title: Copper-catalyzed direct amidation of heterocycles with N-fluorobenzenesulfonimide.
abstract: A highly efficient amidation reaction of heterocycles with N-fluorobenzenesulfonimide (NFSI) has been developed, presumably proceeding via C-H bond activation. Cuprous iodide was employed as the catalyst, and various α-amidated heterocycle derivatives have been generated in good to excellent yields. This chemistry endowed an economic method of synthesis of valuable amidated heterocycles through a direct C-N bond-coupling processes.
authors.affiliation: Department of Chemistry, Zhejiang University , Hangzhou 310027, People's Republic of China.
authors.forename: Sichang
authors.initials: S
authors.lastname: Wang
authors.forename: Zhangqin
authors.initials: Z
authors.lastname: Ni
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Jichao
authors.initials: J
authors.lastname: Wang
authors.forename: Yuanjiang
authors.initials: Y
authors.lastname: Pan
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006860:Hydrogen Bonding; D015394:Molecular Structure; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D003300:Copper; D006571:Heterocyclic Compounds; D013449:Sulfonamides; C523711:N-fluorobenzenesulfonimide; D000096926:Benzenesulfonamides