title: The imaging core lab perspective on glioblastoma imaging and response assessment in clinical trials.
abstract: Multicenter clinical trials that include medical images as a key component of response assessment often involve an imaging service provider (a core laboratory or contract research organization) to collect images and often to provide independent assessments of treatment response. The brief discussion and recommendations provided here are not intended as a rigorous academic analysis but reflect the practical experience accumulated at one such institution, which has conducted the image collection and review for numerous glioblastoma trials, in every phase of drug development, encompassing over 4000 patients scanned at over 900 sites.
authors.affiliation: ICON Medical Imaging, Warrington, Pennsylvania.
authors.forename: Gregory V
authors.initials: GV
authors.lastname: Goldmacher
authors.affiliation: ICON Medical Imaging, Warrington, Pennsylvania.
authors.forename: David
authors.initials: D
authors.lastname: Raunig
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D003952:Diagnostic Imaging; D003954:Diagnostic Services; D005909:Glioblastoma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D015337:Multicenter Studies as Topic; D066066:Response Evaluation Criteria in Solid Tumors
keywords: RANO; clinical trial; glioblastoma; imaging; independent review