title: Associations of cold receptor TRPM8 gene single nucleotide polymorphism with blood lipids and anthropometric parameters in Russian population.
abstract: We analyzed associations of single nucleotide polymorphisms rsl13004520 (R247T), rs11562975 (L250L), rs7593557 (S419N), rs11563208 (I1016I), and rs11563071 (V1058V) of the cold receptor TRPM8 (2q37.1) gene with blood plasma lipids and anthropometric parameters in Russian population (randomly chosen residents of Novosibirsk: 507 women and 459 men, mean age 57 years). The studied polymorphisms are localized in regions encoding NH2-terminal (R247T, L250L, S419N) and COOH-terminal (I1016I, V1058V) cytoplasmic domains of the channel. We showed association of single nucleotide polymorphism V1058V with the levels of total cholesterol and LDL and HDL cholesterol, and association of I1016I polymorphism with triglyceride content. Polymorphisms L250L and S419N correlated with anthropometric parameters (body mass index and waist and hip circumferences).
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia, potapove@ngs.ru.
authors.forename: T A
authors.initials: TA
authors.lastname: Potapova
authors.forename: V N
authors.initials: VN
authors.lastname: Babenko
authors.forename: V F
authors.initials: VF
authors.lastname: Kobzev
authors.forename: A G
authors.initials: AG
authors.lastname: Romashchenko
authors.forename: V N
authors.initials: VN
authors.lastname: Maksimov
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000886:Anthropometry; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012426:Russia; D050053:TRPM Cation Channels / Q000235:genetics*; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D008055:Lipids; D050053:TRPM Cation Channels; C425966:TRPM8 protein, human; D014280:Triglycerides; D002784:Cholesterol