title: Neuronal development in Caenorhabditis elegans is regulated by inhibition of an MLK MAP kinase pathway.
abstract: We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, like RPM-1, is a potential inhibitor of kinases in the MLK-1 pathway.
authors.affiliation: Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Scott T
authors.initials: ST
authors.lastname: Baker
authors.affiliation: Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458.
authors.forename: Shane M
authors.initials: SM
authors.lastname: Turgeon
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Erik D
authors.initials: ED
authors.lastname: Tulgren
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Jeanne
authors.initials: J
authors.lastname: Wigant
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455.
authors.forename: Omeed
authors.initials: O
authors.lastname: Rahimi
authors.affiliation: Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458.
authors.forename: Karla J
authors.initials: KJ
authors.lastname: Opperman
authors.affiliation: Department of Neuroscience, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458 bgrill@scripps.edu.
authors.forename: Brock
authors.initials: B
authors.lastname: Grill
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000254:growth & development; D029742:Caenorhabditis elegans Proteins / Q000235:genetics* / Q000378:metabolism; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism; D048031:JNK Mitogen-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D048369:MAP Kinase Kinase 1 / Q000235:genetics* / Q000378:metabolism; D020935:MAP Kinase Signaling System; D055495:Neurogenesis; D013569:Synapses / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D020662:Guanine Nucleotide Exchange Factors; C409634:RPM-1 protein, C elegans; D048031:JNK Mitogen-Activated Protein Kinases; C524496:KGB-1 protein, C elegans; D048369:MAP Kinase Kinase 1
keywords: JNK; MAP kinase; RPM-1; axon; synapse