title: Signalling dynamics in vertebrate segmentation.
abstract: Segmentation of the paraxial mesoderm is a major event of vertebrate development that establishes the metameric patterning of the body axis. This process involves the periodic formation of sequential units, termed somites, from the presomitic mesoderm. Somite formation relies on a molecular oscillator, the segmentation clock, which controls the rhythmic activation of several signalling pathways and leads to the oscillatory expression of a subset of genes in the presomitic mesoderm. The response to the periodic signal of the clock, leading to the establishment of the segmental pre-pattern, is gated by a system of travelling signalling gradients, often referred to as the wavefront. Recent studies have advanced our understanding of the molecular mechanisms involved in the generation of oscillations and how they interact and are coordinated to activate the segmental gene expression programme.
authors.affiliation: 1] Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch, 67400, France. [2] Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
authors.forename: Alexis
authors.initials: A
authors.lastname: Hubaud
authors.affiliation: 1] Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), CNRS (UMR 7104), Inserm U964, Université de Strasbourg, Illkirch, 67400, France. [2] Department of Genetics, Harvard Medical School and Department of Pathology, Brigham and Woman's Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
authors.forename: Olivier
authors.initials: O
authors.lastname: Pourquié
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000235:genetics; D019521:Body Patterning; D056926:CLOCK Proteins / Q000235:genetics / Q000378:metabolism; D047108:Embryonic Development / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D008954:Models, Biological; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014714:Vertebrates / Q000196:embryology / Q000235:genetics / Q000378:metabolism*; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D051153:Wnt Proteins; D056926:CLOCK Proteins