title: Use of protein cages as a template for confined synthesis of inorganic and organic nanoparticles.
abstract: Protein cages are hollow spherical proteins assembled from a defined number of subunits. Because they are extremely homogeneous in size and structure, their interior cavities can serve as ideal templates to encapsulate and synthesize well-defined nanoparticles. Here, we describe the exemplary synthesis of a hard and a soft material in two representative protein cages, i.e., magnetite nanoparticles in ferritin and a poly(2-aminoethyl)methacrylate inside a viral capsid derived from the bacteriophage P22.
authors.affiliation: Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.
authors.forename: Masaki
authors.initials: M
authors.lastname: Uchida
authors.forename: Shefah
authors.initials: S
authors.lastname: Qazi
authors.forename: Ethan
authors.initials: E
authors.lastname: Edwards
authors.forename: Trevor
authors.initials: T
authors.lastname: Douglas
mesh_terms: D017100:Bacteriophage P22; D002213:Capsid / Q000737:chemistry; D005021:Ethylamines / Q000737:chemistry; D005293:Ferritins / Q000737:chemistry; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D005021:Ethylamines; D058185:Magnetite Nanoparticles; D008689:Methacrylates; D011506:Proteins; C514459:aminoethyl methacrylate; D005293:Ferritins