title: Role of inflammation in diabetic macular edema.
abstract: Vitreous fluid levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)-2, soluble intercellular adhesion molecule (sICAM)-1, monocyte chemotactic protein (MCP)-1 and pentraxin 3 (PTX3) were measured by enzyme-linked immunosorbent assay in 36 patients with diabetic macular edema (DME) and 15 patients with macular hole (MH). Aqueous flare values were measured with a laser flare meter, and macular edema was examined by optical coherence tomography. Vitreous fluid levels of VEGF, sVEGFR-2, sICAM-1, MCP-1 and PTX3 were significantly higher in the patients with DME than in those with MH. There was a significant correlation between the vitreous fluid level of sVEGFR-2 and the levels of sICAM-1, MCP-1 and PTX3. The aqueous flare value was significantly correlated with the vitreous fluid levels of sVEGFR-2, sICAM-1, MCP-1 and PTX3. These findings suggest that inflammatory factors may induce an increase in vascular permeability and disrupt the blood-aqueous barrier in DME patients.
authors.affiliation: Department of Ophthalmology, Hachioji Medical Center, Tokyo Medical University, Hachioji, Tokyo, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.forename: Kanako
authors.initials: K
authors.lastname: Yasuda
authors.forename: Masahiko
authors.initials: M
authors.lastname: Shimura
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D001813:Blood-Retinal Barrier / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism; D002199:Capillary Permeability / Q000502:physiology; D018932:Chemokine CCL2 / Q000378:metabolism; D003930:Diabetic Retinopathy / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008269:Macular Edema / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012167:Retinal Perforations / Q000378:metabolism; D000683:Serum Amyloid P-Component / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018932:Chemokine CCL2; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1; D000683:Serum Amyloid P-Component; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2; D000099153:Pentraxins; C111835:CCL2 protein, human; C573420:ICAM1 protein, human; C467484:VEGFA protein, human