title: Are natural killer cells superior CAR drivers?
abstract: T lymphocytes engineered to express a chimeric antigen receptor (CAR) are being celebrated as a major breakthrough of anticancer immunotherapy. Natural killer cells have not received similar attention as CAR effectors, although the use of these relatively short-lived cytotoxic cells is associated with several advantages.
authors.affiliation: Tufts University School of Medicine; Boston, MA USA ; Conkwest Inc.; Cambridge, MA USA.
authors.forename: Hans
authors.initials: H
authors.lastname: Klingemann
keywords: CAR; NK cells; NK-92 cells; T lymphocytes; cancer; on-target/off-tumor effect