Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats.
BACKGROUND
The kidney is a target organ for injuries caused by advanced glycation end products (AGEs) in obesity. The receptor of AGEs (RAGE) is proinflammatory and appears to have a role in the pathogenesis of renal disease due to obesity.


OBJECTIVE
The aim was to verify the effect of obesity on renal damage and the effect of lycopene on these complicationsDesign and Methods:Male Wistar rats were randomly assigned to receive a control diet (C, n=7) or a high-fat diet plus sucrose (HD+S, n=14) for 6 weeks. After this period, the HD+S animals were randomized into two groups: HD+S (n=7) and HD+S supplemented with lycopene (HD+S+L, n=7). The animals received maize oil (C and HD+S) or lycopene (HD+S+L) for a 6-week period.


RESULTS
The HD+S and HD+S+L animals demonstrated insulin resistance (OGTT glucose after 150 min; C: 117.6±3.9<HD+S: 138.1±5.1=HD+S+L: 137.8±5.2 mg dl(-1); P=0.01); however, no changes were seen in fasting glucose, plasma lipids, blood pressure or renal function. Renal concentrations of RAGE and TNF-α increased in the HD+S group and lycopene supplementation restored these to control group values (RAGE: C: 3.1±0.3=DH+S+L: 3.1±0.3<DH+S: 3.6±0.4 μg g(-1); P=0.014; TNF-α: C: 227.8±2.7=DH+S+L: 227.4±2.2<DH+S: 238.7±3.0 pg/ml; P=0.014).


CONCLUSIONS
Lycopene may be beneficial in the prevention and treatment of oxidative stress and inflammation in the kidney due to obesity.
1] Pathology Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil [2] Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
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Pierine
Pathology Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil.
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ME
Navarro
1] Pathology Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil [2] Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
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Minatel
1] Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA [2] Internal Medicine Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil.
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Luvizotto
1] Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA [2] Internal Medicine Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil.
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Nascimento
Internal Medicine Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil.
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Ferreira
1] Jean Mayer Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA [2] Food and Nutrition Major, Division of Food Bioscience, College of Biomedical and Health Sciences, Konkuk University, Glocal Campus, Seoul, South Korea.
K-J
KJ
Yeum
Pathology Department, Botucatu Medical School-São Paulo State University-UNESP, Botucatu, Brazil.
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Corrêa