Comparing different imaging modalities in harada disease: a case report.
OBJECTIVE
The purpose of this study was to compare fluorescein angiography, infrared imaging, fundus autofluorescence, and optical coherent tomography for the diagnosing and monitoring of Harada disease.


METHODS
This was an interventional case report.


RESULTS
A 46-year-old Chinese woman presented with headache, tinnitus, and diminished vision in both eyes. Examination revealed bilateral exudative retinal detachment. Optical coherence tomography showed fluid accumulation in three different layers (intraretinal, subretinal, and subretinal pigment epithelium). Fundus autofluorescence revealed regions of hypoautofluorescence as a result of the thick fluid accumulation. Infrared imaging revealed more clinically relevant information than did fundus autofluorescence in this case.


CONCLUSIONS
In Harada disease, excessive fluid accumulates in three different layers. Optical coherence tomography is the most effective modality in measuring the axial distribution of the fluid in the z-plane, whereas infrared imaging is better at providing the information in the x-y plane, compared with fundus autofluorescence.
From the *Department of Pathology, Bernard and Shirlee Brown Glaucoma Laboratory, Edward S. Harkness Eye Institute, New York, New York; †Department of Ophthalmology, Chang Gung Memorial Hospital, Linkon, Taiwan; and ‡Chang Gung University College of Medicine, Tao-Yuan, Taiwan.
Nan-Kai
NK
Wang
Chai Lin
CL
Chou
Stephen H
SH
Tsang