title: A Dose-Finding Method Based on Multiple Dosing in Two-Agent Combination Phase I Trials.
abstract: Here, we developed a new dose-finding method that partitions a cohort of patients based on the number of dose combinations within a prespecified acceptable toxicity range in two-agent combination Phase I trials. In the proposed method, patients in the same cohort are partitioned according to several dose combinations, although most of the existing methods allocate patients in the same cohort according to a single-dose combination. We compared the operating characteristics of the proposed and existing methods through simulation studies.
authors.affiliation: a Department of Management Science, Graduate School of Engineering , Tokyo University of Science , Tokyo , Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kakurai
authors.forename: Akihiro
authors.initials: A
authors.lastname: Hirakawa
authors.forename: Chikuma
authors.initials: C
authors.lastname: Hamada
mesh_terms: D000465:Algorithms; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D017321:Clinical Trials, Phase I as Topic / Q000379:methods* / Q000706:statistics & numerical data; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D004347:Drug Interactions; D006801:Humans; D016015:Logistic Models; D009716:Numerical Analysis, Computer-Assisted; D011336:Probability; D012107:Research Design / Q000706:statistics & numerical data; D016896:Treatment Outcome
keywords: Combination; Dose-finding studies; Multiple dosing; Phase I trials