title: The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics.
abstract: BACKGROUND
  Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects.
  
  
  METHODS
  For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others.
  
  
  RESULTS
  Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups.
  
  
  CONCLUSIONS
  These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.
authors.affiliation: The Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren), Ferdowsi University of Mashhad, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Moghimi
authors.affiliation: Biotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
authors.forename: Samaneh
authors.initials: S
authors.lastname: Mollazadeh
authors.affiliation: Cell and Molecular Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran.
authors.forename: Fatemeh Behnam
authors.initials: FB
authors.lastname: Rassouli
authors.affiliation: Department of Signal and Systems, Chalmers University, Sweden.
authors.forename: Reza
authors.initials: R
authors.lastname: Shiee
authors.affiliation: Department of Medical Engineering, Islamic Azad University, Mashhad Branch, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Khalilzade
keywords: Absence Epilepsy; Ciprofloxacin; EEG; Wag/Rij