title: A milestone in house dust-mite-allergen immunotherapy: the new sublingual tablet S-524101 (actair).
abstract: Subcutaneous allergen-specific immunotherapy has long been used in the treatment of allergic rhinitis and/or asthma and its efficacy has been confirmed. However, due to the discomfort of injections and the risk of severe adverse reactions, alternative routes of allergen administration have emerged. Delivery of allergens through the mucosal route had been proposed and investigated thoroughly, confirming the sublingual route to be the most efficacious. Later, the efficacy and safety of this route have been documented by numerous controlled trials both for house dust mite (HDM) and pollens. Recently, sublingual orodispersable grass pollen allergen tablets were in use followed by the newly developed HDM allergen tablets with satisfactory clinical results: Moreover, very recently 1 year of HDM tablet treatment was demonstrated to exert its clinical efficacy 1 year after discontinuation of tablet IT. The persistence of efficacy after only 1 year of treatment is a new and promising era. Currently, Sublingual Immunotherapy is the most easily administered and safe treatment option until more immunogenic, less allergenic and more efficient allergen extracts are developed.
authors.affiliation: Department of Pediatrics, Division of Allergy and Clinical Immunology, Nicosia, North Cyprus, Turkey.
authors.forename: Nerin N
authors.initials: NN
authors.lastname: Bahceciler
authors.forename: Arzu
authors.initials: A
authors.lastname: Babayigit Hocaoglu
authors.forename: Nilufer
authors.initials: N
authors.lastname: Galip
mesh_terms: D000286:Administration, Sublingual; D000818:Animals; D001249:Asthma / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D039981:Pyroglyphidae / Q000276:immunology*; D013607:Tablets / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D013607:Tablets
keywords: allergic rhinitis; asthma; house dust mite; orodispersible tablets; sublingual