title: Red cell distribution width to platelet ratio: new and promising prognostic marker in acute pancreatitis.
abstract: OBJECTIVE
  To evaluate the accuracy of red cell distribution width (RDW) to platelet ratio (RPR) to predict in-hospital mortality in acute pancreatitis (AP).
  
  
  METHODS
  Between January 2010 and June 2012, 102 patients with AP were recruited to the study. In this retrospective cohort study, for all subjects, demographic data on hospital admission, AP etiology, co-morbid diseases, organ failure assessment, laboratory parameters and length of hospital stay were examined. Additionally, we used a non-invasive prediction method in addition to the RPR to evaluate the disease severity. Multivariate logistic regression analyses were used to evaluate the impact of RPR on hospital admission to predict mortality.
  
  
  RESULTS
  The male-female ratio (59/43) was 1.37 with a median age of 56.5 years (17-89 years). In both univariate and multivariate analyses, RDW and RPR were presented as independent and significant variables on admission to predict mortality. The RPR obtained on hospital admission was persistently higher among non-survivors than among survivors (P < 0.0001). The median RPR was 0.000087 in the non-survivor group and 0.000058 in the survivor group. RPR with a cutoff value of 0.000067 presented an area under the curve of 0.783 (95%CI: 0.688-0.878) in receiver operating characteristic curves and could predict the mortality of approximately 80% of the patients.
  
  
  CONCLUSIONS
  We identified RPR as a valuable, novel laboratory test to predict mortality in AP.
authors.affiliation: Erdinç Çetinkaya, Kazım Şenol, Barış Saylam, Mesut Tez, Department of General Surgery, Ankara Numune Education and Research Hospital, 06500 Ankara, Turkey.
authors.forename: Erdinç
authors.initials: E
authors.lastname: Cetinkaya
authors.affiliation: Erdinç Çetinkaya, Kazım Şenol, Barış Saylam, Mesut Tez, Department of General Surgery, Ankara Numune Education and Research Hospital, 06500 Ankara, Turkey.
authors.forename: Kazım
authors.initials: K
authors.lastname: Senol
authors.affiliation: Erdinç Çetinkaya, Kazım Şenol, Barış Saylam, Mesut Tez, Department of General Surgery, Ankara Numune Education and Research Hospital, 06500 Ankara, Turkey.
authors.forename: Barış
authors.initials: B
authors.lastname: Saylam
authors.affiliation: Erdinç Çetinkaya, Kazım Şenol, Barış Saylam, Mesut Tez, Department of General Surgery, Ankara Numune Education and Research Hospital, 06500 Ankara, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Tez
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D016009:Chi-Square Distribution; D004909:Erythrocyte Indices; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D010343:Patient Admission; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult
keywords: Acute pancreatitis; Red cell distribution width; Red cell distribution width to platelet ratio