title: In vivo evidence of epiretinal membrane formation secondary to acute macular microhole after posterior vitreous detachment.
abstract: The authors present the case of an idiopathic epiretinal membrane (ERM) secondary to an acute self-repaired macular microhole documented by optical coherence tomography (OCT). A 65-year-old phakic woman presenting with acute onset of light flashes, myodesopsia, and central negative scotoma in the right eye was diagnosed with age-related posterior vitreous detachment. Spectral-domain OCT showed a tiny defect of the outer retina, consistent with the diagnosis of macular microhole, which spontaneously closed after 4 weeks. Six months later, the patient developed a contracting ERM, and her visual acuity significantly worsened. This case represents the first in vivo documentation of retinal pigment epithelium cell migration through a macular microhole, highlighting the importance of OCT in understanding idiopathic ERM pathogenesis.
authors.forename: Claudio
authors.initials: C
authors.lastname: Furino
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Cicinelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Boscia
authors.forename: Giovanni
authors.initials: G
authors.lastname: Alessio
mesh_terms: D000208:Acute Disease; D000368:Aged; D001485:Basement Membrane / Q000473:pathology; D019773:Epiretinal Membrane / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D012167:Retinal Perforations / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D020255:Vitreous Detachment / Q000150:complications* / Q000175:diagnosis