title: Hybrid ZnO nanorod-polymer brush hierarchically nanostructured substrate for sensitive antibody microarrays.
abstract: A hierarchically nanostructured organic-inorganic hybrid substrate comprising randomly oriented ZnO nanorods on glass slide with coaxially tethered dense polymer brush, POEGMA-co-GMA is reported for highly sensitive antibody microassay, achieving excellent detection specificity, and superior detection limit of as low as 100 fg mL(-1) for biomarkers in human serum within a 1 h assay time.
authors.affiliation: Institute for Clean energy & Advanced Materials, Faculty of Materials and Energy, Southwest University, Chongqing, 400715, China; Chongqing Key Laboratory for Advanced Materials and Technologies of Clean Energies, Chongqing, 400715, China; Chongqing Engineering Research Center for Rapid diagnosis of Fatal Diseases, Chongqing, 400715, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Hu
authors.forename: Yingshuai
authors.initials: Y
authors.lastname: Liu
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Chang Ming
authors.initials: CM
authors.lastname: Li
mesh_terms: D000906:Antibodies / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods; D004852:Epoxy Compounds / Q000737:chemistry; D005453:Fluorescence; D005898:Glass / Q000737:chemistry; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods; D008689:Methacrylates / Q000737:chemistry; D046228:Microarray Analysis / Q000295:instrumentation* / Q000379:methods; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids; D012680:Sensitivity and Specificity; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D000906:Antibodies; D015415:Biomarkers; D004852:Epoxy Compounds; D008689:Methacrylates; D011108:Polymers; D011109:Polymethacrylic Acids; C528061:poly(poly(ethylene glycol)methacrylate); D011092:Polyethylene Glycols; C007870:glycidyl methacrylate; D015034:Zinc Oxide
keywords: Antibody Microarray; Cancer Biomarker; Nanostructured Substrate; Polymer Brush; ZnO Nanorod