title: [Pharmacokinetics of three peroral dosage forms of new dipeptide anxiolytic drug GB-115].
abstract: Comparative analysis of the pharmacokinetics and bioequivalence of a new dipeptide anxiolytic compound GB-115 in three drug forms for peroral administration, developed in the experimental technology department of the Institute of pharmacology RAMS, was carried out. Three drug forms of GB-115 and a micronized substance of this compound were different in composition and technology of production. As a result of the investigations of GB-115 pharmacokinetics, drug form No. 2 (with a relative bioequivalence of 192%) showed advantages in comparison to the micronized parent substance and two other drug forms (bioequivalence, 53 and 117%) and can be recommended for further pharmacological studies.
authors.forename: E V
authors.initials: EV
authors.lastname: Ivannikova
authors.forename: S S
authors.initials: SS
authors.lastname: Boĭko
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: S Iu
authors.initials: SIu
authors.lastname: Raskin
authors.forename: E V
authors.initials: EV
authors.lastname: Blynskaia
authors.forename: K G
authors.initials: KG
authors.lastname: Turchinskaia
authors.forename: A A
authors.initials: AA
authors.lastname: Illarionov
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001682:Biological Availability; D004151:Dipeptides / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D004151:Dipeptides; C520797:GB-115