title: Correlation between lung to thorax transverse area ratio and observed/expected lung area to head circumference ratio in fetuses with left-sided diaphragmatic hernia.
abstract: Observed/expected lung area to head circumference ratio (o/e LHR) and lung to thorax transverse area ratio (LTR) are the sonographic indicators of postnatal outcome in fetuses with congenital diaphragmatic hernia (CDH), and they are not influenced by gestational age. We aimed to evaluate the relationship between these two parameters in the same subjects with fetal left-sided CDH. Fetuses with left-sided CDH managed between 2005 and 2012 were included. Data of LTR and o/e LHR values measured on the same day prior to 33 weeks' gestation in target fetuses were retrospectively collected. The correlation between the two parameters was estimated using the Spearman's rank-correlation coefficient, and linear regression analysis was used to assess the relationship between them. Data on 61 measurements from 36 CDH fetuses were analyzed to obtain a Spearman's rank-correlation coefficient of 0.74 with the following linear equation: LTR = 0.002 × (o/e LHR) + 0.005. The determination coefficient of this linear equation was sufficiently high at 0.712, and the prediction accuracy obtained with this regression formula was considered satisfactory. A good linear correlation between the LTR and the o/e LHR was obtained, suggesting that we can translate the predictive parameters for each other. This information is expected to be useful to improve our understanding of different investigations focusing on LTR or o/e LHR as a predictor of postnatal outcome in CDH.
authors.affiliation: Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Japan.
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hidaka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.forename: Jun
authors.initials: J
authors.lastname: Sasahara
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishii
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Mitsuda
mesh_terms: D000328:Adult; D001837:Body Weights and Measures; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D005865:Gestational Age; D006257:Head / Q000473:pathology*; D065630:Hernias, Diaphragmatic, Congenital / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000473:pathology*; D011296:Prenatal Diagnosis; D013909:Thorax / Q000473:pathology*; D016216:Ultrasonography, Prenatal; D055815:Young Adult
keywords: congenital diaphragmatic hernia; lung hypoplasia; lung to thorax transverse area ratio; observed/expected lung area to head circumference ratio