title: Relations between mood characteristics, circadian preferences, and functionality in multiple sclerosis.
abstract: OBJECTIVE
  Multiple sclerosis (MS) is a progressive disorder that results in demyelinization of the nerve fibers of the central nervous system. We aimed to determine chronobiological and mood features in patients with MS.
  
  
  METHODS
  The sample comprised 75 patients with MS (54 women and 21 men) and 50 healthy individuals (38 women and 12 men). Sixty-three patients were relapsing-remitting MS and twelve patients had secondary progressive-type MS. Mood characteristics were assessed using subscales of the Profile of Mood States (POMS). Chronotypical characteristics were determined by the Morningness-Eveningness Questionnaire (MEQ). Univariate and structural equation modeling was applied to untangle the possible connections between variables.
  
  
  RESULTS
  Both relapsing-remitting and secondary progressive patients scored higher on the depression-dejection and fatigue-inertia scales of the POMS than healthy individuals. Circadian preferences did not differ significantly between these groups. Patients using glatiramer acetate and other types of drugs had greater severity of functional impairment measured relative to interferon-beta treatment group. Glatiramer acetate had more negative effects on mood than interferon-beta therapy. This finding may be the result of significantly higher duration of disease and higher symptom severity scores in glatiramer acetate group.
  
  
  CONCLUSIONS
  In the structural equation model, gender was found to be predictive for characteristics of mood.
authors.affiliation: Department of Psychiatry, Yuzuncu Yil University Medicine Faculty , Van , Turkey.
authors.forename: Pinar G
authors.initials: PG
authors.lastname: Ozdemir
authors.forename: Aysel
authors.initials: A
authors.lastname: Milanlioglu
authors.forename: Murat
authors.initials: M
authors.lastname: Boysan
authors.forename: Vedat
authors.initials: V
authors.lastname: Cilingir
authors.forename: Nuri
authors.initials: N
authors.lastname: Aydin
authors.forename: Abdullah
authors.initials: A
authors.lastname: Atli
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D000342:Affective Symptoms / Q000503:physiopathology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D000068717:Glatiramer Acetate / Q000627:therapeutic use; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D007155:Immunologic Factors; D000068717:Glatiramer Acetate; D016899:Interferon-beta
keywords: Multiple sclerosis; circadian preferences; disability; mood