title: Suppression of nanoparticle cytotoxicity approaching in vivo serum concentrations: limitations of in vitro testing for nanosafety.
abstract: Nanomaterials challenge paradigms of in vitro testing because unlike molecular species, biomolecules in the dispersion medium modulate their interactions with cells. Exposing cells to nanoparticles known to cause cell death, we observed cytotoxicity suppression by increasing the amount of serum in the dispersion medium towards in vivo-relevant conditions.
authors.affiliation: Centre for BioNano Interactions, School of Chemistry and Chemical Biology and Conway Institute for Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland. kenneth.a.dawson@cbni.ucd.ie christoffer.aberg@cbni.ucd.ie.
authors.forename: Jong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Anna
authors.initials: A
authors.lastname: Salvati
authors.forename: Christoffer
authors.initials: C
authors.lastname: Åberg
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Dawson
mesh_terms: D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D006801:Humans; D053758:Nanoparticles / Q000009:adverse effects* / Q000737:chemistry; D011137:Polystyrenes / Q000009:adverse effects* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D011137:Polystyrenes