title: Alternaria arborescens infection in a healthy individual and literature review of cutaneous alternariosis.
abstract: A 28-year-old man presented at our clinic with 1-month history of an ulcer covered with crust on his left anterior tibia. Based on the morphological features and molecular identification, the patient was diagnosed as cutaneous alternariosis caused by Alternaria arborescens. He was successfully cured by oral itraconazole and topical use of 0.25% liposomal amphotericin B. A review of published studies revealed 29 cases of cutaneous alternariosis. Most cases (90%) occurred in immunosuppressed patients; itraconazole (59%) and voriconazole (24%) are the most effective treatments of choices.
authors.affiliation: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China, huwenying31@163.com.
authors.forename: Wenying
authors.initials: W
authors.lastname: Hu
authors.forename: Yuping
authors.initials: Y
authors.lastname: Ran
authors.forename: Kaiwen
authors.initials: K
authors.lastname: Zhuang
authors.forename: Jebina
authors.initials: J
authors.lastname: Lama
authors.forename: Chaoliang
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000528:Alternaria / Q000187:drug effects / Q000302:isolation & purification; D060487:Alternariosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000188:drug therapy*; D012867:Skin / Q000382:microbiology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D017964:Itraconazole; D000666:Amphotericin B