title: Vedolizumab for ulcerative colitis and Crohn's disease: results and implications of GEMINI studies.
abstract: Vedolizumab (VDZ) is a selective antibody against α4β7-integrin, which targets leukocyte trafficking in the gastrointestinal tract. The GEMINI studies are Phase 3, randomized, placebo-controlled trials to assess the efficacy of VDZ in induction and maintenance of moderately to severely active ulcerative colitis (GEMINI 1) and Crohn's disease (GEMINI 2). Included in these studies are patients who have failed TNF-α antagonist therapy. GEMINI 1 showed that VDZ is an effective agent in induction and maintenance of ulcerative colitis. GEMINI 2 met one of two primary end points in the induction phase showing that VDZ is more likely to induce clinical remission compared with placebo. VDZ is an effective agent in the maintenance of Crohn's disease. These studies pave the way to a new class of medications for treatment of inflammatory bowel disease.
authors.affiliation: Division of Gastroenterology, 770-1190 Hornby Street, Vancouver, BC, V6Z 2K5, Canada.
authors.forename: Mindy Cw
authors.initials: MC
authors.lastname: Lam
authors.forename: Brian
authors.initials: B
authors.lastname: Bressler
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D003424:Crohn Disease / Q000188:drug therapy*; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D016023:Integrins / Q000037:antagonists & inhibitors / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D005765:Gastrointestinal Agents; D016023:Integrins; D014409:Tumor Necrosis Factor-alpha; C071777:integrin alpha4beta7; C543529:vedolizumab
keywords: CD; Crohn's disease; GEMINI; UC; VDZ; ulcerative colitis; vedolizumab; α4β7-integrin