title: Comparatve uric acid lowering studies of allopurinol with an indigenous medicinal plant in rabbits.
abstract: The aim of this research was to carry out a comparative study of lowering of uric acid by the use of dried powder of Colchicum luteum and allopathic drug (allopurinol) in rabbits, to determine whether herbal drugs can be used by patients instead of allopathic drugs. The herbal medicine, dried corm powder of Colchicum luteum 2.5 mg/kg/day and dried powder of allopurinol 2 mg/kg/day an allopathic medicine, was used in the study. The results of these medicines were observed in animal model, using 12 adult rabbits, which were divided into three groups A, B and C, respectively, where group C was taken as control. The SPSS version 17 was used for statistical analysis and analysis of variance (ANOVA) was used for comparing the data in different groups and the level of significance was 5%. It was resulted that dried corm of Colchicum luteum significantly reduced the uric acid in adult rabbits as reduced by allopathic medicine--allopurinol. In the light of present research we concluded that the herbal medicines can be used in lieu of allopathic drugs. Thus, the risk of side effects that are associated with the prolonged use of allopathic drugs can be minimized.
authors.forename: Imran Shair
authors.initials: IS
authors.lastname: Mohammad
authors.forename: Sana
authors.initials: S
authors.lastname: Latif
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yar
authors.forename: Faiza
authors.initials: F
authors.lastname: Nasar
authors.forename: Irshad
authors.initials: I
authors.lastname: Ahmad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Naeem
mesh_terms: D000493:Allopurinol / Q000494:pharmacology*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D003079:Colchicum; D004195:Disease Models, Animal; D015536:Down-Regulation; D005632:Fructose; D006074:Gout Suppressants / Q000494:pharmacology*; D033461:Hyperuricemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011208:Powders; D011817:Rabbits; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D006074:Gout Suppressants; D010936:Plant Extracts; D011208:Powders; D014527:Uric Acid; D005632:Fructose; D000493:Allopurinol