title: A universal isocyanide for diverse heterocycle syntheses.
abstract: Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.
authors.affiliation: Department of Drug Design, University of Groningen , Groningen, The Netherlands.
authors.forename: Pravin
authors.initials: P
authors.lastname: Patil
authors.forename: Kareem
authors.initials: K
authors.lastname: Khoury
authors.forename: Eberhardt
authors.initials: E
authors.lastname: Herdtweck
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000737:chemistry*; D000080:Acetals / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D000080:Acetals; D003486:Cyanides; D006571:Heterocyclic Compounds; D000079:Acetaldehyde