title: Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases.
abstract: Macroautophagy and chaperone-mediated autophagy (CMA) are two important subtypes of autophagy that play a critical role in cellular quality control under physiological and pathological conditions. Despite the marked differences between these two autophagic pathways, macroautophagy and CMA are intimately connected with each other during the autophagy-lysosomal degradation process, in particular, in the setting of neurological illness. Macroautophagy serves as a backup mechanism to removal of malfunctioning proteins (i.e., aberrant α-synuclein) from the cytoplasm when CMA is compromised, and vice versa. The molecular mechanisms underlying the conversation between macroautophagy and CMA are being clarified. Herein, we survey current overviews concentrating on the complex interactions between macroautophagy and CMA, and present therapeutic potentials through utilization and manipulation of macroautophagy-CMA crosstalk in the treatment of neurological diseases.
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Haijian
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Chen
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Al-Baadani
authors.initials: AB
authors.lastname: Ammar
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Neurological Surgery, Weill Cornell Medical College, New York, USA.
authors.forename: Kum
authors.initials: K
authors.lastname: Pan
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jianmin
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. hy0904@live.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hong
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D016384:Consensus Sequence; D003600:Cytosol / Q000378:metabolism; D050883:HSC70 Heat-Shock Proteins / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology / Q000648:ultrastructure; D008247:Lysosomes / Q000502:physiology / Q000648:ultrastructure; D008561:Membrane Fusion; D058990:Molecular Targeted Therapy; D019636:Neurodegenerative Diseases / Q000628:therapy*; D010588:Phagosomes / Q000502:physiology; D066329:Protein Aggregates; D021381:Protein Transport; D059748:Proteolysis; D014617:Vacuoles / Q000502:physiology; D033921:Vesicular Transport Proteins / Q000502:physiology
chemical_list: D050883:HSC70 Heat-Shock Proteins; D066329:Protein Aggregates; D033921:Vesicular Transport Proteins
keywords: Cell biology; Chaperone-mediated autophagy; Interplay; Macroautophagy; Neurological disease