title: Short time to first void is associated with lower whole-night sleep quality in nocturia patients.
abstract: OBJECTIVE
  To examine associations between diary-based reports of the time to first void and a commonly used measure of sleep across the entire night, the Pittsburgh Sleep Quality Index (PSQI).
  
  
  METHODS
  Data from the Baseline phase of a large, multi-site, US-based, randomized clinical trial of a nocturia medication were analyzed. We examined age-adjusted associations between time to first void as reported in a 3-day diary and PSQI Global and individual subscale scores.
  
  
  METHODS
  757 patients with nocturia completing Baseline measurements.
  
  
  METHODS
  None.
  
  
  RESULTS
  Using quartile analysis, higher scores indicating poorer sleep on all PSQI scales were associated (p's ≤ 0.05) with short time to first void durations. Among individuals in the lowest quartile of time to first void (< 1.17 hours), the odds ratio (OR) of a PSQI Global score > 5 was nearly 3 times (2.96; 95% CI 1.75-5.01) that of those in the highest quartile (> 2.50 h). Shorter time to first void was associated with lower sleep quality, shorter sleep duration, poorer sleep efficiency, and greater daytime dysfunction.
  
  
  CONCLUSIONS
  Time to first void may serve as a valuable adjunctive, self-report measure for characterizing poor sleep among populations with nocturia.
authors.affiliation: Program in Sleep Medicine, Emory University School of Medicine, Atlanta, GA.
authors.forename: Donald L
authors.initials: DL
authors.lastname: Bliwise
authors.affiliation: Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
authors.forename: Tove
authors.initials: T
authors.lastname: Holm-Larsen
authors.affiliation: Global Research and Development, Ferring Pharmaceuticals, Copenhagen, Denmark.
authors.forename: Sandra
authors.initials: S
authors.lastname: Goble
authors.affiliation: Global Research and Development, Ferring Pharmaceuticals, Copenhagen, Denmark.
authors.forename: Jens Peter
authors.initials: JP
authors.lastname: Nørgaard
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053158:Nocturia / Q000150:complications* / Q000503:physiopathology; D057566:Self Report; D007319:Sleep Initiation and Maintenance Disorders / Q000150:complications* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
keywords: PSQI; insomnia; nocturia; nocturnal micturition; self-reports