title: Development, optimization and evaluation of polymeric electrospun nanofiber: A tool for local delivery of fluconazole for management of vaginal candidiasis.
abstract: The present study is designed to explore the localized delivery of fluconazole using mucoadhesive polymeric nanofibers. Drug-loaded polymeric nanofibers were fabricated by the electrospinning method using polyvinyl alcohol (PVA) as the polymeric constituent. The prepared nanofibers were found to be uniform, non-beaded and non-woven, with the diameter of the fibers ranging from 150 to 180 nm. Further drug release studies indicate a sustained release of fluconazole over a period of 6 h. The results of studies on anti-microbial activity indicated that drug-loaded polymeric nanofibers exhibit superior anti-microbial activity against Candida albicans, when compared to the plain drug.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Sharma
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Tarun
authors.initials: T
authors.lastname: Garg
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Amit K
authors.initials: AK
authors.lastname: Goyal
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Goutam
authors.initials: G
authors.lastname: Rath
mesh_terms: D000268:Adhesiveness; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D002177:Candidiasis / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D005260:Female; D015725:Fluconazole / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007779:Lactobacillus acidophilus / Q000187:drug effects; D008422:Materials Testing; D009092:Mucous Membrane / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013718:Tensile Strength; D014623:Vaginal Diseases / Q000188:drug therapy*; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004337:Drug Carriers; D014867:Water; D015725:Fluconazole; D011142:Polyvinyl Alcohol
keywords: Vaginal candidiasis; electrospinning; fluconazole; nanofiber