title: IRBIT promotes allosteric inhibition of ribonucleotide reductase.
abstract: IRBIT inhibits ribonucleotide reductase (RNR) by stabilizing dATP binding to the RNR activity site.
mesh_terms: D000494:Allosteric Regulation; D003838:Deoxyadenine Nucleotides / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: C470184:CLECL1 protein, human; D003838:Deoxyadenine Nucleotides; D037181:Lectins, C-Type; D008565:Membrane Proteins; D012264:Ribonucleotide Reductases; C026600:2'-deoxyadenosine triphosphate