title: Wireless esophageal pH capsule for patients with gastroesophageal reflux disease: a multicenter clinical study.
abstract: OBJECTIVE
  To investigate the feasibility and safety of pH capsule to monitor pH in patients with gastroesophageal reflux disease (GERD).
  
  
  METHODS
  Ninety-one patients with symptoms suggestive of GERD were enrolled in this study, 46 of whom were randomized to the pH capsule group; the remaining 45 patients used the conventional catheter and pH capsule simultaneously. The pH data and traces were recorded via automatic analysis, and capsule detachment was assessed using X-ray images. All of the patients were required to complete a questionnaire regarding tolerance with the capsule.
  
  
  RESULTS
  The capsules were successfully attached on the first attempt, and no early detachment of the capsules was observed. Compared to the 24-h pH data recorded with the conventional catheter, the data collected with the pH capsule showed no significant differences in 24-h esophageal acid exposure. The measurements of esophageal acid exposure over 24 h collected with the two devices showed a significant correlation (r(2) = 0.996, P < 0.001). Capsule detachment occurred spontaneously in 89 patients, and 2 capsules required endoscopic removal due to chest pain. The capsule was associated with less interference with daily activity.
  
  
  CONCLUSIONS
  The wireless pH capsule provides a feasible and safe method for monitoring gastroesophageal reflux and therefore may serve as an important tool for diagnosing GERD.
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Gan
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Tao
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Shen
authors.affiliation: Xiao-Jun Yang, Tian Gan, Lei Wang, Xiao-Yan Zhao, Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D053705:Capsule Endoscopes / Q000009:adverse effects; D053704:Capsule Endoscopy / Q000009:adverse effects / Q000295:instrumentation*; D002681:China; D050782:Esophageal pH Monitoring / Q000009:adverse effects / Q000295:instrumentation*; D004947:Esophagus / Q000378:metabolism*; D005240:Feasibility Studies; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D013997:Time Factors; D059015:Wireless Technology; D055815:Young Adult
keywords: Conventional catheter; Feasibility; Gastroesophageal reflux disease; Safety; Wireless pH capsule