[Progress in the effects of BRAP gene on cardiovascular diseases].
BRAP (BRCA1 associated protein) is one of BRCA1 (Breast cancer suppressor protein) associated cytoplasmic proteins. BRAP gene has been found to be associated with the risk of some cancers, and the associations between BRAP and cardiovascular diseases and metabolic syndrome is gradually attracting much attention. However, the explicit mechanisms involved remain to be fully elucidated. We reviewed the association between BRAP gene and cardiovascular diseases and metabolic syndromes and the biologic mechanisms in the regulation of metabolism, hoping to provide clues on our future researches.
Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Duo
D
Lv
Department of Public Health, Zhejiang University School of Medicine, Hangzhou 310058, China.
Yi-min
YM
Zhu
D002318:Cardiovascular Diseases / Q000235:genetics*; D006801:Humans; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases