title: Female specific association between NNMT gene and schizophrenia in a Han Chinese population.
abstract: Accumulating evidence has shown that alterations in one carbon metabolism might play an important role in the pathogenesis of schizophrenia (SZ). Nicotinamide-N-methyltransferase (NNMT) is one of the key enzymes of one-carbon metabolism. To examine whether NNMT gene was associated with SZ in Han Chinese population, we selected seven single nucleotide polymorphisms (SNPs) in NNMT gene, and investigated its association with SZ from a cohort of 42 SZ patients and 86 healthy controls by Mass-ARRAY technology. Statistical analyses revealed that one (rs694539) of the SNPs in the female subgroup showed significant difference between SZ patients and controls both in genotypic (p= 0.0170) and allelic frequencies (p = 0.0059). We also found that the frequency of haplotype 'A G G C T C T' in the female patients was significantly higher than in controls (p=0.0015). Our results suggest that NNMT rs694539 may have a role in the etiology of SZ in a Han Chinese female population.
authors.affiliation: 1. Center for DNA Typing, the Fourth Military Medical University, Xi'an, 710032, China ; 2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Guo-xia
authors.initials: GX
authors.lastname: Wang
authors.affiliation: 3. Department of Anatomy, Histology and Embryology, K. K. Leung Brain Research Centre, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 4. Department of Clinical Laboratory, the Third Affiliated Hospital, Xinxiang Medical University, Xinxiang, 453003, China.
authors.forename: Zhuang-wei
authors.initials: ZW
authors.lastname: Lv
authors.affiliation: 1. Center for DNA Typing, the Fourth Military Medical University, Xi'an, 710032, China ; 2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Mao
authors.initials: M
authors.lastname: Sun
authors.affiliation: 1. Center for DNA Typing, the Fourth Military Medical University, Xi'an, 710032, China ; 2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wu
authors.affiliation: 1. Center for DNA Typing, the Fourth Military Medical University, Xi'an, 710032, China ; 2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Xin-yu
authors.initials: XY
authors.lastname: Chen
authors.affiliation: 1. Center for DNA Typing, the Fourth Military Medical University, Xi'an, 710032, China ; 2. Department of Biochemistry and Molecular Biology, the Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Yuan-ming
authors.initials: YM
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D050903:Nicotinamide N-Methyltransferase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: C494406:NNMT protein, human; D050903:Nicotinamide N-Methyltransferase
keywords: Schizophrenia (SZ); nicotinamide-N-methyltransferase(NNMT); polymorphisms; rs694539.