title: miR-545 inhibited pancreatic ductal adenocarcinoma growth by targeting RIG-I.
abstract: Pancreatic ductal adenocarcinoma (PDAC) ranks fourth on the list of cancer-related causes of death. Deregulation or dysfunction of miRNAs contribute to cancer development. In this study, we found that low miR-545 level and high RIG-I protein in PDAC tissues were both correlated with low survival rate. MiR-545 up-regulation inhibited PDAC cell lines growth and vice versa. 3'UTR of RIG-I was targeted by miR-545. Thus we concluded that low miR-545 levels in PDAC promote tumor cells growth, and this is associated with reduced survival in PDAC patients. MiR-545 exerts its effects by directly targeting RIG-1.
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Song
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Ji
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Shiwei
authors.initials: S
authors.lastname: Guo
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Anan
authors.initials: A
authors.lastname: Liu
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jing
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
authors.forename: Chenghao
authors.initials: C
authors.lastname: Shao
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Electronic address: li_gang169@163.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.affiliation: Department of Pancreatic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Electronic address: jingangjinggang@126.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Jin
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D001483:Base Sequence; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D011971:Receptors, Immunologic; D016019:Survival Analysis
chemical_list: D020413:3' Untranslated Regions; C000594767:MIR545 microRNA, human; D035683:MicroRNAs; D011971:Receptors, Immunologic; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases
keywords: Cancer growth; Pancreatic ductal adenocarcinoma; Patients survival; RIG-I; miR-545