title: Bone marrow-derived CD13+cells sustain tumor progression: A potential non-malignant target for anticancer therapy.
abstract: Non-malignant cells found within neoplastic lesions express alanyl (membrane) aminopeptidase (ANPEP, best known as CD13), and CD13-null mice exhibit limited tumor growth and angiogenesis. We have recently demonstrated that a subset of bone marrow-derived CD11b+CD13+myeloid cells accumulate within neoplastic lesions in several murine models of transplantable cancer to promote angiogenesis. If these findings were confirmed in clinical settings, CD11b+CD13+myeloid cells could become a non-malignant target for the development of novel anticancer regimens.
authors.affiliation: David H. Koch Center; The University of Texas M.D. Anderson Cancer Center; Houston, TX USA.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Dondossola
authors.affiliation: Division of Molecular Oncology; San Raffaele Scientific Institute; Milan, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Corti
authors.affiliation: Harvard Medical School; Boston, MA USA ; Department of Neurology; Beth Israel-Deaconess Medical Center; Boston, MA USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Sidman
authors.affiliation: University of New Mexico Cancer Center; Albuquerque, NM USA ; Division of Hematology/Oncology and Division of Molecular Medicine; Department of Internal Medicine; University of New Mexico School of Medicine; Albuquerque, NM USA.
authors.forename: Wadih
authors.initials: W
authors.lastname: Arap
authors.affiliation: University of New Mexico Cancer Center; Albuquerque, NM USA ; Division of Hematology/Oncology and Division of Molecular Medicine; Department of Internal Medicine; University of New Mexico School of Medicine; Albuquerque, NM USA.
authors.forename: Renata
authors.initials: R
authors.lastname: Pasqualini
keywords: CD13; angiogenesis; bone marrow-derived cells; mouse models; tumor