title: Decreasing prevalence of HCV coinfection in all risk groups for HIV infection between 2004 and 2011 in Spain.
abstract: While hepatitis C virus (HCV) infection seems to be expanding among HIV-infected men who have sex with men (MSM), the rate of coinfection in intravenous drug users (IDU) is assumed to remain constant. We evaluated the serial prevalence of HIV/HCV coinfection across all risk groups for HIV infection in Spain. We used data from 7045 subjects included in the multicentre, prospective Spanish Cohort of Adult HIV-infected Patients (CoRIS) between 2004 and 2011. We analysed risk factors for HIV/HCV coinfection by logistic regression analyses. The prevalence of HIV/HCV coinfection decreased from 25.3% (95% CI, 23.1-27.5) in 2004-2005 to 8.2% (95% CI, 6.9-9.5) in 2010-2011. This trend was consistently observed from 2004 to 2011 among all risk groups: IDU, 92.4% to 81.4%; MSM, 4.7% to 2.6%; heterosexual men, 13.0-8.9%; and heterosexual women, 14.5-4.0% (all P < 0.05). Strongest risk factors for HIV/HCV coinfection were IDU (OR, 54.9; 95% CI, 39.4-76.4), birth decade 1961-1970 (OR, 2.1; 95% CI, 1.1-3.7) and low educational level (OR, 2.4; 95% CI, 1.6-3.5). Hence, the prevalence of HIV/HCV coinfection decreased in Spain between 2004 and 2011. This decline was observed across all risk groups and is likely to be explained by a declining burden of HCV in the general population.
authors.affiliation: Department of Infectious Diseases, Hospital Universitario Ramón y Cajal and IRYCIS, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Serrano-Villar
authors.forename: P
authors.initials: P
authors.lastname: Sobrino-Vegas
authors.forename: S
authors.initials: S
authors.lastname: Monge
authors.forename: F
authors.initials: F
authors.lastname: Dronda
authors.forename: A
authors.initials: A
authors.lastname: Hernando
authors.forename: M
authors.initials: M
authors.lastname: Montero
authors.forename: P
authors.initials: P
authors.lastname: Viciana
authors.forename: B
authors.initials: B
authors.lastname: Clotet
authors.forename: J A
authors.initials: JA
authors.lastname: Pineda
authors.forename: J
authors.initials: J
authors.lastname: Del Amo
authors.forename: S
authors.initials: S
authors.lastname: Moreno
mesh_terms: D000328:Adult; D000818:Animals; D015331:Cohort Studies; D060085:Coinfection / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013030:Spain / Q000453:epidemiology
keywords: HCV; HIV; coinfection; injection drug use; men who have sex with men; prevalence