[Reaction of bone tissue elements on synthetic bioresorbable materials based on lactic and glycolic acids].
The aim of the study was to evaluate the adverse effects of synthetic polymeric bioresorbable materials based on lactic and glycolic acids on the bone tissue. The study was carried-out on 40 Wister-line rats. Four types of bioresorbable polymeric materials were implanted: PolyLactide Glycolide Acid (PLGA), Poly-L-Lactide Acid (PLLA); Poly-96L/4D-Lactide Acid (96/4 PLDLA); Poly-70L/30D-Lactide Acid (70/30 PLDLA). The results showed connective tissue formation (fibrointegration) bordering bone adjacent to implanted materials. This proved the materials to cause pathogenic influence on the bone which mechanisms are described in the article.
A A
AA
Kulakov
A S
AS
Grigor'ian
D020341:Absorbable Implants / Q000009:adverse effects*; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D006016:Glycolates / Q000009:adverse effects*; D019344:Lactic Acid / Q000009:adverse effects*; D008297:Male; D011091:Polyesters / Q000009:adverse effects*; D011100:Polyglycolic Acid / Q000009:adverse effects*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D051381:Rats; D017208:Rats, Wistar
D006016:Glycolates; D011091:Polyesters; C031149:glycolic acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide)