title: Effects of Bu-Shen-An-Tai recipe and its two components on endometrial morphology during peri-implantation in superovulated mice.
abstract: The aim of this study was to investigate the effect of Bu-Shen-An-Tai recipe (BSATR) and its two components (Bushen recipe, and Huoxue recipe) on endometrial morphology during peri-implantation in superovulated mice. Mice were randomly divided into five groups, including the normal (N), model (M), Bushen (BS), Huoxue (HX) and Bu-Shen-An-Tai (BH) groups. The uteri were collected on day 4 of pregnancy, and the endometrium thickness, microvessel density (MVD) and number of pinopodes observed. Compared with the M group, the endometrial thickness in the BS, HX and BH groups was significantly increased and there was a significant difference in endometrial thickness between the BS and the BH groups. The mean MVD was significantly lower in the M group than in the N group, and there was a significant increase in MVD in the BS, HX and BH groups as compared with the M group. Compared with the M group, the pinopode scores in the endometrium were significantly increased in the HX and BH groups; and the BS group had significantly higher pinipode scores than the HX and BH groups. In conclusion, the results of the present study demonstrated that the recipes (Bushen, Huoxue and BSATR) could improve the endometrial environment by regulating the endometrial thickness, MVD and the number of pinopodes at the window of implantation. Moreover, the Huoxue recipe and the BSATR were more efficient than the Bushen recipe, with the BSATR tending to have the most beneficial effects.
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Cui
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Cui-Hong
authors.initials: CH
authors.lastname: Zheng
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Gong
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wen
authors.affiliation: Institute of Integrated Traditional Chinese and Western Medicine, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Ma
authors.affiliation: Center of Experimental Animals, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Shun-Chang
authors.initials: SC
authors.lastname: Zhou
authors.affiliation: Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. mmzhang@tjh.tjmu.edu.cn.
authors.forename: Ming-Min
authors.initials: MM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D007150:Immunohistochemistry; D051379:Mice; D008855:Microscopy, Electron, Scanning; D055806:Microvessels / Q000378:metabolism / Q000502:physiology; D010060:Ovulation / Q000502:physiology*; D011247:Pregnancy; D011897:Random Allocation; D013997:Time Factors
chemical_list: D018952:Antigens, CD34; D004365:Drugs, Chinese Herbal; C534019:bushen antai