title: Arterial spin labeling to determine tumor viability in head and neck cancer before and after treatment.
abstract: OBJECTIVE
  To evaluate the feasibility of arterial spin-labeling (ASL) in head and neck cancer for noninvasive measurement of tumor blood flow (TBF), by comparing 1) the TBF change before and after the treatment, and 2) posttreatment TBF and its reduction rate between residual and nonresidual tumors after treatment.
  
  
  METHODS
  Twenty-two patients with head and neck cancer were evaluated using ASL on 3.0-T magnetic resonance imaging (MRI) before and after nonsurgical treatment. A pulsed ASL sequence with Look–Locker readout was used to calculate quantitative TBF. TBF reduction rates between pre- and posttreatment values were also calculated. Residual tumors were confirmed when present with either histopathologically or clinical follow-up.
  
  
  RESULTS
  Pre- and posttreatment mean TBF values were 121.4 ± 27.8 (standard deviation) and 24.9 ± 14.9 mL/100g/min, respectively. Pre- and posttreatment TBF differed significantly. Posttreatment TBF was significantly higher in patients with residual tumors (five patients, 46.9 ± 7.1 mL/100g/min) than in those without (17 patients, 18.4 ± 9.2 mL/100g/min). The TBF reduction rate was significantly lower in patients with residual tumors (0.540.55 ± 0.120.12) than in those without (0.85 ± 0.06).
  
  
  CONCLUSIONS
  ASL allows quantitative assessment of TBF in head and neck cancer. ASL may be useful for noninvasive assessment of tumor viability in head and neck cancer.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fujima
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakashita
authors.forename: Akiko
authors.initials: A
authors.lastname: Tsukahara
authors.lastname: Khin Khin Tha
authors.lastname: Yuri Zaitsu
authors.lastname: Satoshi Terae
authors.lastname: Hiroki Shirato
mesh_terms: D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D013113:Spin Labels; D016896:Treatment Outcome
chemical_list: D013113:Spin Labels