title: [Distribution of 4-methyl-2,6-diisobornylphenol in rat tissues].
abstract: We have studied the distribution of the new compound 4-methyl-2,6-diisobornylphenol in rats after a single oral administration in a dose of 20 mg/kg. The pharmacokinetic parameters have been estimated by the noncompartmental method. It is established that the drug is nonuniformly distributed in the body and has a high affinity for liver and heart. A low penetration of 4-methyl-2,6-diisobornilphenol has been found in brain tissue. The accumulation of 4-methyl-2,6-diisobornilphenol in adipose tissues has not been found. It been showed that the drug is slowly eliminated from the body, especially from the heart tissues for which the mean retention time is MRT = 45 h.
authors.forename: V I
authors.initials: VI
authors.lastname: Smol'iakova
authors.forename: G A
authors.initials: GA
authors.lastname: Chernysheva
authors.forename: E A
authors.initials: EA
authors.lastname: Ianovskaia
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: A V
authors.initials: AV
authors.lastname: Kuchin
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Chukicheva
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: M B
authors.initials: MB
authors.lastname: Plotnikov
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D001892:Camphanes / Q000097:blood / Q000493:pharmacokinetics*; D003408:Cresols / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005343:Fibrinolytic Agents / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: C533990:4-methyl-2,6-diisobornylphenol; D001892:Camphanes; D003408:Cresols; D005343:Fibrinolytic Agents