title: Pulmonary effects of i.v. injection of crushed oral tablets: "excipient lung disease".
abstract: OBJECTIVE
  When crushed oral tablets are injected i.v., their filler material (excipient) can induce a potentially fatal foreign-body reaction in pulmonary arterioles, presenting as dyspnea and pulmonary hypertension with centrilobular nodules on CT. We will describe the imaging and pathologic features of "excipient lung disease."
  
  
  CONCLUSIONS
  The radiologist has a critical role in recognizing and reporting excipient lung disease because the referring clinician may be unaware of the patient's i.v. drug abuse.
authors.affiliation: 1 Department of Radiology, University of Washington, 1959 NE Pacific St, Box 357115, Seattle, WA 98195.
authors.forename: Vicky T
authors.initials: VT
authors.lastname: Nguyen
authors.forename: Elaine S
authors.initials: ES
authors.lastname: Chan
authors.forename: Shinn-Huey S
authors.initials: SH
authors.lastname: Chou
authors.forename: J David
authors.initials: JD
authors.lastname: Godwin
authors.forename: Corinne L
authors.initials: CL
authors.lastname: Fligner
authors.forename: Rodney A
authors.initials: RA
authors.lastname: Schmidt
authors.forename: Sudhakar N J
authors.initials: SN
authors.lastname: Pipavath
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005079:Excipients / Q000506:poisoning*; D005260:Female; D005548:Foreign-Body Migration / Q000000981:diagnostic imaging* / Q000209:etiology*; D006801:Humans; D007275:Injections, Intravenous; D055370:Lung Injury / Q000000981:diagnostic imaging* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D015819:Substance Abuse, Intravenous / Q000150:complications*
chemical_list: D005079:Excipients
keywords: centrilobular nodules; drug abuse; excipient; microcrystalline cellulose; oral tablet; pulmonary arterial hypertension; talc