title: Hemopoietic effect of extracts from constituent herbal medicines of Samul-tang on phenylhydrazine-induced hemolytic anemia in rats.
abstract: Samul-tang (Si-Wu-Tang, SMT), a kind of herbal medicines, has been used for the hemato-deficient disease for hundreds of years. In this work, investigate the anti-anemia activity of the H2O extracts from constituent herbal medicines of Samul-tang in an anemia model induced by intravenous infection of phenylhydrazine-HCL (PHZ) at 10 mg/kg for 4 days. After PHZ injection, female Sparague-Dawley rats were administrated extracts from constituent herbal medicines of SMT (300 mg/kg/day, p.o.) daily for 1 week. Results showed that sever hemolysis was induced by PHZ. For Paeonia lactiflora (PL2) H2O extract treated groups, the concentration of hemoglobin, hematocrit and red blood cells number increased much more significantly than PHZ-treated group. Moreover, Angelica gigas (AG), Angelica. acutiloba (AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) extract administration significantly improved serum erythropoietin concentration. The activity of aminolevulinic acid dehydrates (ALDL) in liver homegenate was increased in Angelica gigas(AA), Paeonia lactiflora (PL2) and Rehmannia glutinosa (RG) treated group.
authors.affiliation: Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine Republic of Korea.
authors.forename: Hye Won
authors.initials: HW
authors.lastname: Lee
authors.affiliation: Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine Republic of Korea.
authors.forename: Hyojun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine Republic of Korea.
authors.forename: Jin Ah
authors.initials: JA
authors.lastname: Ryuk
authors.affiliation: College of Oriental Medicine, Joongbu University Republic of Korea.
authors.forename: Ki-Jung
authors.initials: KJ
authors.lastname: Kil
authors.affiliation: Korean Medicine Based Herbal Drug Development Group, Herbal Medicine Research Division, Korea Institute of Oriental Medicine Republic of Korea.
authors.forename: Byoung Seob
authors.initials: BS
authors.lastname: Ko
mesh_terms: D000743:Anemia, Hemolytic / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006397:Hematinics / Q000494:pharmacology*; D006400:Hematocrit; D006410:Hematopoiesis / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D010659:Phenylhydrazines; D008517:Phytotherapy; D010946:Plants, Medicinal; D000623:Porphobilinogen Synthase / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D006397:Hematinics; D006454:Hemoglobins; D010659:Phenylhydrazines; C431789:samultang; C030299:phenylhydrazine; D004921:Erythropoietin; D000623:Porphobilinogen Synthase
keywords: SMT); Samul-tang (Si-Wu-Tang; anemia; hematocrit; hemoglobin; herbal medicine; phenylhydrazine-HCL (PHZ)