A new turn-on chemosensor for bio-thiols based on the nanoaggregates of a tetraphenylethene-coumarin fluorophore.
In this work, a tetraphenylethene-coumarin hybrid fluorophore (TPE-Cou) that contains a Schiff base form is designed and synthesized. A combination of plentiful optical properties and chemical reactivity towards thiols allows TPE-Cou to work as an excellent turn-on probe of thiols with a wide linear range, revealing the great potential of this dye as a quantitative fluorescence indicator. By means of NMR and optical spectrum analyses, a mechanistic picture at the molecular level has been drawn to illustrate how this dye works as a bio-thiol-sensitive fluorescent probe.
Key Laboratory for Large-Format Battery Materials and System, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. xiafan@hust.edu.cn.
Xiaoding
X
Lou
Zujin
Z
Zhao
Yuning
Y
Hong
Chao
C
Dong
Xuehong
X
Min
Yuan
Y
Zhuang
Xuemei
X
Xu
Yongmei
Y
Jia
Fan
F
Xia
Ben Zhong
BZ
Tang
D003374:Coumarins / Q000737:chemistry*; D005030:Ethylenes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000032:analysis / Q000138:chemical synthesis*; D008956:Models, Chemical; D008958:Models, Molecular; D058726:Nanoconjugates / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry
D003374:Coumarins; D005030:Ethylenes; D005456:Fluorescent Dyes; D058726:Nanoconjugates; D013438:Sulfhydryl Compounds; C030123:coumarin