title: Damage of hippocampal neurons in rats with chronic alcoholism.
abstract: Chronic alcoholism can damage the cytoskeleton and aggravate neurological deficits. However, the effect of chronic alcoholism on hippocampal neurons remains unclear. In this study, a model of chronic alcoholism was established in rats that were fed with 6% alcohol for 42 days. Endogenous hydrogen sulfide content and cystathionine-beta-synthase activity in the hippocampus of rats with chronic alcoholism were significantly increased, while F-actin expression was decreased. Hippocampal neurons in rats with chronic alcoholism appeared to have a fuzzy nuclear membrane, mitochondrial edema, and ruptured mitochondrial crista. These findings suggest that chronic alcoholism can cause learning and memory decline in rats, which may be associated with the hydrogen sulfide/cystathionine-beta-synthase system, mitochondrial damage and reduced expression of F-actin.
authors.affiliation: Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China ; Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Ailin
authors.initials: A
authors.lastname: Du
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China ; Department of Neurology, the Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Na
authors.initials: N
authors.lastname: An
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China ; Department of Neurology, the Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China.
authors.forename: Yinsheng
authors.initials: Y
authors.lastname: Li
authors.affiliation: Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan Province, China ; Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, Henan Province, China ; Henan Provincial Key Laboratory of Bio-psychiatry, Xinxiang, Henan Province, China.
authors.forename: Ruiling
authors.initials: R
authors.lastname: Zhang
keywords: F-actin; NSFC grant; chronic alcoholism; cystathionine-beta-synthase; hippocampus; hydrogen sulfide; learning; memory; mitochondria; nerve regeneration; neural regeneration