title: PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting.
abstract: Genetic research has elucidated molecular mechanisms of heart failure (HF). Peroxisome proliferator-activated receptors (PPARs) seem to be important in etiology of HF. The aim of study was to find the correlation between PPARγ expression during development of HF in patients and coronary artery disease (CAD) after coronary artery bypass-grafting (CABG). Methods and Results. We followed up 157 patients (mean age 63) with CAD without clinical, laboratory, or echo parameters of HF who underwent CABG. Clinical and laboratory status were assessed before CABG and at 1, 12, and 24 months. During CABG slices of aorta (Ao) and LV were collected for genetic research. HF was defined as LVEF <40% or NT-proBNP >400 pg/mL or 6MWT <400 m. Patients were divided into 2 groups: with and without HF. PPARγ expression in Ao and LV was not increased in both groups at 2-year follow-up. Sensitivity of PPARγ expression in Ao above 1.1075 in detection of HF was 20.5% (AUC 0.531, 95% CI 0.442-0.619). Positive predictive value (Ppv) was 85.7%. Sensitivity and specificity of PPARγ expression in the LV in detection of HF were 58% and 92.9%, respectively (AUC 0.540, 95% CI 0.452-0.626). Ppv was 73.2%. Conclusion. PPARγ expression in Ao and LV was comparable and should not be used as predictive factor for development of HF in patients with CAD after CABG.
authors.affiliation: Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Izabela
authors.initials: I
authors.lastname: Wojtkowska
authors.affiliation: Department of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland.
authors.forename: Andrzej
authors.initials: A
authors.lastname: Tysarowski
authors.affiliation: Department of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Seliga
authors.affiliation: Department of Molecular Biology, Institute of Oncology, 5 Roentgena Street, 02-781 Warsaw, Poland.
authors.forename: Janusz A
authors.initials: JA
authors.lastname: Siedlecki
authors.affiliation: Department of Cardiosurgery and Transplantology, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Juraszyński
authors.affiliation: Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Milosz
authors.initials: M
authors.lastname: Marona
authors.affiliation: Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Lidia
authors.initials: L
authors.lastname: Greszata
authors.affiliation: Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Skrobisz
authors.affiliation: Department of Cardiology, Medical University of Bialystok, 27a Sklodowska Street, 15-276 Bialystok, Poland.
authors.forename: Karol
authors.initials: K
authors.lastname: Kaminski
authors.affiliation: Department of Cardiology, Medical University of Bialystok, 27a Sklodowska Street, 15-276 Bialystok, Poland.
authors.forename: Robert
authors.initials: R
authors.lastname: Sawicki
authors.affiliation: Intensive Cardiac Therapy Clinic, Institute of Cardiology, 42 Alpejska Street, 04-628 Warsaw, Poland.
authors.forename: Janina
authors.initials: J
authors.lastname: Stępińska