Viscoelastic Deterioration of the Carotid Artery Vascular Wall is a Possible Predictor of Coronary Artery Disease.
OBJECTIVE
The viscoelastic properties of the artery are known to be altered in patients with vascular diseases. However, few studies have evaluated the viscoelasticity of the vascular wall in humans. We sought to investigate the degree of viscoelastic deterioration of the carotid artery and assess its clinical implications.


METHODS
Between January 2011 and June 2013, patients in whom the toe-brachial index was measured at the vascular laboratory were included in this single-institute retrospective observational study. I(＊), a parameter of viscoelastic deterioration, was computed using a non-invasive ultrasonic Doppler effect sensor on the carotid artery. I(＊) is a non-dimensional value, and I(＊)>0 is considered abnormal. Other patient characteristics were identified and tested for correlations with I(＊).


RESULTS
The study included 383 patients. The mean I(＊) value was 0.13 ± 0.22 with a normal distribution. Factors that increased the I(＊) value were a female sex (0.18 ± 0.23 vs. 0.10 ± 0.21, P<0.001), age ≥ 60 (0.14 ± 0.22 vs. 0.06 ± 0.23, P<0.05) and systolic blood pressure of >140 (0.15 ± 0.22 vs. 0.10 ± 0.22, P<0.05). I(＊) abnormality was a significant risk factor for coronary artery disease (OR 2.20, 95% CI 1.00-4.80, P<0.05) in a univariate analysis. In the multivariate analysis, I(＊) abnormality was also found to be an independent risk factor for coronary artery disease (OR 4.56, 95% CI 1.21-30.1, P<0.05).


CONCLUSIONS
I(＊) may reflect the degree of atherosclerotic changes in the arterial wall and could possibly be used to predict coronary artery disease.
Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo.
Ryosuke
R
Taniguchi
Akihiro
A
Hosaka
Takuya
T
Miyahara
Katsuyuki
K
Hoshina
Hiroyuki
H
Okamoto
Kunihiro
K
Shigematsu
Tetsuro
T
Miyata
Ryuji
R
Sugiura
A Toshimitsu
AT
Yokobori
Toshiaki
T
Watanabe
D000368:Aged; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000503:physiopathology; D001809:Blood Viscosity; D002339:Carotid Arteries / Q000473:pathology*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D055119:Elastic Modulus; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013314:Stress, Mechanical; D014652:Vascular Diseases / Q000150:complications* / Q000503:physiopathology; D014783:Viscosity