title: Expression and significance of plasma 3-NT and ox-LDL in patients with Alzheimer's disease.
abstract: To examine the expression and clinical significance of plasma 3-nitrotyrosine (3-NT) and oxidized low-density lipoprotein (ox-LDL) levels in patients with Alzheimer's disease (AD), we examined 48 AD patients and 37 healthy control subjects. The Mini-Mental State Examination, Activities of Daily Living Scale, and Hachinski Ischemic Scale were examined in all subjects. AD patients were classified using the Global Deterioration Scale. The concentrations of plasma 3-NT and ox-LDL were detected using an enzyme-linked immunosorbent assay. We found that the plasma 3-NT concentration in the AD group (119.46 ± 21.82 nM) was significantly higher than that in the control group (55.09 ± 9.63 nM) (P < 0.05). Spearman analysis showed that plasma 3-NT level was negatively associated with the Mini-Mental State Examination results of AD patients. Plasma ox-LDL level in the AD group (112.25 ± 17.81 mg/L) was significantly higher than that in the control group (47.46 ± 10.04 mg/L) (P < 0.05). Spearman analysis showed that plasma ox-LDL level was positively correlated with AD severity in AD patients. However, plasma 3-NT level in the AD group was not associated with plasma ox-LDL level. Therefore, plasma 3-NT and ox-LDL levels in AD patients were significantly increased, which may be related to the degree of AD severity in AD patients.
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China zhaozhong3355@126.com.
authors.forename: Z
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Peng
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: C H
authors.initials: CH
authors.lastname: Qiu
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Q Y
authors.initials: QY
authors.lastname: Sun
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: H N
authors.initials: HN
authors.lastname: Xie
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D015870:Gene Expression; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012720:Severity of Illness Index; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; C002744:3-nitrotyrosine; D014443:Tyrosine