title: Palladium-catalyzed oxidative C-H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones.
abstract: A palladium-catalyzed cascade cross-coupling of N-nitroso-anilines and toluene derivatives for the direct synthesis of N-alkyl-2-aminobenzophenones is described. N-nitroso groups in anilines can act as the traceless directing groups while toluene derivatives can serve as effective acyl precursors under mild reaction conditions.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. luohb77@mail.sysu.edu.cn.
authors.forename: Yinuo
authors.initials: Y
authors.lastname: Wu
authors.forename: Ling-Jun
authors.initials: LJ
authors.lastname: Feng
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
authors.forename: Hai-Bin
authors.initials: HB
authors.lastname: Luo
mesh_terms: D000215:Acylation; D000814:Aniline Compounds / Q000737:chemistry*; D001577:Benzophenones / Q000138:chemical synthesis*; D002384:Catalysis; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D014050:Toluene / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001577:Benzophenones; D014050:Toluene; D010165:Palladium