title: DNA repair mechanisms and human cytomegalovirus (HCMV) infection.
abstract: Herpesvirus infections, such as those induced by human cytomegalovirus (HCMV), induce specific DNA damages. DNA damages can lead to cell mutation, death, apoptosis and immune system activation. Various types of DNA damage are repaired through multiple repair pathways, such as base excision, nucleotide excision, homologous recombination and nonhomologous end joining. Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection.
authors.affiliation: Department of Fetal-Maternal Medicine and Gynaecology, Polish Mother's Memorial Hospital Research Institute, 281/289 Rzgowska Street, Lodz, 93-338, Poland, smolbea@wp.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Smolarz
authors.forename: Jan
authors.initials: J
authors.lastname: Wilczyński
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowakowska
mesh_terms: D000818:Animals; D003587:Cytomegalovirus / Q000502:physiology*; D003586:Cytomegalovirus Infections / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism / Q000382:microbiology; D004249:DNA Damage; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism; D006801:Humans
chemical_list: D045643:DNA Repair Enzymes