title: Pathological profile of patients with breast diseases in Shiraz.
abstract: BACKGROUND
  Around 200,000 breast disorders are annually diagnosed all over the world. Fibrocystic changes are the most common breast disorder and fibroadenoma is the most prevalent benign breast tumor. The present study aimed to determine the spectrum, type and prevalence of breast masses in women referred to Shiraz University of Medical Sciences between 2004 and 2012 .
  
  
  METHODS
  A cross-sectional study was conducted on the diagnostic reports data.
  
  
  RESULTS
  A total of 640 samples were studied. Most 57.3% of masses were detected in the left breast, 65%, 28.2% and 6.1% of cases presenting with benign, malignant, and inflammatory lesions, respectively. Among all the samples the most prevalent diagnosis (37.7%) was fibroadenoma and fibrocystic lesions (17%). 174 samples (96% of the malignant cases) were invasive. 6.5% of the benign, and 37% of the malignant cases occurred in post menopause women and the differences were statistically significant. Among those with malignant tumors lymph nodes were involved in 25.6% of menopausal women and 44.2% of non-menopausal ones, and the difference was statistically significant.
  
  
  CONCLUSIONS
  Regular clinical breast examination beside mammographic follow-ups, especially during menopause, should be carried out as a priority and a national organized program should be designed for screening breast disorders.
authors.affiliation: Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran E-mail : Tahmasebikh@gmail.com.
authors.forename: Abbas
authors.initials: A
authors.lastname: Rezaianzadeh
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Sepandi
authors.forename: Majid
authors.initials: M
authors.lastname: Akrami
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Tabatabaee
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Rajaeefard
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Tahmasebi
authors.forename: Abdolrasoul
authors.initials: A
authors.lastname: Talei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D018226:Fibroadenoma / Q000473:pathology*; D005348:Fibrocystic Breast Disease / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010212:Papilloma / Q000473:pathology*; D011379:Prognosis; D055815:Young Adult