Experimental study of the efficiency of oxidized dextran for prevention of influenza A/H5N1.
Oxidized dextran is suggested for prevention of infection induced by influenza A/H5N1 viruses, methods of its use and doses are determined. Two intravenous injections of dextran 3 and 1 days before experimental infection of outbred mice by influenza A/H5N1 A/goose/Krasnoozerskoye/627/05 virus resulted in a high preventive dose-dependent effect: the mean lifespan was 25% prolonged, the mortality decreased 3-fold.
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
V A
VA
Shkurupy
O V
OV
Potapova
T V
TV
Sharkova
A V
AV
Troitskii
E P
EP
Gulyaeva
T N
TN
Bystrova
A M
AM
Shestopalov
D000818:Animals; D021461:Animals, Outbred Strains; D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003911:Dextrans / Q000494:pharmacology / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000517:prevention & control* / Q000821:virology; D010084:Oxidation-Reduction
D000998:Antiviral Agents; D003911:Dextrans