Intrafollicular classical Hodgkin lymphoma mimicking nodular lymphocyte predominant Hodgkin lymphoma: a report of two cases.
We here report on two rare cases of intrafollicular classical Hodgkin lymphoma (CHL). Case 1 was a 34-year-old man who underwent left supraclavicular lymph node biopsy. Case 2 was a 28-year-old woman who underwent surgical resection of an anterior mediastinal mass. The histology and microenvironment of both specimens resembled those of nodular lymphocyte predominant Hodgkin lymphoma. Nodular architecture was observed, which comprised normal-appearing small lymphocytes and scattered lymphocyte predominant (LP)-like cells. CD23(+) follicular dendritic cell meshworks were present in the nodules, surrounded by a mantle zone containing IgD(+) B cells. The LP-like cells were ringed by CD3(+) and PD-1(+) T cells, and numerous CD20(+) B cells were present in the background. However, the immunophenotypes of the LP-like cells resembled those of Hodgkin/Reed-Sternberg cells of CHL; they were positive for CD15, CD30, and PAX5, and negative for CD20, Bcl6, Oct2, and Bob1. These histopathological findings indicate that CHL can be derived from the germinal center.
Department of Pathology, National Cancer Center Hospital, Tokyo, Japan; Department of Hematology, National Cancer Center Hospital, Tokyo, Japan.
Mai
M
Tatsuno
Akiko Miyagi
AM
Maeshima
Sung-Won
SW
Kim
Dai
D
Maruyama
Hirokazu
H
Taniguchi
Ken-ichi
K
Miyamoto
Suguru
S
Fukuhara
Yukio
Y
Kobayashi
Kensei
K
Tobinai
Ryoji
R
Kushima
D000328:Adult; D005260:Female; D018858:Germinal Center / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008297:Male
classical Hodgkin lymphoma; germinal center; immunohistochemistry; nodular lymphocyte predominant Hodgkin lymphoma