title: The rabbit blood shunt subarachnoid haemorrhage model.
abstract: The recently introduced rabbit blood shunt subarachnoid haemorrhage model is based on the two standard procedures of subclavian artery cannulation and transcutaneous cisterna magna puncture. An extracorporeal shunt placed in between the arterial system and the subarachnoid space allows examiner-independent SAH in a closed cranium. Despite its straightforwardness, it is worth examining some specific features and characteristics of the model. We outline technical considerations to successfully perform the model with minimal mortality and morbidity. In addition, we discuss outcome measures, advantages and limitations, and the applicability of the model for the study of early brain injury and delayed cerebral vasospasm after SAH.
authors.affiliation: Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland, serge.marbacher@ksa.ch.
authors.forename: Serge
authors.initials: S
authors.lastname: Marbacher
authors.forename: Ali Reza
authors.initials: AR
authors.lastname: Fathi
authors.forename: Carl
authors.initials: C
authors.lastname: Muroi
authors.forename: Daniel
authors.initials: D
authors.lastname: Coluccia
authors.forename: Lukas
authors.initials: L
authors.lastname: Andereggen
authors.forename: Volker
authors.initials: V
authors.lastname: Neuschmelting
authors.forename: Hans Rudolf
authors.initials: HR
authors.lastname: Widmer
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Jakob
authors.forename: Javier
authors.initials: J
authors.lastname: Fandino
mesh_terms: D000818:Animals; D002946:Cisterna Magna / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004195:Disease Models, Animal; D011817:Rabbits; D011859:Radiography; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013346:Subarachnoid Space / Q000000981:diagnostic imaging / Q000503:physiopathology; D013348:Subclavian Artery / Q000000981:diagnostic imaging / Q000503:physiopathology; D020301:Vasospasm, Intracranial / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*