title: Common Polymorphisms in the GSK3β Gene May Contribute to the Pathogenesis of Alzheimer Disease: A Meta-Analysis.
abstract: OBJECTIVE
  Although it is well known that GSK3β participates in the proliferation and survival of various tumor cells, its role in diseases of the central nervous system has been sparsely documented. In the past few years, studies regarding the relationship between GSK3β rs334558 T>C and rs6438552 C>T polymorphisms and Alzheimer disease (AD) risk have yielded contradictory results. As such, this meta-analysis seeks to satisfy the need to further investigate this relationship.
  
  
  METHODS
  In this research, published studies regarding the association of GSK3β rs6438552 and rs334558 mutation with AD risk was systematically assessed. Studies were retrieved from MEDLINE, Science Citation Index, the Cochrane Library, PubMed, Embase, CINAHL, Current Contents Index, Chinese Biomedical, Chinese Journal Full-Text, and Weipu Journal. Pooled odds ratios and 95% confidence intervals were calculated for allele contrast and homozygous, heterozygous, dominant, and recessive genetic model comparisons.
  
  
  RESULTS
  It was found that GSK3β rs334558 T>C and rs6438552 C>T polymorphisms were correlated with susceptibility to AD under 4 genetic models (all P<.05). In country-stratified subgroups, the results showed increased risk of developing AD in rs334558 T>C polymorphism among Chinese and Spain populations in majority groups. GSK3β rs6438552 C>T polymorphism was correlated with increased the risk of developing AD only in Australian populations.
  
  
  CONCLUSIONS
  Our findings suggest that there exists a significant association between GSK3β rs334558 T>C polymorphism and increased susceptibility of AD. Moreover, future updated studies with stratified case-control population are warranted for validation studies.
authors.affiliation: Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, PR China caoyunpeng528@yeah.net.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Lin
authors.affiliation: Department of Neurology, the First Hospital of China Medical University, Shenyang, PR China.
authors.forename: Yun-Peng
authors.initials: YP
authors.lastname: Cao
authors.affiliation: Department of Anatomy, the First Hospital of China Medical University, Shenyang, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Gao
mesh_terms: D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D001315:Australia; D002681:China / Q000208:ethnology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D013030:Spain / Q000208:ethnology
chemical_list: C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3
keywords:      GSK3β; Alzheimer disease; genetic polymorphism; meta-analysis