title: Treatment of gastric varices with partial splenic embolization in a patient with portal vein thrombosis and a myeloproliferative disorder.
abstract: Therapeutic options for gastric variceal bleeding in the presence of extensive portal vein thrombosis associated with a myeloproliferative disorder are limited. We report a case of a young woman who presented with gastric variceal bleeding secondary to extensive splanchnic venous thrombosis due to a Janus kinase 2 mutation associated myeloproliferative disorder that was managed effectively with partial splenic embolization.
authors.affiliation: Robert Gianotti, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Robert
authors.initials: R
authors.lastname: Gianotti
authors.affiliation: Robert Gianotti, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Hearns
authors.initials: H
authors.lastname: Charles
authors.affiliation: Robert Gianotti, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hymes
authors.affiliation: Robert Gianotti, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Hersh
authors.initials: H
authors.lastname: Chandarana
authors.affiliation: Robert Gianotti, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Samuel
authors.initials: S
authors.lastname: Sigal
mesh_terms: D000328:Adult; D004621:Embolization, Therapeutic / Q000379:methods*; D004932:Esophageal and Gastric Varices / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D053614:Janus Kinase 2 / Q000235:genetics; D008279:Magnetic Resonance Imaging; D009154:Mutation; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000175:diagnosis / Q000201:enzymology / Q000235:genetics / Q000628:therapy; D011169:Portal Vein; D013157:Splenic Artery; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
chemical_list: C507924:JAK2 protein, human; D053614:Janus Kinase 2
keywords: Gastric varices; Janus kinase 2, Portal hypertension; Myeloproliferative disorder; Partial splenic embolization; Portal vein thrombosis