title: Biology of renal recovery: molecules, mechanisms, and pathways.
abstract: Acute kidney injury (AKI) contributes to progressive kidney disease. Although significant advances have been made in the understanding of mechanisms of AKI, less is known about the biological basis that links the initial injury to progressive interstitial fibrosis, tubular dysfunction, and capillary rarefaction. The round table discussion focused on mechanisms of renal recovery and fibrosis following AKI. The knowledge gained by understanding these pathways will serve to identify novel therapeutic targets in the future.
authors.affiliation: Division of Nephrology, Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia Health System, Charlottesville, Va., USA.
authors.forename: Isaah S
authors.initials: IS
authors.lastname: Vincent
authors.forename: Mark D
authors.initials: MD
authors.lastname: Okusa
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D000818:Animals; D015687:Cell Hypoxia; D016922:Cellular Senescence; D016207:Cytokines / Q000502:physiology; D005355:Fibrosis; D006801:Humans; D007249:Inflammation; D007668:Kidney / Q000473:pathology / Q000502:physiology*; D007673:Kidney Cortex Necrosis / Q000209:etiology / Q000473:pathology; D008262:Macrophage Activation; D051379:Mice; D058628:Myofibroblasts / Q000502:physiology; D012038:Regeneration; D051436:Renal Insufficiency, Chronic / Q000209:etiology / Q000517:prevention & control; D017582:Renal Replacement Therapy; D015427:Reperfusion Injury / Q000503:physiopathology
chemical_list: D016207:Cytokines