Solid-state NMR as an effective method of polymorphic analysis: solid dosage forms of clopidogrel hydrogensulfate.
Clopidogrel hydrogensulfate (HSCL) is an antiplatelet agent, one of top-selling drugs in the world. In this paper, we have described a rapid and convenient method of verification which polymorph of HSCL is present in its final solid dosage form. Our methodology based on solid-state NMR spectroscopy and ab initio gauge-including projector-augmented wave calculations of NMR shielding constants is appropriate for currently available commercial solid dosage forms of HSCL. Furthermore, such structural characterization can assist with the development of new pharmaceutical products containing HSCL and also be useful in the identification of counterfeit drugs.
Faculty of Pharmacy, Medical University of Warsaw, Department of Inorganic and Analytical Chemistry, Warsaw, 02-093, Poland.
Edyta
E
Pindelska
Lukasz
L
Szeleszczuk
Dariusz Maciej
DM
Pisklak
Andrzej
A
Mazurek
Waclaw
W
Kolodziejski
D002626:Chemistry, Pharmaceutical; D000077144:Clopidogrel; D058110:Counterfeit Drugs / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry*; D011044:Poland; D058921:Purinergic P2Y Receptor Antagonists / Q000737:chemistry*; D011786:Quality Control; D011789:Quantum Theory; D013431:Sulfates / Q000737:chemistry; D013607:Tablets; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000737:chemistry; D058067:Wavelet Analysis
D058110:Counterfeit Drugs; D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D013431:Sulfates; D013607:Tablets; D000077144:Clopidogrel; D013988:Ticlopidine
GIPAW calculations; ab initio calculations; clopidogrel hydrogensulfate; crystal structure; polymorphism; solid dosage forms; solid-state NMR