Neuroimmunology: towards more-accurate diagnosis in neuromyelitis optica.
Neuromyelitis optica spectrum disorders (NMOSD) can mimic multiple sclerosis (MS). Avoiding misdiagnosis is crucial, because some disease-modifying drugs for MS can aggravate NMOSD, causing blindness and paraplegia. A recent study reports that misdiagnosis of NMOSD as MS occasionally occurs, and that a two-step antibody assay could improve differential diagnosis.
Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, Aobaku, Sendai 980-8574, Japan.
Kazuo
K
Fujihara
Nuffield Department of Clinical Neurosciences, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK.
Jacqueline
J
Palace
D051401:Aquaporin 4 / Q000378:metabolism; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D015213:Neuroimmunomodulation / Q000502:physiology; D009471:Neuromyelitis Optica / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology
C496030:AQP4 protein, human; D051401:Aquaporin 4; D007074:Immunoglobulin G