title: Epidemiology of hepatitis E virus in China: results from the Third National Viral Hepatitis Prevalence Survey, 2005-2006.
abstract: In China, hepatitis E virus (HEV) is prevalent and causes disease, but its epidemiological profile is not well understood. We used a commercial enzyme-linked immunosorbent assay to detect total antibodies to hepatitis E virus in 15,862 serum samples collected during the Third National Viral Hepatitis Prevalence Survey. The results were analyzed to calculate estimates of HEV seroprevalence and to examine the effects of some putative risk factors. The seroprevalence of HEV in the general Chinese population during the period from 2005 through 2006 was 23.46% (95% confidence interval [CI], 18.41%-28.50%). The farming population, the age group of 15-60 year olds, and those living in the Midwest or Mideast region and in Xinjiang province had the highest seroprevalence estimates. The prevalence of HEV is high in China. The seroprevalence rate of HEV shows an unbalanced distribution among areas with different geographic location and economic development levels. The characteristics of the distribution associated may be due to the route of HEV transmission (via contaminated water or animal reservoirs). Within the same region, the seroprevalence of HEV is generally increased with age.
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Jia
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Cao
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ruiguang
authors.initials: R
authors.lastname: Tian
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xinying
authors.initials: X
authors.lastname: Wang
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Qiudong
authors.initials: Q
authors.lastname: Su
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Zhou
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Fuqiang
authors.initials: F
authors.lastname: Cui
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liang
authors.affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Shengli
authors.initials: S
authors.lastname: Bi
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003625:Data Collection; D016751:Hepatitis E / Q000097:blood / Q000453:epidemiology; D016752:Hepatitis E virus / Q000276:immunology / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral