title: Phenolic constituents from the aerial parts of Glycyrrhiza inflata and their antibacterial activities.
abstract: Chemical investigation on 90% ethanol extracts of the aerial parts of Glycyrrhiza inflata afforded two new phenolic constituents, 2-(3-methyl-2-butenyl)-3,5,4'-trihydroxy-bibenzyl (1) and (2S)-6-[(E)-3-hydroxymethyl-2-butenyl]-3',4',5,7-tetrahydroxy-dihydroflavanone (2) along with seven known dihydroflavanones (3-9). Compounds 1-9 were tested for their minimum inhibitory concentration (MIC) values of inhibiting Staphylococcus aureus and Staphylococcus epidermidis. Compound 1 showed moderate antibacterial activities against both S. aureus (MIC of 50.00 μg/ml) and S. epidermidis (MIC of 12.50 μg/ml). The analysis of structure-activity relationships revealed that the antibacterial activity of dihydroflavanones (2-9) was significantly affected by the position of prenyl group.
authors.affiliation: a Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin of Xinjiang Production & Construction Group , College of Life Science, Tarim University , Alar 843300 , China.
authors.forename: Biao
authors.initials: B
authors.lastname: Zhou
authors.forename: Chuan-Xing
authors.initials: CX
authors.lastname: Wan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls; D044950:Flavanones; D006035:Glycyrrhiza / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry; D035261:Plant Components, Aerial / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: C000598448:(2S)-6-((E)-3-hydroxymethyl-2-butenyl)-3',4',5,7-tetrahydroxy-dihydroflavanone; C000598447:2-(3-methyl-2-butenyl)-3,5,4'-trihydroxy-bibenzyl; D000900:Anti-Bacterial Agents; D001632:Bibenzyls; D044950:Flavanones; D010636:Phenols
keywords: Glycyrrhiza inflata; antibacterial activity; phenolic constituents