title: [Expression of Versican and its clinical significance in gastric carcinoma].
abstract: OBJECTIVE
  To investigate the expression of Versican in gastric carcinoma and its relationship with tumor angiogenesis.
  
  
  METHODS
  Protein expression of Versican, vascular endothelial growth factor and CD34 was evaluated by immunohistochemistry (EliVision method) in 80 cases of gastric carcinoma and 30 samples of normal gastric tissue.
  
  
  RESULTS
  There were statistically significant differences in the expression of Versican, vascular endothelial growth factor and CD34 between gastric carcinoma and normal gastric tissue (P < 0.05). The expression of Versican was seen mainly in fibroblasts of the tumor and was correlated with tumor differentiation, clinical stage and lymph node metastasis (P < 0.05), whereas vascular endothelial growth factor was primarily seen in the cytoplasm of the tumor cells and correlated with tumor differentiation, clinical stage, Lauren classification and lymph node metastasis (P < 0.05). MVD was correlated with tumor differentiation, clinical stage, Lauren classification, depth of tumor invasion and lymph node metastasis (P < 0.05). In addition, positive correlation of Versican and VEGF protein expression was found in tumor cells (r = 0.467, P < 0.01).
  
  
  CONCLUSIONS
  The expression of both Versican and vascular endothelial growth factor is closely associated with tumor angiogenesis in gastric carcinoma.
authors.affiliation: Department of Pathology, the People's Hospital of Zhengzhou, Zhengzhou 450003, China.
authors.forename: Miling
authors.initials: M
authors.lastname: Yang
authors.forename: Lifeng
authors.initials: L
authors.lastname: Wang
authors.forename: Jinhua
authors.initials: J
authors.lastname: Yang
authors.affiliation: E-mail: yanggy54@126.com.
authors.forename: Guangying
authors.initials: G
authors.lastname: Yang
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D009363:Neoplasm Proteins / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D011379:Prognosis; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D053675:Versicans / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34; D009363:Neoplasm Proteins; D042461:Vascular Endothelial Growth Factor A; D053675:Versicans