title: Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with endometrial hyperplasia and endometrial cancer.
abstract: OBJECTIVE
  Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and platelet distribution width (PDW) may indicate the systemic inflammatory response associated with various cancers. We aimed to investigate the relationship between NLR, PLR, PDW and endometrial pathologies including hyperplasia and cancer.
  
  
  METHODS
  In this study, 472 cases who underwent endometrial biopsy were included. Three groups were constituted with respect to biopsy results: group 1, endometrial cancer patients (n = 54); group 2, endometrial hyperplasia patients (n = 152); and group 3, patients with normal biopsy results (n = 281). White blood cell and platelet counts as well as NLR, PLR and PDW recorded from complete blood counts obtained on the same day of biopsy were compared in the three groups.
  
  
  RESULTS
  Endometrial cancer patients were significantly older than the cases in the other two groups (P < 0.001). The NLR in group 1 was significantly higher than group 3 (P = 0.02). However, there was no difference between the three groups with respect to PLR (P = 0.167). PDW was increased in group 1 compared to group 3 (P < 0.001).
  
  
  CONCLUSIONS
  Results of our study have shown that NLR, PLR and PDW are simple, readily available and robust inflammatory markers that may be used in the management of endometrial pathologies. However, the actual predictive potential of these biomarkers still warrants further trials.
authors.affiliation: Department of Obstetrics and Gynecology, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey.
authors.forename: Ülkü Mete
authors.initials: ÜM
authors.lastname: Ural
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Şehitoğlu
authors.forename: Yeşim Bayoğlu
authors.initials: YB
authors.lastname: Tekin
authors.forename: Figen Kir
authors.initials: FK
authors.lastname: Şahin
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000097:blood*; D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000473:pathology; D018269:Carcinoma, Endometrioid / Q000097:blood*; D002291:Carcinoma, Papillary / Q000097:blood*; D004714:Endometrial Hyperplasia / Q000097:blood*; D016889:Endometrial Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes; D008875:Middle Aged; D009504:Neutrophils; D010976:Platelet Count
keywords: endometrial cancer; endometrial hyperplasia; neutrophil-to-lymphocyte ratio; platelet distribution width; platelet-to-lymphocyte ratio