title: Thermal sensitivity of CLC and TMEM16 chloride channels and transporters.
abstract: Cl(-) transport is of fundamental importance in the most diverse physiological contexts and it is mediated by a variety of ion channels and transporters belonging to different protein families. In particular, the recently identified TMEM16 protein family comprises the long sought Ca(2+)-activated Cl(-) channel (CaCC) and the activity of one of its members, TMEM16A, is highly dependent on temperature and is involved in thermal nociception. Among the other protein families mediating Cl(-) transport, CLC proteins are also regulated by temperature although so far the physiological implications of this dependence are unknown.
authors.affiliation: Istituto di Biofisica, CNR, Genova, Italy.
authors.forename: Michael
authors.initials: M
authors.lastname: Pusch
authors.affiliation: Istituto di Biofisica, CNR, Genova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zifarelli
mesh_terms: D000818:Animals; D027321:Anion Transport Proteins / Q000737:chemistry / Q000378:metabolism*; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D009132:Muscles / Q000378:metabolism; D059225:Nociception; D013697:Thermosensing
chemical_list: D027321:Anion Transport Proteins; D018118:Chloride Channels
keywords: Chloride transport; Gating; Ion channel; Nociception; Temperature dependence; Thermal sensitivity; Transporter