title: A free-radical cascade methylation/cyclization of N-arylacrylamides and isocyanides with dicumyl peroxide.
abstract: A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou, Gansu 730000, P. R. China.
authors.forename: Zhengbao
authors.initials: Z
authors.lastname: Xu
authors.forename: Chaoxian
authors.initials: C
authors.lastname: Yan
authors.forename: Zhong-Quan
authors.initials: ZQ
authors.lastname: Liu
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D010617:Phenanthridines / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D001593:Benzyl Compounds; D003486:Cyanides; D005609:Free Radicals; D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D007211:Indoles; D010617:Phenanthridines; C037517:dicumyl peroxide