title: PET imaging of bacterial infections with fluorine-18-labeled maltohexaose.
abstract: A positron emission tomography (PET) tracer composed of (18)F-labeled maltohexaose (MH(18)F) can image bacteria in vivo with a sensitivity and specificity that are orders of magnitude higher than those of fluorodeoxyglucose ((18)FDG). MH(18)F can detect early-stage infections composed of as few as 10(5) E. coli colony-forming units (CFUs), and can identify drug resistance in bacteria in vivo. MH(18)F has the potential to improve the diagnosis of bacterial infections given its unique combination of high specificity and sensitivity for bacteria.
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Xinghai
authors.initials: X
authors.lastname: Ning
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University (USA).
authors.forename: Wonewoo
authors.initials: W
authors.lastname: Seo
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Seungjun
authors.initials: S
authors.lastname: Lee
authors.affiliation: Division of Cardiology, Department of Medicine, Emory University School of Medicine (USA).
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Takemiya
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Mohammad
authors.initials: M
authors.lastname: Rafi
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Xuli
authors.initials: X
authors.lastname: Feng
authors.affiliation: Division of Cardiology, Department of Medicine, Emory University School of Medicine (USA).
authors.forename: Daiana
authors.initials: D
authors.lastname: Weiss
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Xiaojian
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University (USA).
authors.forename: Larry
authors.initials: L
authors.lastname: Williams
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University (USA).
authors.forename: Vernon M
authors.initials: VM
authors.lastname: Camp
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University (USA).
authors.forename: Malveaux
authors.initials: M
authors.lastname: Eugene
authors.affiliation: Division of Cardiology, Department of Medicine and the Department of Biomedical Engineering, Emory University School of Medicine and the Atlanta VA Medical Center (USA).
authors.forename: W Robert
authors.initials: WR
authors.lastname: Taylor
authors.affiliation: Department of Radiology and Imaging Sciences, Emory University (USA).
authors.forename: Mark
authors.initials: M
authors.lastname: Goodman
authors.affiliation: Department of Bioengineering, UC Berkeley, 284 Hearst Memorial Mining Building, UC Berkeley, Berkeley, CA 94720 (USA).
authors.forename: Niren
authors.initials: N
authors.lastname: Murthy
mesh_terms: D000818:Animals; D004927:Escherichia coli Infections / Q000175:diagnosis* / Q000188:drug therapy; D005462:Fluorine Radioisotopes / Q000737:chemistry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry; D049268:Positron-Emission Tomography; D051381:Rats
chemical_list: D005462:Fluorine Radioisotopes; D009844:Oligosaccharides; C016549:maltohexaose
keywords: bacterial infections; maltodextrin transporters; maltohexaose; positron emission tomography; radiochemistry