title: A generator-produced gallium-68 radiopharmaceutical for PET imaging of myocardial perfusion.
abstract: Lipophilic cationic technetium-99m-complexes are widely used for myocardial perfusion imaging (MPI). However, inherent uncertainties in the supply chain of molybdenum-99, the parent isotope required for manufacturing 99Mo/99mTc generators, intensifies the need for discovery of novel MPI agents incorporating alternative radionuclides. Recently, germanium/gallium (Ge/Ga) generators capable of producing high quality 68Ga, an isotope with excellent emission characteristics for clinical PET imaging, have emerged. Herein, we report a novel 68Ga-complex identified through mechanism-based cell screening that holds promise as a generator-produced radiopharmaceutical for PET MPI.
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Jothilingam
authors.initials: J
authors.lastname: Sivapackiam
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Harpstrite
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Julie L
authors.initials: JL
authors.lastname: Prior
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: Hannah
authors.initials: H
authors.lastname: Gu
authors.affiliation: Department of Chemistry and Biochemistry, University of Missouri, St. Louis, Missouri, United States of America.
authors.forename: Nigam P
authors.initials: NP
authors.lastname: Rath
authors.affiliation: BRIGHT Institute, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America; Departments of Cell Biology and Physiology and Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America.
authors.forename: David
authors.initials: D
authors.lastname: Piwnica-Worms
mesh_terms: D000818:Animals; D002460:Cell Line; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D005710:Gallium Radioisotopes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D008297:Male; D051379:Mice; D055414:Myocardial Perfusion Imaging / Q000379:methods; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods*; D011876:Radionuclide Generators; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D005029:Ethylenediamines; D005710:Gallium Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals