title: Controlled circumferential renal sympathetic denervation with preservation of the renal arterial wall using intraluminal ultrasound: a next-generation approach for treating sympathetic overactivity.
abstract: OBJECTIVE
  The Paradise Ultrasound Renal Denervation System is a next-generation catheter-based device which was used to investigate whether the target ablation area can be controlled by changing ultrasound energy and duration to optimise nerve injury while preventing damage to the arterial wall.
  
  
  RESULTS
  Five ultrasound doses were tested in a thermal gel model. Catheter-based ultrasound denervation was performed in 15 swine (29 renal arteries) to evaluate five different doses in vivo, and animals were euthanised at seven days for histopathologic assessment. In the gel model, the peak temperature was highest in the low power-long duration (LP-LD) dose, followed by the mid-low power-mid duration (MLP-MD) dose and the mid-high power-short duration (MHP-SD) dose, and lowest in the mid power-short duration (MP-SD) dose and the high power-ultra short duration (HP-USD) dose. In the animal study, total ablation area was significantly greater in the LP-LD group, followed by the MLP-MD group, and it was least in the HP-USD, MP-SD and MHP-SD groups (p=0.02). Maximum distance was significantly greater in the LP-LD group, followed by the MLP-MD group, the MHP-SD group, and the HP-USD group, and shortest in the MP-SD group (p=0.007). The short spare distance was not different among the five groups (p=0.38). Renal artery damage was minimal, while preserving significant nerve damage in all groups.
  
  
  CONCLUSIONS
  The Paradise Ultrasound Renal Denervation System is a controllable system where total ablation area and depth of ablation can be optimised by changing ultrasound power and duration while sparing renal arterial tissue damage but allowing sufficient peri-arterial nerve damage.
authors.affiliation: CVPath Institute Inc., Gaithersburg, MD, USA.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakakura
authors.forename: Austin
authors.initials: A
authors.lastname: Roth
authors.forename: Elena
authors.initials: E
authors.lastname: Ladich
authors.forename: Kai
authors.initials: K
authors.lastname: Shen
authors.forename: Leslie
authors.initials: L
authors.lastname: Coleman
authors.forename: Michael
authors.initials: M
authors.lastname: Joner
authors.forename: Renu
authors.initials: R
authors.lastname: Virmani
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation* / Q000379:methods; D005782:Gels; D006973:Hypertension / Q000601:surgery*; D066298:In Vitro Techniques; D008953:Models, Anatomic; D059745:Piezosurgery / Q000295:instrumentation* / Q000379:methods; D012077:Renal Artery / Q000294:innervation / Q000473:pathology / Q000601:surgery*; D013552:Swine; D013562:Sympathectomy / Q000295:instrumentation* / Q000379:methods
chemical_list: D005782:Gels