title: Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection.
abstract: In this study, we assessed the in vivo behavior and toxicology of nanoscale graphene oxide (NGO) in mice after intravenous injection. The influence of a polyethylene glycol (PEG) coating on the distribution and toxicity of the NGO was also investigated. The results show that NGO is mainly retained in the liver, lung, and spleen. Retention in the lung is partially due to NGO aggregation. The PEG coating reduces the retention of NGO in the liver, lung, and spleen and promotes the clearance of NGO from these organs, but NGO and NGO-PEG are still present after 3 months. The PEG coating effectively reduces the early weight loss caused by NGO and alleviates NGO-induced acute tissue injuries, which can include damage to the liver, lung, and kidney, and chronic hepatic and lung fibrosis.
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China ; Department of Human Anatomy, College of Basic Medical Sciences, Jilin University, Changchun, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Xiao-Yong
authors.initials: XY
authors.lastname: Zhang
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Jian-Zhong
authors.initials: JZ
authors.lastname: Yang
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhang
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Wen-Xin
authors.initials: WX
authors.lastname: Li
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Chun-Hai
authors.initials: CH
authors.lastname: Fan
authors.affiliation: Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000493:pharmacokinetics; D006108:Graphite / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D020099:Coated Materials, Biocompatible; D011092:Polyethylene Glycols; D006108:Graphite
keywords: biodistribution; graphene oxide; polyethylene glycol; toxicity