Surgical complications related to transplanted pancreas after simultaneous pancreas and kidney transplantation.
OBJECTIVE
Simultaneous pancreas and kidney transplantation (SPTKx) is characterized by the high rate and variability of postoperative complications, which could be a limitation of this treatment. The aim of this study was to evaluate prevalence, types, and severity of postoperative complications due to pancreas graft among the simultaneous pancreas and kidney recipients.


METHODS
Postoperative complications related to transplanted pancreas among 112 SPTKx recipients were analyzed. The cumulative survival rates for pancreas graft function and cumulative freedom from complication on day 60 after transplantation were assessed. Severity of complications was classified according to a modified Clavien-Dindo scale.


RESULTS
The 12-month cumulative survival rate for pancreatic graft was 0.74. Cumulative freedom from complication on the 60th day after transplantation was 0.57. The rates for II, IIIA, IIIB, IVA, and IVB severity grades were 10,6%, 4,5%, 19,7%, 44%, and 21,2%, respectively. The most severe (IVB) transplanted pancreas complications were due to graft inflammation, infection, pancreatic abscess, and local or diffuse necrosis. The most frequent reason for graft pancreatectomy was vascular thrombosis 35.9% (14/39). The mortality rate after graft pancreatectomy was significantly lower for vascular thrombosis than for infection (0/14 vs 11/25; P < .05).


CONCLUSIONS
Reducing vascular thrombosis could preserve graft function rate. Preventing graft inflammation and infection would reduce mortality.
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland. Electronic address: tadeusz.grochowiecki@wum.edu.pl.
T
T
Grochowiecki
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
Z
Z
Gałązka
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
K
K
Madej
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
S
S
Frunze
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
S
S
Nazarewski
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
T
T
Jakimowicz
Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Poland.
L
L
Pączek
Department of Transplantation Medicine and Nephrology, Medical University of Warsaw, Poland.
M
M
Durlik
Department of General, Vascular and Transplant Surgery, Medical University of Warsaw, Poland.
J
J
Szmidt
D000038:Abscess / Q000453:epidemiology*; D000328:Adult; D005260:Female; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000098:blood supply; D016035:Pancreas Transplantation / Q000009:adverse effects*; D010180:Pancreatectomy; D010195:Pancreatitis / Q000453:epidemiology*; D011183:Postoperative Complications / Q000453:epidemiology*; D013927:Thrombosis / Q000453:epidemiology* / Q000601:surgery; D055815:Young Adult