title: Ontogeny of intestinal epithelial innate immune responses.
abstract: Emerging evidence indicates that processes during postnatal development might significantly influence the establishment of mucosal host-microbial homeostasis. Developmental and adaptive immunological processes but also environmental and microbial exposure early after birth might thus affect disease susceptibility and health during adult life. The present review aims at summarizing the current understanding of the intestinal epithelial innate immune system and its developmental and adaptive changes after birth.
authors.affiliation: Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School , Hannover , Germany ; Institute of Medical Microbiology, RWTH University , Aachen , Germany.
authors.forename: Mathias W
authors.initials: MW
authors.lastname: Hornef
authors.affiliation: Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School , Hannover , Germany.
authors.forename: Marcus
authors.initials: M
authors.lastname: Fulde
keywords: antimicrobial peptide; development; infection; inflammation; innate immunity; mucosal immunology; neonate; pattern recognition receptor