title: Cryosupernatant and Immunosuppression as Effective Alternative Therapies for TTP in Three Pediatric SLE Patients.
abstract: Thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE) very rarely present simultaneously and pose a diagnostic and therapeutic dilemma to the physician. Prompt diagnosis and management with plasma exchange and immunosuppression is life-saving. To describe the effectiveness of cryosupernatant and steroids in pediatric SLE with TTP. We describe three children aged 12-14 years with SLE who were diagnosed with TTP based on fever, CNS manifestations, ANA, anti-dsDNA, anti-sm positivity, hypocomplementemia, and microangiopathic anemia with thrombocytopenia. All three children were managed with cryosupernatant and steroids without plasmapheresis. All children improved with cryosupernatant and steroids. All attained remission within 10 days. They were doing well at last follow up without relapse or flare. Cryosupernatant and steroids may be an effective therapy for Thrombotic thrombocytopenic purpura with systemic lupus erythematosus.
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Pragathesh
authors.initials: P
authors.lastname: Palaniappan
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Arul Premanand
authors.initials: AP
authors.lastname: Lionel
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Indira
authors.initials: I
authors.lastname: Agarwal
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Sarah
authors.initials: S
authors.lastname: Mathai
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Leni
authors.initials: L
authors.lastname: Mathew
authors.affiliation: Jaslok Hospital & Research Centre, 15 - Dr. Deshmukh Marg, Pedder Road, Mumbai, 400 026 India.
authors.forename: Sanwar
authors.initials: S
authors.lastname: Agarwal
authors.affiliation: Jaslok Hospital & Research Centre, 15 - Dr. Deshmukh Marg, Pedder Road, Mumbai, 400 026 India.
authors.forename: Purva
authors.initials: P
authors.lastname: Keni
authors.affiliation: Jaslok Hospital & Research Centre, 15 - Dr. Deshmukh Marg, Pedder Road, Mumbai, 400 026 India.
authors.forename: Raju
authors.initials: R
authors.lastname: Khubchandani
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Sathish
authors.initials: S
authors.lastname: Kumar
keywords: Cryosupernatant; Pediatric systemic lupus erythematosus; Thrombotic thrombocytopenic purpura