title: Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.
abstract: The properties of benzimidazole and its derivatives have been studied over more than one hundred years. Benzimidazole derivatives are useful intermediates/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. This work systematically gives a comprehensive review in current developments of benzimidazole-based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic agents, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents. This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an SAR on benzimidazole drugs/compounds.
authors.affiliation: Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, Karnataka, 562112, India.
authors.forename: Rangappa S
authors.initials: RS
authors.lastname: Keri
authors.affiliation: Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, Karnataka, 562112, India.
authors.forename: Asha
authors.initials: A
authors.lastname: Hiremathad
authors.affiliation: Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, Karnataka, 562112, India.
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Budagumpi
authors.affiliation: Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bangalore, Karnataka, 562112, India.
authors.forename: Bhari Mallanna
authors.initials: BM
authors.lastname: Nagaraja
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000737:chemistry / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000627:therapeutic use; D001562:Benzimidazoles / Q000737:chemistry* / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D001562:Benzimidazoles; D007004:Hypoglycemic Agents; C031000:benzimidazole
keywords: anticancer; antitubercular; benzimidazole; pharmacological activity; synthesis