title: Dysfunction of hippocampal interneurons in epilepsy.
abstract: Gamma-amino-butyric acid (GABA)-containing interneurons are crucial to both development and function of the brain. Down-regulation of GABAergic inhibition may result in the generation of epileptiform activity. Loss, axonal sprouting, and dysfunction of interneurons are regarded as mechanisms involved in epileptogenesis. Recent evidence suggests that network connectivity and the properties of interneurons are responsible for excitatory-inhibitory neuronal circuits. The balance between excitation and inhibition in CA1 neuronal circuitry is considerably altered during epileptic changes. This review discusses interneuron diversity, the causes of interneuron dysfunction in epilepsy, and the possibility of using GABAergic neuronal progenitors for the treatment of epilepsy.
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
authors.forename: Yu-Qiang
authors.initials: YQ
authors.lastname: Liu
authors.affiliation: Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.affiliation: Department of Immunology, Wuhan University, Wuhan, 430071, China.
authors.forename: Wan-Hong
authors.initials: WH
authors.lastname: Liu
authors.affiliation: Department of Pathophysiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: He
authors.affiliation: Department of Physiology, School of Basic Medical Sciences, Wuhan University, Wuhan, 430071, China. pengbiwen@whu.edu.cn.
authors.forename: Bi-Wen
authors.initials: BW
authors.lastname: Peng
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000503:physiopathology*; D059330:GABAergic Neurons / Q000502:physiology*; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology