title: Comparative analysis of gene expression: uncovering expression conservation and divergence between Salmonella enterica serovar Typhimurium strains LT2 and 14028S.
abstract: Different strains of the same organism can share a large amount of their genetic material, the so called core pangenome. Nevertheless, these species can display different lifestyles and it is still not well known to what extent the core pangenome plays a role in the divergence of lifestyles between the two organisms. Here, we present a procedure for uncovering the conservation and divergence of gene expression by using large expression compendia. We will use data from two Salmonella enterica serovar Typhimurium strains as an example here, strain LT2 and strain 14028S, to assess if there are orthologous gene pairs with different expression domains related in both strains.
authors.affiliation: Department of Computational Biology, Fondazione Edmund Mach, San Michele all'Adige, Trento, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Sonego
authors.forename: Pieter
authors.initials: P
authors.lastname: Meysman
authors.forename: Marco
authors.initials: M
authors.lastname: Moretto
authors.forename: Roberto
authors.initials: R
authors.lastname: Viola
authors.forename: Kris
authors.initials: K
authors.lastname: Laukens
authors.forename: Duccio
authors.initials: D
authors.lastname: Cavalieri
authors.forename: Kristof
authors.initials: K
authors.lastname: Engelen
mesh_terms: D001483:Base Sequence; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D056510:Position-Specific Scoring Matrices; D012486:Salmonella typhimurium / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D012984:Software; D014774:Virulence