title: MicroRNAs: promising chemoresistance biomarkers in gastric cancer with diagnostic and therapeutic potential.
abstract: Gastric cancer (GC) is the fourth most common cancer worldwide and ranks second in global cancer mortality statistics. Perioperative chemotherapy plays an important role in the management and treatment of advanced stage disease. However, response to chemotherapy varies widely, with some patients presenting no or only minor response to treatment. Hence, chemotherapy resistance is a major clinical problem that impacts on outcome. Unfortunately, to date there are no reliable biomarkers available that predict response to chemotherapy before the start of the treatment, or that allow modification of chemotherapy resistance. MicroRNAs (miRNAs) could provide an answer to this problem. miRNAs are involved in the initiation and progression of a variety of cancer types, and there is evidence that miRNAs impact on resistance towards chemotherapeutic drugs as well. This current review aims to provide an overview about the potential clinical applicability of miRNAs as biomarkers for chemoresistance in GC. The authors focus in this context on the potential of miRNAs to predict sensitivity towards different chemotherapeutics, and on the potential of miRNAs to modulate sensitivity and resistance towards chemotherapy in GC.
authors.affiliation: Christiane Matuszcak, Richard Hummel, Kirsten Lindner, Department of General and Visceral Surgery, Muenster University Hospital, 48149 Muenster, Germany.
authors.forename: Christiane
authors.initials: C
authors.lastname: Matuszcak
authors.affiliation: Christiane Matuszcak, Richard Hummel, Kirsten Lindner, Department of General and Visceral Surgery, Muenster University Hospital, 48149 Muenster, Germany.
authors.forename: Joerg
authors.initials: J
authors.lastname: Haier
authors.affiliation: Christiane Matuszcak, Richard Hummel, Kirsten Lindner, Department of General and Visceral Surgery, Muenster University Hospital, 48149 Muenster, Germany.
authors.forename: Richard
authors.initials: R
authors.lastname: Hummel
authors.affiliation: Christiane Matuszcak, Richard Hummel, Kirsten Lindner, Department of General and Visceral Surgery, Muenster University Hospital, 48149 Muenster, Germany.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Lindner
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D005820:Genetic Testing; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D018579:Patient Selection; D057285:Precision Medicine; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: Biomarker; Chemoresistance; Diagnostic; Gastric cancer; MicroRNAs; Therapeutic