title: [Effects of the 520-day isolation on the functional state of the cardiovascular system].
abstract: Purpose of the work was to study the cardiovascular effects of simulated factors in a 520-day crewed mission to Mars, and to validate the diagnostic value of the ultrasonic investigation of microcirculation and endothelium-dependent dilation of the right brachial artery in 6 male volunteers at the age of 28 to 39 years. It appears that 520-d isolation affected intracardiac hemodynamics and endothelium function more dramatically compared with 105-d isolation, increasing the risk of atherosclerosis. These findings add insight into the "cost of human adaptation" to very long isolation.
authors.forename: G P
authors.initials: GP
authors.lastname: Stepanova
authors.forename: S P
authors.initials: SP
authors.lastname: Buĭlov
authors.forename: A I
authors.initials: AI
authors.lastname: Eshchenko
authors.forename: M A
authors.initials: MA
authors.lastname: Skedina
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Voronkov
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D050197:Atherosclerosis; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004452:Echocardiography; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006321:Heart / Q000503:physiopathology*; D018056:Hemorheology; D006801:Humans; D008297:Male; D012307:Risk Factors; D012934:Social Isolation; D014664:Vasodilation