title: A folic acid conjugated silica-titania porous hollow nanosphere for improved topical photodynamic therapy.
abstract: The folic acid conjugated hollow nanosphere is used to encapsulate protoporphyrin IX and is utilized for photodynamic therapy. This system represents a 3.33 times higher photodynamic efficiency than previous protoporphyrin IX-based systems. The result proposes a new opportunity for effective photodynamic therapy of folate receptor positive tumor cells.
authors.affiliation: World Class University (WCU) Program of Chemical Convergence for Energy & Environment (C2E2) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea. jsjang@plaza.snu.ac.kr.
authors.forename: Yoonsun
authors.initials: Y
authors.lastname: Jang
authors.forename: Sojin
authors.initials: S
authors.lastname: Kim
authors.forename: Wan-Kyu
authors.initials: WK
authors.lastname: Oh
authors.forename: Chanhoi
authors.initials: C
authors.lastname: Kim
authors.forename: Inkyu
authors.initials: I
authors.lastname: Lee
authors.forename: Jyongsik
authors.initials: J
authors.lastname: Jang
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism; D005492:Folic Acid / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D046529:Microscopy, Electron, Transmission; D054118:Nanospheres / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry*; D016062:Porosity; D011524:Protoporphyrins / Q000008:administration & dosage / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012822:Silicon Dioxide / Q000737:chemistry*; D014025:Titanium / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D058973:Folate Receptors, GPI-Anchored; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D017382:Reactive Oxygen Species; C009495:titanium dioxide; D012822:Silicon Dioxide; D005492:Folic Acid; C028025:protoporphyrin IX; D014025:Titanium