Vertebral infection with Candida albicans failing caspofungin and fluconazole combination therapy but successfully treated with high dose liposomal amphotericin B and flucytosine.
A patient with Candida spondylitis failed two weeks of fluconazole combined with caspofungin, and the infection relapsed despite six weeks of liposomal amphotericin B followed by two months of fluconazole. Six months therapy with high dose liposomal amphotericin B combined with flucytosine effectively cured the patient.
Department of Infectious Diseases, Aarhus University Hospital Skejby, 100 Brendstrupgaardsvej, 8200 Aarhus N, Denmark.
Line
L
Storm
Department of Infectious Diseases, Aarhus University Hospital Skejby, 100 Brendstrupgaardsvej, 8200 Aarhus N, Denmark.
Karen R
KR
Lausch
Unit of Mycology, Department of Microbiology and Infection Control, Statens Serum Institut, 5 Artillerivej, 2300 Copenhagen S, Denmark.
Maiken C
MC
Arendrup
Department of Infectious Diseases, Aarhus University Hospital Skejby, 100 Brendstrupgaardsvej, 8200 Aarhus N, Denmark.
Klaus L
KL
Mortensen
Department of Infectious Diseases, Aarhus University Hospital Skejby, 100 Brendstrupgaardsvej, 8200 Aarhus N, Denmark.
Eskild
E
Petersen
Amphotericin B; Candida albicans; Fluconazole; Flucytosine; Spondylitis