Drug induced erythema multiforme: two case series with review of literature.
Erythema Multiforme, (EM) an uncommon, acute inflammatory reactive mucocutaneous disorder and primary allergies confined to the oral mucosa. However the subsequent attacks can produce more severe forms of EM involving the skin. Manifestations of EM are varied and present a diagnostic dilemma because infections (particularly herpes simplex and mycoplasma pneumoniae) and drugs seem to predispose towards development of EM. We report two cases of EM in which drugs (Dioclofenac sodium & Amoxycilline) seems to be precipitating factor. In addition, the article reviews various aspects of EM as relevant to dental practice and highlight the associated potential etiologic agents, pathogenic mechanisms and therapies.
Senior Lecturer, Department of Oral and Maxillofacial Pathology, KM Shah Dental Collage & Hospital , SumandeepVidyapeeth, Vadodara, Gujarat, India .
Shreyas N
SN
Shah
Reader, Department of Oral Pathology, Government Dental Collage & Hospital , Jamnagar, Gujarat, India .
Girish R
GR
Chauhan
Professor, Department of Oral and Maxillofacial Pathology, KM Shah Dental Collage & Hospital , SumandeepVidyapeeth, Vadodara, Gujarat, India .
B S
BS
Manjunatha
Senior Lecturer, Department of Oral and Maxillofacial Pathology, KM Shah Dental Collage & Hospital , SumandeepVidyapeeth, Vadodara, Gujarat, India .
Kapil
K
Dagrus
Dermatostomatitis; Erythema Multiforme; Steven johnson syndrome; Toxic epidermal necrolysis