title: Primary gastrointestinal stromal tumors: Current advances in diagnostic biomarkers, prognostic factors and management of its duodenal location.
abstract: Gastrointestinal stromal tumors (GIST) constitute 1-3% of all gastrointestinal malignancies and is the most common mesenchymal tumor of the gastrointestinal tract. Although GIST were first described in the literature in the year 1941, important advances of kit mutation and tyrosine kinase inhibitors were not made to understand and manage GIST until the last decade. Here current advances in research of possible cellular origin, diagnostic biomarkers and prognostic factors of primary GIST are reviewed, and the management of primary duodenal GIST is focused on due to its specific location. It is possible that personalized assessment and therapy will turn out to be another milestone for primary GIST.
authors.affiliation: Department of Hepatobiliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;
authors.forename: Yuesi
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Hepatobiliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;
authors.forename: Meihai
authors.initials: M
authors.lastname: Deng
authors.affiliation: Department of General Surgery, Lingnan Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Hepatobiliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.affiliation: Department of Hepatobiliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;
authors.forename: Mingliang
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Hepatobiliary Surgery, Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China;
authors.forename: Ruiyun
authors.initials: R
authors.lastname: Xu
keywords: Gastrointestinal stromal tumor; diagnostic biomarker; primary duodenal GIST; prognostic factor