title: Metal-free synthesis of oxindoles via (NH4)2S2O8-mediated halocarbocyclization of alkenes in water.
abstract: A metal-free synthesis of oxindoles was achieved through the (NH4)2S2O8-mediated halocarbocyclization of alkenes. This protocol provides a practical and environmentally benign method for the construction of halo-containing oxindoles in water. The advantages of this reaction are its good functional group tolerance and mild reaction conditions. On the basis of experimental observations, a plausible reaction mechanism is proposed.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
authors.forename: Ming-Zhong
authors.initials: MZ
authors.lastname: Zhang
authors.forename: Wen-Bing
authors.initials: WB
authors.lastname: Sheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
authors.forename: Mi
authors.initials: M
authors.lastname: Tian
authors.forename: Yong
authors.initials: Y
authors.lastname: Yin
authors.forename: Can-Cheng
authors.initials: CC
authors.lastname: Guo
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D000078183:Oxindoles; D014867:Water / Q000737:chemistry*
chemical_list: D000475:Alkenes; D006846:Hydrocarbons, Halogenated; D007211:Indoles; D008670:Metals; D000078183:Oxindoles; D014867:Water; C022960:2-oxindole