title: Similarity of GATA-3 Expression between Rat and Human Mammary Glands.
abstract: The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan ; Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan.
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kinoshita
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan.
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yoshizawa
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Emoto
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan.
authors.forename: Michiko
authors.initials: M
authors.lastname: Yuki
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuri
authors.affiliation: Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
authors.affiliation: Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan.
authors.forename: Airo
authors.initials: A
authors.lastname: Tsubura
keywords: GATA-3; immunohistochemistry; mammary gland; mammary tumor; rats