title: Comparison of total variation with a motion estimation based compressed sensing approach for self-gated cardiac cine MRI in small animal studies.
abstract: OBJECTIVE
  Compressed sensing (CS) has been widely applied to prospective cardiac cine MRI. The aim of this work is to study the benefits obtained by including motion estimation in the CS framework for small-animal retrospective cardiac cine.
  
  
  METHODS
  We propose a novel B-spline-based compressed sensing method (SPLICS) that includes motion estimation and generalizes previous spatiotemporal total variation (ST-TV) methods by taking into account motion between frames. In addition, we assess the effect of an optimum weighting between spatial and temporal sparsity to further improve results. Both methods were implemented using the efficient Split Bregman methodology and were evaluated on rat data comparing animals with myocardial infarction with controls for several acceleration factors.
  
  
  RESULTS
  ST-TV with optimum selection of the weighting sparsity parameter led to results similar to those of SPLICS; ST-TV with large relative temporal sparsity led to temporal blurring effects. However, SPLICS always properly corrected temporal blurring, independently of the weighting parameter. At acceleration factors of 15, SPLICS did not distort temporal intensity information but led to some artefacts and slight over-smoothing. At an acceleration factor of 7, images were reconstructed without significant loss of quality.
  
  
  CONCLUSIONS
  We have validated SPLICS for retrospective cardiac cine in small animal, achieving high acceleration factors. In addition, we have shown that motion modelling may not be essential for retrospective cine and that similar results can be obtained by using ST-TV provided that an optimum selection of the spatiotemporal sparsity weighting parameter is performed.
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
authors.forename: Juan F P J
authors.initials: JF
authors.lastname: Abascal
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
authors.forename: Paula
authors.initials: P
authors.lastname: Montesinos
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
authors.forename: Eugenio
authors.initials: E
authors.lastname: Marinetto
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Pascau
authors.affiliation: Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; Centro de Investigación en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
mesh_terms: D000818:Animals; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D023421:Models, Animal; D009038:Motion; D051381:Rats; D012189:Retrospective Studies