title: Acute fibrinous organising pneumonia: a manifestation of trimethoprim-sulfamethoxazole pulmonary toxicity.
abstract: A 50-year-old man was treated with trimethoprim-sulfamethoxazole (TMP-SMX) for acute arthritis of his right big toe. Within a few days, he developed dyspnoea, hypoxaemia and diffuse pulmonary infiltrates. Symptoms improved with discontinuation of the antibiotic but worsened again with its reintroduction. An open lung biopsy was performed. We describe the workup performed and the factors that pointed to a final diagnosis of TMP-SMX-related pulmonary toxicity in the form of acute fibrinous organising pneumonia.
authors.affiliation: Department of Pulmonary & Sleep Medicine, Avera Medical Group, Sioux Falls, South Dakota, USA.
authors.forename: Fady
authors.initials: F
authors.lastname: Jamous
authors.affiliation: Department of Internal Medicine, University of South Dakota, Sioux Falls, South Dakota, USA.
authors.forename: Syed Zain
authors.initials: SZ
authors.lastname: Ayaz
authors.affiliation: Department of Physicians Laboratory, Avera McKennan Hospital, Sioux Falls, South Dakota, USA.
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Choate
mesh_terms: D056809:Alveolar Epithelial Cells; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001168:Arthritis / Q000188:drug therapy; D001706:Biopsy; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D005337:Fibrin