title: [Establishment of spectrum-effect relationship network model of qizhiweitong granules promoting gastrointestinal motility].
abstract: OBJECTIVE
  To establish the spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointestinal motility for providing scientific basis for its quality control and efficacy evaluation.
  
  
  METHODS
  The Latin hypercube sampling was used to establish full-time multi-wavelength fusion fingerprints of different compatibility groups of Qizhiweitong granules. At the same time, the appreciation rate, the contents of cGMP and NO in small intestine smooth muscle cells after administrated drugs were determined. Then the spectrum-effect relationship of different compatibility groups were correlated, and the network model was established with gray correlation method and BP neural network.
  
  
  RESULTS
  20 compounds with correlation index more than 0.9 were found from 36 constituents in Qizhiweitong granules. The spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointestinal motility was successfully established. And through this model to forecast the result of the test, the absolute value of the relative error was less than 6.83%.
  
  
  CONCLUSIONS
  In this study, a spectrum-effect relationship network model of Qizhiweitong granules promoting gastrointestinal motility is established successfully, which provides a new method for its reasonable quality control and efficacy evaluation, lays the experiment basis for component-effect study, and provides reference for other TCM's study.
authors.forename: Yong-Rui
authors.initials: YR
authors.lastname: Bao
authors.forename: Shuai
authors.initials: S
authors.lastname: Wang
authors.forename: Xian-Sheng
authors.initials: XS
authors.lastname: Meng
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Yang
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Cui
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects; D008962:Models, Theoretical; D016571:Neural Networks, Computer; D010946:Plants, Medicinal / Q000737:chemistry; D011786:Quality Control; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal