title: HLA-DRA is associated with Parkinson's disease in Iranian population.
abstract: The rs3129882, a noncoding variant in HLA-DR, was found to be associated with Parkinson's disease (PD) using several genome-wide association studies. The aim of this replication study was to explore the relationship between this variant and PD in Iranian population. Genomic DNA was extracted from peripheral blood samples, and the rs3129882 SNP was genotyped using a PCR-RFLP method in 520 PD patients and 520 healthy Iranian controls. Significant differences were found in allele frequencies between patients and controls (χ(2) = 4.64, P = 0.031). Under additive and dominant models, the association of the SNP with PD risk is significant, where the A allele was observed to be protective. The results suggest that rs3129882 polymorphism may be a risk factor for PD in Iranian. This is the first study reporting such an association in this population. More replication studies are needed to confirm this data.
authors.affiliation: Department of Biochemistry, Fasa University of Medical Sciences, Fasa, Iran.
authors.forename: J
authors.initials: J
authors.lastname: Jamshidi
authors.forename: A
authors.initials: A
authors.lastname: Movafagh
authors.forename: B
authors.initials: B
authors.lastname: Emamalizadeh
authors.forename: A
authors.initials: A
authors.lastname: Zare Bidoki
authors.forename: A
authors.initials: A
authors.lastname: Manafi
authors.forename: S
authors.initials: S
authors.lastname: Ghasemi Firouzabadi
authors.forename: G-A
authors.initials: GA
authors.lastname: Shahidi
authors.forename: S
authors.initials: S
authors.lastname: Kazeminasab
authors.forename: P
authors.initials: P
authors.lastname: Petramfar
authors.forename: A
authors.initials: A
authors.lastname: Fazeli
authors.forename: M
authors.initials: M
authors.lastname: Motallebi
authors.forename: S A
authors.initials: SA
authors.lastname: Mortazavi-Tabatabaei
authors.forename: A
authors.initials: A
authors.lastname: Kowsari
authors.forename: Z
authors.initials: Z
authors.lastname: Jafarian
authors.forename: H
authors.initials: H
authors.lastname: Darvish
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D059805:HLA-DR alpha-Chains / Q000235:genetics*; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D007492:Iran; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D059805:HLA-DR alpha-Chains