title: Oligometastasis and oligo-recurrence: more than a mirage.
abstract: The standard treatment choice for cancer metastasis has been systemic management, including cytotoxic chemotherapy, hormonal manipulation, and targeted therapy. Emerging evidence has shown an oligometastatic state, an intermediate state between limited primary cancer and polymetastatic cancer, in which local therapy for metastatic lesions results in satisfactory survival comparable to non-metastatic disease. We provide a comprehensive introduction of evidence from experimental and clinical studies in favor of the oligometastatic phenotype, we review the efficacy and safety of surgery and stereotactic body radiotherapy in the treatment of oligometastases, and finally, we discuss the way to differentiate the oligometastatic state from polymetastasis.
authors.affiliation: Wuhan Union Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. proton948@126.com.
authors.forename: Fang
authors.initials: F
authors.lastname: Huang
authors.affiliation: Wuhan Union Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. xhzlwg@163.com.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.affiliation: Wuhan Union Hospital, TongJi Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. yangky71@aliyun.com.
authors.forename: Kunyu
authors.initials: K
authors.lastname: Yang
mesh_terms: D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery*; D009369:Neoplasms / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis