title: Dry age-related macular degeneration: A currently unmet clinical need.
abstract: Age-related macular degeneration (AMD) is a leading cause of severe visual impairment and disability in older people worldwide. Although considerable advances in the management of the neovascular form of AMD have been made in the last decade, no therapy is yet available for the advanced dry form of AMD (geographic atrophy). This review focuses on current trends in the development of new therapies targeting specific pathophysiological pathways of dry AMD. Increased understanding of the complex mechanisms that underlie dry AMD will help to address this largely unmet clinical need.
authors.affiliation: French National Institute of Health and Medical Research, Paris, France; ; Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France;
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Girmens
authors.affiliation: French National Institute of Health and Medical Research, Paris, France; ; French Academy of Sciences, Paris, France.
authors.forename: José-Alain
authors.initials: JA
authors.lastname: Sahel
authors.affiliation: French National Institute of Health and Medical Research, Paris, France; ; National Center for Scientific Research, Paris, France;
authors.forename: Katia
authors.initials: K
authors.lastname: Marazova
keywords: Age-related macular degeneration; clinical trials; degeneration; dry age-related macular; geographic atrophy; treatment