title: [Updates on Lifestyle-Related Diseases and Bone Metabolism. The relationship between incretin and bone metabolism].
abstract: There are two kinds of incretin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) . GIP directly affects osteoblasts and osteoclasts, resulting in increasing bone mass by enhancing bone formation and suppressing bone resorption. On the other hand, GLP-1 does not affect bone directly. GLP-1 is reported to stimulate calcitonin secretion in thyroid gland and then indirectly increase bone mass. Dipeptidyl peptidase-4 inhibitors, which activate the function of incretin, may decrease the risk of osteoporotic fractures. In addition, it has been shown that osteoblast-derived osteocalcin stimulates GLP-1 secretion. Therefore, there may be an interaction between bone and digestive tract.
authors.affiliation: Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Kanazawa
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism; D006801:Humans; D054795:Incretins / Q000378:metabolism*; D008019:Life Style
chemical_list: D054795:Incretins; D052216:Glucagon-Like Peptide 1