title: Association between interleukin-8 -251A/T polymorphism and risk of lung cancer: a meta-analysis.
abstract: This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associated with a significantly increased risk of lung cancer in all genetic models. However, stratified by ethnicity, a significantly increased risk was found among Asians. In conclusion, IL-8 -251A/T polymorphism is associated with lung cancer susceptibility in Asians and the -251 A allele may increase risk of lung cancer in Asians.
authors.affiliation: Oncology Department, Chinese PLA General Hospital, Beijing, China,1.
authors.forename: Ping
authors.initials: P
authors.lastname: Gao
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Junhao
authors.initials: J
authors.lastname: You
authors.forename: Fangfang
authors.initials: F
authors.lastname: Jing
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000225:Adenine / Q000378:metabolism*; D044466:Asian People / Q000235:genetics*; D019295:Computational Biology / Q000379:methods; D016206:Databases, Bibliographic; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008175:Lung Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013941:Thymine / Q000378:metabolism*
chemical_list: C508606:CXCL8 protein, human; D016209:Interleukin-8; D000225:Adenine; D013941:Thymine
keywords: Interleukin-8; Lung cancer; Meta-analysis; Polymorphism