title: Urinary proteins with post-translational modifications.
abstract: Research on the human urine proteome may lay the foundation for the discovery of relevant disease biomarkers. Posttranslational modifications (PTMs) have important effects on the functions of protein biomarkers. Identifying PTMs without enrichment adds no extra steps to conventional identification procedures for urine proteomics. The only difference is that this method requires software that can conduct unrestrictive identifications of PTMs. These PTMs include methylation, dehydration, oxidation, hydroxylation, phosphorylation, or dihydroxylation. These data are useful reference for PTM biomarker discovery in the future.
authors.affiliation: Key Laboratory of Medical Molecular Biology, Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine, 5 Dong Dan San Tiao, Beijing, China, emma891021@hotmail.com.
authors.forename: Liu
authors.initials: L
authors.lastname: Liu
authors.forename: Xuejiao
authors.initials: X
authors.lastname: Liu
mesh_terms: D030562:Databases, Protein; D006801:Humans; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000378:metabolism*; D011507:Proteinuria / Q000652:urine*; D040901:Proteomics
chemical_list: D011506:Proteins