title: Serial changes of neointimal tissue after everolimus-eluting stent implantation in porcine coronary artery: an optical coherence tomography analysis.
abstract: OBJECTIVE
  The serial changes in neointimal tissues were compared between everolimus-eluting stent (EES) and bare-metal stent (BMS) in the porcine coronary artery using optical coherence tomography (OCT).
  
  
  METHODS
  Serial (1, 3, and 6 month follow-up after stent implantation) OCT examinations were performed in 15 swine with 15 BMS- and 15 EES-treated lesions in porcine coronary arteries.
  
  
  RESULTS
  In BMS-implanted lesions, neointimal volume decreased from 7.3 mm(3) to 6.9 mm(3) and 6.4 mm(3) at 1, 3, and 6 months follow-up without statistical significance (P = 0.369). At the time points of 1, 3, and 6 months, neointimal tissue appearance was mainly a homogeneous pattern (80.0%, 93.3%, and 100%, resp.), while the other pattern was layered. In contrast, in EES-implanted lesions, neointimal volume significantly increased from 4.8 mm(3) to 9.8 mm(3) between 1 and 3 months but significantly decreased to 8.6 mm(3) between 3 and 6 months (P < 0.001). Between 1 and 3 months, the layered pattern of neointimal tissue increased from 26.7% to 66.7% but decreased to 20.0% between 3 and 6 months.
  
  
  CONCLUSIONS
  EES had a biphasic pattern of neointimal amounts that correlated with changes in neointimal morphology.
authors.affiliation: Chung-Ang University Medical Center, 102 Heukseokro, Dongjak-gu, Seoul 156-755, Republic of Korea.
authors.forename: Hoyoun
authors.initials: H
authors.lastname: Won
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Jung-Sun
authors.initials: JS
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Shin
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Byeong-Keuk
authors.identifier: 0000-0003-2493-066X
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Young-Guk
authors.identifier: 0000-0001-7748-5788
authors.initials: YG
authors.lastname: Ko
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Donghoon
authors.initials: D
authors.lastname: Choi
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Severance Biomedical Science Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Cardiovascular Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea ; Severance Biomedical Science Institute, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-go, Seoul 120-752, Republic of Korea.
authors.forename: Myeong-Ki
authors.initials: MK
authors.lastname: Hong
mesh_terms: D000818:Animals; D001807:Blood Vessel Prosthesis; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000187:drug effects*; D054855:Drug-Eluting Stents; D000068338:Everolimus; D006965:Hyperplasia; D058426:Neointima / Q000188:drug therapy* / Q000473:pathology*; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D034421:Sus scrofa; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D000068338:Everolimus; D020123:Sirolimus