title: Clinical study of customized aspherical intraocular lens implants.
abstract: OBJECTIVE
  To compare if there is an improvement in visual functions with age-related cataracts between patients receiving a aspherical intraocular lens (IOL) based on corneal wavefront aberration and patients randomly assigned lenses.
  
  
  METHODS
  A total of 124 eyes of 124 patients with age-related cataracts were placed in experimental group and a group receiving randomly assigned (RA) lenses. The experimental group was undergone Pentacam corneal spherical aberration measurement before surgery; the targeted range for residual total spherical aberration after surgery was set to 0-0.3 µm. Patients with a corneal spherical aberration <0.3 µm were implanted with a zero-spherical aberration advanced optics (AO) aspherical IOL and patients with an aberration ≥0.3 µm received a Tecnis Z9003 aspherical lens in experimental group. RA patients were randomly implanted with an AO lens or a Tecnis Z9003 lens. Three months after surgery total spherical aberration, photopic/mesopic contrast sensitivities, photopic/mesopic with glare contrast sensitivities, and logMAR vision were measured.
  
  
  RESULTS
  Statistical analysis on logMAR vision showed no significant difference between two groups (P=0.413). The post-surgical total spherical aberration was 0.126±0.097 µm and 0.152±0.151 µm in the experimental and RA groups, respectively (P=0.12). The mesopic contrast sensitivities at spatial frequencies of 6, 12 and 18 c/d in the experimental group were significantly higher than of the RA group (P=0.00; P=0.04; P=0.02). The mesopic with glare contrast sensitivity in the experimental group at a spatial frequency of 18 c/d was also significantly higher vs the RA group (P=0.01).
  
  
  CONCLUSIONS
  Pre-surgical corneal spherical aberration measurement in cataract patients followed by customized selection of aspherical IOL implants improved mesopic contrast sensitivities at high spatial frequencies, and thus is a superior strategy compared to the random selection of aspherical IOL implants.
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Lie-Xi
authors.initials: LX
authors.lastname: Jia
authors.affiliation: Department of Ophthalmology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Zhao-Hui
authors.initials: ZH
authors.lastname: Li
keywords: cataract extraction; corneal wavefront aberration; intraocular lens; mesopic vision; night vision