title: Homocysteine as a risk factor for hypertension: a 2-year follow-up study.
abstract: Homocysteine (Hcy) is regarded as a risk factor for hypertension, but research on the causal relationship between Hcy and hypertension is limited. In the present study, we prospectively tracked the blood pressure progression of a normotensive population with different Hcy levels over a 2-year period. The incidence of hypertension with increasing Hcy quartiles produced an approximately U-shaped curve, with significance in males. Compared with the third quartile, the risk of hypertension in the first and second quartiles was increased by 1.55 (95% confidence interval [CI] 1.154-2.081) fold and 1.501 (95% CI 1.119-2.013) fold, respectively, with the increase being more significant in males. In conclusion, Hcy is related to hypertension incidence with the results approximating an U-shaped curve. Low Hcy levels might also increase the risk of hypertension.
authors.affiliation: Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing, China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Health Department of Kailuan Group, Tangshan, China.
authors.forename: Shuohua
authors.initials: S
authors.lastname: Chen
authors.affiliation: Linxi Hospital, Affiliated Kailuan General Hospital, Hebei United University, Tangshan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yao
authors.affiliation: Department of Cardiology, The Kailuan General Hospital, Hebei United University, Tangshan, China.
authors.forename: DongQing
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Kailuan General Hospital, Hebei United University, Tangshan, China.
authors.forename: YanXiu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Rheumatology and Immunology, The Kailuan General Hospital, Hebei United University, Tangshan, China.
authors.forename: YuQing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, The Kailuan General Hospital, Hebei United University, Tangshan, China.
authors.forename: ShouLing
authors.initials: S
authors.lastname: Wu
authors.affiliation: Department of Cardiology, Beijing Chao-Yang Hospital, Capital Medical University, Chaoyang District, Beijing, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Cai
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D006710:Homocysteine