title: Macroautophagy and the oncogene-induced senescence.
abstract: The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been elucidated yet. Here, we discuss up-to-date concepts of senescence-related macroautophagy and evaluate the current trend of this growing research field, which has relevance in future perspectives toward therapeutic options against cancer.
authors.affiliation: Institute of Biochemistry and Molecular Medicine, National Council for Scientific and Technological Research, Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Buenos Aires , Argentina.
authors.forename: Daniel
authors.initials: D
authors.lastname: Grasso
authors.affiliation: Institute of Biochemistry and Molecular Medicine, National Council for Scientific and Technological Research, Department of Pathophysiology, School of Pharmacy and Biochemistry, University of Buenos Aires , Buenos Aires , Argentina.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Vaccaro
keywords: autophagy; cancer; oncogene-induced senescence; senescence; tumor suppression mechanisms