title: MR quantification of total liver fat in patients with impaired glucose tolerance and healthy subjects.
abstract: OBJECTIVE
  To explore the correlations between liver fat content and clinical index in patients with impaired glucose tolerance (IGT) and healthy subjects.
  
  
  METHODS
  56 subjects were enrolled and each of them underwent upper-abdominal MRI examination that involved a T1 VIBE Dixon sequence. 14 was clinically diagnosed with IGT (collectively as IGT group ) while 42 showed normal glucose tolerance,(collectively as NGT group). NGT group was further divided into NGTFat (BMI≥25, 18 subjects) and NGTLean (BMI<25, 24 subjects). The total liver fat contents was measured and compared with clinical findings and laboratory results in order to determine statistical correlations between these parameters. Differences among IGT, NGTFat and NGTLean groups were evaluated.
  
  
  RESULTS
  For all the subjects, fat volume fractions (FVFs) ranged from 4.2% to 24.2%, positive correlations was observed with BMI, waist hip ratio(WHR), low density lipoprotein(LDL), fasting plasma insulin(FPI), homeostasis model assessment insulin resistance (HOMA-IR) and homeostasis model assessment β(HOMAβ). FVFs of IGT group (p = 0.004) and NGTFat group (p = 0.006) were significantly higher than those of NGTLean group.
  
  
  CONCLUSIONS
  People with higher BMI, WHR and LDL levels tend to have higher liver fat content. Patients with BMI≥25 are more likely to develop IGT. Patients with higher FVF showed higher resistance to insulin, thus obtained a higher risk of developing type 2 diabetes mellitus.
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Dong
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Yanji
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
authors.forename: Zhongwei
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Huasong
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Endocrinology and Diabetes Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors.forename: Yanbing
authors.initials: Y
authors.lastname: Li
authors.affiliation: Medical Imaging Department, Union Hospital, Hong Kong.
authors.forename: Tao
authors.initials: T
authors.lastname: Chan
authors.affiliation: Department of Radiology, Kiang Wu Hospital, Macao.
authors.forename: Ling
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Zi-Ping
authors.initials: ZP
authors.lastname: Li
authors.affiliation: Department of Radiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Shi-Ting
authors.initials: ST
authors.lastname: Feng
mesh_terms: D050154:Adiposity; D005260:Female; D005951:Glucose Tolerance Test; D064368:Healthy Volunteers; D006801:Humans; D008099:Liver / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D019047:Phantoms, Imaging; D018709:Statistics, Nonparametric