title: A joint model for repeated events of different types and multiple longitudinal outcomes with application to a follow-up study of patients after kidney transplant.
abstract: This paper presents an extension of the joint modeling strategy for the case of multiple longitudinal outcomes and repeated infections of different types over time, motivated by postkidney transplantation data. Our model comprises two parts linked by shared latent terms. On the one hand is a multivariate mixed linear model with random effects, where a low-rank thin-plate spline function is incorporated to collect the nonlinear behavior of the different profiles over time. On the other hand is an infection-specific Cox model, where the dependence between different types of infections and the related times of infection is through a random effect associated with each infection type to catch the within dependence and a shared frailty parameter to capture the dependence between infection types. We implemented the parameterization used in joint models which uses the fitted longitudinal measurements as time-dependent covariates in a relative risk model. Our proposed model was implemented in OpenBUGS using the MCMC approach.
authors.affiliation: Department of Clinical Epidemiology, Biostatistics and Bioinformatics Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: Jammbe Z
authors.initials: JZ
authors.lastname: Musoro
authors.forename: Ronald B
authors.initials: RB
authors.lastname: Geskus
authors.forename: Aeilko H
authors.initials: AH
authors.lastname: Zwinderman
mesh_terms: D000465:Algorithms; D001699:Biometry / Q000379:methods*; D017252:CD3 Complex / Q000378:metabolism; D005500:Follow-Up Studies; D006801:Humans; D007239:Infections / Q000209:etiology / Q000276:immunology; D016030:Kidney Transplantation / Q000009:adverse effects; D007694:Killer Cells, Natural / Q000166:cytology; D016013:Likelihood Functions; D008137:Longitudinal Studies; D015233:Models, Statistical; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D017252:CD3 Complex
keywords: Infection-specific hazards; Joint modeling; Mixed effects model; Multiple longitudinal outcomes; Multiple repeating events