title: Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort.
abstract: BACKGROUND
  Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics.
  
  
  METHODS
  We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations.
  
  
  RESULTS
  We observed no association between IGF-I and EOC overall or by tumour characteristics.
  
  
  CONCLUSIONS
  In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Ose
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: R T
authors.initials: RT
authors.lastname: Fortner
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schock
authors.affiliation: Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: Peeters
authors.affiliation: Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 Utrecht, The Netherlands.
authors.forename: N C
authors.initials: NC
authors.lastname: Onland-Moret
authors.affiliation: 1] National Institute for Public Health and the Environment (RIVM), 3720 Bilthoven, The Netherlands [2] Department of Gastroenterology and Hepatology, University Medical Centre, 3542 Utrecht, The Netherlands [3] Department of Epidemiology and Statistics, the School of Public Health, Imperial College London, SW72AZ London, UK.
authors.forename: H B
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.affiliation: 1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 90109 Tromsø, Norway [2] Cancer Registry of Norway, 0304 Oslo, Norway [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden [4] Department of Genetic Epidemiology, Folkhälsan Research Center, 00014 Helsinki, Finland.
authors.forename: E
authors.initials: E
authors.lastname: Weiderpass
authors.affiliation: Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
authors.forename: I T
authors.initials: IT
authors.lastname: Gram
authors.affiliation: Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.
authors.forename: K
authors.initials: K
authors.lastname: Overvad
authors.affiliation: Institute of Cancer Epidemiology, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
authors.forename: A
authors.initials: A
authors.lastname: Tjonneland
authors.affiliation: 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France [3] IGR, F-94805 Villejuif, France.
authors.forename: L
authors.initials: L
authors.lastname: Dossus
authors.affiliation: 1] Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health team, F-94805 Villejuif, France [2] Univ Paris Sud, UMRS 1018, F-94805 Villejuif, France [3] IGR, F-94805 Villejuif, France.
authors.forename: A
authors.initials: A
authors.lastname: Fournier
authors.affiliation: 1] Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, 3004 Victoria, Australia [2] Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, 3004 Victoria, Australia.
authors.forename: L
authors.initials: L
authors.lastname: Baglietto
authors.affiliation: 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Trichopoulou
authors.affiliation: 1] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [2] Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, 75M Asias Street, Goudi, Athens GR-115 27, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Benetou
authors.affiliation: 1] Bureau of Epidemiologic Research, Academy of Athens, 23 Alexandroupoleos Street, Athens GR-115 27, Greece [2] Hellenic Health Foundation, 13 Kaisareias Street, Athens GR-115 27, Greece [3] Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
authors.forename: D
authors.initials: D
authors.lastname: Trichopoulos
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition (DIfE) 14558 Potsdam-Rehbrücke, Nuthetal, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Boeing
authors.affiliation: Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, 50139 Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Masala
authors.affiliation: Epidemiology and Prevention Unit, Fondazione IRCCS Instituto Nazionale dei Tumori, Via Veneziani 1, 20133 Milano, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Krogh
authors.affiliation: Department of Clinical and Experimental Medicine, Federico II University, 80131 Naples, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Matiello
authors.affiliation: Cancer Registry and Histopathology Unit, 'Civic - M.P. Arezzo' Hospita, ASP 97100 Ragusa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Tumino
authors.affiliation: Unit of Cancer Epidemiology, AO Citta' della Salute e della Scienza, Department of Medical Sciences, University of Turin and Center for Cancer Prevention (CPO-Piemonte), 10126 Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Popovic
authors.affiliation: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Obón-Santacana
authors.affiliation: 1] Public Health Division of Gipuzkoa-BIODonostia Research Institute, Basque Regional Health Department, 20013 San Sebastian, Spain [2] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Larrañaga
authors.affiliation: 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Navarre Public Health Institute, 31006 Pamplona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
authors.affiliation: 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Andalusian School of Public Health, 18011 Granada, Spain.
authors.forename: M-J
authors.initials: MJ
authors.lastname: Sánchez
authors.affiliation: Public Health Directorate, 33006 Asturias, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Menéndez
authors.affiliation: 1] Consortium for Biomedical Research in Epidemiology and Public Health (CIBER), 28029 Madrid, Spain [2] Department of Epidemiology, Murcia Regional Health Authority, 30008 Murcia, Spain.
authors.forename: M-D
authors.initials: MD
authors.lastname: Chirlaque
authors.affiliation: Cancer Epidemiology Unit, University of Oxford, OX30NR Oxford, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Travis
authors.affiliation: Department of Public Health and Primary Care, University of Cambridge, CB22QQ Cambridge, UK.
authors.forename: K-T
authors.initials: KT
authors.lastname: Khaw
authors.affiliation: Medical Department of Surgery, Malmö University Hospital, 20502 Malmö, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Brändstedt
authors.affiliation: Department of Clinical Sciences, Obstetrics and Gynecology and Department of Public Health and Clinical Medicine, Nutritional Research Umeå University, 90185 Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Idahl
authors.affiliation: Department of Medical Biosciences, Pathology Umeå University, 90185 Umeå, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Lundin
authors.affiliation: International Agency for Research on Cancer, 69372 Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Rinaldi
authors.affiliation: International Agency for Research on Cancer, 69372 Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Kuhn
authors.affiliation: International Agency for Research on Cancer, 69372 Lyon, France.
authors.forename: I
authors.initials: I
authors.lastname: Romieu
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW72AZ London, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Gunter
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW72AZ London, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Merritt
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, SW72AZ London, UK.
authors.forename: E
authors.initials: E
authors.lastname: Riboli
authors.affiliation: Division of Cancer Epidemiology, German Cancer Research Center, 69120 Heidelberg, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Kaaks
mesh_terms: D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D015331:Cohort Studies; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000453:epidemiology* / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000378:metabolism*; D011446:Prospective Studies; D012306:Risk
chemical_list: D007334:Insulin-Like Growth Factor I