Clinical isolates of Salmonella enterica serovar Agona producing NDM-1 metallo-β-lactamase: first report from Pakistan.
We report two cases of infantile diarrhea due to multidrug-resistant, NDM-1 metallo-β-lactamase-producing Salmonella enterica serovar Agona from Pakistan. This study alerts toward possible risk of NDM-1 transmission to enteric fever pathogens and encourages microbiologists to consider active screening of carbapenem resistance in nontyphoidal Salmonella isolates.
Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan seema.irfan@aku.edu.
Seema
S
Irfan
Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan.
Erum
E
Khan
Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan.
Kauser
K
Jabeen
Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan.
Pushpa
P
Bhawan
Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, Public Health England, London, England.
Katie L
KL
Hopkins
Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, Public Health England, London, England.
Martin
M
Day
Department of Pathology Microbiology, The Aga Khan University, Karachi, Pakistan.
Amna
A
Nasir
Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, Public Health England, London, England.
Daniele
D
Meunier
Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, Public Health England, London, England.
Neil
N
Woodford
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D005243:Feces / Q000382:microbiology; D006801:Humans; D007223:Infant; D008826:Microbial Sensitivity Tests; D010154:Pakistan; D012480:Salmonella Infections / Q000188:drug therapy / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D001618:beta-Lactamases
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1