title: [Immunopathology of multiple sclerosis].
abstract: Multiple sclerosis is an inflammatory demyelinating disease affecting the central nervous system and considered one of the leading causes of disability in young adults. The precise cause of multiple sclerosis is unknown, although the current evidence points towards a combination of genetic and environmental factors leading to an autoimmune response that promotes neuronal degeneration. In this review, we will describe the association between the immune response and neurodegeneration in multiple sclerosis.
authors.affiliation: Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA. E-mail: fquintana@rics.bwh.harvard.edu.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Quintana
authors.forename: Soledad
authors.initials: S
authors.lastname: Pérez-Sánchez
authors.forename: Mauricio F
authors.initials: MF
authors.lastname: Farez
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D009186:Myelin Sheath / Q000276:immunology; D009410:Nerve Degeneration / Q000276:immunology*; D019636:Neurodegenerative Diseases / Q000276:immunology; D009457:Neuroglia / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
keywords: multiple sclerosis; pathogenesis