title: Ubiquitin-mediated NFκB degradation pathway.
abstract: The nuclear factor κB (NFκB) transcription factor plays critical roles in inflammation and immunity. The dysregulation of NFκB is associated with inflammatory and autoimmune diseases and cancer. NFκB activation is negatively regulated by the ubiquitin-dependent proteasomal degradation pathway. In the present review, we discuss recent advances in our understanding of how ubiquitin ligases regulate the NFκB degradation pathway.
authors.forename: Huimin
authors.initials: H
authors.lastname: Xu
authors.forename: Mengli
authors.initials: M
authors.lastname: You
authors.forename: Haifeng
authors.initials: H
authors.lastname: Shi
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Hou
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D016328:NF-kappa B / Q000235:genetics* / Q000276:immunology; D009369:Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D046988:Proteasome Endopeptidase Complex / Q000276:immunology / Q000378:metabolism; D055550:Protein Stability; D059748:Proteolysis; D015398:Signal Transduction; D025801:Ubiquitin / Q000235:genetics* / Q000276:immunology; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000276:immunology; D050880:p300-CBP Transcription Factors / Q000235:genetics / Q000276:immunology; D000099224:p300-CBP-Associated Factor
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D016328:NF-kappa B; D046988:Proteasome Endopeptidase Complex; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C480519:COMMD1 protein, human