Circadian rhythm of plasma and urinary angiotensinogen in healthy volunteers and in patients with chronic kidney disease.
The urinary angiotensinogen (AGT) excretion rate could be a novel biomarker for the intrarenal activity of the renin-angiotensin system. Little is known about the circadian rhythm of AGT levels in plasma or urine. In this short article, making use of data in plasma and urine of healthy volunteers and patients with chronic kidney diseases, we first report that we were unable to find evidence for a circadian rhythm of AGT under any condition. Next we critically discuss to what degree elevated urinary AGT levels might be considered an independent biomarker that is not simply the non-specific consequence of proteinuria.
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Faculty of Medicine, Japan.
Yoko
Y
Nishijima
Department of Pharmacology, Kagawa University Faculty of Medicine, Japan hkobori@med.kagawa-u.ac.jp.
Hiroyuki
H
Kobori
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Faculty of Medicine, Japan.
Kumiko
K
Kaifu
Department of Pharmacology, Kagawa University Faculty of Medicine, Japan.
Tomoko
T
Mizushige
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Faculty of Medicine, Japan.
Taiga
T
Hara
Department of Pharmacology, Kagawa University Faculty of Medicine, Japan.
Akira
A
Nishiyama
Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University Faculty of Medicine, Japan.
Masakazu
M
Kohno
D000328:Adult; D000803:Angiotensin I / Q000378:metabolism; D000808:Angiotensinogen / Q000097:blood* / Q000652:urine*; D015415:Biomarkers / Q000378:metabolism; D002940:Circadian Rhythm; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D011507:Proteinuria / Q000150:complications; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000652:urine*
D015415:Biomarkers; D000808:Angiotensinogen; D000803:Angiotensin I
Angiotensinogen; CKD; circadian rhythm; healthy volunteers; plasma; urine