title: [The effect of Xuebijing injection on immune regulation in SIRS patients].
abstract: OBJECTIVE
  To investgate the effect of Xuebijing Injection on immune regulation in patients with systemic inflammatory response syndrome (SIRS).
  
  
  METHODS
  56 SIRS patients admitted to the ICU of Guizhou Provincial Hospital from January 2013 to December 2013 were included in this study. The patients were randomly divided into a control (C) and a treatment (T) group. Patients in C group received routine treatment; while patients in T group received additional Xuebijing Injection 50 mL Bid. The following indicators were recorded and compared between the two groups before and 4 and 7 days after treatments: CD4+, CD8+, CD4+/CD8+, monocytes CD14+/human leukocyte antigen-DR (HLA-DR), score of acute physiology and chronic health evaluation II (APACHE II), heart rate, white blood cells, body temperature, respiration rate, and MODS (7 d after treatment only).
  
  
  RESULTS
  No differences were found between the two groups before treatments (P > 0.05). T Group had higher levels of CD4+, CD8, CD4+/CD8+ and monocytes CD14+/HLA-DR than C group at 4 and 7 d after treatments (P < 0.05). T group also had higher levels of improvement in vital indicators compared with C group (P < 0.05). No significant difference in incidence of multiple organ dysfunction syndrome (MODS) was found between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  Xuebijing Injection can regulate immune function of patients with SIRS.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Kun
authors.initials: K
authors.lastname: Li
authors.forename: Song-Song
authors.initials: SS
authors.lastname: Zhang
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Fu
authors.forename: Xian-Qing
authors.initials: XQ
authors.lastname: Shi
mesh_terms: D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006684:HLA-DR Antigens; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007267:Injections; D009000:Monocytes / Q000276:immunology; D009102:Multiple Organ Failure; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D004365:Drugs, Chinese Herbal; D006684:HLA-DR Antigens; D007155:Immunologic Factors; C549376:Xuebijing