title: Heading forwards: anterior visceral endoderm migration in patterning the mouse embryo.
abstract: The elaboration of anterior-posterior (A-P) pattern is one of the earliest events during development and requires the precisely coordinated action of several players at the level of molecules, cells and tissues. In mammals, it is controlled by a specialized population of migratory extraembryonic epithelial cells, the anterior visceral endoderm (AVE). The AVE is a signalling centre that is responsible for several important patterning events during early development, including specifying the orientation of the A-P axis and the position of the heart with respect to the brain. AVE cells undergo a characteristic stereotypical migration which is crucial to their functions.
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Stower
authors.affiliation: Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK shankar.srinivas@dpag.ox.ac.uk.
authors.forename: Shankar
authors.initials: S
authors.lastname: Srinivas
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000196:embryology*; D004707:Endoderm / Q000166:cytology / Q000196:embryology*; D051379:Mice; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*
keywords: anterior visceral endoderm; cell migration; embryonic patterning; epithelial cell movement