title: Predictive model for the detection of pulmonary hypertension in dogs with myxomatous mitral valve disease.
abstract: Pulmonary hypertension (PH) often occurs due to a left heart disease, such as myxomatous mitral valve disease (MMVD), in dogs and is diagnosed using Doppler echocardiography and estimated pulmonary arterial pressure. Diagnosis of PH in dogs requires expertise in echocardiography: however, the examination for PH is difficult to perform in a clinical setting. Thus, simple and reliable methods are required for the diagnosis of PH in dogs. The purpose of this study was to develop models using multiple logistic regression analysis to detect PH due to left heart disease in dogs with MMVD without echocardiography. The medical records of dogs with MMVD were retrospectively reviewed, and 81 dogs were included in this study and classified into PH and non-PH groups. Bivariate analysis was performed to compare all parameters between the groups, and variables with P values of <0.25 in bivariate analysis were included in multiple logistic regression analysis to develop models for the detection of PH. In multiple logistic regression analysis, the model included a vertebral heart scale short axis of >5.2 v, and a length of sternal contact of >3.3 v was considered suitable for the detection of PH. The predictive accuracy of this model (85.9%) was judged statistically adequate, and therefore, this model may be useful to screen for PH due to left heart disease in dogs with MMVD without echocardiography.
authors.affiliation: Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino-shi, Tokyo 180-8602, Japan.
authors.forename: Shoma
authors.initials: S
authors.lastname: Mikawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Toda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tominaga
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takemura
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D005260:Female; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008297:Male; D008945:Mitral Valve Prolapse / Q000150:complications / Q000662:veterinary*; D008954:Models, Biological; D011237:Predictive Value of Tests