title: SiRNA gene therapy using albumin as a carrier.
abstract: RNA interference or post-transcriptional gene silencing is one of the latest, innovative, highly specific, and efficient technologies for gene therapy application in molecular oncology. It is already a well-established research tool for analyses of molecular mechanisms for various diseases including cancer as it efficiently silences the expression of genes of interest. However, for its proper therapeutic use, an efficient tumor-specific in-vivo delivery mechanism is essential. Many scientific groups and companies are involved in the development of efficient in-vivo delivery mechanisms for small interfering RNA, but are still struggling. The present article suggests utilization of albumin as a delivery module for small interfering RNA as it is an endogenous natural nanoparticle known for its binding properties to various endogenous metabolites, drugs, and metal ions.
authors.affiliation: Department of Biophysics, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Anshoo
authors.initials: A
authors.lastname: Malhotra
authors.forename: Bhagwant Rai
authors.initials: BR
authors.lastname: Mittal
mesh_terms: D000418:Albumins / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D015316:Genetic Therapy; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D034741:RNA, Small Interfering / Q000008:administration & dosage*
chemical_list: D000418:Albumins; D004337:Drug Carriers; D034741:RNA, Small Interfering