title: Patient with neuromyelitis optica spectrum disorder combined with Sjögren's syndrome relapse free following tacrolimus treatment.
abstract: Tacrolimus, a novel immunosuppressant agent, has been widely used in organ transplantation and autoimmune diseases. We herein present a case of neuromyelitis optica spectrum disorder (NMOSD) combined with Sjögren's syndrome (SS) successfully treated with tacrolimus. This patient repeatedly presented with recurrent longitudinally extensive transverse myelitis. Her NMO-IgG and anti-SSA and anti-SSB antibodies were seropositive. Considering the frequency of relapses and severe disability, tacrolimus was initiated after failure of intravenous cyclophosphamide. Her status was steady for over 36 months after tacrolimus treatment. This report indicates that tacrolimus may be a potentially effective immunosuppressant for NMOSD with systemic autoimmune diseases.
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, China.
authors.forename: Xueping
authors.initials: X
authors.lastname: Zheng
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Liu
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Mu
authors.forename: Wenru
authors.initials: W
authors.lastname: Yang
authors.forename: Youxin
authors.initials: Y
authors.lastname: Liu
authors.forename: Ping
authors.initials: P
authors.lastname: Ge
authors.forename: Haifeng
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000276:immunology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local; D009471:Neuromyelitis Optica / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D012859:Sjogren's Syndrome / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D016559:Tacrolimus