title: [Updates on Lifestyle-Related Diseases and Bone Metabolism. The metabolic syndrome and bone metabolism].
abstract: The metabolic syndrome is featured by the combination of obesity induced by visceral fat accumulation, dyslipidemia, hyperglycemia, and hypertension. It is well documented that obesity and body weight increase are positively linked to increased bone mineral density (BMD) and reduced fracture risk of weight-bearing bones through mechanical stress. On the other hand, inflammatory cytokines secreted from visceral fat and advanced glycation products induced by hyperglycemia tend to reduce BMD and to increase fracture risk in contrast to obesity. Thus, BMD and fracture risk in patients with the metabolic syndrome may be determined by the balance between the beneficial effect of obesity and detrimental ones of inflammatory cytokines and hyperglycemia on bone.
authors.affiliation: Internal Medicine 1, Shimane University Faculty of Medicine, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism*; D050723:Fractures, Bone / Q000209:etiology; D006801:Humans; D008019:Life Style; D024821:Metabolic Syndrome / Q000150:complications*; D012307:Risk Factors