title: Relationship among tobacco habits, human papilloma virus (HPV) infection, p53 polymorphism/mutation and the risk of oral squamous cell carcinoma.
abstract: The prevalence of oral squamous cell carcinoma (OSCC) has significantly increased over decades in several countries and human papilloma virus (HPV) has been indicated as one of the underlying causes. This suggests that HPV plays a role in the early stages of carcinogenesis but is not a requisite for the maintenance and progression of malignant state. p53 is a tumor suppressor gene that checks the cell and promotes apoptosis and cell repair that can be deactivated by mutations and a viral interaction leading to cancer and individuals with particular polymorphic variant of p53 is more susceptible to HPV-induced carcinogenesis. The present study has been carried out to detect and correlate p53 polymorphism/mutation, HPV DNA in the biopsy samples of oral cancer patients who had tobacco habits.
authors.affiliation: Department of Oral Pathology, Burdwan Dental College, Burdwan, India.
authors.forename: Bidyut
authors.initials: B
authors.lastname: Chakrobarty
authors.affiliation: Department of Oral Pathology, Dr. R. Ahmed Dental College, Kolkata, West Bengal, India.
authors.forename: Jay Gopal
authors.initials: JG
authors.lastname: Roy
authors.affiliation: Department of Oral Pathology, Gandhi Institute of Technology and Management Dental College, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Sumit
authors.initials: S
authors.lastname: Majumdar
authors.affiliation: Department of Oral Pathology, Gandhi Institute of Technology and Management Dental College, Visakhapatnam, Andhra Pradesh, India.
authors.forename: Divya
authors.initials: D
authors.lastname: Uppala
keywords: Human papilloma virus; oral squamous cell carcinoma; p53 polymorphism/mutation