title: Assessment of the risk factors for impending fractures following radiotherapy for long bone metastases using CT scan-based virtual simulation: a retrospective study.
abstract: BACKGROUND
  Radiotherapy for long bone metastases (RTLB) can be complicated by fractures, which considerably increase morbidity and mortality. The aim of this study was to analyze the risk factors for impending fractures following radiotherapy for long bone metastases (RTLB) using CT scan-based virtual simulation.
  
  
  METHODS
  Forty-seven (47) patients were treated with RTLB (18 lung, 11 breast, 10 prostate and 8 other cancers) for a period of 18 months. Two doctors analyzed the CT images prior to radiation therapy. The impending fractures were then monitored and the correlation between bone scan parameters and fracture occurrence was analyzed.
  
  
  RESULTS
  The male gender ratio was 0.57 and the mean age 62.8 (33-93) years. The average size of the metastatic lesions was 32 (8-87) x 2 (6-81) x 52 (7-408) mm with cortical involvement (CI) in 66% of cases. The site was in the upper third of the bone in 92% of cases (28 femoral, 17 humeral and two tibial). Ten fractures occurred: two during RTLB, seven after one month and one after 6.6 months. The fractured lesions measured 48 (17-87) x 34 (12-66) x 76 (38-408) mm. The predictive parameters for fracture were osteolytic (39% vs. 10%; p=0.02) and permeative lesions (42% vs. 0%; p<0.0005), a Mirels score ≥9 (42% vs. 0%; p<0.0005), circumferential CI ≥30% (71% vs. 0%, p < 0.00001), CI ≥45 mm in height (67% vs. 0%, p<0.00001) and CI in thickness =100% (40% vs. 0%; p=0.0008). In the multivariate analysis, circumferential CI ≥30% was the only predictive parameter for fracture (p=0.00035; OR=62; CI 95%: 6.5-595). Overall survival was 91% and 40% at one month and twelve months respectively.
  
  
  CONCLUSIONS
  Prophylactic primary fixation surgery should always be considered when the circumferential CI ≥30%.
authors.affiliation: Medical Oncology Department, Centre Jean Perrin, Centre de Lutte contre le Cancer de la Région Auvergne, 58 Rue Montalembert, BP 392, Clermont-Ferrand, 63011, France. ztatar@chu-clermontferrand.fr.|Rheumatology Department, CHU Gabriel Montpied, 58 Rue Montalembert, BP 69, Clermont-Ferrand, 63003, France. ztatar@chu-clermontferrand.fr.|Département d'Oncologie Médicale, Hôpital de Jour, Centre Jean Perrin, Centre de Lutte contre le Cancer de la Région Auvergne, 58, rue Montalembert, B.P. 392, Clermont-Ferrand, 63011, France. ztatar@chu-clermontferrand.fr.
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Tatar
authors.affiliation: Rheumatology Department, CHU Gabriel Montpied, 58 Rue Montalembert, BP 69, Clermont-Ferrand, 63003, France. msoubrier@chu-clermontferrand.fr.
authors.forename: Martin
authors.initials: M
authors.lastname: Soubrier
authors.affiliation: Medical Oncology Department, Centre Jean Perrin, Centre de Lutte contre le Cancer de la Région Auvergne, 58 Rue Montalembert, BP 392, Clermont-Ferrand, 63011, France. anne-francoise.dillies@cjp.fr.
authors.forename: Anne Françoise
authors.initials: AF
authors.lastname: Dillies
authors.affiliation: Radiotherapy Department, Centre Jean Perrin, Centre de Lutte contre le Cancer de la Région Auvergne, 58 Rue Montalembert, BP 392, Clermont-Ferrand, 63011, France. pverrelle@chu-clermontferrand.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Verrelle
authors.affiliation: Orthopedic Surgery Department, CHU Gabriel Montpied, 58 Rue Montalembert, BP 69, Clermont-Ferrand, 63003, France. sboisgard@chu-clermontferrand.fr.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Boisgard
authors.affiliation: Radiotherapy Department, Centre Jean Perrin, Centre de Lutte contre le Cancer de la Région Auvergne, 58 Rue Montalembert, BP 392, Clermont-Ferrand, 63011, France. michel.lapeyre@cjp.fr.
authors.forename: Michel
authors.initials: M
authors.lastname: Lapeyre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000556:secondary; D003198:Computer Simulation; D005260:Female; D005500:Follow-Up Studies; D005598:Fractures, Spontaneous / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D011379:Prognosis; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000009:adverse effects*; D050397:Radiotherapy, Intensity-Modulated / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods*