Chromatin landscape and circadian dynamics: Spatial and temporal organization of clock transcription.
Circadian rhythms drive the temporal organization of a wide variety of physiological and behavioral functions in ∼24-h cycles. This control is achieved through a complex program of gene expression. In mammals, the molecular clock machinery consists of interconnected transcriptional-translational feedback loops that ultimately ensure the proper oscillation of thousands of genes in a tissue-specific manner. To achieve circadian transcriptional control, chromatin remodelers serve the clock machinery by providing appropriate oscillations to the epigenome. Recent findings have revealed the presence of circadian interactomes, nuclear "hubs" of genome topology where coordinately expressed circadian genes physically interact in a spatial and temporal-specific manner. Thus, a circadian nuclear landscape seems to exist, whose interplay with metabolic pathways and clock regulators translates into specific transcriptional programs. Deciphering the molecular mechanisms that connect the circadian clock machinery with the nuclear landscape will reveal yet unexplored pathways that link cellular metabolism to epigenetic control.
Center for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697.
Lorena
L
Aguilar-Arnal
Center for Epigenetics and Metabolism, Unit 904 of INSERM, Department of Biological Chemistry, University of California, Irvine, CA 92697 psc@uci.edu.
Paolo
P
Sassone-Corsi
D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D057906:Circadian Clocks / Q000235:genetics / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D044127:Epigenesis, Genetic / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D008322:Mammals / Q000502:physiology*; D053858:Metabolic Networks and Pathways / Q000502:physiology; D008954:Models, Biological; D037761:Sirtuins / Q000378:metabolism; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D037761:Sirtuins
chromatin; circadian rhythms; epigenetics; nuclear organization