title: Translational control in germline stem cell development.
abstract: Stem cells give rise to tissues and organs during development and maintain their integrity during adulthood. They have the potential to self-renew or differentiate at each division. To ensure proper organ growth and homeostasis, self-renewal versus differentiation decisions need to be tightly controlled. Systematic genetic studies in Drosophila melanogaster are revealing extensive regulatory networks that control the switch between stem cell self-renewal and differentiation in the germline. These networks, which are based primarily on mutual translational repression, act via interlocked feedback loops to provide robustness to this important fate decision.
authors.affiliation: Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016.
authors.forename: Maija
authors.initials: M
authors.lastname: Slaidina
authors.affiliation: Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 Howard Hughes Medical Institute and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016 Ruth.Lehmann@med.nyu.edu.
authors.forename: Ruth
authors.initials: R
authors.lastname: Lehmann
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics; D005260:Female; D053263:Gene Regulatory Networks; D005854:Germ Cells / Q000378:metabolism*; D008297:Male; D051379:Mice; D010053:Ovary / Q000166:cytology* / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics*; D013737:Testis / Q000166:cytology* / Q000378:metabolism