Cochlearols A and B, polycyclic meroterpenoids from the fungus Ganoderma cochlear that have renoprotective activities.
(+)- and (-)-cochlearols A (1) and B (2), two meroterpenoids with novel polycyclic skeletons, were isolated from the fruiting bodies of the fungus Ganoderma cochlear. Their structures and stereochemistry were determined by using spectroscopic, computational and single-crystal X-ray diffraction methods. Cochlearol A is a new normeroterpenoid containing a naturally unusual dioxaspiro[4.5]decane motif. Biological studies showed that (-)-2 is a strong inhibitor of p-Smads, exhibiting renoprotective activities in TGF-β1 induced rat renal proximal tubular cells.
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.|§Faculty of Life Science and Technology, Kunming University of Science of Technology, Kunming 650500, P. R. China.
Man
M
Dou
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.
Lei
L
Di
‡State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China.
Li-Li
LL
Zhou
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.|∥University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, P. R. China.
Yong-Ming
YM
Yan
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.
Xin-Long
XL
Wang
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.
Feng-Jiao
FJ
Zhou
⊥Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
Zhu-Liang
ZL
Yang
§Faculty of Life Science and Technology, Kunming University of Science of Technology, Kunming 650500, P. R. China.
Rong-Tao
RT
Li
‡State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, P. R. China.
Fan-Fan
FF
Hou
†State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, 132 Lanhei Road, Kunming 650201, P. R. China.
Yong-Xian
YX
Cheng
D000818:Animals; D002681:China; D018360:Crystallography, X-Ray; D032902:Ganoderma / Q000737:chemistry*; D007668:Kidney / Q000187:drug effects*; D008968:Molecular Conformation; D015394:Molecular Structure; D051381:Rats; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1 / Q000187:drug effects
D013729:Terpenes; D053773:Transforming Growth Factor beta1; C000596515:cochlearol A; C000596516:cochlearol B