title: From mechanism to empiricism: the evolution of heterogeneity of treatment effects.
authors.affiliation: US Outcomes Research, Center for Observational & Real-world Evidence, Merck & Co., Inc., Whitehouse Station, NJ, USA.
authors.forename: Newell E
authors.initials: NE
authors.lastname: McElwee
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Girman
mesh_terms: D066264:Datasets as Topic / Q000592:standards*; D003924:Diabetes Mellitus, Type 2 / Q000628:therapy*; D005260:Female; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000628:therapy*; D020370:Osteoarthritis, Knee / Q000628:therapy*; D010043:Outcome and Process Assessment, Health Care / Q000379:methods*; D063868:Patient Outcome Assessment
keywords: heterogeneity of treatment effect; individualization of drug therapy; personalized medicine; sub-group analysis