title: Epstein-Barr virus positive inflammatory pseudotumor of the liver: report of a challenging case and review of the literature.
abstract: Inflammatory pseudotumor (IPT) is an uncommon, benign lesion of unclear etiology, which is sometimes associated with Epstein-Barr virus (EBV). In this study, we discuss a case of hepatic EBV positive IPT and discuss mimickers, prognosis, and treatment. The case we describe was located in the liver and composed of a mixture of spindle cells and polymorphic inflammatory cells with areas of necrosis. The spindle cells were negative for CAM5.2, ALK1, CD21, CD23, CD35, actin, S-100, and CD34. EBV-encoded small RNA in situ hybridization showed a large number of EBV positive cells. The diagnosis of hepatic EBV positive IPT with uncertain biological behavior was issued, presenting numerous difficulties with diagnostic and therapeutic challenges.
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: You
authors.affiliation: Department of Hematology and Laboratory Medicine, Moffitt Cancer Center and University of South Florida, Tampa, FL.
authors.forename: Haipeng
authors.initials: H
authors.lastname: Shao
authors.affiliation: Honors College, University of South Florida, Tampa, FL.
authors.forename: Katherine
authors.initials: K
authors.lastname: Bui
authors.affiliation: Department of Anatomic Pathology, Moffitt Cancer Center and University of South Florida, Tampa, FL.
authors.forename: Marilyn
authors.initials: M
authors.lastname: Bui
authors.affiliation: Department of Gastrointestinal Surgery, Moffitt Cancer Center and University of South Florida, Tampa, FL.
authors.forename: Jason
authors.initials: J
authors.lastname: Klapman
authors.affiliation: Department of Pathology, Peking Union Medical College Hospital, Beijing, China.
authors.forename: Quancai
authors.initials: Q
authors.lastname: Cui
authors.affiliation: Department of Anatomic Pathology, Moffitt Cancer Center and University of South Florida, Tampa, FL Chemical Biology and Molecular Medicine Program, Moffitt Cancer Center, Tampa, FL, USA Domenico.Coppola@moffitt.org.
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D006104:Granuloma, Plasma Cell / Q000209:etiology*; D004854:Herpesvirus 4, Human; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000821:virology*; D008297:Male; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D015703:Antigens, CD
keywords: Anaplastic lymphoma kinase; Epstein-Barr virus; Inflammatory myofibroblastic tumor; Inflammatory pseudotumor; Inflammatory pseudotumor-like follicular dendritic cell tumor; liver