title: What is the impact of tumour size on dermoscopic diagnosis of BCC?
abstract: BACKGROUND
  The effect of size on diagnostic performance of dermoscopy in basal cell carcinomas (BCCs) is yet to be determined.
  
  
  OBJECTIVE
  To investigate the differences in dermoscopic features between small- and large-sized BCCs.
  
  
  METHODS
  A total of 151 BCCs consecutively collected during a 2-year period were analysed. These tumours were evaluated for the presence of various dermoscopic features (colours, structures and vessels) using the contact polarized dermoscopy. Differences in proportions were evaluated by means of chi-squared test and Fisher's exact test, when appropriate.
  
  
  RESULTS
  In all, 62 (41.1%) small (≤ 1 cm) and 89 (58.9%) large (>1 cm) BCCs were included. Arborizing vessels, short fine telangiectasias (SFT) and multiple small erosions were significantly (P < 0.05) more frequent in the group of large BCCs. Further analysis of the effect of size on dermoscopic features within the specific groups, nodular, superficial and ulcerated, found significant difference only in the group of nodular BCCs. Structureless hypopigmentation was significantly (P < 0.05) more frequent in the group of large nodular BCCs in comparison with the small ones.
  
  
  CONCLUSIONS
  Despite determined differences in vascular features and multiple erosions between the small and large BCCs, the results of further investigation within the specific groups indicate that dermoscopy is reliable for the diagnosis of BCC regardless of its size.
authors.affiliation: Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia.
authors.forename: M
authors.initials: M
authors.lastname: Popadić
authors.affiliation: Clinic of Dermatovenereology, Clinical Centre of Serbia, Belgrade, Serbia.|Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: J
authors.initials: J
authors.lastname: Vukićević
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology*; D046169:Dermoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D012878:Skin Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology*; D047368:Tumor Burden