title: Beneficial impact of sleep extension on fasting insulin sensitivity in adults with habitual sleep restriction.
abstract: OBJECTIVE
  A link between sleep loss and increased risk for the development of diabetes is now well recognized. The current study investigates whether sleep extension under real-life conditions is a feasible intervention with a beneficial impact on glucose metabolism in healthy adults who are chronically sleep restricted.
  
  
  METHODS
  Intervention study.
  
  
  METHODS
  Sixteen healthy non-obese volunteers (25 [23, 27.8] years old, 3 men).
  
  
  METHODS
  Two weeks of habitual time in bed followed by 6 weeks during which participants were instructed to increase their time in bed by one hour per day.
  
  
  RESULTS
  Continuous actigraphy monitoring and daily sleep logs during the entire study. Glucose and insulin were assayed on a single morning blood sample at the end of habitual time in bed and at the end of sleep extension. Home polysomnography was performed during one weekday of habitual time in bed and after 40 days of sleep extension. Sleep time during weekdays increased (mean actigraphic data: +44 ± 34 minutes, P < 0.0001; polysomnographic data: +49 ± 68 minutes, P = 0.014), without any significant change during weekends. Changes from habitual time in bed to the end of the intervention in total sleep time correlated with changes in glucose (r = +0.53, P = 0.041) and insulin levels (r = -0.60, P = 0.025), as well as with indices of insulin sensitivity (r = +0.76, P = 0.002).
  
  
  CONCLUSIONS
  In healthy adults who are chronically sleep restricted, a simple low cost intervention such as sleep extension is feasible and is associated with improvements in fasting insulin sensitivity.
authors.affiliation: Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Rachel
authors.initials: R
authors.lastname: Leproult
authors.affiliation: Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium.|CO3-Consciousness, Cognition & Computation Group, Center for Research in Cognition and Neurosciences and the ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Gaétane
authors.initials: G
authors.lastname: Deliens
authors.affiliation: Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Médhi
authors.initials: M
authors.lastname: Gilson
authors.affiliation: Neuropsychology and Functional Neuroimaging Research Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium.
authors.forename: Philippe
authors.initials: P
authors.lastname: Peigneux
mesh_terms: D056044:Actigraphy; D000328:Adult; D001835:Body Weight; D002908:Chronic Disease; D005215:Fasting / Q000502:physiology*; D005260:Female; D005947:Glucose / Q000032:analysis / Q000378:metabolism; D064368:Healthy Volunteers; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors; D055815:Young Adult
chemical_list: D007328:Insulin; D005947:Glucose
keywords: QUICKI; fasting glucose; fasting insulin; insulin resistance; insulin sensitivity; sleep extension; sleep loss; time in bed; type 2 diabetes