Orbital hemorrhage after intravitreal injection.
OBJECTIVE
To describe a case of orbital hemorrhage after the administration of intravitreal ranibizumab.


METHODS
Retrospective chart review of one case.


RESULTS
A 73-year-old woman with a history of atrial fibrillation on coumadin anticoagulation (international normalized ratio = 3.4) presented with decreased vision and metamorphopsia in her right eye for 2 weeks duration. Examination was consistent with a diagnosis of neovascular age-related macular degeneration in the right eye. After one injection of intravitreal ranibizumab, she developed a bullous subconjunctival hemorrhage that extended into an orbital hemorrhage.


CONCLUSIONS
Intravitreal injection may result in orbital hemorrhage, particularly in the anticoagulated patient.
*Retina Service †Oculoplastics and Orbital Surgery Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania.
Gary
G
Shienbaum
Richard S
RS
Kaiser
Scott M
SM
Goldstein