Bioactive natural products from fungicolous Hawaiian isolates: secondary metabolites from aPhialemoniopsissp.
Chemical investigations of two fungal isolates initially identified as members of the genusPhialemoniumare described. Both isolates were obtained as colonists of other fungi collected on the island of Hawaii and were later assigned asP. curvatum. However,P. curvatumhas recently been reclassified as a member of a new genus (Phialemoniopsis) and renamed asPhialemoniopsis curvata. Studies of solid-substrate fermentation cultures of one of these isolates afforded an oxirapentyn analogue and destruxin A4as major components, while analysis of the second strain led to the isolation of several simple aromatic metabolites and a compound of mixed biogenetic origin called gabusectin that had previously been reported only in a patent. Structures were assigned mainly by detailed nuclear magnetic resonance and mass spectrometry analysis, and those of two of the major components were confirmed by X-ray crystallography. This report constitutes the first description of secondary metabolites from a member of the genusPhialemoniopsis.
Department of Chemistry, University of Iowa , Iowa City , IA 52242 , USA.
Amninder
A
Kaur
Department of Chemistry, University of Iowa , Iowa City , IA 52242 , USA.
Kristina D
KD
Rogers
Department of Chemistry, University of Iowa , Iowa City , IA 52242 , USA.
Dale E
DE
Swenson
Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA , Peoria , IL 61604 , USA.
Patrick F
PF
Dowd
Bacterial Foodborne Pathogens & Mycology Research Unit, Agricultural Research Service, National Center for Agricultural Utilization Research, USDA , Peoria , IL 61604 , USA.
Donald T
DT
Wicklow
Department of Chemistry, University of Iowa , Iowa City , IA 52242 , USA.
James B
JB
Gloer
Phialemoniopsis curvata; Phialemonium; destruxin; gabusectin; oxirapentyn