title: Clinical features of 10 fetuses with prenatally diagnosed parvovirus b19 infection and fetal hydrops.
abstract: OBJECTIVE
  To evaluate the clinical features of fetuses with prenatally diagnosed parvovirus B19 infection and fetal hydrops.
  
  
  METHODS
  Parvovirus infection was diagnosed by PCR analysis of amniotic fluid or fetal blood. Fetal anemia was assessed by Doppler measurements of the middle cerebral artery peak systolic velocity (MCA-PSV) and confirmed by fetal blood. Intrauterine transfusions (IUT) were performed only if the MCA-PSV was > 1.5°MoM.
  
  
  RESULTS
  In our study population 10 cases of parvovirus infection which were associated with fetal hydrops were reviewed. The median gestational age at diagnosis was 21 (16.3-24.2) weeks. Five of our cases received IUT and four fetuses survived. The remaining five cases were managed conservatively and two fetuses survived.
  
  
  CONCLUSIONS
  The survival rate for parvovirus infection associated with fetal hydrops was 60%. MCA-PSV and IUT are useful for the management and treatment of fetal anemia due to parvovirus infection.
authors.affiliation: 1Department of Obstetrics and Gynecology, Chungbuk National University, Cheongju, Korea.
authors.forename: Kyu-Sang
authors.initials: KS
authors.lastname: Kyeong
authors.forename: Hye-Sung
authors.initials: HS
authors.lastname: Won
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Jae-Yoon
authors.initials: JY
authors.lastname: Shim
authors.forename: Pil Ryang
authors.initials: PR
authors.lastname: Lee
authors.forename: Ahm
authors.initials: A
authors.lastname: Kim
mesh_terms: D000653:Amniotic Fluid / Q000821:virology; D001783:Blood Flow Velocity; D001805:Blood Transfusion, Intrauterine; D015331:Cohort Studies; D016731:Erythema Infectiosum / Q000175:diagnosis* / Q000821:virology*; D005260:Female; D005312:Fetal Blood / Q000821:virology; D006801:Humans; D015160:Hydrops Fetalis / Q000821:virology*; D020768:Middle Cerebral Artery / Q000473:pathology; D016732:Parvovirus B19, Human; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D016896:Treatment Outcome; D018608:Ultrasonography, Doppler
keywords: fetal hydrops; intrauterine transfusion; middle cerebral artery peak systolic velocity; parvovirus B19