title: Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-β, Smad3 and JAK-STAT pathway.
abstract: In order to find the possible mechanism of Dexamethasone (Dex) during curing fibrosis, the bleomycin (BLM)-induced mice model was used. After fibrosis were induced by BLM, histopathological evaluation and RT-PCR were employed to detect the expression of TGF-β1, Smad3 and STAT1. It was found that BLM promoted the development of inflammation, leading to severe pulmonary fibrosis with the increasing of TGF-β1, Smad3 and STAT1. After Dex treatment, the expression of TGF-β1, Smad3 and STAT1 showed a little higher with alleviation of the fibrosis. Thus it is concluded that there is a possible pathway of mouse pulmonary fibrosis model through TGF-β, Smad3 and JAK-STAT pathway.
authors.affiliation: Department of Geriatrics, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu, China.
authors.forename: Keyun
authors.initials: K
authors.lastname: Shi
authors.affiliation: Department of Geriatrics, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Jiang
authors.affiliation: Central Laboratory, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu, China.
authors.forename: Tieliang
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Geriatrics, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.affiliation: School of Medical Science and Laboratory Medicine, Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Lirong
authors.initials: L
authors.lastname: Duan
authors.affiliation: Department of Respiratory, The Affiliated Yixing Hospital of Jiangsu University Yixing, Jiangsu, China.
authors.forename: Ruhua
authors.initials: R
authors.lastname: Chen
authors.affiliation: Department of Respiratory, The Affiliated Jiangbin Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.affiliation: Department of Respiratory, The Affiliated Jiangbin Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Yu
authors.affiliation: Department of Respiratory, The Affiliated Jiangbin Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.affiliation: Department of Respiratory, The Affiliated Jiangbin Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhu
authors.affiliation: Department of Respiratory, The Affiliated Jiangbin Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
authors.forename: Jinxu
authors.initials: J
authors.lastname: Zheng
keywords: Bleomycin; JAK-STAT; Smad3; dexamethasone; idiopathic pulmonary fibrosis