title: Ovarian aging and premature ovarian failure.
abstract: Physiological reproductive aging occurs as a result of a decrease in the number and quality of oocytes in ovarian cortex follicles. Although the reason for the decrease in the quality of the pool and follicular oocytes is not fully understood, endocrine, paracrine, genetic, and metabolic factors are thought to be effective. Nowadays, in order to understand the mechanisms of ovarian aging, genomic research has gained importance. The effect of co-factors, such as telomerase and ceramide, in the ovarian aging process is only getting ascertained with new research studies. The most important tests in the assessment of ovarian aging are antral follicle count and anti-Mullerian hormone.
authors.affiliation: Department of Obstetrics and Gynecology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Yavuz Emre
authors.initials: YE
authors.lastname: Sükür
authors.affiliation: Department of Obstetrics and Gynecology, Gazimagusa State Hospital, Gazimagusa, Turkish Republic of Northern Cyprus.
authors.forename: Içten Balık
authors.initials: IB
authors.lastname: Kıvançlı
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, Ankara, Turkey.
authors.forename: Batuhan
authors.initials: B
authors.lastname: Ozmen
keywords: Ovarian aging; premature ovarian failure; reproduction