title: Chymotrypsin-like activity of proteasomes and total calpain activity in gastric and colorectal cancer.
abstract: Chymotrypsin-like activity of proteasomes and total calpain activity were studied in patients with stage T2-4N0-3M0 gastric cancer and stage T2-4N0-2M0-1 colorectal cancer. Activities of proteasomes and calpains in gastric and colorectal cancer tissues were higher than in the corresponding normal tissues. Changes in activities of proteasomes and calpains were mutually related. The appearance of lymphogenic metastases in gastric cancer was associated with the increase in calpain activity. The progress of colorectal cancer and development of lymphogenic and hematogenic metastases were associated with elevated chymotrypsin-like activity of proteasomes.
authors.affiliation: Institute of Oncology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: E V
authors.initials: EV
authors.lastname: Ivanova
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
authors.forename: L V
authors.initials: LV
authors.lastname: Spirina
authors.forename: S G
authors.initials: SG
authors.lastname: Afanas'ev
authors.forename: A V
authors.initials: AV
authors.lastname: Avgustinovich
authors.forename: O V
authors.initials: OV
authors.lastname: Cheremisina
mesh_terms: D002154:Calpain / Q000378:metabolism*; D002918:Chymotrypsin / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000378:metabolism*; D005470:Fluorometry; D006801:Humans; D008207:Lymphatic Metastasis / Q000503:physiopathology*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000378:metabolism*
chemical_list: D002918:Chymotrypsin; D002154:Calpain; D046988:Proteasome Endopeptidase Complex