title: A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins.
abstract: Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital and ‡Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School , Boston, Massachusetts 02115, United States.
authors.forename: Won Il
authors.initials: WI
authors.lastname: Choi
authors.forename: Nazila
authors.initials: N
authors.lastname: Kamaly
authors.forename: Lorena
authors.initials: L
authors.lastname: Riol-Blanco
authors.forename: In-Hyun
authors.initials: IH
authors.lastname: Lee
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Archana
authors.initials: A
authors.lastname: Swami
authors.forename: Cristian
authors.initials: C
authors.lastname: Vilos
authors.forename: Basit
authors.initials: B
authors.lastname: Yameen
authors.forename: Mikyung
authors.initials: M
authors.lastname: Yu
authors.forename: Jinjun
authors.initials: J
authors.lastname: Shi
authors.forename: Ira
authors.initials: I
authors.lastname: Tabas
authors.forename: Ulrich H
authors.initials: UH
authors.lastname: von Andrian
authors.forename: Sangyong
authors.initials: S
authors.lastname: Jon
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D002460:Cell Line; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D007328:Insulin / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D016753:Interleukin-10 / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D007004:Hypoglycemic Agents; D007328:Insulin; D011108:Polymers; D016753:Interleukin-10
keywords: Nanoparticles; biologics; solvent-free; therapeutic proteins; thermosponge