title: Worse in-hospital outcomes in patients with transient ischemic attack in association with acute kidney injury: analysis of nationwide in-patient sample.
abstract: OBJECTIVE
  The effect of acute kidney injury (AKI) on outcomes of transient ischemic attack (TIA) is largely unknown. We wanted to determine the impact of AKI on the outcomes of patients admitted with TIA.
  
  
  METHODS
  Data from all adult patients admitted to the U.S. hospitals between 2005 and 2011 with a primary discharge diagnosis of TIA and secondary diagnosis of AKI were included, using the nationwide in-patient dataset. The association of AKI with TIA-related mortality and discharge outcomes was analyzed after adjusting for potential confounders using logistic regression analysis.
  
  
  RESULTS
  Of the 1,173,340 patients admitted with TIA, 45,974 (3.8%) had AKI. Dialysis was required in 29 (0.06%) patients. TIA patients with AKI had higher rates of moderate-to-severe disability (21.2 vs. 13.7%, p ≤ 0.0001), and in-hospital mortality (0.6 vs. 0.1%, p ≤ 0.0001) compared with those without AKI. After adjusting for age, sex, and potential confounders; TIA patients with AKI had higher odds of moderate-to-severe disability [OR 1.3, 95% CI 1.2-1.4, p < 0.0001] and death (OR 4.2, 95% CI 3.0-6.1, p < 0.0001).
  
  
  CONCLUSIONS
  AKI in patients with TIA is associated with significantly higher rates of moderate-to-severe disability at discharge and in-hospital mortality compared with those without AKI.
authors.affiliation: Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Fahad
authors.initials: F
authors.lastname: Saeed
authors.forename: Malik M
authors.initials: MM
authors.lastname: Adil
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Malik
authors.forename: Mushtaq H
authors.initials: MH
authors.lastname: Qureshi
authors.forename: Fadi
authors.initials: F
authors.lastname: Nahab
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000453:epidemiology* / Q000401:mortality*; D000368:Aged; D005260:Female; D017052:Hospital Mortality; D006760:Hospitalization; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications / Q000453:epidemiology* / Q000401:mortality*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D010351:Patient Discharge; D012044:Regression Analysis; D006435:Renal Dialysis / Q000706:statistics & numerical data; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States