title: Lessons from rodent models in celiac disease.
abstract: Over the past 25 years, studies led in humans have considerably improved our understanding of celiac disease, a complex disease that is generally defined as an autoimmune-like enteropathy induced by dietary gluten in genetically predisposed individuals. Recently, large efforts were also invested in the development of mouse models in order to explore pathogenic hypotheses, and also with the goal to design pretherapeutic models that could be used to test innovative therapies. Yet, modeling this complex multifactorial disease has been a very challenging task. Herein, we review how approaches in rodents have provided insight into celiac disease pathophysiology and also highlight the difficulties met to fully recapitulate the human disease.
authors.affiliation: 1] INSERM UMR1163, Laboratory of Intestinal Immunity, Institut Imagine, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Korneychuk
authors.affiliation: 1] INSERM UMR1163, Laboratory of Intestinal Immunity, Institut Imagine, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Meresse
authors.affiliation: 1] INSERM UMR1163, Laboratory of Intestinal Immunity, Institut Imagine, Paris, France [2] Université Paris Descartes-Sorbonne Paris Cité and Institut Imagine, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Cerf-Bensussan
mesh_terms: D000818:Animals; D002446:Celiac Disease / Q000276:immunology*; D004032:Diet; D004195:Disease Models, Animal; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology; D006801:Humans; D051379:Mice; D051381:Rats
chemical_list: D005983:Glutens