title: Reproducibility of exhaled nitric oxide measurements in overweight and obese adults.
abstract: BACKGROUND
  Exhaled nitric oxide is a noninvasive measure of airway inflammation that can be detected by a handheld device. Obesity may influence the reproducibility of exhaled nitric oxide measurements, by - for instance - decreased expiratory reserve volume.
  
  
  RESULTS
  We analyzed triple exhaled nitric oxide measurements from 553 participants (aged 45 to 65 years with a body mass index ≥27 kg/m2) of the Netherlands Epidemiology of Obesity Study. The interclass correlation coefficient (single measurement reliability) was 0.965 (95% CI: 0.960, 0.970).
  
  
  CONCLUSIONS
  We conclude that for assessment of exhaled nitric oxide in large cohorts of overweight and obese adults a single measurement suffices.
authors.affiliation: Department of Pulmonology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, the Netherlands. W.Thijs@lumc.nl.
authors.forename: Willemien
authors.initials: W
authors.lastname: Thijs
authors.forename: Renée
authors.initials: R
authors.lastname: de Mutsert
authors.forename: Saskia
authors.initials: S
authors.lastname: le Cessie
authors.forename: Pieter S
authors.initials: PS
authors.lastname: Hiemstra
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: Saskia
authors.initials: S
authors.lastname: Middeldorp
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Rabe
mesh_terms: D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods*; D045853:Exhalation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009569:Nitric Oxide / Q000378:metabolism*; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D015203:Reproducibility of Results
chemical_list: D009569:Nitric Oxide