title: Benefits of cord blood collection in the prevention of post-partum hemorrhage: a cohort study.
abstract: OBJECTIVE
  The aim of this study was to assess the benefit of umbilical cord drainage through cord blood collection (CBC) for the prevention of post-partum hemorrhage (PPH).
  
  
  METHODS
  This is a retrospective cohort study based on data collected prospectively including all vaginal delivery of singletons pregnancies after 37 weeks of gestation between July 2011 and May 2013 at the Strasbourg Teaching Hospital. We performed a univariate comparison of PPH risk factors with χ(2) tests and then we built multivariate logistic regressions to predict PPH, severe PPH (>1000 cc), retained placenta over 30 min and manual removal of the placenta.
  
  
  RESULTS
  A total of 7810 vaginal deliveries were analyzed, among which 1957 benefited from CBC (25%). In the CBC group, 71 PPH (3.6%) were observed versus 260 (4.4%) in the control group (p = 0.12). In multivariate analysis, after adjustment on PPH risk factors, CBC revealed to be a protective factor of PPH: OR = 0.69 (95% CI 0.50-0.97; p = 0.03). CBC is neither a significant predictive factor of severe PPH, time to placental delivery nor rate of manual removal of the placenta.
  
  
  CONCLUSIONS
  In our study, CBC and thus umbilical cord drainage was a protective factor against PPH but it did reduce neither retained placenta nor the need for artificial placental delivery.
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.|b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Anne
authors.initials: A
authors.lastname: Guillaume
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.|b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Sananès
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.
authors.forename: Valérie
authors.initials: V
authors.lastname: Poirier
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.|b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Adrien
authors.initials: A
authors.lastname: Gaudineau
authors.affiliation: b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Fritz
authors.affiliation: b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Eric
authors.initials: E
authors.lastname: Boudier
authors.affiliation: b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Viville
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.
authors.forename: Germain
authors.initials: G
authors.lastname: Aissi
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.
authors.forename: Romain
authors.initials: R
authors.lastname: Favre
authors.affiliation: a Department of Gynaecology & Obstetrics , CMCO Schiltigheim and.|b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Israel
authors.initials: I
authors.lastname: Nisand
authors.affiliation: b Department of Gynaecology & Obstetrics , Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg , Strasbourg Cedex , France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Langer
mesh_terms: D015331:Cohort Studies; D004322:Drainage; D005260:Female; D005312:Fetal Blood / Q000502:physiology*; D006801:Humans; D007749:Labor Stage, Third; D016015:Logistic Models; D018457:Placenta, Retained; D006473:Postpartum Hemorrhage / Q000517:prevention & control*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Active management; retained placenta; severe post-partum hemorrhage; third stage of labor; umbilical cord drainage