title: [Evaluation of the liver functional changes due to modeling the hemodynamic effects of microgravity in bed rest studies].
abstract: Ultrasonic investigations of 8 male volunteers for bed rest at -15 degrees showed plethora in peritoneal veins and slow blood flow through the liver with no effect on biochemical parameters. Breath test with 100 mg of 13C-methacetine (MBT) pointed to diminution of the metabolic capacity and decline of the hepatic detoxification activity due to the hemodynamic effects. MBT can be used as a nonintrusive method for diagnosing functional changes in the liver induced by hemodynamic developments in microgravity and other situations triggering similar hemodynamic mechanisms.
authors.forename: B V
authors.initials: BV
authors.lastname: Afonin
authors.forename: E A
authors.initials: EA
authors.lastname: Sedova
authors.forename: G A
authors.initials: GA
authors.lastname: Tikhonova
authors.forename: A A
authors.initials: AA
authors.lastname: Solov'eva
authors.forename: V A
authors.initials: VA
authors.lastname: Valuev
mesh_terms: D000081:Acetamides; D000222:Adaptation, Physiological; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001510:Bed Rest; D001663:Bilirubin / Q000097:blood; D001783:Blood Flow Velocity / Q000502:physiology*; D001944:Breath Tests; D002247:Carbon Isotopes; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D012119:Respiration; D018474:Weightlessness Simulation; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D000081:Acetamides; D002247:Carbon Isotopes; C035495:methacetin; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin