title: Effects of functional endoscopic sinus surgery on chronic rhinosinusitis resistant to medication.
abstract: OBJECTIVE
  To evaluate the therapeutic effects of functional endoscopic sinus surgery in patients with chronic rhinosinusitis who were unresponsive to medical treatment.
  
  
  METHODS
  A total of 232 patients were divided into 2 groups: a functional endoscopic sinus surgery group (n = 162) and a conservative therapy group (n = 70). Efficacy was assessed in terms of Lund-Kennedy endoscopy scores and Sino-Nasal Outcome Test 20 symptom scores.
  
  
  RESULTS
  In the functional endoscopic sinus surgery group, Lund-Kennedy and Sino-Nasal Outcome Test 20 scores were significantly lower at 3, 6 and 12 months post-surgery compared with baseline scores. In the conservative therapy group, both sets of scores were significantly lower at 3 months, but not at 12 months. In this latter group, the Lund-Kennedy scores decreased only slightly and the Sino-Nasal Outcome Test 20 scores significantly decreased at six months compared with initial scores, indicating disparity between the subjective and objective measures. Patient-reported symptom improvement was better in the functional endoscopic sinus surgery group than in the medication group at 12 months (p < 0.001).
  
  
  CONCLUSIONS
  These findings suggest that functional endoscopic sinus surgery has better efficacy over a longer period compared with conservative therapy.
authors.affiliation: Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
authors.forename: Y
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
authors.forename: T
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology-Head Neck Surgery,Third Xiangya Hospital, Central South University,Changsha,China.
authors.forename: G
authors.initials: G
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004351:Drug Resistance; D024881:Drug Resistance, Bacterial; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012220:Rhinitis / Q000188:drug therapy / Q000601:surgery*; D012852:Sinusitis / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents