title: Carbapenemase-producing Klebsiella pneumoniae.
abstract: The continuing emergence of infections due to multidrug resistant bacteria is a serious public health problem. Klebsiella pneumoniae, which commonly acquires resistance encoded on mobile genetic elements, including ones that encode carbapenemases, is a prime example. K. pneumoniae carrying such genetic material, including both blaKPC and genes encoding metallo-β-lactamases, have spread globally. Many carbapenemase-producing K. pneumoniae are resistant to multiple antibiotic classes beyond β-lactams, including tetracyclines, aminoglycosides, and fluoroquinolones. The optimal treatment, if any, for infections due to these organisms is unclear but, paradoxically, appears to often require the inclusion of an optimally administered carbapenem.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine 300 Pasteur Drive, Stanford, CA 94305 USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Robilotti
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine 300 Pasteur Drive, Stanford, CA 94305 USA.
authors.forename: Stan
authors.initials: S
authors.lastname: Deresinski