title: TfOH-catalyzed synthesis of 3-aryl isoindolinones via a tandem reaction.
abstract: A convenient metal-free method for the synthesis of 3-aryl isoindolinones via TfOH catalyzed aromatic C-H functionalization of electron-rich arenes with 2-formylbenzonitriles is developed. This process provided a new efficient strategy for the synthesis of isoindolinone derivatives in good to high yields and regioselectivities by forming two bonds.
authors.affiliation: Department of Pharmaceutical Engineering, Wuhan University of Technology, Wuhan, 430070, China. fanglinzhang0210@gmail.com zhenghua.whut@126.com.
authors.forename: Jiaxing
authors.initials: J
authors.lastname: Hu
authors.forename: Hua-Li
authors.initials: HL
authors.lastname: Qin
authors.forename: Wengang
authors.initials: W
authors.lastname: Xu
authors.forename: Junli
authors.initials: J
authors.lastname: Li
authors.forename: Fanglin
authors.initials: F
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Zheng
mesh_terms: D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D008698:Mesylates; D009570:Nitriles; C057812:indoline; C014356:benzonitrile; C012077:trifluoromethanesulfonic acid