title: Paediatric idiopathic myelofibrosis.
abstract: Pediatric myelofibrosis is a rare disorder. It is usually secondary to other diseases. Rarely, when no underlying cause is found, it is termed idiopathic. We present here, a rare case of idiopathic myelofibrosis in a 10 year old male child. Bone marrow aspirate was dilute. Bone biopsy showed marrow fibrosis, with grade 2-3 reticulin fibres, with no evidence of granuloma, parasite or infilterative disorder. Acid fast bacillus stain was negative. Iliac lymph node biopsy showed reactive sinus histiocytosis with extramedullary hematopoeisis. Thus, diagnosis of pediatric idiopathic primary myelofibrosis was made. Idiopathic pediatric myelofibrosis should be suspected in a child with progressive pallor, hepatosplenomegaly and dry tap on bone marrow aspiration and marrow fibrosis on bone biopsy, after exclusion of secondary causes.
authors.affiliation: Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.
authors.forename: Annapurna
authors.initials: A
authors.lastname: Saksena
authors.affiliation: Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.
authors.forename: Prerna
authors.initials: P
authors.lastname: Arora
authors.affiliation: Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.
authors.forename: Nita
authors.initials: N
authors.lastname: Khurana
authors.affiliation: Department of Pediatrics, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.
authors.forename: G R
authors.initials: GR
authors.lastname: Sethi
authors.affiliation: Department of Pathology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi, 110002 Delhi India.
authors.forename: Tejinder
authors.initials: T
authors.lastname: Singh
keywords: Idiopathic; Myelofibrosis; Pediatric