title: Host response biomarkers in sepsis: overview on sTREM-1 detection.
abstract: The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. TREM-1, the triggering receptor expressed on myeloid cells-1, is an amplifier of the innate immune response. Its soluble form acts as a decoy for the natural TREM-1 ligand and dampens its activation. In this chapter, we review the numerous studies that have evaluated the usefulness of sTREM-1 concentration determination for the diagnosis and the prognosis evaluation of sepsis or localized infection. Nowadays, sandwich ELISA kits are available and the assay is described.
authors.affiliation: Department of Medical Intensive Care, Hôpital Central, 29 avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France.
authors.forename: Jérémie
authors.initials: J
authors.lastname: Lemarié
authors.forename: Damien
authors.initials: D
authors.lastname: Barraud
authors.forename: Sébastien
authors.initials: S
authors.lastname: Gibot
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D015870:Gene Expression; D006801:Humans; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors / Q000097:blood* / Q000235:genetics / Q000276:immunology; D051379:Mice; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D010455:Peptides / Q000494:pharmacology; D011379:Prognosis; D051381:Rats; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors / Q000097:blood* / Q000235:genetics / Q000276:immunology; D018805:Sepsis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D015415:Biomarkers; D008562:Membrane Glycoproteins; D010455:Peptides; D011971:Receptors, Immunologic; C408842:TREM1 protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1; D002097:C-Reactive Protein