title: [Clinicopathologic features and prognosis of primary bone anaplastic large cell lymphoma].
abstract: OBJECTIVE
  To study the clinicopathologic features, differential diagnosis and prognosis of primary bone anaplastic large cell lymphoma(ALCL).
  
  
  METHODS
  Twelve patients diagnosed with primary bone ALCL were retrospectively reviewed. The clinicopathologic features, immunohistochemic findings and results of in situ hybridization for EB virus were analyzed.
  
  
  RESULTS
  Of the 12 patients, the male-to-female was 7: 5 with a median age of 17.5 years (range from 9 to 64 years). Bone pain was the presenting symptom in all patients. Radiographic examination demonstrated solitary osteolytic lesion in 8 patients and multiple lesions in the rest 4 patients. Spine (7 cases) was the most common site to be involved, followed by ilium (5 cases), sacrum (2 cases), humerus (1 case) and collarbone (1 case). Ten patients were available with the follow-up data including 5 ALK-positive and 5 ALK-negative patients, and the follow-up time was 2 to 47 months. Interestingly, the 3 dead patients were ALK-negative whereas 5 of 7 ALK-positive patients achieved remission.
  
  
  CONCLUSIONS
  Primary bone ALCL is a rare type of non-Hodgkin lymphoma and it more frequently involves the axial skeleton. Boys and young males are more commonly affected. Patients usually present at an early stage and have a relatively favorable prognosis. Expression of ALK protein may be associated with a favorable prognosis in primary bone ALCL.
authors.affiliation: Department of Pathology, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Guohua
authors.initials: G
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Ding
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Wang
authors.forename: Yumei
authors.initials: Y
authors.lastname: Lai
authors.forename: Cuiling
authors.initials: C
authors.lastname: Liu
authors.affiliation: E-mail: wjshgao@bjmu.edu.cn.
authors.forename: Zifen
authors.initials: Z
authors.lastname: Gao
mesh_terms: D030201:Activin Receptors, Type I; D000293:Adolescent; D000328:Adult; D000469:Alkaline Phosphatase; D001847:Bone Diseases / Q000209:etiology; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000201:enzymology / Q000401:mortality; D002648:Child; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000000981:diagnostic imaging / Q000201:enzymology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D011379:Prognosis; D011859:Radiography; D020794:Receptor Protein-Tyrosine Kinases; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D020794:Receptor Protein-Tyrosine Kinases; C424205:ACVR1C protein, human; D030201:Activin Receptors, Type I; D000469:Alkaline Phosphatase