title: Metabolic syndrome in Spanish patients with psoriasis needing systemic therapy: Prevalence and association with cardiovascular disease in PSO-RISK, a cross-sectional study.
abstract: BACKGROUND
  Increasing evidence indicates a relationship between psoriasis and metabolic syndrome (MS). We evaluated the prevalence of MS in patients receiving systemic treatment for psoriasis in Spain, and its relationship to cardiovascular disease (CVD).
  
  
  METHODS
  This cross-sectional, multicenter, non-interventional study enrolled 368 patients with moderate-to-severe psoriasis requiring systemic treatment. Clinical parameters for psoriasis, CV risk factors, MS and CVD were assessed. Descriptive and logistic regression analyses were performed.
  
  
  RESULTS
  352 patients were included (median psoriasis duration: 18 years, plaque psoriasis [95.7%], psoriatic arthritis [22.8%]). Overall, 132 patients (37.5%) fulfilled diagnostic criteria for MS; the most prevalent MS components were high blood pressure and increased waist circumference. Patients with MS were older, more likely to be obese and to have a sedentary lifestyle and hypercholesterolemia than those without MS. CVD was more prevalent in patients with MS than in those without (29.5% versus 15.9%, p = 0.002), particularly coronary heart disease (CHD), myocardial infarction and heart failure. MS was independently associated with CVD (OR 1.98, p = 0.018) and CHD (OR 2.02, p = 0.044).
  
  
  CONCLUSIONS
  The prevalence of MS was high among patients with moderate-to-severe psoriasis requiring systemic treatment, and was associated with a higher prevalence of CVD. Dermatologists should consider implementing simple screening protocols.
authors.affiliation: Departmento de Dermatología, Hospital General Universitario de Alicante , Alicante , Spain .
authors.forename: I
authors.initials: I
authors.lastname: Belinchón
authors.forename: F
authors.initials: F
authors.lastname: Vanaclocha
authors.forename: P
authors.initials: P
authors.lastname: de la Cueva-Dobao
authors.forename: P
authors.initials: P
authors.lastname: Coto-Segura
authors.forename: J
authors.initials: J
authors.lastname: Labandeira
authors.forename: P
authors.initials: P
authors.lastname: Herranz
authors.forename: R
authors.initials: R
authors.lastname: Taberner
authors.forename: B
authors.initials: B
authors.lastname: Juliá
authors.forename: L
authors.initials: L
authors.lastname: Cea-Calvo
authors.forename: L
authors.initials: L
authors.lastname: Puig
mesh_terms: D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D015995:Prevalence; D011565:Psoriasis / Q000188:drug therapy*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology
keywords: Cardiovascular disease; metabolic syndrome; prevalence; psoriasis