A polymorphism (-455G>A) in the β-fibrinogen gene is associated with an increased risk of cerebral infarction in the Chinese population: A meta-analysis.
BACKGROUND
Previous studies have investigated the association between a polymorphism (-455 G>A) in the β-fibrinogen gene and the risk of cerebral infarction. However, these results are controversial. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the β-fibrinogen genetic polymorphism (-455 G>A) to the risk of cerebral infarction.


METHODS
We identified literature published before July 2013 by searching PubMed, EMBASE, ISI Web of Science, the Chinese National Knowledge Infrastructure database (CNKI) and the Wanfang database in China and by reviewing the references of retrieved articles. We included studies that reported odds ratio (OR) with 95% confidence interval (CI) for the association between the β-fibrinogen genetic polymorphism and cerebral infarction risk. Publication bias was tested by a funnel plot, and the OR of all studies were combined dependent on the results of the heterogeneity tests among the individual studies. The software Review Manager (Version 5.2) was used for meta-analysis.


RESULTS
Twenty independent case-control studies containing 9477 subjects were included. Our results showed that the -455 G>A polymorphism in the β-fibrinogen gene was associated with the increased risk of cerebral infarction [(AA+GA) vs. GG, OR=1.17, 95%CI: 1.04-1.31, p=0.008; A vs. G, OR=1.12, 95%CI: 1.01-1.23, p=0.03] in the Chinese population by a meta-analysis. However, we did not find this association in the Caucasian population [(AA+GA) vs. GG, OR=0.99, 95%CI: 0.87-1.11, p=0.84; A vs. G, OR=0.97, 95%CI: 0.84-1.13, p=0.73, respectively].


CONCLUSIONS
The results of our meta-analysis indicate that the -455 G>A polymorphism in the β-fibrinogen gene is a susceptibility marker of ischemic cerebral infarction in the Chinese population.
Department of Neurology, Second Affiliated Hospital and XinQiao Hospital,Third Military Medical University,Chongqing 400037,China zhaozhubo_2013@163.com.
Sai-Yu
SY
Cheng
Department of Neurobiology, College of Basic Medical Sciences, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, China.
Yan-Dong
YD
Zhao
Department of Physiology, Zunyi Medical College, China.
Jun-Wei
JW
Zeng
Department of Neurology, Second Affiliated Hospital and XinQiao Hospital,Third Military Medical University,Chongqing 400037,China.
Xiao-Yan
XY
Chen
Department of Neurology, Second Affiliated Hospital and XinQiao Hospital,Third Military Medical University,Chongqing 400037,China.
Ruo-Dan
RD
Wang
D044466:Asian People / Q000235:genetics*; D002544:Cerebral Infarction / Q000235:genetics*; D002681:China; D005340:Fibrinogen / Q000235:genetics*; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
D005340:Fibrinogen
Meta-analysis; ischemic stroke; β-fibrinogen