title: Prevalence and Antibiotic Susceptibility Patterns of Extended-Spectrum ß-Lactamase and Metallo-ß-Lactamase-Producing Uropathogenic Escherichia coli Isolates.
abstract: Healthcare professionals worldwide have expressed concern over infections by extended-spectrum ß-lactamase (ESBL) and metallo-ß-lactamase (MBL)-producing bacteria. We evaluated the prevalence of ESBL- and MBL-producing Escherichia coli (E. coli) isolated from community-acquired urinary tract infections (UTIs) and their antibiotic-resistance profiles at 3 private laboratories in Tehran, Iran. E. coli isolates were mostly susceptible to meropenem (90.4%) and imipenem (90.0%), followed by amikacin (89.0%) and gentamicin (84.7%). Moreover, we detected that, of the E. coli isolates, 67 (22.3%) were ESBL producers and 21 (7.0%) of E. coli isolates were MBL positive via the imipenem-ethylenediaminetetraacetic acid (EDTA) combined disc test. This report is the first, to our knowledge, on the prevalence of MBL-producing uropathogenic E. coli (UPEC) strains in Iran. The antibiotic resistance of E. coli isolates revealed that 122 (40.7%) were multidrug resistant. The high number of antibiotic-resistant and ß-lactamase-producing UPEC strains necessitates further attention and consideration, particularly MBL-producing strains.
authors.affiliation: Department of Microbiology, Faculty of Sciences, University of Tehran, Tehran, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Ghadiri
authors.affiliation: Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran h_vaez@resident.mui.ac.ir.
authors.forename: Hamid
authors.initials: H
authors.lastname: Vaez
authors.affiliation: Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Kamal
authors.initials: K
authors.lastname: Razavi-Azarkhiavi
authors.affiliation: Department of Pharmacodynamics and Toxicology, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Rezaee
authors.affiliation: Department of Microbiology, Islamic Azad University, Pharmaceutical Sciences Branch, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Haji-Noormohammadi
authors.affiliation: Department of Biology, Faculty of Sciences, Imam Hosein University, Tehran, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Rahimi
authors.affiliation: Veterinary School, Islamic Azad University, Karaj, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Vaez
authors.affiliation: Department of Pathobiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Enayatollah
authors.initials: E
authors.lastname: Kalantar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology; D056689:Uropathogenic Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases
keywords: E. coli; extended-spectrum ß-lactamase; metallo-ß-lactamase; multidrug-resistant