title: [Analysis of mature T-cell and NK-cell lymphoma with CD30 expression based on latest WHO classification].
abstract: OBJECTIVE
  To investigate the frequency of different types of mature T- and NK-cell lymphomas diagnosed in a 4-year period at Sun Yat-sen University Cancer Center, and to study baseline CD30 for potential anti-CD30 targeted therapy in mature T- and NK-cell lymphoma.
  
  
  METHODS
  All cases of mature T- and NK-cell lymphoma diagnosed at Sun Yat-sen University Cancer Center from September 1, 2009 to August 31, 2013, were reviewed. Paraffin-blocks of available 164 consecutive cases were stained for CD30 immunohistochemistry using EnVision protocol.
  
  
  RESULTS
  A total of 625 cases of mature T- and NK-cell lymphomas were diagnosed and the most common type was extranodal NK/T cell lymphoma (ENKTL), nasal type 319 (51.0%) cases, followed by angioimmunoblastic T-cell lymphoma (AITL) (119 cases, 19.0%), peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) (81 cases, 13.0%), and anaplastic large-cell lymphoma (ALCL), including 48 cases (7.7%) of systematic ALCL and 11 cases (1.8%) of primary cutaneous ALCL. Besides ALCL, ENKTL had the highest expression rate of CD30 among the 164 cases, with positivity observed in 41 cases (62.1%, 41/66). Only 1 case of PTCL-NOS was CD30 positive. CD30 was not expressed in all 28 cases of AITL and other rare types of mature T- and NK-cell lymphoma.
  
  
  CONCLUSIONS
  The frequency of different types of mature T- and NK-cell lymphoma encountered at Sun Yat-sen University Cancer Center was similar to that seen in other areas of China and other Asia countries. CD30 expression is different among several types of mature T- and NK-cell lymphoma. In addition to ALCL, ENKTL has the highest expression rate of CD30, which may be a candidate disease for anti-CD30 targeted therapy.
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Shumei
authors.initials: S
authors.lastname: Yan
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Yihong
authors.initials: Y
authors.lastname: Ling
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Yili
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
authors.forename: Muyan
authors.initials: M
authors.lastname: Cai
authors.affiliation: Department of Pathology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China. E-mail:raohl@sysucc.org.cn.
authors.forename: Huilan
authors.initials: H
authors.lastname: Rao
mesh_terms: D002681:China / Q000453:epidemiology; D006801:Humans; D007150:Immunohistochemistry; D007694:Killer Cells, Natural; D054391:Lymphoma, Extranodal NK-T-Cell / Q000453:epidemiology* / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000453:epidemiology* / Q000473:pathology; D054446:Lymphoma, Primary Cutaneous Anaplastic Large Cell / Q000453:epidemiology* / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000453:epidemiology* / Q000473:pathology; D013601:T-Lymphocytes