title: Accelerated regeneration of skin injury by co-transplantation of mesenchymal stem cells from Wharton's jelly of the human umbilical cord mixed with microparticles.
abstract: This study was set to explore a new strategy for repairing skin wounds, co-transplantation of mesenchymal stem cells from Wharton's Jelly of the human umbilical cord (hUC-Wharton's jelly-MSCs) and microparticles. A mixture of hUC-Wharton's jelly-MSCs and microparticles was co-transplanted to 10-mm diameter, full-thickness, mid-dorsal, excisional skin wounds of mice. After 7, 14, and 21 days, the tissue sections were sampled for reconstruction analysis and histological examination. Our results showed that hUC-Wharton's jelly-MSCs possess the potentials for multi-directional differentiation. After co-transplantation, there was remarkable development of newborn skin and its appendages. Newly generated layers of epidermis, sebaceous glands, hair follicle, and sweat glands were observed. This promising innovative strategy could significantly increase the quality of repair and regeneration of skin after injuries.
authors.affiliation: Burns Department, Zhujing Hospital, Southern Medical University, Guangzhou, 510280, China.
authors.forename: Shengjun
authors.initials: S
authors.lastname: Shi
authors.forename: Siyuan
authors.initials: S
authors.lastname: Jia
authors.forename: Jingwen
authors.initials: J
authors.lastname: Liu
authors.forename: Guangping
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D055252:Cell-Derived Microparticles / Q000637:transplantation*; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000293:injuries*; D014945:Wound Healing