title: Polymorphism in IFI16 affects CD4(+) T-cell counts in HIV-1 infection.
abstract: Interferon-γ-inducible protein 16 (IFI16) plays a pivotal role in the death of bystander CD4(+) T-cells. Here, we demonstrate that SNP rs1417806 in IFI16 is associated with CD4(+) T-cell counts at set point and HIV-1 disease progression, indicating that IFI16 affects HIV-1 pathogenesis especially during the early phase of infection.
authors.affiliation: Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory and Center for Infection and Immunity (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Booiman
authors.forename: N A
authors.initials: NA
authors.lastname: Kootstra
mesh_terms: D000483:Alleles; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019562:Viral Load
chemical_list: D009687:Nuclear Proteins; D010750:Phosphoproteins; C076700:IFI16 protein, human