title: Sulfonamide-bridged nucleic acid: synthesis, high RNA selective hybridization, and high nuclease resistance.
abstract: 2'-N,4'-C-(N-methylamino)sulfonylmethylene-bridged thymidine (SuNA), which has a six-membered linkage including a sulfonamide moiety, was synthesized and introduced into oligonucleotides. The oligonucleotides containing SuNA exhibited excellent nuclease resistance, a high affinity toward single-stranded RNA, and a low affinity toward single-stranded DNA compared to the natural oligonucleotide.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University , 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Mitsuoka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Fujimura
authors.forename: Reiko
authors.initials: R
authors.lastname: Waki
authors.forename: Akira
authors.initials: A
authors.lastname: Kugimiya
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D009696:Nucleic Acids / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D012260:Ribonucleases / Q000138:chemical synthesis* / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001952:Bridged-Ring Compounds; D009696:Nucleic Acids; D009841:Oligonucleotides; D013449:Sulfonamides; D012313:RNA; D012260:Ribonucleases; D013936:Thymidine