Manipulated microenvironment in human papilloma virus-infected epithelial cells: is the CD40-CD154 pathway beneficial for host or virus?
In this issue, Tummers et al. (2014) demonstrate that high-risk human papilloma viruses (hrHPVs) attenuate the magnitude of responses to CD40 ligation and the epithelial cells' (ECs) capacity to attract leukocytes. These results suggest that hrHPVs can escape from host immune surveillance by modulating pro-inflammatory responses in infected ECs, resulting in persistent infections and potential carcinogenesis.
Department of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK.
Takatoshi
T
Shimauchi
Department of Dermatology and Academic Wound Healing, Institute of Infection and Immunity, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
Vincent
V
Piguet
D019013:CD40 Antigens / Q000502:physiology*; D004847:Epithelial Cells / Q000821:virology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular / Q000502:physiology*; D008297:Male; D027383:Papillomaviridae / Q000502:physiology*; D012867:Skin / Q000821:virology*
D019013:CD40 Antigens