title: Plerixafor: what we still have to learn.
abstract: Plerixafor, a hematopoietic stem cell mobilizer, is indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. Current evidence suggests that the addition of plerixafor with chemotherapy plus G-CSF is safe and effective in the large majority of the patients with low blood CD34(+) cell count after mobilization and/or poor yield after the first collection. Nevertheless, there are several questions strongly debated, and in this paper, we would like to identify areas of possible future use and development of the drug.
authors.affiliation: Hematology Institute, Hospital of Cremona , Cremona , Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lanza
authors.forename: Angelo
authors.initials: A
authors.lastname: Gardellini
authors.forename: Daniele
authors.initials: D
authors.lastname: Laszlo
authors.forename: Massimo
authors.initials: M
authors.lastname: Martino
mesh_terms: D001596:Benzylamines; D000080027:Cyclams; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006571:Heterocyclic Compounds / Q000008:administration & dosage*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D009101:Multiple Myeloma / Q000628:therapy; D009765:Obesity / Q000150:complications / Q000628:therapy; D050177:Overweight / Q000150:complications / Q000628:therapy; D018579:Patient Selection; D014182:Transplantation, Autologous
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D016179:Granulocyte Colony-Stimulating Factor; C088327:plerixafor
keywords: autologous transplantation; mobilization; peripheral blood stem cells; plerixafor