The polymorphic phase transformations in the chlorpropamide under pressure.
The crystal structure and vibrational spectra of the chlorpropamide have been studied by means of the X-ray diffraction and Raman spectroscopy at pressures up to 24.6 and 4.4 GPa, respectively. Two polymorphic phase transitions, between initial orthorhombic form-A and a monoclinic form-AI at P ∼ 1.2 GPa and, in additional, to another monoclinic form-AII at P ∼ 3.0 GPa, were observed. At pressures above 9.6 GPa, a transformation to the amorphous phase of chlorpropamide was revealed. The lattice parameters, unit cell volumes, and vibration modes as functions of pressure were obtained for the different polymorphic modifications of chlorpropamide.
Frank Laboratory of Neutron Physics, JINR, Dubna, 141980, Moscow Region, Russia.
Sergey E
SE
Kichanov
Denis P
DP
Kozlenko
Jan
J
Wąsicki
Wojciech
W
Nawrocik
Leonid S
LS
Dubrovinsky
Hanns-Peter
HP
Liermann
Wolfgang
W
Morgenroth
Boris N
BN
Savenko
D000465:Algorithms; D002747:Chlorpropamide / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004339:Drug Compounding; D004355:Drug Stability; D007004:Hypoglycemic Agents / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D044367:Phase Transition; D011312:Pressure / Q000009:adverse effects; D013059:Spectrum Analysis, Raman
D007004:Hypoglycemic Agents; D002747:Chlorpropamide
Raman spectroscopy; X-ray powder diffractometry; amorphous; crystal structure; polymorphism