title: Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata.
abstract: Aervalanata possesses various useful medicinal and pharmaceutical activities. Phytochemical investigation of the plant has now led to the isolation of a new 2α,3α,15,16,19-pentahydroxy pimar-8(14)-ene diterpenoid (1) together with 12 other known compounds identified as β-sitosterol (2), β-sitosterol-3-O-β-D-glucoside (3), canthin-6-one (4), 10-hydroxycanthin-6-one (aervine, 5), 10-methoxycanthin-6-one (methylaervine, 6), β-carboline-1-propionic acid (7), 1-O-β-D-glucopyranosyl-(2S,3R,8E)-2-[(2'R)-2-hydroxylpalmitoylamino]-8-octadecene-1,3-diol (8), 1-O-(β-D-glucopyranosyl)-(2S,3S,4R,8Z)-2-[(2'R)-2'-hydroxytetracosanoylamino]-8(Z)-octadene-1,3,4-triol (9), (2S,3S,4R,10E)-2-[(2'R)-2'-hydroxytetracosanoylamino]-10-octadecene-1,3,4-triol (10), 6'-O-(4″-hydroxy-trans-cinnamoyl)-kaempferol-3-O-β-D-glucopyranoside (tribuloside, 11), 3-cinnamoyltribuloside (12) and sulfonoquinovosyldiacylglyceride (13). Among these, six compounds (8-13) are reported for the first time from this plant. Cytotoxicity evaluation of the compounds against five cancer cell lines (CHO, HepG2, HeLa, A-431 and MCF-7) shows promising IC50 values for compounds 4, 6 and 12.
authors.affiliation: a Department of Chemistry , Indian Institute of Chemical Biology, Council of Scientific and Industrial Research (CSIR) , 4 Raja S. C. Mullick Road, Jadavpur, Kolkata 700 032 , India.
authors.forename: Yogesh P
authors.initials: YP
authors.lastname: Bharitkar
authors.forename: Abhijit
authors.initials: A
authors.lastname: Hazra
authors.forename: N S
authors.initials: NS
authors.lastname: Apoorva Poduri
authors.forename: Anirban
authors.initials: A
authors.lastname: Ash
authors.forename: Prakas R
authors.initials: PR
authors.lastname: Maulik
authors.forename: Nirup B
authors.initials: NB
authors.lastname: Mondal
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification; D027703:Amaranthaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure
chemical_list: C000597440:2alpha,3alpha,15,16,19-pentahydroxy pimar-8(14)-ene; D045784:Abietanes; D004224:Diterpenes
keywords: 2D NMR (HSQC, HMBC, COSY, NOESY); Aerva lanata; cytotoxicity; pimarane diterpenoid