title: Gut microbiota: a source of novel tools to reduce the risk of human disease?
abstract: Modern civilization is faced with a progressive increase in immune-mediated or inflammatory health problems such as allergic disease, autoimmune disorders, and obesity. An extended version of the hygiene hypothesis has been introduced to emphasize the intimate interrelationship among diet, the immune system, microbiome, and origins of human disease: the modern infant, particularly when delivered by cesarean section and without the recommended exclusive breastfeeding, may lack sufficient stimulation of the mucosal immune system to generate a tolerogenic immune milieu and instead be prone to develop chronic inflammatory conditions. These deviations may take the form of allergic or autoimmune disease, or predispose the child to higher weight gain and obesity. Moreover, evidence supports the role of first microbial contacts in promoting and maintaining a balanced immune response in early life and recent findings suggest that microbial contact begins prior to birth and is shaped by the maternal microbiota. Maternal microbiota may prove to be a safe and effective target for interventions decreasing the risk of allergic and noncommunicable diseases in future generations. These results support the hypothesis that targeting early interaction with microbes might offer an applicable strategy to prevent disease.
authors.affiliation: 1] Institute of Agrochemistry and Food Technology (IATA-CSIC), Spanish National Research Council, Valencia, Spain [2] Functional Foods Forum, University of Turku, Turku, Finland.
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Collado
authors.affiliation: Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Samuli
authors.initials: S
authors.lastname: Rautava
authors.affiliation: Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Erika
authors.initials: E
authors.lastname: Isolauri
authors.affiliation: Functional Foods Forum, University of Turku, Turku, Finland.
authors.forename: Seppo
authors.identifier: 0000000297377642
authors.initials: S
authors.lastname: Salminen
mesh_terms: D000818:Animals; D002648:Child; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D061148:Hygiene Hypothesis; D007154:Immune System Diseases / Q000517:prevention & control*; D007231:Infant, Newborn; D007249:Inflammation / Q000517:prevention & control*; D064307:Microbiota; D008895:Milk, Human / Q000382:microbiology*; D056692:Prebiotics / Q000032:analysis; D019936:Probiotics / Q000627:therapeutic use
chemical_list: D056692:Prebiotics