title: Profiling individual human red blood cells using common-path diffraction optical tomography.
abstract: Due to its strong correlation with the pathophysiology of many diseases, information about human red blood cells (RBCs) has a crucial function in hematology. Therefore, measuring and understanding the morphological, chemical, and mechanical properties of individual RBCs is a key to understanding the pathophysiology of a number of diseases in hematology, as well as to opening up new possibilities for diagnosing diseases in their early stages. In this study, we present the simultaneous and quantitative measurement of the morphological, chemical, and mechanical parameters of individual RBCs employing optical holographic microtomography. In addition, it is demonstrated that the correlation analyses of these RBC parameters provide unique information for distinguishing and understanding diseases.
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors.forename: Youngchan
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asan Medical Center, Seoul 138-736, Republic of Korea.
authors.forename: Hyoeun
authors.initials: H
authors.lastname: Shim
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors.forename: Kyoohyun
authors.initials: K
authors.lastname: Kim
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors.forename: HyunJoo
authors.initials: H
authors.lastname: Park
authors.affiliation: Department of Laboratory Medicine, University of Ulsan, College of Medicine and Asan Medical Center, Seoul 138-736, Republic of Korea.
authors.forename: Seongsoo
authors.initials: S
authors.lastname: Jang
authors.affiliation: Department of Physics, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
authors.forename: YongKeun
authors.initials: Y
authors.lastname: Park
mesh_terms: D058948:Cell Tracking; D004912:Erythrocytes / Q000648:ultrastructure*; D006696:Holography; D006801:Humans; D059010:Single-Cell Analysis; D041622:Tomography, Optical