title: Interleukin-10 gene -592C>A polymorphism and susceptibility to gastric cancer.
abstract: Numerous studies have evaluated the association between the human interleukin-10 gene -592C>A polymorphism and gastric cancer risk. However, the results have been inconsistent. This meta-analysis was designed to resolve these controversies. Systematic searches of the electronic databases Embase, PubMed, and Google Scholar were performed to identify relevant studies. A meta-analysis was performed to examine the association between the interleukin-10 gene -592C>A polymorphism and gastric cancer risk. Odds ratios (OR) and its 95% confidence intervals (CI) were used for statistical analysis. Twelve studies were included in the meta-analysis, which included 2116 gastric cancer cases and 4077 controls. No significant association was found between the interleukin-10 gene -592C>A polymorphism and gastric cancer risk in total population analysis. In stratified analysis, a significant association was found in the Asian subgroup (AA vs AC: OR = 0.79, 95%CI = 0.64-0.98; dominant model: OR = 1.26, 95%CI = 1.04-1.57), and no significant association was observed among Caucasians. In addition, the corresponding pooled ORs were not substantially altered after excluding one study that deviated from Hardy-Weinberg equilibrium in the control group. This meta-analysis supports an association between the interleukin-10 gene -592C>A polymorphism and gastric cancer risk in Asians but not in Caucasians. Further large and well-designed studies are needed to confirm these conclusions.
authors.affiliation: Department of Gastroenterology, Jinan Central Hospital, Jinan, China qiming1982@126.com.
authors.forename: M
authors.initials: M
authors.lastname: Qi
authors.affiliation: Department of Gastroenterology, Jinan Central Hospital, Jinan, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Liu
authors.affiliation: Department of Gastroenterology, Jinan Central Hospital, Jinan, China.
authors.forename: L L
authors.initials: LL
authors.lastname: Pan
authors.affiliation: Department of Gastroenterology, Jinan Central Hospital, Jinan, China.
authors.forename: Y X
authors.initials: YX
authors.lastname: Lin
mesh_terms: D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D015810:Linkage Disequilibrium; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D016753:Interleukin-10