title: Expression of interleukin-22 and its significance in the pathogenesis of chronic rhinosinusitis.
abstract: In order to explore the role of IL-22 in the pathogenesis of CRS, we observed the expression of IL-22 and associated factors in chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Immunohistochemical staining was applied to detect the expression of IL-22, IL-22R, STAT3, retinoic acid orphan receptor C (RORC) and aryl hydrocarbon recptor (AhR). There was significantly higher expression of IL-22 in CRSsNP than in controls (P<0.05). But the expression of IL-22 had no significant difference when comparing CRSwNP with CRSsNP and controls. The expression of IL-22R was significantly lower in CRSwNP compared to controls and CRSsNP (P<0.05). The expression of AhR was lower in CRSwNP than in CRSsNP (P<0.05). There was no significant difference of RORC and STAT3 among CRSwNP, CRSsNP and controls. IL-22 plays the important role in the pathogenesis of CRS, and further research is needed to understand the complex interactions with other cytokines and the exact mechanism of transcriptional regulation for IL-22.
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical University Harbin, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical University Harbin, China.
authors.forename: Mi
authors.initials: M
authors.lastname: Gao
authors.affiliation: Department of Otorhinolaryngology, The People's Hospital of Hailin City Hailin, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical University Harbin, China.
authors.forename: Huamin
authors.initials: H
authors.lastname: Guo
authors.affiliation: Department of Otorhinolaryngology & Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical University Harbin, China.
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D051792:Basic Helix-Loop-Helix Proteins / Q000032:analysis; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007378:Interleukins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000276:immunology*; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000032:analysis; D018336:Receptors, Aryl Hydrocarbon / Q000032:analysis; D018123:Receptors, Interleukin / Q000032:analysis; D012220:Rhinitis / Q000175:diagnosis / Q000276:immunology*; D050796:STAT3 Transcription Factor / Q000032:analysis; D012852:Sinusitis / Q000175:diagnosis / Q000276:immunology*; D055815:Young Adult; D000097043:Interleukin-22
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018336:Receptors, Aryl Hydrocarbon; D018123:Receptors, Interleukin; D050796:STAT3 Transcription Factor; D000097043:Interleukin-22; C111235:AHR protein, human; C539900:RORC protein, human; C494086:STAT3 protein, human; C415369:interleukin-22 receptor
keywords: Chronic rhinosinusitis; IL-22; IL-22 receptor; aryl hydrocarbon recptor