title: Biochemical markers of bone metabolism in breast cancer.
abstract: The relationship between biochemical markers of bone resorption (C-terminal telopeptide, deoxypyridinoline, tartrate-resistant acid phosphatase 5b) and osteosynthesis (bone alkaline phosphatase) and clinical manifestations of bone metastases were studied in 239 patients with breast cancer with and without signs of bone involvement. High levels of C-terminal telopeptide and bone alkaline phosphatase were associated with poor prognosis: more severe skeletal complications and lesser survival values. These biochemical markers can be used for prognosis and optimization of therapy for bone metastases in patients with breast cancer.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, the Russian Academy of Medical Sciences, Moscow, Russia, biochimia@mtu-net.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Lyubimova
authors.forename: G V
authors.initials: GV
authors.lastname: Kozharskaya
authors.forename: S M
authors.initials: SM
authors.lastname: Portnoi
authors.forename: N E
authors.initials: NE
authors.lastname: Kushlinskii
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000556:secondary*; D001862:Bone Resorption / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D024042:Collagen Type I / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D010012:Osteogenesis / Q000235:genetics / Q000502:physiology*; D010455:Peptides / Q000378:metabolism; D011379:Prognosis; D011877:Radionuclide Imaging; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D000596:Amino Acids; D014408:Biomarkers, Tumor; D024042:Collagen Type I; D007527:Isoenzymes; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase