title: Intravoxel incoherent motion magnetic resonance imaging findings in the acute phase of MELAS: a case report.
abstract: OBJECTIVE
  We report the clinical application of intravoxel incoherent motion (IVIM) magnetic resonance (MR) imaging to diagnose a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) in the acute phase.
  
  
  RESULTS
  On IVIM MR Images of this patient, higher perfusion (f) and diffusion (D) values in the left occipital and temporal lobes were found compared to the contralateral areas.
  
  
  CONCLUSIONS
  These findings imply a breakdown of autoregulation with hyperperfusion and vasogenic edema during the acute phase of MELAS, as described in previous reports. IVIM imaging is a valuable, noninvasive tool that simultaneously quantifies perfusion and diffusion parameters.
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uehara
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Yamashita
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Hiwatashi
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Togao
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Kikuchi
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Yokoyama
authors.affiliation: Department of Neurology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Dai
authors.initials: D
authors.lastname: Matsuse
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshiura
authors.affiliation: Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University 3-1-1, Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honda
mesh_terms: D000208:Acute Disease; D002560:Cerebrovascular Circulation; D006801:Humans; D017241:MELAS Syndrome / Q000175:diagnosis* / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009778:Occipital Lobe / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology*; D055815:Young Adult
keywords: Diffusion MRI; IVIM; MELAS; perfusion MRI