title: MCP-1 and CCR2 gene polymorphisms in Parkinson's disease in a Han Chinese cohort.
abstract: Monocyte chemoattractant protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR2) play important roles in neuroinflammation and they have been shown to be involved in Parkinson's disease (PD) pathogenesis. In addition, several studies have suggested a role for the MCP-1 and CCR2 genotypes in cognitive impairment and depression, which are common non-motor symptoms in PD patients. In this study, a cohort of 521 PD patients and 556 cases of healthy controls were recruited to investigate the association between the MCP-1 2518A/G (rs1064211) and CCR2 V64I (rs1799864) gene polymorphisms and PD risk in the Chinese population. We also analyze the influence of these genotypes on the cognitive function and depression in PD patients by comparing Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Wechsler Adult Intelligence Scale-Chinese Revision (WAIS-RC), Wechsler Memory Scale-Chinese Revision (WMS-RC) and Hamilton Depression Rating Scale (HAMD) ratings in 217 PD patients. Our results showed no significant differences in the genotype frequency between the PD group and the control group (P > 0.05). In addition, we also failed to find an influence of the MCP-1 and CCR2 genotypes on MMSE scores, MoCA scores, WAIS-RC scores, WMS-RC scores and HAMD scores in PD patients (P > 0.05). The MCP-1 and CCR2 gene polymorphisms may not be genetic risk factors for PD in the Han Chinese population, and they do not appear to influence cognitive function and depression in PD patients.
authors.affiliation: Department of Neurology, Guangdong Neuroscience Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Rd II, Guangzhou, 510080, Guangdong Province, People's Republic of China, gaoliang0123@sina.com.
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Hongmei
authors.initials: H
authors.lastname: Tang
authors.forename: Kun
authors.initials: K
authors.lastname: Nie
authors.forename: Limin
authors.initials: L
authors.lastname: Wang
authors.forename: Jiehao
authors.initials: J
authors.lastname: Zhao
authors.forename: Rong
authors.initials: R
authors.lastname: Gan
authors.forename: Jing
authors.initials: J
authors.lastname: Huang
authors.forename: Shujun
authors.initials: S
authors.lastname: Feng
authors.forename: Ruiming
authors.initials: R
authors.lastname: Zhu
authors.forename: Zhenpeng
authors.initials: Z
authors.lastname: Duan
authors.forename: Youwen
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuhu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Wang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D018932:Chemokine CCL2 / Q000235:genetics*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D054390:Receptors, CCR2 / Q000235:genetics*
chemical_list: C111835:CCL2 protein, human; C515334:CCR2 protein, human; D018932:Chemokine CCL2; D054390:Receptors, CCR2