title: Clinical guidelines for gynecologic care after hematopoietic SCT. Report from the international consensus project on clinical practice in chronic GVHD.
abstract: Despite similarities relevant age- and gender-specific issues exist in the care of patients after allogeneic hematopoietic SCT (HSCT). Female genital chronic GVHD (cGVHD) has been markedly underreported in the past but has a significant impact on the patients' health and quality of life. Data on prevention and treatment of this complication are still limited. Here we present a comprehensive review summarizing the current knowledge, which was discussed during several meetings of the German, Austrian and Swiss Consensus Project on clinical practice in cGVHD. In this report, we provide recommendations for post-transplant gynecological care of cGVHD manifestations agreed upon by all participants. This includes guidelines for diagnosis, prevention, and therapeutic options and topical treatments in female patients with genital cGVHD and hormonal replacement treatment of premature ovarian failure for adult and pediatric patients and underlines the necessity for regular gynecological care and screening programs for women after HSCT.
authors.affiliation: Women's Hospital, Cantonal Hospital Baselland, Bruderholz, Switzerland.
authors.forename: B
authors.initials: B
authors.lastname: Frey Tirri
authors.affiliation: Department of Dermatology, University Hospital Basel, Basel, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Häusermann
authors.affiliation: Department of Hematology and Oncology, Albert Ludwigs-University Medical Center, Freiburg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Bertz
authors.affiliation: Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.
authors.forename: H
authors.initials: H
authors.lastname: Greinix
authors.affiliation: St Anna Children's Hospital, Medical University of Vienna, Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Lawitschka
authors.affiliation: University Children's Hospital Tuebingen, Tuebingen, Germany.
authors.forename: C-P
authors.initials: CP
authors.lastname: Schwarze
authors.affiliation: Department of Medicine III, University of Regensburg, Regensburg, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Wolff
authors.affiliation: Department of Hematology, University Hospital Basel, Basel, Switzerland.
authors.forename: J P
authors.initials: JP
authors.lastname: Halter
authors.affiliation: Department of General Gynecology and Gynecological Oncology, Medical University of Vienna, Vienna, Austria.
authors.forename: D
authors.initials: D
authors.lastname: Dörfler
authors.affiliation: 1] Clinic for Gynecological Endocrinology and Reproductive Medicine, University Hospital Basel, Basel, Switzerland [2] Fertisuisse, Center for Reproductive Medicine, Olten, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Moffat
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D020249:Hormone Replacement Therapy; D006801:Humans; D017410:Practice Guidelines as Topic; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis / Q000517:prevention & control; D014932:Women's Health Services