title: Association of Helicobacter pylori and iNOS production by macrophages and lymphocytes in the gastric mucosa in chronic gastritis.
abstract: Helicobacter pylori is one of the most common causes of chronic gastritis. With the development of the disease cellular inflammatory infiltrates composed of lymphocytes, plasma cells, and macrophages are formed in epithelium and lamina propria of the stomach. These cells are capable of secreting a number of active substances, including inducible nitric oxide synthase (iNOS). We examined the relationship between H. pylori and secretion of iNOS by cells of inflammatory infiltrates in chronic gastritis by light microscopy and immunohistochemistry. The data obtained indicate that stimulation of H. pylori immune system cells of the host organism during development of chronic gastritis causes increase in number of macrophages and lymphocytes in the inflammatory infiltrate of the gastric mucosa. This is accompanied with increased expression of inducible NO-synthase with excess free radicals in the tissues, which leads to secondary alterations and exacerbates the inflammation with impaired regeneration processes.
authors.affiliation: FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
authors.forename: Lilia A
authors.initials: LA
authors.lastname: Cherdantseva
authors.affiliation: FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
authors.forename: Oksana V
authors.initials: OV
authors.lastname: Potapova
authors.affiliation: FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
authors.forename: Tatyana V
authors.initials: TV
authors.lastname: Sharkova
authors.affiliation: FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
authors.forename: Yana Yu
authors.identifier: 0000-0002-6544-5778
authors.initials: YY
authors.lastname: Belyaeva
authors.affiliation: FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, Russia.
authors.forename: Vyacheslav A
authors.identifier: 0000-0002-5078-4216
authors.initials: VA
authors.lastname: Shkurupiy
mesh_terms: D002452:Cell Count; D002908:Chronic Disease; D005753:Gastric Mucosa / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D005756:Gastritis / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology* / Q000502:physiology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D008264:Macrophages / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D008875:Middle Aged; D052247:Nitric Oxide Synthase Type II / Q000276:immunology* / Q000378:metabolism
chemical_list: D052247:Nitric Oxide Synthase Type II