Retinal necrosis secondary to inadvertent intravitreal methylprednisolone acetate (depo-medrol) injection during pars plana vitrectomy.
OBJECTIVE
Methylprednisolone acetate (Depo-Medrol, Pfizer, New York) is a depot corticosteroid that is commonly injected periorbitally to treat various ophthalmologic conditions. Accidental intravitreal injections secondary to globe perforations have resulted in rapid retinal toxicity. To their knowledge, the authors report the first case of inadvertent intravitreal methylprednisolone acetate injection during pars plana vitrectomy.


METHODS
Report of a case of inadvertent intravitreal injection of methylprednisolone acetate, mistaken as triamcinolone acetonide, during repeated retinal detachment repair.


RESULTS
The affected eye had loss of vision, afferent pupillary defect, optic nerve atrophy, retinal necrosis, retinal vascular damage, and recurrent retinal detachment.


CONCLUSIONS
Methylprednisolone acetate administered during vitrectomy causes severe retinal toxicity and complicates retinal detachment repair. It is important to use measures to avoid erroneous intravitreal injections during vitrectomy.
From the Retina Service, Department of Ophthalmology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York.
Yoshihiro
Y
Yonekawa
Grace
G
Sun
Donald J
DJ
D'Amico
R V Paul
RV
Chan