title: Neck dissection in relation with disease-free, disease-specific, and overall survival of patients with squamous cell cancer of the oral cavity.
abstract: OBJECTIVE
  The aims of this study were to assess the accuracy of the presurgical TNM staging of patients with oral squamous cell carcinoma who underwent neck dissection, to explore the relation between the site of the primary tumor and the histopathologically determined neck metastasis, and to perform survival analysis in relation to the histopathologic neck status.
  
  
  METHODS
  A retrospective chart review with prospective follow-up of oral squamous cell carcinoma patients who underwent neck dissection was performed. Presurgical clinical neck status (cN) and postsurgical histopathologic neck status (pN) were recorded. Sensitivity, specificity, and likelihood ratios were calculated. Kaplan-Meier survival analysis was performed.
  
  
  RESULTS
  The patients clinically staged as cN+ have more than 2-fold odds of having a pN+ neck. Those staged as cN0 have 4 times less odds of a pN+ neck. The mean follow-up was 45.8 months. The median overall survival was 27 months (41 mo in the patients with pN0 and 19.5 mo in the patients with pN+). For the patients with pN0, the 1-year overall survival probability was 95%, falling to 90% at 2 years and 81.8% at 5 years. In the patients with pN+, the 1-year overall survival probability was 72.2%, falling to 44.4% at 2 years and 26.7% at 5 years. Disease-specific and disease-free survival exhibited similar trends.
  
  
  CONCLUSIONS
  No means of presurgical assessment either clinical or imaging was sufficiently sensitive and specific enough to predict the metastatic status of the neck. An approximately 50% decrease in the 5-year overall survival rate may be expected when regional metastasis is confirmed.
authors.affiliation: From the *Department of Oral and Maxillofacial Surgery, Theagenio Cancer Hospital; and †Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, and ‡Department of Otolaryngology Head & Neck Surgery, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Georgios
authors.initials: G
authors.lastname: Koloutsos
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Vahtsevanos
authors.forename: Athanassios
authors.initials: A
authors.lastname: Kyrgidis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Kechagias
authors.forename: Stefanos
authors.initials: S
authors.lastname: Triaridis
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Antoniades
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000601:surgery; D037981:Neck Dissection; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D011446:Prospective Studies; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult