title: Antifungal and cytotoxic activities of Nannorrhops ritchiana roots extract.
abstract: This atudy was designed to evaluate the antifungal and cytotoxic activities of the Nannorrhops ritchiana (Mazari Palm) 80% methanol extract (NR-M) and its four crude extracts i.e., petroleum ether (NR-A), dichloromethane (NR-B), ethyl acetate (NR-C) and butanol (NR-D). The antifungal activity was determined by agar tube dilution method against nine fungal strains; Aspergillus flavus, Trichophyton longifusis, Trichophyton mentagrophytes, Aspergillus flavus and Microsporum canis were susceptible to the extracts with percentage inhibition of (70-80%). Extracts exhibited significant and good antifungal activity against various fungal strains. The results were deduced by comparing with those for miconazole, amphotericin B and ketoconazole as standard drugs. The fractions of methanolic extract were assayed for their brine shrimp cytotoxic activity. They exhibited low toxicity with LC50 values ranging from 285.7 to 4350.75 μg/mL at the concentration of obtained results warrant follow up through bioassay guided isolation of the active principles, future antiinfectious research.
authors.forename: Rehana
authors.initials: R
authors.lastname: Rashid
authors.forename: Farah
authors.initials: F
authors.lastname: Mukhtar
authors.forename: Abida
authors.initials: A
authors.lastname: Khan
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000633:toxicity; D028023:Arecaceae; D001156:Artemia / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D018517:Plant Roots; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D010936:Plant Extracts; D012997:Solvents