title: Association of gallbladder polyp with the risk of colorectal adenoma.
abstract: OBJECTIVE
  Gallbladder polyps and colorectal adenomas share many common risk factors; however, their association has never been studied. The aim of this study was to investigate this association in asymptomatic healthy subjects.
  
  
  METHODS
  Consecutive asymptomatic subjects who underwent both screening colonoscopy and abdominal ultrasonography at Kyung Hee University Hospital in Gang Dong between July 2010 and April 2011 were prospectively enrolled. The prevalence of colorectal adenoma was compared between subjects with or without gallbladder polyps. Furthermore, a logistic regression analysis was performed to determine the independent risk factors for colorectal adenoma in these subjects.
  
  
  RESULTS
  Of the 581 participants, 55 presented with gallbladder polyps and 526 did not have gallbladder polyps. Participants with gallbladder polyps showed a trend toward a higher prevalence of colorectal adenoma than those without gallbladder polyps (52.7% vs. 39.2%, P=0.051). Although the result was not statistically significant, gallbladder polyps were found to be a possible risk factor for colorectal adenoma (odds ratio=1.796, 95% confidence interval=0.986-3.269, P=0.055), even after adjusting for potential confounding factors. There was no difference observed in colorectal adenoma characteristics between the two groups.
  
  
  CONCLUSIONS
  Our results suggest a possible association between gallbladder polyps and colorectal adenomas. Future studies with larger cohorts are warranted to further investigate this matter.
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Jung Won
authors.initials: JW
authors.lastname: Jeun
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Cha
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Joung Il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Hyun Phil
authors.initials: HP
authors.lastname: Shin
authors.affiliation: Department of Gastroenterology, Kyung Hee University Hospital at Gang Dong, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Jun Uk
authors.initials: JU
authors.lastname: Lim
keywords: Abdominal ultrasonography; Colonoscopy; Colorectal neoplasm; Gallbladder polyp; Mass screening