Association of selenoprotein S gene polymorphism with ischemic stroke in a Chinese case-control study.
Previous studies showed that selenoprotein S (SELS) was associated with a range of inflammatory markers, and its gene expression was influenced by a polymorphism in the promoter region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of SELS genetic variants in the ischemic stroke risk in a Chinese population. We conducted a case-control study with 239 ischemic stroke patients and 240 controls. Two single-nucleotide polymorphisms (SNPs) in SELS genes were analyzed for association with the risk of ischemic stroke in the Chinese Han population. No evidence of ischemic stroke association was observed with the SNP rs34713741. Interestingly, the strongest evidence showed that SELS SNP rs4965814 was associated with ischemic stroke (P < 0.05). We found a significant association with increased ischemic stroke risk in women carrying the CC genotype of rs4965814 [hazard ratio: 2.43(1.03-5.75)]; a similar trend was also found in men carrying the TC genotype of rs4965814 [hazard ratio: 1.81(1.06-3.08)]. SNP rs4965814 of SELS may affect the susceptibility to ischemic stroke. Understanding the inflammatory mechanisms of ischemic stroke may give new therapeutic targets to pharmacologists.
aDepartment of Preventive Medicine, Mudanjiang Medical University, Mudanjiang, Heilongjiang bShenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong cHongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang, PR China.
Xiao-Xia
XX
Li
Hong-Jun
HJ
Guan
Jian-Ping
JP
Liu
Yu-Peng
YP
Guo
Yong
Y
Yang
Ying-Ying
YY
Niu
Li-Yan
LY
Yao
Yin-Dong
YD
Yang
Hong-Yu
HY
Yue
Li-Li
LL
Meng
Xin-Yu
XY
Cui
Xiao-Wei
XW
Yang
Jin-Xiao
JX
Gao
D044466:Asian People / Q000235:genetics*; D002545:Brain Ischemia / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D051140:Selenoproteins / Q000235:genetics*; D020521:Stroke / Q000235:genetics*
D008565:Membrane Proteins; C487710:SELENOS protein, human; D051140:Selenoproteins