title: Head muscle development.
abstract: The developmental paths that lead to the formation of skeletal muscles in the head are distinct from those operating in the trunk. Craniofacial muscles are associated with head and neck structures. In the embryo, these structures derive from distinct mesoderm populations. Distinct genetic programs regulate different groups of muscles within the head to generate diverse muscle specifications. Developmental and lineage studies in vertebrates and invertebrates demonstrated an overlap in progenitor populations derived from the pharyngeal mesoderm that contribute to certain head muscles and the heart. These studies reveal that the genetic program controlling pharyngeal muscles overlaps with that of the heart. Indeed cardiac and craniofacial birth defects are often linked. Recent studies suggest that early chordates, the last common ancestor of tunicates and vertebrates, had an ancestral pharyngeal mesoderm lineage that later during evolution gave rise to both heart and craniofacial structures. This chapter summarizes studies related to the origins, signaling, genetics, and evolution of the head musculature, highlighting its heterogeneous characteristics in all these aspects.
authors.affiliation: Department of Biological Regulation, Weizmann Institute of Science, Rehovot, 76100, Israel, eldad.tzahor@weizmann.ac.il.
authors.forename: Eldad
authors.initials: E
authors.lastname: Tzahor
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics; D019070:Cell Lineage; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000254:growth & development*; D008648:Mesoderm / Q000254:growth & development; D024510:Muscle Development / Q000235:genetics*; D018482:Muscle, Skeletal / Q000254:growth & development*; D009432:Neural Crest / Q000254:growth & development; D014714:Vertebrates / Q000235:genetics / Q000254:growth & development*