title: Association between HLA-DR4 haplotypes and tuberculin skin test response in the Aché population.
abstract: The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Evidence for association with tuberculosis (TB) is more consistent for class II than for class I HLA genes. TB is important among indigenous peoples in South America, not only because of its historical role in regional depopulation, but also because it is still widespread. The aim of this study was to evaluate the association of HLA class II alleles, haplotypes and genotypes and tuberculin skin test response (TST) in 76 individuals of the Aché population. Poisson Regression was employed to assess risk genotypes. DRB1*04, DQA1*03 and DQB1*03:02 were associated with TST response in this population.
authors.affiliation: Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: J D
authors.initials: JD
authors.lastname: Lindenau
authors.forename: L S P
authors.initials: LS
authors.lastname: Guimarães
authors.forename: A M
authors.initials: AM
authors.lastname: Hurtado
authors.forename: K R
authors.initials: KR
authors.lastname: Hill
authors.forename: L T
authors.initials: LT
authors.lastname: Tsuneto
authors.forename: F M
authors.initials: FM
authors.lastname: Salzano
authors.forename: M L
authors.initials: ML
authors.lastname: Petzl-Erler
authors.forename: M H
authors.initials: MH
authors.lastname: Hutz
mesh_terms: D000483:Alleles; D001938:Brazil; D005260:Female; D059848:HLA-DQ alpha-Chains / Q000235:genetics; D059866:HLA-DQ beta-Chains / Q000235:genetics; D015804:HLA-DR4 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American; D008297:Male; D014374:Tuberculin Test; D014376:Tuberculosis / Q000235:genetics*
chemical_list: D059848:HLA-DQ alpha-Chains; D059866:HLA-DQ beta-Chains; C069050:HLA-DQA1 antigen; C069051:HLA-DQB1 antigen; D015804:HLA-DR4 Antigen; D059811:HLA-DRB1 Chains
keywords: Amerindians; anergy; human leukocyte antigen; tuberculin skin test response response; tuberculosis