title: Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI).
  
  
  RESULTS
  Patients (n = 338) underwent 320 × 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI.
  
  
  CONCLUSIONS
  LVM was independently associated with the presence of coronary artery atherosclerosis and MI.
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Satoru
authors.initials: S
authors.lastname: Kishi
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Tiago A
authors.initials: TA
authors.lastname: Magalhaes
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Richard T
authors.initials: RT
authors.lastname: George
authors.affiliation: Department of Radiology, Charité Medical School, Humboldt-Universität zu Berline and Freie Universität zu Berlin, Berlin, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Dewey
authors.affiliation: Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Laham
authors.affiliation: Division of Cardiology, St. Luke's International Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Niinuma
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Lisa Aronson
authors.initials: LA
authors.lastname: Friedman
authors.affiliation: Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Cox
authors.affiliation: Department of Radiology, Keio University, Tokyo, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tanami
authors.affiliation: Toshiba Medical Systems Europe B.V., Zoetermeer, The Netherlands.
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Vavere
authors.affiliation: Department of Radiology, Mie University Hospital, Tsu, Japan.
authors.forename: Kakuya
authors.initials: K
authors.lastname: Kitagawa
authors.affiliation: Advanced Cardiovascular Imaging Group, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Marcus Y
authors.initials: MY
authors.lastname: Chen
authors.affiliation: Radiology Sector, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors.forename: Cesar H
authors.initials: CH
authors.lastname: Nomura
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Brinker
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Rybicki
authors.affiliation: Department of Radiology, Brigham and Women's Hospital, Harvard University, Boston, MA, USA.
authors.forename: Marcelo F
authors.initials: MF
authors.lastname: Di Carli
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Armin
authors.initials: A
authors.lastname: Arbab-Zadeh
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Blalock 524, 600 N. Wolfe Street, Baltimore, MD 21287, USA jlima@jhmi.edu.
authors.forename: Joao A C
authors.initials: JA
authors.lastname: Lima
mesh_terms: D000368:Aged; D000465:Algorithms; D057791:Cardiac Imaging Techniques; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D011446:Prospective Studies
keywords: Atheroma volume; Coronary atherosclerosis; Left ventricular mass; Myocardial ischaemia