title: Preliminary observations on high energy phosphates and metabolic pathway and transporter potentials in extensor carpi radialis brevis and trapezius muscles of women with work-related myalgia.
abstract: This study compared both the extensor carpi radialis brevis (ECRB) and the trapezius (TRAP) muscles of women with work-related myalgia (WRM) with healthy controls (CON) to determine whether abnormalities existed in cellular energy status and the potentials of the various metabolic pathways and segments involved in energy production and substrate transport. For both the ECRB (CON, n = 6-9; WRM, n = 13) and the TRAP (CON, n = 6-7; WRM, n = 10), no differences (P > 0.05) were found for the concentrations (in millimoles per kilogram of dry mass) of ATP, PCr, lactate, and glycogen. Similarly, with one exception, the maximal activities (in moles per milligram of protein per hour) of mitochondrial enzymes representative of the citric acid cycle (CAC), the electron transport chain (ETC), and β-oxidation, as well as the cytosolic enzymes involved in high energy phosphate transfer, glycogenolysis, glycolysis, lactate oxidation, and glucose phosphorylation were not different (P > 0.05). The glucose transporters GLUT1 and GLUT4, and the monocarboxylate transporters MCT1 and MCT4, were also normal in WRM. It is concluded that, in general, abnormalities in the resting energy and substrate state, the potential of the different metabolic pathways and segments, as well as the glucose and monocarboxylate transporters do not appear to be involved in the cellular pathophysiology of WRM.
authors.affiliation: a Department of Kinesiology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Green
authors.forename: Don
authors.initials: D
authors.lastname: Ranney
authors.forename: Margaret
authors.initials: M
authors.lastname: Burnett
authors.forename: Patti
authors.initials: P
authors.lastname: Galvin
authors.forename: Natasha
authors.initials: N
authors.lastname: Kyle
authors.forename: David
authors.initials: D
authors.lastname: Lounsbury
authors.forename: Jing
authors.initials: J
authors.lastname: Ouyang
authors.forename: Ian C
authors.initials: IC
authors.lastname: Smith
authors.forename: Riley
authors.initials: R
authors.lastname: Stewart
authors.forename: Heather
authors.initials: H
authors.lastname: Tick
authors.forename: A Russell
authors.initials: AR
authors.lastname: Tupling
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053858:Metabolic Networks and Pathways; D008875:Middle Aged; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism*; D063806:Myalgia / Q000378:metabolism*; D009784:Occupational Diseases / Q000378:metabolism*; D010755:Organophosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D064171:Superficial Back Muscles / Q000378:metabolism; D027981:Symporters / Q000378:metabolism*; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D000255:Adenosine Triphosphate; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; D010755:Organophosphates; D010725:Phosphocreatine; D027981:Symporters; D000099233:Monocarboxylate Transport Protein 1; C406962:SLC16A4 protein, human
keywords: energy potential; glucose transporters; microtraumatismes répétés; monocarboxylate transporters; muscle squelettique; potentiel d’énergie; repetitive strain injury; skeletal muscle; transporteurs de glucose; transporteurs de monocarboxylate