title: Combined benefit of prediction and treatment: a criterion for evaluating clinical prediction models.
abstract: Clinical treatment decisions rely on prognostic evaluation of a patient's future health outcomes. Thus, predictive models under different treatment options are key factors for making good decisions. While many criteria exist for judging the statistical quality of a prediction model, few are available to measure its clinical utility. As a consequence, we may find that the addition of a clinical covariate or biomarker improves the statistical quality of the model, but has little effect on its clinical usefulness. We focus on the setting where a treatment decision may reduce a patient's risk of a poor outcome, but also comes at a cost; this may be monetary, inconvenience, or the potential side effects. This setting is exemplified by cancer chemoprevention, or the use of statins to reduce the risk of cardiovascular disease. We propose a novel approach to assessing a prediction model using a formal decision analytic framework. We combine the predictive model's ability to discriminate good from poor outcome with the net benefit afforded by treatment. In this framework, reduced risk is balanced against the cost of treatment. The relative cost-benefit of treatment provides a useful index to assist patient decisions. This index also identifies the relevant clinical risk regions where predictive improvement is needed. Our approach is illustrated using data from a colorectal adenoma chemoprevention trial.
authors.affiliation: Agricultural and Biosystems Engineering, College of Agriculture and Life Sciences, Tucson, AZ. ; The BIO5 Institute, The University of Arizona, Tucson, AZ.
authors.forename: Dean
authors.initials: D
authors.lastname: Billheimer
authors.affiliation: Cancer Prevention Pharmaceuticals, Tucson, AZ.
authors.forename: Eugene W
authors.initials: EW
authors.lastname: Gerner
authors.affiliation: Department of Epidemiology and Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA.
authors.forename: Christine E
authors.initials: CE
authors.lastname: McLaren
authors.affiliation: Ventana Medical Systems, Tucson, AZ.
authors.forename: Bonnie
authors.initials: B
authors.lastname: LaFleur
keywords: chemoprevention; decision analysis; model evaluation; predictive modeling