title: A biochemical study on ameliorative effect of green tea (Camellia sinensis) extract against contrast media induced acute kidney injury.
abstract: BACKGROUND
  Reactive oxygen species have been shown to be mediators of kidney injury and green tea polyphenols are potent-free radical scavengers.
  
  
  OBJECTIVE
  In this study we sought to examine whether green tea was able to protect renal toxicity induced by contrast media or not.
  
  
  METHODS
  In this experimental study 40 rats were randomly divided into four groups including: 1) control group 2) contrast media group 3) contrast media plus green tea 4) Green tea pretreatment and contrast media group. Blood urea Nitrogen (BUN) and serum creatinine were assessed for severity of kidney injury.
  
  
  RESULTS
  Serum creatinine level was higher in group II than in other groups (p<0.001). Treatment (group 3) or pretreatment (group 4) with green tea significantly reduced blood creatinine level when compared with contrast media group (group 2).
  
  
  CONCLUSIONS
  In this study, beneficial property of green tea, against renal toxicity of contrast media was observed. Green tea extract is an inexpensive, nontoxic, and effective treatment modality in individuals with a risk for acute kidney injury of contrast media.
authors.affiliation: Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Nasri
authors.affiliation: Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Azar
authors.initials: A
authors.lastname: Baradaran
authors.affiliation: Nickan Research Institute, Isfahan, Iran.
authors.forename: Parto
authors.initials: P
authors.lastname: Nasri
authors.affiliation: Nickan Research Institute, Isfahan, Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Hajian
authors.affiliation: Nickan Research Institute, Isfahan, Iran.
authors.forename: Armita
authors.initials: A
authors.lastname: Pour-Arian
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Golnoosh
authors.initials: G
authors.lastname: Kohi
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Sharekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
keywords: Contrast media; Green tea; Nephrotoxicity; Renal injury