title: Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris.
abstract: BACKGROUND
  Recent evidence demonstrated that the circulating adipokines were associated with the onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and acute myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis and the presence of coronary artery disease. However, the plasma levels of chemerin in patients with ACS have yet to be investigated.
  
  
  METHODS
  Plasma levels of chemerin and adiponectin were measured by an enzyme-linked immunosorbent assay (ELISA) in 60 patients with stable angina pectoris (SAP), 60 patients with UAP, 60 patients with AMI and 40 control patients. Left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were measured using a GE ViVid E7 ultrasonography machine, and the severity of coronary stenosis in patients was estimated with a Gensini coronary score following coronary angiography.
  
  
  RESULTS
  Plasma chemerin levels were significantly higher in ACS patients than in the control and SAP groups, while plasma adiponectin levels were significantly lower in ACS patients than the control group. A correlation analysis revealed that plasma chemerin levels were positively correlated with the levels of C-reactive protein (CRP) (r = 0.29, P < 0.01) and LVEDD (r = 0.27, P < 0.01) but negatively correlated with LVEF (r = -0.45, P < 0.01) and that plasma adiponectin levels were positively correlated with LVEF (r = 0.53, P < 0.01) but negatively correlated with CRP (r = -0.33, P < 0.01) and LVEDD (r = -0.30, P < 0.01). Although significant correlations between chemerin, adiponectin and BMI or the Gensini coronary score were found in patients with SAP, neither chemerin nor adiponectin was correlated with BMI and the Gensini coronary score in patients with ACS. Furthermore, both chemerin (OR 1.103, 95% CI 1.065 to 1.142; P = 0.001) and adiponectin (OR 0.871, 95% CI 0.776 to 0.970; P = 0.018) were independently associated with the presence of ACS.
  
  
  CONCLUSIONS
  Chemerin is a novel biomarker of acute coronary syndrome but not of stable angina pectoris.
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Ji
authors.forename: Yingzhong
authors.initials: Y
authors.lastname: Lin
authors.forename: Zhishan
authors.initials: Z
authors.lastname: Liang
authors.forename: Kunwu
authors.initials: K
authors.lastname: Yu
authors.forename: Yuyang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fang
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.forename: Qiutang
authors.initials: Q
authors.lastname: Zeng
authors.forename: Chao
authors.initials: C
authors.lastname: Chang
authors.forename: Meng
authors.initials: M
authors.lastname: Chai
authors.forename: Yujie
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000097:blood; D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human