title: Gold nanoparticles for photothermally controlled drug release.
abstract: In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is used to release a drug. Then, we describe the four major functionalization strategies and each of their different applications. Finally, we discuss the biodistribution and toxicity of these systems and the necessary requirements for the use of gold nanoparticles for spatially and temporally controlling drug release through the photothermal effect.
authors.affiliation: Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile. Santos Dumont 964, Independencia, Santiago, Chile.
authors.forename: Ariel R
authors.initials: AR
authors.lastname: Guerrero
authors.forename: Natalia
authors.initials: N
authors.lastname: Hassan
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Escobar
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kogan
authors.forename: Eyleen
authors.initials: E
authors.lastname: Araya
mesh_terms: D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006046:Gold / Q000627:therapeutic use*; D006358:Hot Temperature; D006801:Humans; D008027:Light; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D043942:Nanotubes / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011092:Polyethylene Glycols / Q000627:therapeutic use
chemical_list: D003692:Delayed-Action Preparations; D011092:Polyethylene Glycols; D006046:Gold
keywords: cancer; drug delivery; near-infrared irradiation; photothermal release; spatial and temporal release