title: Progress in developing analytical and label-based dietary supplement databases at the NIH Office of Dietary Supplements.
abstract: Although an estimated 50% of adults in the United States consume dietary supplements, analytically substantiated data on their bioactive constituents are sparse. Several programs funded by the Office of Dietary Supplements (ODS) at the National Institutes of Health enhance dietary supplement database development and help to better describe the quantitative and qualitative contributions of dietary supplements to total dietary intakes. ODS, in collaboration with the United States Department of Agriculture, is developing a Dietary Supplement Ingredient Database (DSID) verified by chemical analysis. The products chosen initially for analytical verification are adult multivitamin-mineral supplements (MVMs). These products are widely used, analytical methods are available for determining key constituents, and a certified reference material is in development. Also MVMs have no standard scientific, regulatory, or marketplace definitions and have widely varying compositions, characteristics, and bioavailability. Furthermore, the extent to which actual amounts of vitamins and minerals in a product deviate from label values is not known. Ultimately, DSID will prove useful to professionals in permitting more accurate estimation of the contribution of dietary supplements to total dietary intakes of nutrients and better evaluation of the role of dietary supplements in promoting health and well-being. ODS is also collaborating with the National Center for Health Statistics to enhance the National Health and Nutrition Examination Survey dietary supplement label database. The newest ODS effort explores the feasibility and practicality of developing a database of all dietary supplement labels marketed in the US. This article describes these and supporting projects.
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Johanna T
authors.initials: JT
authors.lastname: Dwyer
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: Picciano
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Betz
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Kenneth D
authors.initials: KD
authors.lastname: Fisher
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Leila G
authors.initials: LG
authors.lastname: Saldanha
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Yetley
authors.affiliation: Office of Dietary Supplements, National Institutes of Health, US Department of Health and Human Services (DHHS), Bethesda, MD, USA.
authors.forename: Paul M
authors.initials: PM
authors.lastname: Coates
authors.affiliation: Nutritional Sciences Research Group, National Cancer Institute, US DHHS, Bethesda, MD, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Milner
authors.affiliation: Nutritional Sciences Research Group, National Cancer Institute, US DHHS, Bethesda, MD, USA.
authors.forename: Jackie
authors.initials: J
authors.lastname: Whitted
authors.affiliation: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control and Prevention, US DHHS, Hyattsville, MD, USA.
authors.forename: Vicki
authors.initials: V
authors.lastname: Burt
authors.affiliation: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control and Prevention, US DHHS, Hyattsville, MD, USA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Radimer
authors.affiliation: National Health and Nutrition Examination Survey, National Center for Health Statistics, Centers for Disease Control and Prevention, US DHHS, Hyattsville, MD, USA.
authors.forename: Jaimie
authors.initials: J
authors.lastname: Wilger
authors.affiliation: National Institute of Standards and Technology, Gaithersburg, MD, USA.
authors.forename: Katherine E
authors.initials: KE
authors.lastname: Sharpless
authors.affiliation: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA.
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Holden
authors.affiliation: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA.
authors.forename: Karen
authors.initials: K
authors.lastname: Andrews
authors.affiliation: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA.
authors.forename: Janet
authors.initials: J
authors.lastname: Roseland
authors.affiliation: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA.
authors.forename: Cuiwei
authors.initials: C
authors.lastname: Zhao
authors.affiliation: Nutrient Data Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service (ARS), US Department of Agriculture (USDA), Beltsville, MD, USA.
authors.forename: Amy
authors.initials: A
authors.lastname: Schweitzer
authors.affiliation: Food Composition Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, Beltsville, MD, USA.
authors.forename: James
authors.initials: J
authors.lastname: Harnly
authors.affiliation: Food Composition Laboratory, Beltsville Human Nutrition Research Center, ARS, USDA, Beltsville, MD, USA.
authors.forename: Wayne R
authors.initials: WR
authors.lastname: Wolf
authors.affiliation: Research and Development Division, National Agricultural Statistics Service, USDA, Fairfax, VA, USA.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Perry
keywords: Analytical substantiation; Certified reference materials; DSID; DSLD-USA; Dietary supplement composition; Dietary supplement ingredient database; Dietary supplement labels; Dietary supplements; NHANES; NHANES-DSLD; Standard reference materials®