title: Concise review: different mesenchymal stromal/stem cell populations reside in the adult kidney.
abstract: During fetal life, mesenchymal stromal/stem cells (MSCs) surround glomeruli and tubules and contribute to the development of the renal interstitium by secretion of growth factors that drive nephron differentiation. In the adult, an MSC-like population has been demonstrated in different compartments of human and murine nephrons. After injury, these cells might provide support for kidney regeneration by recapitulating the role they have in embryonic life. In this short review, we discuss the evidence of an MSC presence within the adult kidney and their potential contribution to the turnover of renal cells and injury repair.
authors.affiliation: Departments of Molecular Biotechnology and Health Science and Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Stefania
authors.initials: S
authors.lastname: Bruno
authors.affiliation: Departments of Molecular Biotechnology and Health Science and Medical Sciences, University of Torino, Torino, Italy.
authors.forename: Giulia
authors.initials: G
authors.lastname: Chiabotto
authors.affiliation: Departments of Molecular Biotechnology and Health Science and Medical Sciences, University of Torino, Torino, Italy giovanni.camussi@unito.it.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000628:therapy; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology / Q000378:metabolism; D000818:Animals; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D051379:Mice; D009399:Nephrons / Q000166:cytology* / Q000196:embryology / Q000378:metabolism*
keywords: Glomeruli; Kidney; Stem cells; Tissue resident mesenchymal stem cells