title: Nuclear actin activates human transcription factor genes including the OCT4 gene.
abstract: RNA microarray analyses revealed that nuclear actin activated many human transcription factor genes including OCT4, which is required for gene reprogramming. Oct4 is known to be activated by nuclear actin in Xenopus oocytes. Our findings imply that this process of OCT4 activation is conserved in vertebrates and among cell types and could be used for gene reprogramming of human cells.
authors.affiliation: a Laboratory of Molecular Biology, Graduate School of Agricultural Science , Tohoku University , Sendai , Japan.
authors.forename: Shota
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Makio
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sakata-Sogawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Harata
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D050814:Octamer Transcription Factor-3 / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D014158:Transcription, Genetic / Q000235:genetics; D015533:Transcriptional Activation
chemical_list: D000199:Actins; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human
keywords: OCT4; nuclear actin; transcription; transcription microarray