title: Plasma exchanges and immunosuppression for anti-complement factor H associated hemolytic uremic syndrome.
abstract: BACKGROUND
  Atypical hemolytic uremic syndrome associated with autoantibodies to complement factor H is an important cause of acute kidney injury; most patients require dialysis and are at risk of progressive renal failure.
  
  
  METHODS
  7 patients with gastrointestinal symptoms, acute kidney injury, thrombotic microangiopathy and elevated levels of anti-complement factor H antibodies.
  
  
  METHODS
  Prompt initiation of plasma exchanges and immunosuppression.
  
  
  RESULTS
  Remission of hematological and kidney functions.
  
  
  CONCLUSIONS
  Prompt and specific management of antibody associated hemolytic uremic syndrome is associated with favorable outcome.
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, AIIMS, New Delhi, India. Correspondence to: Dr Arvind Bagga, Division of Pediatric Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India. arvindbagga@hotmail.com.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Khandelwal
authors.forename: Aditi
authors.initials: A
authors.lastname: Sinha
authors.forename: Pankaj
authors.initials: P
authors.lastname: Hari
authors.forename: Arvind
authors.initials: A
authors.lastname: Bagga
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001323:Autoantibodies; D002648:Child; D002675:Child, Preschool; D017242:Complement Factor H / Q000037:antagonists & inhibitors; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000628:therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic; D008297:Male; D010951:Plasma Exchange
chemical_list: D000305:Adrenal Cortex Hormones; D001323:Autoantibodies; D007166:Immunosuppressive Agents; D017242:Complement Factor H