Cell-penetrating poly(disulfide)s: the dependence of activity, depolymerization kinetics and intracellular localization on their length.
We report that the depolymerization kinetics of cell-penetrating poly(disulfide)s depend exclusively on their length and propose a kinetic uptake model to explain why their intracellular destination changes with the increasing length from the endosomes over the cytosol to the nucleoli.
School of Chemistry and Biochemistry, University of Geneva, Geneva, Switzerland. stefan.matile@unige.ch.
Nicolas
N
Chuard
Giulio
G
Gasparini
Aurélien
A
Roux
Naomi
N
Sakai
Stefan
S
Matile
D001692:Biological Transport; D004220:Disulfides / Q000737:chemistry* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism*; D007700:Kinetics; D058105:Polymerization
D004220:Disulfides