title: Atheroprotective effects of (poly)phenols: a focus on cell cholesterol metabolism.
abstract: Collated observations from several epidemiological studies have demonstrated that dietary intake of (poly)phenols from nuts, coffee, cocoa, grapes, and berries may protect against the development of atherosclerosis. Whereas this beneficial activity has previously been linked mainly to antioxidant or anti-inflammatory properties, recently emerging data suggest mechanisms by which (poly)phenolic substances can modulate cellular lipid metabolism, thereby mitigating atherosclerotic plaque formation. In this review, both experimental studies and clinical trials investigating the atheroprotective effects of the most relevant dietary (poly)phenols are critically discussed.
authors.affiliation: Department of Pharmacy, University of Parma, Viale delle Scienze 27/A, 43124 Parma, Italy.
authors.forename: Ilaria
authors.initials: I
authors.lastname: Zanotti
authors.forename: Margherita
authors.initials: M
authors.lastname: Dall'Asta
authors.forename: Pedro
authors.initials: P
authors.lastname: Mena
authors.forename: Laura
authors.initials: L
authors.lastname: Mele
authors.forename: Renato
authors.initials: R
authors.lastname: Bruni
authors.forename: Sumantra
authors.initials: S
authors.lastname: Ray
authors.forename: Daniele
authors.initials: D
authors.lastname: Del Rio
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use; D050197:Atherosclerosis / Q000378:metabolism / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism*; D003069:Coffee / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D055951:Functional Food / Q000032:analysis*; D006801:Humans; D008954:Models, Biological; D018673:Nutrition Policy; D009754:Nuts / Q000737:chemistry; D064209:Phytochemicals / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D059808:Polyphenols / Q000032:analysis / Q000378:metabolism / Q000627:therapeutic use*; D027843:Vitis / Q000737:chemistry
chemical_list: D000924:Anticholesteremic Agents; D003069:Coffee; D064209:Phytochemicals; D059808:Polyphenols; D002784:Cholesterol