title: The influence of early life nutrition on epigenetic regulatory mechanisms of the immune system.
abstract: The immune system is exquisitely sensitive to environmental changes. Diet constitutes one of the major environmental factors that exerts a profound effect on immune system development and function. Epigenetics is the study of mitotically heritable, yet potentially reversible, molecular modifications to DNA and chromatin without alteration to the underlying DNA sequence. Nutriepigenomics is an emerging discipline examining the role of dietary influences on gene expression. There is increasing evidence that the epigenetic mechanisms that regulate gene expression during immune differentiation are directly affected by dietary factors or indirectly through modifications in gut microbiota induced by different dietary habits. Short-chain fatty acids, in particular butyrate, produced by selected bacteria stains within gut microbiota, are crucial players in this network.
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. lorella.paparo@alice.it.
authors.forename: Lorella
authors.initials: L
authors.lastname: Paparo
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. mara.dicostanzo@live.it.
authors.forename: Margherita
authors.initials: M
authors.lastname: di Costanzo
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. carmen91ds@alice.it.
authors.forename: Carmen
authors.initials: C
authors.lastname: di Scala
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. lindacosenza@libero.it.
authors.forename: Linda
authors.initials: L
authors.lastname: Cosenza
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. ludovicaleone@hotmail.it.
authors.forename: Ludovica
authors.initials: L
authors.lastname: Leone
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. ritanocerino@alice.it.
authors.forename: Rita
authors.initials: R
authors.lastname: Nocerino
authors.affiliation: Pediatric Food Allergy Unit, Department of Translational Medical Science, University of Naples Federico II, via S. Pansini 5, 80131 Naples, Italy. berni@unina.it.
authors.forename: Roberto Berni
authors.initials: RB
authors.lastname: Canani
mesh_terms: D002087:Butyrates / Q000378:metabolism; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D004032:Diet; D044127:Epigenesis, Genetic; D005232:Fatty Acids, Volatile / Q000008:administration & dosage; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D007107:Immune System / Q000502:physiology*; D064307:Microbiota; D054647:Nutrigenomics / Q000379:methods; D009752:Nutritional Status
chemical_list: D002087:Butyrates; D005232:Fatty Acids, Volatile