Virtual Systems Pharmacology (ViSP) software for simulation from mechanistic systems-level models.
Multiple software programs are available for designing and running large scale system-level pharmacology models used in the drug development process. Depending on the problem, scientists may be forced to use several modeling tools that could increase model development time, IT costs and so on. Therefore, it is desirable to have a single platform that allows setting up and running large-scale simulations for the models that have been developed with different modeling tools. We developed a workflow and a software platform in which a model file is compiled into a self-contained executable that is no longer dependent on the software that was used to create the model. At the same time the full model specifics is preserved by presenting all model parameters as input parameters for the executable. This platform was implemented as a model agnostic, therapeutic area agnostic and web-based application with a database back-end that can be used to configure, manage and execute large-scale simulations for multiple models by multiple users. The user interface is designed to be easily configurable to reflect the specifics of the model and the user's particular needs and the back-end database has been implemented to store and manage all aspects of the systems, such as Models, Virtual Patients, User Interface Settings, and Results. The platform can be adapted and deployed on an existing cluster or cloud computing environment. Its use was demonstrated with a metabolic disease systems pharmacology model that simulates the effects of two antidiabetic drugs, metformin and fasiglifam, in type 2 diabetes mellitus patients.
Exploratory Clinical and Translational Research, Bristol-Myers Squibb Princeton, NJ, USA.
Sergey
S
Ermakov
Forster Solutions, LLC Wilmington, DE, USA.
Peter
P
Forster
Research IT and Automation, Bristol-Myers Squibb Princeton, NJ, USA.
Jyotsna
J
Pagidala
Research IT and Automation, Bristol-Myers Squibb Princeton, NJ, USA.
Marko
M
Miladinov
Research IT and Automation, Bristol-Myers Squibb Princeton, NJ, USA.
Albert
A
Wang
Rosa & Co. LLC San Carlos, CA, USA.
Rebecca
R
Baillie
Rosa & Co. LLC San Carlos, CA, USA.
Derek
D
Bartlett
Rosa & Co. LLC San Carlos, CA, USA.
Mike
M
Reed
Exploratory Clinical and Translational Research, Bristol-Myers Squibb Princeton, NJ, USA.
Tarek A
TA
Leil
metabolic diseases model; model development software; quantitative systems pharmacology; simulation experiment; system-level mechanistic models; virtual patient