Testosterone treatment of men with mild cognitive impairment and low testosterone levels.
BACKGROUND
This study investigated the effects of testosterone (T) treatment on cognition, mood, and quality of life in men with mild cognitive impairment (MCI) and low serum T levels.


METHODS
A total of 351 community-dwelling men were screened, and 37 men evidenced both MCI and low T of whom 27 agreed for further screening. Twenty-two met all the study inclusion/exclusion criteria and enrolled in a 6-month randomized, double-blind, placebo-controlled study.


RESULTS
Total T levels significantly increased in the T treatment group. No significant changes were observed in measures of cognition, mood, or quality of life other than improvement in 1 objective measure of verbal memory (P < .05) and decreased depression symptoms (P < .02) in the treatment group.


CONCLUSIONS
Testosterone treatment may modestly improve verbal memory and depression symptoms in men with both MCI and low T.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA cherrier@uw.edu.
M M
MM
Cherrier
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
K
K
Anderson
Geriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
J
J
Shofer
Geriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA.
S
S
Millard
Geriatric, Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
A M
AM
Matsumoto
D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000188:drug therapy*; D003863:Depression / Q000188:drug therapy*; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D008875:Middle Aged; D011788:Quality of Life; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D016896:Treatment Outcome
D013739:Testosterone
cognition; low serum testosterone; mild cognitive impairment; quality of life; testosterone treatment; verbal memory