title: The effect of prolactin levels on MPV in women with PCOS.
abstract: OBJECTIVE
  Polycystic ovary syndrome (PCOS) is associated with cardiovascular risk factors including hypertension, obesity, hyperlipidaemia and glucose intolerance. Several studies demonstrated the link between PCOS and an increased risk of cardiovascular disease. Platelets play a crucial role in the development of atherothrombotic disease. Mean platelet volume (MPV) is a marker of platelet size that reflects its activity. Research points to a link between prolactin (PRL) and platelet activation. The purpose of this study was to investigate whether prolactin levels are associated with MPV in women with PCOS.
  
  
  METHODS
  The research was designed as a cross-sectional study.
  
  
  METHODS
  Participants were divided into three groups-PCOS patients with mildly elevated PRL levels (n = 72), patients with PCOS with normal PRL levels (n = 207) and healthy controls (n = 90). They were body mass index and age-matched and consecutively recruited.
  
  
  METHODS
  Complete blood counts, serum glucose, prolactin, insulin, lipids, high-sensitivity C-reactive protein and free-testosterone levels were measured.
  
  
  RESULTS
  Among the three groups, MPV levels were higher in women with PCOS having mildly elevated PRL levels (P < 0·001) and MPV was found to be correlated with PRL levels (r = 0·387, P < 0·001). Multiple regression analysis showed that PRL levels were associated with MPV levels (R(2) = 0·239, β = 0·354, P < 0·001).
  
  
  CONCLUSIONS
  Mean platelet volume levels are significantly increased in women with PCOS having mildly elevated PRL. Our results suggest that there is a link between prolactin and MPV levels. In women with PCOS, elevated PRL levels may increase the risk of developing atherothrombotic events via the activation of platelets.
authors.affiliation: Department of Obstetrics and Gynecology, Manisa Merkezefendi State Hospital, Inciralti, Turkey; Department of Obstetrics and Gynecology, Manisa Akhisar State Hospital, Inciralti, Turkey.
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Yilmaz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Calan
authors.forename: Tuncay
authors.initials: T
authors.lastname: Kume
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Temur
authors.forename: Pınar
authors.initials: P
authors.lastname: Yesil
authors.forename: Mehmet Y
authors.initials: MY
authors.lastname: Senses
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D063847:Mean Platelet Volume; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D012307:Risk Factors; D013739:Testosterone / Q000097:blood; D013927:Thrombosis / Q000097:blood; D055815:Young Adult
chemical_list: D007328:Insulin; D008055:Lipids; D013739:Testosterone; D011388:Prolactin; D002097:C-Reactive Protein; D005947:Glucose