title: Swine interferon-inducible transmembrane proteins potently inhibit influenza A virus replication.
abstract: Human interferon-inducible transmembrane proteins (IFITMs) were identified as restriction factors of influenza A virus (IAV). Given the important role of pigs in the zoonotic cycle of IAV, we cloned swine IFITMs (swIFITMs) and found two IFITM1-like proteins, one homologue of IFITM2, and a homologue of IFITM3. We show that swIFITM2 and swIFITM3 localize to endosomes and display potent antiviral activities. Knockdown of swIFITMs strongly reduced virus inhibition by interferon, establishing the swIFITMs as potent restriction factors in porcine cells.
authors.affiliation: Institute of Medical Virology, University of Zurich, Zurich, Switzerland Life Sciences Zurich Graduate School, ETH and University of Zurich, Zurich, Switzerland.
authors.forename: Caroline
authors.initials: C
authors.lastname: Lanz
authors.affiliation: Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
authors.forename: Emilio
authors.initials: E
authors.lastname: Yángüez
authors.affiliation: Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
authors.forename: Dario
authors.initials: D
authors.lastname: Andenmatten
authors.affiliation: Institute of Medical Virology, University of Zurich, Zurich, Switzerland stertz.silke@virology.uzh.ch.
authors.forename: Silke
authors.initials: S
authors.lastname: Stertz
mesh_terms: D000818:Animals; D002460:Cell Line; D011992:Endosomes / Q000737:chemistry; D009980:Influenza A virus / Q000276:immunology* / Q000502:physiology*; D007372:Interferons / Q000276:immunology*; D008565:Membrane Proteins / Q000032:analysis / Q000276:immunology*; D013552:Swine; D014779:Virus Replication
chemical_list: D008565:Membrane Proteins; D007372:Interferons