title: Effects of Arctium lappa L. (Burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis.
abstract: OBJECTIVE
  This study was designed to examine the effect of Burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (OA).
  
  
  METHODS
  Thirty-six patients (10 men and 26 women) aged 50-70 years old with knee osteoarthritis referred to the Physical Medicine and Rehabilitation Department of the Tabriz University of Medical Sciences Hospitals, were selected for the study and randomly divided into two groups. Anthropometric measurements, including height, weight and body mass index (BMI) were measured. For all individuals along the 42 days of study period, the same drug treatments, including two lots of 500 mg acetaminophen twice a day and one glucosamine 500 mg once a day,were considered. The intervention group received daily three cups of Burdock root tea (each cup containing 2 g/150 mL boiled water) half-hour after the meal. The control group received three cups containing 150 cc boiled water daily. We assessed inflammatory markers such as high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) and oxidative stress indicators such as total antioxidants capacity (TAC), glutathione peroxidase (GPX), superoxide dismutase (SOD) and thiobarbituric acid reactive substances before and after the intervention.
  
  
  RESULTS
  The results showed that burdock root tea significantly decreased the levels of serum IL-6 (P = 0.002), hs-CRP (P = 0.003) and malondialdehyde (P < 0.001), while the levels of serum TAC (P < 0.001) and activities of SOD (P = 0.009) were significantly increased. GPX activities increased but not significantly.
  
  
  CONCLUSIONS
  The results suggested that Arctium lappa L. root tea improves inflammatory status and oxidative stress in patients with knee osteoarthritis.
authors.affiliation: Students' Research Committee, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Maghsoumi-Norouzabad
authors.affiliation: Department of Community Nutrition, Faculty of Nutrition, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Beitollah
authors.initials: B
authors.lastname: Alipoor
authors.affiliation: Students' Research Committee, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Abed
authors.affiliation: Physical Medicine and Rehabilitation, Faculty of Medicine, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Bina
authors.initials: B
authors.lastname: Eftekhar Sadat
authors.affiliation: Drug Applied Research Center, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Mesgari-Abbasi
authors.affiliation: Road Traffic Injury Research Center, Tabriz University (Medical Sciences), Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Asghari Jafarabadi
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D031170:Arctium / Q000737:chemistry; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D007492:Iran; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D018517:Plant Roots; D010946:Plants, Medicinal; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D015415:Biomarkers; D018836:Inflammation Mediators; D010936:Plant Extracts
keywords: Arctium Lappa L.; IL-6; hs-CRP; osteoarthritis; oxidative stress