title: MoonProt: a database for proteins that are known to moonlight.
abstract: Moonlighting proteins comprise a class of multifunctional proteins in which a single polypeptide chain performs multiple biochemical functions that are not due to gene fusions, multiple RNA splice variants or pleiotropic effects. The known moonlighting proteins perform a variety of diverse functions in many different cell types and species, and information about their structures and functions is scattered in many publications. We have constructed the manually curated, searchable, internet-based MoonProt Database (http://www.moonlightingproteins.org) with information about the over 200 proteins that have been experimentally verified to be moonlighting proteins. The availability of this organized information provides a more complete picture of what is currently known about moonlighting proteins. The database will also aid researchers in other fields, including determining the functions of genes identified in genome sequencing projects, interpreting data from proteomics projects and annotating protein sequence and structural databases. In addition, information about the structures and functions of moonlighting proteins can be helpful in understanding how novel protein functional sites evolved on an ancient protein scaffold, which can also help in the design of proteins with novel functions.
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
authors.forename: Mathew
authors.initials: M
authors.lastname: Mani
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Vaishak
authors.initials: V
authors.lastname: Amblee
authors.affiliation: Center for Pharmaceutical Biotechnology, College of Pharmacy, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Tanu
authors.initials: T
authors.lastname: Mathur
authors.affiliation: Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Grant
authors.initials: G
authors.lastname: Zwicke
authors.affiliation: Illinois Institute of Technology, 3300 S Federal St, Chicago, IL 60616, USA.
authors.forename: Shadi
authors.initials: S
authors.lastname: Zabad
authors.affiliation: Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Bansi
authors.initials: B
authors.lastname: Patel
authors.affiliation: Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA.
authors.forename: Jagravi
authors.initials: J
authors.lastname: Thakkar
authors.affiliation: Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA Department of Biological Sciences, MC567, University of Illinois at Chicago, 900 S. Ashland Ave., Chicago, IL 60607, USA cjeffery@uic.edu.
authors.forename: Constance J
authors.initials: CJ
authors.lastname: Jeffery
mesh_terms: D000818:Animals; D030562:Databases, Protein; D020407:Internet; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*
chemical_list: D011506:Proteins