title: Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography.
abstract: Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility of using PS-OCT to supplement structural OCT as a possible method for intraoperative tumor margin evaluation.
authors.affiliation: Beckman Institute for Advanced Science and Technology, 405 N Mathews Avenue, Urbana, IL 61801, USA ; Department of Electrical and Computer Engineering, 306 N Wright Street, Urbana, IL 61801, USA.
authors.forename: Fredrick A
authors.initials: FA
authors.lastname: South
authors.affiliation: Beckman Institute for Advanced Science and Technology, 405 N Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Chaney
authors.affiliation: Beckman Institute for Advanced Science and Technology, 405 N Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Marjanovic
authors.affiliation: Beckman Institute for Advanced Science and Technology, 405 N Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Adie
authors.affiliation: Beckman Institute for Advanced Science and Technology, 405 N Mathews Avenue, Urbana, IL 61801, USA ; Department of Electrical and Computer Engineering, 306 N Wright Street, Urbana, IL 61801, USA ; Department of Bioengineering, 1304 W Springfield Avenue, Urbana, IL 61801, USA ; Department of Internal Medicine, 506 S Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Boppart
keywords: (110.4500) Optical coherence tomography; (110.5405) Polarimetric imaging; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (170.6935) Tissue characterization; (260.1440) Birefringence