title: Medical advances in the treatment of postpartum hemorrhage.
abstract: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide. Recent advances in the management of severe bleeding for trauma patients may provide insight into PPH management, but must be applied with caution considering the significant differences between trauma and obstetric patients. In this review, we summarized evidence for current management strategies for patients with major obstetric hemorrhage, including (1) rapid laboratory assessment of coagulopathy, (2) early transfusion of plasma and high plasma-to-red blood cell transfusion ratios in massive PPH, and (3) use of tranexamic acid and fibrinogen concentrates in the setting of PPH complicated by coagulopathy.
authors.affiliation: From the *Pole d'Anesthésie-Réanimation, Academic Hospital Lille, Lille, France; †Pole d'Hématologie Transfusion, Academic Hospital Lille, Lille, France; ‡Université Lille Nord de France, Lille, France; §Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; ∥Department of Anesthesia, Stanford University School of Medicine, Stanford, California; and ¶Duke Transfusion Service, Department of Pathology, DUMC, Durham, North Carolina.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Ducloy-Bouthors
authors.forename: Sophie
authors.initials: S
authors.lastname: Susen
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Wong
authors.forename: Alex
authors.initials: A
authors.lastname: Butwick
authors.forename: Benoit
authors.initials: B
authors.lastname: Vallet
authors.forename: Evelyn
authors.initials: E
authors.lastname: Lockhart
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000209:etiology; D001803:Blood Transfusion / Q000379:methods; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy*; D011247:Pregnancy