title: Orthostatic hypertension in children and adolescents with postural tachycardia syndrome.
abstract: OBJECTIVE
  We described a heterogenous group of children disabled by postural tachycardia syndrome (POTS) and evident orthostatic hypertension (OHT).
  
  
  METHODS
  Twenty patients met the diagnostic criteria for POTS + OHT. Their clinical characteristics were compared with those in 76 patients with POTS alone and 20 healthy age-matched controls. Multivariate logistic regression analysis was used to identify independent risk factors for POTS + OHT.
  
  
  RESULTS
  Supine systolic blood pressure (SBP) was lower in the POTS + OHT group than in the POTS group (p < 0.05). Compared with the POTS group, the POTS + OHT group showed markedly increased upright SBP, upright heart rate (HR) and HR changes (p < 0.05). Headache was more common in the POTS + OHT group than in the POTS group (p < 0.05). Logistic regression analysis revealed that low supine SBP and headache were independent risk factors for OHT in POTS patients.
  
  
  CONCLUSIONS
  Headache and low supine SBP were the main clinical characteristics of a novel syndrome of POTS associated with OHT.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Qingyou
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Jiawei
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Xie
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China junbaodu1@126.com.
authors.forename: Junbao
authors.initials: J
authors.lastname: Du
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D002648:Child; D002681:China; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D015999:Multivariate Analysis; D054972:Postural Orthostatic Tachycardia Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology*; D012044:Regression Analysis; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D018667:Tilt-Table Test
keywords: autonomic nervous system; children; orthostatic hypertension; tachycardia