Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A.
The T118M mutation in PMP22 gene is associated with Charcot Marie Tooth, type 1A (CMT1A). CMT1A is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Mutations in CMT related disorder are seen to increase the stability of the protein resulting in the diseased state. We performed SNP analysis for all the nsSNPs of PMP22 protein and carried out molecular dynamics simulation for T118M mutation to compare the stability difference between the wild type protein structure and the mutant protein structure. The mutation T118M resulted in the overall increase in the stability of the mutant protein. The superimposed structure shows marked structural variation between the wild type and the mutant protein structures.
School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India.
Chundi Vinay
0000-0002-5569-9336
CV
Kumar
School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India.
Rayapadi G
RG
Swetha
School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu 632014, India.
Anand
0000-0003-2216-7488
A
Anbarasu
Bioinformatics Division, School of Biosciences & Technology (SBST), VIT University, Vellore 632014, India.
Sudha
0000-0002-4800-329X
S
Ramaiah