title: [Neurotrophins up-express in peripheral blood of allergic rhinitis patients and related to Th2 hypothesis].
abstract: OBJECTIVE
  To detect the expression of NGF, BDNF, NT-3 mRNA in the peripheral blood of patients with allergic rhinitis (AR). And to analyze the correlation between NGF, BDNF, NT-3 mRNA expression and the epidsode of rhinitis through Th-2 Hypothesis.
  
  
  METHODS
  This study was a group controlled trial. The expression of NGF, BDNF and NT-3 mRNA were tested by real-time quantitative RT-PCR and the concentrations of IL-4, IL-6, IL-10 and INF-alpha were tested by ELISA.
  
  
  RESULTS
  The expression of NGF, BDNF and NT-3 mRNA in AR patients were 2.44, 4.46 and 1.78 times the amount of those in the healthy adults, respectively. The increased expression of NT-3 correlated positively with the scores of visual analog scale of AR. The concentrations of IL-4, IL-6 and IL-10, which were 2198 +/- 472 pg/mL, 9407 +/- 703 pg/mL and 3917 +/- 323 pg/mL respectively, were higher than those in the healthy adults. The concentration of INF-alpha was 2198 +/- 472 pg/mL and less than the healthy adults. The increased expressions of NGF, NT-3 were positively related to the increase of IL-4, IL-6 and IL-10.
  
  
  CONCLUSIONS
  The expressions of NGF, BDNF and NT-3 mRNA in AR patients are higher than those in the healthy adults. NGF, BDNF and NT-3 may contribute to the pathogenesis of AR. Moreover, NGF and NT-3 may induce the episode of rhinitis through Th-2 Hypothesis.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Renhui
authors.initials: R
authors.lastname: Chen
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Geng
authors.forename: Ciyun
authors.initials: C
authors.lastname: Xu
authors.forename: Weibiao
authors.initials: W
authors.lastname: Kang
authors.forename: Yulong
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D020932:Nerve Growth Factor / Q000097:blood; D009414:Nerve Growth Factors / Q000097:blood* / Q000235:genetics; D020933:Neurotrophin 3 / Q000097:blood; D012333:RNA, Messenger / Q000235:genetics; D065631:Rhinitis, Allergic / Q000097:blood* / Q000276:immunology; D058408:Th1-Th2 Balance; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C508609:IL10 protein, human; C508598:IL4 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D009414:Nerve Growth Factors; D020933:Neurotrophin 3; D012333:RNA, Messenger; C019277:brain-derived growth factor; D016753:Interleukin-10; D015847:Interleukin-4; D020932:Nerve Growth Factor