title: Decreased expression of histone deacetylase 10 predicts poor prognosis of gastric cancer patients.
abstract: Aberrant expression of histone deacetylase (HDACs) was associated with carcinogenesis and progression of various tumors. However, the association of HDAC10 with clinical outcomes in gastric cancer patients is unclear. Thus, the objective of the current study was to evaluate the association of expression level of HDAC10 with clinicopathologic factors and prognosis of patients with gastric cancer. The expression level of HDAC10 in 179 paraffin-embedded gastric cancer tissue specimens was examined by immunohistochemistry (IHC). As a result, we found that expression of HDAC10 in gastric cancer was significantly decreased in gastric cancer tissues as compared with adjacent tissues (51.4% vs. 87.3%, P < 0.001). HDAC10 expression was significantly correlated with gender (P = 0.023), tumor size (P = 0.015), histological grade (P = 0.009), tumor invasion (P = 0.033), lymph node metastatic status (P = 0.019) and tumor stage (P = 0.004), but not correlated with age and lauren classification (all P > 0.05). Kaplan-Meier survival curves showed that the overall survival rate was significantly lower in the patients with low expression of HDAC10 compared with those patients with high HDAC10 (P < 0.001). Moreover, multivariate analysis revealed that HDAC10 expression was an independent prognostic factor for gastric cancer patients (P = 0.001). These results suggest that HDAC10 expression could see as a prognosis marker for gastric cancer patients.
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Ziliang
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Jiang
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiao
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Hu
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Oncology and Shanghai Key Laboratory of Pancreatic Diseases Shanghai Jiaotong University Affiliated Shanghai First People's Hospital Shanghai 200080, China.
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D015536:Down-Regulation; D005260:Female; D006655:Histone Deacetylases / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012307:Risk Factors; D012737:Sex Factors; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D013997:Time Factors; D046888:Tissue Array Analysis; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor; C447828:HDAC10 protein, human; D006655:Histone Deacetylases
keywords: Histone deacetylase 10; gastric cancer; immunohistochemistry; prognosis