Effect of gentamicin on the auditory analyzer in sexually immature animals.
Auditory function of immature rabbits was evaluated using two electrophysiological methods, brainstem auditory evoked response (BAER) and distortion product otoacoustic emission (DPOAE), in chronic experiments following administration of therapeutic doses of gentamicin. Impairment of auditory function manifested in increased thresholds and decreased amplitude of the 1st BAER peak was established. DPOAE parameters were not significantly changed. It was suggested that gentamicin decreased activity of spiral ganglion neurocytes in animals with immature auditory analyzer.
Department of Physiology, Medicobiological Faculty, N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
I N
IN
D'yakonova
Yu S
YS
Ishanova
I V
IV
Rakhmanova
A M
AM
Tikhomirov
D000161:Acoustic Stimulation; D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D007758:Ear, Inner / Q000187:drug effects / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005839:Gentamicins / Q000633:toxicity*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000503:physiopathology; D017084:Otoacoustic Emissions, Spontaneous; D011817:Rabbits
D000900:Anti-Bacterial Agents; D005839:Gentamicins