title: Lactate is associated with increased 10-day mortality in acute medical patients: a hospital-based cohort study.
abstract: An increased lactate level is related to increased mortality in subpopulations of critically ill patients. The aim of this study was to investigate whether lactate was related to mortality in an emergency department (ED) setting of undifferentiated medical patients. All adult patients admitted from March 2009 to August 2011 to a medical ED with lactate measured within 6 h after arrival were studied. Lactate was stratified into 1-mmol/l intervals and analysed in a multivariate logistic regression analysis. A total of 5317 patients were included, 46.9% men, median age 71 years (5-95% percentiles 25-90 years). The median lactate level was 1.2 mmol/l (5-95% percentiles 0.6-3.8 mmol/l, range 0.2-22 mmol/l). Lactate was associated with 10-day mortality independent of age, comorbidity and presence of hypotension, with an odds ratio of 1.54 (95% confidence interval 1.44-1.63) per 1 mmol/l increase. Lactate is an independent predictor of 10-day mortality among patients admitted to a medical ED.
authors.affiliation: aDepartment of Anesthesia, Lillebaelt Hospital, Kolding bDepartment of Emergency Medicine, Odense University Hospital, Odense cDepartment of Emergency Medicine, Hospital of South West Jutland, Esbjerg, Denmark.
authors.forename: Felix
authors.initials: F
authors.lastname: Haidl
authors.forename: Mikkel
authors.initials: M
authors.lastname: Brabrand
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Henriksen
authors.forename: Annmarie T
authors.initials: AT
authors.lastname: Lassen
mesh_terms: D000208:Acute Disease / Q000401:mortality*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
chemical_list: D019344:Lactic Acid