title: Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study.
abstract: BACKGROUND
  To evaluate factors for predicting the granulosa cell tumor of the ovary (GCTO) pre-operatively.
  
  
  METHODS
  This retrospective designed study was conducted on 34 women with GCTO as the study group and 76 women with benign ovarian cysts as the control group. Data were recorded from the hospital database and included age, body mass index (BMI), parity, serum estradiol (E2) levels, diameter of the mass, ultrasonographic features, serum CA125 level, risk of malignancy index (RMI), duration of menopause, postoperative histopathology result, and the neutrophil/lymphocyte ratio (NLR).
  
  
  RESULTS
  The demographic parameters showed no statistically significant difference between the groups. Preoperative diameter of the mass, CA125, duration of menopause, and neutrophil/lymphocyte ratio were significantly different between the groups. ROC curve analysis demonstrated that diameter of the mass, serum estradiol and Ca125 levels, RMI and NLR may be discriminative factors in predicting GCTO preoperatively.
  
  
  CONCLUSIONS
  In conclusion, we think that a careful preoperative workshop including diameter of the mass, serum estradiol (E2) and Ca125 levels, RMI and NLR may predict GCTO and may prevent incomplete approaches.
authors.affiliation: Obstetrics and Gynecology, Dr Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey E-mail : aytekintokmak@gmail.com.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Yesilyurt
authors.forename: Aytekin
authors.initials: A
authors.lastname: Tokmak
authors.forename: Ali Irfan
authors.initials: AI
authors.lastname: Guzel
authors.forename: Hakki Sencer
authors.initials: HS
authors.lastname: Simsek
authors.forename: Serdar Gokay
authors.initials: SG
authors.lastname: Terzioglu
authors.forename: Salim
authors.initials: S
authors.lastname: Erkaya
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D010048:Ovarian Cysts / Q000378:metabolism / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor