title: Synthesis and biology of cyclic imine toxins, an emerging class of potent, globally distributed marine toxins.
abstract: From a small group of exotic compounds isolated only two decades ago, Cyclic Imine (CI) toxins have become a major class of marine toxins with global distribution. Their distinct chemical structure, biological mechanism of action, and intricate chemistry ensures that CI toxins will continue to be the subject of fascinating fundamental studies in the broad fields of chemistry, chemical biology, and toxicology. The worldwide occurrence of potent CI toxins in marine environments, their accumulation in shellfish, and chemical stability are important considerations in assessing risk factors for human health. This review article aims to provide an account of chemistry, biology, and toxicology of CI toxins from their discovery to the present day.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA.
authors.forename: Craig E
authors.initials: CE
authors.lastname: Stivala
authors.forename: Evelyne
authors.initials: E
authors.lastname: Benoit
authors.forename: Rómulo
authors.initials: R
authors.lastname: Aráoz
authors.forename: Denis
authors.initials: D
authors.lastname: Servent
authors.forename: Alexei
authors.initials: A
authors.lastname: Novikov
authors.forename: Jordi
authors.initials: J
authors.lastname: Molgó
authors.forename: Armen
authors.initials: A
authors.lastname: Zakarian
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004777:Environment; D006801:Humans; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D012758:Shellfish
chemical_list: D001688:Biological Products; D007097:Imines; D008387:Marine Toxins