title: Mutagenic and antimutagenic effects of Heterotheca inuloides.
abstract: The antioxidant and hepatoprotective effects of Heterotheca inuloides have been reported before, nevertheless its use as a possible chemopreventive agent has not been documented. The aim of this study was to evaluate the mutagenic and antimutagenic activities of H. inuloides extracts using the Ames test. Both, the methanolic and acetonic extracts, were mutagenic in the TA98 but not in TA100 or TA102 strains. On the other hand, the methanolic extract reduced the mutagenicity of norfloxacin, benzo[a]pyrene and 2-aminoanthracene. Quercetin, one of the main components in the methanolic extract, also presented a mutagenic/antimutagenic dual effect and is an inhibitor of Cytochrome P450 (CYP) 1A. The antigenotoxic properties of H. inuloides could be due to the antioxidant properties previously reported and to its CYP inhibitory effect mediated by quercetin. Further studies with in vivo systems will afford information about H. inuloides beneficial and detrimental properties.
authors.affiliation: Hospital Juárez de México- División de Investigación.
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Ruiz-Pérez
authors.affiliation: Hospital Juárez de México- División de Investigación.
authors.forename: Myriam
authors.initials: M
authors.lastname: Arriaga-Alba
authors.affiliation: Hospital Juárez de México- División de Investigación.
authors.forename: Jaime
authors.initials: J
authors.lastname: Sánchez-Navarrete
authors.affiliation: Instituto de Investigaciones Biomédicas, UNAM. Ciudad Universitaria, apartado postal 70228, México, D.F., 04510 México.
authors.forename: Rafael
authors.initials: R
authors.lastname: Camacho-Carranza
authors.affiliation: Instituto de Investigaciones Biomédicas, UNAM. Ciudad Universitaria, apartado postal 70228, México, D.F., 04510 México.
authors.forename: Sandra
authors.initials: S
authors.lastname: Hernández-Ojeda
authors.affiliation: Instituto de Investigaciones Biomédicas, UNAM. Ciudad Universitaria, apartado postal 70228, México, D.F., 04510 México.
authors.forename: Javier J
authors.initials: JJ
authors.lastname: Espinosa-Aguirre
mesh_terms: D016587:Antimutagenic Agents / Q000008:administration & dosage* / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D019659:Asteraceae / Q000737:chemistry*; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics; D016296:Mutagenesis / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000235:genetics; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D016587:Antimutagenic Agents; D000975:Antioxidants; D010936:Plant Extracts; D011794:Quercetin; D019363:Cytochrome P-450 CYP1A1