title: Bifocal juvenile papillomatosis as a marker of breast cancer: A case report and review of the literature.
abstract: Juvenile papillomatosis (JP), also termed Swiss cheese disease, is a rare and benign type of proliferative breast tumor that is specifically observed in children and adolescents. The majority of JP patients are Caucasian and exhibit a single breast mass. The current report presents an unusual case of bifocal JP in an 11-year-old Chinese female. The patient presented with a slow-growing palpable mass in the upper outer quadrant of the left breast. Ultrasonography identified a further impalpable lesion in the lower outer quadrant of the ipsilateral breast. The preoperative clinical diagnosis of the two masses was fibroadenoma, however, following complete excision of the two tumors, histopathology revealed JP. Furthermore, the patient had a family history of breast cancer. The current report describes a review of the literature regarding the presentation, pathology, diagnosis, and treatment of JP and its association with breast carcinoma. In the current case, JP was associated with an increased risk of breast cancer in the patient, as well as the patient's elder female relatives; therefore, a more thorough medical follow-up may prove prudent for those individuals with a high risk of developing breast cancer.
authors.affiliation: Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China.
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Breast Cancer Pathology and Research Laboratory, National Clinical Research Center for Cancer, Key Laboratories of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China.
authors.forename: Ya-Qing
authors.initials: YQ
authors.lastname: Li
authors.affiliation: Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Breast Cancer Pathology and Research Laboratory, National Clinical Research Center for Cancer, Key Laboratories of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China.
authors.forename: Xi-Lin
authors.initials: XL
authors.lastname: Fu
authors.affiliation: Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China ; Division of Hematology and Oncology, Georgia Regents University Cancer Center, Augusta, GA 30912, USA.
authors.forename: Shou-Ching
authors.initials: SC
authors.lastname: Tang
keywords: breast cancer risk; diagnosis and treatment; juvenile papillomatosis