title: Determinants of anterior chamber angle narrowing after mydriasis in the patients with cataract.
abstract: OBJECTIVE
  To identify the determinants of anterior chamber angle narrowing after mydriasis by quantitative assessment of the anterior chamber components using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  In this intervention study, anterior chamber angle analysis was performed using AS-OCT in patients with cataract before pharmacological pupillary dilation and 30 min afterwards. Angle narrowing was quantified by the change of angle opening distance 500 after mydriasis (ΔAOD500). Multivariate linear regression and stepwise selection regression were used to identify which parameters in AS-OCT significantly determined ΔAOD500.
  
  
  RESULTS
  One hundred and two Japanese patients (age, mean ± standard deviation, 71.9 ± 11.2 years) were enrolled. Multivariate analysis indicated that smaller ΔAOD500 were significantly associated with larger lens vault (LV; P < 0.001), larger iris area (IA; P = 0.003), and posterior corneal arch distance (PCAL; P = 0.01). Stepwise linear regression analysis revealed that smaller ΔAOD500 was independently associated with larger LV (partial R (2) = 0.232, P < 0.001), larger IA (partial R (2) = 0.080, P = 0.001), and smaller PCAL (partial R (2) = 0.066, P = 0.002) before mydriasis. These three factors explained 37.7 % of the decrease in ΔAOD500.
  
  
  CONCLUSIONS
  Larger LV, larger IA, and smaller PCAL contribute considerably to anterior chamber angle narrowing after mydriasis in patients with cataract.
authors.affiliation: Department of Ophthalmology, Faculty of Medical Science, University of Fukui, 23-3, Shimoaizuki, Eiheiji, Yoshida, Fukui, 910-1193, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Arimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takamura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takihara
authors.forename: Takehiro
authors.initials: T
authors.lastname: Matsumura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tomomatsu
authors.forename: Masaru
authors.initials: M
authors.lastname: Inatani
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology*; D002386:Cataract / Q000150:complications*; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis* / Q000209:etiology; D006068:Gonioscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D010656:Phenylephrine / Q000008:administration & dosage; D011680:Pupil / Q000187:drug effects*; D041623:Tomography, Optical Coherence; D014331:Tropicamide / Q000008:administration & dosage
chemical_list: D009184:Mydriatics; D010656:Phenylephrine; D014331:Tropicamide