title: Chiral ammonium betaine-catalyzed highly stereoselective aza-henry reaction of α-aryl nitromethanes with aromatic N-Boc imines.
abstract: A highly stereoselective aza-Henry reaction of α-aryl nitromethanes with aromatic N-Boc imines was established by using C1 -symmetric chiral ammonium betaine as a bifunctional organic base catalyst. Various substituted aryl groups for both imines and nitromethanes were tolerated in the reaction, and a series of precursors for the synthesis of unsymmetrical anti-1,2-diaryl ethylenediamines was provided.
authors.affiliation: Institute of Transformative Bio-Molecules (WPI-ITbM) and Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Nagoya 464-8603 (Japan).
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uraguchi
authors.forename: Keigo
authors.initials: K
authors.lastname: Oyaizu
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Noguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ooi
keywords: asymmetric synthesis; aza-Henry reaction; betaines; organocatalysis; α-aryl nitromethane