title: Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy.
abstract: A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.
authors.affiliation: Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea.
authors.forename: So Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Hyun Su
authors.initials: HS
authors.lastname: Min
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Ku
authors.forename: Sohee
authors.initials: S
authors.lastname: Son
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.forename: Sun Hwa
authors.initials: SH
authors.lastname: Kim
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D015316:Genetic Therapy; D006367:HeLa Cells; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D051379:Mice; D018613:Microscopy, Confocal; D008970:Molecular Weight; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D010539:Permeability; D010778:Photochemotherapy; D034741:RNA, Small Interfering / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D034741:RNA, Small Interfering; D012709:Serum Albumin; C118638:glycol-chitosan; D048271:Chitosan
keywords: EPR; amphiphilic nanoparticles; cancer therapy; diagnosis; glycol chitosan