Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions.
This study was to investigate the utility of platelet-derived microparticles (PMPs) to detect coronary intermediate lesions. Fifty-two patients with coronary intermediate lesions and 24 subjects with normal coronary arteries were enrolled. In the former group, 31 patients accepted both intravenous ultrasound (IVUS) and fractional flow reserve (FFR). Results showed that the level of PMPs was significantly higher in the intermediate lesion group and PMPs titer was positively correlated with thromboxane B2, platelet activating factor, endothelin-1, and neutrophil to lymphocyte ratio. The level of PMPs also increased after IVUS/FFR, suggesting platelet activation and endothelial dysfunction.
Department of Cardiology, Peking University Third Hospital , Beijing , China .
Yuan I Scarlet
YI
Chou
Jinge
J
Kong
Rui
R
Song
Lulu
L
Yan
Lemin
L
Zheng
Yongzhen
Y
Zhang
D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000378:metabolism* / Q000473:pathology; D019332:Endothelin-1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology*; D010972:Platelet Activating Factor / Q000378:metabolism*; D015539:Platelet Activation; D013929:Thromboxane B2 / Q000378:metabolism*
D015415:Biomarkers; D019332:Endothelin-1; D010972:Platelet Activating Factor; D013929:Thromboxane B2
Coronary heart disease; coronary intermediate lesion; fractional flow reserve; intravenous ultrasound; platelet-derived microparticles