ParadYm shift: Ym1 and Ym2 as innate immunological regulators of IL-17.
Chitinase-like proteins are associated with type 2 immune responses and the ‘wound-healing’ pathway, but their role has remained unclear. Studies have now highlighted their contribution to IL-17 production and their link to neutrophil activity required for the control of helminth infection.
Department of Pathobiology and the Department of Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Gaia
G
Muallem
Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher A
CA
Hunter
D000818:Animals; D000071451:Chitinase-3-Like Protein 1; D002688:Chitinases / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology*; D037102:Lectins / Q000276:immunology*; D009349:Nematode Infections / Q000276:immunology*; D020556:Neutrophil Infiltration / Q000276:immunology*; D001619:beta-N-Acetylhexosaminidases / Q000276:immunology*
C509289:Chil1 protein, mouse; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins; D002688:Chitinases; C525260:Ym2 protein, mouse; C429541:Chil3 protein, mouse; D001619:beta-N-Acetylhexosaminidases