title: Evaluation of epicardial fat tissue thickness as a marker of cardiovascular risk in patients with subclinical hypothyroidism.
abstract: BACKGROUND
  Epicardial fat thickness (EFT) has been evaluated as a marker of cardiovascular disease, with good correlation with classical cardiovascular risk factors in the general population. The aim of this study was to evaluate the EFT in subclinical hypothyroidism (SCH), in comparison to a group without thyroid dysfunction.
  
  
  METHODS
  A cross-sectional study was performed with 100 participants, including 52 SCH patients and 48 individuals without any thyroid dysfunction (euthyroid group-EU). Transthoracic echocardiography (TE), thyroid hormone levels, lipid profile, and assessment of body composition by bioelectrical impedance (BIA) and anthropometry were measured in all subjects.
  
  
  RESULTS
  The SCH and EU groups were comparable with respect to age, gender, and Framingham risk scores. Serum thyroid-stimulating hormone (TSH) was 6.7 ± 1.4 mIU/L in the SCH group and 2.0 ± 0.84 mIU/L in the control group. EFT was similar in both groups (SCH 3.5 ± 1.3 mm, EU 3.5 ± 1.1 mm, p = 0.43). EFT showed a slight trend for a positive correlation with serum TSH in the SCH group (r s = 0.263, p = 0.05). EFT correlated with the body fat percentage in the SCH group (r s = 0.350, p = 0.03) and EU group (r s = 0.033, p = 0.04). EFT in this cohort was not independently correlated to changes in TSH and Framingham risk score.
  
  
  CONCLUSIONS
  EFT determination by TE does not seem to be a good marker of cardiovascular risk in SCH patients with serum TSH <10.0 mIU/L and no pre-existing cardiovascular morbidity.
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. o1gacs@yahoo.com.br.|Endocrinology Service, Clementino Fraga Filho University Hospital, Rua Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil. o1gacs@yahoo.com.br.
authors.forename: O C
authors.initials: OC
authors.lastname: Santos
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: N A O
authors.initials: NA
authors.lastname: Silva
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.|Endocrinology Service, Clementino Fraga Filho University Hospital, Rua Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil.
authors.forename: M
authors.initials: M
authors.lastname: Vaisman
authors.affiliation: Cardiology Service, Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil.
authors.forename: M D
authors.initials: MD
authors.lastname: Turano
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: M G
authors.initials: MG
authors.lastname: Dytz
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: G A
authors.initials: GA
authors.lastname: Huber
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.|Nutrition and Metabolism Service, Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil.
authors.forename: V B
authors.initials: VB
authors.lastname: Braulio
authors.affiliation: Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.|Endocrinology Service, Clementino Fraga Filho University Hospital, Rua Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro, RJ, 21941-913, Brazil.
authors.forename: P F S
authors.initials: PF
authors.lastname: Teixeira
mesh_terms: D050154:Adiposity; D000328:Adult; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D015415:Biomarkers
keywords: Cardiovascular risk; Epicardial fat tissue; Subclinical hypothyroidism; Transthoracic echocardiogram