title: Side-effects of anti-inflammatory therapy in uveitis.
abstract: Uveitis is a group of inflammatory ocular conditions that cause significant visual morbidity around the world. Many of the cases of blindness secondary to uveitis can be avoided with adequate and aggressive management of the intraocular inflammation. Steroids have been utilized in the treatment of noninfectious uveitis for more than 60 years, but their chronic use is associated with severe ocular and systemic side-effects. Ophthalmologists are often not familiar with the systemic steroid-sparing agents available for the management of ocular inflammation and depend primarily on the use of corticosteroids. In this article, we review the most common agents utilized in the treatment of uveitis and their side-effect profiles.
authors.affiliation: Department of Ophthalmology , Massachusetts Eye and Ear Infirmary, Boston, Massachusetts , USA and.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Uchiyama
authors.forename: George N
authors.initials: GN
authors.lastname: Papaliodis
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Lobo
authors.forename: Lucia
authors.initials: L
authors.lastname: Sobrin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D056747:Immunomodulation; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D014605:Uveitis / Q000188:drug therapy*
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents
keywords: Eye; immunomodulation; immunomodulatory therapy; immunosuppression; inflammation