title: Role of renal oxygenation and mitochondrial function in the pathophysiology of acute kidney injury.
abstract: There are unique features of renal oxygenation that render the kidney susceptible to oxygen demand-supply mismatch and hypoxia. Renal oxygen consumption by oxidative metabolism is closely coupled to and driven by tubular transport, which is linked to the filtered solute load and glomerular filtration rate (GFR). In turn, filtered solute load and GFR are dependent on the renal blood flow. Hence, changes in renal blood flow increase oxygen delivery but also increase oxygen demand (consumption) simultaneously by increasing the tubular workload of solute transport. The renal blood flow to different regions of kidney is also inhomogeneous, increasing the oxygen demand-supply mismatch in particular areas such as the outer medulla which become more susceptible to injury. Thus, tubular transport and oxidative metabolism by miochondria are closely coupled in the kidney and are the principal determinants of intrarenal oxygenation. Here we review the published literature characterizing renal oxygenation and mitochondrial function in ischemic and sepsis-associated acute kidney injury (AKI). However, the coupling of transport and metabolism in AKI has not been examined. This is a potentially fruitful area of research that should become increasingly active given the emerging data linking renal oxygenation and hypoxia to acute and chronic dysfunction in the kidney.
authors.affiliation: Division of Nephrology-Hypertension, University of California San Diego School of Medicine, and VA San Diego Healthcare System, San Diego, Calif., USA.
authors.forename: Noureddin
authors.initials: N
authors.lastname: Nourbakhsh
authors.forename: Prabhleen
authors.initials: P
authors.lastname: Singh
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D001692:Biological Transport; D015687:Cell Hypoxia; D004195:Disease Models, Animal; D004734:Energy Metabolism; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology*; D063154:Mitochondrial Dynamics; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010101:Oxygen Consumption; D012079:Renal Circulation; D015427:Reperfusion Injury / Q000378:metabolism; D018805:Sepsis / Q000150:complications / Q000503:physiopathology; D012964:Sodium / Q000378:metabolism; D014661:Vasoconstriction
chemical_list: D012964:Sodium; D010100:Oxygen