title: Multicentric study in five African countries of antibiotic susceptibility for three main pathogens: Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa.
abstract: Antibiotic resistance is a growing clinical and epidemiological problem. We report on the antibiotic susceptibility of three pathogens isolated from patients in Algeria, Egypt, Morocco, Senegal, and Tunisia during 2010-2011. In total, 218 Streptococcus pneumoniae, 428 Staphylococcus aureus, and 414 Pseudomonas aeruginosa strains were collected. S. pneumoniae resistance was noted against penicillin (30.2%), erythromycin (27.4%), cefpodoxime (19.1%), amoxicillin (12.0%), cefotaxime (7.4%), and levofloxacin (3.2%). All the strains were teicoplanin susceptible. Staphylococcus aureus methicillin resistance differed between countries, from 5.0% in Senegal to 62.7% in Egypt. Levofloxacin resistance was low in all countries, and the highest rate (in Egypt) was still only 13.6% for intermediate and resistant strains combined. Most strains were susceptible to fosfomycin (99.3%) and pristinamycin (94.2%). P. aeruginosa resistance was found against levofloxacin (30.4%), ciprofloxacin (29.9%), tobramycin (19.7%), ceftazidime (19.2%), and imipenem (17.9%), but not colistin. Antibiotic susceptibility varied widely between countries, with resistance typically most prevalent in Egypt.
authors.affiliation: a Laboratoire de Microbiologie , CHU Ibn Rochd, Faculté de Médecine et de Pharmacie de Casablanca , Casablanca , Morocco.
authors.forename: Khalid
authors.initials: K
authors.lastname: Zerouali
authors.affiliation: b Department of Microbiology , University Hospital of Mustapha Bacha , Alger , Algeria.
authors.forename: Nadjia
authors.initials: N
authors.lastname: Ramdani-Bouguessa
authors.affiliation: c Microbiology, Faculty of Medecine , Cheikh Anta Diop University , Dakar , Senegal.
authors.forename: Cheikh
authors.initials: C
authors.lastname: Boye
authors.affiliation: d Department of Microbiology , Habib Bourguiba University.
authors.forename: Adnane
authors.initials: A
authors.lastname: Hammami
mesh_terms: D000328:Adult; D000349:Africa / Q000453:epidemiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D013296:Streptococcus pneumoniae / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antibiotic resistance; Antibiotic susceptibility; Multicenter study; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus pneumoniae