title: Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma.
abstract: There is substantial controversy regarding the causative role of amyloid β (Aβ) deposition in Alzheimer's disease (AD). The cerebrovasculature plays an important role in the elimination of Aβ from the brain and hypertension is a well-known risk factor for AD. In spontaneously hypertensive stroke-prone rats (SHRSP), an animal model of chronic arterial hypertension, cerebral small vessel disease (CSVD) leads to age-dependent parenchymal Aβ accumulation similar to that observed in AD. These data approve the neuropathological link between CSVD and AD, confirm the challenge that parenchymal Aβ deposition is a specific marker for AD and disclose the meaning of SHRSP as valid experimental model to investigate the association between hypertension, CSVD, and Aβ plaques.
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
authors.forename: Celine Z
authors.initials: CZ
authors.lastname: Bueche
authors.affiliation: Faculty of Medicine, University of Southampton Southampton, United Kingdom.
authors.forename: Cheryl
authors.initials: C
authors.lastname: Hawkes
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Garz
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Vielhaber
authors.affiliation: Institute for Aging and Health, Newcastle University Newcastle, United Kingdom.
authors.forename: Johannes
authors.initials: J
authors.lastname: Attems
authors.affiliation: Helen Wills Neuroscience Institute and Department of Psychology, University of California Berkeley, California.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Knight
authors.affiliation: German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
authors.forename: Klaus
authors.initials: K
authors.lastname: Reymann
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
authors.forename: Hans-Jochen
authors.initials: HJ
authors.lastname: Heinze
authors.affiliation: Faculty of Medicine, University of Southampton Southampton, United Kingdom.
authors.forename: Roxana O
authors.initials: RO
authors.lastname: Carare
authors.affiliation: Department of Neurology, Otto-von-Guericke University Magdeburg, Germany ; German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Schreiber