title: Long-term follow-up of borderline ovarian tumors clinical outcome and prognostic factors.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the characteristics of borderline ovarian tumors (BOTs).
  
  
  METHODS
  Data of 151 patients with BOTs were retrospectively evaluated.
  
  
  RESULTS
  A total of 151 cases with BOTs were diagnosed. Histopathological evaluation identified 82.8% with serous, 10.6% with mucinous and 5.3% with mixed histology. Overall, 67.5% had International Federation of Gynecology and Obstetrics (FIGO) stage I, 10.6% FIGO stage II, 14.6% FIGO stage III and 4% FIGO stage IV. A total of 21.9% had peritoneal implants; of which 2.7% were invasive, 17.2% non-invasive and 2% both invasive and non-invasive. Microinvasion was observed in 5.3% and a micropapillary pattern in 12.6%. A total of 12.6% of patients presented second neoplasms. During a median follow-up period of 86 (range=0.1-432) months, there were relapses in 16.8%, of which 52.6% had invasive implants. Overall, 6.2% died of their disease, 28.5% with invasive implants. The median time-to-progression was 48 (range=8-120) months.
  
  
  CONCLUSIONS
  Patients with BOTs have an excellent prognosis. Long-term follow-up is recommended, since recurrence occurs.
authors.affiliation: Department of Obstetrics, Charité, Virchow Campus Clinic University-Hospital, Berlin, Germany.
authors.forename: Anastasia
authors.initials: A
authors.lastname: Lazarou
authors.affiliation: European Competence Center for Ovarian Cancer, Department of Gynecology, Charité, Virchow Campus Clinic University-Hospital, Berlin, Germany.
authors.forename: Christina
authors.initials: C
authors.lastname: Fotopoulou
authors.affiliation: Outpatient Practice of Gynecological Oncology, Berlin, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Coumbos
authors.affiliation: European Competence Center for Ovarian Cancer, Department of Gynecology, Charité, Virchow Campus Clinic University-Hospital, Berlin, Germany jalid.sehouli@charite.de.
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.affiliation: Department of Gynecology, Charité, Mitte Campus Clinic University-Hospital, Berlin, Germany.
authors.forename: Jekaterina
authors.initials: J
authors.lastname: Vasiljeva
authors.affiliation: European Competence Center for Ovarian Cancer, Department of Gynecology, Charité, Virchow Campus Clinic University-Hospital, Berlin, Germany.
authors.forename: Ioana
authors.initials: I
authors.lastname: Braicu
authors.affiliation: Department of Geoinformatics, Freie University, Berlin, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Burger
authors.affiliation: Outpatient Practice of Gynecological Oncology, Berlin, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kuehn
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D018284:Cystadenocarcinoma, Serous / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult
keywords: Borderline ovarian tumor; implants; prognosis; relapse; surgery