title: Effects of short term exposure of atrazine on the liver and kidney of normal and diabetic rats.
abstract: The present study evaluates the effects of short term (15 days) exposure of low dose (300 μg kg(-1)) of atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) on antioxidant status and markers of liver and kidney damage in normal (nondiabetic) and diabetic male Wistar rats. Rats were divided into four groups: Group I as normal control, Group II as atrazine treated, Group III as diabetic control, and Group IV as atrazine treated diabetic rats. Atrazine administration resulted in increased MDA concentration as well as increased activities of SOD, CAT, and GPx in both liver and kidney of atrazine treated and atrazine treated diabetic rats. However, GSH level was decreased in both liver and kidney of atrazine treated and atrazine treated diabetic rats. Atrazine administration led to significant increase in liver damage biomarkers such as AST, ALT, and ALP as well as kidney damage biomarkers such as creatinine and urea in both normal and diabetic rats, but this increase was more pronounced in diabetic rats when compared to normal rats. In conclusion, the results of the present study demonstrate that short term exposure of atrazine at a dose of 300 μg kg(-1) could potentially induce oxidative damage in liver and kidney of both normal and diabetic rats.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Dinesh Babu
authors.initials: DB
authors.lastname: Jestadi
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Alugoju
authors.initials: A
authors.lastname: Phaniendra
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Undru
authors.initials: U
authors.lastname: Babji
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Thupakula
authors.initials: T
authors.lastname: Srinu
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Bhavatharini
authors.initials: B
authors.lastname: Shanmuganathan
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry 605014, India.
authors.forename: Latha
authors.identifier: 0000-0001-6564-9415
authors.initials: L
authors.lastname: Periyasamy