title: Association between Interleukin-6 gene -572G>C polymorphism and coronary heart disease.
abstract: The association of the Interleukin 6 (IL-6) -572G>C polymorphism and risk of coronary heart disease (CHD) have been implicated in a large number of investigations, but the results remain debatable. This meta-analysis was performed to provide more compelling evidence for the connection between the IL-6 -572G>C polymorphism and CHD risk. Studies eligible for this meta-analysis were identified through electronic search of PubMed, EMBASE, and CNKI. The fixed effects model was performed to summarize an odds ratio (OR) with 95 % confidence interval (CI). The meta-analysis of 3,985 patients and 7,153 controls from 17 studies showed that the CC genotype carriers had 0.84-fold lower risk of developing CHD when compared with the carriers with the GC+GG genotypes (OR(CC vs. GC+GG) = 0.84; 95% CI = 0.75-0.95; P = 0.414; I(2) = 3.5%). The decreased risk of CHD was also found in Asians (OR = 0.87; 95% CI = 0.77-0.98; P = 0.227; I(2) = 22.7%) and Caucasians (OR = 0.60; 95% CI = 0.40-0.92; P = 0.958; I(2) = 0) under the same genetic comparison. The results of our meta-analysis revealed that the IL-6 -572G>C polymorphism may be linked with risk of CHD in a protective model.
authors.affiliation: Department of Cardiology, The Second Hospital of Jilin University, Ziqiang Street, Changchun, 130041, China, drchunlisong@163.com.
authors.forename: Chunli
authors.initials: C
authors.lastname: Song
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Donghui
authors.initials: D
authors.lastname: Yang
authors.forename: Hongying
authors.initials: H
authors.lastname: Diao
authors.forename: Liyan
authors.initials: L
authors.lastname: Zhao
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Yu
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Guo
authors.forename: Jichang
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiangen
authors.initials: J
authors.lastname: Liu
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zaho
authors.forename: Xiaohao
authors.initials: X
authors.lastname: Zhang
mesh_terms: D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6