title: In vivo analysis of burns in a mouse model using spectroscopic optical coherence tomography.
abstract: Spectroscopic analysis of biological tissues can provide insight into changes in structure and function due to disease or injury. Depth-resolved spectroscopic measurements can be implemented for tissue imaging using optical coherence tomography (OCT). Here, spectroscopic OCT is applied to in vivo measurement of burn injury in a mouse model. Data processing and analysis methods are compared for their accuracy. Overall accuracy in classifying burned tissue was found to be as high as 91%, producing an area under the curve of a receiver operating characteristic curve of 0.97. The origins of the spectral changes are identified by correlation with histopathology.
authors.forename: Jason R
authors.initials: JR
authors.lastname: Maher
authors.forename: Volker
authors.initials: V
authors.lastname: Jaedicke
authors.forename: Manuel
authors.initials: M
authors.lastname: Medina
authors.forename: Howard
authors.initials: H
authors.lastname: Levinson
authors.forename: Maria Angelica
authors.initials: MA
authors.lastname: Selim
authors.forename: William J
authors.initials: WJ
authors.lastname: Brown
authors.forename: Adam
authors.initials: A
authors.lastname: Wax
mesh_terms: D000818:Animals; D002056:Burns / Q000473:pathology*; D004195:Disease Models, Animal; D051379:Mice; D012867:Skin / Q000473:pathology; D041623:Tomography, Optical Coherence