title: MicroRNAs in Tfh cells: micromanaging inflammaging.
abstract: MicroRNA (miR)-146a-deficient mice develop low-grade, chronic, and systemic inflammation, similar to inflammaging. Hu et al. (2014) demonstrate that the lack of miR-155 prevents the accumulation of Tfh cells and inflammaging in miR-146a-deficient mice. They identify Fosl2 as a functionally important target of miR-155 in Tfh cells.
authors.affiliation: The Laboratory of Molecular Immunomodulation, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Department of Medicine, Southern Clinical School, Monash University, Clayton, Australia. Electronic address: di.yu@monash.edu.
authors.forename: Di
authors.initials: D
authors.lastname: Yu
mesh_terms: D000818:Animals; D018858:Germinal Center / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*; D035683:MicroRNAs / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
chemical_list: D035683:MicroRNAs; C534190:Mirn146 microRNA, mouse; C532623:Mirn155 microRNA, mouse