title: Histone core modifications regulating nucleosome structure and dynamics.
abstract: Post-translational modifications of histones regulate all DNA-templated processes, including replication, transcription and repair. These modifications function as platforms for the recruitment of specific effector proteins, such as transcriptional regulators or chromatin remodellers. Recent data suggest that histone modifications also have a direct effect on nucleosomal architecture. Acetylation, methylation, phosphorylation and citrullination of the histone core may influence chromatin structure by affecting histone-histone and histone-DNA interactions, as well as the binding of histones to chaperones.
authors.affiliation: Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK; and the Max Planck Research Group 'Chromatin and Ageing', Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Tessarz
authors.affiliation: Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QN, UK.
authors.forename: Tony
authors.initials: T
authors.lastname: Kouzarides
mesh_terms: D000107:Acetylation; D002956:Citrulline / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D004261:DNA Replication; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008745:Methylation; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
chemical_list: D006657:Histones; D018832:Molecular Chaperones; D009707:Nucleosomes; D002956:Citrulline; D004247:DNA