title: The ethnic distribution of sickle cell disease in Sudan.
abstract: Sickle cell disease (SCD) is one of the most common inherited disorders of haemoglobin in Africa and it is expected that sickle cell trait varies in frequency in different areas in Sudan. An extensive literature search was carried out accessing the US National Library of Medicine, the WHO Eastern Mediterranean Region resources, the Catalogue for Transmission Genetics in Arabs and papers and documents published in Sudan that included data on the prevalence of sickle cell anaemia and trait. Rates of SCA and trait varied in different areas in Sudan with the highest rates reported from Western and Eastern Sudan where one in every 123 children born in Messeryia tribe in Western Sudan is at risk of having SCD. High consanguinity rates and malaria endemicity are strong related factors with sickle cell gene in Sudan. This review will present what is known about the rates of sickle cell gene in different ethnic groups in Sudan.
authors.affiliation: Reproductive and Child Health Research Unit, University of Medical Sciences and Technology, Khartoum, Sudan.
authors.forename: Majdi Mohammed
authors.initials: MM
authors.lastname: Sabahelzain
authors.affiliation: Department of Genetic Medicine and Development Geneva University, Geneva, Switzerland.
authors.forename: Hanan
authors.initials: H
authors.lastname: Hamamy
mesh_terms: D000755:Anemia, Sickle Cell / Q000453:epidemiology* / Q000208:ethnology; D003241:Consanguinity; D006801:Humans; D008288:Malaria / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D012805:Sickle Cell Trait / Q000453:epidemiology*; D013397:Sudan / Q000453:epidemiology
keywords: Darfur; Haemoglobinopathy; Khartoum; Kordofan; Messeryia; Sickle cell anemia; Sudan; haplotype; sickle cell gene; tribe