title: 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
abstract: With increasing numbers of people with Alzheimer's and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer's Project Act, signed into law in 2011, required the creation of such a plan with annual updates thereafter. Pursuant to this, the US Department of Health and Human Services (HHS) released the National Plan to Address Alzheimer's Disease in 2012, including an ambitious research goal of preventing and effectively treating Alzheimer's disease by 2025. To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HHS also incorporated into the plan a set of short, medium and long-term milestones. HHS further committed to updating these milestones on an ongoing basis to account for progress and setbacks, and emerging opportunities and obstacles. To assist HHS as it updates these milestones, the Alzheimer's Association convened a National Plan Milestone Workgroup consisting of scientific experts representing all areas of Alzheimer's and dementia research. The workgroup evaluated each milestone and made recommendations to ensure that they collectively constitute an adequate work plan for reaching the goal of preventing and effectively treating Alzheimer's by 2025. This report presents these Workgroup recommendations.
authors.affiliation: Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL.
authors.forename: Keith N
authors.initials: KN
authors.lastname: Fargo
authors.affiliation: Department of Neurosciences, University of California San Diego School of Medicine, San Diego, CA.
authors.forename: Paul
authors.initials: P
authors.lastname: Aisen
authors.affiliation: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Albert
authors.affiliation: Department of Neurology and Framingham Heart Study, Boston University School of Medicine, Boston, MD.
authors.forename: Rhoda
authors.initials: R
authors.lastname: Au
authors.affiliation: Department of Neurology and Department of Epidemiology, University of California, Irvine, CA.
authors.forename: Maria M
authors.initials: MM
authors.lastname: Corrada
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, VA; Department of Radiology and Department of Neurology, University of Pittsburgh, PA.
authors.forename: Steven
authors.initials: S
authors.lastname: DeKosky
authors.affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, MA.
authors.forename: David
authors.initials: D
authors.lastname: Drachman
authors.affiliation: Alzheimer's Drug Discovery Foundation; Department of Geriatrics and Palliative Medicine and Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY.
authors.forename: Howard
authors.initials: H
authors.lastname: Fillit
authors.affiliation: Department of Community-Public Health and Department of Psychiatry, Johns Hopkins University, Baltimore, MD.
authors.forename: Laura
authors.initials: L
authors.lastname: Gitlin
authors.affiliation: Orion Bionetworks, Cambridge, MA.
authors.forename: Magali
authors.initials: M
authors.lastname: Haas
authors.affiliation: Division of Life Science and the State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Kowloon, Hong Kong.
authors.forename: Karl
authors.initials: K
authors.lastname: Herrup
authors.affiliation: Department of Neurology, Department of Neurobiology & Behavior, and Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kawas
authors.affiliation: National Biomedical Research Ethics Council, Rockville, MD.
authors.forename: Ara S
authors.initials: AS
authors.lastname: Khachaturian
authors.affiliation: PAD2020, Rockville, MD.
authors.forename: Zaven S
authors.initials: ZS
authors.lastname: Khachaturian
authors.affiliation: Department of Psychiatry, University of Pittsburgh, PA.
authors.forename: William
authors.initials: W
authors.lastname: Klunk
authors.affiliation: Department of Neurology, Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN.
authors.forename: David
authors.initials: D
authors.lastname: Knopman
authors.affiliation: National Alzheimer's Coordinating Center (NACC); and Department of Epidemiology, University of Washington, Seattle, WA.
authors.forename: Walter A
authors.initials: WA
authors.lastname: Kukull
authors.affiliation: Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic, Cleveland, OH.
authors.forename: Bruce
authors.initials: B
authors.lastname: Lamb
authors.affiliation: Department of Psychosocial and Community Health, University of Washington, Seattle, WA.
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Logsdon
authors.affiliation: Florey Institute for Neuroscience and Mental Health, University of Melbourne; and CogState Ltd., Melbourne VIC, Australia.
authors.forename: Paul
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authors.lastname: Maruff
authors.affiliation: Department of Neurology and Alzheimer's Disease Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
authors.forename: Marsel
authors.initials: M
authors.lastname: Mesulam
authors.affiliation: Department of Neurosciences, University of California San Diego School of Medicine, San Diego, CA.
authors.forename: William
authors.initials: W
authors.lastname: Mobley
authors.affiliation: Neuroscience Early Clinical Development, Eli Lilly and Company, Indianapolis, IN.
authors.forename: Richard
authors.initials: R
authors.lastname: Mohs
authors.affiliation: Byrd Alzheimer's Institute, University of South Florida, Tampa, FL.
authors.forename: David
authors.initials: D
authors.lastname: Morgan
authors.affiliation: Department of Psychiatry and Department of Cell Biology, New York University Langone Medical Center, New York, NY; and The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY.
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Nixon
authors.affiliation: Appel Alzheimer's Disease Research Institute, Weill Cornell Medical College, New York, NY; Foundation for the National Institutes of Health, Bethesda, MD.
authors.forename: Steven
authors.initials: S
authors.lastname: Paul
authors.affiliation: Department of Neurology, Mayo Clinic Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN.
authors.forename: Ronald
authors.initials: R
authors.lastname: Petersen
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC.
authors.forename: Brenda
authors.initials: B
authors.lastname: Plassman
authors.affiliation: Neuroscience Steering Committee of the Biomarkers Consortium, Foundation of the National Institutes of Health (emeritus).
authors.forename: William
authors.initials: W
authors.lastname: Potter
authors.affiliation: Banner Alzheimer's Institute; and Department of Psychiatry, University of Arizona College of Medicine, Phoenix, AZ.
authors.forename: Eric
authors.initials: E
authors.lastname: Reiman
authors.affiliation: Department of Psychiatry, New York University School of Medicine, New York, NY.
authors.forename: Barry
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authors.lastname: Reisberg
authors.affiliation: Department of Psychiatry; and Alzheimer's Disease Research Center, Mount Sinai School of Medicine, New York, NY.
authors.forename: Mary
authors.initials: M
authors.lastname: Sano
authors.affiliation: Pfizer, Inc., New York, NY.
authors.forename: Rachel
authors.initials: R
authors.lastname: Schindler
authors.affiliation: Department of Psychiatry and the Behavioral Sciences and Department of Neurology, Keck School of Medicine; and Leonard Davis School of Gerontology; University of Southern California, Los Angeles, CA.
authors.forename: Lon S
authors.initials: LS
authors.lastname: Schneider
authors.affiliation: Department of Neurology, Alpert Medical School of Brown University; and Department of Neurology, Rhode Island Hospital; Providence, RI.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Snyder
authors.affiliation: Departments of Neurology, Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA.
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.affiliation: Department of Psychiatry and Department of Neurology, University of California, San Francisco; and San Francisco VA Medical Center, CA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.affiliation: Independent Science Writer, Elverson, PA.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Bain
authors.affiliation: Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL.
authors.forename: William H
authors.initials: WH
authors.lastname: Thies
authors.affiliation: Division of Medical and Scientific Relations, Alzheimer's Association, Chicago, IL. Electronic address: mcarrillo@alz.org.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control* / Q000628:therapy*; D000818:Animals; D064229:Biological Ontologies; D015415:Biomarkers / Q000378:metabolism; D055808:Drug Discovery; D006291:Health Policy; D006801:Humans; D018579:Patient Selection; D055818:Public-Private Sector Partnerships; D057170:Translational Research, Biomedical / Q000379:methods; D014481:United States; D014483:United States Dept. of Health and Human Services; D014837:Voluntary Health Agencies
chemical_list: D015415:Biomarkers
keywords: Milestones; National Plan to Address Alzheimer's Disease; Policy