title: Migratory dynamic kinetic resolution of carbocyclic allylic alcohols.
abstract: A novel migratory dynamic kinetic resolution based on the interplay between an enzyme acylation catalyst and a heterogeneous Brønsted acid as an isomerization/racemization catalyst gives rise to carbocyclic allylic esters with excellent stereoselectivity from readily available tertiary carbinols. An easy-to-use teabag setup combining resin-bound catalysts, a biphasic isooctane-water solvent system, and a highly lipophilic acyl donor efficiently suppresses side reactions and allows for the preparation of functionalized carbocyclic building blocks in high yields and optical purity.
authors.affiliation: Department für Chemie, Universität zu Köln , 50939 Cologne, Germany.
authors.forename: Chicco
authors.initials: C
authors.lastname: Manzuna Sapu
authors.forename: Tamás
authors.initials: T
authors.lastname: Görbe
authors.forename: Richard
authors.initials: R
authors.lastname: Lihammar
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
authors.forename: Jan
authors.initials: J
authors.lastname: Deska