title: Amphidinins C-F, amphidinolide Q analogues from marine dinoflagellate Amphidinium sp.
abstract: Four new polyketides, amphidinins C-F (1-4), have been isolated from the culture broth of symbiotic dinoflagellate Amphidinium sp. The analysis of their spectral data revealed that amphidinins C-F (1-4) were 4,5-seco-analogues of amphidinolide Q (5). The absolute configurations of the new compounds were elucidated by the combination of J-based configuration analysis, modified Mosher's method, and chemical derivatization. Amphidinins D (2) and F (4) are the first glycosides related to amphidinolides. Amphidinins C-F (1-4) showed antimicrobial activity against bacteria and/or fungi.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University , Sapporo 060-0812, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Takahiro
authors.initials: T
authors.lastname: Iwai
authors.forename: Kanae
authors.initials: K
authors.lastname: Sakai
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004141:Dinoflagellida / Q000737:chemistry* / Q000302:isolation & purification; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D061065:Polyketides / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D000890:Anti-Infective Agents; D018942:Macrolides; D008387:Marine Toxins; D061065:Polyketides; C532855:amphidinolide Q; D000097442:Amphidinolides