title: Eight new bibenzyl derivatives from Dendrobium candidum.
abstract: Eight bibenzyl derivatives, namely dendrocandins J-Q (1-8), were isolated from the stems of Dendrobium candidum. Their structures were elucidated by 1D and 2D NMR experiments and mass spectrometry. Compounds 1-8 were examined for antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging assay, and the IC50 values were 36.8, 70.2, 45.0, 60.5, 87.6, 50.4, 22.3, and 30.3 μM, respectively.
authors.affiliation: a Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100193 , China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Chun-Lan
authors.initials: CL
authors.lastname: Wang
authors.forename: Hai-Jun
authors.initials: HJ
authors.lastname: Zhao
authors.forename: Shun-Xing
authors.initials: SX
authors.lastname: Guo
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification*; D001713:Biphenyl Compounds / Q000494:pharmacology; D031667:Dendrobium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001632:Bibenzyls; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Dendrobium candidum; antioxidant activity; bibenzyl derivatives; dendrocandins J–Q