title: Clinical Inquiry: do oral contraceptives put women with a family history of breast cancer at increased risk?
abstract: A systematic review of the effect of combined OCPs on women with a family history of breast cancer found no additional increase in risk. Investigators identified 3 retrospective cohort studies (N=66,500, with 8500 cases) and 7 case-control studies (total 10,500 cases) from the past 40 years, most including women from the United States and Canada, but one including women from 5 continents.
authors.affiliation: Valley Family Medicine Residency, Renton, WA, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Freund
authors.forename: Gary
authors.initials: G
authors.lastname: Kelsberg
authors.forename: Sarah
authors.initials: S
authors.lastname: Safranek
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects; D016021:Epidemiologic Studies; D005260:Female; D019398:Genes, BRCA1 / Q000502:physiology*; D024522:Genes, BRCA2 / Q000502:physiology*; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D017410:Practice Guidelines as Topic; D018570:Risk Assessment / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D003277:Contraceptives, Oral, Combined