title: A critical review of food-associated factors proposed in the etiology of feline hyperthyroidism.
abstract: Since the first description of feline hyperthyroidism (HT) in 1979, several studies have been undertaken to define the etiology of the disease. Epidemiologic studies, after investigating non-food- and food-associated factors, suggest a multifactorial etiology. However, in the absence of prospective cohort studies that can confirm a cause-and-effect relationship between HT and associated risk factors, no causative factor for HT has been identified to date. Feline HT resembles toxic nodular goiter in humans, with autonomously functioning upregulated iodide uptake systems. Contribution of the diet to HT development remains controversial. The purpose of this paper is to review critically the reported food-associated risk factors for HT.
authors.affiliation: Royal Canin Research & Development Center, Aimargues, France ingrid.van.hoek@royalcanin.com.
authors.forename: Ingrid
authors.initials: I
authors.lastname: van Hoek
authors.affiliation: Department of Nutrition, Genetics and Ethology, Faculty of Veterinary Medicine, Ghent University, Ghent, Belgium.
authors.forename: Myriam
authors.initials: M
authors.lastname: Hesta
authors.affiliation: Royal Canin Research & Development Center, Aimargues, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Biourge
mesh_terms: D000821:Animal Feed; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000209:etiology*; D002415:Cats; D019587:Dietary Supplements; D006044:Goiter, Nodular / Q000662:veterinary; D006980:Hyperthyroidism / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D007455:Iodine / Q000502:physiology; D009751:Nutritional Requirements; D012307:Risk Factors
chemical_list: D007455:Iodine