title: Pericellular proteolysis in cancer.
abstract: Pericellular proteases have long been associated with cancer invasion and metastasis due to their ability to degrade extracellular matrix components. Recent studies demonstrate that proteases also modulate tumor progression and metastasis through highly regulated and complex processes involving cleavage, processing, or shedding of cell adhesion molecules, growth factors, cytokines, and kinases. In this review, we address how cancer cells, together with their surrounding microenvironment, regulate pericellular proteolysis. We dissect the multitude of mechanisms by which pericellular proteases contribute to cancer progression and discuss how this knowledge can be integrated into therapeutic opportunities.
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Sevenich
authors.affiliation: Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, 10065, USA johanna@joycelab.org.
authors.forename: Johanna A
authors.initials: JA
authors.lastname: Joyce
mesh_terms: D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D055354:Exosomes / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology* / Q000503:physiopathology*; D010447:Peptide Hydrolases / Q000378:metabolism*; D021381:Protein Transport; D059748:Proteolysis; D059016:Tumor Microenvironment / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D010447:Peptide Hydrolases
keywords: invasion; macrophages; metastasis; migration; proteases; tumor microenvironment