title: Bacterial and cellular RNAs at work during Listeria infection.
abstract: Listeria monocytogenes is an intracellular pathogen that can enter and invade host cells. In the course of its infection, RNA-mediated regulatory mechanisms provide a fast and versatile response for both the bacterium and the host. They regulate a variety of processes, such as environment sensing and virulence in pathogenic bacteria, as well as development, cellular differentiation, metabolism and immune responses in eukaryotic cells. The aim of this article is to summarize first the RNA-mediated regulatory mechanisms that play a role in the Listeria lifestyle and in its virulence, and then the host miRNA responses to Listeria infection. Finally, we discuss the potential cross-talk between bacterial RNAs and host RNA regulatory mechanisms as new mechanisms of bacterial virulence.
authors.affiliation: Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie Cellulaire et Infection, F-75015 Paris, France.
authors.forename: Nina
authors.initials: N
authors.lastname: Sesto
authors.forename: Mikael
authors.initials: M
authors.lastname: Koutero
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D007422:Intestines / Q000382:microbiology; D008089:Listeria monocytogenes / Q000235:genetics*; D008088:Listeriosis / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D064307:Microbiota; D012329:RNA, Bacterial / Q000235:genetics*; D037521:Virulence Factors
chemical_list: D035683:MicroRNAs; D012329:RNA, Bacterial; D037521:Virulence Factors
keywords: CRISPR; RNA secretion; asRNA; excludon; immune response; miRNA; riboswitch; sRNA; thermosensor; virulence