title: The short review on the studies of T cells receptors relate to type 1 diabetes.
abstract: Although type 1 diabetes (T1D) is a common autoimmune disease, and there have been many experimental and clinical researches on it, yet the exact mechanisms still remain unclear. What is the fact without doubt that T cells play an important role in the progress of T1D. Because the identification of T cells depends on the identification of MHC which binds the peptides of auto-antigens, the responses of T cells specific to this combination might make the T cell receptor (TCR) genes changed, especially the complementarity determining region 3 (CDR3) genes. According to this theory, it is possible to unclose the immune mechanisms of T1D from the changes of the specific TCR. This paper focuses on the current studies of TCR relative to T1D.
authors.affiliation: Clinical Laboratory, Affiliated Hospital of Jining Medical College, China. Electronic address: immunolife@126.com.
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Nursing Department, Affiliated Hospital of Jining Medical College, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Kong
authors.affiliation: Clinical Laboratory, Affiliated Hospital of Jining Medical College, China.
authors.forename: Xinke
authors.initials: X
authors.lastname: Chen
mesh_terms: D001324:Autoantigens / Q000097:blood; D022801:Complementarity Determining Regions / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000503:physiopathology; D018450:Disease Progression; D006801:Humans; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D001324:Autoantigens; D022801:Complementarity Determining Regions; D011948:Receptors, Antigen, T-Cell
keywords: Complementarity determining region 3; Short review; T cell receptor; Type 1 diabetes