title: Regulation of lncRNA expression.
abstract: Long non-coding RNAs (lncRNAs) are series of transcripts with important biological functions. Various diseases have been associated with aberrant expression of lncRNAs and the related dysregulation of mRNAs. In this review, we highlight the mechanisms of dynamic lncRNA expression. The chromatin state contributes to the low and specific expression of lncRNAs. The transcription of non-coding RNA genes is regulated by many core transcription factors applied to protein-coding genes. However, specific DNA sequences may allow their unsynchronized transcription with their location-associated mRNAs. Additionally, there are multiple mechanisms involved in the post-transcriptional regulation of lncRNAs. Among these, microRNAs might have indispensible regulatory effects on lncRNAs, based on recent discoveries.
authors.affiliation: Center for Drug Research and Development, Zhujiang Hospital, Southern Medical University, Zhujiang, China.
authors.forename: Zhuomin
authors.initials: Z
authors.lastname: Wu
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Houliang
authors.initials: H
authors.lastname: Deng
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Bohong
authors.initials: B
authors.lastname: Cen
authors.forename: Aimin
authors.initials: A
authors.lastname: Ji
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid; D061785:Transcription Initiation, Genetic
chemical_list: D062085:RNA, Long Noncoding