title: The isolation and synthesis of neodolastane diterpenoids.
abstract: The neodolastane diterpenoids comprise a group of 44 compounds including guanacastepenes, heptemerones, plicatilisins, radianspenes, 2,15-epoxy-5,13-dihydroxyneodolast-3-en-14-one and sphaerostanol. These fungal and marine natural products are characterized by a tricyclic neodolastane skeleton that consists of fused five-, seven- and six-membered rings. Their reported antibiotic activities against antibiotic-resistant bacteria together with strong antifungal and anticancer activities and their novel structures render these compounds interesting synthetic targets. The aim of this account is to summarise the progress in the isolation, characterisation and synthesis of these diterpenoids as well as to review their biogenetic origins and diverse biological activities since their discovery in 2000.
authors.affiliation: Laboratoire de Pharmacognosie de Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, U.M.R./C.N.R.S. 8638, 4, Avenue de l'Observatoire, 75006 Paris, France. dean.markovic@parisdescartes.fr.
authors.forename: Dean
authors.initials: D
authors.lastname: Marković
authors.forename: Maria
authors.initials: M
authors.lastname: Kolympadi
authors.forename: Brigitte
authors.initials: B
authors.lastname: Deguin
authors.forename: François-Hugues
authors.initials: FH
authors.lastname: Porée
authors.forename: Māris
authors.initials: M
authors.lastname: Turks
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001688:Biological Products; D004224:Diterpenes; C409194:guanacastepene