title: PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.
abstract: The discovery of mutations in genes encoding protein kinase PTEN-induced kinase 1 (PINK1) and E3 ubiquitin ligase Parkin in familial Parkinson's disease and their association with mitochondria provides compelling evidence that mitochondrial dysfunction is a major contributor to neurodegeneration in Parkinson's disease. In recent years, tremendous progress has been made in the understanding of how PINK1 and Parkin enzymes are regulated and how they influence downstream mitochondrial signalling processes. We provide a critical overview of the key advances in the field and also discuss the outstanding questions, including novel ways in which this knowledge could be exploited to develop therapies against Parkinson's disease.
authors.affiliation: MRC Protein Phosphorylation and Ubiquitylation Unit, University of Dundee, UK.
authors.forename: Agne
authors.initials: A
authors.lastname: Kazlauskaite
authors.forename: Miratul M K
authors.initials: MM
authors.lastname: Muqit
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000473:pathology; D009154:Mutation; D009410:Nerve Degeneration / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D025801:Ubiquitin / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein
keywords: PINK1; Parkinson's disease; kinase; mitochondria; parkin; ubiquitin