title: Mouse model of subarachnoid hemorrhage: technical note on the filament perforation model.
abstract: Experiments using genetically engineered mice are regarded as indispensable to gaining a better understanding of the molecular pathophysiology in neuronal injury after subarachnoid hemorrhage (SAH). Therefore, mouse SAH models are becoming increasingly important. The circle of Willis perforation (cWp) model is the most frequently used mouse SAH model. We report and discuss the technical surgical approach, results, and difficulties associated with the cWp model, with reference to the existing literature. Our results largely confirmed previously published results. This model may be the first choice at present, because important pathologies can be reproduced in this model and most findings in the literature are based on it.
authors.affiliation: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan, carl.muroi@ksa.ch.
authors.forename: Carl
authors.initials: C
authors.lastname: Muroi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Fujioka
authors.forename: Serge
authors.initials: S
authors.lastname: Marbacher
authors.forename: Javier
authors.initials: J
authors.lastname: Fandino
authors.forename: Emanuela
authors.initials: E
authors.lastname: Keller
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005818:Genetic Engineering / Q000379:methods; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D019635:Neurosurgical Procedures / Q000379:methods; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D020301:Vasospasm, Intracranial / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery