title: Dermabacter hominis: a usually daptomycin-resistant gram-positive organism infrequently isolated from human clinical samples.
abstract: During a 12-year period, Dermabacter hominis was isolated from 21 clinical samples belonging to 14 patients attending a tertiary hospital in León, Spain. Samples included blood cultures (14), peritoneal dialysis catheter exit sites (three), cutaneous abscesses (two), an infected vascular catheter (one) and a wound swab (one). Identification was made by API Coryne™ V2.0, Biolog™ GP2 and 16S rRNA gene amplification. Six febrile patients had positive blood cultures (one, two or three sets) and all of them were treated with teicoplanin (two patients), vancomycin, ampicillin plus gentamicin, amoxicillin/clavulanic acid and ciprofloxacin (one each). An additional patient with a single positive blood culture was not treated, the finding being considered non-significant. In the remaining seven patients the organism was isolated from a single specimen and three of them received antimicrobial treatment (ciprofloxacin, ceftriaxone plus vancomycin and amoxicillin/clavulanic acid). At least ten patients had several underlying diseases and conditions, and no direct mortality was observed in relation to the isolated organism. All isolates were susceptible to vancomycin, rifampin and linezolid. Resistance to other antibiotics varied: erythromycin (100%), clindamycin (78.5%), ciprofloxacin (21.4%) and gentamicin, quinupristin-dalfopristin, benzylpenicillin and imipenem 7.1% each. Thirteen isolates were highly resistant to daptomycin with MICs ranging from 8 to 48 (MIC90 = 32 mg/L); only one was daptomycin-sensitive (MIC = 0.19 mg/L).
authors.affiliation: Department of Clinical Microbiology, Complejo Asistencial Universitario de León, and Institute of Biomedicine (IBIOMED), University of León.
authors.forename: I
authors.initials: I
authors.lastname: Fernández-Natal
authors.affiliation: Service of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Sáez-Nieto
authors.affiliation: Service of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III Madrid, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Medina-Pascual
authors.affiliation: Institut für Genomforschung, CeBiTec, Universität Bielefeld Bielefeld, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Albersmeier
authors.affiliation: Service of Bacteriology, Centro Nacional de Microbiología, Instituto de Salud Carlos III Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Valdezate
authors.affiliation: Institut für Genomforschung, CeBiTec, Universität Bielefeld Bielefeld, Germany ; Department of Internal Medicine, Complejo Asistencial Universitario de León Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Guerra-Laso
authors.affiliation: Department of Clinical Microbiology, Complejo Asistencial Universitario de León, and Institute of Biomedicine (IBIOMED), University of León.
authors.forename: H
authors.initials: H
authors.lastname: Rodríguez
authors.affiliation: Department of Clinical Microbiology, Complejo Asistencial Universitario de León, and Institute of Biomedicine (IBIOMED), University of León.
authors.forename: T
authors.initials: T
authors.lastname: Marrodán
authors.affiliation: Department of Clinical Microbiology, Complejo Asistencial Universitario de León, and Institute of Biomedicine (IBIOMED), University of León.
authors.forename: T
authors.initials: T
authors.lastname: Parras
authors.affiliation: Institut für Genomforschung, CeBiTec, Universität Bielefeld Bielefeld, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Tauch
authors.affiliation: Public Health, School of Physiotherapy ONCE Madrid, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Soriano
keywords: Antimicrobial susceptibility; Dermabacter hominis; clinical relevance; daptomycin resistance; identification; isolation