title: The close correlation between heparanase and COX-2 expression in lymphangiogenesis of cervical cancer.
abstract: Recent observations indicate the vital role of heparanase in tumor lymphangiogenesis. Moreover, heparanase is involved in angiogenesis in esophageal cancer through induction of COX-2. However, it is unclear whether heparanase is also associated with COX-2 in lymphangiogenesis of cervical cancer. In this study, heparanase, COX-2 and VEGF-C expression were examined in 80 cervical cancer cases by immunohistochemical staining. We also studied the correlation of heparanase and COX-2 expression with lymphangiogenesis of cervical cancer quantified as lymphatic vessel density. Our results showed that expressions of heparanase and COX-2 were associated with lymphangiogenesis of cervical cancer. Furthermore, a significant correlation was found between the expression of heparanase and COX-2 (P < 0.0001). Heparanase is positively correlated with expressions of COX-2 and VEGF-C. These findings revealed that heparanase may play important function in lymphangiogenesis of cervical cancer via the regulation of COX-2 expression.
authors.affiliation: Department of Pathology, Guangdong Medical College, Dongguan, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zeng
authors.forename: Lili
authors.initials: L
authors.lastname: Chen
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yang
authors.forename: Shijun
authors.initials: S
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology*; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism; D000099175:Heparanase
chemical_list: D051546:Cyclooxygenase 2; D005966:Glucuronidase; D042582:Vascular Endothelial Growth Factor C; D000099175:Heparanase; C496540:PTGS2 protein, human