title: Unique expression pattern of viral proteins in human herpesvirus 8-positive plasmablastic lymphoma: a case report.
abstract: BACKGROUND
  Human herpesvirus 8 (HHV8)-positive plasmablastic lymphoma is a disease which correlates with acquired immunodeficiency syndrome (AIDS). Little is known about the pathogenesis of the disease due to its rarity. We report an autopsy case about AIDS related HHV-8-positive plasmablastic lymphoma and presents an examination about HHV8 related proteins for the disease by using immunohistochemical techniques.
  
  
  METHODS
  Two kinds of tumors complicated the male AIDS patient: one was HHV-8-positive plasmablastic lymphoma and the other was Kaposi's sarcoma (KS). Immunohistochemically, the lymphoma cells were positive for HHV8-associated lytic early proteins as well as HHV8 latency-associated nuclear antigen 1 (LANA-1), and, on the other hand, the lymphoma cells were negative for lytic immediately early proteins. KS was positive for only LANA-1.
  
  
  CONCLUSIONS
  These findings indicate that the lymphoma cells acquired an ability to proliferate without de novo HHV8 replication. Moreover, the onset mechanisms of HHV-8-positive plasmablastic lymphoma may be different from those of KS.
authors.affiliation: Department of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Yamada
authors.affiliation: Department of Pathology, National Institute of Infectious Disease Tokyo, Japan.
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
authors.forename: Mihoko
authors.initials: M
authors.lastname: Yotsumoto
authors.affiliation: Department of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Hashimoto
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramatsu
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Shiotsuka
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University Hospital Tokyo, Japan.
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Fukutake
authors.affiliation: Department of Molecular Pathology, Tokyo Medical University Tokyo, Japan.
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kuroda
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D001344:Autopsy; D050976:Basic-Leucine Zipper Transcription Factors / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D005871:Castleman Disease / Q000276:immunology / Q000473:pathology / Q000821:virology*; D049109:Cell Proliferation; D017809:Fatal Outcome; D019288:Herpesvirus 8, Human / Q000276:immunology / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans; D017874:Immediate-Early Proteins / Q000032:analysis; D007150:Immunohistochemistry; D016483:Lymphoma, AIDS-Related / Q000276:immunology / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012097:Repressor Proteins / Q000032:analysis; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology / Q000821:virology*; D015534:Trans-Activators / Q000032:analysis; D014516:Ureteral Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014764:Viral Proteins / Q000032:analysis*; D014779:Virus Replication
chemical_list: D000956:Antigens, Viral; D050976:Basic-Leucine Zipper Transcription Factors; D014408:Biomarkers, Tumor; D017874:Immediate-Early Proteins; C118265:K8 protein, Human herpesvirus 8; D009687:Nuclear Proteins; D012097:Repressor Proteins; C417604:Rta protein, Human herpesvirus 8; D015534:Trans-Activators; D014764:Viral Proteins; C109540:latency-associated nuclear antigen
keywords: HHV-8 latency-associated nuclear antigen 1; HHV-8-associated plasmablastic lymphoma; large B-cell lymphoma arising in HHV8-associated multicentric Castleman’s disease; open reading frame 59; viral interleukin-6