Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis.
Microtubules can target proteins such as Connexin43 to plasma membrane subdomains. Patel et al. (2014) now show that the structural desmosome complex participates in targeted trafficking of membrane components through interactions between the microtubule network and the N terminus of desmoplakin, a region that is a pathogenic mutation hotspot.
Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: robin.shaw@cshs.org.
Robin M
RM
Shaw
D000818:Animals; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000235:genetics*; D018031:Connexin 43 / Q000378:metabolism*; D051180:Desmoplakins / Q000378:metabolism*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*
D018031:Connexin 43; D051180:Desmoplakins; D008869:Microtubule-Associated Proteins