title: Advances in metal-catalyzed cross-coupling reactions of halogenated quinazolinones and their quinazoline derivatives.
abstract: Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon-carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview of the application of these methods on halogenated quinazolin-4-ones and their quinazolines to generate novel polysubstituted derivatives.
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. mphahmj@unisa.ac.za.
authors.forename: Malose Jack
authors.initials: MJ
authors.lastname: Mphahlele
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. malulmm@unisa.ac.za.
authors.forename: Marole Maria
authors.initials: MM
authors.lastname: Maluleka
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D054879:Halogenation; D006219:Halogens / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D011799:Quinazolines / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry*
chemical_list: D006219:Halogens; D008670:Metals; D011799:Quinazolines; D052999:Quinazolinones; D002244:Carbon