title: Immunomodulatory activity of interferon-beta.
abstract: Multiple sclerosis (MS) is a complex disorder of the central nervous system that appears to be driven by a shift in immune functioning toward excess inflammation that results in demyelination and axonal loss. Beta interferons were the first class of disease-modifying therapies to be approved for patients with MS after treatment with this type I interferon improved the course of MS on both clinical and radiological measures in clinical trials. The mechanism of action of interferon-beta appears to be driven by influencing the immune system at many levels, including antigen-presenting cells, T cells, and B cells. One effect of these interactions is to shift cytokine networks in favor of an anti-inflammatory effect. The pleiotropic mechanism of action may be a critical factor in determining the efficacy of interferon-beta in MS. This review will focus on select immunological mechanisms that are influenced by this type I cytokine.
authors.affiliation: Departments of Microbiology/Immunology and Medicine, Geisel School of Medicine, Dartmouth College Hanover, New Hampshire.
authors.forename: Lloyd H
authors.initials: LH
authors.lastname: Kasper
authors.affiliation: Department of Neurology, University of Chicago Chicago, Illinois.
authors.forename: Anthony T
authors.initials: AT
authors.lastname: Reder