title: A phenacrylate scaffold for tunable thiol activation and release.
abstract: A thiol-selective 2-methyl-3-phenacrylate scaffold with spatiotemporal control over delivery of a cargo is reported. The half-lives of decomposition could be tuned from 30 min to 1 day and the scaffold's utility in thiol-inducible fluorophore release in cell-free as well as within cells is demonstrated.
authors.affiliation: Indian Institute of Science Education and Research Pune, Dr. Homi Bhabha Road, Pashan Pune 411 008, Maharashtra, India. harinath@iiserpune.ac.in.
authors.forename: Rathinam K
authors.initials: RK
authors.lastname: Sankar
authors.forename: Rohan S
authors.initials: RS
authors.lastname: Kumbhare
authors.forename: Allimuthu T
authors.initials: AT
authors.lastname: Dharmaraja
authors.forename: Harinath
authors.initials: H
authors.lastname: Chakrapani
mesh_terms: D000179:Acrylates / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003373:Coumaric Acids / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000179:Acrylates; D003373:Coumaric Acids; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds