title: Comparison of pharmacokinetics and relative bioavailability of tablets and substance of new dipeptide neuroleptic dilept.
abstract: We studied pharmacokinetics of dilept after single cross-administration of tablets and substance of dilept in a dose of 40 mg to rabbits. The following pharmacokinetic parameters were calculated: maximum plasma concentration of dilept, time to maximum observed concentration, area under the pharmacokinetic curve, elimination half-life, and relative bioavailability. Dilept concentration in blood plasma was estimated using ultra-fast liquid chromatography with mass spectrometry detection. Relative bioavailability of dilept tablets was 93.46±28.91% of that for the substance.
authors.affiliation: Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, rmn.shev@gmail.com.
authors.forename: R V
authors.initials: RV
authors.lastname: Shevchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: V V
authors.initials: VV
authors.lastname: Smirnov
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D015233:Models, Statistical; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D011817:Rabbits; D013607:Tablets; D013997:Time Factors; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics
chemical_list: C401484:GZR 123; D013607:Tablets; D014443:Tyrosine; D011392:Proline