Cytotoxicity of doxycycline effluent generated by the Fenton process.
This study aims at determining the Minimum Inhibitory Concentration with Escherichia coli ATCC 25922 and cytotoxicity to L929 cells (ATCC CCL-1) of the waste generated by doxycycline degradation by the Fenton process. This process has shown promise in this treatment thanks mainly to the fact that the waste did not show any relevant inhibitory effect on the test organism and no cytotoxicity to L-929 cells, thus demonstrating that the antibiotic properties were inactivated.
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-900 São Paulo, SP, Brazil.
Alexandre Augusto
AA
Borghi
Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, University Town Zeferino Vaz, Rua Monteiro Lobato 255, 13083-862 Campinas, SP, Brazil.
Laura
0000-0002-2831-4795
L
Oliveira-Nascimento
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-900 São Paulo, SP, Brazil.
Marco Antônio
MA
Stephano
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-900 São Paulo, SP, Brazil.
Paula Monteiro
PM
de Souza
Department of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, Via Opera Pia 15, 16145 Genoa, Italy.
Attilio
0000-0003-2488-6080
A
Converti
Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, Bloco 16, Avenida Prof. Lineu Prestes 580, 05508-900 São Paulo, SP, Brazil.
Mauri Sérgio Alves
MS
Palma
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000633:toxicity; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004318:Doxycycline / Q000737:chemistry* / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000737:chemistry* / Q000633:toxicity
D000900:Anti-Bacterial Agents; C045076:Fenton's reagent; D014874:Water Pollutants, Chemical; D006861:Hydrogen Peroxide; D007501:Iron; D004318:Doxycycline