[Change and significance of blood lipids during the course of carotid artery plaque formation induced by diabetes mellitus in patients with ischemic cerebral vascular disease].
OBJECTIVE
To explore the change and possible role of blood lipids during the course of plaque formation induced by diabetes mellitus in patients with ischemic cerebral vascular disease.


METHODS
A total of 1 464 hospitalized patients with a diagnosis of ischemic cerebral vascular disease at our department from February 2008 to May 2012. They were distinguished as plaque (n = 332) or not (n = 132) based on carotid artery intima-media thickness (IMT) on B-mode ultrasound. And there were diabetics (n = 153) and non-diabetics (n = 311). Also blood glucose, blood lipids and new infarction or not were recorded. Comparisons of positive carotid artery plaque and the level of blood glucose and lipids were made between diabetics and non-diabetics. And the level-risk relationship between plaque formation and diabetes mellitus or blood lipids were performed through Logistic regression.


RESULTS
The positive rate of carotid artery plaque was higher in diabetics versus non-diabetics (80% vs 67%, P = 0.003), OR (95% CI, P value) was 2.001 (1.258-3.182, 0.001) through Logistic regression; after adjusting for cerebral infarction, 1.875 (1.172-3.000, 0.009). It had a lower level of high-density lipoprotein-cholesterol (HDL-C) in diabetics versus non-diabetics (1.1 ± 0.3 vs 1.2 ± 0.3 mmol/L, P = 0.001). HDL-C was correlated with plaque formation while OR (95% CI, P value) was 0.416 (0.210-0.823, 0.012) through Logistic regression. And there has no correlation between plaque formation and other subtypes of blood lipids.


CONCLUSIONS
A decrease of HDL-C may play an important role in the course of carotid artery plaque induced by diabetes mellitus in patients with ischemic cerebral vascular disease.
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China. Email: njluoyun@sina.com.
Yun
Y
Luo
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Jingwei
J
Li
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Dening
D
Guan
Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
Yun
Y
Xu
D001786:Blood Glucose; D002340:Carotid Artery Diseases / Q000097:blood* / Q000209:etiology; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000097:blood* / Q000209:etiology; D008076:Cholesterol, HDL; D048909:Diabetes Complications; D006801:Humans; D008055:Lipids / Q000097:blood*; D016015:Logistic Models; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000209:etiology; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000150:complications
D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids