title: [Influence of thoracoscopic surgery on inflammatory reaction of the body   for early peripheral lung cancer patients].
abstract: OBJECTIVE
  It has been proven that video assited thoracoscopic surgery (VATS) achieved the same survival rates compared with traditional open chest operation in the treatment of early stage of lung cancer. but it is unclear if there is any difference of body inflammatory reaction between the two operation. The aim of this study is to investigate the changes of inflammatory state of thoracoscopic radical lobectomy in early peripheral lung cancer patients.
  
  
  METHODS
  Senventy-one early peripheral lung cancer patients who have underwent radical lobectomy were divided into two groups based on the different operation method. The VATS group was treated by thoracoscopic lobectomy. The thoracotomy group was treated by traditional thoracotomy. Then the level of serum C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-10 at 1-day before operation and 3-day, 7-day postoperation were measured and compared between the two groups.
  
  
  RESULTS
  No significant difference was found in the level of serum CRP, TNF-α, IL-6 and IL-10 before operation. Compared to the thoracotomy group, the level of serum CRP, TNF-α, IL-6 and IL-10 in the VATS group were significantly lower after operation.
  
  
  CONCLUSIONS
  Compared with thoracotomy lobectomy, thoracoscopic lobectomy for early peripheral lung cancer patients is associated with lower inflammatory responses .
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Honglin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Jinghao
authors.initials: J
authors.lastname: Liu
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Song
authors.initials: S
authors.lastname: Xu
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Gaoyang
authors.initials: G
authors.lastname: Lin
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.affiliation: Tianjin Medical University General Hospital of Lung Cancer Surgery, Tianjin 300052, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000097:blood* / Q000209:etiology*; D020775:Thoracic Surgery, Video-Assisted / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D002097:C-Reactive Protein