title: New insights into perfluorinated adsorbents for analytical and bioanalytical applications.
abstract: Perfluorinated (F-) adsorbents are generally prepared by bonding perfluoro-functionalized silanes to silica gels. They have been employed for a long time essentially as media for solid-phase extraction of F-molecules or F-tagged molecules in organic chemistry and heterogeneous catalysis. More recently, this approach has been extended to proteomics and metabolomics. Owing to their unique physicochemical properties, namely fluorophilicity and proteinophilicity, and a better understanding of some fundamental aspects of their behavior, new applications of F-adsorbents in the field of environmental science and bio-affinity studies can be envisaged. In this article, we revisit the most important features of F-adsorbents by focusing, in particular, on some basic information that has been recently obtained through (nonlinear) chromatographic studies. Finally, we try to envisage new applications and possibilities that F-adsorbents will allow in the near future.
authors.affiliation: Department of Chemical and Pharmaceutical Sciences, University of Ferrara, 44121, Ferrara, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Marchetti
authors.forename: Roberta
authors.initials: R
authors.lastname: Guzzinati
authors.forename: Martina
authors.initials: M
authors.lastname: Catani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Massi
authors.forename: Luisa
authors.initials: L
authors.lastname: Pasti
authors.forename: Alberto
authors.initials: A
authors.lastname: Cavazzini
mesh_terms: D000327:Adsorption; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D017611:Fluorine Compounds / Q000737:chemistry*; D006801:Humans; D040901:Proteomics / Q000295:instrumentation; D052616:Solid Phase Extraction / Q000295:instrumentation*
chemical_list: D017611:Fluorine Compounds