Glutathione S-transferase M1 and glutathione S-transferase T1 genotype in chronic pancreatitis: a meta-analysis.
OBJECTIVE
A meta-analysis to determine the association between chronic pancreatitis and glutathione-S transferase (GST) mu 1 (GSTM1) and theta 1 (GSTT1) deletions.


METHODS
Case-control studies concerning the relationship between chronic pancreatitis and GSTM1 or GSTT1 deletions were identified (up to October 2013). Meta-analyses of the association between GSTM1 and GSTT1 genotype and chronic pancreatitis or alcoholic chronic pancreatitis (ACP) were performed.


RESULTS
Seven studies were included in the meta-analysis (650 patients/1382 controls for GSTM1 and 536 patients/1304 controls for GSTT1). There were no significant relationships between GSTM1/GSTT1 and chronic pancreatitis or GSTT1 and ACP. There was a significant association between GSTM1 null genotype and ACP (odds ratio 1.16, 95% confidence intervals 1.03, 1.30).


CONCLUSIONS
The GSTM1 null genotype was significantly associated with ACP risk.
ICU Centre, The Second Xiangya Hospital, Central South University, Changsha, China zhongyanjun2@163.com.
Yanjun
Y
Zhong
Department of Paediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Runmei
R
Zou
Respiratory Department, Anhui Provincial Hospital, Hefei, China.
Jie
J
Cao
Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, China.
Mou
M
Peng
D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D050500:Pancreatitis, Chronic / Q000201:enzymology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017594:Publication Bias; D012307:Risk Factors
D005982:Glutathione Transferase; C413545:glutathione S-transferase T1
Glutathione S-transferase M1; alcohol; chronic pancreatitis; glutathione S-transferase T1; polymorphism