title: Effects of body weight reduction on plasma leptin and adiponectin/leptin ratio in obese patients with type 1 diabetes mellitus.
abstract: The aim of this study was to explore the changes in the adipokines leptin and adiponectin in obese patients with type 1 diabetes mellitus (T1DM) who underwent seven days of fasting and 21 days of low-calorie diet (LCD). The plasma leptin and adiponectin concentrations were measured in 14 obese patients with T1DM at baseline, immediately after 7 days of fasting, and after 21 days of LCD. 13 non-obese patients with T1DM were studied only after an overnight fasting. Bioimpedance technique was used for determination of body composition. Obese T1DM patients lost 6.0 kg (6.0; 6.8) (median, 25 %; 75 %) and decreased their fat tissue after fasting and LCD. Plasma leptin in obese T1DM was significantly higher than in non-obese T1DM patients: 9.10 (5.06; 25.89) vs. 1.71 (1.12; 7.08) microg . l(-1) and transiently decreased immediately after fasting: 3.45 microg . l(-1) (1.47; 7.00), (P<0.05). Adiponectin/leptin ratio in obese T1DM was significantly lower than in non-obese T1DM patients: 0.67 (0.57; 1.49) vs. 3.50 (2.46; 6.30) . 10(3) and transiently increased immediately after fasting: 2.22 (1.26; 3.24) . 10(3), (P<0.05). We conclude that obese patients with T1DM are characterized by hyperleptinemia that is reduced by prolonged fasting, but only slightly affected by low calorie diet.
authors.affiliation: Department of Metabolic Care and Gerontology, University Hospital Hradec Králové and Medical Faculty Charles University in Hradec Králové, Hradec Králové, Czech Republic. musil@fnhk.cz.
authors.forename: F
authors.initials: F
authors.lastname: Musil
authors.forename: V
authors.initials: V
authors.lastname: Blaha
authors.forename: A
authors.initials: A
authors.lastname: Ticha
authors.forename: R
authors.initials: R
authors.lastname: Hyspler
authors.forename: M
authors.initials: M
authors.lastname: Haluzik
authors.forename: J
authors.initials: J
authors.lastname: Lesna
authors.forename: A
authors.initials: A
authors.lastname: Smahelova
authors.forename: L
authors.initials: L
authors.lastname: Sobotka
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000273:Adipose Tissue / Q000473:pathology; D000328:Adult; D001823:Body Composition; D031204:Caloric Restriction; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications* / Q000178:diet therapy; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism; D015309:Glucose Clamp Technique; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000209:etiology*; D015431:Weight Loss; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D005230:Fatty Acids, Nonesterified; D020738:Leptin; D005947:Glucose