title: Acute eosinophilic and neutrophilic pneumonia following transarterial chemoembolization with drug-eluting beads loaded with doxorubicin for hepatocellular carcinoma: a case report.
abstract: At an intermediate or advanced stage, i.e. stage B or C, based on the Barcelona Clinic Liver Cancer classification of hepatocellular carcinoma (HCC), transarterial chemoembolization (TACE) may be offered as a treatment of palliative intent. We report the case of a patient suffering from acute respiratory distress syndrome after TACE with drug-eluting beads loaded with doxorubicin for HCC. To our knowledge, this is the first case described where a bronchoalveolar lavage was performed, and where significant levels of alveolar eosinophilia and neutrophilia were evident, attributed to a pulmonary toxicity of doxorubicin following liver chemoembolization.
authors.affiliation: Department of Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Dimitra
authors.initials: D
authors.lastname: Alifakioti
authors.forename: Cécile
authors.initials: C
authors.lastname: Daccord
authors.forename: Yann
authors.initials: Y
authors.lastname: Lachenal
authors.forename: Jean-William
authors.initials: JW
authors.lastname: Fitting
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D018893:Bronchoalveolar Lavage; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D016461:Chemoembolization, Therapeutic / Q000009:adverse effects* / Q000295:instrumentation; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects*; D004343:Drug Implants; D004802:Eosinophilia / Q000209:etiology*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D011014:Pneumonia / Q000209:etiology*
chemical_list: D000903:Antibiotics, Antineoplastic; D004343:Drug Implants; D004317:Doxorubicin