Insulin-like growth factor receptor 1 (IGF1R) expression and survival in non-small cell lung cancer patients: a meta-analysis.
The insulin-like growth factor receptor-1 (IGF1R) plays an important role in cancer progression. Previous studies have been controversial with respect to the associations between IGF1R expression and non small cell lung cancer (NSCLC) prognosis. Thus, we performed a meta-analysis to investigate the prognostic value of IGF1R expression in NSCLC patients and the relationship between the expression of IGF1R and clinical characteristics. Two independent reviewers searched PubMed, Embase, Ovid Medline and CNKI to identify eligible studies. Overall survival (OS), disease free survival (DFS) and clinicopathological characteristics were collected from included studies. Pooled hazard ratios (HRs) or odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to estimate the effect. 17 studies comprising 3,294 patients were included in this meta-analysis. The results showed IGF1R positive expression was associated with an unfavorable DFS in NSCLC patients on univariate analysis (HR = 1.26, 95% CI: 1.09-1.46, P = 0.002) and multivariate analysis (HR = 1.49, 95% CI: 1.01-2.20, p = 0.045), but the relationship between IGF1R expression and OS have no significant difference on univariate analysis (HR = 0.91, 95% CI: 0.82-1.01, P = 0.157) and multivariate analysis (HR = 0.79, 95% CI: 0.45-1.41, P = 0.427). Ever smoking and smaller tumor size (T1 or T2) were associated with IGF1R positive expression: pooled OR 1.45 (1.13-1.85) and pooled OR 0.61 (0.60-0.95). Our results suggested IGF1R positive expression as an unfavorable factor for DFS in NSCLC patients, and IGF1R expression was associated with smoking status and tumor size.
Department of Respiratory Medicine, West China Hospital, Sichuan University Chengdu 610041, P. R. China.
Shuang
S
Zhao
Department of Respiratory Medicine, West China Hospital, Sichuan University Chengdu 610041, P. R. China.
Zhixin
Z
Qiu
Department of Radiation Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Chengdu 610041, China.
Jinlan
J
He
Department of Respiratory Medicine, West China Hospital, Sichuan University Chengdu 610041, P. R. China.
Lei
L
Li
Department of Respiratory Medicine, West China Hospital, Sichuan University Chengdu 610041, P. R. China.
Weimin
W
Li
D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016014:Linear Models; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D015999:Multivariate Analysis; D016017:Odds Ratio; D017526:Receptor, IGF Type 1; D017451:Receptors, Somatomedin / Q000032:analysis*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D013997:Time Factors; D047368:Tumor Burden
D014408:Biomarkers, Tumor; C000597236:IGF1R protein, human; D017451:Receptors, Somatomedin; D017526:Receptor, IGF Type 1
Insulin-like growth factor receptor-1 (IGF1R); disease free survival (DFS); meta-analysis; non-small cell lung cancer (NSCLC); overall survival (OS); prognosis