title: Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae.
abstract: Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersinia pestis, are able to survive in a large variety of environmental reservoirs (e.g., soil, plants, insects) as well as warm-blooded animals (e.g., rodents, pigs, humans) with a particular preference for lymphatic tissues. In order to manage rapidly changing environmental conditions and interbacterial competition, Yersinia senses the nutritional composition during the course of an infection by special molecular devices, integrates this information and adapts its metabolism accordingly. In addition, nutrient availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Recent studies revealed that global regulatory factors such as the cAMP receptor protein (Crp) and the carbon storage regulator (Csr) system are part of a large network of transcriptional and posttranscriptional control strategies adjusting metabolic changes and virulence in response to temperature, ion and nutrient availability. Gained knowledge about the specific metabolic requirements and the correlation between metabolic and virulence gene expression that enable efficient host colonization led to the identification of new potential antimicrobial targets.
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Institut für Mikrobiology, Technische Universität Braunschweig Braunschweig, Germany.
authors.forename: Ann Kathrin
authors.initials: AK
authors.lastname: Heroven
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Institut für Mikrobiology, Technische Universität Braunschweig Braunschweig, Germany.
authors.forename: Petra
authors.initials: P
authors.lastname: Dersch
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007109:Immunity; D008018:Life Cycle Stages; D053858:Metabolic Networks and Pathways; D014774:Virulence; D037521:Virulence Factors; D015007:Yersinia / Q000254:growth & development / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity*; D015009:Yersinia Infections / Q000276:immunology / Q000382:microbiology*
chemical_list: D037521:Virulence Factors
keywords: Crp; Csr; Yersinia; gene regulation; host-adapted metabolism; virulence