title: Integration of nanoassembly functions for an effective delivery cascade for cancer drugs.
abstract: A "cluster-bomb"-like lipid-dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like "bomblets", enabling tumor penetration, cell internalization, and drug release.
authors.affiliation: Center for Bionanoengineering and Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, China, 310027; Department of Chemical Engineering, University of Wyoming, Laramie, WY, USA, 82071.
authors.forename: Qihang
authors.initials: Q
authors.lastname: Sun
authors.forename: Xuanrong
authors.initials: X
authors.lastname: Sun
authors.forename: Xinpeng
authors.initials: X
authors.lastname: Ma
authors.forename: Zhuxian
authors.initials: Z
authors.lastname: Zhou
authors.forename: Erlei
authors.initials: E
authors.lastname: Jin
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Youqing
authors.initials: Y
authors.lastname: Shen
authors.forename: Edward A
authors.initials: EA
authors.lastname: Van Kirk
authors.forename: William J
authors.initials: WJ
authors.lastname: Murdoch
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Lott
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Lodge
authors.forename: Maciej
authors.initials: M
authors.lastname: Radosz
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000737:chemistry; D050091:Dendrimers; D004317:Doxorubicin / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D050091:Dendrimers; D008823:Micelles; D010714:Phosphatidylethanolamines; C038089:1,2-distearoylphosphatidylethanolamine; C094877:dioleoyl phosphatidylethanolamine; D011092:Polyethylene Glycols; D004317:Doxorubicin; D002784:Cholesterol
keywords: biomedical applications; dendrimers; drug delivery; lipids; nanomedicine; self-assembly