title: Copper-catalyzed radical carbooxygenation: alkylation and alkoxylation of styrenes.
abstract: A simple copper-catalyzed direct radical carbooxygenation of styrenes is developed utilizing alkyl bromides as radical resources. This catalytic radical difunctionalization accomplishes both alkylation and alkoxylation of styrenes in one pot. A broad range of styrenes and alcohols are well tolerated in this transformation. The EPR experiment shows that alkyl halides could oxidize Cu(I) to Cu(II) in this transformation.
authors.affiliation: Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University, School of Pharmaceutical Sciences, Wuhan, 430071 (P. R. China); College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072 (P. R. China), Fax: (+86) 27-68754672.
authors.forename: Zhixiong
authors.initials: Z
authors.lastname: Liao
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Fan
authors.forename: Xu
authors.initials: X
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Zixin
authors.initials: Z
authors.lastname: Deng
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000478:Alkylation; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry*
chemical_list: D001965:Bromides; D005609:Free Radicals; D013343:Styrenes; D003300:Copper
keywords: alkoxylation; alkylation; copper catalysis; difunctionalization; radicals