title: Ischemia modified albumin is an indicator of oxidative stress in multiple sclerosis.
abstract: BACKGROUND
  Oligodendrocytes need iron in processes of energy generation and myelination. However, excessive levels of iron may exert iron induced oxidative stress and thus lead to tissue degeneration. Monitoring oxidative stress will be of paramount importance in follow-up of patients with many diseases including multiple sclerosis (MS). The aim of this study was to measure total anti-oxidative status (TAS), total oxidative status (TOS) and ischemia modified albumin (IMA) in stable relapse remitting MS (RRMS) patients.
  
  
  METHODS
  Thirty-five RRMS patients (15 males and 20 females; median age 42 (20-55) years) and thirty-five age-sex matched healthy controls (13 males and 22 females; median age 37 (21-60) years) were included in this study. All patients were diagnosed with MS according to the criteria of McDonald.
  
  
  RESULTS
  IMA levels were significantly higher in RRMS patients (P < 0.001), while TAS and TOS did not show any significant difference between groups (P = 0.870 and P = 0.460, respectively).
  
  
  CONCLUSIONS
  Our results suggest IMA as a more efficient serum marker than TAS and TOS in detecting the oxidative stress in MS patients. Serum oxidative stress markers should be included in future study protocols besides clinical and radiological parameters.
authors.affiliation: Biochemistry Laboratory, Batman Maternity and Children's Hospital, Batman, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Aydin
authors.affiliation: Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Hamit Yasar
authors.initials: HY
authors.lastname: Ellidag
authors.affiliation: Biochemistry Laboratory, Antalya Public Health Center of Ministry of Health, Antalya, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Eren
authors.affiliation: Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Kurtulus
authors.affiliation: Neurology Clinic of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Aylin
authors.initials: A
authors.lastname: Yaman
authors.affiliation: Central laboratories of Antalya Education and Research Hospital of Ministry of Health, Antalya, Turkey.
authors.forename: Necat
authors.initials: N
authors.lastname: Yılmaz
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis* / Q000378:metabolism*; D018384:Oxidative Stress; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D055815:Young Adult
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D000075462:Serum Albumin, Human
keywords: ischemia-modified albumin; multiple sclerosis; oxidative stress