title: Non-alcoholic fatty liver disease in children: focus on nutritional interventions.
abstract: With increasing prevalence of childhood obesity, non-alcoholic fatty liver disease (NAFLD) has emerged as the most common cause of liver disease among children and adolescents in industrialized countries. It is generally recognized that both genetic and environmental risk factors contribute to the pathogenesis of NAFLD. Recently, there has been a growing body of evidence to implicate altered gut microbiota in the development of NAFLD through the gut-liver axis. The first line of prevention and treatment of NAFLD in children should be intensive lifestyle interventions such as changes in diet and physical activity. Recent advances have been focused on limitation of dietary fructose and supplementation of antioxidants, omega-3 fatty acids, and prebiotics/probiotics. Convincing evidences from both animal models and human studies have shown that reduction of dietary fructose and supplement of vitamin E, omega-3 fatty acids, and prebiotics/probiotics improve NAFLD.
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. ymlyxw@gmail.com.
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. sitangg@126.com.
authors.forename: Sitang
authors.initials: S
authors.lastname: Gong
authors.affiliation: Division of Experimental and Translational Genetics, Department of Pediatrics, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA. sqye@cmh.edu.
authors.forename: Shui Qing
authors.initials: SQ
authors.lastname: Ye
authors.affiliation: Division of Gastroenterology, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA. blyman@cmh.edu.
authors.forename: Beth
authors.initials: B
authors.lastname: Lyman
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. genglan_2001@hotmail.com.
authors.forename: Lanlan
authors.initials: L
authors.lastname: Geng
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center of Guangzhou Medical University, Guangzhou 510623, China. chenpei.y@163.com.
authors.forename: Peiyu
authors.initials: P
authors.lastname: Chen
authors.affiliation: Division of Gastroenterology, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO 64108, USA. blyman@cmh.edu.
authors.forename: Ding-You
authors.initials: DY
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage; D002648:Child; D004032:Diet; D019587:Dietary Supplements; D004195:Disease Models, Animal; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005632:Fructose / Q000008:administration & dosage; D006801:Humans; D008019:Life Style; D065626:Non-alcoholic Fatty Liver Disease / Q000517:prevention & control*; D056692:Prebiotics / Q000032:analysis; D019936:Probiotics / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D015431:Weight Loss / Q000502:physiology
chemical_list: D000975:Antioxidants; D015525:Fatty Acids, Omega-3; D056692:Prebiotics; D005632:Fructose