title: Neurotensin-like peptides as potential antipsychotics: modulation of the serotonin system.
abstract: Neurotensin-like peptides acting as functional antagonists of serotonin receptors were revealed in the head-shaking test on mice. The neurotensin-like peptides block the serotonin-induced platelet aggregation in humans. Radioligand binding assay showed that neurotensin-like peptides modulate specifi c binding of 5НТ2 serotonin receptor antagonist ketanserin, but have no effect on binding of ligands of 5HT2c receptor mesulergine and 5HT1а receptors NAN-190. Similar effects of neurotensin-like peptides in the experiments in vivo and in vitro suggest that the mechanisms of the detected antipsychotic effect of the peptides can be mediated by serotonin receptors.
authors.affiliation: Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia, nat-kost@yandex.ru.
authors.forename: N V
authors.initials: NV
authors.lastname: Kost
authors.forename: V K
authors.initials: VK
authors.lastname: Meshavkin
authors.forename: E Yu
authors.initials: EY
authors.lastname: Khashaba
authors.forename: O Yu
authors.initials: OY
authors.lastname: Sokolov
authors.forename: M E
authors.initials: ME
authors.lastname: Voevodina
authors.forename: Yu A
authors.initials: YA
authors.lastname: Zolotarev
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: N F
authors.initials: NF
authors.lastname: Myasoedov
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000378:metabolism; D004873:Ergolines; D005625:Frontal Lobe / Q000166:cytology; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051379:Mice; D009496:Neurotensin / Q000378:metabolism*; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010879:Piperazines; D010974:Platelet Aggregation / Q000187:drug effects; D011869:Radioligand Assay; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D018709:Statistics, Nonparametric
chemical_list: D014150:Antipsychotic Agents; D004873:Ergolines; D009842:Oligopeptides; D010879:Piperazines; D012702:Serotonin Antagonists; C058895:1-(2-methoxyphenyl)-4-(4-(2-phthalimido)butyl)piperazine; D012701:Serotonin; D009496:Neurotensin; D007650:Ketanserin; C031649:mesulergine