title: Amyloid imaging with [(18)F]florbetapir in geriatric depression: early-onset versus late-onset.
abstract: BACKGROUND
  We examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta-amyloid (Aβ) pathology on the pathology of GD by using [(18)F]florbetapir PET.
  
  
  METHODS
  Thirty-three elderly patients (76.7 ± 4.2 years) and 22 healthy controls (HC; 72.0 ± 4.5 years, average ± SD) were examined by [(18)F]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini-Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut-off value of 1.08 for SUVR was defined as Aβ-positive.
  
  
  RESULTS
  Of the patients and HC, 39.4% and 27.3%, respectively, were beta-amyloid-positive. The onset age of GD was significantly correlated with SUVR (r = 0.44, p < 0.01). Compared to patients without Aβ (GD-Aβ), patients with Aβ (GD + Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD + Aβ had significantly older average ± SD age at onset of GD (73.6 ± 7.1 versus 58.7 ± 17.8, p < 0.01) and significantly shorter average ± SD time between onset of GD and PET scan day (3.1 ± 5.2 years versus 18.1 ± 18.6 years, p < 0.001) than GD-Aβ.
  
  
  CONCLUSIONS
  Our results showed that the rate of Aβ positivity was higher in late-onset GD and that onset-age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset.
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Amane
authors.initials: A
authors.lastname: Tateno
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakayori
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
authors.affiliation: Clinical Imaging Center for Healthcare, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ishihara
authors.affiliation: Department of Radiology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
authors.affiliation: Department of Pharmacology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Suzuki
authors.affiliation: Department of Neuropsychiatry, Nippon Medical School, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000814:Aniline Compounds / Q000378:metabolism*; D016022:Case-Control Studies; D060825:Cognitive Dysfunction / Q000175:diagnosis; D003866:Depressive Disorder / Q000000981:diagnostic imaging* / Q000473:pathology / Q000523:psychology; D005026:Ethylene Glycols / Q000378:metabolism*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D011569:Psychiatric Status Rating Scales
chemical_list: D000814:Aniline Compounds; D005026:Ethylene Glycols; C545186:florbetapir
keywords: Alzheimer's disease; beta-amyloid; geriatric depression; positron emission tomography