title: Family patterns of psychopathology in psychiatric disorders.
abstract: OBJECTIVE
  Familial loading and crucial outcomes of family history of psychopathology in psychiatric disorders have long been recognized. There has been ample literature providing convincing evidence for the importance of family psychopathology in development of emotional disturbances in children as well as worse outcomes in the course of psychiatric disorders. More often, maternal psychopathology seems to have been an issue of interest rather than paternal psychopathology while effects of second-degree familiality have received almost no attention. In this study, we addressed the relations between affected first- and second-degree relatives of probands and categories of psychiatric disorders.
  
  
  METHODS
  Subjects were 350 hospitalized psychiatric inpatients, consecutively admitted to psychiatry clinics in Van, Turkey. Mean age was 34.16 (SD±12) and 51.4% of the sample consisted of male patients. Assessment of psychopathology in psychiatric probands was conducted based on DSM-IV TR. Familial loading of psychiatric disorders amongst first- and second-degree relatives of patients were initially noted primarily relying on patients' retrospective reports, and confirmed by both phone call and following official health records via the Medical Knowledge System. We analyzed the data using latent class analysis approach.
  
  
  RESULTS
  We found four patterns of familial psychopathology. Latent homogeneous subsets of patients due to familial characteristics were as paternal kinship psychopathology with schizophrenia, paternal kinship psychopathology with mood disorders, maternal kinship psychopathology and core family psychopathology.
  
  
  CONCLUSIONS
  Family patterns were critical to exerting variation in psychiatric disorders of probands and affected relatives. Probands with a core family pattern of psychopathology exhibited the most colorful clinical presentations in terms of variation in psychopathology. We observed a specificity of intergenerational transmission of psychiatric disorders when family patterns of psychopathology were taken into consideration, even second-degree relatives of psychiatric probands.
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University, Van, Turkey. Electronic address: drosmanozdemir@yahoo.com.
authors.forename: Osman
authors.initials: O
authors.lastname: Özdemir
authors.affiliation: Department of Psychology, Faculty of Art, Yuzuncu Yil University, Van, Turkey. Electronic address: boysan.murat@gmail.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Boysan
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University, Van, Turkey. Electronic address: pguzelozdemir@yahoo.com.
authors.forename: Pınar Güzel
authors.initials: PG
authors.lastname: Özdemir
authors.affiliation: Department of Medical Genetics, Dicle University, Diyarbakır, Turkey. Electronic address: scoskun9@gmail.com.
authors.forename: Salih
authors.initials: S
authors.lastname: Coşkun
authors.affiliation: Department of Psychiatry, Atatürk University, Erzurum, Turkey. Electronic address: halilozcan23@yahoo.com.
authors.forename: Halil
authors.initials: H
authors.lastname: Özcan
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University, Van, Turkey. Electronic address: ekrem.yilmaz.84@hotmail.com.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Yılmaz
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University, Van, Turkey. Electronic address: ercan_atilla72@hotmail.com.
authors.forename: Ercan
authors.initials: E
authors.lastname: Atilla
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004198:Disease Susceptibility; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D014421:Turkey; D055815:Young Adult