title: [Design, synthesis and biological evaluation of novel 4-substituted-3-nitrobenzamide derivatives].
abstract: A series of novel 4-substituted-3-nitrobenzamide derivatives were designed and synthesized. The structures of the target compounds were confirmed with 1H NMR, 13C NMR, MS and element analysis. Anti-tumor activities against HCT-116, MDA-MB435 and HL-60 cell lines in vitro were evaluated by SRB assay. The results indicated most of the target compounds exhibited potent anti-tumor activity. Compound 4a showed the most potent inhibitory activities against three cancer cell lines with the GI50 values of 1.904-2.111 micromol x L(-1). Compounds 4g, 41-4n exhibited more potent inhibitory activities against MDA-MB435 and HL-60 cell lines with the GI50 values of 1.008-3.586 micromol x L(-1) and 1.993-3.778 micromol x L(-1), respectively. The structure-activity relationship of these compounds is discussed preliminarily.
authors.forename: Qi-Feng
authors.initials: QF
authors.lastname: Zhu
authors.forename: Yong-Xiang
authors.initials: YX
authors.lastname: Gong
authors.forename: Jin-Qing
authors.initials: JQ
authors.lastname: Zhong
authors.forename: Li-Fei
authors.initials: LF
authors.lastname: Liu
authors.forename: Xu-Fei
authors.initials: XF
authors.lastname: Li
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001549:Benzamides / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015195:Drug Design; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides