title: Association between primary open angle glaucoma and genetic polymorphisms GSTM1/GSTT1 in patients from Goiânia Central-West Region of Brazil.
abstract: In this study, we evaluated the genotype profile of GSTM1 and GSTT1 polymorphisms in patient carriers of primary open-angle glaucoma in the population of Goiânia, GO, Brazil. This case-control study included 100 Brazilian patients with glaucoma and 53 patients without glaucoma. Blood samples were genotyped for polymorphisms in GST genes using polymerase chain reaction-based methods. Polymorphism frequencies were compared using the X(2) test and odds ratio (α = 0.05). The GSTM1-present genotype was 40% in the glaucoma group and 71.6% in the control group, while the GSTM1 null genotype was 60 and 28.3% in the same groups, respectively. The GSTT1-present genotype was 52% in the primary open-angle glaucoma group and 66% in the control group; the null genotype was 48% in the case group and 34% in the control group. The GSTM1 null genotype was more frequent in the glaucoma group than in the control group (P = 0.0004; odds ratio = 6.7; 95% confidence interval = 2.7- 20.3). The combined GSTM1 null and GSTT1-present genotypes were more frequent in the primary open-angle glaucoma group compared to the control group (P = 0.02; odds ratio = 3.1; 95% confidence interval = 1.2-7.9).
authors.affiliation: Programa de Pós-Graduação em Genética, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: C T X
authors.initials: CT
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Genética, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: N B
authors.initials: NB
authors.lastname: Costa
authors.affiliation: Programa de Pós-Graduação em Genética, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: K S F
authors.initials: KS
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Genética, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil.
authors.forename: R E
authors.initials: RE
authors.lastname: Silva
authors.affiliation: Programa de Pós-Graduação em Genética, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brasil kkverolli@pucgoias.edu.br.
authors.forename: K K V O
authors.initials: KK
authors.lastname: Moura
mesh_terms: D000328:Adult; D000368:Aged; D001938:Brazil; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005902:Glaucoma, Open-Angle / Q000201:enzymology / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D005982:Glutathione Transferase; C413545:glutathione S-transferase T1