title: DNA synthesis in periportal and perivenous hepatocytes of intact and hepatectomized young mice.
abstract: DNA synthesis of hepatocytes in two areas of Intact and Hepatectomized young mice liver along a circadian period was studied. DNA synthesis was significantly different at all analyzed time points in Intact and Hepatectomized animals. Differences between periportal and perivenous hepatocytes were found in hepatectomized animals at 04/42 and 08/46 hr of day/hour post-hepatectomy. DNAs peak in periportal hepatocytes regenerating liver occurs 4 hr earlier than in perivenous hepatocytes, probably reflecting their shorter G1 phase. Besides, daily mean values of regenerating livers were higher than those observed in Intact animals, as a consequence of surgical removal.
authors.affiliation: a Cátedra de Citología, Histología y Embriología "A", Facultad de Ciencias Médicas , Universidad Nacional de La Plata , La Plata , Buenos Aires , Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Fernández-Blanco
authors.forename: A M
authors.initials: AM
authors.lastname: Inda
authors.forename: A L
authors.initials: AL
authors.lastname: Errecalde
mesh_terms: D000818:Animals; D004261:DNA Replication; D006498:Hepatectomy; D022781:Hepatocytes / Q000378:metabolism*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H
keywords: bromodeoxyuridine; circadian variations; liver regeneration; lobule; mouse; zonation