title: A case of radiation-induced osteosarcoma treated effectively by boron neutron capture therapy.
abstract: We treated a 54-year-old Japanese female with a recurrent radiation-induced osteosarcoma arising from left occipital skull, by reactor-based boron neutron capture therapy (BNCT). Her tumor grew rapidly with subcutaneous and epidural extension. She eventually could not walk because of cerebellar ataxia. The tumor was inoperable and radioresistant. BNCT showed a marked initial therapeutic effect: the subcutaneous/epidural tumor reduced without radiation damage of the scalp except hair loss and the patient could walk again only 3 weeks after BNCT. BNCT seems to be a safe and very effective modality in the management of radiation-induced osteosarcomas that are not eligible for operation and other treatment modalities.
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan. neu130@poh.osaka-med.ac.jp.
authors.forename: Gen
authors.initials: G
authors.lastname: Futamura
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan. neu046@poh.osaka-med.ac.jp.
authors.forename: Shinji
authors.initials: S
authors.lastname: Kawabata
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan. shibatti_nimitz@yahoo.co.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Siba
authors.affiliation: Department of Neurosurgery, Osaka Medical College, Takatsuki, Japan. neu040@poh.osaka-med.ac.jp.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kuroiwa
authors.affiliation: Particle Radiation Oncology Research Center, Kyoto University Research Reactor Institute, Kumatori, Japan. msuzuki@rri.kyoto-u.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Particle Radiation Oncology Research Center, Kyoto University Research Reactor Institute, Kumatori, Japan. nkondo@rri.kyoto-u.ac.jp.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Particle Radiation Oncology Research Center, Kyoto University Research Reactor Institute, Kumatori, Japan. onokoji@rri.kyoto-u.ac.jp.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.affiliation: Division of Radiation Life Science, Kyoto University Research Reactor Institute, Kumatori, Japan. yosakura@rri.kyoto-u.ac.jp.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Division of Innovative Cancer Therapy, and Department of Surgical Neuro-Oncology The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. mntanaka-neu@umin.ac.jp.
authors.forename: Minoru
authors.initials: M
authors.lastname: Tanaka
authors.affiliation: Division of Innovative Cancer Therapy, and Department of Surgical Neuro-Oncology The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. toudou-nsu@umin.ac.jp.
authors.forename: Tomoki
authors.initials: T
authors.lastname: Todo
authors.affiliation: Cancer Center, Osaka Medical College, Takatsuki, Japan. neu070@poh.osaka-med.ac.jp.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Miyatake
mesh_terms: D001859:Bone Neoplasms / Q000209:etiology / Q000532:radiotherapy*; D016754:Boron Neutron Capture Therapy; D001932:Brain Neoplasms / Q000150:complications / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000532:radiotherapy*; D012516:Osteosarcoma / Q000209:etiology / Q000532:radiotherapy*; D011379:Prognosis; D011878:Radiotherapy / Q000009:adverse effects*