title: Relationship between CYP11B2-344T>C polymorphsim and atrial fibrillation: A meta-analysis.
abstract: BACKGROUND
  The aldosterone synthase (CYP11B2)-344T>C gene polymorphism has been reported to influence the risk of atrial fibrillation (AF) in many studies; however, the results remain controversial and ambiguous.
  
  
  METHODS
  We therefore carried out a meta-analysis of published case-control studies to investigate the association between CYP11B2-344T>C polymorphism and AF susceptibility. Electronic searches were conducted on links between this variant and AF in several databases. Odds ratios (ORs) and 95% confidence intervals (CIs) for homozygous, dominant model, recessive model and allele were calculated to estimate the strength of associations in fixed and random effect models. Heterogeneity and publication bias were also assessed.
  
  
  RESULTS
  A total of nine case-control studies were identified. The C allele was associated with an increased susceptibility risk of AF compared with the T allele among hypertension populations (OR=1.26; 95% CI=1.09-1.45). The contrast of homozygotes and the recessive model produced the same pattern of results as the allele contrast. In the hypertension population, a significant association was found for the genetic models that were examined.
  
  
  CONCLUSIONS
  Our pooled data suggest a significant association exists between CYP11B2-344T>C polymorphism and AF among hypertension populations.
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Fu
authors.affiliation: College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Ma
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Cardiology, Southwest Hospital, Third Military Medical University, Chongqing, China zysong2010@126.com.
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Song
mesh_terms: D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000235:genetics*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics
chemical_list: D019405:Cytochrome P-450 CYP11B2
keywords: Angiotensin-converting enzyme gene; CYP11B2; atrial fibrillation; meta-analysis; polymorphisms