title: Febrile seizure recurrence reduced by intermittent oral levetiracetam.
abstract: OBJECTIVE
  Febrile seizure (FS) is the most common form of childhood seizure disorders. FS is perhaps one of the most frequent causes of admittance to pediatric emergency wards worldwide. We aimed to identify a new, safe, and effective therapy for preventing FS recurrence.
  
  
  METHODS
  A total of 115 children with a history of two or more episodes of FS were randomly assigned to levetiracetam (LEV) and control (LEV/control ratio = 2:1) groups. At the onset of fever, LEV group was orally administered with a dose of 15-30 mg/kg per day twice daily for 1 week. Thereafter, the dosage was gradually reduced until totally discontinued in the second week. The primary efficacy variable was seizure frequency associated with febrile events and FS recurrence rate (RR) during 48-week follow-up. The second outcome was the cost effectiveness of the two groups.
  
  
  RESULTS
  The intention-to-treat analysis showed that 78 children in LEV group experienced 148 febrile episodes. Among these 78 children, 11 experienced 15 FS recurrences. In control group, 37 children experienced 64 febrile episodes; among these 37 children, 19 experienced 32 FS recurrences. A significant difference was observed between two groups in FS RR and FS recurrence/fever episode. The cost of LEV group for the prevention of FS recurrence is lower than control group. During 48-week follow-up period, one patient in LEV group exhibited severe drowsiness. No other side effects were observed in the same patient and in other children.
  
  
  CONCLUSIONS
  Intermittent oral LEV can effectively prevent FS recurrence and reduce wastage of medical resources.
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China ; Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Lin-Yan
authors.initials: LY
authors.lastname: Hu
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China ; Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zou
authors.affiliation: Department of Neurology, Jiang-Xi Children's Hospital Jiangxi, 330006, China.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Zhong
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.affiliation: Department of Neurology, Beijing Children's Hospital Beijing, 100045, China.
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Zhao
authors.affiliation: Department of Neurology, Children's Hospital of Chongqing Medical University Chongqing, 400014, China.
authors.forename: Nong
authors.initials: N
authors.lastname: Xiao
authors.affiliation: The Beijing new century children's Hospital Beijing, 100045, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Xiu-Yu
authors.initials: XY
authors.lastname: Shi
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ju
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Wei-Na
authors.initials: WN
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Chinese PLA General Hospital Beijing, 100583, China.
authors.forename: Xiao-Fan
authors.initials: XF
authors.lastname: Yang
authors.affiliation: Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne Melbourne, Australia ; Department of Medicine and Therapeutics, Chinese University of Hong Kong Hong Kong, China.
authors.forename: Patrick
authors.initials: P
authors.lastname: Kwan