title: [Effect of decitabine on immune regulation in patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation].
abstract: Based on the representative articles in recent years, the different mechanisms of decitabine on immune regulation in patients with acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (HSCT) are summarized. Decitabine improves the expression of WT1 gene to stimulate specific cytotoxic T cells which can enhance graft versus leukemia effect (GVL) and improve the expression of FOXP3 gene to stimulate regulatory T cells so as to inhibit the acute graft versus host disease (GVHD). Through the above-mentimed mechanisms, decitabine can improve both therapeutic effect and quality of life in the patients with AML after allogeneic HSCT.
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Suzhou 215000, Jiangsu Province, China.
authors.forename: Hui-Fei
authors.initials: HF
authors.lastname: Zheng
authors.affiliation: Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Provincial Institute of Hematology, Suzhou 215000, Jiangsu Province, China. E-mail: zhenzhenfu@hotmail.com.
authors.forename: Zheng-Zheng
authors.initials: ZZ
authors.lastname: Fu
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077209:Decitabine; D020544:Graft vs Leukemia Effect; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000628:therapy; D011788:Quality of Life; D013602:T-Lymphocytes, Cytotoxic; D050378:T-Lymphocytes, Regulatory; D014184:Transplantation, Homologous
chemical_list: D000964:Antimetabolites, Antineoplastic; D000077209:Decitabine; D001374:Azacitidine