2D phase contrast blood flow velocity measurements of the thoracic vasculature: comparison of the effect of gadofosveset trisodium and gadopentetate dimeglumine.
The aim of this prospective study is to compare the performance of 2D time-resolved phase-contrast (PC) MRI prior to and after the administration of an intravascular (gadofosveset-trisodium) and extravascular (gadopentetate-dimeglumine) contrast agent in the same patient in the cardiovascular system. This study was approved by the ethics committee (Study-Number-07/Q0704/2) and registered with the MedicinesAndHealthcareProductsRegulatoryAgency (MHRA-Study-Number-28482/0002/001-0001, EudraCT-Number-2006-007042). All patients signed an informed consent. 20 patients were examined using a 1.5T MR-scanner and 32-channel-coil-technology. Gadopentetate-dimeglumine (GdD) and gadofosveset-trisodium (GdT) were administered in the same patient on consecutive days. Image quality, velocity-to-noise-ratios (VNRs) and standard-deviation of blood-flow-velocities (phase-noise) were compared between GdT, GdD and non-contrast-enhanced imaging. On both days pre- and post-contrast-scans were performed. The administration of GdT significantly improved the delineation of the perfused lumen and the VNR compared to GdD and non-contrast-enhanced imaging. Standard deviations of through-plane and in-plane velocity-measurements (phase-noise) were significantly reduced after GdT administration (p < 0.05). No significant differences (p > 0.05) were measured regarding absolute flow values prior to and after the administration of GdD and GdT. PC flow imaging benefits from the administration of an intravascular contrast agent by improving the delineation of the perfused lumen and reducing phase noise in flow measurements.
King's College London BHF Centre, Division of Imaging Science, Biomedical Research Centre of Guy's and St. Thomas' NHS Foundation Trust, London, UK, marcusmakowski@gmail.com.
Marcus R
MR
Makowski
Andrea J
AJ
Wiethoff
Hans U
HU
Ebersberger
René M
RM
Botnar
Reza
R
Razavi
Tobias
T
Schaeffter
Gerald F
GF
Greil
D000328:Adult; D001783:Blood Flow Velocity; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D055420:Perfusion Imaging / Q000379:methods*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012039:Regional Blood Flow; D059629:Signal-To-Noise Ratio; D013909:Thorax / Q000098:blood supply*; D055815:Young Adult
D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; D019786:Gadolinium DTPA; C109932:gadofosveset trisodium