title: Rebleeding after initial endoscopic hemostasis in peptic ulcer disease.
abstract: Endoscopic hemostasis is the first-line treatment for upper gastrointestinal bleeding (UGIB). Although several factors are known to be risk factors for rebleeding, little is known about the use of antithrombotics. We tried to verify whether the use of antithrombotics affects rebleeding rate after a successful endoscopic hemostasis for peptic ulcer disease (PUD). UGIB patients who underwent successful endoscopic hemostasis were included. Rebleeding was diagnosed when the previously treated lesion bled again within 30 days of the initial episode. Of 522 UGIB patients with PUD, rebleeding occurred in 93 patients (17.8%). The rate of rebleeding was higher with aspirin medication (P=0.006) and after a long endoscopic hemostasis (P<0.001). Of all significant variables, procedure time longer than 13.5 min was related to the rate of rebleeding (OR, 2.899; 95% CI, 1.768-4.754; P<0.001) on the logistic regression analysis. The rate of rebleeding after endoscopic hemostasis for PUD is higher in the patients after a long endoscopic hemostasis. Endoscopic hemostasis longer than 13.5 min is related to rebleeding after a successful endoscopic hemostasis for PUD.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Mi Jin
authors.identifier: 0000-0002-2984-7171
authors.initials: MJ
authors.lastname: Hong
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Sun-Young
authors.identifier: 0000-0003-4146-6686
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Jeong Hwan
authors.identifier: 0000-0002-2503-2688
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: In-Kyung
authors.identifier: 0000-0002-3848-5571
authors.initials: IK
authors.lastname: Sung
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Hyung Seok
authors.identifier: 0000-0003-3141-4858
authors.initials: HS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Chan Sup
authors.identifier: 0000-0002-3300-4417
authors.initials: CS
authors.lastname: Shim
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Choon Jo
authors.identifier: 0000-0001-7569-4076
authors.initials: CJ
authors.lastname: Jin
mesh_terms: D000991:Antithrombins / Q000627:therapeutic use*; D001241:Aspirin / Q000009:adverse effects; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy / Q000601:surgery*; D006470:Hemorrhage / Q000188:drug therapy*; D016558:Hemostasis, Endoscopic / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000601:surgery*; D012008:Recurrence; D041742:Upper Gastrointestinal Tract / Q000473:pathology
chemical_list: D000991:Antithrombins; D001241:Aspirin
keywords: Endoscopic; Hemostasis; Peptic Ulcer; Rebleeding; Upper Gastrointestinal Bleeding