title: Relationship among nocturnal sleep deficit, excess weight and metabolic alterations in adolescents.
abstract: Sleep modulates neuroendocrine function and metabolism; therefore, changes in sleep duration may lead to developing obesity during adolescence.
  
  
  
  To assess the possible association among nocturnal sleep duration, the presence of overweight and metabolic alterations in a group of adolescents.
  
  
  
  Cross-sectional, analytical study conducted at a school in Valencia, Venezuela, during the 2012-2013 school year. Participants were 12 to 17 year-old adolescents. A survey on nocturnal sleep duration was administered; weight, height and waist circumference were recorded; and glycemia, lipid profile and insulinemia levels were measured. Body mass index and the homeostasis model assessment of insulin resistance (HOMA-IR) index were calculated.
  
  
  
  Ninety adolescents were included. Compared to the group with normal weight, adolescents with excessive weight had, in average, fewer sleep hours Sundays through Thursdays (p < 0.05) and a higher rate of sleep deficit and sleep debt (p < 0.05). Low HDL cholesterol and insulin resistance was significantly associated with sleep debt (p < 0.05). Among adolescents with sleep debt, the risk of having excess weight was 2.70 times higher (95% CI= 1.09-6.72; p= 0.032) regardless of age, gender, sexual maturity, sleep deficit Sundays through Thursdays, and history of cardiovascular disease and diabetes in first-degree relatives.
  
  
  
  Nocturnal sleep deficit and sleep debt were significantly associated with excess weight and metabolic alterations related to a high cardiometabolic risk.
authors.affiliation: Instituto de Investigaciones en Nutrición.
authors.forename: Nelina
authors.initials: N
authors.lastname: Ruiz
authors.affiliation: Departamento de Morfofisiopatología de la Escuela de Bioanálisis, Facultad de Ciencias de la Salud, Universidad de Carabobo.
authors.forename: Airam
authors.initials: A
authors.lastname: Rangel
authors.affiliation: Departamento de Morfofisiopatología de la Escuela de Bioanálisis, Facultad de Ciencias de la Salud, Universidad de Carabobo.
authors.forename: Carla
authors.initials: C
authors.lastname: Rodríguez
authors.affiliation: Departamento de Morfofisiopatología de la Escuela de Bioanálisis, Facultad de Ciencias de la Salud, Universidad de Carabobo.
authors.forename: Lisette
authors.initials: L
authors.lastname: Rodríguez
authors.affiliation: Departamento de Morfofisiopatología de la Escuela de Bioanálisis, Facultad de Ciencias de la Salud, Universidad de Carabobo.
authors.forename: Valeria
authors.initials: V
authors.lastname: Rodríguez
mesh_terms: D000293:Adolescent; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D050177:Overweight / Q000453:epidemiology* / Q000378:metabolism*; D012890:Sleep; D013997:Time Factors; D014687:Venezuela