title: Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology.
abstract: Carcinoma arising in microglandular adenosis (MGACA) is an extremely rare subtype of breast carcinoma. In this study, clinicopathological analysis of MGACA from 11 Chinese patients was conducted. Microscopically, all cases showed a spectrum of structure and glandular proliferations ranging from microglandular adenosis (MGA) to atypical MGA (AMGA) to MGACA. Carcinoma components were composed of high grade ductal carcinoma in situ (DCIS) in 1 case and invasive carcinoma in 10 cases. Invasive carcinomas were grade 3 in 10 tumors and grade 2 in 1. Invasive components in 5 of 10 cases were composed of invasive carcinoma of no special type (NST), and 1 case showed partially acinic cell differentiation. In 5 cases, invasive components were mixed of NST and matrix-producing carcinoma (MPC). All epitheliums in 11 cases were triple negative (ER-, PR-, HER2-), and diffuse positive for CK and S-100 protein. No myoepithelial cells were demonstrable from MGA to invasive components with immunohistochemical staining for P63 and calponin. PAS or reticulin stain showed the presence of a basement membrane around glands in MGA, AMGA, DCIS, and its absence in invasive components. Follow-up time ranged from 10 to 64 months. One patient developed a lung metastasis 24 months after surgery, 10 patients have been alive without recurrence. Our study revealed that MGACA is a distinct subset of breast carcinoma, with triple negative phenotype, high grade nuclear and variable morphology. Despite histopathologic and immunohistochemical features usually associated with a poor prognosis, MGACA seems to have a relatively favorable outcome.
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhong
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Bi
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Yu
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Yufan
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Ruohong
authors.initials: R
authors.lastname: Shui
authors.affiliation: Department of Pathology, Cancer Center, Fudan University Shanghai, China ; Department of Oncology, Fudan University Shanghai, China.
authors.forename: Wentao
authors.initials: W
authors.lastname: Yang
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D049109:Cell Proliferation; D002681:China; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D008875:Middle Aged; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D010641:Phenotype; D013997:Time Factors; D016896:Treatment Outcome; D064726:Triple Negative Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000556:secondary / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor
keywords: Breast carcinoma; matrix-producing carcinoma; microglandular adenosis; morphology; triple-negative phenotype