title: Diagnosis of HPV-negative, gastric-type adenocarcinoma of the endocervix.
abstract: Gastric-type adenocarcinoma of the cervix (GAS) is a novel, recently described subtype of endocervical adenocarcinoma. The clinical importance of accurate diagnosis of GAS stems from the observation that it confers worse prognosis than the usual-type endocervical adenocarcinoma. There are two unique characteristics of GAS: the tumor cells contain voluminous amounts of gastric-type mucins, and the tumor pathogenesis is not related to infection with high-risk human papillomavirus types. The histopathologic diagnosis of GAS is difficult; however, it may be confirmed by demonstration of intra-cytoplasmic gastric-type mucins using immunohistochemical staining with monoclonal antibody HIK1083. A protocol for HIK1083 immunostaining is described.
authors.affiliation: Department of Pathology, Weill Medical College of Cornell University, 525 E 68th Street, ST-1041, New York, NY, 10065, USA, ecpirog@med.cornell.edu.
authors.forename: Edyta C
authors.initials: EC
authors.lastname: Pirog
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000821:virology; D000956:Antigens, Viral / Q000276:immunology; D001331:Automation; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D027383:Papillomaviridae / Q000276:immunology / Q000502:physiology*; D013194:Staining and Labeling; D013270:Stomach / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000821:virology
chemical_list: D000956:Antigens, Viral; D000939:Epitopes