title: Memory impairment following right cerebellar infarction: a case study.
abstract: We reported a patient with a right cerebellar infarction who showed anterograde amnesia. Cognitive dysfunction caused by cerebellar lesions was called cerebellar cognitive affective syndrome, and deactivation of the contralateral prefrontal cortex function due to disconnections of cerebello-cerebral fiber tracts have been hypothesized as mechanism underlying the syndrome. The episodic memory impairment, however, could not be supported by the same mechanism because the prefrontal lesions cannot cause amnesia syndrome. The feature of the impairment of our patient was similar to that of diencephalic amnesia, and a single photon emission computed tomography study showed a relative hypoperfusion in the right cerebellar hemisphere and left anterior thalamus. We considered that the memory deficit was caused by the dysfunction of the thalamus, which is a relay center of the cerebello-cerebral connectivity network.
authors.affiliation: a Department of Neurology , Toranomon Hospital , Tokyo , Japan.
authors.forename: Fumiko Kusunoki
authors.initials: FK
authors.lastname: Nakamoto
authors.forename: Michiko
authors.initials: M
authors.lastname: Tsutsumiuchi
authors.forename: Meiko Hashimoto
authors.initials: MH
authors.lastname: Maeda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Uesaka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000328:Adult; D020324:Amnesia, Anterograde / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D020643:Anterior Thalamic Nuclei / Q000378:metabolism; D020520:Brain Infarction / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D002526:Cerebellar Diseases / Q000150:complications* / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000523:psychology; D002531:Cerebellum / Q000098:blood supply / Q000378:metabolism / Q000473:pathology; D005625:Frontal Lobe / Q000378:metabolism; D007839:Functional Laterality; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon
keywords: amnesia; cerebellar cognitive affective syndrome; cerebellar stroke; cerebellum; episodic memory