title: Atypical Antidepressant Activity of 3,4-Bis(3,4-Dimethoxyphenyl) Furan-2,5-Dione Isolated from Heart Wood of Cedrus deodara, in Rodents.
abstract: Cedrus deodara (Pinaceae) has been used traditionally in Ayurveda for the treatment of central nervous system disorders. 3,4-bis(3,4-dimethoxyphenyl)furan-2,5-dione (BDFD) was isolated from heart wood of Cedrus deodara and was shown to have antiepileptic and anxiolytic activity. Thus, the present study was aimed to explore its anti-depressant effect and to correlate the effect with serotonin and nor adrenaline levels of brain. Albino mice were used as experimental animal. Animals were divided in to three groups; vehicle control, imipramine (30 mg/kg i.p.), BDFD (100 mg/kg i.p.). Tail suspension test (TST) and forced swim test (FST) was performed to evaluate antidepressant effect of BDFD. BDFD (100 mg/kg, i.p.) showed a significant decrease in immobility time when subjected to FST whereas immobility time was not significantly altered in TST. BDFD treatment increased serotonin and noradrenaline levels in the brain which is indicative of BDFD having possible atypical antidepressant action.
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Nitesh
authors.initials: N
authors.lastname: Kumar
authors.affiliation: Farooqia College of Pharmacy, Mysore 570021, Karnataka, India.
authors.forename: Daniel
authors.initials: D
authors.lastname: Dhayabaran
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Madhavan
authors.initials: M
authors.lastname: Nampoothiri
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Krishnadas
authors.initials: K
authors.lastname: Nandakumar
authors.affiliation: Department of Pharmaceutical Technology, Anna University Chennai, Regional Office, Tiruchirappalli 620 024, Tamil Nadu, India.
authors.forename: A
authors.initials: A
authors.lastname: Puratchikody
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Natasha
authors.initials: N
authors.lastname: Lalani
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Karima
authors.initials: K
authors.lastname: Dawood
authors.affiliation: Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India.
authors.forename: Aanesha
authors.initials: A
authors.lastname: Ghosh
keywords: Anti-depressant; Cedrus; Noradrenaline; Serotonin