Ionic α-helical polypeptides toward nonviral gene delivery.
The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water-soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water-soluble α-helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA (siRNA) delivery.
Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Rujing
R
Zhang
Ziyuan
Z
Song
Lichen
L
Yin
Nan
N
Zheng
Haoyu
H
Tang
Hua
H
Lu
Nathan P
NP
Gabrielson
Yao
Y
Lin
Kyung
K
Kim
Jianjun
J
Cheng
D001672:Biocompatible Materials / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D006801:Humans; D007477:Ions; D010455:Peptides / Q000737:chemistry*; D010539:Permeability; D011108:Polymers / Q000737:chemistry; D017433:Protein Structure, Secondary; D034741:RNA, Small Interfering / Q000378:metabolism; D053838:Scattering, Small Angle; D023822:Tissue Engineering / Q000379:methods; D014965:X-Rays
D001672:Biocompatible Materials; D007477:Ions; D010455:Peptides; D011108:Polymers; D034741:RNA, Small Interfering