title: A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China.
abstract: Migrating wild birds are considered natural reservoirs of influenza viruses and serve as a potential source of novel influenza strains in humans and livestock. During routine avian influenza surveillance conducted in eastern China, a novel H5N8 (SH-9) reassortant influenza virus was isolated from a mallard duck in China. blast analysis revealed that the HA, NA, PB1, PA, NP, and M segments of SH-9 were most closely related to the corresponding segments of A/duck/Jiangsu/k1203/2010 (H5N8). The SH-9 virus preferentially recognized avian-like influenza virus receptors and was highly pathogenic in mice. Our results suggest that wild birds could acquire the H5N8 virus from breeding ducks and spread the virus via migratory bird flyways.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, China; Research Center of Wildlife Disease, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute of Academy of Military Medical Sciences, Changchun, China.
authors.forename: Shengtao
authors.initials: S
authors.lastname: Fan
authors.forename: Lichen
authors.initials: L
authors.lastname: Zhou
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Gao
authors.forename: Enle
authors.initials: E
authors.lastname: Pei
authors.forename: Tianhou
authors.initials: T
authors.lastname: Wang
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Gao
authors.forename: Xianzhu
authors.initials: X
authors.lastname: Xia
mesh_terms: D000818:Animals; D002681:China; D004372:Ducks / Q000821:virology*; D005260:Female; D009980:Influenza A virus / Q000145:classification / Q000302:isolation & purification* / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000821:virology*; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D017422:Sequence Analysis, DNA; D016019:Survival Analysis; D014764:Viral Proteins / Q000235:genetics
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins
keywords: H5N8; highly pathogenic avian influenza virus; wild duck