title: Involvement of p38 MAPK in the induction of Hsp70 during acute thermal stress in red blood cells of the gilthead sea bream, Sparus aurata.
abstract: The present study aimed to examine the expression and activation of MAPKs (p38 MAPK, ERK1/2, and JNKs) in red blood cells (RBCs) of the gilthead sea bream, Sparus aurata, during thermal stress and investigate their involvement in the expression of heat shock proteins. The data showed that only p38 MAPK is detected in RBCs of Sparus aurata and it is phosphorylated and activated during exposure to increased temperature. Induction of Hsp70 in thermally stressed RBCs was abolished in the presence of the p38 MAPK inhibitor, SB203580, suggesting the involvement of the kinase in this response. This mechanism might play a cytoprotective role in the RBCs of the gilthead sea bream.
authors.affiliation: Laboratory of Animal Physiology, Department of Zoology, Faculty of Sciences, School of Biology, University of Thessaloniki, Thessaloniki, Greece.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Feidantsis
authors.forename: Hans O
authors.initials: HO
authors.lastname: Pörtner
authors.forename: Thomais
authors.initials: T
authors.lastname: Markou
authors.forename: Antigone
authors.initials: A
authors.lastname: Lazou
authors.forename: Basile
authors.initials: B
authors.lastname: Michaelidis
mesh_terms: D000818:Animals; D004912:Erythrocytes / Q000378:metabolism*; D029941:Fish Proteins / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response; D021541:Sea Bream / Q000378:metabolism*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
chemical_list: D029941:Fish Proteins; D018840:HSP70 Heat-Shock Proteins; D048051:p38 Mitogen-Activated Protein Kinases