Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats.
We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200-300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Ikue
I
Kitazawa
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Shino
S
Ito
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Yusuke
Y
Kagawa
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Miki
M
Suehiro-Narita
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Naoto
N
Hashizume
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Yuka
Y
Minamisawa
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Aisuke
A
Nii
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Akio
A
Kawakami
Central Research Laboratories, Seikagaku Corporation, 1253 Tateno 3-chome, Higashiyamato, Tokyo 207-0021, Japan.
Shinichi
S
Nakajima
intravenous administration; macromolecular substances; mononuclear phagocyte system