Localized retinal manifestations of paraneoplastic autoimmune retinopathy.
OBJECTIVE
Systemic neoplastic processes can affect the retina through autoimmune retinopathy. This process may present in a variety of patterns. A novel pattern of paraneoplastic autoimmune retinopathy has been described.


METHODS
Two patients presented with paraneoplastic vision changes. Optical coherence tomography and multifocal electroretinography were performed, which showed a unique focal retinal change in both patients. Case 1 is a 20-year-old woman with history of cutaneous melanoma. Case 2 is 67-year-old woman with history of breast cancer.


RESULTS
Both patients showed a localized area of foveal thinning that corresponded with areas of depression on multifocal electroretinography. Each tested positive for antiretinal antibodies.


CONCLUSIONS
This is a novel manifestation of paraneoplastic autoimmune retinopathy. Previously described cases have all affected the retina diffusely. These cases highlight the need to consider distant neoplastic processes when evaluating patient with similar presentations to those depicted here.
Department of Ophthalmology, University of Wisconsin, Madison, Wisconsin.
James A
JA
Eadie
Michael S
MS
Ip
James N
JN
Ver Hoeve
D000368:Aged; D001327:Autoimmune Diseases / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000150:complications; D005260:Female; D006801:Humans; D008545:Melanoma / Q000150:complications; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis*; D012164:Retinal Diseases / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000150:complications; D055815:Young Adult