title: Selective inhibitors of nuclear export (SINE)--a novel class of anti-cancer agents.
abstract: Dysregulation of the nucleo-cytoplasmic transport of proteins plays an important role in carcinogenesis. The nuclear export of proteins depends on the activity of transport proteins, exportins. Exportins belong to the karyopherin β superfamily. Exportin-1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), mediates transport of around 220 proteins. In this review, we summarized the development of a new class of antitumor drugs, collectively known as selective inhibitors of nuclear export (SINE). KPT-330 (selinexor) as an oral agent is showing activities in early clinical trials in both solid tumors and hematological malignancies.
authors.forename: Kaushal
authors.initials: K
authors.lastname: Parikh
authors.forename: Shundong
authors.initials: S
authors.lastname: Cang
authors.forename: Arunabh
authors.initials: A
authors.lastname: Sekhri
authors.affiliation: Henan Tumor Hospital, Zhengzhou University, Zhengzhou, China. Delong_liu@nymc.edu.
authors.forename: Delong
authors.initials: D
authors.lastname: Liu
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D028884:Karyopherins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D028884:Karyopherins