title: Association of PTH and carotid thickness in patients with chronic kidney failure and secondary hyperparathyroidism.
abstract: BACKGROUND
  Cardiovascular diseases (CVDs) are the leading cause of death in terminal patients with chronic kidney failure (CKF). Diverse risk factors are involved in the pathogenesis, and are classified as traditional, which affect the general population; and non-traditional, which are peculiar to patients with CKF. Secondary hyperparathyroidism, a non-traditional and common factor in CKF, can cause an increased rate of bone absorption with mobilization of calcium and phosphorus. If the product of calcium x phosphorus is increased, the solubility of this ionic pair may be exceeded and deposition of calcium phosphate in cardiac and vascular tissues occur (called metastatic calcification).
  
  
  OBJECTIVE
  To verify eventual relationship between the thickness of the common carotid artery and the levels of PTH in patients with CKF.
  
  
  METHODS
  Evaluations by Doppler ultrasonography were performed to measure the width of the carotid artery wall and to search for possible correlations between different values of PTH serum levels, mineral disturbances and traditional risk factors in the carotid changes found in individuals with dialytic CKF and secondary hyperparathyroidism.
  
  
  RESULTS
  Differences in the cholesterol level and age were observed in patients with signals of arterial calcification. A significant relationship was also observed between the PTH serum levels and the carotid artery wall thickness (r = 0.31, p = 0.03).
  
  
  CONCLUSIONS
  Data from this study show the possible concomitance of traditional factors and factors related to CKF in the genesis of CVDs in uremia.
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas.
authors.forename: André Falcão Pedrosa
authors.initials: AF
authors.lastname: Costa
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas.
authors.forename: Felipe
authors.initials: F
authors.lastname: Barufaldi
authors.affiliation: Universidade Estadual de Ciências da Saúde de Alagoas.
authors.forename: Marcelo Augusto Duarte
authors.initials: MA
authors.lastname: Silveira
authors.affiliation: Hospital das Forças Armadas, Universidade Católica de Brasília.
authors.forename: Vitorino Modesto
authors.initials: VM
authors.lastname: dos Santos
authors.affiliation: Fundação de Amparo à Pesquisa do Estado de Alagoas.
authors.forename: Pedro de Lemos
authors.initials: Pde L
authors.lastname: Menezes
mesh_terms: D000328:Adult; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000097:blood* / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D010281:Parathyroid Hormone