title: miR-219 inhibits the growth and metastasis of TSCC cells by targeting PRKCI.
abstract: Tongue squamous cells carcinoma (TSCC) is the most common type in oral cancers. Recently, accumulating evidence suggests that microRNAs (miRNAs) play critical roles in tumorigenesis. Here, we demonstrated that miR-219 was significantly downregulated in TSCC tissues and cell lines. miR-219 overexpression remarkably suppressed cell proliferation, colony formation, migration and invasion of TSCC cells. In addition, protein kinase CI (PRKCI) was identified as a target of miR-219, and overexpression of PRKCI could significantly attenuated the tumor suppressive effects of miR-219. Furthermore, PRKCI inversely correlates with miR-219 in TSCC tissues. Taken together, miR-219 inhibited growth and metastasis by targeting PRKCI and might be used as a potential target for the treatment of TSCC.
authors.affiliation: Department of Head and Neck Surgery, Third Affiliated Hospital of Harbin Medical University Harbin 150081, Heilongjiang, China.
authors.forename: Kai-Bin
authors.initials: KB
authors.lastname: Song
authors.affiliation: Department of Neurology, The Second Affiliated Hospital of Harbin Medical University Harbin 150001, Heilongjiang, China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Liu
authors.affiliation: Department of Head and Neck Surgery, Third Affiliated Hospital of Harbin Medical University Harbin 150081, Heilongjiang, China.
authors.forename: Shen-Shan
authors.initials: SS
authors.lastname: Jia
keywords: PRKCI; TSCC; growth; metastasis; miR-219