title: [HTLV-1: Recent topics in epidemiologic, basic and clinical research].
abstract: Human T-cell leukemia virus type 1 (HTLV-1) belongs to Delta Retorviridae, and induces a malignancy of CD4+CD25+ T-cells, adult T-cell leukemia (ATL), and several chronic inflammatory diseases, such as HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 uveitis. A nationwide survey of HTLV-1-infected subjects, which was recently conducted by Japanese government, revealed that the numbers of HTLV-1 carriers and patients with HTLV-1-associated diseases have not decreased much over the last two decades in Japan. In contrast, novel findings on HTLV-1 dynamics in vivo and molecular mechanisms of its pathogenesis are accumulating by detailed analysis of newly identified viral and cellular factors, novel technologies such as next-generation sequencing, and appropriate animal models for HTLV-1 research. In this review, we summarize the recent progress of HTLV-1 research.
authors.affiliation: Laboratory of Virus Control, Institute for Virus Research, Kyoto University.
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Yasunaga
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
mesh_terms: D000818:Animals; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics; D002353:Carrier State / Q000453:epidemiology; D016355:Genes, pX / Q000235:genetics; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D007167:Immunotherapy; D007564:Japan / Q000453:epidemiology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000821:virology; D020411:Oligonucleotide Array Sequence Analysis; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology / Q000821:virology; D012367:RNA, Viral; D012191:Retroviridae Proteins; D014605:Uveitis / Q000821:virology; D014764:Viral Proteins / Q000235:genetics; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics / Q000502:physiology
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; C479751:HBZ protein, human T-cell leukemia virus type I; D012367:RNA, Viral; D012191:Retroviridae Proteins; D014764:Viral Proteins; D054334:Viral Regulatory and Accessory Proteins; C084305:p12I protein, Human T-lymphotropic virus 1