title: Vitamin D and spondyloarthritis.
abstract: In cross-sectional studies, vitamin D deficiency is frequent in spondyloarthritic patients and associated with increased spondyloarthritis (SpA) activity and structural damage. Experimental studies also show that vitamin D interferes with molecular pathways critically involved in SpA, especially regarding entheseal inflammation and ossification (involving cytokines such as IL-23 and sclerostin). Vitamin D deficiency might also affect the course of the disease through periodontal and gut inflammation, leading to increased functional impairment. Therefore, Vitamin D receptor selective agonists could represent a promising therapeutic pathway in this pathology. Randomised-controlled intervention studies are required in order to further elucidate complex relationships between vitamin D deficiency and SpA.
authors.affiliation: Department of rheumatology, Besançon University Hospital, Boulevard Fleming, 25030, Besançon, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Guillot
authors.forename: Clément
authors.initials: C
authors.lastname: Prati
authors.forename: Daniel
authors.initials: D
authors.lastname: Wendling
mesh_terms: D000818:Animals; D006801:Humans; D025241:Spondylarthritis / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology; D014807:Vitamin D / Q000378:metabolism* / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000453:epidemiology*
chemical_list: D014807:Vitamin D
keywords: IL-23; VDR; disease activity; gut inflammation; sclerostin; spondyloarthritis; vitamin D