title: Dexrazoxane: a cardioprotectant for pediatric cancer patients receiving anthracyclines.
abstract: Anthracyclines are a fundamental part of many childhood cancer therapy regimens; however, the discovery of anthracycline-induced cardiotoxicity has raised concern and led to dose limitation. The cardiotoxicity of anthracyclines has resulted in an increased demand for cardioprotectants. Dexrazoxane is the only cardioprotectant that has proven efficacy in reducing cardiotoxic effects when given prior to the administration of anthracyclines. Currently, it is still considered an "off-label" use due to a paucity of data in the literature on dexrazoxane administration in children. Nevertheless, through evaluation of the available data, dexrazoxane is observed to be safe, tolerable, and efficacious in mitigating the cardiotoxic effects of anthracycline in children, without jeopardizing its antineoplastic activity or increasing the risk of developing secondary malignant neoplasms.
authors.affiliation: University of Pennsylvania, Philadelphia, PA, USA vjwu@bcm.edu.
authors.forename: Vivian
authors.initials: V
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D018943:Anthracyclines / Q000009:adverse effects* / Q000627:therapeutic use*; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D066126:Cardiotoxicity / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D064730:Dexrazoxane / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000188:drug therapy*; D020011:Protective Agents / Q000627:therapeutic use
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D020011:Protective Agents; D064730:Dexrazoxane
keywords: anthracyclines; cardioprotectants; dexrazoxane; pediatric cancers