Impact of p73 gene polymorphism on cancer susceptibility: a meta analysis.
Previous studies examining the association between p73 G4A and gastric cancer risk have produced inconsistent results. The objective of this study was to clarify whether p73 G4A plays a major role in the development of gastric cancer. Studies that had examined the association between p73 G4A and gastric cancer risk were identified through PubMed, Science Direct, and CNKI. We selected eligible studies based on inclusion criteria. Odds ratios were estimated using distinct genetic models, and the heterogeneity between studies was explored using Cochran's Q statistic along with the I(2) statistic. Overall, we found no evidence of a significant association between p73 G4A and risk of gastric cancer. A same trend was also indicated in subgroup analysis by ethnicity. The heterogeneity tests revealed that there was no significant heterogeneity across studies. Our meta-analysis indicates that p73 G4A might not have a major effect on risk of gastric cancer. A much larger study is required to validate our findings.
Department of Gastroenterology, Peking University Third Hospital, Peking University Health Science Center 49 North Garden Rd., Haidian District, Beijing 100191, P. R. China.
Yixuan
Y
Liu
Department of Oncology, General Hospital of PLA 28 Fuxing Rd., Haidian District, Beijing 100853, China.
Weiwei
W
Dong
Department of Surgery, PLA 252 Hospita Baoding 071000, China.
Quan
Q
Mou
Department of Intensive Care Unit, Peking University Third Hospital, Peking University Health Science Center 49 North Garden Rd., Haidian District, Beijing 100191, P. R. China.
Yuxin
Y
Leng
Department of Gastroenterology, Peking University Third Hospital, Peking University Health Science Center 49 North Garden Rd., Haidian District, Beijing 100191, P. R. China.
Lu
L
Zhang
Department of Gastroenterology, Peking University Third Hospital, Peking University Health Science Center 49 North Garden Rd., Haidian District, Beijing 100191, P. R. China.
Liping
L
Duan
D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D025521:Tumor Suppressor Proteins
gastric cancer; p73; polymorphism