Low coherence interferometry approach for aiding fine needle aspiration biopsies.
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.
Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.
Ernest W
EW
Chang
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom, Boston, Massachusetts 02114, United States.
Joseph
J
Gardecki
Massachusetts General Hospital, Department of Pathology, 55 Fruit Street, Boston, Massachusetts 02114, United States.
Martha
M
Pitman
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom, Boston, Massachusetts 02114, United States.
Eric J
EJ
Wilsterman
Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.
Ankit
A
Patel
Wellman Center for Photomedicine, Massachusetts General Hospital, 40 Blossom, Boston, Massachusetts 02114, United States.
Guillermo J
GJ
Tearney
Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.
Nicusor
N
Iftimia
D000273:Adipose Tissue / Q000737:chemistry; D000465:Algorithms; D000818:Animals; D044963:Biopsy, Fine-Needle / Q000379:methods*; D045744:Cell Line, Tumor; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007368:Interferometry / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry; D051379:Mice; D018482:Muscle, Skeletal / Q000737:chemistry; D012372:ROC Curve