title: Investigations of sensitivity and resolution of ECG and MCG in a realistically shaped thorax model.
abstract: Solving the inverse problem of electrocardiography (ECG) and magnetocardiography (MCG) is often referred to as cardiac source imaging. Spatial properties of ECG and MCG as imaging systems are, however, not well known. In this modelling study, we investigate the sensitivity and point-spread function (PSF) of ECG, MCG, and combined ECG+MCG as a function of source position and orientation, globally around the ventricles: signal topographies are modelled using a realistically-shaped volume conductor model, and the inverse problem is solved using a distributed source model and linear source estimation with minimal use of prior information. The results show that the sensitivity depends not only on the modality but also on the location and orientation of the source and that the sensitivity distribution is clearly reflected in the PSF. MCG can better characterize tangential anterior sources (with respect to the heart surface), while ECG excels with normally-oriented and posterior sources. Compared to either modality used alone, the sensitivity of combined ECG+MCG is less dependent on source orientation per source location, leading to better source estimates. Thus, for maximal sensitivity and optimal source estimation, the electric and magnetic measurements should be combined.
authors.affiliation: Department of Biomedical Engineering and Computational Science, Aalto University, Espoo, PO Box 12200, FI-00076, AALTO, Finland. BioMag Laboratory, HUS Medical Imaging Center, Helsinki, PO Box 340, FI-00029, HUS, Finland.
authors.forename: Ville
authors.initials: V
authors.lastname: Mäntynen
authors.forename: Teijo
authors.initials: T
authors.lastname: Konttila
authors.forename: Matti
authors.initials: M
authors.lastname: Stenroos
mesh_terms: D004562:Electrocardiography / Q000379:methods*; D006321:Heart / Q000502:physiology; D006801:Humans; D053798:Magnetocardiography / Q000379:methods*; D008955:Models, Cardiovascular; D012680:Sensitivity and Specificity; D013909:Thorax / Q000502:physiology