[Interplay between primary cilia and cell cycle].
The primary cilium is often associated with the phases G0 and G1 of the cellular cycle in most of the cells. So, recent studies show that its formation and its resorption are closely linked to molecular actors of the cellular cycle, as for example Aurora A or PLK1 (polo-like kinase 1). Furthermore, its resorption seems to be critical for the progress of the phase S and the cellular determination, in particular in the case of neural stem cells. Finally, the primary cilium acts as a cellular antenna allowing to transmit numerous signal pathways which, in their turn, contribute to the cellular fate.
Institut de biologie de l'École normale supérieure (IBENS), 46, rue d'Ulm, 75005 Paris, France - Inserm U1024, 75005 Paris, France - CNRS UMR 8197, 75005 Paris, France.
Nathalie
N
Delgehyr
Institut de biologie de l'École normale supérieure (IBENS), 46, rue d'Ulm, 75005 Paris, France - Inserm U1024, 75005 Paris, France - CNRS UMR 8197, 75005 Paris, France.
Nathalie
N
Spassky
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D002923:Cilia / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008322:Mammals; D008954:Models, Biological; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology
D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D011494:Protein Kinases