title: Indolent T-lymphblastic proliferation: report of a case involving the upper aerodigestive tract.
abstract: T-lymphoblastic lymphoma (T-LBP) is a high-grade malignant lymphoma, which possesses the characteristic of high metastasis and high mortality without treatment. We are presenting a special T-lymphoblastic proliferation involving in the oropharynx, nasopharynx, sinus and trachea in a patient with local involved about 15-years without systemic dissemination. The immunophenotype of this case was similar to T-LBP. The proliferous cells were positive for terminal deoxynucleotidyl transferase (TdT), CD3, and appeared co-expression CD4 and CD8. No clonal rearrangements of TCRγ and/or TCRβ gene were detected. Indolent T-lymphoblastic proliferations rarely occurred or unusually could not be diagnosed, combing with the relevant literature and clinically indolent manifestation, we interpreted this case as indolent T-lymphoblastic proliferation (iT-LBPs). So far, the mechanism of the T-lymphoblastic proliferations is still uncertain and requires further study.
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Tengfei
authors.initials: T
authors.lastname: Liu
authors.affiliation: Department of Pathology, The Central Hospital of Longgang Shenzhen, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Pathology, School of Basic Medical Sciences, Southern Medical University Guangzhou, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Pathology, Nanfang Hospital, Southern Medical University Guangzhou, China.
authors.forename: Zuguo
authors.initials: Z
authors.lastname: Li
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001706:Biopsy; D049109:Cell Proliferation; D005260:Female; D019672:Genes, T-Cell Receptor; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D012142:Respiratory Tract Neoplasms / Q000235:genetics / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor
keywords: T-lymphoblastic lymphoma; indolent T-lymphoblastic proliferation; upper aerodigestive tract