title: Dynamic biointerfaces: from recognition to function.
abstract: The transformation of recognition signals into regulating macroscopic behaviors of biological entities (e.g., biomolecules and cells) is an extraordinarily challenging task in engineering interfacial properties of artificial materials. Recently, there has been extensive research for dynamic biointerfaces driven by biomimetic techniques. Weak interactions and chirality are two crucial routes that nature uses to achieve its functions, including protein folding, the DNA double helix, phospholipid membranes, photosystems, and shell and tooth growths. Learning from nature inspires us to design dynamic biointerfaces, which usually take advantage of highly selective weak interactions (e.g., synergetic chiral H-bonding interactions) to tailor their molecular assemblies on external stimuli. Biomolecules can induce the conformational transitions of dynamic biointerfaces, then drive a switching of surface characteristics (topographic structure, wettability, etc.), and eventually achieve macroscopic functions. The emerging progresses of dynamic biointerfaces are reviewed and its role from molecular recognitions to biological functions highlighted. Finally, a discussion is presented of the integration of dynamic biointerfaces with the basic biochemical processes, possibly solving the big challenges in life science.
authors.affiliation: State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, PR China.
authors.forename: Baisong
authors.initials: B
authors.lastname: Chang
authors.forename: Mingxi
authors.initials: M
authors.lastname: Zhang
authors.forename: Guangyan
authors.initials: G
authors.lastname: Qing
authors.forename: Taolei
authors.initials: T
authors.lastname: Sun
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000818:Animals; D032701:Biomimetics; D002384:Catalysis; D002448:Cell Adhesion; D006801:Humans; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D010743:Phospholipids; D011108:Polymers / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties; D017155:Wettability
chemical_list: D000180:Acrylic Resins; D010743:Phospholipids; D011108:Polymers; C052970:poly-N-isopropylacrylamide
keywords: H-bonding interactions; biointerfaces; biological functions; chirality; dynamic biointerfaces; molecular recognition