title: Adding a sexual dysfunction domain to UPOINT system improves association with symptoms in women with interstitial cystitis and bladder pain syndrome.
abstract: OBJECTIVE
  To examine whether adding a sexual dysfunction domain to urinary, psychosocial, organ specific, infection, neurologic or systemic, and tenderness (UPOINT) system improves the association with interstitial cystitis and bladder pain syndrome (IC-BPS) symptom severity due to a high prevalence of sexual dysfunction in women.
  
  
  METHODS
  A total of 90 Chinese women with IC-BPS were prospectively collected and classified in each domain of the UPOINT system. Symptom severity was measured using the Interstitial Cystitis Symptom Index (ICSI). The sexual function was evaluated using the Female Sexual Function Index (FSFI). Clinically relevant associations were calculated.
  
  
  RESULTS
  The percentage of patients positive for each domain were 90 of 90 (100%), 33 of 90 (37%), 88 of 90 (98%), 21 of 90 (23%), 36 of 90 (40%), 38 of 90 (42%), 62 of 90 (69%) for the urinary, psychosocial, organ specific, infection, neurologic or systemic, tenderness, and sexual dysfunction, respectively. There were significant associations between the number of domains and ICSI (Spearman r = 0.386; P <.05) and FSFI (Spearman r = 0.614; P <.001) scores. After adding a sexual dysfunction domain to create a modified UPOINTS system, the association between the number of domains and symptom severity was improved (correlation coefficient r changed from 0.386 to 0.572; P <.001). The presence of sexual dysfunction had a significant impact on the ICSI scores (P = .032), pain scores (P = .042), and quality of life index scores (P = .035). Significantly reduced FSFI scores were found in patients who had positive psychosocial, organ specific, and tenderness domains (all P values <.05).
  
  
  CONCLUSIONS
  Our study demonstrated sexual dysfunction was an important component of IC-BPS phenotype, and adding a sexual dysfunction domain to the UPOINT system improved the association with IC-BPS symptom severity.
authors.affiliation: Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China.
authors.forename: Bolong
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Rehabilitation Medicine, The Third Affiliated Hospital and Lingnan Hospital of the Sun Yat-Sen University, Guangzhou, China.
authors.forename: Minzhi
authors.initials: M
authors.lastname: Su
authors.affiliation: Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China.
authors.forename: Hailun
authors.initials: H
authors.lastname: Zhan
authors.affiliation: Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China.
authors.forename: Wenbiao
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Urology, The Third Affiliated Hospital of the Sun Yat-Sen University, Guangzhou, China. Electronic address: Xiangfuzhou1962@163.com.
authors.forename: Xiangfu
authors.initials: X
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D018856:Cystitis, Interstitial / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D011788:Quality of Life; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis* / Q000453:epidemiology* / Q000523:psychology; D018434:Sickness Impact Profile; D018709:Statistics, Nonparametric; D014555:Urination Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000517:prevention & control; D014563:Urodynamics