title: Efficacy of active carbon towards the absorption of deoxynivalenol in pigs.
abstract: In order to assess the in vivo efficacy of mycotoxin binders, specific toxicokinetic parameters should be measured according to European guidelines. For this purpose, an absorption model in pigs is described with emphasis on absorption kinetics. Pigs received a single oral bolus of the mycotoxin deoxynivalenol alone or in combination with active carbon (applied as mycotoxin binder). After administration of deoxynivalenol alone, significant plasma amounts of deoxynivalenol were detected and kinetic parameters were calculated using a one compartmental model. Activated carbon completely prevented the absorption of deoxynivalenol as no plasma amounts could be detected.
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. mathias.devreese@ugent.be.
authors.forename: Mathias
authors.initials: M
authors.lastname: Devreese
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. gunther.antonissen@ugent.be.
authors.forename: Gunther
authors.initials: G
authors.lastname: Antonissen
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. patrick.debacker@ugent.be.
authors.forename: Patrick
authors.initials: P
authors.lastname: De Backer
authors.affiliation: Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. siska.croubels@ugent.be.
authors.forename: Siska
authors.initials: S
authors.lastname: Croubels
mesh_terms: D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D008297:Male; D013552:Swine; D014255:Trichothecenes / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D014255:Trichothecenes; D002606:Charcoal; C007262:deoxynivalenol