title: [Sparse evidence of antipsychotic drugs for the treatment of delirium].
abstract: Traditionally, haloperidol has been the recommended antipsychotic drug for pharmacological treatment of delirium, which is a frequent complication in the critical care setting. Due to a less frequent occurrence of extrapyramidal adverse effects, second-generation antipsychotic drugs have been evaluated. In the present paper we review the current randomized prospective studies of second-generation antipsychotics as treatment for delirium in hospitalized patients and conclude that so far the evidence in favour of these drugs compared with haloperidol is still sparse.
authors.affiliation: Klinisk Farmakologisk Afdeling, Aarhus Universitetshospital, Wilhelm Meyers Alle 4, 8000 Aarhus C. cua@farm.au.dk.
authors.forename: Charlotte U
authors.initials: CU
authors.lastname: Andersen
authors.forename: Lene
authors.initials: L
authors.lastname: Høimark
authors.forename: Karol
authors.initials: K
authors.lastname: Dabrowski
authors.forename: Kenneth Brandt
authors.initials: KB
authors.lastname: Hansen
authors.forename: Eva
authors.initials: E
authors.lastname: Sædder
mesh_terms: D000077582:Amisulpride; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003693:Delirium / Q000188:drug therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D000077152:Olanzapine; D010879:Piperazines / Q000627:therapeutic use; D000069348:Quetiapine Fumarate / Q000627:therapeutic use; D018967:Risperidone / Q000627:therapeutic use; D013469:Sulpiride / Q000031:analogs & derivatives / Q000627:therapeutic use; D013844:Thiazoles / Q000627:therapeutic use
chemical_list: D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; C092292:ziprasidone; D013469:Sulpiride; D000077582:Amisulpride; D018967:Risperidone; D000077152:Olanzapine