Premature ejaculation - dose and duration dependent effect of fluoxetine: a histological study on seminal vesicle of albino rats.
BACKGROUND
Fluoxetine is a prototype drug of Selective Serotonin Reuptake Inhibitors. Its active demethylated metabolite has a half life of 7-10 d. Fluoxetine is used to treat depression and is also prescribed in premature ejaculation.


OBJECTIVE
In the present study dose and duration dependent effects of Fluoxetine on histology of seminal vesicle of the albino rats were observed.


METHODS
The present study was conducted on 36 adult male albino rats. Fluoxetine was administered intraperitoneally for 2 wk, 4 wk and 12 wk with mild (10mg/kg/day), moderate (20mg/kg/day) and severe doses (40mg/kg/day). Histological slides of Seminal vesicle were prepared and stained with Hematoxylin and Eosin stain.


RESULTS
On examination through the light microscope, the proliferation of primary, secondary and tertiary villi, increased crypt/alveoli, increased thickness of lamina propria, decreased epithelial cell height, metaplasia, changes in the amount of luminal eosinophilic secretory material in the form of scanty secretion in lumen of seminal vesicle.


CONCLUSIONS
Low doses for long duration and high doses for short duration of Fluoxetine produce histological changes in seminal vesicle of albino rats.
Assistant Professor, Department of Anatomy, Himalayan Institute of Medical Sciences , SRHU, Dehradun, U.K. India .
Alka
A
Aggarwal
Professor and Head, Department of Anatomy, Himalayan Institute of Medical Sciences , SRHU, Dehradun, U.K. India .
Sl
S
Jethani
Professor and Head, Department of Anatomy, Himalayan Institute of Medical Sciences , SRHU, Dehradun, U.K. India .
Rk
R
Rohatagi
Professor and Head, Department of Anatomy, Himalayan Institute of Medical Sciences , SRHU, Dehradun, U.K. India .
Juhi
J
Kalra
5-hydroxytryptamine; Delayed ejaculation; Male fertility; Metaplasia; Selective serotonin reuptake inhibitors