title: Redistribution of body composition in patients with Graves' disease after iodine-131 treatment.
abstract: OBJECTIVE
  The objective of this study was to investigate body composition redistribution at 3 months after radioactive iodine therapy (RAI).
  
  
  METHODS
  Eighty patients with Graves' disease (GD) for RAI and 18 volunteers were recruited. All patients underwent thyroid status test and dual-energy x-ray absorptiometry at baseline and 3 months after RAI. According to the second thyroid status test, patients were divided into the following groups: A, with aggravated hyperthyroidism; B-1, with improved hyperthyroidism; B-2, with euthyroidism; and B-3, with hypothyroidism.
  
  
  RESULTS
  Total lean mass (LM) but fat mass (FM) and bone mineral content (BMC) of whole GD patients after RAI recovered to be not different with controls. Compared with baseline, in group A, FM in the left leg increased, and LM in left arm, right arm, trunk and total LM decreased (P<0.05). In B-2, FM in the head increased, and LM in the head, right arm, trunk and total LM increased (P<0.05). In B-3, FM in the right leg and total body fat percentage decreased, but FM in the head, android-to-gynoid fat ratio and body mass index increased (P<0.05); LM of all sites, weight and total mass increased (P<0.05); BMC in lumbar spine and left leg, and total BMC decreased (P<0.05). Body composition of unmentioned sites was retained after RAI in each group (P>0.05).
  
  
  CONCLUSIONS
  Replenishment of LM gets priority rather than FM and BMC during the first 3 months after RAI, and the increase in LM starts from the upper body; head is the regional site in which FM recovery occurs first.
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: L-J
authors.initials: LJ
authors.lastname: Xie
authors.affiliation: Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Zhou
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: J-F
authors.initials: JF
authors.lastname: Li
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: F
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: F-W
authors.initials: FW
authors.lastname: Zeng
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: L-P
authors.initials: LP
authors.lastname: Qin
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Yuan
authors.affiliation: Department of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou City, China.
authors.forename: M-H
authors.initials: MH
authors.lastname: Cheng
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity / Q000208:ethnology / Q000528:radiation effects; D000328:Adult; D001823:Body Composition / Q000528:radiation effects; D015519:Bone Density; D001846:Bone Development / Q000528:radiation effects; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006111:Graves Disease / Q000208:ethnology / Q000532:radiotherapy* / Q000534:rehabilitation; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology; D007037:Hypothyroidism / Q000453:epidemiology / Q000208:ethnology / Q000209:etiology / Q000503:physiopathology; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D024510:Muscle Development / Q000528:radiation effects; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000627:therapeutic use*; D013961:Thyroid Gland / Q000503:physiopathology / Q000528:radiation effects*; D051598:Whole Body Imaging
chemical_list: D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals