title: Effect of the microtubule-associated protein tau on dynamics of single-headed motor proteins KIF1A.
abstract: Intracellular transport based on molecular motors and its regulation are crucial to the functioning of cells. Filamentary tracks of the cells are abundantly decorated with nonmotile microtubule-associated proteins, such as tau. Motivated by experiments on kinesin-tau interactions [Dixit et al., Science 319, 1086 (2008)] we developed a stochastic model of interacting single-headed motor proteins KIF1A that also takes into account the interactions between motor proteins and tau molecules. Our model reproduces experimental observations and predicts significant effects of tau on bound time and run length which suggest an important role of tau in regulation of kinesin-based transport.
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and CONICET, Medina Allende s/n, Ciudad Universitaria, 5000 Córdoba, Argentina.
authors.forename: J
authors.initials: J
authors.lastname: Sparacino
authors.affiliation: Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC-CONICET and FoNCyT, Friuli 2434, Barrio Parque Vélez Sarsfield, 5016 Córdoba, Argentina.
authors.forename: M G
authors.initials: MG
authors.lastname: Farías
authors.affiliation: Facultad de Matemática, Astronomía y Física, Universidad Nacional de Córdoba and CONICET, Medina Allende s/n, Ciudad Universitaria, 5000 Córdoba, Argentina.
authors.forename: P W
authors.initials: PW
authors.lastname: Lamberti
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D016547:Kinesins / Q000737:chemistry* / Q000648:ultrastructure; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000648:ultrastructure; D009038:Motion; D011485:Protein Binding; D011487:Protein Conformation; D016875:tau Proteins / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: C094065:KIF1A protein, human; D020409:Molecular Motor Proteins; D016875:tau Proteins; D016547:Kinesins