HIF-1α polymorphism in the susceptibility of cervical spondylotic myelopathy and its outcome after anterior cervical corpectomy and fusion treatment.
BACKGROUND
To investigate the association between the single nucleotide polymorphism (SNP) of hypoxia-inducible factor1 α (HIF-1α) and the susceptibility to cervical spondylotic myelopathy (CSM) and its outcome after surgical treatment.


METHODS
A total of 230 CSM patients and 284 healthy controls were recruited. All patients received anterior cervical corpectomy and fusion (ACF) and were followed for 12 months. The genotypes for two HIF-1α variants (1772C>T and 1790G>A) were determined.


RESULTS
In the present study, we found that the HIF-1α polymorphism at 1790G>A significantly affects the susceptibility to CSM and its clinical features, including severity and onset age. In addition, the 1790A>G polymorphism also determines the prognosis of CSM patients after ACF treatment. The GG genotype of 1790G>A polymorphism is associated with a higher risk to develop CSM, higher severity and earlier onset age. More importantly, we found that the 1790G>A polymorphism determines the clinical outcome in CSM patients who underwent ACF treatment.


CONCLUSIONS
Our findings suggest that the HIF-1α 1790G>A polymorphism is associated with the susceptibility to CSM and can be used as predictor for the clinical outcome in CSM patients receiving ACF treatment.
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Zhan-Chao
ZC
Wang
Department of Cardiology, Hangzhou Hospital, Nanjing Medical University & Hangzhou First Municipal Hospital, Hangzhou, China.
Xu-Wei
XW
Hou
Department of Orthopedics, Xinhua Hospital, Shanghai Jiaotong University; Shanghai, China.
Jiang
J
Shao
Department of Internal Medicine, Jinan 2nd People's Hospital, Jinan, China.
Yong-Jing
YJ
Ji
Department of Biostatistics, College of Public Health, Harbin Medical University, Harbin, Heilongjiang, 150081, China.
Lulu
L
Li
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Qiang
Q
Zhou
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Si-Ming
SM
Yu
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Yu-Lun
YL
Mao
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Hao-Jie
HJ
Zhang
Department of Orthopedics, Xinhua Hospital (Chongming), Shanghai Jiaotong University, Shanghai, China.
Ping-Chao
PC
Zhang
Department of Orthopedics, Xinhua Hospital, Shanghai Jiaotong University; Shanghai, China.
Hua
H
Lu
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002574:Cervical Vertebrae / Q000473:pathology* / Q000601:surgery*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055009:Spondylosis / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
D051795:Hypoxia-Inducible Factor 1, alpha Subunit