title: [Feasibility study for the dexmetomidine utend the drug induced sleep endoscopy].
abstract: OBJECTIVE
  To explore the application of the Dexmedetomidine utend drug induced sleep endoscopy.
  
  
  METHODS
  Forty-four OSAHS patients diagnosed by PSG randomly were divided into group A (Dexmedetomidine group) and group B (Propofol group), each group of 22 cases. Group A: pump the Dexmedetomidine (1 microg/kg) over 15 minutes. Once the patient reached a satisfactory level of sedation, the electronic nasopharyngoscope was introduced into the nasal cavity group B: the propofol (2 mg/kg) was intravenous injected, use the same exmination after the object patients falling asleep. If not, double the injection dose of the two group. Observe and record the patient vital signs, EEG and sleep time, and handle the complications.
  
  
  RESULTS
  The study was successfully completed both in group A and B. Mean arterial pressure (MAP) in group B was lower than group A during the examination significantly (P < 0.05). The time falling to sleep in two groups were (13.4 +/- 2.5) min and (6.6 +/- 1.2) min, and the time in group A was much longer than that in group B. The lowest oxygen saturation during the examination in two groups were 0.835 +/- 0.096 and 0.691 +/- 0.095, and the difference was statistically significant. There was no incidence of adverse reactions in two groups.
  
  
  CONCLUSIONS
  Compared with propofol, Dexmedetomidine is a safer sleep-inducing drug, and it can be used for clinical sleep endoscopy.
authors.forename: Peihua
authors.initials: P
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Ping
authors.initials: P
authors.lastname: Shen
mesh_terms: D000328:Adult; D020927:Dexmedetomidine / Q000627:therapeutic use*; D004724:Endoscopy; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use; D012890:Sleep
chemical_list: D006993:Hypnotics and Sedatives; D020927:Dexmedetomidine; D015742:Propofol