title: Role of miRNA in head and neck squamous cell carcinoma.
abstract: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Evidence suggests that miRNAs play an important role in progression, recurrence, metastasis and postoperative survival of HNSCC. Studies have investigated the utility of miRNAs as diagnostic/prognostic tools and as potential therapeutic targets and biomarkers that may improve the management and outcomes of HNSCC. The aim of this article is to review the current literature on aberrant expression profiles of miRNAs in biopsy samples of HNSCC and their role in cancer development, metastasis, prognosis and survival of these patients. This review gives an overview that miRNAs deregulation play major role in the development of HNSCC. They offer the potential to be used as biomarkers or novel therapeutic targets. Future research is required to test their use in both of these fields.
authors.affiliation: Faculty of Dentistry, Centre of Oral and Maxillofacial Diagnostics and Medicine Studies, Universiti Teknologi MARA, Level 19, Tower 2, Shah Alam, 40450, Malaysia.
authors.forename: Yaghma
authors.initials: Y
authors.lastname: Masood
authors.forename: Cheah Yoke
authors.initials: CY
authors.lastname: Kqueen
authors.forename: Pathmanathan
authors.initials: P
authors.lastname: Rajadurai
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: HNSCC; head and neck squamous cell carcinoma; metastasis; miRNA; prognosis and survival