title: Prenatal detection of congenital heart disease in a low risk population undergoing first and second trimester screening.
abstract: OBJECTIVE
  The prenatal detection rate of congenital heart disease (CHD) is low compared with other fetal malformations. Our aim was to evaluate the prenatal detection of CHD in Eastern Denmark.
  
  
  METHODS
  Fetuses and infants diagnosed with CHD in the period 01.01.2008-31.12.2010 were assessed regarding prenatal detection rate and accuracy, as well as correlation with nuchal translucency (NT) thickness.
  
  
  RESULTS
  Out of 86 121 infants, 831 were born with CHD (0.96%). The prenatal detection rate of 'all CHD' was 21.3%, of 'Major CHD' 47.4%. Full agreement between prenatal and postnatal/autopsy findings was found in 96% of prenatally detected diagnoses. An NT thickness >95(th) percentile was found in 15.0% fetuses with 'Major CHD'. Of 'Major CHDs' detected prenatally, 77% were picked up at the time of the malformation scan at weeks 18-21.
  
  
  CONCLUSIONS
  Nearly half of 'Major CHDs' were detected prenatally. The prenatal cardiac diagnoses showed a high degree of accuracy. Increased NT thickness as a screening tool for CHD performed moderately but is an important high risk group for specialist examination. A minority of the prenatally detected CHDs was identified because of extra scans performed in high risk pregnancies. © 2014 John Wiley & Sons, Ltd.
authors.affiliation: Center of Fetal Medicine and Pregnancy, Copenhagen University Hospital Rigshospitalet, Denmark.
authors.forename: Ditte E S
authors.initials: DE
authors.lastname: Jørgensen
authors.forename: Niels
authors.initials: N
authors.lastname: Vejlstrup
authors.forename: Connie
authors.initials: C
authors.lastname: Jørgensen
authors.forename: Lisa Leth
authors.initials: LL
authors.lastname: Maroun
authors.forename: Jesper
authors.initials: J
authors.lastname: Steensberg
authors.forename: Anette
authors.initials: A
authors.lastname: Hessellund
authors.forename: Finn Stener
authors.initials: FS
authors.lastname: Jørgensen
authors.forename: Torben
authors.initials: T
authors.lastname: Larsen
authors.forename: Anne-Cathrine
authors.initials: AC
authors.lastname: Shalmi
authors.forename: Lillian
authors.initials: L
authors.lastname: Skibsted
authors.forename: Helle
authors.initials: H
authors.lastname: Zingenberg
authors.forename: Charlotte
authors.initials: C
authors.lastname: Ekelund
authors.forename: Ann
authors.initials: A
authors.lastname: Tabor
mesh_terms: D001344:Autopsy; D003718:Denmark; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging; D005333:Fetus; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging*; D006801:Humans; D007231:Infant, Newborn; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D011446:Prospective Studies; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal / Q000379:methods*