Blood plasma lipidomic signature of epicardial fat in healthy obese women.
OBJECTIVE
A lipidomic approach was employed in a clinically well-defined cohort of healthy obese women to explore blood lipidome phenotype ascribed to body fat deposition, with emphasis on epicardial adipose tissue (EAT).


METHODS
The present investigation delivered a lipidomics signature of epicardial adiposity under healthy clinical conditions using a cohort of 40 obese females (age: 25-45 years, BMI: 28-40 kg/m(2) ) not showing any metabolic disease traits. Lipidomics analysis of blood plasma was employed in combination with in vivo quantitation of mediastinal fat depots by computerized tomography.


RESULTS
All cardiac fat depots correlated to indicators of hepatic dysfunctions (ALAT and ASAT), which describe physiological connections between hepatic and cardiac steatosis. Plasma lipidomics encompassed overall levels of lipid classes, fatty acid profiles, and individual lipid species. EAT and visceral fat associated with diacylglycerols (DAG), triglycerides, and distinct phospholipid and sphingolipid species. A pattern of DAG and phosphoglycerols was specific to EAT.


CONCLUSIONS
Human blood plasma lipidomics appears to be a promising clinical and potentially diagnostic readout for patient stratification and monitoring. Association of blood lipidomics signature to regio-specific mediastinal and visceral adiposity under healthy clinical conditions may help provide more biological insights into obese patient stratification for cardiovascular disease risks.
Nestlé Institute of Health Sciences SA, Lausanne, Switzerland.
Max
M
Scherer
Ivan
I
Montoliu
Salah D
SD
Qanadli
Sebastiano
S
Collino
Serge
S
Rezzi
Martin
M
Kussmann
Vittorio
V
Giusti
François-Pierre J
FP
Martin
D000273:Adipose Tissue / Q000000981:diagnostic imaging / Q000378:metabolism*; D050154:Adiposity; D000328:Adult; D015331:Cohort Studies; D004075:Diglycerides / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006262:Health; D006801:Humans; D008055:Lipids / Q000097:blood*; D055432:Metabolomics; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D010496:Pericardium / Q000000981:diagnostic imaging / Q000378:metabolism*; D010743:Phospholipids / Q000097:blood; D013107:Sphingolipids / Q000097:blood; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D004075:Diglycerides; D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D013107:Sphingolipids; D014280:Triglycerides