Co-existence of extramammary Paget's disease and Bowen's disease of vulva.
Extramammary Paget's disease and Bowen's disease are histologically similar and immunohistochemistry is often required to make the diagnosis. We present a case of vulval Paget's disease with Bowen's disease in an elderly female. Strong positivity for cytokeratin 7, anti CAM 5.2, carcinoembryonic antigen (CEA) and periodic acid-Schiff (PAS) stain in clitoral, left labial and interface regions of the vulvectomy specimen confirmed the diagnosis of Paget's disease (PD) while positive staining for p63 in the right labial and interface regions helped in establishing the diagnosis of concurrent Bowen's disease (BD).
Departments of Dermatology, Venereology and Leprosy, Muzaffarnagar Medical College and Hospital, Uttar Pradesh, India.
Tarang
T
Goyal
Anupam
A
Varshney
Ranjan
R
Solanki
D015415:Biomarkers / Q000032:analysis; D001913:Bowen's Disease / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D053552:Keratin-7 / Q000032:analysis; D007633:Keratins / Q000032:analysis; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010145:Paget Disease, Extramammary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
D015415:Biomarkers; C400901:CAM 5.2 antigen; C081876:CKAP4 protein, human; D002272:Carcinoembryonic Antigen; D053552:Keratin-7; D008565:Membrane Proteins; D007633:Keratins