Sandmeyer difluoromethylation of (hetero-)arenediazonium salts.
A Sandmeyer-type difluoromethylation process has been developed that allows the straightforward conversion of (hetero-)arenediazonium salts into the corresponding difluoromethyl (hetero-)arenes under mild conditions. The actual difluoromethylating reagent, a difluoromethyl-copper complex, is formed in situ from copper thiocyanate and TMS-CF2H. The diazonium salts are either preformed or generated in situ from broadly available aromatic amines.
Department of Organic Chemistry, TU Kaiserslautern , Erwin-Schrödinger-Str. Geb. 54, 67663 Kaiserslautern, Germany.
Christian
C
Matheis
Kévin
K
Jouvin
Lukas J
LJ
Goossen