title: Varying definitions for periprocedural myocardial infarction alter event rates and prognostic implications.
abstract: BACKGROUND
  Periprocedural myocardial infarction (PMI) has had several definitions in the last decade, including the Society for Cardiovascular Angiography and Interventions (SCAI) definition, that requires marked biomarker elevations congruent with surgical PMI criteria.
  
  
  RESULTS
  The aim of this study was to examine the definition-based frequencies of PMI and whether they influenced the reported association between PMI and increased rates of late death/ myocardial infarction (MI). We studied 742 patients; 492 (66%) had normal troponin T (TnT) levels and 250 (34%) had elevated, but stable or falling, TnT levels. PMI, using the 2007 and the 2012 universal definition, occurred in 172 (23.2%) and in 99 (13.3%) patients, respectively, whereas 19 (2.6%) met the SCAI PMI definition (P<0.0001). Among patients with PMI using the 2012 definition, occlusion of a side branch ≤1 mm occurred in 48 patients (48.5%) and was the most common angiographic finding for PMI. The rates of death/MI at 2 years in patients with, compared to those without, PMI was 14.7% versus 10.1% (P=0.087) based on the 2007 definition, 16.9% versus 10.3% (P=0.059) based on the 2012 definition, and 29.4% versus 10.7% (P=0.015) based on the SCAI definition.
  
  
  CONCLUSIONS
  In this study, PMI, according to the SCAI definition, was associated with more-frequent late death/MI, with ≈20% of all patients, who had PMI using the 2007 universal MI definition, not having SCAI-defined PMI. Categorizing these latter patients as SCAI-defined no PMI did not alter the rate of death/MI among no-PMI patients.
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Hanan
authors.initials: H
authors.lastname: Idris
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Sidney
authors.initials: S
authors.lastname: Lo
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Shugman
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Yousef
authors.initials: Y
authors.lastname: Saad
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Hopkins
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Christian
authors.initials: C
authors.lastname: Mussap
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Dominic
authors.initials: D
authors.lastname: Leung
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Liza
authors.initials: L
authors.lastname: Thomas
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: Craig P
authors.initials: CP
authors.lastname: Juergens
authors.affiliation: Cardiology Department, Liverpool Hospital and South Western Sydney Clinical School, The University of New South Wales, Sydney, NSW, Australia (H.I., S.L., I.M.S., Y.S., A.P.H., C.M., D.L., L.T., C.P.J., J.K.F.).
authors.forename: John K
authors.initials: JK
authors.lastname: French
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003327:Coronary Disease / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D052279:Creatine Kinase, MB Form / Q000097:blood; D016208:Databases, Factual; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000145:classification / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy*; D009517:New South Wales; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects* / Q000401:mortality; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D009626:Terminology as Topic; D013997:Time Factors; D016896:Treatment Outcome; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T; D052279:Creatine Kinase, MB Form
keywords: percutaneous coronary intervention; periprocedural myocardial infarction; reinfarction; troponin T