title: Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities.
abstract: Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive against the promastigote stages of L. chagasi and L. braziliensis.
authors.affiliation: Programa de Pós-Graduação em Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso do Sul, 79080-190, Campo Grande, MS, Brazil.
authors.forename: Aline Alves dos Santos
authors.initials: AA
authors.lastname: Naujorks
authors.forename: Adriano Olímpio
authors.initials: AO
authors.lastname: da Silva
authors.forename: Rosangela da Silva
authors.initials: Rda S
authors.lastname: Lopes
authors.forename: Sérgio
authors.initials: S
authors.lastname: de Albuquerque
authors.forename: Adilson
authors.initials: A
authors.lastname: Beatriz
authors.forename: Maria Rita
authors.initials: MR
authors.lastname: Marques
authors.forename: Dênis Pires
authors.initials: DP
authors.lastname: de Lima
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones; D014344:Trypanocidal Agents