title: Vincristine-induced blindness: a case report and review of literature.
abstract: BACKGROUND
  Neurotoxicity is a dose-limiting side-effect of vincristine therapy. Blindness is a rare central neurotoxicity of vincristine with few case reports.
  
  
  METHODS
  In the present article, we report a rare case of vincristine-induced blindness in a patient with diffuse large B cell lymphoma. Literature search identified eleven published cases of vincristine-induced blindness. We reviewed patient characteristics, chemotherapy used and type of blindness.
  
  
  CONCLUSIONS
  Vincristine-induced blindness is rare and unpredictable. Prompt recognition and discontinuation of vincristine may lead to recovery of vision.
authors.affiliation: Cancer Center and Blood Institute, St Joseph Regional Medical Center, Lewiston, ID, U.S.A.
authors.forename: Subodh
authors.initials: S
authors.lastname: Adhikari
authors.affiliation: Cancer Center and Blood Institute, St Joseph Regional Medical Center, Lewiston, ID, U.S.A.
authors.forename: Raj Man
authors.initials: RM
authors.lastname: Dongol
authors.affiliation: Cancer Center and Blood Institute, St Joseph Regional Medical Center, Lewiston, ID, U.S.A.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Hewett
authors.affiliation: Cancer Center and Blood Institute, St Joseph Regional Medical Center, Lewiston, ID, U.S.A. binay.shah@gmail.com.
authors.forename: Binay Kumar
authors.initials: BK
authors.lastname: Shah
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001766:Blindness / Q000139:chemically induced* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D011379:Prognosis; D000069283:Rituximab; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Diffuse large B-cell lymphoma; blindness; neurotoxicity; vincristine