title: Cheng et al. reply.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Heping
authors.initials: H
authors.lastname: Cheng
authors.affiliation: Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington 98109, USA.
authors.forename: Wang
authors.initials: W
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Xianhua
authors.initials: X
authors.lastname: Wang
authors.affiliation: Center for Translational Medicine, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennyslvania 19107, USA.
authors.forename: Shey-Shing
authors.initials: SS
authors.lastname: Sheu
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Dirksen
authors.affiliation: National Institute of Biological Sciences, Beijing, Beijing 102206, China.
authors.forename: Meng-Qiu
authors.initials: MQ
authors.lastname: Dong
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D008136:Longevity; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D013481:Superoxides