title: Dynamic changes and clinical significance of serum tryptase levels in STEMI patients treated with primary PCI.
abstract: OBJECTIVE
  To investigate the dynamic changes in serum tryptase levels and their association with clinical data in patients with acute ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).
  
  
  METHODS
  Serum tryptase levels were measured in 99 STEMI patients and 25 control subjects.
  
  
  RESULTS
  Tryptase levels were significantly increased at admission, and descended after primary PCI. Tryptase levels at 0.5, 2 and 6 h after PCI were negatively correlated with the percentage of ST-segment resolution (STR) as well as left ventricular ejection fraction (LVEF).
  
  
  CONCLUSIONS
  High tryptase levels after PCI were associated with poor myocardial reperfusion and poor cardiac function.
authors.affiliation: Department of Cardiology, Key Laboratory of Cardiovascular Molecular Biology and Regulatory peptides, Ministry of Health, Peking University Third Hospital , Beijing , China.
authors.forename: Shaomin
authors.initials: S
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Mu
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.forename: Chuan
authors.initials: C
authors.lastname: Ren
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
authors.forename: Lijun
authors.initials: L
authors.lastname: Guo
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000503:physiopathology / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D020127:Recovery of Function; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D053802:Tryptases / Q000097:blood*; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D053802:Tryptases
keywords: Acute myocardial infarction; ST-segment resolution; mast cell; tryptase