Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome.
Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy.
Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Via Tronto 10, 60126 Ancona, Italy.
Maria Giovanna
MG
Danieli
U.O. di Medicina-LPA, Presidio di Loreto, 66025 Loreto, Italy.
Lucia
L
Pettinari
Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Via Tronto 10, 60126 Ancona, Italy.
Ramona
R
Morariu
U.O. di Radiodiagnostica, Ospedale di Casarano, 73042 Lecce, Italy.
Fernando
F
Monteforte
Clinica Neurologica, Dipartimento di Medicina Sperimentale e Clinica, Polo Didattico Scientifico, Università Politecnica delle Marche & Azienda Ospedali Riuniti, Via Tronto 10, 60126 Ancona, Italy.
Francesco
F
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