title: Preventive effect of intraoperative landiolol administration on atrial fibrillation after off-pump coronary artery bypass grafting.
abstract: BACKGROUND
  Postoperative atrial fibrillation (AF) is a common complication of cardiac surgery that is associated with an increased incidence of other complications. This study evaluated the safety and efficacy of landiolol hydrochloride--an ultrashort-acting β1-selective blocker and highly regulated drug, positioned as a class 1 antiarrhythmic in Japan guidelines--for the prevention of AF after off-pump coronary artery bypass grafting (CABG).
  
  
  METHODS
  Between January 2011 and November 2013, 116 patients underwent CABG at Fukuoka University Hospital. They were divided into two groups: group L consisted of patients who were administered landiolol hydrochloride at 2 μg/kg/min after completion of all distal anastomoses; group C was the control group consisting of patients who were not administered landiolol. Patient backgrounds, intraoperative variables and incidence of postoperative complications were compared.
  
  
  RESULTS
  No significant between-group differences were observed in patient backgrounds or incidence of complications other than postoperative AF, which occurred significantly less frequently in group L. After administration of landiolol, heart rate decreased but no change was observed in arterial pressure or other parameters, and patient hemodynamics remained stable.
  
  
  CONCLUSIONS
  Intraoperative and perioperative administration of low-dose landiolol has a preventive effect on the development of AF after CABG surgery.
authors.affiliation: Department of Cardiovascular Surgery, Fukuoka University Faculty of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0133, Japan, mosumi@fukuoka-u.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Osumi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tashiro
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Morita
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamiya
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Minematsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Nishimi
authors.forename: Hideichi
authors.initials: H
authors.lastname: Wada
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects* / Q000379:methods; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D015994:Incidence; D007430:Intraoperative Care / Q000379:methods; D007564:Japan / Q000453:epidemiology; D008297:Male; D009025:Morpholines / Q000008:administration & dosage / Q000009:adverse effects; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014508:Urea / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000889:Anti-Arrhythmia Agents; D009025:Morpholines; C077049:landiolol; D014508:Urea