title: The Proteome of a Healthy Human during Physical Activity under Extreme Conditions.
abstract: The review examines the new approaches in modern systems biology, in terms of their use for a deeper understanding of the physiological adaptation of a healthy human in extreme environments. Human physiology under extreme conditions of life, or environmental physiology, and systems biology are natural partners. The similarities and differences between the object and methods in systems biology, the OMICs (proteomics, transcriptomics, metabolomics) disciplines, and other related sciences have been studied. The latest data on environmental human physiology obtained using systems biology methods are discussed. The independent achievements of systems biology in studying the adaptation of a healthy human to physical activity, including human presence at high altitude, to the effects of hypoxia and oxidative stress have been noted. A reasonable conclusion is drawn that the application of the methods and approaches used in systems biology to study the molecular pattern of the adaptive mechanisms that develop in the human body during space flight can provide valuable fundamental knowledge and fill the picture of human metabolic pathways.
authors.affiliation: SSC RF Institute for Biomedical Problems, Russian Academy of Sciences, Khoroshevskoye shosse, 76a, 123007, Moscow, Russia.
authors.forename: I M
authors.initials: IM
authors.lastname: Larina
authors.affiliation: Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Akad. Lavrentiev Ave., 10, 630090, Novosibirsk, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Ivanisenko
authors.affiliation: Institute of Biochemical Physics, Russian Academy of Sciences, Kosygina Str., 4, 119334, Moscow, Russia.
authors.forename: E N
authors.initials: EN
authors.lastname: Nikolaev
authors.affiliation: SSC RF Institute for Biomedical Problems, Russian Academy of Sciences, Khoroshevskoye shosse, 76a, 123007, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Grigorev
keywords: integrative physiology; proteomics; space flight; systems biology