title: Curcumin enhances the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells.
abstract: Curcumin is the major component of the yellow extract derived from the rhizome of the Curcuma longa, which is also a main bioactive polyphenol and has been generally used as a spice, food additive, and herbal medicine. In this presented study, we found that curcumin can enhance the production of major structural components of elastic fibers, elastin, and fibrillin-1, in normal human fibroblast cells via increasing ELN and FBN1 promoters' activities. With 2 μM curcumin treatment, the enhanced tropoelastin and fibrillin-1 protein amounts in Detroit 551 cells were approximately 134 and 130% of control, respectively. Therefore, our results demonstrated that curcumin may be used as a functional compound and applied to drugs, foods, and cosmetics in the future.
authors.affiliation: a Department of Cosmetic Science and Management, Mackay Medicine , Nursing and Management College , Taipei , Taiwan, ROC.
authors.forename: Shu-Mei
authors.initials: SM
authors.lastname: Lee
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Chiang
authors.forename: Hsun-Yen
authors.initials: HY
authors.lastname: Wang
authors.forename: Pey-Shiuan
authors.initials: PS
authors.lastname: Wu
authors.forename: Chih-Chien
authors.initials: CC
authors.lastname: Lin
mesh_terms: D000375:Aging / Q000187:drug effects; D002460:Cell Line; D003474:Curcumin / Q000494:pharmacology*; D004547:Elastic Tissue / Q000187:drug effects* / Q000378:metabolism*; D004549:Elastin / Q000096:biosynthesis* / Q000235:genetics; D000071838:Fibrillin-1; D000071837:Fibrillins; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D008840:Microfilament Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D011401:Promoter Regions, Genetic / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014333:Tropoelastin / Q000235:genetics / Q000378:metabolism; D054392:Adipokines
chemical_list: D003474:Curcumin; D004549:Elastin; D000071838:Fibrillin-1; D000071837:Fibrillins; D008840:Microfilament Proteins; D012333:RNA, Messenger; D014333:Tropoelastin; C000605722:FBN1 protein, human; D054392:Adipokines
keywords: curcumin; elastin; fibrillin-1; fibroblast cells; promoter activity