Management of refractory Leber miliary aneurysms with macular edema: a case report.
OBJECTIVE
To report a case study of a patient with Leber miliary aneurysms with macular edema refractory to various treatment modalities.


METHODS
This is a retrospective study of a 35-year-old man who had multiple Leber miliary aneurysms with exudation and edema involving the macula. The patient's data were collected from case notes over a 3-year period of management of the condition.


RESULTS
The patient's Leber miliary aneurysm with exudation and macular edema was refractory to various treatment modalities, including laser photocoagulation, anti-vascular endothelial growth factor injections, photodynamic therapy, and cryotherapy. However, recently, the patient showed a good response to treatment with intravitreal dexamethasone implants. His macular edema and vision have improved with these injections.


CONCLUSIONS
Intravitreal dexamethasone implants should be considered along with other treatment options when planning treatment of Leber miliary aneurysms. However, the long-term stability of the disease with these injections is not known.
*Southampton Eye Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; and †Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Sambath
S
Tiroumal
Andrew
A
Lotery
D000328:Adult; D000783:Aneurysm / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D004343:Drug Implants; D006801:Humans; D008269:Macular Edema / Q000188:drug therapy*; D008297:Male; D012164:Retinal Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D004343:Drug Implants; D003907:Dexamethasone