title: Bone mineral density and factors influencing it in Asian Indian population with type 2 diabetes mellitus.
abstract: OBJECTIVE
  To assess bone mineral density (BMD) in type 2 diabetes mellitus (T2DM) patients and its relation, if any, to clinical, hormonal and metabolic factors.
  
  
  METHODS
  A prospective evaluation of 194 T2DM patients (97 men and 97 women) was carried out. BMD was done with dual energy X-ray absorptiometry (DXA) at the lumbar spine and total hip. Physical activity, nutritional intake and sunlight exposure were calculated. Biochemical and hormonal tests included serum 25 hydroxy vitamin D [25(OH) D], parathyroid hormone, estrogen, testosterone and urinary calcium-creatinine ratio. Glycosylated hemoglobin and complete lipid profiles were done in patients with diabetes. Five hundred and seventy one non-diabetic controls (262 males and 309 females) were evaluated for BMD alone.
  
  
  RESULTS
  BMD was normal (Z score > -2) in 156 (80.5%) and low (Z score ≤ -2) in 38 (19.5%) patients in the diabetes study group. BMD in the diabetes group was significantly higher than the control group in both sexes at the hip and spine. The difference was no longer significant on analysis of a BMI matched control subgroup. Weight and BMI showed significant correlation to BMD. Duration of T2DM, degree of glycemic control, use of drugs like statins and thiazolidinediones, 25(OH) D levels, calcium intake, sunlight exposure and physical activity did not significantly affect BMD in this cohort of individuals with diabetes.
  
  
  CONCLUSIONS
  Bone mineral density of Asian Indian T2DM subjects was similar to that of healthy volunteers in this study.
authors.affiliation: Department of Endocrinology, JIPMER, Puducherry, India.
authors.forename: Sadishkumar
authors.initials: S
authors.lastname: Kamalanathan
authors.affiliation: Consultant of Endocrinology, MIMS Hospital, Calicut, India.
authors.forename: Vimal
authors.initials: V
authors.lastname: Nambiar
authors.affiliation: Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, India.
authors.forename: Vyankatesh
authors.initials: V
authors.lastname: Shivane
authors.affiliation: Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, India.
authors.forename: Tushar
authors.initials: T
authors.lastname: Bandgar
authors.affiliation: Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, India.
authors.forename: Padmavathy
authors.initials: P
authors.lastname: Menon
authors.affiliation: Department of Endocrinology, Seth G.S. Medical College and KEM Hospital, Mumbai, India.
authors.forename: Nalini
authors.initials: N
authors.lastname: Shah
keywords: Asian Indian; bone mineral density; obesity; type 2 diabetes mellitus; vitamin D deficiency