title: CYP1A1 Ile462Val polymorphism and the risk of non-small cell lung cancer in a Chinese population.
abstract: OBJECTIVE
  Cytochrome P450 (CYP) 1A1 enzyme plays an important role in the metabolism of carcinogens, such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines.
  
  
  METHODS
  The study examined the association of CYP1A1 Ile462Val polymorphism with the risk of developing non-small cell lung cancer in a Chinese population. We conducted a case-control study including 526 non-small cell lung cancer cases and 526 cancer-free controls. The odds ratios and 95％ confidence intervals were calculated by logistic regression models.
  
  
  RESULTS
  Compared with 462Ile/Ile genotype carriers, subjects with CYP1A1 462Ile/Val or Val/Val genotype had a decreased risk of developing non-small cell lung cancer with odds ratios of 0.57 (95% CI, 0.44-0.75) and 0.54 (95% CI, 0.36-0.81), respectively. When stratified by smoking status, the decreased risk of non-small cell lung cancer associated with CYP1A1 462Ile/Val or Val/Val genotype was observed among non-smokers (OR = 0.62, 95% CI, 0.45-0.87) and among smokers (OR = 0.54, 95% CI, 0.37-0.78). When stratified by smoking-dose, the correlation between CYP1A1 genotypes and the risk of non-small cell lung cancer was detected among light smokers (OR = 0.30, 95% CI, 0.19-0.48) but not among heavy smokers (OR = 0.93, 95% CI, 0.61-1.43).
  
  
  CONCLUSIONS
  The CYP1A1 Ile462Val variant was associated with a low risk of developing non-small cell lung cancer in a Chinese population.
authors.forename: Jia
authors.initials: J
authors.lastname: Lin
authors.forename: Bing
authors.initials: B
authors.lastname: He
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Zhi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Rao
authors.forename: Yingwen
authors.initials: Y
authors.lastname: Liu
authors.forename: Shasha
authors.initials: S
authors.lastname: Shao
authors.forename: Guangxia
authors.initials: G
authors.lastname: Wang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D017422:Sequence Analysis, DNA; D012907:Smoking / Q000009:adverse effects
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1