title: Isolation and characterization of new onionins A2 and A3 from Allium cepa, and of onionins A1, A2, and A3 from Allium fistulosum.
abstract: In this study, the new stable sulfur-containing compounds onionins A2 (1) and A3 (2) were isolated from the acetone extracts of the bulbs of Allium cepa L. and identified as the stereoisomers of onionin A1 discovered in our previous study. Their chemical structures, 3,4-dimethyl-5-(1E-propenyl)-tetrahydrothiophene-2-sulfenic acid-S-oxides, were characterized using various spectroscopic techniques. In addition, 1 and 2 together with onionin A1 were successfully isolated from the leaves of the Welsh onion, Allium fistulosum L. The onion-extracted fractions showed good potential to inhibit the polarization of M2 activated macrophages, indicating their possible ability to inhibit tumor cell proliferation.
authors.affiliation: Faculty of Pharmaceutical Sciences, Sojo University.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
authors.forename: Yukio
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Rino
authors.initials: R
authors.lastname: Kudo
authors.forename: Koki
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ikeda
authors.forename: Kotaro
authors.initials: K
authors.lastname: Murakami
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajimoto
authors.forename: Motohiro
authors.initials: M
authors.lastname: Takeya
mesh_terms: D015703:Antigens, CD / Q000032:analysis / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis / Q000276:immunology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D007155:Immunologic Factors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D019697:Onions / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000032:analysis / Q000276:immunology; D013434:Sulfenic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013876:Thiophenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000972:Antineoplastic Agents, Phytogenic; D000098902:CD163 Antigen; D007155:Immunologic Factors; D011956:Receptors, Cell Surface; D013434:Sulfenic Acids; D013876:Thiophenes; C121030:tetrahydrothiophene