title: The effect of pulsed dye laser on high-risk basal cell carcinomas with response control by Mohs micrographic surgery.
abstract: Several reports have shown the effectiveness of pulsed dye laser (PDL) for the treatment of basal cell carcinoma (BCC). Most studies have focused on low-risk BCCs, but an important limitation has been the lack of histologic confirmation of the treatment results. The aim of this study was to assess the effectiveness of PDL in high-risk BCCs with complete histologic evaluation with Mohs micrographic surgery (MMS). Seven patients with high-risk BCCs located on the face were included. All tumors were treated with three sessions of PDL (595 nm) at 4-week intervals. The tumor and 4 mm of peripheral skin were treated with two stacked pulses with a 1-s delay, a fluence of 15 J/cm(2), a pulse duration of 2 ms, and a spot size of 7 mm. MMS was performed at least 1 month after the last PDL session including excisional tumor debulking prior to the first stage of MMS for standard histologic evaluation. Apparent complete clinical response was achieved in five of seven patients. MMS was finally performed in six patients, and clear margins were achieved after one stage of MMS. The histologic evaluation of the tumor debulking specimens showed complete clearance in four of six cases. One patient who did not undergo MMS showed a recurrence after 14 months. This is the first pilot study that demonstrates that PDL can be effective for the treatment of high-risk BCCs. Until further scientific evidence is available, treatment of high-risk BCCs should include histologic confirmation of clearance.
authors.affiliation: Department of Dermatology, Ramón y Cajal University Hospital, Madrid, Spain, letticiaac@gmail.com.
authors.forename: Leticia
authors.initials: L
authors.lastname: Alonso-Castro
authors.forename: Luis
authors.initials: L
authors.lastname: Ríos-Buceta
authors.forename: Pablo
authors.initials: P
authors.lastname: Boixeda
authors.forename: John
authors.initials: J
authors.lastname: Paoli
authors.forename: Carmen
authors.initials: C
authors.lastname: Moreno
authors.forename: Pedro
authors.initials: P
authors.lastname: Jaén
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000601:surgery*; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D054025:Lasers, Dye / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015580:Mohs Surgery; D010865:Pilot Projects; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome