title: Recent advances in asymmetric organocatalysis mediated by bifunctional amine-thioureas bearing multiple hydrogen-bonding donors.
abstract: Organocatalysis has proven to be one of the most rapidly developing and competitive research areas in asymmetric catalysis since 2000, and has become a third branch besides biocatalysis and transition metal catalysis. In this feature article, recent progress from our research group on asymmetric organocatalysis, focusing on fine-tunable amine-thiourea catalysis, is described. Design of novel bifunctional amine-thiourea organocatalysts based upon the synergistic activation strategy via multiple hydrogen bonds and their applications in asymmetric C-C, C-N, and C-S bond-forming reactions under mild conditions are discussed in detail. The most attractive feature of the newly designed fine-tunable amine-thiourea catalysts is the incorporation of multiple hydrogen bonding donors and stereogenic centers.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China. cjwang@whu.edu.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang