title: A non-resonant mass sensor to eliminate the "missing mass" effect during mass measurement of biological materials.
abstract: Resonant sensors and crystal oscillators for mass detection need to be excited at very high natural frequencies (MHz). Use of such systems to measure mass of biological materials affects the accuracy of mass measurement due to their viscous and/or viscoelastic properties. The measurement limitation of such sensor system is the difficulty in accounting for the "missing mass" of the biological specimen in question. A sensor system has been developed in this work, to be operated in the stiffness controlled region at very low frequencies as compared to its fundamental natural frequency. The resulting reduction in the sensitivity due to non-resonant mode of operation of this sensor is compensated by the high resolution of the sensor. The mass of different aged drosophila melanogaster (fruit fly) is measured. The difference in its mass measurement during resonant mode of operation is also presented. That, viscosity effects do not affect the working of this non-resonant mass sensor is clearly established by direct comparison.
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Science, Bangalore 560012, India.
authors.forename: V
authors.initials: V
authors.lastname: Shrikanth
authors.affiliation: Department of Mechanical Engineering, Indian Institute of Science, Bangalore 560012, India.
authors.forename: M S
authors.initials: MS
authors.lastname: Bobji
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000737:chemistry; D055615:Electrical Equipment and Supplies; D004867:Equipment Design; D007814:Larva / Q000737:chemistry; D008962:Models, Theoretical; D008970:Molecular Weight; D010063:Ovum / Q000737:chemistry; D014783:Viscosity