title: Somatosensory and auditory processing in opioid-exposed newborns with neonatal abstinence syndrome: a magnetoencephalographic approach.
abstract: OBJECTIVE
  Opioid exposure during pregnancy is a potential risk factor for the developing central nervous system of the fetus. We studied evoked responses in buprenorphine-exposed newborns who displayed neonatal abstinence syndrome (NAS) to elucidate the possible alterations in functioning of the somatosensory and auditory systems.
  
  
  METHODS
  We compared somatosensory (SEFs) and auditory evoked magnetic fields (AEFs), recorded with magnetoencephalography (MEG), of 11 prenatally buprenorphine-exposed newborns with those of 12 healthy newborns. Peak latencies, source strength and location of SEFs or AEFs were recorded.
  
  
  RESULTS
  AEFs were present in all buprenorphine-exposed newborns without significant differences from those of healthy newborns. In contrast, though no group level differences in SEFs existed, at individual level the response deviated from the typical neonatal morphology in four buprenorphine-exposed newborns.
  
  
  CONCLUSIONS
  Although buprenorphine exposure during pregnancy does not seem to cause constant deficiencies in somatosensory or auditory processing, in some newborns the typical development of somatosensory networks may be - at least transiently - disrupted.
authors.affiliation: a Department of Social Pediatrics , Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
authors.forename: K
authors.initials: K
authors.lastname: Kivistö
authors.affiliation: b BioMag Laboratory , Hospital District of Helsinki and Uusimaa, HUS Medical Imaging Center, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
authors.forename: P
authors.initials: P
authors.lastname: Nevalainen
authors.affiliation: c Department of Clinical Neurophysiology , Hospital for Children and Adolescents and University of Helsinki , Helsinki , Finland , and.
authors.forename: L
authors.initials: L
authors.lastname: Lauronen
authors.affiliation: a Department of Social Pediatrics , Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
authors.forename: S
authors.initials: S
authors.lastname: Tupola
authors.affiliation: d Brain Research Unit, O.V. Lounasmaa Laboratory , Aalto University School of Science , Espoo , Finland.
authors.forename: E
authors.initials: E
authors.lastname: Pihko
authors.affiliation: a Department of Social Pediatrics , Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki , Helsinki , Finland .
authors.forename: S
authors.initials: S
authors.lastname: Kivitie-Kallio
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects; D001306:Auditory Pathways / Q000187:drug effects / Q000503:physiopathology; D002047:Buprenorphine / Q000009:adverse effects*; D005072:Evoked Potentials, Auditory; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D015225:Magnetoencephalography; D008297:Male; D008431:Maternal-Fetal Exchange; D009357:Neonatal Abstinence Syndrome / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D020886:Somatosensory Disorders / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine
keywords: Auditory evoked magnetic field; buprenorphine; magnetoencephalography; neonatal abstinence syndrome; somatosensory evoked magnetic field