[Incidence and factors influencing oral mucositis in patients with hematopoietic stem cell transplantation].
OBJECTIVE
This study was done to examine the incidence of oral mucositis in hematopoietic stem cell transplantation patients and to identify factors influencing oral mucositis and patient outcomes according to severity.


METHODS
In this retrospective study, data were collected from electronic medical records of 222 patients who had received hematopoietic stem cell transplantation. Oral mucositis was evaluated using WHO's assessment scale. Data were analyzed using Chi-square test, Fisher exact test, Spearman's correlation, Ordinal logistic regression, ANOVA and Kruskal-Wallis test.


RESULTS
A total of 69.8% of the patients evaluated developed oral mucositis (grade II and over). As a results of ordinal regression, factors influencing oral mucositis severity were found to be diagnosis, type of transplantation, oxygen inhalation and the number of antiemetics administration before transplantation. The severity of oral mucositis was found to increase the days of hospitalization, days of TPN administration, days of using antibiotics and the number and dosage of analgesics.


CONCLUSIONS
The results would help predict severity of oral mucositis in hematopoietic stem cell transplantation patients and suggest that provision of appropriate nursing assessment and oral care would improve patient outcomes.
Graduate School, The Catholic University of Korea, Seoul, Korea.
Kwan Suk
KS
Jo
College of Nursing, The Catholic University of Korea, Seoul, Korea. kncpjo@catholic.ac.kr.
Nam Cho
NC
Kim
D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015992:Body Mass Index; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D007938:Leukemia / Q000628:therapy; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D010289:Parenteral Nutrition, Total; D011829:Radiation Dosage; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013280:Stomatitis / Q000453:epidemiology* / Q000473:pathology / Q000517:prevention & control; D055815:Young Adult
D000700:Analgesics; D000900:Anti-Bacterial Agents
Hematopoietic stem cells; Mucositis; Transplantation