title: CA15.3 serum concentrations in older women with infiltrating ductal carcinomas of the breast.
abstract: Breast cancer is currently becoming a disease of the elderly. We have studied the relation between CA 15.3 serum concentrations and clinical-pathological parameters in 69 women with IDC aged over 70 years (76.3±4.2; range: 71-88; median 76). A group of 205 women with the same tumor but aged <70 years (62.8±4.0; range: 55-70; median 63) was also considered for comparison. Tumor size, axillary lymph node involvement, distant metastasis and histological grade were taken account. Serum CA 15.3 was determined by luminescence assay. CA 15.3 serum concentrations ranged between 6 and 85 U/mL (median 22.9 U/mL), and were higher only in patients with greater (qualitative and quantitative; p: 0.041) tumor size. Our results show that in women with IDCs, and aged over 70 years, serum CA 15.3 serum concentrations are associated exclusively with a greater tumor size, being these findings different to those described in women with the same subtype of tumor considered as a whole or with lower age.
authors.affiliation: Molecular Imaging Group, F. Medicine, University of Santiago Compostela, R/de San Francisco, s/n, Santiago de Compostela 15782, Spain.
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Ruibal
authors.affiliation: Molecular Imaging Group, F. Medicine, University of Santiago Compostela, R/de San Francisco, s/n, Santiago de Compostela 15782, Spain. pablo.aguiar.fernandez@sergas.es.
authors.forename: Pablo
authors.initials: P
authors.lastname: Aguiar
authors.affiliation: General Lab, H. Virgen Xunqueira, P/Pepe Sánchez, 7, Cee, A Coruña 15270, Spain. Maria.del.Carmen.Del.Rio.Garma@sergas.es.
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Del Río
authors.affiliation: Anatomía Humana Area, University of Vigo, Lagoas-Marcosende, s/n, Vigo 36310, Spain. mariaelena.padin.iruegas@sergas.es.
authors.forename: María Elena
authors.initials: ME
authors.lastname: Padín-Iruegas
authors.affiliation: Surgery Department, Hospital of Monte Naranco, Av Fernández Vega, 107, Oviedo 33012, Spain. joseignacio.arias@sespa.princast.es.
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Arias
authors.affiliation: Molecular Imaging Group, F. Medicine, University of Santiago Compostela, R/de San Francisco, s/n, Santiago de Compostela 15782, Spain. michel.herranz.carnero@sergas.es.
authors.forename: Michel
authors.initials: M
authors.lastname: Herranz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002272:Carcinoembryonic Antigen / Q000097:blood*; D044584:Carcinoma, Ductal / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008207:Lymphatic Metastasis; D018396:Mucin-1 / Q000097:blood*; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D018396:Mucin-1