title: Novel insights into the electrochemical detection of nitric oxide in biological systems.
abstract: In recent years, microsensor technologies have made a rapid expansion into different fields of physical sciences, engineering, and biomedicine. For analyses of various biomolecules, novel sensors and detection platforms in the electrochemical field have been reported recently. The most important applications based on microelectromechanical systems dramatically reduce the need of manipulation steps with samples, while improving data quality and quantitative capabilities. This is also the case of a special class of electrochemical sensors that allow direct, real-time and non-invasive measurements of nitric oxide, whose determination is crucial for the purposes of basic research, as well as of preclinical and clinical studies. Therefore, this minireview will focus on the description of recent discoveries in the electrochemical determination of nitric oxide, released in different in vitro systems.
authors.affiliation: Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. i., Brno, Czech Republic.
authors.forename: M
authors.initials: M
authors.lastname: Pekarová
authors.affiliation: Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. i., Brno, Czech Republic.
authors.forename: A
authors.initials: A
authors.lastname: Lojek
authors.affiliation: Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Hrbáč
authors.affiliation: Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Kuchta
authors.affiliation: Faculty of Electrical Engineering and Communication, Brno University of Technology, Brno, Czech Republic.
authors.forename: J
authors.initials: J
authors.lastname: Kadlec
authors.affiliation: Department of Physical Chemistry, Faculty of Science, Palacky University, Olomouc, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Kubala
mesh_terms: D000818:Animals; D002244:Carbon / Q000737:chemistry; D002477:Cells / Q000378:metabolism*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D002244:Carbon