title: Clinical significance of reduced SFRP1 expression in acute myeloid leukemia.
abstract: Deregulation of secreted frizzled-related protein 1 (SFRP1) has been found in many types of cancer. However, the pattern of SFRP1 expression in acute myeloid leukemia (AML) is still unclear. This study determined SFRP1 expression in patients with AML. SFRP1 expression was decreased markedly in patients with AML compared to controls (p < 0.001). White blood cell (WBC) counts increased as SFRP1 expression decreased in AML (p = 0.016). Patients with low SFRP1 expression showed a different distribution of French-American-British (FAB) subtypes M1/M2/M3 from those with high SFRP1 expression (p = 0.031). NPM1 mutation was mainly observed in patients with low SFRP1 expression (p = 0.011). There was a weak trend that patients with AML with low SFRP1 expression had shorter overall survival (OS) than those with high SFRP1 expression (p = 0.103). Our results indicate that reduced SFRP1 expression is found more frequently in the less well-differentiated subgroups of AML and is associated with NPM1 mutation in AML.
authors.affiliation: Department of Hematology.
authors.forename: Cui
authors.initials: C
authors.lastname: An
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Xiang-mei
authors.initials: XM
authors.lastname: Wen
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Zhu
authors.forename: Jia-yu
authors.initials: JY
authors.lastname: Yin
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Ji-chun
authors.initials: JC
authors.lastname: Ma
authors.forename: Zhao-qun
authors.initials: ZQ
authors.lastname: Deng
authors.forename: Jiang
authors.initials: J
authors.lastname: Lin
authors.forename: Jun
authors.initials: J
authors.lastname: Qian
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009367:Neoplasm Staging; D000090243:Nucleophosmin; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction / Q000379:methods; D015996:Survival Rate; D055815:Young Adult; D000094742:Secreted Frizzled-Related Proteins
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D000090243:Nucleophosmin; C000716967:NPM1 protein, human; C117636:SFRP1 protein, human; D000094742:Secreted Frizzled-Related Proteins
keywords: NPM1 mutation; SFRP1; acute myeloid leukemia