Elective orthopedic and cardiopulmonary bypass surgery causes a reduction in serum endostatin levels.
BACKGROUND
Endostatin is an endogenous inhibitor of angiogenesis that inhibits neovascularisation. The aim of the study was to evaluate the effect of elective surgery on endostatin levels.


METHODS
Blood samples were collected prior to elective surgery and 4 and 30 days postoperatively in 2 patient groups: orthopedic surgery (n =27) and coronary bypass patients (n =21). Serum endostatin levels were measured by ELISA.


RESULTS
Serum endostatin was significantly reduced 30 days after surgery in comparison with presurgical values in both the orthopedic (P =0.03) and cardiopulmonary surgery (P =0.04) group.


CONCLUSIONS
Serum endostatin is reduced 30 days after surgery. This reduction would favor angiogenesis and wound-healing.
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. torbjorn.akerfeldt@akademiska.se.
Torbjörn
T
Åkerfeldt
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. lena.gunningberg@pubcare.uu.se.
Lena
L
Gunningberg
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. Christine.Leo.Swenne@pubcare.uu.se.
Christine Leo
CL
Swenne
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. goran.ronquist@medsci.uu.se.
Göran
G
Ronquist
Department of Medical Sciences, Section of Clinical Chemistry, Uppsala University, Uppsala, Sweden. anders.larsson@akademiska.se.
Anders
A
Larsson
D000368:Aged; D000369:Aged, 80 and over; D002315:Cardiopulmonary Bypass / Q000379:methods; D001026:Coronary Artery Bypass / Q000379:methods; D043169:Endostatins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures; D011183:Postoperative Complications / Q000517:prevention & control; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*
D043169:Endostatins