title: Periplasmic Binding Proteins in Thermophiles: Characterization and Potential Application of an Arginine-Binding Protein from Thermotoga maritima: A Brief Thermo-Story.
abstract: Arginine-binding protein from the extremophile Thermotoga maritima is a 27.7 kDa protein possessing the typical two-domain structure of the periplasmic binding proteins family. The protein is characterized by a very high specificity and affinity to bind to arginine, also at high temperatures. Due to its features, this protein could be taken into account as a potential candidate for the design of a biosensor for arginine. It is important to investigate the stability of proteins when they are used for biotechnological applications. In this article, we review the structural and functional features of an arginine-binding protein from the extremophile Thermotoga maritima with a particular eye on its potential biotechnological applications.
authors.affiliation: Laboratory for Molecular Sensing, Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, Napoli, 80131, Italy. a.ausili@ibp.cnr.it.
authors.forename: Alessio
authors.initials: A
authors.lastname: Ausili
authors.affiliation: Laboratory for Molecular Sensing, Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, Napoli, 80131, Italy. m.staiano@ibp.cnr.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Staiano
authors.affiliation: Department of Chemistry, University of Richmond, Richmond, VA 23173, USA. jdattelb@richmond.edu.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Dattelbaum
authors.affiliation: Laboratory for Molecular Sensing, Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, Napoli, 80131, Italy. a.varriale@ibp.cnr.it.
authors.forename: Antonio
authors.initials: A
authors.lastname: Varriale
authors.affiliation: Laboratory for Molecular Sensing, Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, Napoli, 80131, Italy. a.capo@ibp.cnr.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Capo
authors.affiliation: Laboratory for Molecular Sensing, Institute of Protein Biochemistry, CNR, Via Pietro Castellino, 111, Napoli, 80131, Italy. s.dauria@ibp.cnr.it.
authors.forename: Sabato
authors.initials: S
authors.lastname: D'Auria