title: [Inflammatory myopathy with initial respiratory muscles involvement and rheumatoid arthritis].
abstract: Inflammatory myopathies comprise a heterogeneous group of subacute, chronic and sometimes acute acquired muscle diseases. The most common inflammatory myopathies seen in practice can be separated into four distinct subsets: polymyositis, dermatomyositis, necrotizing autoimmune myositis and inclusion body myositis. These disorders present as proximal and symmetric muscle weakness but rarely respiratory muscles may also be affected. We report the case of a 39 year-old female with inflammatory myopathy with acute respiratory failure due to alveolar hypoventilation secondary to respiratory muscle dysfunction that required mechanical ventilation. The treatment with steroids, methotrexate and intravenous immune globulin was successful as well as the implementation of non-invasive ventilation as an alternative to endotracheal intubation.
authors.affiliation: Servicio de Clínica Médica, Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina. E-mail: huntmart@gmail.com.
authors.forename: Martín
authors.initials: M
authors.lastname: Hunter
authors.forename: Irene
authors.initials: I
authors.lastname: Telias
authors.forename: Victoria
authors.initials: V
authors.lastname: Collado
authors.forename: Judith
authors.initials: J
authors.lastname: Sarano
authors.forename: Clarisa
authors.initials: C
authors.lastname: Alvarez
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Suárez
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D001706:Biopsy; D057645:Deltoid Muscle / Q000473:pathology; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D009220:Myositis / Q000188:drug therapy / Q000276:immunology*; D063087:Noninvasive Ventilation; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy; D012132:Respiratory Muscles / Q000473:pathology*
chemical_list: D018501:Antirheumatic Agents; D016756:Immunoglobulins, Intravenous
keywords: immunosuppression; myositis; noninvasive ventilation; respiratory insufficiency