title: Acetal-linked branched poly(dimethyl-aminoethyl methacrylate) as an acid cleavable gene vector with reduced cytotoxicity.
abstract: An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. The degradation of the polymer was strongly pH-dependent. High nucleic acid transfection efficiency with low cytotoxicity was observed compared to its non-degradable copolymer counterpart.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, and Shanghai Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China. caohl@ecust.edu.cn.
authors.forename: H L
authors.initials: HL
authors.lastname: Cao
authors.forename: Y X
authors.initials: YX
authors.lastname: Dong
authors.forename: A
authors.initials: A
authors.lastname: Aied
authors.forename: T Y
authors.initials: TY
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: W X
authors.initials: WX
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Pandit
mesh_terms: D000080:Acetals / Q000138:chemical synthesis / Q000737:chemistry*; D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D002460:Cell Line; D004247:DNA / Q000008:administration & dosage* / Q000235:genetics; D006868:Hydrolysis; D008156:Luciferases / Q000235:genetics; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry*; D010957:Plasmids / Q000008:administration & dosage* / Q000235:genetics; D011817:Rabbits; D013234:Stem Cells / Q000378:metabolism; D014162:Transfection
chemical_list: D000080:Acetals; D008689:Methacrylates; D009757:Nylons; C407037:poly(2-(dimethylamino)ethyl methacrylate); D004247:DNA; D008156:Luciferases