[Infiltration of the superior vena cava in NSCLC: results of surgical intervention].
The benefits of surgical therapy of locally advanced non-small cell lung cancer (NSCLC) with infiltration of the superior vena cava (SVC) remains controversial. Here we describe our therapeutic approach and results of our intervention.A retrospective analysis of 22 patients with NSCLC who underwent SVC replacement (n = 17) or reconstruction (n = 5) between 1998 and 2013 was performed. Pneumonectomy was necessary in 16 patients, lobectomy in 8. Preoperative chemotherapy was administered to 3 patients, 16 received postoperative radiation treatment. The clinical course and survival were analyzed.Major postoperative morbidities were found in 13 patients. Graft thrombosis did not occur. Thirty-day mortality was 7 % in pneumonectomy patients and 0 % following lobectomy. Local recurrence was found in 4.5 %, distant metastases developed in 54.5 % of the patients (p = 0.0008). One- and five-year survival probabilities for all patients were 63.6 and 27.9 %. Five-year survival probability was 33 % for patients with SVC reconstruction and 25 % for patients with SVC replacement (p = 0.22). Five-year survival rates after pneumonectomy and lobectomy were 21.4 % and 37.5 %, respectively (p = 0.18).Radical resection involving the SVC in carefully selected patients with NSCLC results in excellent local tumor control. Due to the high rate of distant metastases, application of induction and adjuvant chemotherapy should be carefully assessed.
Abteilung Thorax- und Gefäßchirurgie, Klinik Löwenstein, Löwenstein.
T
T
Windisch
Innere Medizin II, Onkologie, Klinik Löwenstein, Löwenstein.
J R
JR
Fischer
Abteilung Thorax- und Gefäßchirurgie, Klinik Löwenstein, Löwenstein.
A
A
Vega
Abteilung Thorax- und Gefäßchirurgie, Klinik Löwenstein, Löwenstein.
S
S
Decker
Abteilung Innere Medizin, Missionsärztliche Klinik, Akademisches Lehrkrankenhaus der Julius-Maximilians-Universität Würzburg.
M
M
Held
Abteilung Thorax- und Gefäßchirurgie, Klinik Löwenstein, Löwenstein.
T P
TP
Graeter
D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology* / Q000628:therapy*; D059248:Chemoradiotherapy / Q000379:methods; D003131:Combined Modality Therapy / Q000379:methods; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011013:Pneumonectomy / Q000379:methods; D012189:Retrospective Studies; D013479:Superior Vena Cava Syndrome / Q000209:etiology* / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D014683:Vena Cava, Superior / Q000473:pathology / Q000601:surgery