title: Primary amino acid catalyzed asymmetric intramolecular Mannich reaction for the synthesis of 2-aryl-2,3-dihydro-4-quinolones.
abstract: Primary amino acids are found to be good enantioselective catalysts for the direct asymmetric Mannich reaction between 2-amino acetophenone and aldehydes. The 2-aryl-2,3-dihydro-4-quinoline products are obtained in moderate to good yields and good to high enantioselectivities with 10 mol% of the primary amino acid catalyst under mild reaction conditions.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati 781039, India. span@iitg.ernet.in.
authors.forename: Buddhadeb
authors.initials: B
authors.lastname: Mondal
authors.forename: Subhas Chandra
authors.initials: SC
authors.lastname: Pan
mesh_terms: D042462:4-Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure
chemical_list: D042462:4-Quinolones; D000596:Amino Acids