title: Mean platelet volume and platelet counts in type 2 diabetes: mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria.
abstract: BACKGROUND
  The Mean platelet volume and platelet counts are indicators of thrombotic potentials, and risk factors for microvascular complications in diabetics. This study aimed to establish variations in platelet counts and mean platelet volume in type 2 diabetic patients on treatment and non-diabetic controls.
  
  
  METHODS
  This was an unmatched case-control study involving 200 participants consisting of 100 diabetics and 100 non-diabetic controls. Four and half milliliters of blood was collected from diabetics and non diabetic controls into EDTA anticoagulant tubes. Full blood count was performed using the Sysmex KN-21N, (manufactured by Sysmex corporation Kobe, Japan) a three- part auto analyzer able to run 19 parameters per sample including platelet counts and mean platelet volume.
  
  
  RESULTS
  The mean fasting blood sugar for the diabetics was 147.85±72.54 mg/dl and the controls 95.20±30.10 mg/dl. The mean platelet count for the diabetics was 235.29±76.81*10(9)/L and controls, 211.32±66.44*10(9)/L. The mean platelet volume, for the diabetics was 8.69±0.67 fl and the controls, 8.91±0.80 fl. There was a statistically significant difference in platelet counts of diabetics and healthy controls p =0.038 while none existed between the mean platelet volume in diabetics and healthy controls p=0.593.
  
  
  CONCLUSIONS
  This study revealed a higher mean platelet count for diabetics on treatment than for non diabetic controls while mean platelet volume was lower in cases than controls. However, both parameters in diabetics on treatment were within the normal reference range for healthy individuals.
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Akinbami
authors.initials: A
authors.lastname: Akinsegun
authors.affiliation: Department of Medicine, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Dada
authors.initials: D
authors.lastname: Akinola Olusola
authors.affiliation: Department of Haematology, Ben Carson School of Medicine, Babcock University, Ilisan-Remo, Ogun State, Nigeria.
authors.forename: John-Olabode
authors.initials: JO
authors.lastname: Sarah
authors.affiliation: Department of Medicine, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Oshinaike
authors.initials: O
authors.lastname: Olajumoke
authors.affiliation: Department of Haematology, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idiaraba, Nigeria.
authors.forename: Adediran
authors.initials: A
authors.lastname: Adewumi
authors.affiliation: Oak Hospitals, Ikorodu, Lagos, Nigeria.
authors.forename: Odesanya
authors.initials: O
authors.lastname: Majeed
authors.affiliation: Department of Medicine, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Ogbera
authors.initials: O
authors.lastname: Anthonia
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Uche
authors.initials: U
authors.lastname: Ebele
authors.affiliation: Department of Medicine, University of PortHarcourt, River State, Nigeria.
authors.forename: Okunoye
authors.initials: O
authors.lastname: Olaitan
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University, College of Medicine, Ikeja, Nigeria.
authors.forename: Arogundade
authors.initials: A
authors.lastname: Olanrewaju
authors.affiliation: Department of Haematology and Blood Transfusion, Lagos State University, Teaching Hospital, Ikeja, Nigeria.
authors.forename: Aile
authors.initials: A
authors.lastname: Kingsley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D009549:Nigeria; D010976:Platelet Count; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: Controls; Mean platelet volume; Type 2 diabetics on treatment; platelet count