title: Chromosome-mediated multidrug resistance in Salmonella enterica serovar Typhi.
abstract: A salmonella genomic island, designated SGI11, was found in 18 of 26 multidrug-resistant Salmonella enterica serovar Typhi isolates from Bangladesh. SGI11 was an IS1 composite transposon and carried 7 resistance genes that conferred resistance to 5 first-line antimicrobials. Eleven of the 18 SGI11-carrying S. Typhi isolates had developed resistance to high levels of ciprofloxacin.
authors.affiliation: Centers for Disease Control, Taichung, Taiwan nipmcsc@cdc.gov.tw.
authors.forename: Chien-Shun
authors.identifier: http://orcid.org/0000-0003-3674-1030
authors.initials: CS
authors.lastname: Chiou
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
authors.forename: Munirul
authors.initials: M
authors.lastname: Alam
authors.affiliation: Centers for Disease Control, Taichung, Taiwan.
authors.forename: Jung-Che
authors.initials: JC
authors.lastname: Kuo
authors.affiliation: Centers for Disease Control, Taichung, Taiwan.
authors.forename: Yen-Yi
authors.initials: YY
authors.lastname: Liu
authors.affiliation: Centers for Disease Control, Taichung, Taiwan.
authors.forename: Pei-Jen
authors.initials: PJ
authors.lastname: Wang
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001459:Bangladesh / Q000453:epidemiology; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004251:DNA Transposable Elements / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D012485:Salmonella typhi / Q000187:drug effects* / Q000235:genetics; D014435:Typhoid Fever / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D004251:DNA Transposable Elements