Periodontal innate immune mechanisms relevant to atherosclerosis.
Atherosclerosis is a common cardiovascular disease in the USA where it is a leading cause of illness and death. Atherosclerosis is the most common cause for heart attack and stroke. Most commonly, people develop atherosclerosis as a result of diabetes, genetic risk factors, high blood pressure, a high-fat diet, obesity, high blood cholesterol levels, and smoking. However, a sizable number of patients suffering from atherosclerosis do not harbor the classical risk factors. Ongoing infections have been suggested to play a role in this process. Periodontal disease is perhaps the most common chronic infection in adults with a wide range of clinical variability and severity. Research in the past decade has shed substantial light on both the initiating infectious agents and host immunological responses in periodontal disease. Up to 46% of the general population harbors the microorganism(s) associated with periodontal disease, although many are able to limit the progression of periodontal disease or even clear the organism(s) if infected. In the last decade, several epidemiological studies have found an association between periodontal infection and atherosclerosis. This review focuses on exploring the molecular consequences of infection by pathogens that exacerbate atherosclerosis, with the focus on infections by the periodontal bacterium Porphyromonas gingivalis as a running example.
Center for Anti-inflammatory Therapeutics, School of Dental Medicine, Boston University, Boston, MA, USA.
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Amar
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Engelke
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D053473:Nod2 Signaling Adaptor Protein / Q000502:physiology; D010510:Periodontal Diseases / Q000276:immunology* / Q000382:microbiology*; D016966:Porphyromonas gingivalis; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology
C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; D051193:Toll-Like Receptors
Porphyromonas gingivalis; atherosclerosis; innate immunity; nucleotide-binding oligomerization domain 2; toll-like receptors