title: Stereoselective synthesis of ε-lactones or spiro-heterocycles through NHC-catalyzed annulation: divergent reactivity by catalyst control.
abstract: NHC-catalyzed divergent annulation of enals with heterocyclic enones was developed to produce benzofuran/indole-containing ε-lactones or spiro-heterocycles in a highly diastereo- and enantioselective fashion. The chemo-selectivity controlled by the chiral catalyst backbone is particularly noteworthy.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Republic of Singapore. zhaoyu@nus.edu.sg.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Rong
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D007783:Lactones / Q000138:chemical synthesis*; D008697:Methane / Q000031:analogs & derivatives / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D013141:Spiro Compounds; C030011:carbene; D008697:Methane