title: CD8-positive peripheral T-cell lymphoma with aberrant expression of CD20 and concurrent in situ follicular lymphoma.
abstract: A case of a 78-year-old woman with a CD8-positive peripheral T-cell lymphoma with aberrant expression of CD20 associated with follicular lymphoma in situ (FLIS) is reported. The neoplasm presented initially as cutaneous macules, papules, plaques and nodules. A skin biopsy was performed and the diagnosis of peripheral T-cell lymphoma (PTCl) with aberrant expression of CD20 was made. The staging procedures included an excisional inguinal lymph node biopsy that showed findings similar to those of the previous diagnosis. In addition, FLIS was identified. The clinicopathologic features of PTCLs with aberrant CD20 expression involving the skin as well as this uncommon association are reviewed.
authors.affiliation: Hematopathology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain.
authors.forename: Amaia
authors.initials: A
authors.lastname: Sagasta
authors.forename: Ricardo
authors.initials: R
authors.lastname: Molina-Urra
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez
authors.forename: Blanca
authors.initials: B
authors.lastname: Gonzalez-Farre
authors.forename: Esther
authors.initials: E
authors.lastname: Marti
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Herranz
authors.forename: Teresa
authors.initials: T
authors.lastname: Estrach
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Lluis
authors.initials: L
authors.lastname: Colomo
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000096:biosynthesis*; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000378:metabolism / Q000473:pathology*; D016411:Lymphoma, T-Cell, Peripheral / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*
chemical_list: D018951:Antigens, CD20
keywords: CD20; FLIS; cutaneous T-cell lymphoma; follicular lymphoma