title: Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases.
abstract: Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administered cocaine and transient increases in MMP-9 during cue-induced cocaine relapse. Cue-induced heroin and nicotine relapse increased MMP activity, and increased MMP activity was required for both cocaine relapse and relapse-associated synaptic plasticity.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Alexander C W
authors.initials: AC
authors.lastname: Smith
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Yonatan M
authors.identifier: 0000000337324933
authors.initials: YM
authors.lastname: Kupchik
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Scofield
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Cassandra D
authors.initials: CD
authors.lastname: Gipson
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Armina
authors.initials: A
authors.lastname: Wiggins
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Thomas
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kalivas
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D003042:Cocaine / Q000008:administration & dosage*; D019970:Cocaine-Related Disorders / Q000201:enzymology* / Q000473:pathology; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis*; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis*; D009473:Neuronal Plasticity / Q000502:physiology*; D009924:Organ Culture Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D012646:Self Administration
chemical_list: D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D003042:Cocaine