title: Hepatitis associated aplastic anemia: case report and discussion.
abstract: Aplastic anemia (AA) is thought to represent an autoimmune disorder leading to generation of activated CD8+ T-cells that target the bone marrow precursors. Hepatitis associated aplastic anemia (HAAA) is a subtype of aplastic anemia that develops within several months ofan episode of acute hepatitis. Etiologic agents include hepatitis viruses (A-E and G), Epstein-Bar virus, cytomegalovirus, HIV, parvovirus B19, and echoviruses amongst others. However, most HAAA cases are labeled "idiopathic" as the inciting agent cannot be identified. Drugs and/or toxins are rarely causal factors. We describe herein a unique case of HAAA linked with the anabolic steroid methasterone that caused a transient cholestatic hepatitis and, subsequently, a severe aplastic anemia in a young man.
authors.forename: Arushi
authors.initials: A
authors.lastname: Khurana
authors.forename: Constantin A
authors.initials: CA
authors.lastname: Dasanu
mesh_terms: D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D000741:Anemia, Aplastic / Q000209:etiology*; D019587:Dietary Supplements / Q000009:adverse effects*; D006505:Hepatitis / Q000150:complications* / Q000209:etiology*; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D045930:Anabolic Agents