title: Nitrimines as reagents for metal-free formal C(sp(2) )-C(sp(2) ) cross-coupling reactions.
abstract: Nitrimines are employed as powerful reagents for metal-free formal C(sp(2) )-C(sp(2) ) cross-coupling reactions. The new chemical process is tolerant of a wide array of nitrimine and heterocyclic coupling partners giving rise to the corresponding di- or trisubstituted alkenes, typically in high yield and with high stereoselectivity. This method is ideal for the metal-free construction of heterocycle-containing drug targets, such as phenprocoumon.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, OH 43210 (USA) http://mattson.group.chemistry.ohio-state.edu/
authors.forename: Veronica V
authors.initials: VV
authors.lastname: Angeles-Dunham
authors.forename: David M
authors.initials: DM
authors.lastname: Nickerson
authors.forename: Devin M
authors.initials: DM
authors.lastname: Ray
authors.forename: Anita E
authors.initials: AE
authors.lastname: Mattson
keywords: alkenes; cross-coupling; heterocycles; metal-free reactions; nitrimine reagents