Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells.
Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel diagnosis biomarkers and therapeutic targets. RIP140, a regulator of estrogen receptor, recently has been found to be involved in the tumorigenesis. However, its function in the progression of HCC remains poorly understood. Here, we found that the expression of RIP140 was downregulated in the HCC tissues. Moreover, overexpression of RIP140 in HCC cells inhibited cell proliferation and migration, while downregulation of RIP140 promoted the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, RIP140 interacted with beta-catenin and negatively regulated beta-catenin/TCF signaling. Taken together, our study suggests the suppressive roles of RIP140 in the pathogenesis of HCC.
General Surgery Department, Zhongshan Hospital, General Surgery Institute, Fudan University, Shanghai, 200032, China.
Dexiang
D
Zhang
Yueqi
Y
Wang
Yuedi
Y
Dai
Jiwen
J
Wang
Tao
T
Suo
Hongtao
H
Pan
Han
H
Liu
Sheng
S
Shen
Houbao
H
Liu
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics* / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation / Q000235:genetics; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D000078723:Nuclear Receptor Interacting Protein 1; D015398:Signal Transduction / Q000235:genetics; D051176:beta Catenin / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; C000627127:NRIP1 protein, human; D009687:Nuclear Proteins; D000078723:Nuclear Receptor Interacting Protein 1; D051176:beta Catenin