title: Association between +936 C>T gene polymorphism of vascular endothelial growth factor and lung cancer: a meta-analysis.
abstract: BACKGROUND
  +936C>T polymorphism of vascular endothelial growth factor (VEGF) is one of the most investigated polymorphisms, it has been suggested that it plays a vital role in tumorigenesis. Intensive studies centering on the association between VEGF +936C>T polymorphism and lung cancer risk or lung cancer patients' overall survival were conducted in recent years, but with inconclusive and ambiguous results.
  
  
  OBJECTIVE
  We investigated whether VEGF +936C>T polymorphism influences lung cancer risk and lung cancer patients' overall survival (OS) using pooled odds ratios (ORs) and hazard ratios (HRs) with their corresponding 95% confidence intervals (CI) under different genetic models.
  
  
  RESULTS
  A total of 12 eligible studies were included. In the overall analysis, we didn't find any statistical evidence that +936C>T polymorphism was related to the risk of lung cancer in any genetic model. However, increased lung cancer risk was detected in adenocarcinoma subgroup (OR=1.532, 95%CI: 1.016-2.312, P=0.042). For an aggregate result of survival analysis, +936C>T polymorphism was linked to an unfavorable OS (HR=2.248, 95%CI: 1.257-4.017, P=0.006) under homozygous model (TT/CC).
authors.affiliation: Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Wanjia
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Tuya
authors.initials: T
authors.lastname: Bai
authors.affiliation: Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Lv
authors.affiliation: Department of Pharmacology of Pharmaceutical College, Inner Mongolia Medical University, Hohhot, China.
authors.forename: Fuhou
authors.initials: F
authors.lastname: Chang
mesh_terms: D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A
keywords: +936C&gt;T; VEGF; lung cancer; meta-analysis; polymorphism