title: 5-Aza-CdR delivers a gene body blow.
abstract: In this issue of Cancer Cell, Yang et al. describe a causal relationship between gene body methylation and gene expression and a role for genic methylation in response to clinical DNA methylation inhibitors, which suggests that the mechanism of action of these inhibitors includes gene body hypomethylation-induced downregulation of cancer-associated genes.
authors.affiliation: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Medical Scientist Training Program, University of Washington School of Medicine, Seattle, WA 98195, USA; Molecular & Cellular Biology Graduate Program, University of Washington, Seattle, WA 98195, USA.
authors.forename: Sivakanthan
authors.initials: S
authors.lastname: Kasinathan
authors.affiliation: Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Seattle, WA 98109, USA. Electronic address: steveh@fhcrc.org.
authors.forename: Steven
authors.initials: S
authors.lastname: Henikoff
mesh_terms: D001374:Azacitidine / Q000378:metabolism*; D019175:DNA Methylation; D015536:Down-Regulation; D015870:Gene Expression; D006801:Humans; D009369:Neoplasms / Q000235:genetics
chemical_list: D001374:Azacitidine