Significance of IMP3, nucleophosmin, and Ki-67 expression in papillary thyroid carcinoma.
The purpose of our study was to investigate the diagnostic value of expression of IMP3, nucleophosmin, and correlation of these markers with Ki-67 proliferation index in papillary thyroid carcinoma and benign neoplasms of thyroid gland. The aim was also to investigate whether there is a difference between papillary and micropapillary carcinomas with regard to clinicopathologic parameters beside IMP3, nucleophosmin, and Ki-67 proliferation index. It was concluded that IMP3 and nucleophosmin cannot be a routine diagnostic marker for discrimination of papillary carcinomas and benign lesions. IMP3 positive staining was quite scarce in IMP3 positive papillary carcinomas although specifity of IMP3 is 100%. A statistically significant correlation was not detected between nucleophosmin, IMP-3, and Ki-67 proliferation index. A statistically significant correlation was found between tumor size, lymphovascular embolism, and Ki-67 proliferation index. There was also significant correlation between tumor size and lymphovascular embolism.
Pamukkale University, Kinikli, Denizli, Turkey.
Aygun
A
Yorukoglu
Pamukkale University, Kinikli, Denizli, Turkey nagihancol@yahoo.com.
Nagihan
N
Yalcin
Izmir Katip Çelebi University, Izmir, Turkey.
Arzu
A
Avci
Izmir Katip Çelebi University, Izmir, Turkey.
Fulya
F
Cakalagaoglu
Pamukkale University, Kinikli, Denizli, Turkey.
Guzin
G
Yaylali
Pamukkale University, Kinikli, Denizli, Turkey.
Fulya
F
Akin
Izmir Katip Çelebi University, Izmir, Turkey.
Mehmet
M
Haciyanli
Pamukkale University, Kinikli, Denizli, Turkey.
Akin
A
Ozden
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D005260:Female; D006044:Goiter, Nodular / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism*; D000090243:Nucleophosmin; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012680:Sensitivity and Specificity; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D013966:Thyroiditis / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
D014408:Biomarkers, Tumor; C498780:IGF2BP3 protein, human; D019394:Ki-67 Antigen; C000716967:NPM1 protein, human; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D000090243:Nucleophosmin
IMP3; immunohistochemistry; nucleophosmin; papillary carcinoma; thyroid