title: Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells.
abstract: The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm3, the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 μg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3-4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain-related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Yebin
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Hu
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Weijia
authors.initials: W
authors.lastname: Sun
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Duan
authors.affiliation: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Chen
keywords: glyceryl trinitrate; immune escape; nitric oxide signaling pathway; pancreatic carcinoma cells