title: The sarcoplasmic reticulum and the evolution of the vertebrate heart.
abstract: The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence suggests differences in SR function across species may have an underlying structural basis. Here, we discuss how SR recruitment relates to the structural organization of the cardiomyocyte to provide new insight into the evolution of cardiac design and function in vertebrates.
authors.affiliation: Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom; and holly.shiels@manchester.ac.uk.
authors.forename: Holly A
authors.initials: HA
authors.lastname: Shiels
authors.affiliation: Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.
authors.forename: Gina L J
authors.initials: GL
authors.lastname: Galli
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001833:Body Temperature Regulation; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism*; D056966:Excitation Contraction Coupling; D006801:Humans; D009200:Myocardial Contraction; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000648:ultrastructure; D012519:Sarcoplasmic Reticulum / Q000378:metabolism* / Q000648:ultrastructure; D013045:Species Specificity
chemical_list: D015220:Calcium Channels; D002118:Calcium