Obesity, adipokines and cancer: an update.
Obesity causes dysfunction of adipose tissue, with resultant chronic inflammation and adverse interplay of various adipokines, sex steroids and endocrine hormones. All these drive tumourigenesis and explain the epidemiological link between obesity and cancer. Over the past decade, the associations among obesity, adipokines and cancer have been increasingly recognized. Adipokines and their respective signalling pathways have drawn much research attention in the field of oncology and cancer therapeutics. This review will discuss the recent advances in the understanding of the association of several adipokines with common obesity-related cancers and the clinical therapeutic implications.
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
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Lee
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
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Woo
Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, Hong Kong.|Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, Hong Kong.|State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong.
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Wang
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.
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Yeung
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.|Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, Hong Kong.|Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, Hong Kong.|State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong.
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Xu
Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.|Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong, Hong Kong.|State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, Hong Kong.
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Lam
D054392:Adipokines / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D020738:Leptin / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D009765:Obesity / Q000378:metabolism / Q000628:therapy*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D054392:Adipokines; D052242:Adiponectin; D006728:Hormones; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D014409:Tumor Necrosis Factor-alpha