title: Rhodium-catalyzed enantioselective hydrogenation of tetrasubstituted α-acetoxy β-enamido esters: a new approach to chiral α-hydroxyl-β-amino acid derivatives.
abstract: Asymmetric hydrogenation of tetrasubtitued α-acetoxy β-enamido esters with rhodium catalysts based on chiral diphosphine ligands provides an efficient and concise route to the synthesis of chiral α-hydroxyl-β-amino acid derivatives in excellent enantioselectivities. The products are valuable chiral building blocks in many biologically active compounds and have important applications in organic synthesis.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University , Wuhan, Hubei 430072, China.
authors.forename: Qingli
authors.initials: Q
authors.lastname: Wang
authors.forename: Wenhua
authors.initials: W
authors.lastname: Huang
authors.forename: Haoquan
authors.initials: H
authors.lastname: Yuan
authors.forename: Qin
authors.initials: Q
authors.lastname: Cai
authors.forename: Liming
authors.initials: L
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006865:Hydrogenation; D006878:Hydroxides / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D004952:Esters; D006878:Hydroxides; C031356:hydroxide ion; D012238:Rhodium