Evolution of moonlighting proteins: insight from yeasts.
The present article addresses the possibilities offered by yeasts to study the problem of the evolution of moonlighting proteins. It focuses on data available on hexokinase from Saccharomyces cerevisiae that moonlights in catabolite repression and on galactokinase from Kluyveromyces lactis that moonlights controlling the induction of the GAL genes. Possible experimental approaches to studying the evolution of moonlighting hexose kinases are suggested.
*Department of Metabolism and Cell Signalling. Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid E-28029, Spain.
Carlos
C
Gancedo
*Department of Metabolism and Cell Signalling. Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid E-28029, Spain.
Carmen-Lisset
CL
Flores
*Department of Metabolism and Cell Signalling. Instituto de Investigaciones Biomédicas "Alberto Sols", CSIC-UAM, Madrid E-28029, Spain.
Juana M
JM
Gancedo
D019143:Evolution, Molecular; D005686:Galactokinase / Q000235:genetics / Q000378:metabolism; D020440:Gene Duplication; D006593:Hexokinase / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins; D006593:Hexokinase; D005686:Galactokinase