title: [Danish Cholinesterase Research Unit diagnoses patients with prolonged paralysis after succinylcholine and mivacurium].
abstract: The Danish Cholinesterase Research Unit (DCRU) is a nationwide unit for patients carrying mutations in the butyrylcholinesterase enzyme (BChE). BChE hydrolyzes the neuromuscular blocking drugs succinylcholine and mivacurium. Patients with mutations in the butyrylcholinesterase gene are at risk of experiencing a prolonged effect of the drugs, such as weakness or paralysis for hours. In order to diagnose the referred patients correctly, DCRU combines results such as BChE activity, genotyping, pedigree and clinical reactions to succinylcholine or mivacurium.
authors.affiliation: Anæstesiologisk Afdeling I, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev. k-eskildsen@hotmail.com.
authors.forename: Katrine Zwicky
authors.initials: KZ
authors.lastname: Eskildsen
authors.forename: Mona Ring
authors.initials: MR
authors.lastname: Gätke
mesh_terms: D002091:Butyrylcholinesterase / Q000235:genetics*; D003718:Denmark; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects* / Q000494:pharmacology; D000077590:Mivacurium; D009154:Mutation; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects* / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000494:pharmacology; D010243:Paralysis / Q000139:chemically induced*; D013390:Succinylcholine / Q000009:adverse effects* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D007546:Isoquinolines; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002091:Butyrylcholinesterase; D013390:Succinylcholine