title: Overview of the "epigenetic end points in toxicologic pathology and relevance to human health" session of the 2014 Society Of Toxicologic Pathology Annual Symposium.
abstract: The theme of the Society of Toxicologic Pathology 2014 Annual Symposium was "Translational Pathology: Relevance of Toxicologic Pathology to Human Health." The 5th session focused on epigenetic end points in biology, toxicity, and carcinogenicity, and how those end points are relevant to human exposures. This overview highlights the various presentations in this session, discussing integration of epigenetics end points in toxicologic pathology studies, investigating the role of epigenetics in product safety assessment, epigenetic changes in cancers, methodologies to detect them, and potential therapies, chromatin remodeling in development and disease, and epigenomics and the microbiome. The purpose of this overview is to discuss the application of epigenetics to toxicologic pathology and its utility in preclinical or mechanistic based safety, efficacy, and carcinogenicity studies.
authors.affiliation: In Vivo Animal Core, Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA hoenerho@med.umich.edu.
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Hoenerhoff
authors.affiliation: Celgene Corporation, Summit, New Jersey, USA.
authors.forename: James
authors.initials: J
authors.lastname: Hartke
mesh_terms: D000818:Animals; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D064420:Drug-Related Side Effects and Adverse Reactions; D023381:Endpoint Determination; D044127:Epigenesis, Genetic; D057890:Epigenomics / Q000379:methods*; D006801:Humans; D010336:Pathology / Q000379:methods*; D061214:Patient Safety; D014116:Toxicology / Q000379:methods*
keywords: carcinogenesis; epigenetics; histone deacetylation; histone modification; methylation; microbiome.; no adverse effect level; safety assessment; toxicology