title: An emerging antiarrhythmic target: late sodium current.
abstract: The cardiac late sodium current (INa,L) has been in the focus of research in the recent decade. The first reports on the sustained component of voltage activated sodium current date back to the seventies, but early studies interpreted this tiny current as a product of a few channels that fail to inactivate, having neither physiologic nor pathologic implications. Recently, the cardiac INa,L has emerged as a potentially major arrhythmogenic mechanism in various heart diseases, attracting the attention of clinicians and researchers. Research activity on INa,L has exponentially increased since Ranolazine, an FDA-approved antianginal drug was shown to successfully suppress cardiac arrhythmias by inhibiting INa,L. This review aims to summarize and discuss a series of papers focusing on the cardiac late sodium current and its regulation under physiological and pathological conditions. We will discuss critical evidences implicating INa,L as a potential target for treating myocardial dysfunction and cardiac arrhythmias.
authors.forename: T
authors.initials: T
authors.lastname: Banyasz
authors.forename: N
authors.initials: N
authors.lastname: Szentandrássy
authors.forename: J
authors.initials: J
authors.lastname: Magyar
authors.forename: Z
authors.initials: Z
authors.lastname: Szabo
authors.forename: P P
authors.initials: PP
authors.lastname: Nánási
authors.forename: Y
authors.initials: Y
authors.lastname: Chen-Izu
authors.affiliation: Department of Physiology, University of Debrecen, Debrecen, Hungary, H-4012 Debrecen, Nagyerdei krt. 98. PO Box 22. Banyasz.tamas@med.unideb.hu.
authors.forename: L T
authors.initials: LT
authors.lastname: Izu
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D006321:Heart / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D015222:Sodium Channels / Q000187:drug effects* / Q000502:physiology
chemical_list: D000889:Anti-Arrhythmia Agents; D015222:Sodium Channels