title: Combination of Er:YAG laser and CO2 laser treatment on skin tissue.
abstract: Skin is the most important organ in our body, as it protects us from external environmental effects. Study the ability of the skin to stretch and the histological examinations of irradiated tissues have significant values in scientific and medical applications. Only a few studies have been done to study the correlation between epidermis ablation and the changes that occur at dermal levels when using dual lasers in ablative resurfacing mode. The aim of this work is to determine this correlation and to estimate the effects of multiple pulses on induced collagen remodeling and the strength of skin exposed with dual lasers in an in vivo rat model. All laser exposures led to mark improvement in the skin's strength compared to their own controls. The histological investigation indicated that there was a thickness loss in the epidermis layer with the induction of deep collagen coagulation in the dermis layer as the dual laser pulses increased. Additionally, more collagen fibers were remolded in the treated samples by dual wavelengths. We conclude that by combining dual lasers with multiple pulses targeted at not only the epidermis layer of the skin, it could also induce some heat diffusion in the dermis layer which causes more coagulation of collagen fibers. The tensile results confirmed by our histological data demonstrate that the strength of irradiated skin with dual wavelengths increased more than using both lasers separately on the skin tissue since more collagen is induced.
authors.affiliation: Advanced Photonic Science Institute, Faculty of Science, Universiti Teknologi Malaysia, Skudai, Johor, Malaysia.
authors.forename: Sana Mohammed
authors.initials: SM
authors.lastname: Anayb Baleg
authors.forename: Noriah
authors.initials: N
authors.lastname: Bidin
authors.forename: Lau Pik
authors.initials: LP
authors.lastname: Suan
authors.forename: Muhammad Fakarruddin
authors.initials: MF
authors.lastname: Sidi Ahmad
authors.forename: Ganesan
authors.initials: G
authors.lastname: Krishnan
authors.forename: Abd Rahman
authors.initials: AR
authors.lastname: Johari
authors.forename: Asmah
authors.initials: A
authors.lastname: Hamid
mesh_terms: D000818:Animals; D053685:Laser Therapy; D008297:Male; D051381:Rats; D015595:Skin Aging