title: Sneddon syndrome: rare disease or under diagnosed clinical entity? Review of the literature related to a clinical case.
abstract: Sneddon syndrome is defined by the association of livedo racemosa and recurrent cerebrovascular ischemic lesions. The annual incidence is 4/1,000,000. This syndrome particularly affects young women, some reports suggesting a family predisposition. It is a chronic, progressive, arterio-occlusive disease of unknown etiology that involves small and medium-sized arteries. It is usually associated with antiphospholipid antibodies. We report the case of a female patient with Sneddon syndrome with significant family history, personal history of stroke, epilepsy, migraine, cardiovascular involvement, three miscarriages, cognitive decline, noncompliant to therapy, in the absence of antiphospholipid antibodies. This paper aims to analyze the main characteristic features and management of Sneddon syndrome by conducting a literature review related to a clinical case.
authors.forename: Amalia
authors.initials: A
authors.lastname: Orac
authors.forename: Anca
authors.initials: A
authors.lastname: Artenie
authors.forename: Mihaela Paula
authors.initials: MP
authors.lastname: Toader
authors.forename: Raluca
authors.initials: R
authors.lastname: Harnagea
authors.forename: Diana
authors.initials: D
authors.lastname: Dinu-Mitrofan
authors.forename: Mirela
authors.initials: M
authors.lastname: Grigorovici
authors.forename: G
authors.initials: G
authors.lastname: Ungureanu
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis; D001706:Biopsy; D003937:Diagnosis, Differential; D004827:Epilepsy / Q000175:diagnosis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D054068:Livedo Reticularis / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008881:Migraine Disorders / Q000175:diagnosis; D010375:Pedigree; D011379:Prognosis; D035583:Rare Diseases; D012307:Risk Factors; D012867:Skin / Q000473:pathology*; D018860:Sneddon Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D020521:Stroke / Q000175:diagnosis; D016896:Treatment Outcome