title: Codonopsis lanceolata extract prevents diet-induced obesity in C57BL/6 mice.
abstract: Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice.
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. jongseoklee78@gmail.com.
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20742, USA. kjkim@umd.edu.
authors.forename: Kui-Jin
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. vvkyh@naver.com.
authors.forename: Young-Hyun
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. danbekim22@nate.com.
authors.forename: Dan-Bi
authors.initials: DB
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. cordelia162@hanmail.net.
authors.forename: Gi-Hae
authors.initials: GH
authors.lastname: Shin
authors.affiliation: Hurum Central Research Institute, Ochang 363-883, Korea. dusvnd608@hurum.co.kr.
authors.forename: Ju-Hyun
authors.initials: JH
authors.lastname: Cho
authors.affiliation: Hurum Central Research Institute, Ochang 363-883, Korea. kp2307@hurum.co.kr.
authors.forename: Bong Kyun
authors.initials: BK
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, CHA University, Seongnam 463-836, Korea. bylee@cha.ac.kr.
authors.forename: Boo-Yong
authors.initials: BY
authors.lastname: Lee
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea. loh99@kangwon.ac.kr.
authors.forename: Ok-Hwan
authors.initials: OH
authors.lastname: Lee
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D019440:Anti-Obesity Agents / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D029745:Codonopsis / Q000737:chemistry*; D059305:Diet, High-Fat; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D050507:Subcutaneous Fat, Abdominal / Q000187:drug effects / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D019440:Anti-Obesity Agents; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase