title: Elevated levels of serum sICAM-1 in asphyxiated low birth weight newborns.
abstract: Perinatal hypoxia results in neuronal and endothelial cell damage. The main purpose of this study was to investigate the correlation of soluble intercellular adhesion molecule 1 (sICAM-1) expression and peripheral blood changes in perinatal asphyxia with neuronal injury markers in low birth weight (LBW) neonates. We compared the concentrations of serum sICAM-1, neuron-specific enolase (NSE) and antibodies specific for NR2 glutamate receptors in 29 asphyxiated and 20 control infants using standard enzyme immunoassay procedures. The mean total concentrations of sICAM-1 and neuron-specific proteins (NSE and NR2-specific antibodies) were higher in the asphyxiated infants than in the control infants. The serum sICAM-1 concentrations significantly correlated with Apgar scoring and with the pH and lactate data from capillary or arterial cord blood. No significant correlation between serum concentrations of neuron specific proteins and blood changes of asphyxia was found. Therefore, endothelial sICAM-1 expression levels might be accepted as an indicator of the severity of perinatal asphyxia in LBW infants.
authors.affiliation: Department of Neonatology, Azerbaijan Medical University, Baku, Azerbaijan.
authors.forename: Saadat
authors.initials: S
authors.lastname: Huseynova
authors.affiliation: Department of Neonatology, Azerbaijan Medical University, Baku, Azerbaijan.
authors.forename: Nushaba
authors.initials: N
authors.lastname: Panakhova
authors.affiliation: Sh. Alasgarova Maternity Hospital, Baku, Azerbaijan.
authors.forename: Pusta
authors.initials: P
authors.lastname: Orujova
authors.affiliation: K. Farajova Pediatry Institute, Baku, Azerbaijan.
authors.forename: Safikhan
authors.initials: S
authors.lastname: Hasanov
authors.affiliation: Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan.
authors.forename: Mehman
authors.initials: M
authors.lastname: Guliyev
authors.affiliation: Department of Biochemistry, Azerbaijan Medical University, Baku, Azerbaijan.
authors.forename: Agil
authors.initials: A
authors.lastname: Orujov
mesh_terms: D000906:Antibodies / Q000097:blood / Q000276:immunology; D001238:Asphyxia Neonatorum / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000097:blood; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
chemical_list: D000906:Antibodies; D015415:Biomarkers; C120997:NR2A NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate; D018799:Intercellular Adhesion Molecule-1; D010751:Phosphopyruvate Hydratase