Efficient delivery of therapeutic miRNA nanocapsules for tumor suppression.
miRNA nanocapsules are synthesized with enhanced stability for miRNA delivery with high transduction efficiency, offering a novel class of miRNA vectors for cancer therapy.
School of Material Science and Engineering, Tianjin University, Tianjin, 300072, China; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, California, 90095, USA; Department of Neurosurgery, Tianjin Medical University General Hospital, Laboratory of Neuro-Oncology, Tianjin Neurological Institute, Tianjin, 300052, China; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government, Tianjin, 300052, China.
Chaoyong
C
Liu
Jing
J
Wen
Yubin
Y
Meng
Kailiang
K
Zhang
Jialin
J
Zhu
Yu
Y
Ren
Xiaomin
X
Qian
Xubo
X
Yuan
Yunfeng
Y
Lu
Chunsheng
C
Kang
D020106:Acrylamide / Q000737:chemistry; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival; D055785:Gene Knockdown Techniques; D015316:Genetic Therapy / Q000295:instrumentation* / Q000379:methods*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D053769:Nanocapsules / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D058105:Polymerization; D016372:RNA, Antisense / Q000378:metabolism / Q000627:therapeutic use; D014161:Transduction, Genetic
C524940:MIRN21 microRNA, human; D008689:Methacrylates; D035683:MicroRNAs; D053769:Nanocapsules; D016372:RNA, Antisense; D020106:Acrylamide; C004919:ethylene dimethacrylate
angiogenesis; cancer therapy; miR-21; miRNA delivery; nanocapsules