The relationship between obsessive-compulsive symptoms and PARKIN genotype: The CORE-PD study.
BACKGROUND
Few studies have systematically investigated the association between PARKIN genotype and psychiatric co-morbidities of Parkison's disease (PD). PARKIN-associated PD is characterized by severe nigral dopaminergic neuronal loss, a finding that may have implications for behaviors rooted in dopaminergic circuits such as obsessive-compulsive symptoms (OCS).


METHODS
The Schedule of Compulsions and Obsessions Patient Inventory (SCOPI) was administered to 104 patients with early-onset PD and 257 asymptomatic first-degree relatives. Carriers of one and two PARKIN mutations were compared with noncarriers.


RESULTS
Among patients, carriers scored lower than noncarriers in adjusted models (one-mutation: 13.9 point difference, P = 0.03; two-mutation: 24.1, P = 0.001), where lower scores indicate less OCS. Among asymptomatic relatives, a trend toward the opposite was seen: mutation carriers scored higher than noncarriers (one mutation, P = 0.05; two mutations, P = 0.13).


CONCLUSIONS
First, a significant association was found between PARKIN mutation status and obsessive-compulsive symptom level in both PD and asymptomatic patients, suggesting that OCS might represent an early non-motor dopamine-dependent feature. Second, irrespective of disease status, heterozygotes were significantly different from noncarriers, suggesting that PARKIN heterozygosity may contribute to phenotype. © 2014 International Parkinson and Movement Disorder Society.
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Madeleine E
ME
Sharp
Elise
E
Caccappolo
Helen
H
Mejia-Santana
Ming-X
MX
Tang
Llency
L
Rosado
Martha
M
Orbe Reilly
Diana
D
Ruiz
Elan D
ED
Louis
Cynthia
C
Comella
Martha
M
Nance
Susan
S
Bressman
William K
WK
Scott
Caroline
C
Tanner
Cheryl
C
Waters
Stanley
S
Fahn
Lucien
L
Cote
Blair
B
Ford
Michael
M
Rezak
Kevin
K
Novak
Joseph H
JH
Friedman
Ronald
R
Pfeiffer
Haydeh
H
Payami
Eric
E
Molho
Stuart A
SA
Factor
John
J
Nutt
Carmen
C
Serrano
Maritza
M
Arroyo
Michael W
MW
Pauciulo
William C
WC
Nichols
Lorraine N
LN
Clark
Roy N
RN
Alcalay
Karen S
KS
Marder
D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009771:Obsessive-Compulsive Disorder / Q000209:etiology / Q000235:genetics*; D010300:Parkinson Disease / Q000150:complications / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D044767:Ubiquitin-Protein Ligases; C111567:parkin protein
Parkinson's; neuropsychological; obsessive-compulsive; parkin