title: Riluzole Ameliorates Harmaline-induced Tremor in Rat.
abstract: BACKGROUND
  Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat.
  
  
  METHODS
  Four groups of Wistar rats weighing 80-100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded.
  
  
  RESULTS
  The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor.
  
  
  CONCLUSIONS
  It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats.
authors.affiliation: School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
authors.forename: Fatemeh Rahimi
authors.initials: FR
authors.lastname: Shourmasti
authors.affiliation: School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
authors.forename: Iran
authors.initials: I
authors.lastname: Goudarzi
authors.affiliation: School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
authors.forename: Kataneh
authors.initials: K
authors.lastname: Abrari
authors.affiliation: School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
authors.forename: Mahmoud Elahdadi
authors.initials: ME
authors.lastname: Salmani
authors.affiliation: School of Biology, Damghan University, Damghan,Iran ; Institute of Biological Sciences, Damghan University, Damghan, Iran.
authors.forename: Taghi
authors.initials: T
authors.lastname: Laskarbolouki
keywords: Harmaline; Rat; Riluzole; Tremor