title: [Studying the neuroprotective effect of the novel glutamic acid derivative neiroglutam on focal cerebral ischemia in rats].
abstract: We have studied the neuroprotective effect of the novel glutamic acid derivative neiroglutam on reversible focal cerebral ischemia in rats. The neuroprotective drug action was assessed by the ability to reduce the severity of neurological deficit (1, 2, 3, 5 and 7 days), forelimb fine-motor disorders (in the ladder test), hind limb motor activity (beam-walking test), and volume of the infarct zone upon 7-day pathologic exposure. It was found that the therapeutic administration of neiroglutam (26 mg/kg, i.p., for 7 days) reduces the volume of necrosis of cerebral tissues in case of focal brain ischemia in animals (on the average by 38%, (p < 0.05) and decreases the severity of motor disorders, which indicates the presence of neuroprotective effect of this compound.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: D V
authors.initials: DV
authors.lastname: Kurkin
authors.forename: D A
authors.initials: DA
authors.lastname: Bakulin
authors.forename: E V
authors.initials: EV
authors.lastname: Volotova
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D021461:Animals, Outbred Strains; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D004334:Drug Administration Schedule; D018698:Glutamic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D002546:Ischemic Attack, Transient / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D012720:Severity of Illness Index
chemical_list: D000596:Amino Acids; D018696:Neuroprotective Agents; C006952:cerebrolysin; D018698:Glutamic Acid