title: The serum lipid profile of Parkinson's disease patients: a study from China.
abstract: BACKGROUND
  The association between the fasting levels of serum lipids and Parkinson's disease (PD) in Chinese populations remains largely unknown.
  
  
  METHODS
  This study enrolled 555 sporadic PD patients and 555 age-, gender- and body mass index (BMI)-matched controls. The fasting serum lipid concentrations of all subjects, including total cholesterol, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and triglycerides (TG), were measured.
  
  
  RESULTS
  Total cholesterol, LDL-C, HDL-C and TG were significantly lower in PD patients than in controls. The prevalence of PD is significantly lower in subjects with the second, third and fourth quartiles of total cholesterol than in those with the first quartile of total cholesterol, regardless of gender. The prevalence of PD is significantly lower in subjects with the third and fourth quartiles of LDL-C than in those with the first quartile of LDL-C, regardless of gender. Negative correlations were found between UPDRS part III score and level of total cholesterol/LDL-C.
  
  
  CONCLUSIONS
  PD patients are with lower levels of total cholesterol, LDL-C, HDL-C and TG than controls. Lipids may be a marker of PD severity.
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Guo
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Ke
authors.initials: K
authors.lastname: Chen
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: XuePing
authors.initials: X
authors.lastname: Chen
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Zheng
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Bei
authors.initials: B
authors.lastname: Cao
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Rui
authors.initials: R
authors.lastname: Huang
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Bi
authors.initials: B
authors.lastname: Zhao
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wu
authors.affiliation: a Department of Neurology, West China Hospital, SiChuan University , Chengdu , Sichuan , China.
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Shang
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol
keywords: Parkinson's disease; cholesterol; high density lipoprotein cholesterol; low density lipoprotein cholesterol; serum lipid; triglyceride