title: Acquired factor v inhibitor developing after treatment with dabigatran etexilate methanesulfonate: a case report and review of the literature.
abstract: A 90-year-old man presented with subcutaneous ecchymoses. He had been under treatment with dabigatran etexilate methanesulfonate (DEM). Prolonged APTT and decreased PT was developed 2 months after the start of DEM, more prolonged 6 months later. DEM was discontinued, the coagulopathy did not improve. Factor V activity was decreased, along with appearance of coagulation factor V inhibitor (FVI). He did not have antiphospholipid syndrome or malignancy. He was diagnosed as having acquired FVI caused by DEM. Steroid pulse therapy was effective. There have been 74 reported cases of AFVI induced by drug treatment, but none after treatment with DEM.
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Sekiguchi
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Yoshikawa
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Shimada
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Imai
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Wakabayashi
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Sugimoto
authors.affiliation: Department of Laboratory Medicine, Juntendo University Urayasu Hospital, Urayasu, Chiba Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Nakamura
authors.affiliation: Department of Laboratory Medicine, Juntendo University Urayasu Hospital, Urayasu, Chiba Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sawada
authors.affiliation: Department of Cardiology, Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ichinose
authors.affiliation: Department of Cardiology, Juntendo University Urayasu Hospital, Urayasu, Chiba Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Ozaki
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Komatsu
authors.affiliation: Department of Hematology, Juntendo University Urayasu Hospital, 1-1, 2-Chome, Tomioka, Urayasu, Chiba Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Noguchi
keywords: Acquired factor V inhibitor; Coagulation factor V deficiency; Dabigatran etexilate methanesulfonate; Steroid pulse