title: Modelling and subject-specific validation of the heart-arterial tree system.
abstract: A modeling approach integrated with a novel subject-specific characterization is here proposed for the assessment of hemodynamic values of the arterial tree. A 1D model is adopted to characterize large-to-medium arteries, while the left ventricle, aortic valve and distal micro-circulation sectors are described by lumped submodels. A new velocity profile and a new formulation of the non-linear viscoelastic constitutive relation suitable for the {Q, A} modeling are also proposed. The model is firstly verified semi-quantitatively against literature data. A simple but effective procedure for obtaining subject-specific model characterization from non-invasive measurements is then designed. A detailed subject-specific validation against in vivo measurements from a population of six healthy young men is also performed. Several key quantities of heart dynamics-mean ejected flow, ejection fraction, and left-ventricular end-diastolic, end-systolic and stroke volumes-and the pressure waveforms (at the central, radial, brachial, femoral, and posterior tibial sites) are compared with measured data. Mean errors around 5 and 8%, obtained for the heart and arterial quantities, respectively, testify the effectiveness of the model and its subject-specific characterization.
authors.affiliation: DIATI, Politecnico di Torino, Turin, Italy, andrea.guala@polito.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Guala
authors.forename: Carlo
authors.initials: C
authors.lastname: Camporeale
authors.forename: Francesco
authors.initials: F
authors.lastname: Tosello
authors.forename: Claudio
authors.initials: C
authors.lastname: Canuto
authors.forename: Luca
authors.initials: L
authors.lastname: Ridolfi
mesh_terms: D000328:Adult; D001158:Arteries / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D066230:Patient-Specific Modeling; D015203:Reproducibility of Results; D055815:Young Adult