title: Treatment of neuro-ophthalmic sarcoidosis.
abstract: BACKGROUND
  Because of the rarity of neuro-ophthalmic sarcoidosis, there are no therapeutic guidelines based on evidence-based medicine for this disorder.
  
  
  METHODS
  Review of literature combined with personal experience.
  
  
  RESULTS
  Corticosteroids are the preferred initial therapy for neuro-ophthalmic sarcoidosis. If patients cannot tolerate the requisite dose of corticosteroid needed to control their disease, or if corticosteroids fail to adequately control the disease process, the choices of a second agent are based on the consideration of rapidity of clinical response and the safety profile.
  
  
  CONCLUSIONS
  Although methotrexate and mycophenolate mofetil are the medications that are often selected after corticosteroid failure, more rapidly acting agents that have been used are infliximab and intravenous cyclophosphamide.
authors.affiliation: Departments of Ophthalmology & Visual Sciences and Neurology & Neurosciences, Rutgers-New Jersey Medical School, Newark, New Jersey.
authors.forename: Larry P
authors.initials: LP
authors.lastname: Frohman
mesh_terms: D005128:Eye Diseases / Q000150:complications / Q000628:therapy*; D006801:Humans; D009422:Nervous System Diseases / Q000150:complications / Q000628:therapy*; D009462:Neurology; D009885:Ophthalmology; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*