title: Plasmonic nanodiamonds: targeted core-shell type nanoparticles for cancer cell thermoablation.
abstract: Targeted biocompatible nanostructures with controlled plasmonic and morphological parameters are promising materials for cancer treatment based on selective thermal ablation of cells. Here, core-shell plasmonic nanodiamonds consisting of a silica-encapsulated diamond nanocrystal coated in a gold shell are designed and synthesized. The architecture of particles is analyzed and confirmed in detail using electron tomography. The particles are biocompatibilized using a PEG polymer terminated with bioorthogonally reactive alkyne groups. Azide-modified transferrin is attached to these particles, and their high colloidal stability and successful targeting to cancer cells overexpressing the transferrin receptor are demonstrated. The particles are nontoxic to the cells and they are readily internalized upon binding to the transferrin receptor. The high plasmonic cross section of the particles in the near-infrared region is utilized to quantitatively ablate the cancer cells with a short, one-minute irradiation by a pulse 750-nm laser.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, v.v.i, Academy of Sciences of the Czech Republic, Flemingovo nam. 2, 166 10, Prague 6, Czech Republic.
authors.forename: Ivan
authors.initials: I
authors.lastname: Rehor
authors.forename: Karin L
authors.initials: KL
authors.lastname: Lee
authors.forename: Kevin
authors.initials: K
authors.lastname: Chen
authors.forename: Miroslav
authors.initials: M
authors.lastname: Hajek
authors.forename: Jan
authors.initials: J
authors.lastname: Havlik
authors.forename: Jana
authors.initials: J
authors.lastname: Lokajova
authors.forename: Milan
authors.initials: M
authors.lastname: Masat
authors.forename: Jitka
authors.initials: J
authors.lastname: Slegerova
authors.forename: Sourabh
authors.initials: S
authors.lastname: Shukla
authors.forename: Hamed
authors.initials: H
authors.lastname: Heidari
authors.forename: Sara
authors.initials: S
authors.lastname: Bals
authors.forename: Nicole F
authors.initials: NF
authors.lastname: Steinmetz
authors.forename: Petr
authors.initials: P
authors.lastname: Cigler
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D001672:Biocompatible Materials / Q000493:pharmacokinetics; D002232:Carbocyanines / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D053685:Laser Therapy / Q000379:methods; D058990:Molecular Targeted Therapy / Q000379:methods; D058612:Nanodiamonds / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry; D057145:Nanoshells / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011990:Receptors, Transferrin / Q000378:metabolism; D014168:Transferrin / Q000737:chemistry / Q000494:pharmacology
chemical_list: C569686:Alexa Fluor 647; D001672:Biocompatible Materials; D002232:Carbocyanines; D058612:Nanodiamonds; D011990:Receptors, Transferrin; D014168:Transferrin; D011092:Polyethylene Glycols; D006046:Gold
keywords: ablation; cancer; gold; nanodiamonds; plasmonics