title: In vitro fertilization outcome in women with endometriosis & previous ovarian surgery.
abstract: OBJECTIVE
  Women with endometriosis often need in vitro fertilization (IVF) to concieve. There are conflicting data on the results of IVF in patients with endometriosis. This study was undertaken to elucidate the influence of endometriosis on IVF outcome to give the best counselling for infertile patient with this problem.
  
  
  METHODS
  The outcome measures in 78 patients with surgically confirmed endometriosis were compared with 157 patients with tubal factor infertility, all of whom have undergone IVF. The groups were matched for age and follicle stimulating hormone (FSH) levels. Outcome measures included number of follicles, number of oocytes, peak oestradiol (E2) concentrations and mean number of ampoules of gonadotropins. Cumulative pregnancy, miscarriage and live birth rates were calculated in both the groups.
  
  
  RESULTS
  Higher cancelation rates, higher total gonadotropin requirements, lower peak E2 levels and lower oocyte yield were found in women with endometriosis and previous surgery compared with those with tubal factor infertility. However, no differences were found in fertilization, implantation, pregnancy, miscarriage, multiple births and delivery rates between the endometriosis and tubal factor infertility groups.
  
  
  CONCLUSIONS
  The present findings showed that women with endometriosis and previous surgery responded less well to gonadotropins during ovarian stimulation and hence the cost of treatment to achieve pregnancy was higher in this group compared with those with tubal factor infertility. However, the outcome of IVF treatment in patients with endometriosis was as good as in women with tubal factor infertility.
authors.affiliation: Clinic for Gynecology & Obstetrics, Clinical Center of Nis, Serbia.
authors.forename: Sonja
authors.initials: S
authors.lastname: Pop-Trajkovic
authors.forename: Vesna
authors.initials: V
authors.lastname: Kopitovic
authors.forename: Jasmina
authors.initials: J
authors.lastname: Popovic
authors.forename: Vladimir
authors.initials: V
authors.lastname: Antic
authors.forename: Dragana
authors.initials: D
authors.lastname: Radovic
authors.forename: Radomir
authors.initials: R
authors.lastname: Zivadinovic
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D004715:Endometriosis / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology*; D009865:Oocytes / Q000254:growth & development / Q000473:pathology; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D005640:Follicle Stimulating Hormone