title: Sequence variants of the HTR3A gene contribute to the genetic prediction of postoperative nausea in Taiwan.
abstract: Postoperative nausea (PON) is a common complication, and therefore, it is important to identify the associated genetic factors and the candidate predictive markers. Current clinical and basic research suggests that the 5-hydroxytryptamine type 3A receptor (HTR3A) may be important in the occurrence of PON. The association between three single nucleotide polymorphisms (SNPs) of the HTR3A gene and PON was examined to determine whether this can be used to predict the incidence of PON in a unique Taiwanese population without any reported postoperative nausea and vomiting (PONV) risk factors associated with PON occurrence. One thousand adult surgical patients who received general anesthesia were included in this analysis. A total of 369 patients were finally selected for a two-stage association study. Significant single-locus associations for all three HTR3A SNPs and PON were identified in both stages. In addition, two of the most common haplotypes, CTT and TAG, showed both a significant risk for and a protective effect against PON, respectively. Our findings support the notion that different haplotypes of HTR3A have reciprocal effects in the etiology of PON. Therefore specific haplotypes of HTR3A may be useful as predictors of PON for 24 h immediately after surgery in our population.
authors.affiliation: Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
authors.forename: Yi-Mei
authors.initials: YM
authors.lastname: Joy Lin
authors.affiliation: Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
authors.forename: Cheng-Da
authors.initials: CD
authors.lastname: Hsu
authors.affiliation: Department of Medical Research, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
authors.forename: Hsiao-Yen
authors.initials: HY
authors.lastname: Hsieh
authors.affiliation: Department of Anesthesiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.
authors.forename: Chia-Chih Alex
authors.initials: CC
authors.lastname: Tseng
authors.affiliation: Institute of Basic Medical Sciences and Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan.
authors.forename: H Sunny
authors.initials: HS
authors.lastname: Sun
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced / Q000235:genetics* / Q000503:physiopathology; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics*; D012307:Risk Factors; D013624:Taiwan
chemical_list: C509409:HTR3A protein, human; D044406:Receptors, Serotonin, 5-HT3