title: Integral indicator of oxidative stress in human blood.
abstract: Here we performed individual evaluation of the oxidative stress index that serves as an integral criterion for the balance of LPO-antioxidant defense system in women with endocrine pathology (type 1 diabetes mellitus and infertility with hyperprolactinemia). The state of the LPO-antioxidant defense system was estimated from blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes, conjugated trienes, thiobarbituric acid-reactive substances, retinol, α-tocopherol, reduced and oxidized glutathione, and SOD activity. The use of this oxidative stress index allowed us to diagnose oxidative stress in female patients with endocrine pathology.
authors.affiliation: Research Center for Problems of Family Health and Human Reproduction, Siberian Division of the Russian Academy of Medical Sciences, Irkutsk, Russia.
authors.forename: L I
authors.initials: LI
authors.lastname: Kolesnikova
authors.forename: N V
authors.initials: NV
authors.lastname: Semyonova
authors.forename: L A
authors.initials: LA
authors.lastname: Grebenkina
authors.forename: M A
authors.initials: MA
authors.lastname: Darenskaya
authors.forename: L V
authors.initials: LV
authors.lastname: Suturina
authors.forename: S V
authors.initials: SV
authors.lastname: Gnusina
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D007247:Infertility, Female / Q000097:blood*; D015227:Lipid Peroxidation / Q000276:immunology; D018384:Oxidative Stress / Q000502:physiology*; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances; D014801:Vitamin A / Q000097:blood; D024502:alpha-Tocopherol / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017392:Thiobarbituric Acid Reactive Substances; D014801:Vitamin A; D013482:Superoxide Dismutase; D005978:Glutathione; D024502:alpha-Tocopherol