title: Evaluation of anti-inflammatory activity of probiotic on carrageenan-induced paw edema in Wistar rats.
abstract: OBJECTIVE
  Probiotic strain Lactobacillus sporogenes and Bifidobacteria bifidum were used to assess the anti-inflammatory properties in Carrageenan induced acute inflammatory model.
  
  
  METHODS
  Non-encapsulated and encapsulated Probiotic strain of Bifidobacteria bifidum and Lactobacillus sporogenes was given orally. Diclofenac sodium was used as standard drug at a concentration of 150 mg/kg of body weight. Edema was induced with 1% carrageenan to all the groups except group A after half an hour of the oral treatments. Paw thickness was checked at t = 1, 2, 4 and 24 h. Stair climbing score and motility score were assessed at t = 24 h.
  
  
  RESULTS
  Non-encapsulated and encapsulated Probiotic Bifidobacteria and Lactobacillus showed a statistically significant decrease in paw thickness at P < 0.05. The percentage inhibition in paw thickness of non-encapsulated and encapsulated probiotic L. sporogenes and B. bifidum is 37 ± 3% and 43 ± 2% after 24 h of treatment. They both significantly increased stair climbing and motility score.
  
  
  CONCLUSIONS
  Probiotic B. bifidum and L. sporogenes significantly decreased the inflammatory reactions induced by carrageenan.
authors.forename: Himanshu K
authors.initials: HK
authors.lastname: Solanki
authors.forename: Dushyant A
authors.initials: DA
authors.lastname: Shah
authors.forename: Pankaj M
authors.initials: PM
authors.lastname: Maheriya
authors.forename: Chirag A
authors.initials: CA
authors.lastname: Patel
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy*; D005121:Extremities / Q000473:pathology*; D007249:Inflammation / Q000473:pathology; D008124:Locomotion / Q000187:drug effects; D019936:Probiotics / Q000494:pharmacology / Q000627:therapeutic use*; D017208:Rats, Wistar
chemical_list: D000893:Anti-Inflammatory Agents; D002351:Carrageenan