title: Progress in oncolytic virotherapy for the treatment of thyroid malignant neoplasm.
abstract: Thyroid malignant neoplasm develops from follicular or parafollicular thyroid cells. A higher proportion of anaplastic thyroid cancer has an adverse prognosis. New drugs are being used in clinical treatment. However, for advanced thyroid malignant neoplasm such as anaplastic thyroid carcinoma, the major impediment to successful control of the disease is the absence of effective therapies. Oncolytic virotherapy has significantly progressed as therapeutics in recent years. The advance is that oncolytic viruses can be designed with biological specificity to infect, replicate and lyse tumor cells. Significant advances in virotherapy have being achieved to improve the accessibility, safety and efficacy of the treatment. Therefore, it is necessary to summarize and bring together the main areas covered by these investigations for the virotherapy of thyroid malignant neoplasm. We provide an overview of the progress in virotherapy research and clinical trials, which employ virotherapy for thyroid malignant neoplasm as well as the future prospect for virotherapy of thyroid malignant neoplasms.
authors.affiliation: Department of Microbiology and Immunology, Temple University School of Medicine, Broad Street, 3400 N, Philadelphia, PA, USA. mingxuguan@gmail.com.|Virology, RD. Zoetis Inc, 333 Portage Street, Kalamazoo, MI, USA. mingxuguan@gmail.com.
authors.forename: Mingxu
authors.initials: M
authors.lastname: Guan
authors.affiliation: Department of Microbiology and Immunology, Temple University School of Medicine, Broad Street, 3400 N, Philadelphia, PA, USA. gromano@temple.edu.|Department of Biology, College of Science and Technology, Temple University, 12th Street, Philadelphia, PA, USA. gromano@temple.edu.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Romano
authors.affiliation: Department of Biology, College of Science and Technology, Temple University, 12th Street, Philadelphia, PA, USA. robertacoroniti@hotmail.it.
authors.forename: Roberta
authors.initials: R
authors.lastname: Coroniti
authors.affiliation: Department of Microbiology and Immunology, Temple University School of Medicine, Broad Street, 3400 N, Philadelphia, PA, USA. eehender@temple.edu.
authors.forename: Earl E
authors.initials: EE
authors.lastname: Henderson
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D050130:Oncolytic Virotherapy / Q000009:adverse effects / Q000639:trends*; D050504:Oncolytic Viruses / Q000235:genetics / Q000472:pathogenicity*; D013964:Thyroid Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D016896:Treatment Outcome