title: The role of hyperthermic intraperitoneal chemotherapy (HIPEC) and isolated perfusion (ILP) interventions in sarcoma.
abstract: Locally advanced sarcomas in the extremity and in the retroperitoneum/abdominal cavity (peritoneal sarcomatosis, PS) can be managed administering chemotherapy locally using isolated limb perfusion (ILP) and hyperthermic intraperitoneal chemotherapy (HIPEC), respectively. In this review, the authors discuss the pros and cons of the use of these locoregional therapies in locally advanced soft tissue sarcoma, with a view to establishing their role in the multidisciplinary approach to these difficult diseases.
authors.affiliation: Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Colombo
authors.forename: Dario
authors.initials: D
authors.lastname: Baratti
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kusamura
authors.forename: Marcello
authors.initials: M
authors.lastname: Deraco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Gronchi
mesh_terms: D001132:Arm / Q000098:blood supply / Q000473:pathology; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007263:Infusions, Parenteral; D007866:Leg / Q000098:blood supply / Q000473:pathology; D012509:Sarcoma / Q000188:drug therapy / Q000628:therapy*
keywords: HIPEC; ILP; isolated limb perfusion; peritonectomy; sarcoma