Placebo cessation in binge eating disorder: effect on anthropometric, cardiovascular, and metabolic variables.
OBJECTIVE
The aim of this study was to evaluate the effects of cessation of binge eating in response to placebo treatment in binge eating disorder (BED) on anthropometric, cardiovascular, and metabolic variables.


METHODS
We pooled participant-level data from 10 randomized, double-blind, placebo-controlled trials of medication for BED. We then compared patients who stopped binge eating with those who did not on changes in weight, body mass index (BMI), systolic and diastolic blood pressure, pulse, and fasting lipids and glucose.


RESULTS
Of 234 participants receiving placebo, 60 (26%) attained cessation from binge eating. Patients attaining cessation showed modestly decreased diastolic blood pressure compared with patients who continued to binge eat. Weight and BMI remained stable in patients who stopped binge eating, but increased somewhat in those who continued to binge eat.


CONCLUSIONS
Patients who stopped binge eating with placebo had greater reductions in diastolic blood pressure and gained less weight than patients who continued to binge eat. Self-report of eating pathology in BED may predict physiologic variables. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.
Lindner Center of HOPE, Mason, OH, USA; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Thomas J
TJ
Blom
Anna I
AI
Guerdjikova
Nicole
N
Mori
Leah S
LS
Casuto
Susan L
SL
McElroy
D000328:Adult; D056912:Binge-Eating Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
binge eating disorder; clinical; placebo response; trial; weight change