title: The most important risk factors for avascular necrosis and chondrolysis in patients with slipped capital femoral epiphysis.
abstract: OBJECTIVE
  To study the most important risk factors for avascular necrosis (AVN) and chondrolysis in children with slipped capital femoral epiphysis (SCFE).
  
  
  METHODS
  Thirty patients with SCFE, who were surgically treated by single-screw fixation with goodpositioning from 1998 to 2012, were reviewed (22 male and 8 female patients, 35 hips; bilateral involvement in 1 male and 4 female patients). The following clinical and radiographic data were analyzed: age, sex, weight, height, onset, grading, stability, severity, history of trauma, anterior physeal separation (APS), and major complications such as AVN and chondrolysis. The results were reported according to the Heyman and Herndon criteria as excellent, good, fair, poor or failure. Multiple logistic regression was used to identify multivariate predictors of osteonecrosis and chondrolysis.
  
  
  RESULTS
  The mean patient age was 11.9 years. The right and left sides were affected in 45.7% and 54.3% of patients, respectively. There were 2 acute (5.7%), 26 chronic (74.3%), 5 acute-on-chronic (14.3%), and 2 preslips (5.7%). Five hips were unstable (14.3%), and 30 were stable (85.7%). There were 14 mild slips (40%), 6 moderate slips (17.1%), and 15 severe slips (42.9%). Thirteen hips (37.1%) had a history oftrauma. APS waspresent in 12 hips (34.3%). Nine hips hadAVN (25.7%), 7 had chondrolysis (20.0%), and 10 had both AVN and chondrolysis (28.6%). Clinical results were excellent, good, fair, poor, and failure in 13 (37.1%), 12 (34.3%), 6(17.1%), 2 (5.7%), and 2 hips (5.7%), respectively. Univariate analysis revealed that the statistically significant risk factors (p < 0.05) for A VN and chondrolysis were the presence of APS (p = 0.000), acute and acute-on-chronic onset (p = 0.001), moderate and severe grades (p = 0. 002), instability (p = 0.17), and a history of trauma (p = 0.02). Multivariate analysis revealed that the presence of APS was the only risk factor for AVN and chondrolysis with the highest statistical significance (p = 0.000).
  
  
  CONCLUSIONS
  Single-screw fixation gave good and reliable outcomes in most cases. APS is the most important risk factor for AVN and chondrolysis in patients with SCFE. The optimal alternative treatment to reduce this major complication should be further studied, especially in patients with acute or acute-on-chronic slips, unstable hips, a history of trauma, or APS.
authors.forename: Kamolporn
authors.initials: K
authors.lastname: Kaewpornsawan
authors.forename: Pawaris
authors.initials: P
authors.lastname: Sukvanich
authors.forename: Perajit
authors.initials: P
authors.lastname: Eamsobhana
authors.forename: Chatupon
authors.initials: C
authors.lastname: Chotigavanichaya
mesh_terms: D000293:Adolescent; D002358:Cartilage, Articular / Q000293:injuries*; D002648:Child; D004838:Epiphyses / Q000000981:diagnostic imaging / Q000293:injuries; D005260:Female; D005271:Femur Head Necrosis / Q000209:etiology*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011859:Radiography; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D060048:Slipped Capital Femoral Epiphyses / Q000150:complications* / Q000601:surgery