title: Gluten sensitivity and relationship to psychiatric symptoms in people with schizophrenia.
abstract: The relationship between gluten sensitivity and schizophrenia has been of increasing interest and novel mechanisms explaining this relationship continue to be described. Our study in 100 people with schizophrenia compared to 100 matched controls replicates a higher prevalence of gluten sensitivity and higher mean antigliadin IgG antibody levels schizophrenia (2.9 ± 7.7 vs. 1.3 ± 1.3, p = 0.046, controlled for age). Additionally, we examined symptoms within the schizophrenia group and found that while positive symptoms are significantly lower in people who have elevated antigliadin antibodies (AGA; 4.11 ± 1.36 vs. 6.39 ± 2.99, p = 0.020), no robust clinical profile differentiates between positive and negative antibody groups. Thus, identifying people in schizophrenia who may benefit from a gluten-free diet remains possible by blood test only.
authors.affiliation: Temple University School of Medicine, 3500 North Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Jessica
authors.initials: J
authors.lastname: Jackson
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Baltimore, MD 21205, USA.
authors.forename: William
authors.initials: W
authors.lastname: Eaton
authors.affiliation: Neuropsychiatry Program Sheppard Pratt Hospital, 6501 North Charles Street, Baltimore, MD 21285, USA.
authors.forename: Nicola
authors.initials: N
authors.lastname: Cascella
authors.affiliation: Massachusetts General Hospital for Children, 175 Cambridge Street, Boston, MA 02114, USA; Massachusetts General Hospital East, 16th Street, Charlestown, MA 02129, USA.
authors.forename: Alessio
authors.initials: A
authors.lastname: Fasano
authors.affiliation: University of Maryland School of Medicine, 660 West Redwood Street, Baltimore, MD 21201, USA.
authors.forename: Debby
authors.initials: D
authors.lastname: Santora
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA.
authors.forename: Kelli
authors.initials: K
authors.lastname: Sullivan
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Feldman
authors.affiliation: National Institute on Drug Abuse, 251 Bayview Blvd., Baltimore, MD 21223, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Raley
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA.
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA.
authors.forename: William T
authors.initials: WT
authors.lastname: Carpenter
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA.
authors.forename: Haley
authors.initials: H
authors.lastname: Demyanovich
authors.affiliation: University of Maryland School of Medicine, Department of Psychiatry, Maryland Psychiatric Research Center, 55 Wade Avenue, Catonsville, MD 21228, USA. Electronic address: dkelly@mprc.umaryland.edu.
authors.forename: Deanna L
authors.initials: DL
authors.lastname: Kelly
mesh_terms: D000328:Adult; D015897:Comorbidity; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology*; D008297:Male; D011618:Psychotic Disorders / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology; D012559:Schizophrenia / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology
chemical_list: D005903:Gliadin
keywords: Celiac disease; Gliadin; Gluten; Gluten sensitivity; Schizophrenia