title: Limb hypoplasia resulting from intrauterine infection with herpes simplex virus: a case report.
abstract: Intrauterine infection with herpes simplex virus, although very rare, has devastating effects on multiple organ systems in the fetus and can lead to in utero fetal demise. Neonates born following intrauterine herpes simplex virus infection commonly manifest with cutaneous lesions, ocular damage and/or brain abnormalities. We describe the case of a dichorionic, diamniotic twin gestation complicated by intrauterine herpes simplex virus infection. This infection led to the fetal demise of twin A and a very uncommon presentation of limb hypoplasia in twin B.
authors.affiliation: Division of Neonatology, Nemours at Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Carola
authors.affiliation: Division of Neonatology, Nemours at Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Skibo
authors.affiliation: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Cannon
authors.affiliation: Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Cam
authors.affiliation: 1] Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA [2] Department of Pediatric Dermatology, Nemours/A.I. Dupont Hospital for Children, Wilmington, DE, USA.
authors.forename: P
authors.initials: P
authors.lastname: Hyde
authors.affiliation: Division of Neonatology, Nemours at Thomas Jefferson University, Philadelphia, PA, USA.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Aghai
mesh_terms: D001132:Arm / Q000002:abnormalities*; D002821:Chorioamnionitis / Q000821:virology; D004200:Diseases in Twins / Q000151:congenital* / Q000821:virology; D005260:Female; D005313:Fetal Death; D005317:Fetal Growth Retardation; D006561:Herpes Simplex / Q000150:complications*; D018258:Herpesvirus 2, Human; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D038062:Upper Extremity Deformities, Congenital / Q000821:virology*; D055815:Young Adult