title: Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage.
abstract: Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1, 2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.
authors.affiliation: General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
authors.forename: Sumeng
authors.initials: S
authors.lastname: Liu
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.
authors.forename: Wu
authors.initials: W
authors.lastname: Liu
authors.affiliation: General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Ma
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.
authors.forename: Kegao
authors.initials: K
authors.lastname: Liu
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.
authors.forename: Meizi
authors.initials: M
authors.lastname: Wang
keywords: electroretinography; ketorolac tromethamine; neural regeneration; nonsteroidal anti-inflammatory drug; pharmacology; regeneration; retina; retinal toxicity; segment disease; suprachoroidal space