title: LSF expression and its prognostic implication in colorectal cancer.
abstract: Colorectal cancer (CRC) is the third most common cancer worldwide and the fourth most common cause of cancer death. Therapy failure was the first cause of death. LSF is a transcription factor regulating gene expression of angiogenesis, tumor invasion and proliferation, and is identified as a chemoresistant gene. Real-time PCR and Western blot to analyze mRNA and protein expression of LSF in 23 paired CRC samples. Immunohistochemistry was used to detect protein expression of LSF in 166 paired CRC samples. Both LSF mRNA and protein were upregulated in CRC. High LSF expression in CRC correlated with large tumor size, advanced pN stage, advanced AJCC stage and high Ki-67 index (P < 0.001). High expression of LSF favored worse prognosis. 5-year survival rates of LSF high and low expression were 39.6% and 78.6%, respectively. The 5-year median OS were 34 months and 57 months, respectively. LSF is an important mediator in CRC tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of General Surgery, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of General Surgery, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Du
authors.affiliation: Department of Clinical Pathology, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of Clinical Pathology, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Jin
authors.affiliation: Department of Clinical Pathology, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of Clinical Pathology, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Qi
authors.affiliation: Department of Clinical Pathology, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of Clinical Pathology, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Pu
authors.affiliation: Department of General Surgery, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of Clinical Pathology, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.
authors.forename: Bojian
authors.initials: B
authors.lastname: Fei
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D015153:Blotting, Western; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy; D004268:DNA-Binding Proteins / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D013997:Time Factors; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics; D047368:Tumor Burden; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D019394:Ki-67 Antigen; D012333:RNA, Messenger; C501906:TFCP2 protein, human; D014157:Transcription Factors
keywords: LSF; colorectal cancer; prognosis