title: Effects of a pharmacist-led structured medication review in primary care on drug-related problems and hospital admission rates: a randomized controlled trial.
abstract: OBJECTIVE
  To determine whether a pharmacist-led medications review in primary care reduces the number of drugs and the number of drug-related problems.
  
  
  METHODS
  Prospective randomized controlled trial.
  
  
  METHODS
  Liljeholmen Primary Care Centre, Stockholm, Sweden.
  
  
  METHODS
  209 patients aged ≥ 65 years with five or more different medications. Intervention. Patients answered a questionnaire regarding medications. The pharmacist reviewed all medications (prescription, non-prescription, and herbal) regarding recommendations and renal impairment, giving advice to patients and GPs. Each patient met the pharmacist before seeing their GP. Control patients received their usual care.
  
  
  METHODS
  Drug-related problems and number of drugs. Secondary outcomes included health care utilization and self-rated health during 12 months of follow-up.
  
  
  RESULTS
  No significant difference was seen when comparing change in drug-related problems between the groups. However, a significant decrease in drug-related problems was observed in the intervention group (from 1.73 per patient at baseline to 1.31 at follow-up, p < 0.05). The change in number of drugs was more pronounced in the intervention group (p < 0.046). Intervention group patients were not admitted to hospital on fewer occasions or for fewer days, and there was no significant difference between the two groups regarding utilization of primary care during follow-up. Self-rated health remained unchanged in the intervention group, whereas a drop (p < 0.02) was reported in the control group. This resulted in a significant difference in change in self-rated health between the groups (p < 0.047).
  
  
  CONCLUSIONS
  The addition of a skilled pharmacist to the primary care team may contribute to reductions in numbers of drugs and maintenance of self-rated health in elderly patients with polypharmacy.
authors.affiliation: Department of Clinical Sciences in Malmö, Lund University , Malmö , Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Lenander
authors.forename: Birgitta
authors.initials: B
authors.lastname: Elfsson
authors.forename: Birgitta
authors.initials: B
authors.lastname: Danielsson
authors.forename: Patrik
authors.initials: P
authors.lastname: Midlöv
authors.forename: Jan
authors.initials: J
authors.lastname: Hasselström
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D011307:Drug Prescriptions; D017723:Drug Utilization Review; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010343:Patient Admission / Q000706:statistics & numerical data; D010593:Pharmaceutical Services / Q000458:organization & administration*; D010595:Pharmacists; D019338:Polypharmacy; D011320:Primary Health Care; D011446:Prospective Studies; D013548:Sweden
keywords: Drug-related problems; Sweden; elderly; general practice; medication review; pharmacist; primary care