Glial cell development and function in zebrafish.
The zebrafish is a premier vertebrate model system that offers many experimental advantages for in vivo imaging and genetic studies. This review provides an overview of glial cell types in the central and peripheral nervous system of zebrafish. We highlight some recent work that exploited the strengths of the zebrafish system to increase the understanding of the role of Gpr126 in Schwann cell myelination and illuminate the mechanisms controlling oligodendrocyte development and myelination. We also summarize similarities and differences between zebrafish radial glia and mammalian astrocytes and consider the possibility that their distinct characteristics may represent extremes in a continuum of cell identity. Finally, we focus on the emergence of zebrafish as a model for elucidating the development and function of microglia. These recent studies have highlighted the power of the zebrafish system for analyzing important aspects of glial development and function.
Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.
David A
DA
Lyons
Department of Developmental Biology, Stanford University, Stanford, California 94305.
William S
WS
Talbot
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000502:physiology; D002454:Cell Differentiation; D019070:Cell Lineage; D008322:Mammals; D009186:Myelin Sheath / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology / Q000502:physiology*; D009836:Oligodendroglia / Q000166:cytology / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D012583:Schwann Cells / Q000378:metabolism; D015027:Zebrafish / Q000254:growth & development*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D029961:Zebrafish Proteins; C543742:stx7l protein, zebrafish