title: A new organocatalytic concept for asymmetric α-alkylation of aldehydes.
abstract: The organocatalytic asymmetric α-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts, α-diarylmethine-substituted aldehydes with two contiguous stereocenters have been synthesized in a simple manner with good diastereocontrol and excellent enantioselectivity.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University , DK-8000 Aarhus C, Denmark.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Caruana
authors.forename: Florian
authors.initials: F
authors.lastname: Kniep
authors.forename: Tore Kiilerich
authors.initials: TK
authors.lastname: Johansen
authors.forename: Pernille H
authors.initials: PH
authors.lastname: Poulsen
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen