title: Quantitative multiplexing with nano-self-assemblies in SERS.
abstract: Multiplexed or simultaneous detection of multiple analytes is a valuable tool in many analytical applications. However, complications caused by the presence of interfering compounds in a sample form a major drawback in existing molecular sensor technologies, particularly in multi-analyte systems. Although separating analytes through extraction or chromatography can partially address the problem of interferents, there remains a need for developing direct observational tools capable of multiplexing that can be applied in situ. Surface-enhanced Raman Spectroscopy (SERS) is an optical molecular finger-printing technique that has the ability to resolve analytes from within mixtures. SERS has attracted much attention for its potential in multiplexed sensing but it has been limited in its quantitative abilities. Here, we report a facile supramolecular SERS-based method for quantitative multiplex analysis of small organic molecules in aqueous environments such as human urine.
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry.
authors.forename: Setu
authors.initials: S
authors.lastname: Kasera
authors.affiliation: Nanophotonics Centre, Cavendish Laboratory, University of Cambridge, UK.
authors.forename: Lars O
authors.initials: LO
authors.lastname: Herrmann
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry.
authors.forename: Jesús
authors.initials: J
authors.lastname: del Barrio
authors.affiliation: Nanophotonics Centre, Cavendish Laboratory, University of Cambridge, UK.
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Baumberg
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry.
authors.forename: Oren A
authors.initials: OA
authors.lastname: Scherman
mesh_terms: D015374:Biosensing Techniques; D001952:Bridged-Ring Compounds / Q000737:chemistry; D006801:Humans; D007093:Imidazoles / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry; D018377:Neurotransmitter Agents / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular; D013059:Spectrum Analysis, Raman / Q000379:methods*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D007093:Imidazoles; D018377:Neurotransmitter Agents; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils