Is Cytoplasmic PTEN a Specific Target for Neuronal Survival?
The differential sensitivity of neurons to phosphatase and tensin homolog's (PTEN) lipid and protein phosphatase actions pose difficulties in defining the exact neuronal phenotype generated by targeting PTEN in neuronal injury. PTEN's biology beyond its phosphatase functions are also emerging. Considering spatial dynamics of PTEN a decisive factor for its mode of action we propose selective targeting of its cytoplasmic fraction a better therapeutic approach in neuronal injury.
Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2E3.26 Walter C Mackenzie, Health Sciences Center, Edmonton, AB, T6G 2B7, Canada.|Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2E3.26 Walter C Mackenzie, Health Sciences Center, Edmonton, AB, T6G 2B7, Canada.
Anand
A
Krishnan
Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2E3.26 Walter C Mackenzie, Health Sciences Center, Edmonton, AB, T6G 2B7, Canada. zochodne@ualberta.ca.|Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2E3.26 Walter C Mackenzie, Health Sciences Center, Edmonton, AB, T6G 2B7, Canada. zochodne@ualberta.ca.
Douglas W
DW
Zochodne
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000378:metabolism; D050356:Lipid Metabolism / Q000502:physiology; D008840:Microfilament Proteins / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D000070876:Tensins
D008840:Microfilament Proteins; D000070876:Tensins; D051059:PTEN Phosphohydrolase
Akt; Apoptosis; Neuron; PTEN