Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors.
We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.
Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland BT521SA, UK. j.callan@ulster.ac.uk.
Colin
C
Fowley
Anthony P
AP
McHale
Bridgeen
B
McCaughan
Aurore
A
Fraix
Salvatore
S
Sortino
John F
JF
Callan
D000818:Animals; D002244:Carbon / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008027:Light; D051379:Mice; D008807:Mice, Inbred BALB C; D016513:Mice, SCID; D050997:Nanomedicine; D049329:Nanostructures / Q000737:chemistry*; D009569:Nitric Oxide / Q000737:chemistry* / Q000633:toxicity; D010190:Pancreatic Neoplasms / Q000628:therapy; D017785:Photons; D010789:Phototherapy; D045663:Quantum Dots / Q000737:chemistry*; D014183:Transplantation, Heterologous
D009569:Nitric Oxide; D002244:Carbon