Fatty acid compositions of triglycerides and free fatty acids in sebum depend on amount of triglycerides, and do not differ in presence or absence of acne vulgaris.
To clarify the influence of the fatty acid composition of sebum in acne vulgaris, we investigated the amounts and fatty acid compositions of triglycerides (TG) and free fatty acids (FFA), and the amounts of cutaneous superficial Propionibacterium acnes in acne patients and healthy subjects. The foreheads of 18 female patients, 10 male patients, 10 healthy females and 10 healthy males were studied in a Japanese population. There were significant differences in the amounts of sebum, TG and cutaneous superficial P. acnes, as well as the fatty acid compositions of TG and FFA between acne patients and healthy subjects in females. Their fatty acid compositions were correlated with the amount of TG with or without acne. It was clarified that the fatty acid compositions of TG and FFA depended on the amount of TG, and there were no differences in the fatty acid composition in the presence and absence of acne.
Research Laboratories, Nippon Menard Cosmetic, Nagoya, Japan; Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Narifumi
N
Akaza
Hirohiko
H
Akamatsu
Shigeki
S
Numata
Miyuki
M
Matsusue
Yasuo
Y
Mashima
Masaaki
M
Miyawaki
Shunji
S
Yamada
Akiko
A
Yagami
Satoru
S
Nakata
Kayoko
K
Matsunaga
D000152:Acne Vulgaris / Q000378:metabolism* / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D011425:Propionibacterium acnes / Q000302:isolation & purification; D012629:Sebum / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*; D055815:Young Adult
D005227:Fatty Acids; D014280:Triglycerides
Propionibacterium acnes; acne vulgaris; free fatty acid; sebum; triglyceride