Skin gangrene as an extraintestinal manifestation of inflammatory bowel disease.
Inflammatory bowel diseases can commonly present many cutaneous lesions which can contribute to the diagnosis of the disease or its activity. The most frequent cutaneous or mucocutaneous manifestations suggesting ulcerative rectocolitis activity are erythema nodosum (3-10%), pyoderma gangrenosum (5-12%) and aphthous stomatitis (4%). Other reactive skin manifestations related to immunological mechanisms associated with the inflammatory bowel disease are: Sweet's syndrome, arthritis-dermatitis syndrome associated with inflammatory bowel disease and leukocytoclastic vasculitis. We describe the case of a young man with diagnosis of ulcerative rectocolitis, which presented an extensive cutaneous gangrene secondary to microvascular thrombosis. The case represents a dermatologic rarity and should be recognized as a cutaneous manifestation related to the hypercoagulability state observed in the disease's activity.
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Yumi Cristina
YC
Komatsu
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Gabriela Cunha
GC
Capareli
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Maria Fernanda Feitosa de Camargo
MF
Boin
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Rute
R
Lellis
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Thaís Helena Proença de
TH
Freitas
Santa Casa de Misericórdia de São Paulo, São Paulo, SP, Brazil.
Karine
K
Simone
D000328:Adult; D001706:Biopsy; D005734:Gangrene / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D011350:Proctocolitis / Q000150:complications*; D012867:Skin / Q000473:pathology*; D013927:Thrombosis / Q000150:complications