title: Successful treatment of aplastic anaemia associated with HIV infection with eltrombopag: implications for a possible immunomodulatory role.
abstract: We report the first successful treatment with the thrombopoietin receptor mimetic eltrombopag in a patient with severe aplastic anaemia (SAA) associated with HIV infection, thereby avoiding the use of standard immunosuppressive agents for treatment of SAA. Eltrombopag induced a trilineage haematological response. We also show that eltrombopag had an immunomodulatory role with a decrease in proinflammatory T helpers (Th1 and Th17 cells) with increased T-regulatory cell/T-helper ratio, thus contributing to recovery of haemopoiesis.
authors.affiliation: aDepartment of Haematological Medicine, King's College Hospital bKing's College London, London cHIV Medicine Brighton & Sussex University Hospitals NHS Trust, Brighton, UK.
authors.forename: Emily E
authors.initials: EE
authors.lastname: Bart-Smith
authors.forename: Shahram
authors.initials: S
authors.lastname: Kordasti
authors.forename: Austin G
authors.initials: AG
authors.lastname: Kulasekararaj
authors.forename: Daniel
authors.initials: D
authors.lastname: Richardson
authors.forename: Ghulam J
authors.initials: GJ
authors.lastname: Mufti
authors.forename: Judith C W
authors.initials: JC
authors.lastname: Marsh
mesh_terms: D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy*; D001565:Benzoates / Q000008:administration & dosage*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D006834:Hydrazines / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage*; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D001565:Benzoates; D006834:Hydrazines; D007155:Immunologic Factors; D011720:Pyrazoles; C520809:eltrombopag