title: A case of HIV-associated diffuse infiltrative lymphocytosis syndrome simulating primary Sjögren syndrome and BALT Lymphoma.
abstract: Diffuse infiltrative lymphocytic syndrome is a clinical identity that can be part of the spectrum of Human Immunodeficiency Virus infection. It is characterized by sicca symptoms, parotid and lachrymal enlargement and extra-articular manifestations. We report the case of a 60 years old woman with clinical sicca syndrome in association with leukopenia, positive anti-nuclear antibody (ANA) and polyclonal hypergammaglobulinemia. In the follow up the patient developed a mucosa-associated lymphoid tissue pulmonary neoplasm. Furthermore, the clinical surveys revealed human immunodeficiency virus (HIV) positive markers. In this particular case report, we must underline the clinical presentation of a sicca syndrome as a manifestation of the HIV infection, bearing in mind that, frequently, the differential diagnosis from other diseases, namely the Sjögren's syndrome, is a real challenge.
authors.forename: João
authors.initials: J
authors.lastname: Rovisco
authors.forename: Tânia
authors.initials: T
authors.lastname: Santiago
authors.forename: Luís
authors.initials: L
authors.lastname: Inês
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008218:Lymphocytosis / Q000175:diagnosis* / Q000209:etiology*; D008223:Lymphoma / Q000175:diagnosis*; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000175:diagnosis*; D013577:Syndrome