title: The many faces of Pulmonary Langerhans Cell Histiocytosis.
abstract: Langerhans Cell Histiocytosis is a rare disease with variable presentation and prognosis in adults and in children. Histiocytosis of the ocular choroidal tissue has never been reported before in adults. We present two cases, one with choroidal involvement with asymptomatic nodulo-cystic changes in the lungs and another case with advanced single organ pulmonary involvement. We discuss the various treatment modalities and highlight the lack of adequate guidelines to treat adults. Most of the current guidelines are based on evidence derived from pediatric literature. We would also like to draw attention to the asymptomatic nature of the lung involvement and suggest that imaging of the lung be obtained in all cases of Langerhans Cell Histiocytosis.
authors.affiliation: University of Pittsburgh Medical Center East. biswasa2@upmc.edu.
authors.forename: A
authors.initials: A
authors.lastname: Biswas
authors.forename: M
authors.initials: M
authors.lastname: Donahoe
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015862:Choroid Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005451:Fluorescein Angiography; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012074:Remission Induction; D016540:Smoking Cessation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014747:Vinblastine / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D014747:Vinblastine