title: Hyperhomocysteinemia in patients with polypoidal choroidal vasculopathy: a case control study.
abstract: OBJECTIVE
  To determine whether elevated plasma homocysteine and serum high sensitivity C-reactive protein (hsCRP) levels, two established risk factors of vascular diseases, are associated with polypoidal choroidal vasculopathy (PCV).
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  One hundred and nineteen consecutive patients with PCV and 119 matched controls were enrolled in a tertiary hospital from September 2008 to June 2013. Plasma homocysteine and serum hsCRP levels were measured. Associations among plasma homocysteine, serum hsCRP levels and PCV were further evaluated using multivariable logistic regression analysis.
  
  
  RESULTS
  The median plasma homocysteine level was significantly higher in patients with PCV than in the controls (12.20 µmol/L vs. 9.80 µmol/L, p<0.001). The median serum hsCRP level was slightly higher in the PCV group (0.16 mg/dl vs. 0.11 mg/dl in control group, p = 0.07). After multivariable logistic regression analysis, each 1 µmol/L increase of plasma homocysteine was associated with a 1.5-fold increase in likelihood of having PCV (OR, 1.54; 95% confidence interval (CI), 1.33-1.79, p<0.001).
  
  
  CONCLUSIONS
  Hyperhomocysteinemia was associated with PCV and might play a role in the pathogenesis of PCV.
authors.affiliation: Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Hui-Chen
authors.initials: HC
authors.lastname: Cheng
authors.affiliation: Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Ophthalmology, Cheng Hsin Rehabilitation Medical Center, Taipei, Taiwan.
authors.forename: Jorn-Hon
authors.initials: JH
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
authors.forename: Shui-Mei
authors.initials: SM
authors.lastname: Lee
authors.affiliation: Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan; Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; Biomedical Electronics Translational Research Center, National Chiao Tung University, Hsinchu, Taiwan.
authors.forename: Po-Kang
authors.initials: PK
authors.lastname: Lin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D002829:Choroid / Q000098:blood supply / Q000473:pathology; D015862:Choroid Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein