title: The relationship between coronary collateral circulation and neutrophil/lymphocyte ratio in patients with coronary chronic total occlusion.
abstract: OBJECTIVE
  To investigate the relationship between neutrophil/lymphocyte ratio (NLR) and coronary collateral circulation (CCC) in patients with coronary chronic total occlusion.
  
  
  METHODS
  Our study population consisted of 275 consecutive patients with chronic total occlusion. One hundred and thirty-eight patients with chronic total occlusion were included in the study. They were classified into 2 groups as follows: impaired CCC (group 1: Rentrop grades 0-1) and good CCC (group 2: Rentrop grades 2-3). The NLR was calculated from the complete blood count.
  
  
  RESULTS
  The NLR values of the patients with impaired CCC (4.5 ± 0.7) were significantly higher than of those with good CCC (2.7 ± 0.6, p < 0.001). In the multivariate logistic regression test, NLR (OR 33.36, 95% CI 8.189-135.7, p < 0.001), high-sensitivity C-reactive protein (hs-CRP; OR 2.152, 95% CI 1.226-3.777, p = 0.008), estimated glomerular filtration rate (OR 1.167, 95% CI 1.049-1.298, p = 0.004) and systolic blood pressure (OR 1.068, 95% CI 1.009-1.1310, p = 0.025) were independent predictors of impaired CCC. The NLR value >3.55 yielded an area under the curve value of 0.957 (95% CI 0.921-0.992, p < 0.001) and demonstrated a sensitivity of 95% and a specificity of 90% for the prediction of CCC. A moderate correlation between NLR and hs-CRP was observed (r = 0.443; p < 0.001).
  
  
  CONCLUSIONS
  Our findings reveal that NLR correlates with the impaired development of coronary collaterals.
authors.affiliation: Department of Cardiology, School of Medicine, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Alper Bugra
authors.initials: AB
authors.lastname: Nacar
authors.forename: Ali
authors.initials: A
authors.lastname: Erayman
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Eyup
authors.initials: E
authors.lastname: Buyukkaya
authors.forename: Mehmet Fatih
authors.initials: MF
authors.lastname: Karakaş
authors.forename: Adnan Burak
authors.initials: AB
authors.lastname: Akcay
authors.forename: Sule
authors.initials: S
authors.lastname: Buyukkaya
authors.forename: Nihat
authors.initials: N
authors.lastname: Sen
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D003097:Collateral Circulation / Q000276:immunology*; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000276:immunology*; D054059:Coronary Occlusion / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation / Q000097:blood; D016015:Logistic Models; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000502:physiology*; D012372:ROC Curve; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein