title: [Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].
abstract: We have performed a comparative study of the effects of S-amlodipine nicotinate and nimodipine on the local cerebral blood flow were studied in intact rats and those with model ischemic and hemorrhagic brain injury. It is established that S-amlodipine nicotinate produces a somewhat more pronounced enhancement of cerebral blood flow in rats with ischemic and hemorrhagic brain injury than in intact animals. In addition, S-amlodipine nicotinate significantly exceed nimodipine with respect to cerebrovascular activity in rats with brain pathology of both ischemic and hemorrhagic nature.
authors.forename: T S
authors.initials: TS
authors.lastname: Gan'shina
authors.forename: G A
authors.initials: GA
authors.lastname: Kim
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: I N
authors.initials: IN
authors.lastname: Kurdiumov
authors.forename: R S
authors.initials: RS
authors.lastname: Mirzoian
mesh_terms: D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001921:Brain / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D001929:Brain Edema / Q000188:drug therapy / Q000473:pathology; D001930:Brain Injuries / Q000188:drug therapy / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008833:Microcirculation / Q000187:drug effects*; D009525:Niacin / Q000494:pharmacology*; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; C519553:amlodipine nicotinate; D017311:Amlodipine; D009525:Niacin; D009553:Nimodipine