title: [The blood leptin and the activity of the system inflammatory response in patients with diabetes mellitus type 2 with different body weight and disease duration].
abstract: Recent studies focused on the adipose tissue hormones role, especially leptin as one of the basic and generalized nonspecific inflammation markers among them. Some of the major markers are IL-2, IL -6 and TNF-alpha in the pathogenesis of diabetes (DM) and its complications. It is established that patients with type 2 diabetes lasting from 5 to 10 years represent the highest leptin and cytokines levels, and during this period cardiovascular complications of type 2 diabetes are formed. Also it is found that the leptin level was significantly lower in patients with normal body weight, while the levels of IL-6 and TNF-a are the highest in these patients. Obviously, the increased level of these cytokines helps to maintain a normal body weight in these patients. Despite the fact that type 2 diabetes is considered a non-autoimmune disease, it is known that for a long glucose toxicity and lipotoxicity metabolic immunosuppression occurs, which causes changes in T-cell immunity, and consequently to autoimmunity.
authors.forename: B M
authors.initials: BM
authors.lastname: Man'kovs'kyĭ
authors.forename: A M
authors.initials: AM
authors.lastname: Urbanovych
mesh_terms: D000273:Adipose Tissue / Q000276:immunology; D001835:Body Weight; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood / Q000276:immunology; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000276:immunology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000276:immunology
chemical_list: D016207:Cytokines; C508600:IL6 protein, human; D007376:Interleukin-2; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha