Generalized mid dermal elastolysis.
Mid-dermal elastolysis (MDE) is a rare skin disorder clinically characterized by the appearance of diffuse fine wrinkling, most often of the trunk and arms. This entity is distinguished from other elastolytic disorders by its characteristic selective loss of elastic fibers of the mid dermis. The aetiopathogenesis of the disease is still unclear as well as the effective treatment. Half of the cases described in the literature are associated with ultraviolet radiation exposure. Other reported triggering conditions such as urticaria, eczema and granuloma annulare suggests different eliciting inflammatory pathways. The authors describe the case of a 38-year-old woman who developed an urticarial eruption during months which progressed to generalized and severe fine wrinkling.
Department of Dermatology and Venereology, Hospital de São João, E.P.E. Porto, Portugal.
Maria João
MJ
Cruz
Department of Dermatology and Venereology, Hospital de São João, E.P.E. Porto, Portugal.
Ana Margarida
AM
Barros
Department of Dermatology and Venereology, Hospital de São João, E.P.E. Porto, Portugal.
Filomena
F
Azevedo
disorders of elactic fibers; elastophagocytosis.; mid dermal elastolysis