Microwave-assisted polyol synthesis of carbon nitride dots from folic acid for cell imaging.
A green, one-step microwave-assisted polyol synthesis was employed to prepare blue luminescent carbon nitride dots (CNDs) using folic acid molecules as both carbon and nitrogen sources. The as-prepared CNDs had an average size of around 4.51 nm and could be well dispersed in water. Under excitation at 360 nm, the CNDs exhibited a strong blue luminescence and the quantum yield was estimated to be 18.9%, which is greater than that of other reported CNDs. Moreover, the CNDs showed low cytotoxicity and could efficiently label C6 glioma cells, demonstrating their potential in cell imaging.
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China.
Weiwei
W
Guan
Department of Chemical Biology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China.
Wei
W
Gu
Department of Chemical Biology, School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing, People's Republic of China.
Ling
L
Ye
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China.
Chenyang
C
Guo
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China.
Su
S
Su
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China ; Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing, People's Republic of China.
Pinxiang
P
Xu
Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, People's Republic of China ; Beijing Laboratory for Biomedical Detection Technology and Instrument, Beijing, People's Republic of China.
Ming
M
Xue
D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000633:toxicity; D005492:Folic Acid / Q000737:chemistry*; D008872:Microwaves; D036103:Nanotechnology; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry*; D061848:Optical Imaging; D011108:Polymers / Q000737:chemistry*; D045663:Quantum Dots / Q000737:chemistry* / Q000633:toxicity; D051381:Rats
D005456:Fluorescent Dyes; D009570:Nitriles; D011108:Polymers; C024617:polyol; C011206:cyanogen; D005492:Folic Acid
carbon nitride dots (CNDs); cell imaging; folic acid; photoluminescence