Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.
Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen (Denmark).
Theis S
TS
Wilbek
Tine
T
Skovgaard
Fiona J
FJ
Sorrell
Stefan
S
Knapp
Jens
J
Berthelsen
Kristian
K
Strømgaard
D000595:Amino Acid Sequence; D001549:Benzamides / Q000737:chemistry*; D020134:Catalytic Domain; D018360:Crystallography, X-Ray; D064550:Death-Associated Protein Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000235:genetics; D057075:Enzyme Assays; D005786:Gene Expression Regulation; D057166:High-Throughput Screening Assays; D006801:Humans; D007700:Kinetics; D008024:Ligands; D046210:Microfluidic Analytical Techniques; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry*; D011724:Pyridazines / Q000737:chemistry*; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry* / Q000235:genetics
D001549:Benzamides; D008024:Ligands; C121001:NR2B NMDA receptor; D047428:Protein Kinase Inhibitors; D011724:Pyridazines; D016194:Receptors, N-Methyl-D-Aspartate; C579096:DAPK1 protein, human; D064550:Death-Associated Protein Kinases
drug discovery; enzymes; inhibitors; phosphorylation; protein structures