Distinct composition of the oral indigenous microbiota in South Korean and Japanese adults.
A comparison of national surveys on oral health suggested that the population of South Korea has a better periodontal health status than that of Japan, despite their similar inherent backgrounds. Here, we investigated differences in oral bacterial assemblages between individuals from those two countries. To exclude potential effects of oral health condition on the microbiota, we selected 52 Korean and 88 Japanese orally healthy adults (aged 40-79 years) from the participants of two cohort studies, the Yangpyeong study in South Korea and the Hisayama study in Japan, and compared the salivary microbiomes. The microbiota of the Japanese individuals comprised a more diverse community, with greater proportions of 17 bacterial genera, including Veillonella, Prevotella, and Fusobacterium, compared to the microbiota of the Korean individuals. Conversely, Neisseria and Haemophilus species were present in much lower proportions in the microbiota of the Japanese individuals than the Korean individuals. Because higher proportions of Prevotella and Veillonella and lower proportions of Neisseria and Haemophilus in the salivary microbiome were implicated in periodontitis, the results of this study suggest that the greater proportion of dysbiotic oral microbiota in the Japanese individuals is associated with their higher susceptibility to periodontitis compared to the Korean individuals.
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Toru
T
Takeshita
1] Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan [2] Section of Dental Anesthesiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Kazuki
K
Matsuo
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Michiko
M
Furuta
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Yukie
Y
Shibata
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Kaoru
K
Fukami
Department of Preventive Dentistry and Dental Public Health, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Yoshihiro
Y
Shimazaki
Department of Oral Health Management, School of Oral Health Science, Kyushu Dental University, Kitakyushu, Japan.
Sumio
S
Akifusa
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
Dong-Hung
DH
Han
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, Seoul, Korea.
Hyun-Duck
HD
Kim
Section of Dental Anesthesiology, Division of Maxillofacial Diagnostic and Surgical Sciences, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Takeshi
T
Yokoyama
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiharu
T
Ninomiya
Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yutaka
Y
Kiyohara
Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Kyushu University Faculty of Dental Science, Fukuoka, Japan.
Yoshihisa
Y
Yamashita
D000328:Adult; D000368:Aged; D004269:DNA, Bacterial / Q000235:genetics*; D005260:Female; D005673:Fusobacterium / Q000235:genetics / Q000302:isolation & purification; D006190:Haemophilus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D054892:Metagenome; D064307:Microbiota / Q000235:genetics*; D008875:Middle Aged; D009055:Mouth / Q000382:microbiology*; D009343:Neisseria / Q000235:genetics / Q000302:isolation & purification; D009909:Oral Health / Q000208:ethnology; D009910:Oral Hygiene; D010518:Periodontitis / Q000453:epidemiology / Q000208:ethnology; D018720:Prevotella / Q000235:genetics / Q000302:isolation & purification; D012336:RNA, Ribosomal, 16S / Q000235:genetics*; D056910:Republic of Korea / Q000453:epidemiology; D012463:Saliva / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D014678:Veillonella / Q000235:genetics / Q000302:isolation & purification
D004269:DNA, Bacterial; D012336:RNA, Ribosomal, 16S