title: Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description.
abstract: The use of 2,4-dinitrophenol (DNP) has regained popularity as a weight loss aid in the last two decades due to increased marketing to bodybuilders and the increasing availability of this banned substance via the Internet. 2,4-DNP is a drug of narrow therapeutic index and toxicity results in hyperthermia, diaphoresis, tachycardia, tachypnoea and possible cardiac arrest and death. Skin toxicity from 2,4-DNP has not been reported since the 1930s. We report a case of a 21-year-old bodybuilding enthusiast who presented with a toxic exanthem after taking 2,4-DNP, and describe the first skin biopsy findings in a case of 2,4-DNP toxicity.
authors.affiliation: Department of Dermatology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Le
authors.affiliation: Anatomical Pathology, PathWest Laboratory Medicine, Perth, Western Australia, Australia.|QEII Medical Centre and School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wood
authors.affiliation: Department of Dermatology, Royal Perth Hospital, Perth, Western Australia, Australia.
authors.forename: Sujith Prasad
authors.initials: SP
authors.lastname: Kumarasinghe
mesh_terms: D019297:2,4-Dinitrophenol / Q000009:adverse effects*; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology*; D005076:Exanthema / Q000139:chemically induced* / Q000473:pathology*; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D019440:Anti-Obesity Agents; D019297:2,4-Dinitrophenol
keywords: 2; 4-dinitrophenol; DNP; bodybuilding; dinitrophenol; toxicity; weight loss