title: Lmo0171, a novel internalin-like protein, determines cell morphology of Listeria monocytogenes and its ability to invade human cell lines.
abstract: Internalins comprise a class of Listeria monocytogenes proteins responsible for activation of signalling pathways leading to phagocytic uptake of the bacterium by the host cell. In this paper, a possible role of Lmo0171-a new member of the internalin family was investigated. Disruption of the lmo0171 gene resulted in important cell morphology alterations along with a decrease in the ability to invade three eukaryotic cell lines, that is Int407, Hep-2 and HeLa and diminished adhesion efficiency to int407, thereby suggesting bifunctionality of the newly characterised Lmo0171 internalin.
authors.affiliation: Department of Applied Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland, radeks@biol.uw.edu.pl.
authors.forename: Radosław
authors.initials: R
authors.lastname: Stachowiak
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jagielski
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Roeske
authors.forename: Olga
authors.initials: O
authors.lastname: Osińska
authors.forename: Paweł
authors.initials: P
authors.lastname: Gunerka
authors.forename: Jarosław
authors.initials: J
authors.lastname: Wiśniewski
authors.forename: Jacek
authors.initials: J
authors.lastname: Bielecki
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D002460:Cell Line; D023061:Gene Order; D006367:HeLa Cells; D006801:Humans; D008089:Listeria monocytogenes / Q000235:genetics* / Q000472:pathogenicity; D016296:Mutagenesis; D009154:Mutation; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; C069761:internalin protein, Bacteria