The Relationship between Uterine Myoma Growth and the Endocrine Disruptor in Postmenopausal Women.
OBJECTIVE
To investigate the number of leiomyoma patients-exposed to bisphenol A (BPA) and to observe whether the serum concentration of BPA is related to leiomyoma growth.


METHODS
A total of 158 patients were recruited for this study. Leiomyoma patients were divided into three groups, mild (n = 48), moderate (n = 32) and severe (n = 28), according to the size of leiomyomas. The control (n = 30) group was defined as having no leiomyomas. Transvaginal ultrasonography was used to identify and measure the leiomyomas. Serum BPA concentrations were measured by enzyme-linked immunosorbent assay.


RESULTS
BPA was detected in 87.0% out of a total of 158 samples, and in 86.0% out of 108 leiomyoma patients. In detail, the detection rates of serum BPA were 88.0% in the control group, 77.2% in the mild group, 90.0% in the moderate group and 96.0% in the severe group. The mean BPA concentration in the control group was 0.558 ± 0.097 ng/mL, the leiomyoma groups, the mean BPA concentrations were 0.274 ± 0.063 ng/mL (mild), 0.346 ± 0.064 ng/mL (moderate) and 0.647 ± 0.039 ng/mL (severe) (P = 0.0003). Values represent the mean ± standard error.


CONCLUSIONS
The detection rates of serum BPA in the control and leiomyoma groups were 88.0% and 86.0%, respectively. However, there was no significant difference in the serum BPA concentrations between the control and leiomyoma groups. To verify the effect of BPA on leiomyoma growth, a close and sequential monitoring is recommended for people who are at risk for uterine leiomyoma.
Kosin University Graduate School, Busan, Korea.
Eun Ho
EH
Jeong
Department of Obstetrics and Gynecology, Wonkwang University College of Medicine, Iksan, Korea.
Gi Youn
GY
Hong
Department of Obstetrics and Gynecology, Wonkwang University College of Medicine, Iksan, Korea.
Byoung Ryun
BR
Kim
Department of Obstetrics and Gynecology, Wonkwang University College of Medicine, Iksan, Korea.
Seong Nam
SN
Park
Department of Obstetrics and Gynecology, Soonchunhyang University College of Medicine, Bucheon, Korea.
Hae-Hyeog
HH
Lee
Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Yangsan, Korea.
Yong-Jin
YJ
Na
Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Korea.
Jeong
J
Namkung
Endocrine disruptors; Leiomyoma; Uterus