title: Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions.
abstract: Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease. By using eight-colour flow cytometry, we have identified a previously unreported population of CD1a(+)/CD3(+) T-cells in LCH lesions. The expression of CD1a is regarded as a hallmark of this disease; however, it has always been presumed that it was only expressed by pathogenic Langerhans cells (LCs). We have now detected CD1a expression by a range of T-cell subsets within all of the LCH lesions that were examined, establishing that CD1a expression in these lesions is no longer restricted to pathogenic LCs. The presence of CD1a(+) T-cells in all of the LCH lesions that we have studied to date warrants further investigation into their biological function to determine whether these cells are important in the pathogenesis of LCH.
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia; School of Health Sciences, Federation University, Mt Helen, Victoria, Australia.
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: West
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia; School of Health Sciences, Federation University, Mt Helen, Victoria, Australia.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Olsen
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia; School of Health Sciences, Federation University, Mt Helen, Victoria, Australia.
authors.forename: Jenée M
authors.initials: JM
authors.lastname: Mitchell
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia; School of Health Sciences, Federation University, Mt Helen, Victoria, Australia.
authors.forename: Ross E
authors.initials: RE
authors.lastname: Priddle
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Luke
authors.affiliation: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Selma Olsson
authors.initials: SO
authors.lastname: Akefeldt
authors.affiliation: Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Jan-Inge
authors.initials: JI
authors.lastname: Henter
authors.affiliation: School of Science, Information Technology and Engineering, Federation University, Mt Helen, Victoria, Australia.
authors.forename: Christopher
authors.initials: C
authors.lastname: Turville
authors.affiliation: Fiona Elsey Cancer Research Institute, Ballarat, Victoria, Australia; School of Health Sciences, Federation University, Mt Helen, Victoria, Australia.
authors.forename: George
authors.initials: G
authors.lastname: Kannourakis
mesh_terms: D018949:Antigens, CD1 / Q000096:biosynthesis* / Q000276:immunology; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D006646:Histiocytosis, Langerhans-Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen