title: Of microspheres and microbes: A double-hit strategy for cancer immunotherapy.
abstract: Efficient immunotherapy relies on the rapid generation of elevated amounts of cancer-specific T lymphocytes. We have recently demonstrated that both rapid and potent tumor-targeting immune responses can be induced with a heterologous prime-boost regimen consisting of poly-lactic co-glycolic acid (PLGA) microsphere-based immunization followed byListeria monocytogenesinfection.
authors.affiliation: Department of Gastroenterology, Hepatology and Endocrinology; Medical School Hannover; Hannover, Germany.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brinkhoff
authors.affiliation: Department of Gastroenterology, Hepatology and Endocrinology; Medical School Hannover; Hannover, Germany.
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wirth
keywords: CD8 T cells; Listeria; liver cancer; microspheres; vaccination