Epistasis analysis using multifactor dimensionality reduction.
Here we introduce the multifactor dimensionality reduction (MDR) methodology and software package for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the key functions of the open-source MDR software package that is freely distributed. We end with a few examples of published studies of complex human diseases that have used MDR.
Department of Genetics, Geisel School of Medicine, DHMC, One Medical Center Dr., HB 7937, Lebanon, NH, 03756, USA, Jason.H.Moore@Dartmouth.edu.
Jason H
JH
Moore
Peter C
PC
Andrews
D016022:Case-Control Studies; D004843:Epistasis, Genetic; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D058011:Multifactor Dimensionality Reduction / Q000379:methods*; D019655:Quantitative Trait, Heritable; D013223:Statistics as Topic; D013269:Stochastic Processes; D001749:Urinary Bladder Neoplasms / Q000235:genetics