title: The Physiology of BDNF and Its Relationship with ADHD.
abstract: Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous system that plays a critical role in the physiological brain functions via its two independent receptors: tropomyosin-related kinase B (TrkB) and p75, especially in the neurodevelopment. Disrupting of BDNF and its downstream signals has been found in many neuropsychological diseases, including attention-deficit hyperactivity disorder (ADHD), a common mental disorder which is prevalent in childhood. Understanding the physiological functions of BDNF during neural development and its potential relationship with ADHD will help us to elucidate the possible mechanisms of ADHD and to develop therapeutic approaches for this disease. In this review, we summarized the important literatures for the physiological functions of BDNF in the neurodevelopment. We also performed an association study on the functional genetic variation of BDNF and ADHD by a case-control study in the Chinese mainland population and revealed the potential correlation between BDNF and ADHD which needs further research to confirm.
authors.affiliation: Department of Pathophysiology, School of Basic Medicine, Institute of Brain Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: De-Yi
authors.initials: DY
authors.lastname: Liu
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Shen
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: Fang-Fen
authors.initials: FF
authors.lastname: Yuan
authors.affiliation: Department of Pathophysiology, School of Basic Medicine, Institute of Brain Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: Ou-Yang
authors.initials: OY
authors.lastname: Guo
authors.affiliation: Department of Child Health Care, Hunan Children's Hospital, Changsha, 410007, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Pharmacology, School of Basic Medicine, Institute of Brain Research, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Chen
authors.affiliation: Department of Pathophysiology, School of Basic Medicine, Institute of Brain Research, Sino-Canada Collaborative Platform on Molecular Biology of Neurological Disease, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. zhulq1979@gmail.com.
authors.forename: Ling-Qiang
authors.initials: LQ
authors.lastname: Zhu
authors.affiliation: Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. wujingrlh@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Wu
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D000818:Animals; D044466:Asian People / Q000235:genetics; D001289:Attention Deficit Disorder with Hyperactivity / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D001923:Brain Chemistry; D019208:Brain-Derived Neurotrophic Factor / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000453:epidemiology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D006948:Hyperkinesis / Q000235:genetics; D007859:Learning Disabilities / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D020125:Mutation, Missense; D009419:Nerve Tissue Proteins / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D065886:Neurodevelopmental Disorders / Q000503:physiopathology; D055495:Neurogenesis / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D051381:Rats; D055647:Rats, Transgenic; D020813:Receptor, trkB / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C484065:NGFR protein, human; D009419:Nerve Tissue Proteins; D017475:Receptors, Nerve Growth Factor; C579455:BDNF protein, human; D020813:Receptor, trkB
keywords: ADHD; BDNF; Neural development; Val66Met