title: Formation of mixed-ligand complexes of Pd2+ with nucleoside 5'-monophosphates and some metal-ion-binding nucleoside surrogates.
abstract: Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5'-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing. The nucleoside analogs studied included 2,6-bis(3,5-dimethylpyrazol-1-yl)-, 2,6-bis(1-methylhydrazinyl)- and 6-(3,5-dimethylpyrazol-1-yl)-substituted 9-(β-d-ribofuranosyl)purines 1-3, and 2,4-bis(3,5-dimethylpyrazol-1-yl)- and 2,4-bis(1-methylhydrazinyl)-substituted 5-(β-d-ribofuranosyl)-pyrimidines 4-5. Among these, the purine derivatives 1-3 bound Pd2+ much more tightly than the pyrimidine derivatives 4, 5 despite apparently similar structures of the potential coordination sites. Compounds 1 and 2 formed markedly stable mixed-ligand Pd2+ complexes with UMP and GMP, UMP binding favored by 1 and GMP by 2. With 3, formation of mixed-ligand complexes was retarded by binding of two molecules of 3 to Pd2+.
authors.affiliation: Department of Chemistry, University of Turku, FIN-20014 Turku, Finland. oleg.golubev@utu.fi.
authors.forename: Oleg
authors.initials: O
authors.lastname: Golubev
authors.affiliation: Department of Chemistry, University of Turku, FIN-20014 Turku, Finland. tuanlo@utu.fi.
authors.forename: Tuomas
authors.initials: T
authors.lastname: Lönnberg
authors.affiliation: Department of Chemistry, University of Turku, FIN-20014 Turku, Finland. harlon@utu.fi.
authors.forename: Harri
authors.initials: H
authors.lastname: Lönnberg
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry* / Q000378:metabolism; D006157:Guanosine Monophosphate / Q000737:chemistry* / Q000378:metabolism; D008024:Ligands; D008670:Metals / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism; D010165:Palladium / Q000737:chemistry* / Q000378:metabolism; D014542:Uridine Monophosphate / Q000737:chemistry* / Q000378:metabolism
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D008670:Metals; D009705:Nucleosides; D010165:Palladium; D006157:Guanosine Monophosphate; D014542:Uridine Monophosphate