title: Pulmonary vascular changes in asthma and COPD.
abstract: In chronic lung disorders such as in asthma and chronic obstructive pulmonary disease (COPD) there is increased bronchial angiogenesis and remodelling of pulmonary vessels culminating to altered bronchial and pulmonary circulation. The involvement of residential cells such as endothelial cells, smooth muscle cells and pulmonary fibroblasts, all appear to have a crucial role in the progression of vascular inflammation and remodelling. The regulatory abnormalities, growth factors and mediators implicated in the pulmonary vascular changes of asthma and COPD subjects and potential therapeutic targets have been described in this review.
authors.affiliation: Respiratory Cellular and Molecular Biology, Woolcock Institute of Medical Research, The University of Sydney, Sydney, NSW, Australia. Electronic address: louise.harkness@sydney.edu.au.
authors.forename: Louise M
authors.initials: LM
authors.lastname: Harkness
authors.affiliation: Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King's College London, London, United Kingdom. Electronic address: varsha.kanabar@kcl.ac.uk.
authors.forename: Varsha
authors.initials: V
authors.lastname: Kanabar
authors.affiliation: Dept. of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address: h.sharma@vumc.nl.
authors.forename: Hari S
authors.initials: HS
authors.lastname: Sharma
authors.affiliation: Lung Biology, Dept. of Experimental Medical Sciences, Medical Faculty, Lund University, Lund, Sweden. Electronic address: gunilla.westergren-thorsson@med.lu.se.
authors.forename: Gunilla
authors.initials: G
authors.lastname: Westergren-Thorsson
authors.affiliation: Lung Biology, Dept. of Experimental Medical Sciences, Medical Faculty, Lund University, Lund, Sweden. Electronic address: anna-karin.larsson_callerfelt@med.lu.se.
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Larsson-Callerfelt
mesh_terms: D000818:Animals; D001249:Asthma / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008168:Lung / Q000098:blood supply*; D011652:Pulmonary Circulation / Q000502:physiology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology / Q000503:physiopathology*; D066253:Vascular Remodeling / Q000502:physiology
keywords: Airway smooth muscle; Angiogenesis; Asthma; COPD; Pulmonary fibroblast; Vascular endothelial growth factor