title: [Proarrhythmic effects of domperidone in infants: a systematic review].
abstract: OBJECTIVE
  To assess the association of the use of domperidone in infants with QTc interval prolongation and proarrhythmic events.
  
  
  METHODS
  A systematic search of the scientific literature was conducted without any date or language restriction. The electronic database MEDLINE and the sources LILACS, ScIELO and Cochrane library were consulted.
  
  
  RESULTS
  From the twelve identified studies, eight were excluded because they did not meet the inclusion criteria. One case report and three pilot studies were selected. Rocha et al (2005) reported the case of an infant (age 3 months) with QTc interval = 463 ms after being treated during one month with 1.8 mg/kg/day of oral domperidone. Djeddi et al (2008) administered an average dose of 1.3 mg/kg/day to 31 neonates; QTc interval prolongation > 30 ms was observed in nine neonates. Hegar et al (2009) studied 10 infants (mean age 5.6 months) who received 0.8 mg/ kg/day of oral domperidone; QTc interval prolongation was not observed. Günlemez et al (2010) enrolled 40 premature infants who were administered 1 mg/kg/day of oral domperidone; the QTc interval increased to above 450 ms in two infants.
  
  
  CONCLUSIONS
  Although evidence that orally administrated domperidone in infants produces prolongation of QTc interval was found, further studies are needed in order to quantify the risk associated with the drug in that population. We suggest that heath professionals should conduct ECGs to infants treated with domperidone and inform the pharmacovigilance system the occurrence of any case of adverse event.
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Lucía
authors.initials: L
authors.lastname: Caraballo
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Molina
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Darío
authors.initials: D
authors.lastname: Weitz
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Piskulic
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Aylén
authors.initials: A
authors.lastname: Avila
authors.affiliation: Departamento de Matemática y Estadística, Facultad de Ciencias Bioquímicas y Farmacéuticas. Universidad Nacional de Rosario. Argentina.. marzimarta58@gmail.com.
authors.forename: Marta
authors.initials: M
authors.lastname: Marzi
mesh_terms: D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001281:Atrial Fibrillation / Q000139:chemically induced; D020117:Cisapride / Q000494:pharmacology / Q000627:therapeutic use; D000075202:Contraindications; D051544:Cytochrome P-450 CYP3A / Q000502:physiology; D004294:Domperidone / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced; D008133:Long QT Syndrome / Q000139:chemically induced; D010865:Pilot Projects; D011446:Prospective Studies
chemical_list: D018492:Dopamine Antagonists; D004294:Domperidone; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D020117:Cisapride