Visfatin concentrations in patients with endometrial cancer.
OBJECTIVE
Visfatin is one of the most recent proteins shown to be highly expressed in adipose tissue. The purpose of this study was to determine visfatin levels in patients with endometrial cancer (EC).


METHODS
A total of 90 patients (46 EC patients and 44 healthy controls) were included in the study. Fasting venous blood samples were collected from all patients. Serum visfatin levels were measured by an enzyme-linked immunosorbent assay (ELISA). The correlation between serum visfatin levels and clinicopathologic variables were determined.


RESULTS
Serum visfatin levels were found to be higher in patients with EC (p < 0.001). Visfatin concentrations were positively correlated with age (p = 0.002, r = 0.323), body mass index (BMI) (p = 0.001, r = 0.354), fasting insulin (p = 0.002, r = 0.326), total cholesterol (TC) (p = 0.006, r = 0.285), triglyceride (TG) (p < 0.001, r = 0.364) levels and homeostasis model-resistance index (HOMA-IR) (p = 0.007, r = 0.281) of patients. By using classification and regression trees (C&RT) method, we found that visfatin predicted patients with EC 100% and controls 81.8%.


CONCLUSIONS
Visfatin was the most important risk factor for occurrence of EC other than, age, BMI, Diabetes Mellitus and other biochemical factors like HDL, LDL, TG, TC. Clearly, there are largely unknown aspects of visfatin pathophysiology in EC and require further study.
Department of Obstetrics and Gynecology, Adnan Menderes University School of Medicine , Aydin , Turkey .
Sümeyra
S
Nergiz Avcioglu
Sunduz Ozlem
SO
Altinkaya
Mert
M
Küçük
Hasan
H
Yüksel
Imran Kurt
IK
Ömürlü
Serdar
S
Yanik
D000328:Adult; D000367:Age Factors; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D016889:Endometrial Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D054409:Nicotinamide Phosphoribosyltransferase
Endometrial cancer; insulin resistance; obesity; visfatin.