title: SPRTN is a new player in an old story.
abstract: A new study identifies rare mutations in SPRTN that cause a novel progeroid syndrome. The results point to an unexpected function of SPRTN and bring insight to the mechanisms that link premature aging and cancer.
authors.affiliation: Ninewells Medical School and Hospital, University of Dundee, Dundee, UK.
authors.forename: Kevin
authors.initials: K
authors.lastname: Hiom
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D011371:Progeria / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; C574636:SPRTN protein, human