title: Role of nanocrystalline silver dressings in the management of toxic epidermal necrolysis (TEN) and TEN/Stevens-Johnson syndrome overlap.
abstract: Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe mucocutaneous eruptions. There is currently no defined optimal approach to wound care. The objective of this study was to evaluate silver dressings in the wound-care management of TEN and SJS/TEN syndrome overlap with a retrospective case review of nine patients with TEN and SJS/TEN overlap presenting to our institution. Nanocrystalline silver dressings appear to be useful in the rapid commencement of healing in these patients. TEN and SJS/TEN overlap are rare conditions. This contributed to a relatively small number of cases included in the study. The ease of application, antimicrobial properties and low frequency of change make nanocrystalline silver dressings ideal in TEN/SJS.
authors.affiliation: Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.|Gosford Dermatology, Gosford, New South Wales, Australia.
authors.forename: Saxon D
authors.initials: SD
authors.lastname: Smith
authors.affiliation: Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.
authors.forename: Annabel
authors.initials: A
authors.lastname: Dodds
authors.affiliation: Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.
authors.forename: Shreya
authors.initials: S
authors.lastname: Dixit
authors.affiliation: Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.|Gosford Dermatology, Gosford, New South Wales, Australia.
authors.forename: Alan
authors.initials: A
authors.lastname: Cooper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001458:Bandages; D005260:Female; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012834:Silver / Q000627:therapeutic use*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D012834:Silver
keywords: Stevens-Johnson syndrome; dressing; drug eruption; nanocrystalline silver; toxic epidermal necrolysis; wound care