title: Fatal Canid Herpesvirus 1 Respiratory Infections in 4 Clinically Healthy Adult Dogs.
abstract: Four healthy adult dogs (Golden Retrievers aged 6 years and 9 years, Dalmatian aged 13 years, and Mastiff aged 5 years) developed clinical signs of acute respiratory disease and died within 2 to 7 days of onset of clinical signs. The lungs of the 3 dogs submitted for necropsy were diffusely and severely reddened due to hyperemia and hemorrhage. Microscopic lesions in all dogs were suggestive of acute viral or toxic respiratory damage and varied from acute severe fibrinonecrotic or hemorrhagic bronchopneumonia to fibrinous or necrotizing bronchointerstitial pneumonia. Necropsied dogs also had hemorrhagic rhinitis and tracheitis with necrosis. Virus isolation, transmission electron microscopy, and polymerase chain reaction were used to confirm the presence of canid herpesvirus 1 (CaHV-1) in the lung samples of these dogs. Lung tissues were negative for influenza A virus, canine distemper virus, canine parainfluenza virus, canine respiratory coronavirus, and canine adenovirus 2. Canid herpesvirus 1 has been isolated from cases of acute infectious respiratory disease in dogs but has only rarely been associated with fatal primary viral pneumonia in adult dogs. The cases in the current report document lesions observed in association with CaHV-1 in 4 cases of fatal canine herpesvirus pneumonia in adult dogs.
authors.affiliation: Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA edriskel@illinois.edu cooley@cvm.msstate.edu.
authors.forename: E A
authors.initials: EA
authors.lastname: Driskell
authors.affiliation: Department of Pathobiology and Population Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Cooley
authors.affiliation: Department of Basic Sciences, College of Veterinary University, Mississippi State University, Mississippi State, MS, USA.
authors.forename: K
authors.initials: K
authors.lastname: Jia
authors.affiliation: Department of Basic Sciences, College of Veterinary University, Mississippi State University, Mississippi State, MS, USA.
authors.forename: S
authors.initials: S
authors.lastname: Blackmon
authors.affiliation: Department of Basic Sciences, College of Veterinary University, Mississippi State University, Mississippi State, MS, USA.
authors.forename: X-F
authors.initials: XF
authors.lastname: Wan
authors.affiliation: Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: E W
authors.initials: EW
authors.lastname: Uhl
authors.affiliation: Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Saliki
authors.affiliation: Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sanchez
authors.affiliation: Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: P M
authors.initials: PM
authors.lastname: Krimer
authors.affiliation: Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Hogan
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary*; D002184:Herpesvirus 1, Canid / Q000302:isolation & purification*; D008168:Lung / Q000473:pathology; D008297:Male; D011024:Pneumonia, Viral / Q000473:pathology / Q000662:veterinary*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012141:Respiratory Tract Infections / Q000473:pathology / Q000662:veterinary*
keywords: canid herpesvirus 1; fatal; lungs; pneumonia; viral