title: [Fatal outcome after overdosage with antidepressants].
abstract: Serotonin syndrome (SS) is a complication after overdosage with antidepressants. SS increases the level of circulating serotonin. Fatal outcome of SS is most often seen in cases where there has been an overdosage with selective serotonin reuptake inhibitors (SSRI)/selective noradrenaline reuptake inhibitors (SNRI) in combination with other serotonin increasing drugs. This case report describes the rapid development of symptoms in a 54-year-old man who ingested a total amount of 6.5 g of SSRI and SNRI drugs as the only drug types. It proves the importance of being aware of the symptoms of SS when the patient is first seen in the emergency department.
authors.affiliation: Lungemedicinsk Afdeling, Aarhus Universitetshospital, Nørrebrogade 44, 8000 Aarhus C. larskris@rm.dk.
authors.forename: Martin Faurholdt
authors.initials: MF
authors.lastname: Gude
authors.forename: Lisbet Tokkesdal
authors.initials: LT
authors.lastname: Jensen
authors.forename: Lars
authors.initials: L
authors.lastname: Bjerre-Kristensen
mesh_terms: D000928:Antidepressive Agents / Q000506:poisoning* / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy; D062787:Drug Overdose; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D020230:Serotonin Syndrome / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000506:poisoning* / Q000627:therapeutic use; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors / Q000506:poisoning* / Q000627:therapeutic use; D013405:Suicide
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors; D000068760:Serotonin and Noradrenaline Reuptake Inhibitors