title: Effect of reduced coenzyme Q10 (ubiquinol) supplementation on blood pressure and muscle damage during kendo training camp: a double-blind, randomized controlled study.
abstract: OBJECTIVE
  This randomized controlled study was designed to examine the effects of reduced coenzyme Q10 (ubiquinol; CoQ10) supplementation on blood pressure (BP) and exercise-induced muscle damage in kendo athletes during a 4-day kendo training camp.
  
  
  METHODS
  In a double-blinded manner, 32 young kendo athletes were randomly assigned to supplement with either placebo or CoQ10 (600 mg) daily for 11 days from 1 week prior to camp to end of camp. BP was measured every morning after waking up during the training camp. Blood samples were taken at 3 time points; 1 week and 1 day prior and upon completion of training camp at 17:30. Statistical analysis was performed by repeated-measures analysis of variance followed by Bonferroni/Dunn post-hoc tests.
  
  
  RESULTS
  Before the training camp started, there were no differences in diastolic BP between these groups. However, after kendo training started, diastolic BP in the CoQ10 group was significantly lower than that in the placebo group (P<0.05). Plasma creatine kinase (CK) and myoglobin (Mb) concentrations were significantly increased in both groups during the camp (P<0.05), whereas there were no significant differences in CK and Mb between CoQ10 and placebo groups (CK: P=0.82, Mb: P=0.69).
  
  
  CONCLUSIONS
  Oral supplementation with reduced form of CoQ10 (ubiquinol; Kaneka QHTM) showed a significant hypotensive effect in young male kendo athletes during a 4-day kendo training camp, although it did not significantly ameliorate kendo exercise-induced muscle damage.
authors.affiliation: Department of Physiology and Biophysics, Gifu University Graduate School of Medicine, Gifu, Japan - era@gifu-u.ac.jp.
authors.forename: K
authors.initials: K
authors.lastname: Kizaki
authors.forename: T
authors.initials: T
authors.lastname: Terada
authors.forename: H
authors.initials: H
authors.lastname: Arikawa
authors.forename: T
authors.initials: T
authors.lastname: Tajima
authors.forename: H
authors.initials: H
authors.lastname: Imai
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Era
mesh_terms: D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects*; D003402:Creatine Kinase / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D016139:Martial Arts / Q000502:physiology*; D018482:Muscle, Skeletal / Q000187:drug effects*; D009211:Myoglobin / Q000097:blood; D010806:Physical Education and Training; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009211:Myoglobin; D014451:Ubiquinone; D003402:Creatine Kinase; C024989:coenzyme Q10