title: Spontaneous harderian gland adenocarcinoma in a female f344 rat: a case report.
abstract: Harderian gland tumors are extremely rare in female F344 rats. An expansive enlarging lesion of the Harderian gland with compression, distortion and invasion of the surrounding muscle was found in a 110-week-old female F344/DuCrj rat, which was diagnosed as a Harderian gland adenocarcinoma. Epithelial growth patterns such as glandular, lobular, papillary and duct forming patterns were exhibited in most areas of the tumor. The tumor cells were pleomorphic and atypical. In one part of the tumor, poorly differentiated areas were found. This case was observed in the middle dose group of a carcinogenicity study of diphenylamine, which was not carcinogenic, we determine to be this case was a spontaneous tumor.
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Senoh
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Taku
authors.initials: T
authors.lastname: Katagiri
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Takanobu
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Umeda
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Aiso
authors.affiliation: Japan Bioassay Research Center, Hadano, Kanagawa 257-0015, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
keywords: F344; Harderian gland; adenocarcinoma; adenoma; rat; spontaneous tumor