Insulin-Like Growth Factor-I, Insulin-Like Growth factor Binding Protein-3 and Blood Hemoglobin Concentration in an Elderly Population.
BACKGROUND
Insulin-like growth factor-I (IGF-I) serum level decreases with age, and this decrease may underlie hemoglobin (Hb) decrease. The objective of the study was to assess the relationship between IGF-I and insulin-like growth factor binding protein-3 (IGFBP-3) serum levels and Hb, after adjustment especially for major nutritional factors in an elderly population because IGF-I system depends on nutritional state, often impaired in the elderly.


METHODS
Hemoglobin concentration was tested for 672 participants evaluated during an outpatient geriatric assessment. IGF-I and IGFBP-3 serum levels were assessed by Enzyme Linked Immunosorbent Assay. The molar ratio of IGF-I/IGFBP-3 that reflects the bioavailable IGF-I was calculated. Levels of IGF-I and IGFBP-3 were plotted against quartiles of Hb. Final linear models for IGF-I, IGFBP-3 and ratio molar included factors that could modify the Hb level.


RESULTS
Mean age (SD) of the sample was 78.0 (8.5) years old and 32% were men. After adjustment for age and sex, IGF-I serum level, IGFBP-3 serum level and molar ratio significantly increased with increasing quartiles of Hb. After adjustment for age, gender, diabetes, albumin, pre-albumin, renal function, total cholesterol, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers consumption, C-Reactive Protein, Hb was significantly associated and with IGF-I level (p = .002) and molar ratio (p = .02).


CONCLUSIONS
IGF-I serum level and IGF-I/IGFBP-3 molar ratio were associated with Hb in an elderly population, independently of nutritional biological parameters. Thus, the association between the IGF-I system and Hb merits further investigation to determine whether interventions that modulate circulating IGF-I or IGF-I/BP3 ratio might preserve Hb in the elderly.
AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Paris, France. INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France. emmanuelle.duron@brc.aphp.fr.
Emmanuelle
E
Duron
AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Jean-Sébastien
JS
Vidal
INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
Benoît
B
Funalot
INSERM, IFR65, 27 rue de Chaligny, Hôpital St-Antoine Paris, France.
Nadège
N
Brunel
INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
Cécile
C
Viollet
AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Anne-Sophie
AS
Rigaud
AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Florian
F
Labourée
INSERM, UMR-S894, Centre de psychiatrie et neurosciences, Paris, France.
Jacques
J
Epelbaum
INSERM, UMRS 938, Centre de Recherche St-Antoine, Paris, France.
Yves
Y
le Bouc
AP-HP, Hôpital Broca, Service de Gériatrie, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
Olivier
O
Hanon
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood; D060825:Cognitive Dysfunction / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D015577:Geriatric Assessment; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D009752:Nutritional Status
D006454:Hemoglobins; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I
Blood hemoglobin; Elderly subjects; Insulin-like Growth Factor-I; Insulin-like Growth factor Binding Protein-3.