title: Fat embolism syndrome after femur fracture fixation: a case report.
abstract: Fat embolism syndrome (FES) is a multi-organ disorder with potentially serious sequelae that is commonly seen in the orthopaedic patient population after femur fractures. The major clinical features of FES include hypoxia, pulmonary dysfunction, mental status changes, petechiae, tachycardia, fever, thrombocytopenia, and anemia. Due to technological advances in supportive care and intramedullary reaming techniques, the incidence of FES has been reported as low as 0.5 percent. Here, we present a rare case of FES with cerebral manifestations. A previously healthy 24-year old nonsmoking male was admitted to our hospital after an unrestrained head-on motor vehicle collision. The patient's injuries included a left olecranon fracture and closed bilateral comminuted midshaft femur fractures. The patient went on to develop cerebral fat embolism syndrome (CFES) twelve hours after immediate bilateral intramedullary nail fixation. His symptoms included unresponsiveness, disconjugate gaze, seizures, respiratory distress, fever, anemia, thrombocytopenia, and visual changes. Head computed tomography and brain magnetic resonance imaging showed pathognomonic white-matter punctate lesions and watershed involvement. With early recognition and supportive therapy and seizure therapy, the patient went on to have complete resolution of symptoms without cognitive sequelae.
authors.affiliation: University of Iowa Hospitals and Clinics Department of Orthopaedics and Rehabilitation.
authors.forename: Craig C
authors.initials: CC
authors.lastname: Akoh
authors.affiliation: University of Iowa Hospitals and Clinics Department of Orthopaedics and Rehabilitation.
authors.forename: Cameron
authors.initials: C
authors.lastname: Schick
authors.affiliation: University of Iowa Hospitals and Clinics Department of Orthopaedics and Rehabilitation.
authors.forename: Jesse
authors.initials: J
authors.lastname: Otero
authors.affiliation: University of Iowa Hospitals and Clinics Department of Orthopaedics and Rehabilitation.
authors.forename: Matthew
authors.initials: M
authors.lastname: Karam
mesh_terms: D001921:Brain / Q000473:pathology; D004620:Embolism, Fat / Q000209:etiology* / Q000473:pathology; D005264:Femoral Fractures / Q000601:surgery*; D005334:Fever / Q000209:etiology* / Q000473:pathology; D005592:Fracture Fixation / Q000009:adverse effects*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012640:Seizures / Q000209:etiology* / Q000473:pathology; D013577:Syndrome; D013921:Thrombocytopenia / Q000209:etiology* / Q000473:pathology; D055815:Young Adult