title: Single-nucleotide polymorphisms and DNA methylation markers associated with central obesity and regulation of body weight.
abstract: Visceral fat is strongly associated with the development of specific obesity-related metabolic alterations. Genetic and epigenetic mechanisms seem to be involved in the development of obesity and visceral adiposity. The aims of this review are to identify the single-nucleotide polymorphisms related to central obesity and to summarize the main findings on DNA methylation and obesity. A search of the MEDLINE database was conducted to identify genome-wide association studies, meta-analyses of genome-wide association studies, and gene-diet interaction studies related to central obesity, and, in addition, studies that analyzed DNA methylation in relation to body weight regulation. A total of 8 genome-wide association studies and 9 meta-analyses of genome-wide association studies reported numerous single-nucleotide polymorphisms to be associated with central obesity. Ten studies analyzed gene-diet interactions and central obesity, while 2 epigenome-wide association studies analyzed DNA methylation patterns and obesity. Nine studies investigated the relationship between DNA methylation and weight loss, excess body weight, or adiposity outcomes. Given the development of new sequencing and omics technologies, significantly more knowledge on genomics and epigenomics of obesity and body fat distribution will emerge in the near future.
authors.affiliation: Department of Nutrition, Food Science and Physiology, Centre for Nutrition Research, University of Navarra, Pamplona, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Goni
authors.forename: Fermín I
authors.initials: FI
authors.lastname: Milagro
authors.forename: Marta
authors.initials: M
authors.lastname: Cuervo
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martínez
mesh_terms: D001835:Body Weight / Q000235:genetics / Q000502:physiology; D019175:DNA Methylation; D005260:Female; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D056128:Obesity, Abdominal / Q000235:genetics* / Q000503:physiopathology*; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers
keywords: DNA methylation; EWAS; GWAS; epigenomics; gene-diet interaction; genomics; obesity; visceral fat