title: Condition-determined multicomponent reactions of 1,3-dicarbonyl compounds and formaldehyde.
abstract: By means of changing the reaction parameters, different products could be generated selectively starting from the same combination of substrates involving 1,3-dicarbonyl compounds and formaldehyde. This strategy enabled us to access diverse molecules without changing both starting material and reactor, maximizing thus the multifunctionality of the synthetic system. For example, starting from a 1,3-dicarbonyl compound, formaldehyde and 1,1-diphenylethylene, two kinds of products could be selectively formed including (i) a densely substituted dihydropyran and (ii) a C2-cinnamyl substituted 1,3-dicarbonyl compound. A one-pot three-component reaction of phenacylpyridinium salt, 1,3-dicarbonyl compound, and formaldehyde was also investigated, which produced either 2,4-diacyl-2,3-dihydrofuran or 2,4-diacyl-2-hydroxylmethyl-2,3-dihydrofuran in good to excellent yield.
authors.affiliation: Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology , 430074, Wuhan, China.
authors.forename: Changhui
authors.initials: C
authors.lastname: Liu
authors.forename: Meng
authors.initials: M
authors.lastname: Shen
authors.forename: Bingbing
authors.initials: B
authors.lastname: Lai
authors.forename: Amir
authors.initials: A
authors.lastname: Taheri
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Gu
mesh_terms: D020650:Combinatorial Chemistry Techniques; D005557:Formaldehyde / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry
chemical_list: D005663:Furans; D011714:Pyrans; D013343:Styrenes; C073812:2,3-dihydrofuran; D005557:Formaldehyde; C007518:1,1-diphenylethylene
keywords: combinatorial chemistry; condition-determined MCR; diversity-oriented synthesis; multicomponent reactions