title: Adenocarcinoma of the ampullary glands of the ductus deferens in a Sprague-Dawley rat.
abstract: Spontaneously occurring proliferative lesions of the male accessory sex glands are infrequent in various strains of rats. In rodents, the ampullary glands are embedded in the prostate. Although 2 spontaneous cases of atypical hyperplastic lesions at the ampullary gland were previously described in Wistar rats, adenocarcinoma and/or adenoma in this gland have not been reported. This study describes adenocarcinomas in the bilateral ampullary glands in a 52-week-old intact male Sprague-Dawley rat housed as part of a control group in a toxicological experiment. At necropsy, the body weight (644.4 g) and the weight of the prostate with ampullary gland (2.75 g) were similar to others of the same control group, and it had a normal gross appearance. Histopathologically, both ampullary glands revealed microinvasive adenocarcinoma without vascular invasion. The morphological characteristics of the neoplasm varied in different regions of the gland. Other parts of the male accessory sex glands did not show proliferative lesions.
authors.affiliation: Department of Toxicology, Laboratory Animal Sciences and Veterinary Anatomy, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Motohashi
authors.affiliation: Department of Toxicology, Laboratory Animal Sciences and Veterinary Anatomy, Azabu University School of Veterinary Medicine, Kanagawa, Japan wakui@azabu-u.ac.jp.
authors.forename: Shin
authors.initials: S
authors.lastname: Wakui
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Toxicology, Laboratory Animal Sciences and Veterinary Anatomy, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
authors.forename: Ayaka
authors.initials: A
authors.lastname: Yoshida
authors.affiliation: 1st Laboratory, Drug Safety Testing Center, Saitama, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Mutou
authors.affiliation: Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ikegami
authors.affiliation: Department of Toxicology, Laboratory Animal Sciences and Veterinary Anatomy, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Asari
authors.affiliation: Department of Toxicology, Laboratory Animal Sciences and Veterinary Anatomy, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
authors.forename: Tomo
authors.initials: T
authors.lastname: Inomata
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D005834:Genital Neoplasms, Male / Q000473:pathology / Q000662:veterinary*; D005837:Genitalia, Male / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014649:Vas Deferens / Q000473:pathology*
keywords: Sprague-Dawley rat; adenocarcinoma; ampullary gland; male accessory sex glands