title: Unlocking the pH-responsive degradability of fumaramic acid derivatives using photoisomerization.
abstract: Fumaramic acid derivatives can be converted into their cis isomer maleamic acid derivatives under UV illumination, and these maleamic acid derivatives show pH-responsive degradability at acidic pH only after the preceding photoisomerization. The rate of the tandem photoisomerization-degradation of fumaramic acid derivatives can be finely controlled by changing the substituents on the double bond. Photoisomerization-based unlocking of the pH-responsive degradability of fumaramic acid derivatives has strong potential for the development of multisignal-responsive smart materials in biomedical applications.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 151-747 (Republic of Korea).
authors.forename: Wonmin
authors.initials: W
authors.lastname: Choi
authors.forename: Sunyoung
authors.initials: S
authors.lastname: Kang
authors.forename: Yeongbong
authors.initials: Y
authors.lastname: Mok
authors.forename: Euddeum
authors.initials: E
authors.lastname: Park
authors.forename: Youngjun
authors.initials: Y
authors.lastname: Song
authors.forename: So Jung
authors.initials: SJ
authors.lastname: Choi
authors.forename: Yan
authors.initials: Y
authors.lastname: Lee
mesh_terms: D000143:Acids / Q000737:chemistry*; D016503:Drug Delivery Systems; D005650:Fumarates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007536:Isomerism; D009578:Nitrobenzenes / Q000737:chemistry; D055668:Photochemical Processes; D013386:Succinates / Q000737:chemistry
chemical_list: D000143:Acids; D005650:Fumarates; D009578:Nitrobenzenes; D013386:Succinates
keywords: drug delivery; pH-sensitivity; photochemistry; photoisomerization; signal-responsiveness