title: Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii.
abstract: A new alkaloid, adlumiceine methyl ester (1), together with two known alkaloids, parfumine (2) and N-methylhydrastine methyl ester (3), was isolated from aerial parts of Fumaria vaillantii. The structures of compounds were determined by 1D/2D NMR and MS data. All three compounds were tested for cytotoxic activity against PC3 and MCF7 cell lines using Alamar blue assay. The tested compounds showed no significant cytotoxic activity (IC50>50 μM) against PC3 and MCF7 cell lines.
authors.affiliation: a Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences , Mashhad , Iran.
authors.forename: Milad
authors.initials: M
authors.lastname: Iranshahy
authors.forename: Hamideh
authors.initials: H
authors.lastname: Javidi-Shirazi
authors.forename: Ngoc B
authors.initials: NB
authors.lastname: Pham
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
authors.forename: Hamid
authors.initials: H
authors.lastname: Sadeghian
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Iranshahi
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D005260:Female; D031312:Fumaria / Q000737:chemistry*; D006801:Humans; D007492:Iran; D061986:MCF-7 Cells; D015394:Molecular Structure; D009665:Noscapine / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D004952:Esters; C000595812:adlumiceine methyl ester; D009665:Noscapine
keywords: Fumaria; N-methylhydrastine methyl ester; Papaveraceae; alkaloids; parfumine