title: Impact of a spatial repellent on malaria incidence in two villages in Sumba, Indonesia.
abstract: A randomized, double-blinded, placebo-controlled study was conducted to examine the effect of spatial repellent (SR) in households at risk of malaria in Indonesia. Following presumptive radical cure for malaria in 180 adult men representing sentinels of new infection in four clusters within two villages, all households were given either metofluthrin or placebo mosquito coils. Weekly blood smear screening and human-landing mosquito catches were done throughout the 6 months intervention. Malaria infections occurred in 61 subjects living in placebo households and 31 subjects living in SR coil households, suggesting a 52% protective effect of SR. Likewise, anopheles indoor human landing rates were 32% lower in homes receiving SR coils. Differences in the malaria attack rate between SR- and placebo-treated homes was significant when not accounting for the effects of clustering. When the analysis was adjusted for intra-cluster correlation, the differences between SR- and placebo-treated homes were not statistically significant. The findings provide evidence of SR public health benefit and support a larger trial statistically powered to detect those effects.
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom din@eijkman.go.id.
authors.forename: Din
authors.initials: D
authors.lastname: Syafruddin
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bangs
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Dian
authors.initials: D
authors.lastname: Sidik
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Elyazar
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Puji B S
authors.initials: PB
authors.lastname: Asih
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Krisin
authors.initials: K
authors.lastname: Chan
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Siti
authors.initials: S
authors.lastname: Nurleila
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Christian
authors.initials: C
authors.lastname: Nixon
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Joko
authors.initials: J
authors.lastname: Hendarto
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Isra
authors.initials: I
authors.lastname: Wahid
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Hasanuddin
authors.initials: H
authors.lastname: Ishak
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Claus
authors.initials: C
authors.lastname: Bøgh
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: John P
authors.initials: JP
authors.lastname: Grieco
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: Nicole L
authors.initials: NL
authors.lastname: Achee
authors.affiliation: Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Public Health and Malaria Control, International SOS, Kuala Kencana, Papua Indonesia; Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand; Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; The Sumba Foundation, Bali, Indonesia; Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana; Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Baird
mesh_terms: D015331:Cohort Studies; D004311:Double-Blind Method; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007302:Insect Repellents; D008288:Malaria / Q000453:epidemiology* / Q000517:prevention & control; D010919:Placebos
chemical_list: D007302:Insect Repellents; D010919:Placebos