title: Post-stroke cognitive impairment: epidemiology, mechanisms and management.
abstract: Post-stroke cognitive impairment occurs frequently in the patients with stroke. The prevalence of post-stroke cognitive impairment ranges from 20% to 80%, which varies for the difference between the countries, the races, and the diagnostic criteria. The risk of post-stroke cognitive impairment is related to both the demographic factors like age, education and occupation and vascular factors. The underlying mechanisms of post-stroke cognitive impairment are not known in detail. However, the neuroanatomical lesions caused by the stroke on strategic areas such as the hippocampus and the white matter lesions (WMLs), the cerebral microbleeds (CMBs) due to the small cerebrovascular diseases and the mixed AD with stroke, alone or in combination, contribute to the pathogenesis of post-stroke cognitive impairment. The treatment of post-stroke cognitive impairment may benefit not only from the anti-dementia drugs, but also the manage measures on cerebrovascular diseases. In this review, we will describe the epidemiological features and the mechanisms of post-stroke cognitive impairment, and discuss the promising management strategies for these patients.
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 2 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China ; 3 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210000, China.
authors.forename: Jia-Hao
authors.initials: JH
authors.lastname: Sun
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 2 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China ; 3 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210000, China.
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
authors.affiliation: 1 Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266071, China ; 2 College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, China ; 3 Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing 210000, China.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
keywords: Post-stroke cognitive impairment; mechanism; prevalence; risk factor; treatment