Mitochondrial pharmacology: its future is now.
Mitochondrial medicine is an evolving discipline whose importance derives from the central function of mitochondria in adenosine triphosphate (ATP) production, generation of reactive oxygen species, and cell death by necrosis or apoptosis. Consequently, mitochondrial dysfunction plays an important role in the progression of aging and the pathophysiology of many common diseases and off-target drug effects. This provides an impetus for the development of mitochondrial pharmacology, and some promising therapeutic targets for mitochondrial protective therapy have been identified.
Department of Pharmacology, Joan and Sanford I. Weill Medical College of Cornell University, New York, New York, USA.
H H
HH
Szeto
Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA.
L P
LP
James
Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
A J
AJ
Atkinson
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D028361:Mitochondrial Diseases / Q000188:drug therapy; D017382:Reactive Oxygen Species / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
D017382:Reactive Oxygen Species; D014451:Ubiquinone; D000255:Adenosine Triphosphate; C024989:coenzyme Q10