title: [Application of serum thymidine kinase 1 of 26 055 cases in health screening for early detection of premalignant/early malignant tumors].
abstract: OBJECTIVE
  To determine the application of serum thymidine kinase 1 (STK1) in general health screening for early detection of premalignant/early malignant tumors.
  
  
  METHODS
  A cross sectional study was carried out in 26 055 health screenings from 8 centers of Changsha in 2011. The concentration of STK1 was determined by a sensitive chemiluminescent dot blot ECL assay.
  
  
  RESULTS
  In the elevated STK1 group 60.35% showed diseases with a higher risk of premalignant/ early cancerous progression. The positive rate of elevated STK1 (>2.0 pmol/L) was 2.61%. There was a significantly higher rate with moderate/severe type of hyperplasia of breasts and prostate with elevated STK1 than people with normal STK1 values.
  
  
  CONCLUSIONS
  STK1 may be a reliable marker for risk assessment of premalignant/early malignant tumors.
authors.affiliation: Health Management Center, Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Pingting
authors.initials: P
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhou
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Zhiheng
authors.initials: Z
authors.lastname: Chen
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001940:Breast / Q000473:pathology; D003430:Cross-Sectional Studies; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D009369:Neoplasms / Q000175:diagnosis*; D011230:Precancerous Conditions / Q000175:diagnosis*; D011467:Prostate / Q000473:pathology; D013937:Thymidine Kinase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013937:Thymidine Kinase; C092717:thymidine kinase 1