title: Highly enantioselective reaction of 2-oxindoles with (3-indolyl)methanols by cooperative catalysis of a Lewis acid and organocatalyst.
abstract: An efficient cooperative biscinchona alkaloid and Lewis acid catalytic system was developed in the enantioselective α-alkylation of 2-oxindoles with (3-indolyl)(phenyl)methanols to provide (2-oxindole)-linker-indole derivatives in good yields (70-83%) with high enantioselectivities (81%-92%).
authors.affiliation: Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. lliu@iccas.ac.cn.
authors.forename: Chuan-Li
authors.initials: CL
authors.lastname: Ren
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Xing-Yong
authors.initials: XY
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Xuan
authors.forename: Feng
authors.initials: F
authors.lastname: Wei
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Huang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Liu
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D000432:Methanol / Q000031:analogs & derivatives / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D007211:Indoles; D058116:Lewis Acids; D000078183:Oxindoles; C022960:2-oxindole; D000432:Methanol