title: Additional linear ablation from the superior vena cava to right atrial septum after pulmonary vein isolation improves the clinical outcome in patients with paroxysmal atrial fibrillation: prospective randomized study.
abstract: OBJECTIVE
  Although circumferential pulmonary vein isolation (CPVI) has been considered as the cornerstone for paroxysmal atrial fibrillation (PAF) ablation, there has been a substantial recurrence rate. We conducted a prospectively randomized study to evaluate whether additional linear ablation from the superior vena cava (SVC) to the right atrial (RA) septum (SVC-L) improves the clinical outcome.
  
  
  RESULTS
  This study enroled 200 patients with PAF (male 74.5%, 56.8 ± 11.7 years old) randomly assigned to either the CPVI (n = 100) or CPVI + SVC-L (n = 100) groups. An RA isthmus ablation was performed in all patients. The CPVI + SVC-L group required a longer ablation procedure time (82.7 ± 17.9 min) than the CPVI group (63.6 ± 16.8 min, P < 0.001). The complication rates were 5% in CPVI + SVC-L group and 2% in CPVI group, respectively (P = 0.445). Two CPVI + SVC-L group patients had post-procedural sinus node dysfunction, which recovered within 24 h. During 12.2 ± 5.3 months of follow-up, the recurrence rate was significantly lower in the CPVI + SVC-L group (6%) than the CPVI group (27%, P < 0.001). The post-procedural 3-month follow-up heart rate variability in the CPVI + SVC-L group showed a significantly greater reduction in the rMSSD (25.2 ± 13.7 vs. 13.7 ± 8.5 ms, P < 0.001), HF (10.2 ± 7.1 vs. 5.5 ± 5.8 ms(2), P < 0.001), and LF/HF (1.6 ± 0.5 vs. 0.9 ± 0.3, P < 0.001) than in the CPVI group.
  
  
  CONCLUSIONS
  In spite of a longer procedure time and risk of transient sinus node dysfunction, an SVC-L in addition to CPVI improved the clinical outcome of catheter ablation, and was associated with post-procedural autonomic neural remodelling in patients with PAF.
authors.affiliation: Division of Cardiology, Eulji University Hospital, Daejeon 302-799, Republic of Korea.
authors.forename: Ki-Woon
authors.initials: KW
authors.lastname: Kang
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea hnpak@yuhs.at chunhwang17@gmail.com.
authors.forename: Hui-Nam
authors.initials: HN
authors.lastname: Pak
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea.
authors.forename: Junbeom
authors.initials: J
authors.lastname: Park
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea.
authors.forename: Jin Gyu
authors.initials: JG
authors.lastname: Park
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea.
authors.forename: Jae Sun
authors.initials: JS
authors.lastname: Uhm
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea.
authors.forename: Boyoung
authors.initials: B
authors.lastname: Joung
authors.affiliation: Division of Cardiology, Yonsei University Health System, 50 Yonsei-roSeodaemungu, Seoul 120-752, Republic of Korea.
authors.forename: Moon-Hyoung
authors.initials: MH
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Utah Valley Medical Center, 1055 North 500 West, Provo, UT 84604, USA hnpak@yuhs.at chunhwang17@gmail.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Hwang
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000601:surgery*; D054087:Atrial Septum / Q000601:surgery*; D018780:Body Surface Potential Mapping; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006329:Heart Conduction System / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011667:Pulmonary Veins / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome; D014683:Vena Cava, Superior / Q000601:surgery*
keywords: Catheter ablation; Paroxysmal atrial fibrillation; Recurrence; Superior vena cava