Total synthesis of the proposed structure of astakolactin.
The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.
Department of Applied Chemistry, Tokyo University of Science,1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Takayuki
T
Tonoi
Department of Applied Chemistry, Tokyo University of Science,1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Keisuke
K
Mameda
Department of Applied Chemistry, Tokyo University of Science,1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Moe
M
Fujishiro
Department of Applied Chemistry, Tokyo University of Science,1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Yutaka
Y
Yoshinaga
Department of Applied Chemistry, Tokyo University of Science,1-3 Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
Isamu
I
Shiina
MNBA; aldol reaction; astakolactin; lactonization; terpenoids