title: Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction.
abstract: OBJECTIVE
  Although inappropriate left ventricular mass has been associated with clustered cardiac geometric and functional abnormalities, its predictive value in patients with coronary artery disease is still unknown. This study examined the association of inappropriate left ventricular mass with clinical outcomes in patients with angina pectoris and normal ejection fraction.
  
  
  METHODS
  Consecutive patients diagnosed with angina pectoris whose ejection fraction was normal were recruited from 2008 to 2012. Inappropriate left ventricular mass was determined when the ratio of actual left ventricular mass to the predicted one exceeded 150%. The primary endpoint was a composite of all-cause death, nonfatal myocardial infarction, and nonfatal stroke. Clinical outcomes between the inappropriate and appropriate left ventricular mass group were compared before and after propensity matching.
  
  
  RESULTS
  Of the total of 1515 participants, 18.3% had inappropriate left ventricular mass. Patients with inappropriate left ventricular mass had a higher composite event rate compared with those with appropriate left ventricular mass (11.2 vs. 6.6%, P=0.010). Multivariate Cox regression analyses showed that inappropriate left ventricular mass was an independent risk factor for adverse events (adjusted hazard ratio, 1.59; 95% confidence interval, 1.03-2.45; P=0.035). The worse outcome in patients with inappropriate left ventricular mass was further validated in a propensity matching cohort and patients with the traditional definition of left ventricular hypertrophy.
  
  
  CONCLUSIONS
  Inappropriate left ventricular mass was associated with an increased risk of adverse events in patients with angina pectoris and normal ejection fraction.
authors.affiliation: Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Bao-Tao
authors.initials: BT
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Peng
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Fang-Yang
authors.initials: FY
authors.lastname: Huang
authors.forename: Peng-Ju
authors.initials: PJ
authors.lastname: Wang
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Zuo
authors.forename: Yan-Biao
authors.initials: YB
authors.lastname: Liao
authors.forename: Hua
authors.initials: H
authors.lastname: Chai
authors.forename: Qiao
authors.initials: Q
authors.lastname: Li
authors.forename: Zhen-Gang
authors.initials: ZG
authors.lastname: Zhao
authors.forename: Xiao-Lin
authors.initials: XL
authors.lastname: Luo
authors.forename: Xin
authors.initials: X
authors.lastname: Ren
authors.forename: Kai-Sen
authors.initials: KS
authors.lastname: Huang
authors.forename: Qing-Tao
authors.initials: QT
authors.lastname: Meng
authors.forename: Chi
authors.initials: C
authors.lastname: Chen
authors.forename: De-Jia
authors.initials: DJ
authors.lastname: Huang
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000503:physiopathology*; D001794:Blood Pressure / Q000502:physiology; D017023:Coronary Angiography; D004562:Electrocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology*