title: The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model.
abstract: Exposure to total-body radiation induces hematological changes, which can detriment one's immune response to wounds and infection. Here, the decreases in blood cell counts after acute radiation doses of γ-ray or proton radiation exposure, at the doses and dose-rates expected during a solar particle event (SPE), are reported in the ferret model system. Following the exposure to γ-ray or proton radiation, the ferret peripheral total white blood cell (WBC) and lymphocyte counts decreased whereas neutrophil count increased within 3 hours. At 48 hours after irradiation, the WBC, neutrophil, and lymphocyte counts decreased in a dose-dependent manner but were not significantly affected by the radiation type (γ-rays verses protons) or dose rate (0.5 Gy/minute verses 0.5 Gy/hour). The loss of these blood cells could accompany and contribute to the physiological symptoms of the acute radiation syndrome (ARS).
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: Jenine K
authors.initials: JK
authors.lastname: Sanzari
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: X Steven
authors.initials: XS
authors.lastname: Wan
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: Gabriel S
authors.initials: GS
authors.lastname: Krigsfeld
authors.affiliation: Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA.
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Wroe
authors.affiliation: Department of Radiation Medicine, Radiation Research Laboratories, Loma Linda University and Medical Center, Loma Linda, CA.
authors.forename: Daila S
authors.initials: DS
authors.lastname: Gridley
authors.affiliation: Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
authors.forename: Ann R
authors.initials: AR
authors.lastname: Kennedy
keywords: Hematology; Hematopoietic Cells; Radiation