title: Pathological assessment of tumor biopsy specimen and surgical sentinel lymph node dissection in patients with melanoma.
abstract: BACKGROUND
  Actual trends of cutaneous malignant melanoma show a faster increase then other forms of cancer. Early detection and diagnosis, and accurate pathologic interpretation of the biopsy specimen is extremely important for the treatment and prognosis of clinically localized melanoma. The surgical approach to cutaneous melanoma patients with clinically uninvolved regional lymph nodes remains controversial.
  
  
  METHODS
  A retrospective study of melanoma cases was conducted in the "Casa Austria" Department of Plastic and Reconstructive Surgery, Emergency County Hospital, Timisoara, Romania. We have analyzed the medical records of 21 patients that underwent surgical treatment for different stages of melanoma in the period 2008-2012. For histopathological diagnosis of melanoma and the sentinel lymph node(s) status, tissular fragments were routinely processed. For the difficult cases, additional immunohistochemical investigation was done.
  
  
  RESULTS
  A positive family history was noted in two cases. The presence of different sizes and localization of pigmented nevi was found in 38% of the cases. Different types of melanoma like superficial spreading melanoma, nodular melanoma or lentigo malignant melanoma and acral lentiginous melanoma was described. The surgical treatment consisted in all cases in wide excision of the primary tumor and prophylactic dissection of sentinel lymph node after lymphoscintigraphy examination. A positive biopsy of the sentinel lymph node was noted in 4.9% of the cases.
  
  
  CONCLUSIONS
  The surgical treatment combining the wide excision of the primary tumor with respect to safe oncological limits with the prophylactic dissection of sentinel lymph node after lymphoscintigraphy examination had the confirmation done by the pathologic interpretation of the biopsy specimen showing that all the patients had a Breslow index more than 1.5 mm.
authors.affiliation: Department of Orthopedics and Trauma, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; lalusha87@yahoo.com.
authors.forename: Gheorghe
authors.initials: G
authors.lastname: Nodiţi
authors.forename: Cristian C
authors.initials: CC
authors.lastname: Nica
authors.forename: Horaţiu Pompiliu
authors.initials: HP
authors.lastname: Petrescu
authors.forename: Codruţ
authors.initials: C
authors.lastname: Ivan
authors.forename: Zorin Petrişor
authors.initials: ZP
authors.lastname: Crăiniceanu
authors.forename: Tiberiu
authors.initials: T
authors.lastname: Bratu
authors.forename: Alis
authors.initials: A
authors.lastname: Dema
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000601:surgery*; D008875:Middle Aged; D010858:Pigmentation; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery*