title: Perspectives in Pediatric Pathology, Chapter 21. Testicular Pathology in Heritable Metabolic Disease.
abstract: Inborn errors of metabolism have wide and profound effects in many or all organs, and especially so in those with endocrine functions. The testes are greatly affected by systemic metabolic disorders, leading to specific histological findings that generally reveal the nature of the underlying disorder. Here we describe the main testicular changes seen in the setting of metabolic disease.
authors.affiliation: 1 Department of Pathology, Hospital La Paz, Universidad Autónoma de Madrid, Calle Arzobispo Morcillo No. 2, Madrid 28029, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Nistal
authors.affiliation: 2 Department of Cell Biology, Universidad de Alcala, Madrid, Spain.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Paniagua
authors.affiliation: 1 Department of Pathology, Hospital La Paz, Universidad Autónoma de Madrid, Calle Arzobispo Morcillo No. 2, Madrid 28029, Spain.
authors.forename: Pilar
authors.initials: P
authors.lastname: González-Peramato
authors.affiliation: 3 Department of Pathology, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, One Children's Hospital Drive, 4401 Penn Avenue, Pittsburgh, PA 15224, USA.
authors.forename: Miguel
authors.initials: M
authors.lastname: Reyes-Múgica
mesh_terms: D006801:Humans; D008297:Male; D008661:Metabolism, Inborn Errors / Q000150:complications* / Q000473:pathology*; D013733:Testicular Diseases / Q000209:etiology* / Q000473:pathology*; D013737:Testis / Q000473:pathology*
keywords: testicular lysosomal disease; testicular metabolic disease; testicular mitochondrial disease; testicular storage disease