title: Improved analytical performance of negative 63Ni ion mobility spectrometry for on-line measurement of propofol using dichloromethane as dopant.
abstract: On-line monitoring of propofol in exhaled air is a potential way to evaluate the anaesthesia depth for patients during surgery. In this study, a negative (63)Ni ionization high resolution ion mobility spectrometer with Bradbury-Nielsen-Gate-Grid structure was built to measure propofol with reactant ions Cl(-)(H2O) n using dichloromethane as dopant. Instead of forming three propofol ions (M - H)(-), M · O2(-), and (M2 - H)(-) with reactant ions O2(-)(H2O)n, only product ion M · Cl(-) was produced when introducing dichloromethane gas. The peak-to-peak resolution (R p-p) between reactant ions Cl(-)(H2O)n and product ion M · Cl(-) was 17.4, which was 1.6 times larger than that between O2(-)(H2O)n and product ion. Furthermore, the linear response range using reactant ions Cl(-)(H2O)n was 3.5 times wider than that obtained with reactant ions O2(-)(H2O)n.
authors.affiliation: Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Hua
authors.forename: Changsong
authors.initials: C
authors.lastname: Wang
authors.forename: Enyou
authors.initials: E
authors.lastname: Li
authors.forename: Haiyang
authors.initials: H
authors.lastname: Li
mesh_terms: D007477:Ions / Q000032:analysis / Q000737:chemistry; D013058:Mass Spectrometry / Q000592:standards; D008752:Methylene Chloride / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D015742:Propofol / Q000032:analysis* / Q000737:chemistry*; D011868:Radioisotopes / Q000737:chemistry*
chemical_list: D007477:Ions; D011868:Radioisotopes; D008752:Methylene Chloride; D009532:Nickel; D015742:Propofol