title: Total syntheses of menisporphine and daurioxoisoporphine C enabled by photoredox-catalyzed direct C-H arylation of isoquinoline with aryldiazonium salt.
abstract: Isoquinoline alkaloids are attractive natural products due to their diverse chemical structures as well as remarkable bioactivities. Herein, we report the concise total syntheses of two isoquinoline alkaloids, menisporphine and daurioxoisoporphine C, through a mild and efficient photoredox-catalyzed direct C-H arylation of isoquinoline core with aryldiazonium salt. This new strategy is complementary to the conventional isoquinoline synthesis and would provide us a useful means to achieve a more convergent and flexible approach to access diverse isoquinoline structures.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Lei
mesh_terms: D001688:Biological Products; D002384:Catalysis; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D012492:Salts / Q000737:chemistry*
chemical_list: D001688:Biological Products; D007546:Isoquinolines; D009861:Onium Compounds; D012492:Salts; C000596132:daurioxoisoporphine C; C039109:isoquinoline