title: Brazilian Registry of Bone Biopsy (REBRABO): design, data elements and methodology.
abstract: BACKGROUND
  Mineral bone disorder (MBD) is a common condition in chronic kidney disease (CKD) patients and causes significant morbidity and mortality. Data involving prevalence of alterations in bone histological patterns, impact of different treatments and its repercussion in outcomes, such as bone fractures, hospitalization, cardiovascular disease and mortality, are scarce. Data bank registry can be a valuable tool to understand epidemiological aspects of MBD CKD. The Brazilian Registry of Bone Biopsy (REBRABO) will be a national registry, coordinating by the Brazilian Society of Nephrology - Committee of MBD-CKD.
  
  
  OBJECTIVE
  To describe REBRABO's design, elements of data and methodology.
  
  
  METHODS
  Will be an online national observational and multicentric data registry divided in two phases (retrospective, 1st phase) and prospective (2nd phase), including information from bone tissue histomorphometric analysis and demographics, clinical and laboratorial data from CKD-MBD patients.
  
  
  RESULTS
  The REBRABO's first phase will explore data on demographics, clinical, laboratorial and bone histomorphometric analysis data from January/1986 to December/2013. The first RESULTS are expected in early 2015.
  
  
  CONCLUSIONS
  Studies in the field of CKD-MBD are needed, particularly those analyzing its prevalence, associations between demographic, clinical, histological parameters, and major outcomes. The REBRABO will be a unique retrospective and prospective research platform including bone biopsy data in CKD-MBD patients.
authors.affiliation: Universidade de São Paulo.
authors.forename: Rodrigo Bueno
authors.initials: RB
authors.lastname: de Oliveira
authors.affiliation: Pontifícia Universidade Católica do Paraná.
authors.forename: Fellype Carvalho
authors.initials: FC
authors.lastname: Barreto
authors.affiliation: Universidade de São Paulo.
authors.forename: Melani Ribeiro
authors.initials: MR
authors.lastname: Custódio
authors.affiliation: Universidade Federal de Pernambuco.
authors.forename: José Edvanilson Barros
authors.initials: JE
authors.lastname: Gueiros
authors.affiliation: Hospital Ana Neri.
authors.forename: Carolina Lara
authors.initials: CL
authors.lastname: Neves
authors.affiliation: Hospital das Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul.
authors.forename: Cristina
authors.initials: C
authors.lastname: Karohl
authors.affiliation: Universidade Federal Fluminense.
authors.forename: Elisa de Albuquerque
authors.initials: Ede A
authors.lastname: Sampaio
authors.affiliation: Universidade de São Paulo.
authors.forename: Rackel Mota
authors.initials: RM
authors.lastname: da Costa
authors.affiliation: Universidade Federal de São Paulo.
authors.forename: Maria Eugênia Fernandes
authors.initials: ME
authors.lastname: Canziani
authors.affiliation: Universidade de São Paulo.
authors.forename: Rosa Maria Afonso
authors.initials: RM
authors.lastname: Moysés
authors.affiliation: Universidade Federal de São Paulo.
authors.forename: Aluízio Barbosa
authors.initials: AB
authors.lastname: de Carvalho
authors.affiliation: Universidade de São Paulo.
authors.forename: Vanda
authors.initials: V
authors.lastname: Jorgetti
mesh_terms: D001706:Biopsy; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology*; D001938:Brazil; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D011996:Records; D012042:Registries; D012107:Research Design