title: Protective effect of grape seed extract in experimental menopausal syndrome.
abstract: Grape seed extract (GSE) is a natural product obtained from Vitis vinifera seeds; it has been used as adjuvant therapy in wide range of pathological conditions.
  
  
  OBJECTIVE
  In the present study, we investigated the ability of GSE to improve the mental status on ovariectomized rats.
  
  
  METHODS
  GSE (10 mg/kg/day, 60 days long) was administrated orally on ovariectomized adult female rats; then the animals were investigated in open field. Additionally, were measured the hematological parameters, the plasma biochemistry, and the oxidative stress markers.
  
  
  CONCLUSIONS
  Treatment of GSE improved the loco motor activity in the open field, the number of crossings were almost twice in GSE treated rats (22.25 +/- 8.75) compared to placebo group (13.00 +/- 2.62) (p < 0.05). Lipid peroxides were reduced up to 51.57% (p < 0.05), while hematology and plasma biochemistry remained almost unchanged.
  
  
  CONCLUSIONS
  GSE improve the mental status and reduced the level of oxidative stress in rats subject to experimental ovariectomy.
authors.forename: B
authors.initials: B
authors.lastname: Sevastre
authors.forename: M
authors.initials: M
authors.lastname: Taulescu
authors.forename: I
authors.initials: I
authors.lastname: Marcus
authors.forename: Daniela
authors.initials: D
authors.lastname: Benedec
authors.forename: A
authors.initials: A
authors.lastname: Mocanu
authors.forename: Daniela
authors.initials: D
authors.lastname: Hanganu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D056604:Grape Seed Extract / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008593:Menopause / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy / Q000379:methods; D051381:Rats
chemical_list: D000975:Antioxidants; D056604:Grape Seed Extract