title: Refractory bullous pemphigoid leaving numerous milia during recovery.
abstract: Recovery with milia may occur in bullous pemphigoid (BP), mucous membrane pemphigoid (MMP) and epidermolysis bullosa acquisita (EBA). Scarring commonly occurs in MMP and EBA. Here, we report a 62-year-old man patient with BP, who was left with numerous milia during recovery. The patient had immunoglobulin (Ig)G autoantibodies to the recombinant protein of the BP180-NC16a domain and the soluble 120-kDa ectodomain of BP180 (linear IgA bullous dermatosis [LAD]-1). There are cases of BP with IgG autoantibodies to LAD-1 and/or the recombinant protein of BP180 C-terminal domain. Extensive milia formation during recovery may be associated with immunological predisposition and/or improper interaction between hemidesmosomes and the extracellular matrix components.
authors.affiliation: Department of Dermatology, Kinki University Faculty of Medicine, Osaka-Sayama, Japan.
authors.forename: Shusuke
authors.initials: S
authors.lastname: Uchida
authors.forename: Naoki
authors.initials: N
authors.lastname: Oiso
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koga
authors.forename: Norito
authors.initials: N
authors.lastname: Ishii
authors.forename: Kazunori
authors.initials: K
authors.lastname: Okahashi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Matsuda
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Akira
authors.initials: A
authors.lastname: Kawada
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D010391:Pemphigoid, Bullous / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000473:pathology*
keywords: BP180-NC16a domain; bullous pemphigoid; epidermolysis bullosa acquisita; linear immunoglobulin A bullous dermatosis-1; milium; mucous membrane pemphigoid