title: Mucoadhesive system formed by liquid crystals for buccal administration of poly(hexamethylene biguanide) hydrochloride.
abstract: Antimicrobial approaches are valuable in controlling the development of buccal diseases, but some antibacterial agents have a short duration of activity. Therefore, the development of prolonged delivery systems would be advantageous. Liquid crystalline systems comprising monoolein (GMO)/water have been considered to be a potential vehicle to deliver drugs to the buccal mucosa because of the phase properties that allow for controlled drug release as well as its mucoadhesive properties. Therefore, the aim of this study was to develop a GMO/water system for the slow release of poly(hexamethylene biguanide) hydrochloride (PHMB) on the buccal mucosa and test the properties of this system with regard to swelling, release profile, antimicrobial activity, and strength of mucoadhesion, with the overall goal of treating buccal infections. The tested systems were capable of modulating drug release, which is controlled by diffusion of the drug throughout the system. Furthermore, PHMB appeared to improve the mucoadhesive properties of the system and may synergistically act with the drug to promote antimicrobial activity against S. mutas and C. albicans, indicating that liquid crystals may be suitable for the administration of PHMB on the buccal mucosa. Therefore, this system could be proposed as a novel system for mucoadhesive drug delivery.
authors.affiliation: School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil. Electronic address: ca_souza@usp.br.
authors.forename: Carla
authors.initials: C
authors.lastname: Souza
authors.affiliation: School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil.
authors.forename: Evandro
authors.initials: E
authors.lastname: Watanabe
authors.affiliation: School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil.
authors.forename: Livia Neves
authors.initials: LN
authors.lastname: Borgheti-Cardoso
authors.affiliation: Institute of Physics, University of São Paulo, São Paulo 05508-090, Brazil.
authors.forename: Márcia Carvalho
authors.initials: MC
authors.lastname: De Abreu Fantini
authors.affiliation: School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo 14040-903, Brazil.
authors.forename: Marilisa Guimarães
authors.initials: MG
authors.lastname: Lara
mesh_terms: D000269:Adhesives / Q000008:administration & dosage* / Q000737:chemistry*; D000278:Administration, Buccal; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems / Q000379:methods; D005989:Glycerides / Q000008:administration & dosage; D006146:Guanidines / Q000008:administration & dosage* / Q000737:chemistry*; D050866:Liquid Crystals / Q000737:chemistry*; D009061:Mouth Mucosa / Q000378:metabolism*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D000269:Adhesives; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005989:Glycerides; D006146:Guanidines; D011108:Polymers; C107145:poly(hexamethylenebiguanidinium); C005953:monoolein
keywords: PHMB; antimicrobial activity; biomaterials; controlled release; lipids; liquid crystal; monoolein; mucoadhesion; mucosal drug delivery; surfactants