title: Studies towards the synthesis of medermycin via Dötz benzannulation.
abstract: The C-arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso bromination and nitrile substitution in good overall yields.
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, China.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Qu
authors.forename: Erqing
authors.initials: E
authors.lastname: Tang
authors.forename: Richard
authors.initials: R
authors.lastname: Loeppky
authors.forename: Zixin
authors.initials: Z
authors.lastname: Deng
authors.forename: Shon R
authors.initials: SR
authors.lastname: Pulley
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Hong
mesh_terms: D015394:Molecular Structure; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D000095622:Benzoisochromanequinones
chemical_list: D009285:Naphthoquinones; C013104:medermycin; D000095622:Benzoisochromanequinones
keywords: C-arylglycoside; Dötz benzannulation; Fischer carbene complex; Streptomyces sp; ipso bromination