The emergent reversal of coagulopathies encountered in neurosurgery and neurology: a technical note.
It is imperative for neurologists, neurosurgeons, and neurointensivists to know how to stop life-threatening hemorrhage in both surgical and non-surgical patients. However, knowing how to medically correct a coagulopathy has become increasingly challenging as more contemporary and sophisticated anticoagulation agents are developed and prescribed. In a time-sensitive and life-threatening situation, where there is little margin for error, the neurosurgeon may not have ready access to information about the drug or condition that caused the coagulopathy or the information on how to treat it. This thorough review of the literature provides a comprehensive overview of the medications and conditions that can lead to persistent and/or life-threatening intracranial hemorrhage.
Department of Neurosurgery, University of Wisconsin Hospital and Clinics, Madison, Wisconsin medow@neurosurgery.wisc.edu.
Joshua Eric
JE
Medow
Department of Pharmacy, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
Matthew R
MR
Dierks
Department of Hematology, University of Wisconsin Hospital and Clinics, Madison, Wisconsin.
Eliot
E
Williams
Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.
J Christopher
JC
Zacko
D004211:Disseminated Intravascular Coagulation / Q000517:prevention & control*; D006801:Humans; D020300:Intracranial Hemorrhages / Q000517:prevention & control*; D019635:Neurosurgical Procedures
Anticoagulants; Coagulopathy; Intracerebral hemorrhage; Neurosurgery; Reversal