title: 18F-FDOPA PET for the diagnosis of parkinsonian syndromes.
abstract: 18F-FDOPA PET has been historically used for the evaluation of parkinsonian syndromes in research settings. With the wider availability of PET cameras and 18F-DOPA this method can be used as a clinical diagnostic tool. Current acquisition protocols are simple with a 10 minute static acquisition performed 90 minutes post injection. Criteria for precise visual analysis of the images are defined. The performances of the method are reviewed throughout the literature. The method is very sensitive for detection of IPD versus normal patients. Few studies comparing 18F-FDOPA PET and DAT SPECT did not show any difference in diagnostic accuracy. 18F-FDOPA PET is reliable for evaluation of IPD progression. In general, atypical Parkinson's syndromes cannot be reliably differentiated from IPD since they share a similar nigro-striatal degeneration process. However, some patterns such as the asymmetrical faint homogeneous striatal uptake reduction pattern of CBD can be recognized. The short acquisition protocol, the various indications in oncology of 18F-FDOPA and the high quality of PET images are in favor of this technique in daily clinical practice for the improvement of diagnosis of parkinsonian syndromes.
authors.affiliation: Nuclear Medicine, University of Nice, Nice, France - darcourt@unice.fr.
authors.forename: J
authors.initials: J
authors.lastname: Darcourt
authors.forename: A
authors.initials: A
authors.lastname: Schiazza
authors.forename: N
authors.initials: N
authors.lastname: Sapin
authors.forename: M
authors.initials: M
authors.lastname: Dufour
authors.forename: M J
authors.initials: MJ
authors.lastname: Ouvrier
authors.forename: D
authors.initials: D
authors.lastname: Benisvy
authors.forename: X
authors.initials: X
authors.lastname: Fontana
authors.forename: P M
authors.initials: PM
authors.lastname: Koulibaly
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D018450:Disease Progression; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020734:Parkinsonian Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine