title: Mechanisms underlying increased vascular smooth muscle contractility in the rabbit basilar artery following subarachnoid hemorrhage.
abstract: Increased vascular contractility plays an important role in the development of cerebral vasospasm following subarachnoid hemorrhage (SAH). Here, we summarize our current knowledge regarding molecular mechanisms that contribute to increased smooth muscle contractility of rabbit basilar artery following SAH. Our studies demonstrated that upregulation of receptor expression, impairment of feedback regulation of receptor activity, and enhancement of myofilament Ca²⁺ sensitization might lead to increased smooth muscle contractility following SAH.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan, ykikkawa@ns.med.kyushu-u.ac.jp.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kikkawa
authors.forename: Katsuharu
authors.initials: K
authors.lastname: Kameda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Matsuo
authors.forename: Ryota
authors.initials: R
authors.lastname: Kurogi
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamizo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Mizoguchi
authors.forename: Tomio
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D014661:Vasoconstriction / Q000502:physiology*; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*