title: Quantification of myocardial blood flow using PET to improve the management of patients with stable ischemic coronary artery disease.
abstract: Cardiac PET has been evolving over the past 30 years. Today, it is accepted as a valuable imaging modality for the noninvasive assessment of coronary artery disease. PET has demonstrated superior diagnostic accuracy for the detection of coronary artery disease compared with single-photon emission computed tomography, and also has a well-established prognostic value. The routine addition of absolute quantification of myocardial blood flow increases the diagnostic accuracy for three-vessel disease and provides incremental functional and prognostic information. Moreover, the characterization of the vasodilator capacity of the coronary circulation may guide proper decision-making and monitor the effects of lifestyle changes, exercise training, risk factor modification or medical therapy for improving regional and global myocardial blood flow. This type of image-guided approach to individualized patient therapy is now attainable with the routine use of cardiac PET flow reserve imaging.
authors.affiliation: MFI program, National Cardiac PET Center, Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, ON, Canada.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohira
authors.forename: Taylor
authors.initials: T
authors.lastname: Dowsley
authors.forename: Girish
authors.initials: G
authors.lastname: Dwivedi
authors.forename: Robert A
authors.initials: RA
authors.lastname: deKemp
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Chow
authors.forename: Terrence D
authors.initials: TD
authors.lastname: Ruddy
authors.forename: Ross A
authors.initials: RA
authors.lastname: Davies
authors.forename: Jean
authors.initials: J
authors.lastname: DaSilva
authors.forename: Rob S B
authors.initials: RS
authors.lastname: Beanlands
authors.forename: Renee
authors.initials: R
authors.lastname: Hessian
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000503:physiopathology; D003326:Coronary Circulation / Q000502:physiology*; D005544:Forecasting; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011379:Prognosis
keywords: CAD; CBF; CFR; CMR; CT; MBF; PET; SPECT