title: REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES.
abstract: Regioselective three-component reactions of aromatic aldehydes with indazol-5-amine and 2-hydroxy-1,4-naphthoquinone in HOAc under microwave irradiation have been developed. In this one-pot reaction, a series of new pyrazole-fused benzo[h]acridine derivatives with 1,2-diketone unit were synthesized with high chemical yields. The resulting pyrazole-fused acridines were employed to further react with aldehydes and ammonium acetate to give polycyclic oxazole-fused pyrazolo[3,4-j]acridines. The present green synthesis shows several advantages including operational simplicity and fast reaction rates, which makes it a useful and attractive process of library generation for drug discovery.
authors.affiliation: School of Basic Education Sciences, Xuzhou Medical College, Jiangsu, 221000, P. R. China.
authors.forename: Jin-Peng
authors.initials: JP
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu, 221116, P. R. China.
authors.forename: Wei
authors.initials: W
authors.lastname: Fan
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu, 221116, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu, 221116, P. R. China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu, 221116, P. R. China.
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA ; Institute of Chemistry & BioMedical Sciences, Nanjing University, Nanjing 210093, P. R. China.
authors.forename: Guigen
authors.initials: G
authors.lastname: Li