title: Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis.
abstract: Antimicrobial drug discovery has slowed considerably over the last few decades. One major cause for concern is the lack of innovative approaches to treat infections caused by mycobacteria such as TB. Herein we demonstrate that our Small Molecule Variable Ligand Display (SMLVD) method for nanoparticle antibiotic discovery can be expanded around a ligand feed ratio parameter space to identify gold nanoparticle conjugates that are potent inhibitors of mycobacteria growth, with our most potent inhibitor able to reduce growth by five orders of magnitude at 8 μM.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA. daniel.feldheim@colorado.edu.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Gifford
authors.forename: Jamee
authors.initials: J
authors.lastname: Bresee
authors.forename: Carly Jo
authors.initials: CJ
authors.lastname: Carter
authors.forename: Guankui
authors.initials: G
authors.lastname: Wang
authors.forename: Roberta J
authors.initials: RJ
authors.lastname: Melander
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Feldheim
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects; D006046:Gold / Q000737:chemistry*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D013438:Sulfhydryl Compounds; D006046:Gold