title: Binocular form deprivation influences the visual cortex.
abstract: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors are considered to play a crucial role in synaptic plasticity in the developing visual cortex. In this study, we established a rat model of binocular form deprivation by suturing the rat binocular eyelids before eye-opening at postnatal day 14. During development, the decay time of excitatory postsynaptic currents mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors of normal rats became longer after eye-opening; however, the decay time did not change significantly in binocular form deprivation rats. The peak value in the normal group became gradually larger with age, but there was no significant change in the binocular form deprivation group. These findings indicate that binocular form deprivation influences the properties of excitatory postsynaptic currents mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors in the rat visual cortex around the end of the critical period, indicating that form stimulation is associated with the experience-dependent modification of neuronal synapses in the visual cortex.
authors.affiliation: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University of Chinese PLA, Chongqing 400038, China.
authors.forename: Mingming
authors.initials: M
authors.lastname: Liu
authors.affiliation: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University of Chinese PLA, Chongqing 400038, China.
authors.forename: Chuanhuang
authors.initials: C
authors.lastname: Weng
authors.affiliation: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University of Chinese PLA, Chongqing 400038, China.
authors.forename: Hanping
authors.initials: H
authors.lastname: Xie
authors.affiliation: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University of Chinese PLA, Chongqing 400038, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
keywords: binocular form deprivation; excitatory postsynaptic currents; neural development; neural regeneration; regeneration; visual cortex; visual development; whole-cell recording; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors