Aerobic training suppresses exercise-induced lipid peroxidation and inflammation in overweight/obese adolescent girls.
This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. Thirty-nine adolescent girls (14-19 years old) were classified as nonobese or overweight/obese and then randomly assigned to either the nontrained or trained group (12-week multivariate aerobic training program). Measurements at the beginning of the experiment and at 3 months consisted of body composition, aerobic fitness (VO2peak) and the following blood assays: pre- and postexercise lipid peroxidation (15F2a-isoprostanes [F2-Isop], lipid hydroperoxide [ROOH], oxidized LDL [ox-LDL]) and inflammation (myeloperoxidase [MPO]) markers. In the overweight/ obese group, the training program significantly increased their fat-free mass (FFM) and decreased their percentage of fat mass (%FM) and hip circumference but did not modify their VO2peak. Conversely, in the nontrained overweight/obese group, weight and %FM increased, and VO2peak decreased, during the same period. Training also prevented exercise-induced lipid peroxidation and/or inflammation in overweight/obese girls (F2-Isop, ROOH, ox-LDL, MPO). In addition, in the trained overweight/obese group, exercise-induced changes in ROOH, ox-LDL and F2-Isop were correlated with improvements in anthropometric parameters (waist-to-hip ratio, %FM and FFM). In conclusion aerobic training increased tolerance to exercise-induced oxidative stress in overweight/obese adolescent girls partly as a result of improved body composition.
Laboratory of Movement, Sport, and Health (M2S), University of Rennes 2, Rennes, France.
Hala
H
Youssef
Carole
C
Groussard
Sophie
S
Lemoine-Morel
Joel
J
Pincemail
Christophe
C
Jacob
Elie
E
Moussa
Abdallah
A
Fazah
Josiane
J
Cillard
Jean-Claude
JC
Pineau
Arlette
A
Delamarche
D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D015227:Lipid Peroxidation; D009765:Obesity / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D050177:Overweight / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D009195:Peroxidase