Synthesis of Pyrrolidines and Pyrroles via Tandem Amination/Cyanation/Alkylation and Amination/Oxidation Sequences.
Starting from a primary amine-tethered alkyne1, a copper-catalyzed three-component tandem amination/cyanation/alkylation sequence gives α-CN pyrrolidine6in good yield and regioselectivity. Also, a silver mediated tandem amination/oxidation of a secondary amine-tethered alkyne7produces functionalized pyrrole8in good yield. All reactions were conducted in one pot without any protection/deprotection steps.
Junbin
J
Han
Zhichao
Z
Lu
Gerald B
GB
Hammond
Bo
B
Xu
amination; cyanation; pyrroles; pyrrolidines; tandem