Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome.
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.
Department of Medicinal Chemistry, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Nabajyoti
0000-0002-5471-3503
N
Deka
Lupin Limited, Mumbai, India.
Swapnil
S
Bajare
Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Jessy
J
Anthony
Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Amrutha
A
Nair
Department of DMPK, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Anagha
A
Damre
Department of Discovery Informatics, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Dharmeshkumar
0000-0003-1601-256X
D
Patel
Department of Discovery Informatics, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Chandrika
C
B-Rao
Department of Medicinal Chemistry, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
H
H
Sivaramakrishnan
Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India ; Institute of Biomedicine, Department of Physiology, Biocenter of Oulu, Faculty of Medicine, Oulu University, P.O. Box 5000, Aapistie 7, 90014 Oulu, Finland.
Shivaprakash Jagalur
0000-0001-8285-551X
SJ
Mutt
Department of Pharmacology, Piramal Life Sciences Limited, 1 Nirlon Complex, Goregaon East, Mumbai 400 063, India.
Chandan
C
Wilankar
Department of Biochemistry, Haffkine Institute for Training, Research and Testing, Parel, Mumbai 400 012, India.
Rosalind
R
Marita