title: Extranodal marginal zone B cell lymphoma of the orbit in a patient with sarcoidosis: a case report.
abstract: OBJECTIVE
  To describe a case of extranodal marginal zone B-cell lymphoma (EMZL) "mucosa associated lymphoid tissue (MALT)" of the orbit that presented with stage IV disease in a patient with sarcoidosis.
  
  
  METHODS
  Clinicopathologic case report.
  
  
  METHODS
  Biopsies of the lesion were performed in the operating room and the samples were submitted for pathology processing. Pathology analysis identified the lesion as an extranodal marginal zone B-cell lymphoma "mucosa associated lymphoid tissue (MALT)" via flow cytometry, histopathology, cytogenetics, and immunohistochemical staining and fluorescent in situ hybridization (FISH). The institutional review board of Howard University Hospital waived the need for IRB approval for this intraoperative finding.
  
  
  RESULTS
  A 70-year-old Black woman with biopsy-proven sarcoidosis presented complaining of foreign body sensation, redness, swelling of her left upper eyelid and tearing. The patient was found to have an orbital lymphoproliferative malignancy.
  
  
  CONCLUSIONS
  It is still unclear if the presence of immunosuppression or an autoimmune disease increases the risk of lymphoproliferative malignancies {6}. Malignancy should always be suspected and investigated.
authors.affiliation: Howard University Hospital - Department of Ophthalmology 2041 Georgia Ave., N.W. nrichards101521@gmail.com.
authors.forename: Nikisha Q
authors.initials: NQ
authors.lastname: Richards
authors.forename: Earl D R
authors.initials: ED
authors.lastname: Kidwell
authors.forename: Ali M
authors.initials: AM
authors.lastname: Ramadan
authors.forename: Tammey J
authors.initials: TJ
authors.lastname: Naab
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D007166:Immunosuppressive Agents