title: Sleep disturbances and nocturnal symptoms: relationships with quality of life in a population-based sample of women with interstitial cystitis/bladder pain syndrome.
abstract: OBJECTIVE
  To characterize the nature and impact of sleep disturbances on quality of life (QOL) in women with interstitial cystitis/bladder pain syndrome (IC/BPS).
  
  
  METHODS
  Participants were 3,397 women from a telephone probability survey who met IC/BPS symptom criteria. Sleep quality, duration, and IC/BPS nocturnal symptoms (i.e., trouble sleeping due to bladder pain, urgency, or needing to use the bathroom), general QOL (mental and physical health and sexual functioning), and IC/BPS QOL impairment were assessed via self-report during telephone interview.
  
  
  RESULTS
  Over half of the sample reported poor sleep quality, sleep duration ≤ 6 hours, or trouble sleeping due to IC/BPS symptoms. After covariate adjustment, short sleep duration was significantly associated with greater IC/BPS QOL impairment (β = -0.04; p < 0.001) and poorer self-reported physical health (β = 1.86; p < 0.001). Poor sleep quality was significantly associated with greater IC/BPS QOL impairment (β = 0.06; p < 0.001), poorer self-reported physical health (β = -2.86; p < 0.001), and greater sexual dysfunction (β = -0.04; p < 0.05). IC/BPS nocturnal symptoms were significantly associated with greater IC/BPS impairment (β = 0.14; p < 0.001), poorer physical health (β = -2.76; p < 0.001) and mental health (β = 0.52; p < 0.01), and greater sexual dysfunction (β = -0.10; p < 0.001), after covariate adjustment. After further adjustment for IC/BPS nocturnal symptoms, we found that poor sleep quality and short sleep duration were independent correlates of poor self-reported physical health.
  
  
  CONCLUSIONS
  Poor sleep quality and short sleep duration, as well as disorder-specific sleep disturbances, are highly prevalent in women with IC/BPS and are associated with poorer disease-specific and general QOL.
authors.affiliation: RAND Corporation.
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Troxel
authors.affiliation: RAND Corporation.
authors.forename: Marika
authors.initials: M
authors.lastname: Booth
authors.affiliation: Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Buysse
authors.affiliation: RAND Corporation.
authors.forename: Marc N
authors.initials: MN
authors.lastname: Elliott
authors.affiliation: Department of Urology, University of Michigan, Ann Arbor, MI.
authors.forename: Anne M
authors.initials: AM
authors.lastname: Suskind
authors.affiliation: Department of Urology, University of Michigan, Ann Arbor, MI.
authors.forename: J Quentin
authors.initials: JQ
authors.lastname: Clemens
authors.affiliation: RAND Corporation.
authors.forename: Sandra H
authors.initials: SH
authors.lastname: Berry
mesh_terms: D018856:Cystitis, Interstitial / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000150:complications*; D011788:Quality of Life; D012893:Sleep Wake Disorders / Q000150:complications*; D011795:Surveys and Questionnaires; D013577:Syndrome; D001743:Urinary Bladder
keywords: bladder symptoms; interstitial cystitis; pain; sleep duration; sleep quality; women's health