title: Effect of Salvia officinalis on diabetic patients.
abstract: BACKGROUND
  Herbs are rich sources of natural antioxidants, and are used in traditional medicine for the control and treatment of many diseases. The reducing effect of a large number of these plants on blood glucose has been approved in animal models and clinical studies.
  
  
  OBJECTIVE
  This study was therefore, performed to investigate the hypoglycemic effect of Salvia officinalis on blood glucose, Glycosylated hemoglobin (HbA1c), lipid profile, liver and kidney function tests.
  
  
  METHODS
  A double-blind clinical trial was carried out on 80 type II diabetic patients who had not reached the ideal control of the disease. Patients were randomly divided into two equal groups of case and control. The case group received Salvia officinalis and the control group received placebo tablets three times a day for three months. The fasting blood sugar (FBS) and 2 hours postprandial (2hpp) glucose were checked at the beginning and every 2 weeks, for three months Glycosylated hemoglobin (HbA1c), lipid profile, liver and kidney function tests were also measured at the beginning and at the end of trial and compared in two mentioned groups.
  
  
  RESULTS
  The 2hpp blood sugar and cholesterol levels were significantly decreased in Salvia officinalis treated patients compared to control group (p<0.05). There were no significant changes in glycosylated hemoglobin and FBS between the two groups.
  
  
  CONCLUSIONS
  RESULTS showed that Salvia officinalis might be beneficial in diabetic patients to reduce 2hpp and cholesterol. However higher doses might be needed to decrease fasting blood glucose and glycosylated hemoglobin.
authors.affiliation: Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Behradmanesh
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Derees
authors.affiliation: Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Rafieian-Kopaei
keywords: Diabetic nephropathy; Sage; Salvia officinalis