title: Safety of prophylactic intracameral moxifloxacin ophthalmic solution after cataract surgery in patients with penetrating keratoplasty.
abstract: OBJECTIVE
  To determine the safety of prophylactic intracameral moxifloxacin after cataract surgery in patients with penetrating keratoplasty (PKP).
  
  
  METHODS
  In this retrospective study of consecutive patients who had phacoemulsification cataract surgery after PKP, were treated with intracameral moxifloxacin 0.5% ophthalmic solution (0.5 mg/0.1 mL). The main outcome measures were anterior chamber reaction, best corrected visual acuity (BCVA), corneal endothelial cell count (ECC), and central corneal thickness (CCT).
  
  
  RESULTS
  Fifty-five patients were recruited (26 males, 29 females). The mean age was 54.36±4.97y (range 45-64y). All eyes had improved postoperative BCVA. The mean BCVA was 0.25 preoperatively and 0.57 postoperatively, which was statistically significant (P<0.001). One eye had 3+, 7 eyes had 2+, 12 eyes had 1+ and 8 eyes had trace amount of aqueous cells on the first day after surgery. All eyes had no anterior chamber cells at subsequent follow up examinations. Effective phacoemulsification time was 4.33±1.01s. The mean ECC was 2340.20 cells/mm(2) preoperatively and 1948.75 cells/mm(2) 1mo postoperatively (P<0.001). The increase of 21.09 µm in postoperative pachymetry 1mo after surgery was statistically significant (P<0.001).
  
  
  CONCLUSIONS
  No untoward effects were observed after intracameral injection of moxifloxacin (0.5 mg/0.1 mL) in terms of anterior chamber reaction, CCT, ECC, and visual rehabilitation at the conclusion of cataract surgery in patients with PKP.
authors.affiliation: Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Osman Sevki
authors.initials: OS
authors.lastname: Arslan
authors.affiliation: Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Ceyhun
authors.initials: C
authors.lastname: Arici
authors.affiliation: Department of Ophthalmology, Medical Faculty, Akdeniz University, Antalya 07070, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Unal
authors.affiliation: Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Erdogan
authors.initials: E
authors.lastname: Cicik
authors.affiliation: Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Mehmet Serhat
authors.initials: MS
authors.lastname: Mangan
authors.affiliation: Department of Ophthalmology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul 34098, Turkey.
authors.forename: Eray
authors.initials: E
authors.lastname: Atalay
keywords: cataract surgery; intracameral injection; moxifloxacin; penetrating keratoplasty; phacoemulsification