title: The Effect of Acetyl Salicylic Acid Induced Nitric Oxide Synthesis in the Normalization of Hypertension through the Stimulation of Renal Cortexin Synthesis and by the Inhibition of Dermcidin Isoform 2, A Hypertensive Protein Production.
abstract: Currently, there is no specific medication for essential hypertension (EH), a major form of the condition, in man. As acetyl salicylic acid (aspirin) is reported to stimulate the synthesis of renal (r)-cortexin, an anti-essential hypertensive protein, and, as aspirin is reported to inhibit dermcidin isoform 2 (dermcidin), a causative protein for EH, the role of aspirin in the control of EH in man was studied. Oral administration of 150 mg aspirin/70 kg body weight in subjects with EH was found to reduce both the elevated systolic and diastolic blood pressures to normal levels within 3 h due to the normalization of dermcidin level in these subjects. The plasma cortexin level at day 0, 1, 30 and 90 were 0.5 pmol/ml, 155.5 pmol/ml, 160.2 pmol/ml, 190.5 pmol/ml respectively with increased NO synthesis (r=+0.994). In vitro studies demonstrated that the incubation of the goat kidney cortex cells with aspirin stimulated (r)-cortexin synthesis due to NO synthesis. It could be suggested that the use of aspirin might control EH in man.
authors.affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;
authors.forename: Rajeshwary
authors.initials: R
authors.lastname: Ghosh
authors.affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;
authors.forename: Sarbashri
authors.initials: S
authors.lastname: Bank
authors.affiliation: Sinha Institute of Medical Science and Technology, Garia 700084, India;
authors.forename: Uttam K
authors.initials: UK
authors.lastname: Maji
authors.affiliation: Gandhi Memorial Hospital, Kalyani, 741245, West Bengal, India;
authors.forename: Rabindra
authors.initials: R
authors.lastname: Bhattacharya
authors.affiliation: Dept. Of Cardiology, Calcutta Medical College and Hospital, Kolkata, India;
authors.forename: Santanu
authors.initials: S
authors.lastname: Guha
authors.affiliation: RR&D Center of Excellence, James J. Peters VA Medical Center, 130 W. Kingsbridge Road, Bronx, NY, USA;
authors.forename: Nighat N
authors.initials: NN
authors.lastname: Khan
authors.affiliation: Sinha Institute of Medical Science & Technology, 288, Kendua main road, Garia, 700 084, India.
authors.forename: A Kumar
authors.initials: AK
authors.lastname: Sinha
keywords: (r)-Cortexin; Antihypertensive medications; Aspirin; Dermcidin Isoform 2; Nitric Oxide