title: Dynamic Changes in Phenotypic Groups in Patients with Stable Angina Pectoris after Treatment with Xinxuekang Capsule: A Randomized Controlled Trial.
abstract: OBJECTIVE
  To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients with stable angina pectoris (SAP) after Xinxuekang capsule treatment.
  
  
  METHODS
  Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling (NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest, palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on Days 0, 14, 28, 42, and 56.
  
  
  RESULTS
  Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group.
  
  
  CONCLUSIONS
  Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic variation of SAP may be determined, to improve the development and modification of treatment regimens.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Wang
authors.forename: Jian-Yuan
authors.initials: JY
authors.lastname: Tang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Yu
authors.forename: Bi-Wei
authors.initials: BW
authors.lastname: Chen
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wu
authors.forename: Li-Ya
authors.initials: LY
authors.lastname: Su
authors.forename: Zhi-Wei
authors.initials: ZW
authors.lastname: Jing
authors.forename: Si-Yuan
authors.initials: SY
authors.lastname: Hu
authors.forename: Xiang-Ling
authors.initials: XL
authors.lastname: Liu
authors.forename: Xi-Yan
authors.initials: XY
authors.lastname: Yang
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Dong
authors.forename: Dong-Hai
authors.initials: DH
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Xue
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Zhuo-Ming
authors.initials: ZM
authors.lastname: Li
authors.forename: Shu-Rong
authors.initials: SR
authors.lastname: Liu
authors.forename: Song-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Qi-Guang
authors.initials: QG
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Dongzhimennei Nanxiaojie 16#, Beijing 100700, China. zhonw@vip.sina.com.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Chun-Ti
authors.initials: CT
authors.lastname: Shen
authors.forename: Yong-Yan
authors.initials: YY
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D060050:Angina, Stable / Q000175:diagnosis* / Q000188:drug therapy*; D002214:Capsules; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D027561:Salvia miltiorrhiza; D016896:Treatment Outcome
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; C000607514:di'ao xinxuekang; C028972:dan-shen root extract