title: [Gastric carcinoma is the most frequent Epstein-Barr virus-associated malignancy].
abstract: Epstein-Barr virus (EBV) is associated with 8% of gastric carcinomas (GC) worldwide, being the most frequent EBV-associated malignancy with 80,000 new cases per year. The association is based on the presence of clonal EBV products in gastric tumour cells, and elevated EBV antibodies in pre-diagnostic sera. EBV-associated GC are twice as common in males and often associated to cancer in the cardia-region. Gastric surgery increases the risk significantly. Until now, no clear interaction between Helicobacter pylori, the single most important risk factor for GC, and EBV has been established.
authors.forename: Trine
authors.initials: T
authors.lastname: Boysen
authors.affiliation: Onkologisk Klinik, Rigshospitalet, Blegdamsvej 9, 2100 København Ø. jeppe.friborg@regionh.dk
authors.forename: Jeppe
authors.initials: J
authors.lastname: Friborg
mesh_terms: D002277:Carcinoma / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000821:virology*