Sensitivity and specificity of hypopnoea detection using nasal pressure in the presence of a nasal expiratory resistive device (Provent®).
Nasal expiratory resistive valves (Provent(®)) have been proposed as novel therapy for obstructive sleep apnea. We compared pressure measurements from a standard nasal pressure catheter used to assess nasal airflow during sleep with those from nasal expiratory resistive device with attached proprietary nasal pressure cannula. Nasal pressure cannula or Provent(®) + proprietary nasal pressure cannula were attached to a bench model of human anterior nares and nasal passages, and pressure measured (P). Respiratory airflows generated by a subject breathing were applied to rear of model and airflow (V) measured via pneumotachograph. Airflow amplitude (ΔV) was plotted against pressure amplitude (ΔP). Hypopnoea detection (<50% ΔV) sensitivity and specificity was tested by expressing ΔP in terms of two reference breaths: reference breath 1, ΔV 0.55 L s(-1) = 100%; and reference breath 2, ΔV 0.45 L s(-1) = 100%. ΔP/ΔV relationships were linear for ΔV ≤ 0.55 L s(-1); ΔP = 0.37ΔV + 0.16 (nasal pressure cannula), ΔP = 2.7ΔV + 0.12 (Provent(®) + proprietary nasal pressure cannula); both R(2) > 0.65, p < 0.0001; p < 0.0001 for between slope difference). For nasal pressure cannula, specificity of hypopnoea detection differed between reference breaths one and two (80.2% and 40.0%, respectively), and Provent(®) + proprietary nasal pressure cannula (30.3% and 74.2%, respectively). Quantification of airflow obstruction in the presence of Provent(®) + proprietary nasal pressure cannula is greatly influenced by the reference breath chosen to determine a reduction in nasal airflow. Reported variability in therapeutic response to nasal expiratory resistive devices may relate to differences in measurement technique specificity used to quantify the severity of sleep disordered breathing.
Department of Respiratory and Sleep Medicine at Westmead Hospital, Westmead, Sydney, NSW 2145, Australia.
Stephen
S
Milne
Terence C
TC
Amis
John R
JR
Wheatley
Kristina
K
Kairaitis
D057785:Catheters; D045853:Exhalation; D006801:Humans; D057446:Hydrodynamics; D009296:Nasal Cavity; D011312:Pressure; D012680:Sensitivity and Specificity; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology