title: [Effect of cerebrolysin on disadaptation syndrome in patients with ischemic stroke].
abstract: Objective. To study the neurotrophic and neuroprotective effects of cerebrolysin on the autonomic homeostasis in patients with ischemic stroke (IS) using heart rate variability (HRV) method. Material and methods. Thirty patients, 12 men and 18 women (mean age 65.0±7.8 years) in the acute stage of IS were enrolled in the study. An analysis of the disease was based on the dynamics of autonomic homeostasis indicators in the study of HRV in relation to clinical symptoms and results of psychological testing. Results and сonclusion. Compared to the controls, significant positive changes in the indicators of HRV spectrum analysis and cardiointervalography as well as the reduction in neurological deficit in patients treated with cerebrolysin, which has neurotrophic and neuroprotective properties, was found.
authors.affiliation: GBOU VPO "Kazanskiĭ gosudarstvennyĭ meditsinskiĭ universitet", Kazan'
authors.forename: E Z
authors.initials: EZ
authors.lastname: Iakupov
authors.forename: K S
authors.initials: KS
authors.lastname: Ovsiannikova