title: Pregnancy-associated plasma protein-A and the vulnerable plaque.
abstract: For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the challenges in different assay technologies and describes the effect of heparin administration on PAPP-A concentrations in plasma.
authors.affiliation: Department of Cardiology, Nordsjællands Hospital Hillerød, Hillerød, Denmark.
authors.forename: Camilla H B
authors.initials: CH
authors.lastname: Jespersen
authors.forename: Kirstine R
authors.initials: KR
authors.lastname: Vestergaard
authors.forename: Morten
authors.initials: M
authors.lastname: Schou
authors.forename: Børge
authors.initials: B
authors.lastname: Teisner
authors.forename: Jens P
authors.initials: JP
authors.lastname: Goetze
authors.forename: Kasper
authors.initials: K
authors.lastname: Iversen
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011379:Prognosis
chemical_list: D015415:Biomarkers; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human
keywords: ACS; PAPP-A; heparin; vulnerable plaque