title: Synergistic dual-targeting hydrogel improves targeting and anticancer effect of Taxol in vitro and in vivo.
abstract: A synergistic dual-targeting molecular self-assembly hydrogel was designed with estrone (Et) and Arg-Gly-Asp (RGD) peptide. Confocal imaging in vitro and real-time visualization in vivo researches were carried out to evidence enhanced targeted delivery and anticancer effect of Taxol.
authors.affiliation: Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, 211198, P. R. China. wyzhong@cpu.edu.cn.
authors.forename: Chang
authors.initials: C
authors.lastname: Shu
authors.forename: Ruixin
authors.initials: R
authors.lastname: Li
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yin
authors.forename: Deyan
authors.initials: D
authors.lastname: Yin
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Gu
authors.forename: Li
authors.initials: L
authors.lastname: Ding
authors.forename: Wenying
authors.initials: W
authors.lastname: Zhong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001943:Breast Neoplasms / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents / Q000737:chemistry; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004970:Estrone / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D007208:Indocyanine Green / Q000737:chemistry; D061986:MCF-7 Cells; D008819:Mice, Nude; D009842:Oligopeptides / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D004337:Drug Carriers; D020100:Hydrogels; D009842:Oligopeptides; D004970:Estrone; C047981:arginyl-glycyl-aspartic acid; D007208:Indocyanine Green; D017239:Paclitaxel