Genetics of pigmentation in dogs and cats.
Color variation in companion animals has long been of interest to the breeding and scientific communities. Simple traits, like black versus brown or yellow versus black, have helped to explain principles of transmission genetics and continue to serve as models for studying gene action and interaction. We present a molecular genetic review of pigmentary variation in dogs and cats using a nomenclature and logical framework established by early leaders in the field. For most loci in which molecular variants have been identified (nine in dogs and seven in cats), homologous mutations exist in laboratory mice and/or humans. Exceptions include the K locus in dogs and the Tabby locus in cats, which give rise to alternating stripes or marks of different color, and which illustrate the continued potential of coat color genetics to provide insight into areas that transcend pigment cell biology.
HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806 and Department of Genetics, Stanford University, Stanford, California 94305; email: gbarsh@hudsonalpha.org , ckaelin@hudsonalpha.org.
Christopher B
CB
Kaelin
Gregory S
GS
Barsh
D000818:Animals; D002415:Cats / Q000235:genetics / Q000502:physiology*; D004285:Dogs / Q000235:genetics / Q000502:physiology*; D006200:Hair Color / Q000235:genetics*; D010860:Pigments, Biological / Q000235:genetics / Q000378:metabolism*
D010860:Pigments, Biological
cell physiology; comparative genetics; gene interaction; melanocyte biology