title: An HIV-1 transmission case possibly associated with manicure care.
abstract: A recently diagnosed 22-year-old female with no history of transmission risk factors prompted a thorough investigation of possible alternative risk factors. As the patient had evidence of advanced disease and laboratory data compatible with long-standing infection, past events were reviewed. About 10 years ago the patient shared manicure utensils with an older cousin, later known to be HIV infected; this prompted the phylogenetic analysis of the HIV sequences of both patients. Phylogenetic analyses of partial HIV-1 polymerase and envelope sequences from both patients revealed highly related sequences, with an estimated common ancestor date (about 11 years ago) that coincided with the putative sharing of manicure instruments, during a time in which the cousin was not virally suppressed. Taken together, the information about the infection of this patient suggests the use of shared manicure instruments as an alternative route of fomite HIV-1 transmission.
authors.affiliation: 1 Santo André Aids Program , São Paulo, SP, Brazil .
authors.forename: Elaine Monteiro
authors.initials: EM
authors.lastname: Matsuda
authors.forename: Luana Portes Ozório
authors.initials: LP
authors.lastname: Coelho
authors.forename: Victor Figueiredo
authors.initials: VF
authors.lastname: Pimentel
authors.forename: Humberto Barjud
authors.initials: HB
authors.lastname: Onias
authors.forename: Luís Fernando de Macedo
authors.initials: LF
authors.lastname: Brigido
mesh_terms: D016000:Cluster Analysis; D003357:Cosmetic Techniques / Q000009:adverse effects*; D018562:Disease Transmission, Infectious; D005260:Female; D015658:HIV Infections / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D063373:Hand Hygiene / Q000379:methods; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D055815:Young Adult; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics
chemical_list: D054299:env Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus