title: Non-interventional management of resistant hypertension.
abstract: Hypertension is one of the most popular fields of research in modern medicine due to its high prevalence and its major impact on cardiovascular risk and consequently on global health. Indeed, about one third of individuals worldwide has hypertension and is under increased long-term risk of myocardial infarction, stroke or cardiovascular death. On the other hand, resistant hypertension, the "uncontrollable" part of arterial hypertension despite appropriate therapy, comprises a much greater menace since long-standing, high levels of blood pressure along with concomitant debilitating entities such as chronic kidney disease and diabetes mellitus create a prominent high cardiovascular risk milieu. However, despite the alarming consequences, resistant hypertension and its effective management still have not received proper scientific attention. Aspects like the exact prevalence and prognosis are yet to be clarified. In an effort to manage patients with resistant hypertension appropriately, clinical doctors are still racking their brains in order to find the best therapeutic algorithm and surmount the substantial difficulties in controlling this clinical entity. This review aims to shed light on the effective management of resistant hypertension and provide practical recommendations for clinicians dealing with such patients.
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Michael
authors.initials: M
authors.lastname: Doumas
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Costas
authors.initials: C
authors.lastname: Tsioufis
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Charles
authors.initials: C
authors.lastname: Faselis
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Lazaridis
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Haris
authors.initials: H
authors.lastname: Grassos
authors.affiliation: Michael Doumas, Antonios Lazaridis, 2 Propedeutic Department of Internal Medicine, Aristotle University, 54643 Thessaloniki, Greece.
authors.forename: Vasilios
authors.initials: V
authors.lastname: Papademetriou
keywords: Adherence; Antihypertensive drugs; Resistant hypertension; Secondary hypertension; White coat hypertension