title: Serum adipokine concentrations in dogs with acute pancreatitis.
abstract: BACKGROUND
  Limited information is available about the role of adipokines in the development and progression of acute pancreatitis (AP) in dogs.
  
  
  OBJECTIVE
  To determine whether the circulating concentrations of adipokines differed between healthy dogs and dogs with AP, and whether the circulating concentrations differed between AP survivors and AP nonsurvivors.
  
  
  METHODS
  Twenty-eight healthy dogs and 25 client-owned dogs with AP.
  
  
  METHODS
  Prospective observational cohort study of 25 client-owned dogs with newly diagnosed AP and 28 otherwise healthy dogs with similar body condition scores. The serum concentrations of leptin, adiponectin, resistin, visfatin, interleukin (IL)-1β, IL-6, IL-10, IL-18, and tumor necrosis factor (TNF)-α were measured.
  
  
  RESULTS
  The serum concentrations of leptin (P = .0021), resistin (P = .0010), visfatin (P < .0001), IL-1β (P < .0001), IL-6 (P = .0002), IL-10 (P < .0001), and IL-18 (P < .0001) were significantly higher in dogs with AP than healthy dogs, whereas the adiponectin concentration (P = .0011) was significantly lower. There were significant differences in the serum concentrations of leptin (P = .028) and adiponectin (P = .046) in survivors and nonsurvivors. After the disappearance of clinical signs, the concentrations of resistin (P = .037) and IL-1β (P = .027) decreased significantly, whereas the serum concentrations of leptin (P > .999), adiponectin (P = .11), visfatin (P = .83), IL-6 (P = .82), IL-10 (P = .82), IL-18 (P = .56), and TNF-α (P = .94) did not differ significantly.
  
  
  CONCLUSIONS
  This study showed that dysregulation of adipokines might be involved in the pathogenesis of AP. In addition, leptin and adiponectin are likely to be associated with mortality rate in AP.
authors.affiliation: Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, Korea.
authors.forename: J
authors.initials: J
authors.lastname: Paek
authors.forename: J-H
authors.initials: JH
authors.lastname: Kang
authors.forename: H-S
authors.initials: HS
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Lee
authors.forename: K W
authors.initials: KW
authors.lastname: Seo
authors.forename: M-P
authors.initials: MP
authors.lastname: Yang
mesh_terms: D000208:Acute Disease; D054392:Adipokines / Q000097:blood*; D000818:Animals; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood* / Q000401:mortality; D004285:Dogs / Q000097:blood; D005260:Female; D016753:Interleukin-10 / Q000097:blood; D020382:Interleukin-18 / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D010195:Pancreatitis / Q000097:blood / Q000401:mortality / Q000662:veterinary*; D011446:Prospective Studies; D052243:Resistin / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D020382:Interleukin-18; D053583:Interleukin-1beta; D015850:Interleukin-6; D020738:Leptin; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Adiponectin; Canine; Cytokine; Leptin; Resistin; Visfatin