title: An efficient synthesis of 3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline, a promising radioprotector for cancer radiotherapy.
abstract: Nitroxides can ameliorate the toxic effects of radiation during cancer therapy. Nitroxides are paramagnetic and can be used in magnetic resonance imaging (MRI) and electron paramagnetic resonance imaging (EPRI) to monitorin vivooxidative stress status. Compound5(3-(N-piperidinemethyl)-2, 2, 5, 5-tetramethyl-1-oxy-3-pyrroline) was found to be the most effective nitroxide radioprotector. An efficient synthesis for this promising radioprotector was developed.
authors.affiliation: Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health.
authors.forename: Haitao
authors.initials: H
authors.lastname: Wu
authors.affiliation: Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health.
authors.forename: Vincent
authors.initials: V
authors.lastname: Coble
authors.affiliation: Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health.
authors.forename: Olga
authors.initials: O
authors.lastname: Vasalatiy
authors.affiliation: Imaging Probe Development Center, National Heart, Lung, and Blood Institute, National Institutes of Health.
authors.forename: Rolf E
authors.initials: RE
authors.lastname: Swenson
authors.affiliation: Radiation Biology Branch, Center for Cancer Research, National Cancer Institute. National Institutes of Health.
authors.forename: Murali C
authors.initials: MC
authors.lastname: Krishna
authors.affiliation: Radiation Biology Branch, Center for Cancer Research, National Cancer Institute. National Institutes of Health.
authors.forename: James B
authors.initials: JB
authors.lastname: Mitchell
keywords: EPRI; MRI; Nitroxide; radioprotector; redox