title: IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection.
abstract: In the present study, the aim was to reveal the relationship of serum IL-6, IL-10 and IL-13 levels in patient with Enterovirus 71 (EV71) infection. To elucidate the role of immune mechanisms in the pathogenesis of Hand, foot, and mouth disease (HFMD), we analyzed the cytokine of 112 EV71-infected patients. A significant elevation of serum (interleukin) IL-6, IL-10 and IL-13 levels in patients with EV71 infection compare with Un-EV71 infection HFMD patient and Healthy individuals. The production of inflammatory cytokines was increased with disease clinical stage. In addition, the immunological consequences of these cytokine in patient with EV71 infection showed a downward trend after cure. These data suggested that EV71 infection significantly increased the release of circulating IL-6, IL-10 and IL-13. The systemic inflammatory response may play an important role in the pathogenesis of HFMD. Moreover, this study may be designed to evaluate the potential therapeutic of medicine in the treatment of patients with EV71 infection.
authors.affiliation: Department of Pediatrics, Dongguan People's Hospital Dongguan 523059, China.
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Pediatrics, Dongguan People's Hospital Dongguan 523059, China.
authors.forename: Ruiqin
authors.initials: R
authors.lastname: Li
authors.affiliation: Department of Pediatrics, Dongguan People's Hospital Dongguan 523059, China.
authors.forename: Zhichao
authors.initials: Z
authors.lastname: Xie
authors.affiliation: Department of Pediatrics, Dongguan People's Hospital Dongguan 523059, China.
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Huang
authors.affiliation: Department of Pediatrics, Dongguan People's Hospital Dongguan 523059, China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Yuan
authors.affiliation: Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guandong Medical College Dongguan 523808, China.
authors.forename: Jincheng
authors.initials: J
authors.lastname: Zeng
keywords: Enterovirus 71; Hand food mouth disease (HFMD); neurologic pulmonary edema; pro-inflammatory