Chasing the trace.
Event memories are stored in hippocampal-cortical networks. In this issue of Neuron, two studies, Cowansage et al. (2014) and Tanaka et al. (2014), tag active cells during memory encoding and optogenetically manipulate the activity of these "engram" cells during subsequent recall to reveal how hippocampal and cortical cell ensembles interact during retrieval.
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Adam
A
Santoro
Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Psychology, University of Toronto, Toronto, ON M5S 3GM, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: paul.frankland@sickkids.ca.
Paul W
PW
Frankland