title: Synthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile.
abstract: Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including α,β,γ,δ-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.
authors.affiliation: Department of Chemistry and Center for Cancer Research, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA. mjdai@purdue.edu.
authors.forename: Wandi
authors.initials: W
authors.lastname: Zhang
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Haskins
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Mingji
authors.initials: M
authors.lastname: Dai
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D000577:Amides; D009570:Nitriles; D014867:Water; D010165:Palladium; C032159:acetonitrile