title: Entosis, a key player in cancer cell competition.
abstract: Cell-in-cell structures, also referred to as 'entosis', are frequently found in human malignancies, although their prognostic impact remains to be defined. Two articles recently published in Cell Research report the stimulation of entosis by one prominent oncogene, Kras, as well as by one class of tumor suppressors, namely epithelial cadherins E and P, illustrating the complex regulation of this biological process.
authors.affiliation: 1] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, INSERM U1138, F-75006 Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, F-75005 Paris, France [3] Metabolomics and Cell Biology Platforms, Gustave Roussy, F-94805 Villejuif, France [4] Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75015 Paris, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
authors.affiliation: 1] Cell death and Aging team, Gustave Roussy, F-94805 Villejuif, France [2] Laboratory of Molecular Radiotherapy, INSERM U1030, Gustave Roussy, F-94805 Villejuif, France [3] Gustave Roussy, F-94805 Villejuif, France [4] Université Paris Sud - Paris 11, F-94805 Villejuif, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Perfettini