title: Prion protein genotypes of sheep as determined from 3343 samples submitted from Ontario and other provinces of Canada from 2005 to 2012.
abstract: This study analyzed sheep prion protein (PrP) genotypes of samples submitted from Ontario and other provinces of Canada to the Animal Health Laboratory at the University of Guelph, Guelph, Ontario, between 2005 and 2012. In Ontario, the proportion of scrapie-resistant sheep increased from 2005 to 2012 as evidenced by an increase in the ARR haplotype. When Canadian provinces (Alberta, Ontario, Quebec, and Nova Scotia) were compared from 2008 to 2012, a high proportion of scrapie-resistant sheep was found in all the provinces. The proportions of resistant sheep were lower in Alberta and Quebec than in Ontario and Nova Scotia. Alberta had higher proportions of susceptible sheep and a higher frequency of VRQ alleles, and Quebec had a higher frequency of the ARQ allele.
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: Colin
authors.initials: C
authors.lastname: Cameron
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bell-Rogers
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: Rebeccah
authors.initials: R
authors.lastname: McDowall
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: Ana R
authors.initials: AR
authors.lastname: Rebelo
authors.affiliation: Animal Health Laboratory, University of Guelph, Guelph, Ontario N1G 2W1.
authors.forename: Hugh Y
authors.initials: HY
authors.lastname: Cai
mesh_terms: D000818:Animals; D002170:Canada / Q000453:epidemiology; D004247:DNA / Q000737:chemistry / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D011328:Prions / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction / Q000662:veterinary; D012608:Scrapie / Q000453:epidemiology / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000662:veterinary; D012756:Sheep
chemical_list: D011328:Prions; D004247:DNA