title: Unexplained hemolysis in patients undergoing ECMO: beware of hypertriglyceridemia.
abstract: Hemolysis is a common complication of extracorporeal membrane oxygenation (ECMO) support and is associated with increased mortality. Frequent monitoring of markers of hemolysis is performed at ECMO centers. We report two cases of spurious hemolysis caused by hypertriglyceridemia in patients undergoing ECMO support. Critically ill patients, including those receiving ECMO, may be at risk of developing medication-induced hypertriglyceridemia. The interference of lipids with the measurement of plasma free hemoglobin, a marker of hemolysis, should be recognized. Our cases highlight the importance of investigating hypertriglyceridemia as part of the assessment of unexplained hemolysis in patients supported with ECMO.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Alabama, USA.
authors.forename: A
authors.initials: A
authors.lastname: Venado
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Alabama, USA.
authors.forename: K
authors.initials: K
authors.lastname: Wille
authors.affiliation: Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Alabama, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Belott
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, Alabama, USA diaze@uab.edu.
authors.forename: E
authors.initials: E
authors.lastname: Diaz-Guzman
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D006454:Hemoglobins / Q000378:metabolism*; D006461:Hemolysis; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D008297:Male
chemical_list: D015415:Biomarkers; D006454:Hemoglobins
keywords: ECMO; hemolysis; hypertriglyceridemia; propofol; sirolimus