title: Intramedullary spinal cord metastasis from pancreatic neuroendocrine tumor.
abstract: Intramedullary spinal cord metastasis (ISCM) is very rare and its optimal treatment remains controversial. Pancreatic neuroendocrine tumor (pNET) is a rare tumor that usually presents with hepatic metastasis. Hepatic failure due to tumor progression is the major cause of death in cases of pNET. To date, no report has described a case of ISCM from pNET. Although spinal cord metastasis of a solid tumor is uncommon, it is a critical condition that can cause a potentially irreversible loss of neurologic function. Here, we report the case of a 45-year-old man who presented with leg weakness and voiding difficulty, and was found to have ISCM from pNET. Surgical treatment prevented further neurological deterioration. This is the first case report of ISCM from pNET.
authors.affiliation: Jung Ho Kim, Department of Internal Medicine, Gachon University Gil Medical Center, Namdong-gu 405-760, South Korea.
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Jung Ho Kim, Department of Internal Medicine, Gachon University Gil Medical Center, Namdong-gu 405-760, South Korea.
authors.forename: Chang Lim
authors.initials: CL
authors.lastname: Hyun
authors.affiliation: Jung Ho Kim, Department of Internal Medicine, Gachon University Gil Medical Center, Namdong-gu 405-760, South Korea.
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D018358:Neuroendocrine Tumors / Q000737:chemistry / Q000150:complications / Q000556:secondary* / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology*; D013120:Spinal Cord Neoplasms / Q000737:chemistry / Q000150:complications / Q000556:secondary* / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome; D014555:Urination Disorders / Q000209:etiology / Q000503:physiopathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Intramedullary; Metastasis; Neuroendocrine tumor; Pancreas; Spinal cord neoplasm