Nonsense-mediated RNA decay: at the 'cutting edge' of regulated snoRNA production.
Production of multiple functional RNAs from a single primary transcript is an extremely efficient use of genetic information, although it complicates the ability of the cell to independently regulate the production of each RNA. For the case of small nucleolar RNAs (snoRNAs) encoded within introns of mRNA genes, Lykke-Andersen and colleagues (pp. 2498-2517) demonstrated that alternative splicing and the SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which RNAs accumulate.
Department of Biochemistry and Biophysics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA; wilusz@mail.med.upenn.edu jeffrey.wilusz@colostate.edu.
Jeremy E
JE
Wilusz
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA wilusz@mail.med.upenn.edu jeffrey.wilusz@colostate.edu.
Jeffrey
J
Wilusz
D017398:Alternative Splicing; D018389:Codon, Nonsense / Q000235:genetics; D005786:Gene Expression Regulation; D006801:Humans; D007438:Introns / Q000235:genetics; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism; D020537:RNA, Small Nucleolar / Q000096:biosynthesis*; D019098:Telomerase / Q000378:metabolism; D004722:Endoribonucleases
D018389:Codon, Nonsense; D012333:RNA, Messenger; D020537:RNA, Small Nucleolar; D019098:Telomerase; C512261:SMG6 protein, human; D004722:Endoribonucleases
RNA decapping; endonucleolytic RNA cleavage; intron-encoded snoRNA; nonsense-mediated decay; regulation of snoRNA expression; snoRNA host genes