Cholesterol metabolism and immunity.
A study in mice implicates a cholesterol derivative in damping down the inflammatory response mediated by interleukin-1β and explaining, at least in part, the immunosuppressive effect of type I interferon, which is used in the treatment of multiple sclerosis.
Anna
A
Simon
D000818:Animals; D006888:Hydroxycholesterols / Q000276:immunology* / Q000378:metabolism; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D007370:Interferon Type I / Q000276:immunology; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors*; D054078:Mevalonate Kinase Deficiency / Q000276:immunology / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics; D013250:Steroid Hydroxylases / Q000235:genetics / Q000276:immunology*
D006888:Hydroxycholesterols; D007370:Interferon Type I; D053583:Interleukin-1beta; C007997:25-hydroxycholesterol; D013250:Steroid Hydroxylases; C507384:cholesterol 25-hydroxylase; D017853:Phosphotransferases (Alcohol Group Acceptor); C021796:mevalonate kinase