Efficient merging of copper and photoredox catalysis for the asymmetric cross-dehydrogenative-coupling of alkynes and tetrahydroisoquinolines.
A highly efficient catalytic asymmetric alkynylation of prochiral CH2 groups in tetrahydroisoquinoline was developed using copper catalyzed cross-dehydrogenative-coupling of sp(3) and sp C-H bonds with the assistance of a photocatalyst and visible light.
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, Quebec H3A 0B8, Canada. cj.li@mcgill.ca.
Inna
I
Perepichka
Soumen
S
Kundu
Zoë
Z
Hearne
Chao-Jun
CJ
Li