title: α-Trifluoromethyl-(indol-3-yl)methanols as trifluoromethylated C3 1,3-dipoles: [3+2] cycloaddition for the synthesis of 1-(trifluoromethyl)-cyclopenta[b]indole alkaloids.
abstract: The first formal [3+2] cycloaddition using α-trifluoromethyl-(indol-3-yl)methanols as the trifluoromethylated C3 1,3-dipoles for the construction of the five-membered carbocycle of 1-trifluoromethylated cyclopenta[b]indole alkaloids is described. An unprecedented step-wise dehydrative alkenylation of α-trifluoromethyl alcohols was revealed as the crucial transformation.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China. panl948@nenu.edu.cn liuqun@nenu.edu.cn.
authors.forename: Jinhuan
authors.initials: J
authors.lastname: Dong
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D061565:Cycloaddition Reaction; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry*; D008745:Methylation
chemical_list: D026121:Indole Alkaloids; D000432:Methanol