title: Optical Coherence Tomography Imaging of Presumed Sarcoid Retinal and Optic Nerve Nodules.
abstract: OBJECTIVE
  To characterize nodular lesions of the retina and optic nerve with spectral-domain optical coherence tomography (SD-OCT) in patients with sarcoidosis.
  
  
  METHODS
  This is a retrospective series of 6 eyes from 5 patients with an established diagnosis of sarcoidosis, with clinically detected nodules of the optic nerve or retina. All lesions were imaged with fundus photography and SD-OCT on presentation, and followed with serial imaging after treatment with corticosteroids and/or immunomodulatory therapy.
  
  
  RESULTS
  Spectral OCT through the lesions revealed nodular hyperreflective processes obscuring the retinal layers or optic cup, with local structural changes, including subretinal and intraretinal fluid. After treatment with corticosteroids and/or immunosuppression in 4 followed patients, all lesions regressed with improvement in associated structural changes, but did not entirely disappear.
  
  
  CONCLUSIONS
  Spectral OCT can be useful in identifying lesion morphology and location, and in tracking the response to treatment in eyes with posterior-segment nodules, presumably secondary to sarcoidosis.
authors.affiliation: a Departments of Ophthalmology .
authors.forename: Naomi R
authors.initials: NR
authors.lastname: Goldberg
authors.affiliation: a Departments of Ophthalmology .|b Departments of Medicine .|c The Institute for Translational Epidemiology, The Icahn School of Medicine at Mount Sinai , New York , NY , and.|d The Center for Clinical Trials, The Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health , Baltimore , MD.
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Jabs
authors.affiliation: a Departments of Ophthalmology .
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Busingye
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D056747:Immunomodulation; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012164:Retinal Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D041623:Tomography, Optical Coherence
chemical_list: D005938:Glucocorticoids
keywords: Granuloma; OCT; nodule; optic nerve; retina; sarcoidosis