title: Analytical tools and current challenges in the modern era of neuroepigenomics.
abstract: Over the past decade, rapid advances in epigenomics research have extensively characterized critical roles for chromatin regulatory events during normal periods of eukaryotic cell development and plasticity, as well as part of aberrant processes implicated in human disease. Application of such approaches to studies of the CNS, however, is more recent. Here we provide a comprehensive overview of available tools for analyzing neuroepigenomics data, as well as a discussion of pending challenges specific to the field of neuroscience. Integration of numerous unbiased genome-wide and proteomic approaches will be necessary to fully understand the neuroepigenome and the extraordinarily complex nature of the human brain. This will be critical to the development of future diagnostic and therapeutic strategies aimed at alleviating the vast array of heterogeneous and genetically distinct disorders of the CNS.
authors.affiliation: 1] Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Maze
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Li
authors.identifier: 0000000251902851
authors.initials: L
authors.lastname: Shen
authors.affiliation: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Garcia
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Ningyi
authors.initials: N
authors.lastname: Shao
authors.affiliation: 1] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Mitchell
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: HaoSheng
authors.initials: H
authors.lastname: Sun
authors.affiliation: 1] Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Schahram
authors.initials: S
authors.lastname: Akbarian
authors.affiliation: Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York, USA.
authors.forename: C David
authors.initials: CD
authors.lastname: Allis
authors.affiliation: Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Nestler
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D002843:Chromatin; D057890:Epigenomics; D055106:Genome-Wide Association Study; D006801:Humans; D040901:Proteomics; D013223:Statistics as Topic
chemical_list: D002843:Chromatin