title: Zinc(II) complexation by some biologically relevant pH buffers.
abstract: The isothermal titration calorimetry (ITC) technique supported by potentiometric titration data was used to study the interaction of zinc ions with pH buffer substances, namely 2-(N-morpholino)ethanesulfonic acid (Mes), piperazine-N,N'-bis(2-ethanesulfonic acid) (Pipes), and dimethylarsenic acid (Caco). The displacement ITC titration method with nitrilotriacetic acid as a strong, competitive ligand was applied to determine conditional-independent thermodynamic parameters for the binding of Zn(II) to Mes, Pipes, and Caco. Furthermore, the relationship between the proposed coordination mode of the buffers and the binding enthalpy has been discussed.
authors.affiliation: Faculty of Chemistry, University of Gdańsk, Wita Stwosza, 63, 80-308, Gdańsk, Poland.
authors.forename: D
authors.initials: D
authors.lastname: Wyrzykowski
authors.forename: A
authors.initials: A
authors.lastname: Tesmar
authors.forename: D
authors.initials: D
authors.lastname: Jacewicz
authors.forename: J
authors.initials: J
authors.lastname: Pranczk
authors.forename: L
authors.initials: L
authors.lastname: Chmurzyński
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry*; D002021:Buffers; D002151:Calorimetry; D006863:Hydrogen-Ion Concentration; D009025:Morpholines / Q000737:chemistry*; D009571:Nitrilotriacetic Acid / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011522:Protons; D012996:Solutions; D013816:Thermodynamics; D015032:Zinc / Q000737:chemistry*
chemical_list: D017738:Alkanesulfonic Acids; D002021:Buffers; D009025:Morpholines; D010879:Piperazines; D011522:Protons; D012996:Solutions; C004550:2-(N-morpholino)ethanesulfonic acid; C008916:piperazine-N,N'-bis(2-ethanesulfonic acid); D015032:Zinc; D009571:Nitrilotriacetic Acid
keywords: Zn(II) complexes; buffer; competitive binding; isothermal titration calorimetry; thermodynamic parameters