title: Dendocarbin A: a sesquiterpene lactone from Drimys winteri.
abstract: The natural compound dendocarbin A, C15H22O3, is a sesquiterpene lactone isolated for the first time from Drimys winteri for var chilensis. The compound crystallizes in the orthorhombic space group P2₁2₁2₁ and its X-ray crystal structure confirmed the S/R character of the chiral centres at C-5/C-10 and C-9/C-11, respectively. The α-OH group at C-11 was found to be involved in intermolecular hydrogen bonding, defining chains along the <100> 2₁ screw axis.
authors.affiliation: Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería, Universidad de La Frontera, Temuco, Chile.
authors.forename: Cristian
authors.initials: C
authors.lastname: Paz Robles
authors.affiliation: Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería, Universidad de La Frontera, Temuco, Chile.
authors.forename: Viviana
authors.initials: V
authors.lastname: Burgos
authors.affiliation: Departamento de Qumica Inorgnica, Analtica y Qumica, Fsica/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Sebastián
authors.initials: S
authors.lastname: Suarez
authors.affiliation: Gerencia de Investigación y Aplicaciones, Centro Atómico Constituyentes, Comisión Nacional de Energía Atómica, Buenos Aires, Argentina.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Baggio
mesh_terms: D018360:Crystallography, X-Ray; D032424:Drimys / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D012717:Sesquiterpenes; C000596737:dendocarbin A
keywords: Drimys winteri; crystal structure; cytotoxic activity; dendocarbin A; natural product; natural sesquiterpene lactone