title: Inflammasomes and the microbiota--partners in the preservation of mucosal homeostasis.
abstract: Inflammasomes are multiprotein complexes that serve as signaling platforms initiating innate immune responses. These structures are assembled upon a large array of stimuli, sensing both microbial products and endogenous signals indicating loss of cellular homeostasis. As such, inflammasomes are regarded as sensors of cellular integrity and tissue health, which, upon disruption of homeostasis, provoke an inflammatory response by the release of potent cytokines. Recent evidence suggests that in addition to sensing cellular integrity, inflammasomes are involved in the homeostatic mutualism between the host and its indigenous microbiota. Here, we summarize the involvement of various inflammasomes in host-microbiota interactions and focus on the role of commensal as well as pathogenic bacteria in inflammasome signaling.
authors.affiliation: Immunology Department, Weizmann Institute of Science, 100 Herzl Street, 76100, Rehovot, Israel.
authors.forename: Maayan
authors.initials: M
authors.lastname: Levy
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Thaiss
authors.forename: Meirav N
authors.initials: MN
authors.lastname: Katz
authors.forename: Jotham
authors.initials: J
authors.lastname: Suez
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
mesh_terms: D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D064307:Microbiota / Q000276:immunology*; D013559:Symbiosis / Q000276:immunology*
chemical_list: D058847:Inflammasomes