title: DNA cleavage by oxymyoglobin and cysteine-introduced metmyoglobin.
abstract: Double stranded DNA was cleaved oxidatively by incubation with oxygenated myoglobin, and Lys96Cys sperm whale myoglobin in its stable ferric form functioned as an artificial nuclease under air by formation of an oxygenated species, owing to electron transfer from the SH group of the introduced cysteine to the heme.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan. hirota@ms.naist.jp.
authors.forename: Megha Subhash
authors.initials: MS
authors.lastname: Deshpande
authors.forename: Sendy
authors.initials: S
authors.lastname: Junedi
authors.forename: Halan
authors.initials: H
authors.lastname: Prakash
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nagao
authors.forename: Masaru
authors.initials: M
authors.lastname: Yamanaka
authors.forename: Shun
authors.initials: S
authors.lastname: Hirota
mesh_terms: D003545:Cysteine / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage; D008786:Metmyoglobin / Q000737:chemistry*; D009211:Myoglobin / Q000737:chemistry*
chemical_list: D009211:Myoglobin; C017595:oxymyoglobin; D008786:Metmyoglobin; D004247:DNA; D003545:Cysteine