title: Multipinhole collimator with 20 apertures for a brain SPECT application.
abstract: OBJECTIVE
  Several new technologies for single photon emission computed tomography (SPECT) instrumentation with parallel-hole collimation have been proposed to improve detector sensitivity and signal collection efficiency. Benefits from improved signal efficiency include shorter acquisition times and lower dose requirements. In this paper, the authors show a possibility of over an order of magnitude enhancement in photon detection efficiency (from 7.6 × 10(-5) to 1.6 × 10(-3)) for dopamine transporter (DaT) imaging of the striatum over the conventional SPECT parallel-hole collimators by use of custom-designed 20 multipinhole (20-MPH) collimators with apertures of 0.75 cm diameter.
  
  
  METHODS
  Quantifying specific binding ratio (SBR) of (123)I-ioflupane or (123)I-iometopane's signal at the striatal region is a common brain imaging method to confirm the diagnosis of the Parkinson's disease. The authors performed imaging of a striatal phantom filled with aqueous solution of I-123 and compared camera recovery ratios of SBR acquired between low-energy high-resolution (LEHR) parallel-hole collimators and 20-MPH collimators.
  
  
  RESULTS
  With only two-thirds of total acquisition time (20 min against 30 min), a comparable camera recovery ratio of SBR was achieved using 20-MPH collimators in comparison to that from the LEHR collimator study.
  
  
  CONCLUSIONS
  Their systematic analyses showed that the 20-MPH collimator could be a promising alternative for the DaT SPECT imaging for brain over the traditional LEHR collimator, which could give both shorter scan time and improved diagnostic accuracy.
authors.affiliation: Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107.
authors.forename: Tzu-Cheng
authors.initials: TC
authors.lastname: Lee
authors.affiliation: Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107.
authors.forename: Justin R
authors.initials: JR
authors.lastname: Ellin
authors.affiliation: School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Qiu
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107.
authors.forename: Uttam
authors.initials: U
authors.lastname: Shrestha
authors.affiliation: Department of Radiotracer Development and Imaging Technology, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94702.
authors.forename: Grant T
authors.initials: GT
authors.lastname: Gullberg
authors.affiliation: Physics Research Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94107.
authors.forename: Youngho
authors.initials: Y
authors.lastname: Seo
mesh_terms: D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology*; D004298:Dopamine / Q000737:chemistry; D050483:Dopamine Plasma Membrane Transport Proteins / Q000737:chemistry; D004867:Equipment Design; D006801:Humans; D007457:Iodine Radioisotopes / Q000737:chemistry; D010300:Parkinson Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D059629:Signal-To-Noise Ratio; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D004298:Dopamine