title: Adult sublingual schwannoma with angioma-like features and foam cell vascular change.
abstract: Schwannomas are benign, slow-growing neoplasms of the neural sheaths. They occur rarely in a sublingual location; 9 cases have been reported to our knowledge. We aimed to report the case of a sublingual schwannoma with peculiar morphological features. A 23-year-old woman presented for a right sublingual mass, clinically diagnosed as a vascular malformation. A pleomorphic adenoma was suggested by cytology examination. The diagnosis of schwannoma was made on the resected specimen. The tumour, measuring 4.1 cm, showed several angioma-like vessel agglomerates and macrophage thickening of the intratumour vessel wall. Tumour cells expressed diffusely S100 protein, as well as CD56 and podoplanin. In conclusion, we report the case of a sublingual schwannoma, of peculiar morphology, with presence of pseudo-angioma aggregates and foam cell thickening of the vessel wall, features which were of clinical relevance.
authors.affiliation: Adriana Handra-Luca, MD, PhD, Service d'Anatomie Pathologique, APHP Avicenne, Universite Paris Nord Sorbonne Cite, 125, rue de Stalingrad, 93000 Bobigny, France, phone: +33 1 48955555, ext. 2047/5601, fax: +33 1 48955602, e-mail: adriana.handra-luca@avc.aphp.fr.
authors.forename: Sarah
authors.initials: S
authors.lastname: Taconet
authors.forename: Philippe
authors.initials: P
authors.lastname: Gorphe
authors.forename: Adriana
authors.initials: A
authors.lastname: Handra-Luca
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005487:Foam Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D009062:Mouth Neoplasms / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor