title: Assessment of type II diabetes mellitus using irregularly sampled measurements with missing data.
abstract: Diabetes mellitus is one of the leading diseases in the developed world. In order to better regulate blood glucose in a diabetic patient, improved modelling of insulin-glucose dynamics is a key factor in the treatment of diabetes mellitus. In the current work, the insulin-glucose dynamics in type II diabetes mellitus can be modelled by using a stochastic nonlinear state-space model. Estimating the parameters of such a model is difficult as only a few blood glucose and insulin measurements per day are available in a non-clinical setting. Therefore, developing a predictive model of the blood glucose of a person with type II diabetes mellitus is important when the glucose and insulin concentrations are only available at irregular intervals. To overcome these difficulties, we resort to online sequential Monte Carlo (SMC) estimation of states and parameters of the state-space model for type II diabetic patients under various levels of randomly missing clinical data. Our results show that this method is efficient in monitoring and estimating the dynamics of the peripheral glucose, insulin and incretins concentration when 10, 25 and 50% of the simulated clinical data were randomly removed.
authors.affiliation: Chemical and Biological Engineering Department, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada, mbarazandegan@chbe.ubc.ca.
authors.forename: Melissa
authors.initials: M
authors.lastname: Barazandegan
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ekram
authors.forename: Ezra
authors.initials: E
authors.lastname: Kwok
authors.forename: Bhushan
authors.initials: B
authors.lastname: Gopaluni
authors.forename: Aditya
authors.initials: A
authors.lastname: Tulsyan
mesh_terms: D001499:Bayes Theorem; D001786:Blood Glucose / Q000032:analysis; D002986:Clinical Trials as Topic; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D054795:Incretins / Q000097:blood; D007328:Insulin / Q000097:blood; D008962:Models, Theoretical; D009010:Monte Carlo Method; D011237:Predictive Value of Tests; D011336:Probability; D013269:Stochastic Processes; D014018:Tissue Distribution
chemical_list: D001786:Blood Glucose; D054795:Incretins; D007328:Insulin