title: Antibody- and aptamer-strategies for GvHD prevention.
abstract: Prevention of Graft-versus-Host-Disease (GvHD) by preserved Graft-versus-Leukaemia (GvL) effect is one of the major obstacles following allogeneic haematopoietic stem cell transplantation. Currently used drugs are associated with side effects and were not able to separate GvHD from the GvL-effect because of general T-cell suppression. This review focuses on murine models for GvHD and currently available treatment options involving antibodies and applications for the therapeutic use of aptamers as well as strategies for targeting immune responses by allogenic antigens.
authors.affiliation: Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany.
authors.forename: Christopher
authors.initials: C
authors.lastname: Oelkrug
authors.forename: Ulrich
authors.initials: U
authors.lastname: Sack
authors.forename: Andreas
authors.initials: A
authors.lastname: Boldt
authors.forename: Isis C
authors.initials: IC
authors.lastname: Nascimento
authors.forename: Henning
authors.initials: H
authors.lastname: Ulrich
authors.forename: Stephan
authors.initials: S
authors.lastname: Fricke
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology / Q000627:therapeutic use*; D052158:Aptamers, Peptide / Q000494:pharmacology / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004195:Disease Models, Animal; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000517:prevention & control*; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology
chemical_list: D000906:Antibodies; D052158:Aptamers, Peptide
keywords: GvHD; GvL; antibody; aptamer; murine model; transplantation