title: Association of COMT Val158Met polymorphism with wearing-off susceptibility in Parkinson's disease.
abstract: In previous study, we have found the catechol-O-methyltransferase (COMT) Val158Met polymorphism may be associated with the risk of Parkinson's disease (PD) in Asians, especially Japanese population. In this study, we further evaluated the associations of PD wearing-off susceptibility with COMT polymorphisms. We carried out a retrieval of studies and included the relevant studies which met the criteria. After the data were extracted, the Stata software 11.0 was used to analyse the genotype frequencies. A total of five studies were included. The pooled result indicated that genotype AA was significantly associated with the wearing-off risk of PD (AA vs. others: OR = 2.52, 95 % CI 1.21-5.26, P = 0.013; AA vs. GA: OR = 2.51, 95 % CI 1.18-5.34, P = 0.017; AA vs. GG: OR = 2.17, 95 % CI 1.09-4.33, P = 0.027). The results also showed allele A was correlated with PD wearing-off risk (A vs. G: OR = 1.95, 95 % CI 1.18-3.22, P = 0.009). In conclusion, this study suggested that Val158Met polymorphisms in COMT may increase the risk of wearing-off. Further studies with larger sample sizes are needed to confirm our results.
authors.affiliation: School of Forensic Medicine, Kunming Medical University, No. 1168 West Chunrong Road, Yuhua Avenue, Chenggong District, Kunming, 650500, Yunnan, People's Republic of China.
authors.forename: Jianxing
authors.initials: J
authors.lastname: Liu
authors.forename: Pan
authors.initials: P
authors.lastname: Chen
authors.forename: Meihua
authors.initials: M
authors.lastname: Guo
authors.forename: Lechun
authors.initials: L
authors.lastname: Lu
authors.forename: Lihua
authors.initials: L
authors.lastname: Li
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D016206:Databases, Bibliographic; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007564:Japan; D008297:Male; D008715:Methionine / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics* / Q000503:physiopathology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014633:Valine / Q000235:genetics
chemical_list: D008715:Methionine; D002394:Catechol O-Methyltransferase; D014633:Valine