title: [Pharmacological characteristics of glycine receptors in rat hippocampal pyramidal cells].
abstract: OBJECTIVE
  To investigate function of glycine receptors (GlyRs) at the hippocampal CA1 pyramidal cells and to characterize the pharmacological properties of these receptors at early postnatal stage.
  
  
  METHODS
  We used whole cell patch clamp recording to study the current response in the acutely prepared hippocampal slices from postnatal day 11-13 rats induced by glycine applied in the artificial cerebrospinal fluid.
  
  
  RESULTS
  Application of glycine to the pyramidal cells elicited strychnine sensitive chloride currents. EC50 for GlyRs respond to glycine was 123. 23 μmol/L and Hill coefficient was 1.24. Picrotoxin could partly blocked the currents.
  
  
  CONCLUSIONS
  Strychnine sensitive glycine receptors are functionally expressed in CA1 pyramidal neurons in rat hippocampal CA1 area at early postnatal stage, and some of GlyRs are αβ heteromeric receptors.
authors.affiliation: Department of Physiology and Pathophysiology, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Meng
authors.forename: Wen
authors.initials: W
authors.lastname: Xie
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000166:cytology*; D005998:Glycine / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D017966:Pyramidal Cells / Q000187:drug effects*; D051381:Rats; D018009:Receptors, Glycine / Q000378:metabolism*; D013331:Strychnine / Q000494:pharmacology
chemical_list: D018009:Receptors, Glycine; D013331:Strychnine; D005998:Glycine