title: Percutaneous vertebroplasty in vertebral metastases from breast cancer: interest in terms of pain relief and quality of life.
abstract: Percutaneous vertebroplasty (PV) is a therapeutic option in patients with vertebral metastases (VM). However its efficacy in pain relief, improvement in quality of life and safety in patients with VM from breast cancer has not been reported. We present a longitudinal retrospective study of 31 consecutively treated female patients with VM from breast cancer where 88 vertebrae were treated in 44 sessions of PV, in which osteolytic, osteoblastic and mixed lesions were recorded. The visual analogue pain scale (VAS) was used to evaluate pain pre-PV, at one, three, six and 12 months post-PV. The Eastern Cooperative Group (ECOG) performance status scale was used at the same time intervals to measure quality of life: 90.3% pain relief was identified with a VAS reduction from 5.7 ± 2.0 pre-PV to 2.9 ± 2.2 post-PV at one-month follow-up (p<0.001) and 0.6 ± 1.0 at 12-month follow-up (p<0.001). In our series 48.4% of patients were classified as having an ECOG grade 0 and 1 pre-PV, which increased to 80.8% at the 12-month follow-up. While 22.6% of the patients were classified at ECOG grades 3 and 4 pre-PV, this improved to 0% at 12 months follow-up. The morbidity rate for this procedure was 12.9% immediately and only 3.2% at 30 days post-PV with all complications being resolved medically or with CT-guided infiltration. PV is a safe procedure with a high efficacy in pain relief, and improvement of quality of life in patients with diverse types of VM from breast cancer.
authors.affiliation: Magnetic Resonance Unit, Institute of Neurobiology, UNAM-Campus Juriquilla; Querétaro, México - hectorbarragan@yahoo.com.
authors.forename: Héctor Manuel
authors.initials: HM
authors.lastname: Barragán-Campos
authors.affiliation: Research Unit 4069, MGEN Public Health Foundation, René Descartes University; Paris, France.
authors.forename: Anne-Laurence
authors.initials: AL
authors.lastname: Le Faou
authors.affiliation: Department of Anesthesiology, Pitié-Salpêtrière Hospital; Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Rose
authors.affiliation: Institute Curie Medical Information Service; Paris, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Livartowski
authors.affiliation: Institute Curie Medical Information Service; Paris, France.
authors.forename: Marianne
authors.initials: M
authors.lastname: Doz
authors.affiliation: Department of Public Health Pitié-Salpêtrière, Pitié-Salpêtrière Hospital; Paris, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Astagneau
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, Pitié-Salpêtrière Hospital; Paris, France.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Cormier
authors.affiliation: Department of Diagnostic and Interventional Neuroradiology, Pitié-Salpêtrière Hospital; Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Chiras
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000523:psychology; D059408:Pain Management / Q000379:methods*; D010147:Pain Measurement; D011183:Postoperative Complications / Q000453:epidemiology / Q000628:therapy; D011788:Quality of Life; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D054854:Vertebroplasty / Q000009:adverse effects / Q000379:methods*
keywords: breast cancer; pain relief; percutaneous vertebroplasty; quality of life; vertebral metastases