Synergistic effects of neck circumference and metabolic risk factors on insulin resistance: the Cardiometabolic Risk in Chinese (CRC) study.
OBJECTIVE
Recent studies have associated neck circumference (NC) with insulin resistance (IR). We examined whether such relation was modified by other metabolic risk factors.


METHODS
The study samples were from a community-based health examination survey in central China. A total of 2588 apparently healthy Chinese men and women were included.


RESULTS
Plasma levels of total cholesterol (TC), HDL-C, uric acid (UA) and diastolic blood pressure (DBP) were independently associated with NC after adjusted for age, sex, body mass index (BMI), waist circumference (WC) and hip circumference (HC) (P = 0.009, 0.001, 0.015 and 0.015, respectively). We observed significant interactions of NC with triglyceride (TG) and UA (all the p for interaction = 0.001) in relation to HOMA-IR. It appeared that the associations between NC and HOMA-IR were more evident in those with higher UA or TG level.


CONCLUSIONS
Our data indicate that in apparently healthy Chinese adults, there were synergistic effects of UA, TG and neck circumference on insulin resistance.
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Jun
J
Liang
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Fei
F
Teng
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Xuekui
X
Liu
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Caiyan
C
Zou
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Yu
Y
Wang
Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College; Affiliated Hospital of Southeast University, 199# South Jiefang Road, Xuzhou, 221009 Jiangsu China.
Lianjun
L
Dou
Institute of diabetes, Medical School, Southeast University, Nanjing, 210009 Jiangsu China.
Zilin
Z
Sun
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115 USA ; Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115 USA.
Lu
L
Qi
Insulin resistance; Neck circumference; Synergistic effects; Triglyceride; Uric acid