title: Atypical presentation of fever as hypersensitivity reaction to oxaliplatin.
abstract: Oxaliplatin, a third-generation, platinum-based agent is widely used, most commonly in the FOLFOX (5-fluorouracil, leucovorin and oxaliplatin) regimen, which is the first-line therapy in metastatic colorectal adenocarcinoma and adjuvant chemotherapy in stage III colorectal cancer. Platinum-based products are well known for causing hypersensitivity reactions. Fever associated with oxaliplatin-hypersensitivity reactions typically follows a specific pattern. It usually starts during the oxaliplatin infusion or immediately after (within hours instead of days) and happens after several administrations (mean 2-25) with unpredictable clinical presentations. We report a case of oxaliplatin-induced hypersensitivity reaction manifesting as fever but with unusual presentation than the aforementioned features.
authors.affiliation: Internal Medicine Residency Program, School of Medicine, University of Connecticut, Farmington, USA Khurana@resident.uchc.edu.
authors.forename: Arushi
authors.initials: A
authors.lastname: Khurana
authors.affiliation: Department of Medical Oncology, Roswell Park Cancer Institute, Buffalo, USA.
authors.forename: Demytra
authors.initials: D
authors.lastname: Mitsis
authors.affiliation: Internal Medicine Residency Program, School of Medicine, University of Connecticut, Farmington, USA.
authors.forename: Gurukripa N
authors.initials: GN
authors.lastname: Kowlgi
authors.affiliation: School of Pharmacy, University of Connecticut, Farmington, USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Holle
authors.affiliation: Neag Comprehensive Cancer Center, University of Connecticut Health Center, Farmington, USA.
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Clement
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005334:Fever / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D009944:Organoplatinum Compounds / Q000009:adverse effects*; D000077150:Oxaliplatin
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin
keywords: Oxaliplatin; fever; hypersensitivity reaction