title: Nickel-catalyzed α-arylation of zinc enolates with polyfluoroarenes via C-F bond activation under neutral conditions.
abstract: The first nickel-catalyzed α-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated α-aryl carboxylic acids and α-aryl amides that are important intermediates for drug discovery.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Daohong
authors.initials: D
authors.lastname: Yu
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Wang
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
authors.forename: Long
authors.initials: L
authors.lastname: Lu
mesh_terms: D000577:Amides / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D004987:Ethers / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry*
chemical_list: C000594753:2-(polyfluorophenyl)pyridine; D000577:Amides; D002264:Carboxylic Acids; D004952:Esters; D004987:Ethers; D006845:Hydrocarbons, Fluorinated; D011725:Pyridines; D009532:Nickel; D015032:Zinc