title: Biodegradable composite scaffolds of bioactive glass/chitosan/carboxymethyl cellulose for hemostatic and bone regeneration.
abstract: Hemostasis in orthopedic osteotomy or bone cutting requires different methods and materials. The bleeding of bone marrow can be mostly stopped by bone wax. However, the wax cannot be absorbed, which leads to artificial prosthesis loosening, foreign matter reaction, and infection. Here, a bioactive glass/chitosan/carboxymethyl cellulose (BG/CS/CMC) composite scaffold was designed to replace traditional wax. WST-1 assay indicated the BG/CS/CMC composite resulted in excellent biocompatibility with no cytotoxicity. In vivo osteogenesis assessment revealed that the BG/CS/CMC composite played a dominant role in bone regeneration and hemostasis. The BG/CS/CMC composite had the same hemostasis effect as bone wax; in addition its biodegradation also led to the functional reconstruction of bone defects. Thus, BG/CS/CMC scaffolds can serve as a potential material for bone repair and hemostasis in critical-sized bone defects.
authors.affiliation: Department of Orthopaedics, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Pan
authors.forename: Zuoqin
authors.initials: Z
authors.lastname: Yan
authors.forename: Zhenjun
authors.initials: Z
authors.lastname: Yao
authors.forename: Wenshuai
authors.initials: W
authors.lastname: Fan
authors.forename: Changan
authors.initials: C
authors.lastname: Guo
mesh_terms: D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D005269:Femur / Q000187:drug effects / Q000293:injuries / Q000473:pathology / Q000601:surgery; D005898:Glass / Q000737:chemistry*; D006490:Hemostatics / Q000737:chemistry* / Q000494:pharmacology; D059630:Mesenchymal Stem Cells; D011817:Rabbits; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018786:Bone Substitutes; D006490:Hemostatics; D048271:Chitosan; D002266:Carboxymethylcellulose Sodium