title: Gestational trophoblastic tumours: an update for 2014.
abstract: Gestational trophoblastic disease describes a variety of pregnancy-related diseases including the premalignant conditions of a partial and complete hydatidiform mole and the malignant disorders of invasive mole, choriocarcinoma and the rare placental-site trophoblastic tumour and epithelioid trophoblastic tumour. The availability of a highly sensitive tumour marker in the form of human chorionic gonadotrophin, the chemosensitive character of the disease with effective treatment strategies and centralization of care of a rare group of diseases has resulted in excellent survival rates, which can exceed 98 %. This review gives a general overview of gestational trophoblastic disease, the most recent insights in aetiology and pathology and a summary of the different management strategies.
authors.affiliation: Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust and Imperial College London, Fulham Palace Road, London, W6 8RF, UK.
authors.forename: Fieke E M
authors.initials: FE
authors.lastname: Froeling
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Seckl
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D031901:Gestational Trophoblastic Disease / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D006801:Humans; D011247:Pregnancy; D011379:Prognosis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor