title: Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane.
abstract: Layered double hydroxide (LDH) has attracted considerable attention as a drug carrier. However, because of its poor in vivo behavior, polyethylene glycolylated (PEGylated) phospholipid must be used as a coformer to produce self-assembled core-shell nanoparticles. In the present study, we prepared a PEGylated phospholipid-coated LDH (PLDH) (PEG-PLDH) delivery system. The PEG-PLDH nanoparticles had an average size of 133.2 nm. Their core-shell structure was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy. In vitro liposome-cell-association and cytotoxicity experiments demonstrated its ability to be internalized by cells. In vivo studies showed that PEGylated phospholipid membranes greatly reduced the blood clearance rate of LDH nanoparticles. PEG-PLDH nanoparticles demonstrated a good control of tumor growth and increased the survival rate of mice. These results suggest that PEG-PLDH nanoparticles can be a useful drug delivery system for cancer therapy.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China ; School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Mina
authors.initials: M
authors.lastname: Yan
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Guangdong Pharmaceutical University, Guangzhou, People's Republic of China.
authors.forename: Shengmiao
authors.initials: S
authors.lastname: Cui
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Lei
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Zeng
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Liao
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Weijing
authors.initials: W
authors.lastname: Chu
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: Yihui
authors.initials: Y
authors.lastname: Deng
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, People's Republic of China.
authors.forename: Chunshun
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001798:Blood Proteins / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006878:Hydroxides / Q000737:chemistry* / Q000633:toxicity; D008727:Methotrexate / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry / Q000633:toxicity; D011092:Polyethylene Glycols / Q000737:chemistry / Q000633:toxicity; D017207:Rats, Sprague-Dawley; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D001798:Blood Proteins; D004337:Drug Carriers; D006878:Hydroxides; D010743:Phospholipids; D011092:Polyethylene Glycols; D008727:Methotrexate
keywords: cancer therapy; delivery system; lipid membrane; positive charge