title: A catalytic approach to the metal-free reaction of epoxides with ketene silyl acetals for accessing γ-lactones.
abstract: The first catalytic approach to the nucleophilic addition of silyl ketene acetals 2 to epoxides 1 is reported. The defined protocol is metal-free using tetrabutylammonioum fluoride as the catalyst. It works in a very efficient manner under solvent-free conditions (SolFC) allowing γ-lactones 3 to be directly obtained with high regioselectivities and yields.
authors.affiliation: Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Biologia e Biotecnologie, Università di Perugia Via Elce di Sotto, 8, 06123 Perugia, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Bonollo
authors.forename: Amanollah Zarei
authors.initials: AZ
authors.lastname: Ahmady
authors.forename: Chiara
authors.initials: C
authors.lastname: Petrucci
authors.forename: Assunta
authors.initials: A
authors.lastname: Marrocchi
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Pizzo
authors.forename: Luigi
authors.initials: L
authors.lastname: Vaccaro
mesh_terms: D000080:Acetals / Q000737:chemistry*; D064751:Ammonium Compounds / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000737:chemistry*
chemical_list: D000080:Acetals; D064751:Ammonium Compounds; D004852:Epoxy Compounds; D007783:Lactones; D008670:Metals; D017646:Organosilicon Compounds