title: Selenoproteins and cardiovascular stress.
abstract: Dietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others. In this review, we summarise the current understanding of the roles these selenoproteins play in protecting the cardiovascular system from different types of stress including ischaemia-reperfusion, homocysteine dysregulation, myocardial hypertrophy, doxirubicin toxicity, Keshan disease, and others.
authors.forename: Aaron H
authors.initials: AH
authors.lastname: Rose
authors.affiliation: Peter R. Hoffmann, University of Hawaii, John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, HI 96813, USA, Fax: +1 808 692 1968, E-mail: peterrh@hawaii.edu.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hoffmann
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000503:physiopathology; D002319:Cardiovascular System / Q000378:metabolism* / Q000503:physiopathology; D004032:Diet; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D051150:Methionine Sulfoxide Reductases / Q000378:metabolism; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012643:Selenium / Q000378:metabolism*; D051140:Selenoproteins / Q000378:metabolism*; D013312:Stress, Physiological; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D051140:Selenoproteins; D005979:Glutathione Peroxidase; D013880:Thioredoxin-Disulfide Reductase; D051150:Methionine Sulfoxide Reductases; D012643:Selenium
keywords: Cardiovascular; heart; oxidative stress; selenium; selenoproteins