title: Race and ethnicity influences collection of granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells from unrelated donors, a Center for International Blood and Marrow Transplant Research analysis.
abstract: Little information exists on the effect of race and ethnicity on collection of peripheral blood stem cells (PBSC) for allogeneic transplantation. We studied 10,776 donors from the National Marrow Donor Program who underwent PBSC collection from 2006 to 2012. Self-reported donor race/ethnic information included Caucasian, Hispanic, Black/African American (AA), Asian/Pacific Islander (API), and Native American (NA). All donors were mobilized with subcutaneous filgrastim at an approximate dose of 10 μg/kg/day for 5 days. Overall, AA donors had the highest median yields of mononuclear cells per liter and CD34(+) cells per liter of blood processed (3.1 × 10(9) and 44 × 10(6), respectively), whereas Caucasians had the lowest median yields at 2.8 × 10(9) and 33.7 × 10(6), respectively. Multivariate analysis of CD34(+) per liter mobilization yields using Caucasians as the comparator and controlling for age, gender, body mass index, and year of apheresis revealed increased yields in overweight and obese AA and API donors. In Hispanic donors, only male obese donors had higher CD34(+) per liter mobilization yields compared with Caucasian donors. No differences in CD34(+) per liter yields were seen between Caucasian and NA donors. Characterization of these differences may allow optimization of mobilization regimens to allow enhancement of mobilization yields without compromising donor safety.
authors.affiliation: University of Florida Shands Cancer Center, Gainesville, Florida. Electronic address: hsujw@medicine.ufl.edu.
authors.forename: Jack W
authors.initials: JW
authors.lastname: Hsu
authors.affiliation: University of Florida Shands Cancer Center, Gainesville, Florida.
authors.forename: John R
authors.initials: JR
authors.lastname: Wingard
authors.affiliation: Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Logan
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
authors.forename: Pintip
authors.initials: P
authors.lastname: Chitphakdithai
authors.affiliation: Banner MD Anderson Cancer Center, Gilbert, Arizona.
authors.forename: Gorgun
authors.initials: G
authors.lastname: Akpek
authors.affiliation: University of Texas M.D. Anderson Cancer Center, Houston, Texas.
authors.forename: Paolo
authors.initials: P
authors.lastname: Anderlini
authors.affiliation: University of Chicago Hospitals, Chicago, Illinois.
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Artz
authors.affiliation: Ottawa Hospital Blood and Marrow Transplant Program, Ottawa, Ontario, Canada.
authors.forename: Chris
authors.initials: C
authors.lastname: Bredeson
authors.affiliation: University of Michigan, Ann Arbor, Michigan.
authors.forename: Steven
authors.initials: S
authors.lastname: Goldstein
authors.affiliation: All Children's Hospital, St. Petersburg, Florida.
authors.forename: Gregory
authors.initials: G
authors.lastname: Hale
authors.affiliation: University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
authors.forename: Peiman
authors.initials: P
authors.lastname: Hematti
authors.affiliation: Nationwide Children's Hospital, Columbus, Ohio.
authors.forename: Sarita
authors.initials: S
authors.lastname: Joshi
authors.affiliation: Baylor College of Medicine Center for Cell and Gene Therapy, Houston, Texas.
authors.forename: Rammurti T
authors.initials: RT
authors.lastname: Kamble
authors.affiliation: University Hospitals Case Medical Center, Seidman Cancer Center, Cleveland, Ohio.
authors.forename: Hillard M
authors.initials: HM
authors.lastname: Lazarus
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington.
authors.forename: Paul V
authors.initials: PV
authors.lastname: O'Donnell
authors.affiliation: University of Utah School of Medicine, Primary Children's Hospital, Salt Lake City, Utah.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pulsipher
authors.affiliation: Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
authors.affiliation: Mayo Clinic Rochester, Rochester, Minnesota.
authors.forename: Raquel M
authors.initials: RM
authors.lastname: Schears
authors.affiliation: Anthony Nolan Research Institute, London, United Kingdom.
authors.forename: Bronwen E
authors.initials: BE
authors.lastname: Shaw
authors.affiliation: Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota; National Marrow Donor Program, Minneapolis, Minnesota.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Confer
mesh_terms: D000293:Adolescent; D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D015992:Body Mass Index; D002452:Cell Count; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D007279:Injections, Subcutaneous; D007391:International Cooperation; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D044469:Racial Groups; D011994:Recombinant Proteins / Q000008:administration & dosage; D061349:Unrelated Donors
chemical_list: D018952:Antigens, CD34; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim
keywords: Ethnicity; Granulocyte colony–stimulating factor (G-CSF); Mobilization; Race