title: Rapid childhood T-ALL growth in xenograft models correlates with mature phenotype and NF-κB pathway activation but not with poor prognosis.
authors.affiliation: 1] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, Equipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, France [2] INSERM UMR967, Fontenay-aux-Roses, France [3] Université Paris Diderot, Sorbonne Paris Cité, Fontenay-aux-Roses, France [4] Université Paris-Sud, Fontenay-aux-Roses, France.
authors.forename: S
authors.initials: S
authors.lastname: Poglio
authors.affiliation: 1] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, Equipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, France [2] INSERM UMR967, Fontenay-aux-Roses, France [3] Université Paris Diderot, Sorbonne Paris Cité, Fontenay-aux-Roses, France [4] Université Paris-Sud, Fontenay-aux-Roses, France.
authors.forename: X
authors.initials: X
authors.lastname: Cahu
authors.affiliation: 1] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, Equipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, France [2] INSERM UMR967, Fontenay-aux-Roses, France [3] Université Paris Diderot, Sorbonne Paris Cité, Fontenay-aux-Roses, France [4] Université Paris-Sud, Fontenay-aux-Roses, France.
authors.forename: B
authors.initials: B
authors.lastname: Uzan
authors.affiliation: 1] CNRS UMR8104, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] INSERM U1016, Institut Cochin, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Besnard-Guérin
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital A. Trousseau et Université Pierre et Marie Curie, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Lapillonne
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital Robert Debré, Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Leblanc
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital Robert Debré, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Baruchel
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital A. Trousseau et Université Pierre et Marie Curie, Paris, France.
authors.forename: J
authors.initials: J
authors.lastname: Landman-Parker
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital A. Trousseau et Université Pierre et Marie Curie, Paris, France.
authors.forename: A
authors.identifier: 0000000183631622
authors.initials: A
authors.lastname: Petit
authors.affiliation: Institut d'Hématologie et Oncologie Pédiatrique, Hospices Civils de Lyon et Université Claude Bernard, Lyon 1, France.
authors.forename: F
authors.initials: F
authors.lastname: Baleydier
authors.affiliation: Service d'Hématologie, Institut Gustave Roussy, Villejuif, France.
authors.forename: S
authors.initials: S
authors.lastname: Amsellem
authors.affiliation: 1] CNRS UMR8104, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] INSERM U1016, Institut Cochin, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Baud
authors.affiliation: 1] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, Equipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, France [2] INSERM UMR967, Fontenay-aux-Roses, France [3] Université Paris Diderot, Sorbonne Paris Cité, Fontenay-aux-Roses, France [4] Université Paris-Sud, Fontenay-aux-Roses, France [5] Assistance Publique-Hôpitaux de Paris, Service d'hématologie pédiatrique, Hôpital A. Trousseau et Université Pierre et Marie Curie, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Ballerini
authors.affiliation: 1] Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DSV-IRCM-SCSR-LSHL, Equipe labellisée Ligue Nationale contre le Cancer, Fontenay-aux-Roses, France [2] INSERM UMR967, Fontenay-aux-Roses, France [3] Université Paris Diderot, Sorbonne Paris Cité, Fontenay-aux-Roses, France [4] Université Paris-Sud, Fontenay-aux-Roses, France.
authors.forename: F
authors.initials: F
authors.lastname: Pflumio
mesh_terms: D000293:Adolescent; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002648:Child; D018920:Coculture Techniques; D015972:Gene Expression Regulation, Neoplastic; D006085:Graft Survival; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology*; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D015398:Signal Transduction; D017154:Stromal Cells / Q000166:cytology / Q000378:metabolism; D013450:Sulfones / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D014183:Transplantation, Heterologous; D023041:Xenograft Model Antitumor Assays; D055815:Young Adult
chemical_list: C434003:3-(4-methylphenylsulfonyl)-2-propenenitrile; D000970:Antineoplastic Agents; D016328:NF-kappa B; D009570:Nitriles; D015514:Oncogene Proteins, Fusion; C547584:SIL-TAL1 fusion protein, human; D013450:Sulfones