed
authors.affiliation: College of Pharmacy at Oregon State University.
authors.forename: Lia
authors.initials: L
authors.lastname: Murty
authors.affiliation: Department of Chemistry at Oregon State University.
authors.forename: Claudia S
authors.initials: CS
authors.lastname: Maier
authors.affiliation: Linus Pauling Institute and the College of Pharmacy at Oregon State University in Corvallis, Oregon.
authors.forename: Jan F
authors.initials: JF
authors.lastname: Stevens