title: Traffic jams and shocks of molecular motors inside cellular protrusions.
abstract: Molecular motors are involved in key transport processes inside actin-based cellular protrusions. The motors carry cargo proteins to the protrusion tip which participate in regulating the actin polymerization and play a key role in facilitating the growth and formation of such protrusions. It is observed that the motors accumulate at the tips of cellular protrusions and form aggregates that are found to drift towards the protrusion base at the rate of actin treadmilling. We present a one-dimensional driven lattice model, where motors become inactive after delivering their cargo at the tip, or by loosing their cargo to a cargoless neighbor. The results suggest that the experimental observations may be explained by the formation of traffic jams that form at the tip. The model is solved using a novel application of mean-field and shock analysis. We find a new class of shocks that undergo intermittent collapses. Extensions with attachment and detachment events and relevance to experiments are briefly described.
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, P. O. Box 26, Rehovot 76100, Israel.
authors.forename: I
authors.initials: I
authors.lastname: Pinkoviezky
authors.affiliation: Department of Chemical Physics, Weizmann Institute of Science, P. O. Box 26, Rehovot 76100, Israel.
authors.forename: N S
authors.initials: NS
authors.lastname: Gov
mesh_terms: D000199:Actins / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology*; D022081:Cell Surface Extensions / Q000378:metabolism*; D004058:Diffusion; D007700:Kinetics; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism*; D011336:Probability
chemical_list: D000199:Actins; D020409:Molecular Motor Proteins