title: Feasibility of isotope harvesting at a projectile fragmentation facility: ⁶⁷Cu.
abstract: The work presented here describes a proof-of-principle experiment for the chemical extraction of (67)Cu from an aqueous beam stop at the National Superconducting Cyclotron Laboratory (NSCL). A 76 MeV/A (67)Cu beam was stopped in water, successfully isolated from the aqueous solution through a series of chemical separations involving a chelating disk and anion exchange chromatography, then bound to NOTA-conjugated Herceptin antibodies, and the bound activity was validated using instant thin-layer chromatography (ITLC). The chemical extraction efficiency was found to be 88 ± 3% and the radiochemical yield was ≥95%. These results show that extraction of radioisotopes from an aqueous projectile-fragment beam dump is a feasible method for obtaining radiochemically pure isotopes.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, MO. 63110.
authors.forename: Tara
authors.initials: T
authors.lastname: Mastren
authors.affiliation: Department of Chemistry, Hope College, Holland, MI 49423.
authors.forename: Aranh
authors.initials: A
authors.lastname: Pen
authors.affiliation: Department of Chemistry, Hope College, Holland, MI 49423.
authors.forename: Graham F
authors.initials: GF
authors.lastname: Peaslee
authors.affiliation: Department of Chemistry, Hope College, Holland, MI 49423.
authors.forename: Nick
authors.initials: N
authors.lastname: Wozniak
authors.affiliation: Department of Radiology, Washington University, St. Louis, MO63110.
authors.forename: Shaun
authors.initials: S
authors.lastname: Loveless
authors.affiliation: Department of Chemistry, Hope College, Holland, MI 49423.
authors.forename: Scott
authors.initials: S
authors.lastname: Essenmacher
authors.affiliation: Department of Chemistry, Washington University, St. Louis, MO. 63110.
authors.forename: Lee G
authors.initials: LG
authors.lastname: Sobotka
authors.affiliation: Department of Chemistry, Michigan State University, E. Lansing, MI 48824.
authors.forename: David J
authors.initials: DJ
authors.lastname: Morrissey
authors.affiliation: 1] Department of Chemistry, Washington University, St. Louis, MO. 63110 [2] Department of Radiology, Washington University, St. Louis, MO63110.
authors.forename: Suzanne E
authors.initials: SE
authors.lastname: Lapi