title: Noble gases as cardioprotectants - translatability and mechanism.
abstract: Several noble gases, although classified as inert substances, exert a tissue-protective effect in different experimental models when applied before organ ischaemia as an early or late preconditioning stimulus, after ischaemia as a post-conditioning stimulus or when given in combination before, during and/or after ischaemia. A wide range of organs can be protected by these inert substances, in particular cardiac and neuronal tissue. In this review we summarize the data on noble gas-induced cardioprotection, focusing on the underlying protective mechanisms. We will also look at translatability of experimental data to the clinical situation.
authors.affiliation: Department of Anaesthesiology, Laboratory of Experimental Intensive Care and Anaesthesiology (L.E.I.C.A), Academic Medical Centre (AMC), Amsterdam, The Netherlands.
authors.forename: Kirsten F
authors.initials: KF
authors.lastname: Smit
authors.forename: Nina C
authors.initials: NC
authors.lastname: Weber
authors.forename: Markus W
authors.initials: MW
authors.lastname: Hollmann
authors.forename: Benedikt
authors.initials: B
authors.lastname: Preckel
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006371:Helium / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D014978:Xenon / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D002316:Cardiotonic Agents; D006371:Helium; D014978:Xenon