title: Spectral-domain optical coherence tomography of sympathetic ophthalmia with Dalen-Fuchs nodules.
abstract: The authors present a case of sympathetic ophthalmia with Dalen-Fuchs nodules visualized with spectral-domain optical coherence tomography (SD-OCT). An 84-year-old man presented with floaters and decreased vision 25 years after penetrating trauma to the fellow eye. Examination revealed vitritis and subretinal lesions consistent with Dalen-Fuchs nodules. He was diagnosed with sympathetic ophthalmia after a negative systemic work-up. SD-OCT revealed hyper-reflective lesions at the level of the retinal pigment epithelium with disruption of the inner segment/outer segment (IS/OS) junction. Treatment resulted in clinical improvement and disappearance of Dalen-Fuchs nodules on SD-OCT; however, photoreceptor and retinal pigment epithelial disruptions persisted 5 months after treatment was initiated.
authors.forename: Nora W
authors.initials: NW
authors.lastname: Muakkassa
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Witkin
mesh_terms: D000369:Aged, 80 and over; D015807:Eye Injuries, Penetrating / Q000473:pathology; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009879:Ophthalmia, Sympathetic / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology*; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000627:therapeutic use
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide; D011241:Prednisone