title: Basis of selection of first and second line highly active antiretroviral therapy for HIV/AIDS on genetic barrier to resistance: a literature review.
abstract: The effectiveness of combination antiretroviral therapy (cART) continues to improve as treatment choices expand with the development of new antiretroviral agents and regimens. However, the successful long-term treatment of HIV/AIDS is under threat from the emergence of drug-resistant strains to multiple agents and entire drug classes.
authors.affiliation: Makerere University, College of Health Sciences, Infectious Diseases Institute, Kampala, Uganda.
authors.forename: Christine
authors.initials: C
authors.lastname: Katusiime
authors.affiliation: Makerere University, College of Health Sciences, Department of Medicine, Kampala, Uganda.
authors.forename: Ponsiano
authors.initials: P
authors.lastname: Ocama
authors.affiliation: Makerere University, College of Health Sciences, Infectious Diseases Institute, Kampala, Uganda.
authors.forename: Andrew
authors.initials: A
authors.lastname: Kambugu
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D024882:Drug Resistance, Viral / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents
keywords: HIV resistance; genetic barrier; highly active antiretroviral therapy