title: Total synthesis of biologically active natural products based on highly selective synthetic methodologies.
abstract: Total syntheses of structurally and biologically intriguing natural products relying on new synthetic methodologies are described. This article features cinchona alkaloid-catalyzed asymmetric Morita-Baylis-Hillman reactions, heterocycle syntheses based on rhodium-catalyzed C-H amination and indium-catalyzed Conia-ene reactions, and their utilization for the syntheses of the phoslactomycin family of antibiotics, glutamate receptor agonists and antagonists, and alkaloids with characteristic highly substituted pyrrolidinone core structures.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D002930:Cinchona Alkaloids / Q000737:chemistry; D018683:Excitatory Amino Acid Agents / Q000138:chemical synthesis* / Q000737:chemistry; D018690:Excitatory Amino Acid Agonists / Q000138:chemical synthesis / Q000737:chemistry; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis / Q000737:chemistry; D007204:Indium / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D001688:Biological Products; D002930:Cinchona Alkaloids; D018683:Excitatory Amino Acid Agents; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D007783:Lactones; D007204:Indium; D012238:Rhodium