The roles of Egr-2 in autoimmune diseases.
Being a member of the early growth response (Egr) family of transcription factors, Egr-2 is expressed in a variety of cell types of the immune system. Recent findings imply that Egr-2 is important in the development and function of T helper (Th) 17 cell, regulatory T (Treg) cell, as well as dendritic cell (DC). Although these cells perform significantly in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and systemic sclerosis, the roles of Egr-2 in the pathogenesis of autoimmune diseases can not be neglected. In this article, we will discuss recent findings about the important roles of Egr-2 in immune cells and the possible pathological roles of Egr-2 in autoimmune diseases.
Suzhou Municipal Center for Disease Prevention and Control, 72 Sanxiang Road, Suzhou, 215004, Jiangsu, People's Republic of China.
Min
M
Zhang
Ying
Y
Wang
Jian-Shu
JS
Wang
Jiao
J
Liu
Meng-Meng
MM
Liu
Hai-Bing
HB
Yang
D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D051767:Early Growth Response Protein 2; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000473:pathology; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology; D012595:Scleroderma, Systemic / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology*; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology*; D014158:Transcription, Genetic
C497326:EGR2 protein, human; D051767:Early Growth Response Protein 2