title: Genetic variations rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population.
abstract: Genome-wide association studies (GWAS) have identified a number of genetic variants associated with risk of bladder cancer in populations of European descent. Here, we assessed association of two of these variants, rs11892031 (2q37.1 region) and rs401681 (5p15.33 region) in a Chinese case-control study, which included 367 bladder cancer cases and 420 controls. We found that the AC genotype of rs11892031 was associated with remarkably decreased risk of bladder cancer (adjusted odds ratio (OR), 0.27; 95% confidence interval (CI), 0.09-0.81; p=0.019), compared with the AA genotype of rs11892031; and that CT/CC genotypes of rs401681 were associated with significantly increased risk of bladder cancer (adjusted OR, 1.79; 95% CI, 1.10-2.91; p=0.02), compared with the TT genotype of rs401681. We further conducted stratification analysis to examine the correlation between single nucleotide polymorphism (SNP) rs11892031/rs401681 and tumor grade/stage. Results showed that heterogeneity in ORs of tumor categories was not significant for either rs11892031 or rs401681 (p>0.05), indicating that the two SNPs seemingly do not associate with tumor grade and stage of bladder cancer in our study population. The present study suggests that the SNPs rs11892031 and rs401681 are associated with bladder cancer risk in a Chinese population. Future analyses will be conducted with more participants recruited in a case-control study.
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. xielinguo@tijmu.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Tianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. sungravel@139.com.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. chentao@tmu.edu.cn.
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. hhllove2004@163.com.
authors.forename: Hailong
authors.initials: H
authors.lastname: Hu
authors.affiliation: Tianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. wanqinxie@126.com.
authors.forename: Wanqin
authors.initials: W
authors.lastname: Xie
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. qiaozh2003@126.com.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Qiao
authors.affiliation: Tianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University, Tianjin 300211, China. dingnalove2003@126.com.
authors.forename: Na
authors.initials: N
authors.lastname: Ding
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. xielinguo@126.com.
authors.forename: Linguo
authors.initials: L
authors.lastname: Xie
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. lishengwudi1250@163.com.
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. wangwl1989@126.com.
authors.forename: Wenlong
authors.initials: W
authors.lastname: Wang
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. xc2772@163.com.
authors.forename: Chen
authors.initials: C
authors.lastname: Xing
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. wangyih1988@126.com.
authors.forename: Yihan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. yunkaiqie@sohu.com.
authors.forename: Yunkai
authors.initials: Y
authors.lastname: Qie
authors.affiliation: Department of Urology, the Second Hospital of Tianjin Medical University, Pingjiang Road 23, Hexi District, Tianjin 300211, China. wujygc2003@163.com.
authors.forename: Changli
authors.initials: C
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000473:pathology