Multigenerational chromatin marks: no enzymes need apply.
Epigenetic memory stably maintains and transmits information during genome replication. Recently in Science, Gaydos et al. (2014) show that repressive chromatin marks exhibit transgenerational stability in the absence of chromatin-modifying enzymes in Caenorhabditis elegans, in contrast to work in flies suggesting that such proteins mediate stable inheritance of epigenetic modifications.
Biology Department, Emory University, Atlanta, GA 30322, USA. Electronic address: bkelly@emory.edu.
William G
WG
Kelly
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology* / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000378:metabolism*; D056466:Histone Demethylases / Q000378:metabolism*; D008297:Male; D063151:Polycomb Repressive Complex 2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D014960:X Chromosome / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D056466:Histone Demethylases; D063151:Polycomb Repressive Complex 2