Objective physical activity and weight loss in adults: the step-up randomized clinical trial.
OBJECTIVE
To examine the amount of objectively measured MVPA and LPA that is associated with long-term weight loss and the maintenance of clinically significant weight loss.


METHODS
Adults (N = 260; BMI: 25 to <40 kg/m(2) ; age: 18-55 years) participated in an 18-month behavioral weight loss intervention and were prescribed a low-calorie diet and increased physical activity. Change in weight and objectively measured physical activity were assessed. MVPA > 10 (MET-min/week) was computed from bouts >10 min and >3.0 METs and MVPA < 10 was computed from bouts <10 min in duration and >3.0 METs. LPA was computed from bouts between 1.5 to <3.0 METs.


RESULTS
When grouped on percent weight loss at 18 months, there was a significant group × time interaction effect (P < 0.0001) for both MVPA > 10 and LPA, with both measures being significantly greater at 18 months in those with >10% weight loss. Similar results were observed for MVPA > 10 and LPA with participants grouped on achieving >10% weight loss at 6 months and sustaining this at 18 months.


CONCLUSIONS
MVPA > 10 of 200-300 min per week, coupled with increased amounts of LPA, are associated with improved long-term weight loss. Interventions should promote engagement in these amounts and types of physical activity.
Department of Health and Physical Activity, Physical Activity and Weight Management Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
John M
JM
Jakicic
Deborah F
DF
Tate
Wei
W
Lang
Kelliann K
KK
Davis
Kristen
K
Polzien
Rebecca H
RH
Neiberg
Amy D
AD
Rickman
Karen
K
Erickson
D000293:Adolescent; D000328:Adult; D001521:Behavior Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D009765:Obesity / Q000628:therapy*; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult