title: Inferior Vena Cava Oxygen Saturation during the First Three Postnatal Days in Preterm Newborns with and without Patent Ductus Arteriosus.
abstract: BACKGROUND
  Inferior vena cava (IVC) oxygen saturation as an indicator of mixed venous oxygenation may be valuable for understanding postnatal adaptations in newborn infants. It is unknown how this parameter progresses in critically ill premature infants.
  
  
  OBJECTIVE
  To investigate IVC oxygen saturation during the first three days of life in preterm infants with and without patent ductus arteriosus (PDA).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Twenty-seven preterm infants were admitted to the Neonatal Intensive Care. Preterm infants with umbilical venous catheterization were included in the study. Six umbilical venous blood gas values were obtained from each infant during the first 72 hours of life. Preterm infants in the study were divided into two groups. Haemodynamically significant PDA was diagnosed by echocardiography in 11 (41%) infants before the 72(nd) hour of life in the study group and ibuprofen treatment was started, whereas 16 (59%) infants who didn't have haemodynamically significant PDA were included in the control group.
  
  
  RESULTS
  In the entire group, the highest value of mean IVC oxygen saturation was 79.9% at the first measurement and the lowest was 64.8% at the 72(nd) hour. Inferior vena cava oxygen saturations were significantly different between the study and control groups. Post-hoc analysis revealed that the first and 36(th) hour measurements made the difference (p=0.01).
  
  
  CONCLUSIONS
  Inferior vena cava oxygen saturation was found to be significantly different between preterm infants with and without PDA. Further studies are needed to understand the effect of foetal shunts on venous oxygenation during postnatal adaptation in newborn infants.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ece
authors.initials: E
authors.lastname: Yapakçı
authors.affiliation: Division of Neonatology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Ecevit
authors.affiliation: Division of Neonatology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Deniz Anuk
authors.initials: DA
authors.lastname: Ince
authors.affiliation: Division of Cardiology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Gökdemir
authors.affiliation: Department of Biostatistics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: M Agah
authors.initials: MA
authors.lastname: Tekindal
authors.affiliation: Division of Neonatology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Hande
authors.initials: H
authors.lastname: Gülcan
authors.affiliation: Division of Neonatology, Department of Pediatrics, Başkent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Tarcan
keywords: Inferior vena cava oxygen saturation; mixed venous oxygen saturation; patent ductus arteriosus; prematurity