title: A novel Pd-catalyzed N-dealkylative carbonylation of tertiary amines for the preparation of amides.
abstract: A novel and convenient protocol for the formation of amides via palladium-catalyzed N-dealkylative carbonylation of alkyl tertiary amines has been developed. In the presence of PdCl2(PhCN)2, CuO, PhCN and CO, a range of substituents on both aryl iodides and alkyl tertiary amines were compatible with the reaction to afford a series of N,N-disubstituted amides in moderate to excellent yields.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China. dcl78@wzu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Fang
authors.forename: Xu-Hong
authors.initials: XH
authors.lastname: Gao
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Deng
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D007659:Ketones; D010165:Palladium; D009584:Nitrogen