title: Relationship between tumour necrosis factor-related apoptosis inducing ligand (TRAIL) and vascular endothelial growth factor in human multiple myeloma patients.
abstract: Tumour necrosis factor-alfa (TNF-α) is an inflammatory cytokine with a wide spectrum of biological activity, including angiogenesis. Tumour necrosis factor-related apoptosis inducing ligand (TRAIL), which belongs to the TNF family of proteins, plays a role in the regulation of vascular responses, but its effect on the formation of new blood vessels (angiogenesis) is unclear. We analysed TRAIL concentrations in parallel with pro-angiogenic cytokines in serum and their expression in trephine biopsy (TB) in 56 patients with newly diagnosed IgG MM and 24 healthy volunteers. The study showed statistically higher concentrations of TRAIL and TNF-α, as well as of VEGF and its receptor, in MM patients compared to healthy volunteers and patients in advanced stages of the disease. Furthermore, we observed a significant decrease in all studied pro-angiogenic cytokines and significant increase of TRAIL concentration after anti-angiogenic therapy, with meaningful differences between responders (at least partial remission) and patients with progression during the induction treatment. It was also established that TRAIL correlated statistically and negatively with pro-angiogenic cytokines such as VEGF with its receptor and expression of VEGF and syndecan-1 in TB. In summary, our data indicate that in MM patients, both clinical course and treatment responsiveness are associated with dynamic yet corresponding changes of levels of TRAIL parallel pro-angiogenic mediators such as VEGF with its receptor and expression of VEGF and syndecan-1 in TB.
authors.affiliation: Department of Haematology, Medical University of Bialystok, Poland.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Bolkun
authors.affiliation: Department of Haematology, Medical University of Bialystok, Poland.|Department of Human Anatomy, Medical University of Bialystok, Poland.
authors.forename: Dorota
authors.initials: D
authors.lastname: Lemancewicz
authors.affiliation: Department of Haematology, Medical University of Bialystok, Poland.
authors.forename: Jaroslaw
authors.initials: J
authors.lastname: Piszcz
authors.affiliation: Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, Poland.|Department of Allergology and Internal Medicine, Medical University of Bialystok, Poland.
authors.forename: Marcin
authors.initials: M
authors.lastname: Moniuszko
authors.affiliation: Department of Pharmaceutical Technology, Medical University of Bialystok, Poland.
authors.forename: Urszula
authors.initials: U
authors.lastname: Bolkun-Skornicka
authors.affiliation: Department of Haematology, Medical University of Bialystok, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szkiladz
authors.affiliation: Department of Immunology, Medical University of Bialystok, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Jablonska
authors.affiliation: Department of Haematology, Medical University of Bialystok, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Kloczko
authors.affiliation: Department of Human Anatomy, Medical University of Bialystok, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Dzieciol
mesh_terms: D000368:Aged; D017209:Apoptosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics* / Q000473:pathology; D009389:Neovascularization, Pathologic; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
chemical_list: D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A
keywords: TRAIL; VEGF; angiogenesis; multiple myeloma; syndecan-1