Pharmacology and Toxicology of Nav1.5-Class 1 anti-arrhythmic drugs.
Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of mechanisms. This review addresses the way in which drugs interact with the channel, and how these effects translate to clinical beneficial or detrimental effects. A further understanding of the details of channel function and of drug-channel interactions may lead to the development of safer and more effective antiarrhythmic therapies.
Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232.
Dan M
DM
Roden
drugs; proarrhythmia; sodium channel