title: Clinical features of adult patients with acute hepatitis B virus infection progressing to chronic infection.
abstract: Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18-84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection.
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan.
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hiraoka
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tokumoto
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Ninomiya
authors.affiliation: Gastroenterology Center, Ehime Prefectural Central Hospital, Kasugamachi 83, Matsuyama, Ehime 790-0024, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ninomiya
authors.affiliation: Department of Internal Medicine, Saiseikai Imabari Hospital, Imabari 794-0054, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Horiike
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
authors.forename: Masanori
authors.identifier: 0000-0003-4489-9102
authors.initials: M
authors.lastname: Abe
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon 791-0295, Japan.
authors.forename: Yoichi
authors.identifier: 0000-0003-4117-339X
authors.initials: Y
authors.lastname: Hiasa