title: Total analysis systems with Thermochromic Etching Discs technology.
abstract: A new analytical system based on Thermochromic Etching Discs (TED) technology is presented. TED comprises a number of attractive features such as track independency, selective irradiation, a high power laser, and the capability to create useful assay platforms. The analytical versatility of this tool opens up a wide range of possibilities to design new compact disc-based total analysis systems applicable in chemistry and life sciences. In this paper, TED analytical implementation is described and discussed, and their analytical potential is supported by several applications. Microarray immunoassay, immunofiltration assay, solution measurement, and cell culture approaches are herein addressed in order to demonstrate the practical capacity of this system. The analytical usefulness of TED technology is herein demonstrated, describing how to exploit this tool for developing truly integrated analytical systems that provide solutions within the point of care framework.
authors.affiliation: IDM, Departamento de Química, Universitat Politècnica de València , Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Miquel
authors.initials: M
authors.lastname: Avella-Oliver
authors.forename: Sergi
authors.initials: S
authors.lastname: Morais
authors.forename: Javier
authors.initials: J
authors.lastname: Carrascosa
authors.forename: Rosa
authors.initials: R
authors.lastname: Puchades
authors.forename: Ángel
authors.initials: Á
authors.lastname: Maquieira
mesh_terms: D001681:Biological Assay / Q000295:instrumentation*; D015374:Biosensing Techniques; D002478:Cells, Cultured; D002623:Chemistry Techniques, Analytical / Q000295:instrumentation* / Q000379:methods*; D006801:Humans; D046228:Microarray Analysis; D013696:Temperature