title: Potentiometric determination of moxifloxacin in some pharmaceutical formulation using PVC membrane sensors.
abstract: BACKGROUND
  The construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.
  
  
  RESULTS
  The sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10(-2) - 4.0 × 10(-6), 1 × 10(-2) - 5.0 × 10(-6), 1 × 10(-2) - 5.0 × 10(-6) M), with detection limits of 3 × 10(-6), 4 × 10(-6) and 4.0 × 10(-6) M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.
  
  
  CONCLUSIONS
  The proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh, 11451 Saudi Arabia.
authors.forename: Mohammed M
authors.initials: MM
authors.lastname: Hefnawy
authors.affiliation: Micro-analytical Lab, National Research Center, Dokki, Cairo, Egypt.
authors.forename: Atef M
authors.initials: AM
authors.lastname: Homoda
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh, 11451 Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Abounassif
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh, 11451 Saudi Arabia.
authors.forename: Amer M
authors.initials: AM
authors.lastname: Alanazi
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh, 11451 Saudi Arabia.
authors.forename: Abdulrahaman
authors.initials: A
authors.lastname: Al-Majed
authors.affiliation: Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, P.O.Box 2457, Riyadh, 11451 Saudi Arabia.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mostafa
keywords: Moxifloxacin HCl; PVC; Phosphomolybdic acid; Phosphotungstic acid; Potentiometry; Sodium tetraphenyl borate