title: Synthesis of cyclocaric acid A and comparison to material from Cyclocarya paliurus.
abstract: Components previously reported from Cyclocarya paliurus include the oleananes cyclocaric acids A and B, with cyclocaric acid A possessing an oxetane ring. Isolation of cyclocaric acid A from the plant extract and comparison to the literature report show that the compound originally reported as cyclocaric acid A is, in fact, hederagenin. This was confirmed by independent synthesis of the oxetane and indicates that cyclocaric acid A may not actually be a natural product.
authors.affiliation: Department of Chemistry and ‡Tennessee Center for Botanical Medicine Research, Middle Tennessee State University , Murfreesboro, Tennessee 37132, United States.
authors.forename: Matthew E
authors.initials: ME
authors.lastname: Wright
authors.forename: Jonathan
authors.initials: J
authors.lastname: Byrd
authors.forename: Chunnian
authors.initials: C
authors.lastname: He
authors.forename: Norma
authors.initials: N
authors.lastname: Dunlap
mesh_terms: D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis* / Q000737:chemistry; D029525:Juglandaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D004365:Drugs, Chinese Herbal; C413246:oleanane; D009828:Oleanolic Acid; C025763:hederagenin