title: Targeting oncogenes and tumor suppressors genes to mitigate chemoresistance.
abstract: Malfunctions in membrane transporters or disruptions in signaling cascades induce resistance to chemotherapy in cancer cells resulting in treatment failure. To adjust the genetic alterations leading to these cellular protective measures, dissection and verification of the contributing routes would be required. In justification of knockdown of the key genes, RNA interference provides a reliable probing tool, enabling exploration of phenotypic manifestation of targeted genes. Investigation of the non-transporter targets, predominantly oncogenes and tumor suppressor genes, by means of small interfering RNA with the aim to re-sensitize cancer cells to therapeutics will be discussed in this review.
authors.forename: Tahereh
authors.initials: T
authors.lastname: Fatemian
authors.affiliation: Jeffrey Cheah School of Medicine and Health Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Malaysia. md.ezharul.hoque@monash.edu.
authors.forename: Ezharul Hoque
authors.initials: EH
authors.lastname: Chowdhury
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D016147:Genes, Tumor Suppressor / Q000187:drug effects*; D006801:Humans; D008954:Models, Biological; D058990:Molecular Targeted Therapy; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes / Q000187:drug effects*
chemical_list: D000970:Antineoplastic Agents