title: Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the ovary.
abstract: Clear cell carcinoma of the ovary (CCC) is a histologic subtype of epithelial ovarian cancer with a distinct clinical behavior. There are marked geographic differences in the prevalence of CCC. The CCC is more likely to be detected at an early stage than high-grade serous cancers, and when confined within the ovary, the prognosis is good. However, advanced disease is associated with a very poor prognosis and resistance to standard treatment. Cytoreductive surgery should be performed for patients with stage II, III, or IV disease. An international phase III study to compare irinotecan/cisplatin and paclitaxel/carboplatin as adjuvant chemotherapy for stage IIV CCC has completed enrollment (GCIG/JGOG3017). Considering the frequent PIK3CA mutation in CCC, dual inhibitors targeting PI3K, AKT in the mTOR pathway, are promising. Performing these trials and generating the evidence will require considerable international collaboration.
authors.affiliation: *Jikei University School of Medicine, Tokyo, Japan; †Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom; ‡Osaka University Graduate School of Medicine, Osaka, Japan; §Kyoto University Graduate School of Medicine, Kyoto, Japan; ∥Keio University, Tokyo, Japan; ¶Tottori University School of Medicine, Tottori, Japan; #National Defense Medical College, Saitama, Japan; **Clinical Research, Innovation, and Education Center, Tohoku University Hospital, Sendai, Japan; ††Sunnybrook Hospital, Toronto, Canada; ‡‡UCL Cancer Institute, London, United Kingdom; §§Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; ∥∥Border Medical Oncology, Victoria, Australia; ¶¶Department of Pathology, Glasgow Royal Infirmary, Glasgow, United Kingdom; ##Institute of Cancer Sciences, University of Glasgow Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, United Kingdom; ***Gynecologic Oncology Center, Kiel, Germany; †††National Cancer Center, Goyang, Korea; ‡‡‡Institut Claudius Regaud, Toulouse, France; §§§National Cancer Institute, Naples, Italy; and ∥∥∥Princess Margaret Hospital, Toronto, Canada.
authors.forename: Aikou
authors.initials: A
authors.lastname: Okamoto
authors.forename: Rosalind M
authors.initials: RM
authors.lastname: Glasspool
authors.forename: Seiji
authors.initials: S
authors.lastname: Mabuchi
authors.forename: Noriomi
authors.initials: N
authors.lastname: Matsumura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nomura
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Itamochi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takano
authors.forename: Tadao
authors.initials: T
authors.lastname: Takano
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
authors.forename: Alan
authors.initials: A
authors.lastname: Covens
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ledermann
authors.forename: Delia
authors.initials: D
authors.lastname: Mezzanzanica
authors.forename: Delia
authors.initials: D
authors.lastname: Mezzazanica
authors.forename: Christopher
authors.initials: C
authors.lastname: Steer
authors.forename: David
authors.initials: D
authors.lastname: Millan
authors.forename: Iain A
authors.initials: IA
authors.lastname: McNeish
authors.forename: Jacobus
authors.initials: J
authors.lastname: Pfisterer
authors.forename: Sokbom
authors.initials: S
authors.lastname: Kang
authors.forename: Laurence
authors.initials: L
authors.lastname: Gladieff
authors.forename: Jane
authors.initials: J
authors.lastname: Bryce
authors.forename: Amit
authors.initials: A
authors.lastname: Oza
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008495:Medical Oncology; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000628:therapy; D017410:Practice Guidelines as Topic; D012955:Societies, Medical