Evaluating 3D-printed biomaterials as scaffolds for vascularized bone tissue engineering.
There is an unmet need for a consistent set of tools for the evaluation of 3D-printed constructs. A toolbox developed to design, characterize, and evaluate 3D-printed poly(propylene fumarate) scaffolds is proposed for vascularized engineered tissues. This toolbox combines modular design and non-destructive fabricated design evaluation, evaluates biocompatibility and mechanical properties, and models angiogenesis.
Fischell Department of Bioengineering, 3238 Jeong H. Kim Engineering Building, University of Maryland, College Park, MD, USA.
Martha O
MO
Wang
Charlotte E
CE
Vorwald
Maureen L
ML
Dreher
Eric J
EJ
Mott
Ming-Huei
MH
Cheng
Ali
A
Cinar
Hamidreza
H
Mehdizadeh
Sami
S
Somo
David
D
Dean
Eric M
EM
Brey
John P
JP
Fisher
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001842:Bone and Bones / Q000098:blood supply / Q000502:physiology*; D005650:Fumarates / Q000737:chemistry; D021621:Imaging, Three-Dimensional; D008422:Materials Testing / Q000379:methods*; D008954:Models, Biological; D018919:Neovascularization, Physiologic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011126:Polypropylenes / Q000737:chemistry; D016062:Porosity; D066330:Printing, Three-Dimensional; D017207:Rats, Sprague-Dawley; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography
D001672:Biocompatible Materials; D005650:Fumarates; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011126:Polypropylenes; C097850:poly(propylene fumarate)
3D printing; scaffolds; tissue engineering; vascularization