title: Effects of dietary fiber with Bacillus coagulans lilac-01 on bowel movement and fecal properties of healthy volunteers with a tendency for constipation.
abstract: To elucidate the effects of Lilac LAB (Bacillus coagulans lilac-01 and okara [soy pulp] powder) on bowel movements/fecal properties, we conducted a double-blind placebo-controlled randomized trial with healthy Japanese volunteers with a tendency for constipation (n = 297). The subjects ingested 2 g/d placebo (okara powder) or test food (Lilac LAB, 1 × 10(8) CFU) once a day for 2 weeks. In the test group of functionally constipated subjects, the changes in the average scores of self-reported fecal size, sensation of incomplete evacuation, and defecation frequency were significantly improved compared to the placebo group (p < 0.05), and fecal color and odor tended to improve (p = 0.07). In the test food group of all subjects and among the non-functionally constipated subjects, the fecal size tended to improve compared to the placebo group (p = 0.06, p = 0.07, respectively). Lilac LAB was effective in improving bowel movements and fecal properties in functionally constipated persons.
authors.affiliation: a Section of Research and Development, Arterio Bio Co., Ltd. , Otaru , Japan.
authors.forename: Kimiko
authors.initials: K
authors.lastname: Minamida
authors.forename: Mie
authors.initials: M
authors.lastname: Nishimura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miwa
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001407:Bacillus / Q000502:physiology*; D003248:Constipation / Q000382:microbiology / Q000503:physiopathology*; D003672:Defecation / Q000187:drug effects* / Q000502:physiology; D004043:Dietary Fiber / Q000494:pharmacology*; D004198:Disease Susceptibility; D005243:Feces / Q000737:chemistry*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D055815:Young Adult
keywords: Bacillus coagulans; constipation; human trial; okara; synbiotics