title: Neuroprotective effect of pretreatment with ganoderma lucidum in cerebral ischemia/reperfusion injury in rat hippocampus.
abstract: Ganoderma lucidum is a traditional Chinese medicine, which has been shown to have both anti-oxidative and anti-inflammatory effects, and noticeably decreases both the infarct area and neuronal apoptosis of the ischemic cortex. This study aimed to investigate the protective effects and mechanisms of pretreatment with ganoderma lucidum (by intragastric administration) in cerebral ischemia/reperfusion injury in rats. Our results showed that pretreatment with ganoderma lucidum for 3 and 7 days reduced neuronal loss in the hippocampus, diminished the content of malondialdehyde in the hippocampus and serum, decreased the levels of tumor necrosis factor-α and interleukin-8 in the hippocampus, and increased the activity of superoxide dismutase in the hippocampus and serum. These results suggest that pretreatment with ganoderma lucidum was protective against cerebral ischemia/reperfusion injury through its anti-oxidative and anti-inflammatory actions.
authors.affiliation: Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China ; Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Wangxin
authors.initials: W
authors.lastname: Zhang
authors.affiliation: Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Quiling
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Deng
authors.affiliation: Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Yalu
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Guoqing
authors.initials: G
authors.lastname: Xing
authors.affiliation: Department of Medical Psychology, Taishan Medical University, Taian, Shandong Province, China.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Shi
authors.affiliation: Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China.
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Du
keywords: anti-inflammatory; anti-oxidative; apoptosis; cerebral ischemia/reperfusion; ganoderma lucidum; hippocampus; interleukin-8; malondialdehyde; nerve regeneration; neural regeneration; superoxide dismutase; tumor necrosis factor-α