title: Anti-N-methyl-D-aspartate receptor and anti-ribosomal-P autoantibodies contribute to cognitive dysfunction in systemic lupus erythematosus.
abstract: OBJECTIVE
  Autoantibodies against N-methyl-D-aspartate receptor (anti-NMDAR) and ribosomal-P (anti-P) antigens are potential pathogenic factors in the frequently observed diffuse brain dysfunctions in patients with systemic lupus erythematosus (SLE). Although studies have been conducted in this area, the role of anti-NMDAR antibodies in SLE cognitive dysfunction remains elusive. Moreover, the specific contribution of anti-P antibodies has not been reported yet. The present study attempts to clarify the contribution of anti-NMDAR and anti-P antibodies to cognitive dysfunction in SLE.
  
  
  METHODS
  The Cambridge Neuropsychological Test Automated Battery (CANTAB) was used to assess a wide range of cognitive function areas in 133 Chilean women with SLE. ANCOVA models included autoantibodies, patient and disease features.
  
  
  RESULTS
  Cognitive deficit was found in 20%. Higher SLEDAI-2K scores were associated with impairment in spatial memory and learning abilities, whereas both anti-NMDAR and anti-P antibodies contributed to deficits in attention and spatial planning abilities, which reflect fronto-parietal cortex dysfunctions.
  
  
  CONCLUSIONS
  These results reveal an association of active disease together with specific circulating autoantibodies, such as anti-NMDAR and anti-P, with cognitive dysfunction in SLE patients.
authors.affiliation: Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina massardo@med.puc.cl agonzara@med.puc.cl.
authors.forename: L
authors.initials: L
authors.lastname: Massardo
authors.affiliation: Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina Centro de Envejecimiento y Regeneración, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas.
authors.forename: M
authors.initials: M
authors.lastname: Bravo-Zehnder
authors.affiliation: Departamento de Psiquiatría.
authors.forename: J
authors.initials: J
authors.lastname: Calderón
authors.affiliation: Departamento de Psiquiatría.
authors.forename: P
authors.initials: P
authors.lastname: Flores
authors.affiliation: Departamento de Salud Pública, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
authors.forename: O
authors.initials: O
authors.lastname: Padilla
authors.affiliation: Departamento de Psiquiatría.
authors.forename: J M
authors.initials: JM
authors.lastname: Aguirre
authors.affiliation: Institute of Biomedical Sciences, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Scoriels
authors.affiliation: Departamento de Inmunología Clínica y Reumatología, Facultad de Medicina Centro de Envejecimiento y Regeneración, Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas.
authors.forename: A
authors.initials: A
authors.lastname: González
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D003072:Cognition Disorders / Q000097:blood / Q000276:immunology* / Q000523:psychology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology* / Q000523:psychology*; D009483:Neuropsychological Tests; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000276:immunology*; D012269:Ribosomal Proteins / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate; D012269:Ribosomal Proteins
keywords: Neuropsychiatric lupus; anti-NMDAR; anti-ribosomal-P; cognitive dysfunction; systemic lupus erythematosus