title: Recovery from acute kidney injury: the role of biomarkers.
abstract: Establishing the prognosis for recovery has enormous clinical implications. The appropriate definition of renal recovery depends on the stage of acute kidney injury (AKI). As definitions of AKI have broadened to encompass small increases in serum creatinine, definitions of recovery have broadened from becoming dialysis independent to full recovery of baseline glomerular function. Damage and functional biomarkers can assist in the prediction of recovery. Both decreases in damage biomarker concentration and increases in kidney function predict recovery. Structural biomarkers that directly predict recovery are awaited.
authors.affiliation: Department of Nephrology, Prince of Wales Hospital, and Prince of Wales Clinical School, University of New South Wales, Sydney, N.S.W., Australia.
authors.forename: Zoltán H
authors.initials: ZH
authors.lastname: Endre
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D000209:Acute-Phase Proteins / Q000652:urine; D051017:Apoptosis Regulatory Proteins / Q000097:blood; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D001026:Coronary Artery Bypass; D003404:Creatinine / Q000097:blood; D003422:Critical Care; D000074049:Cytokine TWEAK; D003937:Diagnosis, Differential; D004231:Diuresis; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000175:diagnosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology; D016030:Kidney Transplantation; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood / Q000652:urine; D008562:Membrane Glycoproteins / Q000097:blood; D008565:Membrane Proteins / Q000097:blood; D010455:Peptides / Q000097:blood; D011183:Postoperative Complications / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000652:urine; D011991:Receptors, Virus / Q000097:blood; D020127:Recovery of Function; D017582:Renal Replacement Therapy; D015427:Reperfusion Injury / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology; D012720:Severity of Illness Index; D000071165:Trefoil Factor-3; D048069:Tumor Necrosis Factors / Q000097:blood
chemical_list: D000209:Acute-Phase Proteins; D051017:Apoptosis Regulatory Proteins; D015415:Biomarkers; D000074049:Cytokine TWEAK; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C000589760:IL18 protein, human; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D010455:Peptides; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; C082495:TFF3 protein, human; C109743:TNFSF12 protein, human; C497771:Tnfsf12 protein, rat; D000071165:Trefoil Factor-3; D048069:Tumor Necrosis Factors; C018524:N,N-dimethylarginine; D001120:Arginine; D003404:Creatinine