title: Inefficient transmissibility of NS-truncated H3N8 equine influenza virus in dogs.
abstract: H3N8 equine influenza virus (EIV) causes respiratory diseases in the horse population, and it has been demonstrated that EIV can transmit into dogs owing to its availability on receptors of canine respiratory epithelial cells. Recently, we isolated H3N8 EIV from an EIV-vaccinated horse that showed symptoms of respiratory disease, and which has a partially truncated nonstructural gene (NS). However, it is not clear that the NS-truncated EIV has an ability to cross the host species barrier from horses to dogs as well. Here, we experimentally infected the NS-truncated H3N8 EIV into dogs, and monitored their clinical signs and viral load in respiratory organs to determine the virus's transmissibility.
authors.affiliation: Viral Infectious Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea, University of Science and Technology, Daejeon 305-350, Republic of Korea.
authors.forename: Woonsung
authors.initials: W
authors.lastname: Na
authors.forename: Manki
authors.initials: M
authors.lastname: Song
authors.forename: Minjoo
authors.initials: M
authors.lastname: Yeom
authors.forename: Nanuri
authors.initials: N
authors.lastname: Park
authors.forename: Bokyu
authors.initials: B
authors.lastname: Kang
authors.forename: Hyoungjoon
authors.initials: H
authors.lastname: Moon
authors.forename: Dae-Gwin
authors.initials: DG
authors.lastname: Jeong
authors.forename: Jeong-Ki
authors.initials: JK
authors.lastname: Kim
authors.forename: Daesub
authors.initials: D
authors.lastname: Song
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D004285:Dogs; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D058507:Host Specificity; D053123:Influenza A Virus, H3N8 Subtype / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D008168:Lung / Q000473:pathology / Q000648:ultrastructure; D009976:Orthomyxoviridae Infections / Q000473:pathology / Q000635:transmission / Q000662:veterinary* / Q000821:virology; D019562:Viral Load / Q000662:veterinary; D017361:Viral Nonstructural Proteins / Q000235:genetics*
chemical_list: D000914:Antibodies, Viral; C108309:NS protein, influenza virus; D017361:Viral Nonstructural Proteins