title: Effect of inhalational anaesthetic on postoperative cognitive dysfunction following radical rectal resection in elderly patients with mild cognitive impairment.
abstract: OBJECTIVE
  To determine the effect of choice of inhalational anaesthetic (sevoflurane vs propofol) on the incidence and severity of postoperative cognitive dysfunction (POCD) in elderly patients (aged ≥ 60 years) with mild cognitive impairment (MCI).
  
  
  METHODS
  Elderly patients with MCI undergoing radical rectal resection were randomly assigned to receive sevoflurane or propofol general anaesthesia. Cognitive function was assessed using neuropsychological testing before and 7 days after surgery. POCD severity was graded as mild, moderate or severe using standard deviation cut-offs.
  
  
  RESULTS
  At 7 days after surgery, the incidence of POCD was 29.7% in the propofol group (n = 101) and 33.3% in the sevoflurane group (n = 99). There was a signiﬁcant between-group difference for POCD severity: sevoflurane anaesthesia had a more severe impact on cognitive function than propofol anaesthesia.
  
  
  CONCLUSIONS
  There was no difference in the incidence of POCD at 7 days after radical rectal resection under sevoflurane or propofol-based general anaesthesia. Both propofol and sevoflurane were associated with negative cognitive effects, but sevoflurane had a more severe impact on cognitive function than propofol, in elderly patients with MCI.
authors.affiliation: Department of Anaesthesia, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Ni
authors.initials: N
authors.lastname: Tang
authors.affiliation: Department of Anaesthesia, The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Cehua
authors.initials: C
authors.lastname: Ou
authors.affiliation: Department of Anaesthesia, The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Anaesthesia, West China Hospital, Sichuan University, Chengdu, China 1440167389@qq.com.
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Zuo
authors.affiliation: Department of Anaesthesia, The Affiliated Hospital of Luzhou Medical College, Luzhou, China.
authors.forename: Yipping
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D018685:Anesthetics, Inhalation / Q000009:adverse effects* / Q000627:therapeutic use; D018686:Anesthetics, Intravenous / Q000009:adverse effects* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects; D060825:Cognitive Dysfunction / Q000139:chemically induced* / Q000473:pathology; D013505:Digestive System Surgical Procedures / Q000009:adverse effects / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000523:psychology; D015742:Propofol / Q000009:adverse effects* / Q000627:therapeutic use; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D018686:Anesthetics, Intravenous; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol
keywords: Postoperative cognitive dysfunction; mild cognitive impairment; propofol; sevoflurane