title: Rhodium(III)-catalysed aerobic synthesis of highly functionalized indoles from N-arylurea under mild conditions through C-H activation.
abstract: A Rh(III) catalysed amino arylation of alkynes using copper as the terminal oxidant for regeneration of the catalytically active species under aerobic conditions is described. This novel C-H activation reaction was applied to the synthesis of a wide range of substituted indoles from N-arylureas.
authors.affiliation: Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Linnæus University, SE-391 82 Kalmar, Sweden. ian.nicholls@lnu.se.
authors.forename: Subban
authors.initials: S
authors.lastname: Kathiravan
authors.forename: Ian A
authors.initials: IA
authors.lastname: Nicholls
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis*; D016877:Oxidants / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007211:Indoles; D016877:Oxidants; D003300:Copper; D014508:Urea; D012238:Rhodium