title: Effect of Ginkgo biloba extract on lipopolysaccharide-induced anhedonic depressive-like behavior in male rats.
abstract: The peripheral administration of lipopolysaccharide (LPS) induces depressive-like behavior. Anhedonia is a core symptom of depression, defined as a loss of the capacity to experience pleasure. The present study used the sucrose preference test to investigate the influence of Ginkgo biloba extract (EGb 761) on LPS-induced anhedonia in male rats. The animals were randomly divided into four groups: (I) vehicle + saline, (II) vehicle + LPS, (III) EGb 761 + saline, and (IV) EGb 761 + LPS. Saline or LPS (100 µg/kg) was administered intraperitoneally 2 h before the sucrose preference test. Sucrose consumption was recorded 2, 4, 6, 13, and 24 h after 100 µg/kg of LPS or saline injection in the dark phase of the light/dark cycle. Dopamine and serotonin levels in the nucleus accumbens were measured. Our results indicated that the vehicle + LPS group exhibited a significant decrease in sucrose intake compared with the vehicle + saline group. The EGb 761 + LPS group showed more sucrose and food consumption than the vehicle + LPS group. Additionally, compared with the EGb 761 + LPS group, the vehicle + LPS group had less dopamine levels in the nucleus accumbens. Treatment with EGb 761 had no effect on water intake. Our results suggest that EGb 761 may be useful for reducing anhedonic depressive-like behavior.
authors.affiliation: Department of Physical Therapy, HungKuang University, Taichung, Taiwan.
authors.forename: Kuei-Ying
authors.initials: KY
authors.lastname: Yeh
authors.forename: Sing-Siang
authors.initials: SS
authors.lastname: Shou
authors.forename: Yi-Xuan
authors.initials: YX
authors.lastname: Lin
authors.forename: Chao-Cin
authors.initials: CC
authors.lastname: Chen
authors.forename: Chen-Yen
authors.initials: CY
authors.lastname: Chiang
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Yeh
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003863:Depression / Q000188:drug therapy*; D004298:Dopamine / Q000737:chemistry; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D020441:Ginkgo biloba / Q000737:chemistry; D008070:Lipopolysaccharides; D008297:Male; D009714:Nucleus Accumbens / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000737:chemistry; D000096983:Ginkgo Extract
chemical_list: D004298:Dopamine; D008070:Lipopolysaccharides; D010936:Plant Extracts; D012701:Serotonin; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract
keywords: EGb 761; anhedonia; lipopolysaccharide; rat; sucrose preference test