title: Use of hyaluronidase as an adjuvant to ropivacaine to reduce axillary brachial plexus block onset time: a prospective, randomised controlled study.
abstract: When considering brachial plexus block as a practical alternative to general anaesthesia for upper limb surgery, the time to achieve complete sensory block is a clinically important variable. In this prospective randomised double-blind controlled trial, we investigated the hypothesis that addition of hyaluronidase to ropivacaine may reduce the time to achieve complete sensory block after axillary brachial plexus block. The patients were randomly assigned into a hyaluronidase group (n = 24) and a control group (n = 24). The hyaluronidase group received ropivacaine 0.5% with 100 IU.ml(-1) of hyaluronidase, and the control group received ropivacaine alone. The primary endpoint was the time to achieve complete sensory block. The hyaluronidase group demonstrated significantly shorter mean (SD) sensory block onset time (13.8 (6.0) min) compared with the control group (22.5 (6.3) min, p < 0.0001). Addition of hyaluronidase to ropivacaine resulted in a reduction in the time needed to achieve complete sensory block.
authors.affiliation: Department of Anesthesiology and Pain Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
authors.forename: W U
authors.initials: WU
authors.lastname: Koh
authors.forename: H G
authors.initials: HG
authors.lastname: Min
authors.forename: H S
authors.initials: HS
authors.lastname: Park
authors.forename: M H
authors.initials: MH
authors.lastname: Karm
authors.forename: K K
authors.initials: KK
authors.lastname: Lee
authors.forename: H S
authors.initials: HS
authors.lastname: Yang
authors.forename: Y J
authors.initials: YJ
authors.lastname: Ro
mesh_terms: D000577:Amides / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001917:Brachial Plexus / Q000187:drug effects*; D065527:Brachial Plexus Block / Q000379:methods*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000077212:Ropivacaine; D013997:Time Factors
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D004338:Drug Combinations; D000077212:Ropivacaine; D006821:Hyaluronoglucosaminidase