[Expressions of aquaporin-4, matrix metallo-proteinase-2 and matrix metallo-proteinase-14 in peritumor edematous zone of glioma and clinical implications].
OBJECTIVE
To distinguish the expressions of matrix metallo-poteinase and aquaporin in peritumor edematous zone and normal brain tissue for different pathological levels of glioma and explore the relationship of glioma cell invasiveness and brain edema.


METHODS
The immunohistochemical method of SP was employed to detect the expressions of aquaporin-4 (AQP-4), matrix metallo-proteinase-2 (MMP-2) and matrix metallo-proteinase-14 (MMP-14) in glioma and normal brain tissue. Due to a rarity of glioma Grades I and II, grades I and II glioma were pooled into low malignancy group (LMG) and grades III and IV into high malignancy group (HMG). The software program SPSS 11.0 was used for Kolmogorov-Smirnov test of independent samplets. The differences were detected between normal brain tissue and LMG and HMG. Also the relationship of AQP4, MMP-2 and MMP-14 was analyzed.


RESULTS
With the advancing pathological grades of glioma, the expression of AQP-4, MMP-2 and MMP-14 were higher in positive areas. There were significant deviations among 3 groups.


CONCLUSIONS
The expressions of AQP-4, MMP-2 and MMP-14 in normal brain tissue and all levels of glioma edema are positively correlated. And there is a close correlation between glioma invasiveness and edema extent.
The Department of Neurosurgery, Henanxinxiang Center Hospital, Xinxiang 453000, China.
Yang
Y
Wang
Shusen
S
Guan
Gang
G
Zhao
Pengqiang
P
Shi
Email: king13837368673@163.com.
Jinzhong
J
Wang
D051401:Aquaporin 4 / Q000378:metabolism*; D001929:Brain Edema / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D053511:Matrix Metalloproteinase 14 / Q000378:metabolism*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9
C496030:AQP4 protein, human; D051401:Aquaporin 4; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; C507086:MMP14 protein, human; D053511:Matrix Metalloproteinase 14