title: Feline urinary tract pathogens: prevalence of bacterial species and antimicrobial resistance over a 10-year period.
abstract: The purpose of this retrospective study was to identify bacterial species in cats with bacterial urinary tract infections (UTIs) and to investigate their antimicrobial susceptibilities over a 10-year period. Three hundred and thirty cultures from 280 cats were included in the study. The mean age of affected cats was 9.9 years; female cats with bacterial UTIs were significantly older than male cats with UTIs. The most common pathogen identified was Escherichia coli (42.3 per cent), followed by Streptococcus species (19.3 per cent), Staphylococcus species (15.6 per cent), Enterococcus species (6.6 per cent) and Micrococcaceae (5.8 per cent). Forty specimens (12.1 per cent) yielded growth of more than one isolate. Streptococcus and Enterococcus isolates were resistant to a significantly higher number of antimicrobial agents than E coli and Staphylococcus species isolates. Applying the formula to select rational antimicrobial therapy, bacterial isolates were most likely to be susceptible to nitrofurantoin, amoxicillin clavulanic acid, enrofloxacin and gentamicin. The antimicrobial impact factor for nitrofurantoin increased significantly over the 10-year period, whereas there was no significant change in antimicrobial impact factors for doxycycline, trimethoprim-sulfamethoxazole, gentamicin, enrofloxacin, cephalothin and amoxicillin clavulanic acid. The detected changes in in vitro antimicrobial efficacy could help to develop hospital-specific guidelines for antimicrobial use to prevent the further development of resistance in feline uropathogens.
authors.affiliation: Clinic of Small Animal Medicine, LMU Munich, Veterinärstr. 13, Munich 80539, Germany.
authors.forename: Roswitha
authors.initials: R
authors.lastname: Dorsch
authors.affiliation: Clinic of Small Animal Medicine, LMU Munich, Veterinärstr. 13, Munich 80539, Germany.
authors.forename: Clara
authors.initials: C
authors.lastname: von Vopelius-Feldt
authors.affiliation: Institute for Infectious Diseases and Zoonoses, LMU Munich, Veterinärstr. 13, Munich 80539, Germany.
authors.forename: Georg
authors.initials: G
authors.lastname: Wolf
authors.affiliation: Institute for Infectious Diseases and Zoonoses, LMU Munich, Veterinärstr. 13, Munich 80539, Germany.
authors.forename: Reinhard K
authors.initials: RK
authors.lastname: Straubinger
authors.affiliation: Clinic of Small Animal Medicine, LMU Munich, Veterinärstr. 13, Munich 80539, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Hartmann
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification*; D002371:Cat Diseases / Q000188:drug therapy / Q000382:microbiology*; D002415:Cats; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects / Q000302:isolation & purification; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D008297:Male; D008835:Micrococcaceae / Q000187:drug effects / Q000302:isolation & purification; D015995:Prevalence; D012189:Retrospective Studies; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
chemical_list: D000900:Anti-Bacterial Agents
keywords: Cats; Microbiology; Urinary tract; culture and susceptibility