title: Interferon-induced guanylate-binding proteins promote cytosolic lipopolysaccharide detection by caspase-11.
abstract: Lipopolysaccharide (LPS) from gram-negative bacteria is a classical pathogen-associated molecular pattern and a strong inducer of immune responses. While the detection of LPS on the cell surface and in the endosome by Toll-like receptor 4 (TLR4) has been studied for some time, it has only recently been discovered that LPS can also be sensed in the cytosol of cells by a noncanonical inflammasome pathway, resulting in the activation of the cysteine protease caspase-11. Intriguingly, activation of this pathway requires the production of interferons (IFNs) and the induction of a class of IFN-induced GTPases called guanylate-binding proteins (GBPs), which have previously been linked to cell-autonomous killing of intracellular microbes. In this study, we review the recent advances in our understanding of cytosolic LPS sensing and the function of mammalian GBPs.
authors.affiliation: Focal Area Infection Biology, Biozentrum, University of Basel , Basel, Switzerland .
authors.forename: Etienne
authors.initials: E
authors.lastname: Meunier
authors.forename: Petr
authors.initials: P
authors.lastname: Broz
mesh_terms: D000818:Animals; D020169:Caspases / Q000502:physiology*; D053471:Caspases, Initiator; D003593:Cytoplasm / Q000201:enzymology / Q000276:immunology; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000502:physiology; D007372:Interferons / Q000502:physiology*; D008070:Lipopolysaccharides / Q000494:pharmacology*
chemical_list: D058847:Inflammasomes; D008070:Lipopolysaccharides; D007372:Interferons; C101136:Casp4 protein, mouse; D020169:Caspases; D053471:Caspases, Initiator; D019204:GTP-Binding Proteins