title: Reduced retention of Pittsburgh compound B in white matter lesions.
abstract: OBJECTIVE
  One of the interesting features of the amyloid tracer Pittsburgh compound B (PiB) is that it generates a signal in the white matter (WM) in both healthy subjects and cognitively impaired individuals. This characteristic gave rise to the possibility that PiB could be used to trace WM pathology. In a group of cognitively healthy elderly we examined PiB retention in normal-appearing WM (NAWM) and WM lesions (WML), one of the most common brain pathologies in aging.
  
  
  METHODS
  We segmented WML and NAWM on fluid attenuation inversion recovery (FLAIR) images of 73 subjects (age 61.9 ± 10.0, 71 % women). PiB PET images were corrected for partial volume effects and coregistered to FLAIR images and WM masks. WML and NAWM PiB signals were then extracted.
  
  
  RESULTS
  PiB retention in WML was lower than in NAWM (p < 0.001, 14.6 % reduction). This was true both for periventricular WML (p < 0.001, 17.8 % reduction) and deep WML (p = 0.001, 7.5 % reduction).
  
  
  CONCLUSIONS
  PiB binding in WM is influenced by the presence of WML, which lower the signal. Our findings add to the growing evidence that PiB can depict WM pathology and should prompt further investigations into PiB binding targets in WM.
authors.affiliation: Center for Brain Health, Department of Psychiatry, New York University School of Medicine, 145 East 32nd Street, New York, NY, 10016, USA, Lidia.Glodzik@nyumc.org.
authors.forename: Lidia
authors.initials: L
authors.lastname: Glodzik
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.forename: Jinyu
authors.initials: J
authors.lastname: Li
authors.forename: Cyrus
authors.initials: C
authors.lastname: Zhou
authors.forename: Wai
authors.initials: W
authors.lastname: Tsui
authors.forename: Lisa
authors.initials: L
authors.lastname: Mosconi
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Ricardo
authors.initials: R
authors.lastname: Osorio
authors.forename: Schantel
authors.initials: S
authors.lastname: Williams
authors.forename: Catherine
authors.initials: C
authors.lastname: Randall
authors.forename: Nicole
authors.initials: N
authors.lastname: Spector
authors.forename: Pauline
authors.initials: P
authors.lastname: McHugh
authors.forename: John
authors.initials: J
authors.lastname: Murray
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pirraglia
authors.forename: Shankar
authors.initials: S
authors.lastname: Vallabhajolusa
authors.forename: Mony
authors.initials: M
authors.lastname: de Leon
mesh_terms: D000368:Aged; D000814:Aniline Compounds / Q000493:pharmacokinetics; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D013844:Thiazoles / Q000493:pharmacokinetics; D066127:White Matter / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D019275:Radiopharmaceuticals; D013844:Thiazoles