title: Is there any impact of HLA-DPB1 disparity in 10/10 HLA-matched unrelated hematopoietic SCT? Results of a French multicentric retrospective study.
abstract: We retrospectively analyzed the impact of HLA-DPB1 mismatches in a large cohort of 1342 French patients who underwent 10/10 HLA-matched unrelated HSCT. A significant impact of HLA-DPB1 allelic mismatches (2 vs 0) was observed in severe acute GVHD (aGVHDIII-IV) (risk ratio (RR)=1.73, confidence interval (CI) 95% 1.09-2.73, P=0.019) without impact on OS, TRM, relapse and chronic GVHD (cGVHD). According to the T-cell epitope 3 (TCE3)/TCE4 HLA-DPB1 disparity algorithm, 37.6% and 58.4% pairs had nonpermissive HLA-DPB1, respectively. TCE3 and TCE4 disparities had no statistical impact on OS, TRM, relapse, aGVHD and cGVHD. When TCE3/TCE4 disparities were analyzed in the graft-vs-host or host-vs-graft (HVG) direction, only a significant impact of TCE4 nonpermissive disparities in the HVG direction was observed on relapse (RR=1.34, CI 95% 1.00-1.80, P=0.048). In conclusion, this French retrospective study shows an adverse prognosis of HLA-DPB1 mismatches (2 vs 0) on severe aGVHD and of nonpermissive TCE4 HVG disparities on relapse after HLA-matched 10/10 unrelated HSCT.
authors.affiliation: 1] HLA Laboratory, EFS Nantes, Nantes, France [2] EA4271 EFS Nantes, Nantes, France [3] Labex Transplantex, Université Strasbourg, Strasbourg, France.
authors.forename: K
authors.initials: K
authors.lastname: Gagne
authors.affiliation: 1] Labex Transplantex, Université Strasbourg, Strasbourg, France [2] HLA Laboratory, Inserm UMR940, AP-HP Paris Saint Louis.
authors.forename: P
authors.initials: P
authors.lastname: Loiseau
authors.affiliation: HLA Laboratory, EFS Lyon, Lyon, France.
authors.forename: V
authors.initials: V
authors.lastname: Dubois
authors.affiliation: HLA Laboratory, CHU Lille, Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Dufossé
authors.affiliation: HLA Laboratory, CHU Nancy, Nancy, France.
authors.forename: P
authors.initials: P
authors.lastname: Perrier
authors.affiliation: HLA Laboratory, EFS Besançon, Besancon, France.
authors.forename: A
authors.initials: A
authors.lastname: Dormoy
authors.affiliation: HLA Laboratory, EFS Poitiers, Poitiers, France.
authors.forename: I
authors.initials: I
authors.lastname: Jollet
authors.affiliation: HLA Laboratory, EFS Rennes, Rennes, France.
authors.forename: V
authors.initials: V
authors.lastname: Renac
authors.affiliation: HLA Laboratory, EFS Grenoble, Grenoble, France.
authors.forename: D
authors.initials: D
authors.lastname: Masson
authors.affiliation: HLA Laboratory, UMR 7268 Université Aix-Marseille, EFS Marseille, Marseille, France.
authors.forename: C
authors.initials: C
authors.lastname: Picard
authors.affiliation: HLA Laboratory, EFS Bordeaux, Bordeaux, France.
authors.forename: X
authors.initials: X
authors.lastname: Lafarge
authors.affiliation: HLA Laboratory, EFS Strasbourg, Strasbourg, France.
authors.forename: D
authors.initials: D
authors.lastname: Hanau
authors.affiliation: HLA Laboratory, EFS Clermont-Ferrand, Clermont-Ferrand, France.
authors.forename: F
authors.initials: F
authors.lastname: Quainon
authors.affiliation: HLA Laboratory, AP-HP Paris Créteil, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Delbos
authors.affiliation: HLA Laboratory, EFS Angers, Angers, France.
authors.forename: B
authors.initials: B
authors.lastname: Coeffic
authors.affiliation: HLA Laboratory, EFS Saint-Etienne, Saint-Etienne, France.
authors.forename: Léna
authors.initials: L
authors.lastname: Absi
authors.affiliation: 1] HLA Laboratory, CHU Montpellier, Montpellier, France [2] Société Francophone d'Histocompatibilité et d'Immunogénétique (SFHI), Paris, France.
authors.forename: J-F
authors.initials: JF
authors.lastname: Eliaou
authors.affiliation: HLA Laboratory, CHU Brest, Brest, France.
authors.forename: V
authors.initials: V
authors.lastname: Moalic
authors.affiliation: HLA Laboratory, CHU Toulouse, Toulouse, France.
authors.forename: M
authors.initials: M
authors.lastname: Fort
authors.affiliation: HLA Laboratory, CHU Nice, Nice, France.
authors.forename: M
authors.initials: M
authors.lastname: de Matteis
authors.affiliation: HLA Laboratory, AP-HP Paris Pitié Salpetrière, Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Theodorou
authors.affiliation: HLA Laboratory, EFS Rouen, Rouen, France.
authors.forename: F
authors.initials: F
authors.lastname: Hau
authors.affiliation: HLA Laboratory, EFS Caen, Caen, France.
authors.forename: A
authors.initials: A
authors.lastname: Batho
authors.affiliation: HLA Laboratory, AP-HP Paris Robert Debré, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: Pedron
authors.affiliation: HLA Laboratory, AP-HP Paris Necker, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Caillat-Zucman
authors.affiliation: Registre France Greffe de Moelle (RFGM), Saint Denis La Plaine, France.
authors.forename: E
authors.initials: E
authors.lastname: Marry
authors.affiliation: Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), Hematology Department, University Hospital, Lille, France.
authors.forename: N
authors.initials: N
authors.lastname: Raus
authors.affiliation: Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC), Hematology Department, University Hospital, Lille, France.
authors.forename: I
authors.initials: I
authors.lastname: Yakoub-Agha
authors.affiliation: 1] HLA Laboratory, EFS Nantes, Nantes, France [2] Labex Transplantex, Université Strasbourg, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Cesbron
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D064591:Allografts; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006086:Graft vs Host Disease / Q000401:mortality / Q000517:prevention & control; D059868:HLA-DP beta-Chains; D019337:Hematologic Neoplasms / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006789:Host vs Graft Reaction; D006801:Humans; D008297:Male; D008875:Middle Aged; D061349:Unrelated Donors
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen