Fosfomycin for the treatment of prostate infection.
A 69-year-old man with diabetes mellitus was diagnosed with a prostate abscess. Although the pathogen was fluoroquinolone-resistant Escherichia coli and the oral administration of trimethoprim-sulfamethoxazole was initiated, the infection recurred after three months. The antibiotic therapy was subsequently changed to intravenous fosfomycin, and the patient's condition promptly improved. Four weeks of fosfomycin therapy was successfully continued without any adverse events. In the era of antibiotic resistance, revival of forgotten drugs is an important issue for clinicians. Fosfomycin can be applied as an alternative option for prostate infections, considering the remaining susceptibility of multidrug-resistant pathogens to fosfomycin and the good pharmacokinetics of this drug in prostatic tissue.
Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Hideharu
H
Hagiya
Megumi
M
Ninagawa
Kou
K
Hasegawa
Tomohiro
T
Terasaka
Kosuke
K
Kimura
Koichi
K
Waseda
Yoshihisa
Y
Hanayama
Toshiaki
T
Sendo
Fumio
F
Otsuka
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005578:Fosfomycin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011469:Prostatic Diseases / Q000188:drug therapy* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D005578:Fosfomycin