title: Efficacy and safety of rituximab for myasthenia gravis: a systematic review and meta-analysis.
abstract: Myasthenia gravis is an autoimmune disorder of the neuromuscular junction caused by circulating antibodies specific for the post-synaptic acetylcholine receptor or, in a minority of cases, for the muscle-specific tyrosine-kinase and the low-density lipoprotein receptor-related protein 4. A wide range of symptomatic and immunosuppressive treatments is currently available for MG patients with variable outcome. However, most immunosuppressive treatments are characterized by delayed onset of action and in some cases are not sufficient to induce stable remission of the disease. Rituximab (RTX) is a chimaeric monoclonal antibody specific for the CD20 B-cell surface antigen. Recent studies have provided evidence that RTX may be an effective treatment for patients with myasthenia gravis (MG) who are refractory to standardized immunosuppressive therapy. We performed a systematic review and a meta-analysis of the efficacy and safety of RTX in myasthenia gravis considering the potential predictive factors related to patients' response to RTX in this disease.
authors.affiliation: Don Carlo Gnocchi ONLUS Foundation, Milan, Italy, iorio.raffaele@gmail.com.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Iorio
authors.forename: Valentina
authors.initials: V
authors.lastname: Damato
authors.forename: Paolo Emilio
authors.initials: PE
authors.lastname: Alboini
authors.forename: Amelia
authors.initials: A
authors.lastname: Evoli
mesh_terms: D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D009157:Myasthenia Gravis / Q000188:drug therapy*; D039781:PubMed / Q000706:statistics & numerical data; D000069283:Rituximab / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007155:Immunologic Factors; D000069283:Rituximab