title: Genetic analysis of haplotype data for 23 Y-chromosome short tandem repeat loci in the Turkish population recently settled in Sarajevo, Bosnia and Herzegovina.
abstract: OBJECTIVE
  To explore the distribution and polymorphisms of 23 short tandem repeat (STR) loci on the Y chromosome in the Turkish population recently settled in Sarajevo, Bosnia and Herzegovina and to investigate its genetic relationships with the homeland Turkish population and neighboring populations.
  
  
  METHODS
  This study included 100 healthy unrelated male individuals from the Turkish population living in Sarajevo. Buccal swab samples were collected as a DNA source. Genomic DNA was extracted using the salting out method and amplification was performed using PowerPlex Y 23 amplification kit. The studied population was compared to other populations using pairwise genetic distances, which were represented with a multi-dimensional scaling plot.
  
  
  RESULTS
  Haplotype and allele frequencies of the sample population were calculated and the results showed that all 100 samples had unique haplotypes. The most polymorphic locus was DYS458, and the least polymorphic DYS391. The observed haplotype diversity was 1.0000 ± 0.0014, with a discrimination capacity of 1.00 and the match probability of 0.01. Rst values showed that our sample population was closely related in both dimensions to the Lebanese and Iraqi populations, while it was more distant from Bosnian, Croatian, and Macedonian populations.
  
  
  CONCLUSIONS
  Turkish population residing in Sarajevo could be observed as a representative Turkish population, since our results were consistent with those previously published for the homeland Turkish population. Also, this study once again proved that geographically close populations were genetically more related to each other.
authors.affiliation: Serkan Dogan, International Burch University, Department of Genetics and Bioengineering, Francuske revolucije bb, Ilidža, Sarajevo, Bosnia and Herzegovina, serkan.dogan@ibu.edu.ba.
authors.forename: Serkan
authors.initials: S
authors.lastname: Dogan
authors.forename: Dragan
authors.initials: D
authors.lastname: Primorac
authors.forename: Damir
authors.initials: D
authors.lastname: Marjanović
mesh_terms: D017522:Bosnia and Herzegovina / Q000453:epidemiology; D041322:Chromosomes, Human, Y / Q000235:genetics*; D005784:Gene Amplification; D005787:Gene Frequency; D005820:Genetic Testing; D005828:Genetics, Population; D060005:Genotyping Techniques; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey / Q000208:ethnology