title: Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in Argentina.
abstract: One hundred forty-three penicillinase-producing Neisseria gonorrhoeae (PPNG) isolates obtained in Argentina from 2008 and 2012 were examined to detect blaTEM-135 genes and to investigate plasmid profiles and multiantigen sequence types. Forty-two PPNG isolates were found to carry TEM-135, and two contained a new TEM derivative characterized as TEM-220. The blaTEM-135 allele was carried by the Toronto/Rio and African plasmids. Molecular epidemiology revealed that two blaTEM-135 isolates were related to previously described isolates from Thailand and China, indicating a common evolutionary origin.
authors.affiliation: Servicio de Enfermedades de Transmisión Sexual, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Gianecini
authors.affiliation: Servicio de Enfermedades de Transmisión Sexual, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Oviedo
authors.affiliation: Gonococcal Antimicrobial Susceptibility Surveillance Program-Argentina (GASSP-AR), Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Littvik
authors.affiliation: Gonococcal Antimicrobial Susceptibility Surveillance Program-Argentina (GASSP-AR), Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Mendez
authors.affiliation: Gonococcal Antimicrobial Susceptibility Surveillance Program-Argentina (GASSP-AR), Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Piccoli
authors.affiliation: Gonococcal Antimicrobial Susceptibility Surveillance Program-Argentina (GASSP-AR), Ciudad Autónoma de Buenos Aires, Argentina.
authors.forename: S
authors.initials: S
authors.lastname: Montibello
authors.affiliation: Servicio de Enfermedades de Transmisión Sexual, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS Dr. Carlos G. Malbrán, Ciudad Autónoma de Buenos Aires, Argentina pgalarza@anlis.gov.ar.
authors.forename: P
authors.initials: P
authors.lastname: Galarza
mesh_terms: D000595:Amino Acid Sequence; D001118:Argentina / Q000453:epidemiology; D005798:Genes, Bacterial / Q000235:genetics; D006069:Gonorrhea / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D010802:Phylogeny; D010957:Plasmids / Q000235:genetics; D016415:Sequence Alignment; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001618:beta-Lactamases