title: A quartz crystal microbalance method to study the terminal functionalization of glycosaminoglycans.
abstract: We demonstrate the quartz crystal microbalance as a novel method to quantify the reaction yields and stability of the terminal conjugation of chemically complex molecules. Oxime ligation is identified as a facile, broadly applicable method for the reducing-end conjugation of glycosaminoglycans that overcomes the limited stability and yield of popular hydrazone ligation.
authors.affiliation: Université Grenoble Alpes, DCM, 38000 Grenoble, France.
authors.forename: Dhruv
authors.initials: D
authors.lastname: Thakar
authors.forename: Elisa
authors.initials: E
authors.lastname: Migliorini
authors.forename: Liliane
authors.initials: L
authors.lastname: Coche-Guerente
authors.forename: Rabia
authors.initials: R
authors.lastname: Sadir
authors.forename: Hugues
authors.initials: H
authors.lastname: Lortat-Jacob
authors.forename: Didier
authors.initials: D
authors.lastname: Boturyn
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet
authors.forename: Pierre
authors.initials: P
authors.lastname: Labbe
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Richter
mesh_terms: D006025:Glycosaminoglycans / Q000737:chemistry*; D006497:Heparan Sulfate / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry; D006835:Hydrazones / Q000737:chemistry; D010091:Oximes / Q000737:chemistry; D058525:Quartz Crystal Microbalance Techniques
chemical_list: D006025:Glycosaminoglycans; D006497:Heparan Sulfate; D006820:Hyaluronic Acid; D006835:Hydrazones; D010091:Oximes