Arthritis and benznidazole: more closely related than we thought.
Chagas disease is a parasitic infection that leads to a significant public health problem in countries where the disease is endemic and where it is nonendemic. Benznidazole is the most commonly used drug for the etiological treatment of Chagas disease. Patients treated with benznidazole suffer frequent adverse drug reactions. Although arthralgia is common, arthritis has been reported as a very rare side effect. The objective of this study was to describe arthritis in a cohort of Trypanosoma cruzi-infected patients treated with benznidazole.
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain edel.aldasoro@cresib.cat jgascon@clinic.ub.es.
E
E
Aldasoro
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
M J
MJ
Pinazo
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
I
I
Oliveira
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
J
J
Munoz
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
E
E
Posada
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
A
A
Requena-Méndez
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain.
N
N
Serret
ISGlobal, Barcelona Centre for International Health Research (CRESIB), Hospital Clinic, University of Barcelona, Barcelona, Spain edel.aldasoro@cresib.cat jgascon@clinic.ub.es.
J
J
Gascon
D000328:Adult; D001168:Arthritis / Q000139:chemically induced*; D014355:Chagas Disease / Q000188:drug therapy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014344:Trypanocidal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D055815:Young Adult
D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole