title: Synthesis and biomedical applications of xylosides.
abstract: Xylosides modulate the biosynthesis of sulfated glycosaminoglycans (GAGs) in various cell types. A new class of xylosides called "click-xylosides" has been synthesized for their biostability, ease of chemical synthesis, and tunable sulfated GAG biogenesis in vitro and in vivo. These click-xylosides have several therapeutic and biomedical applications in the regulation of angiogenesis, tumor inhibition, and regeneration. This protocol focuses on the synthesis of click-xylosides, their cellular priming activities, and biomedical applications.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, 84112, USA.
authors.forename: Mausam
authors.initials: M
authors.lastname: Kalita
authors.forename: Maritza V
authors.initials: MV
authors.lastname: Quintero
authors.forename: Karthik
authors.initials: K
authors.lastname: Raman
authors.forename: Vy M
authors.initials: VM
authors.lastname: Tran
authors.forename: Balagurunathan
authors.initials: B
authors.lastname: Kuberan
mesh_terms: D000107:Acetylation; D000818:Animals; D020811:Biomedical Technology / Q000379:methods*; D016466:CHO Cells; D002417:Cattle; D057930:Click Chemistry; D006224:Cricetinae; D003412:Cricetulus; D006025:Glycosaminoglycans / Q000737:chemistry / Q000378:metabolism; D006027:Glycosides / Q000096:biosynthesis* / Q000737:chemistry; D018919:Neovascularization, Physiologic
chemical_list: D006025:Glycosaminoglycans; D006027:Glycosides; C010807:xylosides