title: Oxidative stress and antioxidative parameters in patients with spinal cord injury: implications in the pathogenesis of disease.
abstract: METHODS
  Oxygen-derived free radicals have been implicated in the pathogenesis of spinal cord injury (SCI) after trauma.
  
  
  OBJECTIVE
  In this review we will elucidate the importance of oxidative stress and antioxidants and its possible relationship with SCI.
  
  
  METHODS
  Literature analysis of oxidative stress, antioxidative parameters based on its implications in the pathogenesis along with devastating effect of oxidative stress parameters on SCI patients and its suggested proposed treatment by antioxidants have been performed.
  
  
  RESULTS
  SCI remains a major health problem despite advances in neurotechnology. Previous studies have reported oxidative stress in SCI patients, but the results were inconsistent. Furthermore, increased free radical levels are reported in SCI. Moreover, we have also mentioned in this review that oxidative stress is supposed to be increased in patients with SCI, which is related to the severity of SCI pain.
  
  
  CONCLUSIONS
  Oxidative stress was commonly seen in SCI patients, which may provide useful information to augment the understanding of pathophysiology of SCI patients. However, complete understanding of the biochemical events occurring at a cellular level that influence oxidative damage is required to guide future therapeutic advances. Furthermore, supplementation of antioxidants may also be considered in these patients.
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, India.
authors.forename: G
authors.initials: G
authors.lastname: Fatima
authors.affiliation: Department of Physical Medicine & Rehabilitation, King George's Medical University, Lucknow, India.
authors.forename: V P
authors.initials: VP
authors.lastname: Sharma
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Das
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, India.
authors.forename: A A
authors.initials: AA
authors.lastname: Mahdi
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D013119:Spinal Cord Injuries / Q000378:metabolism* / Q000503:physiopathology*
chemical_list: D000975:Antioxidants