title: Caffeic Acid Phenethyl Ester: A Review of Its Antioxidant Activity, Protective Effects against Ischemia-reperfusion Injury and Drug Adverse Reactions.
abstract: Propolis, a honey bee product, has been used in folk medicine for centuries for the treatment of abscesses, canker sores and for wound healing. Caffeic acid phenethyl ester (CAPE) is one of the most extensively investigated active components of propolis which possess many biological activities, including antibacterial, antiviral, antioxidant, anti-inflammatory, and anti-cancer effects. CAPE is a polyphenolic compound characterized by potent antioxidant and cytoprotective activities and protective effects against ischemia-reperfusion (I/R)-induced injury in multiple tissues such as brain, retina, heart, skeletal muscles, testis, ovaries, intestine, colon, and liver. Furthermore, several studies indicated the protective effects of CAPE against chemotherapy-induced adverse drug reactions (ADRs) including several antibiotics (streptomycin, vancomycin, isoniazid, ethambutol) and chemotherapeutic agents (mitomycin, doxorubicin, cisplatin, methotrexate). Due to the broad spectrum of pharmacological activities of CAPE, this review makes a special focus on the recently published data about CAPE antioxidant activity as well as its protective effects against I/R-induced injury and many adverse drug reactions.
authors.affiliation: a Faculty of Pharmacy, Department of Pharmacology and Toxicology, Ain Shams University , Cairo , Egypt.|b Department of Obstetrics and Gynecology , The University of Texas Medical Branch , Galveston , Texas , USA.
authors.forename: Mai F
authors.initials: MF
authors.lastname: Tolba
authors.affiliation: c Faculty of Pharmacy, Department of Pharmacology, Beni-Suef University , Egypt.
authors.forename: Hany A
authors.initials: HA
authors.lastname: Omar
authors.affiliation: a Faculty of Pharmacy, Department of Pharmacology and Toxicology, Ain Shams University , Cairo , Egypt.
authors.forename: Samar S
authors.initials: SS
authors.lastname: Azab
authors.affiliation: a Faculty of Pharmacy, Department of Pharmacology and Toxicology, Ain Shams University , Cairo , Egypt.
authors.forename: Amani E
authors.initials: AE
authors.lastname: Khalifa
authors.affiliation: a Faculty of Pharmacy, Department of Pharmacology and Toxicology, Ain Shams University , Cairo , Egypt.
authors.forename: Ashraf B
authors.initials: AB
authors.lastname: Abdel-Naim
authors.affiliation: b Department of Obstetrics and Gynecology , The University of Texas Medical Branch , Galveston , Texas , USA.
authors.forename: Sherif Z
authors.initials: SZ
authors.lastname: Abdel-Rahman
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects; D000975:Antioxidants; D002109:Caffeic Acids / Q000737:chemistry / Q000627:therapeutic use*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000517:prevention & control*; D006801:Humans; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D011429:Propolis / Q000737:chemistry*; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D002109:Caffeic Acids; D011429:Propolis; C055494:caffeic acid phenethyl ester; D010626:Phenylethyl Alcohol
keywords: Antioxidant; caffeic acid phenethyl ester (CAPE); chemistry; ischemia/reperfusion (I/R)