Retracted: Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian population.
OBJECTIVE
The association of the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism with type-2 diabetic nephropathy (T2DN) susceptibility and the risk of type-2 diabetes mellitus (T2DM) developing into T2DN in Caucasian populations is still controversial. A meta-analysis was performed to evaluate the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations.


METHODS
A predefined literature search and selection of eligible relevant studies were performed to collect data from electronic databases.


RESULTS
Sixteen articles were identified for the analysis of the association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in Caucasian populations. ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. Sensitivity analysis according to sample size of case (<100 vs. ≥100) was also performed, and the results were similar to the non-sensitivity analysis.


CONCLUSIONS
ACE I/D gene polymorphism was not associated with T2DN susceptibility and the risk of patients with T2DM developing T2DN in Caucasian populations. However, more studies should be performed in the future.
Department of Nephrology, Dong Guan Municipal People's Hospital, Dongguan, China.
Guohui
G
Liu
Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China.
Tian-Biao
TB
Zhou
Department of Nephrology, the Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510655, China zongpeijiang@yeah.net.
Zongpei
Z
Jiang
Department of Nephrology, Dong Guan Municipal People's Hospital, Dongguan, China.
Dongwen
D
Zheng
Type-2 diabetic nephropathy (T2DN); angiotensin-converting enzyme (ACE); insertion/deletion (I/D) gene polymorphism; meta-analysis; type-2 diabetes mellitus (T2DM)