Sulfur incorporation: copper-catalyzed cascade cyclization of 1,7-enynes with metal sulfides toward thieno[3,4-c]quinolin-4(5H)-ones.
A novel copper-catalyzed cascade cyclization of 1,7-enynes with metal sulfides is described. This sulfur-incorporation method provides straightforward access toward the important thiophene-fused quinolin-4(5H)-one scaffold through cyclization and double C-S bond formation cascade, and the chemoselectivity of this 1,7-enyne cyclization toward 1,3,3a,9b-tetrahydrothieno[3,4-c]quinolin-4(5H)-ones and 3,3a-dihydrothieno[3,4-c]quinolin-4(5H)-ones can be controlled by varying the sulfur resources.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University , Changsha 410082, China.
Yu
Y
Liu
Jia-Ling
JL
Zhang
Ren-Jie
RJ
Song
Jin-Heng
JH
Li