title: Anti-wrinkle effects of fermented and non-fermented Cyclopia intermedia in hairless mice.
abstract: BACKGROUND
  The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects. Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin.
  
  
  METHODS
  The inhibitory effects of honeybush extract and fermented honeybush on wrinkle formation were determined by analyzing skin replicas, histologically examining epidermal thickness, and identifying damage to collagen fibers.
  
  
  RESULTS
  Honeybush extract and fermented honeybush reduced the length and depth of skin winkles caused by UV irradiation and inhibited thickening of the epidermal layer, in addition to suppressing collagen tissue breakdown reactions, indicating its potential use as a skin wrinkle prevention agent.
  
  
  CONCLUSIONS
  This in vivo study demonstrates that honeybush produces significant anti-wrinkle effects and is therefore of interest in anti-aging skin care products.
authors.forename: A-Rang
authors.initials: AR
authors.lastname: Im
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Song
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Sung Hum
authors.initials: SH
authors.lastname: Yeon
authors.forename: Key An
authors.initials: KA
authors.lastname: Um
authors.affiliation: KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 305-811, Korea. kendall@kiom.re.kr.
authors.forename: Sungwook
authors.initials: S
authors.lastname: Chae
mesh_terms: D000818:Animals; D004817:Epidermis / Q000187:drug effects / Q000528:radiation effects; D007887:Fabaceae / Q000737:chemistry* / Q000382:microbiology; D005285:Fermentation; D006801:Humans; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010936:Plant Extracts / Q000008:administration & dosage* / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D048249:Streptococcus thermophilus / Q000378:metabolism; D013473:Sunscreening Agents / Q000008:administration & dosage* / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D010936:Plant Extracts; D013473:Sunscreening Agents