title: Executive testing predicts functional loss in subjects with white matter lesions.
abstract: In order to assess ecological validity of executive function (EF) tests and the impact of EF dysfunction on functional status in elderly subjects with moderate and severe subcortical white matter hyperintensities (WMHs), we made a correlation analysis between EF scores and two measures of Instrumental Activities of Daily Living (IADL). Trail-making test and CLOX correlated with the ability to perform IADL in subjects with severe WMH. EF tests might present low ecological validity for those with WMH below severe stage.
authors.affiliation: a Center for Subjects with Alzheimer's Disease and Related Disorders, Institute of Psychiatry, Federal University of Rio de Janeiro (CDA/IPUB/UFRJ) , Rio de Janeiro , Brazil.
authors.forename: Felipe Kenji
authors.initials: FK
authors.lastname: Sudo
authors.forename: Gilberto Sousa
authors.initials: GS
authors.lastname: Alves
authors.forename: Letice
authors.initials: L
authors.lastname: Ericeira-Valente
authors.forename: Carlos Eduardo Oliveira
authors.initials: CE
authors.lastname: Alves
authors.forename: Chan
authors.initials: C
authors.lastname: Tiel
authors.forename: Denise Madeira
authors.initials: DM
authors.lastname: Moreira
authors.forename: Jerson
authors.initials: J
authors.lastname: Laks
authors.forename: Eliasz
authors.initials: E
authors.lastname: Engelhardt
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001921:Brain / Q000473:pathology*; D002545:Brain Ischemia / Q000473:pathology* / Q000523:psychology; D003430:Cross-Sectional Studies; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D014652:Vascular Diseases / Q000473:pathology* / Q000523:psychology; D066127:White Matter / Q000473:pathology*
keywords: cerebrovascular disorders; executive function; neuroimaging; neuropsychology; vascular dementia