title: Association between retinol binding protein 4 with atherosclerotic markers in obese children.
abstract: BACKGROUND
  Childhood obesity increases cardiovascular risk during adulthood. Retinol-binding protein-4, a pro-inflammatory adipokine, associated with obesity and insulin resistance also plays a role in atherogenesis in adults. The goal of this study was to identify the relation between RBP4 and atherogenic markers in obese children.
  
  
  METHODS
  In a cross-sectional study, obese and non-obese children (8-18 years) were prospectively recruited from a pediatric Appalachian population. Clinical markers such as lipid profile, HbA1c, markers of insulin resistance and plasma levels of RBP4, sVCAM-1 and oxidized-low-density lipoprotein (Ox-LDL) were measured.
  
  
  RESULTS
  Compared to non-obese children, RBP4 (P=0.016) and Ox-LDL (P<0.001) were significantly higher in obese children and were positively correlated with Body Mass Index (P<0.001), BMI-SDS (Standard-Deviation Score) (P<0.001) and waist circumference (P=0.03).
  
  
  CONCLUSIONS
  No significant correlation was found between inflammatory markers and Homeostatic Model Assessment-2, HDL, triglycerides, and HbA1c in obese children.
authors.affiliation: Department of Pharmacology, Physiology and Toxicology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV, USA - santanam@marshall.edu.
authors.forename: Nalini
authors.initials: N
authors.lastname: Santanam
authors.forename: Yoram
authors.initials: Y
authors.lastname: Elitsur
authors.forename: Ronald
authors.initials: R
authors.lastname: Stanek
authors.forename: Mateen
authors.initials: M
authors.lastname: Hotiana
authors.forename: Jennifer
authors.initials: J
authors.lastname: Wheaton
authors.forename: Reem
authors.initials: R
authors.lastname: Kheetan
authors.forename: Randa
authors.initials: R
authors.lastname: Aljayoussi
authors.forename: Todd
authors.initials: T
authors.lastname: Gress
authors.forename: Abid
authors.initials: A
authors.lastname: Yaqub
mesh_terms: D000293:Adolescent; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D063766:Pediatric Obesity / Q000097:blood* / Q000150:complications; D011627:Puberty; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*
chemical_list: D015415:Biomarkers; D008077:Lipoproteins, LDL; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma