title: Synergistic catalysis: enantioselective addition of alkylbenzoxazoles to enals.
abstract: A novel catalytic enantioselective methodology based on synergistic catalysis is reported. The strategy involves: 1) the metal-Lewis-acid activation of alkylazaarenes, and 2) the secondary-amine activation of enals. Consequently, highly functionalized chiral alkylazaarenes were obtained in good yields and with reasonable stereoselectivity.
authors.affiliation: Faculty of Natural and Environmental Sciences, University of Southampton, Highfield Campus, Southampton, SO17 1BJ (UK) www.riosresearchgroup.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Meazza
authors.forename: Victor
authors.initials: V
authors.lastname: Ceban
authors.forename: Mateusz B
authors.initials: MB
authors.lastname: Pitak
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Coles
authors.forename: Ramon
authors.initials: R
authors.lastname: Rios
keywords: Michael addition; alkyl azaarenes; iminium catalysis; palladium; synergistic catalysis