title: Insect heat shock proteins during stress and diapause.
abstract: Insect heat shock proteins include ATP-independent small heat shock proteins and the larger ATP-dependent proteins, Hsp70, Hsp90, and Hsp60. In concert with cochaperones and accessory proteins, heat shock proteins mediate essential activities such as protein folding, localization, and degradation. Heat shock proteins are synthesized constitutively in insects and induced by stressors such as heat, cold, crowding, and anoxia. Synthesis depends on the physiological state of the insect, but the common function of heat shock proteins, often working in networks, is to maintain cell homeostasis through interaction with substrate proteins. Stress-induced expression of heat shock protein genes occurs in a background of protein synthesis inhibition, but in the course of diapause, a state of dormancy and increased stress tolerance, these genes undergo differential regulation without the general disruption of protein production. During diapause, when ATP concentrations are low, heat shock proteins may sequester rather than fold proteins.
authors.affiliation: Department of Biology, Dalhousie University, Halifax, NS, B3H 4R2, Canada; email: allisonm.king@me.com , tmacrae@dal.ca.
authors.forename: Allison M
authors.initials: AM
authors.lastname: King
authors.forename: Thomas H
authors.initials: TH
authors.lastname: MacRae
mesh_terms: D000818:Animals; D064666:Diapause, Insect; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism; D007313:Insecta / Q000235:genetics / Q000254:growth & development / Q000502:physiology*; D007814:Larva / Q000254:growth & development / Q000502:physiology; D010063:Ovum / Q000254:growth & development / Q000502:physiology; D011679:Pupa / Q000254:growth & development / Q000502:physiology; D013312:Stress, Physiological
chemical_list: D006360:Heat-Shock Proteins; D019476:Insect Proteins
keywords: cochaperones; dormancy; molecular chaperones; stress tolerance