title: [Cereblon -  a new target of therapy in the treatment of multiple myeloma].
abstract: Treatment of multiple myeloma (MM), currently an incurable disease, aims to achieve complete remission. Immunomodulatory drugs (IMiDs), represented by thalidomide, are one class of very effective drugs. However, the mechanism of IMiDs action is not yet completely understood. Recent research suggests that cereblon (CRBN) plays an important role in mediating anti-tumor effects of IMiDs; therefore, our review focuses on this protein. CRBN is a substrate receptor of Cul4- E3 ubiquitin ligase complex, and thus recognizes proteins destined for degradation. Bind-ing of CRBN and IMiDs inhibits function of the entire ubiquitin proteasome complex which partly explains their anti-tumor effects. In addition, a correlation between CRBN gene expression and effectiveness of treatment in MM patients treated with IMiDs was confirmed. These findings suggest that CRBN expression could possibly serve as a bio-marker to predict response to IMiD in MM patients.
authors.forename: M
authors.initials: M
authors.lastname: Staňková
authors.forename: L
authors.initials: L
authors.lastname: Bešše
authors.forename: L
authors.initials: L
authors.lastname: Sedlaříková
authors.forename: D
authors.initials: D
authors.lastname: Vrábel
authors.forename: R
authors.initials: R
authors.lastname: Hájek
authors.forename: S
authors.initials: S
authors.lastname: Sevčíková
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor / Q000378:metabolism; D044842:Cullin Proteins / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000627:therapeutic use*; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*; D013792:Thalidomide / Q000627:therapeutic use; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D014408:Biomarkers, Tumor; C502543:CRBN protein, human; C114234:CUL4A protein, human; D044842:Cullin Proteins; D007166:Immunosuppressive Agents; D013792:Thalidomide; D044767:Ubiquitin-Protein Ligases; D010447:Peptide Hydrolases