title: Real time shear wave elastography in chronic liver diseases: accuracy for predicting liver fibrosis, in comparison with serum markers.
abstract: OBJECTIVE
  To evaluate the correlation between liver stiffness measurement (LSM) by real-time shear wave elastography (SWE) and liver fibrosis stage and the accuracy of LSM for predicting significant and advanced fibrosis, in comparison with serum markers.
  
  
  METHODS
  We consecutively analyzed 70 patients with various chronic liver diseases. Liver fibrosis was staged from F0 to F4 according to the Batts and Ludwig scoring system. Significant and advanced fibrosis was defined as stage F ≥ 2 and F ≥ 3, respectively. The accuracy of prediction for fibrosis was analyzed using receiver operating characteristic curves.
  
  
  RESULTS
  Seventy patients, 15 were belonged to F0-F1 stage, 20 F2, 13 F3 and 22 F4. LSM was increased with progression of fibrosis stage (F0-F1: 6.77 ± 1.72, F2: 9.98 ± 3.99, F3: 15.80 ± 7.73, and F4: 22.09 ± 10.09, P < 0.001). Diagnostic accuracies of LSM for prediction of F ≥ 2 and F ≥ 3 were 0.915 (95%CI: 0.824-0.968, P < 0.001) and 0.913 (95%CI: 0.821-0.967, P < 0.001), respectively. The cut-off values of LSM for prediction of F ≥ 2 and F ≥ 3 were 8.6 kPa with 78.2% sensitivity and 93.3% specificity and 10.46 kPa with 88.6% sensitivity and 80.0% specificity, respectively. However, there were no significant differences between LSM and serum hyaluronic acid and type IV collagen in diagnostic accuracy.
  
  
  CONCLUSIONS
  SWE showed a significant correlation with the severity of liver fibrosis and was useful and accurate to predict significant and advanced fibrosis, comparable with serum markers.
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Jeong
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Tae Yeob
authors.initials: TY
authors.lastname: Kim
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Joo Hyun
authors.initials: JH
authors.lastname: Sohn
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Yongsoo
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Woo Kyoung
authors.initials: WK
authors.lastname: Jeong
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Young-Ha
authors.initials: YH
authors.lastname: Oh
authors.affiliation: Jae Yoon Jeong, Tae Yeob Kim, Joo Hyun Sohn, Kyo-Sang Yoo, Department of Gastroenterology, Hanyang University College of Medicine, Seoul 133-791, South Korea.
authors.forename: Kyo-Sang
authors.initials: KS
authors.lastname: Yoo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D056910:Republic of Korea; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers
keywords: Elastography; Liver biopsy; Liver fibrosis; Liver stiffness; Serum markers