title: Drug-induced visceral angioedema.
abstract: Angioedema associated with angiotensin converting enzyme inhibitors (ACEIs) is due to the accumulation of bradykinin and its metabolites. Angiotensin receptor blockers (ARBs) produce anti-hypertensive effects by blocking the angiotensin II AT1 receptor action; hence bradykinin-related side effects are not expected. However, we notice the occurrence of ARB-induced angioedema as not a very rare side effect. Visceral drug-induced angioedema has been reported with ACEIs, not with ARBs. This underlying review will help educate readers on the pathophysiology and recent guidelines pertaining to ACEI- and ARB-induced visceral angioedema.
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, McKeesport, PA, USA.
authors.forename: Prashanth M
authors.initials: PM
authors.lastname: Thalanayar
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, McKeesport, PA, USA.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ghobrial
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, McKeesport, PA, USA.
authors.forename: Fritz
authors.initials: F
authors.lastname: Lubin
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, McKeesport, PA, USA.
authors.forename: Reena
authors.initials: R
authors.lastname: Karnik
authors.affiliation: Department of Internal Medicine, University of Pittsburgh Medical Center, McKeesport, PA, USA.
authors.forename: Robin
authors.initials: R
authors.lastname: Bhasin
keywords: angiotensin converting enzyme inhibitor; angiotensin receptor blocker; intestinal angioedema; visceral angioedema