title: New prenylated carbazole alkaloids from Zanthoxylum armatum.
abstract: A phytochemical investigation on the ethyl acetate soluble fraction of Zanthoxylum armatum led in the isolation of two new prenylated alkaloids 2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carbaldehyde (1) and methyl-2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carboxylate (2), along with three known lignans cisamin (3), methyl pirpirtol (4), and fargesin (5) and one known alkaloid dictamine (6). Their structures were established on the basis of spectroscopic and crystallographic analysis and by comparison of the data with those in the literature. All the isolated compounds were screened for the DPPH free radical scavenging activity. Compounds 1, 2, and 6 showed profound activity while compounds 3-5 showed moderate activity.
authors.affiliation: a Department of Chemistry , Gomal University , Dera Ismail Khan 29050 , KPK , Pakistan.
authors.forename: Abdul
authors.initials: A
authors.lastname: Samad
authors.forename: Syed
authors.initials: S
authors.lastname: Badshah
authors.forename: Dilfaraz
authors.initials: D
authors.lastname: Khan
authors.forename: Farman
authors.initials: F
authors.lastname: Ali
authors.forename: Malik
authors.initials: M
authors.lastname: Amanullah
authors.forename: Jane
authors.initials: J
authors.lastname: Hanrahan
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D052117:Benzodioxoles / Q000302:isolation & purification; D001713:Biphenyl Compounds / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification; D015394:Molecular Structure; D010154:Pakistan; D010851:Picrates / Q000494:pharmacology; D054876:Prenylation; D011804:Quinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: C000595820:2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carbaldehyde; D000470:Alkaloids; D052117:Benzodioxoles; D001713:Biphenyl Compounds; D002227:Carbazoles; D016166:Free Radical Scavengers; D017705:Lignans; D010851:Picrates; D011804:Quinolines; C000595821:methyl-2,6,7-trimethoxy-8-(3-methyl-2-butenyl)carbazole-3-carboxylate; C004931:1,1-diphenyl-2-picrylhydrazyl; C539377:fargesin; C026398:dictamnine
keywords: DPPH radical scavenging activity; Rutaceae; Zanthoxylum armatum; alkaloids