title: Myelodysplasia in children: report of 2 cases.
abstract: Myelodysplasia in children is rare. We report two cases presenting with pancytopaenia and macrocytosis with additional features suggestive of Fanconi anemia which is an autosomal recessive disorder in which there is progressive bone marrow failure and increased predisposition to malignancies especially AML. Hypersensitivity of FA cells to the chromosome-breaking effect of cross-linking agents provides a reliable cellular marker for the diagnosis of this disorder.
authors.affiliation: Department of Pathology, Amala Institute of Medical Sciences, Amalanagar, Thrissur, 680555, Kerala India ; G2, Sri Sai Apartments, Kunnath Mana Lane, Thrissur, 680001 Kerala India.
authors.forename: M C
authors.initials: MC
authors.lastname: Savithri
authors.affiliation: Department of Pathology, Amala Institute of Medical Sciences, Amalanagar, Thrissur, 680555, Kerala India.
authors.forename: K P
authors.initials: KP
authors.lastname: Kavitha
authors.affiliation: Department of Pathology, Amala Institute of Medical Sciences, Amalanagar, Thrissur, 680555, Kerala India.
authors.forename: Vanesa
authors.initials: V
authors.lastname: John
keywords: Fanconi anemia; Pancytopenia; Pediatric myelodysplasia