Third- and further-line therapy in advanced non-small-cell lung cancer patients: an overview.
Non-small-cell lung cancer (NSCLC) treatment has led to improved efficacy and compliance due to individual tailoring of the therapeutic options and the use of strategies based on both clinical characteristics and histological and biological features of the disease. In nonsquamous NSCLC, novel agents, such as pemetrexed and bevacizumab, have improved survival in the first-line setting. Maintenance therapy with pemetrexed and erlotinib resulted in improved progression-free survival compared with second-line therapy at disease progression. In the second-line setting, pemetrexed improves survival in nonsquamous NSCLC compared with docetaxel, and erlotinib has shown a survival benefit compared with best supportive care in patients who did not previously receive an EGF receptor inhibitor. Although the benefit of first- and second-line treatment over best supportive care alone has been firmly established, the role of further-line treatment remains controversial. This article summarizes the state-of-the-art treatments in this setting.
Department of Medical Oncology, Bellaria Hospital - IRCCS Institute of Neurological Sciences, Azienda USL, Via Altura 3, 47841 Bologna, Italy. ggenestreti@libero.it
Giovenzio
G
Genestreti
Francesco
F
Grossi
Carlo
C
Genova
Marco A
MA
Burgio
Alberto
A
Bongiovanni
Giampaolo
G
Gavelli
Marco
M
Bartolotti
Monica
M
Di Battista
Giovanna
G
Cavallo
Alba A
AA
Brandes
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D058990:Molecular Targeted Therapy; D009367:Neoplasm Staging; D019233:Retreatment; D016896:Treatment Outcome
chemotherapy; non-small-cell lung cancer; targeted therapy; third-line therapy