title: [Effect of nasal instillation of vitamin D3 on patient with allergic rhinitis symptoms].
abstract: OBJECTIVE
  To investigate the effect of nasal instillation of vitamin D3 on patients with allergic rhinitis symptoms including nasal itching, sneezing, clear nasal discharge, and nasal congestion.
  
  
  METHODS
  Thirty subjects with allergic rhinitis proved by skin prick test (SPT) and 30 subjects with deviated septum alone were recrui ted and administrated with 300 000 IU of vitamin D3 by nasal instillation weekly. Seven days after the intervention, the four major symptoms including nasal itching, sneezing, clear nasal discharge, and nasal congestion were evaluated by score.
  
  
  RESULTS
  After intranasal instillation of vitamin D3, the symptoms in allergic rhinitis group in cluding nasal itching, sneezing, nasal discharge and nasal congestion, and serum 25-hydroxyvitamin D level has statistical differences (P < 0.05).
  
  
  CONCLUSIONS
  Vitamin D3 could be well absorbed through nasal mucosa. It demonstrated to have significantly effect on serum 25-hydroxyvitamin D to improve the symptoms for patients with allergic rhinitis. Vitamin D3 may be a kind of adjuvant therapy for prevention and treatment of allergic rhinitis.
authors.forename: Weiqun
authors.initials: W
authors.lastname: Gong
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Feng
authors.forename: Ping
authors.initials: P
authors.lastname: Yan
authors.forename: Shuijun
authors.initials: S
authors.lastname: Li
authors.forename: Chen
authors.initials: C
authors.lastname: Yu
authors.forename: Xueying
authors.initials: X
authors.lastname: Zhou
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Xiabin
authors.initials: X
authors.lastname: Ren
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Yongfeng
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D002762:Cholecalciferol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D065631:Rhinitis, Allergic / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D002762:Cholecalciferol