Synthesis of polysubstituted pyrazoles by a platinum-catalyzed sigmatropic rearrangement/cyclization cascade.
A highly efficient Pt-catalyzed [3,3] sigmatropic rearrangement/cyclization cascade of N-propargylhydrazones is reported. The process provides expedient access to a variety of highly functionalized pyrazoles. The substrate has good substituted group compatibility, and the bioactive 3-CF3 pyrazoles could be synthesized easily with this method.
Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University , Xiamen 361005, Fujian, P. R. China.
Jia-Jie
JJ
Wen
Hai-Tao
HT
Tang
Kai
K
Xiong
Zong-Cang
ZC
Ding
Zhuang-Ping
ZP
Zhan