title: [Association between gene polymorphism of CD40 gene and coronary artery lesion in Kawasaki disease].
abstract: OBJECTIVE
  To study the association between two single nucleotide polymorphisms (rs4810485 and rs1535045 in CD40 gene) and Kawasaki disease (KD) in Han Chinese children.
  
  
  METHODS
  A case-control study was performed on 184 children with KD and 206 normal controls. The polymorphisms of two SNPs in CD40 gene were detected using PCR-RFLP.
  
  
  RESULTS
  There were no significant differences in the genotype distribution and allele frequency of SNP rs4810485 in CD40 gene between the KD and normal groups (P&gt;0.05). The genotype distribution of SNP rs1535045 in CD40 gene in the KD group was significantly different from the control group (P&lt;0.05). T allele of SNP rs1535045 was shown as a risk factor for development of KD (OR=1.592, 95%CI: 1.182-2.144, P=0.004). There were no association between the polymorphisms of the two SNPs and coronary artery lesions (P&gt;0.05).
  
  
  CONCLUSIONS
  SNP rs1535045 may be associated with the development of KD in Han Chinese children, while SNP rs4810485 may not.
authors.affiliation: Department of Pediatrics, Xianning Central Hospital, Xianning, Hubei 437100, China. Chengsc236@126.com.
authors.forename: Shou-Chao
authors.initials: SC
authors.lastname: Cheng
authors.forename: Yan-Yang
authors.initials: YY
authors.lastname: Cheng
authors.forename: Jin-Long
authors.initials: JL
authors.lastname: Wu
mesh_terms: D019013:CD40 Antigens / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019013:CD40 Antigens