title: Engineered nanoparticles: thrombotic events in cancer.
abstract: Engineered nanoparticles are being increasingly produced for specific applications in medicine. Broad selections of nano-sized constructs have been developed for applications in diagnosis, imaging, and drug delivery. Nanoparticles as contrast agents enable conjugation with molecular markers which are essential for designing effective diagnostic and therapeutic strategies. Such investigations can also lead to a better understanding of disease mechanisms such as cancer-associated thrombosis which remains unpredictable with serious bleeding complications and high risk of death. Here we review the recent and current applications of engineered nanoparticles in diagnosis and therapeutic strategies, noting their toxicity in relation to specific markers as a target.
authors.affiliation: Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Ahmed M E
authors.initials: AM
authors.lastname: Abdalla
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.forename: Chenxi
authors.initials: C
authors.lastname: Ouyang
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
mesh_terms: D003287:Contrast Media / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles / Q000009:adverse effects / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis*; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D003287:Contrast Media