title: Cytotoxic bibenzyl dimers from the stems of Dendrobium fimbriatum Hook.
abstract: The bioassay-guided chemical investigation of the stems of Dendrobium fimbriatum Hook led to the isolation of seven first reported bibenzyl dimers with a linkage of a methylene moiety, fimbriadimerbibenzyls A-G (1-7), together with a new dihydrophenanthrene derivative (S)-2,4,5,9-tetrahydroxy-9,10-dihydrophenanthrene (8) and thirteen known compounds (9-21). The structure of the new compound was established by spectroscopic analysis. Biological evaluation of bibenzyl derivatives against five human cell lines indicated that seven of those compounds exhibited broad-spectrum and cytotoxic activities with IC50 values ranging from 2.2 to 21.2 μM. Those rare bibenzyl dimers exhibited cytotoxic activities in vitro and the cytotoxicity decreased as the number of oxygen-containing groups in the structure decreases.
authors.affiliation: Anhui University of Chinese Medicine, Hefei 230031, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Feng-Qing
authors.initials: FQ
authors.lastname: Xu
authors.affiliation: The Department of Neurology of the First Affiliated Hospital of Medical University of Anhui, China.
authors.forename: Fang-Cheng
authors.initials: FC
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Fan
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Cheng-Ting
authors.initials: CT
authors.lastname: Zi
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Fa-Wu
authors.initials: FW
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Yunnan Agricultural University, Kunming 650201, China. Electronic address: 623157535@qq.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Sheng
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: zuozhili@mail.kib.ac.cn.
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Zuo
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. Electronic address: hujiangmiao@mail.kib.ac.cn.
authors.forename: Jiang-Miao
authors.initials: JM
authors.lastname: Hu
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D001632:Bibenzyls / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D031667:Dendrobium / Q000737:chemistry* / Q000378:metabolism; D019281:Dimerization; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001632:Bibenzyls
keywords: Bibenzyl dimer; Cytotoxicity; Dendrobium fimbriatum Hook; Fimbriadimerbibenzyl