title: Reprogramming the tumor stroma: a new paradigm.
abstract: A recent article in Cell shows that vitamin D receptor activation reprograms reactive stroma in the tumor microenvironment to a less inflammatory, quiescent state and is associated with increased drug retention, tumor response, and survival in pancreatic cancer models. Stroma reprogramming, as opposed to ablation, may emerge as a new treatment paradigm.
authors.affiliation: Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: drowley@bcm.edu.
authors.forename: David R
authors.initials: DR
authors.lastname: Rowley
mesh_terms: D065150:Cellular Reprogramming; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D018167:Receptors, Calcitriol / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology*
chemical_list: D018167:Receptors, Calcitriol