title: Mouse model of cervicovaginal papillomavirus infection.
abstract: Virtually all cervical cancers are caused by human papillomavirus infections. The efficient assembly of pseudovirus (PsV) particles incorporating a plasmid expressing a reporter gene has been an invaluable tool in the development of in vitro neutralization assays and in studies of the early mechanisms of viral entry in vitro. Here, we describe a mouse model of human papillomavirus PsV infection of the cervicovaginal epithelium that recapitulates the early events of papillomavirus infection in vivo.
authors.affiliation: Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37 Room 4112, 9000 Rockville Pike, Bethesda, MD, 20892, USA.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Çuburu
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Cerio
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Thompson
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Day
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002213:Capsid / Q000378:metabolism; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D018628:Gene Dosage; D017930:Genes, Reporter; D016679:Genome, Viral; D006801:Humans; D008156:Luciferases / Q000378:metabolism; D008807:Mice, Inbred BALB C; D009092:Mucous Membrane / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D013601:T-Lymphocytes / Q000378:metabolism; D014621:Vagina / Q000473:pathology / Q000821:virology*; D014771:Virion / Q000378:metabolism
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D008156:Luciferases