title: Highly efficient antibacterial iron oxide@carbon nanochains from wüstite precursor nanoparticles.
abstract: A new hydrothermal synthesis approach involving the carbonization of glucose in the presence of wüstite (FeO) nanoparticles is presented, which leads to the fabrication of rapidly acting and potent antibacterial agents based on iron oxide@carbon (IO@C) nanochains. By using nonmagnetic FeO precursor nanoparticles that slowly oxidize into the magnetic Fe3O4 crystal structure under hydrothermal conditions, we were able to prepare well-defined and short-length IO@C nanochains that are highly dispersed in aqueous media and readily interact with bacterial cells, leading to a complete loss in bacterial cell viability within short incubation times at minimal dosage. The smaller IO@C nanochains synthesized using the FeO precursor nanoparticles can reach above 2-fold enhancement in microbe-killing activity when compared to the larger nanochains fabricated directly from Fe3O4 nanoparticles. In addition, the synthesized IO@C nanochains can be easily isolated using an external magnet and be subsequently recycled to effectively eradicate Escherichia coli cells even after five separate treatment cycles.
authors.affiliation: Department of Chemistry, Case Western Reserve University , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
authors.forename: Shu F
authors.initials: SF
authors.lastname: Situ
authors.forename: Anna Cristina S
authors.initials: AC
authors.lastname: Samia
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry; D005296:Ferrous Compounds / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry; D008280:Magnetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D050296:Microbial Viability / Q000187:drug effects; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005296:Ferrous Compounds; D017382:Reactive Oxygen Species; D002244:Carbon; C034236:ferrous oxide; D005947:Glucose; D052203:Ferrosoferric Oxide
keywords: carbon-based nanomaterials; hydrothermal carbonization; iron oxide nanoparticles; magnetic hybrid nanostructures; recyclable antibacterial agents