title: Arterial wall function is associated with cognitive performance primarily in elderly with type 2 diabetes.
abstract: Regression analyses compared 41 type 2 diabetes (T2D) and 131 non-T2D cognitively normal elderly males on the associations of arterial wall function measures [large artery elasticity index (LAEI), small artery elasticity index (SAEI), systemic vascular resistance (SVR), and total vascular impedance (TVI)] with cognitive performance (memory, language, and executive functions), controlling for socio-demographic and cardiovascular factors. Higher LAEI and lower TVI were significantly associated with better executive functions performance in T2D but not in non-T2D subjects. Lower TVI was more associated with better language performance in T2D. Results suggest that arterial wall function is associated with cognition in T2D.
authors.affiliation: Memory Clinic, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Ramit
authors.initials: R
authors.lastname: Ravona-Springer
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Stroke Unit, Neurology Department, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: Salo
authors.initials: S
authors.lastname: Haratz
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Stroke Unit, Neurology Department, Sheba Medical Center, Ramat Gan, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Tanne
authors.affiliation: Department of Psychiatry at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.affiliation: Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel The institute of Hyperbaric Medicine, Assaf Harofeh Medical Center, Zerifin, Israel Research and Development Unit, Assaf Harofeh Medical Center, Zerifin, Israel Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel.
authors.forename: Shai
authors.initials: S
authors.lastname: Efrati
authors.affiliation: James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA Department of Medicine, (Cardiology), Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Clive
authors.initials: C
authors.lastname: Rosendorff
authors.affiliation: Department of Psychiatry at the Icahn School of Medicine at Mount Sinai, New York, NY, USA Josef Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: Michal Schnaider
authors.initials: MS
authors.lastname: Beeri
authors.affiliation: Department of Psychiatry at the Icahn School of Medicine at Mount Sinai, New York, NY, USA James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA.
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
mesh_terms: D000369:Aged, 80 and over; D001794:Blood Pressure; D003071:Cognition; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000523:psychology*; D056344:Executive Function; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D009483:Neuropsychological Tests; D012044:Regression Analysis; D014655:Vascular Resistance; D014728:Veterans
keywords: Arterial wall function; cognitive function; large artery elasticity index; total vascular impedance; type 2 diabetes