title: Oral administration of Bifidobacterium spp. improves insulin resistance, induces adiponectin, and prevents inflammatory adipokine expressions.
abstract: The intestinal microbiome might be an important contributor to the development of type 2 diabetes. This study was designed to test the hypothesis that oral administration of Bifidobacterium species (spp.) (including B. longum, B. bifidum, B. infantis, and B. animalis) may both ameliorate insulin resistance and reduce the expressions of inflammatory adipocytokines. Male Swiss-Webster mice fed a high-fat diet with or without oral administration of Bifidobacterium spp. for 5 weeks were subjected to an insulin tolerance test and an oral glucose tolerance test. Plasma levels of glucose at 30, 60, 90 and 120 min after insulin injection or glucose administration were significantly lower in the Bifidobacterium spp. than in the control group (P < 0.05), showing the beneficial effect of oral administration on insulin resistance in obese Swiss mice. In addition, Bifidobacterium spp. increased the adiponectin mRNA level and decreased those of monocyte chemoattractant protein 1 and interleukin 6 in non-diabetic C57BL/6J mice fed a normal diet, indicating a molecular mechanism which may ameliorate the inflammatory state, thereby reducing insulin resistance. In conclusion, oral administration of Bifidobacterium spp. improves insulin resistance and glucose tolerance in obese mice by reducing inflammation, as it does in the lean state.
authors.affiliation: Department of Food Microbiology, National Institute for Food Control.
authors.forename: Thi Kim Chung
authors.initials: TK
authors.lastname: LE
authors.forename: Toshio
authors.initials: T
authors.lastname: Hosaka
authors.forename: Thi Thanh Tam
authors.initials: TT
authors.lastname: LE
authors.forename: Thi Giang
authors.initials: TG
authors.lastname: Nguyen
authors.forename: Quang Binh
authors.initials: QB
authors.lastname: Tran
authors.forename: Thi Hong Hao
authors.initials: TH
authors.lastname: LE
authors.forename: Xuan Da
authors.initials: XD
authors.lastname: Pham
mesh_terms: D054392:Adipokines / Q000235:genetics*; D052242:Adiponectin / Q000235:genetics*; D000284:Administration, Oral; D000818:Animals; D001644:Bifidobacterium / Q000502:physiology*; D018932:Chemokine CCL2 / Q000235:genetics; D003924:Diabetes Mellitus, Type 2; D059305:Diet, High-Fat; D005786:Gene Expression Regulation; D005951:Glucose Tolerance Test; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D054392:Adipokines; D052242:Adiponectin; D018932:Chemokine CCL2; D015850:Interleukin-6; D012333:RNA, Messenger