title: Appreciating force and shape—the rise of mechanotransduction in cell biology.
abstract: Although the shapes of organisms are encoded in their genome, the developmental processes that lead to the final form of vertebrates involve a constant feedback between dynamic mechanical forces, and cell growth and motility. Mechanobiology has emerged as a discipline dedicated to the study of the effects of mechanical forces and geometry on cell growth and motility—for example, during cell-matrix adhesion development—through the signalling process of mechanotransduction.
authors.affiliation: 1] Department of Biological Sciences, Columbia University, New York 10027, USA. [2].
authors.forename: Thomas
authors.initials: T
authors.lastname: Iskratsch
authors.affiliation: 1] Department of Biological Sciences, Columbia University, New York 10027, USA. [2].
authors.forename: Haguy
authors.initials: H
authors.lastname: Wolfenson
authors.affiliation: Mechanobiology Institute, National University of Singapore, Singapore 117411, and the Department of Biological Sciences, Columbia University, New York 10027, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Sheetz
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D003585:Cell Biology / Q000266:history*; D005109:Extracellular Matrix / Q000502:physiology; D049673:History, 20th Century; D049674:History, 21st Century; D040542:Mechanotransduction, Cellular