title: Expedient synthesis of chiral α-amino acids through nickel-catalyzed reductive cross-coupling.
abstract: A novel method for the synthesis of non-natural L- and D-amino acids by a Ni-catalyzed reductive cross-coupling reaction is described. This strategy enables the racemization-free cross-coupling of serine/homoserine- derived iodides with aryl/acyl/alkyl halides. It provides convenient access to varieties of enantiopure and functionalized amino acids, which are important building blocks in bioactive compounds and pharmaceuticals.
authors.affiliation: Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China); State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000 (China); Department of Chemistry, Tsinghua University, Beijing 100084 (China).
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Jun
authors.initials: J
authors.lastname: Yi
authors.forename: Zhen-Qi
authors.initials: ZQ
authors.lastname: Zhang
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Dai
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Xiao
authors.forename: Yao
authors.initials: Y
authors.lastname: Fu
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D006219:Halogens / Q000737:chemistry; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D058451:Oxidative Coupling; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D006219:Halogens; D009532:Nickel
keywords: CC bond formation; amino acids; catalysis; nickel; reductive cross-coupling