title: Spectrum of antibodies to reproductive hormones in threatened abortion.
abstract: The spectrum of antibodies to reproductive hormones and the diagnostic significance of their measurements in threatened abortion during trimester I were studied. Enhanced production of antibodies to hormones was detected by ELISA in patients with threatened abortion (N=44) in comparison with women with normal gestation (N=30). These antibodies were detected more often than antiphospholipid antibodies (p<0.05). Antibodies to chorionic gonadotropin (IgM, IgG) and gonadotropin-releasing hormone (IgG) were associated with threatened abortion. According to ROC analysis, their measurements were diagnostically significant in this pathology (AUC>0.8). Subclasses IgG1 and IgG2 predominated among IgG to chorionic gonadotropin. Presumably, antibodies to chorionic gonadotropin and gonadotropin-releasing hormone could serve as independent factors of threatened abortion risk during trimester I.
authors.affiliation: V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, the Ministry of Health of Russia, Moscow, Russia, i_menzhinskaya@oparina4.ru.
authors.forename: I V
authors.initials: IV
authors.lastname: Menzhinskaya
authors.forename: L V
authors.initials: LV
authors.lastname: Van'ko
authors.forename: P A
authors.initials: PA
authors.lastname: Kiryushchenkov
authors.forename: M A
authors.initials: MA
authors.lastname: Tambovtseva
authors.forename: M M
authors.initials: MM
authors.lastname: Kashentseva
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000033:Abortion, Threatened / Q000276:immunology*; D000328:Adult; D019540:Area Under Curve; D006063:Chorionic Gonadotropin / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D011247:Pregnancy; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D006063:Chorionic Gonadotropin; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007987:Gonadotropin-Releasing Hormone