title: Donor or recipient origin of posttransplant lymphoproliferative disorders following solid organ transplantation.
abstract: Previous studies of donor or recipient origin of posttransplant lymphoproliferative disorders (PTLDs) following solid organ transplantation (SOT) have either been small or with selected patient groups. We studied tumor origin in a population-based cohort of 93 patients with PTLD following SOT. Tumor origin of PTLD tissue was analyzed by fluorescence in situ hybridization of the sex chromosomes in cases of sex mismatch between donor and recipient (n = 41), or HLA genotyping in cases of identical sex but different HLA type (n = 52). Tumor origin of PTLD could be determined in 67 of the 93 cases. All 67 PTLDs were of recipient origin. They were found in recipients of kidney (n = 38), liver (n = 12), heart (n = 10) and lung (n = 7). The most common recipient-derived lymphomas were monomorphic B-cell PTLDs (n = 45), monomorphic T cell PTLDs (n = 9), indolent lymphomas (n = 6), and polymorphic PTLD (n = 4). Half of the recipient-derived PTLDs were Epstein-Barr virus-positive. Twelve of the recipient-derived PTLDs were located in the grafts: in four cases exclusively and in eight cases in combination with disseminated disease outside the graft. Tumor origin was indeterminable in 26 cases, probably due to low DNA quality. We conclude that the vast majority of PTLDs after SOT was of recipient origin.
authors.affiliation: Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Kinch
authors.forename: L
authors.initials: L
authors.lastname: Cavelier
authors.forename: M
authors.initials: M
authors.lastname: Bengtsson
authors.forename: E
authors.initials: E
authors.lastname: Baecklund
authors.forename: G
authors.initials: G
authors.lastname: Enblad
authors.forename: C
authors.initials: C
authors.lastname: Backlin
authors.forename: U
authors.initials: U
authors.lastname: Thunberg
authors.forename: C
authors.initials: C
authors.lastname: Sundström
authors.forename: K
authors.initials: K
authors.lastname: Pauksens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D016377:Organ Transplantation / Q000009:adverse effects*; D011183:Postoperative Complications; D011379:Prognosis; D012307:Risk Factors; D014019:Tissue Donors; D066027:Transplant Recipients; D055815:Young Adult
chemical_list: D006680:HLA Antigens
keywords: Cancer/malignancy/neoplasia: hematogenous/leukemia/lymphoma; hematology/oncology; posttransplant lymphoproliferative disorder (PTLD); translational research/science