title: [Updates on Lifestyle-Related Diseases and Bone Metabolism. Genomic aspects of metabolic syndrome and osteoporosis].
abstract: A number of candidate gene approach and genome-wide association studies have found novel single-nucleotide polymorphisms (SNPs) associated with complex diseases/traits, including metabolic diseases and osteoporosis. This review highlights common aspects of genetic susceptibility to metabolic diseases and osteoporosis. Some of these SNPs were mapped as close to or within Wnt-β-catenin signaling genes. Future studies may uncover the direct association between the pathogenesis of metabolic diseases and osteoporosis.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Urano
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D055106:Genome-Wide Association Study; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000235:genetics* / Q000378:metabolism*; D010024:Osteoporosis / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide