title: Long-range charge transport in single G-quadruplex DNA molecules.
abstract: DNA and DNA-based polymers are of interest in molecular electronics because of their versatile and programmable structures. However, transport measurements have produced a range of seemingly contradictory results due to differences in the measured molecules and experimental set-ups, and transporting significant current through individual DNA-based molecules remains a considerable challenge. Here, we report reproducible charge transport in guanine-quadruplex (G4) DNA molecules adsorbed on a mica substrate. Currents ranging from tens of picoamperes to more than 100 pA were measured in the G4-DNA over distances ranging from tens of nanometres to more than 100 nm. Our experimental results, combined with theoretical modelling, suggest that transport occurs via a thermally activated long-range hopping between multi-tetrad segments of DNA. These results could re-ignite interest in DNA-based wires and devices, and in the use of such systems in the development of programmable circuits.
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel.
authors.forename: Gideon I
authors.initials: GI
authors.lastname: Livshits
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel.
authors.forename: Avigail
authors.initials: A
authors.lastname: Stern
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel.
authors.forename: Dvir
authors.initials: D
authors.lastname: Rotem
authors.affiliation: Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Natalia
authors.initials: N
authors.lastname: Borovok
authors.affiliation: Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Gennady
authors.initials: G
authors.lastname: Eidelshtein
authors.affiliation: 1] Department of Chemistry, Duke University, Durham, North Carolina 27708, USA [2] School of Chemistry, Tel Aviv University, 69978 Tel Aviv, Israel.
authors.forename: Agostino
authors.initials: A
authors.lastname: Migliore
authors.affiliation: Department of Applied Physics and Applied Mathematics, 200 Mudd Building, 500 West 120th Street, Columbia University, New York 10027, USA.
authors.forename: Erika
authors.initials: E
authors.lastname: Penzo
authors.affiliation: Department of Applied Physics and Applied Mathematics, 200 Mudd Building, 500 West 120th Street, Columbia University, New York 10027, USA.
authors.forename: Shalom J
authors.initials: SJ
authors.lastname: Wind
authors.affiliation: 1] Department of Physics and Astronomy, University of Southern California, Los Angeles, California 90089, USA [2] Center S3, CNR Institute of Nanoscience, Via Campi 213/A, 41125 Modena, Italy.
authors.forename: Rosa
authors.initials: R
authors.lastname: Di Felice
authors.affiliation: Department of Physics, University of Cyprus, Nicosia 1678, Cyprus.
authors.forename: Spiros S
authors.initials: SS
authors.lastname: Skourtis
authors.affiliation: Departamento de Física Teórica de la Materia Condensada and Condensed Matter Physics Center (IFIMAC), Universidad Autónoma de Madrid, E-28049 Madrid, Spain.
authors.forename: Juan Carlos
authors.identifier: 0000000174210682
authors.initials: JC
authors.lastname: Cuevas
authors.affiliation: Department of Physics and Nanotechnology, Aalborg University, Skjernvej 4A, DK-9220 Aalborg, Denmark.
authors.forename: Leonid
authors.initials: L
authors.lastname: Gurevich
authors.affiliation: Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences and Center of Nanoscience and Nanotechnology, Tel Aviv University, Ramat Aviv 69978, Israel.
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Kotlyar
authors.affiliation: Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Jerusalem 91904, Israel.
authors.forename: Danny
authors.initials: D
authors.lastname: Porath
mesh_terms: D000538:Aluminum Silicates; D004247:DNA / Q000737:chemistry*; D004553:Electric Conductivity; D053770:Nanowires / Q000737:chemistry*
chemical_list: D000538:Aluminum Silicates; D004247:DNA; C011934:mica