title: In vitro study and characterization of doxorubicin-loaded magnetic nanoparticles modified with biodegradable copolymers.
abstract: Magnetic nanoparticles are a main class of nanoscale materials with the potential to revolutionize present clinical therapeutic and diagnostic techniques. Functionalization of magnetic nanoparticles with copolymers, different surfactants, or other organic compounds is usually done in order to achieve better physicochemical properties. Poly (D,L-lactic-co-glycolic acid) (PLGA) polymers have been extensively used as biodegradable carriers for drug delivery. These biodegradable aliphatic polyesters, with proven biocompatibility, have versatile biodegradation properties, depending on their molecular weight and chemical composition. The aim of the present work was to assess the merits of Fe3 O4-PLGA-PEG nanoparticles as anticancer drug carriers. For this purpose, magnetic Fe3O4 nanoparticles were first prepared, and then the copolymer PLGA-PEG was synthesized with polyethylene glycol (PEG) of various molecular weights. The copolymer was conﬁrmed with Fourier transform infrared (FTIR) spectra. Doxorubicin was encapsulated within nanoparticles made of Fe3O4-PLGA-PEG, using the double emulsion method (w/o/w). The nanoparticles were characterized in terms of size, and the in vitro release of doxorubicin.
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Eommolbanin
authors.initials: E
authors.lastname: Ebrahimi
authors.affiliation: b Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Amir Ahmad
authors.initials: AA
authors.lastname: Khandaghi
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Valipour
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Soraia
authors.initials: S
authors.lastname: Babaie
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Asghari
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Soheila
authors.initials: S
authors.lastname: Motaali
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Elham
authors.initials: E
authors.lastname: Abbasi
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: a Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz 5154853431 , Iran.
authors.forename: Soodabeh
authors.initials: S
authors.lastname: Davaran
mesh_terms: D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D065546:Drug Liberation; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008970:Molecular Weight; D011092:Polyethylene Glycols / Q000737:chemistry; D011100:Polyglycolic Acid / Q000737:chemistry* / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: biodegradable; doxorubicin; magnetic nanoparticles; poly (D,L-lactic-co-glycolic acid)