title: Hepatitis a virus infection-associated hemophagocytic lymphohistiocytosis in two children.
abstract: Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by high fever, maculopapular rash, neurological symptoms, abnormal liver functions and coagulopathy. Primary HLH is due to an underlying genetic abnormality. Secondary HLH are due to an underlying infection, autoimmune disease or malignancy. Secondary HLH due to viral infections are commonly due to the herpes group commonest of which is the Ebstein Barr virus (EBV). We describe two children with virus associated hemophagocytic lymphohistiocytosis (VAHLH) secondary to hepatitis A infection.
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Kirubakaran
authors.initials: K
authors.lastname: Navamani
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Manivachagan Muthappa
authors.initials: MM
authors.lastname: Natarajan
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Arul Premanand
authors.initials: AP
authors.lastname: Lionel
authors.affiliation: Department of Paediatrics, Christian Medical College, Vellore, 632004 India.
authors.forename: Sathish
authors.initials: S
authors.lastname: Kumar