Fructose-1,6-bisphosphate aldolase (FBA)-a conserved glycolytic enzyme with virulence functions in bacteria: 'ill met by moonlight'.
Moonlighting proteins constitute an intriguing class of multifunctional proteins. Metabolic enzymes and chaperones, which are often highly conserved proteins in bacteria, archaea and eukaryotic organisms, are among the most commonly recognized examples of moonlighting proteins. Fructose-1,6-bisphosphate aldolase (FBA) is an enzyme involved in the Embden-Meyerhof-Parnas (EMP) glycolytic pathway and in gluconeogenesis. Increasingly, it is also recognized that FBA has additional functions beyond its housekeeping role in central metabolism. In the present review, we summarize the current knowledge of the moonlighting functions of FBA in bacteria.
*Molecular Bacteriology and Immunology Group, School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.
Fariza
F
Shams
*Molecular Bacteriology and Immunology Group, School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.
Neil J
NJ
Oldfield
*Molecular Bacteriology and Immunology Group, School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.
Karl G
KG
Wooldridge
*Molecular Bacteriology and Immunology Group, School of Life Sciences, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, U.K.
David P J
DP
Turner
D001419:Bacteria / Q000145:classification / Q000201:enzymology / Q000472:pathogenicity*; D005634:Fructose-Bisphosphate Aldolase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D010958:Plasminogen / Q000378:metabolism; D011485:Protein Binding; D014774:Virulence
D010958:Plasminogen; D005634:Fructose-Bisphosphate Aldolase