title: The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages.
abstract: Brain tumor-initiating cells (BTICs) become less tumorigenic when co-cultured with microglia/macrophages (M/Ms) isolated from subjects not affected by glioma, but not when exposed to the M/Ms of glioma patients. Microglial cells and macrophages from glioma patients, however, can be reactivated by non-toxic doses of amphotericin B to curb the growth of BTICs in vitro and in vivo.
authors.affiliation: Hotchkiss Brain Institute and Department of Clinical Neurosciences; University of Calgary; Calgary, Canada.
authors.forename: Susobhan
authors.initials: S
authors.lastname: Sarkar
authors.affiliation: Hotchkiss Brain Institute and Department of Clinical Neurosciences; University of Calgary; Calgary, Canada.
authors.forename: V Wee
authors.initials: VW
authors.lastname: Yong
keywords: amphotericin; glioma stem cells; innate immunity; microglia; reactivation