title: Etiologic, environmental and inherited risk factors in sarcomas.
abstract: Sarcomas are a rare group of mesenchymal tumors affecting a younger population. The etiology remains unknown in most cases. Environmental factors that increase sarcoma risk include radiation exposure and chemical carcinogens. Several familial cancer syndromes confer sarcoma predisposition, such as the Li-Fraumeni Syndrome (LFS). In this increasingly genomic focussed era of medicine, it will be clinically important to understand the genetic basis of sarcoma risk.
authors.affiliation: The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia; Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.
authors.forename: David M
authors.initials: DM
authors.lastname: Thomas
authors.forename: Mandy L
authors.initials: ML
authors.lastname: Ballinger
mesh_terms: D000818:Animals; D004777:Environment; D020022:Genetic Predisposition to Disease; D006801:Humans; D016864:Li-Fraumeni Syndrome / Q000235:genetics; D012509:Sarcoma / Q000209:etiology* / Q000235:genetics
keywords: familial cancer syndrome; genetic sarcoma risk; sarcoma etiology