title: Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.
abstract: Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.
authors.affiliation: Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, NJ 08854-8087, USA.
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Ouimet
authors.forename: Renata
authors.initials: R
authors.lastname: Fogaça
authors.forename: Sabrina S
authors.initials: SS
authors.lastname: Snyder
authors.forename: Sameer
authors.initials: S
authors.lastname: Sathaye
authors.forename: Luiz H
authors.initials: LH
authors.lastname: Catalani
authors.forename: Darrin J
authors.initials: DJ
authors.lastname: Pochan
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Uhrich
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D016923:Cell Death / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055119:Elastic Modulus / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006868:Hydrolysis; D007249:Inflammation / Q000188:drug therapy*; D051379:Mice; D011091:Polyesters / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012212:Rheology / Q000187:drug effects; D020156:Salicylic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D044366:Transition Temperature; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000812:Anhydrides; D000893:Anti-Inflammatory Agents; D011091:Polyesters; D014409:Tumor Necrosis Factor-alpha; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011205:Povidone; D020156:Salicylic Acid
keywords: biodegradable; blending; drug delivery system; hydrogel; poly(anhydride-esters)