title: Supramolecular nanofibers of triamcinolone acetonide for uveitis therapy.
abstract: Supramolecular nanofibers of prodrugs hold advantages for drug release due to their high drug payload, sustained and constant drug release behavior, and stimuli responsiveness. In this study, we report on a supramolecular hydrogel mainly formed by a clinically used drug triamcinolone acetonide (TA). Such a hydrogel could only be prepared via an ester bond hydrolysis process from its prodrug of succinated triamcinolone acetonide (STA). The resulting hydrogel could constantly release TA in the in vitro release experiment. The TA hydrogel possessed an excellent transscleral penetration ability, as evaluated by the in vitro transscleral transport study. The developed TA hydrogel also exhibited a great ocular compatibility in rats, as indicated by the optical coherence tomography (OCT) images, HE observation, and glial fibrillary acidic protein (GFAP) and vimentin immuno-staining assays of the retinas. Our TA hydrogel showed a decreased efficacy to inhibit ocular inflammation in the rat's experiment autoimmune uveitis (EAU) model compared to the commercial TA suspension (Transton), but without causing complications such as high intraocular pressure and cataracts. These promising properties of the hydrogel indicated its great potential for the treatment of eye diseases.
authors.affiliation: Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye hospital, Wenzhou Medical University, 270 Xueyuan Road, Wenzhou 325027, P.R. China. dragonhaochen@163.com.
authors.forename: Xingyi
authors.initials: X
authors.lastname: Li
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Wang
authors.forename: Chengbiao
authors.initials: C
authors.lastname: Yang
authors.forename: Shuai
authors.initials: S
authors.lastname: Shi
authors.forename: Ling
authors.initials: L
authors.lastname: Jin
authors.forename: Zichao
authors.initials: Z
authors.lastname: Luo
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Zhaoliang
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D001692:Biological Transport / Q000187:drug effects; D020100:Hydrogels / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D057139:Nanofibers / Q000737:chemistry*; D051381:Rats; D011917:Rats, Inbred Lew; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014605:Uveitis / Q000188:drug therapy / Q000473:pathology
chemical_list: D020100:Hydrogels; D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide