title: Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection.
abstract: OBJECTIVE
  To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer (CRC) and benign patients and postoperatively after CRC resection.
  
  
  METHODS
  A plasma bank was screened for minimally invasive colorectal cancer resection (MICR) for CRC and benign disease (BEN) patients for whom preoperative, early postoperative, and 1 or more late postoperative samples (postoperative day 7-27) were available. Monocyte chemotactic protein-1 (MCP-1) levels (pg/mL) were determined via enzyme linked immuno-absorbent assay.
  
  
  RESULTS
  One hundred and two CRC and 86 BEN patients were studied. The CRC patient's median preoperative MCP-1 level (283.1, CI: 256.0, 294.3) was higher than the BEN group level (227.5, CI: 200.2, 245.2; P = 0.0004). Vs CRC preoperative levels, elevated MCP-1 plasma levels were found on postoperative day 1 (446.3, CI: 418.0, 520.1), postoperative day 3 (342.7, CI: 320.4, 377.4), postoperative day 7-13 (326.5, CI: 299.4, 354.1), postoperative day 14-20 (361.6, CI: 287.8, 407.9), and postoperative day 21-27 (318.1, CI: 287.2, 371.6; P < 0.001 for all).
  
  
  CONCLUSIONS
  Preoperative MCP-1 levels were higher in CRC patients (vs BEN). After MICR for CRC, MCP-1 levels were elevated for 1 mo and may promote angiogenesis, cancer recurrence and metastasis.
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: H M C
authors.initials: HM
authors.lastname: Shantha Kumara
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Myers
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Sonali Ac
authors.initials: SA
authors.lastname: Herath
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Joon Ho
authors.initials: JH
authors.lastname: Jang
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Linda
authors.initials: L
authors.lastname: Njoh
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Yan
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Daniel
authors.initials: D
authors.lastname: Kirchoff
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Vesna
authors.initials: V
authors.lastname: Cekic
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Martin
authors.initials: M
authors.lastname: Luchtefeld
authors.affiliation: HMC Shantha Kumara, Elizabeth A Myers, Sonali AC Herath, Joon Ho Jang, Linda Njoh, Xiaohong Yan, Daniel Kirchoff, Vesna Cekic, Division of Colon and Rectal Surgery, Department of Surgery, Mount Sinai-Roosevelt Hospital Center, New York, NY 10019, United States.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Whelan
keywords: Colorectal cancer; Minimally invasive colorectal resection angiogenesis; Monocyte chemotactic protein-1