title: μ-Opioid activation in the midbrain during migraine allodynia - brief report II.
abstract: We investigated in vivo the allodynic response of the central μ-opioid system during spontaneous migraine headaches, following a sustained pain threshold challenge on the trigeminal ophthalmic region. Six migraineurs were scanned during the ictal and interictal phases using positron emission tomography (PET) with the selective μ-opioid receptor (μOR) radiotracer [11C]carfentanil. Females were scanned during the mid-late follicular phase of two separate cycles. Patients showed ictal trigeminal allodynia during the thermal challenge that was concurrent and positively correlated with μOR activation in the midbrain, extending from red nucleus to ventrolateral periaqueductal gray matter. These findings demonstrate for the first time in vivo the high μOR activation in the migraineurs' brains in response to their allodynic experience.
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Thiago D
authors.initials: TD
authors.lastname: Nascimento
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Marcos F
authors.initials: MF
authors.lastname: DosSantos
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lucas
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Hendrik
authors.initials: H
authors.lastname: van Holsbeeck
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Misty
authors.initials: M
authors.lastname: DeBoer
authors.affiliation: 3DLab, University of Michigan Ann Arbor, Michigan.
authors.forename: Eric
authors.initials: E
authors.lastname: Maslowski
authors.affiliation: Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Love
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
authors.forename: Ilkka K
authors.initials: IK
authors.lastname: Martikainen
authors.affiliation: PET Physics Section, Division of Nuclear Medicine, Radiology Department, University of Michigan Ann Arbor, Michigan.
authors.forename: Robert A
authors.initials: RA
authors.lastname: Koeppe
authors.affiliation: Department of Obstetrics and Gynecology, University of Michigan Ann Arbor, Michigan.
authors.forename: Yolanda R
authors.initials: YR
authors.lastname: Smith
authors.affiliation: Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan.
authors.forename: Jon-Kar
authors.initials: JK
authors.lastname: Zubieta
authors.affiliation: Headache and Orofacial Pain Effort (HOPE), Biologic and Materials Sciences Department, School of Dentistry, University of Michigan Ann Arbor, Michigan ; Translational Neuroimaging Laboratory, Molecular and Behavioral Neuroscience Institute (MBNI), University of Michigan Ann Arbor, Michigan ; Michigan Center for Oral Health Research (MCOHR), School of Dentistry, University of Michigan Ann Arbor, Michigan.
authors.forename: Alexandre F
authors.initials: AF
authors.lastname: DaSilva