title: Cerebrospinal fluid cytology of an endolymphatic sac tumor.
abstract: Endolymphatic sac tumor (ELST) is a rare neoplasm which is seldom evaluated by cytopathology. We report the clinicopathologic course and cytologic cerebrospinal fluid (CSF) findings in a 58-year-old patient with brainstem lesions who originally presented with vertigo but progressed to having left 7th, 8th, 9th, and 10th cranial nerve palsies, right-sided weakness, and occipital headaches. Cytospin of the CSF revealed large epithelioid cells similar to cells seen in a surgical resection of a brain mass three months previously. Review of the surgical specimen revealed a well-differentiated glandular and papillary neoplasm, most consistent with an endolymphatic sac tumor.
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: Jennifer P
authors.initials: JP
authors.lastname: Bynum
authors.forename: Justin
authors.initials: J
authors.lastname: Bishop
authors.forename: Syed Z
authors.initials: SZ
authors.lastname: Ali
mesh_terms: D001933:Brain Stem / Q000473:pathology / Q000528:radiation effects; D003937:Diagnosis, Differential; D004428:Ear Neoplasms / Q000134:cerebrospinal fluid* / Q000473:pathology* / Q000532:radiotherapy; D004712:Endolymphatic Sac / Q000473:pathology* / Q000528:radiation effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000134:cerebrospinal fluid* / Q000473:pathology* / Q000532:radiotherapy
keywords: cerebrospinal fluid; cytopathology; endolymphatic sac tumor; metastasis; middle ear