title: The effect of docetaxel on developing oedema in patients with breast cancer: a systematic review.
abstract: Docetaxel is extensively used in chemotherapy for the treatment of breast cancer. Little attention has been given to oedema as a possible side effect of docetaxel-containing therapies. Until now, no review was conducted to evaluate docetaxel-containing therapies versus docetaxel-free therapies on the magnitude of the risk of developing oedema. In this systematic review, we investigated the risk of developing oedema in patients being treated for breast cancer with or without docetaxel. In this systematic literature review, we searched PubMed and Web of Knowledge for studies on breast cancer patients treated with chemotherapy containing docetaxel. We included clinical trials comparing docetaxel versus docetaxel-free chemotherapy. Oedema had to be reported and measured as a key outcome or an adverse effect. Methodological checklists were used to assess the risk of bias within the selected studies. Seven randomised clinical trials were included. Six trials were of moderate methodological quality. All trials showed an increased rate of oedema in the docetaxel-treatment arm. The trial of weakest methodological quality reported the highest incidence of oedema. The results moderately suggest that adjuvant chemotherapy containing docetaxel is related to a significantly increased risk of developing oedema, compared with docetaxel-free chemotherapy.
authors.affiliation: European College for Lymphology & Oncology, De Berekuyl/CSI-the Netherlands, Hierden, the Netherlands.|Procare Fysiotherapie & Trainingscentrum, Gorinchem, the Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Hugenholtz-Wamsteker
authors.affiliation: European College for Lymphology & Oncology, De Berekuyl/CSI-the Netherlands, Hierden, the Netherlands.|Fysiotherapie Heuts, Dinteloord, the Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Robbeson
authors.affiliation: European College for Lymphology & Oncology, De Berekuyl/CSI-the Netherlands, Hierden, the Netherlands.|Pain in Motion International Research Group (www.paininmotion.be), Brussels, Belgium.|Departments of Human Physiology & Physiotherapy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium.|Department of Physical Medicine and Physiotherapy, University Hospital Brussels, Brussels, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Nijs
authors.affiliation: European College for Lymphology & Oncology, De Berekuyl/CSI-the Netherlands, Hierden, the Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Hoelen
authors.affiliation: European College for Lymphology & Oncology, De Berekuyl/CSI-the Netherlands, Hierden, the Netherlands.|Pain in Motion International Research Group (www.paininmotion.be), Brussels, Belgium.|Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine & Health Sciences, Ghent University, Ghent, Belgium.|Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Meeus
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D004487:Edema / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000453:epidemiology*; D008408:Mastectomy; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D043823:Taxoids / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel
keywords: chemotherapy; mamma carcinoma; risk; taxotere