title: Collateral genome instability by DNA damage in mitosis.
abstract: Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to the already dangerous relations between different kinds of genomic instability.
authors.affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands. Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. g.j.p.l.kops@umcutrecht.nl n.jelluma@umcutrecht.nl.
authors.forename: Nannette
authors.initials: N
authors.lastname: Jelluma
authors.affiliation: Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands. Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. Cancer Genomics Netherlands, University Medical Center Utrecht, Utrecht, the Netherlands. g.j.p.l.kops@umcutrecht.nl n.jelluma@umcutrecht.nl.
authors.forename: Geert J P L
authors.initials: GJ
authors.lastname: Kops
mesh_terms: D020090:Chromosome Segregation; D004249:DNA Damage; D042822:Genomic Instability; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics