title: Use of a 12-week observational period for predicting low disease activity at 52 weeks in RA patients treated with abatacept: a retrospective observational study based on data from a Japanese multicentre registry study.
abstract: OBJECTIVE
  Only a few studies have assessed predictive factors for the long-term efficacy of abatacept. This study aimed to provide clinical evidence of an adequate observational period for predicting low disease activity (LDA) achievement at 52 weeks in RA patients treated with abatacept.
  
  
  METHODS
  Participants were all patients registered in a Japanese multicentre registry who were treated with abatacept and had at least 52 weeks of follow-up (n = 254).
  
  
  RESULTS
  Areas under the receiver operating characteristic curves for the 28-joint count with CRP (DAS28-CRP) at each time point for LDA achievement at 52 weeks were: 0.686 (cut-off score: 4.6) at baseline, 0.780 (3.8) at 4 weeks, 0.875 (3.3) at 12 weeks, and 0.900 (3.0) at 24 weeks. Although patients with a DAS28-CRP score < 3.0 at 24 weeks had the highest proportion of LDA achievement at 52 weeks (79.3%), the proportion for those with a score < 3.3 at 12 weeks was comparable (77.2%, P = 0.697). Proportions were significantly lower in patients with a score < 3.8 at 4 weeks or < 4.6 at baseline. Multivariate logistic regression demonstrated that a DAS28 score of < 3.3 at 12 weeks was an independent strong predictor for LDA at 52 weeks (adjusted odds ratio: 15.2, P < 0.001).
  
  
  CONCLUSIONS
  Twelve weeks is an adequate observational period to judge the long-term clinical efficacy of abatacept, and is about as early as the period for assessing TNF blockade therapy.
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan nobunori@med.nagoya-u.ac.jp.
authors.forename: Nobunori
authors.initials: N
authors.lastname: Takahashi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Kojima
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kaneko
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Daihei
authors.initials: D
authors.lastname: Kida
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hirano
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Fujibayashi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yabe
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Takagi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oguchi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Miyake
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kato
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Fukaya
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Hayashi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Tsuboi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Kanayama
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Funahashi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hanabayashi
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Hirabara
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Asai
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshioka
authors.affiliation: Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi, Japan, Department of Orthopedic Surgery and Rheumatology, Nagoya Medical Center, Naka-ku, Nagoya, Aichi, Department of Rheumatology, Toyohashi Municipal Hospital, Aotake-cho, Toyohashi, Aichi, Department of Orthopedic Surgery, Konan Kosei Hospital, Takaya-cho, Konan, Aichi, Department of Rheumatology, Tokyo Kosei Nenkin Hospital, Shinjuku-ku, Tokyo, Department of Orthopedic Surgery, Nagoya Central Hospital, Nakamura-ku, Nagoya, Aichi, Department of Orthopedic Surgery, Anjo Kosei Hospital, Anjo, Aichi, Department of Orthopedic Surgery, Ichinomiya Municipal Hospital, Bunkyo, Ichinomiya, Aichi, Kato Orthopedic Clinic, Okazaki, Aichi, Department of Orthopedic Surgery, Kariya-Toyota General Hospital, Kariya, Aichi, Department of Rheumatology, Nagano Red Cross Hospital, Nagano, Department of Orthopedic Surgery, Shizuoka Kosei Hospital, Aoi-ku, Shizuoka, Japan, and Department of Orthopedic Surgery, Toyota Kosei Hospital, Josui-cho, Toyota, Aichi, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000069594:Abatacept; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018796:Immunoconjugates / Q000627:therapeutic use*; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D018501:Antirheumatic Agents; D015415:Biomarkers; D018796:Immunoconjugates; D014409:Tumor Necrosis Factor-alpha; D000069594:Abatacept; D002097:C-Reactive Protein
keywords: Japanese; RA; abatacept; adequate observational period; long-term efficacy; multicentre registry system; predictors