title: Individually tailored screening of susceptibility to sarcopenia using p53 codon 72 polymorphism, phenotypes, and conventional risk factors.
abstract: OBJECTIVE
  p53 activity plays a role in muscle homeostasis and skeletal muscle differentiation; all pathways that lead to sarcopenia are related to p53 activities. We investigate the allelic frequency of the TP53 codon 72 in exon 4 polymorphism in the Italian female population and the association with appendicular skeletal muscle mass index in normal weight (NW), normal weight obese (NWO), and preobese-obese (Preob-Ob) subjects.
  
  
  METHODS
  We evaluated anthropometry, body composition, and p53 polymorphism in 140 women distinguished in NW, NWO, and Preob-Ob.
  
  
  RESULTS
  *Arg/*Arg genotype increases sarcopenia risk up to 20% (*Arg/*Arg genotype OR = 1.20; 95% CI = 0.48-2.9; *proallele carriers OR = 0.83; 95% CI = 0.83-2.06). The risk of being sarcopenic for *Arg/*Arg genotype in NWO and Preob-Ob is 31% higher than NW carriers of *proallele (RR = 0,31, 95% CI = 0,15-0,66, P = 0,0079). We developed a model able to predict sarcopenia risk based on age, body fat, and p53 polymorphism.
  
  
  CONCLUSIONS
  Our study evidences that genotyping TP53 polymorphism could be a useful new genetic approach, in association with body composition evaluations, to assess sarcopenia risk.
authors.affiliation: Department of Biomedicine and Prevention, Division of Clinical Nutrition and Nutrigenomics, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy ; Nuova Clinica Annunziatella, 00147 Roma, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Di Renzo
authors.affiliation: Department of Surgery and Medical Science, University "Magna Graecia", 88100 Germaneto, Italy.
authors.forename: Santo
authors.initials: S
authors.lastname: Gratteri
authors.affiliation: Department of Agriculture, University of Naples "Federico II", 80055 Portici, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Sarlo
authors.affiliation: Department of Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Andrea
authors.identifier: 0000-0002-9161-6681
authors.initials: A
authors.lastname: Cabibbo
authors.affiliation: CNR, ISN UOS of Pharmacology, Department of Pharmacology, University "Magna Graecia", 88100 Roccelletta di Borgia, Italy.
authors.forename: Carmen
authors.initials: C
authors.lastname: Colica
authors.affiliation: Department of Biomedicine and Prevention, Division of Clinical Nutrition and Nutrigenomics, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy ; Nuova Clinica Annunziatella, 00147 Roma, Italy ; National Institute for Mediterranean Diet and Nutrigenomics (I.N.Di.M.), 87032 Amantea, Italy.
authors.forename: Antonino
authors.identifier: 0000-0001-6524-4493
authors.initials: A
authors.lastname: De Lorenzo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001835:Body Weight; D003062:Codon; D005260:Female; D006801:Humans; D008875:Middle Aged; D008957:Models, Genetic; D009765:Obesity / Q000150:complications; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D055948:Sarcopenia / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53