A magnetic induction heating system with multi-cascaded coils and adjustable magnetic circuit for hyperthermia.
Based on the characteristics of cancer cells that cannot survive in an environment with temperature over 42 °C, a magnetic induction heating system for cancer treatment is developed in this work. First, the methods and analyses for designing the multi-cascaded coils magnetic induction hyperthermia system are proposed, such as internal impedance measurement of power generator, impedance matching of coils, and analysis of the system. Besides, characteristics of the system are simulated by a full-wave package for engineering optimization. Furthermore, by considering the safety factor of patients, a two-sectional needle is designed for hyperthermia. Finally, this system is employed to test the liver of swine in ex-vivo experiments, and through Hematoxylin and Eosin (H&E) stain and NADPH oxidase activity assay, the feasibility of this system is verified.
a Institute of Communication Engineering, Tatung University , Taipei , Taiwan and.
Chi-Fang
CF
Huang
a Institute of Communication Engineering, Tatung University , Taipei , Taiwan and.
Hsuan-Yi
HY
Chao
a Institute of Communication Engineering, Tatung University , Taipei , Taiwan and.
Hsun-Hao
HH
Chang
b Department of Internal Medicine , National Cheng Kung University , Tainan , Taiwan.
Xi-Zhang
XZ
Lin
D000818:Animals; D004560:Electricity; D004867:Equipment Design; D006361:Heating / Q000295:instrumentation*; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008099:Liver; D060328:Magnetic Phenomena; D013552:Swine
Coils; H&E stain; NADPH; eddy current; hyperthermia; induction heating; magnetic circuit