title: Roles of miR-497 and its potential signaling pathway in diseases and with vascular endothelial growth factor.
abstract: MicroRNA (miRNA) is a class of small endogenous non-coding RNAs that are ∼ 22 nucleotides in length and can have structural, enzymatic and post-transcriptional regulators of gene expression targeting mRNA for translational repression and/or degradation. miR-497 is high on the list of noncoding, small, regulatory RNAs that plays important roles in the pathogenesis of some diseases and takes part in some signaling pathways in some diseases, but many questions await answers. Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. There might be an association between miRNA-497 and VEGF. This review was performed to sum up the roles of miR-497 and its potential signaling pathway in diseases and with VEGF.
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , China , and.
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.affiliation: a Department of Nephrology , The Sixth Affiliated Hospital of Sun Yat-Sen University , Guangzhou , Guangdong , China , and.
authors.forename: Zong-Pei
authors.initials: ZP
authors.lastname: Jiang
authors.affiliation: b Department of Nephrology , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , China.
authors.forename: Zhang-Suo
authors.initials: ZS
authors.lastname: Liu
authors.affiliation: b Department of Nephrology , The First Affiliated Hospital of Zhengzhou University , Zhengzhou , Henan , China.
authors.forename: Zhan-Zheng
authors.initials: ZZ
authors.lastname: Zhao
mesh_terms: D045744:Cell Line, Tumor; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism*
chemical_list: C559640:MIRN497 microRNA, human; D035683:MicroRNAs; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A
keywords: miR-497; signaling pathways; vascular endothelial growth factor