title: Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications.
abstract: Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin secretion and keeps pancreatic β-cells healthy and proliferating. Because of these beneficial effects, it has attracted a great deal of attention in the past decade, and an entirely new line of diabetic therapeutics has emerged based on the peptide. In addition to the therapeutic applications, GLP-1 analogs have demonstrated a potential in molecular imaging of pancreatic β-cells; this may be useful in early detection of the disease and evaluation of therapeutic interventions, including islet transplantation. In this Perspective, we focus on GLP-1 analogs for their studies on improvement of biological activities, enhancement of metabolic stability, investigation of receptor interaction, and visualization of the pancreatic islets.
authors.affiliation: Department of Chemistry, University of Texas at Dallas , Richardson, Texas 75080, United States.
authors.forename: Bikash
authors.initials: B
authors.lastname: Manandhar
authors.forename: Jung-Mo
authors.initials: JM
authors.lastname: Ahn
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D057054:Molecular Imaging
chemical_list: D052216:Glucagon-Like Peptide 1