title: Collaborative care for the treatment of comorbid depression and coronary heart disease: a systematic review and meta-analysis protocol.
abstract: BACKGROUND
  Depression and coronary heart disease (CHD) are frequently comorbid and portend higher morbidity, mortality and poorer quality of life. Prior systematic reviews of depression treatment randomized controlled trials (RCTs) in the population with CHD have not assessed the efficacy of collaborative care. This systematic review aims to bring together the contemporary research on the effectiveness of collaborative care interventions for depression in comorbid CHD populations.
  
  
  METHODS
  Electronic databases (Cochrane Central Register of Controlled Trials MEDLINE, EMBASE, PsycINFO and CINAHL) will be searched using a sensitive search strategy exploding the topics CHD, depression and RCT. Full text inspection and bibliography searching will be conducted, and authors of included studies will be contacted to identify unpublished studies. Eligibility criteria are: population, depression comorbid with CHD; intervention, RCT of collaborative care defined as a coordinated model of care involving multidisciplinary health care providers, including: (a) primary physician and at least one other health professional (e.g. nurse, psychiatrist, psychologist), (b) a structured patient management plan that delivers either pharmacological or non-pharmacological intervention, (c) scheduled patient follow-up and (d) enhanced inter-professional communication between the multiprofessional team; comparison, either usual care, enhanced usual care, wait-list control group or no further treatment; and outcome, major adverse cardiac events (MACE), standardized measure of depression, anxiety, quality of life, cost-effectiveness. Screening, data extraction and risk of bias assessment will be undertaken by two reviewers with disagreements resolved through discussion. Meta-analytic methods will be used to synthesize the data collected relating to the outcomes.
  
  
  CONCLUSIONS
  This review will evaluate the effectiveness and cost-effectiveness of collaborative care for depression in populations primarily with CHD. The results will facilitate integration of evidence-based practice for this precarious population.
  
  
  BACKGROUND
  PROSPERO CRD42014013653.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Tully
authors.affiliation: Department of Rehabilitation Psychology and Psychotherapy, Institute of Psychology, University of Freiburg, Engelbergerstr, 41, Freiburg 79085, Germany. baumeister@psychologie.uni-freiburg.de.
authors.forename: Harald
authors.initials: H
authors.lastname: Baumeister
mesh_terms: D001007:Anxiety / Q000453:epidemiology; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology*; D003863:Depression / Q000453:epidemiology* / Q000628:therapy*; D006801:Humans; D033183:Interdisciplinary Communication; D009203:Myocardial Infarction / Q000453:epidemiology; D010347:Patient Care Planning; D010348:Patient Care Team; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology; D000078202:Systematic Reviews as Topic; D015201:Meta-Analysis as Topic