title: Does chronic rhinosinusitis increase the risk of lung cancer? A population cohort study.
abstract: OBJECTIVE
  Chronic rhinosinusitis is one of the most common chronic inflammatory diseases of the upper airway. A previous study of chronic rhinosinusitis and the risks of lung cancer was based on a self-reported questionnaire concerning rhinosinusitis. Population-based cohort studies of the correlation between chronic rhinosinusitis and the adenocarcinoma subtype of lung cancer have been limited.
  
  
  OBJECTIVE
  In the present study, we used a population-based database to investigate the risks related to the adenocarcinoma subtype of lung cancer among patients with chronic rhinosinusitis.
  
  
  METHODS
  We identified 13 072 patients who were diagnosed with chronic rhinosinusitis in 1998-2010 as the exposure group. There were 52 288 randomly selected patients as the comparison cohort. We used data from the Taiwan National Health Insurance Research Database; the Taiwan National Health Insurance programme offers health-care services to 99% of the 23 million people residing in Taiwan. We compared the incidence of the adenocarcinoma subtype of lung cancer between the two cohorts. The cumulative incidence and hazard ratios of developing the adenocarcinoma subtype of lung cancer were calculated.
  
  
  RESULTS
  This study included 13 072 participants with chronic rhinosinusitis and 52 288 participants with non-chronic rhinosinusitis. The risk of the adenocarcinoma subtype of lung cancer was higher in the chronic rhinosinusitis cohort than in the non-chronic rhinosinusitis cohort, with an adjusted hazard ratio of 3.52 after controlling for age and gender.
  
  
  CONCLUSIONS
  This large population-based cohort study demonstrated that patients in Taiwan with previous chronic rhinosinusitis are at greater risk of developing the adenocarcinoma subtype of lung cancer.
authors.affiliation: Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Teik-Ying
authors.initials: TY
authors.lastname: Ng
authors.affiliation: Department of Health Services Administration, China Medical University, Taichung, Taiwan.
authors.forename: Kuang-Hua
authors.initials: KH
authors.lastname: Huang
authors.affiliation: Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, China Medical University, Taichung, Taiwan.
authors.forename: Ming-Hsui
authors.initials: MH
authors.lastname: Tsai
authors.affiliation: Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.|School of Medicine, China Medical University, Taichung, Taiwan.|Department of Health Services Administration, China Medical University, Taichung, Taiwan.
authors.forename: Chih-Jaan
authors.identifier: http://orcid.org/0000-0002-8000-2350
authors.initials: CJ
authors.lastname: Tai
authors.affiliation: Department of Pharmacy, Changhua Christian Hospital, Chang Hua, Taiwan.
authors.forename: Yon-Keat
authors.initials: YK
authors.lastname: Ng
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology*; D015331:Cohort Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology*; D008297:Male; D016016:Proportional Hazards Models; D012220:Rhinitis / Q000453:epidemiology*; D012307:Risk Factors; D057566:Self Report; D012852:Sinusitis / Q000453:epidemiology*; D013624:Taiwan / Q000453:epidemiology
keywords: adenocarcinoma; chronic rhinosinusitis; cohort study; lung cancer; risk