A new prenylated indole diketopiperazine alkaloid from Eurotium cristatum.
A new prenylated indole diketopiperazine alkaloid, cristatumin F (1), and four known metabolites, echinulin (2), dehydroechinulin (3), neoechinulin A (4) and variecolorin O (5), were isolated from the crude extract of the fungus Eurotium cristatum. The structure of 1 was elucidated primarily by NMR and MS methods. The absolute configuration of 1 was assigned using Marfey's method applied to its acid hydrolyzate. Cristatumin F (1) showed modest radical scavenging activity against DPPH radicals, and exhibited marginal attenuation of 3T3L1 pre-adipocytes.
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. zouxw000@126.com.
Xianwei
X
Zou
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. liying_90126@126.com.
Ying
Y
Li
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. zouxw000@126.com.
Xiaona
X
Zhang
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. yaoyaoldlq@163.com.
Qian
Q
Li
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. liux_54@163.com.
Xuan
X
Liu
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. sungood591@sina.com.
Yun
Y
Huang
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. tao_tang1@126.com.
Tao
T
Tang
Shanghai Tobacco Group Corporation, Shanghai 200082, China. zhengsj@sh.tobacco.com.cn.
Saijing
S
Zheng
Shanghai Tobacco Group Corporation, Shanghai 200082, China. zdsys@sh.tobacco.com.cn.
Weimiao
W
Wang
Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China. tangjt@mail.tsinghua.edu.cn.
Jintian
J
Tang
D016475:3T3 Cells; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D054659:Diketopiperazines / Q000737:chemistry* / Q000302:isolation & purification*; D055325:Eurotium / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice
D000470:Alkaloids; D054659:Diketopiperazines; D016166:Free Radical Scavengers; D007211:Indoles; C030374:indole