title: Optimized rapeseed oils rich in endogenous micronutrients ameliorate risk factors of atherosclerosis in high fat diet fed rats.
abstract: BACKGROUND
  Micronutrients in rapeseed such as polyphenols, tocopherols, phytosterols and phospholipids in rapeseed exert potential benefit to atherosclerosis. Some part of these healthy components substantially lost during the conventional refining processing. Thus some new processing technologies have been developed to produce various endogenous micronutrient-enriched optimized rapeseed oils. The aim of this study is to assess whether optimized rapeseed oils have positive effects on the atherosclerosis risk factors in rats fed a high-fat diet.
  
  
  METHODS
  Rats received experiment diets containing 20% fat and refined rapeseed oil or optimized rapeseed oils obtained with various processing technologies as lipid source. After 10 weeks of treatment, plasma was assayed for oxidative stress, lipid profiles and imflammation.
  
  
  RESULTS
  Micronutrients enhancement in optimized rapeseed oils significantly reduced plasma oxidative stress, as evaluated by the significant elevation in the activities of CAT and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. Optimized rapeseed oil with the highest micronutrient contents obtained by microwave pretreatment-cold pressing reduced the levels of TG, TC and LDL-C as well as IL-6 and CRP in plasma.
  
  
  CONCLUSIONS
  These results suggest that optimized rapeseed oils may contribute to prevent atherogenesis and make them very promising functional food in cardiovascular health promotion.
authors.forename: Jiqu
authors.initials: J
authors.lastname: Xu
authors.forename: Congcong
authors.initials: C
authors.lastname: Ma
authors.forename: Ling
authors.initials: L
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Chang
authors.initials: C
authors.lastname: Chen
authors.forename: Qianchun
authors.initials: Q
authors.lastname: Deng
authors.forename: Qingde
authors.initials: Q
authors.lastname: Huang
authors.affiliation: Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, P,R, China. fhhuang@foxmail.com.
authors.forename: Fenghong
authors.initials: F
authors.lastname: Huang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D029741:Brassica rapa / Q000737:chemistry*; D002097:C-Reactive Protein / Q000378:metabolism; D059305:Diet, High-Fat / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D005229:Fatty Acids, Monounsaturated; D015850:Interleukin-6 / Q000097:blood; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D018977:Micronutrients; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D000074262:Rapeseed Oil; D017208:Rats, Wistar; D012307:Risk Factors
chemical_list: D005229:Fatty Acids, Monounsaturated; D015850:Interleukin-6; D008055:Lipids; D018977:Micronutrients; D010936:Plant Extracts; D010938:Plant Oils; D000074262:Rapeseed Oil; D002097:C-Reactive Protein