title: Preparation and enantioseparation characteristics of a novel β-cyclodextrin derivative chiral stationary phase in high-performance liquid chromatography.
abstract: A novel cyclodextrin (CD) derivative mono(6(A)-N-allylamino-6(A)-deoxy)per-3-chlorine-4-methyl-phenylcarbamoylated-β-CD was synthesized and chemically immobilized onto the surface of γ-mercaptopropyl-functionalized silica gel step by step. The products were all purified and characterized and then got a substance with definitional structure. This chiral stationary phase (CSP) of 3-chlorine-4-methyl-phenylcarbamoylated-β-CD bonded on silica gel exhibited excellent separation capability for several chiral compounds in high-performance liquid chromatography. In the enantiomeric separations of five racemates with a mixture of methanol and aqueous KH2PO4 buffer as the mobile phase, this CSP presented good chiral recognition performance.
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Pei
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Xuxia
authors.initials: X
authors.lastname: Zheng
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.
authors.forename: Suzhen
authors.initials: S
authors.lastname: Zhao
authors.affiliation: School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou, Henan 450001, P.R. China zhangzz08@126.com.
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D047392:beta-Cyclodextrins; C031215:betadex