title: Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats.
abstract: Hyperlipidemia is a well-established risk factor for the development of coronary atherosclerosis, while intermedin (IMD) has been identified as a novel calcitonin/calcitonin gene-related peptide family member involved in cardiovascular protection. However, whether IMD protects against hyperlipidemia-associated myocardial ischemia/reperfusion (MI/R) injury is unknown. We established a hyperlipidemia model using Sprague-Dawley rats, and created a MI/R condition by ligating the cardiac left circumflex artery. The possible pathophysiological role of IMD and its physiological function in MI/R was further studied. The level of IMD significantly decreased in hyperlipidemia rats (P < 0.05). After MI/R, the IMD level was increased both in the plasma and myocardial tissue of hyperlipidemia rats compared to the sham-operated rats (P < 0.001). As evaluated by the activity of LDH, CK-MB, MDA and SOD, additional IMD was revealed to alleviate MI/R heart injury in hyperlipidemia rats (P < 0.05). By regulating the process of cardiomyocyte apoptosis and inflammatory reaction, IMD could perform an important role in cardio-protection, especially against hyperlipidemia-associated MI/R injury. Additional IMD could protect cardiac myocytes against MI/R injury via reduction of apoptosis and inflammation in the hyperlipidemia rat model, and thus, it may play a potential role as a novel therapeutic target for cardiac ischemic injury in hyperlipidemic patients.
authors.affiliation: Department of Cardiac Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China smjlcn@163.com.
authors.forename: S M
authors.initials: SM
authors.lastname: Yang
authors.affiliation: Department of Library Management, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China.
authors.forename: J
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Cardiac Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, China.
authors.forename: C X
authors.initials: CX
authors.lastname: Li
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004195:Disease Models, Animal; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D018836:Inflammation Mediators / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D036361:Peptide Hormones / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats
chemical_list: D002316:Cardiotonic Agents; D018836:Inflammation Mediators; D008055:Lipids; D036361:Peptide Hormones; C561869:intermedin (17-47)