title: Comparison of the diagnostic accuracies of magnetic resonance elastography and transient elastography for hepatic fibrosis.
abstract: OBJECTIVE
  To compare the diagnostic accuracies of magnetic resonance elastography (MRE) and transient elastography (TE) for hepatic fibrosis.
  
  
  METHODS
  This retrospective study was approved by the institutional review board and included 113 patients (mean age, 63.1±12.2years; 84 men and 29 women) with chronic liver disease who underwent liver biopsy or resection, histopathologic assessment (METAVIR scoring system), and TE within 6months of MRE. Diagnostic accuracies of MRE and TE were compared using receiver operating characteristic curve analysis. Appropriate cutoff values of the two methods determined by maximum positive and minimum negative likelihood ratios were used to calculate the positive and negative predictive values for discriminating significant fibrosis (≥F2) from F0-F1 or cirrhosis (F4) from F0-F3.
  
  
  RESULTS
  Mean (95% confidence interval) area under the receiver operating characteristic curve values of MRE for cirrhosis (F4) (0.97 [0.93-0.99] vs. 0.93 [0.87-0.96]; P=0.0308), clinically significant fibrosis (≥F2) (0.98 [0.94-0.99] vs. 0.87 [0.79-0.92]; P=0.0003), and any fibrosis (≥F1) (0.97 [0.92-0.99] vs. 0.87 [0.76-0.93]; P=0.0126) were significantly higher than those of TE. By using the cutoff values derived from the maximum positive likelihood ratio, the positive and negative predictive values for≥F2 were 98.8% and 83.9%, respectively, by MRE and 98.2% and 44.8%, respectively, by TE; and for F4, 97.0% and 86.3%, respectively, by MRE and 95.8% and 77.5%, respectively, by TE.
  
  
  CONCLUSIONS
  MRE has better diagnostic accuracy than TE for staging hepatic fibrosis.
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan. Electronic address: si99006@yahoo.co.jp.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Ichikawa
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan; Department of Radiology, University of Wisconsin, Madison, WI, USA. Electronic address: umotosugi@uwhealth.org.
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan. Electronic address: morisakahiroyuki@hotmail.co.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morisaka
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan. Electronic address: snkthr@yahoo.co.jp.
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Sano
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan. Electronic address: ichikawa@yamanashi.ac.jp.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
authors.affiliation: First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan. Electronic address: tatsumi@yamanashi.ac.jp.
authors.forename: Akihisa
authors.initials: A
authors.lastname: Tatsumi
authors.affiliation: First Department of Internal Medicine, University of Yamanashi, Yamanashi, Japan. Electronic address: enomoto@yamanashi.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Enomoto
authors.affiliation: First Department of Surgery, University of Yamanashi, Yamanashi, Japan. Electronic address: masam@yamanashi.ac.jp.
authors.forename: Masanori
authors.initials: M
authors.lastname: Matsuda
authors.affiliation: First Department of Surgery, University of Yamanashi, Yamanashi, Japan. Electronic address: hfujii@yamanashi.ac.jp.
authors.forename: Hideki
authors.initials: H
authors.lastname: Fujii
authors.affiliation: Department of Radiology, University of Yamanashi, Yamanashi, Japan. Electronic address: honishi1829@gmail.com.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Onishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D054459:Elasticity Imaging Techniques; D005260:Female; D005355:Fibrosis / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Hepatic fibrosis; Liver stiffness; Magnetic resonance elastography; Transient elastography