title: A new [2H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.
abstract: A new reaction pathway for the synthesis of a [(2)H]-labelled trichloroacetimidate precursor for the preparation of glucuronides is described. Therewith, stable isotope-labelled drug glucuronides become accessible on a preparative scale, which can further be used as internal standards for quantitative analysis.
authors.affiliation: Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology and University of Tuebingen, Auerbachstrasse 112, 70376 Stuttgart, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Heinkele
authors.forename: Mirjam C K
authors.initials: MC
authors.lastname: Geditz
authors.forename: Boian
authors.initials: B
authors.lastname: Ganchev
authors.forename: Reinhold
authors.initials: R
authors.lastname: Kerb
authors.forename: Ute
authors.initials: U
authors.lastname: Hofmann
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Mürdter
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis*; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D062845:Chloroacetates / Q000138:chemical synthesis*; D003903:Deuterium / Q000737:chemistry*; D020719:Glucuronides / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D000081:Acetamides; D062845:Chloroacetates; D020719:Glucuronides; D019275:Radiopharmaceuticals; D003903:Deuterium; C009528:trichloroacetamide
keywords: 2,3,4-[2H3]-6-Methyl-2,3,4-tri-O-isobutyryl-1-O-trichloroacetimidoyl-α-d-glucopyranuronate; 2′,3′,4′-[2H3]-Clomiphene-4-O-1′β-glucuronide; 2′,3′,4′-[2H3]-Dihydroartemisinin-12α,1′β-glucuronide; glucuronidation; stable isotope-labelled internal standard