Best disease presenting as a giant serous pigment epithelial detachment.
OBJECTIVE
To report a case of Best disease presenting as a giant serous pigment epithelial detachment and misdiagnosed as central serous chorioretinopathy.


METHODS
Clinical examination and multimodal imaging, including color fundus photography, fluorescein angiography, fundus autofluorescence, and spectral domain optical coherence tomography are presented, as well as the results of electrooculography.


RESULTS
A 54-year-old Asian man underwent photodynamic therapy for a large serous pigment epithelial detachment presumed to be due to central serous chorioretinopathy. When the lesion was recalcitrant to therapy, further investigation revealed severely decreased Arden ratios consistent with Best disease.


CONCLUSIONS
There is a wide spectrum in the clinical presentation of Best disease. Diagnostic uncertainty can be elucidated with fundus autofluorescence, spectral domain optical coherence tomography imaging, electrooculography, and genetic testing.
*Division of Retinal Disorders and Ophthalmic Genetics, Jules Stein Eye Institute, UCLA, Los Angeles, California; and †Department of Ophthalmology, Greater Los Angeles VA Healthcare Center, Los Angeles, California.
Christine F
CF
Lin
David
D
Sarraf
D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology*; D057826:Vitelliform Macular Dystrophy / Q000150:complications* / Q000175:diagnosis