Six-Digit CPK and Mildly Affected Renal Function in McArdle Disease.
A previously healthy, white 12-year-old girl presented with diffuse body aches and poor perfusion. She developed severe respiratory failure and marked rhabdomyolysis and was mechanically ventilated. Although her CPK peaked at 500,000 IU/L, her renal function was mildly affected and her creatinine did not exceed the 0.8 mg/dL. The rhabdomyolysis was gradually resolved following aggressive fluid hydration. The patient did not require dialysis and made a complete recovery. Genetic studies revealed the diagnosis of McArdle disease.
University of Iowa Children's Hospital, Iowa City, IA 52242, USA.
George
0000-0003-0026-9336
G
Spyropoulos
St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA.
Panagiotis
0000-0002-7368-0436
P
Kratimenos
The Unterberg Children's Hospital at Monmouth Medical Center, Drexel University College of Medicine, Long Branch, NJ 07740, USA.
Andrew D
AD
Mcinnes
The Unterberg Children's Hospital at Monmouth Medical Center, Drexel University College of Medicine, Long Branch, NJ 07740, USA.
Richard J
RJ
DeGroote
St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, PA 19134, USA.
Ioannis
0000-0002-8396-9022
I
Koutroulis