title: Molecular mechanisms and functional implications of polarized actin remodeling at the T cell immunological synapse.
abstract: Transient,specialized cell-cell interactions play a central role in leukocyte function by enabling specific intercellular communication in the context of a highly dynamic systems level response. The dramatic structural changes required for the formation of these contacts are driven by rapid and precise cytoskeletal remodeling events. In recent years, the immunological synapse that forms between a T lymphocyte and its antigen-presenting target cell has emerged as an important model system for understanding immune cell interactions. In this review, we discuss how regulators of the cortical actin cytoskeleton control synaptic architecture and in this way specify T cell function.
authors.affiliation: Immunology Program, Memorial Sloan-Kettering Cancer Center, Box 514, 1275 York Ave, New York, NY, 10065, USA.
authors.forename: Audrey
authors.initials: A
authors.lastname: Le Floc'h
authors.affiliation: Immunology Program, Memorial Sloan-Kettering Cancer Center, Box 514, 1275 York Ave, New York, NY, 10065, USA. husem@mskcc.org.
authors.forename: Morgan
authors.initials: M
authors.lastname: Huse
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism; D002450:Cell Communication / Q000276:immunology*; D006801:Humans; D054992:Immunological Synapses / Q000276:immunology*; D018448:Models, Immunological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D020741:rho GTP-Binding Proteins / Q000378:metabolism
chemical_list: D000199:Actins; D019869:Phosphatidylinositol 3-Kinases; D020741:rho GTP-Binding Proteins