title: Prediction of fetal outcome without intrauterine intervention using a cardiovascular profile score: a systematic review and meta-analysis.
abstract: OBJECTIVE
  With the help of fetal echocardiography, cardiovascular profile score (CVPS) can be evaluated. However, no general agreement has been recognized on the prediction value of CVPS on fetal adverse outcome.
  
  
  METHODS
  Literature review has identified up to Nov 2012 in the databases. Meta-analysis was performed in a fixed/random-effect model using Revman 5.1.1 and Meta-disc 1.4. The differences among different cut-offs were measured by STATA 11.0.
  
  
  RESULTS
  Result from seven studies reported an outcome in favor of significant lower CVPS in fetus of adverse outcome with std. mean difference of -1.17 (95% CI = -1.78, -0.55). The overall performance of CVPS ≤ 6 prediction adverse outcome evaluated as area under the summary receiver operating characteristic curves (AUC) was 0.8777. The AUC of CVPS ≤ 7 was 0.8728 and the AUC of CVPS ≤ 8 was 0.7207. However, the result indicated the performance of CVPS ≤ 6 prediction adverse outcome had a statistical significance comparing to other two cut-offs.
  
  
  CONCLUSIONS
  Analysis has proven the CVPS is a credible index for predicting fetal adverse outcome. And once CVPS decreased at eight, the patient should be observed carefully. With the CVPS dropped at seven, treatment is demanded immediately while some cases suffer irreversible cardiac dysfunction.
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|d West China Medical School , and.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Li
authors.affiliation: e West China Stomatology School, Sichuan University , Chengdu , Sichuan , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Fang
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|c Program for Changjiang Scholars and Innovative Research Team in University, West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .
authors.forename: Kaiyu
authors.initials: K
authors.lastname: Zhou
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|d West China Medical School , and.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|c Program for Changjiang Scholars and Innovative Research Team in University, West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .
authors.forename: Yimin
authors.initials: Y
authors.lastname: Hua
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|c Program for Changjiang Scholars and Innovative Research Team in University, West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Shi
authors.affiliation: a Department of Pediatric Cardiovascular Disease , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|b Ministry of Education Key Laboratory of Women and Children's Diseases and Birth Defects , West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .|c Program for Changjiang Scholars and Innovative Research Team in University, West China Second University Hospital, Sichuan University , Chengdu , Sichuan , China .
authors.forename: Dezhi
authors.initials: D
authors.lastname: Mu
mesh_terms: D002318:Cardiovascular Diseases / Q000175:diagnosis*; D003661:Decision Support Techniques; D004452:Echocardiography; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D005318:Fetal Heart / Q000000981:diagnostic imaging; D006801:Humans; D015233:Models, Statistical; D011247:Pregnancy; D011379:Prognosis; D016216:Ultrasonography, Prenatal
keywords: CVPS; echocardiography; fetal diagnosis; meta-analysis; prognosis