Palladium catalyzed Csp2-H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals.
A novel strategy for direct aryl hydroxylation via Pd-catalysed Csp(2)-H activation through an unprecedented hydroxyl radical transfer from 1,4-dioxane, used as a solvent, is reported with bio relevant and sterically hindered heterocycles and various acyclic functionalities as versatile directing groups.
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, Punjab, India. akchakraborti@niper.ac.in akchakraborti@rediffmail.com.
Kapileswar
K
Seth
Manesh
M
Nautiyal
Priyank
P
Purohit
Naisargee
N
Parikh
Asit K
AK
Chakraborti
D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D004146:Dioxanes / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry*; D006900:Hydroxylation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D011789:Quantum Theory
D004146:Dioxanes; D017665:Hydroxyl Radical; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; C025223:1,4-dioxane