title: Functional evaluation of a CAD/CAM prosthesis for immediate defect repair after total maxillectomy: a case series of 18 patients with maxillary sinus cancer.
abstract: OBJECTIVE
  To evaluate the facial profiles and functional recovery of 18 patients treated by a computer-aided designed/manufactured hollow obturator prosthesis (CAD/CAM prosthesis) after total maxillectomy for malignant maxillary sinus tumor.
  
  
  METHODS
  A retrospective observational study was performed to evaluate the facial profiles and functional recovery of 18 patients with T3-4a N0 M0 maxillary sinus cancer, who were treated by total maxillectomy and simultaneous implantation of a computer-aided designed/manufactured hollow obturator prosthesis (CAD/CAM prosthesis). Follow-ups were performed 1, 3, 6, and 12 months after surgery. Facial measurements, speech intelligibility, and chewing and swallowing functions were examined. Thirteen patients converted to a permanent prosthesis 6 months after surgery. Comparisons were made between patients with and without the CAD/CAM or permanent prosthesis at various times using SPSS13.0 statistical software (SPSS Inc., Chicago, IL, USA).
  
  
  RESULTS
  Speech intelligibility, facial depression, and eyeball prolapse results showed improvements with prosthesis use at 1, 3, and 6 months after surgery (p < 0.05). Swallowing function improved from level V to level II-IV with prosthesis use at 1, 3, and 6 months, and reached level I or II with permanent prosthesis use at 12 months after surgery.
  
  
  CONCLUSIONS
  Simultaneous CAD/CAM prosthesis implantation recovered the facial profile, enhanced the speaking, swallowing, and chewing functions, and improved the quality of life of patients. Tumor recurrence can be detected by direct observation of the postoperative maxillary cavity. Therefore, this operation is recommended for simultaneous excision repair and functional reconstruction after total maxillectomy.
  
  
  CONCLUSIONS
  This surgical treatment of maxillary sinus cancer is applied rarely in China, but it has a good effect based on our observation. Simultaneous CAD/CAM prosthesis implantation after total maxillectomy can recover the facial profile, enhance the speaking, swallowing, and chewing functions, and improve the quality of life of patients. Tumor recurrence can be detected by direct observation of the postoperative maxillary cavity. This technique avoids the need for dental implants because the bottom part of the prosthesis contains a palatal plate with dentures.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, The First Hospital of China Medical University, Shenyang, 110001, Liaoning, China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Hou
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Xiao-Xu
authors.initials: XX
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Ai-Hui
authors.initials: AH
authors.lastname: Yan
mesh_terms: D017076:Computer-Aided Design; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000601:surgery*; D019736:Prostheses and Implants; D012189:Retrospective Studies