title: Carbohydrates as a reagent in multicomponent reactions: one-pot access to a new library of hydrophilic substituted pyrimidine-fused heterocycles.
abstract: In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also, the three-component condensation reaction between D-glucosamine, aldehyde, and barbituric acid efficiently provided polyhydroxy substituted PFH derivatives in a one-pot reaction under mild and green conditions. These new one-pot reactions gave a range of polyhydroxy substituted PFHs in good to excellent yield.
authors.affiliation: Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran. khalafi@chem.susc.ac.ir panahi@shirazu.ac.ir.
authors.forename: Maryam
authors.initials: M
authors.lastname: Nourisefat
authors.forename: Farhad
authors.initials: F
authors.lastname: Panahi
authors.forename: Ali
authors.initials: A
authors.lastname: Khalafi-Nezhad