title: Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air.
abstract: A catalytic decarboxylative annulation has been developed for the regioselective synthesis of trisubstituted furans by the cycloaddition of ketones with α,β-unsaturated carboxylic acids under ambient air. A library of furan derivatives were obtained in good yields from the readily available substrates in the combination of a catalytic amount of Cu-salt and a stoichiometric amount of water. Water plays a crucial role in this catalytic transformation.
authors.affiliation: Department of Chemistry, Visva-Bharati University, Santiniketan-731235, India. alakananda.hajra@visva-bharati.ac.in.
authors.forename: Monoranjan
authors.initials: M
authors.lastname: Ghosh
authors.forename: Subhajit
authors.initials: S
authors.lastname: Mishra
authors.forename: Kamarul
authors.initials: K
authors.lastname: Monir
authors.forename: Alakananda
authors.initials: A
authors.lastname: Hajra
mesh_terms: D000388:Air; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D061565:Cycloaddition Reaction; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D005663:Furans; D007659:Ketones; D014867:Water; D003300:Copper; C039281:furan