Rhodium-catalyzed oxidative annulation of hydrazines with alkynes using a nitrobenzene oxidant.
Rhodium-catalyzed oxidative annulation of hydrazines with alkynes has been accomplished using 1,3-dinitrobenzene as an oxidant. A variety of hydrazines with alkynes were converted to 1-aminoindole derivatives in good to high yields. Mechanistic investigations support the idea that 1,3-dinitrobenzene serves as the oxidant during C-H activation. This is, to our knowledge, the first report of a nitrobenzene compound used as the oxidant in transition-metal-catalyzed C-H activation.
Shanghai Key Laboratory of Functional Materials Chemistry, Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China.
Deng Yuan
DY
Li
Shanghai Key Laboratory of Functional Materials Chemistry, Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China.
Hao Jie
HJ
Chen
Shanghai Key Laboratory of Functional Materials Chemistry, Key Lab for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China.
Pei Nian
PN
Liu