title: Reconstruction of multiple myeloma lesions around the pelvis and acetabulum.
abstract: Multiple myeloma is a malignancy of monoclonal plasma cells (plasma cells are of B-lymphocyte lineage of the hematopoietic system). It is the second most prevalent blood malignancy after non-Hodgkin's lymphoma. It accounts for approximately 1 % of all malignancies and 2 % of all cancer deaths. Bony involvement is very common; the incidence of pelvic and periacetabular involvement in MM is reported to be around 6 %. Lytic lesions comprise a hallmark of multiple myeloma, which may be complicated with pathologic fractures in a substantial percentage of patients. Pelvic and periacetabular bony involvement of multiple myeloma is associated with some unique characteristics regarding the biomechanics of this specific anatomical region, the morbidity, the overall survival, and prognosis, which all reflect to impairment of quality of life. In this paper, we review the special features of multiple myeloma lesions around the pelvis and acetabulum and present an algorithm of management with the use of current surgical techniques.
authors.affiliation: 1st Department of Orthopaedic Surgery, ATTIKON University General Hospital, University of Athens, 1 Rimini Street, 12462, Chaidari, Greece, bsakellariou@gmail.com.
authors.forename: Vasileios I
authors.initials: VI
authors.lastname: Sakellariou
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: Olga
authors.initials: O
authors.lastname: Savvidou
authors.forename: Franklin H
authors.initials: FH
authors.lastname: Sim
authors.forename: Panayiotis J
authors.initials: PJ
authors.lastname: Papagelopoulos
mesh_terms: D000077:Acetabulum / Q000601:surgery*; D019644:Arthroplasty, Replacement, Hip; D001858:Bone Nails; D001859:Bone Neoplasms / Q000175:diagnosis / Q000601:surgery*; D001862:Bone Resorption / Q000175:diagnosis / Q000601:surgery; D001864:Bone Wires; D000075202:Contraindications; D005598:Fractures, Spontaneous / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis / Q000601:surgery*; D020360:Neoadjuvant Therapy / Q000379:methods; D010347:Patient Care Planning; D010384:Pelvic Bones / Q000601:surgery*; D011300:Preoperative Care / Q000379:methods; D013526:Surgical Mesh