title: Characterization of major histocompatibility complex class I allele polymorphisms in common marmosets.
abstract: Currently, little information is available for major histocompatibility complex (MHC)-I that conditions the T-cell response of marmosets. In this study, 471 clones of MHC-I cDNA sequences were isolated from 12 marmosets. Twenty full-length sequences of class I G (Caja-G) alleles were obtained from these marmosets, 15 of them were novel. Among these 20 Caja-G alleles, 10 were found in individual animals while the rests were in two to four marmosets, but none was common to all animals. Ten marmosets possessed one to three Caja-G alleles, and two marmosets carried five or six alleles, which suggested that the Caja-G locus was duplicated in marmoset's genome. The high polymorphisms of Caja-G sequences provided important information helpful for understanding the cellular immune response in virus-infected marmosets.
authors.affiliation: Department of Transfusion Medicine, Southern Medical University, Guangzhou, China.
authors.forename: T
authors.initials: T
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Yin
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Zhu
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Liu
authors.forename: J-P
authors.initials: JP
authors.lastname: Allain
authors.forename: C
authors.initials: C
authors.lastname: Li
mesh_terms: D000483:Alleles; D000818:Animals; D002144:Callithrix; D005260:Female; D056426:Genetic Loci; D016678:Genome; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D008297:Male
chemical_list: D015395:Histocompatibility Antigens Class I
keywords: Caja-G; common marmosets; major histocompatibility complex-I; polymorphism