title: Lipoxin A4 suppresses lipopolysaccharide-induced hela cell proliferation and migration via NF-κB pathway.
abstract: Uterine cervical carcinoma (UCC) is one of the most common malignant tumors in females, and UCC has a close relationship with chronic cervicitis. As the endogenous "braking signal," lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxin A4 (LXA4) on the proliferation, apoptosis, and migration in lipopolysaccharide (LPS)-stimulated Hela cells. We demonstrated that LXA4 could significantly suppress p53, cyclin D1 expression, and migration of LPS-stimulated Hela cells via nuclear factor-κB (NF-κB) pathway, and these effects could be blocked by Boc-2, the specific inhibitor of FPR2/ALX (the receptor of LXA4). We presented evidence for a novel role of LXA4 on the proliferation and migration in LPS-stimulated Hela cells, and FPR2/ALX was involved in the procedures. These results showed that LXA4 could be a possible candidate for UCC therapy, and blocking the activation of NF-κB would be an effective drug target.
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Nanchang University, No. 1 MinDe Road, Jiangxi Province, Nanchang City, 330006, China, haohua410@126.com.
authors.forename: Hua
authors.initials: H
authors.lastname: Hao
authors.forename: Fen
authors.initials: F
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Hao
authors.forename: Yuan-Qiao
authors.initials: YQ
authors.lastname: He
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhou
authors.forename: Hua
authors.initials: H
authors.lastname: Dai
authors.forename: Li-Qing
authors.initials: LQ
authors.lastname: Wu
authors.forename: Fan-Rong
authors.initials: FR
authors.lastname: Liu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002465:Cell Movement / Q000187:drug effects* / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006367:HeLa Cells; D006801:Humans; D008070:Lipopolysaccharides / Q000633:toxicity*; D044045:Lipoxins / Q000494:pharmacology*; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D044045:Lipoxins; D016328:NF-kappa B; C040527:lipoxin A4