title: Comparison of multifocal visual evoked potential, static automated perimetry, and optical coherence tomography findings for assessing visual pathways in patients with pituitary adenomas.
abstract: BACKGROUND
  There have been no studies investigating the correlation between structural [thickness of the retinal nerve fiber layer (RNFL) as determined by optical coherence tomography (OCT)] and functional [Humphrey visual field (HVF) or visual evoked potential (VEP) amplitude] measures of optic nerve integrity in patients with pituitary adenomas (PA).
  
  
  METHODS
  Patients with PAs were recruited between September 2010 and September 2013. OCT, standard automated perimetry (SAP), and multifical VEP (mfVEP) were performed. Agreement between OCT, SAP, and mfVEP values in classifying eyes/quadrants was determined using AC1 statistics. Pearson's correlation was used to examine relationships between structural and functional data.
  
  
  RESULTS
  In total, 88.7% of the eyes tested showed abnormal SAP findings and 93.7% showed abnormal mfVEP findings. Only 14.8% of the eyes showed abnormal OCT findings. The agreement between SAP and mfVEP findings was 88.9% (AC1 = 0.87). The agreement between OCT and mfVEP findings was 24.2% (AC1 = -0.52), and that between OCT and SAP findings was 21.5% (AC1 = -0.56). The correlation values between RNFL thickness and the functional measurements were -0.601 for the mfVEP score (P = 0.000) and -0.441 for the SAP score (P = 0.000). The correlation between the mfVEP and SAP scores was -0.617 (P = 0.000).
  
  
  CONCLUSIONS
  mfVEP, SAP, and OCT provided complementary information for detecting visual pathway abnormalities in patients with PAs. Good agreement was demonstrated between SAP and mfVEP and quantitative analysis of structure-function measurements revealed a moderate correlation.
authors.affiliation: Shanghai Pituitary Tumor Center, Department of Neurosurgery, HuaShan Hospital, Shanghai Medical College, Fudan University, 12# Middle Wulumuqi Road, Shanghai, 200040, China.
authors.forename: Nidan
authors.initials: N
authors.lastname: Qiao
authors.forename: Yichao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhao
authors.initials: Z
authors.lastname: Ye
authors.forename: Ming
authors.initials: M
authors.lastname: Shen
authors.forename: Xuefei
authors.initials: X
authors.lastname: Shou
authors.forename: Yongfei
authors.initials: Y
authors.lastname: Wang
authors.forename: Shiqi
authors.initials: S
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000175:diagnosis; D003430:Cross-Sectional Studies; D005074:Evoked Potentials, Visual; D006801:Humans; D015588:Observer Variation; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D014785:Vision, Ocular; D058609:Visual Field Tests; D014795:Visual Pathways / Q000473:pathology / Q000503:physiopathology