title: Gamma knife treatment for refractory epilepsy in seizure focus localized by positron emission tomography/CT.
abstract: A total of 80 patients with refractory epilepsy were recruited from the Inner Mongolia Medical College Affiliated Hospital. The foci of 60% of the patients could be positioned using a combined positron emission tomography/CT imaging modality. Hyper- and hypometabolism foci were examined as part of this study. Patients who had abnormal metabolism in positron emission tomography/CT imaging were divided into intermittent-phase group and the seizure-phase group. The intermittent-phase group was further divided into a single-focus group and a multiple-foci group according to the number of seizure foci detected by imaging. Following gamma knife treatment, seizure frequency was significantly lower in the intermittent-phase group and the seizure-phase group. Wieser's classification reached Grade I or II in nearly 40% of patients. Seizure frequency was significantly lower following treatment, but Wieser's classification score was significantly higher in the seizure-phase group compared with the intermittent-phase group. Seizure frequency was significantly lower following treatment in the single-focus group, but Wieser's classification score was significantly higher in the single-focus group as compared with the multiple-foci group.
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Bai
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Xuemei
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Gamma Knife Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Neurology, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Shigang
authors.initials: S
authors.lastname: Zhao
authors.affiliation: Department of MRI Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Han
authors.affiliation: Department of Emergency Medical Center, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Linjun
authors.initials: L
authors.lastname: Hao
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050, Inner Mongolia Autonomous Region, China.
authors.forename: Xiangcheng
authors.initials: X
authors.lastname: Wang
keywords: 18F-fluorodeoxyglucose; epilepsy; gamma knife radiosurgery; metabolism; neural regeneration; positron emission tomography/CT; seizure