title: Nocatriones A and B, photoprotective tetracenediones from a marine-derived Nocardiopsis sp.
abstract: Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-5,12-dione (1) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-6,11-dione (2). Ultraviolet B (UVB)-irradiated cells treated with 10 μM nocatrione A (1) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (1) and B (2) may show antiphotoaging activity in UVB-irradiated models.
authors.affiliation: Natural Products Research Center, Korea Institute of Science and Technology (KIST) , Gangneung, Gangwon-do 210-340, Republic of Korea.
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Kim
authors.forename: Eunson
authors.initials: E
authors.lastname: Hwang
authors.forename: Taejung
authors.initials: T
authors.lastname: Kim
authors.forename: Jungyeob
authors.initials: J
authors.lastname: Ham
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Hak Cheol
authors.initials: HC
authors.lastname: Kwon
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000818:Animals; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000382:microbiology*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D011753:Pyrones; D011837:Radiation-Protective Agents; C000593553:nocatrione A; C000593554:nocatrione B