title: Second malignancies in Hodgkin's disease: A review of the literature and report of a case with a secondary Lennert's lymphoma.
abstract: A small percentage of patients treated for Hodgkin's disease are at risk of developing a second malignancy. The appearance of secondary malignancies such as leukemia, carcinoma or non-Hodgkin's lymphomas may be attributed to the mutagenic effects of chemotherapy and/or radiotherapy. Most secondary non-Hodgkin's lymphomas are of the B-cell type, but isolated cases were reportedly of a T-cell lineage. A review of the literature pertaining to the development of secondary peripheral T-cell lymphomas is presented along with the description of an additional case. The latter developed in the tonsil and was diagnosed as a Lennert's lymphoma (lymphoepithelioid T cell lymphoma)on histological and immunological grounds. This report also reviews the development of a of peripheral T-cell lymphoma described in patients following chemotherapy and/or radiotherapy for Hodgkin's disease.
authors.affiliation: Department of Diagnostics, University of the Western Cape, Tygerberg, South Africa.
authors.forename: Ernst Jg
authors.initials: EJ
authors.lastname: Norval
authors.affiliation: Department of Pathology, School of Oral Health Sciences, University of Limpopo, Limpopo, South Africa.
authors.forename: Erich J
authors.initials: EJ
authors.lastname: Raubenheimer
keywords: Hodgkin's disease; Lennert's lymphoma; peripheral T-cell lymphoma; second malignancies in Hodgkin's disease; secondary non-Hodgkin's lymphoma