title: [Is perioperative chemotherapy effective in patients with resectable gastric cancer?].
abstract: Surgical procedures with curative intention have poor long-term results in patients with resectable gastric cancer. Searching in Epistemonikos database, which is maintained by screening 19 databases, we identified four systematic reviews including two pertinent randomised studies overall. We combined the evidence using meta-analysis and generated a summary of findings table following the GRADE approach. We conclude that the addition of perioperative chemotherapy to surgical resection increases survival in gastric cancer, probably in an important magnitude, and may not increase perioperative morbidity and mortality.
authors.affiliation: Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile; Centro del Cáncer, Departamento de Hemato-Oncología, Pontificia Universidad Católica de Chile; Fundación Epistemonikos. Address: Facultad de Medicina, Pontificia Universidad Católica de Chile, Lira 63, Santiago Centro, Chile. Email: jepena@uc.cl.
authors.forename: José
authors.initials: J
authors.lastname: Peña
authors.affiliation: Centro del Cáncer, Departamento de Hemato-Oncología, Pontificia Universidad Católica de Chile; Centro de Investigación Traslacional Oncológica (CITO).
authors.forename: Marcelo
authors.initials: M
authors.lastname: Garrido
authors.affiliation: Programa de Salud Basada en Evidencia, Facultad de Medicina, Pontificia Universidad Católica de Chile; Departamento de Medicina Interna, Facultad de Medicina, Pontificia Universidad Católica de Chile; GRADE working group; The Cochrane Collaboration; Fundación Epistemonikos.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Rada
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013274:Stomach Neoplasms / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents