Correlation between reduction of superior interventricular groove epicardial fat thickness and improvement of insulin resistance after weight loss in obese men.
BACKGROUND
It has been recognized that reduction of abdominal visceral fat and subcutaneous fat are associated with improvement in insulin-resistance (IR) after weight loss. However, few studies have investigated the correlation of reduction in epicardial adipose tissue (EAT) with improvement of IR index after weight loss in obese non-diabetic men with metabolic syndrome (MetS).


RESULTS
We prospectively enrolled 32 non-diabetic men with MetS for a 3-month weight reduction program mainly by diet control and exercise. Magnetic resonance imaging (MRI) examinations were used to measure EAT, subcutaneous fat, and abdominal visceral fat. Anthropometric parameters, oral glucose tolerance test (OGTT), and serum adipokines were assessed before and after the weight loss program. After a 3-month weight loss program, 27 obese MetS men had significant weight loss >5% (97 ± 14 to 87 ± 14 kg, with a 10.7 % decrease, p < 0.001). Multivariate analysis revealed that the decrement ratio of superior interventricular groove (SIVG) EAT thickness (r = 0.322, p = 0.044) and serum leptin (r = 0.626, p < 0.001) significantly correlated with the percentage improvements of fasting HOMA-IR index. Furthermore, the decrement ratio of SIVG EAT thickness (r = -0.370, p = 0.017) and decrement ratio of subcutaneous fat area (r = -0.673, p = 0.006) were significantly correlated with improvement of OGTT-derived Matsuda insulin-sensitivity index.


CONCLUSIONS
The decrement ratio of SIVG EAT correlated with improvement of both HOMA-IR and OGTT-derived Matsuda insulin-sensitivity indexes after weight loss in obese non-diabetic men with MetS.


BACKGROUND
(Multi-faceted Evaluations Following Weight Reduction in Subjects with Metabolic Syndrome NCT 01065753 on Feb 8, 2010).
Cardiovascular Center, Taichung Veterans General Hospital, No.1650 Section 4, Taiwan Boulevard, Taichung, 40705 Taiwan ; Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
Kae-Woei
KW
Liang
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan ; Department of Medical Imaging, Show Chwan Memorial Hospital, Changhua, Taiwan ; Department of Medical Imaging, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan.
I-Chen
IC
Tsai
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan ; Tung-Hai University, Taichung, Taiwan.
Wen-Jane
WJ
Lee
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Shih-Yi
SY
Lin
Cardiovascular Center, Taichung Veterans General Hospital, No.1650 Section 4, Taiwan Boulevard, Taichung, 40705 Taiwan ; Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan.
Wen-Lieng
WL
Lee
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
I-Te
IT
Lee
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Chia-Po
CP
Fu
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Jun-Sing
JS
Wang
Cardiovascular Research Center, Department of Radiology and Department of Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan ; Department of Medicine, Chung Shan Medical University, Taichung, Taiwan ; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan ; Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan ; Taichung Veterans General Hospital, No.1650 Section 4, Taiwan Boulevard, Taichung, 40705 Taiwan.
Wayne H-H
WH
Sheu
Epicardial adipose tissue; Insulin resistance; Leptin; Matsuda index; Metabolic syndrome; Obesity