title: The miR-146a polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis : a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to explore whether the miR-146a polymorphism (rs2910164) confers susceptibility to systemic lupus erythematous (SLE) and rheumatoid arthritis (RA).
  
  
  METHODS
  A meta-analysis was conducted on the association of the miR-146a polymorphism with SLE and RA.
  
  
  RESULTS
  Five studies with 2013 patients and 2555 controls were included in the meta-analysis. Meta-analysis revealed no association between SLE and the miR-146a G allele (odds ratio, OR = 1.007, 95 % confidence interval, CI = 0.910-1.114, p = 0.888). Additionally, no associations were found between the miR-146a polymorphism and SLE using recessive or dominant models, or homozygote contrast. Meta-analysis using allele contrast, recessive and dominant models, as well as homozygote contrast failed to reveal an association between the miR-146a polymorphism and RA (OR for G allele = 1.114, 95 % CI = 0.892-1.391, p = 0.342).
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the miR-146a polymorphism is not associated with susceptibility to SLE and RA. However, considering the small number of studies, further studies are needed to confirm this result.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136-705, Seoul, Korea, lyhcgh@korea.ac.kr.
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: S-C
authors.initials: SC
authors.lastname: Bae
mesh_terms: D001172:Arthritis, Rheumatoid / Q000208:ethnology* / Q000235:genetics*; D044466:Asian People / Q000706:statistics & numerical data; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D015994:Incidence; D008180:Lupus Erythematosus, Systemic / Q000208:ethnology* / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012307:Risk Factors; D044465:White People / Q000706:statistics & numerical data
chemical_list: D005819:Genetic Markers; C542542:MIRN146 microRNA, human; D035683:MicroRNAs