title: A bone fide atypical fibroxanthoma of penis.
abstract: Malignant mesenchymal tumors of the penis are very rare and they have vascular origin. We present a case of a 71-year-old man with a painless nodule of 2.0 cm in diameter located in the penile foreskin. There was no history of urinary or sexually transmitted disease. An excisional biopsy revealed a markedly pleomorphic sarcoma resembling atypical fibroxanthoma (AFX) associated with a squamous cell carcinoma in situ. The patient refused a wide re-excision and was free of disease after 36 months. Because the different therapeutic management and prognosis, differential diagnosis should be made with sarcomatoid squamous cell carcinoma and melanoma: A diagnosis of AFX or malignant fibrous histiocytoma may be considered only after the complete exclusion of these two entities.
authors.affiliation: Deparment of Medicine and Surgery, University of Salerno, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Cuomo
authors.affiliation: Unit of Pathologic Anatomy, ASL Salerno, Hospital Scarlato, Scafati, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Addesso
authors.affiliation: Deparment of Medicine and Surgery, University of Salerno, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Altieri
authors.affiliation: Department of Pathologic Anatomy, A. O. U. S. Giovanni and Ruggi D' Aragona, Salerno, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Antonio
keywords: Atypical fibroxanthoma; CD10; differential diagnosis; penis