title: Enzyme-responsive polymer assemblies constructed through covalent synthesis and supramolecular strategy.
abstract: Enzyme-responsive polymer assemblies have proved to be promising candidates for biomaterials, biomedicine and biosensing. Traditionally, these assemblies are prepared by the self-assembly of polymer building blocks which are covalently conjugated with enzyme-responsive moieties. Moreover, a supramolecular strategy has recently been developed for the preparation of enzyme-responsive polymer assemblies where the enzyme-responsive moieties are non-covalently complexed with the polymer building blocks. In addition, kinetic studies have been conducted on the enzyme-responsive behaviour of the polymer assemblies, which paves the way for tuning the response rate of the assemblies in a controlled manner.
authors.affiliation: Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China. xi@mail.tsinghua.edu.cn.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Yuetong
authors.initials: Y
authors.lastname: Kang
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
mesh_terms: D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004798:Enzymes; D008823:Micelles; D011108:Polymers