title: Population data of 30 insertion-deletion markers in four Chinese populations.
abstract: In this study, we assessed 30 insertion-deletion polymorphisms (Indels) (Investigator DIPplex® kit) in four Chinese populations (n = 952) and evaluated their usefulness in forensic genetic applications. After the Bonferroni correction at a 95 % significance level (p = 0.0017), there were no deviations from the Hardy-Weinberg equilibrium observed except for the HLD114 locus in the Tibetan ethnic group studied. A high level of discrimination power was observed for the DIPplex® kit in four sample populations (CDP > 0.9999) and the combined random match probabilities (CMP) were in the range of 1.4766 × 10(-11) to 5.2742 × 10(-13). Four Indels have been selected for further analyses as possible ancestry informative single nucleotide polymorphisms. The study support that the Investigator DIPplex® kit provides a powerful supplement to standard short tandem repeat-based kits for individual identification and kinship analysis in the Chinese population.
authors.affiliation: Department of Radiology, First Affiliated Hospital, Medical College of Shantou University, Shantou, China.
authors.forename: Meisen
authors.initials: M
authors.lastname: Shi
authors.forename: Yaju
authors.initials: Y
authors.lastname: Liu
authors.forename: Rufeng
authors.initials: R
authors.lastname: Bai
authors.forename: Lizhe
authors.initials: L
authors.lastname: Jiang
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Lv
authors.forename: Shuhua
authors.initials: S
authors.lastname: Ma
mesh_terms: D044466:Asian People / Q000235:genetics; D002681:China; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D054643:INDEL Mutation; D008297:Male; D016133:Polymerase Chain Reaction