title: Dual-modal imaging and photodynamic therapy using upconversion nanoparticles for tumor cells.
abstract: Here we synthesized silica-coated NaYF4:Yb,Tm@NaGdF4 nanoparticles with hypocrellin photosensitizers covalently incorporated inside the silica shells, combining dual modal imaging and photodynamic therapy (PDT) functions together. Under excitation at 980 nm, the tumor-targeting specificity of the as-prepared nanomaterials efficiently enhanced as folic acid (FA) was conjugated. The internalization of UCNPs@SiO2@hypocrellin A-FA in HeLa cells and HEK-293 cells was observed by confocal microscopy and in vitro magnetic resonance imaging (MRI), which demonstrated that the as-prepared nanocomposites have the ability to target folate receptor (FR) (+) cells. Moreover, magnetic resonance (MR) measurements also demonstrated that the as-prepared nanocomposites could be used as a contrast agent for MRI. All these results showed the feasibility and potential of the as-prepared nanocomposites for simultaneous imaging and PDT application.
authors.affiliation: Key Laboratory of Theoretical and Computational Photochemistry, Ministry of Education, College of Chemistry, Beijing Normal University, 100875, Beijing, P. R. China. jinoyang@bnu.edu.cn.
authors.forename: Chunna
authors.initials: C
authors.lastname: Yang
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Liu
authors.forename: Dacheng
authors.initials: D
authors.lastname: He
authors.forename: Na
authors.initials: N
authors.lastname: Na
authors.forename: Yunling
authors.initials: Y
authors.lastname: Zhao
authors.forename: Jin
authors.initials: J
authors.lastname: Ouyang
mesh_terms: D003287:Contrast Media / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D010569:Perylene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019800:Phenol; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011809:Quinones / Q000627:therapeutic use*; D012822:Silicon Dioxide / Q000737:chemistry; D015019:Yttrium / Q000737:chemistry
chemical_list: D003287:Contrast Media; D017319:Photosensitizing Agents; D011809:Quinones; C525362:sodium yttriumtetrafluoride; D019800:Phenol; D015019:Yttrium; D010569:Perylene; D012822:Silicon Dioxide; D005682:Gadolinium; D005459:Fluorides; C048388:hypocrellin A