title: Macular parameters of Stratus optical coherence tomography for assessing glaucoma in high myopia.
abstract: BACKGROUND
  The aim was to assess the macular parameters of glaucoma in highly myopic subjects.
  
  
  METHODS
  In a retrospective study, we enrolled 72 highly myopic eyes (spherical equivalent up to -6.00 D), of which 31 had early to moderate glaucoma and 41 formed a control group. The diagnosis of early to moderate glaucoma was based on glaucomatous visual-field defects with a mean deviation better than -12 dB. All patients underwent imaging with Stratus optical coherence tomography. We subsequently performed analysis for macular volume and thickness parameters between two groups.
  
  
  RESULTS
  Using Stratus optical coherence tomography, we found significantly lower values in both macular thickness and volume over outer superior, outer nasal, outer inferior, inner temporal and inner inferior regions in highly myopic eyes with early to moderate glaucoma than in the control group. The macular outer inferior average thickness, macular outer inferior average volume and total average macular volume on Stratus optical coherence tomography had a best combination of sensitivity and specificity (85.4 and 74.2 per cent, respectively). The outer inferior average volume and outer inferior average thickness parameters showed areas under the receiver operating characteristic curve value of 0.85 (95% CI 0.76 to 0.94), which were best for discriminating between early to moderate glaucoma and the control group.
  
  
  CONCLUSIONS
  Using Stratus optical coherence tomography, the outer inferior macular volume is the only independent predictor for detecting early to moderate glaucoma in high myopia. The macular outer inferior thickness and volume parameters showed good sensitivity, specificity and area under the receiver operating characteristic curve. These parameters may provide a complementary glaucomatous diagnosis in highly myopic eyes.
authors.affiliation: Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, ROC; Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Hung
authors.forename: Pei-Chang
authors.initials: PC
authors.lastname: Wu
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Ing-Chou
authors.initials: IC
authors.lastname: Lai
authors.forename: Jen-Chia
authors.initials: JC
authors.lastname: Tsai
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Lin
authors.forename: Mei-Ching
authors.initials: MC
authors.lastname: Teng
mesh_terms: D000328:Adult; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D009216:Myopia / Q000150:complications / Q000175:diagnosis*; D012372:ROC Curve; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*
keywords: glaucoma; high myopia; macula; optical coherence tomography