One-pot synthesis of multisubstituted 2-aminoquinolines from annulation of 1-aryl tetrazoles with internal alkynes via double C-H activation and denitrogenation.
An efficient, one-pot synthesis of multisubstituted 2-aminoquinolines from 1-aryl tetrazoles and internal alkynes has been developed. The reaction involves cyclization of 1-aryl tetrazoles with internal alkynes via rhodium(III)-catalyzed double C-H activation and copper(II)-mediated denitrogenation.
Department of Chemistry, Tsinghua University , Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Beijing 100084, China.
Lei
L
Zhang
Liyao
L
Zheng
Biao
B
Guo
Ruimao
R
Hua
D000480:Alkynes / Q000737:chemistry*; D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D006860:Hydrogen Bonding; D010084:Oxidation-Reduction; D013777:Tetrazoles / Q000737:chemistry*
D000480:Alkynes; D000634:Aminoquinolines; D013777:Tetrazoles; D003300:Copper