title: TNM and Modified Dukes staging along with the demographic characteristics of patients with colorectal carcinoma.
abstract: OBJECTIVE
  Colon adenocarcinoma, is the most common cancer in gastrointesinal system (GIS). The whole world is an important cause of morbidity and mortality. TNM and modified Dukes classification which has great importance in the diagnosis and treatment of Colorectal cancer (CRC). TNM and Modified Dukes classification results of histopathological examination and the demographic characteristics of patients and their relation were investigated.
  
  
  METHODS
  Lower gastrointestinal operation results of 85 patients were examined accepted to clinical Pathology between January 1997-November 2013. Colon cancer had been diagnosed at 85 patients with pathology materials and staging was done according to the TNM and Modified Duke classification. The demographic characteristics of patients, differentiation grade, lymph node involvement, serous involvement were evaluated retrospectively.
  
  
  RESULTS
  In this study 37 patients (43.52%) were men and 48 (56.47%) were women. Ages of patients were between 19 and 87 with a mean age of 57.31 ± 15.31. Lymph node, differentiation, serosa involvement, Modified Dukes and TNM classification was assessed according to sex and age. TNM classification by sex was not statistically significant (p > 0.05). There was no statistically significant relationship between age and differentiation (p = 0.085). Value of differentiation increased towards from 1 to 3 inversely proportional to age. So young patients defined as well-differentiated at the conclusion. Negative relationship was evaluated between age and TNM Class variables. As a result, the relationship between age and TNM was not significant (p > 0.05). However, with increasing age the degree of staging was also found to increase. TNM classification was associated with the differentiation and it was significant (p = 0.043).
  
  
  CONCLUSIONS
  Colon cancer, when contracted at an early stage, it is suitable for surgery and curative treatment can be done with minimal morbidity and mortality. However, some of the patients have advanced disease at diagnosis and their 5-year survival rate is only 8%. Every year there is prolongation of overall survival of colon cancer. It is so common cancer type so that determination of prognostic factors, disease staging and treatment strategy which affects survival is significant.
authors.affiliation: Department of Family Medicine, İskenderun State Hospital Hatay.
authors.forename: Ayşe Neslin
authors.initials: AN
authors.lastname: Akkoca
authors.affiliation: Department of Patology, İskenderun State Hospital Hatay.
authors.forename: Serdar
authors.initials: S
authors.lastname: Yanık
authors.affiliation: Department of Internal Medicine, Bozok University Medical School Yozgat.
authors.forename: Zeynep Tuğba
authors.initials: ZT
authors.lastname: Ozdemir
authors.affiliation: Department of Family Medicine, Meram Medical School, Necmettin Erbakan University Konya.
authors.forename: Fatma Gökşin
authors.initials: FG
authors.lastname: Cihan
authors.affiliation: Department of Gastroenterology, Dr. Ersin Arslan State Hospital Gaziantep.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Sayar
authors.affiliation: Department of General Surgeon, İskenderun State Hospital Hatay.
authors.forename: Tarık Gandi
authors.initials: TG
authors.lastname: Cincin
authors.affiliation: Department of Internal Medicine, İskenderun State Hospital Hatay.
authors.forename: Akın
authors.initials: A
authors.lastname: Cam
authors.affiliation: Department of Family Medicine, Mustafa Kemal University Medical School Hatay.
authors.forename: Cahit
authors.initials: C
authors.lastname: Ozer
keywords: Gastrointesinal system (GIS); Modified Dukes staging; TNM; colorectal cancer (CRC)