title: Group A streptococcal bacteremia without a source is associated with less severe disease in children.
abstract: We analyzed characteristics of 86 Group A streptococcal bacteremia cases at Boston Children's Hospital from 1992 to 2012. Twenty-three percent of children had severe disease, using intensive care unit admission (18), disability (7) or death (2) as indicators. Children with bacteremia without a source (30% of cases) were less likely to have severe disease than children with focal infections in adjusted models.
authors.affiliation: From the *Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, Massachusetts; †Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts; ‡Clinical Research Center, Boston Children's Hospital, Boston, Massachusetts; §Department of Population Medicine, Harvard Medical School & Harvard Pilgrim Health Care Institute, Boston, Massachusetts; ¶Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; and ‖Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Gauguet
authors.forename: Asim A
authors.initials: AA
authors.lastname: Ahmed
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Pfoh
authors.forename: Kathryn K
authors.initials: KK
authors.lastname: Ahnger-Pier
authors.forename: Marvin B
authors.initials: MB
authors.lastname: Harper
authors.forename: Al
authors.initials: A
authors.lastname: Ozonoff
authors.forename: Michael R
authors.initials: MR
authors.lastname: Wessels
authors.forename: Grace M
authors.initials: GM
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D016470:Bacteremia / Q000453:epidemiology / Q000473:pathology*; D001900:Boston / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000453:epidemiology / Q000473:pathology*; D016019:Survival Analysis