title: Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior.
abstract: Ultrasound-assisted crystallization (sonocrystallization) was used to prepare a mixture of nano- and micrometer-sized crystals of the monoclinic form of paracetamol-a widely used analgesic known for its particularly problematic mechanical behavior under compression (i.e. poor tabletability). The nano- and micrometer-sized crystals yielded a powder which exhibits elastic moduli and bulk cohesions that are significantly higher than those observed in samples consisting of macrometer-sized crystals, thus leading to enhanced tabletability without the use of excipients, particle coating, salt, or cocrystal formation. Experimental compaction and finite element analysis were utilized to rationalize the significantly improved compaction behavior of the monoclinic form of paracetamol.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ (UK). d.bucar@ucl.ac.uk.
authors.forename: Dejan-Krešimir
authors.initials: DK
authors.lastname: Bučar
authors.forename: James A
authors.initials: JA
authors.lastname: Elliott
authors.forename: Mark D
authors.initials: MD
authors.lastname: Eddleston
authors.forename: Jeremy K
authors.initials: JK
authors.lastname: Cockcroft
authors.forename: William
authors.initials: W
authors.lastname: Jones
keywords: crystal growth; nanostructures; polymorphism; powder compaction; sonocrystallization