title: Effect of nano-scale curvature on the intrinsic blood coagulation system.
abstract: The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kushida
authors.forename: Krishnendu
authors.initials: K
authors.lastname: Saha
authors.forename: Chandramouleeswaran
authors.initials: C
authors.lastname: Subramani
authors.forename: Vikas
authors.initials: V
authors.lastname: Nandwana
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D001777:Blood Coagulation; D005174:Factor XII / Q000737:chemistry*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D011489:Protein Denaturation; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D012822:Silicon Dioxide; D005174:Factor XII