title: Development and characterization of arteether-loaded nanostructured lipid carriers for the treatment of malaria.
abstract: The purpose of the present work is to improve the antimalarial activity of the drug arteether (AE) by enhancing its solubility, by loading it into a nanostructured lipid carrier (NLC). The in vitro drug release profile of the NLC showed 93% drug release in 32 h. Complete eradication of the parasite from the blood and efficient anti-malarial pharmacological activity were observed, with the use of AE-loaded NLCs. These results suggest that nanolipid carriers of AE could be a promising carrier system to deliver the poorly soluble antimalarial drug through the oral route, by enhancing its solubility as well as preventing its degradation in the stomach.
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Zulfiqar
authors.initials: Z
authors.lastname: Ali
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mishra
authors.affiliation: a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
authors.forename: Ashish
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000627:therapeutic use; D037621:Artemisinins / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008288:Malaria / Q000188:drug therapy*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012995:Solubility
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004337:Drug Carriers; D008055:Lipids; C055141:artemotil
keywords: antimalarial activity; arteether; in vivo studies; nanolipid carrier; solubility