title: Metal-free oxidative radical addition of carbonyl compounds to α,α-diaryl allylic alcohols: synthesis of highly functionalized ketones.
abstract: A metal-free direct alkylation of simple carbonyl compounds (ketones, esters, and amides) with α,α-diaryl allylic alcohols is described. The protocol provides facile access to highly functionalized dicarbonyl ketones by a radical addition/1,2-aryl migration cascade. The regioselectivity of the reaction was precisely controlled by the nature of the carbonyl compound.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123 (China).
authors.forename: Xue-Qiang
authors.initials: XQ
authors.lastname: Chu
authors.forename: Hua
authors.initials: H
authors.lastname: Meng
authors.forename: You
authors.initials: Y
authors.lastname: Zi
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Xu
authors.forename: Shun-Jun
authors.initials: SJ
authors.lastname: Ji
keywords: 1,2-aryl migration; allylic compounds; dicarbonyl compounds; domino reactions; radical reactions