title: Relationship between SERPING1 rs2511989 polymorphism and age-related macular degeneration risk: a meta-analysis.
abstract: OBJECTIVE
  We conducted a meta-analysis aiming to evaluate the relationship between a common polymorphism (rs2511989 G>A) in the SERPING1 gene and the risk of age-related macular degeneration (AMD).
  
  
  METHODS
  The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1, 2013, without any language restrictions. A meta-analysis was conducted using STATA 12.0 software. We calculated a crude odds ratio (OR) with a 95% confidence interval (95% CI) to evaluate the relationships under five genetic models.
  
  
  RESULTS
  Seven case-control studies with a total of 7,159 patients with AMD and 5,797 healthy subjects met the inclusion criteria. The results of our meta-analysis showed that the SERPING1 rs2511989 polymorphism might be correlated with an increased risk of AMD (G allele versus A allele: OR = 1.09, 95% CI = 1.03-1.15, p = 0.020; GG + GA versus AA: OR = 1.14, 95% CI = 1.03-1.26, p = 0.014; GG versus GA+AA: OR = 1.10, 95% CI = 1.02-1.19, p = 0.012; GG versus AA: OR = 1.20, 95% CI = 1.07-1.34, p = 0.002; respectively). Results of subgroup analysis by ethnicity revealed positive correlations between the SERPING1 rs2511989 polymorphism and risk of AMD among Caucasians under five genetic models (all p<0.05), but not among Asians (all p>0.05).
  
  
  CONCLUSIONS
  The current meta-analysis shows that the SERPING1 rs2511989 polymorphism may have a positive effect on the risk of AMD, especially among Caucasians.
authors.affiliation: Department of Ophthalmology, Heilongjiang Provincial Hospital, Harbin, P.R. China.
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Ma
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
authors.forename: Shao-Ying
authors.initials: SY
authors.lastname: Fu
authors.affiliation: Liaoning Electric Power Spa Sanatorium of Xingcheng City, P.R. China.
authors.forename: Yan-Hua
authors.initials: YH
authors.lastname: Ma
authors.affiliation: Department of Ophthalmology, the First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Liu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D003174:Complement C1 Inactivator Proteins / Q000235:genetics*; D050718:Complement C1 Inhibitor Protein; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People
chemical_list: D003174:Complement C1 Inactivator Proteins; D050718:Complement C1 Inhibitor Protein; C469952:SERPING1 protein, human