title: Exploring phosphatidylinositol 5-phosphate 4-kinase function.
abstract: The family of phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) is emerging from a comparative backwater in inositide signalling into the mainstream, as is their substrate, phosphatidylinositol 5-phosphate (PI5P). Here we review some of the key questions about the PI5P4Ks, their localisation, interaction, and regulation and also we summarise our current understanding of how PI5P is synthesised and what its cellular functions might be. Finally, some of the evidence for the involvement of PI5P4Ks in pathology is discussed.
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Bulley
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK.
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Clarke
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK.
authors.forename: Alaa
authors.initials: A
authors.lastname: Droubi
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK.
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Giudici
authors.affiliation: Department of Pharmacology, Tennis Court Road, Cambridge, CB2 1PD, UK. Electronic address: rfi20@cam.ac.uk.
authors.forename: Robin F
authors.initials: RF
authors.lastname: Irvine
mesh_terms: D000818:Animals; D006801:Humans; D018129:Phosphatidylinositol Phosphates / Q000235:genetics* / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018129:Phosphatidylinositol Phosphates; C113567:phosphatidylinositol 5-phosphate; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase
keywords: Inositide; Kinase; Phosphatidylinositol; Phosphatidylinositol 5-Phosphate4-kinase; Phosphatidylinositol 5-phosphate