Cells producing their own nemesis: understanding methylglyoxal metabolism.
Methylglyoxal, which is technically known as 2-oxopropanal or pyruvaldehyde, shows typical reactions of carbonyl compounds as it has both an aldehyde and a ketone functional group. It is an extremely cytotoxic physiological metabolite, which is generated by both enzymatic and nonenzymatic reactions. The deleterious nature of the compound is due to its ability to glycate and crosslink macromolecules like protein and DNA, respectively. However, despite having toxic effects on cellular processes, methylglyoxal retains its efficacy as an anticancer drug. Indeed, methylglyoxal is one of the well-known anticancer therapeutic agents used in the treatment. Several studies on methylglyoxal biology revolve around the manifestations of its inhibitory effects and toxicity in microbial growth and diabetic complications, respectively. Here, we have revisited the chronology of methylglyoxal research with emphasis on metabolism of methylglyoxal and implications of methylglyoxal production or detoxification on bacterial pathogenesis and disease progression.
Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru, Karnataka, India.
Sangeeta
S
Chakraborty
Kapudeep
K
Karmakar
Dipshikha
D
Chakravortty
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy* / Q000378:metabolism; D048909:Diabetes Complications / Q000188:drug therapy* / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D011765:Pyruvaldehyde / Q000494:pharmacology*
D011765:Pyruvaldehyde; D005947:Glucose
AGEs; anti-cancer agent; bacterial pathogenesis; glyoxalase; methylglyoxal metabolism