Losartan-induced Ischemic Hepatocellular Hepatotoxicity: A Case Report and Literature Review.
With the increasing use of various medications and supplements nowadays, the incidence of abnormal liver function tests and frank hepatic injury is has been increasing. Medications are now considered one of the most common causes of acute hepatic failure in the United States. Losartan was the first angiotensin 1 (AT1) receptor blocker approved by FDA for the treatment of arterial hypertension. It is a well-tolerated medication with few significant adverse effects. However, losartan-related hepatotoxicity has been reported rarely. We report a case of acute hepatic injury in an adult patient treated with losartan as a monotherapy for arterial hypertension.
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Moh'd Z
MZ
Al-Halawani
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Mohammad
M
Thawabi
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Fady
F
Asslo
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Hamid
H
Shaaban
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Fayez
F
Shamoon
Department of Internal Medicine, St. Michael's Medical Center, Seton Hall University School of Health and Medical Sciences, South Orange, NJ, USA.
Walid J
WJ
Baddoura
Drug-induced liver injury; hepatitis; losartan