Reaching a consensus on the mechanism of dynamin?
AMONG THE PROTEINS INVOLVED IN LIPID MEMBRANE REMODELING IN INTRACELLULAR TRAFFIC, DYNAMIN HAS BEEN THE FOCUS OF MANY STUDIES, AS IT WAS THE FIRST PROTEIN SHOWN TO BE MECHANISTICALLY INVOLVED IN MEMBRANE FISSION: the reaction by which a vesicle neck can be severed to release a free vesicle. After almost 25 years of research, a wide variety of data from various techniques has been acquired on the mechanism by which dynamin breaks membranes. However, the literature may sometimes sound confusing, and the primary goal of this review will be to provide a stepping stone towards a potential consensus on how dynamin may work. I will then discuss the most recent findings in light of previous work, and the future possible lines of research in the field of dynamin.
Biochemistry Department, University of Geneva CH-1211 Geneva, Switzerland and Swiss National Centre for Competence in Research Programme Chemical Biology, CH-1211 Geneva Switzerland.
Aurélien
A
Roux