title: First total synthesis of ganglioside DSG-A possessing neuritogenic activity.
abstract: The first total synthesis of ganglioside DSG-A (1) is achieved via chemoselective glycosylation and a [1 + 1 + 2] synthetic strategy. We have also developed an efficient method that can be handled on large scale (50 g) for the synthesis of the phytosphingosine.
authors.affiliation: Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li, 32023, Taiwan. tsaiyofu@cycu.edu.tw.
authors.forename: Yu-Fa
authors.initials: YF
authors.lastname: Wu
authors.forename: Yow-Fu
authors.initials: YF
authors.lastname: Tsai
authors.forename: Jhe-Ruei
authors.initials: JR
authors.lastname: Guo
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Yu
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Yu
authors.forename: Chun-Chen
authors.initials: CC
authors.lastname: Liao
mesh_terms: D000818:Animals; D005732:Gangliosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006031:Glycosylation; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D005732:Gangliosides; C012491:phytosphingosine; D013110:Sphingosine