title: Mutant BRAF in low-grade epilepsy-associated tumors and focal cortical dysplasia.
abstract: BRAF alterations, namely BRAF fusion and BRAF V600E mutation, have been recently reported in low-grade epilepsy-associated tumors. Twenty low-grade epilepsy-associated tumors were retrieved to evaluate the BRAF mutational status. BRAF mutations were present in 10 tumors and concomitantly in associated dysplastic tissue of three patients. We here show for the first time that BRAF mutations are present not only in low-grade epilepsy-associated tumors but, in some cases, also in the associated focal cortical dysplasia.
authors.affiliation: Department of Biomedical and NeuroMotor Sciences (DiBiNeM), Section of Pathology "M.Malpighi", Bellaria Hospital, University of Bologna Bologna, Italy.
authors.forename: Gianluca
authors.initials: G
authors.lastname: Marucci
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Anatomic Pathology, Bellaria Hospital, University of Bologna Bologna, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: de Biase
authors.affiliation: Department of Pharmacy and Biotechnology - FaBiT, University of Bologna Bologna, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Visani
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurosurgery AUSL di Bologna, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Giulioni
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurosurgery AUSL di Bologna, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Martinoni
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurology AUSL di Bologna, Italy.
authors.forename: Llilia
authors.initials: L
authors.lastname: Volpi
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurology AUSL di Bologna, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Riguzzi
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurology AUSL di Bologna, Italy ; Danish Epilepsy Center, Epilepsihospitalet Dianalund, Denmark.
authors.forename: Guido
authors.initials: G
authors.lastname: Rubboli
authors.affiliation: IRCCS Institute of Neurological Sciences of Bologna, Division of Neurology AUSL di Bologna, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Michelucci
authors.affiliation: Department of Experimental, Diagnostic and Specialty Medicine - DIMES, Anatomic Pathology, Bellaria Hospital, University of Bologna Bologna, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tallini