Scale-free brain dynamics under physical and psychological distress: pre-treatment effects in women diagnosed with breast cancer.
Stressful life events are related to negative outcomes, including physical and psychological manifestations of distress, and behavioral deficits. Patients diagnosed with breast cancer report impaired attention and working memory prior to adjuvant therapy, which may be induced by distress. In this article, we examine whether brain dynamics show systematic changes due to the distress associated with cancer diagnosis. We hypothesized that impaired working memory is associated with suppression of "long-memory" neuronal dynamics; we tested this by measuring scale-free ("fractal") brain dynamics, quantified by the Hurst exponent (H). Fractal scaling refers to signals that do not occur at a specific time-scale, possessing a spectral power curve P(f)∝ f(-β); they are "long-memory" processes, with significant autocorrelations. In a BOLD functional magnetic resonance imaging study, we scanned three groups during a working memory task: women scheduled to receive chemotherapy or radiotherapy and aged-matched controls. Surprisingly, patients' BOLD signal exhibited greater H with increasing intensity of anticipated treatment. However, an analysis of H and functional connectivity against self-reported measures of psychological distress (Worry, Anxiety, Depression) and physical distress (Fatigue, Sleep problems) revealed significant interactions. The modulation of (Worry, Anxiety) versus (Fatigue, Sleep Problems, Depression) showed the strongest effect, where higher worry and lower fatigue was related to reduced H in regions involved in visuospatial search, attention, and memory processing. This is also linked to decreased functional connectivity in these brain regions. Our results indicate that the distress associated with cancer diagnosis alters BOLD scaling, and H is a sensitive measure of the interaction between psychological versus physical distress.
Rotman Research Institute, Baycrest Hospital, Toronto, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Canada.
Nathan W
NW
Churchill
Bernadine
B
Cimprich
Mary K
MK
Askren
Patricia A
PA
Reuter-Lorenz
Mi Sook
MS
Jung
Scott
S
Peltier
Marc G
MG
Berman
D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001943:Breast Neoplasms / Q000523:psychology*; D063132:Connectome; D005260:Female; D017709:Fractals; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008570:Memory, Short-Term / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology
brain dynamics; breast cancer; distress; fractal scaling; functional connectivity; functional magnetic resonance imaging; scale-free