title: Field testing the ENSEMBLE Minimum Dataset: performance of an instrument to address heterogeneity of treatment effects.
abstract: OBJECTIVE
  To assess the ability of ENterprising SElective Multi-instrument BLend for hEterogeneity analysis (ENSEMBLE) Minimum Dataset instrument dimensions to discriminate among subgroups of patients expected to have differential outcomes.
  
  
  METHODS
  Patients with Type 2 diabetes, knee osteoarthritis, ischemic heart disease or heart failure completed a survey designed to represent three dimensions (health, personality and behavior). Health-related outcomes and utilization were investigated using claims data. Discriminant validity and associations between the dimensions and outcomes were assessed.
  
  
  RESULTS
  A total of 2625 patients completed the survey. The dimensions discriminated 50-100% of the outcome levels across disease cohorts; behavior dimension scores did not differ significantly among the healthcare utilization level subgroups in any disease cohort.
  
  
  CONCLUSIONS
  ENSEMBLE Minimum Dataset dimensions discriminated health-related outcome levels among patients with varied diseases.
authors.affiliation: Health Economics & Outcomes Research, Optum, Eden Prairie, MN 55344, USA.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Brenneman
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.forename: Lee
authors.initials: L
authors.lastname: Brekke
authors.forename: Rosirene
authors.initials: R
authors.lastname: Paczkowski
authors.forename: Tim
authors.initials: T
authors.lastname: Bancroft
authors.forename: Sherrie H
authors.initials: SH
authors.lastname: Kaplan
authors.forename: Sheldon
authors.initials: S
authors.lastname: Greenfield
authors.forename: Marc
authors.initials: M
authors.lastname: Berger
authors.forename: Don P
authors.initials: DP
authors.lastname: Buesching
mesh_terms: D057186:Comparative Effectiveness Research / Q000379:methods / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D066264:Datasets as Topic / Q000592:standards*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D005260:Female; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000628:therapy*; D020370:Osteoarthritis, Knee / Q000628:therapy*; D010043:Outcome and Process Assessment, Health Care / Q000379:methods* / Q000706:statistics & numerical data; D063868:Patient Outcome Assessment; D015203:Reproducibility of Results; D012189:Retrospective Studies; D011795:Surveys and Questionnaires
keywords: healthcare utilization; heterogeneity of treatment effect; patient-reported health status; questionnaires