Significance and biological importance of pyrimidine in the microbial world.
Microbes are unique creatures that adapt to varying lifestyles and environment resistance in extreme or adverse conditions. The genetic architecture of microbe may bear a significant signature not only in the sequences position, but also in the lifestyle to which it is adapted. It becomes a challenge for the society to find new chemical entities which can treat microbial infections. The present review aims to focus on account of important chemical moiety, that is, pyrimidine and its various derivatives as antimicrobial agents. In the current studies we represent more than 200 pyrimidines as antimicrobial agents with different mono-, di-, tri-, and tetrasubstituted classes along with in vitro antimicrobial activities of pyrimidines derivatives which can facilitate the development of more potent and effective antimicrobial agents.
School of Pharmacy, Lloyd Institute of Management & Technology, Plot. No. 11, Knowledge Park II, Greater Noida, Uttar Pradesh 201306, India.
Vinita
V
Sharma
Bioinformatics Centre, Biotech Park, Sector G, Jankipuram, Lucknow, Uttar Pradesh 226021, India ; Gautam Buddh Technical University, IET Campus, Sitapur Road, Lucknow, Uttar Pradesh 226021, India.
Nitin
0000-0002-1322-5861
N
Chitranshi
Department of Pharmaceutical Sciences, University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana 136119, India.
Ajay Kumar
AK
Agarwal