SIN3A mutations are rare in men with azoospermia.
A loss of function of the murine Sin3A gene resulted in male infertility with Sertoli cell-only syndrome (SCOS) phenotype in mice. Here, we investigated the relevance of this gene to human male infertility with azoospermia caused by SCOS. Mutation analysis of SIN3A in the coding region was performed on 80 Japanese patients. However, no variants could be detected. This study suggests a lack of association of SIN3A gene sequence variants with azoospermia caused by SCOS in humans.
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
T
T
Miyamoto
Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
E
E
Koh
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
A
A
Tsujimura
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Y
Y
Miyagawa
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
G
G
Minase
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
Y
Y
Ueda
Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
M
M
Namiki
Department of Obstetrics and Gynecology, Asahikawa Medical University, Asahikawa, Japan.
K
K
Sengoku
D000328:Adult; D044466:Asian People / Q000235:genetics; D053713:Azoospermia / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics*; D054331:Sertoli Cell-Only Syndrome / Q000235:genetics*; D056264:Sin3 Histone Deacetylase and Corepressor Complex
D012097:Repressor Proteins; C099683:SIN3A transcription factor; D056264:Sin3 Histone Deacetylase and Corepressor Complex
Azoospermia; SIN3A; Sertoli cell-only syndrome; mutation