title: Borderline Brenner tumor of the ovary: a case report with immunohistochemical and molecular study.
abstract: BACKGROUND
  Borderline Brenner tumor of the ovary is a rare entity characterized by papillary structures with a fibro-vascular core, covered by a transitional epithelium, and by the absence of stromal infiltration. It is associated, by definition, with a benign component of Brenner tumor.
  
  
  METHODS
  We report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses.
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. rosselladececio@libero.it.
authors.forename: Rossella
authors.initials: R
authors.lastname: De Cecio
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. monicantile@libero.it.
authors.forename: Monica
authors.initials: M
authors.lastname: Cantile
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. francesca.collina@virgilio.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Collina
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. lauradali@hotmail.com.
authors.forename: Laura
authors.initials: L
authors.lastname: Marra
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. c.santonastaso@istitutotumori.na.it.
authors.forename: Clemente
authors.initials: C
authors.lastname: Santonastaso
authors.affiliation: Department of Gynecologic Oncology, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. c.scaffa@istitutotumori.na.it.
authors.forename: Cono
authors.initials: C
authors.lastname: Scaffa
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. g.botti@istitutotumori.na.it.
authors.forename: Gerardo
authors.initials: G
authors.lastname: Botti
authors.affiliation: Pathology Unit, Istituto Nazionale Tumori Fondazione "G. Pascale", via Mariano Semmola, 80131, Napoli, Italy. sim.los@tiscali.it.
authors.forename: Nunzia Simona
authors.initials: NS
authors.lastname: Losito
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001948:Brenner Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D004252:DNA Mutational Analysis; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D011859:Radiography
chemical_list: D014408:Biomarkers, Tumor; C512478:EGFR protein, human; D066246:ErbB Receptors