An 8-wk, randomized, double-blind, placebo-controlled clinical trial for the antidiabetic effects of hydrolyzed ginseng extract.
BACKGROUND
To investigate the antidiabetic effects of hydrolyzed ginseng extract (HGE) for Korean participants in an 8-wk, randomized, double-blinded, placebo-controlled clinical trial.


METHODS
Impaired fasting glucose participants [fasting plasma glucose (FPG) ≥ 5.6mM or < 6.9mM] who had not been diagnosed with any disease and met the inclusion criteria were recruited for this study. The 23 participants were randomly divided into either the HGE (n = 12, 960 mg/d) or placebo (n = 11) group. Outcomes included measurements of efficacy (FPG, postprandial glucose, fasting plasma insulin, postprandial insulin, homeostatic model assessment-insulin resistance, and homeostatic model assessment-β) and safety (adverse events, laboratory tests, electrocardiogram, and vital signs).


RESULTS
After 8 wk of HGE supplementation, FPG and postprandial glucose were significantly decreased in the HGE group compared to the placebo group. No clinically significant changes in any safety parameter were observed. Our study revealed that HGE is a potent antidiabetic agent that does not produce noticeable adverse effects.


CONCLUSIONS
HGE supplementation may be effective for treating impaired fasting glucose individuals.
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Soo-Hyun
SH
Park
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Mi-Ra
MR
Oh
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Eun-Kyung
EK
Choi
Clinical Trial Center, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Min-Gul
MG
Kim
Healthcare Claims and Management Incorporation, 758 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Ki-Chan
KC
Ha
Central Research Center, Ilhwa Co., Ltd., 25, Angol-ro, 56Beon-gil, Guri, Gyeonggi, Korea.
Seung-Kwon
SK
Lee
Department of Urology, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Young-Gon
YG
Kim
Department of Biochemistry, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Byung-Hyun
BH
Park
Department of Laboratory Medicine, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Dal-Sik
DS
Kim
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea ; Clinical Trial Center, Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju, Jeonbuk, Korea ; Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk, Korea.
Soo-Wan
SW
Chae
Panax ginseng; clinical trial; hydrolyzed ginseng extract; impaired fasting glucose; oral glucose tolerance test