title: Lewis base-promoted rearrangement of allylic cyanohydrins: construction of functionalized nitriles bearing 1,3-diketone moieties.
abstract: A novel Lewis base-promoted rearrangement of allylic cyanohydrins has been developed, in which the cyano group was rearranged, directly coupled with the generation of new functional groups. This protocol provides a unique and facile way to prepare highly functionalized nitriles bearing 1,3-diketone moieties under mild reaction conditions. Furthermore, the synthetic transformations of the functionalized products have also been demonstrated.
authors.affiliation: Department of Organic Chemistry, College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
authors.forename: Yan-Jing
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Qi-Lan
authors.initials: QL
authors.lastname: Hou
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Wang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Liao
mesh_terms: D001669:Biochemical Phenomena; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007659:Ketones; D058115:Lewis Bases; D009570:Nitriles; C430593:cyanohydrin