Fatal diphenhydramine poisoning in a dog.
We report a fatal diphenhydramine poisoning of a 10-year-old, male poodle-cross dog with pre-existing conditions and suspected co-ingestion of ethanol. This case illustrates that diphenhydramine overdose can be fatal in certain circumstances and that analytical toxicology may play an important role in animal death investigations.
Diagnostic Center for Population and Animal Health, Toxicology Section, Michigan State University, 4125 Beaumont Road, Lansing, Michigan 48910 USA (Buchweitz, Johnson, Lehner); Animal Health Centre, British Columbia Ministry of Agriculture, 1767 Angus Campbell Road, Abbotsford, British Columbia V3G 2M3 (Raverty).
John P
JP
Buchweitz
Diagnostic Center for Population and Animal Health, Toxicology Section, Michigan State University, 4125 Beaumont Road, Lansing, Michigan 48910 USA (Buchweitz, Johnson, Lehner); Animal Health Centre, British Columbia Ministry of Agriculture, 1767 Angus Campbell Road, Abbotsford, British Columbia V3G 2M3 (Raverty).
Stephen A
SA
Raverty
Diagnostic Center for Population and Animal Health, Toxicology Section, Michigan State University, 4125 Beaumont Road, Lansing, Michigan 48910 USA (Buchweitz, Johnson, Lehner); Animal Health Centre, British Columbia Ministry of Agriculture, 1767 Angus Campbell Road, Abbotsford, British Columbia V3G 2M3 (Raverty).
Margaret B
MB
Johnson
Diagnostic Center for Population and Animal Health, Toxicology Section, Michigan State University, 4125 Beaumont Road, Lansing, Michigan 48910 USA (Buchweitz, Johnson, Lehner); Animal Health Centre, British Columbia Ministry of Agriculture, 1767 Angus Campbell Road, Abbotsford, British Columbia V3G 2M3 (Raverty).
Andreas F
AF
Lehner
D000818:Animals; D003937:Diagnosis, Differential; D004155:Diphenhydramine / Q000506:poisoning*; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs; D062787:Drug Overdose / Q000662:veterinary; D000431:Ethanol / Q000506:poisoning*; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D008297:Male
D006634:Histamine H1 Antagonists; D000431:Ethanol; D004155:Diphenhydramine