title: Shape-parameterized diffuse optical tomography holds promise for sensitivity enhancement of fluorescence molecular tomography.
abstract: A fundamental approach to enhancing the sensitivity of the fluorescence molecular tomography (FMT) is to incorporate diffuse optical tomography (DOT) to modify the light propagation modeling. However, the traditional voxel-based DOT has been involving a severely ill-posed inverse problem and cannot retrieve the optical property distributions with the acceptable quantitative accuracy and spatial resolution. Although, with the aid of an anatomical imaging modality, the structural-prior-based DOT method with either the hard- or soft-prior scheme holds promise for in vivo acquiring the optical background of tissues, the low robustness of the hard-prior scheme to the segmentation error and inferior performance of the soft-prior one in the quantitative accuracy limit its further application. We propose in this paper a shape-parameterized DOT method for not only effectively determining the regional optical properties but potentially achieving reasonable structural amelioration, lending itself to FMT for comparably improved recovery of fluorescence distribution.
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Linhui
authors.initials: L
authors.lastname: Wu
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Wan
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China ; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Zhou
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China ; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China ; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Limin
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China ; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Huijuan
authors.initials: H
authors.lastname: Zhao
authors.affiliation: College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China ; Tianjin Key Laboratory of Biomedical Detecting Techniques and Instruments, Tianjin 300072, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
keywords: (170.3010) Image reconstruction techniques; (170.3880) Medical and biological imaging; (170.6960) Tomography