title: Association of CRP gene polymorphism with CRP levels and Coronary Artery Disease in Type 2 Diabetes in Ahvaz, southwest of Iran.
abstract: BACKGROUND
  We evaluated the association between four polymorphisms in the CRP gene with serum C-reactive protein (CRP) levels, prevalence and severity of coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) patients.
  
  
  METHODS
  We performed coronary angiography for 308 T2DM patients and classified them into two groups: T2DM with CAD and T2DM without CAD. All patients were from Ahvaz, Iran. serum levels of CRP, glucose and lipid profile were measured. Genotyping was performed by PCR/RFLP, and the severity of coronary artery disease was determined by Gensini score.
  
  
  RESULTS
  The GG genotype of SNP rs279421 was associated with the increased risk of CAD (OR= 2.38; 95% CI: 1.12- 5.8; p= 0.02) and CA, TT, TA genotypes and A allele of SNP rs3091244 and GA genotypes and A allele of SNP rs3093062 were significantly associated with increased CRP levels. None of genotypes or alleles was associated with Gensini score. We found that the haplotype 7 (AGCG) was associated with decreased risk of CAD (OR= 0.11; 95% CI: 0.02, 0.66; p= 0.017) and the Gensini score was correlated with increased levels of CRP, only in CAD group.
  
  
  CONCLUSIONS
  Although genetic polymorphisms were influenced on serum RP levels, none of the alleles and genotypes raising or falling C-reactive protein levels was consistently associated with an increased prevalence of CAD or protected from that.
authors.affiliation: Cellular and Molecular Research Center, Ahvaz Jondishapour University of Medical Sciences, Ahwaz, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ghaffari
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Askari Sede
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Nadereh
authors.initials: N
authors.lastname: Rashtchizadeh
authors.affiliation: Hyperlipidemia Research Center, Ahvaz Jondishapour University of Medical Sciences, Ahvaz, Iran.
authors.forename: Ghorban
authors.initials: G
authors.lastname: Mohammadzadeh
authors.affiliation: Department of Cardiology, Imam Khomeini Hospital, Ahvaz, Iran.
authors.forename: Shahla
authors.initials: S
authors.lastname: Majidi
keywords: C-reactive protein; Coronary artery disease; Gensini score; Polymorphism; Type2 diabetes mellitus