title: Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison.
abstract: The angiotensin type 2 receptor (AT2R) and the receptor Mas are components of the protective arms of the renin-angiotensin system (RAS), i.e. they both mediate tissue protective and regenerative actions. The spectrum of actions of these two receptors and their signalling mechanisms display striking similarities. Moreover, in some instances, antagonists for one receptor are able to inhibit the action of agonists for the respective other receptor. These observations suggest that there may be a functional or even physical interaction of both receptors. This article discusses potential mechanisms underlying the phenomenon of blockade of angiotensin-(1-7) [Ang-(1-7)] actions by AT2R antagonists and vice versa. Such mechanisms may comprise dimerization of the receptors or dimerization-independent mechanisms such as lack of specificity of the receptor ligands used in the experiments or involvement of the Ang-(1-7) metabolite alamandine and its receptor MrgD in the observed effects. We conclude that evidence for a functional interaction of both receptors is strong, but that such an interaction may be species- and/or tissue-specific and that elucidation of the precise nature of the interaction is only at the very beginning.
authors.forename: Daniel
authors.initials: D
authors.lastname: Villela
authors.affiliation: †Center for Cardiovascular Research, Institute of Pharmacology, Charité-Medical Faculty Berlin, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Leonhardt
authors.affiliation: ‡Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, U.S.A.
authors.forename: Neal
authors.initials: N
authors.lastname: Patel
authors.affiliation: ‡Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, U.S.A.
authors.forename: Jason
authors.initials: J
authors.lastname: Joseph
authors.affiliation: †Center for Cardiovascular Research, Institute of Pharmacology, Charité-Medical Faculty Berlin, Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kirsch
authors.affiliation: §Department of Medicinal Chemistry, University of Uppsala, Uppsala, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Hallberg
authors.affiliation: ∥CARIM, Maastricht University, Maastricht, The Netherlands.
authors.forename: Thomas
authors.initials: T
authors.lastname: Unger
authors.affiliation: ¶Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Bader
authors.affiliation: *Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
authors.forename: Robson A
authors.initials: RA
authors.lastname: Santos
authors.affiliation: ‡Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL, U.S.A.
authors.forename: Colin
authors.initials: C
authors.lastname: Sumners
authors.forename: U Muscha
authors.initials: UM
authors.lastname: Steckelings
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D011485:Protein Binding; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D044139:Receptor, Angiotensin, Type 2 / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D008024:Ligands; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D044139:Receptor, Angiotensin, Type 2; D043562:Receptors, G-Protein-Coupled