title: Neonatal outcome in pregnant patients with antiphospholipid syndrome.
abstract: OBJECTIVE
  The study aim was to evaluate pregnancy outcomes in patients with antiphospholipid syndrome (APS) and to determine which clinical parameters present risk factors for adverse pregnancy outcomes in these patients.
  
  
  METHODS
  The study included 55 patients with APS treated at the Clinic for Ob/Gyn, Clinical Center of Serbia, from 2006 to 2012. The control group consisted of 55 healthy pregnant women. Data regarding previous pregnancies and conception method were registered. Immunological and laboratory tests were performed. Pregnancy outcomes, including miscarriage, intrauterine fetal death, hypertensive disorders, diabetes mellitus, phlebothrombosis, fetal growth restriction, premature delivery, delivery method, perinatal asphyxia, respiratory distress syndrome, intraventricular hemorrhage, and necrotizing enterocolitis were followed.
  
  
  RESULTS
  The premature delivery rate in APS patients was 31.8%, and pregnancy loss was 18.2%. Significantly more patients with APS had thrombocytopenia, pregnancy losses, intrauterine growth restriction, and perinatal asphyxia compared with the control group. More miscarriages, preterm delivery, lower birth weight, preeclampsia, and IgM anticardiolipin antibody levels significantly correlated with adverse pregnancy outcomes. Although rare, respiratory distress syndrome can also worsen neonatal health status. According to ROC analysis, previous miscarriages correctly explained 66.3% of adverse pregnancy outcome cases. We generated four equations of adverse pregnancy outcome risk factors.
  
  
  CONCLUSIONS
  The most important prognostic factor for pregnancy outcome in APS patients is the number of previous miscarriages. Using appropriate current therapeutic protocol can enable live birth of a healthy newborn in most cases.
authors.forename: Katarina
authors.initials: K
authors.lastname: Jeremic
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Stefanovic
authors.forename: Jelena
authors.initials: J
authors.lastname: Dotlic
authors.forename: Jelena
authors.initials: J
authors.lastname: Stojnic
authors.forename: Sasa
authors.initials: S
authors.lastname: Kadija
authors.forename: Zoran
authors.initials: Z
authors.lastname: Vilendecic
authors.forename: Tijana
authors.initials: T
authors.lastname: Janjic
authors.forename: Jelena
authors.initials: J
authors.lastname: Jeremic
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D016736:Antiphospholipid Syndrome; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology*; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors