title: Congenital hyperinsulinism.
abstract: Hyperinsulinism is the most common cause of hypoglycemia in infants. In many cases conservative treatment is not effective and surgical intervention is required. Differentiation between diffuse and focal forms and localization of focal lesions are the most important issues in preoperative management. We present a case of persistent infancy hyperinsulinism. Clinical presentation, conservative treatment modalities, diagnostic possibilities of focal and diffuse forms, and surgical treatment, which led to total recovery, are discussed.
authors.affiliation: Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: petraitiene.indre@yahoo.com.
authors.forename: Indrė
authors.initials: I
authors.lastname: Petraitienė
authors.affiliation: Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Giedrius
authors.initials: G
authors.lastname: Barauskas
authors.affiliation: Department of Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Antanas
authors.initials: A
authors.lastname: Gulbinas
authors.affiliation: Department of Pediatric Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Dalius
authors.initials: D
authors.lastname: Malcius
authors.affiliation: Great Ormond Street Hospital for Children NHS Trust and Institute of Child Health, University College London, London, UK.
authors.forename: Khalid
authors.initials: K
authors.lastname: Hussain
authors.affiliation: Children's Hospital, Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania.
authors.forename: Gilvydas
authors.initials: G
authors.lastname: Verkauskas
authors.affiliation: Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
authors.forename: Rasa
authors.initials: R
authors.lastname: Verkauskienė
mesh_terms: D018389:Codon, Nonsense; D003131:Combined Modality Therapy; D044903:Congenital Hyperinsulinism / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D064233:Sulfonylurea Receptors / Q000235:genetics; D016896:Treatment Outcome
chemical_list: C577507:ABCC8 protein, human; D018389:Codon, Nonsense; D064233:Sulfonylurea Receptors
keywords: (18)F-DOPA; Gene mutations; Hyperinsulinism; Hypoglycemia; PET scan