title: [Neuroprotective effect of neuroglutam under conditions of activated free radical oxidation].
abstract: The neuroprotective properties of the novel glutamic acid derivative neiroglutam have been studied in vitro and in vivo. Neiroglutam demonstrated the protective action on 6-OH-dopamine neurotoxicity model <MI> in vitro, where free radical oxidation is a basic part of pathogenesis. In control rats, focal brain ischemia caused significant increase in thiobarbituric acid reactive species (TBARS) level and decrease in superoxide dismutase (SOD) enzyme activity. In two-year-old rats, preventive administration of the neiroglutam caused a significant reduction in the TBARS plasma concentration (34.5%, p < 0.05), increased SOD activity, and increased the time of acid-induced hemolysis of erythrocytes (40%, p < 0.05).
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: E V
authors.initials: EV
authors.lastname: Volotova
authors.forename: D V
authors.initials: DV
authors.lastname: Kurkin
authors.forename: D A
authors.initials: DA
authors.lastname: Bakulin
authors.forename: I O
authors.initials: IO
authors.lastname: Logvinov
authors.forename: T A
authors.initials: TA
authors.lastname: Antipova
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D004912:Erythrocytes / Q000187:drug effects; D005609:Free Radicals / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018698:Glutamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D016627:Oxidopamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D005609:Free Radicals; D018696:Neuroprotective Agents; D017392:Thiobarbituric Acid Reactive Substances; D018698:Glutamic Acid; D016627:Oxidopamine; D013482:Superoxide Dismutase