title: Total synthesis of tricladins A and B and identification of their absolute configuration.
abstract: A concise synthesis of both (S)- and (R)-enantiomers of tricladins A and B from l-Boc alanine was achieved. The diastereomeric intermediates were separated by chiral column chromatography, and the absolute configuration of the 2-position was assigned by observed NOE interactions with the known stereogenic center at the 5-position. By comparison of all synthesized final enantiomers with the corresponding natural products, we concluded that the natural tricladins A and B must have the (R)-configuration.
authors.affiliation: AMRI , 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, United States.
authors.forename: He
authors.initials: H
authors.lastname: Zhao
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Huang
authors.forename: Wen
authors.initials: W
authors.lastname: Chen