title: Fully automated detection of diabetic macular edema and dry age-related macular degeneration from optical coherence tomography images.
abstract: We present a novel fully automated algorithm for the detection of retinal diseases via optical coherence tomography (OCT) imaging. Our algorithm utilizes multiscale histograms of oriented gradient descriptors as feature vectors of a support vector machine based classifier. The spectral domain OCT data sets used for cross-validation consisted of volumetric scans acquired from 45 subjects: 15 normal subjects, 15 patients with dry age-related macular degeneration (AMD), and 15 patients with diabetic macular edema (DME). Our classifier correctly identified 100% of cases with AMD, 100% cases with DME, and 86.67% cases of normal subjects. This algorithm is a potentially impactful tool for the remote diagnosis of ophthalmic diseases.
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham 27708, USA ; Department of Computer Science, Duke University, Durham 27708, USA.
authors.forename: Pratul P
authors.initials: PP
authors.lastname: Srinivasan
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, 02114, USA.
authors.forename: Leo A
authors.initials: LA
authors.lastname: Kim
authors.affiliation: Department of Ophthalmology, Duke University Medical Center, Durham 27710, USA.
authors.forename: Priyatham S
authors.initials: PS
authors.lastname: Mettu
authors.affiliation: Department of Ophthalmology, Duke University Medical Center, Durham 27710, USA.
authors.forename: Scott W
authors.initials: SW
authors.lastname: Cousins
authors.affiliation: Kellogg Eye Center, University of Michigan, Ann Arbor 48105, USA.
authors.forename: Grant M
authors.initials: GM
authors.lastname: Comer
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham 27708, USA ; Department of Ophthalmology, Duke University Medical Center, Durham 27710, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.affiliation: Department of Biomedical Engineering, Duke University, Durham 27708, USA ; Department of Ophthalmology, Duke University Medical Center, Durham 27710, USA ; Department of Computer Science, Duke University, Durham 27708, USA ; Department of Electrical and Computer Engineering, Duke University, Durham 27708, USA.
authors.forename: Sina
authors.initials: S
authors.lastname: Farsiu
keywords: (100.0100) Image processing; (100.2960) Image analysis; (100.5010) Pattern recognition; (110.4500) Optical coherence tomography; (170.4470) Ophthalmology