title: Bismuth(III) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6].
abstract: Reaction of BiPh3 or Bi(O(t)Bu)3 with benzohydroxamic acid (H2-BHA) results in formation of novel mono- and di-anionic hydroxamato complexes; [Bi2(BHA)3]∞ 1, [Bi(H-BHA)3] 2, [Bi(BHA)(H-BHA)] 3, all of which display nM activity against Helicobacter pylori. Subsequent dissolution of [Bi2(BHA)3]∞ in DMSO/toluene results in hydrolysis to the first structurally authenticated {Bi34} oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6] 4.
authors.affiliation: School of Chemistry, Monash University, Clayton, Melbourne, VIC 3800, Australia. phil.andrews@monash.edu.
authors.forename: Amita
authors.initials: A
authors.lastname: Pathak
authors.forename: Victoria L
authors.initials: VL
authors.lastname: Blair
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ferrero
authors.forename: Michael
authors.initials: M
authors.lastname: Mehring
authors.forename: Philip C
authors.initials: PC
authors.lastname: Andrews
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001729:Bismuth / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D016480:Helicobacter pylori / Q000187:drug effects*; D006868:Hydrolysis; D006877:Hydroxamic Acids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D006877:Hydroxamic Acids; C006696:benzohydroxamic acid; D001729:Bismuth; D004121:Dimethyl Sulfoxide