title: Treatments for nail psoriasis: a systematic review by the GRAPPA Nail Psoriasis Work Group.
abstract: Nail involvement in psoriatic diseases causes significant physical and functional disabilities. Evaluating, measuring, and treating nail involvement is important in improving the health outcomes and quality of life among patients with psoriasis and psoriatic arthritis (PsA). We performed a systematic analysis of the literature on nail psoriasis to help inform an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California. aprilarmstrong@post.harvard.edu.
authors.forename: April W
authors.initials: AW
authors.lastname: Armstrong
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: William
authors.initials: W
authors.lastname: Tuong
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: Thorvardur J
authors.initials: TJ
authors.lastname: Love
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: Sueli
authors.initials: S
authors.lastname: Carneiro
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: Rachel
authors.initials: R
authors.lastname: Grynszpan
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: Steve S
authors.initials: SS
authors.lastname: Lee
authors.affiliation: From the Psoriasis Program, Department of Dermatology, Colorado Health Outcomes Program (COHO), University of Colorado Denver, Denver, Colorado; Department of Dermatology, University of California Davis, Davis, California, USA; Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital, Reykjavik, Iceland; Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil; Southern California Permanente Medical Group, Fontana, California; and University of California, San Diego, California, USA.A.W. Armstrong, MD, MPH, Vice Chair for Clinical Research, Associate Professor of Dermatology, Director, Clinical Trials and Outcomes Research, Director, Psoriasis Program, Department of Dermatology, COHO, University of Colorado Denver; W. Tuong, BA, Department of Dermatology, University of California Davis; T.J. Love, MD, PhD, Faculty of Medicine, University of Iceland, Department of Research, Landspitali University Hospital; S. Carneiro, MD, PhD; R. Grynszpan, MD, Sector of Dermatology and Department of Medical Clinic, University Hospital and School of Medicine, Federal University of Rio de Janeiro; S.S. Lee, DO, FACR, Southern California Permanente Medical Group; A. Kavanaugh, MD, University of California.
authors.forename: Arthur
authors.initials: A
authors.lastname: Kavanaugh
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D003131:Combined Modality Therapy; D019317:Evidence-Based Medicine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D053685:Laser Therapy / Q000379:methods; D008297:Male; D009260:Nail Diseases / Q000175:diagnosis* / Q000628:therapy*; D011701:PUVA Therapy / Q000379:methods; D017410:Practice Guidelines as Topic; D011565:Psoriasis / Q000175:diagnosis* / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents
keywords: EFFECTIVENESS; EFFICACY; NAIL PSORIASIS; PSORIASIS; THERAPY; TREATMENT