title: Comparison of Serum Cystatin C and Creatinine Level Changes for Prognosis of Patients After Peripheral Arterial Angiography.
abstract: We compared changes in serum cystatin C (Cys C) and creatinine (sCr) levels for detecting contrast-induced acute kidney injury; 350 consecutive patients who underwent peripheral arterial angiography were prospectively enrolled. Serum Cys C and sCr levels were assayed at predefined time points after contrast-media exposure. During 1-year follow-up, major adverse events (MAEs) including all-cause mortality and dialysis were assessed. A sCr increase ≥25% was not associated with MAEs, whereas a serum Cys C increase ≥5% at 24 hours was associated with higher probability of MAEs (P = .010). The independent predictors of 1-year MAEs were older age (P = .004), lower prealbumin levels (P = .022), and serum Cys C increase ≥5%. In patients who underwent peripheral angiography, a serum Cys C increase ≥5% was an independent predictor of 1-year MAEs.
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Yanjiao
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xiaojiao
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Division of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Tang
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Minjie
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Wenji
authors.initials: W
authors.lastname: Wang
authors.affiliation: Division of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.affiliation: Division of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China guodaqiaoau@hotmail.com.
authors.forename: Daqiao
authors.initials: D
authors.lastname: Guo
authors.affiliation: Division of Nephrology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China dingfeng@sjtu.edu.cn.
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood* / Q000139:chemically induced* / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002681:China; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C / Q000378:metabolism*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood / Q000000981:diagnostic imaging* / Q000401:mortality; D011228:Prealbumin / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011859:Radiography; D006435:Renal Dialysis; D012307:Risk Factors; D013997:Time Factors
chemical_list: D015415:Biomarkers; C525030:CST3 protein, human; D003287:Contrast Media; D055316:Cystatin C; D011228:Prealbumin; D003404:Creatinine
keywords: contrast-induced acute kidney injury; prognosis; serum cystatin C