title: [Effects of interrupted abdominal aorta compression on cardiopulmonary cerebral resuscitation after cardiac arrest in rabbit].
abstract: OBJECTIVE
  To explore the effect of the interrupted abdominal aorta compression after cardiopulmonary resuscitation (IAAC-CPR) on cardiopulmonary cerebral resuscitation in a rabbit model of cardiac arrest (CA).
  
  
  METHODS
  According to the random number table, 10 New Zealand rabbits of both genders were equally divided into the chest compression-cardiopulmonary resuscitation (CC-CPR) group or IAAC-CPR group, with 5 rabbits in each group. CA model was reproduced by injection of iced-potassium chloride into the jugular vein and obstruction of trachea to produce asphyxia. CA was maintained for 3 minutes before cardiopulmonary resuscitation(CPR). CC-CPR was performed with assisted ventilation + chest compression, while IAAC-CPR was performed by the way of assisted ventilation + chest compressions + compressions on abdominal aorta. The hemodynamics and cerebral cortex blood flow were observed during resuscitation. Time of return of spontaneous circulation (ROSC), 24-hour survival rates, and scores of neurological function, and situation of abdominal organs were recorded.
  
  
  RESULTS
  At 30, 60, 90 and 120 seconds after CPR, the cerebral blood flow (CBF, PU value) and mean arterial pressure (MAP, mmHg, 1 mmHg=0.133 kPa) of IAAC-CPR group were significantly higher than those of CC-CPR group (CBF 30 seconds: 16.1 ± 6.0 vs. 7.8 ± 2.2, 60 seconds: 91.6 ± 11.8 vs. 57.3 ± 23.2, 90 seconds: 259.9 ± 74.9 vs. 163.6 ± 50.3, 120 seconds: 301.5 ± 60.5 vs. 208.4 ± 23.8; MAP 30 seconds: 46.4 ± 9.4 vs. 31.4 ± 8.7, 60 seconds: 55.8 ± 13.8 vs. 34.0 ± 11.5, 90 seconds: 61.2 ± 11.5 vs. 38.2 ± 10.1, 120 seconds: 63.6 ± 11.8 vs. 40.2 ± 10.2, all P<0.05). Compared with CC-CPR group, in IAAC - CPR group, the time necessary for ROSC was obviously shortened (seconds: 182.0 ± 59.0 vs. 312.6 ± 86.6, t=2.787, P=0.024), 24-hour nerve function score was significantly lowered (2.4 ± 1.7 vs. 4.6 ± 0.6, t = 2.974, P = 0.023). The successful recovery rate (80.0% vs. 60.0%, χ² = 0.000, P=1.000) and 24-hour survival rate (80.0% vs. 40.0%, χ² = 0.417, P=0.519) were significantly increased, but without statistical significance. No liver damage was found at 24 hours after ROSC.
  
  
  CONCLUSIONS
  In the early recovery of CA in rabbit, IAAC-CPR can result in better cerebral blood flow perfusion as compared with CC-CPR, and it significantly reduced damage to the nervous system function without producing abdominal organ damage.
authors.affiliation: Emergency Medical Center, General Hospital of Chinese Armed Police Forces, Beijing 100039, China, Corresponding author: Wang Lixiang, Email: wjjjwlx@163.com.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Dou
authors.forename: Lixiang
authors.initials: L
authors.lastname: Wang
authors.forename: Huiliang
authors.initials: H
authors.lastname: Liu
authors.forename: Pengchuan
authors.initials: P
authors.lastname: Zhang
authors.forename: Chengcheng
authors.initials: C
authors.lastname: Guo
authors.forename: Yahua
authors.initials: Y
authors.lastname: Liu
authors.forename: Lizhi
authors.initials: L
authors.lastname: Ma
authors.forename: Kun
authors.initials: K
authors.lastname: Sun
authors.forename: Wenjun
authors.initials: W
authors.lastname: Ma
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Guo
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000502:physiology*; D062186:Arterial Pressure; D001237:Asphyxia; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000628:therapy*; D006439:Hemodynamics; D011312:Pressure; D011817:Rabbits; D012121:Respiration, Artificial; D015996:Survival Rate; D016896:Treatment Outcome