title: Quantification of Interictal Neuromagnetic Activity in Absence Epilepsy with Accumulated Source Imaging.
abstract: Aberrant brain activity in childhood absence epilepsy (CAE) during seizures has been well recognized as synchronous 3 Hz spike-and-wave discharges on electroencephalography. However, brain activity from low- to very high-frequency ranges in subjects with CAE between seizures (interictal) has rarely been studied. Using a high-sampling rate magnetoencephalography (MEG) system, we studied ten subjects with clinically diagnosed but untreated CAE in comparison with age- and gender-matched controls. MEG data were recorded from all subjects during the resting state. MEG sources were assessed with accumulated source imaging, a new method optimized for localizing and quantifying spontaneous brain activity. MEG data were analyzed in nine frequency bands: delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), beta (12-30 Hz), low-gamma (30-55 Hz), high-gamma (65-90 Hz), ripple (90-200 Hz), high-frequency oscillation (HFO, 200-1,000 Hz), and very high-frequency oscillation (VHFO, 1,000-2,000 Hz). MEG source imaging revealed that subjects with CAE had higher odds of interictal brain activity in 200-1,000 and 1,000-2,000 Hz in the parieto-occipito-temporal junction and the medial frontal cortices as compared with controls. The strength of the interictal brain activity in these regions was significantly elevated in the frequency bands of 90-200, 200-1,000 and 1,000-2,000 Hz for subjects with CAE as compared with controls. The results indicate that CAE has significantly aberrant brain activity between seizures that can be noninvasively detected. The measurements of high-frequency neuromagnetic oscillations may open a new window for investigating the cerebral mechanisms of interictal abnormalities in CAE.
authors.affiliation: MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Xiang
authors.affiliation: MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Jeffrey.Tenney@cchmc.org.|Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA. Jeffrey.Tenney@cchmc.org.
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Tenney
authors.affiliation: MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Abraham M
authors.initials: AM
authors.lastname: Korman
authors.affiliation: MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Leiken
authors.affiliation: MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.|Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Rose
authors.affiliation: Child & Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Elana
authors.initials: E
authors.lastname: Harris
authors.affiliation: Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Weihong
authors.initials: W
authors.lastname: Yuan
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.|Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
authors.forename: Paul S
authors.initials: PS
authors.lastname: Horn
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Holland
authors.affiliation: Departments of Neurology and Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Loring
authors.affiliation: Division of Neurology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45229, USA.
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Glauser
mesh_terms: D001921:Brain / Q000503:physiopathology*; D058256:Brain Waves / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D004832:Epilepsy, Absence / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male
keywords: Childhood absence epilepsy; High frequency oscillation; Magnetic source imaging; Magnetoencephalography; Seizure