Aged mice repeatedly injected with plasma from young mice: a survival study.
It was reported using various biological models that the administration of blood factors from young animals to old animals could rejuvenate certain functions. To assess the anti-aging effect of young blood we tested the influence of repeated injections of plasma from young mice on the lifespan of aged mice. One group of 36 CBA/Ca female mice aged 10-12 months was treated by repeated injections of plasma from 2- to 4-month-old females (averaging 75-150 μL per injection, once intravenously and once intraperitoneally per week for 16 months). Their lifespan was compared to a control group that received saline injections. The median lifespan of mice from the control group was 27 months versus 26.4 months in plasma-treated group; the repeated injections of young plasma did not significantly impact either median or maximal lifespan.
D.F. Chebotarev State Institute of Gerontology NAMS , Lab Pathophysiology and Immunology, Kyiv, Ukraine .
Dmytro
D
Shytikov
D.F. Chebotarev State Institute of Gerontology NAMS , Lab Pathophysiology and Immunology, Kyiv, Ukraine .
Olexiy
O
Balva
Heales (Healthy Life Extension Society) , Paris, France .
Edouard
E
Debonneuil
National University , Department of Mathematics and Natural Sciences, Los Angeles, California.
Pavel
P
Glukhovskiy
D.F. Chebotarev State Institute of Gerontology NAMS , Lab Pathophysiology and Immunology, Kyiv, Ukraine .
Iryna
I
Pishel
aging; immunology