title: Correlations between brachial endothelial function and cardiovascular risk factors: a survey of 2,511 Chinese subjects.
abstract: OBJECTIVE
  We examined the relationship of several cardiovascular risk factors (CVRF) to brachial artery flow-mediated dilatation (FMD) in Chinese subjects.
  
  
  METHODS
  This was a cross-sectional study. In 2,511 Chinese adults (age 46.86±9.52 years, 1,891 men and 620 women) recruited from people who underwent health screening at The Third Xiangya Hospital, patients' CVRF [age, body mass index (BMI), waist circumference (WC), blood pressure (BP), cholesterol parameters, creatinine (Cr), uric acid (UA), glucose level and smoking] and prevalence of present disease (hypertension, diabetes mellitus, coronary heart disease and hyperlipidemia) were investigated.
  
  
  RESULTS
  Multivariate analysis revealed that FMD negative correlated with age (β=-0.29, P<0.001), gender (β=-0.12, P<0.001), BMI (β=-0.12, P=0.001), WC (β=-0.10, P=0.011), systolic BP (SBP) (β=-0.12, P<0.001), fasting glucose (β=-0.04, P=0.009), total cholesterol (TC) (β=-0.04, P=0.014), smoking (β=-0.05, P=0.003), and baseline brachial artery diameter (β=-0.35, P<0.001). FMD decreased with increasing age in both genders. In women, FMD was higher than men and age-related decline in FMD was steepest after age 40; FMD was similar in men above 55 years old.
  
  
  CONCLUSIONS
  In Chinese subjects, FMD may be a usefully marker of CVRF. Age, gender, BMI, WC, SBP, fasting glucose, TC, smoking, and baseline brachial artery diameter were independent variables related to the impairment of FMD. The influence of CVRF on endothelial function is more in women than men.
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ping-Ting
authors.initials: PT
authors.lastname: Yang
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Wang
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Cao
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Liu-Xin
authors.initials: LX
authors.lastname: Wu
authors.affiliation: 1 Department of Healthy Management Center, 2 The Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha 410013, China.
authors.forename: Zhi-Heng
authors.initials: ZH
authors.lastname: Chen
keywords: Endothelial function; brachial artery flow-mediated dilatation (FMD); cardiovascular risk factors (CVRF)