title: Bone mineral density in pediatric survivors of Hodgkin and non-Hodgkin lymphomas.
abstract: OBJECTIVE
  To assess skeletal mass in survivors of childhood Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL) 1-5 years after treatment, and to identify potential risk factors influencing bone mineral density (BMD).
  
  
  METHODS
  This cross-sectional study was conducted in a cohort of 43 survivors (HD=31; NHL=12); mean age: 16.21 ± 4.4. Total body bone mineral content (TBMC) and density (TBBMD), and lumbar spine density (LSBMD) were determined using dual-energy X-ray absorptiometry.
  
  
  RESULTS
  Three of all 43 patients developed low BMD. No significant differences in height, weight, and/or BMD Z-scores were found between HD and NHL survivors, children who received and did not receive radiotherapy, and the groups with different chemotherapeutic blocks. No differences were noted between the Z-scores of BMC (mean ± SD: 0.31 ± 1.29 vs. -0.089 ± 0.61, p=0.165), TBBMD (mean ± SD: -0.32 ± 1.21 vs. -0.27 ± 0.91, p=0.76), or the LSBMD (mean ± SD: -0.183 ± 1.54 vs. -0.17 ± 0.87, p=0.637) in subgroups, in accordance with time after therapy (subgroup I<2 years and subgroup II>2 years after treatment). In HD survivors, age at diagnosis only affected the TBBMD Z-score (a decrease of 0.127 in total BMD Z-score per each year, R²=0.999, p<0.001).
  
  
  CONCLUSIONS
  Childhood lymphoma survivors demonstrate no significant deficits in bone mass and tend to maintain their BMD within the normal range when presenting during one to five years' follow-up. However, this specific group requires longitudinal investigation to assess the pattern of peak bone mass achievement and the risk of future bone loss.
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland. Electronic address: kmroslan@umb.edu.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Muszynska-Roslan
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Eryk
authors.initials: E
authors.lastname: Latoch
authors.affiliation: Department of Pediatrics and Developmental Disorders, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Konstantynowicz
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Panasiuk
authors.affiliation: Student's Scientific Society by the Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Stewart
authors.affiliation: Department of Pediatric Oncology and Hematology, Medical University of Bialystok, Bialystok, Poland.
authors.forename: Maryna
authors.initials: M
authors.lastname: Krawczuk-Rybak
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D001862:Bone Resorption / Q000150:complications* / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000150:complications* / Q000628:therapy; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000628:therapy; D008297:Male; D011044:Poland / Q000453:epidemiology; D012307:Risk Factors; D017741:Survivors; D055815:Young Adult
keywords: Bone mineral density; Children; Hodgkin lymphoma; Non-Hodgkin lymphoma; Survivors