title: In silico discovery of novel transcription factors regulated by mTOR-pathway activities.
abstract: The mammalian target of rapamycine (mTOR) pathway is a key regulator of cellular growth, development, and ageing, and unraveling its control is essential for understanding life and death of biological organisms. A motif-discovery workbench including nine tools was used to identify transcription factors involved in five basic (Insulin, MAPK, VEGF, Hypoxia, and mTOR core) activities of the mTOR pathway. Discovered transcription factors are classified as "process-specific" or "pathway-ubiquitous" with highlights toward their regulating/regulated activities within the mTOR pathway. Our transcription regulation results will facilitate further research on investigating the control mechanism in mTOR pathway.
authors.affiliation: Faculty of Biotechnology and Food Sciences, Lodz University of Technology Lodz, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Jablonska
authors.affiliation: Fundamental Research Laboratories, Sony Computer Science Laboratories Inc. Tokyo, Japan ; Systems Biology Institute Tokyo, Japan ; Graduate School of Medicine, Yokohama City University Yokohama, Japan.
authors.forename: Natalia
authors.initials: N
authors.lastname: Polouliakh
keywords: bioinformatic tools and databases; cell signaling; mTOR pathway; orthologous genes; transcription factors