title: Ovarian steroid cell tumor, not otherwise specified: a clinicopathological and immunohistochemical experience of 12 cases.
abstract: OBJECTIVE
  Ovarian steroid cell tumors, not otherwise specified (SCT-NOS) are very rare neoplasms. No large study has been performed in Pakistan to establish the clinicopathological spectrum and immunohistochemical behavior in our region. The purpose of our study was to determine the various clinicopathological and immunohistochemical features of ovarian SCT-NOS along with follow-up in our institution.
  
  
  METHODS
  This was a retrospective observational study. The study was conducted in the Section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan. All reported cases of ovarian SCT-NOS occurring during January 1992 to August 2013 were retrieved. The slides were reviewed and patient demographics, and clinical and pathological features were noted with proforma software. SPSS version 19 was used for all analyses. Data is expressed as absolute values and percentages.
  
  
  RESULTS
  A total of 12 SCT-NOS (2.3%) out of 528 ovarian sex cord stromal tumors were retrieved. The age range was 3-70 years, with mean of 40.75 years. The tumors ranged 2.5-13 cm in size, with a mean size of 6.1 cm. One patient had bilateral tumors. All of the tumors were positive for inhibin and calretinin. Four tumors were negative for Mic-2 (CD99). In two patients, the tumor recurred. Only one patient who had worse pathological features received adjuvant chemotherapy.
  
  
  CONCLUSIONS
  Steroid cell tumors are very rare ovarian tumors in the Pakistani population, mostly presenting in adulthood. Diverse histological differentials exist so special stains and immunohistochemical stains are needed to distinguish these from other tumors.
authors.affiliation: Section of Histopathology, Department of Pathology and Microbiology, Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Saroona
authors.initials: S
authors.lastname: Haroon
authors.forename: Romana
authors.initials: R
authors.lastname: Idrees
authors.forename: Saira
authors.initials: S
authors.lastname: Fatima
authors.forename: Aisha
authors.initials: A
authors.lastname: Memon
authors.forename: Naila
authors.initials: N
authors.lastname: Kayani
mesh_terms: D000071443:12E7 Antigen; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D064032:Calbindin 2 / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007265:Inhibins / Q000032:analysis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000737:chemistry* / Q000473:pathology*; D010154:Pakistan; D012008:Recurrence; D012189:Retrospective Studies; D018312:Sex Cord-Gonadal Stromal Tumors / Q000737:chemistry* / Q000473:pathology*; D047368:Tumor Burden
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D064032:Calbindin 2; D015815:Cell Adhesion Molecules; D007265:Inhibins
keywords: ovarian neoplasm; sex cord stromal tumors; steroid cell tumor-not otherwise specified