title: [Risk factors of anal function after transabdominal intersphincteric resection for low rectal cancer].
abstract: OBJECTIVE
  To explore the risk factors of anal function after transabdominal intersphincteric resection(ISR) for low rectal cancer.
  
  
  METHODS
  Clinical and follow-up data of 96 patients with low rectal cancer who underwent transabdominal ISR in our department from January 2005 to December 2012 were analyzed retrospectively. The Wexner scoring scale was used to evaluate the anal function and the risk factors of anal function were analyzed by the Cox proportional hazard model.
  
  
  RESULTS
  Ninety-six patients completed Wexner scoring scale with mean follow-up of 32.7 months. Eighty-three cases(86.5%) presented good continence with a Wexner score less than 10. There was negative correlation between Wexner score and follow-up duration (Pearson coefficient, -0.078, P=0.003). Univariate analysis suggested the distance less than 5 cm from tumor to anal verge(P=0.043), height less than 2 cm from anastomosis to anal verge (P=0.001) and neoadjuvant chemoradiotherapy(P=0.001) were the risk factors. Multivariate analysis revealed that distance less than 2 cm from anastomosis to anal verge(P=0.020) and neoadjuvant chemoradiotherapy(P=0.001) were independent risk factors for fecal incontinence.
  
  
  CONCLUSIONS
  Most patients have good continence after transabdominal ISR. A distance of less than 2 cm from anastomosis to anal verge and neoadjuvant chemoradiotherapy are independent risk factors for poor anal function after transabdominal ISR.
authors.affiliation: Department of Colorectal Surgery, Union Hospital, Fujian Medical University, Fuzhou 350001, China. cp3169@163.com.
authors.forename: Shenghui
authors.initials: S
authors.lastname: Huang
authors.forename: Pan
authors.initials: P
authors.lastname: Chi
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.forename: Xingrong
authors.initials: X
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Zongbin
authors.initials: Z
authors.lastname: Xu
authors.forename: Yanwu
authors.initials: Y
authors.lastname: Sun
authors.forename: Daoxiong
authors.initials: D
authors.lastname: Ye
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
mesh_terms: D001003:Anal Canal / Q000503:physiopathology*; D005242:Fecal Incontinence; D006801:Humans; D012004:Rectal Neoplasms / Q000503:physiopathology* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors