title: Sperm dynamics in tubular confinement.
abstract: An on-chip system that mimics tubular microenvironments is presented for the study of spermatozoa motion in confinement. Using rolled up transparent silicon oxide/dioxide microtubes, the influence of tube diameter on the velocity, directionality, and linearity of spermatozoa is investigated. Tubular microenvironments of diameters 20-45 μm facilitate sperm migration through channels.
authors.affiliation: Institute for Integrative Nanosciences, Leibniz Institute for Solid State and Materials Research, Helmholtzstr. 20, 01069, Dresden, Germany.
authors.forename: Veronika
authors.initials: V
authors.lastname: Magdanz
authors.forename: Britta
authors.initials: B
authors.lastname: Koch
authors.forename: Samuel
authors.initials: S
authors.lastname: Sanchez
authors.forename: Oliver G
authors.initials: OG
authors.lastname: Schmidt
mesh_terms: D000818:Animals; D002417:Cattle; D060833:Cellular Microenvironment; D008297:Male; D012822:Silicon Dioxide / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
chemical_list: D012822:Silicon Dioxide
keywords: microchannels; microtubes; motile cells; spacial confinement; sperm migration