title: Quantitative proteomic analysis of Down syndrome in the umbilical cord blood using iTRAQ.
abstract: Down sydrome (DS) is a relatively frequent chromosomal disorder, which has no safe and effective method of prenatal diagnosis to date. The present study was designed to identify DS biomarkers. We quantified the changes in the umbilical cord blood protein levels between DS-affected and healthy (control) pregnant females using isobaric tags for relative and absolute quantification (iTRAQ) and Gene Ontology (GO) analysis. A total of 505 proteins were identified, and of these, five proteins showed significantly different concentrations between the DS and the control group. These proteins may thus be relevant to DS and constitute potential DS biomarkers.
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Sui
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Ruohan
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Jiejing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Huiyan
authors.initials: H
authors.lastname: He
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Cui
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Minglin
authors.initials: M
authors.lastname: Ou
authors.affiliation: Key Laboratory of Laboratory Medical Diagnostics of Education Ministry, Chongqing Medical University, Chongqing, Sichuan 400016, P.R. China.
authors.forename: Wuxian
authors.initials: W
authors.lastname: Li
authors.affiliation: Key Laboratory of Laboratory Medical Diagnostics of Education Ministry, Chongqing Medical University, Chongqing, Sichuan 400016, P.R. China.
authors.forename: Suwen
authors.initials: S
authors.lastname: Qi
authors.affiliation: Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong 518020, P.R. China.
authors.forename: Jingli
authors.initials: J
authors.lastname: Wen
authors.affiliation: Clinical Medical Research Center, The Second Clinical Medical College of Jinan University (Shenzhen People's Hospital), Shenzhen, Guangdong 518020, P.R. China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Lin
authors.affiliation: Nephrology Department of Guilin 181st Hospital, Guangxi Key Laboratory of Metabolic Diseases Research, Guilin, Guangxi 541002, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Dai
mesh_terms: D000328:Adult; D002852:Chromatography, Ion Exchange; D004314:Down Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D015536:Down-Regulation; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D020543:Proteome / Q000032:analysis*; D040901:Proteomics; D053719:Tandem Mass Spectrometry; D015854:Up-Regulation
chemical_list: D020543:Proteome