title: Multiresidue analysis of pesticides in urine of healthy adult companion dogs.
abstract: The objective of this study was to determine the background exposures to pesticides as detected in urine from 21 healthy companion dogs in Northern Colorado. A panel of 301 pesticides was used to screen urine samples collected from dogs using an established ultraperformance liquid chromatography-mass spectrometry (UPLC-MS/MS) platform. Canine food intakes were controlled for one month on diets that were also screened for pesticide contents. Fifteen distinct pesticides were detected in urine. The most frequently detected compounds in canine urine samples collected over a 1 month period were atrazine, fuberidazole, imidacloprid, terbumeton, and clopyralid. Fuberidazole was the only pesticide detected in both the diets and urine. Companion dogs develop many similar chronic diseases as humans and represent a relevant model for biomonitoring combinations of environmental pesticide exposures, as well as for evaluating the potential relationships between environmental exposures and disease risk.
authors.affiliation: Department of Clinical Sciences and ‡Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University , 1680 Campus Delivery, Fort Collins, Colorado 80523-1680, United States.
authors.forename: Genevieve M
authors.initials: GM
authors.lastname: Forster
authors.forename: Dustin G
authors.initials: DG
authors.lastname: Brown
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Dooley
authors.forename: Rodney L
authors.initials: RL
authors.lastname: Page
authors.forename: Elizabeth P
authors.initials: EP
authors.lastname: Ryan
mesh_terms: D000818:Animals; D001280:Atrazine / Q000652:urine; D001562:Benzimidazoles / Q000032:analysis / Q000652:urine; D002853:Chromatography, Liquid / Q000379:methods; D003120:Colorado; D004285:Dogs; D004435:Eating; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D008297:Male; D013058:Mass Spectrometry; D010575:Pesticides / Q000032:analysis / Q000652:urine*; D057805:Pets / Q000652:urine; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D001562:Benzimidazoles; D010575:Pesticides; D001280:Atrazine; C004198:fuberidazole