title: Mechanisms of immune tolerance to allergens: role of IL-10 and Tregs.
abstract: During the past 20 years, major advances have been made in understanding the molecular and cellular mechanisms of allergen tolerance in humans. The demonstration of T cell tolerance, particularly that mediated by the immune-suppressive functions of IL-10, led to a major conceptual change in this area. Currently, the known essential components of allergen tolerance include the induction of allergen-specific regulatory subsets of T and B cells, the immune-suppressive function of secreted factors, such as IL-10 and TGF-β, the production of IgG4 isotype allergen-specific blocking antibodies, and decreased allergic inflammatory responses by mast cells, basophils, and eosinophils in inflamed tissues.
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
authors.forename: Mübeccel
authors.initials: M
authors.lastname: Akdis
mesh_terms: D000485:Allergens / Q000276:immunology*; D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D016753:Interleukin-10 / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D000485:Allergens; C508609:IL10 protein, human; D016753:Interleukin-10