title: [Cardioprotective properties of new glutamic acid derivative under stress conditions].
abstract: The effect of new glutamic acid derivative on the cardiac ino- and chronotropic functions has been studied in experiments on rats exposed to 24-hour immobilization-and-pain stress. It is established that glutamic acid derivative RGPU-238 (glufimet) at a dose of 28.7 mg/kg increases the increment of myocardial contractility and relaxation rates and left ventricular pressure in stress-tested animals by 13 1,1, 72.4, and 118.6%, respectively, as compared to the control group during the test for adrenoreactivity. Compound RGPU-238 increases the increment of the maximum intensity of myocardium functioning by 196.5 % at 30 sec of isometric workload as compared to the control group. The cardioprotective effect of compound RGPU-238 is 1.5 - 2 times higher than that of the reference drug phenibut.
authors.forename: V N
authors.initials: VN
authors.lastname: Perfilova
authors.forename: N V
authors.initials: NV
authors.lastname: Sadikova
authors.forename: V M
authors.initials: VM
authors.lastname: Berestovitskaia
authors.forename: O S
authors.initials: OS
authors.lastname: Vasil'eva
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004334:Drug Administration Schedule; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D007103:Immobilization; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology / Q000517:prevention & control; D051381:Rats; D013312:Stress, Physiological; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D002316:Cardiotonic Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid