title: Neuropsychological and brain volume differences in patients with left- and right-beginning corticobasal syndrome.
abstract: BACKGROUND
  Corticobasal Syndrome (CBS) is a rare neurodegenerative syndrome characterized by unilaterally beginning frontoparietal and basal ganglia atrophy. The study aimed to prove the hypothesis that there are differences in hemispheric susceptibility to disease-related changes.
  
  
  METHODS
  Two groups of CBS patients with symptoms starting either on the left or right body side were investigated. Groups consisted of four patients each and were matched for sex, age and disease duration. Patient groups and a group of eight healthy age-matched controls were analyzed using deformation field morphometry and neuropsychological testing. To further characterize individual disease progression regarding brain atrophy and neuropsychological performance, two female, disease duration-matched patients differing in initially impaired body side were followed over six months.
  
  
  RESULTS
  A distinct pattern of neural atrophy and neuropsychological performance was revealed for both CBS: Patients with initial right-sided impairment (r-CBS) revealed atrophy predominantly in frontoparietal areas and showed, except from apraxia, no other cognitive deficits. In contrast, patients with impairment of the left body side (l-CBS) revealed more widespread atrophy, extending from frontoparietal to orbitofrontal and temporal regions; and apraxia, perceptional and memory deficits could be found. A similar pattern of morphological and neuropsychological differences was found for the individual disease progression in l-CBS and r-CBS single cases.
  
  
  CONCLUSIONS
  For similar durations of disease, volumetric grey matter loss related to CBS pathology appeared earlier and progressed faster in l-CBS than in r-CBS. Cognitive impairment in r-CBS was characterized by apraxia, and additional memory and perceptional deficits for l-CBS.
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Jütten
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Pieperhoff
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Südmeyer
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schleicher
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrea
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Caspers
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; JARA-Brain, Jülich-Aachen Research Alliance, Jülich, Germany; Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany.
authors.forename: Karl
authors.initials: K
authors.lastname: Zilles
authors.affiliation: Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: Alfons
authors.initials: A
authors.lastname: Schnitzler
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany; C. & O. Vogt Institute for Brain Research, Heinrich Heine University, Düsseldorf, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Amunts
authors.affiliation: Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Lux
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000473:pathology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D066128:Gray Matter / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology; D013577:Syndrome