title: Clinical applicability of multi-tumor marker protein chips for diagnosing ovarian cancer.
abstract: OBJECTIVE
  To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer.
  
  
  METHODS
  Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, β-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects.
  
  
  RESULTS
  The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01.
  
  
  CONCLUSIONS
  Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.
authors.affiliation: Department of Laboratory The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China E-mail : shallyvans@163.com, shallyvans@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Bian
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Xian-Juan
authors.initials: XJ
authors.lastname: Kou
authors.forename: Xu-Na
authors.initials: XN
authors.lastname: Wang
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Sun
authors.forename: Liang
authors.initials: L
authors.lastname: Ming
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000378:metabolism; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D018284:Cystadenocarcinoma, Serous / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D040081:Protein Array Analysis / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor