title: Cerebral perfusion in insulin resistance and type 2 diabetes.
abstract: Cerebral perfusion was evaluated in 87 subjects prospectively enrolled in three study groups-healthy controls (HC), patients with insulin resistance (IR) but not with diabetes, and type 2 diabetes mellitus (T2DM). Participants received a comprehensive 8-hour clinical evaluation and arterial spin labeling magnetic resonance imaging (MRI). In order of decreasing significance, an association was found between cerebral blood flow (CBF) and sex, waist circumference, diastolic blood pressure (BP), end tidal CO2, and verbal fluency score (R(2)=0.27, F=5.89, P<0.001). Mean gray-matter CBF in IR was 4.4 mL/100 g per minute lower than in control subjects (P=0.005), with no hypoperfusion in T2DM (P=0.312). Subjects with IR also showed no CO2 relationship (slope=-0.012) in the normocapnic range, in contrast to a strong relationship in healthy brains (slope=0.800) and intermediate response (slope=0.445) in diabetic patients. Since the majority of T2DM but few IR subjects were aggressively treated with blood glucose, cholesterol, and BP lowering medications, our finding could be attributed to the beneficial effect of these drugs.
authors.affiliation: Department of Radiology, NYU School of Medicine, New York, New York, USA.
authors.forename: Henry
authors.initials: H
authors.lastname: Rusinek
authors.affiliation: Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Ha
authors.affiliation: Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
authors.forename: Po Lai
authors.initials: PL
authors.lastname: Yau
authors.affiliation: Department of Radiology, NYU School of Medicine, New York, New York, USA.
authors.forename: Pippa
authors.initials: P
authors.lastname: Storey
authors.affiliation: Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
authors.forename: Aziz
authors.initials: A
authors.lastname: Tirsi
authors.affiliation: Department of Psychiatry, NYU School of Medicine, New York, New York, USA.
authors.forename: Wai Hon
authors.initials: WH
authors.lastname: Tsui
authors.affiliation: NYU School of Medicine, New York, New York, USA.
authors.forename: Olivia
authors.initials: O
authors.lastname: Frosch
authors.affiliation: NYU School of Medicine, New York, New York, USA.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Azova
authors.affiliation: 1] Department of Psychiatry, NYU School of Medicine, New York, New York, USA [2] Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
authors.forename: Antonio
authors.initials: A
authors.lastname: Convit
mesh_terms: D000704:Analysis of Variance; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies