Focal retinal pigment epithelium breaks in central serous chorioretinopathy.
OBJECTIVE
To describe new evidence supporting a theory on the etiology of the focal retinal pigment epithelium (RPE) leak in central serous chorioretinopathy (CSC).


METHODS
The records of two patients with CSC were reviewed, including examination details and results of fluorescein angiography, fundus autofluorescence imaging, and optical coherence tomography (OCT).


RESULTS
A defect in the RPE monolayer demonstrated with OCT that corresponded to the site of the focal leak shown by fluorescein angiography was found in both patients.


CONCLUSIONS
The focal leak shown by fluorescein angiography in patients with active CSC is caused by an RPE defect in at least some cases. This finding supports a previously reported theory on the pathogenesis of CSC.
From the *Department of Ophthalmology, Henry Ford Health Systems, Detroit, Michigan; †The LuEsther T. Mertz Retina Research Center of Manhattan Eye, Ear, and Throat Hospital, and Vitreous-Retina-Macula Consultants of New York, New York, New York; the ‡Department of Clinic Physiopathology, Eye Clinic, University of Torino, Torino, Italy; and the §Department of Ophthalmology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois.
Michael D
MD
Ober
Chiara M
CM
Eandi
Lee M
LM
Jampol
Howard F
HF
Fine
Lawrence A
LA
Yannuzzi