Remedial applications of silencing ribonucleic acids and modalities for its delivery to the kidneys--a review.
BACKGROUND
The Kidney has been the target organ for the delivery of silencing ribonucleic acids (silencing RNA) administered systemically in comparison to other body tissues.


METHODS
In this review, we discussed different approaches made to delivering proteins to the kidneys in different conditions like normal and pathological defects. Data from clinical experiments have been used to discuss and support the administration of silencing RNA for the treatment of kidney diseases.


RESULTS
Results were achieved using the available genome wide RNA libraries.


CONCLUSIONS
The research results are helpful in application to 3D and conventional models to find the involvement of signal pathways in kidney diseases.
Medical Education Center, Langfang Health Vocational College, 065001. Langfang, Heibei Province, China.
Dongjie
D
Wang
Children Health Department, Langfang Women and Children's Health Center, 065000, Langfang, Heibei Province, China.
Yanfen
Y
Lv
Obstetrics and Gynecology Education Center, Langfang Health Vocational College, 065001, Langfang, Heibei Province, China.
Huifang
H
Zhu
Traditional Chinese Medicine Education Center, Langfang Health Vocational College, 065001, Langfang, Heibei Province, China.
Guifeng
G
Lv
Nephrology Department, The First Affiliated Hospital of Xiamen University, Tongmin Branch Court, 361000, Xiamen, Fujian Province, China.
Jiyi
J
Huang
D015316:Genetic Therapy; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy; D011506:Proteins / Q000378:metabolism*; D012313:RNA; D034622:RNA Interference
D011506:Proteins; D012313:RNA
kidney disease; signal pathways; silencing RNA; targeting proteins