title: Leptin signaling.
abstract: Leptin is secreted by adipose tissue and regulates energy homeostasis, glucose and lipid metabolism, immune function, and other systems. The binding of leptin to its specific receptor activates various intracellular signaling pathways, including Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)/phosphatidylinositol 3 kinase (PI3K), SH2-containing protein tyrosine phosphatase 2 (SHP2)/mitogen-activated protein kinase (MAPK), and 5' adenosine monophosphate-activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC), in the central nervous system and peripheral tissues. Understanding of leptin signaling provides insights into its roles in health and disease.
authors.affiliation: Department of Internal Medicine, Soonchunhyang University College of Medicine 22, Daesagwan-gil (657 Hannam-dong), Yongsan-gu, Seoul Korea.
authors.forename: Hyeong-Kyu
authors.initials: HK
authors.lastname: Park
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania 12-104 Smilow Center for Translational Research, 3400 Civic Center Boulevard, Building 421, Philadelphia, Pennsylvania 19104 USA.
authors.forename: Rexford S
authors.initials: RS
authors.lastname: Ahima