title: Asymmetric cell division of stem cells in the lung and other systems.
abstract: New insights have been added to identification, behavior and cellular properties of embryonic and tissue-specific stem cells over the last few years. The modes of stem cell division, asymmetric vs. symmetric, are tightly regulated during development and regeneration. The proper choice of a stem cell to divide asymmetrically or symmetrically has great consequences for development and disease because inappropriate asymmetric division disrupts organ morphogenesis, whereas uncontrolled symmetric division induces tumorigenesis. Therefore, understanding the behavior of lung stem cells could identify innovative solutions for restoring normal morphogenesis and/or regeneration of different organs. In this concise review, we describe recent studies in our laboratory about the mode of division of lung epithelial stem cells. We also compare asymmetric cell division (ACD) in the lung stem cells with other tissues in different organisms.
authors.affiliation: Rehabilitation Science Department, College of Applied Medical Sciences, King Saud University, KSA and Anatomy Department, Faculty of Medicine, Mansoura University Mansoura, Egypt.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Berika
authors.affiliation: Department of Pediatric and Neonatology, Benha Children Hospital Benha City, Egypt.
authors.forename: Marwa E
authors.initials: ME
authors.lastname: Elgayyar
authors.affiliation: Developmental Biology, Stem Cells and Regenerative Medicine Program, Keck School of Medicine and Ostrow School of Dentistry, Children's Hospital Los Angeles, University of Southern California Los Angeles, USA.
authors.forename: Ahmed H K
authors.initials: AH
authors.lastname: El-Hashash
keywords: asymmetric; behavior; cell division; stem cell; symmetric