title: Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastases using susceptibility-weighted imaging.
abstract: OBJECTIVE
  Conventional MRI is often difficult to distinguish between primary central nervous system lymphomas (PCNSLs), high-grade gliomas and brain metastases due to the similarity of their appearance. The aim of this study was to investigate whether the susceptibility-weighted imaging (SWI) has higher sensitivity than conventional MRI in detecting hemorrhage between PCNSLs, high-grade gliomas and brain metastases, and can be used to differentiate the diagnosis between these tumors.
  
  
  METHODS
  The number of lesions with hemorrhage was quantified by both the conventional MR imaging and SWI. The number of micro-hemorrhage and vessels within lesions were counted on SWI.
  
  
  RESULTS
  The detection rate of hemorrhage on SWI was significantly higher than that on the conventional MR imaging. The intralesional hemorrhagic burden and the number of the vessels within lesions detected by SWI were significantly higher in high-grade gliomas and brain metastases than those in PCNSLs. There was no significant difference in these two parameters between high-grade gliomas and brain metastases. The best predictor to differentiate PCNSLs from high-grade gliomas and brain metastases was intralesional vessel number that yielded the best ROC characteristics and highest classification accuracy.
  
  
  CONCLUSIONS
  SWI is useful in differentiating of PCNSLs from high-grade gliomas and brain metastases.
authors.affiliation: Department of Radiology, First Affiliated Hospital, Fujian Medical University Fuzhou, 350005, China.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Department of Radiology, First Affiliated Hospital, Fujian Medical University Fuzhou, 350005, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Xing
authors.affiliation: Department of Radiology, First Affiliated Hospital, Fujian Medical University Fuzhou, 350005, China.
authors.forename: Biying
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Medicine and UC San Diego Moores Cancer Center, University of California-San Diego La Jolla, California, USA.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Lin
authors.affiliation: Department of Radiology, First Affiliated Hospital, Fujian Medical University Fuzhou, 350005, China.
authors.forename: Dairong
authors.initials: D
authors.lastname: Cao
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D005910:Glioma / Q000150:complications / Q000473:pathology*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Brain metastases; differential diagnosis of intracranial malignancies; high-grade glioma; primary CNS lymphoma; susceptibility-weighted imaging