title: Evaluation of Nerve Conduction Studies in Obese Children With Insulin Resistance or Impaired Glucose Tolerance.
abstract: The aim of the study was to investigate nerve conduction studies in terms of neuropathic characteristics in obese patients who were in prediabetes stage and also to determine the abnormal findings. The study included 69 obese adolescent patients between April 2009 and December 2010. All patients and control group underwent motor (median, ulnar, tibial, and peroneal) and sensory (median, ulnar, sural, and medial plantar) nerve conduction studies and sympathetic skin response test. Sensory response amplitude of the medial plantar nerve was significantly lower in the patients with impaired glucose tolerance and insulin resistance. To our knowledge, the present study is the first study demonstrating the development of sensory and autonomic neuropathy due to metabolic complications of obesity in adolescent children even in the period without development of diabetes mellitus. We recommend that routine electrophysiological examinations be performed, using medial plantar nerve conduction studies and sympathetic skin response test.
authors.affiliation: Department of Pediatric Neurology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey drhulyaince@yahoo.com.
authors.forename: Hülya
authors.initials: H
authors.lastname: Ince
authors.affiliation: Department of Pediatric Neurology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Haydar Ali
authors.initials: HA
authors.lastname: Taşdemir
authors.affiliation: Department of Pediatric Endocrinology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Aydin
authors.affiliation: Department of Pediatric Neurology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Hamit
authors.initials: H
authors.lastname: Ozyürek
authors.affiliation: Department of Neurology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Hacer Erdem
authors.initials: HE
authors.lastname: Tilki
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D004558:Electric Stimulation; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D009460:Neurologic Examination; D009765:Obesity / Q000097:blood* / Q000503:physiopathology*; D010525:Peripheral Nerves / Q000503:physiopathology*; D011930:Reaction Time
chemical_list: D001786:Blood Glucose; D002784:Cholesterol
keywords: children; impaired glucose tolerance; insulin resistance; obesity; peripheric neuropathy; sympathetic skin response