title: Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases.
abstract: Background and aims. Melatonin is a circulating hormone that is mainly released from the pineal gland. It possesses antioxidant, free-radical scavenging, and immune-enhancing properties. A growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabetes and periodontal diseases. The aim of this study was to examine the possible links between salivary melatonin levels and type II diabetes and periodontal diseases. Materials and methods. A total of 30 type II diabetic patients, 30 patients with periodontal diseases, 30 type II diabetic patients with periodontal disease and 30 age- and BMI-matched controls were studied. The periodontal status was evaluated by the Community Periodontal Index (CPI). Salivary melatonin levels were determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results. The mean of salivary melatonin level was significantly lower in patients with either periodontitis or diabetes compared to healthy subjects (P < 0.05). Salivary melatonin concentration decreased in type II diabetic patients and periodontitis patients, and then decreased reaching the lowest levels in type II diabetic patients with periodontal disease. Conclusion. Based on the results of this study, it can probably be concluded that salivary level of melatonin has an important role in the pathogenesis of diabetes and periodontal diseases. It is also worth noting that this factor could probably be used as a pivotal biological marker in the diagnosis and possible treatment of these diseases, although further research is required to validate this hypothesis.
authors.affiliation: Professor, Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Abdolsamadi
authors.affiliation: Professor, Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: Goodarzi
authors.affiliation: Professor, Department of Biochemistry and Nutrition, Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Ahmadi Motemayel
authors.affiliation: Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mina
authors.initials: M
authors.lastname: Jazaeri
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Javad
authors.initials: J
authors.lastname: Feradmal
authors.affiliation: Postgraduate Student, Department of Oral Medicine, Hamadan University of Medical Sciences, Haman, Iran.
authors.forename: Mahdiyeh
authors.initials: M
authors.lastname: Zarabadi
authors.affiliation: Student of Biochemistry and Nutrition, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Hoseyni
authors.affiliation: Associate Professor, Department of Periodontology, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Parviz
authors.initials: P
authors.lastname: Torkzaban
keywords: Iran; melatonin; periodontal disease; saliva; type II diabetes