title: Adult neuroblastoma complicated by increased intracranial pressure: a case report and review of the literature.
abstract: Neuroblastoma is the third most commonly occurring malignancy of the pediatric population, although it is extremely rare in the adult population. In adults, neuroblastoma is often metastatic and portends an extremely poor overall survival. Our case report documents metastatic neuroblastoma occurring in a healthy 29-year-old woman whose course was complicated by an unusual presentation of elevated intracranial pressures. The patient was treated with systemic chemotherapy, I(131) metaiodobenzylguanidine (MIBG) radiotherapy, and autologous stem cell transplant (SCT). Unfortunately the patient's response to therapy was limited and she subsequently died. We aim to review neuroblastoma in the context of increased intracranial pressure and the limited data of neuroblastoma occurring in the adult population, along with proposed treatment options.
authors.affiliation: Divisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Patrick L
authors.initials: PL
authors.lastname: Stevens
authors.affiliation: Divisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Johnson
authors.affiliation: Department of Pathology, Microbiology, and Immunology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Thompson
authors.affiliation: Divisions of Hematology and Oncology, Department of Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Keedy
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USA.
authors.forename: Haydar A
authors.initials: HA
authors.lastname: Frangoul
authors.affiliation: Division of Pediatric Hematology and Oncology, Department of Pediatrics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University Medical Center 2220 Pierce Avenue, 397 PRB, Nashville, TN 37232-6310, USA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Snyder