title: Intramolecular redox reaction for the synthesis of N-aryl pyrroles catalyzed by Lewis acids.
abstract: An efficient approach to synthesize N-aryl pyrroles via Lewis acid-mediated 1,5-hydride shift and isomerization of 2-(3-pyrroline-1-yl)arylaldehydes has been achieved in up to 89% yield. This methodology is applicable to the synthesis of fluorazene derivatives as electron donor (D)/acceptor (A) molecules.
authors.affiliation: Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and Center of Drug Discovery, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China. hbsun2000@yahoo.com xuqing307@126.com.
authors.forename: Hong-Jin
authors.initials: HJ
authors.lastname: Du
authors.forename: Le
authors.initials: L
authors.lastname: Zhen
authors.forename: Xiaoan
authors.initials: X
authors.lastname: Wen
authors.forename: Qing-Long
authors.initials: QL
authors.lastname: Xu
authors.forename: Hongbin
authors.initials: H
authors.lastname: Sun
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry; D007536:Isomerism; D058116:Lewis Acids / Q000737:chemistry*; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D006575:Heterocyclic Compounds, 3-Ring; D058116:Lewis Acids; D011758:Pyrroles; C548493:fluorazene; C013231:pyrroline