title: A retrospective review of a tertiary Hospital's isolation and de-isolation policy for suspected pulmonary tuberculosis.
abstract: BACKGROUND
  Effective protocols for the isolation and de-isolation of patients with suspected pulmonary tuberculosis (PTB) are essential determinants of health-care costs. Early de-isolation needs to be balanced with the need to prevent nosocomial transmission of PTB. The aim of our study was to evaluate the efficiency of our hospital's current protocol for isolating and de-isolating patients with suspected PTB, in particular assessing the timeliness to de-isolation of patients with AFB smear negative respiratory samples.
  
  
  METHODS
  We retrospectively reviewed 121 patients with suspected PTB who were admitted to our hospital's isolation ward. We analyzed the time spent in isolation, the total number of respiratory samples that were collected for each patient and the time taken from collection of the first respiratory sample to release of the result of third respiratory sample for acid-fast bacilli (AFB) smear. We also calculated the direct cost of isolation for each patient.
  
  
  RESULTS
  The mean and median number of AFB smears for each patient was three. Thirty percent of patients had four or more AFB smears taken and 20% were de-isolated before the results of three negative AFB smears were obtained. The mean duration of isolation was significantly shorter in patients who had fewer than three negative AFB smears compared to those who had three or more negative AFB smears (three days vs. five days, p <0.01). The mean cost in patients who were de-isolated before three negative smears were obtained was USD 947 compared to USD 1,636 in those were only de-isolated after three negative AFB smears (p <0.01).
  
  
  CONCLUSIONS
  Our study suggests that our institution's current infection control policy for the isolation of patients with suspected PTB is fairly satisfactory, but may need to be tightened further to prevent true cases of PTB being de-isolated prematurely. However, there may be instances when patients could potentially be de-isolated more quickly without risk to others, thus saving on the use of limited resources and costs to patients.
authors.affiliation: Department of Infectious Diseases, Singapore General Hospital, 20 College Road, Singapore 169856, Singapore. shirin.kalimuddin@sgh.com.sg.
authors.forename: Shirin
authors.initials: S
authors.lastname: Kalimuddin
authors.forename: Jeanne M M
authors.initials: JM
authors.lastname: Tan
authors.forename: Ban Hock
authors.initials: BH
authors.lastname: Tan
authors.forename: Jenny G H
authors.initials: JG
authors.lastname: Low
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003428:Cross Infection / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016134:Organizational Policy; D010351:Patient Discharge; D010356:Patient Isolation; D012189:Retrospective Studies; D062606:Tertiary Care Centers / Q000458:organization & administration; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*