title: Haematopoietic stem cell transplantation for relapsed or refractory anaplastic large cell lymphoma: a study of children and adolescents in Japan.
abstract: To evaluate haematopoietic stem cell transplantation (HSCT) in children and adolescents, we reviewed the records of 47 patients who were ≤18 years, had relapsed or refractory anaplastic large cell lymphoma, and received HSCT between 1990 and 2010. At HSCT, complete remission (CR) was less common in allogeneic HSCT recipients (n = 24) than in autologous HSCT recipients (n = 23) (P = 0·01). The autologous and allogeneic HSCT groups differed in terms of 5-year event-free survival (EFS) (38% vs. 50%, P = 0·63), cumulative incidence of progress or relapse (49% vs. 28%, P = 0·25), and treatment-related mortality (12% vs. 25%, P = 0·40). However, these differences were not significant. Patients with non-CR at autologous HSCT had a significantly lower EFS rate (14% vs. 48%, P = 0·03). Conversely, although those with non-CR at allogeneic HSCT had a lower EFS rate, this was not significant (44% vs. 63%, P = 0·26). Reduced-intensity conditioning regimens were used for three of the 16 allogeneic HSCTs received by patients with non-CR. These three patients achieved CR, surviving 32-65 months after HSCT. These results demonstrated that allogeneic HSCT might be a treatment option for patients who do not achieve CR through conventional chemotherapy.
authors.affiliation: Department of Paediatrics, National Kyushu Cancer Centre, Fukuoka, Japan.
authors.forename: Reiji
authors.initials: R
authors.lastname: Fukano
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Ryoji
authors.initials: R
authors.lastname: Kobayashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Mitsui
authors.forename: Naoto
authors.initials: N
authors.lastname: Fujita
authors.forename: Fuminori
authors.initials: F
authors.lastname: Iwasaki
authors.forename: Junji
authors.initials: J
authors.lastname: Suzumiya
authors.forename: Motoaki
authors.initials: M
authors.lastname: Chin
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Goto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Junichi
authors.initials: J
authors.lastname: Hara
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Park
authors.forename: Masami
authors.initials: M
authors.lastname: Inoue
authors.forename: Yuhki
authors.initials: Y
authors.lastname: Koga
authors.forename: Jiro
authors.initials: J
authors.lastname: Inagaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Sakamaki
authors.forename: Souichi
authors.initials: S
authors.lastname: Adachi
authors.forename: Keisei
authors.initials: K
authors.lastname: Kawa
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
authors.forename: Ritsuro
authors.initials: R
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D064591:Allografts; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000628:therapy*; D012008:Recurrence; D012189:Retrospective Studies; D016879:Salvage Therapy; D019172:Transplantation Conditioning; D014182:Transplantation, Autologous
keywords: adolescents; anaplastic large cell lymphoma; children; haematopoietic stem cell transplantation; reduced-intensity conditioning