title: Optical coherence tomography of fovea before and after laser treatment in retinopathy of prematurity.
abstract: OBJECTIVE
  To study the fovea in preterm babies with Type I retinopathy of prematurity (ROP) before and after laser treatment using optical coherence tomography (OCT).
  
  
  METHODS
  This was a prospective observational case-control study including preterm neonates undergoing screening for ROP from May 2009 to July 2011. Group 1 included 30 eyes of 15 neonates with Type I ROP. A 532-nm laser was used for treatment in all cases for Group 1. Group 2 included 14 eyes of 7 preterm neonates without ROP that served as controls. OCT was performed under sedation in the lateral position before and after laser treatment. P <0.05 was considered statistically significant.
  
  
  RESULTS
  The mean initial central macular thickness (CMT) was comparable in both groups (P = 0.832) and statistically significantly correlated with gestational age (P = 0.015). No adverse effects on the anterior segment or posterior segment were observed. There was no significant difference in CMT before and after laser treatment in Group 1 (P = 0.007). There was one case of cystoid macular edema after laser treatment.
  
  
  CONCLUSIONS
  The macula in preterm babies with Type 1 ROP was comparable to those without ROP. Gestational age was the only predictor of CMT.
authors.affiliation: Department of Ophthalmology, Government Medical College Hospital, Chandigarh, India.
authors.forename: Subina
authors.initials: S
authors.lastname: Narang
authors.affiliation: Department of Ophthalmology, Government Medical College Hospital, Chandigarh, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Singh
authors.affiliation: Department of Pediatrics, Government Medical College Hospital, Chandigarh, India.
authors.forename: Suksham
authors.initials: S
authors.lastname: Jain
authors.affiliation: Department of Ophthalmology, Government Medical College Hospital, Chandigarh, India.
authors.forename: Sunandan
authors.initials: S
authors.lastname: Sood
authors.affiliation: Department of Pediatrics, Government Medical College Hospital, Chandigarh, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Chawla
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005584:Fovea Centralis; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007234:Infant, Premature; D008266:Macula Lutea; D008297:Male; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: 532-nm Laser; Laser; Optical Coherence Tomography; Preterm Babies; Retinopathy of Prematurity