title: Targeting RANKL in the management of bone loss in patient with breast cancer.
abstract: The receptor activator of nuclear factor-kappaB ligand (RANKL), its signaling receptor RANK, and its natural decoy receptor OPG are members of the tumour necrosis factor (TNF) and TNF receptor superfamily and are best known for their essential role in controlling osteoclastogenesis. RANKL in bone has also been shown to serve as a chemoattractant for cancer cells, thu explaining the tropism of certain cancers such as breast and prostate cancer to preferentially metastasize to bone. Here, we will discuss the important role of RANKL and its possible role in the management of bone loss in patients with breast cancer.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Nicolin
authors.forename: Roberto
authors.initials: R
authors.lastname: Valentini
mesh_terms: D001862:Bone Resorption / Q000473:pathology* / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology*; D015195:Drug Design; D005260:Female; D006801:Humans; D053244:Osteoprotegerin / Q000502:physiology; D053245:RANK Ligand / Q000502:physiology*; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000502:physiology
chemical_list: D053244:Osteoprotegerin; D053245:RANK Ligand; D053246:Receptor Activator of Nuclear Factor-kappa B; C505686:TNFRSF11A protein, human; C506030:TNFRSF11B protein, human; C505688:TNFSF11 protein, human