title: Elevated Serum Mannose-Binding Lectin Levels Are Associated with Poor Outcome After Acute Ischemic Stroke in Patients with Type 2 Diabetes.
abstract: The activation of the complement system may be involved in the pathology of stroke and type 2 diabetes (T2DM). We therefore evaluated the long-term prognostic value of early measurement of serum mannose-binding lectin (MBL) levels, an activator of the complement system, in Chinese T2DM with acute ischemic stroke (AIS). Serum MBL levels were determined in T2DM patients with AIS (N = 188). The adjudicated end points were 1-year functional outcomes and mortality. The prognostic value of MBL was compared with the National Institutes of Health Stroke Scale score and with other known outcome predictors. Patients with an unfavorable outcomes and nonsurvivors had significantly increased MBL levels on admission (P < 0.0001 and P < 0.0001). Multivariate logistic regression analysis adjusted for common risk factors showed that MBL was an independent predictor of functional outcome (odds ratio (OR) = 8.99, 95% CI 2.21-30.12) and mortality (OR = 13.22, 95% CI 2.05-41.21). The area under the receiver operating characteristic curve of MBL was 0.75 (95% CI 0.68-0.83) for functional outcome and 0.85 (95% CI 0.80-0.90) for mortality. In type 2 diabetic patients with stroke, high levels of MBL predict future functional outcomes and mortality. This indicated that the elevated MBL levels may play a significant role in the pathology of the subsequent damage and that the pathways leading to complement activation warrant further exploration as potential therapeutic targets to improve the prognosis for these patients.
authors.affiliation: Department of Neurology, Laiwu People's Hospital, No.001, Xuehudajie, Laiwu, 271100, People's Republic of China.
authors.forename: Fang-Yu
authors.initials: FY
authors.lastname: Song
authors.affiliation: Department of Neurology, Laiwu People's Hospital, No.001, Xuehudajie, Laiwu, 271100, People's Republic of China.
authors.forename: Meng-Hai
authors.initials: MH
authors.lastname: Wu
authors.affiliation: Department of Neurology, Laiwu People's Hospital, No.001, Xuehudajie, Laiwu, 271100, People's Republic of China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Zhu
authors.affiliation: Department of Cardiology, Laiwu People's Hospital, Laiwu, 271100, People's Republic of China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Laiwu People's Hospital, No.001, Xuehudajie, Laiwu, 271100, People's Republic of China. qiqde534@126.com.
authors.forename: Qin-De
authors.initials: QD
authors.lastname: Qi
authors.affiliation: Department of Rehabilitation, Linyi People's Hospital, No.27, Jiefang Road, Linyi City, 276003, Shandong Province, People's Republic of China. skyworth949@126.com.
authors.forename: Chang-Li
authors.initials: CL
authors.lastname: Lou
mesh_terms: D000368:Aged; D019540:Area Under Curve; D015415:Biomarkers; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications / Q000276:immunology / Q000401:mortality; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003167:Complement Activation; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000502:physiology; D008875:Middle Aged; D059906:Neuroimaging; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin
keywords: Acute ischemic stroke; Mannose-binding lectin; One-year outcome; Prognostic biomarker; Type 2 diabetes