title: Diastereoselective synthesis of functionalized spirocyclopropyl oxindoles via P(NMe2)3-mediated reductive cyclopropanation.
abstract: A P(NMe2)3-mediated reductive cyclopropanation reaction of α-keto esters or amides with isatin-derived alkenes has been developed, providing efficient and diastereoselective synthesis of highly functionalized spirocyclopropyl oxindoles bearing two all-carbon quaternary centers. This reaction also represents a complementary and nonmetal-involving protocol for the challenging cyclopropanation of electron-deficient alkenes.
authors.affiliation: College of Chemistry and Chemical Engineering, Taiyuan University of Technology , Taiyuan, 030024, P. R. China.
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
authors.forename: Changjiang
authors.initials: C
authors.lastname: Yang
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Liu
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Li
authors.forename: Zhengjie
authors.initials: Z
authors.lastname: He
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D004583:Electrons; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D003521:Cyclopropanes; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D007510:Isatin