title: Increased vaspin levels are associated with beneficial metabolic outcome pre- and post-bariatric surgery.
abstract: OBJECTIVE
  Vaspin (visceral-adipose-tissue-derived-serine-protease-inhibitor) is a recently identified adipokine with putative insulin-sensitizing properties. Plasma vaspin responses to surgery-induced weight loss are sparse and contradictory.
  
  
  METHODS
  We evaluated changes in vaspin levels and relationship to post-operative outcomes in men (n = 22) and women (n = 55) undergoing biliopancreatic-diversion/duodenal-switch bariatric surgery. Body composition and plasma parameters were measured at baseline, acutely (1 and 5 days) and medium-term (6 and 12 months) post-surgery.
  
  
  RESULTS
  Fasting preoperative vaspin concentrations were comparable in men vs women. The distribution was biphasic (both men and women) with a nadir of 2.5 ng/ml. Subjects were divided into high (≥2.5 ng/mL, HI-group) and low (<2.5 ng/mL, LO-group) vaspin level. Both groups had comparable sex distribution, age and BMI, but the HI-vaspin group had lower insulin, HOMA, and triglyceride and higher HDL-cholesterol, acylation stimulating protein (ASP) and IL-6 levels (all p<0.05). Post-operatively, both groups decreased BMI comparably over 12 months; the HI-vaspin group maintained high vaspin levels, while the LO-vaspin group gradually increased their levels with weight loss over 12 months. The HI-vaspin group maintained a better glucose, insulin, HOMA, fructosamine, HDL-cholesterol, and triglyceride profile throughout. The HI-vaspin group also had higher gamma-glutamyltransferase and ASP profiles. Finally, baseline vaspin level inversely correlated significantly with baseline and 12-month insulin, HOMA, triglyceride and positively correlated with HDL and ASP. Twelve-month vaspin also correlated similarly, including an inverse correlation with BMI.
  
  
  CONCLUSIONS
  Globally, this study supports the concept of vaspin as a beneficial adipokine in obesity, which may potentially lead to possible therapeutic targets.
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Department of Pediatrics, Tongji Hospital, HuaZhong University of Science and Technology, Wuhan Hubei, PR China.
authors.forename: HuiLing
authors.initials: H
authors.lastname: Lu
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Université de Yaoundé, Faculté des Sciences, Laboratoire de Nutrition et de Biochimie Nutritionnelle, Yaoundé, Cameroon.
authors.forename: Ponce Cedric
authors.initials: PC
authors.lastname: Fouejeu Wamba
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada.
authors.forename: Marc
authors.initials: M
authors.lastname: Lapointe
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Faculté de Pharmacie, Université Laval, Québec, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Poirier
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Faculté de Pharmacie, Université Laval, Québec, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Martin
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Faculté de Pharmacie, Université Laval, Québec, Canada.
authors.forename: Marjorie
authors.initials: M
authors.lastname: Bastien
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Cardiologie & Pneumologie de Quebec, Université Laval, Québec, Canada; Faculté Médecine, Université Laval, Québec, Canada.
authors.forename: Katherine
authors.initials: K
authors.lastname: Cianflone
mesh_terms: D000328:Adult; D000886:Anthropometry; D050110:Bariatric Surgery; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D057234:Preoperative Period; D015843:Serpins / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; C507339:SERPINA12 protein, human; D015843:Serpins