The beneficial properties of marine polysaccharides in alleviation of allergic responses.
Marine polysaccharides have been found as the principle component in cell wall structures of seaweeds or exoskeletons of crustaceans. Due to numerous pharmaceutical properties of marine polysaccharides such as antioxidant, anti-inflammatory, antiallergic, antitumor, antiobesity, antidiabetes, anticoagulant, antiviral, immunomodulatory, cardioprotective, and antihepatopathy activities, they have been applied in many fields of biomaterials, food, cosmetic, and pharmacology. Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation. This contribution, therefore, focuses on antiallergic properties of marine polysaccharides and emphasizes their potential application as bioactive food ingredients as well as nutraceuticals for prevention of allergic disorders.
Marine Bioprocess Research Center, Pukyong National University, Busan, Republic of Korea.
Thanh-Sang
TS
Vo
Dai-Hung
DH
Ngo
Kyong-Hwa
KH
Kang
Won-Kyo
WK
Jung
Se-Kwon
SK
Kim
D000464:Alginates / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry / Q000494:pharmacology; D019587:Dietary Supplements; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D006967:Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D009844:Oligosaccharides; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology*; D012624:Seaweed / Q000737:chemistry*; D012685:Sepharose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D058408:Th1-Th2 Balance
D000464:Alginates; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D000998:Antiviral Agents; D006603:Hexuronic Acids; D009844:Oligosaccharides; D011134:Polysaccharides; C493484:oligochitosan; C038549:porphyran; D002686:Chitin; D007073:Immunoglobulin E; D020723:Glucuronic Acid; D012685:Sepharose; D048271:Chitosan; C007789:fucoidan
Allergic reaction; Chitin; Fucoidans; Marine polysaccharides; Th1 cells; Th2 cells