title: Enhancement of 18F-fluorodeoxyglucose metabolism in rat brain frontal cortex using a β3 adrenoceptor agonist.
abstract: We report the use of β3 adrenergic receptor mediated activation of rat brain frontal cortex using mirabegron (a selective β3 adrenoceptor agonist), measured by (18)F-FDG PET/CT. Another β3 agonist, CL 316,243, did not have this effect due to impermeability through the blood brain barrier (BBB), while atomoxetine, a norepinephrine transporter blocker, did increase (18)F-FDG uptake in the frontal cortex. Mirabegron exhibited a dose-dependent increase in frontal cortex (18)F-FDG uptake. These findings suggest a possible use of selective β3 adrenoceptor agonists in reversing regional glucose hypometabolism in the brain.
authors.affiliation: Preclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, California, 92697.
authors.forename: M Reza
authors.initials: MR
authors.lastname: Mirbolooki
authors.forename: Kimberly N
authors.initials: KN
authors.lastname: Schade
authors.forename: Cristian C
authors.initials: CC
authors.lastname: Constantinescu
authors.forename: Min-Liang
authors.initials: ML
authors.lastname: Pan
authors.forename: Jogeshwar
authors.initials: J
authors.lastname: Mukherjee
mesh_terms: D000083:Acetanilides / Q000494:pharmacology*; D058667:Adrenergic beta-3 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology*; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D005625:Frontal Lobe / Q000000981:diagnostic imaging* / Q000187:drug effects; D008297:Male; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology*; D014057:Tomography, X-Ray Computed
chemical_list: D000083:Acetanilides; D058667:Adrenergic beta-3 Receptor Agonists; D004149:Dioxoles; D019275:Radiopharmaceuticals; D013844:Thiazoles; D019788:Fluorodeoxyglucose F18; C076126:disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate; C520025:mirabegron
keywords: 18F-FDG; Alzheimer's disease; frontal cortex; β3 adrenoceptor