title: A medicinal herb-based natural health product improves the condition of a canine natural osteoarthritis model: a randomized placebo-controlled trial.
abstract: An oral herb-based natural health product (NHP) was evaluated in the canine natural osteoarthritis model. At baseline, the peak vertical force (PVF, primary endpoint) and case-specific outcome measure of disability (CSOM) were recorded in privately-owned dogs. Dogs (16/group) were randomized to receive NHP formulations or a negative control. The PVF was measured at week (W) 4 and W8. Daily locomotor activity was recorded using accelerometer. The CSOMs were assessed bi-weekly by the owner. The NHP-treated dogs (n = 13) had higher PVF at W4 (p = 0.020) and W8 (p <0.001) when compared to baseline. The changes at W8 were higher than control dogs (n = 14, p <0.027) and consistent with Cohen's d effect size of 0.7 (95% confidence interval: 0.0-1.5). The NHP-treated dogs had higher locomotor activity at W8 (p = 0.025) when compared to baseline. No significant change was observed for the CSOM. The NHP improved the clinical signs of osteoarthritis in this model.
authors.affiliation: Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
authors.forename: Maxim
authors.initials: M
authors.lastname: Moreau
authors.affiliation: Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lussier
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Pelletier
authors.affiliation: Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
authors.forename: Johanne
authors.initials: J
authors.lastname: Martel-Pelletier
authors.affiliation: Department of Pathology and Microbiology - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Bédard
authors.affiliation: Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.
authors.forename: Dominique
authors.initials: D
authors.lastname: Gauvin
authors.affiliation: Research Group in Animal Pharmacology of Quebec (GREPAQ), Department of Veterinary Biomedical Sciences - Faculty of Veterinary Medicine, Université de Montréal, P.O. Box 5000, Saint-Hyacinthe, Quebec J2S 7C6, Canada; Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Tour Viger, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada. Electronic address: eric.troncy@umontreal.ca.
authors.forename: Eric
authors.initials: E
authors.lastname: Troncy
mesh_terms: D000704:Analysis of Variance; D031230:Ananas / Q000737:chemistry; D000818:Animals; D029743:Boswellia / Q000737:chemistry; D030024:Curcuma / Q000737:chemistry; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology*; D004285:Dogs; D031684:Harpagophytum / Q000737:chemistry; D008124:Locomotion / Q000187:drug effects; D010003:Osteoarthritis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008517:Phytotherapy / Q000379:methods / Q000662:veterinary*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D031965:Ribes / Q000737:chemistry; D032108:Salix / Q000737:chemistry; D020903:Tanacetum parthenium / Q000737:chemistry; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts
keywords: Canine model; Force platform; Locomotor activity; Naturally-occurring osteoarthritis; Phytochemical compounds