title: CATH: comprehensive structural and functional annotations for genome sequences.
abstract: The latest version of the CATH-Gene3D protein structure classification database (4.0, http://www.cathdb.info) provides annotations for over 235,000 protein domain structures and includes 25 million domain predictions. This article provides an update on the major developments in the 2 years since the last publication in this journal including: significant improvements to the predictive power of our functional families (FunFams); the release of our 'current' putative domain assignments (CATH-B); a new, strictly non-redundant data set of CATH domains suitable for homology benchmarking experiments (CATH-40) and a number of improvements to the web pages.
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK i.sillitoe@ucl.ac.uk.
authors.forename: Ian
authors.initials: I
authors.lastname: Sillitoe
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Tony E
authors.initials: TE
authors.lastname: Lewis
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Alison
authors.initials: A
authors.lastname: Cuff
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Sayoni
authors.initials: S
authors.lastname: Das
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Ashford
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Natalie L
authors.initials: NL
authors.lastname: Dawson
authors.affiliation: London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Furnham
authors.affiliation: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
authors.forename: Roman A
authors.initials: RA
authors.lastname: Laskowski
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: David
authors.initials: D
authors.lastname: Lee
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Lees
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Sonja
authors.initials: S
authors.lastname: Lehtinen
authors.affiliation: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
authors.forename: Romain A
authors.initials: RA
authors.lastname: Studer
authors.affiliation: European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
authors.forename: Janet
authors.initials: J
authors.lastname: Thornton
authors.affiliation: Institute of Structural and Molecular Biology, UCL, 636 Darwin Building, Gower Street, WC1E 6BT, UK.
authors.forename: Christine A
authors.initials: CA
authors.lastname: Orengo
mesh_terms: D030562:Databases, Protein; D023281:Genomics; D020407:Internet; D058977:Molecular Sequence Annotation; D017434:Protein Structure, Tertiary / Q000235:genetics; D011506:Proteins / Q000145:classification
chemical_list: D011506:Proteins