title: Flaxseed for hypertension: implications for blood pressure regulation.
abstract: Hypertension is the single largest risk factor attributed to mortality in the world. Medications are the primary treatment for hypertension; however, adherence to drug regimens is low (~50 %). Low adherence may be a contributing factor leading to uncontrolled blood pressure in patients. An effective alternative or complement to medications in managing hypertension is through lifestyle modifications. Adopting a healthy diet is a valuable strategy. A recent, randomized controlled year-long trial observed impressive reductions in blood pressure in patients with hypertension consuming flaxseed daily. Therefore, attention has been garnered for flaxseed as a potentially valuable strategy for the management of hypertension. This review will highlight the recent data for flaxseed and its extracts in blood pressure regulation in both animal models and clinical trials. Insight into the proposed anti-hypertensive mechanism of flaxseed and the implications of flaxseed as a potential global anti-hypertensive therapy will be discussed.
authors.affiliation: Canadian Centre for Agri-food Research in Health and Medicine (CCARM), St Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB, Canada, R2H 2A6.
authors.forename: Stephanie P B
authors.initials: SP
authors.lastname: Caligiuri
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Edel
authors.forename: Michel
authors.initials: M
authors.lastname: Aliani
authors.forename: Grant N
authors.initials: GN
authors.lastname: Pierce
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D019597:Flax / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008019:Life Style
chemical_list: D000959:Antihypertensive Agents