title: Adenovirus hepatitis presenting as tumoral lesions in an immunocompromised patient.
abstract: A 59-year-old man with T-cell prolymphocytic leukemia on alemtuzumab presented with neutropenic fever, intermittent nausea, and multiple ill-defined low attenuation foci in the liver on abdominal computed tomography scan which were suspicious for metastatic disease. Histological examination revealed the diagnosis of adenovirus hepatitis. Patient responded well to cidofovir. Adenovirus hepatitis is a rare but important entity to be considered by the clinicians, radiologists, and pathologists. Timely diagnosis and appropriate management are essential to improve the prognosis of adenovirus hepatitis in immunocompromised patients.
authors.affiliation: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States.
authors.forename: Juan
authors.initials: J
authors.lastname: Putra
authors.affiliation: Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States.
authors.forename: Arief A
authors.initials: AA
authors.lastname: Suriawinata
mesh_terms: D000258:Adenovirus Infections, Human / Q000139:chemically induced* / Q000000981:diagnostic imaging; D000074323:Alemtuzumab; D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D064146:Chemotherapy-Induced Febrile Neutropenia / Q000209:etiology*; D006525:Hepatitis, Viral, Human / Q000139:chemically induced* / Q000000981:diagnostic imaging; D006801:Humans; D016867:Immunocompromised Host; D015461:Leukemia, Prolymphocytic, T-Cell / Q000188:drug therapy*; D008099:Liver / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000074323:Alemtuzumab