title: Analysis and Modeling of Anatomical Changes of the Anterior Segment of the Eye After Cataract Surgery with Consideration of Different Phenotypes of Eye Structure.
abstract: OBJECTIVE
  To study the relationship between phacoemulsification-related changes and the baseline parameters of the anterior chamber.
  
  
  METHODS
  Military Institute of Medicine, Warsaw, Medical University of Lublin, Medical University of Bialystok.
  
  
  METHODS
  The study included 228 patients. Anterior chamber depth (ACD), trabecular-iris angle (TIA), central lens thickness (CLT) and axial length of the eye (AXL) were determined prior to and 6 months after surgery. These measurements were used to calculate the ACD(index) describing the degree of postoperative changes in the anterior chamber. K-means clustering, multiple regression and neural networks were used for the analysis.
  
  
  RESULTS
  Cataract surgery was reflected by changes in ACD and TIA. The character of changes was described by ACD(index) (p < 0.05). Mean ACD0 was 2.51 ± 0.45 mm and increased to 3.84 ± 0.35 mm (p < 0.05), whereas mean TIA0 was 22.84 ± 7.43° and increased to 30.97 ± 7.99° (p < 0.05). ΔACD and ΔTIA were determined on the basis of baseline parameters defined by ACD(index), characterizing the structural type of the eye. The variability of ACD(index) explained 42.65% of variance in ΔACD and ΔTIA. The quality of network for validation and test samples was from 0.72 to 0.83.
  
  
  CONCLUSIONS
  Cataract surgery-related changes in ACD and TIA are determined by the type of the eye. Although the linear model of the relationship between baseline parameters of the eye and their postoperative changes is correct, it does not explain the degree of the latter phenomenon. Preoperative consideration of other parameters characterizing anatomical relationships of the eye would enable the prediction of phacoemulsification-related changes in the anterior segment.
authors.affiliation: a Department of Ophthalmology , Military Institute of Medicine in Warsaw , Warsaw , Poland .
authors.forename: Marek
authors.initials: M
authors.lastname: Rękas
authors.affiliation: b Department of Glaucoma Diagnostic and Microsurgery , Medical University of Lublin , Lublin , Poland and.
authors.forename: Kamilla
authors.initials: K
authors.lastname: Barchan-Kucia
authors.affiliation: c Department of Ophthalmology , Medical University of Bialystok , Bialystok , Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Konopińska
authors.affiliation: c Department of Ophthalmology , Medical University of Bialystok , Bialystok , Poland.
authors.forename: Zofia
authors.initials: Z
authors.lastname: Mariak
authors.affiliation: b Department of Glaucoma Diagnostic and Microsurgery , Medical University of Lublin , Lublin , Poland and.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Żarnowski
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000867:Anterior Chamber / Q000473:pathology; D000869:Anterior Eye Segment / Q000033:anatomy & histology / Q000473:pathology*; D058452:Axial Length, Eye / Q000473:pathology; D005260:Female; D006801:Humans; D007498:Iris / Q000473:pathology; D019654:Lens Implantation, Intraocular; D008297:Male; D033401:Microscopy, Acoustic; D016571:Neural Networks, Computer; D018918:Phacoemulsification; D010641:Phenotype; D011184:Postoperative Period; D014129:Trabecular Meshwork / Q000473:pathology
keywords: Anterior chamber depth; modeling of the anterior chamber changes; phacoemulsification-related changes; trabecular-iris angle; ultrabiomicroscopic evaluation