title: Posterior polymorphous corneal dystrophy concomitant to large colloid drusen.
abstract: OBJECTIVE
  To describe the previously unreported concomitance of 2 uncommon ocular conditions: posterior polymorphous corneal dystrophy (PPCD) and large colloid drusen (LCD).
  
  
  METHODS
  A 45-year-old woman underwent a complete ophthalmologic examination with slit-lamp biomicroscopy and blue fundus autofluorescence with spectral-domain optical coherence tomography, as well as complete systemic examination and renal function investigation.
  
  
  RESULTS
  On slit-lamp biomicroscopy, a corneal lesion located at Descemet membrane was observed in the right eye. The clinical features of deep posterior stromal-endothelial linear bands with vesicles and irregular opacities of posterior corneal surface were consistent with the diagnosis of PPCD. Fundus biomicroscopy and blue fundus autofluorescence showed LCD.
  
  
  CONCLUSIONS
  We report the unusual coexistence of PPCD and LCD in a young, healthy subject. Posterior polymorphous corneal dystrophy and LCD share morphologic similarities and dysfunctions of collagen architecture in the basement membrane layer, which suggests a possible common pathogenic pathway.
authors.affiliation: Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milan - Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Del Turco
authors.forename: Luisa
authors.initials: L
authors.lastname: Pierro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Querques
authors.forename: Marco
authors.initials: M
authors.lastname: Gagliardi
authors.forename: Federico
authors.initials: F
authors.lastname: Corvi
authors.forename: Maria Pia
authors.initials: MP
authors.lastname: Manitto
authors.forename: Francesco M
authors.initials: FM
authors.lastname: Bandello
mesh_terms: D003102:Colloids; D003317:Corneal Dystrophies, Hereditary / Q000150:complications* / Q000175:diagnosis; D003886:Descemet Membrane / Q000473:pathology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008875:Middle Aged; D015593:Retinal Drusen / Q000150:complications* / Q000175:diagnosis; D066167:Slit Lamp; D041623:Tomography, Optical Coherence / Q000379:methods
chemical_list: D003102:Colloids