title: An effective method for improving outcomes in patients with a fertilization defect.
abstract: The effect of artificial oocyte activation (AOA) with a calcium ionophore on intracytoplasmic morphologically selected sperm injection (IMSI) was examined in patients with histories of repeated failed implantation attempts. Four singleton pregnancies and one twin pregnancy were obtained after embryos transfer (5/14, 35.7%). Therefore, AOA combined with IMSI can be considered an option for cycles with a fertilization defect and recurrent implantation failures.
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Yoon
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: Hyung Jun
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: In Hee
authors.initials: IH
authors.lastname: Bae
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Chae
authors.affiliation: Maria Research Center, Seoul, Korea.
authors.forename: San Hyun
authors.initials: SH
authors.lastname: Yoon
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: Won Don
authors.initials: WD
authors.lastname: Lee
authors.affiliation: Maria Reproductive Center, Department of Obstetrics and Gynecology, Maria Fertility Hospital, Seoul, Korea.
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Lim
keywords: Artificial oocyte activation; Intracytoplasmic morphologically selected sperm injection; Recurrent implantation failures