title: Novel features of early burst suppression predict outcome after birth asphyxia.
abstract: Burst suppression patterns in the electroencephalogram are a reliable marker of recent severe brain insult. Here we analyze statistical properties of bursts occurring in 20 electroencephalographic recordings acquired from hypothermic asphyxic newborns in the hours immediately following birth. We show that the distributions of burst area and duration in these acute data predict later clinical outcome in both structural neuroimaging and neurodevelopment. Our findings indicate the first early electroencephalographic metrics that offer outcome prediction in asphyxic neonates undergoing hypothermia treatment.
authors.affiliation: Systems Neuroscience Group, QIMR Berghofer Medical Research Institute Brisbane, Queensland, Australia ; School of Medicine, Faculty of Medicine and Biomedical Sciences, University of Queensland Queensland, Australia.
authors.forename: Kartik K
authors.initials: KK
authors.lastname: Iyer
authors.affiliation: Systems Neuroscience Group, QIMR Berghofer Medical Research Institute Brisbane, Queensland, Australia.
authors.forename: James A
authors.initials: JA
authors.lastname: Roberts
authors.affiliation: Children's Hospital, Helsinki University Central Hospital and University of Helsinki PO Box 281, Helsinki, HUS, 00029, Finland.
authors.forename: Marjo
authors.initials: M
authors.lastname: Metsäranta
authors.affiliation: The University of Queensland Centre for Clinical Research (UQCCR) and Perinatal Research Centre Brisbane, Queensland, Australia.
authors.forename: Simon
authors.initials: S
authors.lastname: Finnigan
authors.affiliation: Systems Neuroscience Group, QIMR Berghofer Medical Research Institute Brisbane, Queensland, Australia ; School of Psychiatry, University of New South Wales and The Black Dog Institute Sydney, New South Wales, Australia ; The Royal Brisbane and Woman's Hospital Brisbane, Queensland, Australia.
authors.forename: Michael
authors.initials: M
authors.lastname: Breakspear
authors.affiliation: Department of Children's Clinical Neurophysiology, Helsinki University Central Hospital PO Box 280, Helsinki, HUS, 00029, Finland ; Department of Neurological Sciences, University of Helsinki Helsinki, 00014, Finland.
authors.forename: Sampsa
authors.initials: S
authors.lastname: Vanhatalo