title: [Pseudohypobicarbonatemia in a patient with a kappa IgA monoclonal gammapathy].
abstract: Paraprotein interferences assays are known but rather unusual in clinical chemistry.we here report a paraprotein interference with a bicarbonate assay in a IgA kappa-type myeloma patient. Serum bicarbonate level was assessed by the enzymatic method of a multiparametric chemistry analyzer (Advia 1800, Siemens) as well as a specific electrode assay on a blood gas analyzer (GEM 4000, IL). Paraprotein interference with the enzymatic assay was evidenced by an abnomally low bicarbonate level measured by the enzymatic method in contrast with usual levels obtained by using the gas analyzer and with the clinical status of the patient. Therefore, gammapathy has to be taken into consideration when interpreting biological data.
authors.affiliation: Département de biochimie et pharmaco-toxicologie, Hôpital de la Cavale Blanche, CHRU, Brest, France.
authors.forename: Ismaïl
authors.initials: I
authors.lastname: Lazzouni
authors.affiliation: Service de néphrologie, Hôpital de la Cavale Blanche, CHRU, Brest, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Cornec
authors.affiliation: Département de biochimie et pharmaco-toxicologie, Hôpital de la Cavale Blanche, CHRU, Brest, France, EA 4685, Laboratoire de neurosciences de Brest, Faculté de médecine, Brest, France.
authors.forename: Ahmed
authors.initials: A
authors.lastname: Meskar
authors.affiliation: Département de biochimie et pharmaco-toxicologie, Hôpital de la Cavale Blanche, CHRU, Brest, France.
authors.forename: Danièle
authors.initials: D
authors.lastname: Lucas
authors.affiliation: Département de biochimie et pharmaco-toxicologie, Hôpital de la Cavale Blanche, CHRU, Brest, France, EA 4685, Laboratoire de neurosciences de Brest, Faculté de médecine, Brest, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Kerspern
authors.affiliation: Département de biochimie et pharmaco-toxicologie, Hôpital de la Cavale Blanche, CHRU, Brest, France, EA 4685, Laboratoire de neurosciences de Brest, Faculté de médecine, Brest, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Carré
mesh_terms: D000368:Aged; D001639:Bicarbonates / Q000097:blood*; D001774:Blood Chemical Analysis; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D010265:Paraproteinemias / Q000097:blood* / Q000276:immunology; D014883:Water-Electrolyte Imbalance / Q000097:blood*
chemical_list: D001639:Bicarbonates; D007070:Immunoglobulin A
keywords: bicarbonates; immunoglobulin A; interferences