title: Stem cell treatment for Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a progressive and neurodegenerative disorder that induces dementia in older people. It was first reported in 1907 by Alois Alzheimer, who characterized the disease as causing memory loss and cognitive impairment. Pathologic characteristics of AD are β-amyloid plaques, neurofibrillary tangles and neurodegeneration. Current therapies only target the relief of symptoms using various drugs, and do not cure the disease. Recently, stem cell therapy has been shown to be a potential approach to various diseases, including neurodegenerative disorders, and in this review, we focus on stem cell therapies for AD.
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka 573-1010, Japan. liming@hirakata.kmu.ac.jp.
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Cardiac Surgery, Beijing Institute of Heart, Lung & Blood Vessel Disease, Beijing Anzhen Hospital Affiliated to Capital Medical University, Beijing 100029, China. guokequan@hotmail.com.
authors.forename: Kequan
authors.initials: K
authors.lastname: Guo
authors.affiliation: Department of Stem Cell Disorders, Kansai Medical University, 2-5-1 Shinmachi, Hirakata City, Osaka 573-1010, Japan. ikehara@hirakata.kmu.ac.jp.
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000628:therapy*; D000818:Animals; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000628:therapy*; D058225:Plaque, Amyloid / Q000378:metabolism; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*