title: Compounds from the Chinese black ant (Polyrhachis dives) and NMR behavior of the isomers with formamide group.
abstract: Two new dopamine derivatives divesamides A (1) and B (2), along with six known N-containing compounds were isolated from the Chinese black ant (Polyrhachis dives). Their structures were determined on the basis of spectroscopic methods. Compound 1 is a racemate, and chiral HPLC separation yielded a pair of antipodes. The absolute configuration of (+)-1 was assigned by a computational method. The double signals in the (1)H and (13)C NMR spectra of 2 that resulted from the presence of a formamide group were discussed. The T- and B-lymphocytes proliferation assay showed that 2 has moderate immunosuppressive activity toward T- and B-lymphocytes proliferation at a concentration of 20 μM.
authors.affiliation: a College of Pharmacy, Chengdu University of Traditional Chinese Medicine , Chengdu 610075 , China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Tang
authors.forename: Qi
authors.initials: Q
authors.lastname: Luo
authors.forename: Lei
authors.initials: L
authors.lastname: Di
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Zuo
authors.forename: Hou-Lin
authors.initials: HL
authors.lastname: Xia
authors.forename: Xiu-Jing
authors.initials: XJ
authors.lastname: Ma
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001000:Ants / Q000737:chemistry*; D001402:B-Lymphocytes / Q000187:drug effects; D002681:China; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005559:Formamides / Q000737:chemistry / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D005559:Formamides; D007166:Immunosuppressive Agents; C000596417:divesamide A; C000596418:divesamide B; C031066:formamide; D004298:Dopamine
keywords: N-containing compound; Polyrhachis dives; amide bond; black ant; immunosuppressive activity