title: A crystal structure of an oligoproline PPII-helix, at last.
abstract: The first crystal structure of an oligoproline adopting an all-trans polyproline II (PPII) helix is presented. The high-resolution structure provides detailed insight into the dimensions and conformational properties of oligoprolines that are important for, e.g., their use as "molecular rulers" and "molecular scaffolds". The structure also showed that the amides interact with each other within a PPII helix and that water is not necessary for PPII helicity.
authors.affiliation: Laboratory of Organic Chemistry, ETH Zurich , Vladimir-Prelog-Weg 3, CH-8093 Zurich, Switzerland.
authors.forename: Patrick
authors.initials: P
authors.lastname: Wilhelm
authors.forename: Bartosz
authors.initials: B
authors.lastname: Lewandowski
authors.forename: Nils
authors.initials: N
authors.lastname: Trapp
authors.forename: Helma
authors.initials: H
authors.lastname: Wennemers
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D010455:Peptides; C011083:polyproline