title: Osteopoikilosis: report of a familial case and review of the literature.
abstract: Osteopoikilosis (OPK) is a benign, rare, asymptomatic osteosclerotic bone dysplasia which is inherited as an autosomal dominant trait. It may develop during childhood and persists throughout life. Diagnosis is usually made incidentally according to radiographs. It may be confused with other conditions, such as osteoblastic metastases. OPK must be in differential diagnosis when multiple, small, well-defined, symmetric bone lesions are identified on plain radiograph to avoid alarming the patient with more serious disease and misdiagnosis. Bone scintigraphy is normal and useful for differential diagnosis. Although it is usually asymptomatic, effusion and joint pain can be found in 15-20 % of patients. In this study, we report a 17-year-old boy who suffers from low back pain and has a mother with similar involvement. He was diagnosed OPK radiologically. We also review the clinical manifestation, pathophysiology, diagnosis and treatment of OPK in this paper.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey, korkmazmfurkan@gmail.com.
authors.forename: Muhammet Furkan
authors.initials: MF
authors.lastname: Korkmaz
authors.forename: Murat
authors.initials: M
authors.lastname: Elli
authors.forename: Mehmet Burak
authors.initials: MB
authors.lastname: Özkan
authors.forename: Meltem Ceyhan
authors.initials: MC
authors.lastname: Bilgici
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dağdemir
authors.forename: Merve
authors.initials: M
authors.lastname: Korkmaz
authors.forename: Fevziye Canbaz
authors.initials: FC
authors.lastname: Tosun
mesh_terms: D000293:Adolescent; D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D010023:Osteopoikilosis / Q000000981:diagnostic imaging* / Q000628:therapy; D059408:Pain Management / Q000379:methods; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed