title: Association of FSH with metabolic syndrome in postmenopausal women: a comparison with CRP, adiponectin and leptin.
abstract: OBJECTIVE
  The aim of this study was to evaluate the usefulness of follicle-stimulating hormone (FSH) determination in the postmenopausal women with metabolic syndrome (MetS) in a comparative analysis with biomarkers such as C-reactive protein (CRP), adiponectin, leptin and leptin-to-adiponectin ratio (L/A).
  
  
  METHODS
  135 postmenopausal women with MetS and 153 without MetS were subjected to examinations.
  
  
  RESULTS
  The increase in the probability of MetS, when the value of the marker concentration decreased or increased by 1 standard deviation, was two times higher for FSH-based models than for models including CRP and leptin, and was similar to models including adiponectin and L/A. The areas under the ROC curves were 0.78 for FSH, 0.68 for CRP, 0.72 for leptin, 0.76 for adiponectin and 0.80 for L/A.
  
  
  CONCLUSIONS
  Our results suggest that the FSH concentration assesses the probability of MetS similarly to L/A or adiponectin and better than CRP or leptin in postmenopausal women.
authors.affiliation: Department of Laboratory Medicine, Collegium Medicum, Nicholas Copernicus University, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Stefanska
authors.forename: Irena
authors.initials: I
authors.lastname: Ponikowska
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Cwiklinska-Jurkowska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Sypniewska
mesh_terms: D052242:Adiponectin / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D020738:Leptin / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein
keywords: C-reactive protein; adiponectin; follicle-stimulating hormone; leptin; menopause; metabolic syndrome