title: [Progress in the diagnosis and treatment of cardiac amyloidosis].
abstract: The heart is an organ often occupied by various forms of amyloidosis; cardiomyopathies are the leading cause of mortality in patients with amyloidosis. Cardiac amyloidosis is often diagnosed late because of nonspecific symptoms and missed early signs in the imaging routine. A method for treating cardiac amyloidosis depends on the type of amyloid protein. In the treatment of amyloidosis associated with immunoglobulins systemic chemotherapy is used without transplant or stem cell transplantation and in the treatment of familial transthyretin amyloidosis liver transplantation is used. There are still clinical studies on the use of siRNA for the treatment of cardiomyopathy associated with transthy retin amyloidosis, and on the use of amyloid protein stabilizers. The prognosis depends on the type of amyloid protein; worse results observed in the case of light chain amyloidosis. Care support is the cornerstone of treatment; it is expected that advances in cardiac imaging and proteomics positive impact on our ability to diagnosis, prognosis and treatment outcomes of amyloidosis of the heart.
authors.forename: Artur
authors.initials: A
authors.lastname: Jurczyszyn
authors.forename: Anna
authors.initials: A
authors.lastname: Engel
authors.forename: Marek
authors.initials: M
authors.lastname: Rajzer
authors.forename: Jacek
authors.initials: J
authors.lastname: Czepiel
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Mazurs
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000628:therapy*; D009202:Cardiomyopathies / Q000175:diagnosis* / Q000628:therapy*; D057210:Delayed Diagnosis; D006801:Humans; D016031:Liver Transplantation; D011228:Prealbumin / Q000627:therapeutic use; D011379:Prognosis; D034741:RNA, Small Interfering / Q000627:therapeutic use; D033581:Stem Cell Transplantation; D016896:Treatment Outcome
chemical_list: D011228:Prealbumin; D034741:RNA, Small Interfering