title: Mechanisms and treatments of photoaging.
abstract: Photoaging is frequently encountered in a dermatologic practice. This systematic literature review aims to explore the etiology of photoaging and address the evidence behind its current management. A comprehensive search of MEDLINE, EMBASE, UpToDate, and the Cochrane Library was conducted. Articles were limited to those relating to photoaging. There are two major approaches in the current management of photoaging. This includes strategies to prevent against ultraviolet damage (e.g. sunscreen) and medications that attempt to reverse existing skin damage (topical retinoids and 5-fluorouracil). There has been a large growth in the variety of treatment options in recent years. While it is important for such growth to continue, prevention via sensible photoprotection methods still remains the best current management option.
authors.affiliation: Department of Dermatology, Royal Melbourne Hospital, Melbourne, VIC, Australia; Department of Dermatology, Johns Hopkins Hospital, Baltimore, MD, USA.
authors.forename: Flora
authors.initials: F
authors.lastname: Poon
authors.forename: Sewon
authors.initials: S
authors.lastname: Kang
authors.forename: Anna L
authors.initials: AL
authors.lastname: Chien
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D012176:Retinoids / Q000627:therapeutic use*; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D007166:Immunosuppressive Agents; D012176:Retinoids; D005472:Fluorouracil
keywords: photoaging; photoprotection; treatment