title: Feasibility study on photoacoustic guidance for high-intensity focused ultrasound-induced hemostasis.
abstract: The feasibility of photoacoustic imaging (PAI) application was evaluated to map punctured blood vessels thermally treated by high-intensity focused ultrasound (HIFU) for hemostasis. A single-element HIFU transducer with a central frequency of 2.0 MHz, was used to induce thermal hemostasis on the punctured arteries. The HIFU-treated lesion was imaged and localized by high-contrast PAI guidance. The results showed that complete hemostasis was achieved after treatment of the damaged blood vessels within 25 to 52 s at the acoustic intensity of 3600  W/cm 2 . The coagulation time for the animal artery was ∼20% longer than that of the phantom possibly due to a lower Young’s modulus. The reconstructed PA images were able to distinguish the treated area from the surrounding tissue in terms of augmented signal amplitudes (up to three times). Spectroscopic studies demonstrated that the optimal imaging wavelength was found to be 700 nm in order to reconstruct high-contrast photoacoustic images on HIFU-treated lesions. The proposed PAI integrated with HIFU treatment can be a feasible application to obtain safe and rapid hemostasis for acute arterial bleeding.
authors.affiliation: Pukyong National University, Interdisciplinary Program of Marine-Bio, Department of Electrical and Mechanical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea.
authors.forename: Van Phuc
authors.initials: VP
authors.lastname: Nguyen
authors.affiliation: Kyungpook National University, School of Electrical Engineering and Computer Science, 80 Daehakro, Bukgu, Daegu 702-701, Republic of Korea.
authors.forename: Jeehyun
authors.initials: J
authors.lastname: Kim
authors.affiliation: Pukyong National University, Department of Physics, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of Korea.
authors.forename: Kang-Lyeol
authors.initials: KL
authors.lastname: Ha
authors.affiliation: Pukyong National University, Interdisciplinary Program of Marine-Bio, Department of Electrical and Mechanical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of KoreadPukyong National University, Center for Marine-Integrated Biomedical Technolo.
authors.forename: Junghwan
authors.initials: J
authors.lastname: Oh
authors.affiliation: Pukyong National University, Interdisciplinary Program of Marine-Bio, Department of Electrical and Mechanical Engineering, 45 Yongso-ro, Nam-Gu, Busan 608-737, Republic of KoreadPukyong National University, Center for Marine-Integrated Biomedical Technolo.
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Kang
mesh_terms: D000818:Animals; D002645:Chickens; D005240:Feasibility Studies; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery; D006489:Hemostatic Techniques; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D014463:Ultrasonography