title: Surface-adsorbed reverse micelle-loaded solid self-nanoemulsifying drug delivery system of talinolol.
abstract: The aim of present investigation was to develop surface-adsorbed reverse-micelle-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) of talinolol in order to enhance its in vitro dissolution rate, which in turn enhance the bioavailability. SNEDDS were prepared using aqueous phase titration method. Thermodynamically stable formulations were characterized in terms of droplet size, viscosity, % transmittance, drug content and surface morphology. Low cost acid-treated coffee husk was used as an effective biosorbent for preparation of solid SNEDDS. Developed SNEDDS were subjected to in vitro drug release/dissolution studies. In vitro drug release studies showed 99.6% release of talinolol from optimized solid SNEDDS TS3 after 120 min of study. The results of solubility studies showed 4849.5-folds enhancement in solubility of talinolol from optimized SNEDDS as compared to its aqueous solubility.
authors.affiliation: a Center of Excellence in Biotechnology Research, College of Science, King Saud University , Riyadh , Saudi Arabia .|b Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia , and.
authors.forename: Faiyaz
authors.initials: F
authors.lastname: Shakeel
authors.affiliation: a Center of Excellence in Biotechnology Research, College of Science, King Saud University , Riyadh , Saudi Arabia .|b Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia , and.
authors.forename: Nazrul
authors.initials: N
authors.lastname: Haq
authors.affiliation: b Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia , and.|c Kayyali Chair for Pharmaceutical Industry, College of Pharmacy, King Saud University , Riyadh , Saudi Arabia.
authors.forename: Fars K
authors.initials: FK
authors.lastname: Alanazi
authors.affiliation: a Center of Excellence in Biotechnology Research, College of Science, King Saud University , Riyadh , Saudi Arabia .|b Department of Pharmaceutics , College of Pharmacy, King Saud University , Riyadh , Saudi Arabia , and.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Alsarra
mesh_terms: D000327:Adsorption; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065546:Drug Liberation; D004655:Emulsions / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011412:Propanolamines / Q000737:chemistry*; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry; D014783:Viscosity
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D005079:Excipients; D008823:Micelles; D011412:Propanolamines; D013501:Surface-Active Agents; C011550:talinolol
keywords: Biosorption; Talinolol; coffee husk; dissolution; self-nanoemulsifying drug delivery system