title: External validation of the national healthcare safety network risk models for surgical site infections in total hip and knee replacements.
abstract: BACKGROUND
  The National Healthcare Safety Network surgical site infections risk models for hip (HPRO) and knee (KPRO) replacement are intended for case-mix adjustment when reporting surgical site infection rates across institutions, but they are not validated in external data sets.
  
  
  OBJECTIVE
  To evaluate the validity of HPRO and KPRO risk models and improvement in risk prediction with inclusion of information on morbid obesity and diabetes mellitus.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  A single-center cohort of 21,941 hip and knee replacement procedures performed between 2002 and 2009.
  
  
  METHODS
  Discriminative ability was assessed using the concordance statistic (C statistic). Calibration was assessed using the Hosmer-Lemeshow goodness-of-fit tests.
  
  
  RESULTS
  The discrimination of HPRO was good, with a C statistic of 0.695 for surgical site infections and 0.749 for prosthetic joint infections. The discrimination of KPRO was worse than that of HPRO, with a C statistic of 0.592 for surgical site infections and 0.675 for prosthetic joint infections. Adding morbid obesity and diabetes mellitus to the HPRO and KPRO risk models modestly improved discrimination. There was no significant evidence of miscalibration based on the Hosmer-Lemeshow tests, but calibration of HPRO models appeared to be better than that of the KPRO models.
  
  
  CONCLUSIONS
  HPRO performed better than the KPRO in predicting surgical site infections after hip and knee replacements. Both fared well in predicting prosthetic joint infections.
authors.affiliation: Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
authors.forename: Laura W
authors.initials: LW
authors.lastname: Lewallen
authors.forename: Hilal
authors.initials: H
authors.lastname: Maradit Kremers
authors.forename: Brian D
authors.initials: BD
authors.lastname: Lahr
authors.forename: Tad M
authors.initials: TM
authors.lastname: Mabry
authors.forename: James M
authors.initials: JM
authors.lastname: Steckelberg
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Berry
authors.forename: Arlen D
authors.initials: AD
authors.lastname: Hanssen
authors.forename: Elie F
authors.initials: EF
authors.lastname: Berbari
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Osmon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000706:statistics & numerical data*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000706:statistics & numerical data*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D016459:Prosthesis-Related Infections / Q000453:epidemiology*; D012086:Reoperation; D012189:Retrospective Studies; D020379:Risk Adjustment / Q000379:methods*; D013530:Surgical Wound Infection / Q000453:epidemiology*; D014481:United States / Q000453:epidemiology