Incidence of noninfectious endophthalmitis after intravitreal injection of preservative-free triamcinolone acetonide.
OBJECTIVE
To determine the incidence of noninfectious inflammatory endophthalmitis after preservative-free intravitreal triamcinolone acetonide (PF-IVTA) injection.


METHODS
We performed a retrospective interventional case series, reviewing the medical records of all patients receiving PF-IVTA injection from July 1, 2006, through December 31, 2006; 444 patients were identified who received a total of 502 PF-IVTA injections. Demographic information and details of postinjection inflammation or endophthalmitis were collected.


RESULTS
Eleven eyes (2.2%) of 11 patients (2.5%) had an inflammatory reaction after PF-IVTA injection. Complete obscuration of all fundus details was observed in seven eyes, while moderate inflammation was noted in four eyes. An inflammatory hypopyon, thought not to represent particles of triamcinolone, was seen in eight eyes. The indication for IVTA injection was cystoid macular edema in seven eyes.


CONCLUSIONS
Postinjection inflammatory reactions are not uncommon after PF-IVTA injection. Noninfectious endophthalmitis after IVTA injection appears to be more common in eyes being treated for cystoid macular edema.
From the *Department of Ophthalmology, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey; and the †Retina-Vitreous Center, P.A., New Brunswick, New Jersey.
Daniel B
DB
Roth
Jonathan L
JL
Prenner
Orest
O
Krajnyk