title: Traumatic head injury mimicking acute encephalopathy with biphasic seizures and late reduced diffusion.
abstract: Many studies have reported acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) associated with viral infection at onset, but few studies have reported AESD without infection. We report the case of a 9-month-old boy who had a clinical course mimicking AESD after a traffic accident. The traffic accident caused a mild subdural hematoma without neurological abnormalities on admission. The boy became unconscious on the second day, and he was diagnosed with non-convulsive status epilepticus on the third day. Diffusion-weighted imaging showed reduced water diffusion in the subcortical white matter. On laboratory analysis interleukin (IL)-6 was elevated in the cerebrospinal fluid (CSF), but not in the serum. He had severe neurological sequelae with mental retardation, spastic tetraplegia, and epilepsy. We suggest that brain damage mimicking AESD was caused by the traffic accident and the prolonged seizure during infancy.
authors.affiliation: Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Inoue
authors.forename: Shunji
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Madoka
authors.initials: M
authors.lastname: Kajimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsushige
authors.forename: Takashi
authors.initials: T
authors.lastname: Ichiyama
mesh_terms: D000208:Acute Disease; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis*; D006259:Craniocerebral Trauma / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D008297:Male; D012640:Seizures / Q000209:etiology
keywords: acute encephalopathy; brain injury; epilepsy; excitotoxicity; traffic accident