title: On the integration of the baroreflex control mechanism in a heterogeneous model of the cardiovascular system.
abstract: The aim of the present work is to describe the integration of a mathematical model for the baroreceptor reflex mechanism to provide regulatory action into a dimensionally heterogeneous (3D-1D-0D) closed-loop model of the cardiovascular system. Such heterogeneous model comprises a 1D description of the arterial tree, a 0D network for the venous, cardiac and pulmonary circulations and 3D patient-specific geometries for vascular districts of interest. Thus, the detailed topological description of the arterial network allows us to perform vasomotor control actions in a differentiated way, while gaining insight about the effects of the baroreflex regulation over hemodynamic quantities of interest throughout the entire network. Two examples of application are presented. Firstly, we simulate the hemorrhage in the abdominal aorta artery and analyze the action of the baroreflex over the system. Secondly, the self-regulated closed-loop model is applied to study the influence of the control action in the hemodynamic environment that determines the blood flow pattern in a cerebral aneurism in the presence of a regurgitating aortic valve.
authors.affiliation: Laboratório Nacional de Computação Científica, Av. Getúlio Vargas 333, Quitandinha, 25651-075, Petrópolis, Brazil; Instituto Nacional de Ciência e Tecnologia em Medicina Assistida por Computação Científica, Petrópolis, Brazil. pjblanco@lncc.br.
authors.forename: P J
authors.initials: PJ
authors.lastname: Blanco
authors.forename: P R
authors.initials: PR
authors.lastname: Trenhago
authors.forename: L G
authors.initials: LG
authors.lastname: Fernandes
authors.forename: R A
authors.initials: RA
authors.lastname: Feijóo
mesh_terms: D001012:Aorta, Abdominal / Q000293:injuries; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D006470:Hemorrhage / Q000503:physiopathology; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D014666:Vasomotor System / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology
keywords: baroreceptors; blood flow; closed-loop model; homeostatic mechanism; numerical simulations; vasomotor activity