title: Understanding the PIRO concept: from theory to clinical practice - Part 1.
abstract: Despite recent advances in diagnosis and care of critically ill patients sepsis related mortality rate remains unacceptably high. Therefore, new methods of evaluation are necessary to provide an earlier and more accurate characterization of septic patients. Based on the (oncologic) TNM system, the PIRO concept was introduced as a new staging system for sepsis in order to assess risk and predict prognosis, with potential to assist in inclusion of patients in clinical studies and estimate the probability of response of patients to specific therapeutic interventions.
authors.affiliation: Centro de Tratamento Intensivo, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Lígia Sarmet Cunha Farah
authors.initials: LS
authors.lastname: Rabello
authors.affiliation: Centro de Tratamento Intensivo, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Maíra de Moraes
authors.initials: Mde M
authors.lastname: Rosolem
authors.affiliation: Núcleo de Pesquisa, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Juliana Vassalo
authors.initials: JV
authors.lastname: Leal
authors.affiliation: Centro de Tratamento Intensivo, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Márcio
authors.initials: M
authors.lastname: Soares
authors.affiliation: Centro de Tratamento Intensivo, Hospital de Clinicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
authors.forename: Thiago
authors.initials: T
authors.lastname: Lisboa
authors.affiliation: Centro de Tratamento Intensivo, Hospital de Câncer-I, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
authors.forename: Jorge Ibrain Figueira
authors.initials: JI
authors.lastname: Salluh