[The experimentally-based rationale for the application of the new methods designed to treat fungal adenoiditis in the children].
The objective of the present was to evaluate the influence of local anesthetics protargol, miramistin, chlorohexidine, and photodynamic therapy (PDT) on the polyresistant strain of Candida tropicalis isolated from a sick child presenting with fungal adenoiditis. In vitro experiments were designed to estimate the inactivation potential of the Candida tropicalis blastospore suspension (5.10⁷ CFU/ml) following the preliminary incubation with a 5 mcmol/l methylene blue solution. A Kreolka FDT apparatus operated at the 680 nm wavelength was employed as the source of radiation in a broad power and time ranges. Simultaneously, experiments were carried out to determine the minimum concentration of the protargol, miramistin, and chlorohexidine solutions inhibiting the growth of the same fungal strain. The minimum growth inhibitory concentrations of these solutions were found to be 0.1%, 0.005%, and 0.005% respectively. The photodynamic therapy using the minimal inhibitory dose of 150 J with a 5 min exposition and an output power of 0.5 W completely suppressed the growth of the Candida tropicalis colonies in the presence of methylene blue as the photosensitizer.
A I
AI
Kriukov
A Iu
AIu
Ivoĭlov
V Ia
VIa
Kunel'skaia
G B
GB
Shadrin
D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000494:pharmacology*; D041022:Candida tropicalis / Q000187:drug effects* / Q000472:pathogenicity; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008826:Microbial Sensitivity Tests; D010778:Photochemotherapy / Q000379:methods*; D014069:Tonsillitis / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome
D000891:Anti-Infective Agents, Local