title: Smart nanocarrier: self-assembly of bacteria-like vesicles with photoswitchable cilia.
abstract: Bioinspired cell deformation aids in the design of smart functional molecular self-assemblies. We report on a system of bacteria-like vesicles which release entrapped drug upon developing hairs triggered by UV irradiation, just like cilia stretching from the surface of bacteria. The formation of cilia leads to a less intact membrane, which allows release of entrapped drug. This bioinspired design created a smart nanocarrier that releases the payload via deformation rather than complete breaking.
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, People's Republic of China;
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhao
authors.forename: Yao
authors.initials: Y
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Yan
authors.forename: Jianbin
authors.initials: J
authors.lastname: Huang
mesh_terms: D000818:Animals; D001419:Bacteria; D045744:Cell Line, Tumor; D002923:Cilia / Q000528:radiation effects* / Q000648:ultrastructure; D006801:Humans; D051379:Mice; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays
keywords: azobenzene; bioinspired structure; controlled release; cyclodextrin; photoresponsive; self-assembly; vesicle