title: CMOS time-resolved, contact, and multispectral fluorescence imaging for DNA molecular diagnostics.
abstract: Instrumental limitations such as bulkiness and high cost prevent the fluorescence technique from becoming ubiquitous for point-of-care deoxyribonucleic acid (DNA) detection and other in-field molecular diagnostics applications. The complimentary metal-oxide-semiconductor (CMOS) technology, as benefited from process scaling, provides several advanced capabilities such as high integration density, high-resolution signal processing, and low power consumption, enabling sensitive, integrated, and low-cost fluorescence analytical platforms. In this paper, CMOS time-resolved, contact, and multispectral imaging are reviewed. Recently reported CMOS fluorescence analysis microsystem prototypes are surveyed to highlight the present state of the art.
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. nanguo-c@my.cityu.edu.hk.
authors.forename: Nan
authors.initials: N
authors.lastname: Guo
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. kwcheun44-c@my.cityu.edu.hk.
authors.forename: Kawai
authors.initials: K
authors.lastname: Cheung
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. htwong39-c@my.cityu.edu.hk.
authors.forename: Hiu Tong
authors.initials: HT
authors.lastname: Wong
authors.affiliation: Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. derekho@cityu.edu.hk.
authors.forename: Derek
authors.initials: D
authors.lastname: Ho
mesh_terms: D004247:DNA / Q000032:analysis / Q000235:genetics*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005820:Genetic Testing / Q000295:instrumentation*; D017404:In Situ Hybridization, Fluorescence / Q000295:instrumentation*; D025202:Molecular Diagnostic Techniques / Q000295:instrumentation*; D019095:Point-of-Care Systems; D012666:Semiconductors; D013050:Spectrometry, Fluorescence / Q000295:instrumentation*
chemical_list: D004247:DNA