title: Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow.
abstract: Herein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process.
authors.affiliation: Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology , Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
authors.forename: Hannes P L
authors.initials: HP
authors.lastname: Gemoets
authors.forename: Volker
authors.initials: V
authors.lastname: Hessel
authors.forename: Timothy
authors.initials: T
authors.lastname: Noël
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D007211:Indoles / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D000475:Alkenes; D007211:Indoles; D016877:Oxidants; D010165:Palladium; D010100:Oxygen