title: [Recurrent early pregnancy loss: What the life-birth chances are? A 10-years retrospective study].
abstract: OBJECTIVE
  Recurrent miscarriages are a current consultation pattern. Etiologic evaluation is classically proposed and preventive therapy should be discussed. We wanted to study our University Hospital pregnancies outcomes, following 3 repetitive early miscarriages, and how those patients are managed.
  
  
  METHODS
  A 10-years retrospective study has been performed in our center, with 296 patients found having a three-repetitive miscarriage experience. Information about diagnostic evaluation following miscarriages, preventive therapy initiation, and next pregnancy outcome has been provided.
  
  
  RESULTS
  Around 62.5% of the patients experienced a life-birth. When investigations were done (n=148), a 64.9% part of the patients had abnormal results. Life-birth rate was more important when there were normal karyotypes or no thrombophilia found (respectively p equal 0.30 and 0.45). We noticed a better prognostic in the group of patients with normal investigations results who had a preventive therapy (n=20, 85% of life-birth, P=0.19).
  
  
  CONCLUSIONS
  When done, investigations for recurrent miscarriages, allow the finding of an abnormality in two thirds of cases. Wonderingly, outcomes are very encouraging since that almost two thirds of the patients experienced life-birth. Investigations indications, results interpretations, and consecutive therapy should be well thought but preventive therapy seems to be efficient in the normal results patient group.
authors.affiliation: Service d'aide médicale à la procréation, centre médico-chirurgical et obstétrical, BP 120, 19, rue Louis-Pasteur, 67303 Schiltigheim, France. Electronic address: stephaniebonne@hotmail.fr.
authors.forename: S
authors.initials: S
authors.lastname: Bonne
authors.affiliation: Service d'aide médicale à la procréation, centre médico-chirurgical et obstétrical, BP 120, 19, rue Louis-Pasteur, 67303 Schiltigheim, France.
authors.forename: N
authors.initials: N
authors.lastname: Sananes
authors.affiliation: Service d'aide médicale à la procréation, centre médico-chirurgical et obstétrical, BP 120, 19, rue Louis-Pasteur, 67303 Schiltigheim, France.
authors.forename: C
authors.initials: C
authors.lastname: Rongières
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy*; D000328:Adult; D001723:Birth Rate; D003937:Diagnosis, Differential; D020964:Embryo Loss / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology
keywords: Bilan; Fausses couches répétées; Investigation; Issues de grossesses; Pregnancies outcomes; Preventive therapy; Recurrent miscarriage; Traitement préventif