title: [The dynamics of biochemical blood indicators in patients with hemophilia and posttransfusion hepatitis receiving hepatotropic therapy].
abstract: The sample of 128 patients with hemophilia aged from 1 to 71 years (Me 32) was examined. The study established that 109 patients (85.2%) had hemophilia A and 19 patients (14.8%) had hemophilia B. In 77 adult patients (60%) markers of viruses of hepatitis C and B were detected and the signs of disorders of liver functions were established in 64% out of them. These signs included reliable increasing of levels of AST and ALT, total and conjugated bilirubin, urea and creatinine and absence of any clinical manifestations. The detected alterations served as a background for implementation of hepatotropic therapy with pharmaceutical Heptral. The ademetionin is the reactant of preparation. After two weeks of intravenous application of Heptal the tendency to normalization of content of bilirubin was established. The significant decrease of activity of aminotransferases was detected, nevertheless their levels still overridden physiological standard. This situation required to prescribe pharmaceutical and to continue treatment in out-patient conditions. The continuous repair of functional activity of hepatic cells requires further search of more effective schemes of therapy.
authors.forename: S V
authors.initials: SV
authors.lastname: Ignatiyev
authors.forename: E P
authors.initials: EP
authors.lastname: Ivashkina
authors.forename: S I
authors.initials: SI
authors.lastname: Vorojysova
authors.forename: L N
authors.initials: LN
authors.lastname: Tarasova
authors.forename: T A
authors.initials: TA
authors.lastname: Chernova
authors.forename: M A
authors.initials: MA
authors.lastname: Timofeyeva
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006509:Hepatitis B / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006526:Hepatitis C / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008099:Liver / Q000187:drug effects; D008875:Middle Aged; D012436:S-Adenosylmethionine / Q000494:pharmacology / Q000627:therapeutic use*; D000637:Transaminases / Q000097:blood*
chemical_list: D012436:S-Adenosylmethionine; D000637:Transaminases; D001663:Bilirubin