title: Synthesis and biological evaluation of some novel furan derivatives.
abstract: The present work involved cyclization of Schiff bases to azetidine-2-one and thiazolidine 4-one derivatives. The schiff bases (IIIa-j) were obtained upon reaction between electrophillic carbon atom of furfuraldehyde and nucleophillic nitrogen atom of amines. Azetidine-2-one derivatives (IVa-j) were obtained by reaction between imines and monochloro acetyl chloride in the presence of triethyl amine and 1, 4 dioxan. On the other hand, preparations of thiazolidine-4-ones (Va-j) were preceded by nucleophilic attack of sulphur of thioglycolic acid on imine carbon followed by intramolecular cyclization in the presence of SnCl2. The structures of the compounds were confirmed by spectral and elemental analysis. The biological evaluation of the compounds like anti-microbial, antioxidant, analgesic, CNS depressant and anti-diabetic activity were determined. From the pharmacological investigation it was found that out of all the compounds IVa, IVb, IVe, IVf, IVh,Va, Vb, Ve, Vf, Vh had shown more potent activity.
authors.affiliation: IIMT College of Medical Sciences, O. Pocket, Ganganagar, Meerut, UP, India.
authors.forename: Sandip
authors.initials: S
authors.lastname: Sen
authors.affiliation: Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala, Tripura, India.
authors.forename: Biplab
authors.initials: B
authors.lastname: De
authors.affiliation: IIMT College of Medical Sciences, O. Pocket, Ganganagar, Meerut, UP, India.
authors.forename: T S
authors.initials: TS
authors.lastname: Easwari
mesh_terms: D000818:Animals; D005260:Female; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans