title: Efficacy of triphaladi avaleha on beejadushtijanya pandu (thalassemia).
abstract: BACKGROUND
  Hemoglobinopathies constitute a major public health problem internationally, particularly in the developing world as it has the least resources for coping with the problem. Thalassemia is an inherited single-gene autosomal recessive disorder of the Red Blood Corpuscles (RBCs). Life becomes miserable due to blood transfusion every fortnight, recurrent infections, stunted growth, problems of iron overload, splenectomy, and decreased school performance. Nearly Rs. 1000 Crore is being spent in the treatment of thalassemia per annum.
  
  
  OBJECTIVE
  To evaluate the efficacy of Triphaladi Avaleha in Beejadushtijanya Pandu (thalassemia).
  
  
  METHODS
  Total 32 patients of age group 1-15 years were registered and randomly divided into two groups. Group A (test drug treated group) and Group B (control group). In Group A, Triphaladi Avaleha was given with Godugdha, and in Group B, Deferiprone was administered. Assessment was done based on the subjective and objective parameters after 12 weeks of treatment, with a follow-up of 8 weeks.
  
  
  RESULTS
  The trial drug proved better than the standard control in Paandutaa and Sandhishoola at a highly significant level and in Jwara, Akshikootashotha and Pindikodweshtana at a significant level. In Group A, five patients (38.46%) showed maximum improvement, five patients (38.46%) showed moderate improvement, two patients (15.38%) had mild improvement.
  
  
  CONCLUSIONS
  Triphaladi Avaleha has various properties which help to relieve the signs and symptoms of the disease, as well as decrease the iron overload.
authors.affiliation: Department of Kaumarabhritya, G. J. Patel Institute of Ayurveda Studies and Research, New Vallabh Vidyanagar, Anand, India.
authors.forename: Abhishek Y
authors.initials: AY
authors.lastname: Patalia
authors.affiliation: Department of Kaumarabhritya, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
authors.forename: Virendra Kumar
authors.initials: VK
authors.lastname: Kori
authors.affiliation: Department of Kaumarabhritya, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
authors.forename: Kalpana S
authors.initials: KS
authors.lastname: Patel
authors.affiliation: Department of Kaumarabhritya, Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar, Gujarat, India.
authors.forename: S
authors.initials: S
authors.lastname: Rajagopala
keywords: Beejadushtijanya Pandu; Triphaladi Avaleha; thalassemia