title: Successful antiretroviral therapy by using unusual antiretroviral combinations in heavily pre-treated patients: two case reports.
abstract: In the context of HIV-infected patients with several past antiretroviral therapies and multiple failures, it is possible to be faced with viruses resistant to all drug classes. We report on two HIV-1 infected patients in which the historical genotype showed mutations against all the major drug classes and in which viral suppression has been obtained by non-conventional antiretroviral therapy regimens, including the combination of darunavir at high dosage (800 mg bid), dolutegravir (50 mg bid) and a third agent, i.e. enfuvirtide in the first case and etravirine in the second one.
authors.affiliation: Infectious Diseases Unit, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Taramasso
authors.affiliation: Infectious Diseases Department, Sanremo Hospital, Sanremo, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Dentone
authors.affiliation: Infectious Diseases Unit, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Alessandrini
authors.affiliation: Department of Health Sciences (DISSAL)-Section of Virology, University of Genoa, Genoa, Italy.
authors.forename: Bianca
authors.initials: B
authors.lastname: Bruzzone
authors.affiliation: Department of Health Sciences (DISSAL)-Section of Virology, University of Genoa, Genoa, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Icardi
authors.affiliation: Pharmacology Department, Pasteur University Hospital, Centre Hopitalier Universitaire (CHU), Nice, France.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Garraffo
authors.affiliation: Infectious Diseases Department, Sanremo Hospital, Sanremo, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: De Macina
authors.affiliation: Infectious Diseases Unit, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
authors.affiliation: Infectious Diseases Unit, IRCCS AOU San Martino-IST, University of Genoa, Genoa, Italy antonio.dibiagio@hsanmartino.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
mesh_terms: D000328:Adult; D000368:Aged; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D024882:Drug Resistance, Viral / Q000187:drug effects; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D019562:Viral Load
keywords: AIDS; HIV; antiretroviral therapy; darunavir; dolutegravir; resistance; treatment; treatment experienced