title: Postsynthetic modification of unprotected peptides via S-tritylation reaction.
abstract: Tritylation using trityl alcohol (Trt-OH) in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) is a convenient and efficient procedure that can offer S-protection of the Cys located in fully unprotected peptides. The procedure simply requires Trt-OH and HFIP to selectively promote S-tritylation in the presence of peptide nucleophilic functionalities.
authors.affiliation: Peptide Institute, Inc., Ibaraki, Osaka 567-0085, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Hajime
authors.initials: H
authors.lastname: Hibino
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nishiuchi
mesh_terms: D003545:Cysteine / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated
chemical_list: D003545:Cysteine; D010455:Peptides; D020005:Propanols; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated