title: The NOTCH pathway plays a tumor suppressive role in bladder cancer.
abstract: Inactivation of the NOTCH pathway drives bladder tumorigenesis.
mesh_terms: D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D051498:Receptor, Fibroblast Growth Factor, Type 3 / Q000235:genetics; D051881:Receptor, Notch1 / Q000235:genetics / Q000378:metabolism; D051883:Receptor, Notch2 / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D001749:Urinary Bladder Neoplasms / Q000235:genetics / Q000378:metabolism; D018631:ras Proteins / Q000235:genetics
chemical_list: C497761:NOTCH1 protein, human; C497764:NOTCH2 protein, human; D051881:Receptor, Notch1; D051883:Receptor, Notch2; C496365:FGFR3 protein, human; D051498:Receptor, Fibroblast Growth Factor, Type 3; D018631:ras Proteins