title: Synthesis, structure, and biological activities of a new μ-oxamido-bridged dicopper(II) complex: the influence of hydrophobicity of bridging ligand on DNA binding and cytotoxic activities.
abstract: A new μ-oxamido-bridged dicopper(II) complex, [Cu2 (papo)(H2 O)- (phen)]Cl·CH3 OH·H2 O, where H3 papo and phen represent N-(2-hydroxyphenyl)-N'-(3-aminopropyl)oxamide and 1,10-phenanthroline, respectively, has been synthesized and characterized by elemental analysis, molar conductivity measurement, infrared and electronic spectra studies, and single-crystal X-ray diffraction. The complex crystallizes in the triclinic space group P-1. Each copper(II) ion is located in a slightly distorted square-pyramidal environment. The Cu···Cu distance through the oxamide bridge is 5.1848(7) Å. The three-dimensional supramolecular structure is built-up by hydrogen bonds and π-π stacking interactions. The dicopper(II) complex exhibits cytotoxic activity against the SMMC-7721 and A549 cell lines. The reactivity toward herring sperm DNA and protein bovine serum albumin (BSA) reveals that the dicopper(II) complex can interact with the DNA by the intercalation mode, and effectively quench the intrinsic fluorescence of BSA via a static mechanism. The influence of hydrophobicity of the bridging ligand on DNA-binding properties and in vitro cytotoxic activities of this kind of dicopper(II) complexes was investigated.
authors.affiliation: Marine Drug & Food Institute, Ocean University of China, 5 Yushan Road, People's Republic of China, Qingdao. yantuanli@ouc.edu.cn.
authors.forename: Ling-Dong
authors.initials: LD
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Tao
authors.forename: Yan-Tuan
authors.initials: YT
authors.lastname: Li
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wu
authors.forename: Cui-Wei
authors.initials: CW
authors.lastname: Yan
mesh_terms: D000818:Animals; D002417:Cattle; D003300:Copper / Q000737:chemistry*; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D012710:Serum Albumin, Bovine / Q000737:chemistry*
chemical_list: D003603:Cytotoxins; D007364:Intercalating Agents; D012710:Serum Albumin, Bovine; D003300:Copper; D004247:DNA
keywords: Crystal Structure; Cytotoxic Activity; DNA- and BSA-Binding; Hydrophobicity; μ-Oxamido-Bridge Dicopper(II) Complex