title: Genetic polymorphisms in VIR genes among Indian Plasmodium vivax populations.
abstract: The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
authors.affiliation: National Institute of Malaria Research, Sector-8 Dwarka, New Delhi-110077, India.
authors.forename: Purva
authors.initials: P
authors.lastname: Gupta
authors.affiliation: Department of Biotechnology, Kumaun University, Nainital, Uttarakhand, 263001, India.
authors.forename: Veena
authors.initials: V
authors.lastname: Pande
authors.affiliation: National Institute of Malaria Research, Sector-8 Dwarka, New Delhi-110077, India.
authors.forename: Aparup
authors.initials: A
authors.lastname: Das
authors.affiliation: National Institute of Malaria Research, Sector-8 Dwarka, New Delhi-110077, India.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Singh
mesh_terms: D000953:Antigens, Protozoan / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D016780:Malaria, Vivax / Q000453:epidemiology / Q000469:parasitology; D010802:Phylogeny; D010966:Plasmodium vivax / Q000235:genetics*; D011110:Polymorphism, Genetic; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000953:Antigens, Protozoan; D015800:Protozoan Proteins
keywords: DNA sequence polymorphism; India; Plasmodium vivax; vir gene