title: Intraocular pressure-lowering effects of commonly used fixed combination drugs with timolol in the management of primary open angle glaucoma.
abstract: OBJECTIVE
  To evaluate intraocular pressure (IOP)-lowering effect and ocular tolerability of brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies in the management of primary open angle glaucoma.
  
  
  METHODS
  Each drug was administered for two months, after which a circadian tonometric curve was recorded using a Goldmann applanation tonometer. Ocular discomfort (conjunctival hyperemia, burning or stinging, foreign body sensation, itching, ocular pain) of each eye was assessed by the subject on a standardized ocular discomfort scale.
  
  
  RESULTS
  Among the three study groups, there were no significant differences in the mean baseline IOP measurements, mean 2(nd) mo IOP measurements, and mean (%) change of IOPs from baseline. Among the three study groups, there were no significant differences in the mean IOP measurements obtained at circadian tonometric curves at baseline and at two months controls. In sum brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar effects on IOP levels.
  
  
  CONCLUSIONS
  Brimonidine/timolol, dorzolamide/timolol and latanoprost/timolol fixed combination therapies showed similar lowering efficaties on IOP levels whereas there was no any difference between each other.
authors.affiliation: Department of Ophthalmology, Sevgi Hospital, Malatya 44000, Turkey.
authors.forename: Murat Atabey
authors.initials: MA
authors.lastname: Ozer
authors.affiliation: Department of Ophthalmology, Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Ankara 06000, Turkey.
authors.forename: Mutlu
authors.initials: M
authors.lastname: Acar
authors.affiliation: Department of Ophthalmology, Pamukkale University Faculty of Medicine, Denizli 20000, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Yildirim
keywords: Intraocular pressure; brimonidine/timolol; dorzolamide/timolol; latanoprost/timolol; primary open angle glaucoma