title: Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.
abstract: Calcium-mediated signals play important roles in epidermal barrier formation, skin homoeostasis and wound repair. Calmodulin 4 (Calm4) is a small, Ca2+ -binding protein with strong expression in suprabasal keratinocytes. In mice, Calm4 first appears in the skin at the time of barrier formation, and its expression increases in response to epidermal barrier challenges. In this study, we report the generation of Calm4 knockout mice and provide evidence that Calm4 is dispensable for epidermal barrier formation, maintenance and repair.
authors.affiliation: Laboratory of Skin Biology, National Institute for Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
authors.forename: Juliane C
authors.initials: JC
authors.lastname: Lessard
authors.forename: Alexandr
authors.initials: A
authors.lastname: Kalinin
authors.forename: Paul W
authors.initials: PW
authors.lastname: Bible
authors.forename: Maria I
authors.initials: MI
authors.lastname: Morasso
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000737:chemistry; D002147:Calmodulin / Q000235:genetics / Q000502:physiology*; D002154:Calpain / Q000235:genetics / Q000502:physiology*; D002465:Cell Movement; D004817:Epidermis / Q000378:metabolism*; D015603:Keratinocytes / Q000166:cytology; D007763:Lac Operon; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010641:Phenotype; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism; D014945:Wound Healing
chemical_list: D002135:Calcium-Binding Proteins; D002147:Calmodulin; C480164:Calm4 protein, mouse; D002154:Calpain
keywords: calcium-binding protein; epidermis; skin barrier; wound repair