title: The threat of human influenza: the viruses, disease impacts, and vaccine solutions.
abstract: Influenza is an acute respiratory illness that remains an important cause of excessive morbidity and mortality with substantial economic cost to the population. Influenza, being a virus that frequently mutates, is not amenable to elimination. Vaccination remains the most effective preventive measure. This review summarises the latest developments in the fields of biology and epidemiology relating to clinical and economic impacts of influenza disease, and vaccination. We suggest that future efforts should focus on developing safer, more effective, and cost-effective prophylactic vaccines for influenza.
authors.forename: Jiehui Kevin
authors.initials: JK
authors.lastname: Yin
authors.forename: Glenn
authors.initials: G
authors.lastname: Salkeld
authors.forename: Leon
authors.initials: L
authors.lastname: Heron
authors.forename: Gulam
authors.initials: G
authors.lastname: Khandaker
authors.forename: Harunor
authors.initials: H
authors.lastname: Rashid
authors.affiliation: National Centre for Immunisation Research and Surveillance (NCIRS), The Children's Hospital at Westmead, Locked Bag 4001, Westmead NSW 2145, Australia. kevin.yin@health.nsw.gov.au.
authors.forename: Robert
authors.initials: R
authors.lastname: Booy
mesh_terms: D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology; D009975:Orthomyxoviridae / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity*; D014611:Vaccination / Q000191:economics
chemical_list: D007252:Influenza Vaccines