title: Malignant lymphatic and hematopoietic neoplasms mortality in Serbia, 1991-2010: a joinpoint regression analysis.
abstract: BACKGROUND
  Limited data on mortality from malignant lymphatic and hematopoietic neoplasms have been published for Serbia.
  
  
  METHODS
  The study covered population of Serbia during the 1991-2010 period. Mortality trends were assessed using the joinpoint regression analysis.
  
  
  RESULTS
  Trend for overall death rates from malignant lymphoid and haematopoietic neoplasms significantly decreased: by -2.16% per year from 1991 through 1998, and then significantly increased by +2.20% per year for the 1998-2010 period. The growth during the entire period was on average +0.8% per year (95% CI 0.3 to 1.3). Mortality was higher among males than among females in all age groups. According to the comparability test, mortality trends from malignant lymphoid and haematopoietic neoplasms in men and women were parallel (final selected model failed to reject parallelism, P = 0.232). Among younger Serbian population (0-44 years old) in both sexes: trends significantly declined in males for the entire period, while in females 15-44 years of age mortality rates significantly declined only from 2003 onwards. Mortality trend significantly increased in elderly in both genders (by +1.7% in males and +1.5% in females in the 60-69 age group, and +3.8% in males and +3.6% in females in the 70+ age group). According to the comparability test, mortality trend for Hodgkin's lymphoma differed significantly from mortality trends for all other types of malignant lymphoid and haematopoietic neoplasms (P<0.05).
  
  
  CONCLUSIONS
  Unfavourable mortality trend in Serbia requires targeted intervention for risk factors control, early diagnosis and modern therapy.
authors.affiliation: Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Milena
authors.initials: M
authors.lastname: Ilic
authors.affiliation: Department of Epidemiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
authors.forename: Irena
authors.initials: I
authors.lastname: Ilic
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D019337:Hematologic Neoplasms / Q000401:mortality*; D006689:Hodgkin Disease / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008223:Lymphoma / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D055771:Serbia; D012737:Sex Factors; D044465:White People; D055815:Young Adult