[The influence of hormonal therapy on the development of rhinitis in the pregnant women].
The objective of the present study was to evaluate the influence of hormonal therapy used to correct the hormonal status of the pregnant women during different periods of gestation on the development of the nasal obstruction symptoms. A total of 53 case histories of the pregnant women (urban residents) were available for the analysis. In 2012, all the patients were under observation of an obstetrician-gyneciologist based at an outpatient setting. 16 of them (30.2%) suffered stuffness in the nose that was especially well pronounced during the II and III trimesters (37.5% in each trimester). Mild stuffness predominated over the moderate and strong ones (62.5, 18.75 and 18.75% respectively). The disturbed hormonal status was documented in 13 (81.75%) pregnant women in the form of reduced progesterone and human CG-beta levels and increased serum DHEA-C concentration. The hormonal status was corrected during the I and II trimesters. The women having very high serum DHEA-C concentration were treated with metypred; those with the low progesterone level were given utrogestan. In both groups, the diseases was especially well manifested in the early II trimester. It is conjectured that therapy with the use of progesterone and glucocorticoid-based preparations had no appreciable effect on the development of rhinitis in the pregnant women.
V M
VM
Frolov
R A
RA
Kornienko
V Ia
VIa
Starzhinskaia
M V
MV
Marchenko
D000328:Adult; D005260:Female; D006728:Hormones / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D012220:Rhinitis / Q000139:chemically induced*
D006728:Hormones