title: A microwave radiosynthesis of the 4-[18F]-fluorobenzyltriphenylphosphonium ion.
abstract: The 4-[(18)F]-fluorobenzyltriphenylphosphonium cation was synthesized by a series of microwave reactions from no carrier added [(18)F]-fluoride. The microwave procedure reduced the quantity of reagents used and synthesis time when compared with the original synthesis. In addition, problematic solid phase extraction, sodium borohydride reduction by column and inconsistent yields with excessive precipitate formation during the bromination step were eliminated. The 4-[(18)F]-fluorobenzyltriphenylphosphonium cation was produced radiochemically pure in 8.3% yield with a specific radioactivity of 534.5 ± 371.4 GBq/µmole at end of synthesis.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Nelson B1-152, Baltimore, Maryland, 21287, USA.
authors.forename: Hayden T
authors.initials: HT
authors.lastname: Ravert
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Holt
authors.forename: Robert F
authors.initials: RF
authors.lastname: Dannals
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation / Q000379:methods*; D008872:Microwaves; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: C513681:18F-fluorobenzyl triphenyl phosphonium; D009943:Organophosphorus Compounds; D019275:Radiopharmaceuticals
keywords: fluorine-18; microwave; phosphonium; positron emission tomography