title: Transition metal-mediated C═O and C═C bond-forming reactions: a regioselective strategy for the synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrazines.
abstract: A novel and convenient transformation for the regiospecific synthesis of functionalized imidazo[1,2-a]pyridine aldehydes/ketones and 3-vinyl imidazo[1,2-a]pyridines has been developed via copper(I)- and palladium(II)-catalyzed cyclization. The one-pot reaction proceeds smoothly with commercially available catalysts and affords the products in moderate to good yields. It represents an efficient approach for the formation of C-N, C═O, and C═C bonds under mild conditions.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University , Guangzhou 510006, P.R. China.
authors.forename: Hua
authors.initials: H
authors.lastname: Cao
authors.forename: Xiaohang
authors.initials: X
authors.lastname: Liu
authors.forename: Jinqiang
authors.initials: J
authors.lastname: Liao
authors.forename: Jianping
authors.initials: J
authors.lastname: Huang
authors.forename: Huifang
authors.initials: H
authors.lastname: Qiu
authors.forename: Qinlin
authors.initials: Q
authors.lastname: Chen
authors.forename: Yaoyi
authors.initials: Y
authors.lastname: Chen