title: Efficient synthesis of ethisterone glycoconjugate via bis-triazole linkage.
abstract: Synthesis of sugar based triazolyl azido-alcohols was accomplished via one pot click reaction of glycosyl alkynes with epichlorohydrin in aqueous medium. All the developed triazolyl azido-alcohols were further utilized for the synthesis of bis-triazolyl ethisterone glycoconjugates using CuAAC reaction. The developed triazole-linked ethisterone glycoconjugates would be crucial in androgen receptor pharmacology and chemical biology.
authors.affiliation: Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 5, India.
authors.forename: Kunj B
authors.initials: KB
authors.lastname: Mishra
authors.affiliation: Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 5, India.
authors.forename: Bhuwan B
authors.initials: BB
authors.lastname: Mishra
authors.affiliation: Department of Chemistry, Centre of Advanced Study, Faculty of Science, Banaras Hindu University, Varanasi 5, India. Electronic address: tiwari_chem@yahoo.co.in.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Tiwari
mesh_terms: D005003:Ethisterone / Q000138:chemical synthesis* / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry*; D008968:Molecular Conformation; D014230:Triazoles / Q000737:chemistry*
chemical_list: D006001:Glycoconjugates; D014230:Triazoles; D005003:Ethisterone
keywords: Carbohydrates; Click chemistry; Glycoconjugates; Steroids