title: Salt-enabled visual detection of DNA.
abstract: We report herein a label-free, salt-enabled visual detection strategy for DNA, based on the alteration of surface adhesion properties of salt solution, which can translate to the change in the size of the salt residue upon drying, with self-assembled DNA nanostructures. This environmentally friendly array assay protocol enables the achievement of a detection sensitivity comparable to classic colorimetric methods, single-base mismatch differentiation selectivity, multiple-target detection capability, RNA target detection, and a ligase chain reaction-rolling circle amplification implementation format.
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing National Laboratory of Microstructures, Nanjing University, Nanjing 210093, China. jinz@nju.edu.cn.
authors.forename: Xilong
authors.initials: X
authors.lastname: Wang
authors.forename: Xun
authors.initials: X
authors.lastname: Chen
authors.forename: Sha
authors.initials: S
authors.lastname: Sun
authors.forename: Feifei
authors.initials: F
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D004247:DNA / Q000032:analysis*; D017931:DNA Primers / Q000737:chemistry / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry; D021141:Nucleic Acid Amplification Techniques; D012492:Salts / Q000737:chemistry*
chemical_list: D017931:DNA Primers; D012492:Salts; D004247:DNA