title: Central venous oxygen saturation: a potential new marker for circulatory stress in haemodialysis patients?
abstract: OBJECTIVE
  Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required.
  
  
  METHODS
  Intra-dialytic central venous oxygen saturation (ScvO2) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients.
  
  
  RESULTS
  Pre-dialysis ScvO2 was 63.5 ± 13% and fell significantly to 56.4 ± 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO2 (r = -0.680, p = 0.015).
  
  
  CONCLUSIONS
  This initial study demonstrates ScvO2 sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.
authors.affiliation: Department of Renal Medicine, Royal Derby Hospital, Derby, UK.
authors.forename: Laura E A
authors.initials: LE
authors.lastname: Harrison
authors.forename: Nicholas M
authors.initials: NM
authors.lastname: Selby
authors.forename: Christopher W
authors.initials: CW
authors.lastname: McIntyre
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001775:Blood Circulation; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D010100:Oxygen / Q000097:blood*; D006435:Renal Dialysis; D013312:Stress, Physiological; D014680:Veins
chemical_list: D015415:Biomarkers; D010100:Oxygen