title: B-myb is a gene implicated in cell cycle and proliferation of breast cancer.
abstract: B-myb belongs to the myb family of transcription factors that include A-myb and c-myb. While A-myb and c-myb are tissue-specific, B-myb is broadly expressed in rapidly dividing cells of developing adult mammals. Results of our study showed that increased B-myb expression of was associated with the progression of breast cancer and that B-myb protein levels were significantly elevated in matched metastases. High B-myb levels also predict shorter overall survival of breast cancer patients. Moreover, B-myb stimulated transcription of target genes that promoted entry into the S and M-phases of the cell cycle, cell proliferation, migration and invasion in breast cancer. Taken together, our results strongly demonstrated that B-myb had a critical role in both cell cycle progression and tumorigenesis, and might serve as a novel potential target in the diagnosis and/or treatment of human breast cancer.
authors.affiliation: Department of Oncological Surgery, Luqiao Hospital of Taizhou Enze Medical Group Luqiao, Zhejiang, China.
authors.forename: Deyou
authors.initials: D
authors.lastname: Tao
authors.affiliation: Departments of Gynecology, Taizhou Central Hospital of Taizhou Enze Medical Group Taizhou, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Pan
authors.affiliation: Departments of Pathology, Taizhou Central Hospital of Taizhou Enze Medical Group Taizhou, China.
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Oncology, Hangzhou Cancer Hospital, The First People's Hospital of Hangzhou China.
authors.forename: Song
authors.initials: S
authors.lastname: Zheng
authors.affiliation: Department of oncological surgery, Taizhou Hospital of Taizhou Enze Medical Group Linhai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Oncological Surgery, Luqiao Hospital of Taizhou Enze Medical Group Luqiao, Zhejiang, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Fang
authors.affiliation: Department of oncological surgery, Taizhou Hospital of Taizhou Enze Medical Group Linhai, China.
authors.forename: Feilin
authors.initials: F
authors.lastname: Cao
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D057809:HEK293 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008819:Mice, Nude; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D015398:Signal Transduction; D013997:Time Factors; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D047368:Tumor Burden; D015854:Up-Regulation; D023041:Xenograft Model Antitumor Assays
chemical_list: D018797:Cell Cycle Proteins; C064352:MYBL2 protein, human; D015534:Trans-Activators
keywords: B-myb; breast cancer; cell cycle; invasion; migration; proliferation