title: Low-level prenatal lead exposure alters auditory recognition memory in 2-month-old infants: an event-related potentials (ERPs) study.
abstract: This study used event-related potentials (ERPs) to assess effects of low-level prenatal lead exposure on auditory recognition memory in 2-month-old infants. Infants were divided into four groups according to cord-blood lead concentration: (1) <2.00 μ g/dL, (2) 2.00-2.99 μ g/dL, (3) 3.0-3.7 μ g/dL, and (4) ≥3.7 μ g/dL. The first group showed the normally expected differences in P2, P750, and late slow wave (LSW) amplitudes elicited by mothers' and strangers' voices. These differences were not observed for one or more ERP components in the other groups. Thus, there was electrophysiological evidence of poorer auditory recognition memory at 2 months with cord-blood lead ≥2.00 μ g/dL.
authors.affiliation: a Center for Human Growth and Development , University of Michigan , Ann Arbor , Michigan.
authors.forename: Fengji
authors.initials: F
authors.lastname: Geng
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Mai
authors.forename: Jianying
authors.initials: J
authors.lastname: Zhan
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.forename: Jie
authors.initials: J
authors.lastname: Shao
authors.forename: John
authors.initials: J
authors.lastname: Meeker
authors.forename: Betsy
authors.initials: B
authors.lastname: Lozoff
mesh_terms: D000161:Acoustic Stimulation; D001307:Auditory Perception / Q000502:physiology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D005312:Fetal Blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D008569:Memory Disorders / Q000097:blood / Q000139:chemically induced; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood; D021641:Recognition, Psychology / Q000502:physiology*; D012959:Socioeconomic Factors; D014831:Voice
chemical_list: D007854:Lead