title: Gold nanoparticles functionalized with cresyl violet and porphyrin via hyaluronic acid for targeted cell imaging and phototherapy.
abstract: Gold nanoparticles are functionalized as a nanoprobe with cresyl violet and porphyrin via hyaluronic acid. The nanoprobe becomes highly fluorescent in the presence of hyaluronidase or under ultraviolet irradiation, and can be used to target cancer cells via the overexpressed CD44 receptor for fluorescence imaging and phototherapy.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. mahm@iccas.ac.cn.
authors.forename: Yanchao
authors.initials: Y
authors.lastname: Song
authors.forename: Zhe
authors.initials: Z
authors.lastname: Wang
authors.forename: Lihong
authors.initials: L
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Shi
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Li
authors.forename: Huimin
authors.initials: H
authors.lastname: Ma
mesh_terms: D000818:Animals; D048588:Benzoxazines / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D018960:Hyaluronan Receptors / Q000737:chemistry / Q000378:metabolism; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000378:metabolism; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D010789:Phototherapy; D011166:Porphyrins / Q000737:chemistry*; D026082:Singlet Oxygen / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D048588:Benzoxazines; D018960:Hyaluronan Receptors; D011166:Porphyrins; D026082:Singlet Oxygen; C028911:cresyl violet; D006046:Gold; D006820:Hyaluronic Acid; D006821:Hyaluronoglucosaminidase