title: Apolipoprotein E genotype and cognitive function in postmenopausal women with early-stage breast cancer.
abstract: OBJECTIVE
  To examine the role of apolipoprotein E (APOE) genotype in the cognitive function of postmenopausal women with early-stage breast cancer prior to initiation of adjuvant therapy and over time with treatment.
  
  
  METHODS
  Longitudinal, genetic association study.
  
  
  METHODS
  Urban university cancer center.
  
  
  METHODS
  Three cohorts of postmenopausal women: 37 women with breast cancer receiving chemotherapy and anastrozole, 41 women with breast cancer receiving anastrozole alone, and 50 healthy women.
  
  
  METHODS
  Cognitive function was evaluated three times during a 12-month period using a comprehensive neuropsychological test battery. Participants were genotyped and classified based on the presence or absence of at least one APOE e4 allele. Multiple linear regression was used to determine if APOE genotype accounted for observed variability in cognitive function data.
  
  
  METHODS
  APOE genotype, breast cancer treatment, and cognitive function.
  
  
  RESULTS
  Performance or changes in performance on tasks of executive function, attention, verbal learning and memory, and visual learning and memory were found to be influenced by APOE genotype and/or interactions between APOE genotype and study cohort.
  
  
  CONCLUSIONS
  The results indicate that cognitive function in postmenopausal women with breast cancer is modified by APOE genotype and the combination of APOE genotype and treatment.
  
  
  CONCLUSIONS
  APOE genotype, along with other biomarkers, may be used in the future to assist nurses in identifying women with breast cancer most at risk for cognitive decline.
authors.affiliation: School of Nursing, University of Pittsburgh in Pennsylvania.
authors.forename: Theresa A
authors.initials: TA
authors.lastname: Koleck
authors.affiliation: School of Nursing, University of Pittsburgh in Pennsylvania.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Bender
authors.affiliation: Department of Biostatistics, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh in Pennsylvania.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Sereika
authors.affiliation: Department of Surgery, Division of Surgical Oncology, in the School of Medicine, University of Pittsburgh in Pennsylvania.
authors.forename: Gretchen
authors.initials: G
authors.lastname: Ahrendt
authors.affiliation: Department of Medicine in the School of Medicine, University of Pittsburgh in Pennsylvania.
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Jankowitz
authors.affiliation: Department of Surgery in the School of Medicine, University of Pittsburgh in Pennsylvania.
authors.forename: Kandace P
authors.initials: KP
authors.lastname: McGuire
authors.affiliation: School of Nursing and in the Department of Psychiatry in the School of Medicine, University of Pittsburgh in Pennsylvania.
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Ryan
authors.affiliation: Department of Human Genetics in the Graduate School of Public Health, University of Pittsburgh in Pennsylvania.
authors.forename: Yvette P
authors.initials: YP
authors.lastname: Conley
mesh_terms: D001057:Apolipoproteins E / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology / Q000523:psychology*; D003071:Cognition; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D009367:Neoplasm Staging; D017698:Postmenopause
chemical_list: D001057:Apolipoproteins E
keywords: biologic markers; breast neoplasms; cognition; genes