Absorbability, mechanism and structure-property relationship of three phenolic acids from the flowers of Trollius chinensis.
The absorption properties, mechanism of action, and structure-property relationship of three phenolic acids isolated from the flowers of Trollius chinensis Bunge, namely, proglobeflowery acid (PA), globeflowery acid (GA) and trolloside (TS), were investigated using the human Caco-2 cell monolayer model. The results showed that these three phenolic acids were transported across the Caco-2 cell monolayer in a time and concentration dependent manner at the Papp level of 10-5 cm/s, and their extent of absorption correlated with their polarity and molecular weight. In conclusion, all three of these compounds were easily absorbed through passive diffusion, which implied their high bioavailability and significant contribution to the effectiveness of T. chinensis.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. wuxiuwen0725@126.com.
Xiu-Wen
XW
Wu
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. wangrufeng@tsinghua.org.cn.
Ru-Feng
RF
Wang
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. lily199109231@163.com.
Li-Jia
LJ
Liu
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. gngn2010@163.com.
Li-Na
LN
Guo
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China. 15201391380@163.com.
Can
C
Zhao
D018938:Caco-2 Cells; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D010226:Parabens / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics / Q000494:pharmacology; D029626:Ranunculaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship
D062385:Hydroxybenzoates; D010226:Parabens; C080719:proglobeflowery acid; C017616:phenolic acid