title: Milk makes lysosomes lethal.
abstract: Stat3 has been shown to regulate lysosome membrane permeabilization and cell death in vivo during post-lactation mammary gland involution. It is now revealed that Stat3 induces lysosome membrane permeabilization by causing phagocytosis of milk fat globules, which destabilize the lysosome membrane leading to leakage of cathepsin proteases.
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA and at Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
authors.forename: Shefali
authors.initials: S
authors.lastname: Krishna
authors.affiliation: Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA and at Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Overholtzer
mesh_terms: D000818:Animals; D005260:Female; D006017:Glycolipids / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D066292:Lipid Droplets; D008247:Lysosomes / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*; D050796:STAT3 Transcription Factor / Q000378:metabolism*
chemical_list: D006017:Glycolipids; D006023:Glycoproteins; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; C110367:milk fat globule