title: Improved release and metabolism of flavonoids by steered fermentation processes: a review.
abstract: This paper provides an overview on steered fermentation processes to release phenolic compounds from plant-based matrices, as well as on their potential application to convert phenolic compounds into unique metabolites. The ability of fermentation to improve the yield and to change the profile of phenolic compounds is mainly due to the release of bound phenolic compounds, as a consequence of the degradation of the cell wall structure by microbial enzymes produced during fermentation. Moreover, the microbial metabolism of phenolic compounds results in a large array of new metabolites through different bioconversion pathways such as glycosylation, deglycosylation, ring cleavage, methylation, glucuronidation and sulfate conjugation, depending on the microbial strains and substrates used. A whole range of metabolites is produced, however metabolic pathways related to the formation and bioactivities, and often quantification of the metabolites are highly underinvestigated. This strategy could have potential to produce extracts with a high-added value from plant-based matrices.
authors.affiliation: Department of Industrial Biological Sciences, Faculty of Bioscience Engineering, Ghent University-Campus Kortrijk, Graaf Karel de Goedelaan 5, 8500 Kortrijk, Belgium. guy.smagghe@ugent.be.
authors.forename: Nguyen Thai
authors.initials: NT
authors.lastname: Huynh
authors.affiliation: Department of Food Safety and Food Quality, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium. john.vancamp@ugent.be.
authors.forename: John
authors.initials: J
authors.lastname: Van Camp
authors.affiliation: Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, 9000 Ghent, Belgium. guy.smagghe@ugent.be.
authors.forename: Guy
authors.initials: G
authors.lastname: Smagghe
authors.affiliation: Department of Industrial Biological Sciences, Faculty of Bioscience Engineering, Ghent University-Campus Kortrijk, Graaf Karel de Goedelaan 5, 8500 Kortrijk, Belgium. katleen.raes@ugent.be.
authors.forename: Katleen
authors.initials: K
authors.lastname: Raes
mesh_terms: D001711:Biotransformation; D005285:Fermentation; D005419:Flavonoids / Q000737:chemistry* / Q000378:metabolism*; D053858:Metabolic Networks and Pathways; D010944:Plants / Q000737:chemistry / Q000378:metabolism
chemical_list: D005419:Flavonoids