title: Overall and abdominal adiposity and premenopausal breast cancer risk among hispanic women: the breast cancer health disparities study.
abstract: BACKGROUND
  Few studies in Hispanic women have examined the relation between adult body size and risk of premenopausal breast cancer defined by hormone receptor status.
  
  
  METHODS
  The Breast Cancer Health Disparities Study pooled interview and anthropometric data from two large U.S. population-based case-control studies. We examined associations of overall and abdominal adiposity with risk of estrogen receptor- and progesterone receptor-positive (ER(+)PR(+)) and -negative (ER(-)PR(-)) breast cancer in Hispanic and non-Hispanic White (NHW) women, calculating ORs and 95% confidence intervals.
  
  
  RESULTS
  Among Hispanics, risk of ER(+)PR(+) breast cancer was inversely associated with measures of overall adiposity, including young-adult and current body mass index (BMI). Risk was substantially reduced among those with high (above the median) young-adult BMI and current overweight or obesity. The findings for overall adiposity were similar for Hispanics and NHWs. In the subset of Hispanics with data on genetic ancestry, inverse associations of current BMI, and weight gain with ER(+)PR(+) breast cancer were limited to those with lower Indigenous American ancestry. For ER(-)PR(-) breast cancer, height was associated with increased risk, and young-adult BMI was associated with reduced risk. For all breast cancers combined, positive associations were seen for waist circumference, waist-to-hip ratio, and waist-to-height ratio in Hispanic women only.
  
  
  CONCLUSIONS
  Our findings of body size associations with specific breast cancer subtypes among premenopausal Hispanic women were similar to those reported for NHW women.
  
  
  CONCLUSIONS
  Adiposity throughout the premenopausal years has a major influence on breast cancer risk in Hispanic women.
authors.affiliation: Cancer Prevention Institute of California, Fremont, California. Division of Epidemiology, Department of Health Research and Policy and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California. Esther.John@cpic.org.
authors.forename: Esther M
authors.initials: EM
authors.lastname: John
authors.affiliation: Cancer Prevention Institute of California, Fremont, California.
authors.forename: Meera
authors.initials: M
authors.lastname: Sangaramoorthy
authors.affiliation: Department of Biology, University of Colorado at Colorado Springs, Colorado Springs, Colorado.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Hines
authors.affiliation: Department of Preventive Medicine, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Stern
authors.affiliation: Department of Epidemiology and Population Health, School of Public Health and Information Sciences, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky.
authors.forename: Kathy B
authors.initials: KB
authors.lastname: Baumgartner
authors.affiliation: Moffitt Cancer Center, Cancer Prevention and Control, Tampa, Florida.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.affiliation: Department of Medicine, University of Utah, Salt Lake City, Utah.
authors.forename: Roger K
authors.initials: RK
authors.lastname: Wolff
authors.affiliation: Department of Medicine, University of Utah, Salt Lake City, Utah.
authors.forename: Martha L
authors.initials: ML
authors.lastname: Slattery
mesh_terms: D050154:Adiposity / Q000502:physiology*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D054625:Healthcare Disparities; D006630:Hispanic or Latino; D006801:Humans; D017697:Premenopause; D012307:Risk Factors; D055105:Waist Circumference / Q000502:physiology*