title: Label-free detection of DNA by combining gated mesoporous silica and catalytic signal amplification of platinum nanoparticles.
abstract: This article presents a simple label-free detection of nucleic acids by using Pt@mesoporousSiO2 as a "smart" reporter, whose pores are first capped by single-stranded (ss) probe DNA. The detection signal is then amplified using the TMB oxidation reaction catalysed by Pt NPs while hybridizing with the complementary ss target DNA, which makes the pores of mesoporous SiO2 open through hybridization.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, China. zfwang@seu.edu.cn.
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Wang
authors.forename: Xia
authors.initials: X
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Yongjun
authors.initials: Y
authors.lastname: Tang
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Nongyue
authors.initials: N
authors.lastname: He
mesh_terms: D002384:Catalysis; D004247:DNA / Q000737:chemistry* / Q000302:isolation & purification*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D010984:Platinum / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D010984:Platinum; D012822:Silicon Dioxide; D004247:DNA