title: Local Probiotic Therapy for Vaginal Candida albicans Infections.
abstract: The high rate of vaginal Candida albicans recurrence is attributed to azole resistance rates as high as 15%. The aim of this study was to determine the clinical and microbiological efficacy of standard azole therapy for treatment of vaginal C. albicans infection alone and in combination with local probiotic as well as the effects on vaginal microbiota. This study included 436 women with vaginal candidiasis randomly assigned to two treatment groups. The first group, with 207 patients (12 dropouts), was administered 150 mg fluconazole and a single vaginal globule of fenticonazole (600 mg) on the same day. The second group of 209 patients (8 dropouts) followed the same treatment schedule; however, ten applications of a vaginal probiotic containing Lactobacillus acidophilus, L. rhamnosus, Streptococcus thermophilus, and L. delbrueckii subsp. bulgaricus were also administered beginning the fifth day after azole treatment. Microbiological analysis of the therapy efficacy in the first treatment group showed C. albicans resistance in over 30% of patients. Clinical complaints persisted after treatment administration in 79.7% (n = 165) of women in this group. Clinical complaints in the second group decreased to 31.1% (n = 65) and microbiological efficacy also improved among investigated parameters, from 93.7% (n = 193) to 95.2% (n = 198). The local application of probiotics after administration of combined azoles for treatment of vaginal C. albicans infections increases therapy efficacy and could prevent relapse.
authors.affiliation: Department of Gynecology, Military Medical Academy, G. Sofijsky Str. 3, 1600, Sofia, Bulgaria, stkovachev@abv.bg.
authors.forename: Stefan Miladinov
authors.initials: SM
authors.lastname: Kovachev
authors.forename: Rossitza Stefanova
authors.initials: RS
authors.lastname: Vatcheva-Dobrevska
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage; D002176:Candida albicans / Q000187:drug effects*; D002181:Candidiasis, Vulvovaginal / Q000628:therapy*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007779:Lactobacillus acidophilus; D048668:Lactobacillus delbrueckii; D052201:Lacticaseibacillus rhamnosus; D008875:Middle Aged; D019936:Probiotics / Q000008:administration & dosage*; D048249:Streptococcus thermophilus; D014621:Vagina / Q000382:microbiology*; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole