title: Significance of MTA1 in the molecular characterization of osteosarcoma.
abstract: Osteosarcoma is the most common malignant bone tumor in children and characterized by aggressive biologic behavior of metastatic propensity to the lung. Change of treatment paradigm brings survival benefit; however, 5-year survival rate is still low in patients having metastastatic foci at diagnosis for a few decades. Metastasis-associated protein (MTA) family is a group of ubiquitously expressed coregulators, which influences on tumor invasiveness or metastasis. MTA1 has been investigated in various cancers including osteosarcoma, and its overexpression is associated with high-risk features of cancers. In this review, we described various molecular studies of osteosarcoma, especially associated with MTA1.
authors.affiliation: Department of Pathology, Chonnam National University Medical School, 160, Baekseo-ro, Dong-gu, Gwangju, 501-757, Korea, succeedsoon@hanmail.net.
authors.forename: Sung Sun
authors.initials: SS
authors.lastname: Kim
authors.forename: Yong-Koo
authors.initials: YK
authors.lastname: Park
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D006655:Histone Deacetylases / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009361:Neoplasm Invasiveness / Q000235:genetics; D012516:Osteosarcoma / Q000235:genetics* / Q000473:pathology; D012097:Repressor Proteins / Q000235:genetics*; D015534:Trans-Activators
chemical_list: D035683:MicroRNAs; C089320:MTA1 protein, human; D012097:Repressor Proteins; D015534:Trans-Activators; D006655:Histone Deacetylases