title: T-ALL pathogenesis requires a NOTCH1-driven MYC enhancer.
abstract: A NOTCH1-bound MYC enhancer is necessary for normal T-cell development and NOTCH1-induced T-ALL.
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004742:Enhancer Elements, Genetic; D006801:Humans; D051379:Mice; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics* / Q000378:metabolism; D051881:Receptor, Notch1 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology
chemical_list: C489427:MYC protein, human; C497761:NOTCH1 protein, human; D016271:Proto-Oncogene Proteins c-myc; D051881:Receptor, Notch1