title: Interobserver agreement for detection of malignant features of intraductal papillary mucinous neoplasms of the pancreas on MDCT.
abstract: OBJECTIVE
  The purpose of this retrospective study was to measure interobserver agreement in the assessment of malignant imaging features of intraductal papillary mucinous neoplasms (IPMNs) on MDCT.
  
  
  METHODS
  Pancreatic protocol CT studies were reviewed for 84 patients with resected IPMNs. Maximal diameter of the dominant cyst, presence of a mural nodule, presence of a solid component, and diameters of the main pancreatic duct (MPD) and common bile duct (CBD) were measured by four radiologists independently. In each patient, the IPMN was classified into one of three types: main duct, branch duct, or mixed IPMN. Interobserver agreement of lesion features was examined using the intraclass correlation coefficient (ICC) for continuous features and Fleiss kappa for categorical features.
  
  
  RESULTS
  The final dataset included 55 branch duct IPMNs, nine main duct IPMNs, and 20 mixed IPMNs. Moderate agreement (ĸ = 0.458; 95% CI, 0.345-0.564) was observed in assigning branch duct, main duct, or mixed IPMN subtypes. Measurement agreement was substantial to excellent for dominant cyst (ICC = 0.852; 95% CI, 0.777-0.907), MPD (0.753, 0.655-0.837), and CBD (0.608, 0.463-0.724) but only fair to moderate for the detection of the presence of mural nodule (ĸ = 0.284, 0.125-0.432) or solid component (ĸ = 0.405, 0211-0.577).
  
  
  CONCLUSIONS
  Substantial to excellent interobserver agreement in the measurement of cyst diameter, MPD, and CBD support their use for characterizing malignant features of IPMN on MDCT. However, the subjective interpretation of the presence of solid components and mural nodules by individual radiologists was more variable.
authors.affiliation: 1 Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Rm C-278, New York, NY 10065.
authors.forename: Richard K G
authors.initials: RK
authors.lastname: Do
authors.forename: Seth S
authors.initials: SS
authors.lastname: Katz
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Gollub
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Jennifer
authors.initials: J
authors.lastname: LaFemina
authors.forename: Emily C
authors.initials: EC
authors.lastname: Zabor
authors.forename: Chaya S
authors.initials: CS
authors.lastname: Moskowitz
authors.forename: David S
authors.initials: DS
authors.lastname: Klimstra
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Allen
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D015588:Observer Variation; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: MDCT; interobserver agreement; intraductal papillary mucinous neoplasm (IPMN); pancreatic cancer