title: Prognostic impact of supraventricular premature complexes in community-based health checkups: the Ibaraki Prefectural Health Study.
abstract: OBJECTIVE
  The long-term prognosis of subjects with supraventricular premature complexes (SVPCs) remains unclear in the general population. The aim of this study was to examine the prognostic significance of SVPCs in community-based health checkups.
  
  
  RESULTS
  We assessed 63 197 individuals (mean age, 58.8 ± 9.9 years; 67.6% women) who participated in annual community-based health checkups in 1993 and were followed until 2008. The primary endpoint was stroke death, cardiovascular death (CVD), or all-cause death during a 14-year mean follow-up, and the secondary endpoint was first atrial fibrillation (AF) event in subjects without self-reported heart diseases or AF at baseline. Compared with subjects without SVPCs, the multivariate-adjusted hazard ratios (HRs) [95% confidence interval (CI)] of stroke death, CVD, and all-cause death in subjects with SVPCs were 1.24 (0.98-1.56) for men and 1.63 (1.30-2.05) for women, 1.22 (1.04-1.44) for men and 1.48 (1.25-1.74) for women, and 1.08 (0.99-1.18) for men and 1.21 (1.09-1.34) for women, respectively. Atrial fibrillation occurred in 386 subjects during the follow-up (1.05/1000 person-years). The presence of SVPCs at baseline was the significant predictor of AF onset [HRs (95% CI): 4.87 (3.61-6.57) for men and 3.87 (2.69-5.57) for women]. Propensity score matched analyses also revealed the presence of SVPCs was significantly associated with increased risks of AF incidence and CVD even after adjusting the potential confounders.
  
  
  CONCLUSIONS
  The presence of SVPCs in 12-lead electrocardiograms was a strong predictor of AF development, and associated with increased risk of CVD in general population.
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan n.murakoshi@md.tsukuba.ac.jp.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Murakoshi
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.
authors.forename: DongZhu
authors.initials: D
authors.lastname: Xu
authors.affiliation: Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health, Dokkyo Medical University, Mibu, Japan.
authors.forename: Toshimi
authors.initials: T
authors.lastname: Sairenchi
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.
authors.forename: Miyako
authors.initials: M
authors.lastname: Igarashi
authors.affiliation: Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Health and Welfare, Ibaraki Prefectural Office, Mito, Japan.
authors.forename: Fujiko
authors.initials: F
authors.lastname: Irie
authors.affiliation: Ibaraki Health Service Association, Mito, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Tomizawa
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tada
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sekiguchi
authors.affiliation: Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan Department of Public Health Medicine, University of Tsukuba, Tsukuba, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.affiliation: Department of Social and Environmental Medicine, Osaka University, Osaka, Japan.
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.affiliation: Ibaraki Health Service Association, Mito, Japan.
authors.forename: Iwao
authors.initials: I
authors.lastname: Yamaguchi
authors.affiliation: Ibaraki Health Plaza, Ibaraki Health Service Association, Mito, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ota
authors.affiliation: Cardiovascular Division, Institute of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Aonuma
mesh_terms: D000328:Adult; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000401:mortality; D018880:Atrial Premature Complexes / Q000175:diagnosis* / Q000401:mortality; D002318:Cardiovascular Diseases / Q000401:mortality; D003153:Community Health Services; D042241:Early Diagnosis; D004562:Electrocardiography; D004812:Epidemiologic Methods; D005260:Female; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010808:Physical Examination / Q000379:methods; D011379:Prognosis; D020521:Stroke / Q000401:mortality
keywords: Atrial fibrillation; Electrocardiogram; Mortality; Supraventricular premature complex