title: Flavonoids of Rosa roxburghii Tratt act as radioprotectors.
abstract: BACKGROUND
  To study the radioprotective effects of flavonoids from Rosa roxburghii Tratt (FRT).
  
  
  METHODS
  The radioprotective effects of FRT were investigated by examining cell viability, 30-day survival of mice and the number of colony-forming units in spleen (CFU-S) after total-body 60Co irradiation.
  
  
  RESULTS
  The survival rates of irradiated cells gradually increased with increasing concentrations of FRT. The survival rate was the highest at 87% with a concentration of 30 μg/mL. Pretreatment with FRT was needed to realize its radioprotective activity in mice at the dose of 60 mg/kg. With the increasing doses of 30 mg/kg, 60 mg/kg and 120 mg/kg, the numbers of CFU-S increased, and were significantly different compared with the control group.
  
  
  CONCLUSIONS
  Pretreatment with FRT prior to irradiation resulted in significantly higher cell survival at 24 h after 5 Gy radiation, increased 30-day survival in mice after exposure to a potentially lethal dose of 8 Gy, and resulted in a higher number of CFU-S in mice after exposure to a dose of 6 Gy. These results collectively indicate that FRT is an effective radioprotective agent.
authors.affiliation: Department of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, China E-mail : 13273730271@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
authors.forename: Wen-Bo
authors.initials: WB
authors.lastname: Zhang
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Cai
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Lu
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: He
authors.forename: Pei-Yong
authors.initials: PY
authors.lastname: Qiu
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
mesh_terms: D000818:Animals; D003114:Colony-Forming Units Assay; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D005720:Gamma Rays; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D027826:Rosa / Q000737:chemistry*; D013154:Spleen / Q000187:drug effects* / Q000528:radiation effects; D015996:Survival Rate; D014916:Whole-Body Irradiation
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; D011837:Radiation-Protective Agents