[Relationship between resting heart rate and brachial-ankle pulse wave velocity in healthy Chinese population].
OBJECTIVE
To investigate the relationship between resting heart rate (RHR) and brachial-ankle pulse wave velocity (baPWV) in healthy Chinese population.


METHODS
This was a retrospective cohort study, and a total of 5 852 participants were selected with stratified random sampling from the 101 510 workers of Tangshan Kailuan company who received the health examination during 2010-2011 including epidemiological investigation, biochemical indicators measurement and baPWV measurement. A total of 5 440 participants met the inclusion criteria (aged 40 years or older, without stroke, transient ischemic attack and myocardial infarction) and 5 153 participants (3 110 males, mean age (55.1 ± 11.8) years old) with integral data were finally recruited into the final analysis. The observation population was divided into four groups according to RHR collected during health examinations:quartile 1 (RHR ≤ 63 beats/min, n = 1 405); quartile 2 (63 beats/min < RHR ≤ 69 beats/min, n = 1 176); quartile 3 (69 beats/min < RHR ≤ 76 beats/min, n = 1 322); quartile 4 (RHR > 76 beats/min, n = 1 250). Multivariate logistic regression analysis was used to analyze the relationship between RHR and baPWV.


RESULTS
(1) The mean baPWV was (1 586 ± 400) cm/s, and the detection rates of baPWV ≥ 1 400 cm/s was 61.8% (3 185/5 153). (2) The baPWV of quartile 1, 2, 3 and 4 were (1 511 ± 338) cm/s, (1 533 ± 329) cm/s, (1 574 ± 368) cm/s and (1 734 ± 462) cm/s, respectively, and the detection rates of baPWV ≥ 1 400 cm/s were 54.7% (769/1 405) , 56.0% (658/1 176), 63.1% (834/1 322) and 74.3% (929/1 150) , respectively. (3) Multiple logistic regression analysis showed that the detection rates of baPWV were significantly higher in quartile 2, 3 and 4 compared to quartile 1, and the OR values were 1.37 (95% CI: 1.11-1.69), 1.96 (95% CI: 1.59-2.41) and 2.60 (95% CI: 2.07-3.25), respectively, after adjusting for age, gender and systolic blood pressure, body mass index, fasting blood glucose, triglyceride, total cholesterol, high density lipoprotein cholesterol, hs-CRP, antihypertensive agents, smoking and exercise status.


CONCLUSIONS
RHR is positively associated with baPWV in healthy Chinese population.
Graduate School of Hebei United University, Tangshan 063000, China.
Jie
J
Tao
Dongqing
D
Li
Yan
Y
Dong
Email: drwusl@163.com.
Shouling
S
Wu
D000328:Adult; D000368:Aged; D000842:Ankle; D055109:Ankle Brachial Index; D044466:Asian People; D001783:Blood Flow Velocity; D001794:Blood Pressure; D015992:Body Mass Index; D002318:Cardiovascular Diseases; D008076:Cholesterol, HDL; D015331:Cohort Studies; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011673:Pulsatile Flow; D063177:Pulse Wave Analysis; D012189:Retrospective Studies
D008076:Cholesterol, HDL