title: Novel BODIPY-based fluorescence turn-on sensor for Fe3+ and its bioimaging application in living cells.
abstract: A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe(3+) in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe(3+)-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe(3+) detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe(3+) in living cells.
authors.affiliation: Department of Chemistry and ‡CREOL, The College of Optics and Photonics, University of Central Florida , Orlando, Florida 32816, United States.
authors.forename: Binglin
authors.initials: B
authors.lastname: Sui
authors.forename: Simon
authors.initials: S
authors.lastname: Tang
authors.forename: Taihong
authors.initials: T
authors.lastname: Liu
authors.forename: Bosung
authors.initials: B
authors.lastname: Kim
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Belfield
mesh_terms: D001896:Boron Compounds / Q000737:chemistry*; D003584:Cytological Techniques / Q000379:methods*; D005456:Fluorescent Dyes / Q000737:chemistry*; D045325:HCT116 Cells; D006801:Humans; D007501:Iron / Q000032:analysis*; D008856:Microscopy, Fluorescence / Q000379:methods*
chemical_list: C095489:4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; D001896:Boron Compounds; D005456:Fluorescent Dyes; D007501:Iron
keywords: BODIPY; cell imaging; cryptand; fluorescent sensor; iron(III); metal ion sensor