title: Burden and cost of neurological diseases: a European North-South comparison.
abstract: OBJECTIVE
  To address the relationship between years lived with a disability (YLDs), prevalence and cost of neurological diseases, and to test whether there is a European North-South gradient for national health expenditure, disability, costs and prevalence of neurological diseases.
  
  
  METHODS
  Information on costs, prevalence and YLDs referred to 2010 were taken from the Study on the Cost of Disorders of the Brain and from the Global Burden of Disease study; data on health expenditure were taken from OECD reports. Selected conditions were as follows: brain tumours, stroke, dementia, Parkinson's disease, epilepsy, multiple sclerosis, migraine and tension-type headache; selected countries were from North (Denmark, Finland, Norway, Sweden) and South (Greece, Italy, Portugal, Spain) Europe. The association between the variables for each condition was tested using Spearman's correlation; Wilcoxon signed ranks test was used to test North-South Europe differences.
  
  
  RESULTS
  Correlations were largely non-significant (except for stroke). YLDs and cost were generally lower in South-European countries, and prevalence was lower in North-European countries, but no significant differences were found.
  
  
  CONCLUSIONS
  Health expenditure, YLDs, costs and prevalence of neurological conditions were generally not correlated across the eight countries. A clear North-South gradient was found for health expenditures, and partially for YLDs, costs and diseases' prevalence. We hypothesized that this is a consequence of the expansion of morbidity of neurological conditions connected to ageing, that health and welfare systems of selected countries were not prepared to face.
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Raggi
authors.affiliation: Neurology, Public Health and Disability Unit, Neurological Institute C. Besta IRCCS Foundation, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Leonardi
mesh_terms: D000375:Aging; D017281:Cost of Illness; D005060:Europe / Q000453:epidemiology; D005102:Health Expenditures; D006801:Humans; D015994:Incidence; D009422:Nervous System Diseases / Q000191:economics* / Q000453:epidemiology*
keywords: burden; cost of disorders; disability; europe; health expenditure; years lived with a disability