Bilateral serous retinal detachment as a presenting sign of nephrotic syndrome.
We herein present a case of bilateral serous retinal detachment (SRD) as a presenting sign of nephrotic syndrome (NS). A 48-year-old man complained of decreased vision related to bilateral SRD. Laboratory tests revealed NS (serum albumin, 17 g/L: proteinuria, 15.40 g over 24 hours). Following treatment for edema with a diuretic, the bilateral SRD resolved completely, with a full recovery of the patient's vision. A kidney biopsy disclosed glomerular and vascular amyloid deposits; the amyloid stained strongly with anti-λ antiserum. Therefore, a diagnosis of AL amyloidosis was made. The sudden appearance of SRD should raise suspicion of a diagnosis of NS. Prompt recognition of this symptom is important for early treatment and restoration of the visual function.
Department of Nephrology, Pitie Salpetriere Hospital, France.
Hassan
H
Izzedine
Christine
C
Fardeau
Marion
M
Gauthier
Audrey
A
Fel
Philippe
P
Attias
Nawal
N
Benabdellah
Mohamed-Ali
MA
Sassi
Bahram
B
Bodaghi
D000686:Amyloidosis / Q000453:epidemiology; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D011507:Proteinuria; D012163:Retinal Detachment / Q000209:etiology*