title: [Effect of phytic acid and its derivatives on blood lipid peroxidation state in vitro].
abstract: We have studied specific features of lipid peroxidation in whole human blood under the action of aqueous solutions of xymedone (19.6 microM), phytic acid (117.9 microM) and its complex (237.6 microM) synthesized in distilled water and isotonic (0.9%) solution of sodium chloride. The estimated parameters included lipid peroxidation (LPO) rate, total antioxidant potential, superoxide dismutase (SOD) level, and malonic dialdehyde (MDA) level in blood plasma and erythrocytes. It was established that the effect of phytic acid on blood samples includes moderate stimulation of total antioxidant activity and SOD activity with predominant prooxidant effect. The phytic acid--xymedone complex synthesized in distilled water exhibits an antioxidant action, while its synthesis in saline solution yields a prooxidant.
authors.forename: A K
authors.initials: AK
authors.lastname: Martusevich
authors.forename: M V
authors.initials: MV
authors.lastname: Sidorova
authors.forename: N B
authors.initials: NB
authors.lastname: Mel'nikova
authors.forename: A G
authors.initials: AG
authors.lastname: Solov'eva
authors.forename: S P
authors.initials: SP
authors.lastname: Peretiagin
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001773:Blood Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000037:antagonists & inhibitors / Q000378:metabolism; D010084:Oxidation-Reduction; D010833:Phytic Acid / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011743:Pyrimidines; D017382:Reactive Oxygen Species; C069705:xymedon; D008315:Malondialdehyde; D010833:Phytic Acid; D013482:Superoxide Dismutase