title: Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy.
abstract: Treatments of the post-operative surgical bed have proven appealing as the majority of cancer recurrence following tumor resection occurs at the tumor margin. A novel, biodegradable pullulan-based gel infused with magnetic iron oxide nanoparticles (IONP) is presented here for surgical bed administration followed by hyperthermia therapy via alternating magnetic field (AMF) activation. Pullulan is a water soluble, film-forming starch polymer that degrades at the postoperative wound site to deliver the IONP payload, targeting the remaining cancer cells. Different gel formulations containing various % wt of pullulan were tested for IONP elution. Elution levels and amount of gel degradation were measured by immersing the gel in de-ionized water for one hour then measuring particle concentrations in the supernatant and the mass of the remaining gel formulation. The most promising gel formulations will be tested in a murine model of surgical bed resection to assessin vivogel dissolution, IONP cell uptake kinetics via histology and TEM analysis, and heating capability of the gel with AMF exposure.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.
authors.forename: Bp
authors.initials: B
authors.lastname: Cunkelman
authors.affiliation: Geisel School of Medicine, Dartmouth College, Hanover, NH 03755 USA ; Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 USA.
authors.forename: Ey
authors.initials: E
authors.lastname: Chen
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.
authors.forename: Aa
authors.initials: A
authors.lastname: Petryk
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.
authors.forename: Ja
authors.initials: J
authors.lastname: Tate
authors.affiliation: Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 USA.
authors.forename: Sg
authors.initials: S
authors.lastname: Thappa
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA.
authors.forename: Rj
authors.initials: R
authors.lastname: Collier
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755 USA ; Geisel School of Medicine, Dartmouth College, Hanover, NH 03755 USA ; Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756 USA.
authors.forename: Pj
authors.initials: P
authors.lastname: Hoopes
keywords: biodegradable; cancer; gel; hyperthermia; iron oxide nanoparticles (IONP); surgical bed