title: Delayed development of neural language organization in very preterm born children.
abstract: This study investigates neural language organization in very preterm born children compared to control children and examines the relationship between language organization, age, and language performance. Fifty-six preterms and 38 controls (7-12 y) completed a functional magnetic resonance imaging language task. Lateralization and signal change were computed for language-relevant brain regions. Younger preterms showed a bilateral language network whereas older preterms revealed left-sided language organization. No age-related differences in language organization were observed in controls. Results indicate that preterms maintain atypical bilateral language organization longer than term born controls. This might reflect a delay of neural language organization due to very premature birth.
authors.affiliation: a Division of Neuropediatrics, Development and Rehabilitation , Children's University Hospital , Inselspital , Bern , Switzerland.
authors.forename: Ines
authors.initials: I
authors.lastname: Mürner-Lavanchy
authors.forename: Maja
authors.initials: M
authors.lastname: Steinlin
authors.forename: Claus
authors.initials: C
authors.lastname: Kiefer
authors.forename: Christian
authors.initials: C
authors.lastname: Weisstanner
authors.forename: Barbara Catherine
authors.initials: BC
authors.lastname: Ritter
authors.forename: Walter
authors.initials: W
authors.lastname: Perrig
authors.forename: Regula
authors.initials: R
authors.lastname: Everts
mesh_terms: D001921:Brain / Q000254:growth & development / Q000502:physiology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D002658:Developmental Disabilities; D005260:Female; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D062071:Infant, Extremely Premature / Q000502:physiology*; D007231:Infant, Newborn; D007802:Language; D007804:Language Development; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000473:pathology*; D011247:Pregnancy; D047928:Premature Birth