title: Hypercholesterolemia is Accounted for Atherosclerosis at the Proximal Arterial Segments of Myocardial Bridging: A Pilot Study.
abstract: Arterial shear stress was generally implicated in the development of atherosclerotic plaque (AP). Atherosclerotic plaque may be associated with myocardial bridging (MB). We evaluated the metabolic abnormalities which could determine the localization of AP at the proximal coronary segment of MB. We analyzed the patients with MB, AP&MB, and AP on left anterior descending (LAD) artery who were diagnosed by multislice computed tomography coronary angiography. Serum levels of metabolic parameters were compared among study groups. Patients with MB&AP and AP were significantly older than those in the MB group. Patients with MB&AP had AP and MB at the proximal and middle segments of LAD artery, respectively. Total cholesterol, low-density lipoprotein (LDL) cholesterol and very LDL, and triglyceride levels were significantly higher in patients with MB&AP and AP compared to only MB. Low-density lipoprotein cholesterol was significantly correlated with the type of coronary artery disease in multiple regression analysis. Myocardial bridging may be an anatomical determinant for the localization of AP proximal to itself in the presence of hypercholesterolemia.
authors.affiliation: Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Aparci
authors.affiliation: Department of Cardiology, Gulhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Cardiology, Eskisehir Military Hospital, Ankara, Turkey drsevketb@gmail.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Cardiology, Etimesgut Military Hospital, Ankara, Turkey.
authors.forename: Sercan
authors.initials: S
authors.lastname: Okutucu
authors.affiliation: Department of Cardiology, Haydarpasa Training Medicine, Istanbul, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Isilak
mesh_terms: D000328:Adult; D008078:Cholesterol, LDL / Q000097:blood; D015243:Cholesterol, VLDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D054084:Myocardial Bridging / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D014280:Triglycerides
keywords: atherosclerosis; hypercholesterolemia; hyperlipidemia; myocardial bridging