title: Different immunological mechanisms govern protection from experimental stroke in young and older mice with recombinant TCR ligand therapy.
abstract: Stroke is a leading cause of death and disability in the United States. The lack of clinical success in stroke therapies can be attributed, in part, to inadequate basic research on aging rodents. The current study demonstrates that recombinant TCR ligand therapy uses different immunological mechanisms to protect young and older mice from experimental stroke. In young mice, RTL1000 therapy inhibited splenocyte efflux while reducing frequency of T cells and macrophages in the spleen. Older mice treated with RTL1000 exhibited a significant reduction in inflammatory cells in the brain and inhibition of splenic atrophy. Our data suggest age specific differences in immune response to stroke that allow unique targeting of stroke immunotherapies.
authors.affiliation: Neuroimmunology Research, VA Medical Center Portland, OR, USA ; Department of Neurology, Oregon Health and Science University Portland, OR, USA.
authors.forename: Abby L
authors.initials: AL
authors.lastname: Dotson
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University Portland, OR, USA.
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University Portland, OR, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Libal
authors.affiliation: Department of Neurology, Oregon Health and Science University Portland, OR, USA ; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University Portland, OR, USA ; Knight Cardiovascular Institute, Oregon Health and Science University Portland, OR, USA.
authors.forename: Nabil J
authors.initials: NJ
authors.lastname: Alkayed
authors.affiliation: Neuroimmunology Research, VA Medical Center Portland, OR, USA ; Department of Neurology, Oregon Health and Science University Portland, OR, USA ; Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University Portland, OR, USA.
authors.forename: Halina
authors.initials: H
authors.lastname: Offner
keywords: RTL1000; aging; experimental stroke; immune response; neuroinflammation; therapy