title: Hyperbaric oxygen treatment outcome for different indications from a single center.
abstract: BACKGROUND
  Hyperbaric oxygen (HBO) is used as an adjunctive therapy for a variety of indications. However, there is a lack of high-quality research evaluating HBO treatment outcomes for different indications available in the current literature.
  
  
  METHODS
  We retrospectively reviewed all patients who underwent HBO therapy at a single hyperbaric center from January 2010 to December 2013 using predetermined criteria to analyze successful, improved, or failed treatment outcomes for the following indications: chronic refractory osteomyelitis, diabetic foot ulcer, failed flap or skin graft, osteoradionecrosis, soft tissue radiation necrosis, and multiple coexisting indications.
  
  
  RESULTS
  Among the included 181 patients treated with adjunctive HBO at our center, 81.8% had either successful or improved treatment outcomes. A successful or improved outcome was observed in 82.6% of patients treated for chronic refractory osteomyelitis (n = 23), 74.1% for diabetic foot ulcer (n = 27), 75.7% for failed flap or skin graft (n = 33), 95.7% for osteoradionecrosis (n = 23), 88.1% for soft tissue radiation necrosis (n = 42), and 72.4% for multiple coexisting indications (n = 29). Among 4 patients treated for other indications, 100% of the cases were either successful or improved.
  
  
  CONCLUSIONS
  This study has provided a comprehensive outcome survey of using HBO for the previously mentioned indications at our center. It supplements the literature with more evidence to support the consideration of HBO in different indications.
authors.affiliation: Vascular Medicine, Minneapolis Heart Institute Vascular Medicine, Minneapolis, MN; Hyperbaric and Oxygen Center, Minneapolis Heart Institute Vascular Medicine, Minneapolis, MN; Thrombophilia and Anticoagulation Clinic, Minneapolis Heart Institute Vascular Medicine, Minneapolis, MN. Electronic address: Nedaa.Skeik@allina.com.
authors.forename: Nedaa
authors.initials: N
authors.lastname: Skeik
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN.
authors.forename: Brandon R
authors.initials: BR
authors.lastname: Porten
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN.
authors.forename: Erin
authors.initials: E
authors.lastname: Isaacson
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN.
authors.forename: Jenny
authors.initials: J
authors.lastname: Seong
authors.affiliation: Hyperbaric Oxygen Clinic, Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Deana L
authors.initials: DL
authors.lastname: Klosterman
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN.
authors.forename: Ross F
authors.initials: RF
authors.lastname: Garberich
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN; Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Jason Q
authors.initials: JQ
authors.lastname: Alexander
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Adnan
authors.initials: A
authors.lastname: Rizvi
authors.affiliation: Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Jesse M
authors.initials: JM
authors.lastname: Manunga
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN; Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN; University of Minnesota, Minneapolis, MN.
authors.forename: Andrew
authors.initials: A
authors.lastname: Cragg
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN; Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN; Mission Surgery Program-Guatemala Surgery, Minneapolis, MN.
authors.forename: John
authors.initials: J
authors.lastname: Graber
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN; Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN; Wound Clinic at Abbott Northwestern Hospital, Minneapolis, MN.
authors.forename: Peter
authors.initials: P
authors.lastname: Alden
authors.affiliation: Minneapolis Heart Institute Foundation, Minneapolis, MN; University of Minnesota, Minneapolis, MN; Vascular and Endovascular Surgery, Minneapolis Heart Institute at Abbott Northwestern Hospital, Minneapolis, MN; Abbott Northwestern Hospital Vascular Center, Minneapolis, MN.
authors.forename: Timothy
authors.initials: T
authors.lastname: Sullivan
mesh_terms: D000368:Aged; D002908:Chronic Disease; D017719:Diabetic Foot / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D010019:Osteomyelitis / Q000175:diagnosis / Q000628:therapy*; D010025:Osteoradionecrosis / Q000175:diagnosis / Q000628:therapy*; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy*; D012189:Retrospective Studies; D016038:Skin Transplantation / Q000009:adverse effects; D013524:Surgical Flaps / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing