title: An enolate-mediated organocatalytic azide-ketone [3+2]-cycloaddition reaction: regioselective high-yielding synthesis of fully decorated 1,2,3-triazoles.
abstract: An enolate-mediated organocatalytic azide-ketone [3+2]-cycloaddition (OrgAKC) reaction of a variety of enolizable arylacetones and deoxybenzoins with aryl azides was developed for the synthesis of fully decorated 1,4-diaryl-5-methyl(alkyl)-1,2,3-triazoles in excellent yields with high regioselectivity at 25 °C for 0.5-6 h. This reaction has an excellent outcome with reference to reaction rate, yield, regioselectivity, operation simplicity, and availability of substrates and catalyst. This reaction has advantages over the previously known metal-mediated reactions.
authors.affiliation: Catalysis Laboratory, School of Chemistry, University of Hyderabad, Hyderabad-500 046 (India), Fax: (+91) 40-23012460.
authors.forename: Adluri B
authors.initials: AB
authors.lastname: Shashank
authors.forename: S
authors.initials: S
authors.lastname: Karthik
authors.forename: R
authors.initials: R
authors.lastname: Madhavachary
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
keywords: azides; click reaction; ketones; organocatalysis; triazoles