title: Regular intermittent bolus provides similar incidence of maternal fever compared with continuous infusion during epidural labor analgesia.
abstract: OBJECTIVE
  To compare the effects of regular intermittent bolus versus continuous infusion for epidural labor analgesia on maternal temperature and serum interleukin-6 (IL-6) level.
  
  
  METHODS
  This randomized trial was performed in Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, China between October 2012 and February 2014. Either regular intermittent bolus (RIB, n=66) or continuous infusion (CI, n=66) was used for epidural labor analgesia. A bolus dose (10 ml of 0.08% ropivacaine + 0.4 ug·ml-1 sufentanil) was manually administrated once an hour in the RIB group, whereas the same solution was continuously infused at a constant rate of 10 ml·h-1 in the CI group. Maternal tympanic temperature and serum IL-6 level were measured hourly from baseline to one hour post partum. The incidences of fever (&gt;/=38 degree celsius ) were calculated.
  
  
  RESULTS
  The incidence of maternal fever was similar between the 2 groups. There was a rising trend in mean temperature over time in both groups, but no statistical difference was detected between the groups at respective time points; maternal serum IL-6 showed similar changes.
  
  
  CONCLUSIONS
  Compared with continuous infusion, regular intermittent bolus presents with the same incidence of maternal fever for epidural labor analgesia. Interleukin-6 elevation could be involved in mean maternal temperature increase.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. E-mail. shanwufeng@163.com.
authors.forename: Shan-Wu
authors.initials: SW
authors.lastname: Feng
authors.forename: Shi-Qin
authors.initials: SQ
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Cai-Juan
authors.initials: CJ
authors.lastname: Li
authors.forename: Xian
authors.initials: X
authors.lastname: Wang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Yuan
authors.forename: Fu-Zhou
authors.initials: FZ
authors.lastname: Wang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Shen
authors.forename: Zheng-Nian
authors.initials: ZN
authors.lastname: Ding
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage*; D015360:Analgesia, Epidural / Q000379:methods; D016362:Analgesia, Obstetrical / Q000379:methods; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005334:Fever / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D060186:Infusions, Spinal; D015850:Interleukin-6 / Q000097:blood*; D007744:Obstetric Labor Complications / Q000097:blood / Q000453:epidemiology*; D011247:Pregnancy; D000077212:Ropivacaine; D017409:Sufentanil / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; C508600:IL6 protein, human; D015850:Interleukin-6; D000077212:Ropivacaine; D017409:Sufentanil