title: Xenogeneic acellular dermal matrix in combination with pectoralis major myocutaneous flap reconstructs hypopharynx and cervical esophagus.
abstract: The aim of this study was to explore xenogeneic acellular dermal matrix (ADM) in combination with pectoralis major myocutaneous flap in hypopharynx and cervical esophagus reconstruction. A total of five patients were treated with this surgical method to reconstruct hypopharynx and cervical esophagus in Second Xiangya Hospital between January 2012 and April 2013. Four of them had hypopharyngeal carcinoma with laryngeal and cervical esophageal invasion, while the fifth patient with hypopharyngeal cancer had developed scars and atresia after postoperative radiotherapy. The defect length after hypopharyngeal and cervical esophageal resection was 6-8 cm, and was repaired by a combination of ADM and pectoralis major myocutaneous flap by our team. Interestingly, the four patients had primary healing and regained their eating function about 2-3 weeks after surgery, the fifth individual suffered from pharyngeal fistula, but recovered after dressing change about 2 months. Postoperative esophageal barium meals revealed that the pharynx and esophagus were unobstructed in all five patients. Xenogeneic ADM in combination with pectoralis major myocutaneous flap for hypopharynx and cervical esophagus reconstruction is a simple, safe and effective method with fewer complications. Nevertheless, according to the defect length of the cervical esophagus, the patients need to strictly follow the medical advice.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Danhui
authors.initials: D
authors.lastname: Yin
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Qinglai
authors.initials: Q
authors.lastname: Tang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Shisheng
authors.initials: S
authors.lastname: Li
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Xiangbo
authors.initials: X
authors.lastname: He
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China.
authors.forename: Mi
authors.initials: M
authors.lastname: Yang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, People's Republic of China. x16y2013@outlook.com.
authors.forename: Xinming
authors.initials: X
authors.lastname: Yang
mesh_terms: D062088:Acellular Dermis; D000328:Adult; D000818:Animals; D002417:Cattle; D004947:Esophagus / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007013:Hypopharynx / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D064827:Myocutaneous Flap; D009361:Neoplasm Invasiveness; D014183:Transplantation, Heterologous
keywords: Cervical esophagus; Hypopharyngeal carcinoma; Pectoralis major myocutaneous flap; Xenogeneic ADM