title: Spiritual well-being and its influence on fatigue in patients undergoing active cancer directed treatment: a correlational study.
abstract: BACKGROUND
  Spiritual well-being and fatigue are key parameters in assessing health related quality of life that determine treatment tolerance, treatment outcomes and reflect patient's coping ability in the illness-wellness disease trajectory.
  
  
  METHODS
  A total of 200 patients on active cancer treatment were enrolled to the study. Functional assessment of chronic illness therapy-spirituality (FACIT-Sp) and FACIT-Fatigue scales were used to assess spiritual well-being and fatigue scores during their cancer treatment. Data were analyzed using one-way analysis of variance and bivariate relationships determined using the Spearman Correlation analysis. Linear regression analysis was performed to determine predictors of fatigue score during treatment.
  
  
  RESULTS
  Mean spiritual well-being score was 20.96 out of 48 and scores were significantly higher in females compared with males (P = 0.03), lower with higher stage (P = 0.008) and lower in head and neck and gastrointestinal malignancies (P = 0.03) when compared with gynecological and breast malignancies. Fatigue was present in all the 200 patients studied and the mean fatigue score was 13.09. Higher fatigue scores were observed in patients with advanced stages of cancer (Stage IV) (F [3,199] = 5.67, P = 0.001). There was a significant inverse relationship between fatigue scores with spiritual well-being (P < 0.001). Spiritual well-being score emerged as a significant primary negative predictor (β = -0.23, P = 0.001) for fatigue scores followed by stage of disease (β =0.23, P = 0.001) and gender (β = -0.18, P = 0.01) as significant secondary predictors.
  
  
  CONCLUSIONS
  Fatigue during cancer directed treatment is influenced by spiritual wellbeing, disease stage and gender. Further studies should examine the mediating variables that influence fatigue.
authors.forename: Shirley
authors.initials: S
authors.lastname: Lewis
authors.affiliation: Department of Palliative Medicine, Tata Memorial Centre, Mumbai, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Salins
authors.forename: M Raghavendra
authors.initials: MR
authors.lastname: Rao
authors.forename: Amrit
authors.initials: A
authors.lastname: Kadam
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003131:Combined Modality Therapy; D005221:Fatigue / Q000453:epidemiology / Q000209:etiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D029181:Spirituality; D011795:Surveys and Questionnaires