title: Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection.
abstract: BACKGROUND
  Daptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.
  
  
  METHODS
  Case reports and review of the literature.
  
  
  RESULTS
  The first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.
  
  
  CONCLUSIONS
  Daptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.
authors.affiliation: 1 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital , Lausanne, Switzerland .
authors.forename: Erlangga
authors.initials: E
authors.lastname: Yusuf
authors.forename: Nancy
authors.initials: N
authors.lastname: Perrottet
authors.forename: Christina
authors.initials: C
authors.lastname: Orasch
authors.forename: Olivier
authors.initials: O
authors.lastname: Borens
authors.forename: Andrej
authors.initials: A
authors.lastname: Trampuz
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D017576:Daptomycin / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology*; D013902:Radiography, Thoracic; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013212:Staphylococcus epidermidis / Q000302:isolation & purification; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin