A new schistosomicidal and antioxidative phenylpropanoid from Astragalus englerianus.
A new phenylpropanoid, (E)-2,3,4-trimethoxy-5-(1-propenyl)phenol (1), along with five known aromatic compounds (2-6), was isolated from the methanol extract of roots of Astragalus englerianus. Their structures were elucidated based on the analyses of extensive spectroscopic data and comparison of their physicochemical properties. Compounds 1 and 2 were evaluated schistosomicidal activities, and all the isolated compounds were tested for their antioxidant activities in vitro. Compound 1 showed significant schistosomicidal activity with worm mortality rates of 66.7% and 83.3% within 12 and 24 h in a drug-containing (1.16 mM) RPMI 1640 medium, respectively. Also, compound 1 exhibited excellent antioxidant activity (2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl free radical-scavenging capability) with an IC50 value of 81.3 ± 1.3 μM.
a College of Pharmacy and Chemistry, Institute of Materia Medica, Dali University , Dali 671000 , China.
Chao-Jiang
CJ
Xiao
Yu
Y
Zhang
Lin
L
Qiu
Wei
W
Xu
Ming-Zao
MZ
Zhao
Xiang
X
Dong
Bei
B
Jiang
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry; D015394:Molecular Structure; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010851:Picrates / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D012547:Schistosoma / Q000187:drug effects; D012556:Schistosomicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C000602413:(E)-2,3,4-trimethoxy-5-(1-propenyl)phenol; D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D010666:Phenylpropionates; D010851:Picrates; D012556:Schistosomicides; C004931:1,1-diphenyl-2-picrylhydrazyl
Astragalus englerianus; antioxidant activity; phenylpropanoid; schistosomicidal