title: Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial.
abstract: This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5 g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60 min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.
authors.affiliation: 1 Department of Food Science and Technology, Seoul National University of Science and Technology , Seoul, Korea.
authors.forename: Ji Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Hyang Mok
authors.initials: HM
authors.lastname: Ok
authors.forename: Joohee
authors.initials: J
authors.lastname: Kim
authors.forename: Seok Won
authors.initials: SW
authors.lastname: Park
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Kwon
authors.forename: Oran
authors.initials: O
authors.lastname: Kwon
mesh_terms: D019540:Area Under Curve; D001681:Biological Assay; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000378:metabolism; D019587:Dietary Supplements; D004311:Double-Blind Method; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D031625:Morus; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D019518:Postprandial Period; D011236:Prediabetic State / Q000097:blood / Q000188:drug therapy*
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts
keywords: 1-deoxynojirimycin; mulberry leaf aqueous extract; postprandial glycemic control