title: Evaluation of the antimalarial potential of Icacina senegalensis Juss (Icacinaceae).
abstract: OBJECTIVE
  To evaluate in vivo antimalarial activity of methanol leaf extract of Icacina senegalensis.
  
  
  METHODS
  The extract was investigated for activity against early and established malaria infections using Swiss albino mice infected with Plasmodium berghei at dose levels of 25, 50 and 100 mg/kg. Chloroquine (10 mg/kg) was used as positive control.
  
  
  RESULTS
  A dose dependent chemo-suppression of the parasites was observed at different dose levels of the extract tested with a considerable mean survival time.
  
  
  CONCLUSIONS
  The results support further investigation on components of traditional medicines as potential new antimalarial agents.
authors.affiliation: Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria. Electronic address: drdavidoku@yahoo.co.uk.
authors.forename: Essien
authors.initials: E
authors.lastname: David-Oku
authors.affiliation: Department of Biochemistry, College of Medical Sciences, University of Calabar, Nigeria.
authors.forename: Obiajunwa-Otteh Juliet
authors.initials: OO
authors.lastname: Ifeoma
authors.affiliation: Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
authors.forename: Akuodor Godwin
authors.initials: AG
authors.lastname: Christian
authors.affiliation: Department of Pharmacology, College of Medical Sciences, University of Calabar, Nigeria.
authors.forename: Essien Augustine
authors.initials: EA
authors.lastname: Dick
keywords: Antimalarial agent; Herbal medicine; Icacina senegalensis; Leaf; Mice