title: Daidzein and genistein fail to improve glycemic control and insulin sensitivity in Chinese women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial.
abstract: METHODS
  This randomized, double-blind, and placebo-controlled trial evaluated the effect of isolated daidzein and genistein on glycemic control and insulin sensitivity in 165 Chinese women aged 30-70 with impaired glucose regulation (IGR).
  
  
  RESULTS
  Participants were randomly assigned to one of three groups with a daily dose of 10 g of soy protein plus (i) no addition, (ii) 50 mg of daidzein, or (iii) 50 mg of genistein for 24 wk. Fasting glucose (FG), insulin, and glycosylated hemoglobin (HbA1c ), and glucose concentrations at 30, 60, 120, and 180 min and insulin concentrations at 30, 60, and 120 min after an oral 75-g glucose tolerance test were assessed at baseline and at 12 and 24 wk postintervention. a total of 158 and 151 subjects completed the measures at wk 12 and 24, respectively. There were no significant differences in the changes (%) of FG and the 2-h glucose, HbA1c , fasting, and 2-h insulin or the area under the curve of glucose and insulin between the three treatment groups at wk 12 or 24 (all p > 0.05).
  
  
  CONCLUSIONS
  Neither isolated daidzein nor genistein has a significant effect on glycemic control and insulin sensitivity in Chinese women with IGR over a 6-month supplementation period.
authors.affiliation: Department of Nutrition, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, P. R. China; Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, P. R. China.
authors.forename: Yan-Bin
authors.initials: YB
authors.lastname: Ye
authors.forename: Ai-Ling
authors.initials: AL
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Shu-Yu
authors.initials: SY
authors.lastname: Zhuo
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Guan
authors.forename: Wan-Ping
authors.initials: WP
authors.lastname: Deng
authors.forename: Shi
authors.initials: S
authors.lastname: Fang
authors.forename: Yan-Bing
authors.initials: YB
authors.lastname: Li
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D019833:Genistein / Q000008:administration & dosage*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007529:Isoflavones / Q000008:administration & dosage* / Q000652:urine; D008875:Middle Aged; D009043:Motor Activity; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D019833:Genistein; D006442:Glycated Hemoglobin; D007328:Insulin; D007529:Isoflavones; C004742:daidzein
keywords: Daidzein; Genistein; Glycemic control; Insulin sensitivity; Soy isoflavones