title: Contrasting infection susceptibility of the Japanese macaques and cynomolgus macaques to closely related malaria parasites, Plasmodium vivax and Plasmodium cynomolgi.
abstract: Although the human malaria parasite Plasmodium vivax is closely related to Asian Old World monkey malaria parasites, there are no reports of P. vivax infections in macaques. In this study, we compared the infectivity of P. vivax and Plasmodium cynomolgi in Japanese macaques (Macaca fuscata) and in cynomolgus macaques (Macaca fascicularis). The Japanese macaques were highly susceptible to P. cynomolgi but not to P. vivax, whereas cynomolgus macaques showed mild/limited P. cynomolgi infection and were, also, not susceptible to P. vivax. Serotyping and amino acid sequence comparison of erythrocyte surface Duffy antigen/receptor for chemokines (DARC) indicate that the Japanese macaque DARC sequence is nearly identical to that of rhesus (Macaca mulatta) and cynomolgus macaques. This suggests that the macaques share a common mechanism for preventing P. vivax infection. Comparison of amino acid sequences of the Duffy-binding-like (DBL) domain from several different Plasmodium species suggests that P. vivax DBLs will not bind to macaque DARCs, which can explain the lack of P. vivax infectivity. The DBL sequence analyses also suggest that P. cynomolgi DBLs may target Japanese macaque erythrocytes through a DARC-independent interaction.
authors.affiliation: Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan; Department of Biology and Geosciences, Graduate School of Science, Osaka City University, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Tachibana
authors.affiliation: Laboratory of Tropical Medicine and Parasitology, Institute of International Education and Research, Dokkyo Medical University, Shimotsuga, Tochigi 321-0293, Japan. Electronic address: skawai@dokkyomed.ac.jp.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kawai
authors.affiliation: The Corporation for Production and Research of Laboratory Primates, Tsukuba, Ibaraki 305-0843, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Katakai
authors.affiliation: Japanese Red Cross Kinki Block Blood Center, Ibaraki, Osaka 567-0085, Japan; Japanese Red Cross Osaka Blood Center, Joto-ku, Osaka 536-8505, Japan.
authors.forename: Hideo
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Japanese Red Cross Osaka Blood Center, Joto-ku, Osaka 536-8505, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Nakade
authors.affiliation: Tsukuba Primate Research Center, National Institute of Biomedical Innovation, Tsukuba, Ibaraki 305-0843, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yasutomi
authors.affiliation: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Horii
authors.affiliation: Laboratory of Malariology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan; Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tanabe
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000737:chemistry / Q000235:genetics*; D004198:Disease Susceptibility; D006801:Humans; D008251:Macaca / Q000097:blood / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D008252:Macaca fascicularis / Q000097:blood / Q000235:genetics / Q000276:immunology; D008253:Macaca mulatta / Q000097:blood / Q000235:genetics / Q000276:immunology; D008288:Malaria / Q000469:parasitology / Q000662:veterinary*; D016780:Malaria, Vivax / Q000469:parasitology / Q000662:veterinary*; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000469:parasitology*; D016789:Plasmodium cynomolgi / Q000235:genetics / Q000472:pathogenicity*; D010966:Plasmodium vivax / Q000235:genetics / Q000472:pathogenicity*; D015800:Protozoan Proteins / Q000737:chemistry / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000235:genetics*; D012703:Serotyping; D013045:Species Specificity
chemical_list: D000953:Antigens, Protozoan; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface
keywords: Macaques; Malaria; Plasmodium cynomolgi; Plasmodium vivax; Susceptibility