title: Assembly, postsynthetic modification and hepatocyte targeting by multiantennary, galactosylated soft structures.
abstract: Enzyme modifiable, hollow self-assembled structures offer an excellent scope for multiantennary delivery vectors. Herein, we report synthesis and applications of bis-galactose lysine based supramolecular ensembles, which possess surface galactose moieties amenable to enzymatic modifications. This post-synthetic modification generates reactive aldehyde groups, which could possibly serve as dynamic anchors for crosslinking and cell adhesion.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, UP, India. sverma@iitk.ac.in.
authors.forename: Anisha
authors.initials: A
authors.lastname: Thomas
authors.forename: Akansha
authors.initials: A
authors.lastname: Shukla
authors.forename: Sri
authors.initials: S
authors.lastname: Sivakumar
authors.forename: Sandeep
authors.initials: S
authors.lastname: Verma
mesh_terms: D000588:Amines / Q000737:chemistry; D002448:Cell Adhesion; D005690:Galactose / Q000737:chemistry / Q000378:metabolism*; D005692:Galactose Oxidase / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D010069:Oxadiazoles / Q000737:chemistry
chemical_list: D000588:Amines; C121459:N-methyl-4-amino-7-nitrobenzofurazan; D010069:Oxadiazoles; D006046:Gold; D005692:Galactose Oxidase; D005690:Galactose