Gemcitabine associated retinopathy and nephropathy.
OBJECTIVE
To report a case of presumed gemcitabine-induced retinopathy and nephropathy.


METHODS
Case Report. Retrospective chart review.


RESULTS
A 64-year-old woman with a recent diagnosis of metastatic cholangiocarcinoma presented with progressive visual loss and renal failure shortly after the initiation of a chemotherapy regimen which included gemcitabine. Clinical examination and fluorescein angiography showed findings of severe retinal ischemia.


CONCLUSIONS
Although gemcitabine chemotherapy has been reported to cause a Purtscher-like retinopathy, we propose in our patient a gemcitabine-induced vasculopathy that lead to significant retinal and renal ischemia.
*Department of Ophthalmology, Mount Sinai School of Medicine, New York, New York; †Department of Ophthalmology, NYU School of Medicine, New York, New York; and ‡Vitreous Retina Macula Consultants of New York, New York, New York.
Alan T
AT
Sheyman
Kenneth J
KJ
Wald
Patricia J
PJ
Pahk
K Bailey
KB
Freund
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D008875:Middle Aged; D012164:Retinal Diseases / Q000139:chemically induced*; D012189:Retrospective Studies; D014786:Vision Disorders / Q000139:chemically induced*; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine