title: Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.
abstract: Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation.
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. bingo525@163.com.
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. wxy@scbg.ac.cn.
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
authors.affiliation: Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China. 13694217880@163.com.
authors.forename: Jingxia
authors.initials: J
authors.lastname: Huang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. xiupinglin@hotmail.com.
authors.forename: Xiuping
authors.initials: X
authors.lastname: Lin
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. ljuan2010@qq.com.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. ljrss@126.com.
authors.forename: Shengrong
authors.initials: S
authors.lastname: Liao
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. junfeng1982a@163.com.
authors.forename: Junfeng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. xfzhou@scsio.ac.cn.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China. wls6856@163.com.
authors.forename: Lishu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China. yonghongliu@scsio.ac.cn.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002942:Circular Dichroism; D003517:Cyclopentanes / Q000737:chemistry* / Q000494:pharmacology; D016328:NF-kappa B / Q000037:antagonists & inhibitors
chemical_list: D003517:Cyclopentanes; D016328:NF-kappa B; C004511:butenolide; D015107:4-Butyrolactone; C013905:cyclopentenone