title: Analgesic, anti-inflammatory and anti-pyretic activities of aqueous ethanolic extract of Tamarix aphylla L. (Saltcedar) in mice.
abstract: The objective of the study was to investigate the analgesic, anti-inflammatory and anti-pyretic activity of aqueous ethanolic extracts of Tamarix aphylla. The powdered plant was extracted by the method of cold maceration using aqueous ethanol (70:30) as solvents. Analgesic activity was assessed by Eddy's hot plate method, formalin-induced paw licking and acetic acid-induced writhing in mice. Anti-inflammatory activity was evaluated by carageenan-induced mice paw edema. The anti-pyretic activity was determined by yeast-induced pyrexia in mice. The aqueous ethanolic extract of Tamarix aphylla showed 42% inhibition (p<0.005) of acetic acid- induced writhing, 63% reduction (p<0.005) in formalin-induced paw licking, and 42% increase (p<0.05) in reaction time as compared to normal control. The extract did not show significant anti-inflammatory activity. However, it showed significant antipyretic effect (p<0.005). The results of this study demonstrate that aqueous ethanolic extract of Tamarix aphylla exhibit analgesic and antipyretic activity but lacks anti-inflammatory activity.
authors.affiliation: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Qadir
authors.affiliation: College of Pharmacy, GC University, Faisalabad, Pakistan.
authors.forename: Khizar
authors.initials: K
authors.lastname: Abbas
authors.affiliation: College of Pharmacy, GC University, Faisalabad, Pakistan.
authors.forename: Rahma
authors.initials: R
authors.lastname: Hamayun
authors.affiliation: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D058633:Antipyretics / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D032363:Tamaricaceae
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D058633:Antipyretics; D010936:Plant Extracts