title: Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins.
abstract: Pathogen-induced reorganization of the host cell cytoskeleton is a common strategy utilized in host cell invasion by many facultative intracellular bacteria, such as Shigella, Listeria, enteroinvasive E. coli and Salmonella. Shigella is an enteroinvasive intracellular pathogen that preferentially infects human epithelial cells and causes bacillary dysentery. Invasion of Shigella into intestinal epithelial cells requires extensive remodeling of the actin cytoskeleton with the aid of pathogenic effector proteins injected into the host cell by the activity of the type III secretion system. These so-called Shigella invasins, including IpaA, IpaC, IpgB1, IpgB2 and IpgD, modulate the actin-regulatory system in a concerted manner to guarantee efficient entry of the bacteria into host cells.
authors.affiliation: Division of Polar Life Sciences, Korea Polar Research Institute, Incheon 406-840, Korea. junhyucklee@kopri.re.kr.
authors.forename: Jun Hyuck
authors.initials: JH
authors.lastname: Lee
authors.affiliation: The Scripps Research Institute, Scripps Florida, 130 Scripps Way, Jupiter, FL 33458, USA. hajpark@scripps.edu.
authors.forename: HaJeung
authors.initials: H
authors.lastname: Park
authors.affiliation: Laboratory of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. yhp@snu.ac.kr.
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Park
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis / Q000378:metabolism; D001426:Bacterial Proteins / Q000032:analysis / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology*; D004405:Dysentery, Bacillary / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D012760:Shigella / Q000502:physiology*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins