title: Burden of malaria in early pregnancy: a neglected problem?
abstract: According to the current World Health Organization guidelines, the drug prevention of malaria during pregnancy does not adequately cover the first trimester of gestation in high-transmission areas. Although the pathophysiological mechanisms of early infections are not completely understood yet, a review of the most recent studies on the topic suggests that their consequences are serious in terms of maternal anemia and low birth weight. Consequently, there is a need to focus on the awareness of women in a period hard to access, to develop safe drugs to be used in the first trimester, and to consider preconceptional interventions in teenage girls, such as a new malaria vaccine to be used in pregnancy.
authors.affiliation: Research Institute for Development Université Paris Descartes, Sorbonne Paris Cité, UMR 216, Paris, France.
authors.forename: Bich-Tram
authors.initials: BT
authors.lastname: Huynh
authors.affiliation: Research Institute for Development Université Paris Descartes, Sorbonne Paris Cité, UMR 216, Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Cottrell
authors.affiliation: Research Institute for Development Université Paris Descartes, Sorbonne Paris Cité, UMR 216, Paris, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Cot
authors.affiliation: Research Institute for Development Université Paris Descartes, Sorbonne Paris Cité, UMR 216, Paris, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Briand
mesh_terms: D000293:Adolescent; D000740:Anemia; D000962:Antimalarials / Q000627:therapeutic use; D017281:Cost of Illness; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008288:Malaria / Q000503:physiopathology / Q000517:prevention & control; D017780:Malaria Vaccines; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000503:physiopathology / Q000517:prevention & control; D011261:Pregnancy Trimester, First
chemical_list: D000962:Antimalarials; D017780:Malaria Vaccines
keywords: Africa; malaria; pregnancy complication; prevention; time factors