title: Effects of flaxseed flour on the lipid profile of rats submitted to prolonged androgen stimuli.
abstract: BACKGROUND
  The chronic use of steroid hormones can lead to alterations in the lipid profile such as an increase in LDL and decrease in HDL levels . The effect of flaxseed on lipid profiles has been widely investigated.
  
  
  OBJECTIVE
  Evaluate the lipid profile of adult male Wistar rats fed with flax based meals and submitted to androgenic hyperstimulation.
  
  
  METHODS
  Forty Wistar rats were divided into 4 groups of 10 animals: the Control group (CG); Flax group (FG) fed a flaxseed flour-based meal; Induced group (IG); and the Induced group (IGF) that was fed a flaxseed flour-based meal. The induction was done by using silicone pellets filled with testosterone propionate (1mg), sealed with a surgical adhesive and substituted every 4 weeks.
  
  
  RESULTS
  Triglycerides (FG: 71.16 ± 21.95; IG: 99.16 ± 26.00 and IGF: 86.33 ± 27.16 mg/dL) and HDL-cholesterol (FG: 23.05 ± 1.67; IG: 29.06 ± 7.24 and IGF: 26.06 ± 3.56 mg/dL) were significantly lower in the experimental groups. The FG and IGF (41.16 ± 3.97 and 49.66 ± 11.25 mg/dL, respectively) showed significantly lower levels of cholesterol than the other groups(CG: 78,85 ± 11.58 and IG: 70,83 ± 14.85 mg/dL). Regarding LDL levels, the IG showed significantly higher concentrations (21,93 ± 8,84 mg/dL) than the others groups (CG: 7,81 ± 5,37; FG: 3,88 ± 1,32 and IGF: 6,66 ± 7,24 mg/dL).
  
  
  CONCLUSIONS
  The flaxseed has a relevant effect on the lipid profile of animals submitted to androgenic hyperstimulation.
authors.affiliation: Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. ilmavetuff@gmail.com.
authors.forename: Ilma Cely de Amorim
authors.initials: IC
authors.lastname: Ribeiro
authors.affiliation: Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. carlosnut@ibest.com.br.
authors.forename: Carlos Alberto Soares
authors.initials: CA
authors.lastname: da Costa
authors.affiliation: Department of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rio de Janeiro, Brazil.. ap_vivian@hotmail.com.
authors.forename: Vivian
authors.initials: V
authors.lastname: Alves Pereira
authors.affiliation: Department of Morphology, Laboratory of Cellular and Extracellular Biomorphology Biomedic Institute, Federal Fluminense University. Brasil.. gilsontb@gmail.com.
authors.forename: Gilson
authors.initials: G
authors.lastname: Teles Boaventura
authors.affiliation: Department of Nutrition and Dietetics, Experimental Nutrition Laboratory, College of Nutrition, Federal Fluminense University, Rio de Janeiro, Brazil.. chagas.m@gmail.com.
authors.forename: Mauricio
authors.initials: M
authors.lastname: Alves Chagas
mesh_terms: D000728:Androgens / Q000008:administration & dosage*; D000818:Animals; D002784:Cholesterol / Q000097:blood*; D019597:Flax; D005433:Flour; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D000728:Androgens; D014280:Triglycerides; D002784:Cholesterol