title: Morphological and functional changes in the thymus and spleen of mouse offspring in the development of systemic inflammatory response after a single immunity stimulation in early pregnancy.
abstract: We studied morphological and functional changes in the thymus and spleen of mouse offspring subjected to single immune stimulation with concanavalin A at early pregnancy terms against the background of systemic inflammatory response. The offspring was characterized less pronounced accidental involution of the thymus, reduced counts of neutrophils in the marginal zone and red pulp of the spleen, mast cell degranulation, and their reduced content in the red pulp.
authors.affiliation: Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia, ober@mail.ru.
authors.forename: S S
authors.initials: SS
authors.lastname: Obernikhin
authors.forename: N V
authors.initials: NV
authors.lastname: Yaglova
mesh_terms: D000818:Animals; D015550:Cell Degranulation / Q000187:drug effects / Q000502:physiology; D003208:Concanavalin A / Q000008:administration & dosage / Q000276:immunology / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000187:drug effects; D007091:Image Processing, Computer-Assisted; D008407:Mast Cells / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009504:Neutrophils / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000276:immunology*; D013154:Spleen / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D018709:Statistics, Nonparametric; D018746:Systemic Inflammatory Response Syndrome / Q000473:pathology*; D013950:Thymus Gland / Q000187:drug effects* / Q000276:immunology / Q000473:pathology
chemical_list: D003208:Concanavalin A