title: Light-mediated antibacterial activity of Lippia origanoides H.B.K. in vitro.
abstract: An ethanol extract and different partition fractions obtained from Lippia origanoides H.B.K. were assayed for light-mediated activity against strains of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Identical assays were conducted with and without exposure to UV-A (400-315 nm) light to test for light enhanced activity. The ethanol extract and dichloromethane fraction showed light-mediated activity against the S. aureus strain, but not against the E. coli strain. The dichloromethane fraction was more active than the ethanol extract. Naringenin did not display light-mediated activity against the tested bacteria, indicating that the light-mediated antimicrobial activity of the dichloromethane fraction is not due to its major component. The results represent the first report of light-mediated antimicrobial activity of Lippia origanoides and show that its phytochemicals could be used as light-mediated antimicrobial agents.
authors.affiliation: Laboratory of Research in Microbiology, Department of Parasitology and Microbiology, Federal University of Piauí, Teresina (PI), Brazil.
authors.forename: Humberto M
authors.initials: HM
authors.lastname: Barreto
authors.forename: Bruno R C
authors.initials: BR
authors.lastname: Coelho
authors.forename: Suellen M P
authors.initials: SM
authors.lastname: Menezes-Silva
authors.forename: José P
authors.initials: JP
authors.lastname: Siqueira-Júnior
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
authors.forename: Izabel Cristina S
authors.initials: IC
authors.lastname: Lemos
authors.forename: Taciana O
authors.initials: TO
authors.lastname: Sousa
authors.forename: Romézio A C
authors.initials: RA
authors.lastname: Silva
authors.forename: Maria das Graças F
authors.initials: Md
authors.lastname: Medeiros
authors.forename: Antonia M G L
authors.initials: AM
authors.lastname: Citó
authors.forename: José A D
authors.initials: JA
authors.lastname: Lopes
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects / Q000528:radiation effects; D044950:Flavanones / Q000737:chemistry; D032411:Lippia / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry; D017319:Photosensitizing Agents / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D044950:Flavanones; D017319:Photosensitizing Agents; D010936:Plant Extracts; D008752:Methylene Chloride; C005273:naringenin