Comparison of dual-energy X-ray absorptiometry with six quantitative ultrasonometry devices in women with hip fractures.
OBJECTIVE
Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessment of bone mineral density, an important risk factor for osteoporotic fractures. Recent reports suggest that quantitative ultrasonometry (QUS) is able to predict fractures; however, only limited data in women with hip fractures are available.


METHODS
We examined 91 postmenopausal women who had sustained an osteoporosis-related hip fracture within the past 7 days using DXA and six different QUS devices and compared them with 91 healthy age-matched controls.


RESULTS
Femoral neck (FN), total hip (TH) and lumbar spine (LS) T-scores were lower in women with hip fractures compared to matched controls: - 2.38 vs. - 1.64 (p < 0.001), - 2.36 vs. - 1.44 (p < 0.001) and - 2.05 vs. - 1.50 (p = 0.41), respectively. The T-scores of the Achilles, Sahara, InSight and Omnisence QUS devices were also lower in patients with hip fractures compared to matched controls: - 3.20 vs. - 2.36 (p < 0.001), - 2.196 vs. - 1.761 (p = 0.005), - 2.631 vs. - 1.849 (p < 0.001), - 3.707 vs. - 3.030 (p = 0.032), respectively. However, the T-scores of the DBM and QUS-2 did not differ between the two groups: - 4.543 vs. - 4.324 (p = 0.352) and - 1.7 vs. - 2.0 (p = 0.465), respectively. Compared to DXA (hip), the odds ratios of the Achilles, InSight and Sahara were comparable, while the odds ratios of the DBM, Omnisence and QUS-2 were significantly lower (p ≤ 0.05).


CONCLUSIONS
Compared to DXA, the Achilles, Sahara and InSight QUS devices showed similar hip fracture discrimination while the DBM, Omnisence and QUS-2 did not. Therefore, some QUS devices are able to identify a clinically meaningful risk factor in women at high risk of hip fracture.
Department of Osteooncology, Gynecological Endocrinology and Reproductive Medicine, Nord-West Hospital , Frankfurt , Germany.
P
P
Hadji
P
P
Imani
C
C
Wüster
O
O
Hars
U-S
US
Albert
I
I
Kyvernitakis
D015502:Absorptiometry, Photon / Q000379:methods*; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006620:Hip Fractures / Q000000981:diagnostic imaging*; D006801:Humans; D016017:Odds Ratio; D058866:Osteoporotic Fractures / Q000150:complications*; D017698:Postmenopause; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods*
BONE MINERAL DENSITY; DXA; HIP FRACTURE; OSTEOPOROSIS; QUANTITATIVE ULTRASONOMETRY