title: Platelet to lymphocyte ratio as a prognostic marker in primary percutaneous coronary intervention.
abstract: We assessed the prognostic value of the platelet to lymphocyte ratio (PLR) in primary percutaneous coronary intervention (pPCI). Patients (n = 440) with acute myocardial infarction (AMI) who underwent pPCI were divided into 2 groups: low PLR (<137) and high PLR (>137). "Thrombolysis In Myocardial Infarction" (TIMI) flow grades and Syntax scores (SXS) were calculated from initial angiograms. In-hospital mortality rate and cardiac adverse events were obtained from medical records. Patients with high PLR had more no-reflow, higher SXS and higher mortality rate (p < 0.001, p < 0.001 and p = 0.008, respectively). In receiver operating characteristic curve analysis, high PLR predicted development of no-reflow (specificity 71% and sensitivity 85%), SXS>22 (specificity 52% and sensitivity 61%) and adverse events (specificity 67% and sensitivity 63%). In multivariate regression analysis, PLR was an independent risk factor for no-reflow, SXS>22 and in-hospital adverse events. In addition to PLR, we present the relationship between mean platelet volume, red cell distribution width and neutrophil to lymphocyte ratio and no-reflow, SXS and in-hospital adverse events.
authors.affiliation: a Department of Cardiology , Bağcilar Education and Research Hospital , Istanbul , Turkey .
authors.forename: Burak
authors.initials: B
authors.lastname: Ayça
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Çelik
authors.forename: Yasin
authors.initials: Y
authors.lastname: Yüksel
authors.forename: Derya
authors.initials: D
authors.lastname: Öztürk
authors.forename: Fatih
authors.initials: F
authors.lastname: Tekiner
authors.forename: Şükrü
authors.initials: Ş
authors.lastname: Çetin
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Okuyan
authors.forename: Hakan
authors.initials: H
authors.lastname: Dinçkal M
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D005260:Female; D006760:Hospitalization; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000601:surgery; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010976:Platelet Count; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers
keywords: Mortality; no-reflow; platelet to lymphocyte ratio; primary percutaneous coronary intervention; syntax score