title: CD4 helpers put tissue-resident memory cells in their place.
abstract: The regulation of tissue-resident memory cell development is poorly understood. In this issue of Immunity, Laidlaw et al. (2014) demonstrate that CD4(+) T cells promote development of lung-resident memory cells by limiting T-bet expression and directing CD8(+) T cells to the airway epithelium.
authors.affiliation: The Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia.
authors.forename: Laura K
authors.initials: LK
authors.lastname: Mackay
authors.affiliation: The Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia. Electronic address: fcarbone@unimelb.edu.au.
authors.forename: Francis R
authors.initials: FR
authors.lastname: Carbone
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory; D053122:Influenza A Virus, H3N2 Subtype / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000096:biosynthesis*; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor