title: TiF4-mediated regioselective cycloaddition of 2-(trifluoromethyl)-N-tosylaziridine to nitriles.
abstract: We report the first [3 + 2] cycloaddition of 2-(trifluoromethyl)-N-tosylaziridine to nitriles using TiF4 as an effective Lewis acid under mild reaction conditions. The reaction proceeded smoothly and afforded the corresponding 4-(trifluoromethyl)-1,3-imidazolines in good yields and with excellent regioselectivity.
authors.affiliation: Department of Chemistry and Applied Chemistry, Saga University , Honjyo-machi 1, Saga 840-8502, Japan.
authors.forename: Michiya
authors.initials: M
authors.lastname: Yoshiki
authors.forename: Rie
authors.initials: R
authors.lastname: Ishibashi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Yamada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hanamoto