title: [Varenicline poisoning for a suicidal purpose].
abstract: Varenicline is a partial agonist on cerebral nicotine receptors and is indicated for smoking cessation. There are only a few case reports of intended overdose of varenicline. We report a history of a 45-year-old woman who ingested 40-50 mg varenicline. She spontaneously vomited shortly after ingestion which may be due to varenicline's effect on gastrointestinal 5-hydroxytryptamine3-receptors. At admission to hospital she received activated charcoal. ECG-monitoring and blood samples were all normal. She was discharged the following day.
authors.affiliation: Klinisk Farmakologisk Afdeling, -Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV. fsoe0011@regionh.dk.
authors.forename: Freja Hemmingsen
authors.initials: FH
authors.lastname: Sørup
authors.forename: Anders Bay
authors.initials: AB
authors.lastname: Neumann
authors.forename: Helle
authors.initials: H
authors.lastname: Holst
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D018722:Nicotinic Agonists / Q000494:pharmacology / Q000506:poisoning*; D013406:Suicide, Attempted; D000068580:Varenicline / Q000494:pharmacology / Q000506:poisoning*; D014839:Vomiting
chemical_list: D000931:Antidotes; D018722:Nicotinic Agonists; D002606:Charcoal; D000068580:Varenicline