title: Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause.
abstract: Nothobranchius is a genus of annual fish broadly distributed in South-Eastern Africa and found into temporary ponds generated during the rain seasons and their lifespan is limited by the duration of their habitats. Here we compared two Nothobranchius species from radically different environments: N. furzeri and N. korthausae. We found a large difference in life expectancy (29- against 71-weeks of median life span, 40- against 80-weeks of maximum lifespan, respectively), which correlates with a diverse timing in the onset of several age dependent processes: our data show that N. korthause longer lifespan is associated to retarded onset of age-dependent liver-neoplasia and slower down-regulation of collagen 1 alpha 2 (COL1A2) expression in the skin. On the other hand, the expression of cyclin B1 (CCNB1) in the brain was strongly age-regulated, but with similar profiles in N. furzeri and N. korthausae. In conclusion, our data suggest that the different ageing rate of two species of the same genus could be used as novel tool to investigate and better understand the genetic bases of some general mechanism leading to the complex ageing process, providing a strategy to unravel some of the genetic mechanisms regulating longevity and age-associate pathologies including neoplasias.
authors.affiliation: Biology of Aging, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Baumgart
authors.forename: Emiliano
authors.initials: E
authors.lastname: Di Cicco
authors.forename: Giacomo
authors.initials: G
authors.lastname: Rossi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cellerino
authors.forename: Eva Terzibasi
authors.initials: ET
authors.lastname: Tozzini
mesh_terms: D000353:Africa, Southern; D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D056744:Cyclin B1 / Q000235:genetics / Q000378:metabolism; D003532:Cyprinodontiformes / Q000145:classification / Q000235:genetics* / Q000502:physiology*; D005260:Female; D015870:Gene Expression / Q000235:genetics / Q000502:physiology*; D015994:Incidence; D008113:Liver Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D008136:Longevity / Q000235:genetics* / Q000502:physiology*; D008297:Male; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012621:Seasons; D012867:Skin / Q000378:metabolism; D013045:Species Specificity
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D056744:Cyclin B1; D012333:RNA, Messenger