title: The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis.
abstract: The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.
authors.affiliation: IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy. marco.genua@humanitasresearch.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Genua
authors.affiliation: Division of Translational Medicine, Research Branch, Sidra Medical & Research Center, Doha, Qatar. Srutella@sidra.org.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rutella
authors.affiliation: IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy. carmen.correale@humanitasresearch.it.
authors.forename: Carmen
authors.initials: C
authors.lastname: Correale
authors.affiliation: IBD Center, Humanitas Clinical and Research Hospital, Rozzano, Italy. sdanese@hotmail.com.
authors.forename: Silvio
authors.initials: S
authors.lastname: Danese
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000209:etiology* / Q000378:metabolism*; D008954:Models, Biological; D022423:Myeloid Cells / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011971:Receptors, Immunologic