title: An analysis of expectant management in women with early-onset preeclampsia in China.
abstract: Preeclampsia is a pregnancy-specific disorder and a leading cause of morbidity and mortality in both women and fetus. Although women with early severe preeclampsia are generally considered to require expedious delivery, expectant management may benefit for pregnancy prolongation. We performed a retrospective analysis of expectant management in early-onset preeclampsia, with or without fetal grow restriction (FGR) over a 6-year period, to investigate whether these women benefit from expectant management. Data including clinical parameters and liver and renal function from 186 nulliparous women with early-onset preeclampsia were analysed. In women with early-onset preeclampsia, 76.8% were delivered after 48 h and the median pregnancy prolongation was 8 days, whereas 23.2% were delivered within 48 h. There was no difference in maternal parameters, liver or renal functions between women in these two groups, regardless of the severity of preeclampsia. However, the stillbirth number was higher in preeclamptic women delivered after 48 h compared with those delivered within 48 h. Our study demonstrates that the decision for immediate delivery or expectant management was not associated with clinical parameter or laboratory biomarker of liver and renal function. However, the risk of stillbirth should still be taken into consideration when making the decision for immediate delivery or expectant management in the clinic.
authors.affiliation: The Hospital of Obstetrics & Gynaecology, Fudan University, Wuxi, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.affiliation: The Hospital of Obstetrics & Gynaecology, Fudan University, Wuxi, China.
authors.forename: F
authors.initials: F
authors.lastname: Shen
authors.affiliation: The Hospital of Obstetrics & Gynaecology, Fudan University, Wuxi, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Gao
authors.affiliation: Wuxi Maternity and Children Health Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: M
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005313:Fetal Death; D006801:Humans; D008875:Middle Aged; D011225:Pre-Eclampsia / Q000628:therapy*; D011247:Pregnancy; D012189:Retrospective Studies