title: Kctd12 and Ulk2 partner to regulate dendritogenesis and behavior in the habenular nuclei.
abstract: The habenular nuclei of the limbic system regulate responses, such as anxiety, to aversive stimuli in the environment. The habenulae receive inputs from the telencephalon via elaborate dendrites that form in the center of the nuclei. The kinase Ulk2 positively regulates dendritogenesis on habenular neurons, and in turn is negatively regulated by the cytoplasmic protein Kctd12. Given that the habenulae are a nexus in the aversive response circuit, we suspected that incomplete habenular dendritogenesis would have profound implications for behavior. We find that Ulk2, which interacts with Kctd12 proteins via a small proline-serine rich domain, promotes branching and elaboration of dendrites. Loss of Kctd12 results in increased branching/elaboration and decreased anxiety. We conclude that fine-tuning of habenular dendritogenesis during development is essential for appropriate behavioral responses to negative stimuli.
authors.affiliation: Vanderbilt University, Department of Biological Sciences, Nashville, Tennessee, United States of America.
authors.forename: Stacey
authors.initials: S
authors.lastname: Lee
authors.affiliation: Vanderbilt University Medical Center, Department of Molecular Physiology and Biophysics, Nashville, Tennessee, United States of America.
authors.forename: Patrick
authors.initials: P
authors.lastname: Page-McCaw
authors.affiliation: Vanderbilt University, Department of Biological Sciences, Nashville, Tennessee, United States of America.
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Gamse
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism / Q000473:pathology; D001522:Behavior, Animal; D027682:Cation Transport Proteins / Q000378:metabolism*; D003712:Dendrites / Q000378:metabolism*; D004777:Environment; D055785:Gene Knockdown Techniques; D019262:Habenula / Q000166:cytology* / Q000254:growth & development; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D017434:Protein Structure, Tertiary; D015027:Zebrafish / Q000254:growth & development / Q000378:metabolism; D029961:Zebrafish Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*
chemical_list: D027682:Cation Transport Proteins; D009419:Nerve Tissue Proteins; D029961:Zebrafish Proteins; C472905:kctd12.1 protein, zebrafish; D017346:Protein Serine-Threonine Kinases; C000598728:Ulk2 protein, zebrafish