title: Enantioselective synthesis of arylglycine derivatives by direct C-H oxidative cross-coupling.
abstract: A new method for the synthesis of chiral α-amino acid derivatives by enantioselective C-H arylation of N-aryl glycine esters with aryl boric acids in the presence of a chiral Pd(II)-catalyst has been developed. This work successfully integrates the direct C-H oxidation with asymmetric arylation and exhibits excellent enantioselectivity.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China. yangshd@lzu.edu.cn.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wei
authors.forename: Gang-Wei
authors.initials: GW
authors.lastname: Wang
authors.forename: Shang-Dong
authors.initials: SD
authors.lastname: Yang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D002244:Carbon; D006859:Hydrogen; D005998:Glycine