title: [Effects of dipeptidyl peptidase-4 on the hematopoiesis and transplantation].
abstract: Dipeptidyl peptidase-4 (DPP-4) is a protease that cleaves the peptides with alanine, praline, or other selective amino acids at the N-terminal penultimate position. The substrates of DPP-4 include many chemokines, colony-stimulating factors, and interleukins. Recent research has shown that DPP-4 can affect the hematopoietic stem and progenitor cells and transplantation by truncating the granulocyte colony stimulating factor. However, its regulatory effect on DPP-4 and most peptides truncation are still unknown. This review summarizes the recent advances in the DPP-4 research.
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Nuclear Medicine,Institute of Radiation Medicine,CAMS and PUMC,Tianjin 300192,China.
authors.forename: De-guan
authors.initials: DG
authors.lastname: Li
authors.affiliation: Tianjin Key Laboratory of Radiation Medicine and Nuclear Medicine,Institute of Radiation Medicine,CAMS and PUMC,Tianjin 300192,China.
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Meng
mesh_terms: D018819:Dipeptidyl Peptidase 4 / Q000502:physiology*; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans
chemical_list: C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4