title: THE INTAKE OF FIBER MESOCARP PASSIONFRUIT (PASSIFLORA EDULIS) LOWERS LEVELS OF TRIGLYCERIDE AND CHOLESTEROL DECREASING PRINCIPALLY INSULIN AND LEPTIN.
abstract: BACKGROUND
  Diabetes mellitus (DM) is a major risk factor for coronary artery disease, renal failure, retinopathy, and neuropathy. Over the last years, there has been an increasing demand in folk medicine for natural sources that could help in the treatment of chronic diseases, including diabetes. The rind of passion fruit (Passiflora edulis f. Flavicarpa) is traditionally used as a functional food due to its high concentration of soluble and insoluble fiber.
  
  
  OBJECTIVE
  The aim of this study was to determine the effect of high-fiber diet albedo of passion fruit on the metabolic and biochemical profile in diabetic rats induced by alloxan (2%).
  
  
  METHODS
  The passion fruit mesocarp fiber was dried in an oven with circulating air at 60°C and pulverized. We used 32 adult male rats, divided into 4 groups: Wistar group 1 control (GC), Wistar group 2, 15% fiber (GF15), Wistar group 3, 30% fiber (GF30), Wistar group 4, fiber disolved in water (GFH2O). The ratio of passion fruit was prepared according to the AIN 93M guidelines, varying only the source of dietary fiber. The corresponding diet for each group was offered to the animals for 60 days.
  
  
  RESULTS
  There was a statically significant decrease in plasma glucose for GFH2O, GF15%, and GF30% groups with 27.0%, 37.4%, and 40.2%, respectively.
  
  
  CONCLUSIONS
  The use of mesocarp fiber of passion fruit at concentrations of 15% and 30% are an important dietary supplement for the treatment of DM due to its potential hypoglycemic effect, and its ability to reduce triglycerides and VLDL-cholesterol levels with a principal reduction of insulin and leptin.
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: E M
authors.initials: EM
authors.lastname: Corrêa
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorin, 330 - Aparecida, Manaus-AM/Brazil,CEP: 69010-300.
authors.forename: L
authors.initials: L
authors.lastname: Medina
authors.affiliation: Biochemistry Department at Ponce School of Medicine and Health Sciences Ponce, Puerto Rico.
authors.forename: J
authors.initials: J
authors.lastname: Barros-Monteiro
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: N O
authors.initials: NO
authors.lastname: Valle
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Sales
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Magalães
authors.affiliation: Instituto Nacional de Pesquisas da Amazônia -Coordenação Sociedade Saúde Ambiente- Laboratório de Alimentos.
authors.forename: F C A
authors.initials: FC
authors.lastname: Souza
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: T B
authors.initials: TB
authors.lastname: Carvalho
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: J R
authors.initials: JR
authors.lastname: Lemos
authors.affiliation: Fundação de Hematologia e Hemoterapia do Estado do Amazonas (FEMOAM)- Nucleo de Estatística - Av. Constatino Nery.
authors.forename: E F
authors.initials: EF
authors.lastname: Lira
authors.affiliation: Faculdade de Ciências Farmacêuticas, Universidade Federal do Amazonas, Rua Alexandre Amorin, 330 - Aparecida, Manaus-AM/Brazil,CEP: 69010-300.
authors.forename: E S
authors.initials: ES
authors.lastname: Lima
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: D M L
authors.initials: DM
authors.lastname: Galeno
authors.affiliation: Public Health Program.
authors.forename: L
authors.initials: L
authors.lastname: Morales
authors.affiliation: Physiology and Pharmacology Department at Ponce School of Medicine and Health Sciences Ponce, Puerto Rico.
authors.forename: C
authors.initials: C
authors.lastname: Ortiz
authors.affiliation: Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Departamento de Química, Instituto de Ciências Exatasb Universidade Federal do Amazonas, Av. Gen. Rodrigo Octávio Jordão Ramos, 3000 - Coroado, Manaus -AM - Brazil.
authors.forename: R P
authors.initials: RP
authors.lastname: Carvalho
keywords: Diabetes; passion fruit fiber