title: Diabetic kidney disease; review of the current knowledge.
abstract: Diabetes is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) in most parts of the world. 20 to 30% of diabetic patient have diabetic nephropathy in type 1 and type 2. Hyperglycemia is the key of nephropathy creation. Hyperglycemia also by production of toxic materials, advanced glycosylated end product (AGE), increased activity of aldose reductase has some role. Some metabolites of arachidonic acid, hemodynamic derangements and genetic factors have also some role. Although diabetic nephropathy is most common cause of nephropathy in these patients, but diabetic patients are also prone to other urinary tract and renal parenchymal disease and should not be confused with renal failure due to diabetic nephropathy. The principle of treatment of diabetic nephropathy is based on tight control of hyperglycemia, tight control of blood pressure and glomerular pressure, control of dyslipidemia, restriction of protein intake and smoking withdrawal.
authors.affiliation: Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Heshmatollah
authors.initials: H
authors.lastname: Shahbazian
authors.affiliation: Department of Nephrology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Isa
authors.initials: I
authors.lastname: Rezaii
keywords: Chronic kidney disease; Diabetic kidney disease; End-stage renal disease