title: Oligostilbenoids with acetylcholinesterase inhibitory activity from Dipterocarpus alatus.
abstract: Phytochemical investigation of the stem wood of Dipterocarpus alatus led to the isolation and characterization of four new oligostilbenoids, dipterocarpols A-D (1-4), together with two known resveratrol oligomers, hopeahainol (5) and hopeafuran (6). The structures of the new compounds were determined by comprehensive spectral analysis including 1D and 2D NMR, and high-resolution MS. The absolute configurations were determined by NOESY and CD spectra. Dipterocarpol A (1) and hopeahainol A (5) showed moderate acetylcholinesterase inhibitory activity with IC50 values of 8.28 µM and 11.28 µM, respectively. Furthermore, the discovery of compound 3 gave the first evidence that the biosynthetic origin of resveratrol aneuploids is related to the loss of a half resveratrol unit by oxidative cleavage.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Chao Jun
authors.initials: CJ
authors.lastname: Chen
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Rui Hua
authors.initials: RH
authors.lastname: Jiao
authors.affiliation: Department of Chemistry, Faculty of Science, Kasetsart University and Center of Nanotechnology, Kasetsart University, Bangkok, Thailand.
authors.forename: Chompoonuch
authors.initials: C
authors.lastname: Tancharoen
authors.affiliation: Interdisciplinary Graduate Program in Genetic Engineering, The Graduate School, Kasetsart University, Bangkok, Thailand.
authors.forename: Kanokorn
authors.initials: K
authors.lastname: Sudto
authors.affiliation: Department of Botany, Faculty of Science, Kasetsart University, Bangkok, Thailand.
authors.forename: Sranya
authors.initials: S
authors.lastname: Vajarothai
authors.affiliation: Department of Chemistry, Faculty of Science, Kasetsart University and Center of Nanotechnology, Kasetsart University, Bangkok, Thailand.
authors.forename: Supa
authors.initials: S
authors.lastname: Hannongbua
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D053958:Dipterocarpaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D013267:Stilbenes; D000077185:Resveratrol