title: Amphiphilic copolymer coated upconversion nanoparticles for near-infrared light-triggered dual anticancer treatment.
abstract: The light-triggered controlled release of anticancer drugs accompanied with NIR-responsive photodynamic therapy was prepared via a self-assembly process. Firstly, Mn(2+)-doped upconversion nanoparticles (UCNPs) were coated with a mesoporous silica shell and modified with photosensitizer (Chlorin e6) and long alkyl chains. And then the NIR light-responsive amphiphilic copolymer containing 9,10-dialkoxyanthracene groups was synthesized and then coated as the outermost layer. Upon irradiation with a 980 nm laser, the CCUCNPs@PM would absorb and then convert the NIR light to higher-energy visible red light (660 nm) via the UCNPs-based core, which could excite Chlorin e6 (Ce-6) to produce singlet oxygen ((1)O2). Then the (1)O2-sensitive dialkoxyanthracene group in the amphiphilic copolymer would be degraded and detach from the surface of the CCUCNPs@PM, followed by the controlled release of the pre-loaded drugs and the photodynamic therapy for cancer cells caused by the excess (1)O2. In vitro and in vivo experiments also demonstrated that the drug-loaded CCUCNPs@PM possessed better therapeutic efficacy compared with vacant ones. Therefore, the NIR light-controlled chemotherapy and photodynamic therapy could be realized simultaneously by CCUCNPs@PM.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, 215123, China. linajun@suda.edu.cn lujm@suda.edu.cn.
authors.forename: Shun
authors.initials: S
authors.lastname: Yang
authors.forename: Najun
authors.initials: N
authors.lastname: Li
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
authors.forename: Wenwei
authors.initials: W
authors.lastname: Sha
authors.forename: Dongyun
authors.initials: D
authors.lastname: Chen
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xu
authors.forename: Jianmei
authors.initials: J
authors.lastname: Lu
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D002735:Chlorophyllides; D003131:Combined Modality Therapy; D004058:Diffusion; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D007259:Infrared Rays / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods; D053769:Nanocapsules / Q000008:administration & dosage* / Q000737:chemistry / Q000648:ultrastructure; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011166:Porphyrins / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D002735:Chlorophyllides; D053769:Nanocapsules; D017319:Photosensitizing Agents; D011108:Polymers; D011166:Porphyrins; C062985:phytochlorin; D004317:Doxorubicin