Associations of HLA class I alleles in Japanese patients with Crohn's disease.
Previous studies have suggested that the human leukocyte antigen (HLA) is involved in the etiology of Crohn's disease (CD); however, few reports are available on the association between HLA class I antigens and CD in Japan. In this study, we performed association analysis of HLA class I antigens in CD using 208 Japanese patients and 384 healthy controls. We identified novel positive associations between CD and HLA-A*02:01 (odds ratio (OR)=1.64, P=0.016) and HLA-A*02:07 (OR=2.31, P=0.0067) and confirmed previously reported positive associations between CD and HLA-Cw*14:02 (OR=2.18, P=0.0021) and HLA-B*51:01 (OR=1.70, P=0.033). We also identified novel negative associations between CD and HLA-A*24:02 (OR=0.60, P=0.0047) and HLA-B*07:02 (OR=0.38, P=0.0041). Although the associations were not significant after full Bonferroni correction, we suggested that HLA class I genes have dual functions, susceptibility and resistance in controlling the development of CD.
Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
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D
Oryoji
Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
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T
Hisamatsu
Department of Advanced Therapeutics for Gastrointestinal Diseases, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
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K
Tsuchiya
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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J
Umeno
Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
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S
Ueda
Department of Medical Chemistry, Kurume University School of Medicine, Fukuoka, Japan.
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K
Yamamoto
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
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T
Matsumoto
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan.
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M
Watanabe
1] Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan [2] Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Minato-ku, Tokyo, Japan.
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T
Hibi
Institute for Advanced Study, Kyushu University, Fukuoka, Japan.
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T
Sasazuki
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003424:Crohn Disease / Q000235:genetics*; D005805:Genes, MHC Class I; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007564:Japan
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens