Structurally diverse α-substituted benzopyran synthesis through a practical metal-free C(sp3)-H functionalization.
A trityl ion-mediated practical C-H functionalization of a variety of benzopyrans with a wide range of nucleophiles (organoboranes and C-H molecules) at ambient temperature has been disclosed. The metal-free reaction has an excellent functional group tolerance and high chemoselectivity and displays a broad scope with respect to both benzopyran and nucleophile partners, efficiently affording a collection of benzopyrans bearing diverse skeletons and α-functionalities in one step.
Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University , Jinan 250012, PR China.
Wenfang
W
Chen
Zhiyu
Z
Xie
Hongbo
H
Zheng
Hongxiang
H
Lou
Lei
L
Liu