title: Morin, a flavonoid, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats.
abstract: BACKGROUND
  Myocardial infarction affects a large population in the world. Lipid peroxide metabolism plays an important role in the pathology of myocardial infarction.
  
  
  OBJECTIVE
  The present study was designed to investigate the antioxidant potential of morin, a flavonoid in isoproterenol (ISO)-induced myocardial infarction (MI), in rats.
  
  
  METHODS
  Male albino Wistar rats were pre-treated with morin (40 mg/kg), daily for a period of 30 days. After the treatment period, ISO (85 mg/kg), was subcutaneously injected in rats at an interval of 24 h for 2 days.
  
  
  RESULTS
  ISO-administered rats showed elevated levels of thiobarbituric acid reactive substances (TBARS), and lipid hydro-peroxide (LOOH), in plasma and heart. Pretreatment with morin, the above changes were significantly reduced to near normal level. ISO-administered rats showed decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in heart. In addition, decrease the levels non enzymatic antioxidants such as reduced glutathione (GSH), vitamin C and vitamin E in plasma and heart while ceruloplasmin in plasma.
  
  
  CONCLUSIONS
  Pretreatment with morin, reversed these above biochemical changes towards normalcy. These findings revealed that, the morin possess antioxidant activity in experimentally induced cardiac toxicity.
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University. P.O. Box 10219, Riyadh 11433, Saudi Arabia.
authors.forename: Khalid S
authors.initials: KS
authors.lastname: Al-Numair
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University. P.O. Box 10219, Riyadh 11433, Saudi Arabia.
authors.forename: Govindasamy
authors.initials: G
authors.lastname: Chandramohan
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University. P.O. Box 10219, Riyadh 11433, Saudi Arabia.
authors.forename: Mohammed A
authors.initials: MA
authors.lastname: Alsaif
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University. P.O. Box 10219, Riyadh 11433, Saudi Arabia.
authors.forename: Chinnadurai
authors.initials: C
authors.lastname: Veeramani
authors.affiliation: Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University. P.O. Box 10219, Riyadh 11433, Saudi Arabia.
authors.forename: Ahmed S
authors.initials: AS
authors.lastname: El Newehy
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004195:Disease Models, Animal; D005419:Flavonoids / Q000008:administration & dosage*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D047309:Flavones
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D005978:Glutathione; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C008548:morin; D047309:Flavones
keywords: Antioxidants; Isoproterenol; Lipid peroxidation; Morin; Myocardial infarction