title: Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype.
abstract: We describe a new atypical Shiga-toxin-producing Escherichia coli (STEC) responsible for a severe episode of haemolytic-uraemic syndrome in an adult with a relapse associated with bacteraemia. This STECs train of serotype O80:H2 harboured stx2c and stx2d gene subtypes, the rare eae ξ variant and a ColV plasmid with a conserved virulence plasmidic region involved in virulence of human and avian extraintestinal pathogenic E. coli. This atypical hybrid pathotype, which represents a new threat, is a further demonstration that STEC may be a recipient for extraintestinal virulence factors and raises again the question of antibiotic therapy during STEC infection.
authors.affiliation: Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Mariani-Kurkdjian
authors.affiliation: Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Lemaître
authors.affiliation: Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France ; IAME, UMR 1137, INSERM Paris, France ; IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Bidet
authors.affiliation: Service de Réanimation, Centre hospitalier de Lons-le-Saunier Lons-le-Saunier, France.
authors.forename: D
authors.initials: D
authors.lastname: Perez
authors.affiliation: Service de Microbiologie, Centre hospitalier de Lons-le-Saunier Lons-le-Saunier, France.
authors.forename: L
authors.initials: L
authors.lastname: Boggini
authors.affiliation: Service de Néphrologie, Hôpital Robert-Debré, AP-HP Paris, France.
authors.forename: T
authors.initials: T
authors.lastname: Kwon
authors.affiliation: Centre National de Référence associé Escherichia coli, Hôpital Robert-Debré, AP-HP Paris, France ; IAME, UMR 1137, INSERM Paris, France ; IAME, UMR 1137, Université Paris Diderot, Sorbonne Paris Cité Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Bonacorsi
keywords: ColV plasmid; Shiga toxin-producing Escherichia coli; bacteraemia; extraintestinal virulence factors; haemolytic–uraemic syndrome