title: Inhibition effect of a custom peptide on lung tumors.
abstract: Cecropin B is a natural antimicrobial peptide and CB1a is a custom, engineered modification of it. In vitro, CB1a can kill lung cancer cells at concentrations that do not kill normal lung cells. Furthermore, in vitro, CB1a can disrupt cancer cells from adhering together to form tumor-like spheroids. Mice were xenografted with human lung cancer cells; CB1a could significantly inhibit the growth of tumors in this in vivo model. Docetaxel is a drug in present clinical use against lung cancers; it can have serious side effects because its toxicity is not sufficiently limited to cancer cells. In our studies in mice: CB1a is more toxic to cancer cells than docetaxel, but dramatically less toxic to healthy cells.
authors.affiliation: Nano Biomedical Group, National Nano Device Laboratories, National Applied Research Laboratories, Hsinchu, Taiwan.
authors.forename: Chih-Yu
authors.initials: CY
authors.lastname: Huang
authors.affiliation: Nano Biomedical Group, National Nano Device Laboratories, National Applied Research Laboratories, Hsinchu, Taiwan.
authors.forename: Hsuan-Yu
authors.initials: HY
authors.lastname: Huang
authors.affiliation: Department of Computer Science, University of Warwick, Coventry, United Kingdom.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Forrest
authors.affiliation: Nano Biomedical Group, National Nano Device Laboratories, National Applied Research Laboratories, Hsinchu, Taiwan.
authors.forename: Yun-Ru
authors.initials: YR
authors.lastname: Pan
authors.affiliation: Nano Biomedical Group, National Nano Device Laboratories, National Applied Research Laboratories, Hsinchu, Taiwan.
authors.forename: Wei-Jen
authors.initials: WJ
authors.lastname: Wu
authors.affiliation: Nano Biomedical Group, National Nano Device Laboratories, National Applied Research Laboratories, Hsinchu, Taiwan.
authors.forename: Hueih-Min
authors.initials: HM
authors.lastname: Chen
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D000077143:Docetaxel; D006801:Humans; D019476:Insect Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D043823:Taxoids / Q000494:pharmacology / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
chemical_list: D023181:Antimicrobial Cationic Peptides; D000970:Antineoplastic Agents; C000598900:CB1a protein; D019476:Insect Proteins; D043823:Taxoids; D000077143:Docetaxel; C031162:cecropin B protein, Insecta