title: Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study.
abstract: BACKGROUND
  We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin(®) (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration-time curve of Theracurmin in humans was 27-fold higher than that of curcumin powder. We determined the clinical effects of orally administered Theracurmin in patients with knee osteoarthritis during 8 weeks of treatment.
  
  
  METHODS
  Fifty patients with knee osteoarthritis of Kellgren-Lawrence grade II or III and who were aged more than 40 years were enrolled in this randomized, double-blind, placebo-controlled, prospective clinical study. Placebo or Theracurmin containing 180 mg/day of curcumin was administered orally every day for 8 weeks. To monitor adverse events, blood biochemistry analyses were performed before and after 8 weeks of each intervention. The patients' knee symptoms were evaluated at 0, 2, 4, 6, and 8 weeks by the Japanese Knee Osteoarthritis Measure, the knee pain visual analog scale (VAS), the knee scoring system of the Japanese Orthopedic Association, and the need for nonsteroidal anti-inflammatory drugs.
  
  
  RESULTS
  At 8 weeks after treatment initiation, knee pain VAS scores were significantly lower in the Theracurmin group than in the placebo group, except in the patients with initial VAS scores of 0.15 or less. Theracurmin lowered the celecoxib dependence significantly more than placebo. No major side effects were observed with Theracurmin treatment.
  
  
  CONCLUSIONS
  Theracurmin shows modest potential for the treatment of human knee osteoarthritis.
authors.affiliation: Department of Orthopedic Surgery, National Hospital Organization, Kyoto Medical Center, 1-1 Fukakusa Mukaihata-cho Fushimi-ku, Kyoto, 612-8555, Japan, yanakaga@kyotolan.hosp.go.jp.
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Shogo
authors.initials: S
authors.lastname: Mukai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Yamada
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Eri
authors.initials: E
authors.lastname: Tarumi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Chieko
authors.initials: C
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Imaizumi
authors.forename: Jun
authors.initials: J
authors.lastname: Nishihira
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics; D001682:Biological Availability; D003474:Curcumin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies; D011859:Radiography; D016059:Range of Motion, Articular / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003474:Curcumin