title: Relevance of LIG4 gene polymorphisms with cancer susceptibility: evidence from a meta-analysis.
abstract: Polymorphisms of LIG4 gene may influence DNA repair ability, thus altering the genetic stability and resulting in carcinogenesis. A growing number of studies have investigated the relevance of LIG4 T9I (rs1805388) and D501D (rs1805386) polymorphisms with cancer risk, however, the results are conflicting. To obtain a comprehensive conclusion, we searched relevant literatures from PubMed, Web of Science, Ovid and Embase databases on May 15, 2014 and performed a meta-analysis. In this meta-analysis, a total of 17 articles were included. Of them, there were 15 studies with 5873 cases and 5771 controls for rs1805388 and 6 studies with 4161 cases and 4881 controls for rs1805386. Overall, our results suggested that there was no obvious relevance of LIG4 T9I polymorphism with cancer susceptibility. However, in subgroup analysis, we found the LIG4 T9I was associated with a slightly decreased cancer risk among Caucasians. As to the rs1805386, the genetic variant had no significant association with cancer risk. In conclusion, despite several limitations, this meta-analysis suggested that LIG4 T9I genetic variant is associated with a decreased risk of cancer among Caucasians, however, the rs1805386 gene polymorphism is not a risk factor of cancer.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and hospital of Stomatology, Beijing 100081, China.
authors.forename: Shang
authors.initials: S
authors.lastname: Xie
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and hospital of Stomatology, Beijing 100081, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Shan
authors.affiliation: Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Shang
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and hospital of Stomatology, Beijing 100081, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong, China.
authors.forename: Jing
authors.initials: J
authors.lastname: He
authors.affiliation: Department of Oral and Maxillofacial Surgery, Peking University School and hospital of Stomatology, Beijing 100081, China.
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Cai
mesh_terms: D063646:Carcinogenesis / Q000235:genetics*; D000072481:DNA Ligase ATP; D011088:DNA Ligases / Q000235:genetics*; D004198:Disease Susceptibility; D056726:Genetic Association Studies; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: C000607893:LIG4 protein, human; D011088:DNA Ligases; D000072481:DNA Ligase ATP