Developmental changes in brain function underlying inhibitory control in autism spectrum disorders.
The development of inhibitory control-the ability to suppress inappropriate actions in order to make goal-directed responses-is often impaired in autism spectrum disorders (ASD). In the present study, we examined whether the impairments in inhibitory control evident in ASD reflect-in part-differences in the development of the neural substrates of inhibitory control from adolescence into adulthood. We conducted a functional magnetic resonance imaging (fMRI) study on the anti-saccade task, a probe of inhibitory control, in high-functioning adolescents and adults with ASD compared to a matched group of typically developing (TD) individuals. The ASD group did not show the age-related improvements in behavioral performance from adolescence to adulthood evident in the typical group, consistent with previous behavioral work. The fMRI results indicated that much of the circuitry recruited by the ASD group was similar to the TD group. However, the ASD group demonstrated some unique patterns, including: (a) a failure to recruit the frontal eye field during response preparation in adolescence but comparable recruitment in adulthood; (b) greater recruitment of putamen in adolescence and precuneus in adolescence and adulthood than the TD group; and (c) decreased recruitment in the inferior parietal lobule relative to TD groups. Taken together, these results suggest that brain circuitry underlying inhibitory control develops differently from adolescence to adulthood in ASD. Specifically, there may be relative underdevelopment of brain processes underlying inhibitory control in ASD, which may lead to engagement of subcortical compensatory processes.
Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Aarthi
A
Padmanabhan
Krista
K
Garver
Kirsten
K
O'Hearn
Natalie
N
Nawarawong
Ran
R
Liu
Nancy
N
Minshew
John
J
Sweeney
Beatriz
B
Luna
D000293:Adolescent; D041923:Adolescent Development / Q000502:physiology; D000328:Adult; D000367:Age Factors; D000067877:Autism Spectrum Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D002657:Child Development / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D012438:Saccades / Q000502:physiology; D055815:Young Adult
adolescence; antisaccade; autism; development; fMRI; inhibitory control