title: A new magnetic resonance imaging contrast agent loaded into poly(lacide-co-glycolide) nanoparticles for long-term detection of tumors.
abstract: The incorporation of a lipophilic Gd chelate (GdDO3A-C12) in biocompatible PLGA poly(D, L-lactide-co-glycolide) nanoparticles was explored as an approach to increase the relaxivity of contrast agents for magnetic resonance imaging. By nanoprecipitation, it was possible to obtain PEGylated gadolinium nanoparticles (mean diameter of 155 nm) with high Gd loading (1.1 × 10(4) Gd centers per nanoparticle). The corresponding GdDO3AC12 ⊂ NPs nanoparticles exhibited an enhanced relaxivity (up to sixfold greater than DOTAREM® at 40 MHz) because the nanoparticle framework constrained the lipophilic Gd chelate motion and favorably impacted the Gd chelate rotational correlation time. T1-weighted imaging at 3 T on phantoms showed enhanced contrast for the GdDO3AC12 ⊂ NPs. Importantly, Gd chelate leakage was almost nonexistent, which suggested that these GdDO3AC12 ⊂ NPs could be useful for long-term MRI detection.
authors.affiliation: Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR des Sciences Exactes et Naturelles, Bâtiment 18-Europol'Agro, BP1039, F-51687 Reims Cedex 2, France. Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR Pharmacie Reims, 51 rue Cognacq-Jay, F-51100 Reims, France.
authors.forename: G
authors.initials: G
authors.lastname: Rigaux
authors.forename: V G
authors.initials: VG
authors.lastname: Roullin
authors.forename: C
authors.initials: C
authors.lastname: Cadiou
authors.forename: C
authors.initials: C
authors.lastname: Portefaix
authors.forename: L
authors.initials: L
authors.lastname: Van Gulick
authors.forename: G
authors.initials: G
authors.lastname: Bœuf
authors.forename: M C
authors.initials: MC
authors.lastname: Andry
authors.forename: C
authors.initials: C
authors.lastname: Hoeffel
authors.forename: L
authors.initials: L
authors.lastname: Vander Elst
authors.forename: S
authors.initials: S
authors.lastname: Laurent
authors.forename: R
authors.initials: R
authors.lastname: Muller
authors.forename: M
authors.initials: M
authors.lastname: Molinari
authors.forename: F
authors.initials: F
authors.lastname: Chuburu
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000138:chemical synthesis*; D005682:Gadolinium / Q000737:chemistry; D005910:Glioma / Q000175:diagnosis*; D019344:Lactic Acid / Q000138:chemical synthesis; D008279:Magnetic Resonance Imaging / Q000379:methods*; D018625:Microscopy, Atomic Force; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D010316:Particle Size; D011100:Polyglycolic Acid / Q000138:chemical synthesis; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats
chemical_list: D003287:Contrast Media; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005682:Gadolinium