title: Synthesis, antibacterial, antiurease, and antioxidant activities of some new 1,2,4-triazole schiff base and amine derivatives.
abstract: The acylhydrazone compound named ethyl N'-furan-2-carbonylbenzohydrazonate was synthesized by the condensation of ethyl benzimidate hydrochloride with furan-2-carbohydrazide. The treatment of the acylhydrazone with hydrazine hydrate afforded 4-amino-3-furan-2-yl-5-phenyl-1,2,4-triazole. The usage of this compound with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3-furan-2-yl-5-phenyl-1,2,4-triazoles. The obtained products were identified by FT-IR, (1)H-NMR, (13)C-NMR. A series of compounds were evaluated for their antibacterial, antiurease, and antioxidant activities. The results showed that the synthesized new compounds had effective antiurease and antioxidant activities.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Giresun University, 28049, Giresun, Turkey, baharsokmen@yahoo.com.
authors.forename: Bahar Bilgin
authors.initials: BB
authors.lastname: Sokmen
authors.forename: Nurhan
authors.initials: N
authors.lastname: Gumrukcuoglu
authors.forename: Serpil
authors.initials: S
authors.lastname: Ugras
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sahin
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Sagkal
authors.forename: Halil Ibrahim
authors.initials: HI
authors.lastname: Ugras
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000037:antagonists & inhibitors; D057075:Enzyme Assays; D005663:Furans / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010084:Oxidation-Reduction; D010851:Picrates / Q000037:antagonists & inhibitors; D012545:Schiff Bases / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005663:Furans; D006835:Hydrazones; D010851:Picrates; D012545:Schiff Bases; D014230:Triazoles; C004931:1,1-diphenyl-2-picrylhydrazyl