title: Fecal calprotectin and ulcerative colitis endoscopic activity index as indicators of mucosal healing in ulcerative colitis.
abstract: Ulcerative colitis (UC) is a chronic, idiopathic, inflammatory large bowel disease with recurrent variable periods of exacerbation. The aim of the current study is to evaluate the correlation of UCEIS with fecal calprotectin (FC) level to assess disease activity in UC patients in order to determine whether FC can prognosticate clinical outcome and disease activity of UC instead of colonoscopic evaluation. Our endoscopic investigations revealed the extension of UC as the following: proctitis (11.6%), procto-sigmoiditis (18.5%), left-sided colitis (15.8%), extensive colitis (11.7%), and normal endoscopy (42.4%). Conclusively, we suggest that FC can be used as a reliable tool to evaluate disease activity in ulcerative colitis patients. Moreover, our findings indicate a significant correlation between FC level and mucosal healing.
authors.affiliation: Inflammatory Diseases of Upper Gastrointestinal Tract Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Amir Mazandarani Street, 48166-33131, Sari, Iran.
authors.forename: Tarang
authors.initials: T
authors.lastname: Taghvaei
authors.forename: Iradj
authors.initials: I
authors.lastname: Maleki
authors.forename: Farshad
authors.initials: F
authors.lastname: Nagshvar
authors.forename: Hafez
authors.initials: H
authors.lastname: Fakheri
authors.forename: Vahid
authors.initials: V
authors.lastname: Hosseini
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Valizadeh
authors.forename: Hassan
authors.initials: H
authors.lastname: Neishaboori
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D003093:Colitis, Ulcerative / Q000473:pathology*; D016099:Endoscopy, Gastrointestinal; D005243:Feces / Q000737:chemistry*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D008297:Male; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex