title: Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease.
abstract: The effect of Lactobacillus plantarum NCU116 on liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease (NAFLD) was studied. The rats were divided into four groups: the normal diet (ND) group; the high fat diet (HFD) group; and HFD plus L. plantarum NCU116 as two doses (NCU116-L, 10(8) CFU mL(-1); NCU116-H, 10(9) CFU mL(-1)) groups. Treatment of L. plantarum NCU116 for 5 weeks was found to restore liver function and oxidative stress in rats with NAFLD, and decrease the levels of fat accumulation in the liver. In addition, the bacterium significantly reduced endotoxin and proinflammatory cytokines, and regulated bacterial flora in the colon and the expression of lipid metabolism in the liver. These results suggest that possible underlying mechanisms for the beneficial effect of L. plantarum NCU116 on NAFLD may include two pathways of downregulating lipogenesis and upregulating lipolysis and fatty acid oxidation related gene expression.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. myxie@ncu.edu.cn spnie@ncu.edu.cn.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Ke-Xue
authors.initials: KX
authors.lastname: Zhu
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ding
authors.forename: Chang
authors.initials: C
authors.lastname: Li
authors.forename: Tao
authors.initials: T
authors.lastname: Xiong
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism / Q000382:microbiology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000178:diet therapy* / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology; D018384:Oxidative Stress; D019936:Probiotics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016207:Cytokines