title: Increased expression of electron transport chain genes in uterine leiomyoma.
abstract: The etiology and pathophysiology of uterine leiomyomas, benign smooth muscle tumors of the uterus, are not well understood. To evaluate the role of mitochondria in uterine leiomyoma, we compared electron transport gene expressions of uterine leiomyoma tissue with myometrium tissue in six uterine leiomyoma patients by RT-PCR array. Our results showed an average of 1.562 (±0.445) fold increase in nuclear-encoded electron transport genes. These results might suggest an increase in size, number, or activity of mitochondria in uterine leiomyoma that, to our knowledge, has not been previously reported.
authors.affiliation: Department of Medical Biochemistry, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Akile
authors.initials: A
authors.lastname: Tuncal
authors.affiliation: Department of Medical Biochemistry, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Hikmet Hakan
authors.initials: HH
authors.lastname: Aydin
authors.affiliation: Department of Obstetrics & Gynecology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Niyazi
authors.initials: N
authors.lastname: Askar
authors.affiliation: Department of Medical Biochemistry, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Ali Burak
authors.initials: AB
authors.lastname: Ozkaya
authors.affiliation: Department of Obstetrics & Gynecology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Ahmet Mete
authors.initials: AM
authors.lastname: Ergenoglu
authors.affiliation: Department of Obstetrics & Gynecology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Ahmet Ozgur
authors.initials: AO
authors.lastname: Yeniel
authors.affiliation: Department of Obstetrics & Gynecology, Ege University Faculty of Medicine, Bornova, Izmir, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Akdemir
authors.affiliation: Department of Medical Biochemistry, Ege University Faculty of Medicine, Bornova, Izmir, Turkey handan.ak.c@gmail.com.
authors.forename: Handan
authors.initials: H
authors.lastname: Ak
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D025261:Mitochondrial Proton-Translocating ATPases / Q000235:genetics* / Q000378:metabolism; D009215:Myometrium / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D025261:Mitochondrial Proton-Translocating ATPases
keywords: Electron Transport System; Leiomyoma; Mitochondria; Oxidative Phosphorylation; Uterine Fibroid