title: Antioxidative effect of rice bran oil and medium chain fatty acid rich rice bran oil in arsenite induced oxidative stress in rats.
abstract: The present study was adopted to evaluate the antioxidant efficacy of medium chain fatty acid (caprylic, capric and lauric) rich rice bran oils in comparison to rice bran oil in terms of altered biochemical parameters of oxidative stress following sodium arsenite treatment in rats. Animals were divided into ten groups; five normal groups and five arsenite treated groups. Results showed that activities of antioxidant enzymes in liver, brain and erythrocyte membrane increased with the administration of rice bran oil and MCFA rich rice bran oils both in normal and arsenite treated cases. Lipid peroxidation increased with the administration of sodium arsenite, but again administration of rice bran oil and MCFA rich rice bran oils decreased the lipid peroxidation. Caprylic acid rich rice bran oil showed the best ameliorative effects.
authors.affiliation: School of Community Science and Technology Indian Institute of Engineering, Science and Technology.
authors.forename: Avery
authors.initials: A
authors.lastname: Sengupta
authors.forename: Mahua
authors.initials: M
authors.lastname: Ghosh
authors.forename: Dipak K
authors.initials: DK
authors.lastname: Bhattacharyya
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001149:Arsenates / Q000633:toxicity*; D001921:Brain / Q000201:enzymology; D002210:Caprylates / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003652:Decanoic Acids / Q000494:pharmacology*; D003864:Depression, Chemical; D004910:Erythrocyte Membrane / Q000201:enzymology; D005980:Glutathione Reductase / Q000378:metabolism; D007850:Lauric Acids / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000201:enzymology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D017208:Rats, Wistar; D000073879:Rice Bran Oil; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001149:Arsenates; D002210:Caprylates; D003652:Decanoic Acids; D007850:Lauric Acids; D010938:Plant Oils; C030358:lauric acid; C031071:decanoic acid; C009277:sodium arsenate; D002374:Catalase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D000073879:Rice Bran Oil; C031492:octanoic acid