title: Serum YKL-40 for monitoring myocardial ischemia after revascularization in patients with stable coronary artery disease.
abstract: OBJECTIVE
  The aim was to investigate the inflammatory biomarker YKL-40 as a monitor of myocardial ischemia in patients with coronary artery disease (CAD).
  
  
  METHODS
  A total of 311 patients with stable CAD were included. Blood samples were taken at baseline, the day after coronary angiography and/or after percutaneous coronary intervention and after 6 months.
  
  
  RESULTS
  A total of 148 (48%) patients were revascularized and 163 patients underwent only coronary angiography. In the entire population, serum YKL-40 increased significantly from baseline to 6 months (p = 0.05). This tendency was seen in nonrevascularized patients (p = 0.06), but not in revascularized patients (p = 0.46). Serum YKL-40 increased approximately 25% the day after the invasive procedure (p < 0.001) and then decreased significantly to nearly baseline after 6 months (p = 0.002).
  
  
  CONCLUSIONS
  Serum YKL-40 is a potential promising biomarker of disease progression but not of myocardial ischemia in patients with stable CAD.
authors.affiliation: Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital & Faculty of Health Sciences, Copenhagen, Denmark.
authors.forename: Marina
authors.initials: M
authors.lastname: Harutyunyan
authors.forename: Julia S
authors.initials: JS
authors.lastname: Johansen
authors.forename: Naja D
authors.initials: ND
authors.lastname: Mygind
authors.forename: Simon B
authors.initials: SB
authors.lastname: Reuter
authors.forename: Jens
authors.initials: J
authors.lastname: Kastrup
mesh_terms: D054392:Adipokines / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D000071451:Chitinase-3-Like Protein 1; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications* / Q000628:therapy; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006133:Growth Substances / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D009204:Myocardial Revascularization / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006133:Growth Substances; D037102:Lectins
keywords: Biomarker; YKL-40; coronary artery disease; inflammation; ischemia