title: ADReCS: an ontology database for aiding standardization and hierarchical classification of adverse drug reaction terms.
abstract: Adverse drug reactions (ADRs) are noxious and unexpected effects during normal drug therapy. They have caused significant clinical burden and been responsible for a large portion of new drug development failure. Molecular understanding and in silico evaluation of drug (or candidate) safety in laboratory is thus so desired, and unfortunately has been largely hindered by misuse of ADR terms. The growing impact of bioinformatics and systems biology in toxicological research also requires a specialized ADR term system that works beyond a simple glossary. Adverse Drug Reaction Classification System (ADReCS; http://bioinf.xmu.edu.cn/ADReCS) is a comprehensive ADR ontology database that provides not only ADR standardization but also hierarchical classification of ADR terms. The ADR terms were pre-assigned with unique digital IDs and at the same time were well organized into a four-level ADR hierarchy tree for building an ADR-ADR relation. Currently, the database covers 6544 standard ADR terms and 34,796 synonyms. It also incorporates information of 1355 single active ingredient drugs and 134,022 drug-ADR pairs. In summary, ADReCS offers an opportunity for direct computation on ADR terms and also provides clues to mining common features underlying ADRs.
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Mei-Chun
authors.initials: MC
authors.lastname: Cai
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Xu
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P.R. China.
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Wen
authors.initials: W
authors.lastname: Pan
authors.affiliation: Xiamen Huli Center For Disease Control and Prevention, Xiamen, Fujian 361000, P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ji
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Yin-Bo
authors.initials: YB
authors.lastname: Li
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Jin
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China.
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, P.R. China The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, P.R. China appo@xmu.edu.cn.
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Ji
mesh_terms: D064229:Biological Ontologies; D002965:Classification / Q000379:methods; D016208:Databases, Factual; D064420:Drug-Related Side Effects and Adverse Reactions; D020407:Internet; D009626:Terminology as Topic