title: Evaluating dissociated optic nerve fiber layer appearance using en face layer imaging produced by optical coherence tomography.
abstract: OBJECTIVE
  To investigate the incidence of and risk factors for a dissociated optic nerve fiber layer (DONFL) appearance after pars plana vitrectomy (PPV).
  
  
  METHODS
  We retrospectively reviewed 189 eyes that underwent PPV with internal limiting membrane removal and judged the presence/absence of an apparent DONFL based on en face layer images produced by spectral-domain optical coherence tomography (SD-OCT).
  
  
  RESULTS
  An apparent DONFL was observed in 47 (24.9%) eyes. The incidence of an apparent DONFL was significantly higher in the macular hole (MH) group (76.5%) than in the non-MH group (epiretinal membrane, diabetic macular edema, retinal vein occlusion, and others; 4.9%; p < 0.001). In the logistic regression analysis, surgical indication for MH was identified as the most significant DONFL risk factor (odds ratio 63.7; p = 1.05 × 10(-8)).
  
  
  CONCLUSIONS
  Postoperative OCT en face layer imaging clarified that MH eyes are liable to have an apparent DONFL following PPV.
authors.affiliation: Division of Ophthalmology, Department of Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Sentaro
authors.initials: S
authors.lastname: Kusuhara
authors.forename: Wataru
authors.initials: W
authors.lastname: Matsumiya
authors.forename: Hisaori
authors.initials: H
authors.lastname: Imai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Honda
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Tsukahara
authors.forename: Akira
authors.initials: A
authors.lastname: Negi
mesh_terms: D000368:Aged; D019773:Epiretinal Membrane / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology*; D011184:Postoperative Period; D012167:Retinal Perforations / Q000175:diagnosis*; D012189:Retrospective Studies; D012307:Risk Factors; D041623:Tomography, Optical Coherence / Q000379:methods*; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy