"Comparative efficacy of different doses of fentanyl on cardiovascular responses to laryngoscopy and tracheal intubation".
BACKGROUND
This study was conducted to determine an effective bolus dose of fentanyl, which would attenuate the cardiovascular response to laryngoscopy and tracheal intubation.


METHODS
A randomised double blind controlled study was carried out on 50 healthy adult patients (ASA I and II) undergoing elective surgery under general anaesthesia. The patients were randomly allocated into two groups of 25 each i.e. group A and group B receiving fentanyl 3 μg/kg, 5 μg/kg intravenously three minutes before intubation respectively. The pulse rate, systolic blood pressure was recorded at induction, during intubation and at 1,3, 5 min post intubation.


RESULTS
The study showed that both the doses were equally effective in blunting the pulse rate response, but the 5μg /kg proved significantly effective in blunting the blood pressure response. The rate pressure product, a measure of cardiac O2 consumption was found to be significantly lower in fentanyl 5μg/kg compared to fentanyl 3μg/kg.


CONCLUSIONS
So, we conclude that both blood pressure and rate pressure product were completely abolished by a bolus dose of fentanyl 5μg /kg in comparison with fentanyl 3μg/kg following laryngoscopy and intubation.
Associate Professor, Affiliated to Department of Anesthesiology, S N Medical College , Bagalkot, Karnataka India .
Vinod
V
Hosalli
Assist Professor, Affiliated to Department of Anesthesiology, S N Medical College , Bagalkot, Karnataka India .
Adarsh
A
Es
Professor, Affiliated to Department of Anesthesiology, S N Medical College , Bagalkot, Karnataka India .
S Y
SY
Hulkund
Associate Professor, Affiliated to Department of Anesthesiology, S N Medical College , Bagalkot, Karnataka India .
Chhaya
C
Joshi
Cardiovascular response; Fentanyl; Pulse rate