title: Chemoresistive gas sensors for the detection of colorectal cancer biomarkers.
abstract: Numerous medical studies show that tumor growth is accompanied by protein changes that may lead to the peroxidation of the cell membrane with consequent emission of volatile organic compounds (VOCs) by breath or intestinal gases that should be seen as biomarkers for colorectal cancer (CRC). The analysis of VOCs represents a non-invasive and potentially inexpensive preliminary screening technique. An array of chemoresistive gas sensors based on screen-printed metal oxide semiconducting films has been selected to discriminate gases of oncological interest, e.g., 1-iodononane and benzene, widely assumed to be biomarkers of colorectal cancer, from those of interference in the gut, such as methane and nitric oxide.
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. malagu@fe.infn.it.
authors.forename: Cesare
authors.initials: C
authors.lastname: Malagù
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. fbbbbr@unife.it.
authors.forename: Barbara
authors.initials: B
authors.lastname: Fabbri
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. gherardi@fe.infn.it.
authors.forename: Sandro
authors.initials: S
authors.lastname: Gherardi
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. giberti@fe.infn.it.
authors.forename: Alessio
authors.initials: A
authors.lastname: Giberti
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. guidi@fe.infn.it.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Guidi
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. nicolo.landini@student.unife.it.
authors.forename: Nicolò
authors.initials: N
authors.lastname: Landini
authors.affiliation: Department of Physics and Earth Science, University of Ferrara, Via Saragat 1/c, Ferrara 44122, Italy. giulia.zonta@unife.it.
authors.forename: Giulia
authors.initials: G
authors.lastname: Zonta
mesh_terms: D001554:Benzene / Q000302:isolation & purification*; D014408:Biomarkers, Tumor / Q000302:isolation & purification; D015374:Biosensing Techniques / Q000379:methods*; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D008401:Gas Chromatography-Mass Spectrometry; D005740:Gases / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D055549:Volatile Organic Compounds / Q000302:isolation & purification*
chemical_list: D014408:Biomarkers, Tumor; D005740:Gases; D055549:Volatile Organic Compounds; D001554:Benzene