[Sickle cell disease: pneumococcus escapes prevention and adapts to the disease. Consequences on vaccine design].
Institut Cochin, Inserm U1016, CNRS UMR 8104, Université René Descartes, Paris V, département de génétique, développement et pathologie moléculaire, Institut Cochin, 24, rue du Faubourg Saint-Jacques, 75014 Paris, France.
Dominique
D
Labie
Inserm UMR 1134, Université Paris Diderot, Sorbonne Paris Cité ; laboratoire d'excellence sur le globule rouge (GR-Ex), hôpital Robert Debré et Institut national de la transfusion sanguine, Paris, France.
Jacques
J
Elion
D000222:Adaptation, Physiological / Q000235:genetics / Q000276:immunology; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000378:metabolism / Q000382:microbiology; D000818:Animals; D019072:Antibiotic Prophylaxis; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology; D001692:Biological Transport / Q000235:genetics; D002353:Carrier State / Q000382:microbiology; D002675:Child, Preschool; D003165:Complement System Proteins / Q000172:deficiency; D004195:Disease Models, Animal; D015195:Drug Design; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007223:Infant; D007501:Iron / Q000097:blood; D055442:Metabolome; D051379:Mice; D009305:Nasopharynx / Q000382:microbiology; D010403:Penicillin Resistance / Q000235:genetics; D011008:Pneumococcal Infections / Q000150:complications* / Q000235:genetics / Q000382:microbiology / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000235:genetics / Q000276:immunology; D012641:Selection, Genetic; D013296:Streptococcus pneumoniae / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins; D022242:Pneumococcal Vaccines; D011135:Polysaccharides, Bacterial; D003165:Complement System Proteins; D007501:Iron