title: Potential therapeutic role of antagomiR17 for the treatment of chronic lymphocytic leukemia.
abstract: Recently it was reported that microRNA from the miR-17 ~ 92 family may have a key role in chronic lymphocytic leukemia (CLL). Here, we designed specific oligonucleotides to target endogenous miR-17 (antagomiR17). In-vitro administration of antagomiR17 effectively reduced miR-17 expression and the proliferation of CLL-like MEC-1 cells. When injected in-vivo in tumor generated by the MEC-1 cells in SCID mice, antagomiR17 dramatically reduced tumor growth and significantly increase survival. Altogether, our results provide the rationale for the use of antagomiR17 as a novel potential therapeutic tool in CLL and in other lymphoproliferative disorders where miR-17 has a driver role in tumor progression.
authors.forename: Sara
authors.initials: S
authors.lastname: Dereani
authors.forename: Paolo
authors.initials: P
authors.lastname: Macor
authors.forename: Tiziana
authors.initials: T
authors.lastname: D'Agaro
authors.forename: Nelly
authors.initials: N
authors.lastname: Mezzaroba
authors.forename: Michele
authors.initials: M
authors.lastname: Dal-Bo
authors.forename: Sara
authors.initials: S
authors.lastname: Capolla
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.forename: Erika
authors.initials: E
authors.lastname: Tissino
authors.forename: Giovanni
authors.initials: G
authors.lastname: Del Poeta
authors.forename: Sonia
authors.initials: S
authors.lastname: Zorzet
authors.affiliation: Clinical and Experimental Onco-Hematology Unit, Centro di Riferimento Oncologico, I,R,C,C,S,, Via Franco Gallini 2, Aviano, PN, Italy. vgattei@cro.it.
authors.forename: Valter
authors.initials: V
authors.lastname: Gattei
authors.forename: Riccardo
authors.initials: R
authors.lastname: Bomben
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D051379:Mice; D016513:Mice, SCID; D035683:MicroRNAs / Q000037:antagonists & inhibitors*; D009843:Oligoribonucleotides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; C524941:MIRN17 microRNA, human; D035683:MicroRNAs; D009843:Oligoribonucleotides