title: Use of cyanoacrylate adhesives in general surgery.
abstract: This paper presents a review of the use of cyanoacrylate adhesives (CA) in general surgery and digestive surgery, studies the mechanisms of action and interactions of CAs in adherent tissues, and compiles data on the latest experimental and clinical applications. More than seven million traumatic injuries are estimated to occur every year, and between 26 and 90 million surgical procedures using different techniques are performed to close the resulting wounds. Traditional methods not only are both useful and effective, but also have some drawbacks. This review covers a considerable number of surgical procedures for which CAs had satisfactory results. The adhesive facilitated the healing of very diverse tissues, such as solid organs, vascular tissue or the abdominal wall. In other cases, no significant differences were found when CA was compared to traditional methods, with the adhesive standing out as a simple and reliable solution. The number of procedures in which CA was detrimental was very low. This review also collects and describes these. In conclusion, the surgical fields and procedures in which CA was successfully used are highly diverse. This review will allow physicians to determine which techniques were first used experimentally, but finally settled in clinical practice as feasible alternatives to standard treatments.
authors.affiliation: Experimental Surgery, Universidad Católica de Valencia, C/Quevedo 2, 46001, Valencia, Spain, daviefh@hotmail.com.
authors.forename: David
authors.initials: D
authors.lastname: García Cerdá
authors.forename: Antonio Martín
authors.initials: AM
authors.lastname: Ballester
authors.forename: Alicia
authors.initials: A
authors.lastname: Aliena-Valero
authors.forename: Anna
authors.initials: A
authors.lastname: Carabén-Redaño
authors.forename: José M
authors.initials: JM
authors.lastname: Lloris
mesh_terms: D003487:Cyanoacrylates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013505:Digestive System Surgical Procedures / Q000379:methods; D004621:Embolization, Therapeutic; D004659:Enbucrilate; D006490:Hemostatics; D059685:Herniorrhaphy; D006801:Humans; D010535:Laparoscopy; D013514:Surgical Procedures, Operative / Q000379:methods*; D014014:Tissue Adhesives / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014648:Varicose Veins / Q000628:therapy; D014656:Vascular Surgical Procedures / Q000379:methods; D058106:Wound Closure Techniques; D014945:Wound Healing; D014947:Wounds and Injuries / Q000601:surgery
chemical_list: D003487:Cyanoacrylates; D006490:Hemostatics; D014014:Tissue Adhesives; D004659:Enbucrilate