[Cilia and neuronal migrations].
In a landmark paper published in 1977, G. Albrecht-Buehler described a primary cilium on the surface of migrating fibroblasts, and noticed that cilia are oriented parallel to the direction of migration of fibroblasts. While the presence of a primary cilium on neural progenitors and on post-mitotic neurons was noted long ago, it has been observed on migrating cortical interneurons only recently. As in fibroblasts, the cilium of interneurons controls the directionality of migration. It plays an important role in the reorientation of cortical interneurons towards the cortical plate. The morphogen Shh, which is expressed in the migratory pathway of interneurons, is one of the signals that control this reorientation.
Institut du Fer à moulin, Inserm UMRS 839, université Pierre et Marie Curie, 17, rue du Fer à Moulin, 75005 Paris, France.
Christine
C
Métin
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000196:embryology; D002923:Cilia / Q000502:physiology*; D059330:GABAergic Neurons / Q000502:physiology* / Q000648:ultrastructure; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D007395:Interneurons / Q000502:physiology* / Q000648:ultrastructure; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology; D000072079:Patched Receptors; D011956:Receptors, Cell Surface / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D000072086:Smoothened Receptor
D053823:Hedgehog Proteins; D009419:Nerve Tissue Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C491023:SMO protein, human; C491022:Smo protein, mouse; D000072086:Smoothened Receptor