title: Gastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus.
abstract: Medical therapy for type 2 diabetes mellitus is ineffective in the long term due to the progressive nature of the disease, which requires increasing medication doses and polypharmacy. Conversely, bariatric surgery has emerged as a cost-effective strategy for obese diabetic individuals; it has low complication rates and results in durable weight loss, glycemic control and improvements in the quality of life, obesity-related co-morbidity and overall survival. The finding that glucose homeostasis can be achieved with a weight loss-independent mechanism immediately after bariatric surgery, especially gastric bypass, has led to the paradigm of metabolic surgery. However, the primary focus of metabolic surgery is the alteration of the physio-anatomy of the gastrointestinal tract to achieve glycemic control, metabolic control and cardio-metabolic risk reduction. To date, metabolic surgery is still not well defined, as it is used most frequently for less obese patients with poorly controlled diabetes. The mechanism of glycemic control is still incompletely understood. Published research findings on metabolic surgery are promising, but many aspects still need to be defined. This paper examines the proposed mechanism of diabetes remission, the efficacy of different types of metabolic procedures, the durability of glucose control, and the risks and complications associated with this procedure. We propose a tailored approach for the selection of the ideal metabolic procedure for different groups of patients, considering the indications and prognostic factors for diabetes remission.
authors.affiliation: Eng-Hong Pok, Division of Upper GI Surgery, Department of Surgery, University Malaya Medical Center, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Eng-Hong
authors.initials: EH
authors.lastname: Pok
authors.affiliation: Eng-Hong Pok, Division of Upper GI Surgery, Department of Surgery, University Malaya Medical Center, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Wei-Jei
authors.initials: WJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D050110:Bariatric Surgery / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D009765:Obesity / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D018579:Patient Selection; D012074:Remission Induction; D012307:Risk Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: Efficacy; Gastrointestinal surgery; Glucolipotoxicity; Metabolic surgery; Prognostic factor; Type-2 diabetes mellitus