title: Antimicrobial γ-AApeptides (WO2013112548): a patent evaluation.
abstract: The patent application WO2013112548 claims a new class of peptidomimetics - γ-AApeptides with potent and broad-spectrum antimicrobial activity. These γ-AApeptides are active against both Gram-positive and Gram-negative bacteria, including medicinally relevant drug-resistant pathogens. They are believed to exert bactericidal function by mimicking the membrane disruption mechanism of host-defense peptides. As such, they may provide an alternative approach for antimicrobial development combating antibiotic resistance.
authors.affiliation: University of South Florida, Department of Chemistry , 4202 E. Fowler Ave, Tampa, FL 33620 , USA +1 813 974 9506 ; +1 813 974 3203 ; jianfengcai@usf.edu.
authors.forename: Peng
authors.initials: P
authors.lastname: Teng
authors.forename: Haifan
authors.initials: H
authors.lastname: Wu
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D015195:Drug Design; D004345:Drug Industry / Q000331:legislation & jurisprudence*; D024881:Drug Resistance, Bacterial; D006801:Humans; D015394:Molecular Structure; D010330:Patents as Topic; D057786:Peptidomimetics / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D057786:Peptidomimetics
keywords: Gram-positive and Gram-negative; antimicrobial; membrane disruption; peptidomimetics; γ-AApeptides