title: Isoniazid in autoimmunity: a trigger for multiple sclerosis?
abstract: Isoniazid (INH) is a prodrug activated by the mycobacterial enzyme KatG, a multifunctional catalase peroxidase. KatG converts INH to reactive antimycobacterial species. For decades, an association between INH and drug-induced lupus erythematosus has been recognized. We present the case of a patient with primary progressive multiple sclerosis whose disease commenced weeks after initiating INH therapy for prevention of tuberculosis. Possible mechanisms by which INH may trigger autoimmunity in humans are discussed.
authors.affiliation: Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
authors.forename: Bardia
authors.initials: B
authors.lastname: Nourbakhsh
authors.affiliation: Neurology Section, VA North Texas Health Care System, Medical Service, 4500 South Lancaster Rd, Dallas, TX 75216, USA.
authors.forename: Olaf
authors.initials: O
authors.lastname: Stüve
keywords: Autoimmunity; Isoniazid; Multiple Sclerosis