title: Mathematical model of sarcoidosis.
abstract: Sarcoidosis is a disease involving abnormal collection of inflammatory cells forming nodules, called granulomas. Such granulomas occur in the lung and the mediastinal lymph nodes, in the heart, and in other vital and nonvital organs. The origin of the disease is unknown, and there are only limited clinical data on lung tissue of patients. No current model of sarcoidosis exists. In this paper we develop a mathematical model on the dynamics of the disease in the lung and use patients' lung tissue data to validate the model. The model is used to explore potential treatments.
authors.affiliation: Mathematical Biosciences Institute, The Ohio State University, Columbus, OH;
authors.forename: Wenrui
authors.initials: W
authors.lastname: Hao
authors.affiliation: Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Medical Center, Columbus, OH; and.
authors.forename: Elliott D
authors.initials: ED
authors.lastname: Crouser
authors.affiliation: Mathematical Biosciences Institute & Department of Mathematics, The Ohio State University, Columbus, OH 43210 afriedman@mbi.osu.edu.
authors.forename: Avner
authors.initials: A
authors.lastname: Friedman
mesh_terms: D006099:Granuloma / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008168:Lung / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D008482:Mediastinum / Q000473:pathology; D018448:Models, Immunological; D017565:Sarcoidosis, Pulmonary / Q000276:immunology* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy
keywords: granuloma; math modeling; sarcoidosis