Functional role of bdm during flagella biogenesis in Escherichia coli.
The biofilm-dependent modulation gene (bdm) has recently been shown to play a role in osmotic-induced formation of biofilm in Escherichia coli. In this study, we demonstrated that deletion of bdm results in down-regulation of flagella biosynthesis genes and, consequently, a defect in E. coli motility. In addition, we employed atomic force microscopy to confirm the absence of flagella-like structures on the surface of bdm-null cells. These findings indicate that bdm plays a key role in regulatory pathway for the formation of flagella.
Department of Life Science, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 156-756, Republic of Korea.
Ji-Sun
JS
Kim
Yu Jin
YJ
Kim
Sojin
S
Seo
Maeng-Je
MJ
Seong
Kangseok
K
Lee
D018441:Biofilms; D004926:Escherichia coli / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism*; D005407:Flagella / Q000235:genetics* / Q000378:metabolism*; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D012333:RNA, Messenger / Q000235:genetics
D029968:Escherichia coli Proteins; D012333:RNA, Messenger