title: Prediction of cardiovascular risk by electrocardiographic changes in women with intrahepatic cholestasis of pregnancy.
abstract: OBJECTIVE
  We aimed to investigate P wave characteristics in pregnant women with and without intrahepatic cholestasis of pregnancy (ICP).
  
  
  METHODS
  In this case-control study, including 59 pregnant women with intrahepatic cholestasis and 28 with healthy uncomplicated pregnancies, electrocardiographic maximum (Pmax) and minimum (Pmin) P-wave durations and P-wave dispersion (Pd) parameters were investigated.
  
  
  RESULTS
  While Pmin and Pd values were significantly lower in women both with mild and severe ICP when compared to healthy pregnant women (p < 0.001), there was no significant difference between mild and severe disease groups.
  
  
  CONCLUSIONS
  Intrahepatic cholestasis predisposes to cardiovascular complications. P-wave durations and Pd constitute a recent contribution to the field of noninvasive electrocardiology. Our data clearly demonstrated that these parameters were significantly altered in pregnant women with ICP when compared to the normal ones. This important association can be used to screen for women with an increased risk to better target counseling on lifestyle modifications and to closer follow-up and management of women with a history of ICP.
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Ebru Hacer
authors.initials: EH
authors.lastname: Biberoglu
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Ayse
authors.initials: A
authors.lastname: Kirbas
authors.affiliation: b Department of Cardiology , Yuksek Ihtisas Education and Research Hospital , Ankara , Turkey , and.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Kirbas
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Cantekin
authors.initials: C
authors.lastname: Iskender
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Halil Korkut
authors.initials: HK
authors.lastname: Daglar
authors.affiliation: c Department of Cardiology , Ataturk Education and Research Hospital , Ankara , Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Koseoglu
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Dilek
authors.initials: D
authors.lastname: Uygur
authors.affiliation: a Department of Perinatology , Zekai Tahir Burak Women's Health Education and Research Hospital , Ankara , Turkey .
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology; D016022:Case-Control Studies; D002780:Cholestasis, Intrahepatic / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000209:etiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index
keywords: Cardiovascular; P wave dispersion; cholestasis; electrocardiographic screening; pregnancy