title: Cyclin C surprises in tumour suppression.
abstract: Despite the importance of cyclins and cyclin-dependent kinases (Cdks) in the control of cell division, the physiological role of many of these regulators remains unknown. Cyclin C and its associated kinases Cdk3, Cdk8 and Cdk19 are now shown to function as tumour suppressors in haematopoietic malignancies by inhibiting the Notch1 pathway.
authors.affiliation: Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
authors.forename: Marianna
authors.initials: M
authors.lastname: Trakala
authors.affiliation: Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain.
authors.forename: Marcos
authors.initials: M
authors.lastname: Malumbres
mesh_terms: D000818:Animals; D056745:Cyclin C / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D006801:Humans; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism*; D051881:Receptor, Notch1 / Q000378:metabolism*
chemical_list: D056745:Cyclin C; D051881:Receptor, Notch1; D018844:Cyclin-Dependent Kinases