[Impact of isolated diastolic hypertension on new-onset cardiovascular and cerebro-vascular diseases].
OBJECTIVE
To explore the impact of isolated diastolic hypertension (IDH) on new-onset cardio-cerebral vascular diseases (CVD).


METHODS
This cohort study involved 101 510 participants who were employees of the Kailuan Group-a state-run coal mining company, in 2006 and 2007. Among them, 6 780 subjects were diagnosed with IDH, 35 448 subjects were diagnosed with high-normal blood pressure and 19 460 subjects were diagnosed with normal tension. However, none of them had the history of either cardio-cerebral vascular disease or malignant cancer. Cardio-cerebral vascular events including cerebral infarction, cerebral hemorrhage, acute myocardial infarction were recorded every 6 months during the follow-up (47.1 ± 4.8) period. Multivariable Cox proportional hazards regression models were used to analyze the risk factors of first-ever CVD events.


RESULTS
1) There were 675 CVD events occurred during the follow-up period. The incidence rates of CVD events (1.7% vs. 0.9%), cerebral infarction (1.0% vs. 0.6%) and cerebral hemorrhage (0.4% vs. 0.1%) were significantly higher in IDH group than that in the normal tension group (all P < 0.05). 2) After adjustment for other established CVD risk factors, the hazards ratios became 1.67 (95% CI: 1.28-2.17) for total CVD events and 1.59 (95% CI: 1.12-2.27) for cerebral infarction and 2.67 (95% CI: 1.54-4.65) for cerebral hemorrhage in the IDH group. 3). In stratified analysis on age, after adjustment for other established CVD risk factors, the hazards ratio was 2.22 (95% CI: 1.41-3.50) for cerebral infarction in lower 60 years old group, while the it was 7.27 (95% CI: 2.58-20.42) for cerebral hemorrhage in groups older than 60 years of age.


CONCLUSIONS
IDH was the independent risk factor for the total cardio-cerebral vascular events, on both cerebral infarction and cerebral hemorrhage. The predicted values of IDH for different CVD events were diverse on different age groups.
College of Nursing and Rehabilitation of Hebei United University, Tangsha 063000, China; Yanbian University.
Fengmei
F
Xing
Linxi Hospital, the Affiliated Kailuan Genneral Hospital.
Yan
Y
Dong
Graduate School of Hebei United University.
Jie
J
Tao
Graduate School of Hebei United University.
Xinying
X
Gao
Linxi Hospital, the Affiliated Kailuan Genneral Hospital.
Jianhui
J
Zhou
Department of Cardiology of Kailuan Genneral Hospital.
Shuohua
S
Chen
Graduate School of Hebei United University.
Chunpeng
C
Ji
Linxi Hospital, the Affiliated Kailuan Genneral Hospital.
Tao
T
Yao
Department of Cardiology of Kailuan Genneral Hospital. Email: drwusl@163.com.
Shouling
S
Wu
D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors