title: Hepatosplenic T cell lymphoma.
abstract: A 26 year old lady came with intermittent fever since eight months. She also complained of abdominal pain and decreased appetite for six months. She had swelling of feet and distension of abdomen due to ascites since one month. There was history of jaundice one month back. On radiological examination, hepatomegaly with dilated portal vein, massive splenomegaly and ascites without any lymphadenopathy was noted. Chest X-ray was normal. Blood examination and bone marrow studies were inconclusive. We received her liver biopsy, which showed normal architecture and sinusoidal infiltration by a monomorphic population of small to intermediate sized lymphoid cells. Portal tracts were free of such infiltrate. These lymphoid cells were LCA, CD3, CD43 positive and negative for CD20, CD34, CD4, CD8 and c-kit. Based on all these features, a diagnosis of Hepatosplenic T cell lymphoma was made. She was treated symptomatically, however she died within two months of diagnosis.
authors.affiliation: Department of Pathology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.
authors.forename: Nadeem Noor Mohammad
authors.initials: NN
authors.lastname: Khan
authors.affiliation: Department of Hematology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.
authors.forename: Farah F
authors.initials: FF
authors.lastname: Jijina
authors.affiliation: Department of Pathology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.
authors.forename: Amita S
authors.initials: AS
authors.lastname: Joshi
authors.affiliation: Department of Pathology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.
authors.forename: Prajakta A
authors.initials: PA
authors.lastname: Gupte
authors.affiliation: Department of Pathology, Seth GSMC & KEM Hospital, Parel, Mumbai, 22 Maharashtra India.
authors.forename: Rachana A
authors.initials: RA
authors.lastname: Chaturvedi
keywords: Hepatosplenic; Lymphoma; T cell