title: PRC2 loss amplifies Ras signaling in cancer.
abstract: The histone-modifying PRC2 complex has an ambiguous role in cancer, bearing both oncogenic and tumor-suppressive features depending on cell type. Studies of malignant peripheral nerve sheath tumors (MPNSTs) have now identified loss-of-function mutations altering PRC2 subunits, leading to the amplification of Ras-driven transcription and conferring vulnerability to BRD4 inhibitors.
authors.affiliation: Division of Epigenomics and Cancer Risk Factors at the German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Annika
authors.initials: A
authors.lastname: Baude
authors.affiliation: Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-si, Republic of Korea.
authors.forename: Anders M
authors.initials: AM
authors.lastname: Lindroth
authors.affiliation: Division of Epigenomics and Cancer Risk Factors at the German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Plass
mesh_terms: D018797:Cell Cycle Proteins; D016514:Genes, Neurofibromatosis 1 / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D009363:Neoplasm Proteins; D009442:Neurilemmoma / Q000235:genetics*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors; D063151:Polycomb Repressive Complex 2 / Q000172:deficiency* / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000037:antagonists & inhibitors; D014158:Transcription, Genetic / Q000502:physiology; D018631:ras Proteins / Q000378:metabolism*; D000092468:Bromodomain Containing Proteins
chemical_list: D018797:Cell Cycle Proteins; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D063151:Polycomb Repressive Complex 2; D014157:Transcription Factors; D018631:ras Proteins; C441289:BRD4 protein, human; D000092468:Bromodomain Containing Proteins; C491488:EED protein, human; C430461:SUZ12 protein, human