title: Phase-transition contrast nanocapsules triggered by low-intensity ultrasound.
abstract: A polymeric nanocapsule encapsulated with 1,1,1,3,3-pentafluorobutane was developed, in which 2,2,3,3,4,4,4-heptafluoro-1-butyl groups were introduced to the polymer terminal for high loading of liquid fluorocarbon. In vitro experiments demonstrate that its liquid/gas-phase transition can be triggered by mild heating. This nanocapsule can be harnessed as a contrast agent for tumor imaging under diagnostic ultrasound.
authors.affiliation: School of Engineering, Sun Yat-Sen University, Guangzhou 510006, P. R. China. zhchao9@mail.sysu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Li
authors.forename: Jianhao
authors.initials: J
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.forename: Fangfang
authors.initials: F
authors.lastname: Song
authors.forename: Tinghui
authors.initials: T
authors.lastname: Yin
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhou
authors.forename: Rongqing
authors.initials: R
authors.lastname: Zheng
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005466:Fluorocarbons / Q000737:chemistry; D005740:Gases / Q000737:chemistry; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D005740:Gases; D053769:Nanocapsules; D011108:Polymers