title: Physical activity in advanced Parkinson's disease: impact of subthalamic deep brain stimulation.
abstract: BACKGROUND
  Maintaining a physically active lifestyle promotes general health. Recent studies have demonstrated that patients with Parkinson's disease (PD) fail to meet the suggested levels of physical activity and that targeted interventions do not always improve this behavior. One validated treatment for motor symptoms in PD is subthalamic stimulation (STN DBS).
  
  
  OBJECTIVE
  Assess whether motor symptom improvement following STN DBS translated into increased physical activity behavior.
  
  
  METHODS
  Twenty patients with PD scheduled for bilateral STN DBS filled-out the Phone-FITT physical activity questionnaire and the SF-36 quality of life questionnaire prior to surgery and 6 to 9 months postoperatively. Data were compared to age- and gender-matched healthy controls.
  
  
  RESULTS
  Our results demonstrate that PD patients' quality of life is significantly lower than healthy controls. While STN DBS improves motor symptoms in the intermediate term, it only improves some aspects of quality of life related to physical function. Furthermore, STN DBS does not modify physical activity behavior measured by the Phone-FITT, whether for household or recreational activities.
  
  
  CONCLUSIONS
  The current study demonstrates that the motor improvements observed after STN DBS do not lead to systematic improvements in all aspects of quality of life or increased levels of physical activity. This highlights the need to develop and implement intervention strategies to promote an active lifestyle in this population, even if clinical improvement is evident following surgery.
authors.affiliation: Cone Laboratory for Research in Neurosurgery, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Daneault
authors.affiliation: Cone Laboratory for Research in Neurosurgery, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
authors.forename: Abbas F
authors.initials: AF
authors.lastname: Sadikot
authors.affiliation: Département des Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec, Canada.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Barbat-Artigas
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada Département de Kinanthropologie, Université du Québec à Montréal, Montréal, Québec, Canada.
authors.forename: Mylène
authors.initials: M
authors.lastname: Aubertin-Leheudre
authors.affiliation: Unité des troubles du mouvement André-Barbeau, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Jodoin
authors.affiliation: Unité des troubles du mouvement André-Barbeau, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada.
authors.forename: Michel
authors.initials: M
authors.lastname: Panisset
authors.affiliation: Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Québec, Canada Département de Kinanthropologie, Université du Québec à Montréal, Montréal, Québec, Canada.
authors.forename: Christian
authors.initials: C
authors.lastname: Duval
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D046690:Deep Brain Stimulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy*; D011788:Quality of Life; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000502:physiology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome
keywords: DBS; Parkinson; STN; exercise; quality of life