title: Diketopyrrolopyrrole-porphyrin conjugates with high two-photon absorption and singlet oxygen generation for two-photon photodynamic therapy.
abstract: Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.
authors.affiliation: LSAMM, Institut de Chimie de Strasbourg, CNRS/UMR 7177, 4 rue Blaise Pascal, 67000 Strasbourg (France).
authors.forename: Julie
authors.initials: J
authors.lastname: Schmitt
authors.forename: Valérie
authors.initials: V
authors.lastname: Heitz
authors.forename: Angélique
authors.initials: A
authors.lastname: Sour
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bolze
authors.forename: Hussein
authors.initials: H
authors.lastname: Ftouni
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Nicoud
authors.forename: Lucia
authors.initials: L
authors.lastname: Flamigni
authors.forename: Barbara
authors.initials: B
authors.lastname: Ventura
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D004396:Coloring Agents / Q000737:chemistry* / Q000494:pharmacology; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D010778:Photochemotherapy; D017785:Photons; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry* / Q000494:pharmacology; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D004396:Coloring Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; D011758:Pyrroles; D026082:Singlet Oxygen
keywords: diketopyrroles; dyes/pigments; photodynamic therapy; porphyrins; singlet oxygen; two-photon absorption