title: The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans.
abstract: Nymphaea hybrid, a water lily from the Nymphaeaceae family, has been found to exhibit some in vivo beneficial effects. In the present study we investigated the lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans. We found that Nymphaea hybrid root extract significantly extended the lifespan of C.elegans and improved its locomotion during aging. Moreover, Nymphaea hybrid root extract increased the resistance of C.elegans to both heat stress and oxidative stress. We found that the ability of Nymphaea hybrid root extract to increase lifespan was independent of its antimicrobial effects and was probably associated with its effects on the reproduction of C.elegans. In addition, the lifespan-extending effects of Nymphaea hybrid root extract were found to be dependent on the insulin/IGF signaling pathway. We also found that total flavones of Nymphaea hybrid could increase survival of C.elegans in both normal and adverse conditions, indicating that total flavones comprise the major fractions with lifespan-extending effects. Therefore, Nymphaea hybrid root extract has lifespan-extending effects in C.elegans and could be developed as a functional food.
authors.affiliation: School of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, 213164, China, cczuzzh@163.com.
authors.forename: Ziheng
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Ting
authors.initials: T
authors.lastname: Lv
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Yusi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Xue
authors.forename: Linsong
authors.initials: L
authors.lastname: Yang
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects*; D000375:Aging / Q000187:drug effects*; D000818:Animals; D017173:Caenorhabditis elegans / Q000187:drug effects*; D047309:Flavones / Q000494:pharmacology*; D006358:Hot Temperature; D007328:Insulin / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects; D008136:Longevity / Q000187:drug effects*; D030721:Nymphaea / Q000737:chemistry*; D018384:Oxidative Stress; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D012098:Reproduction / Q000187:drug effects; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D047309:Flavones; D007328:Insulin; D010936:Plant Extracts