title: Anterior segment optical coherence tomography parameters in phacomorphic angle closure and mature cataracts.
abstract: OBJECTIVE
  To describe anterior segment optical coherence tomography (AS-OCT) parameters in phacomorphic angle closure eyes, mature cataract eyes, and their fellow eyes, and identify those parameters that could be used to differentiate phacomorphic angle closure eyes from those with mature cataract and no phacomorphic angle closure.
  
  
  METHODS
  In this cross-sectional study, a total of 33 phacomorphic angle closure subjects and 34 control patients with unilateral mature cataracts were enrolled. All patients underwent AS-OCT imaging and A-scan biometry of both eyes. Anterior chamber depth (ACD), anterior chamber area (ACA), iris thickness, iris curvature, lens vault (LV), and angle parameters, including angle opening distance (AOD750) and trabecular-iris space area (TISA750), were measured in qualified images using customized software and compared among eyes with phacomorphic angle closure, mature cataract eyes, and their fellow eyes.
  
  
  RESULTS
  There was no significant difference in axial length among the four groups. Phacomorphic angle closure had the smallest angle (AOD750, TISA750) and anterior chamber parameters (ACD, ACA, anterior chamber width) and the greatest LV among the groups. This pattern was similar when comparing fellow eyes of mature cataract patients and fellow eyes of phacomorphic angle closure. Anterior chamber area less than 18.62 mm(2), ACD less than 2.60 mm, LV greater than 532.0 μm, and AOD750 less than 0.218 mm had the highest odds ratios (ORs) for distinguishing fellow eyes of phacomorphic angle closure versus fellow eyes of mature cataracts, with OR values of 9.90, 8.31, 7.91, and 7.91, respectively. Logistic regression showed that ACA less than 18.62 was the major parameter associated with fellow eyes of phacomorphic angle closure (OR = 10.96, P < 0.001).
  
  
  CONCLUSIONS
  Anterior chamber depth, ACA, AOD750, and LV are powerful indicators in differentiating phacomorphic angle closure eyes from those with mature cataract and their fellow eyes.
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Mansouri
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Farshid
authors.initials: F
authors.lastname: Ramezani
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran Koret Vision Center, University of California, San Francisco Medical School, San Francisco, California, United States.
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Tabatabaie
authors.affiliation: Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Abdi
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Mingguang
authors.initials: M
authors.lastname: He
authors.affiliation: Koret Vision Center, University of California, San Francisco Medical School, San Francisco, California, United States.
authors.forename: Shan C
authors.initials: SC
authors.lastname: Lin
mesh_terms: D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D002386:Cataract / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular
keywords: anterior chamber depth; cataract; iris thickness; lens vault; phacomorphic glaucoma