title: Prolonged withdrawal following cocaine self-administration increases resistance to punishment in a cocaine binge.
abstract: Drug addiction is characterized by compulsive drug-taking behaviors and a high propensity to relapse following drug cessation. Drug craving and seeking can increase during a period of abstinence, but this phenomenon is not observed in drug-induced reinstatement models. To investigate the effect of withdrawal on cocaine relapse, rats were exposed to extended-access cocaine self-administration and subjected to either 1 or 30 d of withdrawal. When tested during 12 h unlimited access to cocaine (binge), the duration of the withdrawal did not influence cocaine intake. However, using a histamine punishment procedure that greatly suppresses drug-taking behavior, we demonstrate that longer periods of abstinence from cocaine induce a greater persistence in responding for drug in the face of negative consequences.
authors.affiliation: Department of Pharmacology &Toxicology; Research Institute on Addictions, Program of Neuroscience, University at Buffalo, Buffalo New York 14214, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Gancarz-Kausch
authors.affiliation: Department of Pharmacology &Toxicology; Research Institute on Addictions, Program of Neuroscience, University at Buffalo, Buffalo New York 14214, USA.
authors.forename: Danielle N
authors.initials: DN
authors.lastname: Adank
authors.affiliation: Department of Pharmacology &Toxicology; Research Institute on Addictions, Program of Neuroscience, University at Buffalo, Buffalo New York 14214, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Dietz
mesh_terms: D000818:Animals; D032763:Behavior Control; D019970:Cocaine-Related Disorders / Q000523:psychology / Q000628:therapy*; D003216:Conditioning, Operant; D058999:Drug-Seeking Behavior / Q000187:drug effects; D008297:Male; D011678:Punishment; D017207:Rats, Sprague-Dawley; D012008:Recurrence