title: Recombination and replication.
abstract: The links between recombination and replication have been appreciated for decades and it is now generally accepted that these two fundamental aspects of DNA metabolism are inseparable: Homologous recombination is essential for completion of DNA replication and vice versa. This review focuses on the roles that recombination enzymes play in underpinning genome duplication, aiding replication fork movement in the face of the many replisome barriers that challenge genome stability. These links have many conserved features across all domains of life, reflecting the conserved nature of the substrate for these reactions, DNA.
authors.affiliation: Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom.
authors.forename: Aisha H
authors.initials: AH
authors.lastname: Syeda
authors.affiliation: Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom.
authors.forename: Michelle
authors.initials: M
authors.lastname: Hawkins
authors.affiliation: Department of Biology, University of York, Wentworth Way, York YO10 5DD, United Kingdom.
authors.forename: Peter
authors.initials: P
authors.lastname: McGlynn
mesh_terms: D004247:DNA / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D042822:Genomic Instability; D059765:Homologous Recombination; D008957:Models, Genetic; D011995:Recombination, Genetic
chemical_list: D004247:DNA