title: Value of heart-type fatty acid-binding protein (H-FABP) for emergency department patients with suspected acute coronary syndrome.
abstract: OBJECTIVE
  The aim of this study is testing the value of H-FABP in the early diagnosis of ACS alone or with routinely used biomarkers such as myoglobin, CK-MB, and cTn I in patients who admitted to emergency department (ED) with complaint of chest pain and suspected acute coronary syndrome.
  
  
  METHODS
  This prospective and cross-sectional study was performed at the Emergency Department of University hospital between June 2009 and September 2010. Patients who were admitted with chest pain within first 48 hours and suspected ACS were enrolled to the study. Blood samples were taken for CK-MB, myoglobin, cTnI and H-FABP The patients were divided into two groups (ACS and non ACS). Statistical analyse were used for relation of biomarkers with diagnosis of ACS.
  
  
  RESULTS
  A 66 patients were included to the study. H-FAPB values were positive in 15.2% patients. When H-FABP was added to routinely used biomarkers in the diagnosis of ACS, increasing was observed in all sensitivity, specificity, PPV and NPV values. However, this increase was not statistically significant.
  
  
  CONCLUSIONS
  H-FABP did not provide any significant change in early diagnosis and exclusion of ACS diagnosis when used either alone or combination with routinely used biomarkers.
authors.affiliation: Bağcılar Research and Training Hospital, Emergency Department.
authors.forename: Karakus Yilmaz
authors.initials: KY
authors.lastname: Banu
authors.affiliation: Bakirköy Dr. Sadi Konuk Research and Training Hospital, Emergency Department.
authors.forename: Ozüçelik Doğaç
authors.initials: OD
authors.lastname: Niyazi
authors.affiliation: Van Military Hospital, Emergency Department.
authors.forename: Cevik
authors.initials: C
authors.lastname: Erdem
authors.affiliation: Bağcılar Research and Training Hospital, Emergency Department.
authors.forename: Doğan Hatice
authors.initials: DH
authors.lastname: Dpekçi Afşin
authors.affiliation: Bağcılar Research and Training Hospital, Emergency Department.
authors.forename: Uzun
authors.initials: U
authors.lastname: Ozlem
authors.affiliation: Bağcılar Research and Training Hospital, Emergency Department.
authors.forename: Celik
authors.initials: C
authors.lastname: Yasemin
authors.affiliation: Faculty of Cerrahpaşa Medicine, Đstanbul University, Emergency department.
authors.forename: Ipekci
authors.initials: I
authors.lastname: Afsin
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D052279:Creatine Kinase, MB Form / Q000097:blood*; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*; D011446:Prospective Studies; D012372:ROC Curve; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D009211:Myoglobin; D052279:Creatine Kinase, MB Form
keywords: acute coronary syndrome; biomarker; heart-type fatty acid-binding protein