title: Pattern of biopsy proven renal diseases at PNS SHIFA, Karachi: A cross-sectional survey.
abstract: BACKGROUND
  Percutaneous renal biopsy (RB) is an invaluable diagnostic procedure in patients with medical renal diseases.
  
  
  OBJECTIVE
  To determine the pattern of biopsy proven renal disease (BPRD) from a tertiary care naval hospital in Karachi, Pakistan.
  
  
  METHODS
  All the renal biopsies in adult patients (≥18 years) performed at our hospital from 2008 to 2012 were retrospectively reviewed. The biopsies were evaluated by light microscopy and immunofluorescence.
  
  
  RESULTS
  A total 60 cases were analyzed. The mean age was 33.3±12.9 years (range: 18 to 72 years).The male to female ratio was 3:1. The most common indication of renal biopsy was nephrotic syndrome (43.3%), followed by renal failure (26.6%) and non-nephrotic proteinuria (23.3%). Primary glomerulonephritides (PGN) were predominant overall lesions, found in 46 (76.6%) of the total biopsies. Among PGN, the most common lesion was focal segmental glomerulosclerosis (FSGS), followed by membranous glomerulonephritis (MGN), IgA nephropathy (IgAN) and chronic sclerosing glomerulonephritis (CSGN) and a variety of rare lesions. Secondary glomerulonephritides (SGN) were found in only three (5%) cases. There were two cases of amyloidosis and one of lupus nephritis (LN). Tubulointerstitial disease (TID) and vascular disease were rare.
  
  
  CONCLUSIONS
  This study provides information about the epidemiology of BPRD in a large tertiary care naval center in Southern Pakistan.
authors.affiliation: Departments of Nephrology1and Histopathology2, PNS Shifa and SIUT, Karachi, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Sabir
authors.affiliation: Departments of Nephrology1and Histopathology2, PNS Shifa and SIUT, Karachi, Pakistan.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Mubarak
authors.affiliation: Departments of Nephrology1and Histopathology2, PNS Shifa and SIUT, Karachi, Pakistan.
authors.forename: Irfan
authors.initials: I
authors.lastname: Ul-Haq
authors.affiliation: Departments of Nephrology1and Histopathology2, PNS Shifa and SIUT, Karachi, Pakistan.
authors.forename: Aisha
authors.initials: A
authors.lastname: Bibi
keywords: Epidemiology; Glomerulonephritis; Nephropathy; Renal biopsy