title: Expression of tmp21 in normal adult human tissues.
abstract: TMP21, known as p23 protein, is one important member of the p24 protein families. The degradation of TMP21 is mediated by the ubiquitin-proteasome pathway, as with the other presenilin-associated γ-secretase complex members. NFAT plays a very important role in regulation of human TMP21 gene expression. Compared with the function of TMP21, the studies about the distribution of this protein in human tissues are limited. We collected 19 normal adult human tissues from a healthy adult man died in a traffic accident and did examination of all the tissues collected for ICH, western blot and RT-PCR. It was shown that the expression of TMP21 is at high levels in heart, liver, lung, kidney and adrenal gland; moderate levels in brain, pancreas, prostate gland, testicle, small intestine, colon, stomach, gall bladder, thyroid gland and trachea; low levels in skeletal muscle, skin and lymphonodus. TMP21 is widely existed in normal adult human tissues. The current study provided for the first time a comprehensive expression of TMP21 in normal adult human tissues. It will benefit on helping in the design and interpretation of future studies focused on expounding the function of TMP21.
authors.affiliation: Department of Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing, China ; Department of General Surgery, Yong Chuan Hospital of Chongqing Medical University Chongqing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Forensic Medicine, Chongqing Medical University Chongqing, China.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Hou
authors.affiliation: National Laboratory of Medical Genetics of China, Central South University Changsha, Hunan, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Xia
authors.affiliation: Townsend Family Laboratories, Department of Psychiatry, Brain Research Center, Graduate Program in Neuroscience, The University of British Columbia 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
authors.forename: Weihong
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Surgery, The First Affiliated Hospital of Chongqing Medical University Chongqing, China.
authors.forename: Shengchun
authors.initials: S
authors.lastname: Liu
keywords: RT-PCR; TMP21; human tissue; immunohistochemistry; western-blotting