The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.
Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.
Department of Microbiology and Immunology, the Lineberger Comprehensive Cancer Center and the Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Manira
M
Rayamajhi
Department of Microbiology and Immunology, the Lineberger Comprehensive Cancer Center and the Center for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Edward A
EA
Miao
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D012327:RNA Virus Infections / Q000276:immunology*; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C492716:Nlrp3 protein, mouse; D053422:Receptor-Interacting Protein Serine-Threonine Kinases