title: [Serious bleeding as a consequence of accumulation of dabigatran caused by renal failure].
abstract: A 77-year-old male was hospitalized due to haematuria and developed septicaemia. He received dabigatran due to chronic atrial fibrillation. Doses were reduced because of renal failure according to guidelines. The patient showed extensive changes in his entire coagulation system. Due to renal failure forced diuresis was not possible, and continuous dialysis was performed. Patients with renal failure should be monitored closely - if there are any sign of bleeding it is important to consider change of anticoagulant therapy as long as an antidote does not exist.
authors.affiliation: Anæstesiologisk-intensiv Afdeling I, Aarhus Universitetshospital, Brendstrupgårdsvej 100, 8200 Aarhus N. anneskjo@rm.dk.
authors.forename: Anne Mette
authors.initials: AM
authors.lastname: Skjødt-Jensen
authors.forename: Anne-Mette
authors.initials: AM
authors.lastname: Hvas
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy; D000069604:Dabigatran / Q000008:administration & dosage / Q000506:poisoning* / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000295:instrumentation; D051437:Renal Insufficiency / Q000150:complications
chemical_list: D000991:Antithrombins; D000069604:Dabigatran