title: Prevalence of HLA-DQA1 alleles and haplotypes in blood donors resident in Wales.
abstract: Two hundred and fifty-four normal blood donors, from a largely UK European population, were sequence-based typed for HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DQA1 and HLA-DQB1. The fit to Hardy-Weinberg expectations was good for all loci (all P values >0.5). Fifteen DQA1 alleles were identified to the second field. DQA1 carriage, allele and DQA1-DQB1 and DRB1-DQA1-DQB1 haplotype frequencies, linkage disequilibria and related values are presented.
authors.affiliation: Welsh Transplantation and Immunogenetics Laboratory, Welsh Blood Service, Pontyclun, Wales, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Lemin
authors.forename: C
authors.initials: C
authors.lastname: Darke
mesh_terms: D000483:Alleles; D001782:Blood Donors; D005787:Gene Frequency; D059848:HLA-DQ alpha-Chains / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015995:Prevalence; D012111:Residence Characteristics; D014852:Wales
chemical_list: D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen