Sequential Sonagashira and Larock indole synthesis reactions in a general strategy to prepare biologically active β-carboline-containing alkaloids.
A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analogues for optimization and analysis of their biological properties.
The Scripps Research Institute, Translational Research Institute and Department of Chemistry, Jupiter, Florida 33458, United States.
Xiaohong
X
Pan
The Scripps Research Institute, Translational Research Institute and Department of Chemistry, Jupiter, Florida 33458, United States.
Thomas D
TD
Bannister
D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D001688:Biological Products; D002243:Carbolines; D026121:Indole Alkaloids; D010165:Palladium