title: [Colorectal cancer in ulcerative colitis].
abstract: Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC), but the risk is lower than previously estimated. In this review on the evidence of CRC risk in the UC population, we find that the effect of chemoprevention appears unproven. Surveillance should be offered in dedicated centres and restricted to subgroups with extensive disease, young age at unset, dysplastic findings or an additional diagnosis of primary sclerosing cholangitis. The use of random biopsies should be replaced by chromoendoscopy for targeting biopsies towards areas with abnormal appearance.
authors.affiliation: Ønsbækvej 27, 8541 Skødstrup. kimlauge@rm.dk.
authors.forename: Kim Bøgelund
authors.initials: KB
authors.lastname: Laugesen
authors.forename: Anders
authors.initials: A
authors.lastname: Tøttrup
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D015209:Cholangitis, Sclerosing / Q000150:complications; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D006801:Humans; D011159:Population Surveillance; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal