title: [Anti-p200/anti-laminin γ1 pemphigoid and BP180 NC16A/4575- positive mucous membrane pemphigoid : late diagnosis in a patient with disease-related loss of vision and multiple previous surgical interventions].
abstract: A 87-year-old woman presented with a three-year history of partially erosive, partially bullous skin and mucosal lesions, symblepharon of both eyelids as well as dysphagia. To date, multiple excisions of the skin lesions, which had been described as "skin tumors" by surgeons, had been performed. The synopsis of histology, direct and indirect immunofluorescence established the diagnosis of anti-p200/anti-laminin γ1 pemphigoid and BP180 NC16A/4575- positive mucous membrane pemphigoid with an unusual "epitope-spreading" phenomenon. Due to the late initiation of therapy, the disease-related loss of vision unfortunately was irreversible.
authors.affiliation: Klinik für Dermatologie und Allergologie, Klinikum Bremen-Mitte, St.-Jürgen-Str. 1, 28177, Bremen, Deutschland, Kjell.kaune@klinikum-bremen-mitte.de.
authors.forename: K M
authors.initials: KM
authors.lastname: Kaune
authors.forename: M
authors.initials: M
authors.lastname: Kasperkiewicz
authors.forename: D
authors.initials: D
authors.lastname: Tams
authors.forename: M
authors.initials: M
authors.lastname: Bergmann
authors.forename: M
authors.initials: M
authors.lastname: Zutt
mesh_terms: D000369:Aged, 80 and over; D001324:Autoantigens / Q000276:immunology; D001766:Blindness / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control*; D005142:Eyelid Neoplasms / Q000175:diagnosis / Q000601:surgery; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007797:Laminin / Q000276:immunology; D024041:Non-Fibrillar Collagens / Q000276:immunology; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis* / Q000276:immunology / Q000601:surgery*; D017211:Treatment Failure; D000097805:Collagen Type XVII
chemical_list: D001324:Autoantigens; D007797:Laminin; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII; C089141:laminin gamma 1