title: Prostate changes related to therapy: with special reference to hormone therapy.
abstract: Hormone and radiation therapy have traditionally been used in prostate cancer (PCa). Morphological effects are often identified in needle biopsies and surgical specimens. A range of histological changes are seen in the non-neoplastic prostate and in the pre-neoplastic and neoplastic areas. Other ablative therapies, including cryotherapy, and emerging focal therapies, such as high-intensity focused ultrasound, photodynamic therapy and interstitial laser thermotherapy, may induce changes on the prostate. As new compounds are developed for prostate cancer treatment, it is important to document their effects on benign and neoplastic prostate tissue.
authors.affiliation: Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, I-60126 Torrette, Ancona, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Mazzucchelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Lopez-Beltran
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Galosi
authors.forename: Antonio
authors.initials: A
authors.lastname: Zizzi
authors.forename: Marina
authors.initials: M
authors.lastname: Scarpelli
authors.forename: Sergio
authors.initials: S
authors.lastname: Bracarda
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Montironi
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017679:Cryotherapy; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D010778:Photochemotherapy; D011467:Prostate / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy*; D011878:Radiotherapy
chemical_list: D018931:Antineoplastic Agents, Hormonal
keywords: cryotherapy; emerging ablative therapies; hormone therapy; nutritional supplements; prostate cancer; radiation therapy; target molecular therapies