title: Exercise, neurotrophins, and axon regeneration in the PNS.
abstract: Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.
authors.affiliation: Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and medae@emory.edu.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: English
authors.affiliation: Department of Psychology, College of Charleston, Charleston, South Carolina.
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Wilhelm
authors.affiliation: Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia; and.
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Ward
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism / Q000473:pathology; D004599:Electric Stimulation Therapy; D005081:Exercise Therapy; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D009414:Nerve Growth Factors / Q000378:metabolism*; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D010525:Peripheral Nerves / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D020127:Recovery of Function; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D012739:Gonadal Steroid Hormones; D009414:Nerve Growth Factors