title: Biomimetic adhesive materials containing cyanoacryl group for medical application.
abstract: For underwater adhesives with biocompatible and more flexible bonds using biomimetic adhesive groups, DOPA-like adhesive molecules were modified with cyanoacrylates to obtain different repeating units and chain length copolymers. The goal of this work is to copy the mechanisms of underwater bonding to create synthetic water-borne underwater medical adhesives through blending of the modified DOPA and a triblock copolymer (PEO-PPO-PEO) for practical application to repair wet living tissues and bones, and in turn, to use the synthetic adhesives to test mechanistic hypotheses about the natural adhesive. The highest values in stress and modulus of the biomimetic adhesives prepared in wet state were 165 kPa and 33 MPa, respectively.
authors.affiliation: Orthopaedic Department, College of Medicine, Chosun University, Gwangju 501-759, Korea. bwjo@chosun.ac.kr.
authors.forename: Sueng Hwan
authors.initials: SH
authors.lastname: Jo
authors.affiliation: College of General Education, Chosun University, Gwangju 501-759, Korea. jss4347@chosun.ac.kr.
authors.forename: Jeong Sun
authors.initials: JS
authors.lastname: Sohn
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000269:Adhesives / Q000737:chemistry*; D040761:Biomimetic Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000737:chemistry*; D004298:Dopamine / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry; D013232:Steel / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000178:Acrylamides; D000269:Adhesives; C116176:PEO-PPO-PEO; D011108:Polymers; D011409:Propylene Glycols; D013232:Steel; D011092:Polyethylene Glycols; C045985:methacrylamide; D004298:Dopamine