90d Exposure to Nonylphenol has Adverse Effects on the Spermatogenesis and Sperm Maturation of Adult Male Rats.
This study was conducted to elucidate the reproductive effect of NP on testis, epididymis and epididymal sperm in vivo. Adult male Sprague-Dawley rats were gavaged with NP at 0, 40, 100, or 250 mg/kg body weight (bw) on alternate days for 90 d. The results showed that oral administration of NP may damage the structure and function of testis, induce apoptosis and oxidative stress in epididymis or even have cytotoxic effects on epididymal sperm.
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; KunShan Health Inspection Station, 458 Tongfeng Road, Kunshan 215301, Jiangsu, China.
Wei Chen
WC
Lu
Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
Ai Qing
AQ
Wang
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China; The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, Xinjiang, China.
Xiao Ling
XL
Chen
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Guo
G
Yang
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Yao
Y
Lin
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Yi Ou
YO
Chen
Experimental Center of Medical College, Soochow University, Suzhou 215123, Jiangsu, China.
Cheng Jiao
CJ
Hong
Department of Occupational and Environmental Health, School of Public Health, Soochow University, Suzhou 215123, Jiangsu, China.
Hai Lin
HL
Tian
D000284:Administration, Oral; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000009:adverse effects*; D017207:Rats, Sprague-Dawley; D013081:Sperm Motility / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood
D010636:Phenols; D013739:Testosterone; C025256:nonylphenol