title: Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale.
abstract: Hyperthermia has been conventionally used in conjunction with photon beam irradiation. With a gradual increase in particle therapy facilities worldwide, this paper explores the physical, thermal and radiobiological implications of using a combination of hyperthermia with proton beam therapy. Hyperthermia is known to exhibit radiobiological features similar to those of high linear energy transfer radiation. Protons have many of the physical dose distribution properties of (12)C ion therapy. Thus, the thermo-radiobiological advantages of hyperthermia coupled with the physical dose distribution advantages of proton beams could possibly mimic (12)C ion therapy.
authors.affiliation: Centre for Radiation Oncology, KSA-KSB, Kantonsspital Aarau , Aarau , Switzerland .
authors.forename: Niloy R
authors.initials: NR
authors.lastname: Datta
authors.forename: Emsad
authors.initials: E
authors.lastname: Puric
authors.forename: Ralf
authors.initials: R
authors.lastname: Schneider
authors.forename: Damien C
authors.initials: DC
authors.lastname: Weber
authors.forename: Susanne
authors.initials: S
authors.lastname: Rogers
authors.forename: Stephan
authors.initials: S
authors.lastname: Bodis
mesh_terms: D002244:Carbon / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D061766:Proton Therapy
chemical_list: D002244:Carbon
keywords: Carbon ion therapy; hyperthermia; proton therapy; radiobiology; sarcoma