title: Effect of aortic root infusion of sufentanil on ischemia-reperfusion injury in patients undergoing mitral valve replacement.
abstract: OBJECTIVE
  This study investigated the effects of aortic root infusion of sufentanil on myocardial ischemia/reperfusion injury in patients undergoing elective mitral valve replacement (MVR) with cardiopulmonary bypass (CPB).
  
  
  METHODS
  A prospective, randomized, clinical study.
  
  
  METHODS
  A university-affiliated teaching hospital.
  
  
  METHODS
  Fifty-three adult patients undergoing elective MVR with CPB.
  
  
  METHODS
  Bolus infusions of sufentanil (0.2 μg/kg, n = 24) or normal saline (n = 29) were administered through the aortic root cardioplegia perfusion catheter 5 minutes before aortic unclamping.
  
  
  RESULTS
  Plasma concentrations of CK-MB and cTnI and variables including heart rate, mean arterial pressure, central venous pressure, cardiac output, stroke volume, duration of mechanical ventilation, length of ICU stay, length of hospital stay, and 24-hour postoperative inotropic scores were recorded. Plasma concentrations of CK-MB and cTnI were significantly lower 4 and 8 hours after aortic unclamping in the sufentanil postconditioning group compared to control (p<0.05). Inotropic drug use, duration of mechanical ventilation, and length of ICU and hospital stays were reduced significantly in the sufentanil postconditioning group compared to control (p< 0.05).
  
  
  CONCLUSIONS
  The present study demonstrated that sufentanil can attenuate myocardial ischemia-reperfusion injury in patients undergoing elective MVR with CPB.
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Youmei
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Xinqi
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China. Electronic address: ay_guew_mz@163.com.
authors.forename: Erwei
authors.initials: E
authors.lastname: Gu
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Xunqin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D001021:Aortic Valve; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002315:Cardiopulmonary Bypass / Q000379:methods; D002408:Catheters, Indwelling; D052279:Creatine Kinase, MB Form / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D011446:Prospective Studies; D012965:Sodium Chloride / Q000008:administration & dosage; D017409:Sufentanil / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D019210:Troponin I / Q000097:blood
chemical_list: D000701:Analgesics, Opioid; D019210:Troponin I; D012965:Sodium Chloride; D017409:Sufentanil; D052279:Creatine Kinase, MB Form
keywords: cardiac surgery; cardiopulmonary bypass; ischemia; postconditioning; reperfusion; sufentanil