title: Identifying the Association Between Alzheimer's Disease and Parkinson's Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network.
abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-scale genome-wide association studies (GWAS) have been conducted and reported a number of AD and PD variants. Until now, the underlying genetic mechanisms for all these newly identified PD variants as well as the association between AD and PD are still unclear exactly. We think that PD variants may contribute to AD and PD by influence on brain gene expression. Here, we conducted a systems analysis using (1) AD and PD variants (P < 5.00E-08) identified by the published GWAS; (2) four brain expression GWAS datasets using expression quantitative trait loci from the cerebellum and temporal cortex; (3) large-scale AD GWAS from the Alzheimer Disease Genetics Consortium (ADGC); (4) a protein-protein interaction network. Our results indicated that PD variants around the 17q21 were associated with gene expression and suggestive AD risk. We also identified significant interaction among AD and PD susceptibility genes. We believe that our findings may explain the underlying genetic mechanisms for newly identified PD variants in PD and AD, as well as the association between AD and PD, which may be very useful for future genetic studies for both diseases.
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.|Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China.
authors.forename: Guiyou
authors.initials: G
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
authors.forename: Xinjie
authors.initials: X
authors.lastname: Bao
authors.affiliation: College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
authors.forename: Yongshuai
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: College of Life Science, Northwest A&F University, Yangling, Shaanxi, China.
authors.forename: Mingzhi
authors.initials: M
authors.lastname: Liao
authors.affiliation: School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
authors.forename: Qinghua
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
authors.forename: Rennan
authors.initials: R
authors.lastname: Feng
authors.affiliation: Department of Statistics, Rice University, Houston, TX, USA.
authors.forename: Liangcai
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China.
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
authors.affiliation: Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: Zugen
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Oncology, The First Hospital of Harbin, Harbin, China.
authors.forename: Guangyu
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China. wangrz@126.com.
authors.forename: Renzhi
authors.initials: R
authors.lastname: Wang
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China. binzhao0759@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China. keshenli2012@163.com.
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D060066:Protein Interaction Maps / Q000235:genetics*; D012307:Risk Factors
keywords: Alzheimer’s disease; Gene expression; Genome-wide association studies; Parkinson’s disease; Protein-protein interaction network