title: Effect of intravitreal injection of dexamethasone implant on corneal endothelium in macular edema due to retinal vein occlusion.
abstract: OBJECTIVE
  To evaluate the effects of dexamethasone (DEX) implant (Ozurdex(®)) on corneal endothelium in patients with retinal vein occlusion complicated with macular edema.
  
  
  METHODS
  Patients (n = 31) received 1-3 intravitreal DEX implants in one eye. Measurements were intraocular pressure (IOP) at baseline and 1, 3, and 6 months after the first intravitreal injection and corneal specular microscopy and central corneal thickness (CCT) at baseline and 1 and 6 months. We analyzed endothelial cell density (ECD), coefficient of variation of cell size (CV), and percentage of hexagonality.
  
  
  RESULTS
  Mean follow-up period was 9.7 ± 3.3 months. Mean number of injections was 1.5 ± 0.8. Mean IOP values were 15.6 ± 2.6 mm Hg at baseline, 17.7 ± 3.6 mm Hg at one month, 16.4 ± 4.1 mm Hg at three months, and 16.0 ± 2.7 mm Hg at six months. There was a significant difference in mean IOPs at one month and six months (p = 0.008). There were no significant differences in mean ECD (p = 0.375), CV (p = 0.661), percentage of hexagonality (p = 0.287), and CCT (p = 0.331).
  
  
  CONCLUSIONS
  Although intravitreal injection of 0.7 mg DEX causes moderate elevation of IOP, it does not seem to have detrimental effects on corneal endothelium at six months.
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Nilufer
authors.initials: N
authors.lastname: Ilhan
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Mesut
authors.initials: M
authors.lastname: Coskun
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ilhan
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Esra
authors.initials: E
authors.lastname: Ayhan Tuzcu
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Mutlu Cihan
authors.initials: MC
authors.lastname: Daglıoglu
authors.affiliation: b Department of Ophthalmology , Antakya State Hospital , Hatay , Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Elbeyli
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Ugurcan
authors.initials: U
authors.lastname: Keskin
authors.affiliation: a Department of Ophthalmology , Medical Faculty of the Mustafa Kemal University , Hatay , Turkey and.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Oksuz
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004343:Drug Implants; D004728:Endothelium, Corneal / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D008269:Macular Edema / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D004343:Drug Implants; D003907:Dexamethasone
keywords: Anterior eye segment; corticosteroid; drug delivery systems