title: Optimal method for early detection of cardiac disorders in thalassemia major patients: magnetic resonance imaging or echocardiography?
abstract: BACKGROUND
  Heart failure resulting from myocardial iron deposition is the most important cause of death in β-thalassemia major (TM) patients. Cardiac T2*magnetic resonance imaging (MRI), echocardiography, and serum ferritin level serve as diagnostic methods for detecting myocardial iron overload. In this study, we aimed to evaluate the relationship between the above-mentioned methods.
  
  
  METHODS
  T2*MRI and echocardiographic measurement of left ventricular (LV) systolic and diastolic function were performed in 63 patients. Serum ferritin level was measured. The relationships between all assessments were evaluated.
  
  
  RESULTS
  There were 40 women and 23 men with a mean age of 23.7±5.1 years (range, 15-35 years). There was no statistically significant correlation between serum ferritin level and LV systolic and diastolic function (P=0.994 and P=0.475, respectively). T2*MRI results had a significant correlation with ferritin level; 63.6% of patients with serum ferritin level >2,000 ng/mL had abnormal cardiac MRI, while none of the patients with ferritin level <1,000 ng/mL had abnormal cardiac MRI (P=0.001). There was no significant correlation between MRI findings and LV systolic function (P=1.00). However, we detected a significant difference between LV diastolic function and cardiac siderosis (P=0.03).
  
  
  CONCLUSIONS
  MRI findings are a good predictor of future cardiac dysfunction, even in asymptomatic TM patients; however, diastolic dysfunction may happen prior to cardiac siderosis in some patients, and echocardiography is able to diagnose this diastolic dysfunction while T2*MRI shows normal findings.
authors.affiliation: Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Farideh
authors.initials: F
authors.lastname: Moussavi
authors.affiliation: Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital, Keshavarz Boulevard, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mounes Aliyari
authors.initials: MA
authors.lastname: Ghasabeh
authors.affiliation: Pediatric cardiology division, Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Shahla
authors.initials: S
authors.lastname: Roodpeyma
authors.affiliation: Department of Pediatric Hematology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Samin
authors.initials: S
authors.lastname: Alavi
authors.affiliation: Advanced Diagnostic and Interventional Radiology Research Center, Imam Khomeini Hospital, Keshavarz Boulevard, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Shakiba
authors.affiliation: Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Riaz
authors.initials: R
authors.lastname: Gheiratmand
authors.affiliation: Department of Pediatric Hematology, Shohada Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Omidghaemi
keywords: Echocardiography; Iron over load; Serum ferritin level; T2*MRI; Thalassemia major