title: Core-shell Pd@Au nanoplates as theranostic agents for in-vivo photoacoustic imaging, CT imaging, and photothermal therapy.
abstract: Uniform plasmonic Pd@Au core-shell bimetallic nanoplates are synthesized by seeded growth strategy. Surface modified with SH-PEG makes it good biocompatibility, prolonged blood circulation, and relatively high tumor accumulation. Enhanced tumor contrast effects can be obtained for in vivo photoacoustic/CT imaging after intravenous injection of Pd@Au-PEG. Moreover, efficient photothermal tumor ablation is achieved, guided by the imaging techniques. This work promises further exploration of the superiority of 2D nanostructures for in vivo biomedical applications.
authors.affiliation: State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials and Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Chen
authors.forename: Shaoheng
authors.initials: S
authors.lastname: Tang
authors.forename: Zhide
authors.initials: Z
authors.lastname: Guo
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
authors.forename: Shiguang
authors.initials: S
authors.lastname: Mo
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Huang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Nanfeng
authors.initials: N
authors.lastname: Zheng
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D008807:Mice, Inbred BALB C; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy; D010165:Palladium / Q000737:chemistry*; D061088:Photoacoustic Techniques; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry; D020349:Surface Plasmon Resonance; D014057:Tomography, X-Ray Computed; D014183:Transplantation, Heterologous
chemical_list: D011092:Polyethylene Glycols; D010165:Palladium; D006046:Gold
keywords: 2D nanomaterials; core-shell; noble metal; photoacoustic imaging; photothermal therapy