title: Insecticidal and genotoxic potential of two semi-synthetic derivatives of dillapiole for the control of Aedes (Stegomyia) aegypti (Diptera: Culicidae).
abstract: The effects of two semi-synthetic dillapiole derivatives, ethyl-ether dillapiole and n-butyl ether dillapiole, on eggs and larvae of Aedes aegypti were studied in view of the need for expansion and renovation of strategic action to control this mosquito - the vector of Dengue virus -, which currently shows a high resistance to chemical insecticides. Eggs and third-instar larvae of A. aegypti that had been exposed to different concentrations of these two compounds showed toxicity and susceptibility, with 100% mortality. Classical cytogenetic assays showed genotoxicity caused by the two compounds in A. aegypti from the cumulative effect of nuclear abnormalities, indicating that these derivatives may be potential alternatives to control A. aegypti.
authors.affiliation: Post-Graduation Program in Genetics, Conservation and Evolutionary Biology/Instituto Nacional de Pesquisas da Amazônia - INPA, Brazil. Electronic address: pedro.domingos@inpa.gov.br.
authors.forename: Pedro Rauel Cândido
authors.initials: PR
authors.lastname: Domingos
authors.affiliation: Laboratory of Vectors of Malaria and Dengue/CPCS/INPA, Manaus, AM, Brazil. Electronic address: ana.pinto@inpa.gov.br.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: da Silva Pinto
authors.affiliation: Laboratory of Vectors of Malaria and Dengue/CPCS/INPA, Manaus, AM, Brazil. Electronic address: jsantos@inpa.gov.br.
authors.forename: Joselita Maria Mendes
authors.initials: JM
authors.lastname: dos Santos
authors.affiliation: Laboratory of Vectors of Malaria and Dengue/CPCS/INPA, Manaus, AM, Brazil. Electronic address: msrafael@inpa.gov.br.
authors.forename: Míriam Silva
authors.initials: MS
authors.lastname: Rafael
mesh_terms: D000330:Aedes / Q000378:metabolism* / Q000821:virology; D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004249:DNA Damage; D003716:Dengue Virus / Q000378:metabolism; D004149:Dioxoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D007303:Insect Vectors / Q000378:metabolism* / Q000821:virology; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000498:Allyl Compounds; D004149:Dioxoles; D007306:Insecticides; C498255:5-allyl 6,7-dimethoxy 1,3-benzodioxole
keywords: Bio-insecticide; Bioassay; Biological control; Dengue virus; Essential oil