title: An efficient synthetic route to 1,3-bis(arylethynyl)isobenzofuran using alkoxybenzocyclobutenone as a reactive platform.
abstract: An efficient synthetic method of 1,3-bis(arylethynyl)isobenzofurans is developed. Nucleophilic addition of alkynyllithium to benzocyclobutenone and subsequent oxidative ring cleavage of the four-membered ring gave a keto-aldehyde, which, in turn, accepted the second nucleophile to produce isobenzofurans after acid treatment.
authors.affiliation: Department of Chemistry, School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda, Hyogo 669-1337, Japan. thamura@kwansei.ac.jp.
authors.forename: Kenta
authors.initials: K
authors.lastname: Asahina
authors.forename: Suguru
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Nakayama
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hamura
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D003503:Cyclobutanes / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001572:Benzofurans; D003503:Cyclobutanes; D018020:Lithium Compounds