title: Electroacupuncture reduces injury to the blood-brain barrier following cerebral ischemia/ reperfusion injury.
abstract: This study used electroacupuncture at Renzhong (DU26) and Baihui (DU20) in a rat model of cerebral ischemia/reperfusion injury. Neurological deficit scores, western blotting, and reverse transcription-PCR results demonstrated that electroacupuncture markedly reduced neurological deficits, decreased corpus striatum aquaporin-4 protein and mRNA expression, and relieved damage to the blood-brain barrier in a rat model of cerebral ischemia/reperfusion injury. These results suggest that electroacupuncture most likely protects the blood-brain barrier by regulating aquaporin-4 expression following cerebral ischemia/reperfusion injury.
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Hesheng
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Sun
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Meijuan
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Acupuncture and Rehabilitation, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
authors.forename: Jihong
authors.initials: J
authors.lastname: Chu
keywords: Baihui (DU20); Renzhong (DU26); aquaporin-4; blood-brain barrier; brain edema; brain injury; cerebral ischemia/reperfusion; electroacupuncture; neural regeneration; rat; regeneration