title: Therapeutic effect of carotid artery stenting versus endarterectomy for patients with high-risk carotid stenosis.
abstract: OBJECTIVE
  To investigate therapeutic effect of carotid artery stenting versus endarterectomy for patients with high-risk carotid stenosis.
  
  
  METHODS
  A total of 130 carotid stenosis patients at high-risk of stroke were randomly divided into stenting group and endarterectomy group, including 65 patients in each group. The patients in the endarterectomy group underwent endarterectomy and those in the stenting group received carotid artery stenting for treatment.
  
  
  RESULTS
  After operation, carotid intima-media thickness (IMT), plague areas and carotid artery resistance indexes in both groups decreased significantly, and the carotid artery peak blood flow velocities increased significantly and had significant differences with that before operation (P < 0.05). After operation, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) values in two groups all significantly decreased, and intragroup and intergroup differences were statistically significant (P < 0.05). Postoperative three months of followed-up found that the mortality rate in stenting group was 1.5% and that in the endarterectomy group was 9.2%; the mortality rate in the stenting group was significantly lower than the endarterectomy group (P < 0.05).
  
  
  CONCLUSIONS
  Compared with carotid endarterectomy, application of carotid artery stenting can effectively promote patency of blood flow in the carotid artery, and exertion of its effect is related to lowering lipid and lowering inflammatory factor expression.
authors.affiliation: Department of Neurology, Jiangmen Central Hospital Jiangmen 529070, China.
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Li
authors.affiliation: Department of Neurology, Jiangmen Central Hospital Jiangmen 529070, China.
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Zhong
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Jinan University Shenzhen 518020, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Jinan University Shenzhen 518020, China.
authors.forename: Qi-Zhang
authors.initials: QZ
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Jinan University Shenzhen 518020, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Guo
keywords: Carotid stenosis; blood lipids; endarterectomy; inflammatory factor; resistance index; vascular stenting