title: [Significance of biochemical markers in the diagnosis of neuroendocrine tumours and for the follow-up of patients].
abstract: Circulating markers of neuroendocrine tumours are useful tools in the diagnosis of these tumours. Laboratory tests for general biomarkers have acceptable sensitivity for the recognition of neuroendocrine tumours as these biologically active proteins are typically synthesized by all types of neuroendocrine cells. Measurement of chromogranin A is widely used not only in the diagnosis of neuroendocrine tumours but it may predict the prognosis of the diseases and the effect of the antitumor therapy. It is also a useful tool for the detection of residual tumours. Neurendocrine tumours represent a heterogeneous group of tumours with the ability to secrete several hormones and, therefore, measurement of these hormones can also serve as neuroendocrine cell type-specific markers in routine clinical practice. In this review the authors summarize the significance of tumour markers in the diagnosis of neuroendocrine tumours as well as in the management and follow-up of patients with this disease.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Magyar Tudományos Akadémia-Semmelweis Egyetem "Lendület" Örökletes Endokrin Daganatok Kutatócsoport Budapest.
authors.forename: Judit
authors.initials: J
authors.lastname: Tőke
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Élettani Intézet Budapest.
authors.forename: Gábor
authors.initials: G
authors.lastname: Czirják
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest.
authors.forename: Miklós
authors.initials: M
authors.lastname: Tóth
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Magyar Tudományos Akadémia-Semmelweis Egyetem Molekuláris Medicina Kutatócsoport Budapest.
authors.forename: Károly
authors.initials: K
authors.lastname: Rácz
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Laboratóriumi Medicina Intézet Budapest Szentkirályi u. 46. 1088 Magyar Tudományos Akadémia-Semmelweis Egyetem "Lendület" Örökletes Endokrin Daganatok Kutatócsoport Budapest.
authors.forename: Attila
authors.initials: A
authors.lastname: Patócs
mesh_terms: D006916:5-Hydroxytryptophan / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D006063:Chorionic Gonadotropin / Q000097:blood; D002864:Chromogranins / Q000097:blood; D005934:Glucagon / Q000097:blood; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D007328:Insulin / Q000097:blood; D018365:Neoplasm, Residual / Q000097:blood / Q000175:diagnosis; D018358:Neuroendocrine Tumors / Q000097:blood* / Q000175:diagnosis*; D010191:Pancreatic Polypeptide / Q000097:blood; D010751:Phosphopyruvate Hydratase / Q000097:blood; D011159:Population Surveillance / Q000379:methods*; D011237:Predictive Value of Tests; D011379:Prognosis; D012701:Serotonin / Q000097:blood; D013004:Somatostatin / Q000097:blood; D014660:Vasoactive Intestinal Peptide / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D006063:Chorionic Gonadotropin; D002864:Chromogranins; D007328:Insulin; D012701:Serotonin; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D006897:Hydroxyindoleacetic Acid; D010191:Pancreatic Polypeptide; D005934:Glucagon; D006916:5-Hydroxytryptophan; D010751:Phosphopyruvate Hydratase
keywords: 5-hidroxi-indolecetsav; 5-hydroxyindoleacetic-acid; chromogranin A; neuroendocrine tumour; neuroendokrin tumormarker