title: Diuretics and bioimpedance-measured fluid spaces in hypertensive patients.
abstract: The authors examined the relationship between thiazide-type diuretics and fluid spaces in a cohort of hypertensive patients in a retrospective study of 60 stable hypertensive patients without renal abnormalities who underwent whole-body bioimpedance analysis. Overhydration was greater in the diuretic group, but only to a nonsignificant degree (5.9 vs. 2.9%; P=.21). The total body water did not differ in the two groups (41.8 L vs. 40.5 L; P=.64). Extracellular fluid volume (ECV) (19.7 L vs. 18.5 L; P=.35) and intracellular fluid volume (ICV) spaces (20.8 L vs. 21.3 L; P=.75) were also not significantly different in the two groups. The ratio of ICV:ECV, however, appeared different: 1.05 vs 1.15 (P=.017) and the effect was maintained in the linear regression-adjusted model (β coefficient: -0.143; P=.001). The diuretic-related distortion of ICV:ECV ratio indicates potential fluid redistribution in hypertensive patients, with ICV participating in the process.
authors.affiliation: Fresenius Medical Care Hungary, Semmelweis University, Budapest, Hungary; Carolinas Campus, Edward Via Osteopathic College of Medicine, Spartanburg, SC.
authors.forename: Mihály
authors.initials: M
authors.lastname: Tapolyai
authors.forename: Mária
authors.initials: M
authors.lastname: Faludi
authors.forename: Neville R
authors.initials: NR
authors.lastname: Dossabhoy
authors.forename: István
authors.initials: I
authors.lastname: Barna
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Lengvárszky
authors.forename: Tibor
authors.initials: T
authors.lastname: Szarvas
authors.forename: Klára
authors.initials: K
authors.lastname: Berta
authors.forename: Tibor
authors.initials: T
authors.lastname: Fülöp
mesh_terms: D000368:Aged; D001826:Body Fluids / Q000187:drug effects* / Q000378:metabolism; D015331:Cohort Studies; D004232:Diuretics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D004232:Diuretics