title: MicroRNA-34 family, mechanisms of action in cancer: a review.
abstract: Altered expression of the microRNA-34 family has been determined to be involved in the pathogenesis of many cancers. In this review, the current knowledge of the cancer-related mechanisms in relation to the modulatory effects of microRNA-34 family were analysed. Expression analysis of the microRNA-34 family has suggested that its members play significant roles in many aspects of cancer biology including proliferation, invasion/metastasis, apoptosis/cell survival, cell cycle/cell growth, migration, senescence/aging, angiogenesis, epigenetic silencing and methylation by regulation of the expression of their target genes. Thus, microRNA-34 family members could act as prognostic markers and therapeutic targets in human cancers.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Maroof
authors.forename: Ali
authors.initials: A
authors.lastname: Salajegheh
authors.forename: Robert Anthony
authors.initials: RA
authors.lastname: Smith
authors.affiliation: Head of Pathology, Griffith Medical School, Gold Coast Campus, Gold Coast QLD 4222, Australia. a.lam@griffith.edu.au.
authors.forename: Alfred King-Yin
authors.initials: AK
authors.lastname: Lam
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002453:Cell Cycle / Q000235:genetics; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D035683:MicroRNAs