The emerging role of extracellular vesicles as biomarkers for urogenital cancers.
The knowledge gained from comprehensive profiling projects that aim to define the complex genomic alterations present within cancers will undoubtedly improve our ability to detect and treat those diseases, but the influence of these resources on our understanding of basic cancer biology is still to be demonstrated. Extracellular vesicles have gained considerable attention in past years, both as mediators of intercellular signalling and as potential sources for the discovery of novel cancer biomarkers. In general, research on extracellular vesicles investigates either the basic mechanism of vesicle formation and cargo incorporation, or the isolation of vesicles from available body fluids for biomarker discovery. A deeper understanding of the cargo molecules present in extracellular vesicles obtained from patients with urogenital cancers, through high-throughput proteomics or genomics approaches, will aid in the identification of novel diagnostic and prognostic biomarkers, and can potentially lead to the discovery of new therapeutic targets.
University of Sao Paulo, Brazil.
Muhammad
M
Nawaz
University of Turin, Italy.
Giovanni
G
Camussi
BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Sweden.
Hadi
H
Valadi
University Medical Center Freiburg, Germany.
Irina
I
Nazarenko
BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Sweden.
Karin
K
Ekström
BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, University of Gothenburg, Sweden.
Xiaoqin
X
Wang
Princess Margaret Cancer Center, 101 College Street, TMDT 9-807, Toronto, ON M5G 1L7, Canada.
Simona
S
Principe
Monash University, Australia.
Neelam
N
Shah
University of Gujrat, Pakistan.
Naeem M
NM
Ashraf
University of Sao Paulo, Brazil.
Farah
F
Fatima
University of Sao Paulo, Brazil.
Luciano
L
Neder
Princess Margaret Cancer Center, 101 College Street, TMDT 9-807, Toronto, ON M5G 1L7, Canada.
Thomas
T
Kislinger
D014408:Biomarkers, Tumor / Q000097:blood / Q000652:urine*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D055252:Cell-Derived Microparticles / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D055354:Exosomes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D023281:Genomics; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000652:urine; D008297:Male; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism; D040901:Proteomics; D022142:Secretory Vesicles / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012661:Semen / Q000737:chemistry; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000652:urine
D014408:Biomarkers, Tumor