title: Adipocyte-derived players in hematologic tumors: useful novel targets?
abstract: BACKGROUND
  Adipocytes and their products play essential roles in tumor establishment and progression. As the main cellular component of the bone marrow, adipocytes may contribute to the development of hematologic tumors.
  
  
  METHODS
  This review summarizes experimental data on adipocytes and their interaction with various cancer cells. Special focus is set on the interactions of bone marrow adipocytes and normal and transformed cells of the hematopoietic system such as myeloma and leukemia cells. Current in vitro and in vivo data are summarized and the potential of novel therapeutic targets is critically discussed.
  
  
  CONCLUSIONS
  Targeting lipid metabolism of cancer cells and adipocytes in combination with standard therapeutics might open novel therapeutic avenues in these cancer entities. Adipocyte-derived products such as free fatty acids and specific adipokines such as adiponectin may be vital anti-cancer targets in hematologic malignancies. However, available data on lipid metabolism is currently mostly referring to peripheral fat cell/cancer cell interactions and results need to be evaluated specifically for the bone marrow niche.
authors.affiliation: Tyrolean Cancer Research Institute , Innrain 66, 6020 Innsbruck , Austria karin.joehrer@tkfi.at.
authors.forename: Karin
authors.initials: K
authors.lastname: Jöhrer
authors.forename: Christian
authors.initials: C
authors.lastname: Ploner
authors.forename: Shanmugapriya
authors.initials: S
authors.lastname: Thangavadivel
authors.forename: Philipp
authors.initials: P
authors.lastname: Wuggenig
authors.forename: Richard
authors.initials: R
authors.lastname: Greil
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D054392:Adipokines / Q000378:metabolism / Q000502:physiology*; D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D002450:Cell Communication; D019337:Hematologic Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D008055:Lipids / Q000502:physiology*; D058990:Molecular Targeted Therapy / Q000379:methods
chemical_list: D054392:Adipokines; D008055:Lipids
keywords: adipocyte; adipokine; bone marrow; chemokine; leukemia; myeloma