title: Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation.
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA cmayeur@mgh.harvard.edu.
authors.forename: Claire
authors.initials: C
authors.lastname: Mayeur
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Starsha A
authors.initials: SA
authors.lastname: Kolodziej
authors.affiliation: Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Wang
authors.affiliation: Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
authors.forename: Arthur
authors.initials: A
authors.lastname: Lee
authors.affiliation: Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Paul B
authors.initials: PB
authors.lastname: Yu
authors.affiliation: Therapeutics for Rare and Neglected Diseases (TRND) Program, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, MD, USA.
authors.forename: John
authors.initials: J
authors.lastname: Shen
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Bloch
authors.affiliation: Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Donald B
authors.initials: DB
authors.lastname: Bloch
mesh_terms: D000284:Administration, Oral; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D000818:Animals; D001682:Biological Availability; D015153:Blotting, Western; D052005:Bone Morphogenetic Protein Receptors, Type I / Q000037:antagonists & inhibitors*; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000150:complications*; D007509:Irritants / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D011720:Pyrazoles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014018:Tissue Distribution; D014425:Turpentine / Q000633:toxicity
chemical_list: D019485:Bone Morphogenetic Proteins; D007509:Irritants; C554430:LDN 193189; D011720:Pyrazoles; D011743:Pyrimidines; D012333:RNA, Messenger; D052005:Bone Morphogenetic Protein Receptors, Type I; D014425:Turpentine
keywords: BMP inhibitor; anemia of inflammation; hepcidin