title: Anionic deep cavitands enable the adhesion of unmodified proteins at a membrane bilayer.
abstract: An anionic self-folding deep cavitand is capable of immobilizing unmodified proteins and enzymes at a supported lipid bilayer interface, providing a simple, soft bioreactive surface that allows enzymatic function under mild conditions. The adhesion is based on complementary charge interactions, and the hosts are capable of binding enzymes such as trypsin at the bilayer interface: the catalytic activity is retained upon adhesion, allowing selective reactions to be performed at the membrane surface.
authors.affiliation: University of California - Riverside, Department of Chemistry, Riverside, CA 92521, USA. richard.hooley@ucr.edu.
authors.forename: Yoo-Jin
authors.initials: YJ
authors.lastname: Ghang
authors.forename: Lizeth
authors.initials: L
authors.lastname: Perez
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Morgan
authors.forename: Fang
authors.initials: F
authors.lastname: Si
authors.forename: Omar M
authors.initials: OM
authors.lastname: Hamdy
authors.forename: Consuelo N
authors.initials: CN
authors.lastname: Beecher
authors.forename: Cynthia K
authors.initials: CK
authors.lastname: Larive
authors.forename: Ryan R
authors.initials: RR
authors.lastname: Julian
authors.forename: Wenwan
authors.initials: W
authors.lastname: Zhong
authors.forename: Quan
authors.initials: Q
authors.lastname: Cheng
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hooley
mesh_terms: D000595:Amino Acid Sequence; D000838:Anions / Q000737:chemistry; D004988:Ethers, Cyclic / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008969:Molecular Sequence Data; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012118:Resorcinols / Q000737:chemistry*; D055672:Static Electricity
chemical_list: D000838:Anions; D004988:Ethers, Cyclic; D008051:Lipid Bilayers; D011506:Proteins; D012118:Resorcinols; C442939:cavitand