title: The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction.
abstract: OBJECTIVE
  Uric acid (UA) is a strong marker of cardiovascular disease. Therefore, we aimed to determine the relationship between serum UA levels and cardiovascular events in patients in the early period of their acute myocardial infarction.
  
  
  METHODS
  This retrospective study included 586 consecutive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012. The study population was divided into two groups; the first group included hyperuricemic patients (n=107; uric acid level >6 mg/dl in women and >7 mg/dl in men), and the second group included patients with normal UA level (n=479). Multivariate analysis was used to demonstrate the predictive value of UA levels in groups.
  
  
  RESULTS
  Patients in the hyperuricemic group were older (median 66 years vs. 60 years, p=0.001), and the ratio of female patients was higher (35.5% vs. 16.9%, p=0.001). Patients with hyperuricemia had a significantly higher incidence of in-hospital cardiovascular mortality than the normal group (15.9% vs. 3.1%, p<0.001). Advanced heart failure (class ≥ 3) was more frequent among hyperuricemic patients (17.8% vs. 8.8%, p=0.006). Age ≥ 70 years, chest pain duration >6 hours and hyperuricemia (hazard ratio (HR): 1.83, 95% confidence interval: 1.02-3.27; p=0.041) were found to be independent predictors of advanced heart failure. Hyperuricemia was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (HR: 5.32, 95% confidence interval: 2.46-11.49; p=0.001).
  
  
  CONCLUSIONS
  This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and morbidity during the in-hospital period of STEMI.
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey. eordulu@hotmail.com.
authors.forename: Emine
authors.initials: E
authors.lastname: Gazi
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temiz
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Burak
authors.initials: B
authors.lastname: Altun
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Barutçu
authors.affiliation: Department of Cardiology, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Bekler
authors.affiliation: Department of Cardiology, Çanakkale State Hospital, Çanakkale, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Güngör
authors.affiliation: Department of Cardiovascular Surgery, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Ali Umit
authors.initials: AU
authors.lastname: Yener
authors.affiliation: Department of Cardiovascular Surgery, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Tolga
authors.initials: T
authors.lastname: Kurt
authors.affiliation: Department of Cardiovascular Surgery, Çanakkale Onsekiz Mart University Faculty of Medicine, Çanakkale, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Ozcan
authors.affiliation: Department of Cardiology, Çanakkale State Hospital, Çanakkale, Turkey.
authors.forename: Sabri
authors.initials: S
authors.lastname: Gazi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006333:Heart Failure / Q000097:blood / Q000401:mortality*; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000401:mortality*; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid