title: Positive pressure therapy for Meniere's syndrome/disease with a Meniett device: a systematic review of randomised controlled trials.
abstract: BACKGROUND
  Incidence rates of Meniere's syndrome/disease vary considerably from 157 per 100 000 in the United Kingdom to 15 per 100 000 in the United States. A wide range of treatments are used for the treatment of the condition with no consensus on the most effective intervention.
  
  
  OBJECTIVE
  To assess the effectiveness of the Meniett device in reducing the frequency and severity of vertigo in Meniere's syndrome/disease.
  
  
  METHODS
  The Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; BIOSIS Previews; Cambridge Scientific abstracts; ICTRP and additional sources for published and unpublished trials were searched. The date of the last search was 13th May 2014.
  
  
  METHODS
  Four randomised controlled trials (RCTs) were identified that compared the efficacy of the Meniett device versus a placebo device in patients with Meniere's 'disease' as defined by the AAOO criterion.
  
  
  METHODS
  Two review authors independently assessed study eligibility and risk of bias and extracted data. The outcome data were dichotomous for all the included trials.
  
  
  RESULTS
  The four RCTs compared 123 patients with the Meniett device against 114 patients with the placebo device from four RCT's over a follow-up period of 2 weeks to 4 months. There was a significant overall 61% reduction in the frequency of vertigo in both groups (mean no vertigo days per month of 8-3). However, this reduction was not significantly different between the two groups in any study or on meta-analysis [mean difference in vertigo-free days between Meniett and placebo device of 0.77 days over a 1-month period (95% CI - 0.82, 1.83) P = 0.45]. There were also no substantive data to support a greater reduction in the severity of the vertigo or any other outcome with the Meniett device compared with the placebo device.
  
  
  CONCLUSIONS
  No evidence was found to justify the use of the Meniett device in Meniere's syndrome/disease.
authors.affiliation: Department of Otolaryngology, The Royal Infirmary, Edinburgh, UK.
authors.forename: M I
authors.initials: MI
authors.lastname: Syed
authors.affiliation: Department of Otolaryngology, University of Toronto, University Health Network, Toronto, ON, Canada.
authors.forename: J A
authors.initials: JA
authors.lastname: Rutka
authors.affiliation: Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hendry
authors.affiliation: Department of Otolaryngology, MRC/CSO Institute of Hearing Research, Glasgow, UK.
authors.forename: G G
authors.initials: GG
authors.lastname: Browning
mesh_terms: D004867:Equipment Design; D006801:Humans; D008575:Meniere Disease / Q000628:therapy*; D008876:Middle Ear Ventilation / Q000295:instrumentation*; D016032:Randomized Controlled Trials as Topic