Expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma and their clinical significance.
OBJECTIVE
The purpose of the study was to detect the expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma, and to evaluate their roles in the carcinogenesis of gastric adenocarcinoma, development, invasion and metastasis as well as their clinical significance.


METHODS
The expression of SNCG, MAP2, SDF-1 and CXCR4 was detected by SP immunohistochemical method in 225 cases of gastric adenocarcinoma and 105 cases of nonneoplastic adjacent gastric tissue. The expression of SNCG, MAP2, SDF-1 and CXCR4 mRNA was also detected by RT-PCR method in 50 cases of gastric adenocarcinoma and 30 cases of nonneoplastic adjacent gastric tissue.


RESULTS
The expression of SNCG, MAP2, SDF-1 and CXCR4 in the gastric adenocarcinoma was remarkably higher than those in the nonneoplastic adjacent gastric tissue (P < 0.01); The positive expression of SNCG and MAP2 was correlated with the depth of tumor invasion and the metastasis of lymph nodes (P < 0.05), and that of SDF-1 and CXCR4 was correlated with the metastasis of lymph nodes (P < 0.05).


CONCLUSIONS
SNCG, MAP2, SDF-1 and CXCR4 may play an important role in the carcinogenesis, progression, invasion and metastasis of gastric adenocarcinoma. However, it still needs more exploration whether they can serve as promising therapeutic targets of gastric adenocarcinoma.
Department of Pathology, Affiliated Hospital of Logistics College of The Chinese People's Armed Police Force 220 Chenglin Road, Hedong District, Tianjin 300162, People's Republic of China.
Shufang
S
Zheng
Department of Pathology, Affiliated Hospital of Logistics College of The Chinese People's Armed Police Force 220 Chenglin Road, Hedong District, Tianjin 300162, People's Republic of China.
Lifang
L
Shi
Postgraduate Training Center for Liaoning Medical College in Affiliated Hospital of Logistics College, The Chinese People's Armed Police Force 220 Chenglin Road, Hedong District, Tianjin 300162, People's Republic of China.
Yi
Y
Zhang
Department of Pathology, Affiliated Hospital of Logistics College of The Chinese People's Armed Police Force 220 Chenglin Road, Hedong District, Tianjin 300162, People's Republic of China.
Tao
T
He
D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics / Q000556:secondary; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008869:Microtubule-Associated Proteins / Q000032:analysis* / Q000235:genetics; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D019718:Receptors, CXCR4 / Q000032:analysis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000235:genetics / Q000473:pathology; D051845:gamma-Synuclein / Q000032:analysis* / Q000235:genetics
D014408:Biomarkers, Tumor; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; C489788:MAP2 protein, human; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D019718:Receptors, CXCR4; C104249:SNCG protein, human; D051845:gamma-Synuclein
CXCR4; MAP2; RT-PCR; SDF-1; SNCG; gastric adenocarcinoma; immunohistochemistry