title: Cellular Membrane Microparticles: Potential Targets of Combinational Therapy for Vascular Disease.
abstract: Vascular disease constitutes the leading health problem throughout the entire world. Current therapies for vascular disease mainly rely on comprehensive strategies including control of risk factors, vascular interventions and conventional supportive treatments. To improve the preventive and therapeutic efficacies of current approaches, novel combinational therapies are required. Microparticles (MPs) are small membrane vesicles derived from cells undergoing stress, activation or apoptosis. They carry the characteristics of their parent cells, enabling them to serve as potential biomarkers for various diseases. Of note, MPs also have been shown to mediate cell communications through transferring membrane proteins, phospholipids and RNAs from their parent cells to recipient cells. Recent novel approaches have started to reveal the functions of MPs. In this review, we summarize the general concepts and the latest research progress in MPs. And the potential of MPs as novel targets of combinational therapy for vascular disease will be discussed.
authors.forename: Xiang
authors.initials: X
authors.lastname: Xiao
authors.forename: Xiaotang
authors.initials: X
authors.lastname: Ma
authors.forename: Langni
authors.initials: L
authors.lastname: Liu
authors.forename: Jinju
authors.initials: J
authors.lastname: Wang
authors.forename: Kexia
authors.initials: K
authors.lastname: Bi
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Fan
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Pharmacology & Toxicology, Wright State University, Boonshoft School of Medicine, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA. ji.bihl@wright.edu.
authors.forename: Ji C
authors.initials: JC
authors.lastname: Bihl
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology; D055252:Cell-Derived Microparticles / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003131:Combined Modality Therapy / Q000379:methods*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D012720:Severity of Illness Index; D014652:Vascular Diseases / Q000097:blood / Q000235:genetics / Q000473:pathology / Q000628:therapy*
chemical_list: D015415:Biomarkers