title: Circulating MiR-133a as a biomarker predicts cardiac hypertrophy in chronic hemodialysis patients.
abstract: BACKGROUND
  MicroRNAs (miRNAs) are small ribonucleotides regulating gene expression. MicroRNAs are present in the blood in a remarkably stable form and have emerged as potential diagnostic markers in patients with cardiovascular disease. Our study aimed to assess circulating miR-133a levels in MHD patients and the relation of miR-133a to cardiac hypertrophy.
  
  
  METHODS
  We profiled miRNAs using RNA isolated from the plasma of participants. The results were validated in 64 MHD patients and 18 healthy controls.
  
  
  RESULTS
  Levels of plasma miR-133a decreased in MHD patients with LVH compared with those in healthy controls. Plasma miR-133a concentrations were negatively correlated with LVMI and IVS. After single hemodialytic treatment, plasma miR-133a levels remained unchanged. Cardiac Troponin I and T were not associated with LVMI and IVS.
  
  
  CONCLUSIONS
  Our observations supplied the possibility that circulating miR-133a could be a surrogate biomarker of cardiac hypertrophy in MHD patients.
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Wen
authors.affiliation: Department of Nephrology, Affiliated Wuxi Hospital, Nanjing Medical University, Wuxi, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Song
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ye
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Wu
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Tang
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Fang
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Hongdi
authors.initials: H
authors.lastname: Cao
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Weichun
authors.initials: W
authors.lastname: He
authors.affiliation: Department of Radiology, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Yafang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Chunsun
authors.initials: C
authors.lastname: Dai
authors.affiliation: Center for Kidney Disease, Second Affiliated Hospital, Nanjing Medical University, Nanjing, China.
authors.forename: Junwei
authors.initials: J
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D006332:Cardiomegaly / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D006435:Renal Dialysis; D019210:Troponin I / Q000378:metabolism; D020107:Troponin T / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; C548234:MIRN133 microRNA, human; D035683:MicroRNAs; D019210:Troponin I; D020107:Troponin T