title: Stem cell therapy for treatment of epilepsy.
abstract: Epilepsy as one of the most common neurological disorders affects more than 50 million people worldwide with a higher prevalence rate in low-income countries. Excessive electrical discharges in neurons following neural cell damage or loss cause recurrent seizures. One of the most common and difficult to treat types of epilepsy is temporal lobe epilepsy (TLE) which results from hippocampal sclerosis. Nowadays, similar to other diseases, epilepsy also is a candidate for treatment with different types of stem cells. Various stem cell types were used for treatment of epilepsy in basic and experimental researches. Two major roles of stem cell therapy in epilepsy are prophylaxis against chronic epilepsy and amelioration cognitive function after the occurrence of TLE. Several animal studies have supported the use of these cells for treating drug-resistant TLE. Although stem cell therapy seems like a promising approach for treatment of epilepsy in the future however, there are some serious safety and ethical concerns that are needed to be eliminated before clinical application.
authors.affiliation: Brain and Spinal Cord Injury Research Center, Cellule Fanavaran Knowledge-Based Organization, Tehran University of Medical Sciences, Tehran, Iran. pr_goodarzi@yahoo.com.
authors.forename: Parisa
authors.initials: P
authors.lastname: Goodarzi
authors.affiliation: Brain and Spinal Cord Injury Research Center, Cellule Fanavaran Knowledge-Based Organization, Tehran University of Medical Sciences, Tehran, Iran. AND Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. hr.aghayan@gmail.com.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Aghayan
authors.affiliation: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Hematology, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran. soleimani.masoud@gmail.com.
authors.forename: Masoud
authors.initials: M
authors.lastname: Soleimani
authors.affiliation: Brain and Spinal Cord Injury Research Center, Cellule Fanavaran Knowledge-Based Organization, Tehran University of Medical Sciences, Tehran, Iran. norouziaj@yahoo.com.
authors.forename: Abbas
authors.initials: A
authors.lastname: Norouzi-Javidan
authors.affiliation: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. fereshteh.jahani@yahoo.com.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Mohamadi-Jahani
authors.affiliation: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. shararehjahangiri@yahoo.com.
authors.forename: Sharareh
authors.initials: S
authors.lastname: Jahangiri
authors.affiliation: Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. emamiraz@tums.ac.ir.
authors.forename: Seyed Hasan
authors.initials: SH
authors.lastname: Emami-Razavi
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Medical Ethics and History of Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. larijanib@tums.ac.ir.
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.affiliation: Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. AND Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. b_arjmand@farabi.tums.ac.ir.
authors.forename: Babak
authors.initials: B
authors.lastname: Arjmand
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000503:physiopathology / Q000628:therapy*; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology / Q000628:therapy*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D009474:Neurons / Q000473:pathology; D033581:Stem Cell Transplantation / Q000379:methods*