title: Degradable glycine-based photo-polymerizable polyphosphazenes for use as scaffolds for tissue regeneration.
abstract: Photo-polymerizable scaffolds are designed and prepared via short chain poly(organo)phosphazene building blocks bearing glycine allylester moieties. The polyphosphazene was combined with a trifunctional thiol and divinylester in various ratios, followed by thiol-ene photo-polymerization to obtain porous matrices. Degradation studies under aqueous conditions showed increasing rates in correlation with the polyphosphazene content. Preliminary cell studies show the non-cytotoxic nature of the polymers and their degradation products, as well as the cell adhesion and proliferation of adipose-derived stem cells.
authors.affiliation: Institute of Polymer Chemistry, Johannes Kepler University Linz, Welser Straße 42, Leonding, A-4060, Austria.
authors.forename: Sandra
authors.initials: S
authors.lastname: Rothemund
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Aigner
authors.forename: Aitziber
authors.initials: A
authors.lastname: Iturmendi
authors.forename: Maria
authors.initials: M
authors.lastname: Rigau
authors.forename: Branislav
authors.initials: B
authors.lastname: Husár
authors.forename: Florian
authors.initials: F
authors.lastname: Hildner
authors.forename: Eleni
authors.initials: E
authors.lastname: Oberbauer
authors.forename: Martina
authors.initials: M
authors.lastname: Prambauer
authors.forename: Gbenga
authors.initials: G
authors.lastname: Olawale
authors.forename: Reinhard
authors.initials: R
authors.lastname: Forstner
authors.forename: Robert
authors.initials: R
authors.lastname: Liska
authors.forename: Klaus R
authors.initials: KR
authors.lastname: Schröder
authors.forename: Oliver
authors.initials: O
authors.lastname: Brüggemann
authors.forename: Ian
authors.initials: I
authors.lastname: Teasdale
mesh_terms: D000273:Adipose Tissue / Q000166:cytology; D055119:Elastic Modulus; D005260:Female; D005998:Glycine / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization / Q000528:radiation effects*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D016062:Porosity; D012038:Regeneration; D017550:Spectroscopy, Fourier Transform Infrared; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014057:Tomography, X-Ray Computed; D014466:Ultraviolet Rays
chemical_list: D009943:Organophosphorus Compounds; D011108:Polymers; C108974:poly(phosphazene); D005998:Glycine
keywords: bioerosion; degradable polymers; photo-polymerization; polyphosphazenes; tissue engineering