title: Effect of acotiamide on gastric emptying in healthy adult humans.
abstract: BACKGROUND
  Acotiamide is a first-in-class drug that is used to treat functional dyspepsia (FD). It is considered that acotiamide acts as an antagonist on muscarinic autoreceptors in the enteric nervous system and inhibits acetylcholinesterase activity. We examined the effect of acotiamide on gastric emptying in healthy adult humans.
  
  
  METHODS
  Twelve healthy adult males were enrolled in this double-blind crossover study. Acotiamide or placebo was administered orally in the 12 subjects 30 min before ingestion of a nutritional liquid meal (400 Kcal/400 mL). Six of the 12 participants took 100 mg of acotiamide or placebo, and six of the 12 participants took 300 mg of acotiamide or placebo in a double-blind crossover fashion. All subjects underwent measurement of gastric emptying by the (13) C breath test.
  
  
  RESULTS
  After the meal with placebo was ingested, the %dose/h curve ascended. The %dose/h curve after a meal with 100 or 300 mg of acotiamide ascended in an identical manner compared with the results with placebo. No significant differences were observed at any studied time point, and there were no significant changes in gastric emptying parameters (gastric emptying coefficient, t-1/2ex and t-lag ex).
  
  
  CONCLUSIONS
  A single administration of 100 or 300 mg of acotiamide did not affect gastric emptying after a liquid meal in healthy adult humans. Acotiamide has profound effects on restoring delayed gastric emptying and impaired accommodation in patients with FD but may have no effect on gastric emptying in healthy subjects. Such pharmacological actions have not been observed in previous gastroprokinetic studies.
authors.affiliation: Department of General Medicine and Emergency Care, Faculty of Medicine, School of Medicine, Toho University, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Zai
authors.forename: Kei
authors.initials: K
authors.lastname: Matsueda
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Kusano
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Urita
authors.forename: Youichi
authors.initials: Y
authors.lastname: Saito
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kato
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001549:Benzamides / Q000494:pharmacology*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005746:Gastric Emptying / Q000187:drug effects*; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D001549:Benzamides; D018727:Muscarinic Antagonists; D013844:Thiazoles; C410959:Z 338
keywords: 13C breath test; acotiamide; gastric emptying