title: BRAF has a kinase-independent role in MAPK signaling.
abstract: BRAF has a regulatory role in the MAPK pathway that is dependent on its interaction with MEK1.
mesh_terms: D006801:Humans; D048369:MAP Kinase Kinase 1 / Q000737:chemistry / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D009154:Mutation; D048493:Proto-Oncogene Proteins B-raf / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D048369:MAP Kinase Kinase 1; C482125:MAP2K1 protein, human