title: Evaluation of the antiangiogenic effects of octreotide on growth hormone-producing pituitary adenoma using arterial spin-labeling perfusion imaging.
abstract: Decreased absolute tumor blood flow (TBF) measured by arterial spin labeling perfusion imaging (ASL-PI) on 3-tesla magnetic resonance imaging demonstrated the reduced size and growth hormone (GH) secretion of a large GH-producing pituitary adenoma in a 32-year-old man in response to octreotide therapy. The study shows the usefulness of ASL-PI in providing a biomarker of the antiangiogenic effect of octreotide.
authors.affiliation: Department of Neurosurgery, Hamamatsu University School of Medicine.
authors.forename: Naoto
authors.initials: N
authors.lastname: Sakai
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Takehara
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Baba
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Oki
authors.forename: Goro
authors.initials: G
authors.lastname: Takahashi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Koizumi
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Sameshima
authors.forename: Hiroki
authors.initials: H
authors.lastname: Namba
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015282:Octreotide / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000378:metabolism; D015203:Reproducibility of Results; D013113:Spin Labels
chemical_list: D020533:Angiogenesis Inhibitors; D018931:Antineoplastic Agents, Hormonal; D013113:Spin Labels; D019382:Human Growth Hormone; D015282:Octreotide