Pharmacokinetics of metoclopramide in calves with renal dysfunction.
To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.
Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan.
Mariko
M
Takayasu
Kouko
K
Hamamoto
Hiroshi
H
Satoh
Toshihiro
T
Ichijo
Toru
T
Takahashi
Kazuhisa
K
Furuhama
D000818:Animals; D000932:Antiemetics / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000378:metabolism*; D005919:Glomerular Filtration Rate; D006207:Half-Life; D008026:Ligation; D008787:Metoclopramide / Q000097:blood / Q000493:pharmacokinetics*; D009392:Nephrectomy; D051437:Renal Insufficiency / Q000209:etiology / Q000662:veterinary*
D000932:Antiemetics; D008787:Metoclopramide