title: Chemoselective silyl transfer in the Mukaiyama aldol reaction promoted by super silyl Lewis acid.
abstract: In the silyl Lewis acid-promoted Mukaiyama aldol reaction, the steric and electronic properties of the silyl group on the silyl Lewis acid influence the reaction mechanism and product distribution. When super silyl triflates such as (TMS)3SiOTf and (TES)3SiOTf are used as Lewis acids, the silyl group of the silyl enol ether chemoselectively transfers to the product. The mechanistic details have been investigated using density functional theory (DFT) calculations.
authors.affiliation: Molecular Catalyst Research Center, Chubu University, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan. sai@isc.chubu.ac.jp hyamamoto@isc.chubu.ac.jp.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sai
authors.forename: Matsujiro
authors.initials: M
authors.lastname: Akakura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto