title: Effects of aging on renal function and regenerative capacity.
abstract: Along with the increase in aging of our population, the proportion of older patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) is on the rise as a result of the accumulation of comorbidities as well as biological processes associated with aging. Older patients with acute kidney injury (AKI) comprise an increasing proportion of patients with CKD/ESRD as well. In this review, we will discuss biological processes of aging that predispose patients to AKI and CKD.
authors.affiliation: Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, Va., USA.
authors.forename: Emaad M
authors.initials: EM
authors.lastname: Abdel-Rahman
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
mesh_terms: D058186:Acute Kidney Injury / Q000473:pathology / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000818:Animals; D016922:Cellular Senescence; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000473:pathology; D005260:Female; D005966:Glucuronidase / Q000502:physiology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007668:Kidney / Q000254:growth & development / Q000473:pathology / Q000502:physiology*; D007674:Kidney Diseases / Q000453:epidemiology; D000090265:Klotho Proteins; D008297:Male; D000077205:Pioglitazone; D012038:Regeneration / Q000502:physiology*; D015427:Reperfusion Injury / Q000473:pathology / Q000503:physiopathology; D059505:Telomere Homeostasis; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D045162:Thiazolidinediones; D005966:Glucuronidase; D000090265:Klotho Proteins; D000077205:Pioglitazone