title: Effect of Probiotic Lactobacillus salivarius UBL S22 and Prebiotic Fructo-oligosaccharide on Serum Lipids, Inflammatory Markers, Insulin Sensitivity, and Gut Bacteria in Healthy Young Volunteers: A Randomized Controlled Single-Blind Pilot Study.
abstract: This study investigated the effect of 6-week supplementation of a probiotic strain Lactobacillus salivarius UBL S22 with or without prebiotic fructo-oligosaccharide (FOS) on serum lipid profiles, immune responses, insulin sensitivity, and gut lactobacilli in 45 healthy young individuals. The patients were divided into 3 groups (15/group), that is, placebo, probiotic, and synbiotic. After 6 weeks, a significant reduction (P < .05) in total cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides and increase in high-density lipoprotein cholesterol was observed in the probiotic as well as in the synbiotic group when compared to placebo; however, the results of total cholesterol and LDL-cholesterol were more pronounced in the synbiotic group. Similarly, when compared to the placebo group, the serum concentrations of inflammatory markers such as high sensitivity C-reactive protein, interleukin (IL) 6, IL-1β, and tumor necrosis factor α were significantly (P < .05) reduced in both the experimental groups, but again the reduction in the synbiotic group was more pronounced. Also, an increase (P < .05) in the fecal counts of total lactobacilli and a decrease (P < .05) in coliforms and Escherichia coli was observed in both the experimental groups after 6 weeks of ingestion. Overall, the combination of L salivarius with FOS was observed to be more beneficial than L salivarius alone, thereby advocating that such synbiotic combinations could be therapeutically exploited for improved health and quality of life.
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India.
authors.forename: Hemalatha
authors.initials: H
authors.lastname: Rajkumar
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India manoj15micro@yahoo.co.in.
authors.forename: Manoj
authors.initials: M
authors.lastname: Kumar
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India.
authors.forename: Nilita
authors.initials: N
authors.lastname: Das
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India.
authors.forename: S Nishanth
authors.initials: SN
authors.lastname: Kumar
authors.affiliation: Department of Microbiology and Immunology, National Institute of Nutrition, Hyderabad, Andhra Pradesh, India.
authors.forename: Hanumanth R
authors.initials: HR
authors.lastname: Challa
authors.affiliation: Division of Laboratories for Probiotic Research, Juntendo University Graduate School of Medicine, Tokyo, Japan.
authors.forename: Ravinder
authors.initials: R
authors.lastname: Nagpal
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D000069196:Gastrointestinal Microbiome; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D007778:Lactobacillus; D008055:Lipids / Q000097:blood*; D009844:Oligosaccharides / Q000494:pharmacology*; D056692:Prebiotics; D019936:Probiotics / Q000494:pharmacology*; D016037:Single-Blind Method; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014838:Volunteers
chemical_list: D015850:Interleukin-6; D008055:Lipids; D009844:Oligosaccharides; D056692:Prebiotics; D014409:Tumor Necrosis Factor-alpha; C116580:fructooligosaccharide; D002097:C-Reactive Protein
keywords: Lactobacillus salivarius; fructo-oligosaccharides; inflammation; insulin resistance; prebiotics; probiotics; synbiotics