title: Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis.
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.|Université Paul Sabatier, Toulouse III, Toulouse, France.|Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.
authors.forename: Stanislas
authors.initials: S
authors.lastname: Faguer
authors.affiliation: Université Paul Sabatier, Toulouse III, Toulouse, France.|Laboratoire d'Immunologie, CHU Rangueil, Toulouse, France.
authors.forename: François
authors.initials: F
authors.lastname: Vergez
authors.affiliation: Université Paul Sabatier, Toulouse III, Toulouse, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Peres
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.
authors.forename: Inès
authors.initials: I
authors.lastname: Ferrandiz
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Casemayou
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.|Université Paul Sabatier, Toulouse III, Toulouse, France.|Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Institut of Cardiovascular and Metabolic Disease, Toulouse, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Belliere
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Cointault
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Lavayssiere
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.
authors.forename: Marie-Béatrice
authors.initials: MB
authors.lastname: Nogier
authors.affiliation: Service de Pneumologie, CHU Larrey, Toulouse, France.
authors.forename: Grégoire
authors.initials: G
authors.lastname: Prevot
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Huart
authors.affiliation: Université Paul Sabatier, Toulouse III, Toulouse, France.|Service d'Hématologie, CHU Purpan, Toulouse, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Recher
authors.affiliation: Département de Néphrologie et Transplantation d'organes, CHU Rangueil, Toulouse, France.|Université Paul Sabatier, Toulouse III, Toulouse, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002455:Cell Division; D003520:Cyclophosphamide / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood*; D004351:Drug Resistance; D053804:Granzymes / Q000032:analysis; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008213:Lymphocyte Activation; D018655:Lymphocyte Count; D051359:Lymphohistiocytosis, Hemophagocytic / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D017582:Renal Replacement Therapy; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D016879:Salvage Therapy; D016176:T-Lymphocyte Subsets / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000201:enzymology / Q000276:immunology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D016207:Cytokines; D003520:Cyclophosphamide; D053804:Granzymes; C502936:tocilizumab; D008775:Methylprednisolone