Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease.
Two fluorescent switchable diarylethene derivatives which exhibit high affinity for amyloid-β aggregates with the increase of fluorescence intensity were reported. Moreover, the probes show excellent photochromic and anti-photobleaching properties both in vitro and in vivo.
Department of Chemistry & Innovation Center of Chemistry for Energy Materials, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China. yitao@fudan.edu.cn.
Guanglei
G
Lv
Baiping
B
Cui
Haichuang
H
Lan
Ying
Y
Wen
Anyang
A
Sun
Tao
T
Yi
D000544:Alzheimer Disease / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000032:analysis*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003474:Curcumin / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008856:Microscopy, Fluorescence
D016229:Amyloid beta-Peptides; D005456:Fluorescent Dyes; D003474:Curcumin