title: MnO2-modified persistent luminescence nanoparticles for detection and imaging of glutathione in living cells and in vivo.
abstract: Persistent luminescence nanoparticles (PLNPs) hold great promise for the detection and imaging of biomolecules. Herein, we have demonstrated a novel nanoprobe, based on the manganese dioxide (MnO2 )-modified PLNPs, that can detect and image glutathione in living cells and in vivo. The persistent luminescence of the PLNPs can be efficiently quenched by the MnO2 nanosheets. In the presence of glutathione (GSH), MnO2 was reduced to Mn(2+) and the luminescence of PLNPs can be restored. The persistent luminescence property can allow detection and imaging without external excitation and avoid the background noise originating from the in situ excitation. This strategy can offer a promising platform for detection and imaging of reactive species in living cells or in vivo.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014 (P. R. China), Fax: (+86) 531-8618-0017.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Diao
authors.forename: Yaoyao
authors.initials: Y
authors.lastname: Han
authors.forename: Wei
authors.initials: W
authors.lastname: Pan
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D000818:Animals; D002460:Cell Line; D005978:Glutathione / Q000032:analysis*; D049449:Luminescence; D049408:Luminescent Agents / Q000737:chemistry*; D008264:Macrophages / Q000166:cytology; D017895:Manganese Compounds / Q000737:chemistry*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D061848:Optical Imaging; D010087:Oxides / Q000737:chemistry*
chemical_list: D049408:Luminescent Agents; D017895:Manganese Compounds; D010087:Oxides; D005978:Glutathione; C016552:manganese dioxide
keywords: cell imaging; glutathione; manganese dioxide; nanoparticles; nanotechnology