title: Long-term outcomes and patterns of failure in orbital lymphoma treated with primary radiotherapy.
abstract: The purpose of this study was to evaluate the long-term outcome and patterns of failure in patients treated with primary radiotherapy (RT) for orbital lymphoma (OL). Seventy-nine patients diagnosed with stage IE OL between 1995 and 2012 were included. Fifty-nine patients (75%) had mucosa-associated lymphoid tissue lymphoma and 20 patients (25%) had follicular lymphoma subtype. The median follow-up was 49.7 months. Major tumor sites were conjunctiva (29%), orbit (47%) and lacrimal gland (24%). After treatment to a median dose of 30.6 Gy, there were a total of no local, one contralateral orbital, two regional and two distant recurrences, all outside of the treatment fields. The 10-year local relapse-free, distant metastasis-free and overall survival rates were 100%, 94.2% and 98.2%, respectively. Definitive RT to 30 Gy was shown to be highly effective for indolent OL, and this study represents one of the largest single-institution studies using primary RT for stage IE OL.
authors.affiliation: Department of Radiation Oncology.
authors.forename: Rahul R
authors.initials: RR
authors.lastname: Parikh
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Moskowitz
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Maher
authors.forename: David
authors.initials: D
authors.lastname: Della Rocca
authors.forename: Robert
authors.initials: R
authors.lastname: Della Rocca
authors.forename: Bruce
authors.initials: B
authors.lastname: Culliney
authors.forename: Ilan
authors.initials: I
authors.lastname: Shapira
authors.forename: Michael L
authors.initials: ML
authors.lastname: Grossbard
authors.forename: Louis B
authors.initials: LB
authors.lastname: Harrison
authors.forename: Kenneth
authors.initials: K
authors.lastname: Hu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009918:Orbital Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D013997:Time Factors; D017211:Treatment Failure; D016896:Treatment Outcome; D055815:Young Adult
keywords: Lymphoma and Hodgkin disease; chemotherapeutic approaches; radiation