Use of combination therapy to successfully treat breakthrough Trichosporon asahii infection in an acute leukemia patient receiving voriconazole.
Trichosporon species is an important life-threatening opportunistic systemic pathogen, especially in leukemia patients. Voriconazole is proved to be a promising agent in past decade. However, recently we observed a case of breakthrough Trichosporon asahii infection while receiving voriconazole, which calls for an alternative treatment strategy. A combination therapy of liposomal amphotericin B (AmB) plus caspofungin - in which liposomal AmB dose was reduced due to renal toxicity - was administered to successfully treat this patient.
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Jia
J
Chen
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Feng
F
Chen
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Ying
Y
Wang
Respiratory Department, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Ling-Yi
LY
Yang
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Miao
M
Miao
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
Yue
Y
Han
Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China ; Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215006, China.
De-Pei
DP
Wu
Caspofungin; Liposomal amphotericin B; T. asahii; Voriconazole