title: ADV36 adipogenic adenovirus in human liver disease.
abstract: Obesity and liver steatosis are usually described as related diseases. Obesity is regarded as exclusive consequence of an imbalance between food intake and physical exercise, modulated by endocrine and genetic factors. Non-alcoholic fatty liver disease (NAFLD), is a condition whose natural history is related to, but not completely explained by over-nutrition, obesity and insulin resistance. There is evidence that environmental infections, and notably adipogenic adenoviruses (ADV) infections in humans, are associated not only with obesity, which is sufficiently established, but also with allied conditions, such as fatty liver. In order to elucidate the role, if any, of previous ADV36 infection in humans, we investigated association of ADV36-ADV37 seropositivity with obesity and fatty liver in humans. Moreover, the possibility that lifestyle-nutritional intervention in patients with NAFLD and different ADV36 seropositive status, achieves different clinical outcomes on ultrasound bright liver imaging, insulin resistance and obesity was challenged. ADV36 seropositive patients have a more consistent decrease in insulin resistance, fatty liver severity and body weight in comparison with ADV36 seronegative patients, indicating a greater responsiveness to nutritional intervention. These effects were not dependent on a greater pre-interventional body weight and older age. These results imply that no obvious disadvantage - and, seemingly, that some benefit - is linked to ADV36 seropositivity, at least in NAFLD. ADV36 previous infection can boost weight loss and recovery of insulin sensitivity under interventional treatment.
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: Francesca M
authors.initials: FM
authors.lastname: Trovato
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Catalano
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Garozzo
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: G Fabio
authors.initials: GF
authors.lastname: Martines
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Pirri
authors.affiliation: Francesca M Trovato, Daniela Catalano, G Fabio Martines, Clara Pirri, Guglielmo M Trovato, Department of Medical and Pediatric Sciences, Internal Medicine, University of Catania, 95100 Catania, Italy.
authors.forename: Guglielmo M
authors.initials: GM
authors.lastname: Trovato
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D000260:Adenoviruses, Human / Q000472:pathogenicity*; D050156:Adipogenesis; D000818:Animals; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism / Q000473:pathology / Q000821:virology*; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy / Q000821:virology*; D012307:Risk Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers
keywords: Human adenovirus 36; Insulin resistance; Mediterranean diet; Non-alcoholic fatty liver disease; Obesity; Ultrasound