title: Novel strategies for managing pancreatic cancer.
abstract: With the incidence reports of pancreatic cancer increasing every year, research over the last several decades has been focused on the means to achieve early diagnosis in patients that are at a high risk of developing the malignancy. This review covers current strategies for managing pancreatic cancer and further discusses efforts in understanding the role of early onset symptoms leading to tumor progression. Recent investigations in this discussion include type 3c diabetes, selected biomarkers and pathways related to pancreatic intraepithelial neoplasia lesions, drug resistance, and advances in nanomedicine which may provide significant solutions for improving early detection and treatments in future medicine.
authors.affiliation: Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: Welley S
authors.initials: WS
authors.lastname: Loc
authors.affiliation: Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: Jill P
authors.initials: JP
authors.lastname: Smith
authors.affiliation: Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: Gail
authors.initials: G
authors.lastname: Matters
authors.affiliation: Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: Mark
authors.initials: M
authors.lastname: Kester
authors.affiliation: Welley S Loc, Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
authors.forename: James H
authors.initials: JH
authors.lastname: Adair
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D055088:Early Detection of Cancer / Q000639:trends; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000639:trends; D006801:Humans; D009154:Mutation; D050997:Nanomedicine / Q000639:trends*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000235:genetics / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010641:Phenotype; D011237:Predictive Value of Tests; D012307:Risk Factors; D015398:Signal Transduction; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D005819:Genetic Markers
keywords: Biomarkers; Diagnosis; Nanomedicine; Pancreatic cancer; Signaling pathways; Treatment