title: [Laboratory surveillance for invasive meningococcal disease in Chile, 2006-2012].
abstract: BACKGROUND
  Laboratory surveillance of Invasive Meningococcal Disease (IMD) is performed by the Institute of Public Health of Chile. It confirms identification, classifies in serogroups and analyzes the genetic profiles of Neisseria meningitidis isolates from laboratories throughout the country.
  
  
  OBJECTIVE
  To show the results of this surveillance from 2006 to 2012.
  
  
  METHODS
  A descriptive data analysis of the confirmed cases of IMD and serological characterization, susceptibility and genetic profiles of the isolates. The analysis was disaggregated by serogroup, age and region.
  
  
  RESULTS
  From 2006 to 2012, 486 isolates of N. meningitidis were confirmed. In 2011 a rise in IMD rates was observed due to an increase in W serogroup cases, mainly affecting children aged 5 years or less. Serogroup W became the most prevalent during 2012 (58.3%), replacing the historically prevalent serogroup B. Predominating strains belonged to ST-32 complex/ET-5 complex (40, 4% of strains) and ST-41/44 complex/ Lineage 3 (45, 9% of strains).
  
  
  CONCLUSIONS
  Laboratory surveillance has allowed the early detection of increasing IMD caused by serogroup W, which is emergent in Chile. This information has reinforced the daily monitoring of new cases, in collaboration with all the clinical laboratories of the country.
authors.forename: Pamela
authors.initials: P
authors.lastname: Araya
authors.forename: Janepsy
authors.initials: J
authors.lastname: Díaz
authors.forename: Mabel
authors.initials: M
authors.lastname: Seoane
authors.forename: Jorge
authors.initials: J
authors.lastname: Fernández
authors.forename: Solana
authors.initials: S
authors.lastname: Terrazas
authors.forename: Andrea
authors.initials: A
authors.lastname: Canals
authors.forename: Alejandra
authors.initials: A
authors.lastname: Vaquero
authors.forename: Gisselle
authors.initials: G
authors.lastname: Barra
authors.forename: Juan C
authors.initials: JC
authors.lastname: Hormazábal
authors.forename: Paola
authors.initials: P
authors.lastname: Pidal
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Valenzuela
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques; D002648:Child; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D062665:Epidemiological Monitoring; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009345:Neisseria meningitidis / Q000187:drug effects / Q000235:genetics; D011159:Population Surveillance; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents