title: A new norsesquiterpenoid from Ligularia virgaurea.
abstract: A new eremophilane norsesquiterpenoid (1), together with a known eremophilane sesquiterpenoid (2), was isolated from the leaves of Ligularia virgaurea. The structure of 1 was elucidated by a combination of spectroscopic analysis (IR, 1D NMR, 2D NMR, and HR-ESI-MS), and its absolute configuration was determined by a single-crystal X-ray diffraction experiment (with copper radiation). The known compound 2 was identified by comparison of its physical and spectral data with those reported in the literature. Compound 1 was assayed for its cytotoxic activities against human cervical carcinoma cell (HeLa) and human small cell lung cancer cell (NCI-446) lines.
authors.affiliation: a School of Pharmacy, Lanzhou University , Lanzhou 730000 , China.
authors.forename: Le-Le
authors.initials: LL
authors.lastname: Dong
authors.forename: Hui-Yan
authors.initials: HY
authors.lastname: Xiong
authors.forename: Feng-Ming
authors.initials: FM
authors.lastname: Qi
authors.forename: Hui-Hong
authors.initials: HH
authors.lastname: Li
authors.forename: Gai-Xia
authors.initials: GX
authors.lastname: Fan
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Che
authors.forename: Ding-Ding
authors.initials: DD
authors.lastname: Guo
authors.forename: Zhan-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Fei
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C000598820:(4S,5S)-9-hydroxy-6,9-diene-8-oxoeremophil-12-nor-11-ketone; D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes
keywords: Ligularia virgaurea; compositae; cytotoxic activity; eremophilane; norsesquiterpenoid