title: Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment.
abstract: We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The genotypes of VEGF-2578C/A, -1154G/A, -634C/G, and -1498T/C were determined from blood extracted using a blood kit on a 384-well plate. The survival rate at 5 years was 55.47%. Multivariate analysis revealed that only tumor-node-metastasis (TNM) stage, metastasis, and the VEGF-2578 AA and -1154 AA genotypes were independent prognostic factors. Patients with TNM stage III-IV and metastasis showed a greatly increased risk of death from HCC, with hazard ratios (HRs) [95% confidence interval (CI)] of 3.64 (1.67-6.79) and 2.91 (1.30-6.27), respectively. Moreover, the VEGF-2578 AA and -1154 AA genotypes showed a significantly increased risk of death compared with the wild-type genotype (HR = 3.65, 95%CI = 1.35-11.13; HR = 7.13, 95%CI = 1.46-65.8). These results will be helpful for predicting clinical outcomes of HCC patients.
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: J
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Wang
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: T P
authors.initials: TP
authors.lastname: Jiang
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: T Z
authors.initials: TZ
authors.lastname: An
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: M
authors.initials: M
authors.lastname: Xu
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China.
authors.forename: X P
authors.initials: XP
authors.lastname: Wu
authors.affiliation: Department of Radiology, Affiliated Hospital of Guiyang Medical College, Guiyang, China wlz_wlz66@163.com.
authors.forename: S
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015331:Cohort Studies; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A