Amniotic fluid lamellar body count as a novel biochemical marker for timing elective caesarean delivery.
The aim of this study is to evaluate the performance of amniotic fluid lamellar body count (LBC) on the timing of elective caesarean delivery (CS) at ≥ 39 weeks. After allocating the study group (group I, transient tachypnoea of newborn (TTN), n = 14), an age-matched control group (group II, no TTN, n = 79) was selected for amniotic fluid LBC analysis. The median amniotic fluid LBC levels in group I were significantly lower than in the control group. Furthermore, the median values of mean lamellar body volume, median lamellar body distribution width and lamellar bodycrit in group I were also significantly lower than in group II. The best amniotic fluid LBC value to predict TTN was 40.15 × 10(3)/μl, with 82.3% sensitivity and 64.3% specificity. The favourable sensitivity and specificity values to predict the TTN for amniotic fluid LBC may suggest using it as an elective caesarean delivery-time scheduling marker.
a Department of Obstetrics and Gynecology , Karadeniz Technical University, Faculty of Medicine , Trabzon , Turkey.
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Kart
a Department of Obstetrics and Gynecology , Karadeniz Technical University, Faculty of Medicine , Trabzon , Turkey.
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Guven
a Department of Obstetrics and Gynecology , Karadeniz Technical University, Faculty of Medicine , Trabzon , Turkey.
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Guvendag Guven
b Neonatal Intensive Care Unit, Trabzon Women and Child Health and Maternity Hospital , Trabzon , Turkey.
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Armangil
c Department of Biochemistry , Karadeniz Technical University, Faculty of Medicine , Trabzon , Turkey.
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Mentese
D000328:Adult; D056809:Alveolar Epithelial Cells / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D002585:Cesarean Section / Q000592:standards*; D017558:Elective Surgical Procedures; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011663:Pulmonary Surfactants / Q000378:metabolism; D055815:Young Adult
D015415:Biomarkers; D011663:Pulmonary Surfactants
Amniotic fluid; elective caesarean delivery; lamellar body; transient tachypnoea of newborn