Dendrimeric calcium-responsive MRI contrast agents with slow in vivo diffusion.
We report a methodology which enables the preparation of dendrimeric contrast agents sensitive to Ca(2+) when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaking synthetic transformations, despite structural changes. The in vivo MRI studies in the rat cerebral cortex indicate that diffusion properties of dendrimeric contrast agents have great advantages as compared to their monomeric equivalents.
MR Neuroimaging Agents Group, Max Planck Institute for Biological Cybernetics, 72076 Tübingen, Germany. goran.angelovski@tuebingen.mpg.de.
Serhat
S
Gündüz
Nobuhiro
N
Nitta
Sandip
S
Vibhute
Sayaka
S
Shibata
Martin E
ME
Mayer
Nikos K
NK
Logothetis
Ichio
I
Aoki
Goran
G
Angelovski
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D004058:Diffusion; D008279:Magnetic Resonance Imaging; D051381:Rats
D003287:Contrast Media; D050091:Dendrimers; D002118:Calcium