Repeated noninfectious endophthalmitis after intravitreal administration of bevacizumab: a report of two cases.
OBJECTIVE
To report on two patients with sterile endophthalmitis recurring twice after intravitreal bevacizumab injection.


METHODS
Two cases of sterile intraocular inflammation recurring after repeated intravitreal injections of bevacizumab are described, followed by a review of the literature.


RESULTS
Two patients presented with painful eyes and decreased vision associated with endophthalmitis several days after intravitreal bevacizumab injection. In both patients, vitreous specimens were sterile. The intraocular inflammation recurred after additional intravitreal injection of bevacizumab that was performed during subsequent follow-up.


CONCLUSIONS
This is the first report of sterile intraocular inflammation recurring after repeated intravitreal injections of bevacizumab. Awareness of the possible association between bevacizumab administration and sterile endophthalmitis may be warranted.
From the *Department of Ophthalmology, Tel Aviv Medical Center, Tel Aviv; †Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv; and ‡Department of Ophthalmology, Sheba Medical Center, Tel Hashomer, Israel.
Shiri
S
Soudry
Anat
A
Loewenstein
Joseph
J
Moisseiev