Demographics, clinical features, outcome and prognostic factors of Guillain-Barre syndrome in Thai children.
OBJECTIVE
To describe demographics, clinical profiles, management, outcomes and to determine factors associated with severity in Guillain-Barre Syndrome (GBS).


METHODS
Medical records of GBS patients in Queen Sirikit National Institute of Child Health during 2000-2009 were searched. The data included demographics, clinical features, management and outcomes after 6 months to determine prognostic factors.


RESULTS
Forty-eight patients with GBS were studies. Mean age of onset was 5 years. Male and female ratio was 1.4:1. History of antecedent infection was 73%. Clinical presentations included limb weakness 100%, respiratory distress 27%, facial palsy 27%, autonomic nervous dysfunction 22% and ataxia 17%. Nerve conduction study revealed demyelinating process in 57%, axonopathy in 26% and mixed type in 17%. Clinical outcomes were satisfactory in most of the patients except three patients who still had disability eighteen months after onset. Autonomic nervous dysfunction was a significant factor to determine the severity.


CONCLUSIONS
The demographic and clinical features of GBS were similar to other published studies. The autonomic nervous dysfunction was a significant predictor for adverse clinical course. All but three patients had complete, full recovery.
Somjit
S
Sri-udomkajorn
Sirorat
S
Suwannachote
D000293:Adolescent; D001341:Autonomic Nervous System / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000453:epidemiology* / Q000208:ethnology / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D018908:Muscle Weakness / Q000150:complications; D009460:Neurologic Examination; D010291:Paresis; D011379:Prognosis; D012189:Retrospective Studies; D013785:Thailand; D016896:Treatment Outcome