title: Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes.
abstract: MYC family oncoproteins (MYC, N‐MYC and L‐MYC) function as basic helix‐loop‐helix‐leucine zipper (bHLH‐Zip) transcription factors that are activated (i.e., overexpressed) in well over half of all human malignancies (Boxer & Dang, 2001; Beroukhim et al, 2010). In this issue of EMBO Molecular Medicine, Eilers and colleagues (Peter et al, 2014) describe a novel approach to disable MYC, whereby inhibition of the ubiquitin ligase HUWE1 stabilizes MIZ1 and leads to the selective repression of MYC‐activated target genes.
authors.affiliation: Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: Franz X
authors.initials: FX
authors.lastname: Schaub
authors.affiliation: Department of Tumor Biology, The Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors.forename: John L
authors.initials: JL
authors.lastname: Cleveland
mesh_terms: D000818:Animals; D015179:Colorectal Neoplasms / Q000201:enzymology*; D006801:Humans; D016274:Oncogene Protein p55(v-myc) / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000494:pharmacology*; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors*
chemical_list: D016274:Oncogene Protein p55(v-myc); D054852:Small Molecule Libraries; D044767:Ubiquitin-Protein Ligases