title: Bactericidal activity of selected medicinal plants against multidrug resistant bacterial strains from clinical isolates.
abstract: OBJECTIVE
  To investigate the antibacterial effect of Curcuma longa (C. longa), Zingiber officinale (Z. officinale) and Tinospora cordifolia (T. cordifolia) against Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Bacillus subtilis and Proteus mirabilis of clinical origin.
  
  
  METHODS
  The antimicrobial efficacy of said medicinal plants and establishment of multidrug resistant character of these bacteria were carried out using disc diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods.
  
  
  RESULTS
  The results of MIC and MBC showed that these clinical bacterial isolates were phenotypically multidrug resistant against standard antibiotics (>500 μg/mL). Compared to standard antibiotics, C. longa, Z. officinale and T. cordifolia were more effective in killing these microbes as evident from MIC and MBC values (5 to 125 μg/mL). Moreover, C. longa had highest antibacterial efficacy compared to Z. officinale and T. cordifolia.
  
  
  CONCLUSIONS
  The result thus obtained suggests that bioactive principles of these plants can be used particularly against these multidrug resistant bacteria of clinical origin.
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India.
authors.forename: Biswajit
authors.initials: B
authors.lastname: Chakraborty
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Nath
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India.
authors.forename: Himadri
authors.initials: H
authors.lastname: Saikia
authors.affiliation: Department of Biotechnology, Assam University, Silchar, Assam 788011, India. Electronic address: senguptamahuya35@gmail.com.
authors.forename: Mahuya
authors.initials: M
authors.lastname: Sengupta
keywords: Bactericidal; Clinical origin; MIC and MBC; Medicinal plants