Multifunctional "smart" particles engineered from live immunocytes: toward capture and release of cancer cells.
Multifunctional "smart" particles with magnetic, topographic, cell-targeting, and stimulus-responsive properties are obtained using a "live template" strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enable the release of captured cells with high viability via reduction of disulfide bonds. Diverse multifunctional particles can be designed using the "live template" strategy.
Laboratory of Bio-inspired Smart Interface Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P.R. China.
Chao
C
Huang
Gao
G
Yang
Qing
Q
Ha
Jinxin
J
Meng
Shutao
S
Wang
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry*; D001773:Blood Cells / Q000502:physiology; D060846:Cell Engineering / Q000295:instrumentation* / Q000379:methods; D002470:Cell Survival; D004705:Endocytosis; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D061986:MCF-7 Cells; D008264:Macrophages / Q000502:physiology*; D058185:Magnetite Nanoparticles; D009369:Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D010587:Phagocytosis / Q000502:physiology; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry
D058185:Magnetite Nanoparticles; D012822:Silicon Dioxide
cell capture; cell release; topographic structures; “live template”; “smart” particles