title: Endophytic fungi with antitumor activities: Their occurrence and anticancer compounds.
abstract: Plant endophytic fungi have been recognized as an important and novel resource of natural bioactive products, especially in anticancer application. This review mainly deals with the research progress on the production of anticancer compounds by endophytic fungi between 1990 and 2013. Anticancer activity is generally associated with the cytotoxicity of the compounds present in the endophytic fungi. All strains of endophytes producing antitumor chemicals were classified taxonomically and the genera of Pestalotiopsis and Aspergillus as well as the taxol producing endophytes were focused on. Classification of endophytic fungi producing antitumor compounds has received more attention from mycologists, and it can also lead to the discovery of novel compounds with antitumor activity due to phylogenetic relationships. In this review, the structures of the anticancer compounds isolated from the newly reported endophytes between 2010 and 2013 are discussed including strategies for the efficient production of the desired compounds. The purpose of this review is to provide new directions in endophytic fungi research including integrated information relating to its anticancer compounds.
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Qiao-Yan
authors.initials: QY
authors.lastname: Zhang
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Min
authors.initials: M
authors.lastname: Jia
authors.affiliation: b Department of Pharmacognosy , School of Pharmacy, Third Military Medical University , Chongqing , China and.
authors.forename: Qian-Liang
authors.initials: QL
authors.lastname: Ming
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Wei
authors.initials: W
authors.lastname: Yue
authors.affiliation: c Faculty of Science , School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University , Liverpool , UK.
authors.forename: Khalid
authors.initials: K
authors.lastname: Rahman
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Second Military Medical University , Shanghai , China .
authors.forename: Ting
authors.initials: T
authors.lastname: Han
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D060026:Endophytes / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000737:chemistry* / Q000145:classification / Q000235:genetics / Q000378:metabolism; D006801:Humans; D010802:Phylogeny; D010944:Plants / Q000382:microbiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic
keywords: Anticancer activity; Aspergillus; Pestalotiopsis; bioactive metabolite; endophyte; medicinal plant