title: Comparison of acoustic radiation force impulse imaging and transient elastography for non-invasive assessment of liver fibrosis in patients with chronic hepatitis B.
abstract: The aims of this study were to compare the performance of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) in the assessment of liver fibrosis in patients with chronic hepatitis B and to evaluate the impact of elevated alanine transaminase levels on liver stiffness assessment using ARFI elastography. One hundred eighty consecutive patients with chronic hepatitis B were enrolled in this study and evaluated with respect to histologic and biochemical features. All patients underwent ARFI elastography and TE. ARFI elastography and TE correlated significantly with histologically assessed fibrosis (r = 0.599, p < 0.001, for ARFI elastography; r = 0.628, p < 0.001, for TE) and necro-inflammatory activity (r = 0.591, p < 0.001, for ARFI elastography; r = 0.616, p < 0.001, for TE). Areas under the receiver operating characteristic curves for ARFI elastography and TE were 0.764 and 0.813 (p = 0.302, ≥stage 2), 0.852 and 0.852 (p = 1.000, ≥stage 3) and 0.825 and 0.799 (p = 0.655, S = 4), respectively. The optimum cutoff values for ARFI elastography were 1.63 m/s for stage ≥2, 1.74 m/s for stage ≥3 and 2.00 m/s for stage 4 in patients for whom alanine transaminase levels were evaluated. The cutoff values decreased to 1.24 m/s for ≥ stage 2, 1.32 m/s for ≥ stage 3 and 1.41 m/s for stage 4 in patients with normal alanine transaminase levels. ARFI elastography may be a reliable method for diagnosing the stage of liver fibrosis with diagnostic performance similar to that of TE in patients with chronic hepatitis B. In addition, liver stiffness values obtained with ARFI elastography, like those obtained with TE, may be influenced by alanine transaminase levels.
authors.affiliation: Department of Ultrasound, The 302 Hospital of PLA, Beijing, China. Electronic address: zdk002@163.com.
authors.forename: Dakun
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, The 302 Hospital of PLA, Beijing, China.
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.affiliation: Department of Ultrasound, The 302 Hospital of PLA, Beijing, China.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Ultrasound, The 302 Hospital of PLA, Beijing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, The 302 Hospital of PLA, Beijing, China.
authors.forename: Dedong
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Department of Ultrasound, The First Hospital Affiliated with Shanxi Medical University, Taiyuan, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology, The 302 Hospital of PLA, Beijing, China.
authors.forename: Guangde
authors.initials: G
authors.lastname: Zhou
mesh_terms: D000328:Adult; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Acoustic radiation force impulse elastography; Chronic hepatitis B; Liver fibrosis; Liver stiffness; Transient elastography