title: Deep and quantitative top-down proteomics in clinical and translational research.
abstract: It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.
authors.affiliation: Northwestern University, 2145 N. Sheridan Rd, Evanston, IL, 60208, USA.
authors.forename: Neil L
authors.initials: NL
authors.lastname: Kelleher
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thomas
authors.forename: Ioanna
authors.initials: I
authors.lastname: Ntai
authors.forename: Philip D
authors.initials: PD
authors.lastname: Compton
authors.forename: Richard D
authors.initials: RD
authors.lastname: LeDuc
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D035843:Biomedical Research; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D059748:Proteolysis; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
chemical_list: D015415:Biomarkers; D011506:Proteins; D020543:Proteome
keywords: clinical; proteomics; quantitative; top-down; translational