title: The fusion of two worlds: non-coding RNAs and extracellular vesicles--diagnostic and therapeutic implications (Review).
abstract: The role of the extracellular non-coding RNAs, particularly microRNAs present in tumor-derived extravesicles, has been intensively exploited in human cancer as a promising tool for diagnostic and prognostic purposes. Current knowledge on exosomes shows an important role not only as vehicles in the intercellular communication, but the transfer of their content can specifically modulate the surrounding microenvironment, leading to tumor development and progression and affecting therapy response. Based on this, much effort has focused on understanding the mechanisms behind the biology of exosomes and their closely interaction with non-coding RNAs as an efficient tool in tumor diagnostic and therapy. Here we summarize the current knowledge on extracellular and exosomes-enclosed non-coding RNAs, and their importance as potential biomarkers and mediators of intercellular communication in tumor biology.
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Yukie
authors.initials: Y
authors.lastname: Sato-Kuwabara
authors.affiliation: Department of Cancer Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: Sonia A
authors.initials: SA
authors.lastname: Melo
authors.affiliation: International Research Center, AC Camargo Cancer Center, São Paulo, SP, Brazil.
authors.forename: Fernando A
authors.initials: FA
authors.lastname: Soares
authors.affiliation: Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
authors.forename: George A
authors.initials: GA
authors.lastname: Calin
mesh_terms: D000818:Animals; D055354:Exosomes / Q000473:pathology / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology; D025202:Molecular Diagnostic Techniques / Q000379:methods / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D022661:RNA, Untranslated / Q000502:physiology* / Q000627:therapeutic use
chemical_list: D035683:MicroRNAs; D022661:RNA, Untranslated