title: Topic modeling for cluster analysis of large biological and medical datasets.
abstract: BACKGROUND
  The big data moniker is nowhere better deserved than to describe the ever-increasing prodigiousness and complexity of biological and medical datasets. New methods are needed to generate and test hypotheses, foster biological interpretation, and build validated predictors. Although multivariate techniques such as cluster analysis may allow researchers to identify groups, or clusters, of related variables, the accuracies and effectiveness of traditional clustering methods diminish for large and hyper dimensional datasets. Topic modeling is an active research field in machine learning and has been mainly used as an analytical tool to structure large textual corpora for data mining. Its ability to reduce high dimensionality to a small number of latent variables makes it suitable as a means for clustering or overcoming clustering difficulties in large biological and medical datasets.
  
  
  RESULTS
  In this study, three topic model-derived clustering methods, highest probable topic assignment, feature selection and feature extraction, are proposed and tested on the cluster analysis of three large datasets: Salmonella pulsed-field gel electrophoresis (PFGE) dataset, lung cancer dataset, and breast cancer dataset, which represent various types of large biological or medical datasets. All three various methods are shown to improve the efficacy/effectiveness of clustering results on the three datasets in comparison to traditional methods. A preferable cluster analysis method emerged for each of the three datasets on the basis of replicating known biological truths.
  
  
  CONCLUSIONS
  Topic modeling could be advantageously applied to the large datasets of biological or medical research. The three proposed topic model-derived clustering methods, highest probable topic assignment, feature selection and feature extraction, yield clustering improvements for the three different data types. Clusters more efficaciously represent truthful groupings and subgroupings in the data than traditional methods, suggesting that topic model-based methods could provide an analytic advancement in the analysis of large biological or medical datasets.
authors.forename: Weizhong
authors.initials: W
authors.lastname: Zhao
authors.forename: Wen
authors.initials: W
authors.lastname: Zou
authors.forename: James J
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000145:classification / Q000401:mortality; D016000:Cluster Analysis; D057225:Data Mining / Q000379:methods*; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification; D015233:Models, Statistical; D012475:Salmonella / Q000145:classification / Q000302:isolation & purification; D016019:Survival Analysis