title: The regulation role of interferon regulatory factor-1 gene and clinical relevance.
abstract: IRF-1, a kind of transcription factors, is expressed constitutively in all cells types except early embryonal cells. By virtue of its interaction with specific DNA sequence, IRF-1 regulates the transcription of a set of target genes which play essential roles in various physiological and pathological processes, including viral infection, tumor immune surveillance, pro-inflammatory injury, development of immunity system. What's more, IRF-1 also interacts with other transcription factors to regulate the specific genes transcription in the nucleus. In immunity system, IRF-1 is suggested to provide a link between innate and adoptive immune system. Although IRF-1 has been demonstrated with essential role in human immunity, the comprehensive understanding of the role of IRF-1 has been restrained because of extensive target genes, Here, we review the clinical relevance of IRF-1 and underlying mechanism based on the latest researches.
authors.affiliation: Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dou
authors.affiliation: Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Liang
authors.affiliation: Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Geller
authors.affiliation: Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Yi-Fa
authors.initials: YF
authors.lastname: Chen
authors.affiliation: Department of Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Chen
mesh_terms: D056704:Adaptive Immunity; D015551:Autoimmunity; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007157:Immunologic Surveillance / Q000235:genetics; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000473:pathology; D050856:Interferon Regulatory Factor-1 / Q000235:genetics* / Q000276:immunology; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015427:Reperfusion Injury / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D015398:Signal Transduction; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: C494257:IRF1 protein, human; D050856:Interferon Regulatory Factor-1
keywords: IRF-1; Immune system; Infection; Injury; Interaction; Oncogenesis