title: Epidemiology and temporal trends (2000-2012) of inflammatory bowel disease in adult patients in a central region of Spain.
abstract: OBJECTIVE
  A growing incidence of inflammatory bowel disease (IBD) has been reported recently in southern Europe, with records of pediatric cases confirming these tendencies in Spain. Data on adult populations, however, have not been provided for over 10 years and need to be updated.
  
  
  METHODS
  A multicenter retrospective registry of all adult patients with a diagnosis of IBD, including both Crohn's disease (CD) and ulcerative colitis (UC), attending five public hospitals covering a population of 514 368 inhabitants, was assessed.
  
  
  RESULTS
  In 2012, the prevalence of CD and UC in adults was 137.17/100 000 inhabitants (95% confidence interval 114-160) and 99.84/100 000 inhabitants (95% confidence interval 79-119), respectively. The mean incidence rate during the period 2000-2012 of CD and UC was 8.9 and 5.6/100 000 inhabitants per year, respectively. Most of our patients (75.55%) had been diagnosed during the last 13 years. CD affected both sexes equally; a trend toward a progressive increase in the age at diagnosis, ileal location, and inflammatory behavior was documented for CD patients. In contrast, UC affected male patients with a higher frequency (57.8%; P=0.015), specifically those older than 40 years of age. Age at UC onset tended to increase progressively from 2000 to 2012 (P<0.001), but the extension on the disease remained unchanged.
  
  
  CONCLUSIONS
  IBD is a highly prevalent disorder in our region, reaching the incidence of CD similar to the figures provided for Northern Europe. Changes in IBD localization, behavior, and age at diagnosis were documented during the period 2000-2012.
authors.affiliation: aDepartment of Gastroenterology, Hospital General de Tomelloso, Tomelloso bDepartment of Gastroenterology, Hospital Virgen de Altagracia, Manzanares cDepartment of Gastroenterology dResearch Support Unit, Hospital General La Mancha Centro, Alcázar de San Juan eIBD Unit, Department of Gastroenterology, Hospital General Universitario de Ciudad Real, Ciudad Real fDepartment of Gastroenterology, Hospital Santa Bárbara, Puertollano, Spain.
authors.forename: Alfredo J
authors.initials: AJ
authors.lastname: Lucendo
authors.forename: Daniel
authors.initials: D
authors.lastname: Hervías
authors.forename: Óscar
authors.initials: Ó
authors.lastname: Roncero
authors.forename: Rufo
authors.initials: R
authors.lastname: Lorente
authors.forename: Abdelmouneim
authors.initials: A
authors.lastname: Bouhmidi
authors.forename: Teresa
authors.initials: T
authors.lastname: Angueira
authors.forename: Cristina
authors.initials: C
authors.lastname: Verdejo
authors.forename: Irina
authors.initials: I
authors.lastname: Salueña
authors.forename: Sonia
authors.initials: S
authors.lastname: González-Castillo
authors.forename: Ángel
authors.initials: Á
authors.lastname: Arias
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006779:Hospitals, Public; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors; D055815:Young Adult