title: Experimental investigation of pharmacodynamics and pharmacokinetics of carbamazepine nanoemulsion.
abstract: Anticonvulsant activity and pharmacokinetics of nanoemulsion and unmodified substance of carbamazepine were compared in experiments on mice. Carbamazepine nanoemulsion demonstrated significant anticonvulsant activity and was superior to unmodified substance of carbamazepine against seizures induced by maximum electric shock and picrotoxin. Relative bioavailability of carbamazepine after administration of nanoemulsion was 160% compared to unmodified substance. Carbamazepine nanoemulsion more effectively penetrated through BBB by 1.5 times in comparison with unmodified substance.
authors.affiliation: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia, prokhor_chembio@yandex.ru.
authors.forename: D I
authors.initials: DI
authors.lastname: Prokhorov
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: D A
authors.initials: DA
authors.lastname: Abramov
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: I G
authors.initials: IG
authors.lastname: Kapitsa
authors.forename: A S
authors.initials: AS
authors.lastname: Zhuravko
authors.forename: M V
authors.initials: MV
authors.lastname: Shiriaeva
authors.forename: A P
authors.initials: AP
authors.lastname: Kaplun
authors.forename: R D
authors.initials: RD
authors.lastname: Seifulla
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001682:Biological Availability; D001812:Blood-Brain Barrier / Q000378:metabolism; D004049:Diethylcarbamazine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004558:Electric Stimulation; D004655:Emulsions / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D049329:Nanostructures / Q000008:administration & dosage; D010852:Picrotoxin / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants; D004049:Diethylcarbamazine; D004655:Emulsions; D010852:Picrotoxin