title: Aortic dissection during antiangiogenic therapy with sunitinib. A case report.
abstract: BACKGROUND
  Sunitinib is an antiangiogenic drug that has been approved for treating metastatic renal cancer. Its action as a tyrosine kinase inhibitor of vascular endothelial growth factor receptors (VEGFRs) and other angiogenesis receptors may lead to adverse effects such as hypertension and heart failure. However, reports in the literature on an association between sunitinib therapy and acute aortic dissection are rare.
  
  
  METHODS
  We report the case of a 68-year-old man with metastatic renal carcinoma who developed acute aortic dissection during sunitinib therapy. He had no history of hypertension or any other risk factor for aortic dissection. After aortic dissection had been diagnosed, sunitinib was withdrawn and an aortic endoprosthesis was placed. Afterwards, the patient was treated clinically with antihypertensive drugs and new therapy for renal cancer consisting of temsirolimus, an inhibitor of the mammalian target of rapamycin (mTOR) pathway.
  
  
  CONCLUSIONS
  Hypertension is a common event when antiangiogenic drugs are used in oncology. However, knowledge of other severe cardiovascular events that may occur in these patients, such as acute aortic dissection, is important. Adequate control over arterial pressure and frequent monitoring of patients during the first days of antiangiogenic therapy is essential for early diagnosis of possible adverse events.
authors.affiliation: Hospital A. C. Camargo, São Paulo, Brazil.
authors.forename: Maria Nirvana da Cruz
authors.initials: MN
authors.lastname: Formiga
authors.affiliation: Department of Clinical Oncology, Hospital A. C. Camargo, São Paulo, Brazil.
authors.forename: Marcello Ferretti
authors.initials: MF
authors.lastname: Fanelli
mesh_terms: D000368:Aged; D000784:Aortic Dissection / Q000139:chemically induced* / Q000000981:diagnostic imaging; D020533:Angiogenesis Inhibitors / Q000009:adverse effects*; D001014:Aortic Aneurysm / Q000139:chemically induced* / Q000000981:diagnostic imaging; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000150:complications; D007211:Indoles / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D011758:Pyrroles / Q000009:adverse effects*; D011859:Radiography; D000077210:Sunitinib
chemical_list: D020533:Angiogenesis Inhibitors; D007211:Indoles; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; D000077210:Sunitinib