title: Metabolic syndrome in IgA glomerulonephritis.
abstract: OBJECTIVE
  Metabolic syndrome (MetS) may have an independent impact on the development of chronic kidney disease. This study examines the prevalence of MetS in subjects with IgA glomerulonephritis (IgAGN) and its impact on disease progression in a retrospective fashion.
  
  
  METHODS
  Altogether, 174 subjects (104 males) were examined 11 years (first visit) after IgAGN diagnosis and again after 16 years (second visit; 144 subjects responded). Different glomerular filtration markers were utilized. The MetS criteria by Alberti et al. [Circulation 2009;120:1640-1645] were applied, in which the presence of any three of five risk factors (elevated waist circumference, triglycerides, glucose, existence of hypertension, or reduced high-density lipoprotein cholesterol) constitutes the diagnosis.
  
  
  RESULTS
  The prevalence of MetS at the first visit was 39%, corresponding to that of the general Finnish population. In univariate analyses, MetS was significantly associated with the progression of IgAGN at the second visit. However, in multivariate analyses, the existence of MetS was not a significant prognostic determinant.
  
  
  CONCLUSIONS
  The number of subjects with MetS among IgAGN patients and the general population is equal in Finland. MetS does not seem to be an independent prognostic variable.
authors.affiliation: School of Medicine, University of Tampere, Savonlinna, Finland.
authors.forename: Kati
authors.initials: K
authors.lastname: Kaartinen
authors.affiliation: School of Medicine, University of Tampere, Savonlinna, Finland ; Department of Internal Medicine, Tampere University Hospital, Tampere, Savonlinna, Finland.
authors.forename: Jaana
authors.initials: J
authors.lastname: Syrjänen
authors.affiliation: School of Medicine, University of Tampere, Savonlinna, Finland ; Department of Internal Medicine, Tampere University Hospital, Tampere, Savonlinna, Finland.
authors.forename: Ilkka
authors.initials: I
authors.lastname: Pörsti
authors.affiliation: Department of Laboratory Medicine, Central Hospital of Savonlinna, Savonlinna, Finland.
authors.forename: Aimo
authors.initials: A
authors.lastname: Harmoinen
authors.affiliation: School of Health Sciences, University of Tampere, Savonlinna, Finland.
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.affiliation: School of Medicine, University of Tampere, Savonlinna, Finland ; Department of Internal Medicine, Tampere University Hospital, Tampere, Savonlinna, Finland.
authors.forename: Jukka
authors.initials: J
authors.lastname: Mustonen
keywords: Creatinine; Cystatin-C; Estimated glomerular filtration rate; IgA glomerulonephritis; Metabolic syndrome