title: [Study of collagen sponge extracts on mouse splenic lymphocyte transformation in vitro].
abstract: Immunogenicity for medical devices of animal origin is the key and difficult point during immune safety evaluation for these devices. This paper firstly investigated the effect of collagen sponge of animal origin on mouse splenic lymphocyte transformation and proliferation, and then analyzed the influence factors on the MTT method and CFSE method. The results showed that collagen sponge extract cannot significantly induce transformation and proliferation of mouse splenic lymphocyte in vitro.
authors.forename: Shifu
authors.initials: S
authors.lastname: Wu
authors.forename: Chenghu
authors.initials: C
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Hou
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Sun
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Gai
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shi
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D011161:Porifera / Q000737:chemistry; D013154:Spleen / Q000166:cytology*
chemical_list: D003094:Collagen