Reduced content of chloroatranol and atranol in oak moss absolute significantly reduces the elicitation potential of this fragrance material.
BACKGROUND
Oak moss absolute, an extract from the lichen Evernia prunastri, is a valued perfume ingredient but contains extreme allergens.


OBJECTIVE
To compare the elicitation properties of two preparations of oak moss absolute: 'classic oak moss', the historically used preparation, and 'new oak moss', with reduced contents of the major allergens atranol and chloroatranol.


METHODS
The two preparations were compared in randomized double-blinded repeated open application tests and serial dilution patch tests in 30 oak moss-sensitive volunteers and 30 non-allergic control subjects.


RESULTS
In both test models, new oak moss elicited significantly less allergic contact dermatitis in oak moss-sensitive subjects than classic oak moss. The control subjects did not react to either of the preparations.


CONCLUSIONS
New oak moss is still a fragrance allergen, but elicits less allergic contact dermatitis in previously oak moss-sensitized individuals, suggesting that new oak moss is less allergenic to non-sensitized individuals.
Department of Dermatology and the Allergy Centre, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense C, Denmark; Dermatological Investigations Scandinavia, J. B. Winsløwparken 9, 5000, Odense C, Denmark.
Flemming
F
Andersen
Kirsten H
KH
Andersen
Armand
A
Bernois
Christophe
C
Brault
Magnus
M
Bruze
Hervé
H
Eudes
Catherine
C
Gadras
Anne-Cécile J
AC
Signoret
Kristian F
KF
Mose
Boris P
BP
Müller
Bernard
B
Toulemonde
Klaus Ejner
KE
Andersen
D000485:Allergens / Q000008:administration & dosage; D001547:Benzaldehydes / Q000008:administration & dosage; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests / Q000379:methods*; D010476:Perfume / Q000009:adverse effects / Q000737:chemistry*; D012116:Resins, Plant / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry; D018570:Risk Assessment; D013729:Terpenes / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry
D000485:Allergens; D001547:Benzaldehydes; D010476:Perfume; D012116:Resins, Plant; D013729:Terpenes; C493895:atranol; C487450:chloroatranol; C044724:oakmoss
allergic contact dermatitis; fragrances; patch test; risk assessment