Hippocampal physiology, structure and function and the neuroscience of schizophrenia: a unified account of declarative memory deficits, working memory deficits and schizophrenic symptoms.
Memory impairment is a consistent feature of the schizophrenic syndrome. Hippocampal dysfunction has also been consistently demonstrated. This review will discuss neurophysiological and neuroanatomical aspects of memory formation and how they relate to memory impairment in schizophrenia. An understanding of the cellular physiology and connectivity of the hippocampus with other regions can also aid in understanding the relationship between schizophrenic declarative or relational memory deficits, working memory deficits and the clinical symptoms of the syndrome.
Harvard Medical School, VA Boston Healthcare System, 940 Belmont Street Psychiatry 116A Brockton, MA 02301, USA.
Cynthia G
CG
Wible
hippocampus; memory; parietal; schizophrenia; social cognition; superior temporal sulcus