title: Normal mitral annulus dynamics and its relationships with left ventricular and left atrial function.
abstract: Mitral annulus (MA) geometry and dynamics are crucial for preserving normal mitral valve (MV) function. Static reference values for MA parameters have been reported, but the normal MA dynamics during the entire cardiac cycle remains controversial. MV full-volume datasets were obtained by three-dimensional transthoracic echocardiography from 50 healthy volunteers (18-74 years; 31 men) to assess MA changes in size and shape during entire cardiac cycle. Using simultaneous multiplanar review, projected MA area (MAA) and circumference (MAC), antero-posterior (AP) and anterolateral-posteromedial (ALPM) diameters, and sphericity index (SphI) were obtained at: mitral valve closure (MVC), mid- and end-systole (ES), early- (EDF) and late-diastolic filling, and end-diastole. MAA and AP diameter were the most "active" parameters, changing in all reference frames (p < 0.001). MAA and AP diameter started to contract before MVC (during the left atrial contraction), reaching their minimum at MVC. Maximum MAA occurred at ES, while maximum AP diameter and SphI occurred at EDF. MAA fractional shortening was 35 ± 10 %. AP diameter change was 25 ± 10 %. MAC, ALPM and SphI showed similar patterns during left ventricular (LV) systole, and remained unchanged during diastole. Fractional change was 35 ± 10 % for MAC, and 13 ± 8 % for ALPM diameter. Our study provides the normal dynamics of the MA during the entire cardiac cycle. It reveals "pre-systolic" contraction of the MA, related to left atrial (LA) contraction, and minimal MAA during early LV systole. Therefore, the normal MA dynamics relates to a "physiologic LA-LV coupling", and a complete MA contraction requires both and properly timed LA and LV systole.
authors.affiliation: Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Via Giustiniani 2, 35128, Padua, Italy, sorinamihaila@yahoo.com.
authors.forename: Sorina
authors.initials: S
authors.lastname: Mihaila
authors.forename: Denisa
authors.initials: D
authors.lastname: Muraru
authors.forename: Marcelo Haertel
authors.initials: MH
authors.lastname: Miglioranza
authors.forename: Eleonora
authors.initials: E
authors.lastname: Piasentini
authors.forename: Diletta
authors.initials: D
authors.lastname: Peluso
authors.forename: Umberto
authors.initials: U
authors.lastname: Cucchini
authors.forename: Sabino
authors.initials: S
authors.lastname: Iliceto
authors.forename: Dragos
authors.initials: D
authors.lastname: Vinereanu
authors.forename: Luigi P
authors.initials: LP
authors.lastname: Badano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016279:Atrial Function, Left; D003971:Diastole; D019560:Echocardiography, Three-Dimensional; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000502:physiology*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D013599:Systole; D013997:Time Factors; D016277:Ventricular Function, Left; D055815:Young Adult