[Low-grade gliomas in adults].
Low-grade gliomas (LGG) are brain tumors with a low or intermediate biological aggressiveness. According to histopathological features, they are further specified as grade I or II by WHO criteria. Diffuse astrocytomas, oligodendrogliomas, and mixed gliomas are the most common LGG. They mainly affect young patients in their 3rd to 5th decade and often manifest with epileptic seizures. A macroscopically complete or near-complete tumor resection that does not induce additional neurological deficits, is recommended as first line therapy in surgically accessible tumors, as a significant benefit for overall survival has been demonstrated. The indication for adjuvant chemo- or radiotherapy must be discussed interdisciplinary in each case. MGMT promotor methylation, LOH 1p/19q, as well as the status of somatic mutations within IDH1/2 gene constitute biomarkers that may predict response to adjuvant therapy and may correlate to overall survival. These and other biomarkers could be of benefit in future managing plans to offer patients with LGG an individually tailored, optimal treatment.
Klinik für Neurochirurgie, Kantonsspital St. Gallen und Klinik für Neurochirurgie, Charité - Universitätsmedizin Berlin, Berlin, Deutschland.
Tobias
T
Kratzsch
Service de Neurochirugie et Faculté de Médecine, Hôpitaux Universitaires de Genève.
Oliver P
OP
Gautschi
Klinik für Neurochirurgie, Klinikum Ernst von Bergmann, Potsdam, Deutschland.
Susanne A
SA
Kuhn
Klinik für Neurologie, Abteilung für Neuro-Onkologie, CHUV, Lausanne.
Andreas F
AF
Hottinger
Klinik für Neurochirurgie, Kantonsspital St. Gallen.
Gerhard
G
Hildebrandt
Klinik für Neurochirurgie, Kantonsspital St. Gallen.
Martin N
MN
Stienen
D000328:Adult; D001706:Biopsy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005910:Glioma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed
Hirntumor; biomarqueurs moléculaires; brain tumor; gliome de bas grade; low-grade glioma; molecular biomarkers; molekulare Biomarker; niedrig-gradiges Gliom; personalisierte Tumortherapie; personalized tumor therapy; thérapie anti-tumorale personnalisée; tumeur cérébrale