title: Evaluation of platelet distribution width and mean platelet volume in patients with carotid artery stenosis.
abstract: Platelets contribute to the pathogenesis of atherosclerosis. Platelet activation has been linked with increased mean platelet volume (MPV) and platelet distribution width (PDW). We investigated the association between PDW, MPW, and the degree of carotid artery stenosis (CS). Patients (n = 229) were divided into 3 groups according to the North American Symptomatic Carotid Endarterectomy Trial criteria. Demographic and clinical features were collected retrospectively. Correlation analysis showed a positive association between PDW and the degree of CS. However, there was no significant correlation between CS and MPV. Moreover, we observed that PDW and low-density lipoprotein cholesterol were independent predictors of the degree of CS. This study showed that PDW, not MPV, is related to the degree of CS. Platelet distribution width could be a useful biomarker for CS. Whether targeting PDW will be of clinical benefit remains to be established.
authors.affiliation: Department of Radiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey gurhanadam@hotmail.com.
authors.forename: Gürhan
authors.initials: G
authors.lastname: Adam
authors.affiliation: Department of Internal medicine, Çanakkale State Hospital, Çanakkale, Turkey.
authors.forename: Erdem
authors.initials: E
authors.lastname: Kocak
authors.affiliation: Department of Neurology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Adile
authors.initials: A
authors.lastname: Özkan
authors.affiliation: Department of Radiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Reşorlu
authors.affiliation: Department of Radiology, Ege University, Izmir, Turkey.
authors.forename: Celal
authors.initials: C
authors.lastname: Çınar
authors.affiliation: Department of Radiology, Ege University, Izmir, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Bozkaya
authors.affiliation: Department of Cardiovascular Surgery, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Kurt
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.affiliation: Department of Neurology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Halil Murat
authors.initials: HM
authors.lastname: Şen
authors.affiliation: Department of Physical Medicine and Rehabilitation, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Ayla
authors.initials: A
authors.lastname: Akbal
authors.affiliation: Department of Internal Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Neslihan
authors.initials: N
authors.lastname: Bozkurt
authors.affiliation: Department of Cardiovascular Surgery, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Saçar
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000473:pathology*; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging; D048429:Cell Size; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D015539:Platelet Activation; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
keywords: carotid artery stenosis; mean platelet volume; platelet distribution width