title: A validated mathematical model of tumor growth including tumor-host interaction, cell-mediated immune response and chemotherapy.
abstract: We consider a dynamical model of cancer growth including three interacting cell populations of tumor cells, healthy host cells and immune effector cells. The tumor-immune and the tumor-host interactions are characterized to reproduce experimental results. A thorough dynamical analysis of the model is carried out, showing its capability to explain theoretical and empirical knowledge about tumor development. A chemotherapy treatment reproducing different experiments is also introduced. We believe that this simple model can serve as a foundation for the development of more complicated and specific cancer models.
authors.affiliation: Nonlinear Dynamics, Chaos and Complex Systems Group, Departamento de Física, Universidad Rey Juan Carlos, Tulipán s/n, 28933, Móstoles, Madrid, Spain.
authors.forename: Alvaro G
authors.initials: AG
authors.lastname: López
authors.forename: Jesús M
authors.initials: JM
authors.lastname: Seoane
authors.forename: Miguel A F
authors.initials: MA
authors.lastname: Sanjuán
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007111:Immunity, Cellular; D055641:Mathematical Concepts; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents