title: [Experimental study of pinostrobine oxime biotransformation].
abstract: We have experimentally studied pathways of elimination of an oximized derivative of phytoflavonoid pinostrobine by HPLC/mass spectrometry. Four potential metabolites of pinostrobine oxime have been found and there was an attempt to determine their molecular structures on the basis of their fragmentation under positive electrospray ionization conditions. It is established that pinostrobine oxime is removed from the organism mainly unchanged and also in the form of glucuronated derivative.
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: D A
authors.initials: DA
authors.lastname: Abaimov
authors.forename: M V
authors.initials: MV
authors.lastname: Tankevich
authors.forename: D I
authors.initials: DI
authors.lastname: Prokhorov
authors.forename: S M
authors.initials: SM
authors.lastname: Adekenov
authors.forename: L I
authors.initials: LI
authors.lastname: Arystan
authors.forename: R D
authors.initials: RD
authors.lastname: Seĭfulla
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D001711:Biotransformation; D044950:Flavanones / Q000737:chemistry / Q000493:pharmacokinetics / Q000652:urine*; D005965:Glucuronates / Q000652:urine; D008297:Male; D010091:Oximes / Q000737:chemistry / Q000493:pharmacokinetics / Q000652:urine*; D020011:Protective Agents / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000975:Antioxidants; D044950:Flavanones; D005965:Glucuronates; D010091:Oximes; D020011:Protective Agents; C411294:pinostrobin