title: Convenient synthesis of N1-substituted orotic acid derivatives.
abstract: A convenient and efficient method for the synthesis of N1-substituted orotic acid derivatives is reported. The synthetic route utilizes substituted maleimide as synthetic intermediate and takes only four simple steps from readily available starting materials. As a result, orotic acid derivatives with various alkyl and aromatic groups at N1 can be readily synthesized.
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
authors.forename: Jeannette T
authors.initials: JT
authors.lastname: Bowler
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
authors.forename: Caitlin R
authors.initials: CR
authors.lastname: Clausen
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Blackburn
authors.affiliation: Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 USA.
authors.forename: Weiming
authors.initials: W
authors.lastname: Wu
keywords: Orotic acid; bromomaleimide; dibromosuccinimide; maleimide; orotidine; synthesis