title: The definition and detection of acute kidney injury.
abstract: The first consensus definition of Acute Kidney Injury (AKI) was published a decade ago. In this mini narrative review we look at the history of the changes in the definition of AKI and consider how it may change again in the near future. The epidemiology of small changes in creatinine and the difficulties with determining baseline creatinine have driven the changes. Recent evidence on urinary output and the application of structural injury biomarkers are likely to change the definition once more.
authors.affiliation: Department of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
authors.forename: John W
authors.initials: JW
authors.lastname: Pickering
authors.affiliation: Department of Nephrology, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia.
authors.forename: Zoltán H
authors.initials: ZH
authors.lastname: Endre
keywords: Acute kidney injury; Cystatin C; Glomerular filtration rate