title: Prostate cancer: Important steps and considerations in the design of therapeutic vaccines.
abstract: Vaccine-based immunotherapy can increase the overall survival of patients with advanced prostate cancer. However, the efficacy of vaccine-elicited anticancer immune responses is heavily influenced by the physical, nutritional, and psychological status of the patient. Given their importance, these parameters should be carefully considered for the design of future clinical trials testing this immunotherapeutic paradigm in prostate cancer patients.
authors.affiliation: The John van Geest Cancer Research Centre; Nottingham Trent University; Nottingham, UK.
authors.forename: Stephanie Eb
authors.initials: SE
authors.lastname: McArdle
authors.affiliation: The John van Geest Cancer Research Centre; Nottingham Trent University; Nottingham, UK.
authors.forename: A Graham
authors.initials: AG
authors.lastname: Pockley
authors.affiliation: University of Reading; Reading, UK.
authors.forename: Glen R
authors.initials: GR
authors.lastname: Gibson
authors.affiliation: The John van Geest Cancer Research Centre; Nottingham Trent University; Nottingham, UK.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Rees
keywords: animal model; cancer vaccine; clinical trial; microbiota; prostate; stress