title: 18F-labelled intermediates for radiosynthesis by modular build-up reactions: newer developments.
abstract: This brief review gives an overview of newer developments in (18)F-chemistry with the focus on small (18)F-labelled molecules as intermediates for modular build-up syntheses. The short half-life (<2 h) of the radionuclide requires efficient syntheses of these intermediates considering that multistep syntheses are often time consuming and characterized by a loss of yield in each reaction step. Recent examples of improved synthesis of (18)F-labelled intermediates show new possibilities for no-carrier-added ring-fluorinated arenes, novel intermediates for tri[(18)F]fluoromethylation reactions, and (18)F-fluorovinylation methods.
authors.affiliation: Institut für Neurowissenschaften und Medizin, INM-5: Nuklearchemie, Forschungszentrum Jülich, 52425 Jülich, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Ermert
mesh_terms: D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals