title: Medico-historical overview and histopathological comments about a hyalinizing trabecular tumor case of thyroid gland.
abstract: BACKGROUND
  Hyalinizing Trabecular Tumor (HTT) of the thyroid gland is a rare and controversial tumor, whose rigorous identification is extremely important due to the difficulty of establishing a correct diagnosis using only the routine histological stains (Hematoxylin-Eosin, Periodic Acid-Schiff, van Gieson, etc.). Using only usual stains, difficult problems of differential diagnosis arise. In this paper, we report a clinically unexpected case of HTT, the first in Romania, whose diagnosis has been established only by immunohistochemistry reactions.
  
  
  RESULTS
  In assessing a case with nodular goiter for diagnose purpose, we have found a nodule difficult to diagnose. We have been determined to appeal to some additional immunohistochemical techniques.
  
  
  CONCLUSIONS
  According to the immunohistochemistry reactions made, we found that particularly the Ki-67 immunohistochemical stain is obvious indispensable in establishing the diagnosis of HTT. We present also a medico-historical overview concerning some first descriptions of this rare entity. There are also mentioned some data regarding the behavior of this rare thyroid tumor.
authors.affiliation: Department of History of Medicine, Social Sciences and Humanism, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; cristianbarsu@yahoo.com.
authors.forename: Cristian
authors.initials: C
authors.lastname: Bârsu
authors.forename: Marina
authors.initials: M
authors.lastname: Bârsu
mesh_terms: D002449:Cell Aggregation; D002467:Cell Nucleus / Q000473:pathology; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism; D008875:Middle Aged; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*
chemical_list: D019394:Ki-67 Antigen