title: What is the incidence of biliary carcinoma in choledochal cysts, when do they develop, and how should it affect management?
abstract: The incidence of cancer in choledochal cysts (CCs) in adults was calculated to determine the timing and need for surgery. In 78 publications (1996-2010), 434 of 5780 reported CCs patients had cancer. Cholangiocarcinoma (70.4 %) and gallbladder cancer (23.5 %) were the most common malignancies. Only nine malignancies were reported before age 18 (0.42 %). In contrast, the incidence of malignancy in adults was 11.4 %. The median age for diagnosis of cancer was 42 years, and the incidence increased with each decade.
authors.affiliation: Department of Surgery, Beth Israel Medical Center, New York, NY, USA, asastry@chpnet.org.
authors.forename: Amit V
authors.initials: AV
authors.lastname: Sastry
authors.forename: Benjamin
authors.initials: B
authors.lastname: Abbadessa
authors.forename: Michael G
authors.initials: MG
authors.lastname: Wayne
authors.forename: Justin G
authors.initials: JG
authors.lastname: Steele
authors.forename: Avram M
authors.initials: AM
authors.lastname: Cooperman
mesh_terms: D000367:Age Factors; D001650:Bile Duct Neoplasms / Q000453:epidemiology* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000453:epidemiology* / Q000473:pathology; D015529:Choledochal Cyst / Q000453:epidemiology* / Q000473:pathology* / Q000601:surgery; D005706:Gallbladder Neoplasms / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015994:Incidence