title: Ultrasound/microwave-assisted solid-liquid-solid dispersive extraction with high-performance liquid chromatography coupled to tandem mass spectrometry for the determination of neonicotinoid insecticides in Dendrobium officinale.
abstract: A one-step ultrasound/microwave-assisted solid-liquid-solid dispersive extraction procedure was used for the simultaneous determination of eight neonicotinoids (dinotefuran, nitenpyram, thiamethoxam, clothianidin, imidacloprid, acetamiprid, thiacloprid, imidaclothiz) in dried Dendrobium officinale by liquid chromatography combined with electrospray ionization triple quadrupole tandem mass spectrometry in multiple reaction monitoring mode. The samples were quickly extracted by acetonitrile and cleaned up by the mixed dispersing sorbents including primary secondary amine, C18 , and carbon-GCB. Parameters that could influence the ultrasound/microwave-assisted extraction efficiency such as microwave irradiation power, ultrasound irradiation power, temperature, and solvent were investigated. Recovery studies were performing well (70.4-113.7%) at three examined spiking levels (10, 50, and 100 μg/kg). Meanwhile, the limits of quantification for the neonicotinoids ranged from 0.87 to 1.92 μg/kg. The method showed good linearity in the concentration range of 1-100 μg/L with correlation coefficients >0.99. This quick and useful analytical method could provide a basis for monitoring neonicotinoid insecticide residues in herbs.
authors.affiliation: Department of Pharmacy, Zhejiang Provincial People's Hospital, Hangzhou, China.
authors.forename: Shuilian
authors.initials: S
authors.lastname: Zheng
authors.forename: Huizhen
authors.initials: H
authors.lastname: Wu
authors.forename: Zuguang
authors.initials: Z
authors.lastname: Li
authors.forename: Jianmei
authors.initials: J
authors.lastname: Wang
authors.forename: Hu
authors.initials: H
authors.lastname: Zhang
authors.forename: Mingrong
authors.initials: M
authors.lastname: Qian
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D031667:Dendrobium / Q000737:chemistry*; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification*; D008872:Microwaves; D009574:Nitro Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D052616:Solid Phase Extraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D007306:Insecticides; D009574:Nitro Compounds
keywords: Dendrobium officinale; Microwave-assisted extraction; Neonicotinoid insecticides; Solid-liquid-solid dispersive extraction; Ultrasound-assisted extraction