title: Genetic factors associated with slow progression of HIV among perinatally-infected Indian children.
abstract: OBJECTIVE
  To study the association between common AIDS restriction genes and slow disease progression among perinatally-infected children in India.
  
  
  METHODS
  ART-naïve children were identified and selected host factors including CCR5-∆32, SDF1-3'A, CCR5-59029G, HLA-B*27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits.
  
  
  RESULTS
  Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-∆32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B*27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G.
  
  
  CONCLUSIONS
  There is an association between host genetic factors and slow disease progression in this population.
authors.affiliation: Departments *Clinical Virology, #Hematology Research Unit, Microbiology and Department of Pediatrics, St. John's Medical College Hospital, Bangalore, India. Correspondence to: Dr Anita Shet, Department of Pediatrics, St. Johns Medical College Hospital, Bangalore 560 034, India. anitashet@stjohns.in.
authors.forename: Riya Pal
authors.initials: RP
authors.lastname: Chaudhuri
authors.forename: Ujjwal
authors.initials: U
authors.lastname: Neogi
authors.forename: Shwetha D
authors.initials: SD
authors.lastname: Rao
authors.forename: Anita
authors.initials: A
authors.lastname: Shet
mesh_terms: D000293:Adolescent; D054377:Chemokine CXCL12 / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000235:genetics* / Q000635:transmission; D015235:HLA-B Antigens / Q000235:genetics; D015796:HLA-B27 Antigen / Q000235:genetics; D006801:Humans; D007194:India / Q000453:epidemiology; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D019713:Receptors, CCR5 / Q000235:genetics
chemical_list: C584933:CCR5 protein, human; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; C103707:HLA-B57 antigen; D019713:Receptors, CCR5