Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy.
We present a case of rhino-orbitary mucormycosis which progressed despite liposomal amphotericin and early surgical debridement. Combined echinocandin and high dose liposomal amphotericin, repeated debridement, prolonged therapy with hyperbaric oxygen and continued therapy with posaconazole, along with strict diabetic control, allowed cure without disfigurement.
Dermatology Department, Hospital Severo Ochoa, Avenida Orellana, 28911 Leganés, Madrid, Spain.
Adrián
A
Imbernón
Internal Medicine Department, Hospital Severo Ochoa, Avenida Orellana, 28911 Leganés, Madrid, Spain.
José Luis
JL
Agud
Microbiology Department, Hospital Severo Ochoa, Avenida Orellana, 28911 Leganés, Madrid, Spain.
María Soledad
MS
Cuétara
Otolaryngology Department, Hospital Severo Ochoa, Avenida Orellana, 28911 Leganés, Madrid, Spain.
José Carlos
JC
Casqueiro
Radiology Department, Hospital Severo Ochoa, Avenida Orellana, 28911 Leganés, Madrid, Spain.
Pilar
P
Nuñez
Internal Medicine Department, Hospital Central de la Defensa, Glorieta del Ejército 1, 28047 Madrid, Spain.
Alegría R
AR
Domínguez
Otolaryngology Department, Hospital Central de la Defensa, Glorieta del Ejército 1, 28047 Madrid, Spain.
Eusebio
E
Bullido
Unitat de Microbiología, Facultat de Medicina I Ciencies de la Salut, Universitat Rovira I Virgili, Reus, Spain.
Alberto M
AM
Stchigel
Amphotericin B; Diabetes mellitus; Hyperbaric oxygen; Posazonale; Rhizopus arrhizu; Zygomycosis