title: A facile access to 4-substituted-2-naphthols via a tandem Friedel-Crafts reaction: a β-chlorovinyl ketone pathway.
abstract: A one-pot synthesis of 2-naphthol derivatives is accomplished using a tandem Friedel-Crafts reaction sequence. The developed methodology allows for a concomitant construction of up to three C-C bonds between readily available alkynes and phenylacetyl chloride derivatives by an intermolecular Friedel-Crafts acylation of alkynes followed by an intramolecular Friedel-Crafts alkylation of β-chlorovinyl ketone intermediates.
authors.affiliation: College of Pharmacy, Chung-Ang University , 84 Heukseok-ro, Dongjak, Seoul 156-756, Republic of Korea.
authors.forename: Hun Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Kyungsoo
authors.initials: K
authors.lastname: Oh