title: Light-triggered thiol-exchange on gold nanoparticles at low micromolar concentrations in water.
abstract: The place-exchange reaction of thiol-containing peptides in a cationic monolayer on gold nanoparticles occurs very rapidly at low micromolar concentrations in water with excellent control over the degree of substitution. The driving force for this process is the binding of anionic peptides to a cationic monolayer surface which causes a strong increase in the local concentration of thiols. The place-exchange reaction can be triggered by light using a photolabile protecting group on the thiol moiety.
authors.affiliation: Department of Chemical Sciences, University of Padova , Padova 35131, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Franceschini
authors.forename: Paolo
authors.initials: P
authors.lastname: Scrimin
authors.forename: Leonard J
authors.initials: LJ
authors.lastname: Prins
mesh_terms: D006046:Gold / Q000172:deficiency*; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D013438:Sulfhydryl Compounds; D006046:Gold