Late-stage [18F]Fluorination: New Solutions to Old Problems.
The last 2-3 years have seen numerous relationships develop between organometallic chemists, fluorine chemists and PET Centers around the world. These collaborations have led to the development of many new strategies for the late-stage introduction of fluorine-18 into complex bioactive molecules. In this perspective we highlight recent developments and key milestones since 2011.
Department of Radiology, The University of Michigan Medical School Ann Arbor MI, USA.
Allen F
AF
Brooks
Department of Chemistry, The University of Michigan, Ann Arbor MI, USA.
Joseph J
JJ
Topczewski
Department of Chemistry, The University of Michigan, Ann Arbor MI, USA.
Naoko
N
Ichiishi
Department of Chemistry, The University of Michigan, Ann Arbor MI, USA.
Melanie S
MS
Sanford
Department of Radiology, The University of Michigan Medical School Ann Arbor MI, USA ; The Interdepartmental Program in Medicinal Chemistry The University of Michigan, Ann Arbor MI, USA.
Peter J H
PJ
Scott