title: [Thrombosis of a mechanical prosthetic mitral valve during dabigatran treatment].
abstract: Dabigatran has been approved for prevention of thromboembolic complications in nonvalvular atrial fibrillation. We present a case of thrombosis of a mechanical prosthetic mitral valve during anticoagulation with dabigatran, switched from warfarin. The patient presented with cardiogenic shock, was treated with thrombolytic therapy and discharged with warfarin therapy. Dabigatran in patients with mechanical valve prosthesis should be avoided and echocardiography is indicated if dyspnoea develops in such patients.
authors.affiliation: Hjertemedicinsk Klinik B, Hjertecentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. jakob@jht.dk.
authors.forename: Jakob Hartvig
authors.initials: JH
authors.lastname: Thomsen
authors.forename: Jesper
authors.initials: J
authors.lastname: Kjaergaard
authors.forename: Laura Trolle
authors.initials: LT
authors.lastname: Saust
authors.forename: Kristian
authors.initials: K
authors.lastname: Wachtell
authors.forename: Christian
authors.initials: C
authors.lastname: Hassager
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D000991:Antithrombins / Q000009:adverse effects* / Q000627:therapeutic use; D000069604:Dabigatran / Q000009:adverse effects* / Q000627:therapeutic use; D017548:Echocardiography, Transesophageal; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000473:pathology; D012770:Shock, Cardiogenic / Q000139:chemically induced / Q000188:drug therapy; D013927:Thrombosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D014859:Warfarin; D000069604:Dabigatran