title: Chronic reparative changes in medium-sized vessels in a case of primary cutaneous anaplastic large-cell lymphoma with angioinvasive features and cytotoxic phenotype: new histopathological findings in line with indolent clinical behavior.
abstract: Angioinvasion/angiodestruction has been reported in a small subset of primary cutaneous anaplastic large-cell lymphomas (PCALCL). Recently, PCALCL with angioinvasive features and cytotoxic phenotype has been characterized as a variant associated with good clinical outcomes despite worrisome histopathologic features. We report a case of PCALCL with angioinvasive features and cytotoxic phenotype associated with reparative changes on the wall of medium-sized vessels involved by the neoplasm, including intimal fibroblastic proliferation and luminal obliteration. This vascular pattern, although previously unreported in PCALCL, is in accordance with the indolent behavior observed in this entity and provides a further link with lymphomatoid papulosis type E.
authors.affiliation: *Department of Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil; †Instituto do Cancer do Estado de São Paulo (ICESP), São Paulo, Brazil; and ‡Faculdade de Medicina de Botucatu, Departamento de Patologia, ViriCan, UNESP-Universidade Estadual Paulista, Campus Botucatu, Sao Paulo, Brazil.
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Macarenco
authors.forename: Deilson Elgui
authors.initials: DE
authors.lastname: de Oliveira
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001808:Blood Vessels / Q000737:chemistry / Q000473:pathology*; D049109:Cell Proliferation; D005347:Fibroblasts / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010641:Phenotype; D012867:Skin / Q000098:blood supply*; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor