title: Evaluation of body composition changes, epicardial adipose tissue, and serum omentin-1 levels in overt hypothyroidism.
abstract: Our aim was to investigate body composition changes, epicardial adipose tissue thickness (EATT), serum omentin-1 levels, and the relationship among them along with some atherosclerosis markers in overt hypothyroidism. Twenty-eight newly diagnosed overt hypothyroid patients were evaluated before and after 6 months of thyroid hormone replacement therapy (THRT) and compared to the healthy subjects in this prospective longitudinal study. Body compositions were measured with dual-energy X-ray absorptiometry, and EATT was measured by echocardiography. Carotid intima-media thickness (c-IMT), flow-mediated dilatation (FMD), thyroid hormone levels, lipid parameters, high sensitive c-reactive protein, homocysteine, and omentin-1 levels were measured in all subjects. Body weight and lean body mass were higher in patients with hypothyroidism compared to euthyroid state after THRT (p = 0.012, 0.034, respectively). EATT was higher in patients with hypothyroidism than the control group (p < 0.001) and decreased with THRT (p = 0.012) but still remained higher than the control group (p < 0.001). Free T4 levels were found to be an independent factor to predict EATT (p < 0.001). In hypothyroid state, omentin-1 levels were lower than controls (p = 0.037) but increased in 6 months with THRT (p = 0.001). The c-IMT was higher, and FMD was lower in hypothyroidism compared to euthyroid state and control group (p < 0.05). Increasing lean body mass, but not adipose tissue mass, was found to be responsible for weight gain in hypothyroidism. The increased amount of EATT and decreased omentin-1 levels can contribute to the development of atherosclerosis in addition to other factors in hypothyroidism.
authors.affiliation: Department of Endocrinology and Metabolism, Faculty of Medicine, Gazi University, 06500, Ankara, Turkey, ceritturgay1@yahoo.com.
authors.forename: Ethem Turgay
authors.initials: ET
authors.lastname: Cerit
authors.forename: Mujde
authors.initials: M
authors.lastname: Akturk
authors.forename: Alev E
authors.initials: AE
authors.lastname: Altinova
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tavil
authors.forename: Cigdem
authors.initials: C
authors.lastname: Ozkan
authors.forename: Cagri
authors.initials: C
authors.lastname: Yayla
authors.forename: Mustafa
authors.initials: M
authors.lastname: Altay
authors.forename: Canan
authors.initials: C
authors.lastname: Demirtas
authors.forename: Nuri
authors.initials: N
authors.lastname: Cakir
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000503:physiopathology*; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D014463:Ultrasonography
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins