title: Enzymatic aerobic ring rearrangement of optically active furylcarbinols.
abstract: Biogenic furans are currently discussed as highly attractive alternative feedstock in a post-fossil society; thus, also the creation of sustainable furan valorization pathways appears of great importance. Here an artificial Achmatowicz monooxygenase activity for the aerobic ring expansion of furans is achieved by the combination of commercial glucose oxidase as oxygen-activating biocatalyst and wild-type chloroperoxidase as oxygen-transfer mediator, providing a biological ready-to-use solution for this truly synthetic furan rearrangement. In concert with enzymatic transformations for the enantioselective preparation of optically active furylcarbinols, purely biocatalytic reaction cascades for the stereocontrolled construction of complex pyranones are obtained, exhibiting high functional group tolerance even to oxidation-sensitive moieties.
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 4, 50939 Cologne, Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Thiel
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 4, 50939 Cologne, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Doknić
authors.affiliation: Department für Chemie, Universität zu Köln, Greinstrasse 4, 50939 Cologne, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Deska
mesh_terms: D055162:Biocatalysis; D002711:Chloride Peroxidase / Q000737:chemistry; D005663:Furans / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D005949:Glucose Oxidase / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D006899:Mixed Function Oxygenases / Q000737:chemistry; D055095:Optics and Photonics; D009930:Organic Chemicals; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D009195:Peroxidase / Q000737:chemistry
chemical_list: D005663:Furans; D009930:Organic Chemicals; D006899:Mixed Function Oxygenases; D005949:Glucose Oxidase; D002711:Chloride Peroxidase; D009195:Peroxidase; D005947:Glucose; D010100:Oxygen; C039281:furan