title: Oleic acid content of a meal promotes oleoylethanolamide response and reduces subsequent energy intake in humans.
abstract: Animal data suggest that dietary fat composition may influence endocannabinoid (EC) response and dietary behavior. This study tested the hypothesis that fatty acid composition of a meal can influence the short-term response of ECs and subsequent energy intake in humans. Fifteen volunteers on three occasions were randomly offered a meal containing 30 g of bread and 30 mL of one of three selected oils: sunflower oil (SO), high oleic sunflower oil (HOSO) and virgin olive oil (VOO). Plasma EC concentrations and appetite ratings over 2 h and energy intake over 24 h following the experimental meal were measured. Results showed that after HOSO and VOO consumption the circulating oleoylethanolamide (OEA) was significantly higher than after SO consumption; a concomitantly significant reduction of energy intake was found. For the first time the oleic acid content of a meal was demonstrated to increase the post-prandial response of circulating OEA and to reduce energy intake at subsequent meals in humans.
authors.affiliation: Department of Agricultural and Food Science, University of Naples Federico II, Portici (NA), Italy. paola.vitaglione@unina.it.
authors.forename: Ilario
authors.initials: I
authors.lastname: Mennella
authors.forename: Maria
authors.initials: M
authors.lastname: Savarese
authors.forename: Rosalia
authors.initials: R
authors.lastname: Ferracane
authors.forename: Raffaele
authors.initials: R
authors.lastname: Sacchi
authors.forename: Paola
authors.initials: P
authors.lastname: Vitaglione
mesh_terms: D000328:Adult; D000577:Amides; D001069:Appetite Regulation; D062408:Breakfast; D018592:Cross-Over Studies; D015930:Diet Records; D063388:Endocannabinoids / Q000097:blood*; D002149:Energy Intake; D004983:Ethanolamines / Q000097:blood; D005260:Female; D006801:Humans; D007558:Italy; D008041:Linoleic Acids / Q000097:blood; D008297:Male; D019301:Oleic Acid / Q000008:administration & dosage* / Q000032:analysis; D009829:Oleic Acids / Q000097:blood*; D000069463:Olive Oil; D010169:Palmitic Acids / Q000097:blood; D010938:Plant Oils / Q000737:chemistry*; D053284:Polyunsaturated Alkamides / Q000097:blood; D019518:Postprandial Period; D000074242:Sunflower Oil; D055815:Young Adult
chemical_list: D000577:Amides; D063388:Endocannabinoids; D004983:Ethanolamines; D008041:Linoleic Acids; D009829:Oleic Acids; D000069463:Olive Oil; D010169:Palmitic Acids; D010938:Plant Oils; D053284:Polyunsaturated Alkamides; D000074242:Sunflower Oil; C488250:oleoylethanolamide; D019301:Oleic Acid; C109347:linoleoyl ethanolamide; C005958:palmidrol