title: The relationship between intentional self-injurious behavior and the loudness dependence of auditory evoked potential in research volunteers.
abstract: OBJECTIVE
  Serotonergic (5-HT) functioning has been shown to be inversely associated with intentional self-injurious behaviors. The purpose of this study was to examine the association between three related self-report measures of intentional self-injurious behaviors (suicidal thoughts/behavior, history of nonsuicidal self-injury, history of severe self-harm when angry) and a putative electrophysiological index of 5-HT activity, the loudness dependence of auditory evoked potential (LDAEP).
  
  
  METHODS
  Auditory evoked potentials were recorded from 41 men (mean age = 20.69, standard deviation [SD] = 2.98) during the administration of various tone loudness stimuli, followed by completion of the self-report measures.
  
  
  RESULTS
  The component slope was associated with all measures of self-injurious behavior in the expected direction.
  
  
  CONCLUSIONS
  The LDAEP has the potential to be used as a noninvasive index of intentional self-harm disposition. Additional studies are needed using other populations, including women and treatment-seeking individuals, to determine if the LDAEP more broadly discriminates risk of self-injuring.
authors.affiliation: The University of Southern Mississippi.
authors.forename: Angelika
authors.initials: A
authors.lastname: Marsic
authors.forename: Mitchell E
authors.initials: ME
authors.lastname: Berman
authors.forename: Tammy D
authors.initials: TD
authors.lastname: Barry
authors.forename: Michael S
authors.initials: MS
authors.lastname: McCloskey
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D064368:Healthy Volunteers; D006801:Humans; D008144:Loudness Perception; D008297:Male; D044263:Receptors, Serotonin, 5-HT1 / Q000502:physiology*; D016728:Self-Injurious Behavior / Q000503:physiopathology*; D013334:Students; D059020:Suicidal Ideation; D011795:Surveys and Questionnaires; D014495:Universities; D055815:Young Adult
chemical_list: D015415:Biomarkers; D044263:Receptors, Serotonin, 5-HT1
keywords: 5-HT functioning; EEG; LDAEP; N1/P2; Self-injury