title: Transcriptional dysregulation of γ-aminobutyric acid transporter in parvalbumin-containing inhibitory neurons in the prefrontal cortex in schizophrenia.
abstract: Parvalbumin (PV)-containing neurons are functionally compromised in schizophrenia. Using double in situ hybridization in postmortem human prefrontal cortex, we found that the messenger RNA (mRNA) for the γ-aminobutyric acid (GABA) transporter GAT-1 was undetectable in 22-41% of PV neurons in layers 3-4 in schizophrenia. In the remaining PV neurons with detectable GAT-1 mRNA, transcript expression was decreased by 26% in layer 3. Hence, the dysfunction of PV neurons involves the molecular dysregulation of presynaptic GABA reuptake.
authors.affiliation: System and Cell Biology of Neurodegeneration, University of Zürich, Zürich, Switzerland; Program in Cellular Neuropathology, McLean Hospital, Belmont, MA, USA.
authors.forename: Byron K Y
authors.initials: BK
authors.lastname: Bitanihirwe
authors.affiliation: Program in Cellular Neuropathology, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: wwoo@hms.harvard.edu.
authors.forename: Tsung-Ung W
authors.initials: TU
authors.lastname: Woo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D050485:GABA Plasma Membrane Transport Proteins / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000235:genetics* / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism*; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology*; D012333:RNA, Messenger / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D050485:GABA Plasma Membrane Transport Proteins; D010320:Parvalbumins; D012333:RNA, Messenger; D005680:gamma-Aminobutyric Acid
keywords: Parvalbumin; Schizophrenia; γ-aminobutyric acid transporter-1