title: Neuroinflammation in Parkinson's disease: role in neurodegeneration and tissue repair.
abstract: Neuroinflammation in Parkinson's disease [PD] is a process that occurs alongside the loss of dopaminergic neurons, and is associated with alterations to many cell types, most notably microglia. This review examines the key evidence contributing to our understanding of the role of inflammation-mediated degeneration of the dopaminergic (DA) nigrostriatal pathway in PD. It will consider the potential role inflammation plays in tissue repair within the brain, inflammation linked gene products that are associated with sporadic Parkinsonian phenotypes (alpha-synuclein, Parkin and Nurr 1), and developing anti-inflammatory drug treatments in PD. With growing evidence supporting the key role of neuroinflammation in PD pathogenesis, new molecular targets are being found that could potentially prevent or delay nigrostriatal DA neuron loss. Hence, this creates the opportunity for disease modifying treatment, to currently what is an incurable disease.
authors.affiliation: a Imperial College School of Medicine, Imperial College London, Exhibition Road, London , United Kingdom.
authors.forename: Sayinthen
authors.initials: S
authors.lastname: Vivekanantham
authors.forename: Savan
authors.initials: S
authors.lastname: Shah
authors.forename: Rizwan
authors.initials: R
authors.lastname: Dewji
authors.forename: Abbas
authors.initials: A
authors.lastname: Dewji
authors.forename: Chetan
authors.initials: C
authors.lastname: Khatri
authors.forename: Rele
authors.initials: R
authors.lastname: Ologunde
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology / Q000502:physiology*; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000473:pathology*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D017628:Microglia / Q000378:metabolism; D009410:Nerve Degeneration / Q000188:drug therapy / Q000473:pathology*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents
keywords: Parkinson's disease; ageing; alpha-synuclein; dopamine; inflammation; microglia; neuroinflammation; nigrostriatal