title: The importance of nutritional care in HIV-infected children in resource-limited settings.
abstract: Renewed efforts to provide proper nutritional care are essential for appropriate pediatric HIV management. Current studies support the use of vitamin A and macronutrients that increase caloric and protein intake. With additional research on key issues such as the needed composition and timing for nutritional supplementation, we can determine the best strategies to support the growth and development of HIV-infected children in resource-limited settings. Malnutrition among children is common in the resource-limited settings where HIV infection is most prevalent. While malnutrition is associated with higher morbidity and mortality for HIV-infected children, there is only limited evidence to guide the use of nutritional support for HIV-infected children. The best studied is vitamin A, which is associated with improved mortality and clinical outcomes. Zinc and multivitamin supplementation have not consistently been associated with clinical benefits. Limited research suggests macronutrient supplementation, which typically uses enriched formulas or foods, improves key anthropometrics for HIV-infected children, but the optimal composition of nutrients for supplementation has not been determined. More research is needed to understand the most efficient and sustainable ways to ensure adequate nutrition in this vulnerable population.
authors.affiliation: Department of Pediatrics, Children's Health Services Research, Indiana University School of Medicine, Indianapolis, IN, USA.
authors.forename: Megan S
authors.initials: MS
authors.lastname: McHenry
authors.forename: Edith
authors.initials: E
authors.lastname: Apondi
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Vreeman
mesh_terms: D002648:Child; D015362:Child Nutrition Disorders / Q000150:complications* / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D019587:Dietary Supplements / Q000191:economics / Q000592:standards*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D018977:Micronutrients / Q000008:administration & dosage
chemical_list: D018977:Micronutrients
keywords: HIV; clinical outcomes; growth and development; macronutrients; malnutrition; micronutrients; nutritional supplementation; pediatrics