title: Synthesis of L-Lys-Aminoxy-Goralatide.
abstract: Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, PO Box: 117200, Gainesville, FL, 32611-7200, USA.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Li
authors.forename: Iryna
authors.initials: I
authors.lastname: Lebedyeva
authors.forename: Deqian
authors.initials: D
authors.lastname: Zhao
authors.forename: Lauren
authors.initials: L
authors.lastname: Myers
authors.forename: Girinath G
authors.initials: GG
authors.lastname: Pillai
authors.forename: Charles Dennis
authors.initials: CD
authors.lastname: Hall
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000599391:L-lys-aminoxy-goralatide; D009842:Oligopeptides; D010455:Peptides
keywords: Goralatide; acylation; coupling; peptides; peptidomimetics