title: Luteolin supplementation adjacent to aspirin treatment reduced dimethylhydrazine-induced experimental colon carcinogenesis in rats.
abstract: Previous studies have shown that aspirin is used in colon cancer treatment. However, long-term of Aspirin usage is limited to gastric and renal toxicity. Luteolin (LUT) has cancer prevention and anti-inflammatory effects. The present study was designed to investigate the effect of LUT supplementation and Aspirin treatment in dimethylhydrazine (DMH)-induced carcinogenesis in rats. DMH (20 mg/kg BW/week) treated rats received gavages with Aspirin (50 mg/kg BW/week) and LUT (0.2 mg/kg BW/day) for 15 weeks. DMH injections induce colon polyps and renal bleeding, significantly increasing carcinoembryonic antigen (CEA), cyclooxygenase-2 (COX-2), oxidative stress, and kidney function tests and reducing antioxidant markers. Either Aspirin or LUT gavages alone or combined produce a significant decrease in colon polyp number and size, significantly decreasing CEA, COX-2, and oxidative stress and increasing antioxidant markers. In conclusion, the supplementations of LUT adjacent to Aspirin in the treatment of DMH-induced carcinogenesis in rats reflect a better effect than the use of Aspirin alone.
authors.affiliation: Radiation Biology Department, National Centre for Radiation Research and Technology, Atomic Energy Authority, 3 Ahmed Elzomor street, Nasr City, Cairo, Egypt, Neamatosman@yahoo.com.
authors.forename: Neamt H A
authors.initials: NH
authors.lastname: Osman
authors.forename: Usama Z
authors.initials: UZ
authors.lastname: Said
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: El-Waseef
authors.forename: Esraa S A
authors.initials: ES
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000096:biosynthesis; D063646:Carcinogenesis / Q000187:drug effects; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D004127:Dimethylhydrazines / Q000633:toxicity; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D047311:Luteolin / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D002272:Carcinoembryonic Antigen; D004127:Dimethylhydrazines; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D047311:Luteolin; D001241:Aspirin