title: Methyl substitution regulates the enantioselectivity of supramolecular complex binding to human telomeric G-quadruplex DNA.
abstract: Chiral supramolecular compounds with substituents at different positions show different binding properties with human telomeric G-quadruplex DNA. These different positions of methyl substitution in chiral supramolecular compounds can modulate their enantioselectivity and structural preference when binding with human telomeric G-quadruplex DNA.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin 130022 (P. R. China).
authors.forename: Bailu
authors.initials: B
authors.lastname: Xu
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Hisae
authors.initials: H
authors.lastname: Tateishi-Karimata
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugimoto
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D054856:G-Quadruplexes; D006801:Humans; D008745:Methylation; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D019098:Telomerase / Q000037:antagonists & inhibitors; D016615:Telomere / Q000737:chemistry / Q000378:metabolism
chemical_list: D009942:Organometallic Compounds; D009532:Nickel; D004247:DNA; D019098:Telomerase
keywords: G-quadruplex; chirality; methyl substitution; supramolecular chemistry; telomerase inhibition