title: The 9-bp deletion at position 8272 in region V of mitochondrial DNA is associated with renal cell carcinoma outcome.
abstract: Mitochondrial DNA (mtDNA) is considered a mutation hotspot in various types of tumors, and mitochondrial DNA microsatellite instability (mtMSI) is associated with various cancers. We had previously identified cancer risk-associated MSIs in the D-loop region of mtDNA in renal cell carcinoma (RCC) patients. In the present study, we further investigated the association of MSIs in the non-D-loop region of mtDNA with cancer risk and outcome of RCC. Six microsatellite loci (5892, 8272, 8280, 8281, 8289, 9777) in the non-D-loop of mtDNA were assessed. The CCCCCTCTA at position 8272 was associated with cancer outcome in an overall multivariate analysis (relative risk, 1.599; 95%CI, 1.365-1.872; p < 0.001). mtMSI at position 8272 can therefore be used as an independent prognostic marker for RCC patients.
authors.affiliation: a Departments of Nephrology and.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Bai
authors.affiliation: b Departments of Gastroenterology and Hepatology , The Fourth Hospital of Hebei Medical University , Shijiazhuang , P.R. China.
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
authors.affiliation: a Departments of Nephrology and.
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Xu
authors.affiliation: a Departments of Nephrology and.
authors.forename: Junxia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: a Departments of Nephrology and.
authors.forename: Liwen
authors.initials: L
authors.lastname: Cui
authors.affiliation: a Departments of Nephrology and.
authors.forename: Huiran
authors.initials: H
authors.lastname: Zhang
authors.affiliation: a Departments of Nephrology and.
authors.forename: Shenglei
authors.initials: S
authors.lastname: Zhang
mesh_terms: D020029:Base Pairing; D002292:Carcinoma, Renal Cell / Q000235:genetics*; D004272:DNA, Mitochondrial / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D017384:Sequence Deletion / Q000235:genetics*; D016019:Survival Analysis
chemical_list: D004272:DNA, Mitochondrial
keywords: 8272CCCCCTCTA/del; MSI; mtDNA; outcome; renal cell carcinoma; risk