title: A PRELIMINARY STUDY ON THE EFFECT OF MOTION CORRECTION ON HARDI RECONSTRUCTION.
abstract: Post-acquisition motion correction is widely performed in diffusion-weighted imaging (DWI) to guarantee voxel-wise correspondence between DWIs. Whereas this is primarily motivated to save as many scans as possible if corrupted by motion, users do not fully understand the consequences of different types of interpolation schemes on the final analysis. Nonetheless, interpolation might increase the partial volume effect while not preserving the volume of the diffusion profile, whereas excluding poor DWIs may affect the ability to resolve crossing fibers especially with small separation angles. In this paper, we investigate the effect of interpolating diffusion measurements as well as the elimination of bad directions on the reconstructed fiber orientation diffusion functions and on the estimated fiber orientations. We demonstrate such an effect on synthetic and real HARDI datasets. Our experiments demonstrate that the effect of interpolation is more significant with small fibers separation angles where the exclusion of motion-corrupted directions decreases the ability to resolve such crossing fibers.
authors.affiliation: Scientific Computing and Imaging Institute, Salt Lake City, UT, USA.
authors.forename: Shireen
authors.initials: S
authors.lastname: Elhabian
authors.affiliation: Scientific Computing and Imaging Institute, Salt Lake City, UT, USA.
authors.forename: Yaniv
authors.initials: Y
authors.lastname: Gur
authors.affiliation: Scientific Computing and Imaging Institute, Salt Lake City, UT, USA.
authors.forename: Clement
authors.initials: C
authors.lastname: Vachet
authors.affiliation: Dept. of Psychiatry, University of North Carolina, NC, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Piven
authors.affiliation: Dept. of Psychiatry, University of North Carolina, NC, USA. ; Dept. of Computer Science, University of North Carolina, NC, USA.
authors.forename: Martin
authors.initials: M
authors.lastname: Styner
authors.affiliation: Dept. of Neurology and Neurosurgery, Montral Neurological Institute, Montral, Quebec, Canada.
authors.forename: Ilana
authors.initials: I
authors.lastname: Leppert
authors.affiliation: Dept. of Neurology and Neurosurgery, Montral Neurological Institute, Montral, Quebec, Canada. ; Dept. of Radiology, University of Calgary, Calgary, Canada.
authors.forename: G Bruce
authors.initials: GB
authors.lastname: Pike
authors.affiliation: Scientific Computing and Imaging Institute, Salt Lake City, UT, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Gerig
keywords: Diffusion MRI; HARDI; interpolation; motion correction