title: Influence of sulfur fumigation on the chemical constituents and antioxidant activity of buds of Lonicera japonica.
abstract: Lonicera japonica flos is widely used as a pharmaceutical resource and a commonly-employed ingredient in healthy food, soft beverages and cosmetics in China. Sometimes, sulfur fumigation is used during post-harvest handling. In this study, a comprehensive comparison of the chemical profile between sun-dried and sulfur-fumigated samples was conducted by HPLC fingerprints and simultaneous quantification of nine constituents, including secologanic acid, along with another eight usually-analyzed markers. Secologanic acid was destroyed, and its sulfonates were generated, whereas caffeoylquinic acids were protected from being oxidized. The residual sulfur dioxide in sulfur-fumigated samples was significantly higher than that in sun-dried samples, which might increase the potential incidence of toxicity to humans. Meanwhile, compared with sun-dried samples, sulfur-fumigated samples have significantly stronger antioxidant activity, which could be attributed to the joint effect of protected phenolic acids and flavonoids, as well as newly-generated iridoid sulfonates.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. guoaililu@126.com.
authors.forename: Ai-Li
authors.initials: AL
authors.lastname: Guo
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. chris-clm@163.com.
authors.forename: Liang-Mian
authors.initials: LM
authors.lastname: Chen
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. wangyanmin@126.com.
authors.forename: Yan-Min
authors.initials: YM
authors.lastname: Wang
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. lianyu1127@126.com.
authors.forename: Xiao-Qian
authors.initials: XQ
authors.lastname: Liu
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhangqw1955@163.com.
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Zhang
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. huimin_gao@126.com.
authors.forename: Hui-Min
authors.initials: HM
authors.lastname: Gao
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. zhmw123@263.net.
authors.forename: Zhi-Min
authors.initials: ZM
authors.lastname: Wang
authors.affiliation: Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China. wzhzh-nj@tom.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Jiangsu Kanion Pharmaceutical Co. Ltd., Lianyungang 222001, China. wzhzh-nj@tom.com.
authors.forename: Zhen-Zhong
authors.initials: ZZ
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002681:China; D002851:Chromatography, High Pressure Liquid; D005419:Flavonoids / Q000494:pharmacology; D005651:Fumigation / Q000379:methods; D057889:Iridoid Glycosides / Q000494:pharmacology; D031239:Lonicera / Q000737:chemistry* / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013455:Sulfur / Q000494:pharmacology*; D013458:Sulfur Dioxide / Q000737:chemistry
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D057889:Iridoid Glycosides; D010936:Plant Extracts; C472707:caffeoylquinic acid; D011801:Quinic Acid; D013458:Sulfur Dioxide; D013455:Sulfur