title: Corneal thickness differences between sexes after oxybuprocaine eye drops.
abstract: OBJECTIVE
  We aimed to analyze the corneal thickness (CT) values of female and male subjects before and after instillation of oxybuprocaine 0.4% anesthetic eye drops.
  
  
  METHODS
  The CT of 30 female subjects and 28 male subjects was measured using scanning-slit corneal topography (Orbscan Topography System II, Orbscan, Inc, Salt Lake City, UT). Measurements were carried out before and 3 minutes after the instillation of oxybuprocaine 0.4% eye drops.
  
  
  RESULTS
  The difference between the baseline values and those obtained after anesthesia ranged as follows: male subjects: central, -26 to +24 μm; superior, -24 to +23 μm; inferior, -19 to +20 μm; nasal, -25 to +30 μm; and temporal, -21 to +20 μm; female subjects: central, -16 to +24 μm; superior, -19 to +32 μm; inferior, -14 to +34 μm; nasal, -19 to +33 μm; and temporal, -36 to +16 μm. No significant differences were found in any corneal location in male subjects. The differences were significant at inferior (p = 0.001) and nasal (p = 0.011) corneal sites in female subjects.
  
  
  CONCLUSIONS
  Oxybuprocaine anesthetic eye drops induce significant CT increases in female subjects but not in male subjects.
authors.affiliation: *MSc †PhD ‡MD, PhD §OD, MSc Ocular Anatomy Unit, Department of Anatomy and Human Embryology, Faculty of Medicine (PF-G, LQ-G, JAS-G), and Optometry Research Group, Department of Optics (AC, CA-D, SG-L), University of Valencia, Valencia, Spain; and Pharmacology Unit, University Clinic Hospital, Valencia, Spain (PF-G).
authors.forename: Pablo
authors.initials: P
authors.lastname: Fernandez-Garcia
authors.forename: Alejandro
authors.initials: A
authors.lastname: Cerviño
authors.forename: Laura
authors.initials: L
authors.lastname: Quiles-Guiñau
authors.forename: Cesar
authors.initials: C
authors.lastname: Albarran-Diego
authors.forename: Santiago
authors.initials: S
authors.lastname: Garcia-Lazaro
authors.forename: Juan A
authors.initials: JA
authors.lastname: Sanchis-Gimeno
mesh_terms: D000293:Adolescent; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology*; D019781:Corneal Topography; D005260:Female; D006801:Humans; D008297:Male; D009883:Ophthalmic Solutions; D009929:Organ Size / Q000187:drug effects; D011343:Procaine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D011446:Prospective Studies; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D009883:Ophthalmic Solutions; D011343:Procaine; C005298:benoxinate