title: ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone.
abstract: Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. As with all sarcomas, the prognosis of these diseases ultimately depends on the presence of metastatic disease. Survival is therefore closely linked with the biology and metastatic potential of a particular bone tumor's cells. Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, cultured human CSA cells, which are historically chemo- and radio-resistant, may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to draw broad conclusions from such a small series, the importance of ALDH activity and inhibition in the metastatic potential of primary bone sarcomas should be investigated further.
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Greco
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Trevor
authors.initials: T
authors.lastname: Schott
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Mu
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Adam
authors.initials: A
authors.lastname: Rothenberg
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Clifford
authors.initials: C
authors.lastname: Voigt
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: McGough
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Goodman
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Johnny
authors.initials: J
authors.lastname: Huard
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, USA ; Cancer Stem Cell Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, USA ; University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, USA.
authors.forename: Kurt R
authors.initials: KR
authors.lastname: Weiss
keywords: Aldehyde Dehydrogenase; Chondrosarcoma; Ewings Sarcoma; Metastases; Osteosarcoma