Conventional Cisplatin-Based Combination Chemotherapy Is Effective in the Treatment of Metastatic Spermatocytic Seminoma with Extensive Rhabdomyosarcomatous Transformation.
A 52-year-old man was presented with a huge left testicular mass and palpable cervical lymphadenopathy with retroperitoneal lymph node enlargement on an abdominal computed tomography. A left radical orchiectomy and an ultrasound-guided neck node biopsy were performed. A pathological examination revealed spermatocytic seminoma with extensive rhabdomyosarcomatous transformation, a condition known to be highly resistant to platinum-based chemotherapy. The patient received four cycles of etoposide, ifosfamide and cisplatin (VIP) chemotherapy. A repeat computed tomography revealed a substantial regression consistent with a partial response. Retroperitoneal lymph node dissection was attempted, which revealed rhabdomyosarcoma; however, complete microscopic resection was not achieved. After surgery, the residual abdominal lymph node progressed and salvage paclitaxel, ifosfamide and cisplatin (TIP) chemotherapy was employed, which again achieved a partial response. Here, we present a first case report of a spermatocytic seminoma with extensive rhabdomyosarcomatous transformation and multiple metastatic lymphadenopathies that showed a favorable response to platinum-based systemic chemotherapy.
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Yumun
Y
Jeong
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jaekyung
J
Cheon
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Tae-Oh
TO
Kim
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Doo-Ho
DH
Lim
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Sunpyo
S
Lee
Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Young-Mi
YM
Cho
Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jun Hyuk
JH
Hong
Department of Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.|Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae Lyun
JL
Lee
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005047:Etoposide / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D018239:Seminoma / Q000188:drug therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D005047:Etoposide; D002945:Cisplatin; D007069:Ifosfamide
Drug therapy; Radiotherapy; Seminoma