title: Impact of a pharmaceutical care programme on health-related quality of life among women with epilepsy: a randomised controlled trial (IPHIWWE study).
abstract: BACKGROUND
  Epilepsy is a complex chronic disorder which affects health-related quality of life (HRQOL), especially in women.
  
  
  METHODS
  This study is a pragmatic randomised controlled trial involving women with epilepsy (WWE) over 18 years of age.
  
  
  RESULTS
  One hundred eighty-two WWE entered the study and 144 (79.1%) completed it. The t-test for comparing the final QOLIE-31 scores between groups yielded a t = -2.166 and confidence interval (CI) (95%): -10.125; -0.4625, p-value =0.0319. The change (Δ) in the QOLIE-31 score for the IG was 12.45 points (p-value <0.001) and for the control group it was 2.61 (p-value =0.072). With 10.7 as the minimally important change we found a relative risk of 2.17 (CI: 1.37; 3.43) and a number needed to treat (NNT) of 3.5.
  
  
  CONCLUSIONS
  The study demonstrated that the application of a pharmaceutical care programme significantly improves HRQOL in WWE. The NNT we found allows a recommendation to implement the PC programme for the additional benefit that would be obtained in patients' HRQOL.
  
  
  BACKGROUND
  Current Controlled Trials ISRCTN46864306 IPHIWWE study.
authors.forename: Martha
authors.initials: M
authors.lastname: Losada-Camacho
authors.forename: Mario F
authors.initials: MF
authors.lastname: Guerrero-Pabon
authors.forename: Pilar
authors.initials: P
authors.lastname: Garcia-Delgado
authors.forename: Fernando
authors.initials: F
authors.lastname: Martínez-Martinez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006304:Health Status; D006801:Humans; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D063868:Patient Outcome Assessment; D010593:Pharmaceutical Services; D011788:Quality of Life; D012306:Risk; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000927:Anticonvulsants