Palladium-catalyzed sequential C-N/C-O bond formations: synthesis of oxazole derivatives from amides and ketones.
A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd(II)-catalyzed sp(2) C-H activation pathway in one step. The reaction is supposed to proceed through a C-N bond formation followed by a C-O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly applied to medical chemistry.
School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
Meifang
M
Zheng
Liangbin
L
Huang
Huawen
H
Huang
Xianwei
X
Li
Wanqing
W
Wu
Huanfeng
H
Jiang