title: Hormone-dependent changes in female urinary proteome.
abstract: Human urine represents a good source for proteomic research for clinically related studies as it can be collected and processed easily and can give information about kidney-related mechanisms. Little is known about the urinary proteomic changes resulting from physiological (normal), pathological, or environmental variations, and there are few reports on hormone-related modifications of urine proteome. In our study, we highlighted the variations of urinary proteins associated with menstrual cycle or estro-progestin pill in females. We also described an association between some urinary proteins and the renin-angiotensin-aldosterone system, which might help to improve the understanding of physiological and pathological processes when a gender-specific pattern such as the menopause-related hypertension or eclampsia is evident. We therefore support the usefulness of urinary proteomics as a valuable tool for clinically related study as it can provide information on candidate biomarkers which, in turn, need to be confirmed by multiple approaches before the use in a clinical setting.
authors.affiliation: Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Castagna
authors.forename: Sarath Kiran
authors.initials: SK
authors.lastname: Channavajjhala
authors.forename: Francesca
authors.initials: F
authors.lastname: Pizzolo
authors.forename: Oliviero
authors.initials: O
authors.lastname: Olivieri
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000652:urine; D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000652:urine*; D020543:Proteome / Q000032:analysis* / Q000187:drug effects*; D012084:Renin-Angiotensin System; D012697:Serine Endopeptidases / Q000652:urine; D015843:Serpins / Q000652:urine; D000099271:Prostasin
chemical_list: D015415:Biomarkers; D003276:Contraceptives, Oral; D020543:Proteome; D012697:Serine Endopeptidases; D015843:Serpins; D000099271:Prostasin