title: Quercetin declines plasma exposure of metoprolol tartrate in the rat model.
abstract: The study was undertaken to evaluate the effect of quercetin on the pharmacokinetics of Metoprolol tartrate. A single dose in vivo pharmacokinetic study was carried out in rat models. In this study, rats were treated with quercetin (10 mg/kg) and metoprolol tartrate (20 mg/kg) orally and blood samples were collected 0, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 8, 12 h post treatment. Plasma concentration of metoprolol tartrate was estimated using reverse phase-high-performance liquid chromatography method. Area under the plasma concentration-time curve (AUC0-12) of metoprolol has significantly (P < 0.001) decreased by 9.8 times in the metoprolol and quercetin combination group (9434.65 ± 3525.02) when compared with AUC0-12 metoprolol of metoprolol-alone treated group (962.17 ± 242.81). AUC0-∞ of metoprolol has significantly (P < 0.001) decreased by 14.9 times in the combination group (16670.79 ± 12129.06) in comparison to AUC0-∞ of metoprolol of metoprolol-alone treated group (1113.68 ± 441.83). the results obtained herein indicate that quercetin remarkably declines the plasma exposure of metoprolol when concomitantly administered by oral route.
authors.affiliation: Department of Pharmacology, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, India.
authors.forename: Siva R
authors.initials: SR
authors.lastname: Challa
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.
authors.forename: Venkatesh R
authors.initials: VR
authors.lastname: Challa
authors.affiliation: Department of Pharmacology, AMR Memorial College of Pharmacy, Narasaraopet, Guntur, Andhra Pradesh, India.
authors.forename: Satheesh K
authors.initials: SK
authors.lastname: Ragam
keywords: Bioavailability; metoprolol tartrate; organic cation transporter-2; p-glycoprotein; pharmacokinetics; quercetin