title: Levetiracetam effect on adult-onset temporal lobe epilepsy with positive voltage-gated potassium channel antibody.
abstract: Temporal lobe epilepsy is considered to be the most frequent of all epileptic syndromes. Recently, several retrospective studies suggest that limbic encephalitis (LE) may be a cause for adult onset unexplained seizure disorders in patients. This report describes two cases of adult onset epilepsy with voltage-gated potassium channel antibodies (VGKC-abs)-associated LE that responded well to levetiracetam (LEV). As demonstrated by these two cases and reviewing previous reports, we propose that the therapeutic regimen for VGKC-abs associated seizures still needs to be determined and LEV may be effective in treating this kind of disorders.
authors.affiliation: From the Dept. of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Xiao
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Dong
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000906:Antibodies / Q000097:blood*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004833:Epilepsy, Temporal Lobe / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008875:Middle Aged; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D049268:Positron-Emission Tomography; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D000906:Antibodies; D000927:Anticonvulsants; D024642:Potassium Channels, Voltage-Gated; D000077287:Levetiracetam; D010889:Piracetam