title: Ectopic expression of B and T lymphocyte attenuator in gastric cancer: a potential independent prognostic factor in patients with gastric cancer.
abstract: It has been confirmed that B and T lymphocyte attenuator (BTLA; also known as CD272) is a novel co--inhibitory molecule that exhibits a critical role in restraining cell-mediated antitumor immunity. The present study aimed to investigate the expression and prognostic significance of BTLA in gastric adenocarcinoma. Immunohistochemical (IHC) staining was performed to investigate BTLA expression in gastric cancer tissues and normal mucosal tissues. In total, 123 pathologically confirmed specimens were obtained from stage IIIa gastric cancers. A correlation test, Kaplan-Meier curves, and a Cox proportional hazards regression model were used to analyze the data. No BTLA staining in the normal tissues was found, while BTLA-stained gastric carcinoma cells were detected in 75.6% (93/123) of the gastric cancer specimens. High expression levels of BTLA were detected in 31.7% (39/123) of the specimens, while low expression levels were detected in 68.3% (84/123) of the specimens. High BTLA expression levels were associated with shorter survival time, as confirmed by univariate and multivariate analyses. These findings provide a basis for the concept that high BTLA expression levels in gastric cancer, identified by IHC, are an independent biomarker for the poor prognosis of patients with gastric cancer.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Xing-Yu
authors.initials: XY
authors.lastname: Feng
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Xi-Zhi
authors.initials: XZ
authors.lastname: Wen
authors.affiliation: Department of Infectious Diseases, The Third Affiliated Hospital, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Tan
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Hou
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Ding
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Jun
authors.initials: J
authors.lastname: Dong
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Ying-Bo
authors.initials: YB
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China.
authors.forename: Xiao-Shi
authors.initials: XS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011379:Prognosis; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000401:mortality; D047368:Tumor Burden
chemical_list: C482586:BTLA protein, human; D014408:Biomarkers, Tumor; D011971:Receptors, Immunologic