title: Higher doses of (+)MK-801 (dizocilpine) induced mortality and procedural but not cognitive deficits in delayed testing in the active place avoidance with reversal on the Carousel.
abstract: Schizophrenia is a devastating disorder affecting 1 % of the world's population. An important role in the study of this disease is played by animal models. Since there is evidence that acute psychotic episodes can have consequences on later cognitive functioning, the present study has investigated the effects of a single systemic application of higher doses of (+)MK-801 (3 mg/kg and 5 mg/kg) to adult male Long-Evans rats from the Institute's breeding colony on delayed testing in the active place avoidance task with reversal on the Carousel (a rotating arena). Besides significant mortality due to the injections, a disruption of procedural functions in active place avoidance, after the dose 5 mg/kg was observed. It was concluded that Long-Evans rats from our breeding colony do not represent a suitable biomodel for studying the effects of single high-dose NMDA antagonists.
authors.affiliation: Institute of Physiology CAS, Prague, Czech Republic. stuchlik@biomed.cas.cz.
authors.forename: V
authors.initials: V
authors.lastname: Lobellová
authors.forename: E
authors.initials: E
authors.lastname: Brichtová
authors.forename: T
authors.initials: T
authors.lastname: Petrásek
authors.forename: K
authors.initials: K
authors.lastname: Valeš
authors.forename: A
authors.initials: A
authors.lastname: Stuchlík
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003072:Cognition Disorders / Q000139:chemically induced* / Q000523:psychology*; D016291:Dizocilpine Maleate / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects; D011605:Psychoses, Substance-Induced / Q000523:psychology; D051381:Rats; D020318:Rats, Long-Evans; D012193:Reversal Learning / Q000187:drug effects*
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate