title: Antiarrhythmic effect of uridine and uridine-5'-monophosphate in acute myocardial ischemia.
abstract: Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate. The drugs decreased lactate and restored reserves of glycogen and creatine phosphate depleted by ischemia. Uridine and uridine-5'-monophosphate significantly decreased the severity of ventricular arrhythmias. Both drugs reduced the incidence and duration of fibrillation. Uridine -5'-monophosphate demonstrated most pronounced antifibrillatory effectiveness. We hypothesize that the antiarrhythmic effect of the drugs is determined by their capacity to activate energy metabolism.
authors.affiliation: Department of Neuropharmacology, Research Institute of Experimental Medicine, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia.
authors.forename: V V
authors.initials: VV
authors.lastname: Bul'on
authors.forename: I B
authors.initials: IB
authors.lastname: Krylova
authors.forename: E N
authors.initials: EN
authors.lastname: Selina
authors.forename: O M
authors.initials: OM
authors.lastname: Rodionova
authors.forename: N R
authors.initials: NR
authors.lastname: Evdokimova
authors.forename: N S
authors.initials: NS
authors.lastname: Sapronov
authors.forename: G D
authors.initials: GD
authors.lastname: Mironova
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology; D003331:Coronary Vessels / Q000601:surgery; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D006003:Glycogen / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D008026:Ligation; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications* / Q000378:metabolism; D010725:Phosphocreatine / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D014529:Uridine / Q000494:pharmacology*; D014542:Uridine Monophosphate / Q000494:pharmacology*
chemical_list: D010725:Phosphocreatine; D019344:Lactic Acid; D006003:Glycogen; D014542:Uridine Monophosphate; D014529:Uridine