Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice.
In order to promote preclinical and clinical applications of photoacoustic imaging, novel photoacoustic contrast agents are highly desired for molecular imaging of diseases, especially for deep tumor imaging. Here, perylene-3,4,9,10-tetracarboxylic diiimide-based near-infrared-absorptive organic nanoparticles are reported as an efficient agent for photoacoustic imaging of deep brain tumors in living mice with enhanced permeability and retention effect.
Key Laboratory for Organic Electronics & Information Displays and Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing, 210046, China; Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, California, 94305-5484, USA.
Quli
Q
Fan
Kai
K
Cheng
Zhen
Z
Yang
Ruiping
R
Zhang
Min
M
Yang
Xiang
X
Hu
Xiaowei
X
Ma
Lihong
L
Bu
Xiaomei
X
Lu
Xiaoxing
X
Xiong
Wei
W
Huang
Heng
H
Zhao
Zhen
Z
Cheng
D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis*; D002470:Cell Survival / Q000187:drug effects; D003287:Contrast Media / Q000737:chemistry / Q000633:toxicity; D003952:Diagnostic Imaging / Q000379:methods*; D007094:Imides / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D008823:Micelles; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000633:toxicity; D010569:Perylene / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D061088:Photoacoustic Techniques / Q000379:methods*
D003287:Contrast Media; D007094:Imides; D008823:Micelles; C521332:perylenediimide; D010569:Perylene
Perylene-3,4,9,10-tetracarboxylic diimide nanoparticles; brain tumor; deep tumor imaging; near-infrared-absorption; photoacoustic imaging