title: Efficacy of pentoxifylline and tadalafil in rat model of ischemic colitis.
abstract: OBJECTIVE
  The aim of this study is to investigate the efficacy of tadalafil against pentoxifylline in rat model of ischemic colitis (IC).
  
  
  METHODS
  Thirty-two Wistar albino rats were subjected to laparotomy and left colon devascularization to create an IC model and then randomly placed into four groups. Group-1 (sham group) was administered 0.9% NaCl following laparotomy, group 2 (control group) was administered 0.9% NaCl following induced IC, group 3 was given pentoxifylline (n = 8), and group 4 was given tadalafil. On the third day; macroscopic findings, Gomella's ischemic area and Wallace scoring, histopathological analysis, and Chiu scoring were performed, and malondialdehyde (MDA) measurement in ischemic colon tissue was carried out through chemical analysis.
  
  
  RESULTS
  Significant differences were observed in acidic fluid, bowel dilatation, and serosal change (p < .05). The ischemic area measured 63.3 mm(2) in the control group, 2.8 mm(2) in the pentoxifylline group (p = .0001), and 2.4 mm(2) (p = .0001) in the tadalafil group. A significant difference was seen between the sham group and the control and pentoxifylline groups (p < .01), in terms of Wallace score and Chiu classification. Similarly, a significant difference was determined between the control group and pentoxifylline and tadalafil groups (p < .01), but no significant difference was established between the pentoxifylline group and tadalafil group (p = .33). MDA measurement was found on an average to be 63.7 in the control group, 22.7 in group 3 and 22.8 in group 4 (p = 001).
  
  
  CONCLUSIONS
  Although tadalafil is superior to pentoxifylline, both drugs are considered to have positive effects.
authors.affiliation: 1Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
authors.forename: Enver
authors.initials: E
authors.lastname: Reyhan
authors.forename: Oktay
authors.initials: O
authors.lastname: Irkorucu
authors.forename: Ali
authors.initials: A
authors.lastname: Surmelioglu
authors.forename: Selvinaz
authors.initials: S
authors.lastname: Ozkara
authors.forename: Kamuran Cumhur
authors.initials: KC
authors.lastname: Deger
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aziret
authors.forename: Hasan
authors.initials: H
authors.lastname: Erdem
authors.forename: Suleyman
authors.initials: S
authors.lastname: Cetinkunar
authors.forename: Pelin
authors.initials: P
authors.lastname: Demirturk
authors.forename: Ahmet Ozer
authors.initials: AO
authors.lastname: Sehirli
mesh_terms: D000818:Animals; D002243:Carbolines / Q000627:therapeutic use*; D017091:Colitis, Ischemic / Q000188:drug therapy* / Q000209:etiology; D003106:Colon / Q000378:metabolism / Q000601:surgery; D004195:Disease Models, Animal; D005260:Female; D007813:Laparotomy; D008315:Malondialdehyde / Q000378:metabolism; D010431:Pentoxifylline / Q000627:therapeutic use*; D058986:Phosphodiesterase 5 Inhibitors / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D058986:Phosphodiesterase 5 Inhibitors; D010975:Platelet Aggregation Inhibitors; D008315:Malondialdehyde; D000068581:Tadalafil; D010431:Pentoxifylline
keywords: ischemic colitis; malondialdehyde; pentoxifylline; phosphodiesterase-5; rat; tadalafil