title: "In vitro" MRI findings of an agent can be used in the imaging of GABA receptors and similar agent's future projections.
abstract: OBJECTIVE
  The goal of this study was to analyze magnetic resonance imaging findings of gamma-amino butyric acid and gamma deuteroxy sodium butyrate and to evaluate possible "in vitro" and "in vivo" areas of use.
  
  
  METHODS
  Materials used included gamma-amino butyric acid and gamma deuteroxy sodium butyrate which is formed by the replacement of the deuteroxy group. An amino group in the gamma position of gamma-amino butyric acid was evaluated with a standard magnetic resonance device with the power of 1.5 Tesla and a brain coil. These findings have been compared.
  
  
  RESULTS
  Gamma deuteroxy sodium butyrate has shown to have statistically different signals than gamma-amino butyric acid, 0.09 NaCl, distilled water and gadolinium chelates.
  
  
  CONCLUSIONS
  Findings suggest that "in vivo" studies should be conducted in addition to phantom studies; Deuterium imaging may be used with or without proton imaging with technical support. Other agents may be studied for "in vivo" use following the labeling with Deuterium.
authors.affiliation: Department of Radiology, Elazig Training and Research Hospital, Elazig, Turkey. muratbaykara@hotmail.com.
authors.forename: M
authors.initials: M
authors.lastname: Baykara
authors.forename: G
authors.initials: G
authors.lastname: Kara
mesh_terms: D003287:Contrast Media; D066298:In Vitro Techniques; D008279:Magnetic Resonance Imaging / Q000379:methods*; D057054:Molecular Imaging; D018079:Receptors, GABA / Q000032:analysis* / Q000378:metabolism
chemical_list: D003287:Contrast Media; D018079:Receptors, GABA