title: The role of dynamic instability in microtubule organization.
abstract: Microtubules are one of the three major cytoskeletal components in eukaryotic cells. Heterodimers composed of GTP-bound α- and β-tubulin molecules polymerize to form microtubule protofilaments, which associate laterally to form a hollow microtubule. Tubulin has GTPase activity and the GTP molecules associated with β-tubulin molecules are hydrolyzed shortly after being incorporated into the polymerizing microtubules. GTP hydrolysis alters the conformation of the tubulin molecules and drives the dynamic behavior of microtubules. Periods of rapid microtubule polymerization alternate with periods of shrinkage in a process known as dynamic instability. In plants, dynamic instability plays a key role in determining the organization of microtubules into arrays, and these arrays vary throughout the cell cycle. In this review, we describe the mechanisms that regulate microtubule dynamics and underlie dynamic instability, and discuss how dynamic instability may shape microtubule organization in plant cells.
authors.affiliation: Department of Natural Sciences, Nippon Sport Science University Yokohama, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Horio
authors.affiliation: Division of Evolutionary Biology, National Institute for Basic Biology Okazaki, Japan ; Department of Basic Biology, School of Life Sciences, The Graduate University for Advanced Studies Okazaki, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Murata
keywords: GTP hydrolysis; cortical array; dynamic instability; microtubule; phragmoplast; tubulin