title: ROS-cleavable proline oligomer crosslinking of polycaprolactone for pro-angiogenic host response.
abstract: A reactive oxygen species (ROS)-degradable scaffold is fabricated by crosslinking biocompatible, hydrolytically-degradable poly(ε-caprolactone) (PCL) with a ROS-degradable oligoproline peptide, KP7K. The ROS-mediated degradability triggers favorable host responses of the scaffold including improved cell infiltration and angiogenesisin vivo, indicating its unique advantages for tissue engineering applications.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Sue Hyun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Boire
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Jung Bok
authors.initials: JB
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Mukesh K
authors.initials: MK
authors.lastname: Gupta
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Zachman
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Rutwik
authors.initials: R
authors.lastname: Rath
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, Nashville TN 37235, USA. Tel: +1-6153226986.
authors.forename: Hak-Joon
authors.initials: HJ
authors.lastname: Sung