title: Risk of incident coronary artery disease in patients with primary biliary cirrhosis.
abstract: BACKGROUND
  Patients with primary biliary cirrhosis (PBC) often present hyperlipidemia, which is a risk factor of incident coronary artery disease (CAD). However, few studies have examined CAD in PBC.
  
  
  METHODS
  We identified 41 patients who developed CAD amongst 2,675 PBC cases across seven years and selected the PBC patients without CAD as controls according to sex and age.
  
  
  RESULTS
  Females dominated in these patients with CAD. The median time from the diagnosis of PBC to the onset of CAD was 44 months. The patient group with CAD had higher median levels of low-density lipoprotein cholesterol (4.68 mmol/L versus 3.52 mmol/L, P=0.036) and higher proportion of cases with hypertension (63.4% versus 19.5%, P<0.001) compared to that without CAD. In the logistic regression, only hypertension (with versus without, P<0.001; OR, 1.597; 95% CI, 1.139-2.053) was selected.
  
  
  CONCLUSIONS
  PBC patients with hypertension should be monitored carefully due to the risk of incident CAD.
authors.affiliation: Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University Beijing 100029, China.
authors.forename: Chunya
authors.initials: C
authors.lastname: Wang
authors.affiliation: Clinical Trial Center, Liver Failure Therapy and Research Center, Beijing 302 Hospital (PLA 302 Hospital) Beijing 100039, China.
authors.forename: Pan
authors.initials: P
authors.lastname: Zhao
authors.affiliation: Department of Statistics, Academy of Military Medical Science Beijing 100850, China.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Liu
keywords: Coronary artery disease; primary biliary cirrhosis; risk factor