title: Hypoxic signaling during tissue repair and regenerative medicine.
abstract: In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies.
authors.affiliation: Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands. t.nauta@vumc.nl.
authors.forename: Tessa D
authors.initials: TD
authors.lastname: Nauta
authors.affiliation: Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands. v.vanhinsbergh@vumc.nl.
authors.forename: Victor W M
authors.initials: VW
authors.lastname: van Hinsbergh
authors.affiliation: Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center Amsterdam, Van der Boechorststraat 7, Amsterdam 1081 BT, The Netherlands. p.koolwijk@vumc.nl.
authors.forename: Pieter
authors.initials: P
authors.lastname: Koolwijk
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D000860:Hypoxia; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases / Q000378:metabolism; D018919:Neovascularization, Physiologic; D044968:Regenerative Medicine; D015398:Signal Transduction; D023822:Tissue Engineering; D014945:Wound Healing
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases