title: Mechanism and regulation of meiotic recombination initiation.
abstract: Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence.
authors.affiliation: Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065 Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
authors.forename: Isabel
authors.initials: I
authors.lastname: Lam
authors.affiliation: Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065 Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065 Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
authors.forename: Scott
authors.initials: S
authors.lastname: Keeney
mesh_terms: D000818:Animals; D005075:Biological Evolution; D018797:Cell Cycle Proteins / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000502:physiology*; D004706:Endodeoxyribonucleases / Q000378:metabolism*; D006801:Humans; D008540:Meiosis / Q000502:physiology*; D060066:Protein Interaction Maps; D011995:Recombination, Genetic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013045:Species Specificity; D000099257:Meiotic Recombination Protein SPO11
chemical_list: D018797:Cell Cycle Proteins; D004706:Endodeoxyribonucleases; D000099257:Meiotic Recombination Protein SPO11