title: Neodymium yttrium-aluminium-garnet laser resection significantly improves quality of life in patients with malignant central airway obstruction due to lung cancer.
abstract: Neodymium yttrium-aluminium-garnet (Nd : YAG) laser resection is one of the mostly used interventional pulmonology techniques for urgent desobstruction of malignant central airway obstruction (CAO). The major aim of this trial was to evaluate potential influence of Nd : YAG laser resection on overall quality of life (QoL) in patients with central lung cancer. Patients with malignant CAO scheduled for Nd : YAG laser resection were prospectively recruited in the trial. All patients were given European Organization for Research and Treatment, Quality of Life questionnaire (EORTC QLQ-30 v.3) before the procedure and approximately 2 weeks after the treatment. There were 37 male and 10 female patients, average age 54 ± 10 years. Most common tumour type was adenocarcinoma diagnosed in 51% of patients. Majority of patients were diagnosed in stage IIIB (53.2%) and stage IV (25.5%). Most common Eastern Cooperative Oncology Group performance status was 1 (72.3%). Nd : YAG laser resection significantly improved (P<0.0001) QoL and overall health according to EORTC QLQ-30. However, in some of the questions dealing with nausea, vomiting, diarrhoea, constipation, family life, social activities and financial situation, we did not observe statistically significant improvement. Nd : YAG laser resection of malignant CAO significantly improves QoL and overall health in patients with lung cancer.
authors.affiliation: Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: B
authors.initials: B
authors.lastname: Zaric
authors.affiliation: Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: T
authors.initials: T
authors.lastname: Kovacevic
authors.affiliation: Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: V
authors.initials: V
authors.lastname: Stojsic
authors.affiliation: Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: T
authors.initials: T
authors.lastname: Sarcev
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Kocic
authors.affiliation: Scientific Institute of Reproduction and Artificial Insemination of Domestic Animals 'Temerin', University of Novi Sad, Novi Sad, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Urosevic
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: D
authors.initials: D
authors.lastname: Kalem
authors.affiliation: Clinic for Thoracic Oncology, Institute for Pulmonary Diseases of Vojvodina, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
authors.forename: B
authors.initials: B
authors.lastname: Perin
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery*; D000402:Airway Obstruction / Q000209:etiology / Q000601:surgery*; D000535:Aluminum / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000601:surgery*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009354:Neodymium / Q000627:therapeutic use; D011446:Prospective Studies; D011788:Quality of Life; D016896:Treatment Outcome; D015019:Yttrium / Q000627:therapeutic use
chemical_list: C503779:yttrium-aluminum-garnet; D009354:Neodymium; D015019:Yttrium; D000535:Aluminum
keywords: EORTC QLQ-C30; Nd : YAG laser resection; interventional pulmonology; lung cancer; quality of life