Incidence and mortality prognosis of dysnatremias in neurologic critically ill patients.
BACKGROUND
Dysnatremia, which is associated with increased mortality in general intensive care units (ICU), has not been thoroughly studied in neurologic ICU (NICU).


METHODS
Prevalence of dysnatremia was retrospectively assessed. The multivariable binary logistic regression model was used to determine the influence of dysnatremia on mortality.


RESULTS
Of 519 patients, 106 (20.4%) were admitted with hyponatremia and 177 (34.10%) with hypernatremia. Hypernatremia was detected in 69 (13.29%) patients on admission to NICU and in 108 patients (20.81%) during the ICU stay. However, the incidence of dysnatremia did not differ across the neurological categories (p = 0.4690). ICU stay in patients with acquired hypernatremia (22.3 ± 25.35 days) was longer than those with admission hypernatremia (13.5 ± 12.8 days) or with consistent normonatremia (16.16 ± 20.06 days). The other indicators such as Acute Physiology and Chronic Health Evaluation II, Glasgow Coma Scale score, urinary catheterization, and incidence of pneumonia were also associated with the serum sodium concentrations. Hypernatremia both on admission and acquired in NICU could significantly differentiate between survivors and nonsurvivors (p = 0.002 and <0.0001). However, only NICU-acquired hypernatremia was the independent risk factor for mortality with high sensitivity (p = 0.000).


CONCLUSIONS
Dysnatremia is more common in NICU, whereas only acquired-hypernatremia was independently associated with outcome.
Neurocritical Care Unit, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, PR China.
Yun-Zhou
YZ
Zhang
Jing-Yuan
JY
Qie
Qing-Hong
QH
Zhang
D000328:Adult; D000368:Aged; D016638:Critical Illness / Q000453:epidemiology; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D006955:Hypernatremia / Q000453:epidemiology*; D007010:Hyponatremia / Q000453:epidemiology*; D015994:Incidence; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications*; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors