title: Antibiotic-resistant gram-negative bacterial infections in patients with cancer.
abstract: Patients with cancer are at high risk for infections caused by antibiotic resistant gram-negative bacteria. In this review, we summarize trends among the major pathogens and clinical syndromes associated with antibiotic resistant gram-negative bacterial infection in patients with malignancy, with special attention to carbapenem and expanded-spectrum β-lactam resistance in Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia--all major threats to our cancer patients. Optimal therapy for these antibiotic-resistant pathogens still remains to be determined.
authors.affiliation: Medical and Research Services, Louis Stokes Cleveland Veterans Affairs Medical Center Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio;
authors.forename: Federico
authors.initials: F
authors.lastname: Perez
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston.
authors.forename: Javier
authors.initials: J
authors.lastname: Adachi
authors.affiliation: Medical and Research Services, Louis Stokes Cleveland Veterans Affairs Medical Center Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio;
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects; D015780:Carbapenems / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009369:Neoplasms / Q000150:complications*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D020615:Stenotrophomonas maltophilia / Q000187:drug effects; D001618:beta-Lactamases / Q000627:therapeutic use
chemical_list: D015780:Carbapenems; D001618:beta-Lactamases
keywords: Acinetobacter baumannii; Pseudomonas aeruginosa; carbapenem-resistant Enterobacteriaceae; infections; neutropenia