title: Serum soluble bone turnover biomarkers in psoriatic arthritis and psoriatic spondyloarthropathy.
abstract: Because psoriatic arthritis (PsA) is an inflammatory disease of joints, serum soluble biomarkers specific for chronic joint and bone inflammation may predict future disease severity and response to therapy, thereby informing stratified medicine approaches. The objectives of our systematic review were to determine whether serum soluble bone and cartilage turnover biomarkers are (1) associated with PsA or psoriatic spondyloarthropathy; and (2) associated with disease activity, disease severity, or clinical phenotype. Ten studies met eligibility criteria. Matrix metalloproteinase (MMP)-3, Dickkopf (DKK)-1, macrophage colony-stimulating factor (M-CSF), crosslinked telopeptide of collagen-1, and tumor necrosis factor-related apoptosis-inducing ligand were associated with PsA, with equivocal results for osteoprotegerin (OPG) and bone alkaline phosphatase (ALP). MMP-3, DKK-1, M-CSF, CPII:C2C (ratio of cartilage degradation vs byproduct formation), and possibly OPG were associated with PsA independently of psoriasis. C1-2C (a neoepitope released when type 2 cartilage is degraded by collagenases) was associated with both tender and swollen joint counts, and bone morphogenetic protein-4 with patient global assessment of disease, pain score, and the Bath Ankylosing Spondylitis Disease Activity Index. Bone ALP was associated with disease activity. M-CSF and receptor activator of nuclear factor-κB ligand were associated with several plain radiographic features. No studies have investigated biomarker associations specifically with axial PsA.
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath. jadondr@yahoo.com.
authors.forename: Deepak R
authors.initials: DR
authors.lastname: Jadon
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath.
authors.forename: Alison L
authors.initials: AL
authors.lastname: Nightingale
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath.
authors.forename: Neil J
authors.initials: NJ
authors.lastname: McHugh
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lindsay
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath.
authors.forename: Eleanor
authors.initials: E
authors.lastname: Korendowych
authors.affiliation: From the Royal National Hospital for Rheumatic Diseases, and the University of Bath, Bath, UK.D.R. Jadon, MRCP, Research Fellow, Rheumatology; E. Korendowych, FRCP, Consultant Rheumatologist; R. Sengupta, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases; A.L. Nightingale, PhD, Research Fellow; M.A. Lindsay, PhD, Professor, Pharmacy and Pharmacology, University of Bath; N.J. McHugh, FRCP, Consultant Rheumatologist, Royal National Hospital for Rheumatic Diseases, and the University of Bath.
authors.forename: Raj
authors.initials: R
authors.lastname: Sengupta
mesh_terms: D015535:Arthritis, Psoriatic / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016723:Bone Remodeling / Q000502:physiology*; D006801:Humans; D025242:Spondylarthropathies / Q000097:blood*
chemical_list: D015415:Biomarkers
keywords: ARTHRITIS; BIOLOGICAL MARKERS; DICKKOPF-1; MATRIX; METALLOPROTEINASE; PSORIATIC; PSORIATIC SPONDYLOARTHRITIS