title: Metal-free iodine(III)-promoted synthesis of isoquinolones.
abstract: A metal-free oxidative cycloaddition reaction of substituted benzamides and alkynes has been developed for the synthesis of isoquinolones by using bis(trifluoracetoxy)iodobenzene (PIFA) and trifluoroacetic acid (TFA). Under mild conditions, a wide variety of isoquinolones were conveniently prepared via oxidative annulation of simple N-methoxybenzamide and diarylacetylene or aryl/alkyl acetylene derivatives in yields up to 87%.
authors.affiliation: State Key Laboratory and Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, China.
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Chen
authors.forename: Yi-Zhou
authors.initials: YZ
authors.lastname: Zhu
authors.forename: Jin-Wang
authors.initials: JW
authors.lastname: Ou
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Jian-Yu
authors.initials: JY
authors.lastname: Zheng
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D061565:Cycloaddition Reaction; D007455:Iodine / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D014269:Trifluoroacetic Acid / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007462:Iodobenzenes; D007546:Isoquinolines; D008670:Metals; D007455:Iodine; D014269:Trifluoroacetic Acid