title: The effect of dietary intake changes on nutritional status in acute leukaemia patients after first induction chemotherapy.
abstract: This study aimed to evaluate how changes in dietary intake among acute lymphoblastic and acute myeloid leukaemia (ALL and AML) patients affect nutritional status after the first induction chemotherapy. Dietary intake was assessed using 24-h recall and a 136-item food frequency questionnaire. Nutritional status was assessed by Patients Subjective Global Assessment questionnaire before starting induction therapy and again after 1 month. All newly diagnosed acute leukaemia patients aged 15 years old and older who attended three referral hospitals for initiation of their induction chemotherapy were included in the sample selection provided that they gave informed consent. A total of 30 AML and 33 ALL patients participated in the study. Dietary intake and nutritional status worsened after the chemotherapy treatment. Dietary intake in terms of macronutrients, micronutrients, food variety and diet diversity score changed significantly after the induction chemotherapy. No significant relationship was found between the changes in dietary indices and nutritional status. Chemotherapy-related side effects as an additional factor to cancer itself could affect dietary intake of leukaemia patients. The effectiveness of an early assessment of nutritional status and dietary intake should be further investigated in order to deter further deterioration.
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
authors.forename: Z
authors.initials: Z
authors.lastname: Malihi
authors.affiliation: Department of Food Science and Nutrition, Faculty of Applied Sciences, UCSI University, Kuala Lumpur, Selangor, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Kandiah
authors.affiliation: Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Institute of Gerontology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
authors.forename: Y M
authors.initials: YM
authors.lastname: Chan
authors.affiliation: Emergency Medicine Department, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Esfandbod
authors.affiliation: Rasoul Akram Hospital, Oncopathology Research Center, Iran University for Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Vakili
authors.affiliation: Imam Reza Hospital, Medical University for the Islamic Republic of Iran's Army, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Hosseinzadeh
authors.affiliation: Rasoul Akram Hospital, Iran University for Medical Sciences, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Zarif Yeganeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D042241:Early Diagnosis; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy / Q000379:methods; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008297:Male; D062407:Meals; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D009752:Nutritional Status / Q000187:drug effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D018977:Micronutrients
keywords: chemotherapy; dietary intake changes; leukaemia; nutritional status