title: Association between CRP gene polymorphisms and the risk of preeclampsia in Han Chinese women.
abstract: BACKGROUND
  As an inflammatory marker, C-reactive protein (CRP) has elevated expression in preeclampsia (PE), which is implicated in the pathogenesis of PE, but there has been a lack of information on the possible association between genetic variants of CRP and PE. In this study, we aimed to assess the genetic association between CRP polymorphisms and the risk of PE in Han Chinese Women.
  
  
  METHODS
  Five single-nucleotide polymorphisms of CRP, rs2794521 (T>C), rs3091244 (C>T>A), rs3093068 (C>G), rs876538 (C>T), and rs1205 (C>T) were genotyped using the Sequenom method in 181 PE patients and 203 controls.
  
  
  RESULTS
  The T allele frequency for rs2794521 was significantly higher in PE patients than in controls (odds ratios [OR]=4.091; 95% confidence interval [CI]: 1.533-10.917; p=0.002). The TT genotype of rs2794521 conferred a risk for PE (TT vs. TC+CC: OR=4.062; 95% CI: 1.499-11.008; p=0.003) and severe PE (TT vs. TC+CC: OR=9.577; 95% CI: 1.267-72.397; p=0.006). The other four polymorphic loci were not different between the groups. The CRP H2 haplotype (T-C-C-G-C) was associated with PE (OR=2.129; 95% CI: 1.47-3.085; p<0.001), whereas the H1 haplotype (C-C-C-G-C) offered protection (OR=0.23; 95% CI: 0.066-0.8; p=0.01).
  
  
  CONCLUSIONS
  The CRP variant rs2794521 shows a strong association with PE in Han Chinese women. Pregnant women with the TT genotype of rs2794521 have higher odds of having PE, which further supports a possible role for CRP in PE.
authors.affiliation: 1 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University , Shenyang, China .
authors.forename: Yuting
authors.initials: Y
authors.lastname: Wang
authors.forename: Qidi
authors.initials: Q
authors.lastname: Wang
authors.forename: Changlong
authors.initials: C
authors.lastname: Guo
authors.forename: Shuo
authors.initials: S
authors.lastname: Wang
authors.forename: Xingyu
authors.initials: X
authors.lastname: Wang
authors.forename: Lisha
authors.initials: L
authors.lastname: An
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Cao
authors.forename: Yue
authors.initials: Y
authors.lastname: Qiu
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000235:genetics*; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy
chemical_list: D002097:C-Reactive Protein