title: Temperature sensitivity of two-pore (K2P) potassium channels.
abstract: At normal body temperature, the two-pore potassium channels TREK-1 (K2P2.1/KCNK2), TREK-2 (K2P10.1/KCNK10), and TRAAK (K2P4.1/KCNK2) regulate cellular excitability by providing voltage-independent leak of potassium. Heat dramatically potentiates K2P channel activity and further affects excitation. This review focuses on the current understanding of the physiological role of heat-activated K2P current, and discusses the molecular mechanism of temperature gating in TREK-1, TREK-2, and TRAAK.
authors.affiliation: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Eve R
authors.initials: ER
authors.lastname: Schneider
authors.affiliation: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Evan O
authors.initials: EO
authors.lastname: Anderson
authors.affiliation: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA; Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Elena O
authors.initials: EO
authors.lastname: Gracheva
authors.affiliation: Department of Cellular & Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
authors.forename: Sviatoslav N
authors.initials: SN
authors.lastname: Bagriantsev
mesh_terms: D000818:Animals; D015640:Ion Channel Gating; D055595:Mechanical Phenomena; D015221:Potassium Channels / Q000737:chemistry / Q000378:metabolism*; D013697:Thermosensing
chemical_list: D015221:Potassium Channels
keywords: Ion channel; K(2P); Potassium channel; TRAAK; TREK-1; TREK-2; Thermosensitivity; Thermotransduction; Two-pore