title: Agaricus bisporus attenuates dextran sulfate sodium-induced colitis.
abstract: Agaricus bisporus (white button mushroom, WBM) is widely consumed in most countries and is reported to have anti-inflammatory and antioxidant activities. However, little is known regarding its effects in dextran sulfate sodium (DSS)-induced colitis, which are related to dysfunction of intestinal immunity. The aim of the present study was to investigate the effects of WBMs in an animal model of DSS-induced colitis. Male, 4-week-old ICR mice (n=10 per group) were fed a normal diet with or without 10% WBM for 4 weeks, and colitis was induced by 3% DSS in drinking water for 7 days. WBMs prevented DSS-induced shortening of colon length (P=.033) and diminished diarrhea (P=.049) and gross bleeding (P=.001), resulting in a decreased disease activity index. Results of histological analysis showed that WBMs suppressed mucosal damage. In addition, WBMs attenuated the DSS-induced increase in myeloperoxidase activity (P=.012) and upregulation of proinflammatory cytokine tumor necrosis factor-α (P=.020) in the colon segment. Taken together, these findings suggest a possible role for the WBM as an immunomodulator that can prevent and/or treat ulcerative colitis.
authors.affiliation: Metabolism and Nutrition Research Group, Korea Food Research Institute , Seongnam, South Korea .
authors.forename: Min Young
authors.initials: MY
authors.lastname: Um
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Park
authors.forename: So Young
authors.initials: SY
authors.lastname: Gwon
authors.forename: Jiyun
authors.initials: J
authors.lastname: Ahn
authors.forename: Chang Hwa
authors.initials: CH
authors.lastname: Jung
authors.forename: Tae Youl
authors.initials: TY
authors.lastname: Ha
mesh_terms: D000364:Agaricus; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy*; D016207:Cytokines / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D016264:Dextran Sulfate
keywords: Agaricus bisporus; colitis; dextran sulfate sodium; inflammation