title: Effects of off-pump versus on-pump coronary artery bypass grafting: apoptosis, inflammation, and oxidative stress.
abstract: BACKGROUND
  It has been suggested that off-pump coronary artery bypass grafting (CABG) surgery reduces myocardial ischemia-reperfusion injury, postoperative systemic inflammatory response, and oxidative stress. The aim of this study was to measure serum malondialdehyde (MDA), high-sensitivity C-reactive protein (hs-CRP), M30, and M65 levels and to investigate the relationship between M30 levels and oxidative stress and inflammation in patients undergoing on-and off-pump CABG surgery.
  
  
  METHODS
  Fifty patients were randomly assigned to on-pump or off-pump CABG surgery (25 patients off-pump and 25 on-pump CABG surgery), and blood samples were collected prior to surgery, and 30 minutes, 60 minutes, 6 hours, and 24 hours after CABG surgery.
  
  
  RESULTS
  Compared to the on-pump group, serum MDA levels at 30 minutes, 60 minutes, 6 hours, and 24 hours after the CABG surgery were significantly lower in the off-pump group (P=.001, P=.001, P=.001, and P=.001, respectively). Serum M30 levels were found to be elevated in both groups, returning to baseline at 24 hours. When compared to baseline, the hs-CRP level reached its peak at 24 hours at 13.28±5.32 mg/dL in the on-pump group, and 15.44±4.02 mg/dL in the off-pump group.
  
  
  CONCLUSIONS
  CABG surgery is associated with an increase in inflammatory markers and serum M30 levels, indicating epithelial/endothelial apoptosis in the early period.
authors.affiliation: Department of Cardiovascular Surgery, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Bicer
authors.affiliation: Department of Cardiology, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Tunay
authors.initials: T
authors.lastname: Senturk
authors.affiliation: Department of Cardiovascular Surgery, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Yanar
authors.affiliation: Department of Cardiology, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tutuncu
authors.affiliation: Department of Biochemistry, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Arzu Yilmaztepe
authors.initials: AY
authors.lastname: Oral
authors.affiliation: Department of Biochemistry, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Ulukaya
authors.affiliation: Department of Biochemistry, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Serdar
authors.affiliation: Department of Cardiovascular Surgery, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: Işık Senkaya
authors.initials: IS
authors.lastname: Signak
mesh_terms: D000328:Adult; D017209:Apoptosis / Q000276:immunology; D001026:Coronary Artery Bypass / Q000379:methods*; D003324:Coronary Artery Disease / Q000276:immunology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000276:immunology*; D017382:Reactive Oxygen Species / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D017382:Reactive Oxygen Species