Genetics, neuroscience, and psychopathology: clothing the emperor.
This ground-breaking series of articles reports findings from genome-wide analyses of endophenotypic indicators of psychopathology including electrocortical activity/reactivity, electrodermal and startle blink responses, and neurocognitive task performance. Findings challenge the long-held notion that endophenotypes more clearly reflect the impact of specific genes than referent clinical phenotypes. Implications for the concept of endophenotypes and biological psychopathology research more broadly are discussed.
Department of Psychology, Florida State University, Tallahassee, Florida, USA.
Christopher J
CJ
Patrick
D058068:Endophenotypes; D055106:Genome-Wide Association Study; D023281:Genomics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D009488:Neurosciences
Endophenotypes; Genetics; Genome; Neuroscience; Psychophysiology; Twins