title: [Application of immunomodulators in the treatment of mandibular fractures in elderly patients with incomplete secondary adentia].
abstract: The aim of the work was to study the experience of using complex pharmacotherapy in the treatment of mandibular fractures in elderly patients with incomplete secondary periodontitis, which were divided into two groups. In the first group, patients (n = 46; average age 69.0 ± 3.6) were treated using the authors' original device combined with application of antimicrobial MetrogilDenta gel onto gums two times a day during ten days. Patients in the second group (n = 52; average age 61.0 ± 3.1) were treated with the same device combined with (i) application of MetrogilDenta antimicrobial gel onto gums two times a day during ten days, (ii) application of 1.5 ml of Cycloferon 5% liniment by cotton pellet for 20 min during the same 10 days (30 minutes after the antimicrobial gel), and (iii) intramuscular injections of 6 mg of synthetic immunomodulator Polyoxidonium once a day for 3 days, then once every two days (for a total of 17 days). It is established that the use of the combination of interferon inducers of immunomodulator group--Cycloferon in the form of liniment and synthetic immunomodulator Polyoksidonium together with MetrogilDenta antimicrobial gel--led to the most pronounced regression of inflammatory and destructive processes in periodontal tissues (in 7.1%, đ = 0.05), optimized the state of local immunity of the oral cavity, and normalized microflora in periodontal pockets in elderly patients with incomplete secondary adentia.
authors.forename: A V
authors.initials: AV
authors.lastname: Abramov
authors.forename: S A
authors.initials: SA
authors.lastname: Parfenov
authors.forename: V G
authors.initials: VG
authors.lastname: Belov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Parfenov
mesh_terms: D000166:Acridines / Q000627:therapeutic use*; D000287:Administration, Topical; D000368:Aged; D004334:Drug Administration Schedule; D005260:Female; D005782:Gels; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D007369:Interferon Inducers / Q000627:therapeutic use*; D008297:Male; D008337:Mandibular Fractures / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D010518:Periodontitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D010879:Piperazines / Q000627:therapeutic use*; D011108:Polymers / Q000627:therapeutic use*; D016388:Tooth Loss / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000166:Acridines; D005782:Gels; D007155:Immunologic Factors; D007369:Interferon Inducers; D010879:Piperazines; D011108:Polymers; C540909:azoximer bromide; C026430:10-carboxymethyl-9-acridanone