title: Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis.
abstract: BACKGROUND
  A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results.
  
  
  METHODS
  We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility.
  
  
  RESULTS
  A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results.
  
  
  CONCLUSIONS
  Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.
authors.affiliation: Department of Clinical Laboratory, Hubei Maternal and Child Health Hospital, Wuhan, China E-mail : chenwei.chenjingyi@gmail.com; doremi1985@sina.com.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hong
authors.forename: Xue-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Jiao-Yuan
authors.initials: JY
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Liu
authors.forename: Na
authors.initials: N
authors.lastname: Shen
authors.forename: Bei-Bei
authors.initials: BB
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Gong
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D016366:Open Reading Frames / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors