title: Curcumin as a protector for normal cells during bortezomib therapy.
abstract: This study evaluated the protective potential of curcumin on the possible side effects of bortezomib (Bt) therapy on normal cells in mice. The mice were segregated into three groups (n = 10) that included normal control, Bt-treated, and Bt + curcumin-treated groups. The Bt treatment resulted in significant decrease in the enzyme activity of erythrocyte δ-aminolevulinic acid dehydratase (ALAD). Also a significant decrease in the hemoglobin (Hb) was also noticed. On the other hand, curcumin co-treatment improvised enzyme activity of erythrocyte ALAD as well as Hb values. The study, therefore, concludes that curcumin co-treatment with Bt has a potential to take care of possible side effects of Bt therapy on normal cells.
authors.affiliation: Department of Biophysics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: R R
authors.initials: RR
authors.lastname: Kumar
authors.affiliation: Department of Biophysics, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India anshoo.malhotra@gmail.com.
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000069286:Bortezomib / Q000009:adverse effects* / Q000627:therapeutic use; D003474:Curcumin / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D051379:Mice; D000623:Porphobilinogen Synthase / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D006454:Hemoglobins; D020011:Protective Agents; D000069286:Bortezomib; D000623:Porphobilinogen Synthase; D003474:Curcumin
keywords: Drug toxicology; cancer biology; oxidative stress