title: Intravitreal polypoidal choroidal vasculopathy in radiation retinopathy.
abstract: A 30-year-old woman diagnosed with choroidal melanoma and treated with plaque radiation and transpupillary thermotherapy 5 years earlier presented with recalcitrant proliferative radiation retinopathy despite multiple intravitreal anti-vascular endothelial growth factor injections. Swept-source and spectral-domain optical coherence tomography (OCT) demonstrated intravitreal polyps lying on the surface of atrophied chorioretinal tissue. Fluorescein angiography (FA) revealed leakage from these saccular choroidal neovasculopathic vessels adjacent to a large zone of poor choroidal perfusion. Intravitreal polypoidal choroidal vasculopathy may be associated with radiation retinopathy and is well-demonstrated with swept-source and spectral-domain OCT and FA.
authors.forename: Claudine E
authors.initials: CE
authors.lastname: Pang
authors.forename: K Bailey
authors.initials: KB
authors.lastname: Freund
mesh_terms: D000328:Adult; D001918:Brachytherapy; D002199:Capillary Permeability; D002830:Choroid Neoplasms / Q000532:radiotherapy; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D006979:Hyperthermia, Induced; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008545:Melanoma / Q000532:radiotherapy; D011127:Polyps / Q000175:diagnosis / Q000209:etiology*; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D012160:Retina / Q000473:pathology / Q000528:radiation effects*; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D041623:Tomography, Optical Coherence; D014822:Vitreous Body / Q000473:pathology
chemical_list: D007457:Iodine Radioisotopes