title: Neuronal MHC-I expression and its implications in synaptic function, axonal regeneration and Parkinson's and other brain diseases.
abstract: Neuronal expression of major histocompatibility complex I (MHC-I) has been implicated in developmental synaptic plasticity and axonal regeneration in the central nervous system (CNS), but recent findings demonstrate that constitutive neuronal MHC-I can also be involved in neurodegenerative diseases by playing a neuroinflammtory role. Recent reports demonstrate its expression in vitro and in human postmortem samples and support a role in neurodegeneration involving proinflammatory cytokines, activated microglia and increased cytosolic oxidative stress. Major histocompatibility complex I may be important for both normal development and pathogenesis of some CNS diseases including Parkinson's.
authors.affiliation: Department of Neurology, Columbia University Medical Center New York, NY, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Cebrián
authors.affiliation: Department of Physiology and Cellular Biophysics, Columbia University Medical Center New York, NY, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Loike
authors.affiliation: Department of Neurology, Columbia University Medical Center New York, NY, USA ; Departments of Psychiatry and Pharmacology, Columbia University Medical Center New York, NY, USA.
authors.forename: David
authors.initials: D
authors.lastname: Sulzer
keywords: major histocompatibility complex class I; neurodegeneration; neuroinflammation; neurons; plasticity