Platinum(II) clovers targeting G-quadruplexes and their anticancer activities.
Two porphyrin-bridged tetranuclear platinum(II) complexes are found to effectively stabilize various kinds of G-quadruplexes. Their clover-like shape endows them with the capability of targeting G-quadruplexes rather than the double-stranded structure. Their excellent anticancer activity is the result of a dual effect, inhibition of the telomerase activity and repression of oncogene expression.
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. cesmzw@mail.sysu.edu.cn.
Xiao-Hui
XH
Zheng
Qian
Q
Cao
Yi-Liang
YL
Ding
Yi-Fang
YF
Zhong
Ge
G
Mu
Peter Z
PZ
Qin
Liang-Nian
LN
Ji
Zong-Wan
ZW
Mao
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D054856:G-Quadruplexes / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology; D019098:Telomerase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011166:Porphyrins; D019098:Telomerase