title: Incidence, serum IgE and TARC/CCL17 levels in atopic dermatitis associated with other allergic diseases: an update from the Ishigaki cohort.
abstract: Population cohort studies are important for understanding the current status of the target disease and its relation to comorbidity, gender, age, or environmental factors. To better understand atopic dermatitis (AD) and its related diseases, we initiated in 2001 a population cohort study of nursery school children from Ishigaki Island, Okinawa, Japan. The cohort study comprised a dermatologist-based physical examination, questionnaire administration, and blood sample analysis. The mean prevalence of AD was 6.3%. Questionnaire-based bronchial asthma and egg allergy in the children and paternal and sibling AD were statistically significant risk factors for AD. Boys with AD had a high incidence of asthma that was coexistent with a high serum total immunoglobulin E level. Also a high incidence of egg allergy was associated with greater AD severity as assessed by TARC/CCL17.
authors.affiliation: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. takeuchs@dermatol.med.kyushu-u.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Hitokazu
authors.initials: H
authors.lastname: Esaki
authors.forename: Norihiro
authors.initials: N
authors.lastname: Furusyo
authors.forename: Sayaka
authors.initials: S
authors.lastname: Hayashida
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamura
authors.forename: Gaku
authors.initials: G
authors.lastname: Tsuji
authors.forename: Masaki
authors.initials: M
authors.lastname: Takemura
authors.forename: Jun
authors.initials: J
authors.lastname: Hayashi
authors.forename: Masutaka
authors.initials: M
authors.lastname: Furue
mesh_terms: D044466:Asian People; D001249:Asthma / Q000453:epidemiology; D054414:Chemokine CCL17 / Q000097:blood*; D002675:Child, Preschool; D015331:Cohort Studies; D003876:Dermatitis, Atopic / Q000097:blood / Q000453:epidemiology*; D021181:Egg Hypersensitivity / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D065631:Rhinitis, Allergic / Q000453:epidemiology; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: C106230:CCL17 protein, human; D054414:Chemokine CCL17; D007073:Immunoglobulin E