title: Making microvascular networks work: angiogenesis, remodeling, and pruning.
abstract: The adequate and efficient functioning of the microcirculation requires not only numerous vessels providing a large surface area for transport but also a structure that provides short diffusion distances from capillaries to tissue and efficient distribution of convective blood flow. Theoretical models show how a combination of angiogenesis, remodeling, and pruning in response to hemodynamic and metabolic stimuli, termed "angioadaptation," generates well organized, functional networks.
authors.affiliation: Department of Physiology and CCR, Charité, Berlin, Germany; Deutsches Herzzentrum Berlin, Berlin, Germany; axel.pries@charite.de.
authors.forename: Axel R
authors.initials: AR
authors.lastname: Pries
authors.affiliation: Department of Physiology, University of Arizona, Tucson, Arizona.
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Secomb
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004058:Diffusion; D006439:Hemodynamics; D006801:Humans; D008833:Microcirculation; D055806:Microvessels / Q000033:anatomy & histology / Q000502:physiology*; D008955:Models, Cardiovascular; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic