title: Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative.
abstract: A tetra-ortho-chloro substituted azobenzene unit was incorporated into a photoswitchable tethered ligand for ionotropic glutamate receptors. This compound confers the modified protein with the unusual optical responses of the substituted azo scaffold permitting channel opening with yellow and red light and channel closing with blue light.
authors.affiliation: Department of Chemistry, University of Toronto, Toronto M5S 3H6, Canada. awoolley@chem.utoronto.ca.
authors.forename: A
authors.initials: A
authors.lastname: Rullo
authors.forename: A
authors.initials: A
authors.lastname: Reiner
authors.forename: A
authors.initials: A
authors.lastname: Reiter
authors.forename: D
authors.initials: D
authors.lastname: Trauner
authors.forename: E Y
authors.initials: EY
authors.lastname: Isacoff
authors.forename: G A
authors.initials: GA
authors.lastname: Woolley
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D057809:HEK293 Cells; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*; D008024:Ligands; D015394:Molecular Structure; D055620:Optical Phenomena; D017470:Receptors, Glutamate / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*
chemical_list: D001391:Azo Compounds; D007473:Ion Channels; D008024:Ligands; D017470:Receptors, Glutamate; C009850:azobenzene