title: Facile preparation of a pH-sensitive nano-magnetic targeted system to deliver doxorubicin to tumor tissues.
abstract: We have developed a drug-loaded, pH-sensitive, nano-magnetic targeted system (DPNTS) for delivering doxorubicin (DOX) to tumor tissues through a facile route. Iron oxide (Fe3O4) nanoparticles were used as magnetically-responsive carriers, polyethyleneglycol (PEG) as the surface-modifying agent, and polyethyleneimine (PEI) as the drug-loading site whose primary amine reacts with the 13-carbonyl of DOX. The prepared DPNTS was within 20 nm and had good stability in dispersion and superparamagnetic properties. DOX was grafted to PEG/PEI@Fe3O4 at up to 85%. During in vitro release studies, nearly 81% DOX was released from DPNTS within 72 h at pH 4.5, compared with only 28% at pH 7.4.
authors.affiliation: National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing, 210094, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Jiang
authors.forename: Yueqing
authors.initials: Y
authors.lastname: Shen
authors.forename: Menglu
authors.initials: M
authors.lastname: Pu
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D004317:Doxorubicin / Q000493:pharmacokinetics*; D004337:Drug Carriers / Q000302:isolation & purification*; D005290:Ferric Compounds / Q000302:isolation & purification*; D006863:Hydrogen-Ion Concentration; D060328:Magnetic Phenomena; D049329:Nanostructures
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D005290:Ferric Compounds; C000499:ferric oxide; D004317:Doxorubicin