title: Neurosarcoidosis.
abstract: Sarcoidosis is an idiopathic multisystem granulomatous disorder. Neurologic manifestations in sarcoidosis are varied and making a diagnosis of neurosarcoidosis can be difficult as it mimics various other neurologic diseases. Knowledge of the syndromes associated with neurosarcoidosis can help guide the diagnostic evaluation. Definitive diagnosis requires neurologic tissue evidence of noncaseating granuloma, but in practice probable diagnosis is often made through nonneurologic biopsy and a characteristic syndrome and imaging. Treatment remains empiric, but new advances in immunologic therapy hold promise for effective and less-toxic regimens.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: Shruti P
authors.initials: SP
authors.lastname: Agnihotri
authors.affiliation: Department of Neurology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Tarun
authors.initials: T
authors.lastname: Singhal
authors.affiliation: Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland.
authors.forename: Barney J
authors.initials: BJ
authors.lastname: Stern
authors.affiliation: Department of Neurology, Harvard Medical School, Boston, Massachusetts.
authors.forename: Tracey A
authors.initials: TA
authors.lastname: Cho
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001921:Brain / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D012507:Sarcoidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones