title: Autism spectrum disorder: an omics perspective.
abstract: Current directions in autism spectrum disorder (ASD) research may require moving beyond genetic analysis alone, based on the complexity of the disorder, heterogeneity and convergence of genetic alterations at the cellular/functional level. Mass spectrometry (MS) has been increasingly used to study CNS disorders, including ASDs. Proteomic research using MS is directed at understanding endogenous protein changes that occur in ASD. This review focuses on how MS has been used to study ASDs, with particular focus on proteomic analysis. Other neurodevelopmental disorders have been investigated using MS, including fragile X syndrome (FXS) and Smith-Lemli-Opitz Syndrome (SLOS), genetic syndromes highly associated with ASD comorbidity.
authors.affiliation: Biochemistry & Proteomics Group, Department of Chemistry & Biomolecular Science, Clarkson University, Potsdam, NY, USA; SUNY Plattsburgh Neuropsychology Clinic and Psychoeducation Services, Plattsburgh, NY, USA.
authors.forename: Alisa G
authors.initials: AG
authors.lastname: Woods
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Wormwood
authors.forename: Armand G Ngounou
authors.initials: AG
authors.lastname: Wetie
authors.forename: Roshanak
authors.initials: R
authors.lastname: Aslebagh
authors.forename: Bernard S
authors.initials: BS
authors.lastname: Crimmins
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Holsen
authors.forename: Costel C
authors.initials: CC
authors.lastname: Darie
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis* / Q000378:metabolism*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D020543:Proteome
keywords: Autism spectrum disorder; Neurodevlopmental disorders