Insights into RNA transcriptome profiling of cardiac tissue in obesity and hypertension conditions.
Several epidemiologic studies suggest that obesity and hypertension are associated with cardiac transcriptome modifications that could be further associated with inflammatory processes and cardiac hypertrophy. In this field, transcriptome studies have demonstrated their importance to elucidate physiologic mechanisms, pathways or genes involved in many biologic processes. Over the past decade, RNA microarray and RNA-seq analysis has become an essential component to examine metabolic pathways in terms of mRNA expression in cardiology. In this review, cardiac muscle gene expression in response to effects of obesity and hypertension will be focused, providing a broad view on cardiac transcriptome and physiologic and biochemical mechanisms involved in gene expression changes produced by these events, emphasizing the use of new technologies for gene expression analyses.
Universidade Católica de Brasília, Pós-Graduação em Ciências Genômicas e Biotecnologia Centro de Análises Proteômicas e Bioquímicas, Brasília, Brazil.
Alzenira de Fátima
Ade F
Costa
Octávio Luiz
OL
Franco
D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D032383:Myocytes, Cardiac / Q000378:metabolism; D009765:Obesity / Q000235:genetics*; D012313:RNA / Q000235:genetics* / Q000378:metabolism
D012313:RNA