title: ESC working group cellular biology of the heart: position paper: improving the preclinical assessment of novel cardioprotective therapies.
abstract: Ischaemic heart disease (IHD) remains the leading cause of death and disability worldwide. As a result, novel therapies are still needed to protect the heart from the detrimental effects of acute ischaemia-reperfusion injury, in order to improve clinical outcomes in IHD patients. In this regard, although a large number of novel cardioprotective therapies discovered in the research laboratory have been investigated in the clinical setting, only a few of these have been demonstrated to improve clinical outcomes. One potential reason for this lack of success may have been the failure to thoroughly assess the cardioprotective efficacy of these novel therapies in suitably designed preclinical experimental animal models. Therefore, the aim of this Position Paper by the European Society of Cardiology Working Group Cellular Biology of the Heart is to provide recommendations for improving the preclinical assessment of novel cardioprotective therapies discovered in the research laboratory, with the aim of increasing the likelihood of success in translating these new treatments into improved clinical outcomes.
authors.affiliation: Hatter Institute for Cardiovascular Research in Africa and MRC Inter-University Cape Heart Group, University of Cape Town, Cape Town, South Africa.
authors.forename: Sandrine
authors.initials: S
authors.lastname: Lecour
authors.affiliation: Department of Cardiology, Aarhus University Hospital Skejby, Aarhus N, Denmark.
authors.forename: Hans E
authors.initials: HE
authors.lastname: Bøtker
authors.affiliation: Humanitas Clinical and Research Institute, National Research Council of Italy, Rozzano, Italy.
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Condorelli
authors.affiliation: The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews.
authors.forename: Sean M
authors.initials: SM
authors.lastname: Davidson
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Garcia-Dorado
authors.affiliation: Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.
authors.forename: Felix B
authors.initials: FB
authors.lastname: Engel
authors.affiliation: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Pharmahungary Group, Szeged, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Ferdinandy
authors.affiliation: Institut für Pathophysiologie, West German Heart and Vascular Centre, Universitätsklinikum Essen, Essen, Germany.
authors.forename: Gerd
authors.initials: G
authors.lastname: Heusch
authors.affiliation: Institute of Cardiology and Center of Excellence on Aging, 'G. d'Annunzio' University of Chieti, Chieti, Italy Texas Heart Institute, Houston, TX, USA Department of Internal Medicine, University of Texas Medical School, Center of Cardiovascular and Atherosclerosis Research, Houston, TX, USA.
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Madonna
authors.affiliation: Inserm U 1060 (CarMeN_Cardioprotection Team) & CIC de Lyon, Service d'Exploration Fonctionnelles Cardiovasculaires, Hospices Civils de Lyon, Université Claude Bernard Lyon1, Lyon, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Ovize
authors.affiliation: Department of Cardiology, Vall d'Hebron University Hospital and Research Institute, Universitat Autónoma de Barcelona, Barcelona, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: Ruiz-Meana
authors.affiliation: Justus Liebig University Giessen, Giessen, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Schulz
authors.affiliation: University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Joost P G
authors.initials: JP
authors.lastname: Sluijter
authors.affiliation: University Medical Center Utrecht and Hubrecht Institute, Utrecht, the Netherlands.
authors.forename: Linda W
authors.initials: LW
authors.lastname: Van Laake
authors.affiliation: The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews.
authors.forename: Derek M
authors.initials: DM
authors.lastname: Yellon
authors.affiliation: The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews d.hausenloy@ucl.ac.uk.
authors.forename: Derek J
authors.initials: DJ
authors.lastname: Hausenloy
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D017202:Myocardial Ischemia / Q000628:therapy*; D057170:Translational Research, Biomedical
keywords: Animal models; Cardioprotection; Ischaemia; Myocardial infarction; Reperfusion