title: Interleukin-7 and interleukin-15 for cancer.
abstract: Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Paul
authors.initials: P
authors.lastname: Zarogoulidis
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Sofia
authors.initials: S
authors.lastname: Lampaki
authors.affiliation: 2. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, U.S.A.
authors.forename: Lonny
authors.initials: L
authors.lastname: Yarmus
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kioumis
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Georgia
authors.initials: G
authors.lastname: Pitsiou
authors.affiliation: 3. Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Katsikogiannis
authors.affiliation: 4. II Medical Clinic, ``Coburg`` Hospital, University of Wuerzburg, Coburg, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hohenforst-Schmidt
authors.affiliation: 5. Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: 5. Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, China.
authors.forename: Haidong
authors.initials: H
authors.lastname: Huang
authors.affiliation: 6. Pathology Department, ``G. Papanikolaou`` General Hospital, Thessaloniki, Greece.
authors.forename: Antonios
authors.initials: A
authors.lastname: Sakkas
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Organtzis
authors.affiliation: 6. Pathology Department, ``G. Papanikolaou`` General Hospital, Thessaloniki, Greece.
authors.forename: Leonidas
authors.initials: L
authors.lastname: Sakkas
authors.affiliation: 7. Oncology Department, ``BioMedicine`` Private Hospital, Thessaloniki, Greece.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mpoukovinas
authors.affiliation: 8. Cardiothoracic Surgery Department, ``Saint Luke`` Private Hospital, Thessaloniki, Greece.
authors.forename: Kosmas
authors.initials: K
authors.lastname: Tsakiridis
authors.affiliation: 9. Oncology Department, ``G. Papageorgiou`` University Hospital, Thessaloniki, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Lazaridis
authors.affiliation: 10. Oncology Department, ``Sotiria`` Hospital, University of Athens, Athens, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Syrigos
authors.affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Zarogoulidis
keywords: Cancer; IL-15; IL-7; Imunomodulation.