Reduced polymorphism in the Kelch propeller domain in Plasmodium vivax isolates from Cambodia.
Polymorphism in the ortholog gene of the Plasmodium falciparum K13 gene was investigated in Plasmodium vivax isolates collected in Cambodia. All of them were Sal-1 wild-type alleles except two (2/284, 0.7%), and P. vivax K12 polymorphism was reduced compared to that of the P. falciparum K13 gene. Both mutant allele isolates had the same nonsynonymous mutation at codon 552 (V552I) and were from Ratanak Kiri province. These preliminary data should encourage additional studies for associating artemisinin or chloroquine resistance and K12 polymorphism.
Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
Jean
J
Popovici
Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
Sokheng
S
Kao
Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
Leanghor
L
Eal
Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
Sophalai
S
Bin
Institut Pasteur in Cambodia, Phnom Penh, Cambodia.
Saorin
S
Kim
Institut Pasteur in Cambodia, Phnom Penh, Cambodia dmenard@pasteur-kh.org.
Didier
D
Ménard
D018692:Antimanic Agents / Q000627:therapeutic use; D002160:Cambodia / Q000453:epidemiology; D004351:Drug Resistance / Q000235:genetics; D017125:Genes, Protozoan / Q000235:genetics*; D006801:Humans; D016780:Malaria, Vivax / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D010966:Plasmodium vivax / Q000235:genetics*; D011110:Polymorphism, Genetic; D016415:Sequence Alignment
D018692:Antimanic Agents