title: Palladium- and nickel-catalyzed Kumada cross-coupling reactions of gem-difluoroalkenes and monofluoroalkenes with Grignard reagents.
abstract: A novel Kumada-Tamao-Corriu cross-coupling reaction of gem-di- or monofluoroalkenes with Grignard reagents, with or without β-hydrogen atoms, in the presence of a catalytic amount of palladium- or nickel-based catalysts has been developed. The reaction is performed under mild conditions (room temperature or reflux in diethyl ether for 1-2 h) and leads to di-cross- or mono-cross-coupled products in good to high yields.
authors.affiliation: Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology (ECUST) , Shanghai 200237, China.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Dai
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.forename: Guanyi
authors.initials: G
authors.lastname: Jin
authors.forename: Jingjing
authors.initials: J
authors.lastname: Wu
authors.forename: Song
authors.initials: S
authors.lastname: Cao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D010165:Palladium; D009532:Nickel