title: The impact of IKZF1 deletion on the prognosis of acute lymphoblastic leukemia: an updated meta-analysis.
abstract: BACKGROUND
  Various studies have reported that IKZF1 deletion (IKZF1-d) is a poor prognostic factor for acute lymphoblastic leukemia (ALL) patients, however they do not agree on the level of significance for this deletion.
  
  
  OBJECTIVE
  To provide a quantitative assessment of this correlation, an updated meta-analysis of cohort studies was performed to derive a more precise estimation of the prognostic significance of IKZF1-d.
  
  
  METHODS
  Relevant studies were identified in PubMed, Embase, Cochrane, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang databases until January 31, 2014. A total of 15 published studies including 5021 patients were eligible for this meta-analysis. Combined hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated with random-effects model.
  
  
  RESULTS
  Combined hazard ratios suggested that IKZF1 deletion (IKZF1-d) had an unfavorable impact on event-free survival (EFS) (HR=2.32, 95%CI: 1.97-2.74) and overall survival (OS) (HR=2.56, 95%CI: 1.75-3.74) in patients with ALL. The significant role of IKZF1-d in the prognosis of ALL was also observed among different subgroups stratified by statistical methodology, ethnicity, age, detection method, risk group and duration of follow up.
  
  
  CONCLUSIONS
  The findings from this meta-analysis suggest that IKZF1 deletion can be used to serve as an independent predictive factor in patients with ALL.
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Jia
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Zhu-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Jing-Yuan
authors.initials: JY
authors.lastname: Li
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Shi-Long
authors.initials: SL
authors.lastname: Yang
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Hai-Zhao
authors.initials: HZ
authors.lastname: Zhao
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Cheng
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Ze-Bin
authors.initials: ZB
authors.lastname: Luo
authors.affiliation: Division of Hematology-Oncology, Key Laboratory of Reproductive Genetics, Children's Hospital of Zhejiang University School of Medicine, Ministry of Education, Hangzhou, Zhejiang, China.
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Tang
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002681:China; D018572:Disease-Free Survival; D006801:Humans; D051740:Ikaros Transcription Factor / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D017384:Sequence Deletion
chemical_list: D014408:Biomarkers, Tumor; C497239:IKZF1 protein, human; D051740:Ikaros Transcription Factor
keywords: Acute lymphoblastic leukemia; IKZF1; meta-analysis; prognosis