title: Influence of scan duration on the estimation of pharmacokinetic parameters for breast lesions: a study based on CAIPIRINHA-Dixon-TWIST-VIBE technique.
abstract: OBJECTIVE
  To evaluate the influence of scan duration on pharmacokinetic parameters and their performance in differentiating benign from malignant breast lesions.
  
  
  METHODS
  Dynamic breast imaging was performed on a 3.0-T MR system using a prototype CAIPIRINHA-Dixon-TWISTVIBE (CDT-VIBE) sequence with a temporal resolution of 11.9 s. Enrolled in the study were 53 women with 55 lesions (26 benign and 29 malignant). Pharmacokinetic parameters (Ktrans, ve , kep and iAUC) were calculated for various scan durations from 1 to 7 min after injection of contrast medium using the Tofts model.
  
  
  RESULTS
  Ktrans, kep and ve calculated from the 1-min dataset were significantly different from those calculated from the other datasets. In benign lesions, Ktrans, kep and ve were significantly different only between 1 min and 2 min (corrected P > 0.05), but in malignant lesions there were significant differences for any of the comparisons up to 6 min vs. 7 min (corrected P > 0.05). There were no significant differences in AUCs for any of the parameters (P > 0.05).
  
  
  CONCLUSIONS
  In breast dynamic contrast-enhanced MRI the scan duration has a significant impact on pharmacokinetic parameters, but the diagnostic ability may not be significantly affected. A scan duration of 5 min after injection of contrast medium may be sufficient for calculation of Tofts model pharmacokinetic parameters.
  
  
  CONCLUSIONS
  • Scan duration of DCE-MRI breast imaging has a significant impact on pharmacokinetic parameters • A scan duration of less than 2 min results in spurious parameter estimates • The initial 2 min are important for both benign and malignant lesions • In malignant lesions the impact extends to 4 - 6 min • The differentiation ability of parameters may not be affected by scan duration.
authors.affiliation: Department of MR Imaging, Shandong Medical Imaging Research Institute, Shandong University, 324 Jingwu Road, Jinan, Shandong, 250021, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Hao
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Guangbin
authors.initials: G
authors.lastname: Wang
authors.forename: Cuiyan
authors.initials: C
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis*; D003287:Contrast Media / Q000493:pharmacokinetics*; D003937:Diagnosis, Differential; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D003287:Contrast Media