Phosphatase Wip1 as a new therapeutic target for intestinal ischemia-reperfusion injury.
Intestinal ischemia/reperfusion (I/R) injury is a pathophysiology involving local tissue injury and organ dysfunction. Accumulating evidence has confirmed that the infiltration of neutrophils is of central importance in mediating intestinal I/R injury. On the other hand, adequate neutrophils in the intestine could also benefit the antibacterial translocation and tissue repair. Consequently, regulation of neutrophil immunity after intestinal I/R might be a promising therapy for controlling intestinal injury. Wip1 is a serine/threonine protein phosphatase that acts as the master regulator of tumorigenesis. However, emerging evidence highlights the importance of Wip1 in regulating neutrophil development, maturation, migration and neutrophil pro-inflammatory cytokine productions. Our recent studies showed that Wip1 negatively regulates neutrophil inflammatory responses and plays a protective role in intestinal I/R injury. In light of this discovery, we believe that Wip1 might be a new therapeutic target for treating intestinal I/R injury.
Department of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Xiaofei
X
Shen
Junfeng
J
Du
Yong
Y
Zhao
Wenxian
W
Guan
D000818:Animals; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology / Q000378:metabolism; D007410:Intestinal Diseases / Q000276:immunology / Q000378:metabolism*; D007422:Intestines / Q000098:blood supply; D007960:Leukocyte Disorders / Q000276:immunology / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000276:immunology / Q000378:metabolism*; D000071636:Protein Phosphatase 2C; D015427:Reperfusion Injury / Q000276:immunology / Q000378:metabolism*
C000607458:PPM1D protein, human; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C
Wip1; intestinal ischemia/reperfusion injury; neutrophils