title: Bosniak category III cysts are more likely to be malignant than we expected in the era of multidetector computed tomography technology.
abstract: BACKGROUND
  Complex indeterminate Bosniak category III renal cystic masses are traditionally considered to be malignant in 50%. Our aim was to retrospectively evaluate the attenuation characteristics in multiphase computed tomography (CT) and to determinate the incidence of malignancy based on histological findings on all Bosniak category III renal cystic masses investigated in our department between April 3, 2007 and November 21, 2013.
  
  
  METHODS
  QUADRIPHASIC MULTIDETECTOR CT IMAGES OF NINETEEN PATIENTS (MEAN AGE: 56.5 ± 16.5 years) with radiologically detected Bosniak category III lesions were reviewed retrospectively. All lesions were surgically removed, and the incidence of malignancy, based on pathological results was determined.
  
  
  RESULTS
  Calcification was present in four lesions (21%). The mean largest diameter was 48.7 ± 28.8 mm. All lesions were multilobulated and septated. Of the 19 removed lesions, 16 (84%) were malignant, and 3 (16%) were benign (one inflammatory cyst including a nephrolith, one cystic nephroma and one atypical angiomyolipoma). CT and histological findings of 19 Bosniak III cysts were correlated.
  
  
  CONCLUSIONS
  Our study demonstrated much higher prevalence of malignancy (84%) in radiologically detected Bosniak category III cysts than it has been described before. It may due to the era of modern multidetector CT technology and multiphase protocol.
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Pal
authors.initials: P
authors.lastname: Bata
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Adam Domonkos
authors.initials: AD
authors.lastname: Tarnoki
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: David Laszlo
authors.initials: DL
authors.lastname: Tarnoki
authors.affiliation: Department of Pathology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Attila Marcell
authors.initials: AM
authors.lastname: Szasz
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Gergely
authors.initials: G
authors.lastname: Poloskei
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Bence
authors.initials: B
authors.lastname: Fejer
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Janos
authors.initials: J
authors.lastname: Gyebnar
authors.affiliation: Department of Urology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Peter
authors.initials: P
authors.lastname: Nyirady
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Viktor
authors.initials: V
authors.lastname: Berczi
authors.affiliation: Department of Radiology and Oncotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Kinga
authors.initials: K
authors.lastname: Karlinger
authors.affiliation: Department of Urology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Attila
authors.initials: A
authors.lastname: Szendroi
keywords: Bosniak classification; computed tomography; contrast media; differential diagnosis; neoplasm; nephrology; prevalence; renal cell cancer