title: Expression of p53, Ki67, epidermal growth factor receptor, transforming growth-factorα, and p21 in primary and secondary hyperparathyroidism.
abstract: BACKGROUND
  Secondary hyperparathyroidism (SH) is major problem in chronic renal failure. There are studies to examine proliferation and apoptosis associated biomarkers expressions in parathyroid lesions to reveal specific features. In this study, we evaluated the expression of some growth factors and their receptors in parathyroid gland of patients with SH or primary hyperparathyroidism (PH).
  
  
  METHODS
  A total of 49 patients had been operated for PH and 26 for SH. Parathyroid tissue samples were evaluated histopathologically and immunohistochemically using antibodies to human p53, Kİ-67, anti-human p21, antitransforming growth factor (TGF) α, CPP32 (caspase 3), and epidermal growth factor receptor (EGFR).
  
  
  RESULTS
  Adenoma was higher in PH compared with SH as 48/49 and 3/26, respectively (P = 0.000). Parathyroid hyperplasia was found in 23/26 patients with SH and 1/49 patient with PH. In parathyroid tissue there were no difference between PH and SH for p53, Ki-67, caspase, EGFR expressions; while there were significantly difference for TGFα (P = 0.047) and borderline significant difference for p21 (P = 0.06) expressions.
  
  
  CONCLUSIONS
  Adenoma was priority present in PH patients, hyperplasia was present in SH. There were no differences between primary and SH or adenoma and hyperplasia for expressions of cycline-dependent kinase inhibitor p21, p53, EGFR, Ki67, caspase; while TGFα expression was found to be different.
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Saime
authors.initials: S
authors.lastname: Paydas
authors.affiliation: Department of Pathology and General Surgery, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Arbil
authors.initials: A
authors.lastname: Acikalim
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Bulent
authors.initials: B
authors.lastname: Kaya
authors.affiliation: Department of Pathology and General Surgery, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Bermal Hasbay
authors.initials: BH
authors.lastname: Bicer
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ulker
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Demircan
authors.affiliation: Department of Pathology and General Surgery, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Uguz
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Balal
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Gurhan
authors.initials: G
authors.lastname: Sakman
authors.affiliation: Department of Biostatistics, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Yasar
authors.initials: Y
authors.lastname: Sertdemir
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Refika
authors.initials: R
authors.lastname: Karaer
authors.affiliation: Department of Nephrology, Faculty of Medicine, Cukurova University, Adana, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Altun
keywords: EGFR; Ki67; TGFα; hyperparathyroidism; p21; p21 hyperparathyroidism; p53