title: A method for reproduction of metastases in the liver.
abstract: A new method for reproduction of metastatic involvement of the liver in outbred albino rats is proposed. The use of the method rules out the effects of stress factors (surgical intervention, total anesthesia) on malignant tumor metastasizing, making it maximally similar to the natural process. The method allows visual evaluation of the time course of the primary tumor node growth. The metastatic involvement of the liver develops only by the most significant route, hematogenic. The method can be used for the development of experimental therapy for this condition.
authors.affiliation: Rostov Oncological Research Institute, Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Kit
authors.forename: E M
authors.initials: EM
authors.lastname: Frantsiyants
authors.forename: I V
authors.initials: IV
authors.lastname: Kaplieva
authors.forename: L K
authors.initials: LK
authors.lastname: Trepitaki
authors.forename: O F
authors.initials: OF
authors.lastname: Evstratova
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D015179:Colorectal Neoplasms / Q000473:pathology*; D004195:Disease Models, Animal; D006652:Histological Techniques; D008114:Liver Neoplasms, Experimental / Q000556:secondary*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D051381:Rats