title: In situ preactivation strategies for the expeditious synthesis of oligosaccharides: A review.
abstract: Carbohydrates have gained increasing appreciation over the last few decades for their fundamental roles in all essential areas of life. As a result, there has been a surge of activity in synthetic glycosylation strategies to construct useful oligosaccharides. This review evaluates the advances in synthetic carbohydrate chemistry, specifically preactivation methodologies, stereoselective β-mannosylations, and an automated, electrochemical preactivation method. Also discussed is the use of preactivation as a tool to study reactive intermediates, and applications of preactivation protocols in the one pot-synthesis of a hyaluronic acid decasaccharide and one-pot synthesis of a tristearoyl lipomannan containing a pseudotrisaccharide.
authors.affiliation: Department of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606.
authors.forename: Samantha K
authors.initials: SK
authors.lastname: Bouhall
authors.affiliation: Department of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Sucheck