title: Plasma β-amyloid and MRI markers of cerebral small vessel disease: Three-City Dijon study.
abstract: OBJECTIVE
  We investigated the relation of circulating plasma β-amyloid (Aβ) with MRI markers of small vessel disease (SVD) in dementia-free community persons.
  
  
  METHODS
  Participants were 1,690 individuals aged 65 to 80 years from the Three-City Dijon Study. Plasma Aβ measurement and MRI examination were performed at baseline and after a 4-year follow-up. MRI markers of SVD included white matter hyperintensities (WMH), lacunes, and enlarged perivascular spaces. We examined the relation of plasma Aβ levels with MRI markers of SVD at baseline and with progression of WMH over follow-up (n = 1,057). We also assessed whether these relations were modified by vascular risk factors, notably blood pressure.
  
  
  RESULTS
  Low plasma Aβ1-40 levels were associated with increased progression of WMH, and low Aβ1-42 with higher odds of extensive WMH progression over the follow-up (odds ratio = 1.66, 95% confidence interval = 1.16-2.38). Consistently low Aβ1-40 and Aβ1-42 levels on both measurements were associated with accelerated progression of WMH. These associations were modified by blood pressure levels but not the APOE ε4 genotype.
  
  
  CONCLUSIONS
  Progression of WMH volume in dementia-free older persons is associated with levels of circulating plasma Aβ. These results reinforce the notion of an interrelation of vascular and neurodegenerative mechanisms in cerebral aging.
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA. sara.kaffashian@inserm.fr.
authors.forename: Sara
authors.initials: S
authors.lastname: Kaffashian
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Aïcha
authors.initials: A
authors.lastname: Soumaré
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Carole
authors.initials: C
authors.lastname: Dufouil
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Zhu
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Crivello
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Pauline
authors.initials: P
authors.lastname: Maillard
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Susanna
authors.initials: S
authors.lastname: Schraen-Maschke
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Bernard
authors.initials: B
authors.lastname: Mazoyer
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Luc
authors.initials: L
authors.lastname: Buée
authors.affiliation: From INSERM U897 (S.K., C.T., A.S., C.D., Y.Z., S.D.), University of Bordeaux, France; Peking Union Medical College Hospital (Y.Z.), Beijing, China; CNRS-CEA UMR 5296 (F.C., B.M.), University of Bordeaux, France; University of California Davis (P.M.); CHRU de Lille (S.S.-M., L.B.), Lille, France; INSERM U837 (S.S.-M., L.B.), Lille, France; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Boston University School of Medicine, Framingham Heart Study, Boston, MA.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Debette
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D059345:Cerebral Small Vessel Diseases / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000639:trends*; D008297:Male; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)