title: The cell biology of planar cell polarity.
abstract: Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contribute to asymmetric PCP protein localization. Additionally, the functions of gradients and mechanical forces as global cues that bias PCP orientation are beginning to be elucidated. Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level.
authors.affiliation: Department of Molecular Biology, Princeton University, Princeton, NJ 08544 danelle@princeton.edu.
authors.forename: Danelle
authors.initials: D
authors.lastname: Devenport
mesh_terms: D000818:Animals; D019521:Body Patterning; D002450:Cell Communication; D016764:Cell Polarity; D003463:Cues; D004330:Drosophila / Q000166:cytology* / Q000196:embryology; D008954:Models, Biological; D015398:Signal Transduction