title: Oxidative stress status and placental implications in diabetic rats undergoing swimming exercise after embryonic implantation.
abstract: The potential benefits and risks of physical exercise on fetal development during pregnancy remain unclear. The aim was to analyze maternal oxidative stress status and the placental morphometry to relate to intrauterine growth restriction (IUGR) from diabetic female rats submitted to swimming program after embryonic implantation. Pregnant Wistar rats were distributed into 4 groups (11 animals/group): control-nondiabetic sedentary rats, control exercised-nondiabetic exercised rats, diabetic-diabetic sedentary rats, and diabetic exercised-diabetic exercised rats. A swimming program was used as an exercise model. At the end of pregnancy, the maternal oxidative stress status, placental morphology, and fetal weight were analyzed. The swimming program was not efficient to reduce the hyperglycemia-induced oxidative stress. This fact impaired placental development, resulting in altered blood flow and energy reserves, which contributed to a deficient exchange of nutrients and oxygen for the fetal development, leading to IUGR.
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil Laboratory of General Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, University Center of Araguaia, Federal University of Mato Grosso, Barra do Garças, Mato Grosso, Brazil gtvolpato@yahoo.com.
authors.forename: Gustavo Tadeu
authors.initials: GT
authors.lastname: Volpato
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Débora Cristina
authors.initials: DC
authors.lastname: Damasceno
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Yuri Karen
authors.initials: YK
authors.lastname: Sinzato
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Viviane Maria
authors.initials: VM
authors.lastname: Ribeiro
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Marilza Vieira Cunha
authors.initials: MV
authors.lastname: Rudge
authors.affiliation: Laboratory of Experimental Research on Gynecology and Obstetrics, Botucatu Medical School, Univ Estadual Paulista_Unesp, Botucatu, São Paulo, Brazil.
authors.forename: Iracema Mattos Paranhos
authors.initials: IM
authors.lastname: Calderon
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D010064:Embryo Implantation; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D020567:Fetal Weight; D018384:Oxidative Stress; D010920:Placenta / Q000473:pathology / Q000503:physiopathology*; D011247:Pregnancy; D017208:Rats, Wistar; D013550:Swimming; D013997:Time Factors
chemical_list: D015415:Biomarkers; D001786:Blood Glucose
keywords: diabetes; oxidative stress; physical exercise; placenta; pregnancy