title: Histological changes in nontumoral liver secondary to radioembolization of hepatocellular carcinoma with yttrium 90-impregnated microspheres: report of two cases.
abstract: Transarterial radioembolization (TARE) with yttrium-90 is a minimally invasive locoregional therapy for hepatocellular carcinoma (HCC), and involves selective delivery of glass or resin microspheres impregnated with radioactive yttrium-90 into small arteries preferentially supplying the tumor for tumoricidal effect thus sparing the nontumoral liver, or into lobar artery to induce atrophy and contralateral hypertrophy. Clinically, post-TARE a small proportion of cases develop radioembolization-induced liver disease. Histological changes of TARE on nontumoral liver parenchyma have not been well characterized. Herein, we report two cases of liver resections for HCC post-TARE, and describe the histological changes in nontumoral liver parenchyma.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center, Houston, Texas.
authors.forename: Sadhna
authors.initials: S
authors.lastname: Dhingra
authors.affiliation: Recanati-Miller Transplantation Institute, Mount Sinai Health System, New York, New York.
authors.forename: Myron
authors.initials: M
authors.lastname: Schwartz
authors.affiliation: Department of Vascular and Interventional Radiology, Mount Sinai Health System, New York, New York.
authors.forename: Edward
authors.initials: E
authors.lastname: Kim
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
authors.forename: Huaibin
authors.initials: H
authors.lastname: Mabel Ko
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Ward
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Fiel
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai Health System, New York, New York.
authors.forename: Swan N
authors.initials: SN
authors.lastname: Thung
mesh_terms: D000328:Adult; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000532:radiotherapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D008099:Liver / Q000473:pathology / Q000528:radiation effects*; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology*; D008113:Liver Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D011237:Predictive Value of Tests; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000009:adverse effects*; D012307:Risk Factors; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes