title: Targeted proteomics: a bridge between discovery and validation.
abstract: New technologies in mass spectrometry are beginning to mature and show unique advantages for the identification and quantitation of proteins. In recent years, one of the significant goals of clinical proteomics has been to identify biomarkers that can be used for clinical diagnosis. As technology has progressed, the list of potential biomarkers has grown. However, the verification and validation of these potential biomarkers is increasingly challenging and require high-throughput quantitative assays, targeting specific candidates. Targeted proteomics bridges the gap between biomarker discovery and the development of clinically applicable biomarker assays.
authors.affiliation: Department of Pathology, Johns Hopkins University, Baltimore, MD 21231, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Harlan
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D035843:Biomedical Research / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D011506:Proteins / Q000032:analysis*; D040901:Proteomics
chemical_list: D015415:Biomarkers; D011506:Proteins
keywords: LC–MS; MRM; PRM; SRM; biomarker; proteomics; targeted proteomics