title: [Patterns and risk factors of recurrence in triple-negative breast cancer].
abstract: OBJECTIVE
  To analyze the recurrence characteristics of triple-negative breast cancer (TNBC) and explore their clinicopathological correlations in northern China.
  
  
  METHODS
  Regression analyses were performed for 4 579 breast cancer patients from September 2002 to September 2007. Among them, there were 787 TNBC patients.
  
  
  RESULTS
  The median follow-up period was 72 (9-116) months. And 187 (23.8%) TNBC patients recurred and it was significantly different from the recurrence rate of non-TNBC group (17.4%, P = 0.024). The median time to recurrence was 30.2 (4-110) months and 36.3% recurred 2 years while 27.8% did within 2-3 years. The rates of lung, liver and brain metastases to other sites were higher in TNBC patients than those in non-TNBC patients. TNBC patients had higher local recurrence rates than non-TNBC counterparts (2.92% vs 1.56%) (P = 0.009). Age, regional lymph node infiltration, tumor size and pathological stage were all independent prognostic factors of TNBC.
  
  
  CONCLUSIONS
  TNBC has unique recurrence characteristics. It is prone to recur shortly with a high local recurrence rate. Metastatic rate is higher in visceral organ than bone.
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
authors.forename: Xiaobei
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Third Department of Breast Cancer, China Tianjin Breast Cancer Prevention, Treatment research center, Tianjin Medical University Cancer Institute and Hospital; Key laboratory of Breast Cancer Prevention & therapy under Ministry of Education; Key Laboratory of Cancer Prevention & Therapy, Tianjin 300060, China. Email: zhangjin@tjmuch.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
mesh_terms: D002681:China; D006801:Humans; D008198:Lymph Nodes; D009367:Neoplasm Staging; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D064726:Triple Negative Breast Neoplasms / Q000175:diagnosis*