title: Are MHC class II-restricted cytotoxic T lymphocytes important?
abstract: Although most cytotoxic T lymphocytes (CTL) are MHC class I restricted and most helper T cells class II restricted, some CTL are MHC class II restricted. The function of these cells is unclear. Here, Eric Braakman and co-workers suggest that they are an important regulatory influence, appearing late in the immune response and destroying cells presenting antigen in the context of class II molecules. The elimination of these cells inhibits the generation of the helper T response and consequently terminates the immune response to that antigen.
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, PO Box 9406, 1006 AK Amsterdam, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Braakman
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, PO Box 9406, 1006 AK Amsterdam, The Netherlands.
authors.forename: F T
authors.initials: FT
authors.lastname: Rotteveel
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, PO Box 9406, 1006 AK Amsterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: van Bleek
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, PO Box 9406, 1006 AK Amsterdam, The Netherlands.
authors.forename: G A
authors.initials: GA
authors.lastname: van Seventer
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, incorporating the Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, PO Box 9406, 1006 AK Amsterdam, The Netherlands.
authors.forename: C J
authors.initials: CJ
authors.lastname: Lucas