title: Asymmetric hydrogenation via capture of active intermediates generated from aza-Pinacol rearrangement.
abstract: An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
authors.forename: Chang-Bin
authors.initials: CB
authors.lastname: Yu
authors.forename: Wen-Xue
authors.initials: WX
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
mesh_terms: D000588:Amines / Q000737:chemistry; D000605:Amino Alcohols / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D009842:Oligopeptides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000588:Amines; D000605:Amino Alcohols; D001372:Aza Compounds; D009842:Oligopeptides; C414027:aza-pinacol; D010165:Palladium