title: A temporary-bridge strategy for enantioselective organocatalyzed synthesis of aza-seven-membered rings.
abstract: We report the first enantioselective organocatalyzed domino synthesis of azepane moieties. This temporary-bridge strategy is based on a conceptually original annulation of ambident electrophilic and 1,4-bis-nucleophilic α-ketoamides with 1,3-bis-electrophilic enals. The obtained oxygen-bridged azepanes can be selectively transformed into optically active azepanone, azepanol or azepanedione derivatives of high synthetic value.
authors.affiliation: Aix Marseille Université, CNRS, Centrale Marseille, ISM2 UMR 7313, 13397, Marseille, France. damien.bonne@univ-amu.fr jean.rodriguez@univ-amu.fr.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Goudedranche
authors.forename: David
authors.initials: D
authors.lastname: Pierrot
authors.forename: Thierry
authors.initials: T
authors.lastname: Constantieux
authors.forename: Damien
authors.initials: D
authors.lastname: Bonne
authors.forename: Jean
authors.initials: J
authors.lastname: Rodriguez