title: An overview of eosinophilic esophagitis.
abstract: Eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease affecting both children and adults. The condition is characterized by an eosinophilic infiltration of the esophageal epithelium. Symptoms of esophageal dysfunction include dysphagia, food impaction and symptoms mimicking gastroesophageal reflux disease. Endoscopic examination typically reveals mucosal fragility, ring or corrugated mucosa, longitudinal furrows, whitish plaques or a small caliber esophagus. Histologic findings of >15 eosinophils per high-power field is the diagnostic hallmark of EoE. An elimination diet, topical corticosteroids or endoscopic dilation for fibrostenotic disease serve as effective therapeutic option.
authors.affiliation: Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Hyojin
authors.initials: H
authors.lastname: Park
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D002648:Child; D003680:Deglutition Disorders / Q000209:etiology; D003937:Diagnosis, Differential; D057765:Eosinophilic Esophagitis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D004940:Esophageal Stenosis / Q000209:etiology / Q000601:surgery*; D004945:Esophagoscopy; D004947:Esophagus / Q000473:pathology*; D005247:Feeding Behavior; D005764:Gastroesophageal Reflux / Q000175:diagnosis; D006801:Humans
chemical_list: D000305:Adrenal Cortex Hormones
keywords: Eosinophilic esophagitis; Gastroesophageal reflux; High-power field