LncRNA2Target: a database for differentially expressed genes after lncRNA knockdown or overexpression.
Long non-coding RNAs (lncRNAs) have emerged as critical regulators of genes at epigenetic, transcriptional and post-transcriptional levels, yet what genes are regulated by a specific lncRNA remains to be characterized. To assess the effects of the lncRNA on gene expression, an increasing number of researchers profiled the genome-wide or individual gene expression level change after knocking down or overexpressing the lncRNA. Herein, we describe a curated database named LncRNA2Target, which stores lncRNA-to-target genes and is publicly accessible at http://www.lncrna2target.org. A gene was considered as a target of a lncRNA if it is differentially expressed after the lncRNA knockdown or overexpression. LncRNA2Target provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene. Both search types are performed either by browsing a provided catalog of lncRNA names or by inserting lncRNA/target gene IDs/names in a search box.
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Qinghua
Q
Jiang
School of Software, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Jixuan
J
Wang
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Xiaoliang
X
Wu
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Rui
R
Ma
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Tianjiao
T
Zhang
Department of Mathematics, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Shuilin
S
Jin
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Zhijie
Z
Han
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Renjie
R
Tan
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Jiajie
J
Peng
Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Guiyou
G
Liu
School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China.
Yu
Y
Li
School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang 150001, China ydwang@hit.edu.cn.
Yadong
Y
Wang
D030561:Databases, Nucleic Acid; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques; D020407:Internet; D062085:RNA, Long Noncoding / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D062085:RNA, Long Noncoding