title: Palladium-catalyzed cross-coupling of benzyl chlorides with cyclopropanol-derived ketone homoenolates.
abstract: The palladium-catalyzed cross-coupling reaction of cyclopropanol-derived ketone homoenolates with benzyl chlorides is reported. This reaction proceeds in high yields with electron-neutral and electron-rich benzyl chlorides; however, yields are low with electron-poor benzyl chlorides. In addition, a range of cyclopropanols can be coupled in good yields. The reaction can be conducted with a low catalyst loading (1% Pd) and on a gram scale without reduction in yield.
authors.affiliation: Department of Chemistry, York University 4700 Keele Street, Toronto, ON M3J 1P3, Canada.
authors.forename: Nisha
authors.initials: N
authors.lastname: Nithiy
authors.forename: Arturo
authors.initials: A
authors.lastname: Orellana