title: Impact of ENPP1 K121Q on change of insulin resistance after web-based intervention in Korean men with diabetes and impaired fasting glucose.
abstract: Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). We hypothesized that the difference in genotype may be one of the factors that affect the outcome of intervention. We genotyped 448 men with fasting glucose≥5.6 mM/L, including 371 in subjects with K allele (KK) (69 control group [CG]; and 302 intervention group [IG]) and 77 in subjects with Q allele (KQ+QQ) (13 CG and 64 IG). The web-based intervention based on a lifestyle modification was delivered by e-mail once a month for 10 months. In the KK, IG demonstrated significantly decreased levels of fasting serum insulin (FSI) as compared to CG and homeostasis model of assessment of insulin resistance (HOMA-IR). In the KQ+QQ IG group, hemoglobin A1c (HbA1c), FSI and HOMA-IR were significantly decreased, and showed further reduction in the HOMA-IR than KQ+QQ CG. After analysis of covariance, K121Q did significantly influence the change of HbA1c in CG after appropriate adjustment. In a multivariate model, BMI change predicted HOMA-IR change (adjusted β=0.801; P=0.022) in KK IG subjects with T2DM. ENPP1 K121Q did not influence the change in IR. However, individuals with T2DM carrying the K121 variant are very responsive to the effect of BMI reduction on HOMA-IR.
authors.affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
authors.forename: Ji Yeon
authors.identifier: 0000-0002-1841-5357
authors.initials: JY
authors.lastname: Kang
authors.affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
authors.forename: Sook Hee
authors.identifier: 0000-0001-8308-2301
authors.initials: SH
authors.lastname: Sung
authors.affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
authors.forename: Yeon Ju
authors.identifier: 0000-0002-9725-6269
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Central Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Daejeon, Korea.
authors.forename: Tae In
authors.identifier: 0000-0002-7389-9921
authors.initials: TI
authors.lastname: Choi
authors.affiliation: Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea.
authors.forename: Seung Jin
authors.identifier: 0000-0002-4488-187X
authors.initials: SJ
authors.lastname: Choi
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005247:Feeding Behavior; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D020407:Internet; D008019:Life Style; D008297:Male; D008875:Middle Aged; D010727:Phosphoric Diester Hydrolases / Q000235:genetics*; D011755:Pyrophosphatases / Q000235:genetics*; D056910:Republic of Korea; D015431:Weight Loss / Q000235:genetics
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010727:Phosphoric Diester Hydrolases; D011755:Pyrophosphatases; C517652:hemoglobin A1c protein, human; C065962:ectonucleotide pyrophosphatase phosphodiesterase 1
keywords: Diabetes Mellitus; Ectoenzyme Nucleotide Pyrophosphate Phosphodiesterase 1; Insulin Resistance; Web-Based Lifestyle Intervention