title: Targeted drug delivery to central nervous system (CNS) for the treatment of neurodegenerative disorders: trends and advances.
abstract: The treatment of brain diseases has been a major challenge since a long time. Although there are several potent drugs, which are highly therapeutic yet their efficiency is marred due to the presence of the Blood Brain Barrier (BBB). The BBB, which is present at the capillary level regulates and monitors the entry of all small and large molecules entering into the brain. Although this barrier is of immense importance to the brain in terms of safety, it becomes a hindrance when it comes to therapy because the drug molecules are unable to reach the brain. Various biomaterial-based strategies are being developed to overcome the BBB and deliver the drug into the brain. These include polymeric nanoparticles, liposomes, solid-lipid nanoparticles (SLNPs), nanogels, implants, etc. This review provides an overview on CNS disorders, BBB, and various delivery strategies available for biologists engaged in translational neuroscience, to target CNS.
authors.forename: Kritika
authors.initials: K
authors.lastname: Goyal
authors.forename: Veena
authors.initials: V
authors.lastname: Koul
authors.forename: Yashveer
authors.initials: Y
authors.lastname: Singh
authors.affiliation: Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. akshay1anand@rediffmail.com.
authors.forename: Akshay
authors.initials: A
authors.lastname: Anand
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000378:metabolism; D016503:Drug Delivery Systems / Q000639:trends*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D004364:Pharmaceutical Preparations