title: Squamous cell carcinoma and eosinophilia in a long-term course of pansclerotic morphea.
abstract: Pansclerotic morphea is a rare subtype of localised scleroderma. Very few cases have been reported in the literature. This case discusses a young man with a 15-year history of pansclerotic morphea, illustrating the clinical course and complications of this disease. Notably, recurrent squamous cell carcinomas with several high-risk features and frequent cellulitis were the basis of many admissions. As often seen with this disease, autoimmune markers were negative. However, marked eosinophilia was noted late in the course. Furthermore, this disease is quite resistant to treatment. Immunosuppressive therapy thus far has perhaps slowed the progression, although not cured the disease in this patient.
authors.affiliation: University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Inderjote
authors.initials: I
authors.lastname: Grewal
authors.affiliation: Department of Rheumatology, Ochsner Medical Center, New Orleans, Louisiana, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Khan
authors.affiliation: Department of Rheumatology, Ochsner Medical Center, New Orleans, Louisiana, USA.
authors.forename: William
authors.initials: W
authors.lastname: Davis
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D002481:Cellulitis / Q000150:complications; D018450:Disease Progression; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D005542:Forearm; D006801:Humans; D007866:Leg / Q000098:blood supply; D008297:Male; D009364:Neoplasm Recurrence, Local; D012594:Scleroderma, Localized / Q000150:complications* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D013717:Tenosynovitis / Q000150:complications; D020246:Venous Thrombosis / Q000150:complications