title: A phosphine-catalyzed novel asymmetric [3+2] cycloaddition of C,N-Cyclic azomethine imines with δ-substituted allenoates.
abstract: Catalytic asymmetric [3+2] cycloadditions of C,N-cyclic azomethine imines with δ-substituted allenoates have been developed in the presence of (S)-Me-f-KetalPhos, affording functionalized tetrahydroquinoline frameworks in good yields with high diastereo- and good enantioselectivities under mild condition. The substrate scope has been also examined. This is the first time that δ-substituted allenoates have been applied as a δ,γ-C-C bond participated C2 synthon in asymmetric synthesis.
authors.affiliation: State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (P. R. China).
authors.forename: De
authors.initials: D
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Lei
authors.forename: Yin
authors.initials: Y
authors.lastname: Wei
authors.forename: Min
authors.initials: M
authors.lastname: Shi
keywords: azomethine imines; chiral phosphine; cycloaddition; enantioselectivity; substituted allenoates