title: Esophageal squamous cell carcinoma in six harbor seals (Phoca vitulina spp.).
abstract: Six cases of esophageal squamous cell carcinoma were identified in six captive adult Pacific (Phoca vitulina richardsii; n = 2) and Atlantic (Phoca vitulina concolor; n = 4) harbor seals. These seals presented with intermittent dysphagia, regurgitation, inappetence, and abnormal posturing. Common clinical pathology findings in these seals included azotemia, hyperproteinemia, hyperglobulinemia, and leukocytosis. Gastrointestinal endoscopy commonly revealed an ulcerated mass near the gastroesophageal junction. Each seal was euthanized (n = 3) due to poor prognosis, subsequently died while undergoing an anesthetic procedure (n = 2), or found dead (n = 1). The diagnosis of squamous cell carcinoma was confirmed via biopsy of esophageal mucosa during endoscopy or histopathologic examination of affected tissues after necropsy. On the basis of clinical and postmortem findings, esophageal squamous cell carcinoma should be considered as a differential diagnosis in aged harbor seals exhibiting clinical signs of regurgitation, decreased appetite or anorexia, vomiting, and/or abnormal posturing.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Flower
authors.forename: Kathryn C
authors.initials: KC
authors.lastname: Gamble
authors.forename: Michael
authors.initials: M
authors.lastname: Stone
authors.forename: Jeremiah A
authors.initials: JA
authors.lastname: Lyons
authors.forename: Rajanikanth J
authors.initials: RJ
authors.lastname: Maganti
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Tuomi
authors.forename: June E
authors.initials: JE
authors.lastname: Olds
authors.forename: Michele A
authors.initials: MA
authors.lastname: Sims
authors.forename: Phillip
authors.initials: P
authors.lastname: Gauger
authors.forename: Allison D
authors.initials: AD
authors.lastname: Tuttle
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000662:veterinary*; D004938:Esophageal Neoplasms / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D046049:Phoca