Inhibition of PI3K/Akt/mTOR signaling pathway enhances the sensitivity of the SKOV3/DDP ovarian cancer cell line to cisplatin in vitro.
The activation of the PI3K/AKT/mTOR pathway plays a key role in ovarian cancer tumorigenesis, progression and chemotherapy resistance. This study aimed to explore the possible mechanism that PI-103, a dual inhibitor of phosphatidylinositide 3-kinase and mTOR, enhances the sensitivity of SKOV3/DDP ovarian cancer cell line to cisplatin chemotherapy. The results showed that PI-103 could significantly increase the sensitivity of SKVO3/DDP cells to cisplatin through inhibiting the activation of PI3K/Akt/mTOR signaling pathway and inducing cell cycle arrest and apoptosis.
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Yunlang
Y
Cai
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Xiaoqiang
X
Tan
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Jun
J
Liu
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Yang
Y
Shen
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Di
D
Wu
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Mulan
M
Ren
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Peilin
P
Huang
1 Department of Obstetrics & Gynecology, Zhongda Hospital, Southeast University, Nanjing 210009, China ; 2 Medical College, Southeast University, Nanjing 210009, China.
Dandan
D
Yu
PI3K/AKT/mTOR; cisplatin; ovarian cancer