title: [Effect of alpha4beta2 nicotinic acetylcholine receptor agonists and antagonists on learning in female rats during different phases of ovary cycle].
abstract: The present work was devoted to the comparative analysis of alpha4beta2 nicotinic acetylcholine receptors (nAChRs) in learning/ memory processes during ovary cycle assessed in adult female rats. RJR-2403 (1.0 mg/kg, i.p.), alpha4beta2 nAChRs agonist and mecamylamine (1.0 mg/kg, i.p.), alpha4beta2 nAChRs antagonist were injected chronically during 14 days. The processes of learning/memory were assessed in different models of learning: passive avoidance performance and Morris water maze. Chronic RJR-2403 administration to female rats improved the passive avoidance performance in proestrous and estrous as compared to the control animals. Also, RJR-2403 restored spatial learning during proestrous phases in Morris water maze, and stimulated the dynamics of spatial learning during estrous phases. On the contrary, chronic mecamylamine administration impaired non-spatial, and especially, spatial learning in females during key phases of ovary cycle. The results of the study suggest positive effect of alpha4beta2 nAChRs stimulation in learning/ memory processes during ovary cycle in the adult female rats.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
authors.forename: H O
authors.initials: HO
authors.lastname: Frolova
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D030762:Estrous Cycle / Q000378:metabolism*; D005260:Female; D007858:Learning / Q000187:drug effects*; D018782:Maze Learning / Q000187:drug effects; D008464:Mecamylamine / Q000494:pharmacology; D009538:Nicotine / Q000031:analogs & derivatives / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000494:pharmacology*; D018733:Nicotinic Antagonists / Q000494:pharmacology*; D021122:Protein Subunits; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D021122:Protein Subunits; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; C012419:metanicotine; D008464:Mecamylamine; D009538:Nicotine