Novel RNA modifications in the nervous system: form and function.
Modified RNA molecules have recently been shown to regulate nervous system functions. This mini-review and associated mini-symposium provide an overview of the types and known functions of novel modified RNAs in the nervous system, including covalently modified RNAs, edited RNAs, and circular RNAs. We discuss basic molecular mechanisms involving RNA modifications as well as the impact of modified RNAs and their regulation on neuronal processes and disorders, including neural fate specification, intellectual disability, neurodegeneration, dopamine neuron function, and substance use disorders.
National Institute on Drug Abuse, Bethesda, Maryland 20892, satterleej@nida.nih.gov.
John S
JS
Satterlee
RNA Institute, State University at Albany, Albany, New York 12222.
Maria
http://orcid.org/0000-0002-1452-8493
M
Basanta-Sanchez
Wellcome Trust, Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom.
Sandra
http://orcid.org/0000-0001-7352-9392
S
Blanco
Stanford University, Department of Genetics, Stanford, California 94305.
Jin Billy
JB
Li
Department of Pharmacology, Weill Medical College, Cornell University, New York, New York 10065.
Kate
K
Meyer
National Institute on Drug Abuse, Bethesda, Maryland 20892.
Jonathan
J
Pollock
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, Massachusetts 02129-4404, and.
Ghazaleh
G
Sadri-Vakili
Max-Delbrück-Centrum für Molekulare Medizin, 13092 Berlin, Germany.
Agnieszka
A
Rybak-Wolf
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008745:Methylation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism*; D017393:RNA Editing; D000079962:RNA, Circular; D022661:RNA, Untranslated / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D019966:Substance-Related Disorders / Q000235:genetics / Q000378:metabolism
D000079962:RNA, Circular; D022661:RNA, Untranslated; D017470:Receptors, Glutamate; D012313:RNA