title: Structure of a cupin protein Plu4264 from Photorhabdus luminescens subsp. laumondii TTO1 at 1.35 Å resolution.
abstract: Proteins belonging to the cupin superfamily have a wide range of catalytic and noncatalytic functions. Cupin proteins commonly have the capacity to bind a metal ion with the metal frequently determining the function of the protein. We have been investigating the function of homologous cupin proteins that are conserved in more than 40 species of bacteria. To gain insights into the potential function of these proteins we have solved the structure of Plu4264 from Photorhabdus luminescens TTO1 at a resolution of 1.35 Å and identified manganese as the likely natural metal ligand of the protein.
authors.affiliation: Department of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin.
authors.forename: R Sophia
authors.initials: RS
authors.lastname: Weerth
authors.forename: Karolina
authors.initials: K
authors.lastname: Michalska
authors.forename: Craig A
authors.initials: CA
authors.lastname: Bingman
authors.forename: Ragothaman M
authors.initials: RM
authors.lastname: Yennamalli
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Robert
authors.initials: R
authors.lastname: Jedrzejczak
authors.forename: Fengbin
authors.initials: F
authors.lastname: Wang
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Babnigg
authors.forename: Andrzej
authors.initials: A
authors.lastname: Joachimiak
authors.forename: Michael G
authors.initials: MG
authors.lastname: Thomas
authors.forename: George N
authors.initials: GN
authors.lastname: Phillips
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D008345:Manganese / Q000737:chemistry; D008958:Models, Molecular; D020637:Photorhabdus / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D001426:Bacterial Proteins; D008345:Manganese
keywords: X-ray; cupin; manganese-bound; natural product; structural genomics