title: Levothyroxine improves subjective sleepiness in a euthyroid patient with narcolepsy without cataplexy.
abstract: OBJECTIVE
  We discuss the use of levothyroxine for excessive daytime sleepiness (EDS) and prolonged nocturnal sleep time in a euthyroid patient with narcolepsy.
  
  
  METHODS
  After failure of first-line narcolepsy treatments, a 48-year-old female began levothyroxine (25 mcg/day). After 12 weeks of treatment, the patient was evaluated for improvement in total sleep time and subjective daytime sleepiness assessed by Epworth Sleepiness Scale (ESS).
  
  
  RESULTS
  At baseline, ESS score was 16 and total sleep time averaged 16 h/day. After 12 weeks, ESS was 13 and reported total sleep time was 13 h/day.
  
  
  CONCLUSIONS
  Levothyroxine improved EDS and total sleep time in a euthyroid patient with narcolepsy without cataplexy after 12 weeks without side effects.
authors.affiliation: Duke University School of Medicine, Durham, NC.
authors.forename: Danielle L
authors.initials: DL
authors.lastname: Sobol
authors.affiliation: Duke University School of Medicine, Durham, NC.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Spector
mesh_terms: D002375:Catalepsy; D006970:Disorders of Excessive Somnolence / Q000175:diagnosis / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009290:Narcolepsy / Q000175:diagnosis* / Q000188:drug therapy*; D017286:Polysomnography / Q000379:methods; D012016:Reference Values; D012720:Severity of Illness Index; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000502:physiology; D013974:Thyroxine / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D013974:Thyroxine
keywords: excessive daytime sleepiness; levothyroxine; narcolepsy