Multifocal choroiditis in siblings.
OBJECTIVE
To describe multifocal choroiditis in two siblings.


METHODS
Retrospective case reports.


RESULTS
Two sisters presented 10 years apart with multifocal choroiditis. The first sister manifested late findings of multiple punched-out chorioretinal lesions and a quiescent central fibrovascular scar. The second sister presented in the acute phase with multiple creamy yellow lesions near the optic nerve and fovea and with a choroidal neovascular membrane. Both cases were unilateral.


CONCLUSIONS
Multifocal choroiditis is an inflammatory disorder of the inner choroid and retinal pigment epithelium of unknown etiology. There is no gene associated with multifocal choroiditis, and to our knowledge, no cases of relatives with the disease have been reported.


CONCLUSIONS
We describe multifocal choroiditis in two sisters, suggesting a possible genetic or environmental component to this disease. Further study is necessary to better elucidate the etiology of this disease.
From the *Department of Ophthalmology, New York University Medical Center, and †Vitreous, Retina, Macula Consultants of New York and the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York.
Jonathan P
JP
Levine
K Bailey
KB
Freund
Michael J
MJ
Cooney
James M
JM
Klancnik
Belinda L
BL
Shirkey
Lawrence A
LA
Yannuzzi