title: Induced pluripotent stem cells in dermatology: potentials, advances, and limitations.
abstract: The discovery of methods for reprogramming adult somatic cells into induced pluripotent stem cells (iPSCs) has raised the possibility of producing truly personalized treatment options for numerous diseases. Similar to embryonic stem cells (ESCs), iPSCs can give rise to any cell type in the body and are amenable to genetic correction by homologous recombination. These ESC properties of iPSCs allow for the development of permanent corrective therapies for many currently incurable disorders, including inherited skin diseases, without using embryonic tissues or oocytes. Here, we review recent progress and limitations of iPSC research with a focus on clinical applications of iPSCs and using iPSCs to model human diseases for drug discovery in the field of dermatology.
authors.affiliation: Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
authors.forename: Ganna
authors.initials: G
authors.lastname: Bilousova
authors.affiliation: Department of Dermatology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045 Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, University of Colorado, Anschutz Medical Campus, Aurora, Colorado 80045.
authors.forename: Dennis R
authors.initials: DR
authors.lastname: Roop
mesh_terms: D002454:Cell Differentiation / Q000502:physiology; D065150:Cellular Reprogramming / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D009030:Mosaicism; D012871:Skin Diseases / Q000628:therapy*; D012873:Skin Diseases, Genetic / Q000628:therapy