title: Strokes in the anterior circulation: comparison between bridging and intravenous thrombolysis.
abstract: OBJECTIVE
  To compare safety and efficacy of bridging approach with intravenous (IV) thrombolysis in patients with acute anterior strokes and proximal occlusions.
  
  
  METHODS
  Consecutive patients with ischemic anterior strokes admitted within a 4 h 30 min window in two different centers were included. The first center performed IV therapy (alteplase 0.6 mg/kg) during 30 min and, in absence of clinical improvement, mechanical thrombectomy with flow restoration using a Solitaire stent (StS); the second carried out IV thrombolysis (alteplase 0.9 mg/kg) alone. Only T, M1 or M2 occlusions present on CT angiography were considered. Endpoints were clinical outcome and mortality at 3 months.
  
  
  RESULTS
  There were 63 patients in the bridging and 163 in the IV group. No significant differences regarding baseline characteristics were observed. At 3 months, 46% (n = 29) of the patients treated in the combined and 23% (n = 38) of those treated in the IV group had a modified Rankin scale (mRS) of 0-1 (P < 0.001). A statistical significant difference was observed for all sites of occlusion. In a logistic regression model, National Institute of Health Stroke Scale (NIHSS) and bridging therapy were independent predictors of good outcome (respectively, P = 0.001 and P = 0.0018). Symptomatic hemorrhage was documented in 6.3% vs 3.7% in the bridging and in the IV group, respectively (P = 0.32). There was no difference in mortality.
  
  
  CONCLUSIONS
  Our results suggest that patients treated with a bridging approach were more likely to have minimal or no deficit at all at 3 months as compared to the IV treated group.
authors.affiliation: Department of Neurology, Medical School, University Hospitals of Geneva, Geneva, Switzerland.
authors.forename: R F
authors.initials: RF
authors.lastname: Sztajzel
authors.forename: H
authors.initials: H
authors.lastname: Muller
authors.forename: L
authors.initials: L
authors.lastname: Sekoranja
authors.forename: A
authors.initials: A
authors.lastname: Viaccoz
authors.forename: V
authors.initials: V
authors.lastname: Mendez Pereira
authors.forename: A P
authors.initials: AP
authors.lastname: Narata
authors.forename: K
authors.initials: K
authors.lastname: Lovblad
authors.forename: S
authors.initials: S
authors.lastname: Altrichter
authors.forename: P
authors.initials: P
authors.lastname: Michel
mesh_terms: D061605:Administration, Intravenous; D000368:Aged; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D061185:Mechanical Thrombolysis / Q000379:methods*; D008875:Middle Aged; D015607:Stents; D020521:Stroke / Q000628:therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator
keywords: bridging therapy; intravenous thrombolysis; ischemic stroke; mechanical thrombectomy; proximal acute anterior circulation occlusions