title: Adolescent neighborhood quality predicts adult dACC response to social exclusion.
abstract: Neuroimaging studies using the social-exclusion paradigm Cyberball indicate increased dorsal anterior cingulate cortex (dACC) and right insula activity as a function of exclusion. However, comparatively less work has been done on how social status factors may moderate this finding. This study used the Cyberball paradigm with 85 (45 females) socio-economically diverse participants from a larger longitudinal sample. We tested whether neighborhood quality during adolescence would predict subsequent neural responding to social exclusion in young adulthood. Given previous behavioral studies indicating greater social vigilance and negative evaluation as a function of lower status, we expected that lower adolescent neighborhood quality would predict greater dACC activity during exclusion at young adulthood. Our findings indicate that young adults who lived in low-quality neighborhoods in adolescence showed greater dACC activity to social exclusion than those who lived in higher quality neighborhoods. Lower neighborhood quality also predicted greater prefrontal activation in the superior frontal gyrus, dorsal medial prefrontal cortex and the middle frontal gyrus, possibly indicating greater regulatory effort. Finally, this effect was not driven by subsequent ratings of distress during exclusion. In sum, adolescent neighborhood quality appears to potentiate neural responses to social exclusion in young adulthood, effects that are independent of felt distress.
authors.affiliation: University of Virginia, Charlottesville, VA, USA, Bradley University, Peoria, IL, USA, and Mclean Hospital/Harvard Medical School, Boston, MA, USA mzg7uv@virginia.edu.
authors.forename: Marlen Z
authors.initials: MZ
authors.lastname: Gonzalez
authors.affiliation: University of Virginia, Charlottesville, VA, USA, Bradley University, Peoria, IL, USA, and Mclean Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Lane
authors.initials: L
authors.lastname: Beckes
authors.affiliation: University of Virginia, Charlottesville, VA, USA, Bradley University, Peoria, IL, USA, and Mclean Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Chango
authors.affiliation: University of Virginia, Charlottesville, VA, USA, Bradley University, Peoria, IL, USA, and Mclean Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Allen
authors.affiliation: University of Virginia, Charlottesville, VA, USA, Bradley University, Peoria, IL, USA, and Mclean Hospital/Harvard Medical School, Boston, MA, USA.
authors.forename: James A
authors.initials: JA
authors.lastname: Coan
mesh_terms: D000293:Adolescent; D001143:Arousal; D002540:Cerebral Cortex / Q000502:physiology*; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008297:Male; D010146:Pain / Q000523:psychology; D017397:Prefrontal Cortex / Q000502:physiology; D012929:Psychological Distance; D012111:Residence Characteristics; D012923:Social Class; D012931:Social Environment; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Cyberball; dACC; fMRI; neighborhood SES; social exclusion