title: The potential usefulness of (18)F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.
abstract: OBJECTIVE
  The aim of this study was to evaluate the potential usefulness of (18)F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.
  
  
  METHODS
  614 subjects were enrolled in this retrospective study. They underwent both (18)F-FDG PET/CT and colonoscopy in the same day as part of a cancer-screening program. Small focal FDG accumulation along the colorectum on (18)F-FDG PET/CT images were compared with colonoscopy findings. Size of lesion was measured on colonoscopy and histology was determined by biopsy or polypectomy.
  
  
  RESULTS
  In 614 (18)F-FDG PET/CT images, 27 foci of FDG uptakes were observed in the colorectal area in 25 subjects. The overall sensitivity and specificity of (18)F-FDG PET/CT were 5.6 and 96.8 %, respectively, but sensitivity to detect lesions larger than or equal to 1 cm was 25.8 %. On the ROC analysis, the optimal cut-off value for differentiating premalignant and malignant lesions from other benign conditions was 5.0 (sensitivity = 50 %, specificity = 88 %, AUC = 0.643).
  
  
  CONCLUSIONS
  Colonoscopic evaluation could be recommended by presence of focal colonic FDG uptake on (18)F-FDG PET/CT, especially when SUVmax is over 5.
authors.affiliation: Department of Radiology, Soonchunhyang University Hospital, 657, Hannam-dong, Yongsan-gu, Seoul, 140-743, South Korea.
authors.forename: Jae Pil
authors.initials: JP
authors.lastname: Hwang
authors.forename: Sang-Keun
authors.initials: SK
authors.lastname: Woo
authors.forename: Sang Yun
authors.initials: SY
authors.lastname: Yoon
authors.forename: Su Young
authors.initials: SY
authors.lastname: Jeong
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000000981:diagnostic imaging; D058070:Asymptomatic Diseases; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016099:Endoscopy, Gastrointestinal; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D012372:ROC Curve; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18