title: Metal-free tandem oxidative aryl migration and C-C bond cleavage: synthesis of α-ketoamides and esters from acrylic derivatives.
abstract: A novel tandem metal-free oxidative aryl migration/C-C bond-cleavage reaction, mediated by hypervalent iodine reagent, has been discovered. The presented transformation provided straightforward access to important α-ketoamide and α-ketoester derivatives from readily available acrylic derivatives via a concerted process of 1,2-aryl shift concomitant with C-C bond cleavage.
authors.affiliation: School of Pharmaceutical Science and Technology, Tianjin University , Tianjin 300072, China.
authors.forename: Le
authors.initials: L
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Daisy
authors.initials: D
authors.lastname: Zhang-Negrerie
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Du
authors.forename: Kang
authors.initials: K
authors.lastname: Zhao
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007202:Indicators and Reagents / Q000737:chemistry; D007455:Iodine / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000179:Acrylates; D004952:Esters; D007202:Indicators and Reagents; D008670:Metals; D007455:Iodine