title: Conservative growth hormone/IGF-1 and mTOR signaling pathways as a target for aging and cancer prevention: do we really have an antiaging drug?
abstract: Inactivation of the GH/insulin/IGF-1 signaling molecules corresponding genes as well as the inactivation of serine/threonine protein kinase mTOR increases life span in nematodes, fruit flies and mice. Evidence has emerged that antidiabetic biguanides and rapamycin are promising candidates for pharmacological interventions leading to both life span extension and prevention of cancer. The available data on the relationship of two fundamental processes--aging and carcinogenesis--have been suggested to be a basis for understanding these two-side effects of biguanides and rapamycin.
authors.affiliation: Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008136:Longevity; D009369:Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*
chemical_list: D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases