title: Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging.
abstract: An oxidation-responsive contrast agent for magnetic resonance imaging was synthesized using Eu(2+) and liposomes. Positive contrast enhancement was observed with Eu(2+), and chemical exchange saturation transfer was observed before and after oxidation of Eu(2+). Orthogonal detection modes render the concentration of Eu inconsequential to molecular information provided through imaging.
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. mallen@chem.wayne.edu.
authors.forename: Levi A
authors.initials: LA
authors.lastname: Ekanger
authors.forename: Meser M
authors.initials: MM
authors.lastname: Ali
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D008081:Liposomes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D008081:Liposomes; D005063:Europium