Role of microRNAs in osteoblasts differentiation and bone disorders.
Advanced studies of single stranded endogenous ~22 nt microRNAs (miRNAs) have demonstrated their diverse biological functions including control of cell differentiation, cell cycle and pathological conditions. Recent studies suggest the potential application of miRNAs in stem cell engineering. miRNAs play a vital role as post-transcriptional regulators of gene expression which controls osteoblasts-mediated bone formation and osteoclasts related bone remodeling. Transcriptional and post-transcriptional mechanisms regulate the differentiation of osteoblasts and osteogenesis. The differentiation of osteoblasts is a key step in the development of skeletal muscles and it is involved in triggering the signaling pathways. Signaling pathways like TGF&amp;#946;, BMP and Wnt are regulated by miRNAs which in turn, are shown to be associated with bone dynamics and bone disorders. This recap highlights the role of miRNAs in osteoblasts differentiation and emphasizes their potential therapeutic role in metabolic bone disorders.
Yasir
Y
Arfat
Wei-Zhong
WZ
Xiao
Munazza
M
Ahmad
Fan
F
Zhao
Di-Jie
DJ
Li
Yu-Long
YL
Sun
Lifang
L
Hu
Chen
C
Zhihao
Ge
G
Zhang
Salman
S
Iftikhar
Peng
P
Shang
Tuan-Ming
TM
Yang
Key Laboratory for Space Bioscience & Biotechnology, Institute of Special Environmental Biophysics, Faculty of Life Sciences, Northwestern Polytechnical University, 127 Youyi Xilu, Xi'an, 710072, P.R. China. qianair@nwpu.edu.cn.
Ai-Rong
AR
Qian
D000818:Animals; D001847:Bone Diseases / Q000235:genetics*; D002454:Cell Differentiation / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D010006:Osteoblasts / Q000166:cytology*
D035683:MicroRNAs