title: Loss of PRC2 function promotes MPNST pathogenesis.
abstract: Genetic inactivation of PRC2 components, NF1, and CDKN2A are frequently detected in MPNSTs.
mesh_terms: D045744:Cell Line, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D006801:Humans; D009154:Mutation; D009363:Neoplasm Proteins; D018317:Nerve Sheath Neoplasms / Q000235:genetics*; D025542:Neurofibromin 1 / Q000235:genetics; D063151:Polycomb Repressive Complex 2 / Q000235:genetics*; D014157:Transcription Factors
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins; D025542:Neurofibromin 1; C430461:SUZ12 protein, human; D014157:Transcription Factors; D063151:Polycomb Repressive Complex 2