title: FGFR1 as a novel prognostic and predictive biomarker in squamous cell cancers of the lung and the head and neck area.
abstract: FGFR1 amplification is a genomic aberration recently identified in various types of cancer. Especially squamous cell carcinomas of the lung and the head and neck show this genetic alteration in high frequencies. In these cancers FGFR1 is not only a therapeutic target but does also serve as a biomarker that correlates with parameters of worse outcome. However, since FGFR1 amplification does not always correlate with high protein expression defining the best predictive biomarker for a FGFR1 targeted therapy is of great importance.
authors.affiliation: 1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: von Mässenhausen
authors.affiliation: 1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Alina
authors.initials: A
authors.lastname: Franzen
authors.affiliation: 1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Lynn
authors.initials: L
authors.lastname: Heasley
authors.affiliation: 1 Department of Prostate Cancer Research, Institute of Pathology, University Hospital of Bonn, Germany ; 2 Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Sven
authors.initials: S
authors.lastname: Perner
keywords: FGFR1; biomarker; head and neck cancer; lung cancer; therapeutic target