title: Lack of prognostic significance of SOCS-1 expression in colorectal adenocarcinomas.
abstract: BACKGROUND
  Recent studies have indicated that down-regulation of the suppressor of cytokine signaling-1 (SOCS-1) gene results in tumor formation and that SOCS-1 acts as a tumor suppressor gene. SOCS-1 has been also suggested to function as a tumor suppressor with colorectal cancer.
  
  
  OBJECTIVE
  In the present study, we aimed to determine the association of SOCS-1 expression in colorectal cancer tissues with clinicopathologic characteristics immunohistochemically and also to identify its prognostic significance.
  
  
  METHODS
  SOCS-1 expression was studied immunohistochemically in 67 patients diagnosed with resected colorectal carcinomas and 30 control subjects.
  
  
  RESULTS
  SOCS-1 expression was found in 46.3% of tumor tissues and 46.7% of the control group. Statistical analyses did not establish any significant association between SOCS-1 expression and clinicopathologic characteristics. Also, no significant association with SOCS-1 expression was found using progression-free survival and overall survival analyses (p=0.326 and p=0.360, respectively).
  
  
  CONCLUSIONS
  Our results show that SOCS-1 has no prognostic significance in colorectal cancer.
authors.affiliation: Department of Gastroenterology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey E-mail : talatayy@gmail.com.
authors.forename: Talat
authors.initials: T
authors.lastname: Ayyildiz
authors.forename: Enver
authors.initials: E
authors.lastname: Dolar
authors.forename: Saduman Balaban
authors.initials: SB
authors.lastname: Adim
authors.forename: Ahmet Tarik
authors.initials: AT
authors.lastname: Eminler
authors.forename: Omer
authors.initials: O
authors.lastname: Yerci
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins