title: An anatomically detailed arterial network model for one-dimensional computational hemodynamics.
abstract: Simulation platforms are increasingly becoming complementary tools for cutting-edge cardiovascular research. The interplay among structural properties of the arterial wall, morphometry, anatomy, wave propagation phenomena, and ultimately, cardiovascular diseases continues to be poorly understood. Accurate models are powerful tools to shed light on these open problems. We developed an anatomically detailed computational model of the arterial vasculature to conduct 1-D blood flow simulations to serve as simulation infrastructure to aid cardiovascular research. An average arterial vasculature of a man was outlined in 3-D space to serve as geometrical substrate for the mathematical model. The architecture of this model comprises almost every arterial vessel acknowledged in the medical/anatomical literature, with a resolution down to the luminal area of perforator arteries. Over 2000 arterial vessels compose the model. Anatomical, physiological, and mechanical considerations were employed for the set up of model parameters and to determine criteria for blood flow distribution. Computational fluid dynamics was used to simulate blood flow and wave propagation phenomena in such arterial network. A sensitivity analysis was developed to unveil the contributions of model parameters to the conformation of the pressure waveforms. In addition, parameters were modified to target model to a patient-specific scenario. On the light of the knowledge domain, we conclude that the present model features excellent descriptive and predictive capabilities in both patient-generic and patient-specific cases, presenting a new step toward integrating an unprecedented anatomical description, morphometric, and simulations data to help in understanding complex arterial blood flow phenomena and related cardiovascular diseases.
authors.forename: Pablo J
authors.initials: PJ
authors.lastname: Blanco
authors.forename: Sansuke M
authors.initials: SM
authors.lastname: Watanabe
authors.forename: Marco Aurélio R F
authors.initials: MA
authors.lastname: Passos
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Lemos
authors.forename: Raúl A
authors.initials: RA
authors.lastname: Feijóo
mesh_terms: D000328:Adult; D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D006801:Humans; D008297:Male; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D012039:Regional Blood Flow / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology