Oxidative stress contributes to muscle atrophy in chronic kidney disease patients.
OBJECTIVE
Patients with chronic kidney disease have impaired muscle metabolism, resulting in muscle atrophy. Oxidative stress has previously been identified as a significant contributor to muscle atrophy in other populations, but the contribution in chronic kidney disease is unknown. The aim of this study was to investigate the association between oxidative stress, grip strength, and lean mass in patients with chronic kidney disease.


METHODS
This is a cross-sectional study of 152 participants with stage 3 or 4 chronic kidney disease. Outcome measures include grip strength, lean mass, plasma total F2-isoprostanes, inflammation, peak oxygen uptake, and standard clinical measures.


RESULTS
Thirty four (22.4%) chronic kidney disease patients had elevated oxidative stress levels (plasma F2-isoprostanes >250 pg/ml), with 82% of patients below age-predicted grip strength normative values. There was a significant negative association between plasma F2-isoprostanes and grip strength (r = -0.251) and lean mass (r = -0.243). There were no associations with inflammation markers. Multiple linear regression identified plasma F2-isoprostanes as a significant predictor of grip strength independent of other predictors: sex, diabetes status, body mass index, body fat percent, and phosphate (adjusted r(2) = 69.5, P < 0.001).


CONCLUSIONS
Plasma F2-isoprostanes were independently associated with reduced strength in chronic kidney disease patients.
Kassia S
KS
Beetham
Erin J
EJ
Howden
David M
DM
Small
David R
DR
Briskey
Megan
M
Rossi
Nicole
N
Isbel
Jeff S
JS
Coombes
D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D028441:F2-Isoprostanes / Q000097:blood; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D050050:Protein Carbonylation; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000378:metabolism* / Q000503:physiopathology
D015415:Biomarkers; D028441:F2-Isoprostanes
Kidney diseases; Muscle strength; Muscular atrophy; Oxidative stress