A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.
The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.
Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.
Yinsheng
0000-0002-3629-0076
Y
Wang
Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.
Lidan
L
Zha
Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.
Dan
D
Liao
Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.
Xiaozhi
X
Li