Gender-linked stem cell alterations in stroke and postpartum depression.
Stroke is a significant unmet clinical need. The current stroke treatment of tissue plasminogen activator is limited to the very acute 4.5 h after disease onset which benefits only less than 3% of ischemic stroke patients. Our overarching hypothesis advances the notion that gender, which has been established as a comorbidity factor of stroke, plays a key role in regenerative medicine, in particular stem cell therapy. We hypothesize that gender is a key factor in culture-induced stemness of adult stem cells. Our goal is to provide new evidence supporting gender effects on stroke and stem cells for the purpose of enhancing our understanding of the pathophysiology of the disease and developing novel stem cell-based therapeutics targeting gender-relevant stress hormones as manifested in a stroke-postpartum depression paradigm.
Department of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida College of Medicine, Tampa, FL, USA.
Mibel M
MM
Pabón
Xun-Ming
XM
Ji
Jamie Winderbaum
JW
Fernandez
Cesar V
CV
Borlongan
D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D019052:Depression, Postpartum / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy
D006728:Hormones
Cerebral ischemia; Gender; Psychiatric disorder; Stem cell biology; Stem cell therapy