title: Plasmonic caged gold nanorods for near-infrared light controlled drug delivery.
abstract: A new near-infrared light-controlled drug delivery system based on caged gold nanorods (CGNRs) is demonstrated. The loading and release process of drug payloads into/from CGNR nanocarriers were systematically investigated. The drug-loaded CGNR constructs could enable combined chemotherapy and photo-thermal effects in killing tumor cells upon light irradiation, therefore, enhance the killing efficiency. In conjunction with visibility under quenching-free dark-field imaging, CGNRs may serve as multifunctional theranostic reagents towards cancer diagnostics and therapeutics.
authors.affiliation: Department of Chemical Engineering, Monash University, Clayton 3800, Victoria, Australia. wenlong.cheng@monash.edu.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Romiza
authors.initials: R
authors.lastname: Mazid
authors.forename: Lim Wei
authors.initials: LW
authors.lastname: Yap
authors.forename: Xinyong
authors.initials: X
authors.lastname: Li
authors.forename: Wenlong
authors.initials: W
authors.lastname: Cheng
mesh_terms: D016503:Drug Delivery Systems; D006046:Gold / Q000737:chemistry / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D043942:Nanotubes / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D010789:Phototherapy / Q000379:methods*
chemical_list: D006046:Gold