title: Tissue engineering of oral mucosa: a shared concept with skin.
abstract: Tissue-engineered oral mucosa, in the form of epithelial cell sheets or full-thickness oral mucosa equivalents, is a potential solution for many patients with congenital defects or with tissue loss due to diseases or tumor excision following a craniofacial cancer diagnosis. In the laboratory, it further serves as an in vitro model, alternative to in vivo testing of oral care products, and provides insight into the behavior of the oral mucosal cells in healthy and pathological tissues. This review covers the old and new generation scaffold types and materials used in oral mucosa engineering; discusses similarities and differences between oral mucosa and skin, the methods developed to reconstruct oral mucosal defects; and ends with future perspectives on oral mucosa engineering.
authors.affiliation: Department of Medical Biology, School of Medicine, Acibadem University, 34742, Istanbul, Turkey, beste.kinikoglu@acibadem.edu.tr.
authors.forename: Beste
authors.initials: B
authors.lastname: Kinikoglu
authors.forename: Odile
authors.initials: O
authors.lastname: Damour
authors.forename: Vasif
authors.initials: V
authors.lastname: Hasirci
mesh_terms: D004847:Epithelial Cells / Q000166:cytology; D006801:Humans; D009061:Mouth Mucosa / Q000166:cytology*; D019651:Plastic Surgery Procedures; D012867:Skin / Q000166:cytology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds