title: Applications of nanoparticle systems in gene delivery and gene therapy.
abstract: For successful gene therapy, expansion of appropriate gene delivery systems could be one of the factors of major significance. Gene therapy provides large opportunities for treating diseases, including genetic disorders, infections, and cancer. Polymeric carriers have relatively low cytotoxicity and immunogenicity. Polymeric gene carriers are a potential substitute to using viral vectors. Overall, polymeric carriers can contain large-sized DNA, be conjugated with suitable functionalities, and be administered frequently. However, polymeric gene carriers have some restrictions, such as low gene transfection efficiencies and a moderately short period of gene expression. This study explores the current status of development of polymeric gene carriers, and presents guidelines for the prospective use of the polymer-based gene delivery systems in gene therapy.
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Taiebeh
authors.initials: T
authors.lastname: Kafshdooz
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Kafshdooz
authors.affiliation: a Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.|b Department of Medical Nanotechnology , Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences , Tabriz , Iran.
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.affiliation: c School of Mechanical Engineering, Yeungnam University , Gyeongsan , South Korea.
authors.forename: Younes
authors.initials: Y
authors.lastname: Hanifehpour
authors.affiliation: c School of Mechanical Engineering, Yeungnam University , Gyeongsan , South Korea.
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Joo
mesh_terms: D004247:DNA / Q000737:chemistry / Q000235:genetics; D004337:Drug Carriers / Q000737:chemistry*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D004247:DNA
keywords: gene carriers; gene delivery; gene therapy; immunogenicity