title: TPS-guided interstitial Iodine-125 implantation in patients with oral cavity and maxillofacial carcinomas.
abstract: OBJECTIVE
  To investigate the efficacy as well as the complications involved in the use of interstitial Iodine-125 implantation for the treatment of oral cavity and maxillofacial carcinomas.
  
  
  METHODS
  Fifteen patients with oral cavity and maxillofacial carcinomas received treatment planning system (TPS)-guided interstitial Iodine-125 implantation. The apparent activity per particle ranged from 0.6 mCi (2.22MBq) to 0.7 mCi (2.59MBq). The matched peripheral dose delivered by radioactive seeds ranged from 90 to 120 Gy. The efficacy of the treatment and the postoperative complications were evaluated during follow-up.
  
  
  RESULTS
  The seeds were implanted successfully in all 15 patients and median number of seeds implanted was 36.53. CT scans were performed in all patients at 1-6 months postoperatively. During follow-up at 6-27 months, seed migration occurred and a good local tumor control was achieved with an overall response of 86.7%. No severe side effects were observed.
  
  
  CONCLUSIONS
  TPS-guided interstitial Iodine-125 implantation is an effective and safe procedure with minimal invasiveness for the treatment of oral cavity and maxillofacial carcinomas, and it effectively prevents the recurrence of cancer and short-term lymphatic metastasis.
authors.affiliation: Department of Stomatology, Central Hospital of Xuzhou City, Xuzhou, China. mrocket@126.com.
authors.forename: J
authors.initials: J
authors.lastname: Meng
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: Q-W
authors.initials: QW
authors.lastname: Zhuang
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: Z-P
authors.initials: ZP
authors.lastname: Li
authors.forename: Q-P
authors.initials: QP
authors.lastname: Gu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects / Q000379:methods*; D005153:Facial Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes