title: A paroxysmal nocturnal haemoglobinuria progress with waldenström macroglobulinemia along with T cell monoclonal expansion.
abstract: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematopoietic stem cell clinical disease, which has been reported associated with T cell monoclonal expansion and plasma cell dyscrasias. There we reported a case with a 20-year clinical history of PNH. Lately diagnosis of Waldenström macroglobulinemia with the offered evidences of bone marrow examination, flow cytometry and immunofixation electrophoresis. T cell monoclonal expansion was established by polymerase chain reaction. Meanwhile the decreased expression of CD55 and CD59 on neutrophils and erythrocyte were obvious observed. Here we describe the diagnostic evaluation of this patient and provide a brief review of such clonal disorder.
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Huanling
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xianglong
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Chunli
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Dewan
authors.initials: D
authors.lastname: Zhao
authors.affiliation: Department of Haematology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xiujin
authors.initials: X
authors.lastname: Wu
keywords: Monoclonal T cell proliferation; Paroxysmal nocturnal hemoglobinuria; Waldenström macroglobulinemia