title: The RED light is on! New tools for monitoring Ca2+ dynamics in the endoplasmic reticulum and mitochondria.
abstract: In this issue of the Biochemical Journal, Wu et al. describe the characterization of new low-affinity Ca2+ indicators for monitoring Ca2+ levels in both the ER (endoplasmic reticulum) and mitochondria. In contrast with other ER Ca2+ sensors, these indicators emit in the red part of the spectrum, allowing for their use in combination with GFP-based probes and expanding the genetically encoded tool kit for the measurement of Ca2+ inside organelles.
authors.affiliation: *Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
authors.forename: Saverio
authors.initials: S
authors.lastname: Marchi
authors.affiliation: *Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis*; D004721:Endoplasmic Reticulum / Q000737:chemistry*; D006801:Humans; D008164:Luminescent Proteins / Q000032:analysis* / Q000235:genetics*; D008928:Mitochondria / Q000737:chemistry*; D015202:Protein Engineering / Q000379:methods*; D000097573:Red Fluorescent Protein
chemical_list: D002118:Calcium; D008164:Luminescent Proteins; D000097573:Red Fluorescent Protein