title: Brain-Derived Neurotrophic Factor in Alzheimer's Disease: Risk, Mechanisms, and Therapy.
abstract: Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and memory storage in hippocampus. However, changes of BDNF level and expression have been reported in the CNS as well as blood of Alzheimer's disease (AD) patients in the last decade, which indicates a potential role of BDNF in the pathogenesis of AD. Therefore, this review aims to summarize the latest progress in the field of BDNF and its biological roles in AD pathogenesis. We will discuss the interaction between BDNF and amyloid beta (Aβ) peptide, the effect of BDNF on synaptic repair in AD, and the association between BDNF polymorphism and AD risk. The most important is, enlightening the detailed biological ability and complicated mechanisms of action of BDNF in the context of AD would provide a future BDNF-related remedy for AD, such as increment in the production or release of endogenous BDNF by some drugs or BDNF mimics.
authors.affiliation: Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, China.|Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China.
authors.forename: Jing-Hui
authors.initials: JH
authors.lastname: Song
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. yu-jintai@163.com.
authors.forename: Jin-Tai
authors.initials: JT
authors.lastname: Yu
authors.affiliation: Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao, China. dr.tanlan@163.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Tan
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D001923:Brain Chemistry; D019208:Brain-Derived Neurotrophic Factor / Q000819:agonists / Q000235:genetics / Q000502:physiology*; D031204:Caloric Restriction; D004195:Disease Models, Animal; D005081:Exercise Therapy; D020022:Genetic Predisposition to Disease; D006624:Hippocampus / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D015994:Incidence; D007249:Inflammation; D051379:Mice; D058990:Molecular Targeted Therapy; D058953:Neural Stem Cells / Q000637:transplantation; D055495:Neurogenesis / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D010766:Phosphorylation; D008517:Phytotherapy; D020641:Polymorphism, Single Nucleotide; D011499:Protein Processing, Post-Translational; D020813:Receptor, trkB / Q000187:drug effects / Q000502:physiology; D012306:Risk; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D019208:Brain-Derived Neurotrophic Factor; C054369:MAPT protein, human; D018697:Nootropic Agents; D016875:tau Proteins; C579455:BDNF protein, human; D020813:Receptor, trkB
keywords: Alzheimer’s disease; Brain-derived neurotrophic factor; Pathogenesis; Polymorphism; Risk; Therapy