title: Introduction of a New Diagnostic Method for Breast Cancer Based on Fine Needle Aspiration (FNA) Test Data and Combining Intelligent Systems.
abstract: BACKGROUND
  Accurate Diagnosis of Breast Cancer is of prime importance. Fine Needle Aspiration test or "FNA", which has been used for several years in Europe, is a simple, inexpensive, noninvasive and accurate technique for detecting breast cancer. Expending the suitable features of the Fine Needle Aspiration results is the most important diagnostic problem in early stages of breast cancer. In this study, we introduced a new algorithm that can detect breast cancer based on combining artificial intelligent system and Fine Needle Aspiration (FNA).
  
  
  METHODS
  We studied the Features of Wisconsin Data Base Cancer which contained about 569 FNA test samples (212 patient samples (malignant) and 357 healthy samples (benign)). In this research, we combined Artificial Intelligence Approaches, such as Evolutionary Algorithm (EA) with Genetic Algorithm (GA), and also used Exact Classifier Systems (here by Fuzzy C-Means (FCM)) to separate malignant from benign samples. Furthermore, we examined artificial Neural Networks (NN) to identify the model and structure. This research proposed a new algorithm for an accurate diagnosis of breast cancer.
  
  
  RESULTS
  According to Wisconsin Data Base Cancer (WDBC) data base, 62.75% of samples were benign, and 37.25% were malignant. After applying the proposed algorithm, we achieved high detection accuracy of about "96.579%" on 205 patients who were diagnosed as having breast cancer. It was found that the method had 93% sensitivity, 73% specialty, 65% positive predictive value, and 95% negative predictive value, respectively. If done by experts, Fine Needle Aspiration (FNA) can be a reliable replacement for open biopsy in palpable breast masses. Evaluation of FNA samples during aspiration can decrease insufficient samples. FNA can be the first line of diagnosis in women with breast masses, at least in deprived regions, and may increase health standards and clinical supervision of patients.
  
  
  CONCLUSIONS
  Such a smart, economical, non-invasive, rapid and accurate system can be introduced as a useful diagnostic system for comprehensive treatment of breast cancer. Another advantage of this method is the possibility of diagnosing breast abnormalities. If done by experts, FNA can be a reliable replacement for open biopsy in palpable breast masses. Evaluation of FNA samples during aspiration can decrease insufficient samples.
authors.affiliation: Dept. of Bioengineering, Faculty of Electrical and Computer, Hakim Sabzevari University, Sabzevar, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fiuzy
authors.affiliation: Dept. of Bioengineering, Faculty of Electrical and Computer, Hakim Sabzevari University, Sabzevar, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Haddadnia
authors.affiliation: Dept. of Biology, Faculty of Basic Sciences, Hakim Sabzevari University, Sabzevar, Iran.
authors.forename: Nasrin
authors.initials: N
authors.lastname: Mollania
authors.affiliation: Dept. of Clinical Sciences, Sabzevar University of Medical Sciences, Sabzevar, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Hashemian
authors.affiliation: Dept. of Clinical Sciences, Sabzevar University of Medical Sciences, Sabzevar, Iran.
authors.forename: Kazem
authors.initials: K
authors.lastname: Hassanpour
keywords: Artificial intelligent; Breast cancer; Fine needle aspiration