title: Carotid hemodynamics is associated with monocyte count determined by serum homocysteine level in patients with essential hypertension.
abstract: To examine the association between pulsatility index (PI) in the common carotid artery (CCA) as a marker of vascular resistance and cardiovascular risk factors, including serum homocysteine and inflammation, 67 hypertensive patients were enrolled. PI correlated with homocysteine and interleukin-6, monocyte count, gender, age and BMI, with monocyte count and age being independent determinants for PI. In turn, monocyte count correlated with homocysteine, tumor necrosis factor-alpha, and HDL-cholesterol, BMI, and gender, with HDL-cholesterol and homocysteine being independent determinants for monocyte count. These results indicated monocyte count determined by homocysteine is associated with arterial stiffness in hypertensive patients.
authors.affiliation: Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine , Ehime , Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Jotoku
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okura
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Jun
authors.initials: J
authors.lastname: Irita
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nagao
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kukida
authors.forename: Akiko
authors.initials: A
authors.lastname: Tanino
authors.forename: Kayo
authors.initials: K
authors.lastname: Kudo
authors.forename: Daijiro
authors.initials: D
authors.lastname: Enomoto
authors.forename: Zouwei
authors.initials: Z
authors.lastname: Pei
authors.forename: Jitsuo
authors.initials: J
authors.lastname: Higaki
mesh_terms: D000368:Aged; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology*; D000075222:Essential Hypertension; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D018608:Ultrasonography, Doppler
chemical_list: D014409:Tumor Necrosis Factor-alpha; D006710:Homocysteine
keywords: Arterial stiffness; homocysteine; monocyte; pulsatility index