title: Highlights of the Latest Advances in Research on CDK Inhibitors.
abstract: Uncontrolled proliferation is the hallmark of cancer and other proliferative disorders and abnormal cell cycle regulation is, therefore, common in these diseases. Cyclin-dependent kinases (CDKs) play a crucial role in the control of the cell cycle and proliferation. These kinases are frequently deregulated in various cancers, viral infections, neurodegenerative diseases, ischemia and some proliferative disorders. This led to a rigorous pursuit for small-molecule CDK inhibitors for therapeutic uses. Early efforts to block CDKs with nonselective CDK inhibitors led to little specificity and efficacy but apparent toxicity, but the recent advance of selective CDK inhibitors allowed the first successful efforts to target these kinases for the therapies of several diseases. Major ongoing efforts are to develop CDK inhibitors as monotherapies and rational combinations with chemotherapy and other targeted drugs.
authors.affiliation: CALIPHO Group, Swiss Institute of Bioinformatics, CMU-1, rue Michel Servet' Geneva 4 CH-1211, Switzerland. j.cicenas@mapkinases.eu.
authors.forename: Jonas
authors.initials: J
authors.lastname: Cicenas
authors.affiliation: MAP Kinase Resource, Bern CH-3027, Switzerland. karthikms2004@gmail.com.
authors.forename: Karthik
authors.initials: K
authors.lastname: Kalyan
authors.affiliation: MAP Kinase Resource, Bern CH-3027, Switzerland. a.sorokinas@mapkinases.eu.
authors.forename: Aleksandras
authors.initials: A
authors.lastname: Sorokinas
authors.affiliation: MAP Kinase Resource, Bern CH-3027, Switzerland. asta.jatulyte@gmail.com.
authors.forename: Asta
authors.initials: A
authors.lastname: Jatulyte
authors.affiliation: Nature Research Centre, Vilnius LT-08412, Lithuania. deividas_valiunas@yahoo.com.
authors.forename: Deividas
authors.initials: D
authors.lastname: Valiunas
authors.affiliation: Proteomics Centre, Vilnius University Institute of Biochemistry, Vilnius LT-08662, Lithuania. algirdas.kaupinis@gf.vu.lt.
authors.forename: Algirdas
authors.initials: A
authors.lastname: Kaupinis
authors.affiliation: Proteomics Centre, Vilnius University Institute of Biochemistry, Vilnius LT-08662, Lithuania. mindaugas.valius@bchi.vu.lt.
authors.forename: Mindaugas
authors.initials: M
authors.lastname: Valius