Design, synthesis, and biological activities of aromatic gossypol Schiff base derivatives.
A series of aromatic gossypol Schiff bases have been successfully synthesized via a feasible chemical modification. The antiviral activity against tobacco mosaic virus (TMV) of these gossypol Schiff bases has been tested for the first time. The bioassay studies indicated most of these derivatives exhibited excellent anti-TMV activity, in which o-trifluoromethylaniline Schiff base (19) displayed the best antiviral activities. Furthermore, compound 19 exhibited an eminent anti-TMV effect in the field and low toxicity to mice. These results suggest it is a promising candidate for the inhibitor of plant virus.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University , Tianjin 300071, People's Republic of China.
Ling
L
Li
Zheng
Z
Li
Kailiang
K
Wang
Sheng
S
Zhao
Jiming
J
Feng
Jiarui
J
Li
Peiwen
P
Yang
Yuxiu
Y
Liu
Lizhong
L
Wang
Yongqiang
Y
Li
Hui
H
Shang
Qingmin
Q
Wang
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006072:Gossypol / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D010935:Plant Diseases / Q000821:virology; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014026:Nicotiana / Q000821:virology; D014027:Tobacco Mosaic Virus / Q000187:drug effects
D000998:Antiviral Agents; D012545:Schiff Bases; D006072:Gossypol
Schiff base; anti-TMV activity; gossypol; structure−activity relationships; synthesis