Effects of goshajinkigan, hachimijiogan, and rokumigan on mechanical allodynia induced by Paclitaxel in mice.
Peripheral neuropathy is a major dose-limiting side effect of the chemotherapeutic agent paclitaxel. This study examined whether the three related traditional herbal formulations, goshajinkigan (GJG; Niú Chē Shèn Qì Wán), hachimijiogan (HJG; Bā Wèi Dì Huáng Wán), and rokumigan (RMG; Liù Wèi Wán), would relieve paclitaxel-induced mechanical allodynia in mice. A single intraperitoneal injection of paclitaxel (5 mg/kg) induced mechanical allodynia, which peaked on day 14 after injection. On day 14 after paclitaxel injection, oral administration of GJG (0.1-1.0 g/kg) produced a significant inhibition of established allodynia, but HJG and RMG did not affect the allodynia. Repeated oral administration of GJG (0.1-1.0 g/kg) starting from the day after paclitaxel injection did not affect allodynia development, but significantly inhibited allodynia exacerbation. Repeated oral administration of HJG produced a slight inhibition of allodynia exacerbation, but that of RMG did not. These results suggest that prophylactic administration of GJG is effective in preventing the exacerbation of paclitaxel-induced allodynia. The herbal medicines Plantaginis Semen ( Chē Qián Zǐ) and Achyranthis Radix ( Niú Xī), which are present in GJG but not in HJG, may contribute to the inhibitory action of GJG on the exacerbation of paclitaxel-induced allodynia.
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Tsugunobu
T
Andoh
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Ryo
R
Kitamura
Museum of Materia Medica, Research Center for Ethnomedicine, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.
Hirotoshi
H
Fushimi
Division of Pharmacognosy, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.
Katsuko
K
Komatsu
Division of Kampo Diagnostics, Institutes of Natural Medicine, University of Toyama, Toyama, Japan.
Naotoshi
N
Shibahara
Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Yasushi
Y
Kuraishi
Goshajinkigan; Hachimijiogan; Mechanical allodynia; Paclitaxel; Rokumigan