title: Effects of estradiol valerate and dienogest on quality of life and sexual function according to age.
abstract: This is an observational study on 102 women aged 25-45 years to evaluate if the E2V/DNG pill has any impact on quality of life (QoL) and sexual function (FSF). Thirty-nine women were younger than 35 years (group A), and 63 women were 35 years old or older (group B). At baseline and after 6 months, patients received the Italian validated version of the Short Form-36 questionnaire and the Italian validated version of the Female Sexual Function Index questionnaire. Group A showed an overall higher perception in all QoL scores at baseline and after 6-months (p < 0.05). E2V/DNG treatment did not exert any significant effect on QoL perception in group A apart from an increase in the GH domain (general health). In group B we observed a significant improvement both in GH and in VT (vitality) scores. We found a significant reduction in "lubrication" after 6 months both in group A and B (p < 0.01) and a significant improvement in "satisfaction" and "pain" scores in group A and in "desire", "satisfaction" and "total" score in group B (p < 0.01). The E2V/DNG pill is associated with a significant improvement of GH and VT and with an improvement in FSF with no difference between age groups.
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Costantino
authors.initials: C
authors.lastname: Di Carlo
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Virginia
authors.initials: V
authors.lastname: Gargano
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Nicoletta
authors.initials: N
authors.lastname: De Rosa
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Giovanni Antonio
authors.initials: GA
authors.lastname: Tommaselli
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Sparice
authors.affiliation: a Department of Obstetrics and Gynecology, University of Naples Naples Italy.
authors.forename: Carmine
authors.initials: C
authors.lastname: Nappi
mesh_terms: D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology / Q000627:therapeutic use*; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007989:Libido / Q000187:drug effects; D008875:Middle Aged; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D010549:Personal Satisfaction; D011788:Quality of Life / Q000523:psychology*; D012725:Sexual Behavior / Q000187:drug effects* / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D003277:Contraceptives, Oral, Combined; C023635:dienogest; D004958:Estradiol; D009277:Nandrolone
keywords: Contraception; dienogest; lifestyle; natural-oestrogen; sexuality