title: Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
abstract: OBJECTIVE
  Previous studies concerning the role of CD86 polymorphisms (rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this study was to investigate the role of common polymorphisms in the risk of cancer by meta-analysis.
  
  
  METHODS
  By using the search terms Cluster of Differentiation 86/CD86/B7-2/polymorphism/polymorphisms/cancer, we searched PubMed, Embase, CNKI, and Wanfang and identified four studies for rs1129055 (2137 subjects) and rs17281995 (2856 subjects) respectively. Cancer risk was estimated by odds ratio (OR) and 95% confidence interval (95% CI).
  
  
  RESULTS
  Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49-0.79; P(het)., 0.996). Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74-0.93; P(het)., 0.987; OR, 0.63; 95% CI, 0.50-0.79; P(het)., 0.973). In addition, we found genotypes of rs17281995 had a major effect on overall cancer risk (CC versus GG: OR, 2.38; 95% CI, 1.43-3.95; P(het)., 0.433; C versus G: OR, 1.23; 95% CI, 1.06-1.43; P(het)., 0.521; CC versus GC+GG: OR, 2.38; 95% CI, 1.45-3.93; P(het)., 0.443). The association was also observed in Caucasians and colorectal cancer. No obvious publication bias was detected in this meta-analysis.
  
  
  CONCLUSIONS
  These data reveal that rs1129055 may have protective effects on cancer risk in Asians and that rs17281995 is likely to contribute to risk of cancer, particularly colorectal cancer in Caucasians.
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Peiliang
authors.initials: P
authors.lastname: Geng
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Lisha
authors.initials: L
authors.lastname: Xiang
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Yunmei
authors.initials: Y
authors.lastname: Liao
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Ou
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Ganfeng
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Hongtao
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zeng
authors.affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.
authors.forename: Houjie
authors.initials: H
authors.lastname: Liang
mesh_terms: D000483:Alleles; D051940:B7-2 Antigen / Q000235:genetics*; D016208:Databases, Factual; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide
chemical_list: D051940:B7-2 Antigen