title: [Bullous reaction after application of a single dose ingenol mebutate].
abstract: Picato (ingenol mebutate) was recently marketed for local treatment of actinic keratosis (AK). Compared to alternative creams and gels, Picato is a quick and efficient treatment, which is applied for only two to three days. A patient developed a bullous reaction to the gel after a single application. Picato 150 microg/g was applied in the evening to AK in the patient's forehead. The patient experienced a headache during the night, and the next morning big, thin-walled bullae had developed in the treated area.
authors.affiliation: Dermatologisk Afdeling, Aarhus Universitetshospital, P.P. Ørumsgade 11, 8000 Aarhus C.
authors.forename: Marie Luise
authors.initials: ML
authors.lastname: Salskov-Iversen
authors.forename: Henrik F
authors.initials: HF
authors.lastname: Lorentzen
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D004224:Diterpenes / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005546:Forehead / Q000473:pathology; D005782:Gels; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy
chemical_list: C486592:3-ingenyl angelate; D003879:Dermatologic Agents; D004224:Diterpenes; D005782:Gels