title: Diversity-oriented synthesis of intensively blue emissive 3-hydroxyisoquinolines by sequential Ugi four-component reaction/reductive Heck cyclization.
abstract: A convergent approach to highly functionalized 3-hydroxyisoquinolines is reported. The key steps are an Ugi multicomponent reaction and a subsequent intramolecular reductive Heck reaction; these can also be performed as a one-pot procedure. The structures display very interesting properties as blue-fluorescence emitters. Photophysical studies on the absorption and static fluorescence indicate that the substitution pattern on the pyridyl part influences the optical properties only to a minor extent, unless the amide substituent becomes sterically demanding and leads to significant nonradiative deactivation. The donor substitution on the benzo core considerably enhances the fluorescence quantum yields and trimethoxy substitution causes a pronounced redshift of the emission bands. Protonation of the isoquinolyl nitrogen atom causes efficient static quenching of the fluorescence.
authors.affiliation: Dipartimento di Chimica e Chimica Industriale, University of Genova, Via Dodecaneso 31, 16146 Genova (Italy).
authors.forename: Lisa
authors.initials: L
authors.lastname: Moni
authors.forename: Melanie
authors.initials: M
authors.lastname: Denissen
authors.forename: Gianluca
authors.initials: G
authors.lastname: Valentini
authors.forename: Thomas J J
authors.initials: TJ
authors.lastname: Müller
authors.forename: Renata
authors.initials: R
authors.lastname: Riva
mesh_terms: D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry*; D049449:Luminescence; D008958:Models, Molecular; D010084:Oxidation-Reduction
chemical_list: D007546:Isoquinolines
keywords: Heck reaction; fluorescence; isoquinolines; multicomponent reactions; photochromism