title: O-GlcNAc and the epigenetic regulation of gene expression.
abstract: O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator. The enzymes of O-GlcNAc cycling, OGT and O-GlcNAcase, act in mitochondria, the cytoplasm, and the nucleus in association with epigenetic "writers" and "erasers" of the histone code. Both O-GlcNAc and O-phosphate modify repeats within the RNA polymerase II C-terminal domain (CTD). By communicating with the histone and CTD codes, O-GlcNAc cycling provides a link between cellular metabolic status and the epigenetic machinery. Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inheritance.
authors.affiliation: From the NCI and lewisbri@mail.nih.gov.
authors.forename: Brian A
authors.initials: BA
authors.lastname: Lewis
authors.affiliation: NIDDK, National Institutes of Health, Bethesda, Maryland 20892 jah@helix.nih.gov.
authors.forename: John A
authors.initials: JA
authors.lastname: Hanover
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism; D012319:RNA Polymerase II / Q000737:chemistry / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D006657:Histones; D017351:N-Acetylglucosaminyltransferases; D012319:RNA Polymerase II; C110628:hexosaminidase C; D001619:beta-N-Acetylhexosaminidases; D000117:Acetylglucosamine
keywords: Epigenetics; Glycobiology; Histones; O-GlcNAc; O-GlcNAcylation; Polycomb; RNA Polymerase II; Signaling; Transcription