γ-Butyrolactone, cytochalasin, cyclic carbonate, eutypinic acid, and phenalenone derivatives from the soil fungus Aspergillus sp. PSU-RSPG185.
Purification of an extract from the broth of the soil fungus Aspergillus sp. PSU-RSPG185 resulted in the isolation of two new cyclic carbonate derivatives, aspergillusols A (1) and B (2), and one new eutypinic acid derivative, aspergillusic acid (3), along with six known secondary metabolites. Compounds 1 and 2 contain an unusual cyclic-carbonate functionality. In addition, the mycelial extract afforded two new phenalenones, aspergillussanones A (4) and B (5), one new cytochalasin, aspergilluchalasin (6), and one new γ-butyrolactone, aspergillulactone (7). Their structures were established by interpretation of spectroscopic evidence. Compound 4 exhibited weak activity toward KB and Vero cells with IC50 values of 48.4 and 34.2 μM, respectively.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University , Hat Yai, Songkhla 90112, Thailand.
Vatcharin
V
Rukachaisirikul
Nachamon
N
Rungsaiwattana
Saranyoo
S
Klaiklay
Souwalak
S
Phongpaichit
Kawitsara
K
Borwornwiriyapan
Jariya
J
Sakayaroj
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D001230:Aspergillus / Q000737:chemistry*; D002522:Chlorocebus aethiops; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D015394:Molecular Structure; D043803:Phenalenes / Q000302:isolation & purification; D012988:Soil Microbiology; D014709:Vero Cells
D003572:Cytochalasins; D043803:Phenalenes; C038036:phenalen-1-one; D015107:4-Butyrolactone