title: Human Brucella canis Infection and Subsequent Laboratory Exposures Associated with a Puppy, New York City, 2012.
abstract: Human Brucella canis infection incidence is unknown. Most identified cases are associated with pet dogs. Laboratory-acquired infections can occur following contact with Brucella spp. We identified a paediatric B. canis case, the source and other exposed persons. A 3-year-old New York City child with fever and dyspnoea was hospitalized for 48 h for bronchiolitis. After her admission, blood culture grew B. canis, she was prescribed anti-microbials and recovered. B. canis was also isolated from blood of the child's pet dog; these isolates were genetically similar. The dog originated from an Iowa breeding facility which was quarantined after identification of the dog's infection. Additionally, 31 laboratory workers were exposed and subsequently monitored for symptoms; 15 completed post-exposure prophylaxis. To our knowledge, this is the first report strongly suggesting B. canis zoonotic transmission to a child in the United States, and highlights the need for coordinated control policies to minimize human illness.
authors.affiliation: New York City Department of Health and Mental Hygiene, New York City, NY, USA.|Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Office of Science and Public Health Practice, Atlanta, GA, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Dentinger
authors.affiliation: Downstate Medical Center, State University of New York, Brooklyn, NY, USA.
authors.forename: K
authors.initials: K
authors.lastname: Jacob
authors.affiliation: New York City Department of Health and Mental Hygiene, New York City, NY, USA.
authors.forename: L V
authors.initials: LV
authors.lastname: Lee
authors.affiliation: Downstate Medical Center, State University of New York, Brooklyn, NY, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Mendez
authors.affiliation: Downstate Medical Center, State University of New York, Brooklyn, NY, USA.
authors.forename: K
authors.initials: K
authors.lastname: Chotikanatis
authors.affiliation: Cornell University, New York State College of Veterinary Medicine, Ithaca, NY, USA.
authors.forename: P L
authors.initials: PL
authors.lastname: McDonough
authors.affiliation: New York State Department of Agriculture and Markets, Albany, NY, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Chico
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Disease, Atlanta, GA, USA.
authors.forename: B K
authors.initials: BK
authors.lastname: De
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Disease, Atlanta, GA, USA.
authors.forename: R V
authors.initials: RV
authors.lastname: Tiller
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Disease, Atlanta, GA, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Traxler
authors.affiliation: Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Office of Science and Public Health Practice, Atlanta, GA, USA.|Pennsylvania Department of Health, Bureau of Epidemiology, Harrisburg, PA, USA.
authors.forename: E R
authors.initials: ER
authors.lastname: Campagnolo
authors.affiliation: Iowa Department of Agriculture and Land Stewardship, Des Moines, IA, USA.
authors.forename: D
authors.initials: D
authors.lastname: Schmitt
authors.affiliation: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Disease, Atlanta, GA, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Guerra
authors.affiliation: New York City Department of Health and Mental Hygiene, New York City, NY, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Slavinski
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D041002:Brucella canis / Q000302:isolation & purification*; D002006:Brucellosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D002675:Child, Preschool; D003132:Commerce; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology* / Q000635:transmission; D004285:Dogs; D005260:Female; D006801:Humans; D007484:Iowa / Q000453:epidemiology; D009519:New York City / Q000453:epidemiology; D010414:Pennsylvania / Q000453:epidemiology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D015047:Zoonoses
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
keywords: Brucella canis; Brucella infection; brucellosis; canine brucellosis; laboratory exposure; personal protection; pet breeders; pet dogs; veterinary treatment; zoonosis