title: Complement and IL-22: partnering up for border patrol.
abstract: Intestinal pathobionts that escape into the periphery can cause serious morbidity and death. In this issue of Immunity, Hasegawa et al. (2014) show that the host's protective measures against such events include interleukin-22-driven systemic elimination of pathobionts via complement regulation.
authors.affiliation: Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Guy's Hospital, London SE1 9RT, UK. Electronic address: claudia.kemper@kcl.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Kemper
mesh_terms: D000818:Animals; D016360:Clostridioides difficile / Q000276:immunology*; D003176:Complement C3 / Q000276:immunology*; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology*; D007378:Interleukins / Q000276:immunology*; D007422:Intestines / Q000382:microbiology*; D000097043:Interleukin-22
chemical_list: D003176:Complement C3; D007378:Interleukins; D000097043:Interleukin-22