title: An iminocoumarin sulfonamide based turn-on fluorescent probe for the detection of biothiols in aqueous solution.
abstract: A new chemodosimeter for the highly selective sensing and imaging of biothiols was designed and realized in phosphate-buffered saline solution at pH 7.4 through a fluorescence "off-on" response. A unique mechanism featuring a two-step cascade (biothiols→H2 O) sequence for this remarkable recognition is disclosed for the first time.
authors.affiliation: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 (P. R. China), Fax: (+86) 931-8912582.
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Yang
authors.forename: Fu-Ming
authors.initials: FM
authors.lastname: Zhang
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Wang
authors.forename: Bao-Xin
authors.initials: BX
authors.lastname: Zhang
authors.forename: Ran
authors.initials: R
authors.lastname: Fang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Fang
authors.forename: Yu
authors.initials: Y
authors.lastname: Peng
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008856:Microscopy, Fluorescence; D008968:Molecular Conformation; D011789:Quantum Theory; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; D013449:Sulfonamides; C030123:coumarin; D005978:Glutathione; D003545:Cysteine
keywords: biothiols; chemodosimeter; domino reactions; fluorescence; molecular recognition