title: Zebrafish fgf10b has a complementary function to fgf10a in liver and pancreas development.
abstract: Fgf10 is a critical growth factor in mammals for development of endodermal organs such as the liver, pancreas, lung, and gut. Due to whole genome duplication, the zebrafish has two fgf10 orthologs, fgf10a and fgf10b. While fgf10a has a role in development of the esophagus and swimbladder, we found in the present study that fgf10b had a complementary expression pattern in the liver, pancreas, and gut. Morpholino knockdown of Fgf10b further confirmed its essential role in the normal development of liver and pancreas. Thus, our data provide another example of functional partition of two duplicated othologous genes during evolution.
authors.affiliation: Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
authors.forename: Chuan
authors.initials: C
authors.lastname: Yan
authors.forename: Weiling
authors.initials: W
authors.lastname: Zheng
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Gong
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D051526:Fibroblast Growth Factor 10 / Q000235:genetics / Q000378:metabolism*; D020440:Gene Duplication / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D055785:Gene Knockdown Techniques; D006652:Histological Techniques; D007091:Image Processing, Computer-Assisted; D017403:In Situ Hybridization; D007814:Larva / Q000033:anatomy & histology; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D060172:Morpholinos; D010179:Pancreas / Q000196:embryology / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051526:Fibroblast Growth Factor 10; D060172:Morpholinos; D020033:Protein Isoforms; D029961:Zebrafish Proteins; C520413:fgf10a protein, zebrafish