title: Rhodium(III)-catalyzed three-component reaction of imines, alkynes, and aldehydes through C-H activation.
abstract: An efficient rhodium(III)-catalyzed tandem three-component reaction of imines, alkynes and aldehydes through CH activation has been developed. High stereo- and regioselectivity, as well as good yields were obtained in most cases. The simple and atom-economical approach offers a broad scope of substrates, providing polycyclic skeletons with potential biological properties.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, 610041 (P. R. China).
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Huang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Song
authors.forename: Yu-Qin
authors.initials: YQ
authors.lastname: Zhu
authors.forename: Liu
authors.initials: L
authors.lastname: Qin
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Qian
authors.forename: Lin
authors.initials: L
authors.lastname: Dong
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D007097:Imines; D011083:Polycyclic Compounds; D012238:Rhodium
keywords: CH activation; cyclization; multicomponent reactions; rhodium