title: Transient renal dysfunction with reversible splenial lesion.
abstract: We report the case of a 6-month-old boy with transient renal dysfunction who had an intensified signal in the splenium of the corpus callosum on magnetic resonance imaging. He presented to hospital with fever and sudden disturbance of consciousness. Cerebrospinal fluid analysis did not show pleocytosis. The mild consciousness disturbance disappeared after 30 min, but the splenial signal persisted even after 8 days. Further, renal glucosuria, increased excretion of select amino acids, and abnormal fractional excretion of electrolytes were observed, indicating renal tubular dysfunction. The abnormal urinary findings spontaneously resolved by day 9 of hospitalization. The splenial lesion took 21 days to normalize. There were no signs of neurological complications 2 months later. This case suggests the possibility of renal involvement in splenial lesions.
authors.affiliation: Department of Pediatrics, Iwata City Hospital, Iwata, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tomoka
authors.initials: T
authors.lastname: Matsuda
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Kitagata
authors.forename: Iwao
authors.initials: I
authors.lastname: Tajima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ono
authors.forename: Keiko
authors.initials: K
authors.lastname: Hirano
authors.forename: Masami
authors.initials: M
authors.lastname: Shirai
authors.forename: Akira
authors.initials: A
authors.lastname: Endoh
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hongo
mesh_terms: D001927:Brain Diseases / Q000150:complications*; D003337:Corpus Callosum; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000150:complications*; D008297:Male; D012075:Remission, Spontaneous
keywords: Fanconi syndrome; apparent life-threatening event; central nervous system symptom; corpus callosum; mild encephalitis/encephalopathy with reversible splenial lesion