title: Profile of Acute Asthma Exacerbation in Drug Users.
abstract: The characteristics of patients who use heroin, cocaine, or both and present with acute asthma exacerbations have not been well studied. In this retrospective study, we aimed to study the demographic characteristics of this patient population, the characteristics of their asthma attack, and the risk factors for the need for invasive mechanical ventilation in this patient population. We reviewed the charts of patients discharged from an inner-city hospital with a diagnosis of acute asthma exacerbation. Individuals who used either heroin or cocaine or both within 24 hours of presenting to the emergency department were identified as a cohort of drug users. The rest were classified as non-drug users. Both groups were compared, and a univariate analysis was performed. To assess the predictive value of drug use for the need for intubation in the presence of confounding factors, logistic regression analysis was performed to identify whether using cocaine or heroin or both was an individual predictor for the need for invasive ventilation. Data from 218 patients were analyzed. Drug users (n = 85) were younger (mean age in years 43.9 vs. 50.5, P < 0.01), predominantly male (63.5% vs. 33.8%, P < 0.01), and more likely to be cigarette smokers (90.6% vs. 57.6%, P < 0.01). A medical history of intubation and admissions to the intensive care unit (ICU) was more common among drug users (56.5% vs. 29.3%, P < 0.01 and 54.1% vs. 38.3%, P < 0.03, respectively). Drug use was associated with increased need for invasive mechanical ventilation (35% vs. 23.3%, P = 0.05). Non-drug users were more likely to be using inhaled corticosteroids (48.9% vs. 32.9%, P = 0.03) and had longitudinal care established with a primary care provider (50.6% vs. 68.9%, P < 0.01). After adjusting for a history of mechanical ventilation, history of ICU admission, use of systemic corticosteroids, smoking, and acute physiological assessment and chronic health evaluation 2 score, drug use remained predictive for the need for mechanical ventilation (P = 0.026). Acute asthma exacerbations triggered by cocaine and heroin should be treated aggressively because they represent a cohort with poor follow-up and undertreated asthma as outpatients and are associated with increased need for invasive mechanical ventilation and ICU admission during acute exacerbation.
authors.affiliation: 1Division of Pulmonary & Critical Care Medicine, Southern Illinois University School of Medicine, Springfield, IL; 2University of Arizona, Tucson, AZ; 3University of Arizona, Tucson, AZ; 4Mayo Clinic, Rochester, MN; and 5The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL.
authors.forename: Viral
authors.initials: V
authors.lastname: Doshi
authors.forename: Sundeep
authors.initials: S
authors.lastname: Shenoy
authors.forename: Aarthi
authors.initials: A
authors.lastname: Ganesh
authors.forename: Muhammad Adeel
authors.initials: MA
authors.lastname: Rishi
authors.forename: Janos
authors.initials: J
authors.lastname: Molnar
authors.forename: Joseph
authors.initials: J
authors.lastname: Henkle
mesh_terms: D000328:Adult; D017677:Age Distribution; D001249:Asthma / Q000453:epidemiology*; D019970:Cocaine-Related Disorders / Q000453:epidemiology*; D015897:Comorbidity; D018450:Disease Progression; D055030:Drug Users / Q000706:statistics & numerical data*; D004636:Emergency Service, Hospital; D005260:Female; D006556:Heroin Dependence / Q000453:epidemiology*; D006760:Hospitalization; D006801:Humans; D007362:Intensive Care Units / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D017678:Sex Distribution; D012907:Smoking / Q000453:epidemiology*