title: LaF3:Ln mesoporous spheres: controllable synthesis, tunable luminescence and application for dual-modal chemo-/photo-thermal therapy.
abstract: In this report, uniform LaF(3):Ln mesoporous spheres have been synthesized by a facile and mild in situ ion-exchange method using yolk-like La(OH)3:Ln mesoporous spheres as templates, which were prepared through a self-produced bubble-template route. It was found that the structures of the final LaF(3):Ln can simply be tuned by adding a polyetherimide (PEI) reagent. LaF(3):Ln hollow mesoporous spheres (HMSs) and LaF(3):Ln flower-like mesoporous spheres (FMSs) were obtained when assisted by PEI and in the absence of PEI. The up-conversion (UC) luminescence results reveal that the doping of Nd(3+) ions in LaF(3):Ln can markedly influence the UC emissions of the products. It is interesting that an obvious thermal effect is achieved due to the energy back-transfer from Tm(3+) to Nd(3+) ions under 980 nm near-infrared (NIR) irradiation. The LaF(3):Yb/Er/Tm/Nd HMSs show good biocompatibility and sustained doxorubicin (DOX) release properties. In particular, upon 980 nm NIR irradiation, the photothermal effect arising from the Nd(3+) doping induces a faster DOX release from the drug release system. Moreover, UC luminescence images of LaF(3):Yb/Er/Tm/Nd HMSs uptaken by MCF-7 cells exhibit apparent green emission under 980 nm NIR irradiation. Such a multifunctional carrier combining UC luminescence and hyperthermia with the chemotherapeutic drugs should be of high potential for the simultaneous anti-cancer therapy and cell imaging.
authors.affiliation: Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China. yangpiaoping@hrbeu.edu.cn hefei1@hrbeu.edu.cn.
authors.forename: Ruichan
authors.initials: R
authors.lastname: Lv
authors.forename: Guixin
authors.initials: G
authors.lastname: Yang
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Yunlu
authors.initials: Y
authors.lastname: Dai
authors.forename: Shili
authors.initials: S
authors.lastname: Gai
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D003460:Crystallization / Q000379:methods; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004338:Drug Combinations; D005459:Fluorides / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods*; D061986:MCF-7 Cells; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D058608:Nanopores / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D004338:Drug Combinations; D053769:Nanocapsules; D017319:Photosensitizing Agents; C083668:lanthanum trifluoride; D007811:Lanthanum; D004317:Doxorubicin; D005459:Fluorides