Neuroglobin - recent developments.
Neuroglobin (Ngb), a monomeric hexacoordinated heme protein of 17 kDa, was identified in 2000 in the nervous system. Accumulative evidence has proved that Ngb is an endogenous neuroprotective molecule against ischemic/hypoxic insults and oxidative stresses, and in most ischemic conditions, Ngb is up-regulated. The underlying mechanisms, however, are not fully clarified. Here we review the recent experimental findings, mainly focusing on the mechanisms of Ngb's protection and induction during ischemic/hypoxic conditions, the roles of Ngb in astrocytes and tumors, as well as Ngb's function in neurite outgrowth.
Xin Yao
XY
Qiu
Xiao Qian
XQ
Chen
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D015687:Cell Hypoxia; D005786:Gene Expression Regulation; D005914:Globins / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016501:Neurites / Q000378:metabolism*; D000078787:Neuroglobin; D018384:Oxidative Stress
D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D005914:Globins