title: New 19-oxygenated steroid from the South China Sea gorgonian Dichotella gemmacea.
abstract: A new 19-oxygenated steroid, 25-acetate-nebrosteroid K (1), and five known steroids (2-6), along with one known 19-hydroxy steroidal glycoside (7) were obtained from the gorgonian Dichotella gemmacea collected from the South China Sea. The structure and relative configuration of 1 were elucidated by using comprehensive spectroscopic data including NOESY spectra. Compound 1 represents the first example of 19-oxygenated steroid with a 19-oic acid methyl ester group isolated from gorgonians. All of the isolated compounds were evaluated for lethal activity to brine shrimp Artemia salina and cytotoxicity against A549 and HL-60 cell lines. Among them, 1 showed strong lethality towards A. salina.
authors.affiliation: a Key Laboratory of Marine Drugs, The Ministry of Education of China , School of Medicine and Pharmacy, Ocean University of China , 5 Yushan Road, Qingdao 266003 , Shandong , P.R. China.
authors.forename: Fei
authors.initials: F
authors.lastname: Cao
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Fang
authors.forename: Chang-Yun
authors.initials: CY
authors.lastname: Wang
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D002681:China; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D013256:Steroids / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: C000596591:25-acetate-nebrosteroid K; D013256:Steroids
keywords: 19-oxygenated steroid; Dichotella gemmacea; gorgonian; structure elucidation