title: Study of photoinduced antitumor activity of phthalocyanin-based nanostructures as pro-photosensitizers in photodynamic therapy of malignant tumors in vivo.
abstract: Nanoparticles of aluminum and zinc phthalocyanin and metal-free phthalocyanin (AlPc, ZnPc, and H2Pc), whose molecular forms are photosensitizers, can serve as effective "prophotosensitizers" in photodynamic therapy for malignant tumors. Transition (stimulation) of photo-inert nanoparticles into a photoactive photosensitizer is realized locally in the tumor node by its exposure to potent laser pulses. Systemic injection of AlPc, ZnPc, and H2Pc nanoparticles has not led to accumulation of their photoactive form in the skin, which can lead to the development of skin phototoxicity. Effective protocols of photodynamic therapy with ZnPc nanoparticles are determined. The use of these protocols in mice with S-37 sarcoma led to 92-70% tumor growth inhibition, 48% improvement of survival, and cure in 84% cases.
authors.affiliation: P. A. Hertzen Moscow Oncological Institute, the Ministry of Health of the Russian Federation, Moscow, Russia, andreimnioi@yandex.ru.
authors.forename: A A
authors.initials: AA
authors.lastname: Pankratov
authors.forename: T N
authors.initials: TN
authors.lastname: Andreeva
authors.forename: R I
authors.initials: RI
authors.lastname: Yakubovskaya
authors.forename: B Ya
authors.initials: BY
authors.lastname: Kogan
authors.forename: A V
authors.initials: AV
authors.lastname: Butenin
authors.forename: R K-G
authors.initials: RK
authors.lastname: Feizulova
authors.forename: V A
authors.initials: VA
authors.lastname: Puchnova
authors.forename: N V
authors.initials: NV
authors.lastname: Novoseletsky
authors.forename: A V
authors.initials: AV
authors.lastname: Khromov
authors.forename: E A
authors.initials: EA
authors.lastname: Lukyanets
authors.forename: G N
authors.initials: GN
authors.lastname: Vorozhtsov
mesh_terms: D000818:Animals; D001391:Azo Compounds; D005260:Female; D005453:Fluorescence; D007093:Imidazoles; D007211:Indoles / Q000627:therapeutic use*; D054833:Isoindoles; D053685:Laser Therapy / Q000379:methods*; D051379:Mice; D049329:Nanostructures / Q000627:therapeutic use*; D009942:Organometallic Compounds; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy* / Q000532:radiotherapy*; D017967:Zinc Compounds
chemical_list: D001391:Azo Compounds; D007093:Imidazoles; D007211:Indoles; D054833:Isoindoles; D009942:Organometallic Compounds; D017319:Photosensitizing Agents; C430118:VA 061; D017967:Zinc Compounds; C052159:Zn(II)-phthalocyanine; C013647:phthalocyanine