title: Epithelial cell division - multiplying without losing touch.
abstract: Epithelia are compact tissues comprising juxtaposed cells that function as mechanical and chemical barriers between the body and the environment. This barrier relies, in part, on adhesive contacts within adherens junctions, which are formed and stabilized by E-cadherin and catenin proteins linked to the actomyosin cytoskeleton. During development and throughout adult life, epithelia are continuously growing or regenerating, largely as a result of cell division. Although persistence of adherens junctions is needed for epithelial integrity, these junctions are continually remodelled during cell division. In this Commentary, we will focus on cytokinesis, the final step of mitosis, a multiparty phenomenon in which the adherens junction belt plays an essential role and during which a new cell-cell interface is generated between daughter cells. This new interface is the site of intense remodelling, where new adhesive contacts are assembled and cell polarity is transmitted from mother to daughter cells, ultimately becoming the site of cell signalling.
authors.affiliation: Centre National de la Recherche Scientifique, UMR 6290, Rennes, France Université de Rennes 1, Institut de Génétique et Développement de Rennes, UEB, SFR BIOSIT, Rennes, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Le Bras
authors.affiliation: Centre National de la Recherche Scientifique, UMR 6290, Rennes, France Université de Rennes 1, Institut de Génétique et Développement de Rennes, UEB, SFR BIOSIT, Rennes, France roland.leborgne@univ-rennes1.fr.
authors.forename: Roland
authors.initials: R
authors.lastname: Le Borgne
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D002455:Cell Division; D016764:Cell Polarity; D048749:Cytokinesis; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D008938:Mitosis
keywords: Adherens junctions; Cytokinesis; Epithelial cells