title: Experimental study on the viscosity and adhesive performance of exogenous liquid fibrin glue.
abstract: Exogenous fibrin glue (FG) is highly suitable for neurosurgical procedures, because of its viscosity and adhesive properties. Several FGs are commercially available, but only few reports detail their differences. In the present study, we investigated the viscosity and adhesive performance of two types of FG: one is derived from blood donated in Europe and the United States (CSL Behring's Beriplast(®), BP) and the other is derived from blood donated in Japan (the Chemo-Sero-Therapeutic Research Institute's Bolheal(®), BH). The viscosity test that measured fibrinogen viscosity revealed that BP had significantly higher viscosity than BH. Similarly, the dripping test showed that BP traveled a significantly shorter drip distance in the vertical direction than BH, although the transverse diameter of the coagulated FG did not differ statistically significantly. In the tensile strength test, BP showed superior adhesion performance over BH. The histological study of the hematoxylin-eosin-stained specimens in both groups showed favorable adhesion. Although further studies are required on its manufacturing and usage methods, FG shows differences in viscosity and adhesive performance according to the blood from which it is derived. We conclude that it is desirable to select the type and usage method of FG according to the characteristics of the surgical operation in question. Our findings suggest that FG produced from the blood donated in Europe and the United States might be more suitable for use in surgical procedures that demand an especially high degree of viscosity and rapid adhesive performance.
authors.affiliation: Department of Neurosurgery, Fujita Health University, School of Medicine.
authors.forename: Takuro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Joji
authors.initials: J
authors.lastname: Inamasu
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Adachi
authors.forename: Shinya
authors.initials: S
authors.lastname: Nagahisa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hirose
mesh_terms: D000268:Adhesiveness; D004338:Drug Combinations; D005060:Europe; D005176:Factor XIII / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005340:Fibrinogen / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D019635:Neurosurgical Procedures / Q000379:methods*; D013718:Tensile Strength; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014481:United States; D014783:Viscosity
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII