title: Comparison of quantitative and semiquantitative dynamic contrast-enhanced MRI with respect to their correlation to delayed gadolinium-enhanced MRI of the cartilage in patients with early rheumatoid arthritis.
abstract: OBJECTIVE
  The objective of this study was to investigate the correlation between semiquantitative and quantitative dynamic contrast-enhanced (DCE) parameters with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of the cartilage (dGEMRIC).
  
  
  METHODS
  Fifteen patients with early rheumatoid arthritis (RA) from the ArthroMark cohort were investigated at a 3-T MRI scanner. The metacarpophalangeal (MCP) joint of the index finger was examined with DCE-MRI and dGEMRIC. Semiquantitative and quantitative DCE perfusion parameters were calculated. The RA MRI score of the second MCP joint and the joint space width were measured.
  
  
  RESULTS
  Significant correlations were noted between both semiquantitative and quantitative DCE parameters and the RA MRI score of the second MCP joint. There was a significant negative correlation between DCE parameters and dGEMRIC. No association between joint space width and DCE parameters was observed.
  
  
  CONCLUSIONS
  Semiquantitative and quantitative analyses of perfusion are applicable to show that cartilage damage correlates with the inflammation activity despite the absence of joint space narrowing.
authors.affiliation: From the Departments of *Diagnostic and Interventional Radiology, and †Rheumatology, University Dusseldorf, Medical Faculty, Dusseldorf, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Müller-Lutz
authors.forename: Christoph
authors.initials: C
authors.lastname: Schleich
authors.forename: Philipp
authors.initials: P
authors.lastname: Sewerin
authors.forename: Janina
authors.initials: J
authors.lastname: Gross
authors.forename: Gael
authors.initials: G
authors.lastname: Pentang
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Wittsack
authors.forename: Gerald
authors.initials: G
authors.lastname: Antoch
authors.forename: Matthias
authors.initials: M
authors.lastname: Schneider
authors.forename: Benedikt
authors.initials: B
authors.lastname: Ostendorf
authors.forename: Falk
authors.initials: F
authors.lastname: Miese
mesh_terms: D000465:Algorithms; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D002356:Cartilage / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics; D042241:Early Diagnosis; D005260:Female; D019786:Gadolinium DTPA / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008662:Metacarpophalangeal Joint / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D015588:Observer Variation; D010007:Osteochondritis / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA