title: Comparative study on the hypoglycemic and antioxidative effects of fermented paste (doenjang) prepared from soybean and brown rice mixed with rice bran or red ginseng marc in mice fed with high fat diet.
abstract: The effects of fermented paste made from soybean, brown rice, or brown rice in combination with rice bran or red ginseng marc on the glucose metabolism and antioxidative defense system in high fat-fed mice were investigated. The mice were given experimental diets for eight weeks: Normal control, high fat, and high fat supplemented with soybean fermented paste, brown rice fermented paste, brown rice-rice bran fermented paste, or brown rice-red ginseng marc fermented paste. The high fat group showed markedly higher blood glucose level and erythrocyte lipid peroxidation than the normal control group. Diet supplementation of fermented paste inhibited the high fat-induced hyperglycemia and oxidative stress via regulation of the glucose-regulating and antioxidant enzymes activities. The soybean and brown rice-red ginseng marc fermented pastes were the most effective in improving the glucose metabolism and antioxidant defense status in mice under high fat diet condition. These findings illustrate that brown rice, in combination with red ginseng marc, may be useful in the development of fermented paste with strong hypoglycemic and antioxidative activities.
authors.affiliation: Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National Universiy, 1370 Sankyuk-ong, Degu 702-701, Korea. zizibe0312@nate.com.
authors.forename: Soo Im
authors.initials: SI
authors.lastname: Chung
authors.affiliation: Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National Universiy, 1370 Sankyuk-ong, Degu 702-701, Korea. ckwrico@gmail.com.
authors.forename: Catherine W
authors.initials: CW
authors.lastname: Rico
authors.affiliation: Department of Food Science and Nutrition, Brain Korea 21 Plus, Kyungpook National Universiy, 1370 Sankyuk-ong, Degu 702-701, Korea. makang@knu.ac.kr.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Kang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D001786:Blood Glucose / Q000187:drug effects*; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D004912:Erythrocytes / Q000378:metabolism; D005285:Fermentation; D005502:Food; D006943:Hyperglycemia / Q000178:diet therapy* / Q000209:etiology / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D012275:Oryza; D005894:Panax; D008517:Phytotherapy / Q000379:methods*; D045730:Soy Foods; D013025:Glycine max; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D001786:Blood Glucose