Expression of Endoglin (CD-105) and Microvessel Density in Oral Dysplasia and Squamous Cell Carcinoma.
OBJECTIVE
To assess the expression of Endoglin (CD-105) and Microvessel Density in clinically normal oral mucosa of non-tobacco and tobacco habituated patients & also histopathologically confirmed cases of oral squamous cell carcinoma (OSCC) patients.


METHODS
Twenty cases of clinically normal oral mucosa with tobacco habituation in the form of chewing or smoking, 20 histopathologically confirmed cases of OSCC and twelve normal healthy oral mucosal cases without tobacco habituation in any form, served as control group, were immunohistochemically analysed for expression of Endoglin (CD-105). Chi-square test is used to determine statistical analysis and significance.


CONCLUSIONS
The finding of 65% of Endoglin CD - 105 positivity and microvessel density (MVD) in the mucosal specimens of tobacco users may be attributed as neoangiogenesis or angiogenic squamous dysplasia like phenomenon occurring as important pathological biomarker preceding oral cancer development, and may therefore be useful as a predictive marker of malignancy.
Professor and Head of the Department, Department of Oral Pathology & Microbiology, H.K.E.'s S. Nijalingappa Institute of Dental sciences & Research Center , Gulbarga, India .
Maharudrappa
M
Basnaker
Post Graduate Student, Department of Oral Pathology & Microbiology, H.K.E.'s S. Nijalingappa Institute of Dental sciences & Research Center , Gulbarga, India .
Shashikanth
S
Sr
Professor, Department of Oral Pathology & Microbiology, H.K.E.'s S. Nijalingappa Institute of Dental sciences & Research Center , Gulbarga, India .
Satish
S
Bnvs
Angiogenisis; Endoglin CD 105; Microvessel density; Oral dysplasia; Oral squamous cell carcinoma; Tobacco chewers