title: Islet cell transplantation in Australia: screening, remote transplantation, and incretin hormone secretion in insulin independent patients.
abstract: Islet cell transplantation has emerged as a treatment modality for type 1 diabetes in the last 15 years due to the Edmonton protocol leading to consistent and sustained exogenous insulin independence post-transplantation. In recent years, consortia that involve both local and remote islet cell centers have been established, with local centers responsible for processing and shipping of islet cells, and remote centers only transplanting them. There are, however, few data on patient outcomes at remote centers. A tendency for high fasting glucose despite insulin independence was noted by us and others with an unknown mechanism. This review provides a brief history of islet cell transplantation, and focuses on the South Australian remote center experience: the challenges, screening criteria, and the impact on incretin hormone secretion of insulin independent transplant patients.
authors.affiliation: Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: C S
authors.initials: CS
authors.lastname: Marathe
authors.affiliation: Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: C J
authors.initials: CJ
authors.lastname: Drogemuller
authors.affiliation: Department of Medicine, The Queen Elizabeth Hospital, Adelaide, Australia.
authors.forename: J A
authors.initials: JA
authors.lastname: Marathe
authors.affiliation: Department of Endocrinology and Diabetes, St Vincent's Hospital and University of Melbourne, Melbourne, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Loudavaris
authors.affiliation: National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Sydney, Australia.
authors.forename: W J
authors.initials: WJ
authors.lastname: Hawthorne
authors.affiliation: National Pancreas Transplant Unit, University of Sydney at Westmead Hospital, Sydney, Australia.
authors.forename: P J
authors.initials: PJ
authors.lastname: O'Connell
authors.affiliation: Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: T
authors.initials: T
authors.lastname: Radford
authors.affiliation: Department of Endocrinology and Diabetes, St Vincent's Hospital and University of Melbourne, Melbourne, Australia.
authors.forename: T W H
authors.initials: TW
authors.lastname: Kay
authors.affiliation: Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.affiliation: Central Northern Adelaide Renal and Transplantation Service, and University of Adelaide at Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: P T
authors.initials: PT
authors.lastname: Coates
authors.affiliation: Endocrine & Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia.
authors.forename: D J
authors.initials: DJ
authors.lastname: Torpy
mesh_terms: D001315:Australia; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D006297:Health Services Accessibility; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D007328:Insulin / Q000627:therapeutic use*; D016381:Islets of Langerhans Transplantation; D008403:Mass Screening
chemical_list: D054795:Incretins; D007328:Insulin