title: Relationship between serotonin and mast cells: inhibitory effect of anti-serotonin.
abstract: Serotonin (5-HT) is an important neurotransmitter that acts in both central and peripheral nervous system, and has an impact on cell proliferation, migration and apoptosis. 5HT exerts its effects via several receptors. Treatment with anti-5-HT receptors diminish the severity of contact allergy in experimental animals, an effect mediated by mast cells; while an agonist reduces the stress level and relieves pruritus in patients with atopic dermatitis. Mast cells are important for both innate and adaptive immunity and they are activated by cross-linking of FceRI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. Serotonin is present in murine mucosal mast cells and some authors reported that human mast cells may also contain serotonin, especially in subjects with mastocytosis. Here we report the interrelationship between mast cells, serotonin and its receptor inhibitor.
authors.affiliation: Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: S K
authors.initials: SK
authors.lastname: Kritas
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.affiliation: Nicola's Foundation, Onlus, Arezzo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.affiliation: Orthopedic Division, University of Chieti-Pescara, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pantalone
authors.affiliation: Gynecology Clinic, Pescara Hospital, Pescara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.affiliation: Nicola's Foundation, Onlus, Arezzo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tei
authors.affiliation: Nicola's Foundation, Onlus, Arezzo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Speziali
authors.affiliation: Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. d'Annunzio University Chieti-Pescara, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Saggini
authors.affiliation: Immunology Division, Medical School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Conti
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects*; D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects*; D018928:Immunity, Mucosal / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D008407:Mast Cells / Q000276:immunology*; D051379:Mice; D017455:Receptors, IgE / Q000276:immunology; D011985:Receptors, Serotonin / Q000276:immunology; D012701:Serotonin / Q000276:immunology*; D012702:Serotonin Antagonists / Q000494:pharmacology*
chemical_list: D018836:Inflammation Mediators; D017455:Receptors, IgE; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D007073:Immunoglobulin E