title: Mitochondrial biogenesis in the acutely injured kidney.
abstract: Mitochondrial dysfunction within the tubular epithelium has been implicated in the pathogenesis of acute kidney injury. Inflammatory, ischemic, or toxic insults dysregulate mitochondrial dynamics, resulting in mitochondrial swelling, fission, and apoptosis. The coordinated processes of generating healthy mitochondria and clearing damaged organelles may contribute to the preservation and restoration of mitochondrial homeostasis. Emerging literature suggests that a master regulator of mitochondrial biogenesis, peroxisome proliferator-activated receptor-γ-coactivator-1α (PGC-1α), is highly expressed in the tubular epithelium of the healthy kidney, and its induction during the post-injury period may contribute to functional recovery from acute kidney injury.
authors.affiliation: Division of Nephrology and Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass., USA.
authors.forename: Mei
authors.initials: M
authors.lastname: Tran
authors.forename: Samir M
authors.initials: SM
authors.lastname: Parikh
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D000818:Animals; D019446:Endotoxemia / Q000473:pathology / Q000503:physiopathology; D004734:Energy Metabolism; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007687:Kidney Tubules, Proximal / Q000378:metabolism / Q000473:pathology; D018345:Mice, Knockout; D008928:Mitochondria / Q000502:physiology; D063269:Mitochondrial Turnover / Q000187:drug effects; D058990:Molecular Targeted Therapy; D047495:PPAR gamma / Q000502:physiology; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D017582:Renal Replacement Therapy; D018805:Sepsis / Q000150:complications; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000502:physiology
chemical_list: D047495:PPAR gamma; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; C485290:Ppargc1a protein, mouse; D014157:Transcription Factors