title: Broadband mesoscopic optoacoustic tomography reveals skin layers.
abstract: We have imaged for the first time to our knowledge human skin in vivo with a raster-scan optoacoustic mesoscopy system based on a spherically focused transducer with a central frequency of 102.8 MHz and large bandwidth (relative bandwidth 105%). Using tissue phantoms we have studied the ability of the system to image vessels of sizes within the anatomically significant range from the key anatomical vasculature sites. The reconstructed images from experiments in vivo show several structures from the capillary loops at the dermal papillae, the horizontal plexus, and the difference between the dermis and the epidermis layers.
authors.forename: Juan
authors.initials: J
authors.lastname: Aguirre
authors.forename: Mathias
authors.initials: M
authors.lastname: Schwarz
authors.forename: Dominik
authors.initials: D
authors.lastname: Soliman
authors.forename: Andreas
authors.initials: A
authors.lastname: Buehler
authors.forename: Murad
authors.initials: M
authors.lastname: Omar
authors.forename: Vasilis
authors.initials: V
authors.lastname: Ntziachristos
mesh_terms: D006801:Humans; D007091:Image Processing, Computer-Assisted; D061088:Photoacoustic Techniques; D012867:Skin / Q000166:cytology*; D014054:Tomography