title: Mutations of class II MHC molecules.
abstract: It remains unclear how the tertiary interaction of T-cell receptor, la molecule and foreign antigen results in the extensive diversity of the helper T cell repertoire. Here Laurie Glimcher and Irwin Griffith focus on what has been learned about the relationship between structure and function of the la molecule from the use of mouse strains with mutations in the genes coding for these glycoproteins.
authors.affiliation: Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: L H
authors.initials: LH
authors.lastname: Glimcher
authors.affiliation: Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: I J
authors.initials: IJ
authors.lastname: Griffith