title: Joint parametric reconstruction and motion correction framework for dynamic PET data.
abstract: In this paper we propose a novel algorithm for jointly performing data based motion correction and direct parametric reconstruction of dynamic PET data. We derive a closed form update for the penalised likelihood maximisation which greatly enhances the algorithm's computational efficiency for practical use. Our algorithm achieves sub-voxel motion correction residual with noisy data in the simulation-based validation and reduces the bias of the direct estimation of the kinetic parameter of interest. A preliminary evaluation on clinical brain data using [18F]Choline shows improved contrast for regions of high activity. The proposed method is based on a data-driven kinetic modelling method and is directly applicable to reversible and irreversible PET tracers, covering a range of clinical applications.
authors.forename: Jieqing
authors.initials: J
authors.lastname: Jiao
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bousse
authors.forename: Kris
authors.initials: K
authors.lastname: Thielemans
authors.forename: Pawel
authors.initials: P
authors.lastname: Markiewicz
authors.forename: Ninon
authors.initials: N
authors.lastname: Burgos
authors.forename: David
authors.initials: D
authors.lastname: Atkinson
authors.forename: Simon
authors.initials: S
authors.lastname: Arridge
authors.forename: Brian F
authors.initials: BF
authors.lastname: Hutton
authors.forename: Sébastien
authors.initials: S
authors.lastname: Ourselin
mesh_terms: D016477:Artifacts; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008954:Models, Biological; D009038:Motion; D049268:Positron-Emission Tomography / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: C516370:fluoromethylcholine; D002794:Choline