title: Seizure freedom after lamotrigine rash: a peculiar phenomenon in epilepsy.
abstract: A 57-year-old right-handed woman with a history of left frontal lobe stroke had experienced episodes of language-expression difficulty followed by paraphasia lasting for approximately 30 seconds two years earlier. She was diagnosed with left frontal lobe epilepsy, and a lamotrigine regimen was initiated. This treatment had to be stopped five weeks after initiation because she developed a rash, and her drug lymphocyte stimulation test result was positive. Interestingly, she has since remained seizure free without requiring any antiepileptic medications. This adult case with a peculiar clinical course provides support for the hypothesis of immunomodulation process involvement in epilepsy, a phenomenon that was previously mainly seen in pediatric patients.
authors.affiliation: Department of Epileptology, Tohoku University School of Medicine, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kakisaka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Jin
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kato
authors.forename: Masaki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Nakasato
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D017034:Epilepsy, Frontal Lobe / Q000188:drug therapy* / Q000209:etiology; D005076:Exanthema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008875:Middle Aged; D020521:Stroke / Q000150:complications; D014227:Triazines / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D000077213:Lamotrigine