title: 8q24 rs4242382 polymorphism is a risk factor for prostate cancer among multi-ethnic populations: evidence from clinical detection in China and a meta-analysis.
abstract: BACKGROUND
  Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations.
  
  
  METHODS
  Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically- confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype.
  
  
  RESULTS
  The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, P=7.3?10-5), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, Padj=1.1?10-4). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ≥65 years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype (P=4.6?10-5-3.0?10-2). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, P=1.0?10-5) across Asian, Caucasian and African American populations.
  
  
  CONCLUSIONS
  The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.
authors.affiliation: The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics, Chinese Ministry of Health, Beijing, China E-mail : wangjy@bjhmoh.com, yang_ze@sina.com.
authors.forename: Cheng-Xiao
authors.initials: CX
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Xu
authors.forename: Kuo
authors.initials: K
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Wei
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Shi
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Yao-Guang
authors.initials: YG
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Si-Ying
authors.initials: SY
authors.lastname: Liang
authors.forename: Fan
authors.initials: F
authors.lastname: Zhao
authors.forename: Yu-Rong
authors.initials: YR
authors.lastname: Zhang
authors.forename: Na-Na
authors.initials: NN
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Sun
authors.forename: Xiao-Quan
authors.initials: XQ
authors.lastname: Zhu
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Yuan
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Yi-Ge
authors.initials: YG
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: Tang
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Jiao
authors.forename: Zheng-Hao
authors.initials: ZH
authors.lastname: Huo
authors.forename: Jian-Ye
authors.initials: JY
authors.lastname: Wang
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics*; D012307:Risk Factors