Estimation of salivary and serum total sialic Acid levels in periodontal health and disease.
BACKGROUND
Chronic gingivitis and periodontitis are inflammatory diseases. An important function of host sialic acid is to regulate innate immunity. The aim of the study was to assess the concentration of Total sialic acid (TSA) in saliva and serum and also to find out their association if any, in periodontal health and disease.


METHODS
A total of 90 subjects were clinically examined and distributed into three groups (n=30) according to the periodontal status namely healthy, chronic gingivitis and chronic periodontitis.Clinical measurements including probing depth, clinical attachment level, gingival index, oral hygeine index were recorded .TSA concentration was determined in saliva and serum of all subjects.


RESULTS
In healthy group the mean salivary TSA level was 39.05mg/dl ±6.35(p<0.0001), mean serum TSA level was 49.75 mg/dl ± 4.87 (p<0.0001). In the chronic gingivitis group the mean salivary TSA level was 68.23 mg/dl ± 2.71 (p<0.0001), mean serum TSA level was 65.65 mg/dl ±3.56 (p<0.0001). In the chronic periodontitis group the mean salivary TSA was 81.33 mg/dl ±3.94 (p<0.0001), mean serum TSA level was 75.98 mg/dl ±3.58 (p<0.0001).


CONCLUSIONS
The present data indicates that salivary & serum TSA levels can differentiate between chronic periodontitis patients and normal individuals. Thus it can be used as an adjunct to diagnose, monitor response to therapy, to determine the current periodontal disease status and to assess the treatment outcomes.
Professor, Department of Periodontics, VSPM Dental College and Research Centre , Nagpur, India .
Surekha R
SR
Rathod
Post Graduate Student, Department of Periodontics, VSPM Dental College and Research Centre , Nagpur, India .
Farooque
F
Khan
Professor and Head, Department of Periodontics, VSPM Dental College and Research Centre , Nagpur, India .
Abhay P
AP
Kolte
Professor and Head, Department of Biochemistry, NKPS Institute of Medical Sciences , Nagpur, India .
Madhur
M
Gupta
Chronic periodontitis; N-Acetylneuraminic acid; Saliva; Serum