title: HIV and HCV coinfection: prevalence, associated factors and genotype characterization in the Midwest Region of Brazil.
abstract: A cross-sectional study on prevalence, associated factors and genotype distribution of HCV infection was conducted among 848 HIV-infected patients recruited at reference centers in the Midwest Region of Brazil. The prevalence rate of HIV-HCV coinfection was 6.9% (95% CI: 5.2 to 8.6). In multivariable analysis, increasing age, use of illicit drugs (injection and non-injection), a history of blood transfusion before 1994, and the absence of a steady partnership were significant independent associated factors for HIV-HCV coinfection. The phylogenetic analysis based on the NS5B region revealed the presence of two major circulating genotypes of HCV: genotypes 1 (58.3%) and 3 (41.7%). The prevalence of HIV-HCV coinfection was lower than those reported in studies conducted with HIV-infected patients in different regions of Brazil, due to the fact that illicit drug use is not a frequent mode of HIV transmission in this region of Brazil. Serologic screening of HIV-patients for HCV before initiating antiretroviral treatment, a comprehensive identification of associated factors, and the implementation of effective harm reduction programs are highly recommended to provide useful information for treatment and to prevent HCV coinfection in these patients.
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Solange Zacalusni
authors.initials: SZ
authors.lastname: Freitas
authors.affiliation: Federal University of Goiás, Goiânia, GO, Brazil.
authors.forename: Sheila Araújo
authors.initials: SA
authors.lastname: Teles
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Paulo Cesar
authors.initials: PC
authors.lastname: Lorenzo
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Marco Antonio Moreira
authors.initials: MA
authors.lastname: Puga
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Tayana Serpa Ortiz
authors.initials: TS
authors.lastname: Tanaka
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Danilo Yamamoto
authors.initials: DY
authors.lastname: Thomaz
authors.affiliation: Federal University of Goiás, Goiânia, GO, Brazil.
authors.forename: Regina Maria Bringel
authors.initials: RM
authors.lastname: Martins
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Angelita Fernandes
authors.initials: AF
authors.lastname: Druzian
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Andréa Siqueira Campos
authors.initials: AS
authors.lastname: Lindenberg
authors.affiliation: Hematology and Hemotherapy Center of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Marina Sawada
authors.initials: MS
authors.lastname: Torres
authors.affiliation: Laboratory of Viral Hepatitis, Rio de Janeiro, RJ, Brazil.
authors.forename: Sérgio A
authors.initials: SA
authors.lastname: Pereira
authors.affiliation: Laboratory of Viral Hepatitis, Rio de Janeiro, RJ, Brazil.
authors.forename: Livia Melo
authors.initials: LM
authors.lastname: Villar
authors.affiliation: Laboratory of Viral Hepatitis, Rio de Janeiro, RJ, Brazil.
authors.forename: Elisabete
authors.initials: E
authors.lastname: Lampe
authors.affiliation: Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Ana Rita Coimbra
authors.initials: AR
authors.lastname: Motta-Castro
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D060085:Coinfection / Q000453:epidemiology / Q000821:virology; D003430:Cross-Sectional Studies; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000453:epidemiology*; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010802:Phylogeny; D015995:Prevalence; D012367:RNA, Viral / Q000235:genetics*; D012307:Risk Factors
chemical_list: D012367:RNA, Viral