Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy.
Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50 °C under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1-5 W/cm(2)). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinoma in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Konstantin P
KP
Tamarov
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Liubov A
LA
Osminkina
Blokhin Russian Cancer Research Center, 115478 Moscow, Russia.
Sergey V
SV
Zinovyev
Aix Marseille University, CNRS, LP3 UMR 7341, Campus de Luminy - Case 917, 13288, Marseille Cedex 9, France.
Ksenia A
KA
Maximova
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Julia V
JV
Kargina
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Maxim B
MB
Gongalsky
Aix Marseille University, CNRS, LP3 UMR 7341, Campus de Luminy - Case 917, 13288, Marseille Cedex 9, France.
Yury
Y
Ryabchikov
Aix Marseille University, CNRS, LP3 UMR 7341, Campus de Luminy - Case 917, 13288, Marseille Cedex 9, France.
Ahmed
A
Al-Kattan
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Andrey P
AP
Sviridov
Aix Marseille University, CNRS, LP3 UMR 7341, Campus de Luminy - Case 917, 13288, Marseille Cedex 9, France.
Marc
M
Sentis
Blokhin Russian Cancer Research Center, 115478 Moscow, Russia.
Andrey V
AV
Ivanov
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Vladimir N
VN
Nikiforov
Aix Marseille University, CNRS, LP3 UMR 7341, Campus de Luminy - Case 917, 13288, Marseille Cedex 9, France.
Andrei V
AV
Kabashin
Lomonosov Moscow State University, Department of Physics, 119991 Moscow, Russia.
Victor Yu
VY
Timoshenko
D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000473:pathology / Q000628:therapy*; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D003460:Crystallization; D006614:Hindlimb; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D015552:Injections, Intralesional; D007834:Lasers; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009368:Neoplasm Transplantation; D016062:Porosity; D012825:Silicon / Q000737:chemistry*; D013696:Temperature
D012825:Silicon