title: Volumetric measurement of human red blood cells by MOSFET-based microfluidic gate.
abstract: In this paper, we present a MOSFET-based (metal oxide semiconductor field-effect transistor) microfluidic gate to characterize the translocation of red blood cells (RBCs) through a gate. In the microfluidic system, the bias voltage modulated by the particles or biological cells is connected to the gate of MOSFET. The particles or cells can be detected by monitoring the MOSFET drain current instead of DC/AC-gating method across the electronic gate. Polystyrene particles with various standard sizes are utilized to calibrate the proposed device. Furthermore, RBCs from both adults and newborn blood sample are used to characterize the performance of the device in distinguishing the two types of RBCs. As compared to conventional DC/AC current modulation method, the proposed device demonstrates a higher sensitivity and is capable of being a promising platform for bioassay analysis.
authors.affiliation: Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, P. R. China.|Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore.
authors.forename: Jinhong
authors.initials: J
authors.lastname: Guo
authors.affiliation: Pillar of Engineering Product Development, Singapore University of Technology and Design, Singapore, Singapore.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ai
authors.affiliation: Research Institute of Smart Terminal, Sichuan Changhong Electric Co., Ltd, Mianyang, P. R. China.
authors.forename: Yuanbing
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Institute for Clean Energy & Advanced Materials, Southwest University, Beibei, P. R. China.
authors.forename: Chang Ming
authors.initials: CM
authors.lastname: Li
authors.affiliation: School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
authors.forename: Yuejun
authors.initials: Y
authors.lastname: Kang
authors.affiliation: Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, P. R. China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000328:Adult; D048429:Cell Size; D004867:Equipment Design; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000166:cytology*; D006801:Humans; D007231:Infant, Newborn; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D012666:Semiconductors
keywords: Metal oxide semiconductor field-effect transistor; Microfluidic gate; Red blood cell; Volumetric measurement