title: The relationship between estimated GFR based on the CKD-EPI formula and renal inulin clearance in potential kidney donors.
abstract: It is not yet clear whether or not renal function in the living donor can be sufficiently assessed by estimated glomerular filtration rate (GFR) using creatinine-based equations. The present paper investigates the relationship between GFR values determined using renal inulin clearance (Cin) and those estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. Our study was performed in 287 potential kidney donors with a mean age of 48 ± 10 years. Mean Cin was 1.47 ± 0.28 (1.10 - 2.50) mL/s/1.73 m2. Total bias when using the CKDEPI formula was -0.0183 mL/s/1.73 m2, precision 0.263 mL/s/1.73 m2, and accuracy 90.6% within ± 30% of Cin. The sensitivity of CKD-EPI to estimate a decrease in Cin below 1.33 mL/s/1.73 m2 was 50.5%, with an 85% specificity of detecting a value above the cutoff. Receiver-operating curve analysis for the above produced an area under the curve of 0.766 ± 0.0285 (CI 0.712 - 0.813). For donor screening purposes, CKD-EPI should be interpreted with great caution.
authors.forename: Otto
authors.initials: O
authors.lastname: Schück
authors.forename: Vladimir
authors.initials: V
authors.lastname: Teplan
authors.forename: Jan
authors.initials: J
authors.lastname: Maly
authors.forename: Janka
authors.initials: J
authors.lastname: Franekova
authors.forename: Hana
authors.initials: H
authors.lastname: Malinska
authors.forename: Milena
authors.initials: M
authors.lastname: Stollova
authors.forename: Irena
authors.initials: I
authors.lastname: Latova
authors.forename: Jana
authors.initials: J
authors.lastname: Urbanova
authors.forename: Jelena
authors.initials: J
authors.lastname: Skibova
authors.forename: Ondrej
authors.initials: O
authors.lastname: Viklicky
mesh_terms: D000328:Adult; D000368:Aged; D019540:Area Under Curve; D003404:Creatinine / Q000097:blood / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007444:Inulin / Q000097:blood / Q000652:urine*; D007668:Kidney / Q000378:metabolism; D007677:Kidney Function Tests / Q000706:statistics & numerical data; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D007444:Inulin; D003404:Creatinine