Brain-derived neurotrophic factor and inflammatory markers in school-aged children with early trauma.
OBJECTIVE
The impact of childhood trauma (CT) on brain-derived neurotrophic factor (BDNF) and cytokines levels remains unclear. We investigated the association between CT and changes in BDNF and cytokines plasma levels in children.


METHODS
We recruited 36 children with trauma (CT+) and 26 children without trauma (CT-). The presence of CT was based on a clinical interview and by Criteria A of DSM-IV criteria for PTSD. Blood samples were drawn from all children to assess BDNF and cytokines. ancova was performed with psychiatric symptoms and BMI as covariates to evaluate group differences in plasma levels.


RESULTS
CT+ showed increased levels of BDNF and TNF-α after excluding children with history of inflammatory disease (P<0.05) when compared with those CT-. IL-12p70, IL-6, IL-8, IL-10, and IL-1β levels were not statistically different between groups.


CONCLUSIONS
CT+ showed increased BDNF and proinflammatory cytokines levels. The increase in BDNF levels may be an attempt to neutralize the negative effects of CT, while an increase in TNF-a levels be associated with a proinflammatory state after CT. How these changes associated with trauma relate to other biological changes and illness trajectory later in life remain to be further studied.
Bipolar Disorder Program and Laboratory of Molecular Psychiatry, National Institute for Translational Medicine, INCT-TM Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
J
J
Bücker
G R
GR
Fries
F
F
Kapczinski
R M
RM
Post
L N
LN
Yatham
P
P
Vianna
J A
JA
Bogo Chies
C S
CS
Gama
P V
PV
Magalhães
B W
BW
Aguiar
B
B
Pfaffenseller
M
M
Kauer-Sant'Anna
D015415:Biomarkers / Q000097:blood; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D016207:Cytokines / Q000097:blood*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D008297:Male; D011599:Psychopathology; D013313:Stress Disorders, Post-Traumatic / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D019208:Brain-Derived Neurotrophic Factor; D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha
BDNF; children; cytokines; trauma