title: Effects of senktide, a neurokinin 3 receptor agonist, on luteinizing hormone secretion and follicular development in anestrous Shiba goats: a pilot study.
abstract: BACKGROUND
  Recent studies suggest that neurokinin B and its receptor, neurokinin 3 receptor, have an essential role in the regulation of gonadotropin-releasing hormone and luteinizing hormone (LH) release in several mammalian species. As the first trial, this pilot study reports the effect of intravenous treatment with senktide, a selective agonist of neurokinin 3 receptor, on LH secretion, follicular development in female goats that were clinically diagnosed with anestrus.
  
  
  RESULTS
  Anestrous goats were intravenously administered 200 nmol senktide at 4-h intervals for 24 h. Most of them examined (5/6 cases) showed a pulsatile increase in LH secretion after each injection of senktide, whereas the remaining one case showed a surge-like increase of LH secretion. Ovulation was confirmed in 5/6 cases at the range of 48-96 h after the beginning of treatment.
  
  
  CONCLUSIONS
  This pilot study demonstrated that intravenous treatment with senktide has therapeutic action in goats with anestrus by inducing LH release, which could promote follicular development and ovulation.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Endo
authors.affiliation: Laboratory of Veterinary Reproduction, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-city, Tokyo 183-8509, Japan. tomomit@cc.tuat.ac.jp.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000780:Anestrus / Q000097:blood / Q000187:drug effects*; D000818:Animals; D004334:Drug Administration Schedule; D004958:Estradiol / Q000097:blood; D004971:Estrus / Q000187:drug effects; D005260:Female; D005299:Fertility Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006041:Goats; D007262:Infusions, Intravenous; D007986:Luteinizing Hormone / Q000097:blood*; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism; D010060:Ovulation / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010865:Pilot Projects; D018042:Receptors, Neurokinin-3 / Q000819:agonists* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
chemical_list: D005299:Fertility Agents; D010446:Peptide Fragments; D018042:Receptors, Neurokinin-3; C054724:senktide; D013373:Substance P; D004958:Estradiol; D007986:Luteinizing Hormone