title: The small intestine microbiota, nutritional modulation and relevance for health.
abstract: The intestinal microbiota plays a profound role in human health and extensive research has been dedicated to identify microbiota aberrations that are associated with disease. Most of this work has been targeting the large intestine and fecal microbiota, while the small intestine microbiota may also have a profound impact on various aspects of the host's physiology, including immune, metabolic and endocrine functions. This review highlights the recent advances made in the study of the human small intestine microbiota. In addition, it describes recent human and animal studies that underpin the importance of this part of the intestine for health of the host organism.
authors.affiliation: TI Food and Nutrition, Wageningen, The Netherlands; Laboratory of Neurogastroenterology, Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland; Department of Industrial Biotechnology, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Sadat City, Egypt.
authors.forename: Sahar
authors.initials: S
authors.lastname: El Aidy
authors.affiliation: TI Food and Nutrition, Wageningen, The Netherlands; Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
authors.forename: Bartholomeus
authors.initials: B
authors.lastname: van den Bogert
authors.affiliation: TI Food and Nutrition, Wageningen, The Netherlands; Host-Microbe Interactomics Group, Wageningen University, Wageningen, The Netherlands; NIZO Food Research, Ede, The Netherlands. Electronic address: michiel.kleerebezem@wur.nl.
authors.forename: Michiel
authors.initials: M
authors.lastname: Kleerebezem
mesh_terms: D000581:Amidohydrolases / Q000378:metabolism; D000818:Animals; D006801:Humans; D007421:Intestine, Small / Q000382:microbiology*; D024821:Metabolic Syndrome / Q000382:microbiology; D064307:Microbiota; D019936:Probiotics
chemical_list: D000581:Amidohydrolases; C023154:choloylglycine hydrolase