title: [Perianal and rectal ulcers due to abuse of paracetamol-codeine suppositories].
abstract: A 61-year-old woman presented with a progressive perianal ulcer which had developed 4 months ago. Upon further examination, another ulcer of the rectum was detected. Anorectal malignancies, viral infections or primary inflammatory bowel disease were not found. It could be demonstrated that the ulcers were induced by paracetamol and codeine suppositories. After discontinuation of these suppositories, the perianal ulcers healed almost completely within 3 weeks. The pathogenesis of paracetamol-induced ulcers is unknown. However, dose-dependent vasoconstriction is a possible explanation.
authors.affiliation: Klinik für Dermatologie, Allergologie und Phlebologie, Klinikum Bremerhaven Reinkenheide, Postbrookstr. 103, 27574, Bremerhaven, Deutschland, gunnar.wagner@klinikum-bremerhaven.de.
authors.forename: G
authors.initials: G
authors.lastname: Wagner
authors.forename: C
authors.initials: C
authors.lastname: Sand
authors.forename: M M
authors.initials: MM
authors.lastname: Sachse
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000506:poisoning*; D001004:Anus Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D003061:Codeine / Q000008:administration & dosage / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012002:Rectal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D012883:Skin Ulcer / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D019966:Substance-Related Disorders / Q000150:complications*; D013488:Suppositories
chemical_list: D013488:Suppositories; D000082:Acetaminophen; D003061:Codeine