title: Acute and late toxicity after three-dimensional conformal image-guided radiotherapy for localized prostate cancer.
abstract: We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years biochemical relapse-free survival was 90%. Acute and late gastrointestinal toxicities were low (3-year actuarial late toxicity of 11.2%). Acute genitourinary toxicity was relatively high, the 3-year actuarial genitourinary late toxicity was 12%. Conformal image-guided radiotherapy for localized prostate cancer leads to low rates of late toxicity with a high rate of tumor control.
authors.affiliation: Department of Diagnostic Imaging, Molecular Imaging, Interventional Radiology and Radiotherapy, Tor Vergata University General Hospital, 00133 Rome, Italy1.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Ingrosso
authors.forename: Alessandra
authors.initials: A
authors.lastname: Carosi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Ponti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Murgia
authors.forename: Daniela
authors.initials: D
authors.lastname: di Cristino
authors.forename: Rosaria
authors.initials: R
authors.lastname: Barbarino
authors.forename: Michaela
authors.initials: M
authors.lastname: Benassi
authors.forename: Luana
authors.initials: L
authors.lastname: Di Murro
authors.forename: Emilia
authors.initials: E
authors.lastname: Giudice
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Bove
authors.forename: Riccardo
authors.initials: R
authors.lastname: Santoni
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D054893:Cone-Beam Computed Tomography / Q000379:methods; D018572:Disease-Free Survival; D019583:Dose Fractionation, Radiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal / Q000009:adverse effects* / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000009:adverse effects* / Q000379:methods; D016896:Treatment Outcome
keywords: Bladder & prostate cancer; Imaging; Late effects of therapy