title: [Expression of miR-126/miR-126* in hepatocelluar carcinoma and its correlation with clinical outcomes].
abstract: OBJECTIVE
  To investigate the expression of miR-126/miR-126* in hepatocellular carcinoma (HCC) tissues and its clinical significance.
  
  
  METHODS
  The expressions of miR-126/miR-126* in the tumor tissues and non-cancer tissues from 74 HCC cases were detected using real-time quantitative PCR. The correlation between miR-126/miR-126* expression and the clinicopathological features of the patients was analyzed.
  
  
  RESULTS
  Compared with the non-cancer tissues, HCC tissues showed significantly lowered expression levels of miR-126/miR-126*. A positive correlation was found between the expressions of miR-126 and miR-126* in the tumor tissues. Lower expressions of miR-126/miR-126* were significantly correlated with tumor recurrence and poor survival of the HCC patients.
  
  
  CONCLUSIONS
  The down-regulation of miR-126/miR-126* may play an important role in HCC metastasis and contributes to poor survival of HCC patients.
authors.affiliation: Department of Hepatobiliary Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.E-mail: hehuatiger@163.com.
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.forename: Yu
authors.initials: Y
authors.lastname: Huang
authors.forename: Dinghua
authors.initials: D
authors.lastname: Yang
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Liang
authors.initials: L
authors.lastname: Lin
authors.forename: Jia-Lu
authors.initials: JL
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Liao
authors.forename: Botang
authors.initials: B
authors.lastname: Guo
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009364:Neoplasm Recurrence, Local; D060888:Real-Time Polymerase Chain Reaction
chemical_list: C527111:MIRN126 microRNA, human; D035683:MicroRNAs