title: [The role of intraperitoneal macrophages in the progression of peritoneal carcinomatosis from gastric cancer].
abstract: Tumor-associated macrophages(TAM)of the M2 phenotype(M2 macrophage)promote tumor proliferation and are associated with a poor prognosis in several tumors. We investigated the phenotype of macrophages in gastric cancer patients with peritoneal carcinomatosis(PC). Intraperitoneal macrophages were found more frequently in PC patients than in Stage I or II patients(control). CD163, an M2 macrophage surface marker, was detected in 71.7% of PC patients and 15.7% of controls. In addition, we examined whether macrophage markers were present in ascites caused by gastric cancer following intraperitoneal paclitaxel. The ratio of M2 macrophages decreased with every therapy. These findings indicate that intraperitoneal M2 macrophages may contribute to the progression of PC, and inhibition of M2 macrophages could be a promising treatment strategy.
authors.affiliation: Dept. of Gastroenterologic Surgery, Kanazawa University.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Sachio
authors.initials: S
authors.lastname: Fushida
authors.forename: Tomoya
authors.initials: T
authors.lastname: Tsukada
authors.forename: Jun
authors.initials: J
authors.lastname: Kinoshita
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Oyama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Okamoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Itasu
authors.initials: I
authors.lastname: Ninomiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujimura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008264:Macrophages / Q000276:immunology*; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000276:immunology* / Q000556:secondary; D010641:Phenotype; D013274:Stomach Neoplasms / Q000276:immunology* / Q000473:pathology