title: Terlipressin-induced ischemic skin necrosis: a rare association.
abstract: BACKGROUND
  Terlipressin is a synthetic vasopressin analogue that is used in the treatment of bleeding esophageal varices and hepatorenal syndrome in patients with cirrhosis. Serious ischemic adverse events, such as skin necrosis involving the extremities, scrotum, trunk, and abdominal skin, are rarely observed. In the literature to date, 20 cases that developed ischemic skin necrosis due to terlipressin usage have been reported.
  
  
  METHODS
  We report a patient with extensive skin necrosis on the infusion site of the right forearm and hand, which developed after the use terlipressin used to treat bleeding oesophageal varices in a 65-year-old man with cirrhosis.
  
  
  CONCLUSIONS
  Although rare, ischemic complications of terlipressin do occur.
authors.affiliation: Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Banu Demet
authors.initials: BD
authors.lastname: Ozel Coskun
authors.affiliation: Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Karaman
authors.affiliation: Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Gorkem
authors.affiliation: Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Irfan
authors.initials: I
authors.lastname: Buğday
authors.affiliation: Department of Gastroenterology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Orhan Kursad
authors.initials: OK
authors.lastname: Poyrazoğlu
authors.affiliation: Department of Pathology, Kayseri Training and Research Hospital, Kayseri, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Senel
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D005542:Forearm; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy; D006801:Humans; D008236:Lypressin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D000077585:Terlipressin; D014662:Vasoconstrictor Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014662:Vasoconstrictor Agents; D008236:Lypressin; D000077585:Terlipressin