Successful thrombolytic treatment of neonatal arterial thromboses.
Compared to children of other age groups neonates show an increased thrombotic risk. The acute therapy depends on thrombus age, the localisation of vascular occlusion and the severity of the underlying disease. The treatment of choice is represented by the administration of unfractionated (UFH) or low molecular weight heparin (LMWH). If loss of limbs or organs is imminent, the application of thrombolytic treatment with recombinant tissue-type plasminogen activator (rt-PA) should be considered whilst taking into account the associated bleeding risk. We report on two patients in which thrombolytic therapy has been conducted successfully.
Julia Stächele, Klinik und Poliklinik für Kinder- und Jugendmedizin, Fachbereich Hämostaseologie, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany, E-Mail: Julia.Staechele@uniklinikum-dresden.de.
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Stächele
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Dinger
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Brenner
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Hofmann
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Ifflaender
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Knöfler
D000925:Anticoagulants / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000188:drug therapy; D007234:Infant, Premature; D008297:Male; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000175:diagnosis* / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D016896:Treatment Outcome
D000925:Anticoagulants; D006493:Heparin; D010959:Tissue Plasminogen Activator
Neonates; thrombolytic therapy; thrombosis