title: Bifunctional submicron colloidosomes coassembled from fluorescent and superparamagnetic nanoparticles.
abstract: Colloidosomes are microcapsules consisting of nanoparticle shells. These microcarriers can be self-assembled from a wide range of colloidal particles with selective chemical, physical, and morphological properties and show promise for application in the field of theranostic nanomedicine. Previous studies have mainly focused on fairly large colloidosomes (>1 μm) based on a single kind of particle; however, the intrinsic building-block nature of this microcarrier has not been exploited so far for the introduction of tailored functionality at the nanoscale. We report a synthetic route based on interfacial shear rheology studies that allows the simultaneous incorporation of different nanoparticles with distinct physical properties, that is, superparamagnetic iron oxide and fluorescent silica nanoparticles, in a single submicron colloidosome. These tailor-made microcapsules can potentially be used in various biomedical applications, including magnetic hyperthermia, magnetic particle imaging, drug targeting, and bioimaging.
authors.affiliation: Department of Production Engineering, Advanced Ceramics, University of Bremen, Am Biologischen Garten 2, Bremen (Germany).
authors.forename: Tobias
authors.initials: T
authors.lastname: Bollhorst
authors.forename: Shakiba
authors.initials: S
authors.lastname: Shahabi
authors.forename: Katharina
authors.initials: K
authors.lastname: Wörz
authors.forename: Charlotte
authors.initials: C
authors.lastname: Petters
authors.forename: Ralf
authors.initials: R
authors.lastname: Dringen
authors.forename: Michael
authors.initials: M
authors.lastname: Maas
authors.forename: Kurosch
authors.initials: K
authors.lastname: Rezwan
mesh_terms: D003102:Colloids / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry*; D004867:Equipment Design; D005456:Fluorescent Dyes / Q000737:chemistry*; D008280:Magnetics; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D059346:Magnets / Q000737:chemistry; D008958:Models, Molecular; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods*; D010316:Particle Size; D012212:Rheology / Q000295:instrumentation / Q000379:methods*; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003102:Colloids; D003911:Dextrans; D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide; C065507:ferumoxides
keywords: colloidosomes; fluorescence; interfacial shear rheology; superparamagnetism; theranostics