title: Genetics pathway-based imaging approaches in Chinese Han population with Alzheimer's disease risk.
abstract: The tau hypothesis has been raised with regard to the pathophysiology of Alzheimer's disease (AD). Mild cognitive impairment (MCI) is associated with a high risk for developing AD. However, no study has directly examined the brain topological alterations based on combined effects of tau protein pathway genes in MCI population. Forty-three patients with MCI and 30 healthy controls underwent resting-state functional magnetic resonance imaging (fMRI) in Chinese Han, and a tau protein pathway-based imaging approaches (7 candidate genes: 17 SNPs) were used to investigate changes in the topological organisation of brain activation associated with MCI. Impaired regional activation is related to tau protein pathway genes (5/7 candidate genes) in patients with MCI and likely in topologically convergent and divergent functional alterations patterns associated with genes, and combined effects of tau protein pathway genes disrupt the topological architecture of cortico-cerebellar loops. The associations between the loops and behaviours further suggest that tau protein pathway genes do play a significant role in non-episodic memory impairment. Tau pathway-based imaging approaches might strengthen the credibility in imaging genetic associations and generate pathway frameworks that might provide powerful new insights into the neural mechanisms that underlie MCI.
authors.affiliation: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing, 210009, China. baifeng515@126.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
authors.affiliation: Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, 310015, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liao
authors.affiliation: Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Chunxian
authors.initials: C
authors.lastname: Yue
authors.affiliation: Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Mengjia
authors.initials: M
authors.lastname: Pu
authors.affiliation: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing, 210009, China.
authors.forename: Yongmei
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.affiliation: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing, 210009, China.
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.affiliation: Medical School of Southeast University, Nanjing, 210009, China.
authors.forename: Leiyu
authors.initials: L
authors.lastname: Geng
authors.affiliation: Department of Neurology, Affiliated ZhongDa Hospital of Southeast University, The Institute of Neuropsychiatry of Southeast University, Nanjing, 210009, China. janemengzhang@vip.163.com.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002531:Cerebellum / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D002681:China; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D005260:Female; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D012307:Risk Factors; D016875:tau Proteins / Q000235:genetics*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins
keywords: Cortico-cerebellar loops; Gene; Mild cognitive impairment; Resting state; Tau protein pathways; fMRI