Transition-metal-free direct alkylation of aryl tetrazoles via intermolecular oxidative C-N formation.
A transition-metal-free synthetic approach for constructing alkylated aryl tetrazoles has been developed using n-Bu4NI as the catalyst and t-BuOOH as the oxidant. It involves the direct C-N bond formation through sp(3) C-H activation. A wide range of benzylic C-H substrates (or alkyl ethers) and aryl tetrazoles undergo this reaction smoothly to deliver the corresponding products in good yields.
School of Petrochemical Engineering and Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University , Changzhou, 213164, P. R. China.
Liang
L
Wang
Kaiqiang
K
Zhu
Qun
Q
Chen
Mingyang
M
He
D000478:Alkylation; D001593:Benzyl Compounds / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
D001593:Benzyl Compounds; D008670:Metals; D016877:Oxidants; D013777:Tetrazoles; D028561:Transition Elements