title: Relationship between serum uric acid and serum oxidative stress markers in the Japanese general population.
abstract: BACKGROUND
  Increased production of reactive oxygen species is a condition that is associated with, and plays a role in the progression of, various disorders such as hypertension, atherosclerosis, and diabetes.
  
  
  OBJECTIVE
  To assess in vivo oxidative stress levels and antioxidant potential and to analyze the relationship with serum uric acid (UA) levels.
  
  
  RESULTS
  Oxidative stress levels (derivatives of reactive oxygen metabolites, d-ROMs) and antioxidant potential (biological antioxidant potential, BAP) were measured in individuals who underwent a general health screening test, and data were analyzed from 8,025 individuals (2,953 women and 5,072 men) who were free from UA-lowering medication. Higher serum UA levels were associated with increased levels of d-ROMs in both genders, and this trend was more prominent in women. In addition, higher UA levels were also associated with higher BAP in both genders, although the dose dependence was not apparent in men. These associations remained statistically significant after adjusting for age, blood pressure, renal function, albuminuria, C-reactive protein, and insulin resistance index.
  
  
  CONCLUSIONS
  In individuals who underwent general health screening, serum UA levels were positively associated with both d-ROMs and BAP levels. Whether lowering of UA by lifestyle modification or by medication alters d-ROM/BAP levels awaits further investigations. .
authors.affiliation: Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital, Tokyo, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishizaka
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Akiko
authors.initials: A
authors.lastname: Toda
authors.forename: Mizuki
authors.initials: M
authors.lastname: Tani
authors.forename: Nobukazu
authors.initials: N
authors.lastname: Ishizaka
mesh_terms: D044466:Asian People; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid