title: Stem cell niche irradiation in glioblastoma: providing a ray of hope?
abstract: Glioblastomas are organized hierarchically with a small number of glioblastoma stem cells that have unique self-renewal capacity and multilineage potency. The subventricular zone (SVZ) constitutes the largest neural stem cell niche in the adult human brain; it may also act as a reservoir of glioblastoma stem cells that can initiate, promote or repopulate a tumor. Incidental irradiation of SVZ has been shown to potentially influence outcomes suggesting that aggressively targeting the stem cell niche may offer a ray of hope in glioblastoma. The following review provides a summary of the experimental evidence supporting the origin and location of the putative glioblastoma stem cell in the SVZ, and offers a critical appraisal of the growing body of clinical evidence correlating SVZ dosimetry with outcomes in glioblastoma.
authors.affiliation: Department of Radiation Oncology, ACTREC, Tata Memorial Centre, Kharghar, Navi Mumbai 410210, India.
authors.forename: Tejpal
authors.initials: T
authors.lastname: Gupta
authors.forename: Vimoj
authors.initials: V
authors.lastname: Nair
authors.forename: Rakesh
authors.initials: R
authors.lastname: Jalali
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D002465:Cell Movement / Q000502:physiology / Q000528:radiation effects; D005909:Glioblastoma / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000502:physiology / Q000528:radiation effects*; D055153:Stem Cell Niche / Q000502:physiology / Q000528:radiation effects*
keywords: glioblastoma; invasion; migration; radiotherapy; stem cell niche; subventricular zone