title: Evidence-based assessment of proton-pump inhibitors in Helicobacter pylori eradication: a systematic review.
abstract: Peptic ulcer disease continues to be issue especially due to its high prevalence in the developing world. Helicobacter pylori (H. pylori) infection associated duodenal ulcers should undergo eradication therapy. There are many regimens offered for H. pylori eradication which include triple, quadruple, or sequential therapy regimens. The central aim of this systematic review is to evaluate the evidence for H. pylori therapy from a meta-analytical outlook. The consequence of the dose, type of proton-pump inhibitor, and the length of the treatment will be debated. The most important risk factor for eradication failure is resistance to clarithromycin and metronidazole.
authors.affiliation: Vinayak Nagaraja, Guy D Eslick, The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, NSW 2751, Australia.
authors.forename: Vinayak
authors.initials: V
authors.lastname: Nagaraja
authors.affiliation: Vinayak Nagaraja, Guy D Eslick, The Whiteley-Martin Research Centre, Discipline of Surgery, The University of Sydney, Nepean Hospital, Penrith, NSW 2751, Australia.
authors.forename: Guy D
authors.initials: GD
authors.lastname: Eslick
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D016017:Odds Ratio; D010437:Peptic Ulcer / Q000382:microbiology / Q000517:prevention & control; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors
keywords: Helicobacter pylori; Peptic ulcer disease; Proton-pump inhibitors; Systematic review