title: [Persistant perfluorinated compounds cause immunotoxic effects].
abstract: Perfluorinated compounds are highly stable and useful industrial chemicals. Both perfluorooctane sulfonic acid and perfluorooctanoic acid cause immunotoxic effects in animal models at serum concentrations similar to human levels. In children who have undergone routine vaccinations, serum concentrations of these substances are inversely associated with concentrations of antibodies against diphtheria and tetanus. Prevention of such effects will require a decrease of exposure limits by at least 100-fold. Immunotoxicity is not included in routine testing of industrial chemicals but urgently needs attention.
authors.affiliation: Afdeling for Miljømedicin, Syddansk Universitet, J.B. Winsløwsvej 17A, 5000 Odense C. pgrand@sdu.dk.
authors.forename: Carsten
authors.initials: C
authors.lastname: Heilmann
authors.forename: Lise
authors.initials: L
authors.lastname: Jensen
authors.forename: Pal
authors.initials: P
authors.lastname: Weihe
authors.forename: Flemming
authors.initials: F
authors.lastname: Nielsen
authors.forename: Lisbeth E
authors.initials: LE
authors.lastname: Knudsen
authors.forename: Esben
authors.initials: E
authors.lastname: Budtz-Jørgensen
authors.forename: Kåre
authors.initials: K
authors.lastname: Mølbak
authors.forename: Philippe
authors.initials: P
authors.lastname: Grandjean
mesh_terms: D017738:Alkanesulfonic Acids / Q000097:blood / Q000633:toxicity*; D000917:Antibody Formation / Q000187:drug effects; D002210:Caprylates / Q000097:blood / Q000633:toxicity*; D002648:Child; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000276:immunology; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage / Q000276:immunology; D005466:Fluorocarbons / Q000097:blood / Q000633:toxicity*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D000922:Immunotoxins / Q000097:blood; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000276:immunology; D014611:Vaccination
chemical_list: D017738:Alkanesulfonic Acids; D002210:Caprylates; D004168:Diphtheria Toxoid; D022422:Diphtheria-Tetanus Vaccine; D005466:Fluorocarbons; D000922:Immunotoxins; D013745:Tetanus Toxoid; C023036:perfluorooctanoic acid; C076994:perfluorooctane sulfonic acid