title: Effect of the percentage of body fat on surgical, clinical and pathological outcomes in women with endometrial cancer.
abstract: OBJECTIVE
  This study used the measure of percentage of body fat (%BF) to define obesity and evaluated the effect of percentage of %BF on clinical, surgical and pathological features in women with endometrial cancer.
  
  
  METHODS
  Between 2011 and 2013, bioelectrical impedance analysis and body size measurements of 94 patients whose endometrial biopsy revealed endometrial cancer were obtained. Patients were divided into two groups according to body mass index (BMI) (normal, < 30 kg/m(2); elevated, ≥ 30 kg/m(2)), and also classified by %BF (normal, < 32%; elevated, ≥ 32%).
  
  
  RESULTS
  The patients' mean age was 55.0 ± 10.9 years. Mean %BF and BMI were 40.8% ± 9.8% and 32.9 ± 7.5, respectively. Eighty-three (88%) patients were obese according to %BF; 54 (57%) were obese according to BMI. Patients with elevated %BF were more likely to have less than 50% myometrial invasion (P = 0.004). Significantly more para-aortic lymph nodes were retrieved in patients with normal %BF or BMI (P < 0.001, P < 0.001). Patients with elevated %BF had longer operating times (P = 0.043) and were more likely to have stage I disease than patients with normal %BF (P < 0.001).
  
  
  CONCLUSIONS
  Endometrial cancer patients with an elevated %BF are more likely to have stage I disease and less than 50% myometrial invasion than patients with normal %BF. Defining obesity by BF may provide better estimation of obesity prevalence in patients with endometrial cancer and further understanding the relationship between BF with endometrial cancer may give more information about the effects of obesity on endometrial cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Selçuk University Medicine Faculty, Konya, Turkey.
authors.forename: Ozlem Secilmis
authors.initials: OS
authors.lastname: Kerimoglu
authors.forename: Aybike
authors.initials: A
authors.lastname: Pekin
authors.forename: Setenay Arzu
authors.initials: SA
authors.lastname: Yilmaz
authors.forename: Guler
authors.initials: G
authors.lastname: Yavas
authors.forename: Fatma
authors.initials: F
authors.lastname: Beyhekim
authors.forename: Ayşe Ayda
authors.initials: AA
authors.lastname: Demirtaş
authors.forename: Nasuh Utku
authors.initials: NU
authors.lastname: Dogan
authors.forename: Tolgay Tuyan
authors.initials: TT
authors.lastname: İlhan
authors.forename: Cetin
authors.initials: C
authors.lastname: Celik
mesh_terms: D050154:Adiposity; D000328:Adult; D000368:Aged; D001011:Aorta; D015992:Body Mass Index; D018269:Carcinoma, Endometrioid / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D017097:Electric Impedance; D016889:Endometrial Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009765:Obesity / Q000150:complications / Q000175:diagnosis; D061646:Operative Time
keywords: bioelectrical impedance analysis; body mass index; endometrial cancer; obesity; percentage of body fat