title: Improved understanding of pathogenesis from protein interactions in Mycobacterium tuberculosis.
abstract: Comprehensive mapping and analysis of protein-protein interactions provide not only systematic approaches for dissecting the infection and survival mechanisms of pathogens but also clues for discovering new antibacterial drug targets. Protein interaction data on Mycobacterium tuberculosis have rapidly accumulated over the past several years. This review summarizes the current progress of protein interaction studies on M. tuberculosis, the causative agent of tuberculosis. These efforts improve our knowledge on the stress response, signaling regulation, protein secretion and drug resistance of the bacteria. M. tuberculosis-host protein interaction studies, although still limited, have recently opened a new door for investigating the pathogenesis of the bacteria. Finally, this review discusses the importance of protein interaction data on identifying and screening new anti-tuberculosis targets and drugs, respectively.
authors.affiliation: Huazhong Agricultural University, Wuhan, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Cui
authors.forename: Zheng-Guo
authors.initials: ZG
authors.lastname: He
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000378:metabolism / Q000472:pathogenicity*; D060066:Protein Interaction Maps; D015398:Signal Transduction; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins
keywords: Mycobacterium tuberculosis; drug targets; pathogen–host interaction; protein–protein interaction; stress response