title: Identifying otolaryngology systematic review research gaps: comparing Global Burden of Disease 2010 results with Cochrane Database of Systematic Review content.
abstract: OBJECTIVE
  Burden of disease should inform research prioritization.
  
  
  OBJECTIVE
  To determine whether systematic reviews and protocols published in the Cochrane Database of Systematic Reviews (CDSR) appropriately reflect disease burden for otolaryngologic conditions as measured by the Global Burden of Disease (GBD) 2010 project.
  
  
  METHODS
  Two investigators independently assessed 10 otolaryngologic conditions in CDSR for systematic review and protocol representation from March to June 2014. The otolaryngologic diseases were matched to their respective GBD 2010 disability-adjusted life-years (DALYs) to assess their correlation.
  
  
  METHODS
  Relationship of CDSR representation (based on systematic reviews and protocols) with percentage of total 2010 DALYs, 2010 DALY rank, and DALY percentage change from 1990 to 2010 for 10 otolaryngologic conditions.
  
  
  RESULTS
  All 10 otolaryngologic conditions were represented by at least 1 systematic review in CDSR. The number of reviews and protocols in CDSR was well matched with GBD 2010 disability metrics for only 1 disease, mouth cancer. Upper respiratory infections, otitis media, thyroid cancer, and cleft lip and cleft palate were overrepresented in CDSR, and esophageal cancer, "other hearing loss," nasopharynx cancer, larynx cancer, and "cancer of other part of pharynx and oropharynx" were underrepresented.
  
  
  CONCLUSIONS
  The representation of otolaryngologic conditions in CDSR correlates poorly with DALY metrics. The results of this study may guide future research prioritization and allocation of funds.
authors.affiliation: University of Colorado School of Medicine, Aurora.
authors.forename: Hannah
authors.initials: H
authors.lastname: Pederson
authors.affiliation: University of Colorado School of Medicine, Aurora.
authors.forename: Tyler
authors.initials: T
authors.lastname: Okland
authors.affiliation: Georgetown University School of Medicine, Washington, DC.
authors.forename: Lindsay N
authors.initials: LN
authors.lastname: Boyers
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, New York.
authors.forename: Chante
authors.initials: C
authors.lastname: Karimkhani
authors.affiliation: Department of Otolaryngology, State University of New York Downstate Medical Center, Brooklyn, New York.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Rosenfeld
authors.affiliation: Peninsula Dental School, Plymouth University, Plymouth, England.
authors.forename: Mona
authors.initials: M
authors.lastname: Nasser
authors.affiliation: Hunter New England Population Health, Wallsend, New South Wales, Australia7School of Medicine and Public Health, the University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Sze Lin
authors.initials: SL
authors.lastname: Yoong
authors.affiliation: School of Medicine and Public Health, the University of Newcastle, Newcastle, New South Wales, Australia.
authors.forename: Luke
authors.initials: L
authors.lastname: Wolfenden
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle.
authors.forename: Hmwe H
authors.initials: HH
authors.lastname: Kyu
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle.
authors.forename: Peter T
authors.initials: PT
authors.lastname: Serina
authors.affiliation: Institute for Health Metrics and Evaluation, University of Washington, Seattle.
authors.forename: Megan
authors.initials: M
authors.lastname: Coggeshall
authors.affiliation: Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora10Department of Epidemiology, Colorado School of Public Health, Aurora11Dermatology Service, US Department of Veterans Affairs Medical Center, Denver, Colorado.
authors.forename: Robert P
authors.initials: RP
authors.lastname: Dellavalle
mesh_terms: D006801:Humans; D017281:Cost of Illness; D016208:Databases, Factual; D010038:Otorhinolaryngologic Diseases / Q000453:epidemiology; D000078202:Systematic Reviews as Topic