title: Multifunctional material based on ionic transition metal complexes and gold-silica nanoparticles: synthesis and photophysical characterization for application in imaging and therapy.
abstract: A new combination of luminescent ionic transition-metal complexes (M = Ru(II) or Ir(III)) with gold silica-based nanoparticles (GSNPs) gives a promising nanomaterial for application in biomedical fields. Herein we report the synthesis and the photophysical properties of Ru(II) and Ir(III) complexes doped gold core-polysiloxane shell particles prepared by microemulsion method and characterized by Transmission Electron Microscopy, Dynamic Light Scattering and UV-Vis spectroscopy. The cytotoxicity and photodynamic activity of the obtained 50 nm-diameter nanoparticles were evaluated in vitro, providing noteworthy results. Furthermore, their intrinsic phosphorescence allows the localization of the photosensitizing nanoparticles into the cytosol of tumor cells by fluorescence confocal microscope. These valuable features designate them as multifunctional nanoplatforms for theranostic purposes.
authors.forename: Loredana
authors.initials: L
authors.lastname: Ricciardi
authors.forename: Matteo
authors.initials: M
authors.lastname: Martini
authors.forename: Olivier
authors.initials: O
authors.lastname: Tillement
authors.forename: Lucie
authors.initials: L
authors.lastname: Sancey
authors.forename: Pascal
authors.initials: P
authors.lastname: Perriat
authors.forename: Mauro
authors.initials: M
authors.lastname: Ghedini
authors.forename: Elisabeta I
authors.initials: EI
authors.lastname: Szerb
authors.forename: Yogesh J
authors.initials: YJ
authors.lastname: Yadav
authors.forename: Massimo
authors.initials: M
authors.lastname: La Deda
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D006046:Gold; D007495:Iridium / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry / Q000627:therapeutic use*; D010316:Particle Size; D012428:Ruthenium / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D007495:Iridium; D006046:Gold; D012822:Silicon Dioxide; D012428:Ruthenium