title: Pd-catalyzed C-H carbonylation of (hetero)arenes with formates and intramolecular dehydrogenative coupling: a shortcut to indolo[3,2-c]coumarins.
abstract: An efficient protocol for the synthesis of (hetero)aryl carboxylic esters has been achieved by Pd-catalyzed C-H carbonylation of (hetero)arenes with aryl formates. A relatively wide range of functional groups can be tolerated in this transformation, and the corresponding esters are obtained in good yields. On this basis, an intramolecular oxidative C-H/C-H coupling has been developed to prepare indolo[3,2-c]coumarins.
authors.affiliation: Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University , 29 Wangjiang Road, Chengdu 610064, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Jingbo
authors.initials: J
authors.lastname: Lan
authors.forename: Siyuan
authors.initials: S
authors.lastname: Guo
authors.forename: Jingsong
authors.initials: J
authors.lastname: You
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D004952:Esters; D005561:Formates / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D058451:Oxidative Coupling; D010165:Palladium / Q000737:chemistry*
chemical_list: D003374:Coumarins; D004952:Esters; D005561:Formates; D006576:Heterocyclic Compounds, 4 or More Rings; D007211:Indoles; D010165:Palladium