title: Drug-induced subacute cutaneous lupus erythematosus associated with docetaxel chemotherapy: a case report.
abstract: BACKGROUND
  Drug-induced subacute cutaneous lupus erythematosus is an uncommon disorder associated with the use of pharmacological agents including systemic chemotherapy.
  
  
  METHODS
  We report a case of docetaxel-induced subacute cutaneous lupus erythematosus in a 60-year-old Caucasian female with Sjögren's syndrome diagnosed 2 months after receiving docetaxel as part of the adjuvant FEC-D (5-fluorouracil, epirubicin, cyclophosphamide, docetaxel) chemotherapy protocol for early stage breast cancer. Although the exact mechanisms behind the autoimmune response elicited by docetaxel are unclear, the involvement of anti-SSA/Ro antibodies has been implicated.
  
  
  CONCLUSIONS
  This case highlights the symptom severity and clinical course of docetaxel-induced subacute cutaneous lupus erythematosus, and highlights the importance of recognizing this uncommon but potentially severe chemotherapy-associated cutaneous reaction.
authors.forename: Noelle Y
authors.initials: NY
authors.lastname: Wong
authors.forename: Laurie M
authors.initials: LM
authors.lastname: Parsons
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Trotter
authors.affiliation: Department of Oncology, Division of Medical Oncology, University of Calgary, Tom Baker Cancer Centre, 1331 29 St NW, Calgary, Alberta T2N 4N2, Canada. roger.tsang@albertahealthservices.ca.
authors.forename: Roger Y
authors.initials: RY
authors.lastname: Tsang
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001706:Biopsy; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D000077143:Docetaxel; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D005260:Female; D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008875:Middle Aged; D009367:Neoplasm Staging; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000276:immunology; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000974:Antibodies, Antinuclear; C035356:SS-A antibodies; D043823:Taxoids; D000077143:Docetaxel