title: Autophagy and regulation of cilia function and assembly.
abstract: Motile and primary cilia (PC) are microtubule-based structures located at the cell surface of many cell types. Cilia govern cellular functions ranging from motility to integration of mechanical and chemical signaling from the environment. Recent studies highlight the interplay between cilia and autophagy, a conserved cellular process responsible for intracellular degradation. Signaling from the PC recruits the autophagic machinery to trigger autophagosome formation. Conversely, autophagy regulates ciliogenesis by controlling the levels of ciliary proteins. The cross talk between autophagy and ciliated structures is a novel aspect of cell biology with major implications in development, physiology and human pathologies related to defects in cilium function.
authors.affiliation: 1] INSERM U1151-CNRS UMR 8253, Paris, France [2] Institut Necker Enfants-Malades (INEM), Paris, France [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Orhon
authors.affiliation: 1] INSERM U1151-CNRS UMR 8253, Paris, France [2] Institut Necker Enfants-Malades (INEM), Paris, France [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Dupont
authors.affiliation: 1] Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA [2] Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: O
authors.initials: O
authors.lastname: Pampliega
authors.affiliation: 1] Department of Development and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY, USA [2] Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Cuervo
authors.affiliation: 1] INSERM U1151-CNRS UMR 8253, Paris, France [2] Institut Necker Enfants-Malades (INEM), Paris, France [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Codogno
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D002923:Cilia / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction