title: Protein O-GlcNAcylation and cardiovascular (patho)physiology.
abstract: Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.
authors.affiliation: From the Section of Experimental and Systems Pharmacology, College of Pharmacy, Washington State University, Spokane, Washington 99210-1495 and.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Marsh
authors.affiliation: the Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019.
authors.forename: Helen E
authors.initials: HE
authors.lastname: Collins
authors.affiliation: the Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0019 jchatham@uab.edu.
authors.forename: John C
authors.initials: JC
authors.lastname: Chatham
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D020013:Calcium Signaling; D002319:Cardiovascular System / Q000166:cytology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D044127:Epigenesis, Genetic; D006031:Glycosylation; D006801:Humans; D011506:Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D011506:Proteins; D000117:Acetylglucosamine
keywords: Calcium; Cardiac Hypertrophy; Cardiovascular; Epigenetics; O-Linked N-Acetylglucosamine (O-GlcNAc)