title: Nutritional factors in transdifferentiation of scheletal muscles to adipocytes.
abstract: A current area of interest is the determination of factors able to promote the transition from muscle to adipose tissue. The current review has highlighted that treatment of myoblasts with fatty acids (especially oleic acid) and thiazolidindiones causes conversion to adipocytes. The molecular mechanisms mediating the adipogenic action of thiazolidinediones and fatty acids in myoblasts could involve peroxisome proliferators-activated receptor-gamma (PPARgamma and CCAAT-enhancer-binding protein C/EBP. The role of 1,25-D3 in adipogenesis is mediated at the molecular level through VDR-dependent inhibition of C/EBP and PPARgamma expression and a decrease in PPARgamma transactivation activity. Vitamin D supplementation increases muscle strength and ultimately reduces the incidence of falls. Additional research is needed to fully clarify the role of nutritional factors in adipogenesis.
authors.forename: A
authors.initials: A
authors.lastname: Pînzariu
authors.forename: Allia
authors.initials: A
authors.lastname: Sindilar
authors.forename: Raluca
authors.initials: R
authors.lastname: Haliga
authors.forename: Liliana
authors.initials: L
authors.lastname: Chelaru
authors.forename: Veronica
authors.initials: V
authors.lastname: Mocanu
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism; D023081:CCAAT-Binding Factor / Q000378:metabolism; D002117:Calcitriol / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics; D054338:Cell Transdifferentiation / Q000235:genetics; D019317:Evidence-Based Medicine; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D032342:Muscle Cells / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D032446:Myoblasts / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D045162:Thiazolidinediones / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D023081:CCAAT-Binding Factor; D005227:Fatty Acids; D047495:PPAR gamma; D045162:Thiazolidinediones; D014157:Transcription Factors; D002117:Calcitriol