title: Design of a customized multipurpose nano-enabled implantable system for in-vivo theranostics.
abstract: The first part of this paper reviews the current development and key issues on implantable multi-sensor devices for in vivo theranostics. Afterwards, the authors propose an innovative biomedical multisensory system for in vivo biomarker monitoring that could be suitable for customized theranostics applications. At this point, findings suggest that cross-cutting Key Enabling Technologies (KETs) could improve the overall performance of the system given that the convergence of technologies in nanotechnology, biotechnology, micro&amp;nanoelectronics and advanced materials permit the development of new medical devices of small dimensions, using biocompatible materials, and embedding reliable and targeted biosensors, high speed data communication, and even energy autonomy. Therefore, this article deals with new research and market challenges of implantable sensor devices, from the point of view of the pervasive system, and time-to-market. The remote clinical monitoring approach introduced in this paper could be based on an array of biosensors to extract information from the patient. A key contribution of the authors is that the general architecture introduced in this paper would require minor modifications for the final customized bio-implantable medical device.
authors.affiliation: Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain. ejuanola@el.ub.edu.
authors.forename: Esteve
authors.initials: E
authors.lastname: Juanola-Feliu
authors.affiliation: Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain.
authors.forename: Pere Ll
authors.initials: PL
authors.lastname: Miribel-Català
authors.affiliation: Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain. cpaezaviles@el.ub.edu.
authors.forename: Cristina
authors.initials: C
authors.lastname: Páez Avilés
authors.affiliation: Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain. jcolomer@el.ub.edu.
authors.forename: Jordi
authors.initials: J
authors.lastname: Colomer-Farrarons
authors.affiliation: Department of Public Economy, Political Economy and Spanish Economy, University of Barcelona, Av. Diagonal 690-696, Barcelona 08034, Spain. manel.gonzalez@ub.edu.
authors.forename: Manel
authors.initials: M
authors.lastname: González-Piñero
authors.affiliation: Department of Electronics, Bioelectronics and Nanobioengineering Research Group (SIC-BIO), University of Barcelona, Martí i Franquès 1, Barcelona 08028, Spain. jsamitier@ibecbarcelona.eu.
authors.forename: Josep
authors.initials: J
authors.lastname: Samitier
mesh_terms: D001672:Biocompatible Materials; D015374:Biosensing Techniques; D006801:Humans; D036103:Nanotechnology; D019736:Prostheses and Implants
chemical_list: D001672:Biocompatible Materials