title: Biomarkers in acute kidney injury: are we ready for prime time?
abstract: Novel biomarkers are required to improve the timely detection of early acute kidney injury (AKI) and to improve the differential diagnosis, prognostic assessment, and management of AKI cases. It is anticipated that novel biomarkers of early structural AKI ('acute kidney damage') will provide critical diagnostic and prognostic stratification and complement functional markers such as serum creatinine. Further studies are required to conclusively demonstrate the association between early kidney damage biomarkers and clinical outcomes, both with and independently of functional markers, and to discern whether or not randomization to a treatment for AKI based on high structural/damage biomarker levels results in an improvement in kidney function and clinical outcomes.
authors.affiliation: Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
authors.forename: Prasad
authors.initials: P
authors.lastname: Devarajan
authors.forename: Patrick
authors.initials: P
authors.lastname: Murray
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000652:urine; D000209:Acute-Phase Proteins / Q000652:urine; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D050556:Fatty Acid-Binding Proteins / Q000652:urine; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000652:urine; D007677:Kidney Function Tests; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood / Q000652:urine; D008562:Membrane Glycoproteins / Q000652:urine; D015337:Multicenter Studies as Topic; D011518:Proto-Oncogene Proteins / Q000097:blood / Q000652:urine; D011991:Receptors, Virus; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; C000589760:IL18 protein, human; D020382:Interleukin-18; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D011991:Receptors, Virus; D003404:Creatinine