title: Daptomycin and methicillin-resistant Staphylococcus aureus isolated from a catheter-related bloodstream infection: a case report.
abstract: BACKGROUND
  Daptomycin is an alternative option for the treatment of catheter-related bloodstream-infections caused by methicillin-resistant Staphylococcus aureus. This study reports a case of a daptomycin and methicillin-resistant Staphylococcus aureus isolate recovered from the blood of a Brazilian patient undergoing hemodialysis.
  
  
  METHODS
  A 64-year-old white male patient suffering from diabetes mellitus, systolic hypertension, heart disease with a coronary stent, obesity and chronic renal failure and on use of permcath catheter developed a catheter-related bloodstream-infection by a daptomycin-methicillin-resistant Staphylococcus aureus isolate after one month of daptomycin therapy. The isolate was identified as the SCCmec II/USA100/sequence type 5 lineage by molecular techniques.
  
  
  CONCLUSIONS
  In this work we described a Brazilian patient with bloodstream infection caused by a daptomycin and methicillin-resistant Staphylococcus aureus belonging to the lineage USA100/sequence type 5. Our case highlights the careful management of bloodstream infections and the importance of the judicious use of antimicrobials due the possibility of daptomycin-resistance developing among S. aureus isolates, especially in patients under hemodialysis, which are frequently exposed to vancomycin and daptomycin therapy.
authors.forename: Fernanda S
authors.initials: FS
authors.lastname: Cavalcante
authors.forename: Dennis de C
authors.initials: Dde C
authors.lastname: Ferreira
authors.forename: Raiane C
authors.initials: RC
authors.lastname: Chamon
authors.forename: Thaina M
authors.initials: TM
authors.lastname: da Costa
authors.forename: Fernanda
authors.initials: F
authors.lastname: Maia
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Barros
authors.forename: Tatiana Silva
authors.initials: TS
authors.lastname: Dantas
authors.affiliation: Departamento de Microbiologia Médica, Laboratório de Infecção Hospitalar/UFRJ, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Av, Carlos Chagas Filho, 373, CEP: 21941-590, Rio de Janeiro, Brazil. santoskrn@micro.ufrj.br.
authors.forename: Kátia R N
authors.initials: KR
authors.lastname: Dos Santos
mesh_terms: D055499:Catheter-Related Infections / Q000097:blood* / Q000382:microbiology*; D017576:Daptomycin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D014640:Vancomycin; D017576:Daptomycin