title: Diagnosis and staging of superficial esophageal precursor based on pre-endoscopic resection system comparable to endoscopic resection.
abstract: BACKGROUND
  Endoscopic treatments for early esophageal squamous cell carcinoma and the esophageal neoplasm are two types: endoscopic resection (ER) and ablation. Resection enables evaluation of the lesion in the ER specimens, while ablation cannot. We sought to establish a pre-ER evaluated system with a diagnostic and staging accuracy similar to ER for the development of ablation therapy.
  
  
  METHODS
  In our study, we collected data pertaining to early esophageal cancer and esophageal neoplasm treated with ER, analyzed the pre- and post-ER data of the lesions and evaluated the diagnostic accuracy of pre-ER system compared with the gold standard.
  
  
  RESULTS
  The diagnostic accuracy rate was 91% based on the pre-ER system compared with the gold standard, and 93% based on the ER diagnosis. The AUC of the pre-ER system was 0.964, while the ER examination was 0.971.
  
  
  CONCLUSIONS
  These results suggest that the accuracy of pre-ER system was comparable to ER. The pre-ER system enables prediction of histological diagnosis and stage of the lesions, and the choice of treatment for superficial esophageal neoplasm.
authors.forename: Xiumin
authors.initials: X
authors.lastname: Qin
authors.forename: Shun
authors.initials: S
authors.lastname: He
authors.forename: Yueming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Liyan
authors.initials: L
authors.lastname: Xue
authors.forename: Ning
authors.initials: N
authors.lastname: Lu
authors.affiliation: Department of Endoscopy, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. wangguiq@126.com.
authors.forename: Guiqi
authors.initials: G
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D020701:Esophagoscopes; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012372:ROC Curve; D012189:Retrospective Studies