title: Impact of gastrectomy on high-density lipoprotein cholesterol elevation in nonobese patients during a 10-year follow-up.
abstract: OBJECTIVE
  The role of gastrectomy in glycemic control has been established in the current era of bariatric surgery for obesity. Gastrectomy in obese patients is associated with increased levels of high-density lipoprotein cholesterol (HDL-C). However, limited data on the effects of gastrectomy in nonobese patients are available. We herein investigated the long-term plasma lipid changes in nonobese patients who had undergone gastrectomy.
  
  
  METHODS
  Patients were enrolled as part of routine healthcare examinations from 1984 to 2003. Preoperative and postoperative data from patients who had undergone curative gastrectomy were analyzed for up to 10 years postoperatively. Three age- and sex-matched controls were assigned to each case.
  
  
  RESULTS
  Sixty-four nonobese patients without diabetes mellitus or a history of having taken lipid-lowering drugs who underwent curative gastrectomy during the study period were enrolled (60 subtotal gastrectomies, four total gastrectomies). The median follow-up period was 7.6 years. The mean body mass index was 9.6% lower one year after gastrectomy (p < 0.01), then plateaued with a slight recovery. Intriguingly, the preoperative HDL-C level was 21% higher one year after gastrectomy (p < 0.01), increased by another 30% six years after gastrectomy and remained at this level for the rest of the follow-up period. No significant changes in the HDL-C level were observed in the controls. The degree of HDL-C elevation was consistently significant, irrespective of the baseline triglyceride level, HDL-C level or body weight.
  
  
  CONCLUSIONS
  Gastrectomy in nonobese patients was associated with consistent and distinct long-term HDL-C elevations and body mass index reductions.
authors.affiliation: Department of Internal Medicine, Kanazawa University Graduate School of Medical Sciences.
authors.forename: Shigetsugu
authors.initials: S
authors.lastname: Tsuji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nohara
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Isao
authors.initials: I
authors.lastname: Yoshida
authors.forename: Rie
authors.initials: R
authors.lastname: Oka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Moriuchi
authors.forename: Tomomi
authors.initials: T
authors.lastname: Hagishita
authors.forename: Susumu
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Ayako
authors.initials: A
authors.lastname: Suzuki
authors.forename: Toshihide
authors.initials: T
authors.lastname: Okada
authors.forename: Masakazu
authors.initials: M
authors.lastname: Yamagishi
mesh_terms: D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism
chemical_list: D008076:Cholesterol, HDL