title: Identifying disease genes by integrating multiple data sources.
abstract: BACKGROUND
  Now multiple types of data are available for identifying disease genes. Those data include gene-disease associations, disease phenotype similarities, protein-protein interactions, pathways, gene expression profiles, etc.. It is believed that integrating different kinds of biological data is an effective method to identify disease genes.
  
  
  RESULTS
  In this paper, we propose a multiple data integration method based on the theory of Markov random field (MRF) and the method of Bayesian analysis for identifying human disease genes. The proposed method is not only flexible in easily incorporating different kinds of data, but also reliable in predicting candidate disease genes.
  
  
  CONCLUSIONS
  Numerical experiments are carried out by integrating known gene-disease associations, protein complexes, protein-protein interactions, pathways and gene expression profiles. Predictions are evaluated by the leave-one-out method. The proposed method achieves an AUC score of 0.743 when integrating all those biological data in our experiments.
authors.forename: Bolin
authors.initials: B
authors.lastname: Chen
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Fang-Xiang
authors.initials: FX
authors.lastname: Wu
mesh_terms: D001499:Bayes Theorem; D019295:Computational Biology / Q000379:methods*; D004194:Disease / Q000235:genetics*; D006801:Humans; D008390:Markov Chains