title: Newly discovered olfactory receptors in epidermal keratinocytes are associated with proliferation, migration, and re-epithelialization of keratinocytes.
abstract: Skin contains receptors for various environmental factors. In this issue of the Journal, Busse et al. cloned a new olfactory receptor, OR2AT4, in keratinocytes. They show that the activation of OR2AT4 induces phosphorylation of extracellular signal-regulated kinases and p38 mitogen-activated protein kinases, and that it accelerates wound healing. OR2AT4 may be a promising candidate as a target in clinical drug development.
authors.affiliation: Shiseido Research Center, Yokohama, Japan; Japan Science and Technology Agency, CREST, Tokyo, Japan. Electronic address: mitsuhiro.denda@to.shiseido.co.jp.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Denda
mesh_terms: D005786:Gene Expression Regulation; D006801:Humans; D015603:Keratinocytes / Q000166:cytology* / Q000378:metabolism*; D018035:Receptors, Odorant / Q000378:metabolism*; D032123:Santalum / Q000737:chemistry*; D014945:Wound Healing
chemical_list: C000595261:OR2AT4 protein, human; D018035:Receptors, Odorant