title: The therapeutic effect of rhMK on osteoarthritis in mice, induced by destabilization of the medial meniscus.
abstract: Osteoarthritis (OA) is a worldwide disease in aged people, causing not only physical suffering to the patients themselves, but also a great burden on their families and on society. Here we used a mouse OA model induced by destabilization of the medial meniscus (DMM), and studied the therapeutic effect of recombinant human midkine (rhMK) on this OA model. Our results indicated that the DMM surgery induced mechanical allodynia and locomotor activity obstacles, together with cartilage injury in the C57BL/6 mice. The rhMK treatment mitigated the OA related mechanical allodynia, improved locomotor activity capacity, and prevented degradation of the cartilage. Considering the safety issue of rhMK used as a biologic, we also inspected the main organs in the rhMK treated mice throughout the process and found no pathological change. These results suggest that rhMK could be used as a biologic to treat OA or OA related pain.
authors.affiliation: School of Agriculture and Biology, Shanghai Jiao Tong University.
authors.forename: Chuanying
authors.initials: C
authors.lastname: Xu
authors.forename: Shunying
authors.initials: S
authors.lastname: Zhu
authors.forename: Mingyuan
authors.initials: M
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D006930:Hyperalgesia / Q000188:drug therapy* / Q000473:pathology; D007719:Knee Joint / Q000473:pathology; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D000078792:Midkine; D009043:Motor Activity / Q000187:drug effects; D009414:Nerve Growth Factors / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000473:pathology; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D000700:Analgesics; C066254:MDK protein, human; D009414:Nerve Growth Factors; D011994:Recombinant Proteins; D000078792:Midkine