title: [The effect of immunotherapy and hyperthermia on patients with advanced or recurrent cancer - analyses by cancer type and recurrence form].
abstract: We treated 1,939 patients with advanced or recurrent cancer using hyperthermia and or immunotherapy between July 2005 and November 2013. Standard therapy showed no effect or was refused by these patients. There were 309(15.9%)patients who experienced a clinical benefit(complete response[CR], partial response[PR], and long-term stable disease[SD], >6 months), including 52 CR cases. The effective rate of immunotherapy increased from 9.9%to 19.1%using hyperthermia. The effective rate for patients with hyperthermia-alone was 3.6%, and skin and regional lymph node metastases disappeared. Immunotherapy alone was effective for liver or lung metastases. Combined hyperthermia and immunotherapy had a beneficial effect on multiple metastases observed in important plural solid organs. Ovarian cancer had the highest effective rate (25.0%), followed by prostate cancer.
authors.affiliation: Osaka Cancer Immuno-Chemotherapy Center.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
authors.forename: Kana
authors.initials: K
authors.lastname: Nakamura
authors.forename: Mitsuyuki
authors.initials: M
authors.lastname: Sato
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Tomimaru
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takeda
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D007167:Immunotherapy; D009367:Neoplasm Staging; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D012008:Recurrence