title: Layer-by-layer assembled thin films and microcapsules of nanocrystalline cellulose for hydrophobic drug delivery.
abstract: A layer-by-layer (LbL) approach has been employed for the fabrication of multilayer thin films and microcapsules having nanofibrous morphology using nanocrystalline cellulose (NCC) as one of the components of the assembly. The applicability of these nanoassemblies as drug delivery carriers has been explored by the loading of an anticancer drug, doxorubicin hydrochloride, and a water-insoluble drug, curcumin. Doxorubicin hydrochloride, having a good water solubility, is postloaded in the assembly. In the case of curcumin, which is very hydrophobic and has limited solubility in water, a stable dispersion is prepared via noncovalent interaction with NCC prior to incorporation in the LbL assembly. The interaction of various other lipophilic drugs with NCC was analyzed theoretically by molecular docking in consideration of NCC as a general carrier for hydrophobic drugs.
authors.affiliation: Solid State and Structural Chemistry Unit, ‡Department of Chemical Engineering, Indian Institute of Science , Bangalore 560012, India.
authors.forename: Vaishakhi
authors.initials: V
authors.lastname: Mohanta
authors.forename: Giridhar
authors.initials: G
authors.lastname: Madras
authors.forename: Satish
authors.initials: S
authors.lastname: Patil
mesh_terms: D002214:Capsules / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry; D003474:Curcumin / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D012995:Solubility
chemical_list: D002214:Capsules; D004337:Drug Carriers; D004317:Doxorubicin; D002482:Cellulose; D048271:Chitosan; D003474:Curcumin
keywords: NCC; hydrophobic drug delivery; layer-by-layer; multilayers