title: The Evaluation of Hydroxyethyl Starch (6% HES 130/0.4) Solution's Potential Preventive Effects on Coagulation Status in Women with Gynecologic Malignancies Using Rotation Thromboelastography.
abstract: OBJECTIVE
  The aim of this study was to determine the effects of in vitro hemodilution with 6% hydroxyethyl starch (HES) 130/0.4 solution on the coagulation status of women with gynecologic malignancies by using rotation thromboelastogram (ROTEM®).
  
  
  METHODS
  Twenty-two patients with gynecological tumors scheduled for anesthesia were enrolled. Blood samples were diluted by 20% with 6% HES (130/0.4) solution.
  
  
  RESULTS
  In the INTEM assay, clotting time (CT) (p<0.01) and clot formation time (CFT) (p<0.001) were significantly increased and maximum maximum clot formation (MCF) (p<0.001) was significantly decreased in HES hemodilution compared with the undiluted control samples. In the EXTEM assay, there was a similar significant increase in increase in CFT (p<0.01) and a decrease in maximum a decrease in MCF (p<0.01) in HES hemodilution when compared with control samples.
  
  
  CONCLUSIONS
  HES 130/0.4 solution causes significant hypocoagulable changes in the thromboelastographic profile of gynecologic cancer patients in vitro.
authors.affiliation: Eskişehir Osmangazi University Faculty of Medicine, Department of Hematology, Eskişehir, Turkey. E-ma-il: olga.akay@hotmail.com.
authors.forename: Meltem Olga
authors.initials: MO
authors.lastname: Akay
authors.forename: Ayten
authors.initials: A
authors.lastname: Bilir
authors.forename: Tufan
authors.initials: T
authors.lastname: Oge
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kuş
authors.forename: Fezan Sahin
authors.initials: FS
authors.lastname: Mutlu