title: Temporal characteristics of stress-induced decrease in benzodiazepine reception in C57BL/6 and BALB/c mice.
abstract: We studied the duration of the drop of specific (3)H-flunitrazepam binding by synaptosomal membranes from the brain of C57Bl/6 and BALB/c mice after open-field and "contact with predator" tests. It was found that reduced benzodiazepine reception in BALB/c mice after open-field test persisted for 1.5 h, but no changes of this parameter were found in C57Bl/6 mice. After contact with predator, the binding capacity of the benzodiazepine site of GABAA receptor was reduced for 8 h in BALB/c mice and for 24 h in C57Bl/6 mice.
authors.affiliation: Department of Pharmacogenetics, V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia, doctorpharm@mail.ru.
authors.forename: M A
authors.initials: MA
authors.lastname: Yarkova
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005445:Flunitrazepam / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000378:metabolism* / Q000502:physiology; D008810:Mice, Inbred C57BL / Q000378:metabolism* / Q000502:physiology; D011963:Receptors, GABA-A / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000502:physiology*; D013574:Synaptosomes / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011963:Receptors, GABA-A; D001569:Benzodiazepines; D005445:Flunitrazepam