Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts.
A new efficient and highly enantioselective direct asymmetric hydrogenation of α-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral α-hydroxy acids on a large scale.
Zhejiang Jiuzhou Pharmaceutical Co., Ltd., 99 Waisha Road, Jiaojiang District, Taizhou City, Zhejiang Province 318000, P. R. China. dqche@zbjz.cn.
Pu-Cha
PC
Yan
Jian-Hua
JH
Xie
Xiang-Dong
XD
Zhang
Kang
K
Chen
Yuan-Qiang
YQ
Li
Qi-Lin
QL
Zhou
Da-Qing
DQ
Che
D002384:Catalysis; D006038:Glyoxylates / Q000737:chemistry; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D007651:Keto Acids / Q000737:chemistry*; D008333:Mandelic Acids / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D006038:Glyoxylates; D007651:Keto Acids; D008333:Mandelic Acids; D013141:Spiro Compounds; C012482:phenylglyoxylic acid; D007495:Iridium