title: Low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network.
abstract: Solute carrier family 2 (facilitated glucose/fructose transporter) member 5 (SLC2A5)-inhibited seven different molecular Pearson mutual-positive-correlation networks constructed by 24 overlapping molecules from 368 GRNInfer and 34 Pearson under SLC2A5 CC ≤-0.25 in low human normal adjacent tissues were compared with high lung adenocarcinoma. Based on GO, KEGG, GenMAPP, BioCarta, and disease databases, our result showed that low SLC2A5-inhibited network included Golgi apparatus of AP1M2_1; cell cycle of CUL7, SAC3D1; protein amino acid dephosphorylation of STYXL1; pro-B cell-cell differentiation of SOX4_3; and FAD biosynthesis of FLAD1. Thus, we propose low glucose transporter SLC2A5-inhibited human normal adjacent lung adenocarcinoma cytoplasmic pro-B cell development mechanism network through repression of protein amino acid dephosphorylation to FAD biosynthesis.
authors.affiliation: Biomedical Center, School of Electronic Engineering, Beijing University of Posts and Telecommunications, Beijing, 100876, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: You
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Juxiang
authors.initials: J
authors.lastname: Huang
authors.forename: Minghu
authors.initials: M
authors.lastname: Jiang
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Chen
authors.forename: Yangming
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhenfu
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000077192:Adenocarcinoma of Lung; D001402:B-Lymphocytes / Q000502:physiology; D053898:Biosynthetic Pathways; D005182:Flavin-Adenine Dinucleotide / Q000096:biosynthesis; D015870:Gene Expression; D051296:Glucose Transporter Type 5 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000276:immunology / Q000378:metabolism*
chemical_list: D051296:Glucose Transporter Type 5; C495726:SLC2A5 protein, human; D005182:Flavin-Adenine Dinucleotide