title: Overview of green tea interaction with cardiovascular drugs.
abstract: Sensitive to the massive diffusion of purported metabolic and cardiovascular positive effects of green tea and catechincontaining extracts, many consumers of cardiovascular drugs assume these products as a "natural" and presumably innocuous adjunctive way to increase their overall health. However, green tea may interfere with the oral bioavailability or activity of cardiovascular drugs by various mechanisms, potentially leading to reduced drug efficacy or increased drug toxicity. Available data about interactions between green tea and cardiovascular drugs in humans, updated in this review, are limited so far to warfarin, simvastatin and nadolol, and suggest that the average effects are mild to modest. Nevertheless, in cases of unexpected drug response or intolerance, it is warranted to consider a possible green tea-drug interaction, especially in people who assume large volumes of green tea and/or catechin-enriched products with the conviction that "more-is-better".
authors.forename: José P
authors.initials: JP
authors.lastname: Werba
authors.forename: Shingen
authors.initials: S
authors.lastname: Misaka
authors.forename: Monica G
authors.initials: MG
authors.lastname: Giroli
authors.forename: Shizuo
authors.initials: S
authors.lastname: Yamada
authors.forename: Viviana
authors.initials: V
authors.lastname: Cavalca
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kawabe
authors.forename: Isabella
authors.initials: I
authors.lastname: Squellerio
authors.forename: Federica
authors.initials: F
authors.lastname: Laguzzi
authors.forename: Satomi
authors.initials: S
authors.lastname: Onoue
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Veglia
authors.forename: Veronika
authors.initials: V
authors.lastname: Myasoedova
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Eisuke
authors.initials: E
authors.lastname: Adachi
authors.forename: Naoki
authors.initials: N
authors.lastname: Inui
authors.forename: Elena
authors.initials: E
authors.lastname: Tremoli
authors.affiliation: Centro Cardiologico Monzino, Via C. Parea 4 - 20138 Milan, Italy. pablo.werba@ccfm.it.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D002317:Cardiovascular Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D041743:Herb-Drug Interactions; D006801:Humans; D009248:Nadolol / Q000493:pharmacokinetics; D019821:Simvastatin / Q000493:pharmacokinetics; D013662:Tea / Q000009:adverse effects*; D014859:Warfarin / Q000494:pharmacology
chemical_list: D002317:Cardiovascular Agents; D013662:Tea; D009248:Nadolol; D014859:Warfarin; D019821:Simvastatin