title: The interaction between sickle cell disease and HIV infection: a systematic review.
abstract: Human immunodeficiency virus (HIV) and sickle cell disease (SCD) are regarded as endemic in overlapping geographic areas; however, for most countries only scarce data on the interaction between HIV and SCD and disease burden exist. HIV prevalence in SCD patients varies between 0% and 11.5% in published studies. SCD has been suggested to reduce disease progression of HIV into AIDS. Various interactions of antiretroviral therapy with SCD exist. Both SCD and HIV act as common risk factors for stroke, avascular necrosis, severe splenic dysfunction, pulmonary arterial hypertension, and sepsis, which may result in synergistic increase in risk of developing these diseases. No treatment guidelines regarding SCD with HIV coinfection were identified. Available evidence is mainly based on small clinical studies, thus making strong recommendations difficult. An increased effort to elucidate the precise interactions is warranted to better understand both diseases and effect more adequate treatment approaches, especially in view of their geographical coprevalence.
authors.affiliation: Department of Medical Laboratory Sciences, School of Allied Health Sciences, College of Health Sciences, University of Ghana, Accra Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam KIT Biomedical Research, Department of Parasitology, Amsterdam, The Netherlands.
authors.forename: Ewurama D A
authors.initials: ED
authors.lastname: Owusu
authors.affiliation: Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam Centre de Recherches Médicales de Lambaréné, Albert Schweitzer Hôpital, Lambaréné, Gabon Institute of Tropical Medicine, University of Tübingen, Germany.
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Visser
authors.affiliation: Medical Library, Academic Medical Center, University of Amsterdam, The Netherlands.
authors.forename: Ingeborg M
authors.initials: IM
authors.lastname: Nagel
authors.affiliation: Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam KIT Biomedical Research, Department of Parasitology, Amsterdam, The Netherlands.
authors.forename: Petra F
authors.initials: PF
authors.lastname: Mens
authors.affiliation: Center of Tropical Medicine and Travel Medicine, Academic Medical Center, University of Amsterdam Centre de Recherches Médicales de Lambaréné, Albert Schweitzer Hôpital, Lambaréné, Gabon Institute of Tropical Medicine, University of Tübingen, Germany.
authors.forename: Martin P
authors.initials: MP
authors.lastname: Grobusch
mesh_terms: D000349:Africa / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000453:epidemiology; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D006976:Hypertension, Pulmonary; D010020:Osteonecrosis / Q000209:etiology; D015995:Prevalence; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology; D020521:Stroke / Q000209:etiology
keywords: HIV; disease interaction; sickle cell disease; sickle cell trait; systematic review