title: Cancer metabolism and elevated O-GlcNAc in oncogenic signaling.
abstract: O-Linked β-N-acetylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. Analogous to phosphorylation, O-GlcNAcylation plays crucial regulatory roles in cellular signaling. Recent work indicates that increased O-GlcNAcylation is a general feature of cancer and contributes to transformed phenotypes. In this minireview, we discuss how hyper-O-GlcNAcylation may be linked to various hallmarks of cancer, including cancer cell proliferation, survival, invasion, and metastasis; energy metabolism; and epigenetics. We also discuss potential therapeutic modulation of O-GlcNAc levels in cancer treatment.
authors.affiliation: From the Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Ma
authors.affiliation: From the Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102 keith.vosseller@drexelmed.edu.
authors.forename: Keith
authors.initials: K
authors.lastname: Vosseller
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D063646:Carcinogenesis; D044127:Epigenesis, Genetic; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000117:Acetylglucosamine
keywords: Cancer; Glycosylation; Metabolism; O-GlcNAc; O-GlcNAcylation; OGT; Signal Transduction; Warburg Effect