title: Brevisulcatic acids, marine ladder-frame polyethers from the red tide dinoflagellate Karenia brevisulcata in New Zealand.
abstract: The isolation and structural determination of new marine ladder-frame polyethers, brevisulcatic acids-1 (1) and -4 (2) are reported. Brevisulcatic acids were isolated from the dinoflagellate Karenia brevisulcata, which was identified as the causative species of a major red tide event in New Zealand in 1998. The ether ring composition and a β-hydroxy, γ-methylene valeric acid side chain of 1 and 2 are common, but 2 has a γ-lactone as the 5-membered A-ring while 1 is the seco acid analogue. Compound 2 has structural and bioactivity similarities to brevetoxin A.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Rina
authors.initials: R
authors.lastname: Suzuki
authors.forename: Raku
authors.initials: R
authors.lastname: Irie
authors.forename: Yanit
authors.initials: Y
authors.lastname: Harntaweesup
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tachibana
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Holland
authors.forename: D Tim
authors.initials: DT
authors.lastname: Harwood
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Veronica
authors.initials: V
authors.lastname: Beuzenberg
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Itoh
authors.forename: Steven
authors.initials: S
authors.lastname: Pascal
authors.forename: Patrick J B
authors.initials: PJ
authors.lastname: Edwards
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
mesh_terms: D004141:Dinoflagellida / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry; D057097:Harmful Algal Bloom; D008386:Marine Biology; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular; D035964:Oxocins / Q000737:chemistry* / Q000302:isolation & purification*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D000095702:Polyether Toxins
chemical_list: D004987:Ethers; D008387:Marine Toxins; D035964:Oxocins; C000593729:brevisulcatic acid; C076262:Brevetoxin A; D000095702:Polyether Toxins