title: Indocyanine green plasma disappearance rate as dynamic liver function test in critically ill patients.
abstract: BACKGROUND
  Indocyanine green (ICG) is a water-soluble fluorescent dye that is bound to plasma protein when administered intravenously. Removal of ICG from the blood depends on hepatic blood flow, function of the parenchymal cells and biliary excretion. ICG elimination is described as a useful dynamic liver function test.
  
  
  METHODS
  In this review, we looked at the most recent literature to clarify why ICG is useful in critically ill patients, the validity of the ICG plasma disappearance rate (ICG-PDR) measured transcutaneously and whether ICG-PDR has any prognostic value.
  
  
  CONCLUSIONS
  In conclusion, measuring ICG-PDR is a valuable method for dynamic assessment of liver function, and is found to be a valuable prognostic tool in predicting survival for septic patients, patients presenting with acute liver failure and critically ill patients.
authors.affiliation: Department of Anesthesia and Intensive Care, Copenhagen University Hospital Roskilde, Roskilde, Region Zealand, Denmark.
authors.forename: B M
authors.initials: BM
authors.lastname: Halle
authors.forename: T D
authors.initials: TD
authors.lastname: Poulsen
authors.forename: H P
authors.initials: HP
authors.lastname: Pedersen
mesh_terms: D004396:Coloring Agents / Q000493:pharmacokinetics; D016638:Critical Illness; D006801:Humans; D007208:Indocyanine Green / Q000493:pharmacokinetics*; D008111:Liver Function Tests / Q000379:methods*; D011379:Prognosis; D015203:Reproducibility of Results
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green