title: Moisturizing effect of stable cream containing Crocus sativus extracts.
abstract: The present study is about to prepare stable cream of water-in-oil emulsion containing extracts of Crocus sativus against its base (without extracts) taken as control, to determine its stability on different storage conditions and effects on skin moisture contents and transepidermal water loss. The formulation contains 3% Crocus sativus (Saffron) concentrated extracts, and the base containing no extract, were formulated. Different stability tests were done on samples, which placed at 8°C, 25°C, 40°C and 40°C with 75% relative humidity, for 4 week period. These formulations (Creams) were applied on the cheeks of human volunteers for 8week period. To evaluate any effect produced by these formulations different skin parameters were monitored every week. The significant results of this study explored the fact that water-in-oil emulsion topical cream of saffron formulated from Crocus sativus extract has absolute physical stability at different storage conditions. The increase in skin moisture contents and changes in transepidermal water loss were significant (p<0.05) with respect to base and formulation respectively. Topical cream of Crocus sativus showed significant moisturizing effects on human skin.
authors.affiliation: Department of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.affiliation: Department of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Haji Muhammad-Shoaib
authors.initials: HM
authors.lastname: Khan
authors.affiliation: Department of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Shoaib
authors.initials: S
authors.lastname: Ashraf
authors.affiliation: Department of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Imran Shair
authors.initials: IS
authors.lastname: Mohammad
authors.affiliation: Drug Regulatory Authority of Pakistan.
authors.forename: Najam-us
authors.initials: NU
authors.lastname: Saqib
authors.affiliation: Department of pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
authors.forename: Kamran
authors.initials: K
authors.lastname: Bashir
mesh_terms: D001834:Body Water / Q000378:metabolism; D027622:Crocus; D004643:Emollients / Q000494:pharmacology*; D004655:Emulsions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009824:Ointments; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
chemical_list: D004643:Emollients; D004655:Emulsions; D009824:Ointments; D010936:Plant Extracts