title: [Indoleamine 2,3-dioxygenase activity in breast cancer patients with local recurrence or distant metastases].
abstract: We evaluated the significance of indoleamine 2,3-dioxygenase(IDO)activity in breast cancer patients with local recurrence or distant metastases. IDO activity can be determined using the tryptophan/kynurenine(Trp/Kyn)ratio. Trp and Kyn were measured by high-performance liquid chromatography(HPLC). The survival rate after recurrence was higher in the local recurrence group(n=11)than in the distant metastases group(n=26). The mean Trp/Kyn ratio was lower in the distant metastases group than in the local recurrence group. The mean Trp/Kyn ratio was also lower in patients who had multiple metastases than in patients who had a single metastatic lesion. The Trp/Kyn ratio decreased during chemotherapy in all patients who received chemotherapy.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Tetsuyo
authors.initials: T
authors.lastname: Maeda
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hirano
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D007737:Kynurenine / Q000097:blood; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000201:enzymology*; D014364:Tryptophan / Q000097:blood
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan