title: Moonlighting functions of the NRZ (mammalian Dsl1) complex.
abstract: The yeast Dsl1 complex, which comprises Dsl1, Tip20, and Sec39/Dsl3, has been shown to participate, as a vesicle-tethering complex, in retrograde trafficking from the Golgi apparatus to the endoplasmic reticulum. Its metazoan counterpart NRZ complex, which comprises NAG, RINT1, and ZW10, is also involved in Golgi-to-ER retrograde transport, but each component of the complex has diverse cellular functions including endosome-to-Golgi transport, cytokinesis, cell cycle checkpoint, autophagy, and mRNA decay. In this review, we summarize the current knowledge of the metazoan NRZ complex and discuss the "moonlighting" functions and intercorrelation of their subunits.
authors.affiliation: Department of Molecular Life Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences Hachioji, Japan.
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Tagaya
authors.affiliation: Department of Molecular Life Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences Hachioji, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Arasaki
authors.affiliation: Department of Molecular Life Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences Hachioji, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Inoue
authors.affiliation: Department of Molecular Life Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences Hachioji, Japan.
authors.forename: Hana
authors.initials: H
authors.lastname: Kimura
keywords: CATCHR tether complex; NAG; RINT1; ZW10; autophagy; cell cycle; endoplasmic reticulum; mRNA decay