title: Primary intravascular large B-cell lymphoma of the lung: a review and case report.
abstract: OBJECTIVE
  To investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung.
  
  
  METHODS
  Histopathological and clinical data based on lung biopsy were analyzed and used to diagnose a patient with IVLBCL of the lung.
  
  
  RESULTS
  Fever and respiratory symptoms were the main presentations, lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed Bcl-2, the Bcl-6, CD20, Ki67, MUM-1, Pax5, CD, CD30, and vascular endothelial CD34.
  
  
  CONCLUSIONS
  Primary pulmonary IVLBCL of the lung is extremely rare, on chest CT it manifests as diffuse ground glass shadow, or nodular consolidations in the lung, lactate dehydrogenase and C-reactive protein was found to increase, fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is an important and significant diagnostic modality in its early diagnosis. Also, bronchial lung biopsy has the advantage of less trauma and high sensitive rate. R-CHOP is the main treatment for lung primary pulmonary IVLBCL of the lung; however, its prognosis is relatively poor.
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Yanfan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ding
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Lin
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Kaiyan
authors.initials: K
authors.lastname: Yang
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Yuping
authors.initials: Y
authors.lastname: Li
authors.affiliation: 1 Department of Respiration, Zhejiang Chinese Medical University, Hangzhou 310000, China ; 2 Department of Respiration, 3 Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
authors.forename: Shaoxian
authors.initials: S
authors.lastname: Chen
keywords: Intravascular lymphoma; case report; large B-cell; lung