title: Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4'-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes.
abstract: A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4'-pyridines] in good yields is described here. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4'-pyridine] scaffolds using a double Michael addition/cyclization sequence.
authors.affiliation: Department of Biomolecular Sciences, Section of Organic Chemistry and Organic Natural Compounds, University of Urbino "Carlo Bo", Via I Maggetti 24, 61029 Urbino (PU), Italy. fabio.mantellini@uniurb.it.
authors.forename: Orazio
authors.initials: O
authors.lastname: A Attanasi
authors.forename: Linda
authors.initials: L
authors.lastname: A Campisi
authors.forename: Lucia
authors.initials: L
authors.lastname: De Crescentini
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Favi
authors.forename: Fabio
authors.initials: F
authors.lastname: Mantellini
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D007211:Indoles / Q000737:chemistry*; D000078183:Oxindoles; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007211:Indoles; D000078183:Oxindoles; D011725:Pyridines; D013141:Spiro Compounds; C022960:2-oxindole; C023666:pyridine