Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants.
Iron-bioceramic composites have been developed as biodegradable implant materials with tailored degradation behavior and bioactive features. In the current work, in vivo bioactivity of the composites was comprehensively studied by using sheep animal model. Five groups of specimens (Fe-HA, Fe-TCP, Fe-BCP composites, and pure-Fe and SS316L as controls) were surgically implanted into medio proximal region of the radial bones. Real-time ultrasound analysis showed a decreased echo pattern at the peri-implant biodegradation site of the composites indicating minimal tissue response during the wound healing process. Peripheral whole blood biomarkers monitoring showed a normal dynamic change of blood cellular responses and no stress effect was observed. Meanwhile, the released Fe ion concentration was increasing along the implantation period. Histological analysis showed that the composites corresponded with a lower inflammatory giant cell count than that of SS316L. Analysis of the retrieved implants showed a thicker degradation layer on the composites compared with pure-Fe. It can be concluded that the iron-bioceramic composites are bioactive and induce a preferable wound healing process.
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.|Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.
Mokhamad F
MF
Ulum
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.|Faculty of Engineering, Muhammadiyah University of Riau, Riau, Indonesia.
Ahmad K
AK
Nasution
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.
Abdul H
AH
Yusop
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.
Andril
A
Arafat
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.
Mohammed Rafiq A
MR
Kadir
Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.
Vetnizah
V
Juniantito
Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia.
Deni
D
Noviana
Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru, Malaysia.|Department of Mining, Metallurgical and Materials Engineering and CHU de Québec Research Center, Laval University, Quebec City, Canada.
Hendra
H
Hermawan
D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D002516:Ceramics / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D007501:Iron / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D008297:Male; D008422:Materials Testing; D012756:Sheep
D018786:Bone Substitutes; D007501:Iron
bioactive; bioceramics; biodegradable metals; composites; in vivo