title: Cellular mechanisms of the 5-HT7 receptor-mediated signaling.
abstract: Serotonin (5-hydroxytryptamine or 5-HT) is an important neurotransmitter regulating a wide range of physiological and pathological functions via activation of heterogeneously expressed 5-HT receptors. The 5-HT7 receptor is one of the most recently described members of the 5-HT receptor family. Functionally, 5-HT7 receptor is associated with a number of physiological and pathological responses, including serotonin-induced phase shifting of the circadian rhythm, control of memory as well as locomotor and exploratory activity. A large body of evidence indicates involvement of the 5-HT7 receptor in anxiety and depression, and recent studies suggest that 5-HT7 receptor can be highly relevant for the treatment of major depressive disorders. The 5-HT7 receptor is coupled to the stimulatory Gs-protein, and receptor stimulation results in activation of adenylyl cyclase (AC) leading to a rise of cAMP concentration. In addition, this receptor is coupled to the G12-protein to activate small GTPases of the Rho family. This review focuses on molecular mechanisms responsible for the 5-HT7 receptor-mediated signaling. We provide detailed overview of signaling cascades controlled and regulated by the 5-HT7 receptor and discuss the functional impact of 5-HT7 receptor for the regulation of different cellular and subcellular processes.
authors.affiliation: Department of Cellular Neurophysiology, Hannover Medical School Hannover, Germany.
authors.forename: Daria
authors.initials: D
authors.lastname: Guseva
authors.affiliation: Department of Cellular Neurophysiology, Hannover Medical School Hannover, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Wirth
authors.affiliation: Department of Cellular Neurophysiology, Hannover Medical School Hannover, Germany.
authors.forename: Evgeni
authors.initials: E
authors.lastname: Ponimaskin
keywords: G-protein coupled receptors; heterotrimeric G-protein; oligomerization; palmitoylation; serotonergic signaling; serotonin 5-HT7 receptor