title: Theoretical study on the structural and antioxidant properties of some recently synthesised 2,4,5-trimethoxy chalcones.
abstract: The free radical scavenging activity of a series of 2,4,5-trimethoxy chalcones has been computationally explored using the density functional theory (DFT) method. Three potential working mechanisms, hydrogen atom transfer (HAT), stepwise electron transfer proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET) have been investigated. The physiochemical parameters including O-H bond dissociation enthalpy (BDE), ionisation potential (IP), proton dissociation enthalpy (PDE), proton affinity (PA) and electron transfer enthalpy (ETE) have been calculated in gas phase and solvents. The order of antioxidant efficiencies predicted theoretically in this work is in good agreement with that reported by experimental results. The results obtained demonstrate that HAT would be the most favourable mechanism in the gas and benzene phases, whereas the SPLET mechanism is the thermodynamically preferred pathway in polar media. In addition, the importance of the A-ring on the radical scavenging capabilities of chalcones was also confirmed.
authors.affiliation: School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.
authors.forename: Guirong
authors.initials: G
authors.lastname: Wang
authors.affiliation: Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: xueyunsheng@xzmc.edu.cn.
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Xue
authors.affiliation: Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.
authors.forename: Lin
authors.initials: L
authors.lastname: An
authors.affiliation: Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.
authors.forename: Youguang
authors.initials: Y
authors.lastname: Zheng
authors.affiliation: School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.
authors.forename: Yunyan
authors.initials: Y
authors.lastname: Dou
authors.affiliation: Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Chemical and Biological Pharmaceutical Engineering Research Center, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China; School of Pharmacy, Xuzhou Medical College, No. 209, Tongshan Road, Xuzhou, Jiangsu 221004, China. Electronic address: njuliuyi2003@gmail.com.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry*; D004579:Electron Transport; D016166:Free Radical Scavengers / Q000737:chemistry; D010084:Oxidation-Reduction; D059808:Polyphenols / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D000975:Antioxidants; D047188:Chalcones; D016166:Free Radical Scavengers; D059808:Polyphenols; D012997:Solvents
keywords: Chalcones; DFT; HAT; Radical scavenging activity; SET-PT; SPLET