title: The SCF/c-KIT system in the male: Survival strategies in fertility and cancer.
abstract: Maintaining the delicate balance between cell survival and death is of the utmost importance for the proper development of germ cells and subsequent fertility. On the other hand, the fine regulation of tissue homeostasis by mechanisms that control cell fate is a factor that can prevent carcinogenesis. c-KIT is a type III receptor tyrosine kinase activated by its ligand, stem cell factor (SCF). c-KIT signaling plays a crucial role in cell fate decisions, specifically controlling cell proliferation, differentiation, survival, and apoptosis. Indeed, deregulating the SCF/c-KIT system by attenuation or overactivation of its signaling strength is linked to male infertility and cancer, and rebalancing its activity via c-KIT inhibitors has proven beneficial in treating human tumors that contain gain-of-function mutations or overexpress c-KIT. This review addresses the roles of SCF and c-KIT in the male reproductive tract, and discusses the potential application of c-KIT target therapies in disorders of the reproductive system.
authors.affiliation: CICS-UBI-Health Sciences Research Centre, University of Beira Interior, Covilhã, Portugal.
authors.forename: Henrique J
authors.initials: HJ
authors.lastname: Cardoso
authors.forename: Marília I
authors.initials: MI
authors.lastname: Figueira
authors.forename: Sara
authors.initials: S
authors.lastname: Correia
authors.forename: Cátia V
authors.initials: CV
authors.lastname: Vaz
authors.forename: Sílvia
authors.initials: S
authors.lastname: Socorro
mesh_terms: D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D005298:Fertility / Q000502:physiology*; D005835:Genitalia / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D019089:Stem Cell Factor / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit