title: A reduction and pH dual-sensitive polymeric vector for long-circulating and tumor-targeted siRNA delivery.
abstract: A novel reduction and pH dual-sensitive nonviral vector for long-circulating and tumor-targeted siRNA delivery is described. The nanomedicine is negatively charged at neutral pH of bloodstream whereas it is positively charged at lower pH of tumor tissue (ca. 6.8). Interlayer crosslinking with disulfide bonds stabilizes the nanomedicine during blood circulation and allows quick intracellular siRNA release after endocytosis.
authors.affiliation: PCFM Lab of Ministry of Education, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, China.
authors.forename: Jingguo
authors.initials: J
authors.lastname: Li
authors.forename: Xingsu
authors.initials: X
authors.lastname: Yu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.forename: Du
authors.initials: D
authors.lastname: Cheng
authors.forename: Xintao
authors.initials: X
authors.lastname: Shuai
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000737:chemistry; D045744:Cell Line, Tumor; D004705:Endocytosis; D005822:Genetic Vectors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008819:Mice, Nude; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology; D061848:Optical Imaging; D010084:Oxidation-Reduction; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared; D014162:Transfection; D014183:Transplantation, Heterologous
chemical_list: D002232:Carbocyanines; D011108:Polymers; D034741:RNA, Small Interfering; C089187:cyanine dye 3; D011092:Polyethylene Glycols
keywords: cancer treatment; charge reversal; micelles; reducible; siRNA delivery