title: Prognostic value of cyclin B in endometrial endometrioid adenocarcinoma.
abstract: Cyclins are a group of cell cycle regulatory proteins. Cyclin B acts as an activator to cyclin-dependent kinase 1 (CDK1), a protein kinase essential for G2/M phase transition. Deregulation of cyclins has been linked to a number of malignant neoplasms, but the impact on clinicopathological parameters seems to be cancer-specific. Overexpression of cyclin B has been shown to affect survival in some malignant tumors, including breast and esophageal cancer, but its impact on endometrial cancer has not been extensively studied. For this study, 211 endometrial endometrioid adenocarcinoma samples were obtained from patients surgically treated at the Oulu University Hospital. The samples were immunohistochemically stained and analyzed for cyclin B expression. The relationships between cyclin B expression and conventional prognostic factors were analyzed. A discrimination threshold for survival analyses was calculated by utilizing the receiver operator characteristic (ROC) method. Cyclin B expression correlated with grade and advanced stage. Survival analyses showed that cyclin B expression affects cancer-specific survival in univariate analysis. In multivariate analysis, the results were indicative that cyclin B may hold independent prognostic significance, but further studies are required to assess this.
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, P.O. Box 24, FI-90029, Oulu, Finland.
authors.forename: Simi
authors.initials: S
authors.lastname: Santala
authors.forename: Anne
authors.initials: A
authors.lastname: Talvensaari-Mattila
authors.forename: Ylermi
authors.initials: Y
authors.lastname: Soini
authors.forename: Markku
authors.initials: M
authors.lastname: Santala
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D016203:CDC2 Protein Kinase; D018269:Carcinoma, Endometrioid / Q000235:genetics* / Q000473:pathology; D019926:Cyclin B / Q000096:biosynthesis*; D018844:Cyclin-Dependent Kinases / Q000235:genetics; D005260:Female; D059565:G2 Phase Cell Cycle Checkpoints / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D019926:Cyclin B; D016203:CDC2 Protein Kinase; C528899:CDK1 protein, human; D018844:Cyclin-Dependent Kinases