title: The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions.
abstract: A rapid flow synthesis of oxazolines and their oxidation to the corresponding oxazoles is reported. The oxazolines are prepared at room temperature in a stereospecific manner, with inversion of stereochemistry, from β-hydroxy amides using Deoxo-Fluor®. The corresponding oxazoles can then be obtained via a packed reactor containing commercial manganese dioxide.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. svl1000@cam.ac.uk.
authors.forename: Steffen
authors.initials: S
authors.lastname: Glöckner
authors.forename: Duc N
authors.initials: DN
authors.lastname: Tran
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Ingham
authors.forename: Sabine
authors.initials: S
authors.lastname: Fenner
authors.forename: Zoe E
authors.initials: ZE
authors.lastname: Wilson
authors.forename: Claudio
authors.initials: C
authors.lastname: Battilocchio
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000577:Amides / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D007700:Kinetics; D017895:Manganese Compounds / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry
chemical_list: D000577:Amides; D017895:Manganese Compounds; D010080:Oxazoles; D010087:Oxides; C027424:manganese oxide