title: [Thrombopathy induced by selective serotonin reuptake inhibitors: a case report].
abstract: We report the case of a 20 years old man presenting two episodes of hematemesis. The patient was known to suffer from depression and was treated with sertraline (Zoloft®) for 6 months at the dosage of 100 mg/day. No endoscopic and radiological abnormality was found. The haemostasis report was normal. Exploration of platelet function was in favor of an abnormality of platelet secretion as evidenced by low epinephrine-induced aggregation, a slightly reduced aggregation for following agonists: TRAP, ADP 5 μM and 10 μM, and a longer latency to collagen. The diagnosis of an acquired platelet disorder was strongly suspected and in particular an acquired platelet disorder induced by selective serotonin reuptake inhibitors that is known to interfere with platelet activation pathways involving serotonin.
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ben Said
authors.affiliation: AP-HP, Service d'hypertension artérielle, Hôpital européen Georges Pompidou, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Amar
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France, Inserm UMR-S1140, Université Paris Descartes, Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Smadja
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Rivet
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Bertil
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France, Inserm UMR-S970, PARCC, Université Paris Descartes, Paris, France.
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Fischer
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France, Inserm UMR-S970, PARCC, Université Paris Descartes, Paris, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Helley
authors.affiliation: AP-HP, Service d'hématologie biologique, Hôpital européen Georges Pompidou, Paris, France, Inserm UMR-S1140, Université Paris Descartes, Paris, France.
authors.forename: Pascale
authors.initials: P
authors.lastname: Gaussem
mesh_terms: D003865:Major Depressive Disorder / Q000188:drug therapy; D006801:Humans; D008297:Male; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline
keywords: bleeding; platelet aggregation; selective serotonin reuptake inhibitors; thrombopathy