Room temperature synthesis and antibacterial activity of new sulfonamides containing n,n-diethyl-substituted amido moieties.
Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities. We have synthesized a series of α-tolylsulfonamide, 1-11 and their substituted N,N-diethyl-2-(phenylmethylsulfonamido) alkanamide derivatives, 12-22 in improved and excellent yields in aqueous medium at room temperature through highly economical synthetic routes. The chemical structures of the synthesized compounds 1-22 were confirmed by analytical and spectral data such as IR, (1)H- and (13)C-NMR, and mass spectra. The in vitro antibacterial activity of these compounds along with standard clinical reference, streptomycin, was investigated on two key targeted organisms. It was observed that 1-(benzylsulfonyl)pyrrolidine-2-carboxylic acid, 2 emerged as the most active compound against Staphylococcus aureus at MIC value of 1.8 μg/mL while 4-(3-(diethylamino)-3-oxo-2-(phenylmethylsulfonamido) propyl)phenyl phenylmethanesulfonate, 22 was the most active sulfonamide scaffold on Escherichia coli at MIC value of 12.5 μg/mL.
Department of Chemistry, Covenant University, Canaanland, P.M.B. 1023, Ogun State, Ota, Nigeria.
Olayinka O
OO
Ajani
Department of Chemistry, University of Lagos, Lagos State, Akoka 100001, Nigeria.
Oluwole B
OB
Familoni
New Functional Polymeric Material Group, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.
Feipeng
F
Wu
Department of Chemistry, Covenant University, Canaanland, P.M.B. 1023, Ogun State, Ota, Nigeria.
Johnbull O
JO
Echeme
Test Center of Antimicrobial Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China.
Zheng
Z
Sujiang