title: Recurrent BRCA1 and BRCA2 mutations in Mexican women with breast cancer.
abstract: BACKGROUND
  Germline mutations in the BRCA1 and BRCA2 genes confer an estimated 58% to 80% lifetime risk of breast cancer. In general, screening is done for cancer patients if a relative has been diagnosed with breast or ovarian cancer. There are few data on the prevalence of mutations in these genes in Mexican women with breast cancer and this hampers efforts to develop screening policies in Mexico.
  
  
  METHODS
  We screened 810 unselected women with breast cancer from three cities in Mexico (Mexico City, Veracruz, and Monterrey) for mutations in BRCA1 and BRCA2, including a panel of 26 previously reported mutations.
  
  
  RESULTS
  Thirty-five mutations were identified in 34 women (4.3% of total) including 20 BRCA1 mutations and 15 BRCA2 mutations. Twenty-two of the 35 mutations were recurrent mutations (62.8%). Only five of the 34 mutation carriers had a first-degree relative with breast cancer (three with BRCA1 and two with BRCA2 mutations).
  
  
  CONCLUSIONS
  These results support the rationale for a strategy of screening for recurrent mutations in all women with breast cancer in Mexico, as opposed to restricting screening to those with a sister or mother with breast or ovarian cancer.
  
  
  CONCLUSIONS
  These results will impact cancer genetic testing in Mexico and the identification of at-risk individuals who will benefit from increased surveillance. Cancer Epidemiol Biomarkers Prev; 24(3); 498-505. ©2014 AACR.
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, México.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Torres-Mejía
authors.affiliation: Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Royer
authors.affiliation: Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Marcia
authors.initials: M
authors.lastname: Llacuachaqui
authors.affiliation: Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mohammad R
authors.initials: MR
authors.lastname: Akbari
authors.affiliation: Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida. Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa, Florida.
authors.forename: Anna R
authors.initials: AR
authors.lastname: Giuliano
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, México.
authors.forename: Louis
authors.initials: L
authors.lastname: Martínez-Matsushita
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, México.
authors.forename: Angélica
authors.initials: A
authors.lastname: Angeles-Llerenas
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, México.
authors.forename: Carolina
authors.initials: C
authors.lastname: Ortega-Olvera
authors.affiliation: Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics; Helen Diller Family Comprehensive Cancer Center; Department of Epidemiology and Biostatistics, University of California, San Francisco, California.
authors.forename: Elad
authors.initials: E
authors.lastname: Ziv
authors.affiliation: Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, México.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Lazcano-Ponce
authors.affiliation: Department of Cancer Epidemiology, Population Sciences Division, Moffitt Cancer Center, Tampa, Florida. Catherine.phelan@moffitt.org.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Phelan
authors.affiliation: Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged