title: Chondroitinase: A promising therapeutic enzyme.
abstract: Even after 20 years of granting orphan status for chondroitinase by US FDA, there is no visible outcome in terms of clinical use. The reasons are many. One of them could be lack of awareness regarding the biological application of the enzyme. The biological activity of chondroitinase is due to its ability to act on chondroitin sulfate proteoglycans (CSPGs). CSPGs are needed for normal functioning of the body. An increase or decrease in the level of CSPGs results in various pathological conditions. Chondroitinase is useful in conditions where there is an increase in the level of CSPGs, namely spinal cord injury, vitreous attachment and cancer. Over the last decade, various animal studies showed that chondroitinase could be a good drug candidate. Research focusing on developing a suitable carrier system for delivering chondroitinase needs to be carried out so that pharmacological activity observed in vitro and preclinical studies could be translated to clinical use. Further studies on distribution of chondroitinase as well need to be focused so that chondroitinase with desired attributes could be discovered. The present review article discusses about various biological applications of chondroitinase, drug delivery systems to deliver the enzyme and distribution of chondroitinase among microbes.
authors.affiliation: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Kasinathan
authors.affiliation: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Subrahmanyam M
authors.initials: SM
authors.lastname: Volety
authors.affiliation: a Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
authors.forename: Venkata Rao
authors.initials: VR
authors.lastname: Josyula
mesh_terms: D000818:Animals; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism; D002810:Chondroitinases and Chondroitin Lyases / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D013119:Spinal Cord Injuries / Q000188:drug therapy
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D002810:Chondroitinases and Chondroitin Lyases
keywords: Chondroitin hydrolase; chondroitin sulfate lyase; mucopolysaccharide; spinal cord injury; vitrectomy