title: 2D Computational Fluid Dynamic Modeling of Human Ventricle System Based on Fluid-Solid Interaction and Pulsatile Flow.
abstract: Many diseases are related to cerebrospinal fluid (CSF) hydrodynamics. Therefore, understanding the hydrodynamics of CSF flow and intracranial pressure is helpful for obtaining deeper knowledge of pathological processes and providing better treatments. Furthermore, engineering a reliable computational method is promising approach for fabricating in vitro models which is essential for inventing generic medicines. A Fluid-Solid Interaction (FSI)model was constructed to simulate CSF flow. An important problem in modeling the CSF flow is the diastolic back flow. In this article, using both rigid and flexible conditions for ventricular system allowed us to evaluate the effect of surrounding brain tissue. Our model assumed an elastic wall for the ventricles and a pulsatile CSF input as its boundary conditions. A comparison of the results and the experimental data was done. The flexible model gave better results because it could reproduce the diastolic back flow mentioned in clinical research studies. The previous rigid models have ignored the brain parenchyma interaction with CSF and so had not reported the back flow during the diastolic time. In this computational fluid dynamic (CFD) analysis, the CSF pressure and flow velocity in different areas were concordant with the experimental data.
authors.affiliation: Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran.
authors.forename: Nafiseh
authors.initials: N
authors.lastname: Masoumi
authors.affiliation: Biomechanics Group Faculty, Mechanical Engineering Department, Iranian University of Science and Technology, Tehran, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Framanzad
authors.affiliation: Department of Chemical Engineering, North Eastern University, Boston, MA,USA.
authors.forename: Behnam
authors.initials: B
authors.lastname: Zamanian
authors.affiliation: Neurosurgery Department, Shohada-e-Tajrish Hospital, ShahidBeheshti University of Medical Sciences, Tehran, Iran.
authors.forename: A S
authors.initials: AS
authors.lastname: Seddighi
authors.affiliation: Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: M H
authors.initials: MH
authors.lastname: Moosavi
authors.affiliation: Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Najarian
authors.affiliation: Faculty of Chemical & Petroleum Engineering Department, Sharif University of Technology, Tehran, Iran.
authors.forename: Dariush
authors.initials: D
authors.lastname: Bastani
keywords: Cerebrospinal Fluid; Computational Fluid Dynamics (CFD); FSI modeling; Hydrodynamics; Pulsatile