title: A review of the use of Piper betel in oxidative stress disorders.
abstract: Increase in prevalence of disease related oxidative stress disorders have been on the rise in the entire world since the past decades. Significant positive effects with few antioxidant properties in the modern drugs pave for the alternative medicines in managing the disease. Piper betel (P. betel), a herb, is known to possess high anti-oxidant, anti-diabetic, anti-atherosclerosis, anti-hyperlipidemic, anti-cancer and neuroprotective property. This review focused on the effect of P. betel on diabetes mellitus, atherosclerosis and chronic kidney disease, Alzheimer's disease and breast cancer. P. betel proved to show positive effects with specific outcomes towards these diseases. Moreover, the promising effect of P. betel in vitro studies was also highlighted in the present review. It is believed that the findings obtained in this review will draw the attention of the medical professionals and general public towards P. betel and it will open the door for further detailed research.
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: A S
authors.initials: AS
authors.lastname: Nurul Zaidah
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: G
authors.initials: G
authors.lastname: Nur Amalina
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: Ema
authors.initials: E
authors.lastname: Muhammad Azree
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: S
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abd Aziz, 53000, Kuala Lumpur, Malaysia.
authors.forename: C T
authors.initials: CT
authors.lastname: Zar
mesh_terms: D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy / Q000379:methods; D031721:Piper betle; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts
keywords: anti-oxidant; herbs; oxidative stress disorders; piper betel