SWI/SNF proteins as targets in cancer therapy.
Recent identification of synthetic lethal interactions involving several proteins of the SWI/SNF complex discussed in this Research Highlight has opened the possibility of new cancer therapeutic approaches.
GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. santiago.schiaffino@genyo.es.
Santiago
S
Schiaffino-Ortega
GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. Carlos.balinas@genyo.es.
Carlos
C
Balinas
Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain. marta.cuadros@genyo.es.|GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. marta.cuadros@genyo.es.
Marta
M
Cuadros
Department of Biochemistry and Molecular Biology, University of Granada, Granada, Spain. pedromedina@ugr.es.|GENyO, Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, Spain. pedromedina@ugr.es.
Pedro P
PP
Medina
D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000628:therapy*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D002868:Chromosomal Proteins, Non-Histone; D014157:Transcription Factors