title: Think inside the BOCs: a mechanism underlying medulloblastoma progression.
abstract: Approximately one-third of medulloblastoma cases are associated with genetic lesions of Hedgehog (Hh) signaling pathway components. In this issue of Developmental Cell, Mille et al. (2014) show that the Hh coreceptor Boc functions specifically in the progression of early- to advanced-stage medulloblastoma by promoting Cyclin D1-dependent DNA damage and genomic instability.
authors.affiliation: Center for Tumor Biology and Immunology, Institute of Molecular Biology and Tumor Research (IMT), Philipps University, Hans-Meerwein-Str. 3, 35043 Marburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Lauth
authors.affiliation: Department of Biosciences and Nutrition, Center for Innovative Medicine, Karolinska Institutet, Novum, SE-14183 Huddinge, Sweden. Electronic address: rune.toftgard@ki.se.
authors.forename: Rune
authors.initials: R
authors.lastname: Toftgard
mesh_terms: D000818:Animals; D002528:Cerebellar Neoplasms / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism*; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008527:Medulloblastoma / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: C510745:Boc protein, mouse; D053823:Hedgehog Proteins; D007074:Immunoglobulin G; D011956:Receptors, Cell Surface; C465570:Shh protein, mouse