title: Longitudinal trends in HIV nonoccupational postexposure prophylaxis use at a Boston community health center between 1997 and 2013.
abstract: Secular trends in nonoccupational postexposure prophylaxis (NPEP) use have not been well characterized. We performed a retrospective longitudinal study of 894 electronic medical records of NPEP users, mostly men who have sex with men, at a Boston community health center who presented between July 1997 and August 2013. NPEP use and condomless sexual exposures increased over time; 19.4% had multiple NPEP courses. Having an HIV-infected partner was associated with increased odds of regimen completion, and 3-drug regimens were associated with decreased odds of completion. Targeted adherence and risk-reduction counseling are warranted for select NPEP users at this center.
authors.affiliation: *Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA; †The Fenway Institute, Boston, MA; ‡Harvard Medical School, Boston, MA; §Department of Epidemiology, Harvard School of Public Health, Boston, MA; and ‖Department of Psychiatry, Massachusetts General Hospital, Boston, MA.
authors.forename: Sachin
authors.initials: S
authors.lastname: Jain
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Oldenburg
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Mimiaga
authors.forename: Kenneth H
authors.initials: KH
authors.lastname: Mayer
mesh_terms: D000328:Adult; D001900:Boston; D003151:Community Health Centers / Q000458:organization & administration*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D008297:Male; D056990:Post-Exposure Prophylaxis