title: Precision medicine for prostate cancer.
abstract: Metastatic castration-resistant prostate cancer remains a lethal disease despite considerable progress in systemic therapy over the past decade. The recent advances in genomic sequencing have improved the molecular classification of prostate cancer. The translation of genomic data into clinically relevant prognostic and predictive biomarkers to guide therapy is still in its infancy and therapies for castration-resistant prostate cancer are still used empirically. We discuss these genomic aberrations in more detail, focusing on androgen receptor signaling, ETS transcription factor gene rearrangements and PTEN loss. The incorporation of this genomic data within early phase clinical trials is evolving and may prove significant in advancing personalized care in prostate cancer.
authors.affiliation: Department of Medical Oncology, Guy's Hospital, London, SE1 9RT, UK.
authors.forename: Myria
authors.initials: M
authors.lastname: Galazi
authors.forename: Alejo
authors.initials: A
authors.lastname: Rodriguez-Vida
authors.forename: Tony
authors.initials: T
authors.lastname: Ng
authors.forename: Malcolm
authors.initials: M
authors.lastname: Mason
authors.forename: Simon
authors.initials: S
authors.lastname: Chowdhury
mesh_terms: D059002:Androgen Receptor Antagonists / Q000008:administration & dosage; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000235:genetics; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy
chemical_list: D059002:Androgen Receptor Antagonists; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
keywords: ETS fusion gene rearrangements; PI3K/AKT/mTOR pathway; PTEN loss; androgen receptor; castration-resistant prostate cancer; precision medicine