title: Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury.
abstract: Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.
authors.affiliation: School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Gan
authors.affiliation: School of Traumatology and Orthopedics, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, Fujian Province, China.
authors.forename: Guoyao
authors.initials: G
authors.lastname: An
keywords: Bax; Bcl-2; Chinese medicine; Danshen; Tanshinone IIa; cell apoptosis; heat shock protein 70; neural regeneration; spinal ischemia/reperfusion injury