title: Practical guidelines for diagnosing hypersensitivity reactions to nonsteroidal anti-inflammatory drugs.
abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most frequently involved in hypersensitivity reactions. These reactions include various clinical entities with different mechanisms leading to the release of inflammatory mediators. Characterization of patients based on clinical manifestations and suspected underlying mechanisms is critical for implementation of adequate diagnostic procedures and patient management. Our objectives were to prepare a systematic review of available scientific evidence and to provide general guidelines for the diagnosis and management of patients with hypersensitivity reactions to NSAIDs. We also propose a practical algorithm for the diagnosis of specific types of hypersensitivity to NSAIDs and provide recommendations for the management of hypersensitive patients.
authors.forename: N
authors.initials: N
authors.lastname: Ortega
authors.forename: I
authors.initials: I
authors.lastname: Doña
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: M T
authors.initials: MT
authors.lastname: Audicana
authors.forename: M J
authors.initials: MJ
authors.lastname: Barasona
authors.forename: M P
authors.initials: MP
authors.lastname: Berges-Gimeno
authors.forename: N
authors.initials: N
authors.lastname: Blanca-Lopez
authors.forename: T
authors.initials: T
authors.lastname: Lobera
authors.forename: A
authors.initials: A
authors.lastname: Padial
authors.forename: A
authors.initials: A
authors.lastname: Rosado
authors.forename: M J
authors.initials: MJ
authors.lastname: Torres
mesh_terms: D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D017410:Practice Guidelines as Topic; D012882:Skin Tests
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal