Pathogenicity of border disease virus FNK2012-1 strain isolated from a pig in the natural host, sheep.
A first isolation of border disease virus (BDV) in Japan was from a pig on a farm without keeping any ruminants. Our previous study showed that this BDV, termed the FNK2012-1 strain, replicated inefficiently in swine-derived cells compared with those of ruminant origin. Pigs inoculated with this virus showed neither clinical symptoms nor viremia. In this study, we evaluated the pathogenicity of the FNK2012-1 strain in sheep, its natural host. The inoculated sheep showed clinical symptoms and transient viremia. Seroconversion was observed in the inoculated sheep. These results suggest that the FNK2012-1 strain was introduced from sheep and has not yet adapted to swine. Therefore, surveillance of border disease in Japan is necessary among both the swine and ruminant populations.
Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
Tomokazu
T
Tamura
Junki
J
Mine
Shiho
S
Torii
Yuri
Y
Fujimoto
Masatoshi
M
Okamatsu
Yoshihiro
Y
Sakoda
D000818:Animals; D001831:Body Temperature; D001882:Border Disease / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D018083:Border disease virus / Q000302:isolation & purification / Q000472:pathogenicity*; D058507:Host Specificity; D007564:Japan / Q000453:epidemiology; D012756:Sheep; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000821:virology*