title: Early pulmonary involvement of anti-CADM-140 autoantibody-positive rapidly progressive interstitial lung disease preceding typical cutaneous symptoms.
abstract: We herein report a patient with clinically amyopathic dermatomyositis (CADM) who developed anti-CADM-140 autoantibody in association with rapidly progressive interstitial lung disease (RP-ILD). Chest high-resolution computed tomography (HRCT) revealed early pulmonary involvement preceding typical cutaneous lesions. Primary lesions of patchy peribronchial opacity developed ground-glass opacity and consolidation with architectural distortion and traction bronchiectasis. The possibility of anti-CADM-140 autoantibody-associated RP-ILD should be considered when patchy peribronchial opacity of an unknown cause is visible on chest HRCT.
authors.affiliation: Department of Respiratory Medicine, Kobe City Medical Center General Hospital, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Tamai
authors.forename: Ryo
authors.initials: R
authors.lastname: Tachikawa
authors.forename: Kyoko
authors.initials: K
authors.lastname: Otsuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ueda
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hosono
authors.forename: Keisuke
authors.initials: K
authors.lastname: Tomii
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D003882:Dermatomyositis / Q000097:blood / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D010455:Peptides / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C501597:CADM-140 peptide, human; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides