title: Focal association between wall shear stress and clinical coronary artery disease progression.
abstract: Wall shear stress (WSS) has been investigated as a potential prospective marker to identify rapidly progressing coronary artery disease (CAD) and potential for lesions to acquire vulnerable characteristics. Previous investigations, however, are limited by a lack of understanding of the focal association between WSS and CAD progression (i.e., data are notably spatially averaged). Thus, the aim of this investigation was to examine the focal association between WSS and coronary atherosclerosis progression, and compare these results to those determined by spatial averaging. Five patients with CAD underwent baseline and 6-month follow-up angiographic and virtual histology-intravascular ultrasound imaging to quantify CAD progression. Patient-specific computational fluid dynamics models were constructed to compute baseline WSS values, which were either averaged around the entire artery circumference or examined in focal regions (sectors). Analysis of data within each sector (n = 3871) indicated that circumferentially averaged and sector WSS values were statistically different (p < 0.05) and exhibited poor agreement (concordance correlation coefficient = 0.69). Furthermore, differences were observed between the analysis techniques when examining the association of WSS and CAD progression. This investigation highlights the importance of examining spatially heterogeneous variables at a focal level to reduce the affect of data reduction and warrants implementation in a larger clinical study to determine the predictive power in prospectively identifying rapidly progressing and/or vulnerable coronary plaques.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Drive, Room 2127, Atlanta, GA, 30332, USA, lucas.timmins@bme.gatech.edu.
authors.forename: Lucas H
authors.initials: LH
authors.lastname: Timmins
authors.forename: David S
authors.initials: DS
authors.lastname: Molony
authors.forename: Parham
authors.initials: P
authors.lastname: Eshtehardi
authors.forename: Michael C
authors.initials: MC
authors.lastname: McDaniel
authors.forename: John N
authors.initials: JN
authors.lastname: Oshinski
authors.forename: Habib
authors.initials: H
authors.lastname: Samady
authors.forename: Don P
authors.initials: DP
authors.lastname: Giddens
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D018450:Disease Progression; D006801:Humans; D008955:Models, Cardiovascular; D013314:Stress, Mechanical