title: Recent development in [1,4]benzodiazepines as potent anticancer agents: a review.
abstract: The [1,4]benzodiazepine is an important class of heterocyclic compounds and clinically used for many ailments in humans. The [1,4]benzodiazepine has unique structure that mimics the peptide linkage. This interesting observation completely shifted the interest of medicinal chemist for [1,4]benzodiazepine from CNS acting drugs to anticancer agents. During last few decades, a large number of reports have appeared in the literature highlighting the anticancer activity of [1,4]benzodiazepines. Here, in this article, we have discussed the brief synthesis, origin of [1,4]benzodiazepines as anticancer agent, their mechanism of action and latest developments in this field. We have compiled the most important literature reports from last few decades till date.
authors.forename: Rupinder Kaur
authors.initials: RK
authors.lastname: Gill
authors.forename: Shiv Om
authors.initials: SO
authors.lastname: Kaushik
authors.forename: Jasreen
authors.initials: J
authors.lastname: Chugh
authors.forename: Sumit
authors.initials: S
authors.lastname: Bansal
authors.forename: Anamik
authors.initials: A
authors.lastname: Shah
authors.affiliation: Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga-142001, Punjab, India. jitender.bariwal@gmail.com.
authors.forename: Jitender
authors.initials: J
authors.lastname: Bariwal
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007364:Intercalating Agents; D001569:Benzodiazepines; D004247:DNA