title: Diastereoselective synthesis of α-(aminomethyl)-γ-butyrolactones via a catalyst-free aminolactonization.
abstract: An auto-catalytic domino reaction, presumably involving an aza-Michael reaction, proton transfer, and lactonization, furnishing α-(aminomethyl)-γ-butyrolactones in near quantitative yields and excellent diastereoselectivity is described.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN, 47907-2084 USA. chandran@purdue.edu.
authors.forename: P Veeraraghavan
authors.initials: PV
authors.lastname: Ramachandran
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Nicponski
mesh_terms: D015107:4-Butyrolactone / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003903:Deuterium / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D012997:Solvents; D003903:Deuterium; D015107:4-Butyrolactone