title: Relationship between systemic thrombogenic or thrombolytic indices and acute increase of spontaneous intracerebral hemorrhage.
abstract: OBJECTIVE
  The objective of this study was to determine the correlations between changes in thrombogenesis or thrombolysis related factors, and the acute increase of a spontaneous intracerebral hemorrhage (sICH).
  
  
  METHODS
  From January 2009 to October 2011, 225 patients with sICH were admitted to our hospital within 24 hours of onset. Among them, 111 patients with hypertensive sICH were enrolled in this study. Thrombogenic or thrombolytic factors were checked at admission. The authors checked computed tomography (CT) scans at admission and followed up the next day (between 12-24 hours) or at any time when neurologic signs were aggravated. Cases in which the hematoma was enlarged more than 33% were defined as Group A and the others were defined as Group B.
  
  
  RESULTS
  Group A included 30 patients (27%) and group B included 81 patients (73%). Factors including activated partial thromboplastin time, prothrombin time, fibrinogen, and D-dimer showed a greater increase in group A than in group B. Factors including antithrombin III, factor V, and factor X showed a greater increase in group A than in group B.
  
  
  CONCLUSIONS
  Based on the results of this study, it seems that the risk of increase in hematoma size can be predicted by serum thrombogenic or thrombolytic factors at admission.
authors.affiliation: Department of Neurosurgery, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Tack Geun
authors.initials: TG
authors.lastname: Cho
authors.affiliation: Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Jong Chul
authors.initials: JC
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Seung Won
authors.identifier: 0000-0001-8305-7501
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Neurosurgery, Dongguk University Kyungju Hospital, Dongguk University College of Medicine, Kyungju, Korea.
authors.forename: Chan
authors.initials: C
authors.lastname: Chung
authors.affiliation: Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Taek Kyun
authors.initials: TK
authors.lastname: Nam
authors.affiliation: Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
authors.forename: Sung Nam
authors.initials: SN
authors.lastname: Hwang
keywords: Correlation; Intracerebral hemorrhage; Spontaneous; Thrombogen; Thrombolysis