title: Susceptibility and REF1 gene polymorphism towards colorectal cancer.
abstract: Published data on the relation between REF1 polymorphism and colorectal cancer risk showed inconclusive results. The aim of this study was to derive a comprehensive estimation of the association. Data on association between REF1 polymorphism and colorectal cancer risk were summarized. The association was estimated by calculating an odds ratio (OR) with corresponding 95 % confidence interval (95 % CI) with the fixed effects model when P > 0.1 (from heterogeneity test) or with the random effects model when P < 0.1. No significant association was revealed in any genetic model assumed for the overall analysis (OR = 1.03, 95 % CI = 0.81-1.32 for Glu/Glu vs. Asp/Asp; OR = 1.05, 95 % CI = 0.96-1.15 for Glu/Glu + Asp/Glu vs. Asp/Asp; OR = 0.97, 95 % CI = 0.76-1.23 for Glu/Glu vs. Asp/Glu + Asp/Asp; OR = 1.03, 95 % CI = 0.92-1.16 for Glu vs. Asp; OR = 1.09, 95 % CI = 0.93-1.27 for Asp/Glu vs. Asp/Asp). In Caucasian population, nor did we find a significant association. This research indicates that REF1 polymorphism is unlikely to be associated with colorectal cancer risk.
authors.affiliation: Department of Gastrointestinal and Pancreatic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510700, Guangdong, China.
authors.forename: Shibin
authors.initials: S
authors.lastname: Yang
authors.forename: Yuanhui
authors.initials: Y
authors.lastname: Lai
authors.forename: Longbin
authors.initials: L
authors.lastname: Xiao
authors.forename: Fanghai
authors.initials: F
authors.lastname: Han
authors.forename: Wenhui
authors.initials: W
authors.lastname: Wu
authors.forename: Shuo
authors.initials: S
authors.lastname: Long
authors.forename: Wenfeng
authors.initials: W
authors.lastname: Li
authors.forename: Yulong
authors.initials: Y
authors.lastname: He
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase