title: Ki-67 and p53 expression in solitary sporadic, syndrome associated and recurrent keratocystic odontogenic tumor.
abstract: BACKGROUND
  Ki-67 and p53 are markers expressed in actively proliferating cells, particularly in neoplasms.
  
  
  OBJECTIVE
  (1) To study the proliferative potential of epithelia in Solitary Sporadic, Syndrome-associated and Recurrent Keratocystic odontogenic tumors (KCOTs) using Ki67 and p53 labeling indices (LI). (2) To derive a relationship if any between the expression of these proteins and the biologic behavior of Solitary Sporadic and Syndrome associated KCOTs.
  
  
  METHODS
  Thirteen paraffin embedded blocks of KCOTs (Solitary Sporadic, n = 03; Recurrent, n = 03; Syndrome associated, n = 07) were stained immunohistochemically for Ki-67 and p53 and labeling indices were calculated.
  
  
  METHODS
  Z test with predetermined alpha set at 0.05 was used for the comparison of Ki-67 positivity between the three groups and p53 positivity between the three groups.
  
  
  RESULTS
  Ki-67 labeling indices were: 30% in solitary sporadic; 26% in recurrent; and 32% in syndrome associated KCOTs. p53 labeling indices were: 19% in solitary sporadic; 23% in recurrent; and 21% in syndrome-associated KCOTs. There was no difference seen in the rate of proliferation in the epithelial linings between the three groups. However, in our cases where Ki-67 positivity was seen there was expression of p53. Though not statistically significant a trend was seen, reflecting the loss of balance between the proliferative potential and apoptotic activity.
  
  
  CONCLUSIONS
  On the basis of proliferative index alone it is not possible to comment on biological behavior of KCOTs associated with syndrome versus those of solitary and recurrent. There is probably a mesenchymal role which needs to be researched.
authors.affiliation: Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Karnataka, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Alur
authors.affiliation: Impression Dental Care, No 102, Elegant Desire, Coles Road, Frazer Town, Bangalore, Karnataka, India.
authors.forename: T V
authors.initials: TV
authors.lastname: Narayan
authors.affiliation: Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Karnataka, India.
authors.forename: Leeky
authors.initials: L
authors.lastname: Mohanty
authors.affiliation: Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Karnataka, India.
authors.forename: Sadhana
authors.initials: S
authors.lastname: Shenoy
authors.affiliation: Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Karnataka, India.
authors.forename: Saleha
authors.initials: S
authors.lastname: Jamadar
authors.affiliation: Department of Oral Pathology and Microbiology, The Oxford Dental College, Hospital and Research Centre, Karnataka, India.
authors.forename: Shobith
authors.initials: S
authors.lastname: Shetty
keywords: Ki-67; keratocystic odontogenic tumor; nevoid basal cell carcinoma syndrome; p53