title: Etiopathogenic role of surfactant protein d in the clinical and immunological expression of primary Sjögren syndrome.
abstract: OBJECTIVE
  To analyze the etiopathogenic role of genetic polymorphisms and serum levels of surfactant protein-D (SP-D) in primary Sjögren syndrome (pSS).
  
  
  METHODS
  We analyzed 210 consecutive patients with pSS. SFTPD genotyping (M11T polymorphism rs721917) was analyzed by sequence-based typing and serum SP-D by ELISA.
  
  
  RESULTS
  Thirty-two patients (15%) had the Thr11/Thr11 genotype, 80 (38%) the Met11/Met11 genotype, and 96 (46%) the Met11/Thr11 genotype; 2 patients could not be genotyped. Patients carrying the Thr11/Thr11 genotype had a higher prevalence of renal involvement (13% vs 1% and 4% in comparison with patients carrying the other genotypes, p = 0.014). Serum SP-D levels were analyzed in 119 patients (mean 733.94 ± 49.88 ng/ml). No significant association was found between serum SP-D levels and the SP-D genotypes. Higher mean values of serum SP-D were observed in patients with severe scintigraphic involvement (851.10 ± 685.69 vs 636.07 ± 315.93 ng/ml, p = 0.038), interstitial pulmonary disease (1053.60 ± 852.03 vs 700.36 ± 479.33 ng/ml, p = 0.029), renal involvement (1880.64 ± 1842.79 vs 716.42 ± 488.01 ng/ml, p = 0.002), leukopenia (899.83 ± 661.71 vs 673.13 ± 465.88 ng/ml, p = 0.038), positive anti-Ro/SS-A (927.26 ± 731.29 vs 642.75 ± 377.23 ng/ml, p = 0.006), and positive anti-La/SS-B (933.28 ± 689.63 vs 650.41 ± 428.14 ng/ml, p = 0.007), while lower mean values of serum SP-D were observed in patients with bronchiectasis (489.49 vs 788.81 ng/ml, p = 0.019).
  
  
  CONCLUSIONS
  In pSS, high SP-D levels were found in patients with severe glandular involvement, hypergammaglobulinemia, leukopenia, extraglandular manifestations, and positive anti-Ro/La antibodies. The specific association between SP-D levels and pulmonary and renal involvements may have pathophysiological implications.
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: María José
authors.initials: MJ
authors.lastname: Soto-Cárdenas
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Myriam
authors.initials: M
authors.lastname: Gandía
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Pilar
authors.initials: P
authors.lastname: Brito-Zerón
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Arias
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Noelia
authors.initials: N
authors.lastname: Armiger
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Albert
authors.initials: A
authors.lastname: Bové
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bosch
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Soledad
authors.initials: S
authors.lastname: Retamozo
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Miriam
authors.initials: M
authors.lastname: Akasbi
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Marta
authors.initials: M
authors.lastname: Pérez-De-Lis
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Hoda
authors.initials: H
authors.lastname: Gueitasi
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Belchin
authors.initials: B
authors.lastname: Kostov
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pérez-Alvarez
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Antoni
authors.initials: A
authors.lastname: Siso-Almirall
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona.
authors.forename: Francisco
authors.initials: F
authors.lastname: Lozano
authors.affiliation: From the Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS); Department of Autoimmune Diseases, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología, Immunology Department, Hospital Clínic; Primary Care Research Group, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona, Barcelona; Group of Immunoreceptors, Department of Internal Medicine, Hospital Infanta Leonor, Madrid; Department of Internal Medicine, Hospital do Meixoeiro, Vigo; Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar, Cádiz, Spain.M.J. Soto-Cárdenas, MD, PhD; M. Gandía, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, and the Department of Internal Medicine, University of Cadiz, Hospital Puerta del Mar; P. Brito-Zerón, MD, PhD; A. Bové, MD, PhD; S. Retamozo, MD; H. Gueitasi, MD; M. Ramos-Casals, MD, PhD, AGAUR, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases; M.T. Arias, BSc, Immunology Department, Hospital Clínic; N. Armiger, BSc, Group of Immunoreceptors, IDIBAPS; X. Bosch, MD, PhD, Department of Internal Medicine, Instituto Clínic de Medicina y Dermatología; M. Akasbi, MD, PhD, Department of Internal Medicine, Hospital Infanta Leonor; M. Pérez-De-Lis, MD, PhD; R. Pérez-Alvarez, MD, PhD, Department of Internal Medicine, Hospital do Meixoeiro; B. Kostov, MSC; A. Siso-Almirall, MD, PhD, Primary Care Research Group, IDIBAPS, Centre d'Assistència Primària ABS Les Corts, GESCLINIC; F. Lozano, MD, PhD, Immunology Department, Hospital Clínic, Barcelona, and the Group of Immunoreceptors, IDIBAPS, and the Department of Cell Biology, Immunology and Neurosciences, School of Medicine, University of Barcelona. mramos@clinic.ub.es.
authors.forename: Manuel
authors.initials: M
authors.lastname: Ramos-Casals
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood / Q000235:genetics*; D012859:Sjogren's Syndrome / Q000097:blood / Q000235:genetics* / Q000276:immunology
chemical_list: D037663:Pulmonary Surfactant-Associated Protein D
keywords: INNATE IMMUNITY; SJÖGREN SYNDROME; SURFACTANT