title: Prognostic value of preoperative inflammatory markers in Chinese patients with breast cancer.
abstract: Cancer-associated inflammation is a key determinant of disease progression and survival in most cancers. The aim of our study was to assess the predictive value of preoperative inflammatory markers, such as the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio, red cell distribution width (RDW), and mean platelet volume, for survival in breast cancer patients. In total, 608 breast cancer patients operated on between January 2009 and December 2011 were included in this observational study. The association between preoperative inflammatory markers and survival outcomes was analyzed. Patients with high NLR (>2.57) or high RDW (>13.45%) showed a significantly lower overall survival rate than those with lower NLR (≤2.57) or lower RDW (≤13.45%). NLR and RDW, along with node stage and molecular subtypes, were independent prognostic factors. There was a significant survival difference according to NLR in the luminal A and triple-negative subtypes (93.3% versus 99.3%, P=0.001; 68.8% versus 95.1%, P=0.000, respectively). The triple-negative subtype was the only subtype in which higher RDW patients showed significantly poor prognosis (81.3% versus 95.5%, P=0.025). Pre-operation NLR and RDW is a convenient, easily measured prognostic indicator for patients with breast cancer, especially in patients with the triple-negative subtype.
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Minya
authors.initials: M
authors.lastname: Yao
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Gastrointestinal Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Hailong
authors.initials: H
authors.lastname: Jin
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Kezhen
authors.initials: K
authors.lastname: Lv
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wei
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Chengyong
authors.initials: C
authors.lastname: Du
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Shuqian
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Bajin
authors.initials: B
authors.lastname: Wei
authors.affiliation: Department of Breast Center, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
authors.forename: Peifen
authors.initials: P
authors.lastname: Fu
keywords: NLR; RDW; neutrophil-to-lymphocyte ratio; overall survival; red cell distribution width