title: Facilitated diffusion buffers noise in gene expression.
abstract: Transcription factors perform facilitated diffusion [three-dimensional (3D) diffusion in the cytosol and 1D diffusion on the DNA] when binding to their target sites to regulate gene expression. Here, we investigated the influence of this binding mechanism on the noise in gene expression. Our results showed that, for biologically relevant parameters, the binding process can be represented by a two-state Markov model and that the accelerated target finding due to facilitated diffusion leads to a reduction in both the mRNA and the protein noise.
authors.affiliation: Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom and Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom.
authors.forename: Armin P
authors.initials: AP
authors.lastname: Schoech
authors.affiliation: Cambridge Systems Biology Centre, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom and Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom.
authors.forename: Nicolae Radu
authors.initials: NR
authors.lastname: Zabet
mesh_terms: D002021:Buffers; D055459:Facilitated Diffusion; D005786:Gene Expression Regulation; D056968:Lac Repressors / Q000235:genetics; D008957:Models, Genetic; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D002021:Buffers; D056968:Lac Repressors; D014157:Transcription Factors