title: TRPM7 involvement in cancer: a potential prognostic factor.
abstract: Calcium (Ca(2+)) and magnesium (Mg(2+)) are important metal elements that regulate a variety of cellular processes such as proliferation, migration, and apoptosis, in cancer cells. Among the ionic channels mediating intracellular entry, the transient receptor potential melastatin type 7 (TRPM7) channel is of particular interest, it being a non-selective, cationic channel mediating both Ca(2+) and Mg(2+) influx. TRPM7 is highly expressed in a number of human cancer tissues and cell lines. In this review, we summarise current knowledge on the physiological role of the dual function TRPM7 chanzyme, the potential application of TRPM7 as a diagnostic and prognostic marker of cancer progression with respect to clinical and pathological characteristics, and the molecular mechanisms implicated in cancerogenesis that specifically involve Ca(2+) and Mg(2+) influx through TRPM7 or kinase activity and interaction with cytoskeletal proteins.
authors.affiliation: University of Picardie Jules Verne, UFR Sciences, Laboratory of Cell and Molecular Physiology, EA 4667, SFR CAP-SANTE (FED 4231), Amiens, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Dhennin-Duthille
authors.affiliation: University of Picardie Jules Verne, UFR Sciences, Laboratory of Cell and Molecular Physiology, EA 4667, SFR CAP-SANTE (FED 4231), Amiens, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Gautier
authors.affiliation: University of Picardie Jules Verne, UFR Sciences, Laboratory of Cell and Molecular Physiology, EA 4667, SFR CAP-SANTE (FED 4231), Amiens, France.
authors.forename: Irina
authors.initials: I
authors.lastname: Korichneva
authors.affiliation: University of Picardie Jules Verne, UFR Sciences, Laboratory of Cell and Molecular Physiology, EA 4667, SFR CAP-SANTE (FED 4231), Amiens, France.
authors.forename: Halima
authors.initials: H
authors.lastname: Ouadid-Ahidouch
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D014408:Biomarkers, Tumor; D002118:Calcium / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D047108:Embryonic Development / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D017136:Ion Transport; D008274:Magnesium / Q000378:metabolism*; D008322:Mammals / Q000378:metabolism; D009363:Neoplasm Proteins / Q000737:chemistry / Q000502:physiology*; D009369:Neoplasms / Q000737:chemistry / Q000401:mortality; D011379:Prognosis; D011499:Protein Processing, Post-Translational / Q000502:physiology; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry / Q000502:physiology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology; D050053:TRPM Cation Channels / Q000737:chemistry / Q000502:physiology*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D050053:TRPM Cation Channels; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D008274:Magnesium; D002118:Calcium
keywords: TRPM7; channel activity; kinase function; migration; proliferation