The role of ERK5 in endothelial cell function.
Extracellular-signal-regulated kinase 5 (ERK5), also termed big MAPK1 (BMK1), is the most recently discovered member of the mitogen-activated protein kinase (MAPK) family. It is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. In vitro studies have revealed that, in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling and regulating tumour angiogenesis. The present review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.
*MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
Gopika N
GN
Nithianandarajah-Jones
†Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
Bettina
B
Wilm
*MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
Christopher E P
CE
Goldring
‡Warwick Medical School, University of Warwick, Coventry CV4 7AL, U.K.
Jürgen
J
Müller
*MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool L69 3GE, U.K.
Michael J
MJ
Cross
D004730:Endothelium, Vascular / Q000201:enzymology* / Q000502:physiology; D006801:Humans; D048054:Mitogen-Activated Protein Kinase 7 / Q000378:metabolism*
D048054:Mitogen-Activated Protein Kinase 7