title: IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours.
abstract: IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was significantly reduced in IL1RAPL1 knockout mice. The spatial reference and working memories and remote fear memory were mildly impaired in IL1RAPL1 knockout mice. Furthermore, the behavioural flexibility was slightly reduced in the T-maze test. Interestingly, the performance of IL1RAPL1 knockout mice in the rotarod test was significantly better than that of wild-type mice. Moreover, IL1RAPL1 knockout mice consistently exhibited high locomotor activity in all the tasks examined. In addition, open-space and height anxiety-like behaviours were decreased in IL1RAPL1 knockout mice. These results suggest that IL1RAPL1 ablation resulted in spine density decrease and affected not only learning but also behavioural flexibility, locomotor activity and anxiety.
authors.affiliation: 1] Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan [2] Liaison Academy, School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
authors.forename: Misato
authors.initials: M
authors.lastname: Yasumura
authors.affiliation: 1] Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan [2] Department of Molecular Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Toyama, Japan [3] PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
authors.forename: Maya
authors.initials: M
authors.lastname: Yamazaki
authors.affiliation: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Abe
authors.affiliation: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
authors.forename: Rie
authors.initials: R
authors.lastname: Natsume
authors.affiliation: Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
authors.forename: Kouta
authors.initials: K
authors.lastname: Kanno
authors.affiliation: 1] Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan [2] Department of Molecular and Cellular Physiology, Shinsyu University School of Medicine, Matsumoto, Nagano, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Uemura
authors.affiliation: Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physical Sciences, Okazaki, Aichi, Japan.
authors.forename: Keizo
authors.initials: K
authors.lastname: Takao
authors.affiliation: Department of Cellular Neurobiology, Brain Research Institute, Niigata University, Niigata, Niigata, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakimura
authors.affiliation: Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kikusui
authors.affiliation: 1] Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physical Sciences, Okazaki, Aichi, Japan [2] Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyakawa
authors.affiliation: 1] Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan [2] Brain Science Laboratory, The Research Organization of Science and Technology, Ritsumeikan University, Kusatsu, Shiga, Japan.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mishina
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D053577:Interleukin-1 Receptor Accessory Protein / Q000235:genetics*; D007858:Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000235:genetics* / Q000502:physiology; D013131:Spine / Q000473:pathology
chemical_list: D053577:Interleukin-1 Receptor Accessory Protein; C568303:interleukin-1 receptor accessory protein-like 1, mouse