title: Role of Mitochondria in Alcoholic Liver Disease.
abstract: Alcohol-induced liver disease (ALD) is a major health concern of alcohol abuse and a leading cause of liver-related morbidity and mortality. The pathogenesis of ALD is multifactorial and still ill characterized. One of the hallmarks of ALD common for both patients and experimental models is the alteration in the architecture and function of mitochondria. Due to their primordial role in energy production, metabolism and cell fate decisions, these changes in mitochondria caused by alcohol are considered an important contributory factor in ALD. A better understanding of the mechanisms underlying alcohol-mediated mitochondrial alterations may shed light on ALD pathogenesis and provide novel avenues for treatment. The purpose of the current review is to briefly update the latest developments in ALD research regarding morphological and functional mitochondrial regulation including mitochondrial dynamics and biogenesis, mitochondrial protein acetylation and evidence for an endoplasmic reticulum stress-mitochondrial cholesterol link of potential relevance for ALD.
authors.affiliation: Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), Consejo Superior Investigaciones Cientificas (CSIC) and Liver Unit-Hospital Clinic and CIBEREHD, Barcelona, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Ruiz
authors.affiliation: Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern, California, Los Angeles, CA, USA.
authors.forename: Neil
authors.initials: N
authors.lastname: Kaplowitz
authors.affiliation: Department of Cell Death and Proliferation, Institute of Biomedical Research of Barcelona (IIBB), Consejo Superior Investigaciones Cientificas (CSIC) and Liver Unit-Hospital Clinic and CIBEREHD, Barcelona, Spain. Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern, California, Los Angeles, CA, USA.
authors.forename: José C
authors.initials: JC
authors.lastname: Fernandez-Checa
keywords: ER Stress; Mitochondrial GSH; Mitochondrial biogenesis; Mitochondrial cholesterol; Mitochondrial dynamics; Mitochondrial protein acetylation