title: Anti-inflammatory activity of Guduchi Ghana (aqueous extract of Tinospora Cordifolia Miers.).
abstract: BACKGROUND
  Guduchi Ghana is one of the unique Ayuvedic classical preparation which is prepared from aqueous of extract of Guduchi (Tinospora cordifolia Miers.) stem. It is one of the frequently used drugs to treat the Madhumeha, Pandu, Kamala, Amlapitta, Grahani, Kustha, Jirna Jwara and Viswamjwara, Trishna, Shool, Yakritavikara, etc. Looking to these indications, in market most of the Pharma industries prepared Guduchi Ghana by applying the various extraction process.
  
  
  OBJECTIVE
  To evaluate comparative anti-inflammatory activity of classically prepared and market sample of Guduchi Ghana.
  
  
  METHODS
  Both samples were evaluated for anti-inflammatory activity using carrageenan induced paw edema model in rats. Animals were divided in three groups, having six animals in each. Group A received test drug, Group B received market sample at a dose of 50 mg/kg orally, while Group C (control group) received tap water.
  
  
  RESULTS
  Reduction in edema was observed in Group A and B at 3 h interval by 33.06% and 11.71% respectively. Group A showed significant effects (P < 0.05) in comparison to control group.
  
  
  CONCLUSIONS
  These experimental results have shown anti-inflammatory activity of Guduchi Ghana.
authors.affiliation: Department of Rasa Shastra and Bhaishajya Kalpana including drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India.
authors.forename: Biswajyoti
authors.initials: B
authors.lastname: Patgiri
authors.affiliation: Department of Rasa Shastra and Bhaishajya Kalpana, J.S. Ayurved College, Nadiad, Gujarat, India.
authors.forename: Bharti L
authors.initials: BL
authors.lastname: Umretia
authors.affiliation: Department of Rasa Shastra and Bhaishajya Kalpana, J.S. Ayurved College, Nadiad, Gujarat, India.
authors.forename: Pradip U
authors.initials: PU
authors.lastname: Vaishnav
authors.affiliation: Department of Rasa Shastra and Bhaishajya Kalpana including drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India.
authors.forename: Pradeep Kumar
authors.initials: PK
authors.lastname: Prajapati
authors.affiliation: Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors.forename: Vinay J
authors.initials: VJ
authors.lastname: Shukla
authors.affiliation: Research and Development, SDM College of Ayurveda, Kuthpady, Udupi, Karnataka, India.
authors.forename: B
authors.initials: B
authors.lastname: Ravishankar
keywords: Anti-inflammatory activity; Ghana Kalpana; Guduchi; Tinospora cordifolia; aqueous extract; carrageenan