title: Preliminary 1 month stability screening of cosmetic multiple emulsions (W/O/W) prepared using cetyl dimethicone copolyol and Polysorbate 80.
abstract: OBJECTIVE
  The objective of this work was to develop W/O/W emulsions with different concentration of paraffin oil, lipophilic (cetyl dimethicone copolyol) and hydrophilic emulsifiers (polysorbate 80) and to check their stability at different storage conditions.
  
  
  METHODS
  Approximately, 20 formulations (W/O/W) multiple emulsions were prepared, and their stability was checked at different storage conditions for the period of 30 days. Stability of some multiple emulsions ME12, ME13, ME14, ME19 and ME20 was also checked with carbomer as viscosity-enhancing agent. Microscopic analysis for droplet size determination and rheological characterization of most stable multiple emulsions, that is, ME20 were also performed.
  
  
  RESULTS
  It was observed that stability of multiple emulsion increases with the addition of gelling agent. Formulation (ME20) with 13.6% paraffin oil, 2.4% cetyl dimethicone copolyol and 0.8% polysorbate 80 was found more stable at 25°C and 40°C for the period of 30 days. Rheological analysis indicated a decrease in viscosity with the passage of time, while droplet size analysis indicated an increase in droplet size with the passage of time.
  
  
  CONCLUSIONS
  As a conclusion of this work, a stable multiple emulsion with 13.6% paraffin oil, 2.4% cetyl dimethicone copolyol and 0.8% polysorbate 80 can be formulated and can be further studied for any active ingredient for cosmetic purposes.
authors.affiliation: Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
authors.forename: H
authors.initials: H
authors.lastname: Khan
authors.forename: N
authors.initials: N
authors.lastname: Akhtar
authors.forename: T
authors.initials: T
authors.lastname: Mahmood
authors.forename: A
authors.initials: A
authors.lastname: Jameel
authors.forename: S
authors.initials: S
authors.lastname: Mohsin
mesh_terms: D003358:Cosmetics; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004655:Emulsions; D011136:Polysorbates / Q000737:chemistry*
chemical_list: D003358:Cosmetics; D004129:Dimethylpolysiloxanes; D004655:Emulsions; D011136:Polysorbates; C501844:dimethicone
keywords: W/O/W emulsion; carbomer; cetyl dimethicone copolyol; droplet size; polysorbate 80; rheology; stability; triethanolamine