title: Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer.
abstract: Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C16:1, C18:3, C18:2, C20:4, and C22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.
authors.affiliation: Department of Biophysics and Structural Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College , Beijing , China .
authors.forename: Yaping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Qiu
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengyan
authors.initials: C
authors.lastname: He
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Qin
authors.forename: Yujie
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhili
authors.initials: Z
authors.lastname: Li
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D042241:Early Diagnosis; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated
keywords: Biomarker panel; early detection; gastric cancer; serum; unsaturated free fatty acids