title: Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight.
abstract: To test the hypothesis that mildly elevated triglyceride levels are associated with the increase of homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) indices in healthy children and adolescents with normal weight, we conducted a cross-sectional population study. Based on fasting triglyceride levels, participants were allocated into groups with and without triglyceride levels ≥1.2 mmol/L. Normal weight was defined by body mass index between the 15th and 85th percentiles, for age and gender. Insulin resistance and insulin secretion were estimated using HOMA-IR and HOMA-β indices. A total of 1660 children and adolescents were enrolled, of them 327 (19.7%) with mildly elevated triglycerides. The multivariate linear regression analysis showed that mildly elevated triglyceride levels in children were associated with HOMA-IR (β = 0.214, p < 0.001), HOMA-β (β = 0.139, p = 0.001), systolic (β = 0.094, p = 0.01), and diastolic blood pressure (β = 0.102, p = 0.007), whereas in adolescents, HOMA-IR (β = 0.267, p < 0.001) and HOMA-β (β = 0.154, p < 0.001), but not systolic (β = 0.029, p = 0.38) and diastolic blood pressure (β = 0.015, p = 0.642), showed association with mildly elevated triglycerides.
  
  
  CONCLUSIONS
  Mildly elevated triglyceride levels are associated with increased HOMA-IR and HOMA-β indices in healthy children and adolescents with normal weight.
authors.affiliation: Biomedical Research Unit of the Mexican Social Security Institute, Siqueiros 225 esq/Castañeda, 34000, Durango, DGO, Mexico, luis_simental81@hotmail.com.
authors.forename: Luis E
authors.initials: LE
authors.lastname: Simental-Mendía
authors.forename: Argelia
authors.initials: A
authors.lastname: Castañeda-Chacón
authors.forename: Martha
authors.initials: M
authors.lastname: Rodriguez-Morán
authors.forename: Celia
authors.initials: C
authors.lastname: Aradillas-García
authors.forename: Fernando
authors.initials: F
authors.lastname: Guerrero-Romero
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D016014:Linear Models; D008297:Male; D011627:Puberty / Q000378:metabolism; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides