title: [False positive dexamethasone suppression test in a patient being treated with carbamazepine].
abstract: We present a case story of a patient suspected having Cushing's syndrome (CS), with spuriously elevated P-cortisol level diagnosed by overnight and two days dexamethasone suppression test (DST). The patient was being treated with carbamazepine, and after two weeks withdrawal from this drug, both two-day DST and urinary free cortisol showed normal results. There are many pitfalls in the process of diagnosing CS. Several conditions mimic the disease and others cause hypercortisolism. Liver and kidney failure as well as several drugs can influence the test results. It is important to bare this in mind during the diagnostic work-up of suspected CS.
authors.affiliation: Medicinsk Endokrinologisk Afdeling, Aarhus Universitetshospital, Nørrebrogade 44, 8000 Aarhus C. anebiversen@gmail.com.
authors.forename: Ane Bull
authors.initials: AB
authors.lastname: Iversen
authors.forename: Christian
authors.initials: C
authors.lastname: Trolle
authors.forename: Per Løgstrup
authors.initials: PL
authors.lastname: Poulsen
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology* / Q000627:therapeutic use; D002220:Carbamazepine / Q000494:pharmacology* / Q000627:therapeutic use; D003480:Cushing Syndrome / Q000175:diagnosis*; D003907:Dexamethasone / Q000494:pharmacology*; D004347:Drug Interactions; D005189:False Positive Reactions; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D014277:Trigeminal Neuralgia / Q000188:drug therapy
chemical_list: D018712:Analgesics, Non-Narcotic; D005938:Glucocorticoids; D002220:Carbamazepine; D003907:Dexamethasone