Evaluation of Choroidal Thickness in Amblyopia Using Enhanced Depth Imaging Optical Coherence Tomography.
OBJECTIVE
To evaluate the choroidal thickness (CT) in hyperopic anisometropic amblyopic eyes, fellow non-amblyopic eyes, and age-matched normal eyes, using spectral-domain optical coherence tomography (SD-OCT).


METHODS
In total 53 subjects (17.8 ± 11.0 years, mean ± SD) with hyperopic anisometropic amblyopia (AE) and 53 age-matched controls (17.7 ± 11.0 years) were included in this prospective study. Each subject underwent a dilated eye examination, cycloplegic refraction and axial length (AL) measurement using Nidek AL-Scan optical biometer (Nidek CO, Aichi, Japan). The CT of subfoveal area and at a radius of 1 and 3 mm around the fovea was determined using the enhanced depth imaging program of a SD-OCT (Cirrus HD OCT, Carl-Zeiss Meditec, Dublin, CA). CT, AL and spherical equivalent refraction (SER) of the amblyopic eyes were compared to that of the fellow and control eyes.


RESULTS
The mean subfoveal CT was 305.6 ± 26.0 µm in the amblyopic eyes, 282.6 ± 30.7 µm in the fellow eyes and 280.1 ± 8.8 in the control eyes. The subfoveal choroid in amblyopic eyes was significantly thicker than that of the fellow eyes and control eyes (p <  0.001). There was a significant negative correlation between the subfoveal CT and the AL in amblyopic (r = -0.298, p=0.03) eyes but not in the control and fellow eyes.


CONCLUSIONS
The subfoveal choroid of eyes with hyperopic AE is significantly thicker than that of the fellow eye and the age-matched controls. Hence, CT seems to be effected in AE.
a Department of Ophthalmology , Turgut Özal University, Medical School , Ankara , Turkey and.
Aylin
A
Tenlik
b Department of Ophthalmology , Erciş State Hospital , Van , Turkey.
Emre
E
Güler
a Department of Ophthalmology , Turgut Özal University, Medical School , Ankara , Turkey and.
Ali Ender
AE
Kulak
a Department of Ophthalmology , Turgut Özal University, Medical School , Ankara , Turkey and.
Yüksel
Y
Totan
a Department of Ophthalmology , Turgut Özal University, Medical School , Ankara , Turkey and.
Mehmet Serdar
MS
Dervişoğulları
a Department of Ophthalmology , Turgut Özal University, Medical School , Ankara , Turkey and.
Fatma Betül
FB
Gürağaç
D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000150:complications*; D015858:Anisometropia / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006956:Hyperopia / Q000150:complications*; D008297:Male; D009929:Organ Size; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult
Amblyopia; choroidal thickness; enhanced depth imaging; hyperopic anisometropia; optical coherence tomography