title: Oxidative cross-dehydrogenative coupling between N-aryl tetrahydroisoquinolins and 5H-oxazol-4-ones through two methodologies: copper catalysis or a metal-free strategy.
abstract: A direct oxidative cross-dehydrogenative coupling (CDC) of N-aryl tetrahydroisoquinolins with 5H-oxazol-4-ones catalyzed by CuBr using air as the only oxidant has been developed, which could also proceed smoothly under a metal-free oxidative system with PhI(OAc)2 as the oxidant. A series of alkylated tetrahydroisoquinolin derivatives were obtained in good yields and excellent diastereoselectivities.
authors.affiliation: State Key Laboratory of Chiroscience, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
authors.forename: Xihong
authors.initials: X
authors.lastname: Liu
authors.forename: Jinlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Shixiong
authors.initials: S
authors.lastname: Ma
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Ma
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D010081:Oxazolone / Q000737:chemistry*; D058451:Oxidative Coupling; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
chemical_list: D044005:Tetrahydroisoquinolines; D010081:Oxazolone; D003300:Copper