title: Adapted Finnegan scoring list for observation of anti-depressant exposed infants.
abstract: OBJECTIVE
  The Finnegan scoring list (FSL) is widely used to screen for poor neonatal adaptation in infants exposed to anti-depressants in utero. However, the large number of FSL-items and differential weighing of each item is time consuming. The aim of this study was to shorten and simplify the FSL yet preserving its clinimetric properties.
  
  
  METHODS
  This observational study examined infants exposed to an anti-depressant during pregnancy admitted for at least 72 h on a maternity ward. Trained nurses completed the FSL three times daily. Items for the adapted FSL were selected through forward analysis whereby the number of selected items was based on the area under the curve (AUC). Internal validity was assessed by cross-validation.
  
  
  RESULTS
  183 infants met the inclusion criteria. By forward analysis eight equally-weighed items resulted in an AUC of 0.91. In cross-validation, the mean AUC was 0.89 for 8 items. This adapted FSL had a sensitivity of 97.7% and specificity of 37.0% and a sensitivity of 41.9% and specificity of 86.2% regarding a cut-off of, respectively, 1 and 2.
  
  
  CONCLUSIONS
  An adapted FSL with eight equally-weighed items has acceptable clinimetric properties and can serve as an easy to apply screening tool in infants exposed to anti-depressants during pregnancy.
authors.affiliation: a Department of Paediatrics , Psychiatry Obstetrics Paediatrics Expert Centre Sint Lucas Andreas Hospital , Amsterdam , The Netherlands .
authors.forename: Noera
authors.initials: N
authors.lastname: Kieviet
authors.affiliation: a Department of Paediatrics , Psychiatry Obstetrics Paediatrics Expert Centre Sint Lucas Andreas Hospital , Amsterdam , The Netherlands .
authors.forename: Mariëtte
authors.initials: M
authors.lastname: van Ravenhorst
authors.affiliation: a Department of Paediatrics , Psychiatry Obstetrics Paediatrics Expert Centre Sint Lucas Andreas Hospital , Amsterdam , The Netherlands .
authors.forename: Koert M
authors.initials: KM
authors.lastname: Dolman
authors.affiliation: b Department of Epidemiology and Biostatistics , VU University Medical Centre , Amsterdam , The Netherlands .
authors.forename: Peter M
authors.initials: PM
authors.lastname: van de Ven
authors.affiliation: c Department of Gynaecology and Obstetrics .
authors.forename: Marion
authors.initials: M
authors.lastname: Heres
authors.affiliation: a Department of Paediatrics , Psychiatry Obstetrics Paediatrics Expert Centre Sint Lucas Andreas Hospital , Amsterdam , The Netherlands .
authors.forename: Hanneke
authors.initials: H
authors.lastname: Wennink
authors.affiliation: d Department of Psychiatry , Psychiatry Obstetrics Paediatrics Expert Centre Sint Lucas Andreas Hospital , Amsterdam , The Netherlands , and.|e Department of Psychiatry , VU University Medical Centre , Amsterdam , The Netherlands.
authors.forename: Adriaan
authors.initials: A
authors.lastname: Honig
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects*; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis; D002493:Central Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis; D005183:Failure to Thrive / Q000175:diagnosis*; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008431:Maternal-Fetal Exchange; D009426:Netherlands; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D015203:Reproducibility of Results; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000175:diagnosis; D012680:Sensitivity and Specificity
chemical_list: D000928:Antidepressive Agents
keywords: Depression; SSRI; neonatal abstinence syndrome; neonatal withdrawal; poor neonatal adaptation