title: Cutaneous CD30 positive lymphoproliferative disorders with coexistent epithelial neoplasms: Report of two cases.
abstract: Primary cutaneous large cell anaplastic lymphoma (C-ALCL) and lymphomatoid papulosis (LyP) are cutaneous CD30+ lymphoproliferative disorders (CD30+ LPD). An association with CD30+ LPD and pseudoepitheliomatous hyperplasia has been recognized. Additionally, rare reports of epithelial neoplasms such as keratoacanthomas and squamous cell carcinomas (SCC) occurring in association with both C-ALCL and LyP have been reported. We report two cases of CD30+ LPD with associated epithelial neoplasms; one patient with a primary cutaneous CD30+ LPD and SCC identified within the same lesion, and the other with a keratoacanthoma arising in a lesion of LyP. The pathogenesis of this association is poorly understood although various hypotheses exist. Awareness of the coexistence of these entities will avoid misdiagnosis and incorrect treatment.
authors.affiliation: Department of Dermatology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Kate M
authors.initials: KM
authors.lastname: Newland
authors.affiliation: Department of Dermatology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: McCormack
authors.affiliation: Department of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: H Miles
authors.initials: HM
authors.lastname: Prince
authors.affiliation: Department of Anatomical Pathology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Lade
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D007636:Keratoacanthoma / Q000150:complications / Q000473:pathology*; D017731:Lymphomatoid Papulosis / Q000150:complications / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000150:complications / Q000473:pathology*
keywords: cutaneous CD30+ lymphoproliferative disorder; keratoacanthoma; lymphomatoid papulosis; primary cutaneous large cell anaplastic lymphoma; pseudoepitheliomatous hyperplasia