title: Relationship between metformin and frailty syndrome in elderly people with type 2 diabetes.
abstract: OBJECTIVE
  to explore the possibility of metformin protective effect on frailty syndrome.
  
  
  METHODS
  this was a case control study conducted in subjects' ≥60 years old who visited the Geriatrics and Diabetes outpatient clinic of Cipto Mangunkusumo National Referral Hospital between March and June 2013. Diagnosis of frailty was established using the FI-40 item criteria. Statistical analysis was done with chi-square method for bivariate and logistic regression method in multivariate analysis, all data was accompanied with 95% confidence interval.
  
  
  RESULTS
  frailty syndrome was found in 25% of subjects (n = 59), with median age of 72 years old (SD 6.27) and median of FI-40 item score was 0.18 (SD 0.085). Metformin was found to have a significant relationship with frailty syndrome in the elderly diabetics, which retained significant value after multivariate analysis (adjusted OR 0.043; 95% CI 0.019-0.099; p < 0.001).
  
  
  CONCLUSIONS
  metformin was shown to have protective effect against frailty syndrome in elderly diabetics.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Stevent
authors.initials: S
authors.lastname: Sumantri
authors.forename: Siti
authors.initials: S
authors.lastname: Setiati
authors.forename: Dyah
authors.initials: D
authors.lastname: Purnamasari
authors.forename: Esthika
authors.initials: E
authors.lastname: Dewiasty
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy*; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D015999:Multivariate Analysis; D013577:Syndrome
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin