title: [Using intracameral cefuroxime reduces postoperative endophthalmitis rate: 5 years experience at the University Eye Hospital Tübingen].
abstract: BACKGROUND
  Cataract surgery is the most commonly performed surgical procedure in developed countries. The annual number of cataract surgeries in Germany is about 600,000. Acute postoperative endophthalmitis is a very severe and the most dreaded complication of cataract surgery. Various operative and non-operative measures have been suggested to prevent this serious complication. The European Society of Cataract & Refractive Surgeons (ESCRS) study of intracameral cefuroxime was the first prospective, randomised and partially placebo-controlled clinical trial showing the efficacy of antibiotic prophylaxis to prevent endophthalmitis in 2007. The aim of this retrospective study is to investigate a possible reduction of intracameral cefuroxime to prevent postoperative endophthalmitis at the University Eye Hospital Tübingen.
  
  
  METHODS
  During the period from January 2002 to August 2013, 2 time periods were determined based on the adoption of intracameral cefuroxime injections after cataract surgery. From January 2002 to May 2009 patients received at the end of cataract surgery a subconjunctival administration of 50 mg of mezlocillin and postoperative antibiotic eye drops (gentamicin) without intracameral injection. From June 2009 to August 2013, patients received an intracameral injection of cefuroxime while antibiotic drops (moxifloxacin) were used too. The rates of postoperative infectious endophthalmitis during these 2 periods were calculated.
  
  
  RESULTS
  31 cases of endophthalmitis occurred in 31,386 cataract surgeries. The overall cumulative incidence was 0.99 per 1000 patients. The incidence in the first period without intracameral cefuroxime injection was 1.38 (95 % confidence interval [CI]: 1.03-1.72) per 1000 patients and in the second period 0.44 (95 % CI: 0.34-0.54) per 1000 patients (p < 0.001).
  
  
  CONCLUSIONS
  Intracameral injection of cefuroxime reduces the rate of postoperative infectious endophthalmitis in cataract surgery significantly.
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: T
authors.initials: T
authors.lastname: Röck
authors.affiliation: Abteilung für Allgemeinmedizin, Ruhr-Universität Bochum.
authors.forename: M
authors.initials: M
authors.lastname: Bramkamp
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: K-U
authors.initials: KU
authors.lastname: Bartz-Schmidt
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: U
authors.initials: U
authors.lastname: Mutlu
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: E
authors.initials: E
authors.lastname: Yörük
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: D
authors.initials: D
authors.lastname: Röck
authors.affiliation: Department für Augenheilkunde, Eberhard Karls Universität Tübingen.
authors.forename: S
authors.initials: S
authors.lastname: Thaler
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D019072:Antibiotic Prophylaxis / Q000379:methods / Q000706:statistics & numerical data*; D002387:Cataract Extraction / Q000706:statistics & numerical data*; D015984:Causality; D002444:Cefuroxime / Q000008:administration & dosage*; D015897:Comorbidity; D009877:Endophthalmitis / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control*; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology* / Q000517:prevention & control*; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002444:Cefuroxime