title: Therapeutic opportunities for targeting cold pain pathways.
abstract: Cold pain is a frequent symptom in neuropathic pain. Compared to other pain modalities, such as heat pain, the mechanisms behind physiological and pathological cold pain remain elusive. Moreover, it is becoming increasingly evident that cold pain pharmacology differs between various neuropathic pain conditions, making mechanism-directed treatment based on an understanding of the underlying pathophysiological mechanisms imperative to achieving clinical success. Here we review the processes of physiological and abnormal cold sensing, the pharmacology of cold nociception, cold hyperalgesia and cold allodynia, and provide an overview of cold pain syndromes and their current and potential treatments.
authors.affiliation: Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Yin
authors.affiliation: Department of Physiology and Pathophysiology and Department of Anesthesiology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Zimmermann
authors.affiliation: Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, Queensland 4102, Australia.
authors.forename: Irina
authors.initials: I
authors.lastname: Vetter
authors.affiliation: Institute for Molecular Biosciences, The University of Queensland, St Lucia, Queensland 4072, Australia. Electronic address: r.lewis@imb.uq.edu.au.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lewis
mesh_terms: D000818:Animals; D003080:Cold Temperature / Q000009:adverse effects*; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D059226:Nociceptive Pain / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D026941:Sodium Channel Blockers / Q000008:administration & dosage; D050051:Transient Receptor Potential Channels / Q000037:antagonists & inhibitors / Q000378:metabolism; D061566:Voltage-Gated Sodium Channels / Q000378:metabolism
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D026941:Sodium Channel Blockers; D050051:Transient Receptor Potential Channels; D061566:Voltage-Gated Sodium Channels
keywords: Cold pain sensitisation; Cold pain signalling; Ion channels; Pain pathways; TRP channels; Treatment