title: Otilonium bromide as spasmolytic during endoscopic retrograde cholangiopancreatography.
abstract: BACKGROUND
  Endoscopic retrograde cholangiopancreatography (ERCP) is commonly used in both the diagnosis and the treatment of biliary and pancreatic disorders. The aim of this study is to evaluate the effects of OB usage during ERCP on duodenal motility, the tolerability of the procedure (by patients) and the difficulty of the procedure (by the endoscopist).
  
  
  METHODS
  The study was conducted in Konya Training and Research Hospital General Surgery Endoscopy Unit in randomized prospective pattern. The patients were divided into the two groups as spasmolytic and control groups. The procedure was performed under topical anesthesia and sedation.
  
  
  RESULTS
  There were 100 cases included into the study (50 cases in each group). The mean duodenal motility score was found to be 1.9 ± 0.5 in the study group and 3 ± 0.6 in the control group. In the study group, the tolerability of the procedure score by the endoscopist was moderate in 16 % and well/very well in 78 % of the cases. On the other hand, in the control group, the scores were poor in 21 %, moderate in 71 %, and well/very well in 24 % of the cases. In terms of patient satisfaction, in study group 42 % of the cases reported the procedure as moderate and 58 % reported as well/very well. However, in the control group 16 % of the cases reported the procedure as poor, 58 % moderate, and 26 % as well/very well.
  
  
  CONCLUSIONS
  Otilonium bromide is a safe agent with low side effects. It can be used before the ERCP procedure to decrease the duodenal motility. It eases the procedure, moreover, it increases the patients' satisfaction.
authors.affiliation: Department of General Surgery, Konya Training and Research Hospital, Meram Yeniyol, Meram, Konya, Turkey.
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Karahan
authors.forename: Barış
authors.initials: B
authors.lastname: Sevinç
authors.forename: Ahmet
authors.initials: A
authors.lastname: Okuş
authors.forename: Serden
authors.initials: S
authors.lastname: Ay
authors.forename: Nergis
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde; D004386:Duodenum / Q000502:physiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use*; D017060:Patient Satisfaction; D011446:Prospective Studies; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*
chemical_list: D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; C013934:octylonium