title: The association of mannose-binding lectin genetic polymorphisms with the risk of rheumatoid arthritis: a meta-analysis.
abstract: OBJECTIVE
  To better understand the risks of rheumatoid arthritis (RA) and certain subsets conferred by mannose-binding lectin (MBL2) polymorphisms in different races.
  
  
  METHODS
  Eighteen articles (4810 cases and 4585 controls) were identified from the latest literature search carried out in May 2014 using PubMed, Web of Science, Wanfang Database (Chinese) and Chinese National Knowledge Infrastructure. Three single nucleotide polymorphisms of codon 52, 54 and 57, exonic and extended genotypic variance in MBL2 were synthesized.
  
  
  RESULTS
  Codon 54 mutation of MBL2 was unlikely to be a risk factor for RA in overall population, but turned out to be deleterious in East Asian (four studies with 523 cases and 647 controls, pooled OR:1.63, 95% CI: 1.23-2.17). Codon 54 mutation increased the risk of seropositive and erosive RA by 44% and 162%, respectively (three studies with 281 cases and 358 controls, 95% CI: 1.01-2.05; 3 studies with 180 cases and 499 controls, 95% CI: 1.77-3.88). Furthermore, those risks were relatively stronger when restricted in East Asian (two studies with 147 cases and 244 controls, pooled OR: 1.85, 95% CI: 1.19-2.87; 2 studies with 170 cases and 291 controls, pooled OR: 2.78, 95% CI: 1.85-4.20). No remarkable associations were detected regarding codon 52, 57, exon 1 and extended genotype of MBL2.
  
  
  CONCLUSIONS
  Polymorphism of codon 54 in MBL2 may predispose to RA, especially seropositive or erosive RA, which East Asian appears to be more vulnerable.
authors.affiliation: a School of Public Health, Anhui Medical University , Hefei , Anhui , China and.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.affiliation: b Institute of Clinical Pharmacology, Anhui Medical University , Hefei , Anhui , China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
authors.affiliation: a School of Public Health, Anhui Medical University , Hefei , Anhui , China and.
authors.forename: Shu-Long
authors.initials: SL
authors.lastname: Li
authors.affiliation: a School of Public Health, Anhui Medical University , Hefei , Anhui , China and.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: a School of Public Health, Anhui Medical University , Hefei , Anhui , China and.
authors.forename: Qi-Xing
authors.initials: QX
authors.lastname: Zhu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003062:Codon; D005091:Exons; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D037601:Mannose-Binding Lectin / Q000172:deficiency / Q000235:genetics*; D008661:Metabolism, Inborn Errors / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D003062:Codon; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
keywords: Mannose-binding lectin; meta-analysis; polymorphism; rheumatoid arthritis; rheumatoid factor