title: Corrosion-controlling and osteo-compatible Mg ion-integrated phytic acid (Mg-PA) coating on magnesium substrate for biodegradable implants application.
abstract: Biodegradable, a new revolutionary concept, is shaping the future design of biomedical implants that need to serve only as a temporary scaffold. Magnesium appears to be the most promising biodegradable metal, but challenges remain in its corrosion-controlling and uncertain biocompatibility. In this work, we employ chemical conversion and alternating dip-coating methods to anchor and deposit an Mg ion-integrated phytic acid (Mg-PA) coating on Mg, which is supposed to function both corrosion-controlling and osteo-compatible. It was ascertained that PA molecules were covalently immobilized on a chemically converted Mg(OH)2 base layer, and more PA molecules were deposited subsequently via chelating reactions with the help of additive Mg ions. The covalent immobilization and the Mg ion-supported chelating deposition contribute to a dense and homogeneous protective Mg-PA coating, which guarantees an improved corrosion resistance as well as a reduced degradation rate. Moreover, the Mg-PA coating performed osteo-compatible to promote not only bioactivity of bonelike apatite precipitation, but also induced osteoblast cells adhesion and proliferation. This is ascribed to its nature of PA molecule and the biocompatible Mg ion, both of which mimic partly the compositional structure of bone. Our magnesium ion-integrated PA-coated Mg might bode well for the future of biodegradable bone implant application.
authors.affiliation: Key Laboratory of Advanced Technologies of Materials, Ministry of Education, College of Materials Science and Engineering, Southwest Jiaotong University , Chengdu 610031, China.
authors.forename: Yingqi
authors.initials: Y
authors.lastname: Chen
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhao
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.forename: Meiyun
authors.initials: M
authors.lastname: Chen
authors.forename: Jinlong
authors.initials: J
authors.lastname: Mao
authors.forename: Hairuo
authors.initials: H
authors.lastname: He
authors.forename: Yuancong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Nan
authors.initials: N
authors.lastname: Huang
authors.forename: Guojiang
authors.initials: G
authors.lastname: Wan
mesh_terms: D020341:Absorbable Implants; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003343:Corrosion; D007477:Ions / Q000737:chemistry; D008274:Magnesium / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010833:Phytic Acid / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D007477:Ions; D010833:Phytic Acid; D008274:Magnesium
keywords: biodegradable metals; bone implants; corrosion; magnesium; osteo-biocompatibility; phytic acid