title: No evidence of mammary tumor virus env gene-like sequences among Iranian women with breast cancer.
abstract: OBJECTIVE
  The mouse mammary tumor virus (MMTV) is the well-established etiological agent of mammary tumors in mice. A series of studies have implicated that a human murine mammary tumor virus-like virus occurs in human breast cancer, but it is unclear whether it has any causal role.
  
  
  METHODS
  The aim of the present study was to investigate the presence of MMTV env gene-like sequences in a group of Iranian women with or without breast cancer. A total of 65 breast cancer and 65 noncancerous breast specimens from the Department of Pathology of Tabriz University in East Azerbaijan, Iran, were analyzed by nested PCR.
  
  
  RESULTS
  All breast cancer and benign breast samples were negative for MMTV env gene-like DNA.
  
  
  CONCLUSIONS
  These results indicate that the MMTV env gene-like virus may not play a significant role in the etiology of breast cancer among Iranian women.
authors.affiliation: Department of Virology, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Ahangar Oskouee
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahmahmoodi
authors.forename: Somayeh
authors.initials: S
authors.lastname: Jalilvand
authors.forename: Mahmood
authors.initials: M
authors.lastname: Mahmoodi
authors.forename: Abed-Ali
authors.initials: AA
authors.lastname: Ziaee
authors.forename: Heidar Ali
authors.initials: HA
authors.lastname: Esmaeili
authors.forename: Talat
authors.initials: T
authors.lastname: Mokhtari-Azad
authors.forename: Maryam
authors.initials: M
authors.lastname: Yousefi
authors.forename: Yaghoob
authors.initials: Y
authors.lastname: Mollaei-Kandelous
authors.forename: Rakhshandeh
authors.initials: R
authors.lastname: Nategh
mesh_terms: D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000821:virology*; D005260:Female; D015752:Genes, env; D006801:Humans; D007492:Iran; D061986:MCF-7 Cells; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008875:Middle Aged; D016133:Polymerase Chain Reaction