title: Gene polymorphism of rs556621 but Not rs11984041 is associated with the risk of large artery atherosclerotic stroke in a Xinjiang Uyghur population.
abstract: BACKGROUND
  Stroke is one of the main causes of death and adult chronic disability. Recently, 2 independent genome-wide association studies reported that the genetic variants (rs556621 and rs11984041) are significantly associated with large artery atherosclerosis (LAA).
  
  
  METHODS
  To determine whether these 2 variants are associated with the pathogenesis of LAA in stroke patients from the Xinjiang Uyghur autonomous region of China, both variants were evaluated in a series of 733 LAA stroke patients (434 Han and 299 Uyghur) and 725 age-, gender-, smoking-, alcohol habits- and ethnicity-matched controls (401 Han and 324 Uyghur).
  
  
  RESULTS
  For rs556621, significant differences in genotypic and allelic distributions were observed between Uyghur patients and controls (P = .045 for genotypic distribution, P = .042 for allelic distribution) but not in the Chinese Han cohort (P > .05). No significant differences were found in genotypic and allele distributions between patients and controls for rs11984041 in either the Chinese Han or Uyghur cohort (P > .05).
  
  
  CONCLUSIONS
  The variant rs556621 but not rs11984041 may increase susceptibility of LAA stroke in the Xinjiang Uyghur population.
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China; Department of Neurology, the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhongyang
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ru
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Heng
authors.initials: H
authors.lastname: Yang
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Zheng
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ding
authors.initials: D
authors.lastname: Liu
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Deng
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, the Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China.
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China. Electronic address: docsong@126.com.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001158:Arteries / Q000473:pathology; D050197:Atherosclerosis / Q000150:complications*; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005006:Ethnicity; D005260:Female; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D014644:Genetic Variation; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020521:Stroke / Q000208:ethnology* / Q000235:genetics*
keywords: Stroke; genetic analysis; large artery atherosclerosis stroke; variants