title: Acute morphine and cocaine related death after trimethoprim-adultered cocaine abuse.
abstract: Over the last few decades, cocaine and morphine (heroin) have been among the primary causes of deaths related to drug abuse. Cocaine is frequently altered by dilution, substitution, contamination, and adulteration. Trimethoprim has never been identified in the powders of cocaine, making this the first post-mortem case report in which the presence of this compound is described. The case reported here is that of a 46-year-old woman with a history of cocaine and morphine abuse who was found dead inside her bathroom. The police found the corpse next to a syringe, with a telephone card containing trace of cocaine on the sink. Toxicological analysis was performed, and drug levels were measured by means of gas chromatography/mass spectrometry. In addition to the presence of cocaine and smaller alkaloids, trimethoprim was also detected on the syringe and telephone card and in the woman's nasal mucosa. Trimethoprim analysis is very quick and easy and can be added to the routine analysis of drugs of abuse seized on the illicit market to obtain more information.
authors.affiliation: Institute of Public Health, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Largo F. Vito, Rome, Italy nadiafucci@rm.unicatt.it.
authors.forename: Nadia
authors.initials: N
authors.lastname: Fucci
authors.affiliation: Institute of Public Health, Section of Legal Medicine, Università Cattolica del Sacro Cuore, Largo F. Vito, Rome, Italy.
authors.forename: Vincenzo L
authors.initials: VL
authors.lastname: Pascali
mesh_terms: D003042:Cocaine / Q000097:blood / Q000652:urine; D019970:Cocaine-Related Disorders / Q000175:diagnosis* / Q000401:mortality*; D065687:Cytochrome P-450 CYP2C8 Inhibitors; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D009020:Morphine / Q000097:blood / Q000652:urine; D014295:Trimethoprim
chemical_list: D065687:Cytochrome P-450 CYP2C8 Inhibitors; D009020:Morphine; D014295:Trimethoprim; D003042:Cocaine
keywords: comparative analysis; illicit cocaine; trimethoprim