title: Rapid interrogation of the physical and chemical characteristics of salbutamol sulphate aerosol from a pressurised metered-dose inhaler (pMDI).
abstract: Individual micron-sized solid particles from a Salamol® pharmaceutical inhaler are stably captured in air using an optical trap for the first time. Raman spectroscopy of the levitated particles allows online interrogation of composition and deliquescent phase change within a high humidity environment that mimics the particle's travel from inhaler to lung.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Tong
authors.forename: C
authors.initials: C
authors.lastname: Fitzgerald
authors.forename: P J
authors.initials: PJ
authors.lastname: Gallimore
authors.forename: M
authors.initials: M
authors.lastname: Kalberer
authors.forename: M K
authors.initials: MK
authors.lastname: Kuimova
authors.forename: P C
authors.initials: PC
authors.lastname: Seville
authors.forename: A D
authors.initials: AD
authors.lastname: Ward
authors.forename: F D
authors.initials: FD
authors.lastname: Pope
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000008:administration & dosage* / Q000737:chemistry; D000420:Albuterol / Q000008:administration & dosage* / Q000737:chemistry; D001993:Bronchodilator Agents / Q000008:administration & dosage* / Q000737:chemistry; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D013059:Spectrum Analysis, Raman
chemical_list: D000336:Aerosols; D001993:Bronchodilator Agents; D000420:Albuterol