Role of the rs6923761 gene variant in glucagon-like peptide 1 receptor gene on cardiovascular risk factors and weight loss after biliopancreatic diversion surgery.
BACKGROUND
Studies of the glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) have been directed at identifying polymorphisms in the GLP-1R gene that may be a contributing factor in the pathogenesis of obesity.


OBJECTIVE
We decided to investigate the role of the rs6923761 GLP-1R polymorphism on outcomes after biliopancreatic diversion.


METHODS
A sample of 137 morbidly obese patients was operated. Weight, blood pressure, basal glucose and lipid profile were measured at the basal visit and at each following visit (basal, 3, 9, 12 and 18 months).


RESULTS
Body mass index, weight and waist circumference were lower in non-A allele carriers than A allele carriers 12 and 18 months after surgery. The initial weight percent loss at 12 months (45.6 vs. 39.8%; p < 0.05) or 18 months (49.6 vs. 41.3%; p < 0.05) was higher in patients with GG genotype than A allele carriers.


CONCLUSIONS
Our study showed a higher weight loss 12 and 18 months after bariatric surgery in GG variant than A allele carriers. The biochemical parameters and cardiovascular comorbidity rates improved similarly in both genotypes.
Center of Investigation of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain.
Daniel Antonio
DA
de Luis
David
D
Pacheco
Rocío
R
Aller
Olatz
O
Izaola
D000886:Anthropometry; D015904:Biliopancreatic Diversion; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications*; D011110:Polymorphism, Genetic; D011184:Postoperative Period; D018027:Receptors, Glucagon / Q000235:genetics*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D015431:Weight Loss; D044465:White People
C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon