title: Tensor total-variation regularized deconvolution kegularlzea ueconvolution for efficient low-dose CT perfusion.
abstract: Acute brain diseases such as acute stroke and transit ischemic attacks are the leading causes of mortality and morbidity worldwide, responsible for 9% of total death every year. 'Time is brain' is a widely accepted concept in acute cerebrovascular disease treatment. Efficient and accurate computational framework for hemodynamic parameters estimation can save critical time for thrombolytic therapy. Meanwhile the high level of accumulated radiation dosage due to continuous image acquisition in CT perfusion (CTP) raised concerns on patient safety and public health. However, low-radiation will lead to increased noise and artifacts which require more sophisticated and time-consuming algorithms for robust estimation. We propose a novel efficient framework using tensor total-variation (TTV) regularization to achieve both high efficiency and accuracy in deconvolution for low-dose CTP. The method reduces the necessary radiation dose to only 8% of the original level and outperforms the state-of-art algorithms with estimation error reduced by 40%. It also corrects over-estimation of cerebral blood flow (CBF) and under-estimation of mean transit time (MTT), at both normal and reduced sampling rate. An efficient computational algorithm is proposed to find the solution with fast convergence.
authors.forename: Ruogu
authors.initials: R
authors.lastname: Fang
authors.forename: Pina C
authors.initials: PC
authors.lastname: Sanelli
authors.forename: Shaoting
authors.initials: S
authors.lastname: Zhang
authors.forename: Tsuhan
authors.initials: T
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002533:Cerebral Angiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*