title: A mitochondria-targeted protonophoric uncoupler derived from fluorescein.
abstract: Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory 1, Moscow 119991, Russia. antonen@genebee.msu.ru.
authors.forename: Stepan S
authors.initials: SS
authors.lastname: Denisov
authors.forename: Elena A
authors.initials: EA
authors.lastname: Kotova
authors.forename: Egor Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: Artur A
authors.initials: AA
authors.lastname: Tikhonov
authors.forename: Dmitry B
authors.initials: DB
authors.lastname: Zorov
authors.forename: Galina A
authors.initials: GA
authors.lastname: Korshunova
authors.forename: Yuri N
authors.initials: YN
authors.lastname: Antonenko
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002462:Cell Membrane / Q000378:metabolism; D019793:Fluorescein / Q000737:chemistry / Q000494:pharmacology*; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D007684:Kidney Tubules / Q000166:cytology; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D011522:Protons; D051381:Rats
chemical_list: D005456:Fluorescent Dyes; D009943:Organophosphorus Compounds; D011522:Protons; D019793:Fluorescein