title: Carrot juice fermented with Lactobacillus plantarum NCU116 ameliorates type 2 diabetes in rats.
abstract: The effect of carrot juice fermented with Lactobacillus plantarum NCU116 on high-fat and low-dose streptozotocin (STZ)-induced type 2 diabetes in rats was studied. Rats were randomly divided into five groups: non-diabetes mellitus (NDM), untreated diabetes mellitus (DM), DM plus L. plantarum NCU116 (NCU), DM plus fermented carrot juice with L. plantarum NCU116 (FCJ), and DM plus non-fermented carrot juice (NFCJ). Treatments of NCU and FCJ for 5 weeks were found to favorably regulate blood glucose, hormones, and lipid metabolism in the diabetic rats, accompanied by an increase in short-chain fatty acid (SCFA) in the colon. In addition, NCU and FCJ had restored the antioxidant capacity and morphology of the pancreas and kidney and upregulated mRNA of low-density lipoprotein (LDL) receptor, cholesterol 7α-hydroxylase (CYP7A1), glucose transporter-4 (GLUT-4), peroxisome proliferator-activated receptor-α (PPAR-α), and peroxisome proliferator-activated receptor-γ (PPAR-γ). These results have for the first time demonstrated that L. plantarum NCU116 and the fermented carrot juice had the potential ability to ameliorate type 2 diabetes in rats.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University , 235 Nanjing East Road, Nanchang, Jiangxi 330047, People's Republic of China.
authors.forename: Chuan
authors.initials: C
authors.lastname: Li
authors.forename: Qiao
authors.initials: Q
authors.lastname: Ding
authors.forename: Shao-Ping
authors.initials: SP
authors.lastname: Nie
authors.forename: Yan-Song
authors.initials: YS
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Xiong
authors.forename: Ming-Yong
authors.initials: MY
authors.lastname: Xie
mesh_terms: D000818:Animals; D001628:Beverages / Q000032:analysis / Q000382:microbiology*; D001786:Blood Glucose / Q000378:metabolism; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D018552:Daucus carota / Q000378:metabolism / Q000382:microbiology*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000378:metabolism; D005285:Fermentation; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006801:Humans; D048191:Lactiplantibacillus plantarum / Q000378:metabolism*; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D047493:PPAR alpha / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D008077:Lipoproteins, LDL; D047493:PPAR alpha; D002790:Cholesterol 7-alpha-Hydroxylase
keywords: Lactobacillus plantarum NCU116; antidiabetic effect; blood glucose; carrot juice; oxidative stress; type 2 diabetes