title: Very low birthweight bronchopulmonary dysplasia survivors show no substantial association between lung function and current inflammatory markers.
abstract: OBJECTIVE
  The role of inflammation in the bronchopulmonary dysplasia (BPD) survivors is indistinct. We evaluated lung function in relation to inflammatory markers in plasma, exhaled breath condensate and exhaled air in school-aged very low birthweight (VLBW) survivors with and without radiographic BPD.
  
  
  METHODS
  Pre- and postbronchodilator impulse oscillometry were performed by 21 six to 14-year-old VLBW children with radiographic BPD, 19 VLBW children without radiographic BPD and 19 age-matched nonasthmatic term controls. Eosinophilic cationic protein, interleukins 6 and 8, adiponectin, adipsin, leptin and resistin in plasma, leukotriene B4 and 8-isoprostane in exhaled breath condensate, and bronchial and alveolar nitric oxide output were measured.
  
  
  RESULTS
  Abnormal lung function was found in 12.5% of the former VLBW children. Airway resistance at 5 Hz was highest in the radiographic BPD, but bronchodilator responses were most prominent in the non-BPD group. Plasma adiponectin had a modest positive correlation with obstruction and with bronchodilator responses, and alveolar nitric oxide and plasma interleukin 6 with bronchodilator responses.
  
  
  CONCLUSIONS
  Very low birthweight children with radiographic BPD had poorest lung function. The most pronounced bronchodilator responses were found in VLBW children without radiographic BPD. Current detected inflammatory markers had only a minor association with lung function in school-aged BPD survivors.
authors.affiliation: Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Tampere Center for Child Health Research, Tampere University Hospital and University of Tampere, Tampere, Finland.
authors.forename: Piia
authors.initials: P
authors.lastname: Suursalmi
authors.forename: Tarja
authors.initials: T
authors.lastname: Kopeli
authors.forename: Päivi
authors.initials: P
authors.lastname: Korhonen
authors.forename: Lauri
authors.initials: L
authors.lastname: Lehtimäki
authors.forename: Riina
authors.initials: R
authors.lastname: Nieminen
authors.forename: Tiina
authors.initials: T
authors.lastname: Luukkaala
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
authors.forename: Marita
authors.initials: M
authors.lastname: Paassilta
authors.forename: Outi
authors.initials: O
authors.lastname: Tammela
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism*; D001997:Bronchopulmonary Dysplasia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007249:Inflammation / Q000378:metabolism*; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011859:Radiography; D012189:Retrospective Studies; D017741:Survivors
chemical_list: D015415:Biomarkers
keywords: Adipokines; Bronchopulmonary dysplasia; Impulse oscillometry; Inflammation; Lung function; Very low birthweight