title: 7,8-Secolignans from the fruits of Schisandra neglecta.
abstract: Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3-6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 μM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2-5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8-28.7%. These rates are close to that of a positive control.
authors.affiliation: a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University , Kunming 650031 , China.
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Juan-Xia
authors.initials: JX
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Lou
authors.forename: Gui-You
authors.initials: GY
authors.lastname: Liu
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Gao
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D017705:Lignans; D008031:Lignin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032141:Schisandra / Q000737:chemistry*; D014027:Tobacco Mosaic Virus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D017705:Lignans; C000596419:neglectahenol E; C000596420:neglectahenol F; D008031:Lignin
keywords: 7,8-secolignans; Schisandra neglecta; anti-tobacco mosaic virus (anti-TMV) activities