title: Anti-m antibody in solid tumors-two case reports.
abstract: Anti-M antibodies are usually of IgM, appear as cold agglutinins and are clinically insignificant. We are reporting two cases of anti-M in cases of solid tumors where the anti-M caused discrepancy in blood grouping, reacted in coombs phase of crossmatching. Anti-M in first case showed dosage effect. These antibodies can be clinical significant when detected in coombs phase, making M antigen negative coombs compatible unit transfusion imperative.
authors.affiliation: Department of Transfusion Medicine and Laboratory Services, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005 India.
authors.forename: Shiv Kumar
authors.initials: SK
authors.lastname: Soni
authors.affiliation: Department of Medical Oncology, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005 India.
authors.forename: Hari
authors.initials: H
authors.lastname: Goyal
authors.affiliation: Department of Transfusion Medicine and Laboratory Services, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005 India.
authors.forename: S K
authors.initials: SK
authors.lastname: Sood
authors.affiliation: Department of Transfusion Medicine and Laboratory Services, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005 India.
authors.forename: Rasika
authors.initials: R
authors.lastname: Setia
keywords: ABO discrepancy; Anti-M; Cross match incompatibility; Solid tumors