Comparing glycemic indicators of prediabetes: a prospective study of obese Latino Youth.
OBJECTIVE
One hour (1-hr) glucose during an oral glucose tolerance test (OGTT) is an emerging biomarker for type 2 diabetes. We compared the predictive power of 1-hr glucose to traditional glycemic markers for prospectively identifying prediabetes in youth.


METHODS
Obese normoglycemic Latino youth (N = 116) were assessed at baseline for glycated hemoglobin (HbA1c), fasting, 1-hr, and 2-hr glucose during an OGTT and were followed for up to 8 yr for the development of prediabetes. Receiver operating characteristic (ROC) curves were used and a multivariable prediction model was developed.


RESULTS
The area under the 1-hr glucose ROC curve was the most powerful predictor of prediabetes over time [0.73, 95% confidence interval (CI) = 0.64-0.83]. However, combining all indicators into a single model was superior to individual marker models (0.77, 95% CI = 0.690.86).


CONCLUSIONS
These results further support the utility of 1-hr glucose during an OGTT as a prospective marker of diabetes risk in youth.
Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA.
Joon Young
JY
Kim
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.|Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Michael I
MI
Goran
Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
Claudia M
CM
Toledo-Corral
Department of Pediatrics, University of Southern California, Los Angeles, CA, USA.
Marc J
MJ
Weigensberg
Kinesiology Program, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ, USA.|College of Nursing and Health Innovation, Arizona State University, Phoenix, AZ, USA.
Gabriel Q
GQ
Shaibi
D000293:Adolescent; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications* / Q000208:ethnology; D011236:Prediabetic State / Q000175:diagnosis* / Q000208:ethnology; D011446:Prospective Studies
1-hr glucose; pediatrics; prediabetes; receiver operating characteristic curve