title: Self-folded redox/acid dual-responsive nanocarriers for anticancer drug delivery.
abstract: Self-folded redox/acid dual-responsive nanocarriers (RAD-NCs) are developed for physiologically triggered delivery of anticancer drugs. The evidenced redox/acid responsiveness, facile decoration of ligands, and active tumor-targeting capability of RAD-NCs suggest their potential as a promising formulation for tumor-targeted chemotherapy.
authors.affiliation: Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA. zgu@email.unc.edu zgu3@ncsu.edu.
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.forename: Ran
authors.initials: R
authors.lastname: Mo
authors.forename: Wanyi
authors.initials: W
authors.lastname: Tai
authors.forename: Wujin
authors.initials: W
authors.lastname: Sun
authors.forename: Dennis B
authors.initials: DB
authors.lastname: Pacardo
authors.forename: Chenggen
authors.initials: C
authors.lastname: Qian
authors.forename: Qundong
authors.initials: Q
authors.lastname: Shen
authors.forename: Frances S
authors.initials: FS
authors.lastname: Ligler
authors.forename: Zhen
authors.initials: Z
authors.lastname: Gu
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry; D005978:Glutathione / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D010455:Peptides; C027794:polyserine; D011092:Polyethylene Glycols; D004317:Doxorubicin; D005492:Folic Acid; D005978:Glutathione