title: The use of very high-doses of baclofen for the treatment of alcohol-dependence: a case series.
abstract: Baclofen, particularly high-dose baclofen, has recently emerged as a treatment of major interest for alcohol-dependence. However, baclofen has many potentially dangerous side effects, and the maximal dose of baclofen that may be used is a matter of discussion. Here, the author analyses the medical charts of the last 100 patients seen in his clinic, 17 of whom have been taking a very high dose of baclofen, which is to say, more than 300 mg/day. The analysis of the charts shows that the very high-doses baclofen were justified in almost all the cases. Side effects are analyzed.
authors.affiliation: Groupe Hospitalier Paul-Guiraud , Villejuif , France.
authors.forename: Renaud
authors.initials: R
authors.lastname: de Beaurepaire
keywords: abstinence; addiction; alcoholism; side effect; treatment