title: [Liver injury and Nrf2 expression in neonatal rats with hyperoxia].
abstract: OBJECTIVE
  To investigate the effect of continuous exposure to hyperoxia on livers and changes in nuclear factor erythroid 2-related factor 2 (Nrf2) expression in hepatic tissues in neonatal rats.
  
  
  METHODS
  100 neonatal Sprague-Dawley rats were randomized divided into hyperoxia group (FiO = 95%, O group) and normal control group (FiOG2 = 21%, N group) immediately after birth. Hepatic apoptotic index and Nrf2 expression were detected by immunohistochemical methods on 4 d, 7 d, and 14 d.
  
  
  RESULTS
  Rats with hyperoxia had higher levels of hepatic apoptotic index and Nrf2 expression compared with the controls (P < 0.01). The levels of hepatic apoptotic index and Nrf2 expression in rats with hyperoxia were higher on 7 d and 14 d than those on 4 d (P < 0.01).
  
  
  CONCLUSIONS
  Continuous exposure to hyperoxia could result in hepatic damage to neonatal rats, with increased expression of Nrf2 as a mechanism of anti-oxidant.
authors.forename: Juan
authors.initials: J
authors.lastname: Ni
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Ma
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Jiang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis; D018496:Hyperoxia; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D051267:NF-E2-Related Factor 2; C495637:Nfe2l2 protein, rat