title: Galectin-1 and immune suppression during radiotherapy.
abstract: Radiotherapy induces galectin-1 (Gal-1) secretion by tumors, which induces CD8(+) T-cell apoptosis and lymphopenia. These effects are substantially decreased by Gal-1 shRNA. Inhibition of Gal-1 may be an effective strategy for overcoming radiation-induced lymphopenia, which may improve clinical outcomes.
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. jwelsh@mdanderson.org.
authors.forename: James W
authors.initials: JW
authors.lastname: Welsh
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Seyedin
authors.affiliation: Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
authors.forename: Maria Angelica
authors.initials: MA
authors.lastname: Cortez
authors.affiliation: Department of Radiation Oncology, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Amit
authors.initials: A
authors.lastname: Maity
authors.affiliation: Department of Radiation Oncology, Perelman School of Medicine, the University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Hahn
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000532:radiotherapy*; D037483:Galectin 1 / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D008231:Lymphopenia / Q000378:metabolism*
chemical_list: D037483:Galectin 1