title: In vitro liberation of indomethacin from chitosan gels containing microemulsion in different dissolution mediums.
abstract: The objective of this research is to outline the liberation of indomethacin from different chitosan gels containing O/W microemulsion. The influence of surfactant, sodium lauryl sulfate, in two concentrations (0.5% and 0.75%, w/w) was determined in dissolution medium on the release of indomethacin, which was used as poor water-soluble model drug. Chitosan gels were prepared in four different concentrations of chitosan-1%, 1.5%, 2%, and 3% (w/w). Microemulsion enhanced the liberation of the indomethacin from chitosan gels into all dissolution mediums. Adding the surfactant into phosphate-buffered saline decreased the amount of liberated indomethacin from microemulsion, gel mixture, but increased the drug liberation from pure chitosan gels. It was detected that with the increased concentration of chitosan in the samples, the amount of indomethacin liberated (p < 0.05) also increased. A conclusion was drawn that the liberation of indomethacin from chitosan gels was influenced by increased pH of the samples. The high viscosity induced a higher release of indomethacin from 3% (w/w) chitosan hydrogel at pH 5.8 as compared with 3% (w/w) chitosan hydrogel at pH 3.8. The highest percentage of released indomethacin was determined when a mixture of microemulsion gel with higher chitosan content was used.
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia. Electronic address: lenkalesa@gmail.com.
authors.forename: Lenka
authors.initials: L
authors.lastname: Starýchová
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Marián
authors.initials: M
authors.lastname: Žabka
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Špaglová
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Mária
authors.initials: M
authors.lastname: Čuchorová
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Mária
authors.initials: M
authors.lastname: Vitková
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Martina
authors.initials: M
authors.lastname: Čierna
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Kamila
authors.initials: K
authors.lastname: Bartoníková
authors.affiliation: Department of Galenic PharmacyFaculty of PharmacyComenius University in BratislavaBratislava832 32Slovakia.
authors.forename: Klára
authors.initials: K
authors.lastname: Gardavská
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D004655:Emulsions; D005782:Gels; D013501:Surface-Active Agents; D012967:Sodium Dodecyl Sulfate; D048271:Chitosan; D007213:Indomethacin
keywords: chitosan; dissolution; drug delivery; gels; microemulsion; permeation enhancers; semi-solids; surfactants