Ribonucleotides in bacterial DNA.
In all living cells, DNA is the storage medium for genetic information. Being quite stable, DNA is well-suited for its role in storage and propagation of information, but RNA is also covalently included in DNA through various mechanisms. Recent studies also demonstrate useful aspects of including ribonucleotides in the genome during repair. Therefore, our understanding of the consequences of RNA inclusion into bacterial genomic DNA is just beginning, but with its high frequency of occurrence the consequences and potential benefits are likely to be numerous and diverse. In this review, we discuss the processes that cause ribonucleotide inclusion in genomic DNA, the pathways important for ribonucleotide removal and the consequences that arise should ribonucleotides remain nested in genomic DNA.
a Department of Molecular, Cellular, and Developmental Biology , University of Michigan , Ann Arbor , MI , USA.
Jeremy W
JW
Schroeder
Justin R
JR
Randall
Lindsay A
LA
Matthews
Lyle A
LA
Simmons
D001412:Bacillus subtilis / Q000378:metabolism; D004256:DNA Polymerase I / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000737:chemistry* / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism*; D012265:Ribonucleotides / Q000378:metabolism*
D004269:DNA, Bacterial; D012265:Ribonucleotides; D004256:DNA Polymerase I
DNA polymerase; DNA repair; genome stability; mismatch repair; ribonucleotides