title: The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.
abstract: Radiation therapy is an important treatment modality for abdominal or pelvic cancer, but there is a common and serious complication such as radiation-induced enteritis. Probiotics is reported to have positive effects against radiation-induced enteropathy. In this study, morphological changes of bowel mucosa were analyzed in rats to presume the effect of probiotics on radiation-induced enteritis and its correlation with radiation dose. A total of 48 adult male Sprague-Dawley rats were randomly assigned to two groups and received a solution containing 1.0×10(8) colony-forming units of Lactiobacillus acidophilus or water once daily for 10 days. Each of two groups was divided into three subgroups and abdomino-pelvic area of each subgroup was irradiated with 10, 15, and 20 Gy, respectively on the seventh day of feeding the solutions. All rats were sacrificed 3 days after irradiation and the mucosal thickness and villus height of jejunum, ileum and colon were measured. The morphological parameters of the small intestine represented significant differences between two solution groups irradiated 10 or 15 Gy, except for villus height of jejunum in 15 Gy-subgroup (P=0.065). There was no significant morphometric difference between two groups irradiated with 20 Gy of radiation. Probiotics appear to be effective for the morphological shortening of small intestinal mucosa damaged by radiation less than or equal to 15 Gy.
authors.affiliation: Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Yongkan
authors.identifier: 0000-0003-0757-8211
authors.initials: Y
authors.lastname: Ki
authors.affiliation: Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Wontaek
authors.identifier: 0000-0001-8626-7344
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Radiation Oncology, Inje University College of Medicine, Busan, Korea.
authors.forename: Heunglae
authors.identifier: 0000-0002-9799-1538
authors.initials: H
authors.lastname: Cho
authors.affiliation: Department of Radiation Oncology, Inje University College of Medicine, Busan, Korea.
authors.forename: Kijung
authors.identifier: 0000-0002-5163-0040
authors.initials: K
authors.lastname: Ahn
authors.affiliation: Department of Radiation Oncology, Dong-A University School of Medicine, Busan, Korea.
authors.forename: Youngmin
authors.identifier: 0000-0003-0190-4960
authors.initials: Y
authors.lastname: Choi
authors.affiliation: Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Dongwon
authors.identifier: 0000-0002-5511-6401
authors.initials: D
authors.lastname: Kim
mesh_terms: D000818:Animals; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D004751:Enteritis / Q000473:pathology / Q000517:prevention & control; D007082:Ileum / Q000473:pathology; D007413:Intestinal Mucosa / Q000382:microbiology / Q000528:radiation effects*; D007421:Intestine, Small; D007583:Jejunum / Q000473:pathology; D007779:Lactobacillus acidophilus / Q000378:metabolism*; D008297:Male; D019936:Probiotics / Q000008:administration & dosage / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000517:prevention & control* / Q000628:therapy; D011835:Radiation Protection / Q000379:methods*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
keywords: Enteritis; Probiotics; Radiation Therapy; Rats