Concomitant angiosarcoma and lymphoproliferative disorder in solid organ transplant recipients.
An increased risk of posttransplant malignancy has been consistently reported following various solid organ transplants. The malignancies most commonly encountered are non-melanoma skin cancers, carcinomas of lung or breast and posttransplant lymphoproliferative disorders. Angiosarcoma, an uncommon vascular mesenchymal neoplasm, is rare in the posttransplant setting. This report describes two patients who developed high-grade angiosarcoma following a solid organ transplant. Notably, in both patients, the diagnosis of angiosarcoma was preceded by diagnosis of a lymphoproliferative disorder with monoclonal immunoglobulin heavy chain rearrangement.
Division of Hematology and Oncology, Stony Brook Medicine, New York, NY USA.
Lea N
LN
Baer
Division of Hematology and Oncology, New York- Presbyterian, New York, NY USA.
David G
DG
Savage
Department of Pathology, New York-Presbyterian, New York, NY USA.
Hanina H
HH
Hibshoosh
Division of Hematology and Oncology, New York- Presbyterian, New York, NY USA.
Kevin
K
Kalinsky
Angiosarcoma; Posttransplant lymphoproliferative disorder; Solid organ transplant