title: miR-31 promotes proliferation of colon cancer cells by targeting E2F2.
abstract: MicroRNA-31 (miR-31) plays important roles in colon cancer development. However, the underlying mechanism is still not clear. We have explored the functions of miR-31 on proliferation of colon cancer cells as well as the underlying mechanism. E2F2 was identified as a direct target of miR-31. miR-31 regulated the proliferation of colon cancer cells by targeting E2F2. Moreover, in the present study, E2F2 acted as a tumor suppressor in colon cancer by repressing the expression of survivin and regulating the expression of CCNA2, C-MYC, MCM4 and CDK2. A possible mechanism for the function of miR-31 on colon cancer proliferation is presented and indicates that miR-31 might become a target for anti-cancer drug design.
authors.affiliation: School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, People's Republic of China, litong198824@163.com.
authors.forename: Tong
authors.initials: T
authors.lastname: Li
authors.forename: Wenjing
authors.initials: W
authors.lastname: Luo
authors.forename: Kunmei
authors.initials: K
authors.lastname: Liu
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Lv
authors.forename: Tao
authors.initials: T
authors.lastname: Xi
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D050703:E2F2 Transcription Factor / Q000037:antagonists & inhibitors*; D004847:Epithelial Cells / Q000502:physiology*; D020869:Gene Expression Profiling; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*
chemical_list: D050703:E2F2 Transcription Factor; C493761:E2F2 protein, human; C534612:MIRN31 microRNA, human; D035683:MicroRNAs