title: [The effect of immunotherapy and hyperthermia for advanced or recurrent head and neck cancer - 74 clinical cases].
abstract: We treated 74 patients with advanced or recurrent head and neck cancer using hyperthermia and/or immunotherapy between July 2005 and November 2013. Standard therapy showed no effect or was refused by these patients. Fifteen(21.4%) patients experienced a clinical benefit(complete response[CR], partial response[PR], and long-term stable disease[SD], >6 months), including 4 CR cases. Hyperthermia alone was effective for one patient only. A combination of dendritic cell therapy and hyperthermia was beneficial for the remaining 14 patients. One patient was effectively treated with cetuximab, and γδ lymphocytes and dendritic cell therapy.
authors.affiliation: Osaka Cancer Immuno-Chemotherapy Center.
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takeda
authors.forename: Chieri
authors.initials: C
authors.lastname: Tanaka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Maruhashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
mesh_terms: D003131:Combined Modality Therapy; D006258:Head and Neck Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D012008:Recurrence