title: Antitumor immunity by magnetic nanoparticle-mediated hyperthermia.
abstract: Magnetic nanoparticle-mediated hyperthermia (MNHT) generates heat to a local tumor tissue of above 43°C without damaging surrounding normal tissues. By applying MNHT, a significant amount of heat-shock proteins is expressed within and around the tumor tissues, inducing tumor-specific immune responses. In vivo experiments have indicated that MNHT can induce the regression of not only a local tumor tissue exposed to heat, but also distant metastatic tumors unexposed to heat. In this article, we introduce recent progress in the application of MNHT for antitumor treatments and summarize the mechanisms and processes of its biological effects during antitumor induction by MNHT. Several clinical trials have been conducted indicating that the MNHT system may add a promising and novel approach to antitumor therapy.
authors.affiliation: Research Institute for Biological Functions, Chubu University, Matsumoto-cho 1200, Kasugai, Aichi 487-8501, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kakimi
authors.forename: Eiichi
authors.initials: E
authors.lastname: Nakayama
authors.forename: Kowichi
authors.initials: K
authors.lastname: Jimbow
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells; D000970:Antineoplastic Agents / Q000737:chemistry*; D002986:Clinical Trials as Topic; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007107:Immune System; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods*; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013696:Temperature
chemical_list: D000970:Antineoplastic Agents; D018840:HSP70 Heat-Shock Proteins; D058185:Magnetite Nanoparticles
keywords: antitumor therapy; heat-shock proteins; hyperthermia; immune response; magnetic nanoparticles; tumor immunity