title: Obesity preserves myocardial function during blockade of the glycolytic pathway.
abstract: BACKGROUND
  Obesity is defined by excessive accumulation of body fat relative to lean tissue. Studies during the last few years indicate that cardiac function in obese animals may be preserved, increased or diminished.
  
  
  OBJECTIVE
  Study the energy balance of the myocardium with the hypothesis that the increase in fatty acid oxidation and reduced glucose leads to cardiac dysfunction in obesity.
  
  
  METHODS
  30-day-old male Wistar rats were fed standard and hypercaloric diet for 30 weeks. Cardiac function and morphology were assessed. In this paper was viewed the general characteristics and comorbities associated to obesity. The structure cardiac was determined by weights of the heart and left ventricle (LV). Myocardial function was evaluated by studying isolated papillary muscles from the LV, under the baseline condition and after inotropic and lusitropic maneuvers: myocardial stiffness; postrest contraction; increase in extracellular Ca2+ concentration; change in heart rate and inhibitor of glycolytic pathway.
  
  
  RESULTS
  Compared with control group, the obese rats had increased body fat and co-morbities associated with obesity. Functional assessment after blocking iodoacetate shows no difference in the linear regression of DT, however, the RT showed a statistically significant difference in behavior between the control and the obese group, most notable being the slope in group C.
  
  
  CONCLUSIONS
  The energy imbalance on obesity did not cause cardiac dysfunction. On the contrary, the prioritization of fatty acids utilization provides protection to cardiac muscle during the inhibition of glycolysis, suggesting that this pathway is fewer used by obese cardiac muscle.
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Dijon Henrique Salomé de
authors.initials: DH
authors.lastname: Campos
authors.affiliation: Departamento de Esportes, Centro de Educação Física e Desportos, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
authors.forename: André Soares
authors.initials: AS
authors.lastname: Leopoldo
authors.affiliation: Departamento de Esportes, Centro de Educação Física e Desportos, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Lima-Leopoldo
authors.affiliation: Instituto de Ciências da Saúde, Universidade Federal do Mato Grosso, Sinop, MT, Brazil.
authors.forename: André Ferreira do
authors.initials: AF
authors.lastname: Nascimento
authors.affiliation: Escola de Fisioterapia, Universidade Federal do Mato Grosso do Sul, Campo Grande, MS, Brazil.
authors.forename: Silvio Assis de
authors.initials: SA
authors.lastname: Oliveira-Junior
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Danielle Cristina Tomaz da
authors.initials: DC
authors.lastname: Silva
authors.affiliation: Instituto de Ciências da Saúde, Universidade Federal do Mato Grosso, Sinop, MT, Brazil.
authors.forename: Mario Mateus
authors.initials: MM
authors.lastname: Sugizaki
authors.affiliation: Departamento de Bioestatística, Instituto de Ciências Biológicas, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Carlos Roberto
authors.initials: CR
authors.lastname: Padovani
authors.affiliation: Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Cicogna
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006019:Glycolysis / Q000187:drug effects / Q000502:physiology*; D006321:Heart / Q000502:physiology*; D006334:Heart Function Tests; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology; D017208:Rats, Wistar; D013997:Time Factors; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D001786:Blood Glucose; D005227:Fatty Acids; D002118:Calcium