Biliary adenofibroma with carcinoma in situ: a rare case report.
This case report exhibits a rare biliary tumor within the liver of a 53-year-old Caucasian woman. This exophytic, multicystic, 6.5 × 5.0 cm mass was composed of complex tubulocystic structures lined by nonmucin-secreting, biliary epithelium embedded in fibrous stroma, consistent with biliary adenofibroma. This is the seventh case described in the literature. Multiple foci of high-grade dysplasia/carcinoma in situ were found with a microscopic focus of invasive carcinoma in review of the pathology, making this only the second case reporting malignant transformation. It is presented to illustrate the premalignant potential in a biliary epithelial tumor currently categorized as benign.
Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA.
N Thao T
NT
Nguyen
Department of Surgery, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA.
Theresa R
TR
Harring
Department of Pathology, St. Luke's Episcopal Hospital, 6720 Bertner Avenue, Houston, TX 77030, USA.
Laurie
L
Holley
Division of Abdominal Transplantation, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA.
John A
JA
Goss
Division of Abdominal Transplantation, Baylor College of Medicine, One Baylor Plaza, Suite 404D, Houston, TX 77030, USA.
Christine A
CA
O'Mahony