title: Primitive endoderm differentiation: from specification to epithelium formation.
abstract: In amniotes, primitive endoderm (PrE) plays important roles not only for nutrient support but also as an inductive tissue required for embryo patterning. PrE is an epithelial monolayer that is visible shortly before embryo implantation and is one of the first three cell lineages produced by the embryo. We review here the molecular mechanisms that have been uncovered during the past 10 years on PrE and epiblast cell lineage specification within the inner cell mass of the blastocyst and on their subsequent steps of differentiation.
authors.affiliation: Clermont Université, Université d'Auvergne, Laboratoire GReD, BP 10448, 63000 Clermont-Ferrand, France INSERM, UMR1103, 63001 Clermont-Ferrand, France CNRS, UMR6293, 63001 Clermont-Ferrand, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Hermitte
authors.affiliation: Clermont Université, Université d'Auvergne, Laboratoire GReD, BP 10448, 63000 Clermont-Ferrand, France INSERM, UMR1103, 63001 Clermont-Ferrand, France CNRS, UMR6293, 63001 Clermont-Ferrand, France claire.chazaud@udamail.fr.
authors.forename: Claire
authors.initials: C
authors.lastname: Chazaud
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000166:cytology*; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D004707:Endoderm / Q000166:cytology / Q000196:embryology*; D004848:Epithelium / Q000196:embryology*; D051519:Fibroblast Growth Factor 4 / Q000378:metabolism; D018628:Gene Dosage / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology*; D018398:Homeodomain Proteins / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D000071317:Nanog Homeobox Protein
chemical_list: C496446:Fgf4 protein, mouse; D051519:Fibroblast Growth Factor 4; D018398:Homeodomain Proteins; D000071317:Nanog Homeobox Protein; C475540:Nanog protein, mouse
keywords: blastocyst; cell differentiation; cell polarization; cell sorting; epithelium; lineage specification