title: The origin and significance of anti-DNA antibodies.
abstract: Polyreactive autoantibodies able to bind double-stranded DNA are a characteristic of systemic lucus erytheamtosus. Here, David Isenberg and Yehuda Shoenfeld discuss the likelihood that DNA is the immunogen in this disorder, and review a number of cross-reactions that may underline the detection of the antibodies.
authors.affiliation: The Bloomsbury Rheumatology Department, University College and The Middlesex Hospital Medical School, London, UK; The Department of Internal Medicine D and Research Units of Autoimmune Diseases, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: D
authors.initials: D
authors.lastname: Isenberg
authors.affiliation: The Bloomsbury Rheumatology Department, University College and The Middlesex Hospital Medical School, London, UK; The Department of Internal Medicine D and Research Units of Autoimmune Diseases, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Shoenfeld