title: Asymmetric direct vinylogous Michael additions of allyl alkyl ketones to maleimides through dienamine catalysis.
abstract: A direct catalytic asymmetric γ-regioselective vinylogous Michael addition of allyl alkyl ketones to maleimides has been developed through dienamine catalysis of a simple chiral 1,2-diphenylethanediamine, giving multifunctional products in excellent enantioselectivity and with high yields. The success of this catalytic strategy relies on the unique inducing effect of deconjugated β,γ-C═C bond, which facilitates the formation of the otherwise unfavored extended dienamine species.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu 610041, China.
authors.forename: Gu
authors.initials: G
authors.lastname: Zhan
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Xin
authors.initials: X
authors.lastname: Yuan
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen