title: Rationale for Using Exercise in the Treatment of Stimulant Use Disorders.
abstract: Novel approaches to the treatment of stimulant abuse and dependence are needed. Clinical data examining the use of exercise as a treatment for the abuse of nicotine, alcohol, and other substances suggest that exercise may be a beneficial treatment for stimulant abuse. In addition, exercise has been associated with improvements in many other health-related areas that may be adversely affected by stimulant use or its treatment, such as sleep disturbance, cognitive function, mood, weight, quality of life, and anhedonia. Neurobiological evidence provides plausible mechanisms by which exercise could positively affect treatment outcomes in stimulant abuse. The National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) CTN-0037 Stimulant Reduction Intervention using Dosed Exercise (STRIDE) study is a multisite randomized clinical trial that compares exercise to health education as potential treatments for stimulant abuse or dependence. If effective, exercise may provide an additional approach to the treatment of stimulant use disorders.
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Tracy L
authors.initials: TL
authors.lastname: Greer
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Kolette M
authors.initials: KM
authors.lastname: Ring
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Diane
authors.initials: D
authors.lastname: Warden
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Grannemann
authors.affiliation: Preventive Medicine Laboratory, Pennington Biomedical Research Center.
authors.forename: Timothy S
authors.initials: TS
authors.lastname: Church
authors.affiliation: Cincinnati Addictions Research Center (CinARC); Department of Psychiatry, University of Cincinnati College of Medicine.
authors.forename: Eugene
authors.initials: E
authors.lastname: Somoza
authors.affiliation: Department of Exercise Science, University of South Carolina ; Department of Epidemiology and Biostatistics, University of South Carolina.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Blair
authors.affiliation: Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine.
authors.forename: Jose
authors.initials: J
authors.lastname: Szapocznik
authors.affiliation: Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine.
authors.forename: Mark
authors.initials: M
authors.lastname: Stoutenberg
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Chad
authors.initials: C
authors.lastname: Rethorst
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Robrina
authors.initials: R
authors.lastname: Walker
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: David W
authors.initials: DW
authors.lastname: Morris
authors.affiliation: Department of Biostatistics and Bioinformatics, Duke University Medical Center, Duke Clinical Research Institute.
authors.forename: Andrzej S
authors.initials: AS
authors.lastname: Kosinski
authors.affiliation: The Center for Drug-Free Living.
authors.forename: Tiffany
authors.initials: T
authors.lastname: Kyle
authors.affiliation: Department of Family and Preventive Medicine, The University of California, San Diego.
authors.forename: Bess
authors.initials: B
authors.lastname: Marcus
authors.affiliation: Nexus Recovery Center, Inc.
authors.forename: Becca
authors.initials: B
authors.lastname: Crowell
authors.affiliation: The EMMES Corporation.
authors.forename: Neal
authors.initials: N
authors.lastname: Oden
authors.affiliation: New York State Psychiatric Institute/Department of Psychiatry, College of Physicians and Surgeons of Columbia University.
authors.forename: Edward
authors.initials: E
authors.lastname: Nunes
authors.affiliation: The University of Texas Southwestern Medical Center at Dallas.
authors.forename: Madhukar H
authors.initials: MH
authors.lastname: Trivedi
keywords: behavioral intervention; exercise; health education; stimulant abuse; stimulant dependence