title: The molecular machinery of neurotransmitter release (Nobel lecture).
abstract: The most important property of synaptic transmission is its speed, which is crucial for the overall workings of the brain. In his Nobel Lecture, T. C. Südhof explains how the synaptic vesicle and the plasma membrane undergo rapid fusion during neurotransmitter release and how this process is spatially organized, such that opening of Ca(2+) -channels allows rapid translation of the entering Ca(2+) signal into a fusion event.
authors.affiliation: Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Lorry Lokey SIM1 Building 07-535 Room G1021, 265 Campus Drive, Stanford University School of Medicine, CA 94305 (USA).
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Südhof
mesh_terms: D002118:Calcium / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion; D009473:Neuronal Plasticity; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009613:Nobel Prize; D050600:SNARE Proteins / Q000378:metabolism; D050857:Synaptotagmins / Q000378:metabolism
chemical_list: D018377:Neurotransmitter Agents; D050600:SNARE Proteins; D050857:Synaptotagmins; D002118:Calcium
keywords: hormone secretion; intracellular signaling; membrane fusion; synaptic plasticity; vesicular transport