title: Uterine cytokine profile in a rat model of endometritis.
abstract: OBJECTIVE
  Endometritis is a common reproductive disorder in female domestic animals. Roles of cytokines and chemokines have been implicated in this disease. To date, no comprehensive panel of the cytokine profile in inflammatory sites of endometritis has been reported.
  
  
  METHODS
  To address cytokine profiles in endometritis, a bacteria-induced rat model of endometritis was developed and levels of 27 cytokines were measured in paired uterine horn tissues using a multiple cytokine array.
  
  
  RESULTS
  Of the 27 cytokines, five pro-inflammatory mediators, including three cytokine-induced neutrophil chemo-attractant (CINC)-1, CINC-2 and CINC-3, interleukin (IL)-1a and CXC family member CXCL5/LIX were increased upon the stimulation of bacteria.
  
  
  CONCLUSIONS
  High expression of CINCs as well IL-1a and CXCL5/LIX suggests their potent roles in the pathogenicity of endometritis.
authors.affiliation: College of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
authors.forename: Daojun
authors.initials: D
authors.lastname: Xu
authors.forename: Hailin
authors.initials: H
authors.lastname: Xiong
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Xiao
authors.forename: Jun
authors.initials: J
authors.lastname: He
authors.forename: Qing
authors.initials: Q
authors.lastname: Liao
authors.forename: Liqun
authors.initials: L
authors.lastname: Xue
authors.forename: Naidong
authors.initials: N
authors.lastname: Wang
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D016207:Cytokines / Q000032:analysis*; D004195:Disease Models, Animal; D004716:Endometritis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D004927:Escherichia coli Infections / Q000378:metabolism*; D005260:Female; D018836:Inflammation Mediators / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000378:metabolism*; D014599:Uterus / Q000737:chemistry* / Q000382:microbiology / Q000473:pathology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D019342:Acetic Acid
keywords: Cytokine profile; endometritis; rat