title: How can we improve oral contraceptive success in obese women?
abstract: A rapid increase in obesity rates worldwide further underscores the importance of better understanding the pharmacokinetic alterations in this sub-population and the subsequent effects on pharmacotherapeutics. Pharmacokinetics of contraceptive steroids is altered in obese oral contraceptive users, which may in turn impact efficacy. Our study has identified several dosing strategies that offset these pharmacokinetic changes and may improve effectiveness for obese oral contraception users.
authors.affiliation: Oregon State University/Oregon Health and Science University - Pharm Practice 2730 SW Moody Ave, Portland, OR, 97201, USA.
authors.forename: Ganesh
authors.initials: G
authors.lastname: Cherala
authors.forename: Alison
authors.initials: A
authors.lastname: Edelman
mesh_terms: D003267:Contraception / Q000379:methods; D003276:Contraceptives, Oral / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D009765:Obesity / Q000378:metabolism*
chemical_list: D003276:Contraceptives, Oral
keywords: drug failure; obesity; oral contraception; pharmacokinetics; steroidal hormones