Optic neuritis as first clinical manifestations the multiple sclerosis.
OBJECTIVE
To analyze the clinical signs of multiple sclerosis (MS) and show that optic neuritis is one of the first event, which indicates the development of disease.


METHODS
The study involved 89 cases in which it confirmed MS at the time of the March 2009-2011. Since ophthalmological parameters were analyzed visual acuity (VA), visual field (VF), and retinal nerve fibre layer (RNFL) thickness of peripapillary rim by optic coherent tomography (OCT).


RESULTS
Ten(10) patients had ON as the first clinical manifestation of the disease which was statistically significant (X(2) =9,7 p=0,01) compared to the manifestation of other clinical signs of disease. In VF, centrocecal scotomas were predominant in 50% of the subjects; the RNFL thinning of the neuroretinal rim was verified in all patients, most often in the upper quadrant. A month after pulse corticosteroid therapy, visual acuity in all patients with ON ranged from 0.6 to 1.0.


CONCLUSIONS
ON is one of the first MS clinical manifestation. In VF, the most common disturbances are in the centrocecal area. The RNFL thinning was verified in all patients with OCT.
Eye Clinic, Clinical University Center Sarajevo, Bosnia and Herzegovina.
Emina Alimanovic
EA
Halilovic
Eye Clinic, Clinical University Center Sarajevo, Bosnia and Herzegovina.
Ilda
I
Alimanovic
Neurological Clinic, Clinical University Center Sarajevo, Bosnia and Herzegovina.
Enra
E
Suljic
Eye Clinic, Clinical University Center Sarajevo, Bosnia and Herzegovina.
Nabil Al
NA
Hassan
multiple sclerosis (MS); optic neuritis (ON); retinal nerve fibre layer (RNFL) thickness; visual acuity (VA); visual field (VF)