High APRIL expression correlates with unfavourable survival of gastrointestinal stromal tumour.
A proliferation inducing ligand (APRIL) is a member of the tumour necrosis factor superfamily. High APRIL expression has been found to correlate with tumour development, suggesting that APRIL participates in oncogenesis. However, little is known about APRIL expression in gastrointestinal stromal tumours (GISTs) or the relationship between APRIL expression and the clinical characteristics of GIST. Therefore, we assessed the expression of APRIL immunohistochemically using a tissue microarray from 178 patients with GIST and evaluated the relationship between APRIL expression and patient prognosis. Strong APRIL expression was observed in 42.7% of GISTs, with APRIL expression significantly associated with tumour diameter, gross classification and tumour grade (p < 0.05 each). Kaplan-Meier analysis suggested that low APRIL expression and tumour size <5 cm were associated with longer overall survival. These findings indicate that APRIL expression is correlated with malignant GIST phenotypes and it may serve as an unfavourable prognostic marker in patients with GIST.
1Department of Surgery, Nantong University Affiliated Hospital, Nantong 2Department of Gynaecology and Obstetrics, Nanjing Maternal and Children Care Hospital Affiliated to Nanjing Medical University, Nanjing 3Department of Pathology and Laboratory Medicine, Nantong University Affiliated Hospital, Nantong 4The Key Laboratory of Cancer Biomarkers, Prevention and Treatment Cancer Center and The Key Laboratory of Antibody Technique of Ministry of Health, Nanjing Medical University, Nanjing 5Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Hospital, Nanjing 6Huadong Medical Institute of Biotechnology, Nanjing, China *these authors contributed equally to this work.
Hua
H
Xian
Huilin
H
Zhang
Huijun
H
Zhu
Xudong
X
Wang
Xiaojun
X
Tang
Yuan
Y
Mao
Jin
J
Zhu
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D055815:Young Adult
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C118660:PDS5B protein, human; D014157:Transcription Factors; D019009:Proto-Oncogene Proteins c-kit