title: Surveillance of invasive Neisseria meningitidis with a serogroup Y update, Sweden 2010 to 2012.
abstract: An increase of invasive meningococcal disease caused by Neisseria meningitidis serogroup Y has been noted in Sweden since 2005, and to a lower extent throughout Europe. The present study describes the epidemiology of invasive N. meningitidis isolates in Sweden in the period between 2010 and 2012, with a focus on serogroup Y. We also aimed to find an optimal molecular typing scheme for both surveillance and outbreak investigations. All invasive N. meningitidis isolates in Sweden during the study period (n=208) were genetically characterised. Serogroup Y predominated with 22/57, 31/61 and 44/90 of all invasive isolates (incidence 0.23, 0.33 and 0.46 per 100,000 population) in 2010, 2011 and 2012 respectively. In each of these years, 15/22, 22/31 and 19/44 of serogroup Y isolates were genetically clonal (Y: P1.5–2,10–1,36–2: F4–1: ST-23(cc23), ‘porB allele 3–36, fHbp allele 25 and penA allele 22). Our findings further support those of others that currently recommended FetA typing could be replaced by FHbp. Moreover, in line with a previous study that we conducted, the current results indicate that highly variable multilocus variable-number tandem repeat analysis (HV-MLVA) can be used as a first-hand rapid method for small outbreak investigations.
authors.affiliation: National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Clinical Microbiology/Molecular diagnostics R&D, orebro University Hospital, orebro, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Törös
authors.forename: S
authors.initials: S
authors.lastname: Thulin Hedberg
authors.forename: S
authors.initials: S
authors.lastname: Jacobsson
authors.forename: H
authors.initials: H
authors.lastname: Fredlund
authors.forename: P
authors.initials: P
authors.lastname: Olcén
authors.forename: P
authors.initials: P
authors.lastname: Mölling
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000235:genetics*; D008875:Middle Aged; D018598:Minisatellite Repeats; D058885:Multilocus Sequence Typing / Q000379:methods; D009345:Neisseria meningitidis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction / Q000379:methods; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D065288:Serogroup; D012703:Serotyping; D013548:Sweden / Q000453:epidemiology; D055815:Young Adult