title: Active Achilles tendon kinesitherapy accelerates Achilles tendon repair by promoting neurite regeneration.
abstract: Active Achilles tendon kinesitherapy facilitates the functional recovery of a ruptured Achilles tendon. However, protein expression during the healing process remains a controversial issue. New Zealand rabbits, aged 14 weeks, underwent tenotomy followed immediately by Achilles tendon microsurgery to repair the Achilles tendon rupture. The tendon was then immobilized or subjected to postoperative early motion treatment (kinesitherapy). Mass spectrography results showed that after 14 days of motion treatment, 18 protein spots were differentially expressed, among which, 12 were up-regulated, consisting of gelsolin isoform b and neurite growth-related protein collapsing response mediator protein 2. Western blot analysis showed that gelsolin isoform b was up-regulated at days 7-21 of motion treatment. These findings suggest that active Achilles tendon kinesitherapy promotes the neurite regeneration of a ruptured Achilles tendon and gelsolin isoform b can be used as a biomarker for Achilles tendon healing after kinesitherapy.
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Jiasharete
authors.initials: J
authors.lastname: Jielile
authors.affiliation: Urumqi Center for Disease Control and Prevention, Urumqi 830026, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Minawa
authors.initials: M
authors.lastname: Aibai
authors.affiliation: Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Gulnur
authors.initials: G
authors.lastname: Sabirhazi
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Nuerai
authors.initials: N
authors.lastname: Shawutali
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Wulanbai
authors.initials: W
authors.lastname: Tangkejie
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Aynaz
authors.initials: A
authors.lastname: Badelhan
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Yeermike
authors.initials: Y
authors.lastname: Nuerduola
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Turde
authors.initials: T
authors.lastname: Satewalede
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Darehan
authors.initials: D
authors.lastname: Buranbai
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Beicen
authors.initials: B
authors.lastname: Hunapia
authors.affiliation: Department of Microsurgical Repair and Reconstruction, First Teaching Hospital of Xinjiang Medical University & Sports Medicine Research Center, Research Institute of Orthopedics of Xinjiang Uyghur Autonomous Region, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Ayidaer
authors.initials: A
authors.lastname: Jialihasi
authors.affiliation: Department of Orthopedics, Third Teaching Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Bai
authors.affiliation: The Research Institute of Kazakh Traditional Medicine of Ili Kazakh Autonomous Prefecture of Xinjiang, Yining 835000, Ili Kazakh Autonomous Prefecture of Xinjiang, China.
authors.forename: Murat
authors.initials: M
authors.lastname: Kizaibek
keywords: Achilles tendon; achilles tendon rupture; early; exercise; functional exercise; healing; marker; motion; proteomics; tissue repair