title: Urine reflection of changes in blood.
abstract: The most important of nature of biomarker is changes. Blood is under strict homeostatic control which means changes tend to be removed from blood. Urine is a partial filtrate of blood, reflects systemic physiology but with no homeostatic mechanism. However, changes induced directly into the blood can be more sensitively detected in urine than in blood itself. This indicates that urine may serve as a source for more sensitive detection of protein biomarkers than blood.
authors.affiliation: National Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, 5 Dong Dan San Tiao, Beijing, China, menglinli86@gmail.com.
authors.forename: Menglin
authors.initials: M
authors.lastname: Li
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives; D015415:Biomarkers / Q000097:blood* / Q000652:urine*; D001798:Blood Proteins / Q000652:urine*; D002853:Chromatography, Liquid; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D010875:Pipecolic Acids / Q000494:pharmacology; D020543:Proteome / Q000032:analysis / Q000187:drug effects; D040901:Proteomics / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013449:Sulfonamides; D053719:Tandem Mass Spectrometry
chemical_list: D000925:Anticoagulants; D015415:Biomarkers; D001798:Blood Proteins; D010875:Pipecolic Acids; D020543:Proteome; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban