title: Tumor-infiltrating lymphocytes in breast cancer: A new predictor for responses to therapy.
abstract: We have prospectively validated in an independent clinical cohort the finding that elevated amounts of tumor-infiltrating lymphocytes in breast carcinoma tissues predict the response of patients to neoadjuvant chemotherapy. These results suggest that a robust tumor infiltration by T and B cells is a promising biomarker to define patients who might benefit from neoadjuvant chemotherapy.
authors.affiliation: German Breast Group; Neu-Isenburg, Germany.
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Issa-Nummer
authors.affiliation: German Breast Group; Neu-Isenburg, Germany.
authors.forename: Sibylle
authors.initials: S
authors.lastname: Loibl
authors.affiliation: German Breast Group; Neu-Isenburg, Germany.
authors.forename: Gunter
authors.initials: G
authors.lastname: von Minckwitz
authors.affiliation: Institute of Pathology; Charité-Universitätsmedizin Berlin; Berlin, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Denkert
keywords: biological marker; breast cancer; neoadjuvant chemotherapy; response predictor