title: Effect of probe geometry and optical properties on the sampling depth for diffuse reflectance spectroscopy.
abstract: The sampling depth of light for diffuse reflectance spectroscopy is analyzed both experimentally and computationally. A Monte Carlo (MC) model was used to investigate the effect of optical properties and probe geometry on sampling depth. MC model estimates of sampling depth show an excellent agreement with experimental measurements over a wide range of optical properties and probe geometries. The MC data are used to define a mathematical expression for sampling depth that is expressed in terms of optical properties and probe geometry parameters.
authors.affiliation: University of Texas at Austin, Biomedical Engineering, 107 W. Dean Keeton, Austin, Texas 78712, United States.
authors.forename: Ricky
authors.initials: R
authors.lastname: Hennessy
authors.affiliation: University of Texas at Austin, Biomedical Engineering, 107 W. Dean Keeton, Austin, Texas 78712, United States.
authors.forename: Will
authors.initials: W
authors.lastname: Goth
authors.affiliation: University of Texas at Austin, Biomedical Engineering, 107 W. Dean Keeton, Austin, Texas 78712, United States.
authors.forename: Manu
authors.initials: M
authors.lastname: Sharma
authors.affiliation: University of Texas at Austin, Biomedical Engineering, 107 W. Dean Keeton, Austin, Texas 78712, United StatesbUniversity of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, United States.
authors.forename: Mia K
authors.initials: MK
authors.lastname: Markey
authors.affiliation: University of Texas at Austin, Biomedical Engineering, 107 W. Dean Keeton, Austin, Texas 78712, United States.
authors.forename: James W
authors.initials: JW
authors.lastname: Tunnell
mesh_terms: D016880:Anisotropy; D008962:Models, Theoretical; D009010:Monte Carlo Method; D061848:Optical Imaging / Q000295:instrumentation* / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000295:instrumentation* / Q000379:methods*