Functional fission of parvalbumin interneuron classes during fast network events.
Fast spiking, parvalbumin (PV) expressing hippocampal interneurons are classified into basket, axo-axonic (chandelier), and bistratified cells. These cell classes play key roles in regulating local circuit operations and rhythmogenesis by releasing GABA in precise temporal patterns onto distinct domains of principal cells. In this study, we show that each of the three major PV cell classes further splits into functionally distinct sub-classes during fast network events in vivo. During the slower (<10 Hz) theta oscillations, each cell class exhibited its own characteristic, relatively uniform firing behavior. However, during faster (>90 Hz) oscillations, within-class differences in PV interneuron discharges emerged, which segregated along specific features of dendritic structure or somatic location. Functional divergence of PV sub-classes during fast but not slow network oscillations effectively doubles the repertoire of spatio-temporal patterns of GABA release available for rapid circuit operations.
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Csaba
C
Varga
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Mikko
M
Oijala
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Jonathan
J
Lish
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Gergely G
GG
Szabo
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Marianne
M
Bezaire
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Ivan
I
Marchionni
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States.
Peyman
P
Golshani
Department of Anatomy and Neurobiology, University of California, Irvine, Irvine, United States.
Ivan
I
Soltesz
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003712:Dendrites / Q000502:physiology; D005260:Female; D065818:Gamma Rhythm / Q000502:physiology; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D008297:Male; D008810:Mice, Inbred C57BL; D008959:Models, Neurological; D010320:Parvalbumins / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D017966:Pyramidal Cells / Q000502:physiology; D012146:Rest; D013826:Theta Rhythm / Q000502:physiology
D010320:Parvalbumins
in vivo; inhibition; mouse; neuroscience; oscillation