title: Lipid Profile and Electrolyte Composition in Diabetic Rats Treated With Leaf Extract of Musa sapientum.
abstract: Diabetes mellitus affects lipid levels resulting in diabetic dyslipidemia as well as electrolyte loss from the body. Musa sapientum has been reported to possess antidiabetic properties. This study assessed the lipid profile and electrolyte composition in alloxan-induced diabetic rats treated with methanol leaf extract of M. sapientum (cMEMSL). Diabetes was induced with alloxan (120 mg/kg i.p.). Seventy-five male albino rats were divided into 5 groups of 15 rats each. Group 1 was control; groups 2-5 were made diabetic and treated with 0.2 ml 0.9% NaCl, cMEMSL (250 mg/kg and 500 mg/kg), and glibenclamide (5 mg/kg), respectively, for 14 days. Blood samples were obtained from the retro orbital sinus after light anesthesia from 5 animals in each group on days 2, 7, and 14 for lipids and electrolyte analysis. Lipid profile of diabetic treated (cMEMSL and glibenclamide) animals showed significant reduction (p < .05) in total cholesterol, triglyceride, and low density lipoprotein (LDL) levels. The high density lipoprotein (HDL) level in the treatment groups increased significantly (p < .05) compared with diabetic untreated. Sodium, potassium, and phosphate ions significantly increased in all diabetic treatment groups while chloride ion significantly decreased compared with diabetic untreated. There was no significant difference in calcium and bicarbonate ion concentration in all the groups. This study has showed additional properties of Musa sapientum to include its ability to restore electrolyte balance, reduce cholesterol, triglyceride, LDL, and increase the HDL levels in diabetic animals.
authors.affiliation: a Department of Physiology, University of Ibadan , Ibadan, Nigeria.
authors.forename: E O
authors.initials: EO
authors.lastname: Adewoye
authors.affiliation: a Department of Physiology, University of Ibadan , Ibadan, Nigeria.
authors.forename: A O
authors.initials: AO
authors.lastname: Ige
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004573:Electrolytes / Q000097:blood*; D007477:Ions / Q000097:blood; D008297:Male; D028521:Musa; D010710:Phosphates / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D011188:Potassium / Q000097:blood; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D014280:Triglycerides / Q000097:blood*; D014882:Water-Electrolyte Balance
chemical_list: D001639:Bicarbonates; D002712:Chlorides; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004573:Electrolytes; D007477:Ions; D010710:Phosphates; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D012964:Sodium; D011188:Potassium; D002118:Calcium
keywords: Diabetes mellitus; Musa sapientum; dyslipidemia; electrolytes alteration