title: Serological misdiagnosis of acute liver failure associated with echovirus 25 due to immunological similarities to hepatitis A virus and prozone effect.
abstract: We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Susan K
authors.initials: SK
authors.lastname: Wollersheim
authors.affiliation: Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Romney M
authors.initials: RM
authors.lastname: Humphries
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Cherry
authors.affiliation: Department of Pediatrics, Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USA pkrogstad@mednet.ucla.edu.
authors.forename: Paul
authors.initials: P
authors.lastname: Krogstad
mesh_terms: D002675:Child, Preschool; D003951:Diagnostic Errors; D004457:Echovirus Infections / Q000175:diagnosis / Q000821:virology; D029822:Enterovirus B, Human / Q000276:immunology / Q000302:isolation & purification; D030041:Hepatitis A virus / Q000276:immunology*; D006801:Humans; D007118:Immunoassay; D017114:Liver Failure, Acute / Q000175:diagnosis / Q000821:virology; D008297:Male; D012698:Serologic Tests