title: Cardiovascular Risk Factors in Young Patients of Coronary Artery Disease: Differences over a Decade.
abstract: BACKGROUND
  Studies evaluating temporal trends of Coronary artery disease (CAD) in young patients, from the India, are still lacking. The aim of this study was to evaluate temporal differences in risk factors of young patients of CAD over a decade.
  
  
  METHODS
  This is a single centre retrospective study performed in a tertiary care teaching institution in North India. Case records of young patients (≤40 years) with acute coronary syndrome between January 2000 to December 2001 and January 2009 to December 2010 were obtained. Records were sought for active smoking, family history, waist size, blood pressure, hypertension, fasting and postprandial blood sugar and lipid profile for both groups and analyzed using SPSS v.17. For the purpose of the study, p value <0.05 was considered statistically significant.
  
  
  RESULTS
  Medical records of a total of 79 and 83 patients with young CAD (≤40 years) were obtained for 2000-01 and 2009-10 period respectively. An increase in proportion of female patients, hypertension (p=0.004), dysglycemia (p<0.001), family history (p=0.01), metabolic syndrome (p<0.001), low high density lipoprotein (HDL) (p=0.07) and mean waist size (0.03) was noted over the years. Among males, increase in number of dysglycemics (p=0.0002), positive family history (p<0.0001) and mean waist size (0.032) was statistically significant.
  
  
  CONCLUSIONS
  Over a decade the patients with young CAD in our study, there was an increase in proportion of patients with metabolic syndrome, dysglycemia and low HDL.
authors.affiliation: Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
authors.forename: Amitesh
authors.initials: A
authors.lastname: Aggarwal
authors.affiliation: Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
authors.forename: Sourabh
authors.initials: S
authors.lastname: Aggarwal
authors.affiliation: Department of Medicine, University College of Medical Sciences (University of Delhi) and GTB Hospital, Delhi, India.
authors.forename: Vishal
authors.initials: V
authors.lastname: Sharma
keywords: Coronary Artery Disease; Diabetes Mellitus; Dyslipidemia; Hypertension; Smoking