title: Intracellular sensing of viral DNA by the innate immune system.
abstract: Recent years have seen a great advance in knowledge of how a host senses infection. Nucleic acids, as a common denominator to all pathogens, are at the centre of several of the sensing pathways, especially those involved with the recognition of viruses. In this review we discuss the current knowledge on how intracellular DNA is sensed by the mammalian host.
authors.affiliation: Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Floraniopolis, Brazil. Electronic address: daniel.mansur@ufsc.br.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Mansur
authors.affiliation: Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK. Electronic address: gls37@cam.ac.uk.
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Smith
authors.affiliation: Department of Pathology, Tennis Court Road, Cambridge, CB2 1QP, UK. Electronic address: bf234@cam.ac.uk.
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Ferguson
mesh_terms: D000818:Animals; D015551:Autoimmunity; D004279:DNA, Viral / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D057131:Immune Evasion; D007113:Immunity, Innate / Q000502:physiology*; D042541:Intracellular Space / Q000378:metabolism; D015398:Signal Transduction; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000378:metabolism* / Q000517:prevention & control; D014780:Viruses / Q000235:genetics / Q000276:immunology*
chemical_list: D004279:DNA, Viral; D014765:Viral Vaccines
keywords: Autoinflammation; DNA sensing; Immune evasion; Type one interferon; Vaccines; Virus recognition