[Low concentration of iodixanol used in CT angiography of lower extremity arteriosclerosis obliterans].
OBJECTIVE
To evaluate the clinical diagnostic value of low concentration of iodixanol used in CT angiography (CTA) of lower extremity arteriosclerosis obliterans (LEASO).


METHODS
42 patients which were suspect diagnosed with LEASO were divided to A group (270 mgI/ml iodixanol, tube voltage 100 kV) and B group (350 mgI/ml iohexol, tube voltage 120 kV), 21 patients in each group. Measure the body mass index (BMI) before the CTA of lower extremity. CTA results were analyzed with the digital subtraction angiography (DSA) as the "gold standard".


RESULTS
There were no statistical difference of age, gender, BMI and CT value of the bifurcation of profunda femoral artery and superficial femoral artery, upper segment of anterior tibial artery and posterior tibial artery between A and B group. The diagnostic sensitivity and specificity of A and B groups of CTA were 97.0%, 99.1% and 98.3%, 99.5% for occlusion. Regard artery more than moderate stenosis (include moderate stenosis) as the overall statistics, the diagnostic sensitivity and specificity of A and B groups of CTA were 99.2%, 99.3% and 99.1%, 99.3%, the accuracy were 92.9% and 93.0%, the positive predictive and negative predictive value were 96.9%, 99.3% and 96.6%, 99.3%, respectively. The kappa value of A and B groups of CTA and DSA consistency test were 0.930 and 0.927, respectively.


CONCLUSIONS
The CTA with low concentration of iodixanol combine with low tube voltage can achieve superior conventional scanning imaging features, and has great clinical value in the diagnosis of LEASO, also is an effective method for the inspection, evaluation and follow-up.
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China.
Lizheng
L
Yao
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China. Email: ycsydzy@163.com.
Zhenyu
Z
Dai
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China.
Fuwan
F
Ding
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China.
Jun
J
Zhu
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China.
Lihui
L
Yan
Department of Radiology, the Affiliated Yancheng Hospital of Southeast University Medical College, Yancheng 224001, China.
Fei
F
Chen
D015901:Angiography, Digital Subtraction; D001162:Arteriosclerosis Obliterans / Q000000981:diagnostic imaging*; D003287:Contrast Media; D006801:Humans; D035002:Lower Extremity / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014283:Triiodobenzoic Acids
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C044834:iodixanol