title: Ilf3 and NF90 functions in RNA biology.
abstract: Double-stranded RNA-binding proteins (DRBPs) are known to regulate many processes of RNA metabolism due, among others, to the presence of double-stranded RNA (dsRNA)-binding motifs (dsRBMs). Among these DRBPs, Interleukin enhancer-binding factor 3 (Ilf3) and Nuclear Factor 90 (NF90) are two ubiquitous proteins generated by mutually exclusive and alternative splicings of the Ilf3 gene. They share common N-terminal and central sequences but display specific C-terminal regions. They present a large heterogeneity generated by several post-transcriptional and post-translational modifications involved in their subcellular localization and biological functions. While Ilf3 and NF90 were first identified as activators of gene expression, they are also implicated in cellular processes unrelated to RNA metabolism such as regulation of the cell cycle or of enzymatic activites. The implication of Ilf3 and NF90 in RNA biology will be discussed with a focus on eukaryote transcription and translation regulation, on viral replication and translation as well as on noncoding RNA field.
authors.affiliation: Laboratoire de Biologie du développement, Institut de Biologie Paris-Seine, Sorbonne Universités, UPMC Univ Paris 06, Paris, France; Laboratoire de Biologie du développement, Institut de Biologie Paris-Seine, CNRS, UMR 7622, Paris, France.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Castella
authors.forename: Rozenn
authors.initials: R
authors.lastname: Bernard
authors.forename: Mélanie
authors.initials: M
authors.lastname: Corno
authors.forename: Aurélie
authors.initials: A
authors.lastname: Fradin
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Larcher
mesh_terms: D002453:Cell Cycle; D056890:Eukaryota; D005786:Gene Expression Regulation; D050779:Nuclear Factor 90 Proteins / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D012323:RNA Processing, Post-Transcriptional
chemical_list: D050779:Nuclear Factor 90 Proteins