title: [Phenotypes of bone and adipose tissue metabolism. A systematic review of their relationship].
abstract: BACKGROUND
  There is a central regulation of bone remodeling in the hypothalamus, a pathway that appears regulate the adipose tissue metabolism as well. The aim of the present review was to explore the evidence in literature on the relationships between bone mineral density and body composition phenotypes, leptin, adipose tissue and the insulin-glucose axis.
  
  
  METHODS
  A systematic search was conducted in electronic databases, in order to review publications addressing discussions on the link between bone mineral metabolism and adipose tissue integrative biology, published between January 2005 and November 2011.
  
  
  RESULTS
  Two hundred and sixty-two articles were reviewed, out of which 12 met strict inclusion criteria (methodological design, study population and information quality control). The results suggest that cardiovascular risk phenotypes of metabolic origin and body fat are correlated with bone turnover markers and bone mineral density. Osteoporosis and obesity are two pathologies classified as body composition alterations.
  
  
  CONCLUSIONS
  The literature review demonstrates that the fat-bone relationship involves common epidemiological, genetic and molecular aspects. These findings reflect the advances in the study of bone metabolism and adipose tissue.
authors.affiliation: Centro de Investigación en Nutrición y Salud Pública, Facultad de Salud Pública y Nutrición, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México. edna.navag@uanl.mx.
authors.forename: Edna J
authors.initials: EJ
authors.lastname: Nava-González
authors.forename: Esther C
authors.initials: EC
authors.lastname: Gallegos-Cabriales
authors.forename: Raúl A
authors.initials: RA
authors.lastname: Bastarrachea
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density; D016723:Bone Remodeling / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D009765:Obesity / Q000209:etiology / Q000378:metabolism*; D010024:Osteoporosis / Q000209:etiology / Q000378:metabolism*; D010641:Phenotype
chemical_list: D015415:Biomarkers; D007328:Insulin; D020738:Leptin; D005947:Glucose
keywords: Adipose tissue; Body composition; Bone density; Obesity; Osteoporosis