title: Plasma cardiac troponin I concentration and cardiac death in cats with hypertrophic cardiomyopathy.
abstract: BACKGROUND
  The use of cardiac biomarkers to assist in the diagnosis of occult and symptomatic hypertrophic cardiomyopathy (HCM) in cats has been established. There is limited data describing their prognostic utility in cats with HCM.
  
  
  OBJECTIVE
  Circulating concentrations of N-terminal B-type natriuretic peptide (NTproBNP) and cardiac troponin I (cTnI) predict cardiac death in cats with HCM.
  
  
  METHODS
  Forty-one cats diagnosed with HCM at a veterinary teaching hospital, between February 2010 and May 2011.
  
  
  METHODS
  Prospective investigational study. Plasma samples were collected from cats diagnosed with HCM and concentrations of NTproBNP and cTnI were analyzed at a commercial laboratory. Echocardiographic measurements from the day of blood sampling were recorded. Long-term outcome data were obtained. Associations with time to cardiac death were analyzed using Cox proportional hazards models.
  
  
  RESULTS
  When controlling for the presence/absence of heart failure and echocardiographic measures of left atrial size and function, cTnI > 0.7 ng/mL was independently associated with time to cardiac death. In univariable analysis, NTproBNP > 250 pmol/L was associated with cardiac death (P = .023), but this did not remain significant (P = .951) when controlling for the effect of clinical signs or left atrial size/function.
  
  
  CONCLUSIONS
  Plasma concentration of cTnI (cutoff >0.7 ng/mL) is a predictor of cardiac death in cats with HCM that is independent of the presence of heart failure or left atrial dilatation.
authors.affiliation: Royal Veterinary College, Hatfield, UK; Highcroft Veterinary Referrals, Bristol, UK.
authors.forename: K
authors.initials: K
authors.lastname: Borgeat
authors.forename: K
authors.initials: K
authors.lastname: Sherwood
authors.forename: J R
authors.initials: JR
authors.lastname: Payne
authors.forename: V
authors.initials: V
authors.lastname: Luis Fuentes
authors.forename: D J
authors.initials: DJ
authors.lastname: Connolly
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood / Q000000981:diagnostic imaging / Q000401:mortality / Q000662:veterinary*; D002371:Cat Diseases / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality; D002415:Cats / Q000097:blood; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016019:Survival Analysis; D019210:Troponin I / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Biomarkers; Cardiology; Cardiovascular; Monitoring; Outcome