Regression of advanced group e retinoblastoma with intraarterial chemotherapy.
OBJECTIVE
To report a case of regression of advanced retinoblastoma with intraarterial chemotherapy.


METHODS
A 25-month-old boy presented with extensive endophytic group E retinoblastoma with extensive vitreous seeds and total retinal detachment.


RESULTS
The patient underwent four sessions of intraarterial chemotherapy after which there was complete regression of vitreous seeds and near-complete calcification of the tumor.


CONCLUSIONS
Intraarterial chemotherapy is a novel treatment that is effective in selected cases of retinoblastoma. This technique allows selective delivery of chemotherapy to the involved tumor tissue with minimal systemic absorption.
*Ocular Oncology Service, Wills Eye Institute, Philadelphia, Pennsylvania †Department, of Cerebrovascular Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Aparna
A
Ramasubramanian
Neelema
N
Sinha
Robert H
RH
Rosenwasser
Carol L
CL
Shields