title: Association between ubiquitin carboxy-terminal hydrolase-L1 S18Y variant and risk of Parkinson's disease: the impact of ethnicity and onset age.
abstract: The Ubiquitin carboxy-terminal hydrolase-L1 (UCHL1) is a candidate risk gene for Parkinson' disease (PD), and a function SNP (rs5030732) in the coding region of this gene has been studied for the association with the disease extensively among worldwide populations, but the results were inconsistent and controversial. Here, to estimate the association between UCHL1 S18Y polymorphism and risk of PD in general population, we conducted a systematic meta-analysis by combining all available case-control subjects in Asian, European, and American populations, with a total of 7742 PD cases and 8850 healthy controls, and the pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for UCHL1 S18Y polymorphism and PD were calculated using the Mantel-Haenszel method with a fixed- or random-effects model. Subgroup analysis was also performed in different onset age-matched groups. Among high-quality studies, UCHL1 S18Y polymorphism was moderately associated with the risk of PD (allele contrasts, OR = 1.063, 95% CI 1.008-1.122; p = 0.024; regressive genetic model, OR = 1.078, 95% CI 1.005-1.157; p = 0.035). When stratifying for ethnicity, none association were observed in subgroups. Analysis of early-onset PD (EOPD) and late-onset PD (LOPD) revealed that the polymorphism was not associated with the risk of PD. In conclusion, our meta-analysis suggests that UCHL1 S18Y polymorphism is moderately associated with susceptibility to PD, and more studies are needed to confirm our conclusion.
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Anhui, Hefei, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Ci-Jiang
authors.initials: CJ
authors.lastname: Yao
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Zhu
authors.forename: Dao-Jun
authors.initials: DJ
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Lu
authors.forename: Ji-Yu
authors.initials: JY
authors.lastname: Cao
mesh_terms: D017668:Age of Onset; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D043222:Ubiquitin Thiolesterase / Q000235:genetics*; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase