title: [Safety and tolerability of GLP-1 receptor agonists].
abstract: Glucagon-like peptide-1 receptor agonists (GLP-1ra) are a new group of drugs with a glucose-lowering action due to their incretin effect. The GLP-1 receptor is expressed in various human tissues, which could be related to the pleiotropic effects of human GLP-1, as well as to the adverse effects described in patients treated with GLP-1ra. The risk of hypoglycaemia is low, which is one of the main considerations in the safety of this family of compounds and is also important to patients with diabetes. The most frequent adverse effect is nausea, which usually occurs at the start of treatment and is transient in 20-60% of affected patients. This article also reviews the information available on antibody formation, the potential effect on the thyroid gland, and the controversial association between this group of drugs with pancreatitis and cancer.
authors.affiliation: Servicio de Endocrinología y Nutrición. Hospital e Instituto de Investigación Germans Trias i Pujol. Universitat Autònoma de Barcelona. Campus de can Ruti, Badalona, Barcelona, España.
authors.forename: Berta
authors.initials: B
authors.lastname: Soldevila
authors.affiliation: Servicio de Endocrinología y Nutrición. Hospital e Instituto de Investigación Germans Trias i Pujol. Universitat Autònoma de Barcelona. Campus de can Ruti, Badalona, Barcelona, España. Electronic address: mpuigd@gmail.com.
authors.forename: Manel
authors.initials: M
authors.lastname: Puig-Domingo
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D054795:Incretins / Q000009:adverse effects*; D009325:Nausea / Q000139:chemically induced; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D010195:Pancreatitis / Q000139:chemically induced; D013964:Thyroid Neoplasms / Q000139:chemically induced; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
chemical_list: D007004:Hypoglycemic Agents; D054795:Incretins; D000097789:Glucagon-Like Peptide-1 Receptor Agonists
keywords: Antibodies; Anticuerpos; Cancer; Cardiovascular; Cáncer; GLP-1; Gastrointestinal; Hipoglucemia; Hypoglycemia; Local reactions; Pancreatitis; Reacciones locales; Safety; Seguridad; Thyroid gland; Tiroides; Tolerability; Tolerancia