title: Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 concentrations in children with obstructive sleep apnea-hypopnea syndrome.
abstract: BACKGROUND
  The aim of this study was to assess insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) concentrations in children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to compare the results according to disease severity and duration.
  
  
  METHODS
  Fifty-one children with OSAHS underwent polysomnography and were classified as having mild, moderate, or severe disease. All children underwent bilateral tonsillectomy/adenoidectomy or adenoidectomy. IGF-1 and IGFBP-3 concentrations were assessed before surgery and 3 and 6 months after surgery.
  
  
  RESULTS
  Before surgery, IGF-1 and IGFBP-3 concentrations were significantly higher (P < .05) in the < 5-y group (125.20 ± 42.38 μg/L and 2.00 ± 0.54 mg/L) compared with the ≥ 5-y group (61.92 ± 19.07 μg/L and 1.20 ± 0.37 mg/L). After surgery, concentrations significantly increased (P < .05) in both groups, but remained lower in the ≥ 5-y group. Before surgery, there were no significant differences in IGF-1 (mild: 93.82 ± 37.52 mg/L; moderate: 109.06 ± 58.42 mg/L; severe: 73.88 ± 28.51 mg/L) and IGFBP-3 (mild: 1.76 ± 0.57 mg/L; moderate: 1.67 ± 0.72 mg/L; severe: 1.33 ± 0.45 mg/L) concentrations by severity. After surgery, concentrations significantly increased (P < .05) in both groups, but did not differ by severity. After adjusting for time after surgery, disease duration, apnea-hypopnea index, time spent at SpO2 < 90%, and body mass index Z score, IGF-1 and IGFBP-3 concentrations significantly decreased with every year of age.
  
  
  CONCLUSIONS
  These results suggest that disease duration, but not severity, affects the concentrations of 2 important mediators of growth/development (IGF-1 and IGFBP-3) in children with OSAHS before and after surgery.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery zhujin2698@163.com.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Zhongda Hospital (affiliated with Southeast University), Nanjing, China.
authors.forename: Hai-Fei
authors.initials: HF
authors.lastname: Wang
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery.
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.affiliation: Gene Laboratory, Hangzhou First People's Hospital (affiliated with Nanjing Medical University), Zhejiang, China.
authors.forename: Dao-Jun
authors.initials: DJ
authors.lastname: Yu
authors.affiliation: School of Public Health, Zhejiang University, Zhejiang, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Shen
mesh_terms: D000233:Adenoidectomy; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D017286:Polysomnography; D011184:Postoperative Period; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery; D013997:Time Factors; D014068:Tonsillectomy
chemical_list: C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
keywords: children; development; disease; duration; growth; obstructive sleep apnea-hypopnea syndrome; pediatric; severity