title: The outcome at ten years of lateral closing-wedge high tibial osteotomy: determinants of survival and functional outcome.
abstract: The aim of this study was to examine the functional outcome at ten years following lateral closing wedge high tibial osteotomy for medial compartment osteoarthritis of the knee and to define pre-operative predictors of survival and determinants of functional outcome. 164 consecutive patients underwent high tibial osteotomy between 2000 and 2002. A total of 100 patients (100 knees) met the inclusion criteria and 95 were available for review at ten years. Data were collected prospectively and included patient demographics, surgical details, long leg alignment radiographs, Western Ontario and McMaster Universities osteoarthritis index (WOMAC) and Knee Society scores (KSS) pre-operatively and at five and ten years follow-up. At ten years, 21 patients had been revised at a mean of five years. Overall Kaplan-Meier survival was 87% (95% confidence interval (CI) 81 to 94) and 79% (95% CI 71 to 87) at five and ten years, respectively. When compared with unrevised patients, those who had been revised had significantly lower mean pre-operative WOMAC Scores (47 (21 to 85) vs 65 (32 to 99), p < 0.001), higher mean age (54 yrs (42 to 61) vs 49 yrs (26 to 66), p = 0.006) and a higher mean BMI (30.2; 25 to 39 vs 27.9; 21 to 36, p = 0.005). Each were found to be risk factors for revision, with hazard ratios of 10.7 (95% CI 4 to 28.6; pre-operative WOMAC < 45), 6.5 (95% CI 2.4 to 17.7; age > 55) and 3.0 (95%CI 1.2 to 7.6; BMI > 30). Survival of patients with pre-operative WOMAC > 45, age < 55 and BMI < 30 was 97% at five and ten years. WOMAC and KSS in surviving patients improved significantly between pre-operative (mean 61; 32 to 99) and five (mean 88; 35 to 100, p = 0.001) and ten years (mean 84; 38 to 100, p = 0.001). Older patients had better functional outcomes overall, despite their higher revision rate. This study has shown that improved survival is associated with age < 55 years, pre-operative WOMAC scores > 45 and, a BMI < 30. In patients over 55 years of age with adequate pre-operative functional scores, survival can be good and functional outcomes can be significantly better than their younger counterparts. We recommend the routine use of pre-operative functional outcome scores to guide decision-making when considering suitability for high tibial osteotomy.
authors.affiliation: North Sydney Orthopaedic and Sports Medicine Centre, Sydney, Australia.
authors.forename: N R
authors.initials: NR
authors.lastname: Howells
authors.affiliation: North Sydney Orthopaedic and Sports Medicine Centre, Sydney, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Salmon
authors.affiliation: North Sydney Orthopaedic and Sports Medicine Centre, Sydney, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Waller
authors.affiliation: North Sydney Orthopaedic and Sports Medicine Centre, Sydney, Australia.
authors.forename: J
authors.initials: J
authors.lastname: Scanelli
authors.affiliation: North Sydney Orthopaedic and Sports Medicine Centre, Sydney, Australia.
authors.forename: L A
authors.initials: LA
authors.lastname: Pinczewski
mesh_terms: D000328:Adult; D000368:Aged; D003161:Compartment Syndromes / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D016001:Confidence Intervals; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D009517:New South Wales / Q000453:epidemiology; D020370:Osteoarthritis, Knee / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D010027:Osteotomy / Q000379:methods*; D011184:Postoperative Period; D016059:Range of Motion, Articular / Q000502:physiology*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013977:Tibia / Q000601:surgery*; D016896:Treatment Outcome
keywords: High tibial osteotomy; Knee; Lateral closing wedge; Medial compartment osteoarthritis