title: [Marked effect of botulinum toxin A for severe toe digital ulcers in a patient with systemic sclerosis].
abstract: In this case we describe a successful combined treatment with local anaesthetics and botulinum toxin A. A 61-year-old man with systemic sclerosis of limited type presented treatment refractory digital ulcers on his toes with a poor response to conventional treatment. A combined treatment as above-mentioned prevented a threatening amputation and improved quality of life, reduction of pain and healing of wounds. Using botulinum toxin A combined with local anaesthetics to severe toe digital ulcers in patients with systemic sclerosis may be a solution, when other treatments have been ineffective and amputation seems to be the last option.
authors.affiliation: Dermatologisk Afdeling S, Aarhus Universitetshospital, P.P. Ørumsgade 11, 8000 Aarhus C. janbau@rm.dk.
authors.forename: Jane Baumgartner
authors.initials: JB
authors.lastname: Nielsen
authors.forename: Lone
authors.initials: L
authors.lastname: Hvid
authors.forename: Anne Braae
authors.initials: AB
authors.lastname: Olesen
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology; D012883:Skin Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014034:Toes / Q000098:blood supply / Q000473:pathology
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A