title: Association of genetic variation in the natriuretic peptide system and left ventricular mass and blood pressure in newborns.
abstract: BACKGROUND
  The natriuretic peptides play a key role in the modulation of left ventricular mass (LVM) and blood pressure (BP). We hypothesised that NPPA (natriuretic peptide precursor A gene), NPPB (natriuretic peptide precursor B gene), and NPPC (natriuretic peptide precursor C gene) are candidate genes possibly involved in the development or modulation of LVM at early life.
  
  
  OBJECTIVE
  To assess the relationship between NPPA, NPPB, and NPPC gene polymorphisms with LVM and BP in newborns.
  
  
  METHODS
  A total of 206 healthy newborns were studied by two-dimensional M-mode echocardiography. The polymorphisms NPPA rs5065, NPPB rs198389, and NPPC rs5268 were characterised.
  
  
  RESULTS
  Newborns carrying the C allele of the NPPB polymorphism had significantly lower LVM/body surface area (BSA) and LVM/body weight (BW) values when compared with newborns' homozygotes for the T allele (41.76 g/m2 vs. 48.31 g/m2, p adjusted = 0.044 and 2.78 g/kg vs. 3.26 g/kg, p adjusted = 0.031, respectively). An association was observed between NPPA genotype and systolic BP, diastolic BP, and mean arterial pressure ≥ 90th percentile (p = 0.029, p = 0.0048, p = 0.004, respectively). Also an association was observed for systolic BP ≥ 90th percentile for NPPB (p = 0.016).
  
  
  CONCLUSIONS
  The present study shows that the NPPB gene polymorphism is associated with modulation of LVM in newborns. The NPPA and NPPB gene polymorphisms are associated with BP.
authors.affiliation: Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland. igor@pum.edu.pl.
authors.forename: Iwona
authors.initials: I
authors.lastname: Gorący
authors.forename: Grażyna
authors.initials: G
authors.lastname: Dawid
authors.forename: Karolina
authors.initials: K
authors.lastname: Skonieczna-Żydecka
authors.forename: Mariusz
authors.initials: M
authors.lastname: Kaczmarczyk
authors.forename: Beata
authors.initials: B
authors.lastname: Łoniewska
authors.forename: Jarosław
authors.initials: J
authors.lastname: Gorący
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D004452:Echocardiography; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics / Q000378:metabolism*; D007231:Infant, Newborn; D008297:Male; D045265:Natriuretic Peptides / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D045265:Natriuretic Peptides