[Ocular manifestations of immune reconstitution inflammatory syndrome].
OBJECTIVE
To investigate the ocular manifestations of immune reconstitution inflammatory syndrome.


METHODS
Retrospective study. 372 patients were diagnosed as acquired immune deficiency syndrome from April 1997 to December 2012. The examination included best-corrected visual acuity, slit-lamp biomicroscopy, mydriatic fundus examination and colored fundus photography. Systemic examination including CD4(+)T- lymphocyte count and HIV viral load test before and after HAART treatment.


RESULTS
Fifty three eyes (33 patients) were diagnosed as cytomegalovirus retinitis, among which 16 eyes (10 patients) were later presented with immune reconstitution inflammatory syndrome after highly active anti-retroviral therapy. There are 9 males and 1 female, aged from 24 to 57 years old, with a mean of (39.0 ± 10.6) years old. The duration of HAART was 2 weeks to 2 years, with a mean of 5.3 months. All of the 16 eyes had decreased visual acuity, and 2 eyes had floaters. The best corrected visual acuity (BCVA) was light perception in 2 eyes, hand move to 0.05 in 5 eyes, 0.1 to 0.5 in 6 eyes, 0.6 to 1.0 in 3 eyes. 8 eyes appeared active iridocyclitis and 5 eyes appeared inactive iridocyclitis, 5 eyes had lens opacity, 9 eyes had vitreitis, 1 eye had pale optic disc, 2 eyes had optic disc edema, 4 eyes were found retinal detachment.


CONCLUSIONS
The improvement of the understanding of the ocular manifestations of IRIS is essential for diagnosis and treatment.
Chinese Academy of Medical Sciences, Peking Union Medical College, Peking Union Medical College Hospital Department of Ophthalmology, Beijing 100730, China.
Nan
N
Ma
Email: yejunjie@hotmail.com.
Junjie
J
Ye
Donghui
D
Li
Yang
Y
Han
Taisheng
T
Li
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D018791:CD4 Lymphocyte Count; D017726:Cytomegalovirus Retinitis / Q000175:diagnosis; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D005654:Fundus Oculi; D006678:HIV; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D019562:Viral Load; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity; D014822:Vitreous Body; D055815:Young Adult