title: Asperger's syndrome with unusual cerebral pathology: Case report and literature review.
abstract: A case of Asperger's syndrome with unusual cerebral pathological changes is reported. A 22-year-old male had been having diagnostic Asperger's syndrome since the age of eight and had epilepsy during the past two years. Radiological studies revealed a focal intra-axial cortical and subcortical cerebral lesion with hyper-intensity and non-enhancing contrast in the left frontal lobe. Histological and immunohistochemical studies demonstrated that the lesion consisted of cortical laminar disorganization, neuronal dysmorphism and increased heterotopic neurons in sub-cortical white matter. To our knowledge, this is the first case of Asperger's syndrome with focal cerebral pathological abnormalities rather than mini-columnar changes and the gyrial malformation reported in the literature.
authors.affiliation: Louisiana State University Health Science Center, New Orleans, LA, USA;
authors.forename: Liqiong
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA;
authors.forename: Van
authors.initials: V
authors.lastname: Vo
authors.affiliation: Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Marcus
authors.initials: M
authors.lastname: Ware
authors.affiliation: Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA; ; Department of Neurosurgery, Tulane University School of Medicine, New Orleans, LA, USA.
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Xiong
keywords: Asperger's syndrome; brain; neuropathology