title: Extranodal NK/T Cell Lymphoma of the Jejunum Complicated by Hemophagocytic Syndrome: Practical Problems Encountered by a Pathologist.
abstract: Extranodal NK/Tcell lymphomas (ENKTL) are rare, aggressive lymphomas. The most common primary site of involvement is the nasal cavity, nasopharynx and paranasal sinuses. The other sites of primary involvement are skin, gastrointestinal tract and testis. Advanced disease can show lymph node, bone marrow and peripheral blood involvement. We report a case of ENKTL of the jejunum, showing peripheral pancytopenia and haemophagocytosis in the bone marrow. The intestine showed multiple intestinal perforations, with evidence of infiltration by lymphoma with coexistent strongyloides infestation. The patient showed disseminated disease in the form of lymphadenopathy and had a rapidly downhill course and expired on 5th day of admission. We also discuss the problems encountered by the pathologist in diagnosing these uncommon lymphomas.
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Jinkala Sree
authors.initials: JS
authors.lastname: Rekha
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Rakhee
authors.initials: R
authors.lastname: Kar
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Sajini Elizabeth
authors.initials: SE
authors.lastname: Jacob
authors.affiliation: Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Neelaiah
authors.initials: N
authors.lastname: Siddaraju
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Bettadpura Shamana
authors.initials: BS
authors.lastname: Suryanarayana
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Molly Mary
authors.initials: MM
authors.lastname: Thabah
authors.affiliation: Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Naik
authors.affiliation: Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006 India.
authors.forename: Nanda Kishore
authors.initials: NK
authors.lastname: Maroju
keywords: Extranodal NK/Tcell lymphomas (ENKTL); Haemophagocytosis