title: Management of fatigue in persons with multiple sclerosis.
abstract: Fatigue is one of the most common symptoms of multiple sclerosis. Despite advances in pharmacological and non-pharmacological treatment, fatigue continues to be the disabling symptom in persons with MS (pwMS), affecting almost 80% of pwMS. In current practice, both pharmacological and non-pharmacological interventions are used in combination, encompassing a multi-disciplinary approach. The body of research investigating the effect of these interventions is growing. This review systematically evaluated the existing evidence on the effectiveness and safety of different interventions currently applied for the management of fatigue in person with multiple sclerosis in improving patient outcomes, to guide treating clinicians.
authors.affiliation: Department of Rehabilitation Medicine, Royal Melbourne Hospital , Melbourne, VIC , Australia ; The University of Melbourne , Melbourne, VIC , Australia ; School of Public Health and Preventive Medicine, Monash University , Melbourne, VIC , Australia.
authors.forename: Fary
authors.initials: F
authors.lastname: Khan
authors.affiliation: Department of Rehabilitation Medicine, Royal Melbourne Hospital , Melbourne, VIC , Australia.
authors.forename: Bhasker
authors.initials: B
authors.lastname: Amatya
authors.affiliation: Department of Rehabilitation Medicine, Royal Melbourne Hospital , Melbourne, VIC , Australia ; The University of Melbourne , Melbourne, VIC , Australia.
authors.forename: Mary
authors.initials: M
authors.lastname: Galea
keywords: disability; fatigue; multiple sclerosis; rehabilitation outcomes; symptomatic treatment