Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children.
The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.
From the *Division of Pediatric Respiratory Medicine, University Children's Hospital, Bern, Switzerland; †Department of Pediatrics, "Sapienza" University of Rome, Rome, Italy; ‡Institute for Infectious Diseases, University of Bern, Bern; §Central Laboratory of Virology, University Hospitals of Geneva, Geneva; and ¶Department of Clinical Research, University of Bern, Bern, Switzerland.
Giulia
G
Cangiano
Elena
E
Proietti
Marie Noelle
MN
Kronig
Elisabeth
E
Kieninger
Christine D
CD
Sadeghi
Meri
M
Gorgievski
Maria Teresa
MT
Barbani
Fabio
F
Midulla
Caroline
C
Tapparel
Laurent
L
Kaiser
Marco P
MP
Alves
Nicolas
N
Regamey
D015415:Biomarkers / Q000032:analysis*; D001991:Bronchitis / Q000175:diagnosis* / Q000473:pathology; D002675:Child, Preschool; D016207:Cytokines / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008297:Male; D009297:Nasal Mucosa / Q000737:chemistry*; D010850:Picornaviridae Infections / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies; D012229:Rhinovirus / Q000302:isolation & purification; D012720:Severity of Illness Index; D019562:Viral Load
D015415:Biomarkers; D016207:Cytokines; D007770:L-Lactate Dehydrogenase