title: Stromal cells as trend-setters for cells migrating into the lymph node.
abstract: Lymph node stromal cells are known to be immunorelevant during inflammation and tolerance. Differences between peripheral lymph nodes and mesenteric lymph nodes are important for an efficient and effective immune defense. Stromal cells were considered to be perfectly adapted to their draining area and not changeable concerning their expression pattern. Here we show that stromal cells can change their profile after isolation and transplantation into a different draining area. Subsequently, these newly organized lymph nodes are able to induce not only a region-specific but also an antigen-specific immune response. Thus, stromal cells are trend-setters for immune cells in producing a microenvironment that allows an optimized immune defense.
authors.affiliation: Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Buettner
authors.affiliation: Institute of Physiological Chemistry, Hannover Medical School, Hannover, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Dittrich-Breiholz
authors.affiliation: Institute of Transplant Immmunology, IFB-Tx, Hannover Medical School, Hannover, Germany.
authors.forename: C S
authors.initials: CS
authors.lastname: Falk
authors.affiliation: Institute of Infection Immunology, TWINCORE, Centre for Experimental and Clinical Infection Research (a joint venture between the Medical School Hannover (MHH) and the Helmholtz Centre for Infection Research (HZI)), Hannover, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Lochner
authors.affiliation: Institute of Laboratory Animal Science, Hannover Medical School, Hannover, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Smoczek
authors.affiliation: Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Menzel
authors.affiliation: Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Bornemann
authors.affiliation: Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Bode
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000235:genetics / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D060833:Cellular Microenvironment / Q000276:immunology*; D054426:Chemokine CXCL2 / Q000235:genetics / Q000276:immunology; D019743:Chemokines, CXC / Q000235:genetics / Q000276:immunology; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D017930:Genes, Reporter; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000276:immunology; D006706:Homeostasis / Q000276:immunology; D007108:Immune Tolerance; D020382:Interleukin-18 / Q000235:genetics / Q000276:immunology; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009088:Mucoproteins; D009928:Organ Specificity; D015398:Signal Transduction; D017154:Stromal Cells / Q000166:cytology / Q000276:immunology*
chemical_list: C517518:CXCL14 protein, mouse; D015815:Cell Adhesion Molecules; D054426:Chemokine CXCL2; D019743:Chemokines, CXC; C404915:Cxcl2 protein, mouse; D020382:Interleukin-18; D015850:Interleukin-6; C489082:Madcam1 protein, mouse; D009088:Mucoproteins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins; D000445:Aldehyde Oxidoreductases; C470579:RALDH2 protein, mouse