Significance of selected antioxidant enzymes in cancer cell progression.
Antioxidant enzymes (AOEs), including superoxide dismutase isoenzymes (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) along with glutathione reductase (GR), reduced glutathione (GSH) and glutathione transferase (GST), are thought to be necessary for life process in all oxygen-metabolizing cells by removing reactive oxygen species (ROS). The biological significance of AOEs in transformed cells is still unclear, but their capacity to survive may be affected by changes in cellular process such as proliferation, invasiveness, migration, apoptosis and drug resistance. This review summaries the significance of antioxidant enzymes in cancer cell progression mainly in an in vitro context.
Dr Rafał Jakub Bułdak, Medical University of Silesia, Katowice, School of Medicine with the Division of Dentistry, Department of Physiology in Zabrze, Jordana 19,, 41-808 Zabrze, Poland, tel./fax +48 32 272 23 62, e-mail: rbuldak@sum.edu.pl.
Rafał Jakub
RJ
Bułdak
Łukasz
Ł
Bułdak
Michał
M
Kukla
Andrzej
A
Gabriel
Krystyna
K
Zwirska-Korczala
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D018450:Disease Progression; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D017382:Reactive Oxygen Species; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase