Choroid plexus in the eye: a case study.
OBJECTIVE
The purpose of this report is to describe a pediatric case of total retinal detachment (RD) with secondary glaucoma in the setting of posterior coloboma with the metaplastic retinal pigment epithelium showing abrupt transition to choroid plexus tissue.


METHODS
Retrospective case report.


RESULTS
A 3-month-old patient presented with leukocoria and enlarged right eye. She was found to have a funnel RD with anterior displacement of lens-iris diaphragm and secondary glaucoma. Orbital imaging ruled out retinoblastoma, and posterior coloboma was identified. Intraocular pressures remained significantly elevated despite maximal medical therapy on glaucoma drops and transscleral cycloablation, and the eye was enucleated for comfort. Histologic analysis confirmed neovascularization of the iris, total RD, and posterior coloboma with the associated metaplastic retinal pigment epithelium showing abrupt transition to choroid plexus tissue.


CONCLUSIONS
This is the first reported case of choroid plexus in the human eye. A close association of choroid plexus with coloboma and RD raises possibility that this tissue may have functionally contributed to pathogenesis of RD by secreting cerebrospinal fluid within subretinal space.
*Duke Eye Center, Duke University Medical Center, Durham, North Carolina; and †Department of Pathology, Duke University Medical Center, Durham, North Carolina.
Bozho
B
Todorich
Thomas J
TJ
Cummings
Sharon
S
Freedman
D015862:Choroid Diseases / Q000209:etiology*; D002831:Choroid Plexus / Q000473:pathology*; D003103:Coloboma / Q000150:complications*; D015353:Eye Enucleation; D005260:Female; D005901:Glaucoma / Q000209:etiology*; D006801:Humans; D007223:Infant; D007905:Lens Diseases / Q000209:etiology; D057972:Posterior Eye Segment / Q000002:abnormalities*; D012163:Retinal Detachment / Q000209:etiology*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012189:Retrospective Studies