title: [Macular thickness in unilateral amblyopia as measured by optical coherence tomography: a meta analysis].
abstract: OBJECTIVE
  To offer a clue for the etiology of amblyopia by systematically comparing the macular thickness measured by optical coherence tomography (OCT) between the amblyopic eye and the fellow normal eye in patients with unilateral amblyopia.
  
  
  METHODS
  Databases including Wanfang, PubMed and others were searched, and data were extracted after quality assessment, then the Meta analysis was performed by the RevMan 5.02 software.
  
  
  RESULTS
  Four studies using the time-domain OCT (TD-OCT) were enrolled in the analysis and all those were anisometropic amblyopic patients. The only one study showed that the foveal minimum thickness is thicker in the amblyopic eyes than the fellow ones (P = 0.045). The meta analysis indicated the amblyopic eyes were 6.82 µm (P < 0.05, 95% CI: 2.81-10.83) thicker in the fovea (1 mm diameter region ). Five trials using the spectral-domain OCT (SD-OCT) were included in the analysis. It showed no significant difference in the foveal minimum thickness between amblyopic and fellow eyes. Also, no significant difference were detected in either anisometropic or strabismic subgroup (P = 0.50). Amblyopic eyes were 7.38 µm thicker in the fovea (1 mm diameter region) (P < 0.05, 95% CI: 3.13 -11.63) and significant difference in the anisometropic subgroup while no significant difference in the strabismic subgroup were detected.
  
  
  CONCLUSIONS
  The macular fovea is thicker in the amblyopic eyes than the fellow ones by the use of OCT, so it is effective to measure the macular thickness of amblyopia in searching evidence for the etiology of amblyopia.
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China; Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing Shijitan Hospital Affiliated to Capital University of Medical Science, Beijing 100191, China.
authors.forename: Si
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China.
authors.forename: Kuo
authors.initials: K
authors.lastname: Liu
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Dong
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China; Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing Shijitan Hospital Affiliated to Capital University of Medical Science, Beijing 100191, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China.
authors.forename: Enzhong
authors.initials: E
authors.lastname: Jin
authors.affiliation: Department of Ophthalmology, the Ninth Clinical Medical College of Peking University, Beijing 100038, China.
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Ren
mesh_terms: D000550:Amblyopia / Q000209:etiology / Q000473:pathology*; D015858:Anisometropia / Q000473:pathology; D005584:Fovea Centralis / Q000473:pathology; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D013285:Strabismus / Q000473:pathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity