title: LIN28B promotes colon cancer migration and recurrence.
abstract: LIN28B is involved in "stemness" and tumourigenesis by negatively regulating the maturation of let-7 microRNA family members. In this study, we showed that LIN28B expression promotes migration and recurrence of colon cancer. Immunohistochemistry and reverse-transcription polymerase chain reactions were performed to detect LIN28B expression in colon cancer tissue microarrays, paraffin-embedded surgical resected tissues and cancer cells. Loss-of-function, migration and proliferation analyses were performed to delineate the potential roles of LIN28B in colon cancer. LIN28B was upregulated in colon cancer tissue compared to normal mucosa, and its overexpression correlated with reduced patient survival and increased tumour recurrence. LIN28B suppression inhibited the migration of SW480 colon cancer cells and facilitated the cytotoxicity induced by oxaliplatin in SW480 and HCT116 colon cancer cells. In conclusion, LIN28B overexpression contributes to colon tumourigenesis, and LIN28B may serve as a diagnostic tool and therapeutic target for colon cancer.
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Minghui
authors.initials: M
authors.lastname: Pang
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Hou
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Nengyi
authors.initials: N
authors.lastname: Hou
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Liang
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Guiqing
authors.initials: G
authors.lastname: Jia
authors.affiliation: Department of Health Management Centre, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Shuai
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Luo
authors.affiliation: Department of General Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, People's Republic of China.
authors.forename: Kang
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
authors.forename: Guoxin
authors.initials: G
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement; D003110:Colonic Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D045325:HCT116 Cells / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009944:Organoplatinum Compounds / Q000494:pharmacology; D000077150:Oxaliplatin; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D012016:Reference Values; D046888:Tissue Array Analysis; D015854:Up-Regulation
chemical_list: D000970:Antineoplastic Agents; C516326:LIN28B protein, human; D009944:Organoplatinum Compounds; D016601:RNA-Binding Proteins; D000077150:Oxaliplatin