title: Ratio of prostate specific antigen to the outer gland volume of prostrate as a predictor for prostate cancer.
abstract: OBJECTIVE
  As a definite diagnosis of prostate cancer, puncture biopsy of the prostate is invasive method. The aim of this study was to evaluate the value of OPSAD (the ratio of PSA to the outer gland volume of prostate) as a non-invasive screening and diagnosis method for prostate cancer in a select population.
  
  
  METHODS
  The diagnosis data of 490 subjects undergoing ultrasound-guided biopsy of the prostate were retrospectively analyzed. This included 133 patients with prostate cancer, and 357 patients with benign prostate hyperplasia (BPH).
  
  
  RESULTS
  The OPSAD was significantly greater in patients with prostate cancer (1.87 ± 1.26 ng/ml(2)) than those with BPH (0.44 ± 0.21 ng/ml(2)) (P < 0.05). Receiver operating characteristic (ROC) curve analysis revealed that the performance of OPSAD as a diagnostic tool is superior to PSA and PSAD for the diagnosis of prostate cancer. In the different groups divided according to the Gleason score of prostate cancer, OPSAD is elevated with the rise of the Gleason score.
  
  
  CONCLUSIONS
  OPSAD may be used as a new indicator for the diagnosis and prognosis of prostate cancer, and it can reduce the use of unnecessary puncture biopsy of the prostate.
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Hai-Min
authors.initials: HM
authors.lastname: Zhang
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yan
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Gu
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Hu
authors.affiliation: Department of Urology, Shanghai Tenth People's Hospital, Tongji University Shanghai, China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods; D007118:Immunoassay; D007610:Kallikreins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009929:Organ Size; D011237:Predictive Value of Tests; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D012372:ROC Curve; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Prostate cancer; benign prostate hyperplasia; diagnosis; outer gland of the prostate; prostate specific antigen; prostate specific antigen density