New tricycloalternarenes from fungus Alternaria sp.
Two new tricycloalternarenes I (1) and J (2), together with five known derivatives (3-7), were isolated from the culture of marine fungus Alternaria sp. The structures were elucidated by a combination of spectroscopic approach ((1)H, (13)C NMR, HMBC, COSY, and NOESY) and the low-temperature (100 K) single-crystal X-ray crystallography analysis. The antimicrobial assays of tricycloalternarenes I (1) and J (2) were tested.
a Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing 210093 , China.
Xiu
X
Shi
Wei
W
Wei
Wen-Jing
WJ
Zhang
Cheng-Pin
CP
Hua
Chao-Jun
CJ
Chen
Hui-Ming
HM
Ge
Ren-Xiang
RX
Tan
Rui-Hua
RH
Jiao
D000528:Alternaria / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002681:China; D018360:Crystallography, X-Ray; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D013297:Streptococcus pyogenes / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013729:Terpenes; C000598652:tricycloalternarene I; C000598653:tricycloalternarene J
Alternaria sp.; marine-derived fungi; phytotoxins; tricycloalternarenes derivatives