title: The effectiveness of photodynamic therapy on planktonic cells and biofilms and its role in wound healing.
abstract: Photodynamic therapy (PDT) is the application of a photoactive dye followed by irradiation that leads to the death of microbial cells in the presence of oxygen. Its use for controlling biofilms has been documented in many areas, particularly oral care. However, the potential use of PDT in the treatment of chronic wound-associated microbial biofilms has sparked much interest in the field of wound care. The aim of this article is to provide an overview on the effectiveness of PDT on in vitro and in vivo biofilms, their potential application in both the prevention and management of wound biofilm infections and their prospective role in the enhancement of wound healing.
authors.affiliation: Surface Science Research Centre, University of Liverpool, Liverpool. UK.
authors.forename: Steven L
authors.initials: SL
authors.lastname: Percival
authors.forename: Louise
authors.initials: L
authors.lastname: Suleman
authors.forename: Iolanda
authors.initials: I
authors.lastname: Francolini
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Donelli
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000528:radiation effects*; D004195:Disease Models, Animal; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects* / Q000528:radiation effects*; D014946:Wound Infection / Q000628:therapy
chemical_list: D000890:Anti-Infective Agents; D017319:Photosensitizing Agents
keywords: PDT; biofilms; chronic wounds; photodynamic therapy