title: Placebo-driven clinical trials of yeast-derived β-(1-3) glucan in children with chronic respiratory problems.
abstract: BACKGROUND
  The role of glucan in stimulation of immune reactions has been studied for several decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems.
  
  
  METHODS
  We measured the levels of albumin, lysozyme and CRP in saliva of 40 children aged 8-12 years and evaluate the effects of 100 mg/d oral dose of glucan.
  
  
  RESULTS
  We found a significant increase in production of changes in production of lysozyme and CRP in glucan-treated children. In addition, a strong improvement in general conditions was found.
  
  
  CONCLUSIONS
  Short-term oral application of natural immunomodulator β-glucan stimulated mucosal immunity of children with chronic respiratory problems.
authors.affiliation: 1 University of Louisville, Department of Pathology, Louisville, KY, USA ; 2 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 3 Sanatorium EDEL, Zlaté Hory, Czech Republic.
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vetvicka
authors.affiliation: 1 University of Louisville, Department of Pathology, Louisville, KY, USA ; 2 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 3 Sanatorium EDEL, Zlaté Hory, Czech Republic.
authors.forename: Josef
authors.initials: J
authors.lastname: Richter
authors.affiliation: 1 University of Louisville, Department of Pathology, Louisville, KY, USA ; 2 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 3 Sanatorium EDEL, Zlaté Hory, Czech Republic.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Svozil
authors.affiliation: 1 University of Louisville, Department of Pathology, Louisville, KY, USA ; 2 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 3 Sanatorium EDEL, Zlaté Hory, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Rajnohová Dobiášová
authors.affiliation: 1 University of Louisville, Department of Pathology, Louisville, KY, USA ; 2 Zdravotní ústav se sídlem v Ústí nad Labem, Czech Republic ; 3 Sanatorium EDEL, Zlaté Hory, Czech Republic.
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Král
keywords: Glucan; children; lysozyme; mucosal immunity; saliva