title: Modulation of IL-37 expression by triptolide and triptonide in THP-1 cells.
abstract: IL-37 is an anti-inflammatory cytokine that was only recently identified, and it is highly expressed in tissues from patients with inflammatory and autoimmune diseases. Inflammatory cytokines and inflammatory stimuli can induce the upregulation of IL-37. However, it has not been reported whether anti-inflammatory medications induce the expression of IL-37. In this work, we uncovered, for the first time, that two main bioactive components, triptolide and triptonide, from the herb Tripterygium wilfordii Hook f. (TwHF), which possess anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors. Overall, our research demonstrated, for the first time, that anti-inflammatory active components (triptolide and triptonide) upregulated the expression of IL-37 most likely via activation of the ERK1/2 and p38 MAPK pathways.Cellular & Molecular Immunology advance online publication, 6 October 2014; doi:10.1038/cmi.2014.92.
authors.affiliation: Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China.
authors.forename: Lingge
authors.initials: L
authors.lastname: He
authors.affiliation: Department of Clinical Immunology, Guangdong Medical College, Dongguan, China.
authors.forename: Zhuangyan
authors.initials: Z
authors.lastname: Liang
authors.affiliation: Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China.
authors.forename: Fuqian
authors.initials: F
authors.lastname: Zhao
authors.affiliation: Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China.
authors.forename: Lifei
authors.initials: L
authors.lastname: Peng
authors.affiliation: 1] Key Laboratory for Medical Molecular Diagnostic of Guangdong Province, Guangdong Medical College, Dongguan, China [2] Department of Clinical Immunology, Guangdong Medical College, Dongguan, China.
authors.forename: Zhangquan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000276:immunology*; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000276:immunology; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D010616:Phenanthrenes / Q000737:chemistry / Q000494:pharmacology*; D029757:Tripterygium / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D004852:Epoxy Compounds; C508587:IL37 protein, human; D007375:Interleukin-1; D010616:Phenanthrenes; D014315:Triterpenes; C001899:triptolide; C084079:triptonide; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D048051:p38 Mitogen-Activated Protein Kinases