title: Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue.
abstract: Schwannomas and grade I meningiomas are non‑metastatic neoplasms that share the common mutation of gene NF2. They usually appear in neurofibromatosis type 2 patients. Currently, there is no drug treatment available for both tumors, thus the use of wide expression technologies is crucial to identify therapeutic targets. Affymetrix Human Gene 1.0 ST was used to test global gene expression in 22 meningiomas, 31 schwannomas and, as non-tumoral controls, 3 healthy meningeal tissues, 8 non-tumoral nerves and 1 primary Schwann cell culture. A non-stringent P-value cut-off and fold change were used to establish deregulated genes. We identified a subset of genes that were upregulated in meningiomas and schwannomas when compared to their respectively healthy tissues, including PDGFD, CDH1 and SLIT2. Thus, these genes should be thoroughly studied as targets in a possible combined treatment.
authors.affiliation: Molecular Neuro-Oncogenetics Laboratory, Research Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Torres-Martin
authors.affiliation: Department of Otolaryngology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Lassaletta
authors.affiliation: Department of Neurosurgery, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Isla
authors.affiliation: Department of Neurosurgery, Fundacion Jimenez Diaz, Madrid, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: De Campos
authors.affiliation: Genetics and Molecular Biology Laboratory, Federal University of Piau, Parnaiba, Brazil.
authors.forename: Giovanny R
authors.initials: GR
authors.lastname: Pinto
authors.affiliation: Human Cytogenetics Laboratory, Institute of Biological Sciences, Federal University of Para, Belem, Brazil.
authors.forename: Rommel R
authors.initials: RR
authors.lastname: Burbano
authors.affiliation: Department of Biochemistry and Genetics, University of Navarra School of Sciences, Pamplona, Spain.
authors.forename: Javier S
authors.initials: JS
authors.lastname: Castresana
authors.affiliation: Molecular Pathology Research Unit, Virgen de la Salud Hospital, Toledo, Spain.
authors.forename: Barbara
authors.initials: B
authors.lastname: Melendez
authors.affiliation: Molecular Neuro-Oncogenetics Laboratory, Research Unit, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rey
mesh_terms: D015703:Antigens, CD; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D008222:Lymphokines / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008577:Meningeal Neoplasms; D008579:Meningioma / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D009442:Neurilemmoma / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000235:genetics* / Q000378:metabolism; D059467:Transcriptome; D015854:Up-Regulation; D000098552:Slit Homolog 2 Protein
chemical_list: D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D009419:Nerve Tissue Proteins; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; D000098552:Slit Homolog 2 Protein