title: Characterization of Cr(V)-induced genotoxicity using CdTe nanocrystals as fluorescent probes.
abstract: CdTe nanocrystals capped by cysteamine were synthesized to study Cr(V)-induced genotoxicity. On the surface of TiO2 thin films, the stepwise process of DNA breakage induced by Cr(V)-GSH complexes was vividly observed by using CdTe-DNA self-assembled fluorescent probes; in acetate buffer solution, an analytical method was developed to detect Cr(V)-induced genotoxicity with CdTe fluorescent probes.
authors.affiliation: Henan Provincial Center for Disease Control and Prevention, Henan, Zhengzhou, 450003, People's Republic of China. cdcwhzhang@gmail.com.
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Zhang
authors.forename: Chao-Xia
authors.initials: CX
authors.lastname: Sui
authors.forename: Xie
authors.initials: X
authors.lastname: Wang
authors.forename: Gong-Ju
authors.initials: GJ
authors.lastname: Yin
authors.forename: Ying-Fan
authors.initials: YF
authors.lastname: Liu
authors.forename: Ding
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry*; D002417:Cattle; D002840:Chromates / Q000633:toxicity*; D004247:DNA / Q000648:ultrastructure; D053938:DNA Fragmentation / Q000187:drug effects*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005978:Glutathione / Q000633:toxicity*; D008856:Microscopy, Fluorescence; D009153:Mutagens / Q000633:toxicity*; D053758:Nanoparticles / Q000737:chemistry*; D013691:Tellurium / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D002840:Chromates; D005456:Fluorescent Dyes; D009153:Mutagens; C066097:chromium(V)-glutathione complex; D004247:DNA; C427203:calf thymus DNA; D005978:Glutathione; D013691:Tellurium; C028337:cadmium telluride