title: Effect of a topical formulation containing Calophyllum brasiliense Camb. extract on cutaneous wound healing in rats.
abstract: This study evaluated the wound healing effects of topical application of an emulsion containing the HPLC-standardised extract from Calophyllum brasiliense Cambess (Clusiaceae) leaves in rats. The macroscopic analysis demonstrated that the wounds treated with the C. brasiliense emulsion healed earlier than the wounds treated with emulsion base and Dersani®. The percentage of wound healing in the group treated with the C. brasiliense emulsion was significantly higher than in the other groups at 7 and 14 days. On day 14, the animals treated with the C. brasiliense emulsion exhibited a 90.67% reduction of the wound areas. The histological evaluation revealed that on day 21, the group treated with the C. brasiliense emulsion exhibited a significant increase in fibroblasts compared with the other groups. Thus, the C. brasiliense emulsion had healing properties in the topical treatment of wounds and accelerated the healing process.
authors.affiliation: a Programa de Pós-graduação em Promoção da Saúde, Centro Universitário de Maringá, CESUMAR , Av. Guerdner 1610, Jd. Aclimação, 87050-900 Maringá , PR , Brazil.
authors.forename: T V A
authors.initials: TV
authors.lastname: Lordani
authors.forename: M A
authors.initials: MA
authors.lastname: Brenzan
authors.forename: L E R
authors.initials: LE
authors.lastname: Cortez
authors.forename: C R F
authors.initials: CR
authors.lastname: Lordani
authors.forename: P A
authors.initials: PA
authors.lastname: Honda
authors.forename: M V C
authors.initials: MV
authors.lastname: Lonardoni
authors.forename: D A G
authors.initials: DA
authors.lastname: Cortez
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D029759:Calophyllum / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004655:Emulsions; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004655:Emulsions; D010936:Plant Extracts
keywords: Calophyllum brasiliense; crude extract; rat; topical treatment; wound healing