Molecular insights into how ligands activate or inactivate LasR.
The article by Gerdt and colleagues in this issue of Chemistry & Biology provides molecular insights into how nonlactone quorum sensing modulators either activate or deactivate LasR. Interestingly, an antagonist could flip into an agaonist upon mutation of a single residue in the autoinducer binding site.
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
Yue
Y
Zheng
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. Electronic address: hsintim@umd.edu.
Herman O
HO
Sintim
D000813:Anilides / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D044482:Benzeneacetamides / Q000378:metabolism*; D008024:Ligands; D015534:Trans-Activators / Q000378:metabolism*
D000813:Anilides; D001426:Bacterial Proteins; D044482:Benzeneacetamides; D008024:Ligands; D015534:Trans-Activators