Comparison of pulmonary involvement between patients expressing anti-PL-7 and anti-Jo-1 antibodies.
Anti-PL-7 is an anti-tRNA synthetase antibody, and interstitial lung disease (ILD) is the most frequent complication of anti-PL-7-associated antisynthetase syndrome. However, the features of ILD have not been fully elucidated. The present study retrospectively compares 7 and 15 patients who were positive for anti-PL-7 and anti-Jo-1 antibodies, respectively. The features of ILD did not significantly differ between the two groups, but the ratio of lymphocytes in bronchoalveolar lavage fluid was higher in the Jo-1 than in the PL-7 group. High-resolution computed tomography revealed nonspecific interstitial pneumonia in all patients in the PL-7 group and organizing pneumonia in four of the 15 patients in the Jo-1 group. These findings suggest that pulmonary complications slightly differ between patients expressing anti-PL-7 and anti-Jo-1 antibodies. Further studies are required to clarify the features of ILD associated with PL-7.
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Masaomi
M
Tomonaga
Noriho
N
Sakamoto
Yuji
Y
Ishimatsu
Tomoyuki
T
Kakugawa
Tatsuhiko
T
Harada
Shota
S
Nakashima
Atsuko
A
Hara
Shintaro
S
Hara
Yoshihiro
Y
Horai
Atsushi
A
Kawakami
Hiroshi
H
Mukae
Shigeru
S
Kohno
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D018549:Cryptogenic Organizing Pneumonia / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013914:Threonine-tRNA Ligase / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D000974:Antibodies, Antinuclear; D015415:Biomarkers; C046750:Jo-1 antibody; D013914:Threonine-tRNA Ligase