Body fat distribution and associations with metabolic and clinical characteristics in bipolar individuals.
Overweight and obesity differentially affect bipolar disorder (BD) and are associated with a poorer prognosis. Herein, we sought to evaluate body fat distribution in a well-characterized BD sample. Anthropometric measures (i.e., body mass index, waist-to-hip ratio, waist-to-height ratio, waist circumference, hip circumference, and lipometry) of 100 BD individuals were compared with data of 57 matched mentally healthy controls. Additionally, fasting serum parameters including metabolic parameters and monoamines were analyzed. Findings indicate that similar to US BD cohorts, Austrian patients exhibit an increased central body fat accumulation (i.e., higher subcutaneous adipose tissue at upper abdomen) accompanying with the harmful IDF-defined metabolic syndrome. In addition, positive associations between epinephrine as well as staging and fat parameters were detected.
Department of Psychiatry, University Clinic for Psychiatry, Medical University Graz, Auenbruggerplatz 31, 8036, Graz, Austria.
Nina
N
Lackner
Harald
H
Mangge
Eva Z
EZ
Reininghaus
Roger S
RS
McIntyre
Susanne A
SA
Bengesser
Armin
A
Birner
Bernd
B
Reininghaus
Hans-Peter
HP
Kapfhammer
Sandra J
SJ
Wallner-Liebmann
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000886:Anthropometry; D015306:Biogenic Monoamines / Q000097:blood; D001714:Bipolar Disorder / Q000097:blood / Q000150:complications*; D050218:Body Fat Distribution; D015992:Body Mass Index; D015331:Cohort Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology*; D008875:Middle Aged; D015999:Multivariate Analysis; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D011795:Surveys and Questionnaires; D055105:Waist Circumference; D049629:Waist-Hip Ratio; D055815:Young Adult
D015306:Biogenic Monoamines