title: Mild Cu(I)-catalyzed cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes: efficient synthesis of triazolophenanthridines.
abstract: Linear iodoniums are widely used as arylating reagents. However, cyclic diaryl idodoniums are ignored despite their potential to initiate dual arylations, atom and step economically. In our current work, a three-component cascade reaction of cyclic diaryliodoniums, sodium azide, and alkynes has been successfully achieved under mild conditions, catalyzed by cheap copper species. The regioselectivity associated with unsymmetrical iodoniums was enhanced by installing two methyls ortho and para to the I(III) center. The reaction enables a rapid access to a variety of complex molecules, triazolophenanthridine derivatives.
authors.affiliation: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng East Road, Guangzhou 510060, China.
authors.forename: Zhenquan
authors.initials: Z
authors.lastname: Liu
authors.forename: Daqian
authors.initials: D
authors.lastname: Zhu
authors.forename: Bingling
authors.initials: B
authors.lastname: Luo
authors.forename: Naiyuan
authors.initials: N
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.forename: Yumin
authors.initials: Y
authors.lastname: Hu
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Pi
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Shijun
authors.initials: S
authors.lastname: Wen
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D009861:Onium Compounds / Q000737:chemistry*; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry; D019810:Sodium Azide / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001713:Biphenyl Compounds; D009861:Onium Compounds; D010617:Phenanthridines; C031291:diphenyliodonium; D003300:Copper; D019810:Sodium Azide