title: Diagnostic performance of computed tomography for detection of concomitant coronary disease in hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  To evaluate the diagnostic performance of computed tomography (CT) in patients with hypertrophic cardiomyopathy (HCM) and suspected coexistent coronary artery diseases (CADs).
  
  
  METHODS
  Sixty patients were enrolled in this study. Cardiac CT examination included CT coronary angiography (CTCA) and delayed enhancement CT. CT performance in evaluation of the coronary artery was assessed and compared with that of catheter-based coronary angiography (CA). The left ventricle (LV) wall thickness, functional indices and myocardial delayed enhancement (MDE) were measured via cardiac magnetic resonance (CMR) and CT images.
  
  
  RESULTS
  Compared with catheter-based CA, CTCA produced a 100 % (24/24) sensitivity, a 94.4 % (34/36) specificity, a 92.3 % (24/26) positive predictive value and a 100 % (34/34) negative predictive value. CT-measured LV wall thickness and functional indices were correlated with those measured via CMR (P < 0.01), though the CT-measured values were smaller than the CMR-measured values. Bland-Altman analysis showed the volume of the focal MDE determined via CT was slightly smaller than that determined using CMR (mean difference: 0.3 cm(3)).
  
  
  CONCLUSIONS
  For patients with HCM and suspected coexistent CAD, this comprehensive cardiac CT protocol can be helpful in ruling out coronary stenosis and can provide information regarding morphology, function and tissue characterization of the LV myocardium.
authors.affiliation: Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China, 100029.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Xiaohai
authors.initials: X
authors.lastname: Ma
authors.forename: Hailong
authors.initials: H
authors.lastname: Ge
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Zhanhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Teraoka
authors.forename: Zhanming
authors.initials: Z
authors.lastname: Fan
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards*; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology