title: Determinants of nocturia severity in men, derived from frequency-volume charts.
abstract: OBJECTIVE
  Nocturia may be characterized by indices derived from the frequency-volume chart (FVC). The objective of this study was to determine how these parameters relate to the severity of nocturia in men with and without lower urinary tract symptoms (LUTS).
  
  
  METHODS
  A retrospective analysis of FVCs was performed in two cohorts of men: those presenting with LUTS in a New York ambulatory urology clinic and those from the longitudinal population-based Krimpen study. Nocturnal urine volume (NUV), nocturia index (Ni), nocturnal polyuria index (NPi), nocturnal maximal voided volume (nMVV) and sleep duration were derived from FVCs. Comparisons were made using Spearman's rank correlation coefficient between actual number of nightly voids (ANV) and the other diary parameters.
  
  
  RESULTS
  Eighty-eight consecutive men who presented with LUTS completed a 24 h FVC [median age 70 years, interquartile range (IQR) 64.5-74.5, median ANV 2, IQR 1.5-4]. Nocturnal voiding frequency and volume were analyzed in 1082 community-dwelling men (median age 61 years, IQR 56.1-66.4, range 49.4-78.2; median ANV 1.5, IQR 1.0-2.0, range 0-4.5). Both cohorts demonstrated strong correlations between nocturia severity (represented as ANV) and Ni (0.797, 0.658 for cohorts 1 and 2, respectively). There were moderate correlations between nocturia severity and NPi (0.545, 0.394), NUV (0.463, 0.432) and sleep duration (0.306, 0.272). The nMVV correlated poorly with nocturia severity (0.159, 0.146).
  
  
  CONCLUSIONS
  Treatment of nocturia should aim to match nocturnal urine production with bladder capacity. Given the lack of known effective pharmacotherapy for low bladder volume, the first attempt nocturia treatment could focus on volume reduction.
authors.affiliation: Department of Urology, SUNY Downstate College of Medicine , Brooklyn, NY , USA.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Avulova
authors.forename: Marco H
authors.initials: MH
authors.lastname: Blanker
authors.forename: Boris
authors.initials: B
authors.lastname: van Doorn
authors.forename: Jeffrey P
authors.initials: JP
authors.lastname: Weiss
authors.forename: J L H Ruud
authors.initials: JL
authors.lastname: Bosch
authors.forename: Johnson F
authors.initials: JF
authors.lastname: Tsui
authors.forename: Johnathan A
authors.initials: JA
authors.lastname: Khusid
authors.forename: David
authors.initials: D
authors.lastname: Golombos
authors.forename: Jerry G
authors.initials: JG
authors.lastname: Blaivas
mesh_terms: D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D004358:Drug Therapy; D006801:Humans; D059411:Lower Urinary Tract Symptoms / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D053158:Nocturia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D011141:Polyuria / Q000503:physiopathology*; D011788:Quality of Life; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012892:Sleep Deprivation / Q000503:physiopathology; D013997:Time Factors; D014554:Urination / Q000502:physiology*
keywords: Lower urinary tract symptoms; nocturia; quality of life; voiding diary