title: DNA-programmed dynamic assembly of quantum dots for molecular computation.
abstract: Despite the widespread use of quantum dots (QDs) for biosensing and bioimaging, QD-based bio-interfaceable and reconfigurable molecular computing systems have not yet been realized. DNA-programmed dynamic assembly of multi-color QDs is presented for the construction of a new class of fluorescence resonance energy transfer (FRET)-based QD computing systems. A complete set of seven elementary logic gates (OR, AND, NOR, NAND, INH, XOR, XNOR) are realized using a series of binary and ternary QD complexes operated by strand displacement reactions. The integration of different logic gates into a half-adder circuit for molecular computation is also demonstrated. This strategy is quite versatile and straightforward for logical operations and would pave the way for QD-biocomputing-based intelligent molecular diagnostics.
authors.affiliation: The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren'ai Road, Suzhou, 215123 (P.R. China).
authors.forename: Xuewen
authors.initials: X
authors.lastname: He
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Muzi
authors.initials: M
authors.lastname: Chen
authors.forename: Nan
authors.initials: N
authors.lastname: Ma
mesh_terms: D015374:Biosensing Techniques; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D031541:Fluorescence Resonance Energy Transfer; D046529:Microscopy, Electron, Transmission; D045663:Quantum Dots / Q000737:chemistry*
chemical_list: D004247:DNA
keywords: DNA; biocomputing; logic gates; molecular computation; quantum dots