title: Cellular and molecular mechanisms underlying the action of ginsenoside Rg1 against Alzheimer's disease.
abstract: Ginsenoside Rg1 inhibits oxidation, aging and cell apoptosis, and improves cognitive function. In this study, we pretreated rat brain tissue sections with ginsenoside Rg1, and established brain slice models of Alzheimer's disease induced by okadaic acid. The results revealed that ginsenoside Rg1 pretreatment suppressed the increase in phosphorylated Tau protein expression induced by incubation with okadaic acid, and reduced brain-derived neurotrophic factor expression. These results suggest that ginsenoside Rg1 upregulates brain-derived neurotrophic factor expression and inhibits Tau protein phosphorylation in brain slices from a rat model of Alzheimer's disease.
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Geriatrics, Second Affiliated Hospital, College of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Encephalopathy, Xi'an Electric Power Central Hospital, Xi'an 710032, Shaanxi Province, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Research Center of Rehabilitation Science and Technology, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, Shaanxi Province, China.
authors.forename: Qiankun
authors.initials: Q
authors.lastname: Quan
authors.affiliation: Department of Laboratory Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wang
keywords: Alzheimer’s disease; brain-derived neurotrophic factor; ginsenoside Rg1; neural regeneration; okadaic acid; phosphorylated Tau protein; traditional Chinese medicine