[Children with hyperthyroidism due to elevated hCG levels].
We describe two children with hyperthyroidism secondary to elevated hCG levels: one patient with gestational trophoblastic disease and one patient with choriocarcinoma. hCG resembles other glycoproteins that can lead to hyperthyroidism through TSH receptor activation. Also, through its LH-mimicking effect, hCG can induce high oestradiol levels, resulting in stormy pubertal development. False negative hCG tests due to the high-dose hook effect may complicate the diagnostic process. In patients with antibody-negative thyrotoxicosis, the diagnosis of hCG-induced hyperthyroidism must be considered.
Tergooi, afd. Kindergeneeskunde, Blaricum.
Jasper J
JJ
Jöbsis
A S Paul
AS
van Trotsenburg
Johannes H M
JH
Merks
Gerdine A
GA
Kamp
D000293:Adolescent; D002648:Child; D006063:Chorionic Gonadotropin / Q000097:blood*; D003937:Diagnosis, Differential; D005260:Female; D031901:Gestational Trophoblastic Disease / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis* / Q000209:etiology; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D011247:Pregnancy
D006063:Chorionic Gonadotropin