title: Indole alkaloids with new skeleton activating neural stem cells.
abstract: Alstoscholarisines A-E (1-5), five unprecedented monoterpenoid indole alkaloids with 6/5/6/6/6 fused-bridge rings, were isolated from Alstonia scholaris. They promoted adult neuronal stem cells (NSCs) proliferation significantly, in which the most active one (1) functioned from a concentration of 0.1 μg/mL in a dosage-dependent manner. Furthermore, 1 enhanced NSC sphere formation and neurogenic fate commitment through activation of a Wnt signaling pathway and promoted NSC differentiation but did not affect proliferation of neuroblastoma cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Cui-Ping
authors.initials: CP
authors.lastname: Yang
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Jiang
authors.forename: Xu-Jie
authors.initials: XJ
authors.lastname: Qin
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Liu
authors.forename: Qiu-Shuo
authors.initials: QS
authors.lastname: Shen
authors.forename: Yong-Bin
authors.initials: YB
authors.lastname: Chen
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D002454:Cell Differentiation; D049109:Cell Proliferation / Q000187:drug effects*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D026121:Indole Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D058953:Neural Stem Cells / Q000737:chemistry* / Q000166:cytology* / Q000378:metabolism; D018515:Plant Leaves; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D060449:Wnt Signaling Pathway / Q000187:drug effects / Q000502:physiology*
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D026121:Indole Alkaloids; D007211:Indoles; D046948:Secologanin Tryptamine Alkaloids; C588339:alistonitrine A; C559185:alstoscholarine