title: Relation of serum adiponectin levels and obesity with breast cancer: a Japanese case-control study.
abstract: BACKGROUND
  It is known that obesity is one of the risk factors for breast cancer although the association may differ between ethnic groups and with the menopausal status. Recently obesity-related risk factors including serum adiponectin and insulin levels have been analyzed together with BMI in association with breast cancer risk.
  
  
  METHODS
  We measured serum high molecular weight (HMW) adiponectin and insulin levels in a hospital based case-control study, including 66 sets of Japanese female breast cancer cases and age and menopausal status matched controls. Serum levels of HMW adiponectin, insulin levels and body mass index (BMI) were examined in association with breast cancer risk with adjustment for the various known risk factors by menopausal status.
  
  
  RESULTS
  Women in the highest HMW adiponectin levels showed significant reduced risk of breast cancer in both pre and postmenopausal women (odds ratio (OR), 0.01; 95% confidence interval (CI), 0.00-0.26 and 0.13; 0.03-0.57, respectively). Lower BMI showed decreased breast cancer risk in both pre and postmenopausal women (OR, 0.04; 95% CI, 0.00-0.69, OR, 0.28; 95% CI, 0.07-1.11, respectively).
  
  
  CONCLUSIONS
  These results indicated that higher serum HMW adiponectin levels and lower BMI are associated with a decreased breast cancer risk in both pre and postmenopausal women in Japan, adding evidence for the obesity link.
authors.affiliation: Department of Public Health, Sapporo Medical University School of Medicine, Sapporo, Japan E-mail : m.minatoya@sapmed.ac.jp.
authors.forename: Machiko
authors.initials: M
authors.lastname: Minatoya
authors.forename: Goro
authors.initials: G
authors.lastname: Kutomi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shima
authors.forename: Sumiyo
authors.initials: S
authors.lastname: Asakura
authors.forename: Seiko
authors.initials: S
authors.lastname: Otokozawa
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akasaka
authors.forename: Tetsuji
authors.initials: T
authors.lastname: Miura
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Mori
authors.forename: Koichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D016017:Odds Ratio; D017698:Postmenopause; D017697:Premenopause; D011379:Prognosis; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D014408:Biomarkers, Tumor