External application of the volatile oil from Blumea balsamifera may be safe for liver--a study on its chemical composition and hepatotoxicity.
Ainaxiang (Blumea balsamifera), also known as Sambong, is an important ancient medicinal herb in Southeast Asia. It is rich in volatile oil, and still widely used nowadays for skin wound healing and treatment of sore throats. We analyzed the volatile oil from Blumea balsamifera (BB oil) by gas chromatography-mass spectrometry (GC-MS). Forty one components, including l-borneol, were identified. Next, the damaging effects of BB oil diluted with olive oil on liver at different concentrations (100%, 50%, 20%), were evaluated, using both normal and wounded skin. Plasma ALT, AST, ALP and TBili were assessed, along with liver histopathology. The results showed that serum levels of liver toxicity markers in the high concentration groups (100% w/v) increased compared with control groups, whereas no significant changes was observed in histopathology of liver samples. In the wound groups, treatment with BB oil resulted in a decrease in serum toxicity index, compared with normal animal groups. This study confirms the safety of short term BB oil consumption, though high BB oil doses may lead to mild liver injury and this response might be weakened in the case of cutaneous wounds. These results are expected to be helpful for guiding appropriate therapeutic use of BB oil.
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. blumeachina@126.com.
Yu-Xin
YX
Pang
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. yangquan7208@vip.163.com.
Zuo-Wang
ZW
Fan
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. wang_dan1414@163.com.
Dan
D
Wang
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China. yangquan7208@vip.163.com.
Quan
Q
Yang
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. jimojijie29@163.com.
Kai
K
Wang
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. hillowchan@hotmail.com.
Xiao-Lu
XL
Chen
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. mchuxuan@163.com.
Xuan
X
Hu
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. fulai.yu@163.com.
Fu-Lai
FL
Yu
Tropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Danzhou 571737, Hainan, China. 18889584013@126.com.
Zhen-Xia
ZX
Chen
D000287:Administration, Topical; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D015415:Biomarkers / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D009822:Oils, Volatile / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014947:Wounds and Injuries / Q000097:blood / Q000188:drug therapy*
D015415:Biomarkers; D009822:Oils, Volatile