title: Transcultural adaptation and validation of the "Adult Eosinophilic Esophagitis Quality of Life Questionnaire" into Spanish.
abstract: BACKGROUND
  The "Adult Eosinophilic Esophagitis Quality of Life (EoE-QoL-A) Questionnaire" was developed in English as a valid, reliable, and disease-specific health-related QoL measure.This research aims to adapt and validate this questionnaire for Spanish-speaking patients.
  
  
  METHODS
  A multicenter, observational, prospective study was conducted at 8 Spanish hospitals. The cultural adaptation of the original EoE-QoL-A questionnaire was undertaken through a standardized 3-phase procedure: 1. Translation; 2. Retrotranslation; and 3. Pilot study. Patients completed the Hospital Anxiety and Depression Scale (HADS), the Short Form (SF)-12, the Brief Illness Perception Questionnaire (BIPQ), and the adapted EoE-QoL-A, with a retest 3 months later.Statistical analysis included construct validity, internal consistency, criterion validity, and reproducibility.
  
  
  RESULTS
  One hundred and seventy adult EoE patients (73.5 % male; aged 33.5 ± 11.4-y) were included in the study.With regard to internal validity, all Cronbach alpha values were > 0.75. A significant correlation between items assessed in the SF-12, BIPQ and EoE-QoL-A questionnaires (p < 0.001) was observed. Correlations with the HADS were stronger for anxiety than for depression levels. Anxiety related to disease diagnosis and choking were the most affected dimensions; less affected were the dimensions related to eating, social, and emotional development. Intraclass correlation coefficients between the test and retest assessments were acceptable for all questionnaires, with the highest values (0.73-0.84) calculated for the EoE-QoL-A Spanish version.
  
  
  CONCLUSIONS
  The Spanish version of the EoE-QoL-A is a reliable, valid, and responsive questionnaire. Diagnosis and choking anxiety were the most affected dimensions in the health-related QoL in adult EoE patients.
authors.forename: Alfredo J
authors.initials: AJ
authors.lastname: Lucendo
authors.forename: Marta
authors.initials: M
authors.lastname: Sánchez-Cazalilla
authors.forename: Javier
authors.initials: J
authors.lastname: Molina-Infante
authors.forename: Isabel
authors.initials: I
authors.lastname: Pérez-Martínez
authors.forename: José M
authors.initials: JM
authors.lastname: Tenías
authors.forename: Jesús
authors.initials: J
authors.lastname: Barrio
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Nantes
authors.forename: Constanza
authors.initials: C
authors.lastname: Ciriza-de-los-Ríos
authors.forename: Antonia
authors.initials: A
authors.lastname: Perelló
authors.forename: Ángel
authors.initials: Á
authors.lastname: Arias
mesh_terms: D000328:Adult; D057765:Eosinophilic Esophagitis / Q000150:complications*; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014177:Translations; D055815:Young Adult