title: Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine.
abstract: Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.
authors.affiliation: Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Chiyoda-ku, Tokyo 102-8554, Japan. t-usuki@sophia.ac.jp.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Rina
authors.initials: R
authors.lastname: Suzuki
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yanuma
authors.forename: Jiangtao
authors.initials: J
authors.lastname: He
authors.forename: Shuren
authors.initials: S
authors.lastname: Ma
authors.forename: Gerard M
authors.initials: GM
authors.lastname: Turino
authors.forename: Yong Y
authors.initials: YY
authors.lastname: Lin
authors.forename: Toyonobu
authors.initials: T
authors.lastname: Usuki
mesh_terms: D015415:Biomarkers / Q000032:analysis; D002853:Chromatography, Liquid; D003895:Desmosine / Q000032:analysis* / Q000138:chemical synthesis; D004549:Elastin / Q000737:chemistry*; D008968:Molecular Conformation; D053719:Tandem Mass Spectrometry
chemical_list: D015415:Biomarkers; D003895:Desmosine; D004549:Elastin