title: Glycemic responses to intermittent hepatic inflow occlusion in living liver donors.
abstract: The occurrence of glycemic disturbances has been described for patients undergoing intermittent hepatic inflow occlusion (IHIO) for tumor removal. However, the glycemic responses to IHIO in living liver donors are unknown. This study investigated the glycemic response to IHIO in these patients and examined the association between this procedure and the occurrence of hyperglycemia (blood glucose > 180 mg/dL). The data from 154 living donors were retrospectively reviewed. The decision to perform IHIO was made on the basis of the extent of bleeding that occurred during parenchymal dissection. One round of IHIO consisted of 15 minutes of clamping and 5 minutes of unclamping the hepatic artery and portal vein. Blood glucose concentrations were measured at predetermined time points, including the start and end of IHIO. Repeated hyperglycemic episodes occurred after unclamping. The mean maximum intraoperative blood glucose concentration was greater in donors who underwent ≥3 rounds of IHIO versus those who underwent 1 or 2 rounds (169 ± 30 versus 149 ± 31 mg/dL, P = 0.005). The incidence of intraoperative hyperglycemia was also greater in donors who underwent ≥3 rounds of IHIO versus those who underwent 1 or 2 rounds (38.7% versus 7.7%, odds ratio = 7.1, 95% confidence interval = 2.5-20.4, P < 0.001). Donors who did not undergo IHIO and those who underwent 1 or 2 rounds of IHIO exhibited similar maximum glucose concentrations and similar incidence rates of hyperglycemia. In conclusion, IHIO induced repeated hyperglycemic responses in living donors, and donors who underwent ≥3 rounds of IHIO were more likely to experience intraoperative hyperglycemia. These results provide additional information on the risks and benefits of IHIO in living donors.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Sangbin
authors.initials: S
authors.lastname: Han
authors.forename: Justin
authors.initials: J
authors.lastname: Sangwook Ko
authors.forename: Sang-Man
authors.initials: SM
authors.lastname: Jin
authors.forename: Jong
authors.initials: J
authors.lastname: Man Kim
authors.forename: Soo Joo
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jae-Won
authors.initials: JW
authors.lastname: Joh
authors.forename: Yang
authors.initials: Y
authors.lastname: Hoon Chung
authors.forename: Suk-Koo
authors.initials: SK
authors.lastname: Lee
authors.forename: Mi Sook
authors.initials: MS
authors.lastname: Gwak
authors.forename: Gaabsoo
authors.initials: G
authors.lastname: Kim
mesh_terms: D000328:Adult; D001706:Biopsy; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006498:Hepatectomy; D006499:Hepatic Artery / Q000473:pathology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology*; D007432:Intraoperative Period; D008099:Liver / Q000473:pathology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D016017:Odds Ratio; D011169:Portal Vein / Q000473:pathology; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D001786:Blood Glucose