title: Cord blood and consecutive chitotriosidase activity: Relationship to prematurity and early prognosis.
abstract: BACKGROUND
  The aim of this study was to investigate the relationship between plasma chitotriosidase activity, an inflammatory protein secreted mainly from macrophages, and neonatal morbidity and mortality in premature infants.
  
  
  METHODS
  Cord blood chitotriosidase activity was studied in healthy control infants (53 term, group 1; 26 late preterm [33-37 gestational weeks], group 2) and 35 preterm infants (≤ 32 weeks; group 3). In group 3, consecutive samples at 3 h, 24 h, 72 h, 7 days, 14 days, and 36 weeks after conception were also analyzed. Group 3 was also evaluated for mortality, respiratory treatment and bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH) and retinopathy of prematurity (ROP) and necrotizing enterocolitis (NEC).
  
  
  RESULTS
  Cord blood chitotriosidase activity was positively correlated with gestational age and birthweight. SNAPPE-II score was correlated with chitotriosidase activity at 24 h. Consecutive chitotriosidase activity for group 3 was non-significantly higher in infants who died in the early neonatal period. Higher chitotriosidase activity was observed in mechanically ventilated infants than infants treated with non-invasive assisted ventilation. BPD, PDA, IVH and ROP, but not NEC, were related to higher chitotriosidase activity, being significant at some of the time points.
  
  
  CONCLUSIONS
  Neonatal stress such as invasive ventilation may create a risk for the development of BPD, PDA, IVH, and ROP by increasing macrophage activation in preterm infants as reflected in the higher chitotriosidase activity. High chitotriosidase activity may also be associated with disease severity and mortality.
authors.affiliation: Department of Pediatrics, Division of Neonatology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Sezgin
authors.initials: S
authors.lastname: Gunes
authors.affiliation: Department of Pediatrics, Division of Neonatology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yalaz
authors.affiliation: Department of Biochemistry, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Eser
authors.initials: E
authors.lastname: Sozmen
authors.affiliation: Department of Pediatrics, Division of Neonatology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Ozge Altun
authors.initials: OA
authors.lastname: Koroglu
authors.affiliation: Department of Pediatrics, Division of Neonatology, Ege University Faculty of Medicine, Izmir, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kultursay
mesh_terms: D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005865:Gestational Age; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000453:epidemiology; D008297:Male; D009017:Morbidity / Q000639:trends; D011379:Prognosis; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D006596:Hexosaminidases; C086400:chitotriosidase
keywords: chitotriosidase; morbidity; mortality; newborn; prematurity