title: Evaluation of antibacterial, antifungal and modulatory activity of methanol and ethanol extracts of Padina sanctae-crucis.
abstract: BACKGROUND
  Multi-resistantmicroorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida tropicalis e Candida krusei are the main causes of microbial infections. Padina sanctae-crucis is a seaweed often used to check the contamination of ecosystems by materials such as heavy metals, but studies of the antimicrobial activity of the same seaweed were not found.
  
  
  METHODS
  The tests for the minimum inhibitory concentration and modulation of microbial resistance, with the use of ethanolic and methanolic extracts of Padina Sanctae-cruces combined with drugs of the class of aminoglycosides and antifungal were used to evaluate the activity against the cited microorganisms.
  
  
  RESULTS
  Was observed a modulation of antibiotic activity between the natural products and the E. coli and S. aureus strains, indicating a synergism and antagonism respectively.
  
  
  CONCLUSIONS
  The results showed a moderate modulatory effect against some microorganisms studied.
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Lavouisier F B
authors.initials: LF
authors.lastname: Nogueira
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Edson C
authors.initials: EC
authors.lastname: Morais
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Maria A D
authors.initials: MA
authors.lastname: Brito
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Beatriz S
authors.initials: BS
authors.lastname: Santos
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Doanny L
authors.initials: DL
authors.lastname: Vale
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Bruno F F
authors.initials: BF
authors.lastname: Lucena
authors.affiliation: Faculdade de Ciências Aplicadas Doutor Leão Sampaio (College), Juazeiro do Norte - CE, Brasil.
authors.forename: Fernando G
authors.initials: FG
authors.lastname: Figueredo
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Glaucia M M
authors.initials: GM
authors.lastname: Guedes
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Saulo R
authors.initials: SR
authors.lastname: Tintino
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Celestina E S
authors.initials: CE
authors.lastname: Souza
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, João Pessoa - PB, Brasil.
authors.forename: Raquel B S S
authors.initials: RB
authors.lastname: Nogueira
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Edinardo F F
authors.initials: EF
authors.lastname: Matias
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Maria Fb
authors.initials: MF
authors.lastname: Morais-Braga
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, João Pessoa - PB, Brasil.
authors.forename: Emídio V L
authors.initials: EV
authors.lastname: Cunha
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba - UFPB, João Pessoa - PB, Brasil.
authors.forename: Micheline A
authors.initials: MA
authors.lastname: Lima
authors.affiliation: Departamento de Química Biológica, Universidade Regional do Cariri - URCA, Crato - CE, Brasil.
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D000431:Ethanol / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D000432:Methanol / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000459:Phaeophyceae / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012624:Seaweed
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D000431:Ethanol; D000432:Methanol
keywords: Padina Sanctae-crucis; antimicrobial activity; modulation; multi-resistant microorganisms