title: [Updates on Lifestyle-Related Diseases and Bone Metabolism. Mechanism of bone fragility in lifestyle-related disease at material level].
abstract: Lifestyle-related diseases such as diabetes, arteriosclerosis, chronic kidney disease, and chronic obstructive pulmonary disease (COPD) exhibit poor bone material properties induced by an increase of oxidative stress and excessive glycation. In this review, we described the role of oxidative stress in the quantitative and qualitative changes in collagen.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine, Japan.
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Saito
mesh_terms: D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism; D050723:Fractures, Bone / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008019:Life Style; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism
chemical_list: D003094:Collagen