title: Angiosarcoma Developing in a Vagal Schwannoma: A Rare Case Report.
abstract: Angiosarcoma arising in a schwannoma is extremely rare with only fourteen cases having been reported in the literature to the best of our knowledge. Amongst these fourteen, only five cases developed from vagal schwannoma. We describe a case of epithelioid angiosarcoma arising in a long standing vagal schwannoma in a 41 years male patient. Grossly the tumor was well encapsulated with variegated cut surface. On microscopy the tumor had two distinct components composed of benign schwannoma and malignant angiosarcoma which were further confirmed by immunohistochemistry. On further work up, he was found to have multiple distant metastases. This is the sixth reported case of angiosarcoma arising in a vagal schwannoma. The proposed histogenesis of this rare transformation, its prognostic factors and a review of literature regarding this entity is discussed.
authors.affiliation: Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060, India.
authors.forename: Vrushali
authors.initials: V
authors.lastname: Mahajan
authors.forename: Seema
authors.initials: S
authors.lastname: Rao
authors.forename: Pallav
authors.initials: P
authors.lastname: Gupta
authors.forename: Manish
authors.initials: M
authors.lastname: Munjal
authors.forename: Sangeet
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D003390:Cranial Nerve Neoplasms / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009442:Neurilemmoma / Q000473:pathology*; D014630:Vagus Nerve; D020421:Vagus Nerve Diseases / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor