title: An automated system for determining drug solubility based on laser monitoring technique.
abstract: The aqueous solubility of a drug candidate is a vital physicochemical property that stops a drug candidate from proceeding further in the drug development processes. Classical solubility determination methods, which are commonly used in pharmaceutical laboratories, are expensive and time-consuming. In this work, an automated determination method is proposed that is based on a laser monitoring technique, and the validity of the measured solubilities is checked by comparing the measured solubilities of acetaminophen at various temperatures as proposed in various literatures. An additional set of acetaminophen solubilities in various concentrations of a surface active agent is measured at various temperatures, which has been reported for the first time, and it could be applied in the pharmaceutical industry, where solubilization of acetaminophen in aqueous solutions is required.
authors.affiliation: Department of Mechatronic Engineering, International Campus, University of Tabriz, Tabriz, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Jouyban-Gharamaleki
authors.affiliation: Tabriz Technical Training Center No. 2, Tabriz, Iran.
authors.forename: Karim
authors.initials: K
authors.lastname: Jouyban-Gharamaleki
authors.affiliation: Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical of Sciences, Tabriz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shayanfar
authors.affiliation: Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mehry
authors.initials: M
authors.lastname: Khoubnasabjafari
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Pharmaceutical Engineering Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran ajouyban@hotmail.com.
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Jouyban
mesh_terms: D057205:Automation, Laboratory / Q000379:methods*; D055808:Drug Discovery / Q000379:methods*; D007834:Lasers; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations
keywords: aqueous solubility determination; drug laser monitoring