title: [Therapy-induced tumor regression and regression grading in lung cancer].
abstract: After neoadjuvant therapy of non-small cell lung cancer, the extent of therapy-induced tumor regression in corresponding resection specimens of primary tumors and lymph nodes represents an independent prognostic factor. In the former tumor area, different sized target-like foci with central necrosis, adjoining narrow foam cell rim, peripheral vascular granulation tissue and transition into a marked scarry fibrosis can be found after neoadjuvant therapy. Morphological changes indicating therapy-induced tumor regression can be graded according to the Bochum regression grading system. Therapy-induced cytomorphological changes do not allow reliable conclusions on the success of the applied neoadjuvant therapy and should not form the basis of cytopathological grading.
authors.affiliation: Zentrum für Pathologie, Klinikum Bremen-Mitte, St.-Jürgen-Str. 1, 28177, Bremen, Deutschland, klaus.junker@klinikum-bremen-mitte.de.
authors.forename: K
authors.initials: K
authors.lastname: Junker
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D006801:Humans; D008168:Lung / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D008198:Lymph Nodes / Q000473:pathology; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading; D011379:Prognosis; D016896:Treatment Outcome