title: Prothrombotic SERPINC1 gene polymorphism may affect heparin sensitivity among different ethnicities of Chinese patients receiving heart surgery.
abstract: The purpose of this study was to investigate a possible correlation between single-nucleotide polymorphisms (SNPs) of the antithrombin (gene, SERPINC1, and perioperative sensitivity to heparin in patients receiving heart surgery. The SERPINC1 genotype and allele frequency, coagulation parameters 24 hours before and after surgery, and clinical findings were compared among 3 ethnic groups, Han, Uighur, and Kazakh, patientswho received heart surgery. In Han patients, longer coagulation time as well as higher heparin and protamine dosage was observed. SERPINC1 gene sequencing identified 2 mutations in exon 5, g.981A>G (rs5877) and g.1011A>G (rs5878). The minor allele frequency of allele (A>G) for rs5877 and rs5878 was higher in the Han patients and was significantly different among the ethnic groups (P = .004 and P = .006, respectively). The increased SERPINC1 SNP frequency among Han patients receiving heart surgery might contribute to the differences in their perioperative sensitivity to heparin.
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Ai Lai Ti Ta Lai
authors.initials: AL
authors.lastname: Ti
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Zhang
authors.affiliation: Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China xjzhenghong@aliyun.com.
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000208:ethnology; D001777:Blood Coagulation / Q000187:drug effects / Q000235:genetics*; D006348:Cardiac Surgical Procedures; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D006493:Heparin / Q000008:administration & dosage*; D015844:Heparin Cofactor II / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: C047932:SERPIND1 protein, human; D015844:Heparin Cofactor II; D006493:Heparin
keywords: antithrombin; cardiopulmonary bypass; partial thromboplastin time; prothrombin time; single-nucleotide polymorphism