title: [The laboratory medicine as a foundation for personalized medicine. The application of biochips in medicine].
abstract: The development and application of biochips provide possibility to drastically transform laboratory medicine and to implement studies of arrays of biomarkers realizing approaches and concepts of personalized medicine. The main areas of application of microbiochips in laboratory medicine such as laboratory diagnostic, classification and prognosis of course of diseases, analysis of mechanisms of biologic processes are considered. The identification of inherent mutations in human genome is considered as perspective direction. These mutations cause various pathology and first of all oncologic diseases responsible for biotransformation of pharmaceuticals applied in chemotherapy of tumors in particular and also simultaneous identification of various infection agents (viruses, microorganisms, fungi, etc.) and their antibiotic-resistant forms. The role of biochips as a tool is demonstrated in genetic studies, technologies of genetic typing, large-scale international projects of studies of genome-wide screening of associations (GWAS).
authors.forename: S N
authors.initials: SN
authors.lastname: Scherbo
authors.forename: D S
authors.initials: DS
authors.lastname: Scherbo
mesh_terms: D013677:Medical Laboratory Science / Q000379:methods*; D046228:Microarray Analysis; D057285:Precision Medicine / Q000379:methods*