MicroRNA related polymorphisms and breast cancer risk.
Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk. First we evaluated 2,196 SNPs in a case-control study combining nine genome wide association studies (GWAS). Second, we further investigated 42 SNPs with suggestive evidence for association using 41,785 cases and 41,880 controls from 41 studies included in the Breast Cancer Association Consortium (BCAC). Combining the GWAS and BCAC data within a meta-analysis, we estimated main effects on breast cancer risk as well as risks for estrogen receptor (ER) and age defined subgroups. Five miRNA binding site SNPs associated significantly with breast cancer risk: rs1045494 (odds ratio (OR) 0.92; 95% confidence interval (CI): 0.88-0.96), rs1052532 (OR 0.97; 95% CI: 0.95-0.99), rs10719 (OR 0.97; 95% CI: 0.94-0.99), rs4687554 (OR 0.97; 95% CI: 0.95-0.99, and rs3134615 (OR 1.03; 95% CI: 1.01-1.05) located in the 3' UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively. DROSHA belongs to miRNA machinery genes and has a central role in initial miRNA processing. The remaining genes are involved in different molecular functions, including apoptosis and gene expression regulation. Further studies are warranted to elucidate whether the miRNA binding site SNPs are the causative variants for the observed risk effects.
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Sofia
S
Khan
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Finnish Institute of Occupational Health, Helsinki, Finland.
Dario
D
Greco
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Kyriaki
K
Michailidou
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Roger L
RL
Milne
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Taru A
TA
Muranen
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Tuomas
T
Heikkinen
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Kirsimari
K
Aaltonen
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Joe
J
Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Manjeet K
MK
Bolla
Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
Jianjun
J
Liu
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Per
P
Hall
Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
Astrid
A
Irwanto
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Keith
K
Humphreys
Human Genetics Division, Genome Institute of Singapore, Singapore, Singapore.
Jingmei
J
Li
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kamila
K
Czene
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jenny
J
Chang-Claude
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.
Rebecca
R
Hein
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Anja
A
Rudolph
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Petra
P
Seibold
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Dieter
D
Flesch-Janys
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
Olivia
O
Fletcher
Department of Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Julian
J
Peto
Department of Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Isabel
I
dos Santos Silva
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
Nichola
N
Johnson
Department of Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Lorna
L
Gibson
Department of Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Zoe
Z
Aitken
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
John L
JL
Hopper
Department of Pathology, The University of Melbourne, Melbourne, Australia.
Helen
H
Tsimiklis
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Minh
M
Bui
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Enes
E
Makalic
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Daniel F
DF
Schmidt
Department of Pathology, The University of Melbourne, Melbourne, Australia.
Melissa C
MC
Southey
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Carmel
C
Apicella
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Jennifer
J
Stone
Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.
Quinten
Q
Waisfisz
Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.
Hanne
H
Meijers-Heijboer
Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands.
Muriel A
MA
Adank
Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
Rob B
RB
van der Luijt
Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Alfons
A
Meindl
Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany; Center of Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany; Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.
Rita K
RK
Schmutzler
Max Planck Institute of Psychiatry, Munich, Germany.
Bertram
B
Müller-Myhsok
Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Peter
P
Lichtner
Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom.
Clare
C
Turnbull
Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Kingdom.
Nazneen
N
Rahman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.
Stephen J
SJ
Chanock
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America.
David J
DJ
Hunter
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
Angela
A
Cox
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom.
Simon S
SS
Cross
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Sheffield, United Kingdom.
Malcolm W R
MW
Reed
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Marjanka K
MK
Schmidt
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Annegien
A
Broeks
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Laura J
LJ
Van't Veer
Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Frans B
FB
Hogervorst
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Cancer Erlangen-EMN, Erlangen, Germany; David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California Los Angeles, California, United States of America.
Peter A
PA
Fasching
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Cancer Erlangen-EMN, Erlangen, Germany.
Michael G
MG
Schrauder
Institute of Human Genetics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
Arif B
AB
Ekici
University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Cancer Erlangen-EMN, Erlangen, Germany.
Matthias W
MW
Beckmann
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Stig E
SE
Bojesen
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Børge G
BG
Nordestgaard
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Sune F
SF
Nielsen
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Henrik
H
Flyger
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain; Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Javier
J
Benitez
Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain.
Pilar M
PM
Zamora
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
Jose I A
JI
Perez
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Christopher A
CA
Haiman
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Brian E
BE
Henderson
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America.
Fredrick
F
Schumacher
Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, Hawaii, United States of America.
Loic
L
Le Marchand
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Paul D P
PD
Pharoah
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Alison M
AM
Dunning
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Mitul
M
Shah
Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Robert
R
Luben
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Judith
J
Brown
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Fergus J
FJ
Couch
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America.
Xianshu
X
Wang
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Celine
C
Vachon
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Janet E
JE
Olson
Vesalius Research Center (VRC), VIB, Leuven, Belgium; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Diether
D
Lambrechts
Vesalius Research Center (VRC), VIB, Leuven, Belgium; Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Matthieu
M
Moisse
Oncology Department, University Hospital Gasthuisberg, Leuven, Belgium.
Robert
R
Paridaens
Oncology Department, University Hospital Gasthuisberg, Leuven, Belgium.
Marie-Rose
MR
Christiaens
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
Pascal
P
Guénel
Inserm (National Institute of Health and Medical Research), CESP (Center for Research in Epidemiology and Population Health), U1018, Environmental Epidemiology of Cancer, Villejuif, France; University Paris-Sud, UMRS 1018, Villejuif, France.
Thérèse
T
Truong
Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France.
Pierre
P
Laurent-Puig
Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France.
Claire
C
Mulot
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Frederick
F
Marme
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara
B
Burwinkel
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Andreas
A
Schneeweiss
Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Christof
C
Sohn
Research Oncology, Division of Cancer Studies, King's College London, Guy's Hospital, London, United Kingdom.
Elinor J
EJ
Sawyer
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Ian
I
Tomlinson
Clinical Science Institute, University Hospital Galway, Galway, Ireland.
Michael J
MJ
Kerin
Clinical Science Institute, University Hospital Galway, Galway, Ireland.
Nicola
N
Miller
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Irene L
IL
Andrulis
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Julia A
JA
Knight
Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
Sandrine
S
Tchatchou
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Laboratory Medicine, and the Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Ontario, Canada.
Anna Marie
AM
Mulligan
Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Thilo
T
Dörk
Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Natalia V
NV
Bogdanova
N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
Natalia N
NN
Antonenkova
Department of Epidemiology, University of California Irvine, Irvine, California, United States of America.
Hoda
H
Anton-Culver
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hatef
H
Darabi
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Mikael
M
Eriksson
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom; Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
Montserrat
M
Garcia-Closas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.
Jonine
J
Figueroa
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta
J
Lissowska
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America.
Louise
L
Brinton
Department of Human Genetics & Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.
Peter
P
Devilee
Department of Surgical Oncology, Leiden University Medical Center, Leiden, Netherlands.
Robert A E M
RA
Tollenaar
Family Cancer Clinic, Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, Netherlands.
Caroline
C
Seynaeve
Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands.
Christi J
CJ
van Asperen
Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Clinical Molecular Biology (EpiGen), University of Oslo, Oslo, Norway; Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway.
Vessela N
VN
Kristensen
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America.
Susan
S
Slager
Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America.
Amanda E
AE
Toland
Roswell Park Cancer Institute, Buffalo, New York, United States of America.
Christine B
CB
Ambrosone
Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Aghia Paraskevi Attikis, Athens, Greece.
Drakoulis
D
Yannoukakos
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Annika
A
Lindblom
Department of Oncology - Pathology, Karolinska Institutet, Stockholm, Sweden.
Sara
S
Margolin
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Paolo
P
Radice
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Paolo
P
Peterlongo
Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
Monica
M
Barile
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy; Cogentech Cancer Genetic Test Laboratory, Milan, Italy.
Paolo
P
Mariani
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Maartje J
MJ
Hooning
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
John W M
JW
Martens
Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
J Margriet
JM
Collée
Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Agnes
A
Jager
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Anna
A
Jakubowska
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jan
J
Lubinski
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland; Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland.
Katarzyna
K
Jaworska-Bieniek
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Katarzyna
K
Durda
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Graham G
GG
Giles
Anatomical Pathology, The Alfred Hospital, Melbourne, Australia.
Catriona
C
McLean
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany; University of Tübingen, Tübingen, Germany.
Hiltrud
H
Brauch
Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), Bochum, Germany.
Thomas
T
Brüning
Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Johanniter Krankenhaus, Bonn, Germany.
Yon-Dschun
YD
Ko
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
Hermann
H
Brenner
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.
Aida Karina
AK
Dieffenbach
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Volker
V
Arndt
Saarland Cancer Registry, Saarbrücken, Germany.
Christa
C
Stegmaier
Division of Genetics and Epidemiology and Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, United Kingdom.
Anthony
A
Swerdlow
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
Alan
A
Ashworth
Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom.
Nick
N
Orr
Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, United Kingdom.
Michael
M
Jones
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.
Jacques
J
Simard
Department of Medicine, McGill University, Montreal, Canada; Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada.
Mark S
MS
Goldberg
Départements de Santé Environnementale et Santé au Travail et de Médecine Sociale et Préventive, Université de Montréal, Montreal, Quebec, Canada.
France
F
Labrèche
Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.
Martine
M
Dumont
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland.
Robert
R
Winqvist
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Chemistry and Biocenter Oulu, University of Oulu, NordLab Oulu/Oulu University Hospital, Oulu, Finland.
Katri
K
Pylkäs
Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
Arja
A
Jukkola-Vuorinen
Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
Mervi
M
Grip
School of Medicine, Institute of Clinical Medicine, Oncology, University of Eastern Finland, Kuopio, Finland; Cancer Center, Kuopio University Hospital, Kuopio, Finland.
Vesa
V
Kataja
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Veli-Matti
VM
Kosma
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Jaana M
JM
Hartikainen
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland; Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland; Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland.
Arto
A
Mannermaa
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute
U
Hamann
Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Georgia
G
Chenevix-Trench
Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Carl
C
Blomqvist
Department of Clinical Genetics, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Kristiina
K
Aittomäki
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Douglas F
DF
Easton
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Heli
H
Nevanlinna
D020413:3' Untranslated Regions; D001665:Binding Sites; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D019295:Computational Biology; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011960:Receptors, Estrogen / Q000378:metabolism
D020413:3' Untranslated Regions; D035683:MicroRNAs; D011960:Receptors, Estrogen