title: Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats.
abstract: This study was done to evaluate possible hepatoprotective effects of aqueous leaf extracts of Basella alba in comparison with silymarin in paracetamol-induced hepatotoxicity in albino rats. Six groups of six albino rats each received orally for 6 weeks, vehicle, paracetamol (2 g/kg/day), paracetamol (2 g/kg/day) plus silymarin (50 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (60 mg/kg/day), paracetamol (2 g/kg/day) plus B. alba extract (80 mg/kg/day) and paracetamol (2 g/kg/day) plus B. alba extract (100 mg/kg/day). Hepatoprotective effect was evaluated by comparing serum bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, proteins, alkaline phosphatase and liver histopathology. Results were represented as mean ± SEM. One-way ANOVA was done followed by post hoc Tukey's test with a highly significance level of P < 0.001. Aqueous leaf extracts of B. alba 100 mg/kg/day orally had significant hepatoprotective effect in paracetamol-induced hepatotoxicity in albino rats. The results were well comparable and even in some respects superior to standard drug silymarin.
authors.affiliation: a Nalmuri Block Primary Health Centre , Block: Bhangore-I, South 24, Parganas , West Bengal , India.
authors.forename: Saibal
authors.initials: S
authors.lastname: Das
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bandyopadhyay
authors.forename: Anand
authors.initials: A
authors.lastname: Ramasamy
authors.forename: Somnath
authors.initials: S
authors.lastname: Mondal
mesh_terms: D000082:Acetaminophen / Q000633:toxicity; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D019684:Magnoliopsida / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D012838:Silymarin / Q000494:pharmacology
chemical_list: D010936:Plant Extracts; D012838:Silymarin; D000082:Acetaminophen
keywords: Basella alba; hepatoprotective effects; hepatotoxicity; paracetamol; silymarin