Evaluation of the Etoricoxib-Mediated Pain-Relieving Effect in Patients Undergoing Lumbar Fusion Procedures for Degenerative Lumbar Scoliosis: A Prospective Randomized, Double-Blind Controlled Study.
This randomized, double-blind study was carried out to evaluate the effectiveness of etoricoxib in controlling the pain during lumbar fusion surgery of the degenerative lumbar scoliosis patients. We found that perioperative use of etoricoxib produced a significant reduction in the degree of pain compared to the patients treated with placebo. Etoricoxib eased the pain and helped to manage the discomfort of lumbar fusion surgery. In addition, etoricoxib was well tolerated as it caused no serious adverse reaction, suggesting a safe profile. Etoricoxib also appeared to ensure and promote the positive effect of surgery, however, insignificantly. Thus, the results suggest that etoricoxib was effective in safely managing the pain during the lumbar fusion surgery and recovery thereafter.
Department of Orthopaedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China.
Yongxiang
Y
Shi
International Health Care Center, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China.
Ping
P
Wang
Department of Orthopaedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China.
Xinlei
X
Hu
Department of Orthopaedic Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jie Fang Road, Hangzhou, 310009, China. drzhaomingye@126.com.
Zhaoming
Z
Ye
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D000077613:Etoricoxib; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000150:complications*; D008159:Lumbar Vertebrae / Q000601:surgery*; D008875:Middle Aged; D059408:Pain Management / Q000009:adverse effects / Q000379:methods*; D019990:Perioperative Care; D011446:Prospective Studies; D011725:Pyridines / Q000009:adverse effects / Q000494:pharmacology*; D012600:Scoliosis / Q000150:complications* / Q000601:surgery*; D013123:Spinal Fusion / Q000009:adverse effects*; D013450:Sulfones / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors; D055815:Young Adult
D011725:Pyridines; D013450:Sulfones; D000077613:Etoricoxib
Degenerative lumbar scoliosis; Etoricoxib; Fusion procedures; Non-steroidal anti-inflammatory agents