title: Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography.
abstract: OBJECTIVE
  The purpose of this study was to classify and detect intraretinal hemorrhage (IRH) in spectral domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Initially the presentation of IRH in BRVO-patients in SD-OCT was described by one reader comparing color-fundus (CF) and SD-OCT using dedicated software. Based on these established characteristics, the presence and the severity of IRH in SD-OCT and CF were assessed by two other masked readers and the inter-device and the inter-observer agreement were evaluated. Further the area of IRH was compared.
  
  
  RESULTS
  About 895 single B-scans of 24 eyes were analyzed. About 61% of SD-OCT scans and 46% of the CF-images were graded for the presence of IRH (concordance: 73%, inter-device agreement: k = 0.5). However, subdivided into previously established severity levels of dense (CF: 21.3% versus SD-OCT: 34.7%, k = 0.2), flame-like (CF: 15.5% versus SD-OCT: 45.5%, k = 0.3), and dot-like (CF: 32% versus SD-OCT: 24.4%, k = 0.2) IRH, the inter-device agreement was weak. The inter-observer agreement was strong with k = 0.9 for SD-OCT and k = 0.8 for CF. The mean area of IRH detected on SD-OCT was significantly greater than on CF (SD-OCT: 11.5 ± 4.3 mm(2) versus CF: 8.1 ± 5.5 mm(2), p = 0.008).
  
  
  CONCLUSIONS
  IRH seems to be detectable on SD-OCT; however, the previously established severity grading agreed weakly with that assessed by CF.
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Marion R
authors.initials: MR
authors.lastname: Munk
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Roman
authors.initials: R
authors.lastname: Dunavoelgyi
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Baratsits
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Gerlinde
authors.initials: G
authors.lastname: Matt
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.|b Vienna Reading Center, Medical University Vienna , Vienna , Austria.
authors.forename: Alessio
authors.initials: A
authors.lastname: Montuoro
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Wolf
authors.initials: W
authors.lastname: Buehl
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Ursula
authors.initials: U
authors.lastname: Schmidt-Erfurth
authors.affiliation: a Department of Ophthalmology , Medical University of Vienna , Vienna , Austria and.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D015588:Observer Variation; D012166:Retinal Hemorrhage / Q000145:classification* / Q000175:diagnosis*; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity
keywords: Imaging; intraretinal blood; intraretinal hemorrhage; multimodal imaging; optical coherence tomography; retinal vein occlusion