title: Direct and remote constriction of membrane necks.
abstract: The physical properties of membrane necks are relevant in vesiculation, a process that plays an essential role in cellular physiology. Because the neck's radius is, in general, finite, membrane scission and the consequent pinching off of the vesicle can only occur if it is narrowed to permit the necessary membrane topological reformation. Here we examine, in a simple single phase lipid vesicle, how external forces can promote neck constriction not only by direct compression at the neck but also, counterintuitively, by dilation at remote locations. These results provide a new perspective on the role played by actin polymerization in the process of endocytosis.
authors.affiliation: Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia.
authors.forename: Bojan
authors.initials: B
authors.lastname: Božič
authors.affiliation: Instituto de Ciencias Nucleares, Universidad Nacional Autónoma de México, México D.F., Mexico.
authors.forename: Jemal
authors.initials: J
authors.lastname: Guven
authors.affiliation: Department of Physics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.
authors.forename: Pablo
authors.initials: P
authors.lastname: Vázquez-Montejo
authors.affiliation: Institute of Biophysics, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, SI-1000 Ljubljana, Slovenia and Jožef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia.
authors.forename: Saša
authors.initials: S
authors.lastname: Svetina
mesh_terms: D000199:Actins / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology*; D004705:Endocytosis / Q000502:physiology*; D008051:Lipid Bilayers / Q000737:chemistry; D008954:Models, Biological; D058105:Polymerization; D022161:Transport Vesicles / Q000502:physiology*
chemical_list: D000199:Actins; D008051:Lipid Bilayers