title: Quality evaluation of pharmaceutical formulations containing hydrochlorothiazide.
abstract: Hydrochlorothiazide is a diuretic used to treat hypertension that belongs to class IV of the Biopharmaceutics Classification System. The drug was evaluated by quality control, thermal characterization tests, and pharmaceutical formulation compatibility studies. It was concluded that the generic drug, Lab 2, was not a pharmaceutical equivalent. The compounded drugs, Lab 5 and Lab 6, produced unsatisfactory but expected results, since there is no requirement for dissolution and dissolution profile testing for the commercialization of these products. In a compatibility study, lactose and mannitol were shown to be incompatible with HCTZ, which may explain the lack of equivalence of the generic pharmaceutical product, associated with other situations.
authors.affiliation: Departamento de Ciências da Saúde, Centro Universitário Norte do Espírito Santo, UFES, Rodovia BR 101 Norte, km 60, 29932-540 São Mateus, ES, Brazil. oliveirama.ufes@gmail.com.
authors.forename: Marcelo Antonio
authors.initials: MA
authors.lastname: de Oliveira
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627-31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Maria Irene
authors.initials: MI
authors.lastname: Yoshida
authors.affiliation: Departamento de Ciências da Saúde, Centro Universitário Norte do Espírito Santo, UFES, Rodovia BR 101 Norte, km 60, 29932-540 São Mateus, ES, Brazil.
authors.forename: Daphne Carina Gonçalves Monteiro da
authors.initials: DC
authors.lastname: Silva
mesh_terms: D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D004232:Diuretics; D004339:Drug Compounding; D006801:Humans; D006852:Hydrochlorothiazide / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011786:Quality Control
chemical_list: D004232:Diuretics; D004364:Pharmaceutical Preparations; D006852:Hydrochlorothiazide