[Implementation of scanning probe microscopy for the solution of molecular diagnostics tasks].
We present new approaches to improve the efficiency of DNA by scanning probe microscopy using a highly specific hybridization on affine surfaces and nanostructures of gold as a labels. Scanning probe microscopy allows to register of individual acts of hybridization by the detection of gold labels on the surface affinity followed by automatic calculation of the total.
E V
EV
Dubrovin
G V
GV
Presnova
M Yu
MY
Rubtsova
V G
VG
Grigorenko
A I
AI
Ivanin
A M
AM
Egorov
I V
IV
Yaminsky
D004269:DNA, Bacterial / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D020527:Microscopy, Scanning Probe / Q000379:methods*; D009693:Nucleic Acid Hybridization / Q000379:methods; D009841:Oligonucleotides / Q000737:chemistry; D057089:Pathology, Molecular / Q000379:methods*
D004269:DNA, Bacterial; D009841:Oligonucleotides; D006046:Gold
DNA-biosensor; analysis and image processing; highly specific hybridization; nanoparticles; scanning probe microscopy