title: The pregnancy outcome in patients with minor β-thalassemia.
abstract: BACKGROUND
  β-thalassemia is the most common hereditary disease in Iran and more than 2 million carriers of the β-thalassemia mutant gene are living in this country.
  
  
  OBJECTIVE
  To determine pregnancy outcome of women with β-thalassemia minor.
  
  
  METHODS
  In this retrospective, case-control study in two universities affiliated hospitals in Shiraz, all pregnancies occurred between 2006 and 2008 were included. Patients were divided in two groups regarding the presence of β-thalassemia minor. Patients in case and control groups were matched according to maternal age, gestational age and number of previous pregnancies. Cesarean delivery, hypertensive disorders, gestational diabetes mellitus, premature rupture of membranes and preterm labor were recorded in each group and were compared using the χ(2) or Fisher exact tests.
  
  
  RESULTS
  Overall 510 β-thalassemia minor subjects and 512 healthy controls were studied. Cases with β-thalassemia minor had significantly higher prevalence of oligohydramnios (p<0.001) and cesarean section delivery (p=0.001). There was no significant difference regarding Apgar score in 1(st) (p=0.65) and 5(th) minute (p=0.25), IUGR (p=0.073), gestational diabetes mellitus (DM) (p=0.443) and preeclampsia (p=0.116) between two study groups.
  
  
  CONCLUSIONS
  β-thalassemia minor does not significantly influence the pregnancy outcome in the negative way.
authors.affiliation: Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Sedigheh
authors.initials: S
authors.lastname: Amooee
authors.affiliation: Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Alamtaj
authors.initials: A
authors.lastname: Samsami
authors.affiliation: Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Jamileh
authors.initials: J
authors.lastname: Jahanbakhsh
authors.affiliation: Hematology Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Mehran
authors.initials: M
authors.lastname: Karimi
keywords: Gestational diabetes mellitus; Minor β-thalassemia; Oligohydramnios; Pregnancy outcome