title: [Protective effects and mechanism of congguiyishen capsules on diabetic nephropathy rats].
abstract: OBJECTIVE
  To study the curative and protective effects of Congguiyishen Capsules on the diabetic nephropathy (DN) model rats.
  
  
  METHODS
  Established the DN model rats by intraperitoneal injection of urea bacteria element (Streptozotocin, STZ). The rats were divided into six groups including normal control group, model group, positive control group, high-dosage group, medium-dosage group and low-dosage group. After oral administration for 4 weeks, determined the 24 h urinary protein, Cr, kidney mass/body mass, FBG, Ang II, AT1R, AGTRAP and CTGF in the kidney. Observed the pathological damage of kidney tissue with Masson staining.
  
  
  RESULTS
  After treatment, Cr, kidney mass index, 24 h urine protein, FBG and Ang II were decreased signicantly (P < 0.05). And the treatment also alleviated the pathological damage of kidney tissue.
  
  
  CONCLUSIONS
  Congguiyishen Capsules have protective effect for DN model rats. The mechanism may be related to the suppression of inflammatory response and down-regulating the expression of AT1R, AGTRAP and CTGF.
authors.forename: Xian-Chun
authors.initials: XC
authors.lastname: Duan
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Fang
authors.forename: Yong-Zhong
authors.initials: YZ
authors.lastname: Wang
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Xian-Mei
authors.initials: XM
authors.lastname: Yao
authors.forename: Lun-Zhu
authors.initials: LZ
authors.lastname: Xia
mesh_terms: D000804:Angiotensin II / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011507:Proteinuria / Q000652:urine; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D000804:Angiotensin II; D013311:Streptozocin