title: Complications of intra-arterial chemotherapy for retinoblastoma.
abstract: BACKGROUND
  The purpose of this paper is to perform a systematic review of the published literature on complications of intra-arterial chemothrapy (IAC) for the treatment of retinoblastoma.
  
  
  METHODS
  A literature search was performed using the Pubmed database using the terms. Complications were divided into extraocular and intraocular.
  
  
  RESULTS
  A total of 117 articles were found using this Pubmed search method; 35 articles were selected for review as they describe specifical complications of IAC for retinoblastoma. A variety of extraocular and intraocular complications were reported and discussed.
  
  
  CONCLUSIONS
  IAC for the treatment of retinoblastoma is a technique that has been gaining popularity in recent years, but is not without complications. Continued research is warranted to further improve current techniques and delivery of chemotherapeutic agents into the eye.
authors.affiliation: Children's Hospital , Boston, Massachusetts , USA.
authors.forename: Jose Efren Gonzalez
authors.initials: JE
authors.lastname: Monroy
authors.forename: Darren B
authors.initials: DB
authors.lastname: Orbach
authors.forename: Deborah
authors.initials: D
authors.lastname: VanderVeen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D009880:Ophthalmic Artery; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents
keywords: Chemosurgery; chemotherapy; intra-arterial; melphalan; retinoblastoma; topotecan