title: [Pharmaceutical treatment of lactation deficiency lacks evidence].
abstract: In this review we have looked at the evidence for the pharmacological treatment of lactation deficiency. Five RCTs (n = 166) of metoclopramide found no effect on lactation and two RCTs (n = 26) of older date and lesser quality found significant effect. One RCT (n = 51) of syntocinon found no effect on lactation and two older RCTs (n = 60) of lesser quality found significant effect. Three RCTs (n = 105) found significant effect of domperidone on lactation. Education on breastfeeding is important to avoid the need for pharmacological treatment.
authors.affiliation: Gynækologisk-obstetrisk Afdeling, Nordsjællands Hospital, Dyrehavevej 29, 3400 Hillerød. paulbryde@gmail.com.
authors.forename: Paul Bryde
authors.initials: PB
authors.lastname: Axelsson
authors.forename: Flemming
authors.initials: F
authors.lastname: Bjerrum
authors.forename: Ellen Christine Leth
authors.initials: EC
authors.lastname: Løkkegaard
mesh_terms: D001942:Breast Feeding; D004294:Domperidone / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects* / Q000502:physiology; D007775:Lactation Disorders / Q000188:drug therapy*; D008787:Metoclopramide / Q000009:adverse effects / Q000627:therapeutic use; D010120:Oxytocics / Q000627:therapeutic use; D010121:Oxytocin / Q000627:therapeutic use; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D018492:Dopamine Antagonists; D010120:Oxytocics; D010121:Oxytocin; D004294:Domperidone; D008787:Metoclopramide