Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal.
The complex microstructure of salivary gland pleomorphic adenoma is examined in relation to function. Events related to secretion of macromolecules and absorption, responses to the altered microenvironment and controversies concerning epithelial-mesenchymal transition versus modified myoepithelial differentiation are explored. Their effects on tumor cell phenotypes and arrangements are emphasized. Heterotopic differentiation and attempts at organogenesis are also considered. The approach allows interpreting microstructure independently of histogenetic perceptions, envisaging the tumor cells as a continuum, endorsing luminal structures as the principal components, and defining pleomorphic adenoma as a benign epithelial tumour characterized by variable epithelial-mesenchymal transition, secretion/differentiation and metaplasia.
Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool, Liverpool, UK.
Asterios
A
Triantafyllou
Lester D R
LD
Thompson
Kenneth O
KO
Devaney
Diana
D
Bell
Jennifer L
JL
Hunt
Alessandra
A
Rinaldo
Vincent
V
Vander Poorten
Alfio
A
Ferlito
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D006801:Humans; D012468:Salivary Gland Neoplasms / Q000473:pathology*