Decision limits and the reporting of cardiac troponin: Meeting the needs of both the cardiologist and the ED physician.
Cardiac troponin is the preferred biomarker for defining the acute coronary syndrome and acute myocardial infarction. Currently, the only decision limit formally endorsed with regard to the cardiac troponins is the 99th percentile. This is a "rule-in" criterion, intended to ensure that only persons with the acute coronary syndrome are reviewed. The 99th percentile is an arbitrary cut point and there are many problems associated with its application, including defining a truly healthy population, the difficulty of standardisation of cardiac troponin assays, especially but not only cardiac troponin I, and the effects of age and sex on this parameter. The Emergency Department (ED) screens many more persons for possible acute coronary syndromes than actually have the condition and their needs are best met by a "rule-out" test that enables them to clear their busy departments of the many persons who do not actually have the condition. The needs of the ED are not optimally met using the 99th percentile. The index of individuality for the cardiac troponins is small and significant changes consistent with an acute coronary syndrome can occur without the 99th percentile being exceeded. It appears that the ED may be better served by use of delta troponin changes rather than the 99th percentile, but there are problems with this approach, particularly in persons who present late when troponin release has plateaued. In addition, there are many non-acute coronary syndrome causes for cardiac troponin release. The needs of the cardiologist and the ED physician are so different that it may be inappropriate for both groups to use the same diagnostic criteria for cardiac troponin, and it is of great importance that cardiac troponin measurement be used as only one part of the assessment of the person presenting with possible acute coronary syndrome.
ACT Pathology , Garran, ACT , Australia .
Peter E
PE
Hickman
Bertil
B
Lindahl
Louise
L
Cullen
Gus
G
Koerbin
Jill
J
Tate
Julia M
JM
Potter
D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D002309:Cardiology / Q000379:methods* / Q000592:standards; D004635:Emergency Medicine / Q000379:methods* / Q000592:standards; D006801:Humans; D007118:Immunoassay; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis*; D009206:Myocardium / Q000378:metabolism*; D011237:Predictive Value of Tests; D012016:Reference Values; D014336:Troponin / Q000097:blood*
D015415:Biomarkers; D014336:Troponin
99th Percentile; acute coronary syndrome; cardiac troponin; delta change; index of individuality; reference change value