Energetics of active fluctuations in living cells.
The nonequilibrium activity taking place in a living cell can be monitored with a tracer embedded in the medium. While microrheology experiments based on optical manipulation of such probes have become increasingly standard, we put forward a number of experiments with alternative protocols that, we claim, will provide insight into the energetics of active fluctuations. These are based on either performing thermodynamiclike cycles in control-parameter space or determining response to external perturbations of the confining trap beyond simple translation. We illustrate our proposals on an active itinerant Brownian oscillator modeling the dynamics of a probe embedded in a living medium.
Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
É
É
Fodor
Yukawa Institute for Theoretical Physics, Kyoto University, Kitashirakawa-oiwake cho, Sakyo-ku, Kyoto 606-8502, Japan.
K
K
Kanazawa
Yukawa Institute for Theoretical Physics, Kyoto University, Kitashirakawa-oiwake cho, Sakyo-ku, Kyoto 606-8502, Japan.
H
H
Hayakawa
Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
P
P
Visco
Laboratoire Matière et Systèmes Complexes, UMR 7057 CNRS/P7, Université Paris Diderot, 10 rue Alice Domon et Léonie Duquet, 75205 Paris cedex 13, France.
F
F
van Wijland
D002468:Cell Physiological Phenomena; D005583:Fourier Analysis; D008954:Models, Biological; D012212:Rheology; D013816:Thermodynamics