pH-stimulated DNA hydrogels exhibiting shape-memory properties.
Nucleic acid-functionalized polyacrylamide chains that are cooperatively cross-linked by i-motif and nucleic acid duplex units yield, at pH 5.0, DNA hydrogels exhibiting shape-memory properties. Separation of the i-motif units at pH 8.0 dissolves the hydrogel into a quasi-liquid phase. The residual duplex units provide, however, a memory code in the quasi-liquid allowing the regeneration of the hydrogel shape at pH 5.0.
The Institute of Chemistry, The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem, 91904, Israel.
Weiwei
W
Guo
Chun-Hua
CH
Lu
Ron
R
Orbach
Fuan
F
Wang
Xiu-Juan
XJ
Qi
Alessandro
A
Cecconello
Dror
D
Seliktar
Itamar
I
Willner
D020106:Acrylamide / Q000737:chemistry; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D012212:Rheology; D013057:Spectrum Analysis
D020100:Hydrogels; D011108:Polymers; D020106:Acrylamide; D004247:DNA
acrylamide; gel; i-motif; nucleic acid; switch