title: The effects of breastfeeding on serum asymmetric dimethylarginine levels and body composition in children.
abstract: BACKGROUND
  The purpose of this work was to investigate the association of serum asymmetric dimethylarginine (ADMA) and high-sensitivity C-reactive protein (hs-CRP) levels with duration of breastfeeding and body composition in children.
  
  
  METHODS
  The study group consisted of 88 patients with a median age of 12 months (42 boys, 46 girls), classified as never breastfed or fully breastfed. ADMA and hs-CRP were measured by immunoenzymatic enzyme-linked immunosorbent assay commercial kits. Body composition analysis was performed by bioelectrical impedance.
  
  
  RESULTS
  We found significantly higher serum ADMA levels but not serum hs-CRP levels in never breastfed compared with the fully breastfed group (p<0.05). Serum ADMA was inversely associated with high-density lipoprotein-cholesterol levels and breastfeeding duration (p<0.05). Positive correlation was found between ADMA and body fat mass (p<0.05).
  
  
  CONCLUSIONS
  In never breastfed children, increased ADMA is observed; however, further studies are needed to assess whether breastfeeding duration affects body fat and body composition at older ages.
authors.affiliation: Department of Pediatrics and Nephrology, Medical University of Białystok , Białystok, Poland .
authors.forename: Renata
authors.initials: R
authors.lastname: Roszkowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Taranta-Janusz
authors.forename: Edyta
authors.initials: E
authors.lastname: Tenderenda-Banasiuk
authors.forename: Anna
authors.initials: A
authors.lastname: Wasilewska
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D001942:Breast Feeding; D002097:C-Reactive Protein / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008297:Male
chemical_list: D015415:Biomarkers; C018524:N,N-dimethylarginine; D002097:C-Reactive Protein; D001120:Arginine