title: Synthesis and evaluation of the anxiolytic activity of some phthalimide derivatives in mice model of anxiety.
abstract: The aim of the present study was to synthesis a series of phthalimides based on our previous works and examine their anxiolytic properties. Using a three steps process, phthalimides were prepared from the corresponding di-methyl phthalate derivatives. Phthalic anhydride was nitrated to produce 3-nitrophthalic acid. Ring closer of either 3-nitrophthalic acid or di-methyl phthalate with urea were carried out in reflux condition. Final compounds were prepared by base catalyzed condensation of 4-methylbenzoyl chloride, benzoyl chloride and benzyl chloride with the resulting imides. From the tested compounds, only N-benzoyl 3-nitro-phthalimide was shown to produce anxiolytic activity by increasing the number of entries and time spent in open arms at 10 mg/kg.
authors.affiliation: Department of Medicinal Chemistry, Isfahan University of Medical Sciences, Isfahan, Iran. ; Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Hassanzadeh
authors.affiliation: Department of Pharmacology, Isfahan Pharmaceutical Sciences Research Center, Iran. ; Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rabbani
authors.affiliation: Department of Medicinal Chemistry, Isfahan University of Medical Sciences, Isfahan, Iran. ; Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ghadam Ali
authors.initials: GA
authors.lastname: Khodarahmi
authors.affiliation: Department of Medicinal Chemistry, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Moosavi
keywords: 3-Nitrophthalimide; Anxiety; Elevated plus-maze; Phthalimide