title: Tear Osmolarity and Tear Function Changes in Patients with Acromegaly.
abstract: OBJECTIVE
  Since acromegaly is a disease with various systemic complications, it may also have ophthalmologic consequences. The aim of the current study was to compare the tear osmolarity and tear function changes in patients with acromegaly with those in healthy controls.
  
  
  METHODS
  Prospective, cross-sectional study.
  
  
  METHODS
  Fifty-nine consecutive patients with acromegaly and 62 age and gender matched healthy volunteers were enrolled in the study. Tear osmolarity measurement with TearLab Osmolarity System (Tearlab, San Diego, CA), tear film break-up time (TBUT) assessment, and the Schirmer test without anesthesia were performed in the same order in each group. Growth hormone (GH) and insulin like growth factor-1 (IGF1) levels were also determined in the study group.
  
  
  RESULTS
  The mean TBUT was lower in acromegalic patients (9.1 ± 3.6 seconds) than in healthy controls (10.7 ± 2.9 s) (p = 0.009). The difference between the two groups in tear osmolarity and Schirmer test results (p = 0.08 and p = 0.9, respectively) was not statistically different.
  
  
  CONCLUSIONS
  Acromegaly may a cause a decrease in TBUT in the affected patient. Preservation of normal tear osmolarity and normal Schirmer test results suggests that this might be due to effects on the meibomian glands.
authors.affiliation: Department of Ophthalmology, Istanbul University, Cerrahpasa Medical Faculty , Istanbul , Turkey .
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Arici
authors.forename: Esra
authors.initials: E
authors.lastname: Hatipoglu
authors.forename: Guzin
authors.initials: G
authors.lastname: Iskeleli
authors.forename: Pinar
authors.initials: P
authors.lastname: Sultan
authors.forename: Cansu
authors.initials: C
authors.lastname: Yuksel
authors.forename: Sadi
authors.initials: S
authors.lastname: Gundogdu
authors.forename: Pinar
authors.initials: P
authors.lastname: Kadioglu
mesh_terms: D000172:Acromegaly / Q000150:complications / Q000378:metabolism*; D000328:Adult; D003430:Cross-Sectional Studies; D015352:Dry Eye Syndromes / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008537:Meibomian Glands / Q000378:metabolism*; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D013666:Tears / Q000502:physiology*
keywords: Acromegaly; dry eye; tear function; tear osmolarity