Replication study of previous migraine genome-wide association study findings in a Spanish sample of migraine with aura.
BACKGROUND
Migraine is a common disabling condition that affects approximately 15% of the population. Several genome-wide association studies have attempted to identify susceptibility variants involved in migraine, reporting several candidate loci for the disorder.


METHODS
In order to replicate findings from previous genome-wide association studies, a case-control association study was performed. Twelve single nucleotide polymorphisms were genotyped in a Spanish sample of 512 migraine with aura patients and 535 migraine-free controls.


RESULTS
Nominal associations were found for single nucleotide polymorphisms rs2651899 (within the PRDM16 gene), rs10166942 (near TRPM8), rs12134493 (close to TSPAN2) and rs10504861 (near MMP16) in our migraine with aura sample.


CONCLUSIONS
Our study provides suggestive replication, in a Spanish migraine with aura sample, of four genome-wide association study findings previously reported in common migraine. However, larger sample sets should be explored to confirm our results.
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain Center for Biomedical Network Research on Rare Diseases (CIBERER)-Institute of Health Carlos III, Spain.
Cèlia
C
Sintas
Headache and Neurological Pain Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Spain.
Jèssica
J
Fernández-Morales
Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain.
Marta
M
Vila-Pueyo
Neurology Service, Hospital Sant Joan de Déu (Fundació Althaia), Spain.
Bernat
B
Narberhaus
Department of Statistics, University of Barcelona, Spain.
Concepció
C
Arenas
Headache and Neurological Pain Laboratory, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain Headache Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Spain.
Patricia
P
Pozo-Rosich
Pediatric Neurology Research Group, Vall d'Hebron Research Institute, Universitat Autònoma de Barcelona, Spain.
Alfons
A
Macaya
Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, Spain Institut de Biomedicina de la Universitat de Barcelona (IBUB), Spain Center for Biomedical Network Research on Rare Diseases (CIBERER)-Institute of Health Carlos III, Spain bcormand@ub.edu.
Bru
B
Cormand
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020325:Migraine with Aura / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013030:Spain; D044465:White People / Q000235:genetics
MMP16; Migraine with aura; PRDM16; TRPM8; TSPAN2; association study