[Effect of sulfated polysaccharides from brown seaweed Laminaria japonica on the morfology of lymfoid organs and functional characteristics of immunocompetent cells].
The effect of sulfated polysaccharide fucoidan from the brown alga Laminaria japonica on morphological characteristics of mouse lymphoid organs, subpopulations of spleen mononuclear leukocytes, cytokine production and cytotoxic activity of splenocytes has been investigated. Fucoidan promoted activation and proliferation of lymphoid hematopoietic cells in primary and secondary immunogenesis bodies, increased expression of markers CD19, NK, NKT, CD25, MHC II, TCR, TLR2 and TLR4, the cytotoxic activity of splenocytes and production of immunoregulatory and proinflammatory cytokines (IL- 2, IL-12, IFN-g, TNF-a, IL-6). This suggests activation of effector mechanisms of innate immunity and adaptive immune responses via the Th-1 type.
E A
EA
lebedynskaya
I D
ID
Makarenkova
O V
OV
Lebedynskaya
N K
NK
Akhmatova
T N
TN
Zvyagintseva
D000818:Animals; D018941:Antigens, CD19 / Q000235:genetics / Q000378:metabolism; D001853:Bone Marrow / Q000033:anatomy & histology / Q000187:drug effects; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D007795:Laminaria / Q000737:chemistry*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000033:anatomy & histology / Q000187:drug effects*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000187:drug effects*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism
D018941:Antigens, CD19; D016207:Cytokines; D010936:Plant Extracts; D011134:Polysaccharides; D051193:Toll-Like Receptors; C007789:fucoidan
cytokines; cytotoxic activity; fucoidan; innate immunity; morphology of lymphoid organs