title: Rhodium(III)-Catalyzed C-H Activation Mediated Synthesis of Isoquinolones from Amides and Cyclopropenes.
abstract: We have developed a synthesis of 4-substituted isoquinolones from the Rh(III)-catalyzed, C-H activation mediated, coupling ofO-pivaloyl benzhydroxamic acids and 3,3-disubstituted cyclopropenes. Experiments suggest the formation of a [4.1.0] bicyclic-system, which can open under acidic conditions to generate the desired isoquinolone.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80526, USA.
authors.forename: Todd K
authors.initials: TK
authors.lastname: Hyster
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, CO 80526, USA.
authors.forename: Tomislav
authors.initials: T
authors.lastname: Rovis
keywords: C–H activation; cyclopropene; donor-acceptor cyclopropane; heterocycles; isoquinolone