title: Nontoxigenic Vibrio cholerae non-O1/O139 isolate from a case of human gastroenteritis in the U.S. Gulf Coast.
abstract: An occurrence of Vibrio cholerae non-O1/O139 gastroenteritis in the U.S. Gulf Coast is reported here. Genomic analysis revealed that the isolate lacked known virulence factors associated with the clinical outcome of a V. cholerae infection but did contain putative genomic islands and other accessory virulence factors. Many of these factors are widespread among environmental strains of V. cholerae, suggesting that there might be additional virulence factors in non-O1/O139 V. cholerae yet to be determined. Phylogenetic analysis revealed that the isolate belonged to a phyletic lineage of environmental V. cholerae isolates associated with sporadic cases of gastroenteritis in the Western Hemisphere, suggesting a need to monitor non-O1/O139 V. cholerae in the interest of public health.
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA.
authors.forename: Nur A
authors.initials: NA
authors.lastname: Hasan
authors.affiliation: Keesler Air Force Base, Biloxi, Mississippi, USA.
authors.forename: Talayeh
authors.initials: T
authors.lastname: Rezayat
authors.affiliation: Keesler Air Force Base, Biloxi, Mississippi, USA.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blatz
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA.
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Gulf Coast Research Laboratory, The University of Southern Mississippi, Ocean Springs, Mississippi, USA.
authors.forename: Kimberly J
authors.initials: KJ
authors.lastname: Griffitt
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA.
authors.forename: Shah M
authors.initials: SM
authors.lastname: Rashed
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA Institute for Applied Environmental Health, University of Maryland, College Park, Maryland, USA.
authors.forename: Anwar
authors.initials: A
authors.lastname: Huq
authors.affiliation: Keesler Air Force Base, Biloxi, Mississippi, USA.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Conger
authors.affiliation: Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, USA University of Maryland Institute for Advanced Computer Studies, University of Maryland, College Park, Maryland, USA CosmosID, Inc., College Park, Maryland, USA Institute for Applied Environmental Health, University of Maryland, College Park, Maryland, USA Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Rita R
authors.initials: RR
authors.lastname: Colwell
authors.affiliation: Gulf Coast Research Laboratory, The University of Southern Mississippi, Ocean Springs, Mississippi, USA jay.grimes@usm.edu.
authors.forename: D Jay
authors.initials: DJ
authors.lastname: Grimes
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D016000:Cluster Analysis; D019295:Computational Biology; D005759:Gastroenteritis / Q000175:diagnosis / Q000382:microbiology*; D023061:Gene Order; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D006801:Humans; D008297:Male; D058889:Molecular Typing; D010802:Phylogeny; D014481:United States; D014735:Vibrio Infections / Q000175:diagnosis / Q000382:microbiology*; D044163:Vibrio cholerae non-O1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors