title: Occupation and head and neck cancer in women-Results of the ICARE study.
abstract: BACKGROUND
  Few occupational studies have addressed head and neck cancer, and these studies have been predominantly conducted in men. Accordingly, our objective was to investigate the association between head and neck cancer and occupation in women.
  
  
  METHODS
  ICARE, a French population-based case-control study, included 296 squamous cell carcinomas of the head and neck in women and 775 controls. Lifelong occupational history was collected. Odds ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking and education level, were estimated for occupations and industries.
  
  
  RESULTS
  An elevated OR was observed for working proprietors working for 10 years or more (OR = 3.83, 95% CI: 1.12-13.0) with a significant trend with duration of employment (P = 0.047). Elevated but non-significant ORs were observed for street vendors (OR = 3.76, 95% CI: 0.99-14.3, P for trend = 0.13), bakers (OR = 4.19, 95% CI: 0.63-27.9, P for trend = 0.06), and welders and flame cutters (OR = 2.18, 95% CI: 0.33-14.4, P for trend = 0.05).
  
  
  CONCLUSIONS
  This exploratory study suggests a role of occupational exposures in the development of HN cancer in women. Further investigations of exposures to specific agents are needed.
authors.affiliation: Epidemiology of Occupational and Social Determinants of Health Team, Inserm, CESP Centre for research in Epidemiology and Population Health, UMRS 1018, Villejuif, France; UMRS 1018, University of Versailles St-Quentin, Villejuif, France.
authors.forename: Matthieu
authors.initials: M
authors.lastname: Carton
authors.forename: Florence
authors.initials: F
authors.lastname: Guida
authors.forename: Sophie
authors.initials: S
authors.lastname: Paget-Bailly
authors.forename: Diane
authors.initials: D
authors.lastname: Cyr
authors.forename: Loredana
authors.initials: L
authors.lastname: Radoi
authors.forename: Marie
authors.initials: M
authors.lastname: Sanchez
authors.forename: Annie
authors.initials: A
authors.lastname: Schmaus
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cénée
authors.forename: Alexandra
authors.initials: A
authors.lastname: Papadopoulos
authors.forename: Gwenn
authors.initials: G
authors.lastname: Menvielle
authors.forename: Joëlle
authors.initials: J
authors.lastname: Févotte
authors.forename: Corinne
authors.initials: C
authors.lastname: Pilorget
authors.forename: Florence
authors.initials: F
authors.lastname: Molinié
authors.forename: Simona
authors.initials: S
authors.lastname: Bara
authors.forename: Isabelle
authors.initials: I
authors.lastname: Stücke
authors.forename: Danièle
authors.initials: D
authors.lastname: Luce
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology*; D006801:Humans; D009784:Occupational Diseases / Q000453:epidemiology*; D000077195:Squamous Cell Carcinoma of Head and Neck
keywords: cancer; larynx; occupational exposures; oral cavity; pharynx; women