title: Brain‑derived neurotrophic factor gene polymorphisms are associated with coronary artery disease‑related depression and antidepressant response.
abstract: Depression is a well‑established risk factor for cardiac morbidity and mortality in patients with coronary artery disease (CAD). Previous studies have demonstrated that the level of brain‑derived neurotrophic factor (BDNF) is decreased in depressed patients and this depletion may be reversed by antidepressants. Several recent studies have suggested that BDNF is involved in the pathogenesis of CAD. The aim of the present study was to investigate the possible association between seven single nucleotide polymorphisms (SNPs) of the BDNF gene (SNPs; rs16917204, rs6265, rs7103873, rs16917237, rs56164415, rs13306221 and rs10767664) and coronary artery disease‑related depression (CAD‑D). In the present study, 616 CAD patients without depression (CAD‑nD) and 155 patients with CAD‑D were recruited, and the response to an eight week sertraline antidepressant treatment regimen was also evaluated. The results demonstrated that a significant association existed between the SNP rs6265, located in exon 4 of the BDNF gene, and CAD‑D [χ2=9.634, P=0.002, odds ratio (OR)=1.486, 95% confidence interval (CI)=1.156‑1.910]. Another potential association was observed for rs13306221 (χ2=5.194, P=0.023, OR=2.139, 95% CI=1.096‑4.175) in the promoter region of the BDNF gene. Strong linkage disequilibrium was observed in block 1 (rs16917204, rs6265; D'>0.9). However, there was no evidence of a significant linkage disequilibrium between the seven SNPs in our sample population. Additionally, carriers of the A allele of rs6265 exhibited improved responses to the sertraline treatment (χ2=8.942, P=0.003, OR=2.136, 95% CI=1.293‑3.528). To the best of our knowledge, these results demonstrate, for the first time, the presence of a significant association between BDNF rs6265 and CAD‑D, the identification of which may facilitate early diagnosis of CAD‑D in the future.
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Guo-Bao
authors.initials: GB
authors.lastname: Su
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Duan
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Wang
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Hai-Mei
authors.initials: HM
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Feng
authors.affiliation: The Third Department of Psychiatry, Henan Mental Health Center, Xinxiang, Henan 453002, P.R. China.
authors.forename: Qing-Xi
authors.initials: QX
authors.lastname: Wang
authors.affiliation: The Third Department of Psychiatry, Henan Mental Health Center, Xinxiang, Henan 453002, P.R. China.
authors.forename: Xu-En
authors.initials: XE
authors.lastname: Liu
authors.affiliation: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan 453100, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D000928:Antidepressive Agents / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D003863:Depression / Q000188:drug therapy* / Q000235:genetics*; D005787:Gene Frequency / Q000187:drug effects / Q000235:genetics; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000187:drug effects / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human