title: [Simultaneous treatment of HIV and tuberculosis is possible and necessary].
abstract: The proper timing of antiretroviral therapy (ART) to HIV-patients co-infected with tuberculosis has been debated. We review three studies on this matter. One study found a significant reduced mortality for patients with CD4+ T-cell counts (CD4+) ≤ 200 per mm3 who received ART early, whereas the other two studies found this difference for patients with CD4+ < 50 per mm3.The risk of immune reconstitution inflammatory syndrome was significantly increased for the patients receiving ART early, but this contributed only to a small fraction of deaths related to HIV after the initiation of ART.
authors.affiliation: Vestervang 9, 971, 8000 Aarhus C. sarah_-vdm@hotmail.com.
authors.forename: Sarah
authors.initials: S
authors.lastname: von der Maase
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Christian
authors.initials: C
authors.lastname: Wejse
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D060085:Coinfection; D061345:Early Medical Intervention; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy* / Q000401:mortality
chemical_list: D044966:Anti-Retroviral Agents