title: Peripheral arterial disease, type 2 diabetes and postprandial lipidaemia: Is there a link?
abstract: Peripheral arterial disease, manifested as intermittent claudication or critical ischaemia, or identified by an ankle/brachial index < 0.9, is present in at least one in every four patients with type 2 diabetes mellitus. Several reasons exist for peripheral arterial disease in diabetes. In addition to hyperglycaemia, smoking and hypertension, the dyslipidaemia that accompanies type 2 diabetes and is characterised by increased triglyceride levels and reduced high-density lipoprotein cholesterol concentrations also seems to contribute to this association. Recent years have witnessed an increased interest in postprandial lipidaemia, as a result of various prospective studies showing that non-fasting triglycerides predict the onset of arteriosclerotic cardiovascular disease better than fasting measurements do. Additionally, the use of certain specific postprandial particle markers, such as apolipoprotein B-48, makes it easier and more simple to approach the postprandial phenomenon. Despite this, only a few studies have evaluated the role of postprandial triglycerides in the development of peripheral arterial disease and type 2 diabetes. The purpose of this review is to examine the epidemiology and risk factors of peripheral arterial disease in type 2 diabetes, focusing on the role of postprandial triglycerides and particles.
authors.affiliation: Pedro Valdivielso, José Ramírez-Bollero, Carmen Pérez-López, UGC de Medicina Interna, Hospital "Virgen de la Victoria" de Málaga y Departamento de Medicina y Dermatología, Universidad de Málaga, 29010 Málaga, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Valdivielso
authors.affiliation: Pedro Valdivielso, José Ramírez-Bollero, Carmen Pérez-López, UGC de Medicina Interna, Hospital "Virgen de la Victoria" de Málaga y Departamento de Medicina y Dermatología, Universidad de Málaga, 29010 Málaga, Spain.
authors.forename: José
authors.initials: J
authors.lastname: Ramírez-Bollero
authors.affiliation: Pedro Valdivielso, José Ramírez-Bollero, Carmen Pérez-López, UGC de Medicina Interna, Hospital "Virgen de la Victoria" de Málaga y Departamento de Medicina y Dermatología, Universidad de Málaga, 29010 Málaga, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pérez-López
keywords: Ankle-brachial index; Apolipoprotein B-48; Non-fasting triglycerides; Peripheral arterial disease; Postprandial lipidaemia; Type 2 diabetes