title: Stem cell transplantation improves aging-related diseases.
abstract: Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. The number of patients with age-associated diseases such as type 2 diabetes mellitus (T2DM), osteoporosis, Alzheimer's disease (AD), Parkinson's disease, atherosclerosis, and cancer has increased recently. Aging-related diseases are related to a deficiency of the immune system, which results from an aged thymus and bone marrow cells. Intra bone marrow-bone marrow transplantation (IBM-BMT) is a useful method to treat intractable diseases. This review summarizes findings that IBM-BMT can improve and treat aging-related diseases, including T2DM, osteoporosis and AD, in animal models.
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University Hirakata, Osaka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikehara
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University Hirakata, Osaka, Japan.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
keywords: Alzheimer's disease; aging-related diseases; bone marrow transplantation; osteoporosis; type 2 diabetes mellitus