title: Decision-making impairments in Parkinson's disease as a by-product of defective cost-benefit analysis and feedback processing.
abstract: Studies examining decision-making in people with Parkinson's disease (PD) show impaired performance on a variety of tasks. However, there are also demonstrations that patients with PD can make optimal decisions just like healthy age-matched controls. We propose that the reason for these mixed findings is that PD does not produce a generalized impairment of decision-making, but rather affects sub-components of this process. In this review we evaluate this hypothesis by considering the empirical evidence examining decision-making in PD. We suggest that of the various stages of the decision-making process, the most affected in PD are (1) the cost-benefit analysis stage and (2) the outcome evaluation stage. We consider the implications of this proposal for research in this area.
authors.affiliation: Biological & Experimental Psychology Group, School of Biological & Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
authors.forename: Agata
authors.initials: A
authors.lastname: Ryterska
authors.forename: Marjan
authors.initials: M
authors.lastname: Jahanshahi
authors.forename: Magda
authors.initials: M
authors.lastname: Osman
mesh_terms: D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D003657:Decision Making / Q000502:physiology*; D030141:Feedback, Psychological; D006801:Humans; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications / Q000503:physiopathology*; D012309:Risk-Taking
keywords: Parkinson's disease; cost–benefit analysis; decision-making; feedback; valuation