title: Genetic association between the HIF-1α P582S polymorphism and cervical cancer risk: a meta analysis.
abstract: BACKGROUND
  Hypoxia-inducible factor-1 alpha (HIF-1α) P582S polymorphism has been reported to increase transactivation capacity of HIF-1α, which is prone to tumorigenesis. Several published case-control studies on the association between P582S polymorphism and cervical cancer have shown mixed results. In this study, we chose to perform a meta-analysis to assess the association.
  
  
  RESULTS
  We conducted a meta-analysis consisting of four studies with a total of 846 cases and 991 controls. All data were collected and overall comparison was performed among all subjects. Using the fixed effects model, the homozygous and the recessive models showed a significant increase in the risk of cervical cancer (the pooled OR=6.32, 95% CI=2.28-17.55, Phet=0.348; the pooled OR=5.86, 95% CI=2.13-16.11, Phet=0.394 respectively). Publication bias was not significantly indicated in this analysis.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that HIF-1α P582S polymorphism may be associated with the risk of cervical cancer.
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cheng
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Rongkai
authors.initials: R
authors.lastname: Xie
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Zhengqiong
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Youfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Guilan
authors.initials: G
authors.lastname: Lin
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Jianmei
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Gynaecology and Obstetrics, Xinqiao Hospital, Third Military Medical University Chongqing 400037, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D016014:Linear Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D018570:Risk Assessment; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: HIF-1α; cervical cancer; polymorphism; risk