Broad scope hydrofunctionalization of styrene derivatives using iron-catalyzed hydromagnesiation.
The highly regioselective iron-catalyzed formal hydrofunctionalization of styrene derivatives with a diverse range of electrophiles has been developed using a single, operationally simple hydromagnesiation procedure and only commercially available, bench-stable reagents. Using just 0.5 mol % FeCl2·4H2O and N,N,N',N'-tetramethylethylenediamine, hydromagnesiation and electrophilic trapping have been used to form new carbon-carbon bonds (13 examples) and carbon-heteroatom bonds (5 examples) including the products of formal cross-coupling reactions, hydroboration, hydroamination, hydrosilylation, and hydrofluorination.
School of Chemistry, University of Edinburgh , Joseph Black Building, David Brewster Road, Edinburgh EH9 3FJ, United Kingdom.
Alison S
AS
Jones
James F
JF
Paliga
Mark D
MD
Greenhalgh
Jacob M
JM
Quibell
Alan
A
Steven
Stephen P
SP
Thomas