title: Conducting polymer nanoparticles decorated with collagen mimetic peptides for collagen targeting.
abstract: We report on the formation of conducting polymer nanoparticles (CPNs), stabilized by a collagen mimetic peptide (CMP)-polymer amphiphile. CPNs ranging from ∼15 to 40 nm were readily accessible upon modifying the amphiphile concentration. Surface presentation of CMPs on CPN precluded intra-/inter-particle trimerization, while preserving their ability to target collagen without pre-activation.
authors.affiliation: Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA. herrera@jhu.edu.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Santos
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Heidi R
authors.initials: HR
authors.lastname: Culver
authors.forename: Michael S
authors.initials: MS
authors.lastname: Yu
authors.forename: Margarita
authors.initials: M
authors.lastname: Herrera-Alonso
mesh_terms: D000818:Animals; D040761:Biomimetic Materials; D003094:Collagen / Q000032:analysis* / Q000737:chemistry; D003315:Cornea / Q000737:chemistry; D005449:Fluorenes / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*
chemical_list: D005449:Fluorenes; D010455:Peptides; D011108:Polymers; C556103:poly((9,9-dioctylfluorenyl-2,7-diyl)-co-(1,4-benzo-(2,1',3)-thiadiazole)); D003094:Collagen