title: Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.
abstract: Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofluorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway.
authors.affiliation: Department of Cancer, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China ; Division of Health, Bureau of Guard, General Advisor Office of Chinese PLA, Beijing 100017, China.
authors.forename: Yinghuan
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Medical Department, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Bao
authors.affiliation: Department of Cancer, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China.
authors.forename: Chenghao
authors.initials: C
authors.lastname: Li
authors.affiliation: Division of Health, Bureau of Guard, General Advisor Office of Chinese PLA, Beijing 100017, China.
authors.forename: Fubin
authors.initials: F
authors.lastname: Jiao
authors.affiliation: Medical Department, the 463 Hospital of Chinese PLA, Shenyang 110042, Liaoning Province, China.
authors.forename: Hongjie
authors.initials: H
authors.lastname: Xin
authors.affiliation: Key Laboratory of Health Ministry for Congenital Malformation, Shengjing Hospital, China Medical University, Shenyang 110004, Liaoning Province, China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: Yuan
keywords: apoptotic kinase; c-Jun N-terminal kinase; caspase-3; mitogen-activated protein kinase; myeloid tissues; neural development; neural regeneration; neural tube defects; regeneration; retinoic acid