title: The genomic and epigenomic landscapes of AML.
abstract: A progressively better understanding of the genetic and epigenetic abnormalities underlying acute myeloid leukemia has changed clinical practice and affected the outcome of thousands of patients. Over the past decades, approaches focused on cloning, sequencing, and functional characterization of one or a few genes were the preferred (and the only possible) modality of investigation. The advent of disruptive new sequencing technologies brought about an unprecedented acceleration in our learning curve. Our view of the abnormalities required to generate and sustain leukemia is evolving from a piecemeal account based on individual lines of research into a comprehensive view of how all the important components (eg, transcriptional program, chromatin modifications, DNA sequence, alterations in noncoding genome) interact, in each patient and each leukemic cell. In this article, we provide an overall look at this complicated landscape and highlight outstanding issues for future research.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy. Electronic address: piergiuseppe.pelicci@ieo.eu.
authors.forename: Luca
authors.initials: L
authors.lastname: Mazzarella
authors.affiliation: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Riva
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; IFOM, FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
authors.forename: Lucilla
authors.initials: L
authors.lastname: Luzi
authors.affiliation: Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Ronchini
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy; Dipartimento di Scienze della Salute, Università degli Studi di Milano, Milan, Italy. Electronic address: luca.mazzarella@ieo.eu.
authors.forename: Pier Giuseppe
authors.initials: PG
authors.lastname: Pelicci
mesh_terms: D019175:DNA Methylation; D057890:Epigenomics; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D015398:Signal Transduction