title: [Early diagnosis of capecitabine-induced acute leukoencephalopathy by using diffusion-weighted MRI].
abstract: A 63-year-old woman with colon cancer who was treated with capecitabine as adjuvant chemotherapy presented with vertigo on day 5, and dysarthria and dysphagia on day 7 of the treatment. Diffusion-weighted magnetic resonance imaging of the brain revealed high signal intensity in the corpus callosum and corona radiata. The patient was diagnosed with acute leukoencephalopathy, and the capecitabine treatment was discontinued. Her symptoms recovered immediately. On the basis of these findings, it can be concluded that diffusion-weighted imaging is useful for the early detection and diagnosis of acute leukoencephalopathy.
authors.affiliation: Dept. of Surgery, Shonankamakura General Hospital.
authors.forename: Rai
authors.initials: R
authors.lastname: Shimoyama
authors.forename: Takushiro
authors.initials: T
authors.lastname: Ban
authors.forename: Katsunori
authors.initials: K
authors.lastname: Miyake
authors.forename: Naoko
authors.initials: N
authors.lastname: Isogai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ikegaya
authors.forename: Jun
authors.initials: J
authors.lastname: Kawachi
authors.forename: Hidemitsu
authors.initials: H
authors.lastname: Ogino
authors.forename: Kazunao
authors.initials: K
authors.lastname: Watanabe
mesh_terms: D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D000069287:Capecitabine; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D038524:Diffusion Magnetic Resonance Imaging; D042241:Early Diagnosis; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D056784:Leukoencephalopathies / Q000139:chemically induced* / Q000473:pathology; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil