title: Association of ACE, FABP2 and GST genes polymorphism with essential hypertension risk among a North Indian population.
abstract: BACKGROUND
  Hypertension has a multi-factorial background based on genetic and environmental interactive factors. ACE, FABP2 and GST genes have been suggested to be involved in the development of hypertension. However, the results have been inconsistent.
  
  
  OBJECTIVE
  The present study was carried out to investigate the association of ACE (rs4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism with essential HTN cases and controls.
  
  
  METHODS
  This study includes 138 essential hypertension (HTN) patients and 116 age-, sex- and ethnicity-matched control subjects. GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphisms were evaluated by multiplex PCR, ACE (rs4646994) gene polymorphisms by PCR and FABP2 (rs1799883) gene polymorphisms by PCR-RFLP method.
  
  
  RESULTS
  Significant differences were obtained in the frequencies of ACE DD, II genotype (p = 0.006, 0.003), GSTT1 null, GSTM1 positive genotype (p = 0.048, 0.010) and FABP2 Ala54/Ala54 genotype (p = 0.049) between essential HTN cases and controls.
  
  
  CONCLUSIONS
  It is concluded that ACE (rs 4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism are associated with HTN. Further investigation with a larger sample size may be required to validate this study.
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Shania
authors.initials: S
authors.lastname: Abbas
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Syed Tasleem
authors.initials: ST
authors.lastname: Raza
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Anu
authors.initials: A
authors.lastname: Chandra
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Saliha
authors.initials: S
authors.lastname: Rizvi
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Faisal
authors.initials: F
authors.lastname: Ahmed
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Ale
authors.initials: A
authors.lastname: Eba
authors.affiliation: a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D000075222:Essential Hypertension; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007194:India; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D050556:Fatty Acid-Binding Proteins; D005982:Glutathione Transferase; D007703:Peptidyl-Dipeptidase A; C493404:FABP2 protein, human; C413545:glutathione S-transferase T1; C488034:ACE protein, human
keywords: Cardiovascular diseases; ethnicity; gene polymorphism; polymerase chain reaction