title: Emerging scrub typhus infection in the northern region of Sri Lanka.
abstract: BACKGROUND
  There is an increasing trend in rickettsioses or typhus fevers in the island of Sri Lanka. The seroepidemiological mapping previously published did not include the northern region of the island. This study was conducted to demonstrate the presence of scrub typhus (ST) and to characterise the clinical presentation of ST in this region.
  
  
  RESULTS
  Serum samples from patients (n = 64) with clinical symptoms suspected of typhus fever following exclusion of other common febrile illnesses commonly seen in the northern region of Sri Lanka were selected and screened for ST using specific IgM and IgG ELISA (ImBios, USA). ST was confirmed by serology in 54 patients, with typical eschar being found in 49 of cases positive for ST. Fever was the sole presenting complaint of these patients with the duration of febrile illness varying from 2-14 days. Of these patients 44.4% had regional lymphadenopathy, 18.5% hepatomegaly, 12.9% pneumonitis and 9.3% splenomegaly. None of the patients had a rash.
  
  
  CONCLUSIONS
  This study confirms the presence of high numbers of patients with ST in northern Sri Lanka. It was found that 84.4% of the patients presenting with clinical features of rickettsioses (54 of the 64) were seropositive for ST with a significant majority having a typical eschar. This data provided will enable clinicians to be vigilant of ST in this region and provide appropriate therapy and also facilitate planning for preventive measures aimed at reducing the burden of ST.
authors.forename: Jebananthy Anandaselvam
authors.initials: JA
authors.lastname: Pradeepan
authors.forename: Natkunam
authors.initials: N
authors.lastname: Ketheesan
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Jaffna, Jaffna, Sri Lanka. kalamathy6@gmail.com.
authors.forename: Kalamathy
authors.initials: K
authors.lastname: Murugananthan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D012612:Scrub Typhus / Q000097:blood / Q000453:epidemiology*; D013188:Sri Lanka / Q000453:epidemiology