title: Hepatorenal dysfunction in sepsis: epidemiological, clinical and laboratory aspects.
abstract: The major impact of sepsis-induced multiple organ dysfunction on healthcare system in the European Union was estimated at 90.4 cases per 100000 inhabitants, compared to 58 per 100000 for breast cancer. The association of organ dysfunctions in terms of both the number of dysfunctions and the degree of organ dysfunction is the most powerful predictor of death in sepsis.
  
  
  OBJECTIVE
  To find medical and statistical correlations in hepatorenal dysfunction in sepsis patients.
  
  
  METHODS
  This retrospective study included 117 patients diagnosed with sepsis at the Iasi Infectious Diseases Hospital, patients who presented liver/renal and other organ dysfunctions. The clinical, etiological, and laboratory data, and APACHE II prognostic scores were analyzed. The data were processed using SPSS version 16.0.
  
  
  RESULTS
  The etiological agents were Gram positive as well as Gram negative bacteria, and 40% of sepsis patients with hepatic/kidney dysfunction presented hepatorenal syndrome.
  
  
  CONCLUSIONS
  Over one-third of patients with sepsis-related hepatorenal dysfunction had a creatinine clearance of less than 30 ml/min, and we found statistical correlations between serum creatinine and APACHE II score. There were no statistically significant differences between the survival curves of patients with hepatorenal syndrome and those with sepsis-related hepatorenal dysfunction.
authors.forename: Codrina
authors.initials: C
authors.lastname: Bejan
authors.forename: Simona
authors.initials: S
authors.lastname: Constantinescu
authors.forename: G
authors.initials: G
authors.lastname: Dorobăţ
authors.forename: Carmen
authors.initials: C
authors.lastname: Dorobăţ
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000652:urine; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D005062:European Union / Q000706:statistics & numerical data; D005260:Female; D006530:Hepatorenal Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology / Q000652:urine; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D003404:Creatinine