title: [The distribution of mexidol in the rat's brain and its subcellular fractions].
abstract: OBJECTIVE
  To study the penetration of mexidol through the blood-brain barrier into different brain compartments and cell mitochondria.
  
  
  METHODS
  The study was carried out on adult male Wistar rats using the drug mexidol ("Farmasoft" Russia). The penetration of mexidol into different compartments of the brain (the cortex, cerebellum, thalamus and medulla) and distribution between mitochondrial and cytoplasmic fractions of the cerebral cortex was studied. The concentration of mexidol in blood plasma and brain tissues was measured using HPLC.
  
  
  CONCLUSIONS
  Mexidol penetrated through the blood-brain barrier into brain compartments of rats with the maximal accumulation in the cortex. In the brain cortex cells, mexidol was identified in the cytoplasmic and mitochondrial fractions.
authors.forename: A V
authors.initials: AV
authors.lastname: Shchul'kin
authors.forename: E N
authors.initials: EN
authors.lastname: Iakusheva
authors.forename: I V
authors.initials: IV
authors.lastname: Chernykh
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010847:Picolines / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate