title: γδ T cells as a potential tool in colon cancer immunotherapy.
abstract: γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.
authors.affiliation: Department of Biopathology & Biomedical Methodologies, University of Palermo, Palermo, Italy.
authors.forename: Thiranut
authors.initials: T
authors.lastname: Ramutton
authors.forename: Simona
authors.initials: S
authors.lastname: Buccheri
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Matilde
authors.initials: M
authors.lastname: Todaro
authors.forename: Giorgio
authors.initials: G
authors.lastname: Stassi
authors.forename: Serena
authors.initials: S
authors.lastname: Meraviglia
mesh_terms: D003110:Colonic Neoplasms / Q000276:immunology* / Q000628:therapy*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007167:Immunotherapy; D008024:Ligands; D014411:Neoplastic Stem Cells / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D008024:Ligands; D016692:Receptors, Antigen, T-Cell, gamma-delta
keywords: HDAC inhibitor; MICA/B; NKG2D-mediated killing; Vγ9Vγ2 T cells; colon cancer; immune surveillance; immunotherapy