The Effects of Hydroalchoholic Extract of Teucrium polium L. on Hypertension Induced by Angiotensin II in Rats.
BACKGROUND
Antispasmodic and vasorelaxant effects of Teucrium polium L. (TP) were mentioned in former studies, so we attempted to evaluate the eventual preventive effect of TP in an acute experimental model of hypertension induced by angiotensin II (Ang II).


METHODS
Forty-eight male Wistar rats were divided randomly into six groups (n = 8); control Group (C), which received only saline, group Ang II; which received Ang II (300 ng/min, IV), group losartan (Los); which received Los (10 mg/kg, IV) before Ang II injection, three groups of TP 100, TP 200, and TP 400; which received different doses of TP extract (100, 200 and 400 mg/kg, IP, respectively) before Ang II application. After cannulation of the femoral artery, mean arterial blood pressure (MAP) and heart rate (HR) was continuously measured and recorded during the experiments. Comparisons were performed using t-test with SPSS software, version 16 (SPSS, Chicago, IL).


RESULTS
MAP and HR in Ang group were significantly higher than the control group (P < 0.001), MAP in group Los significantly was lower than Ang group (P < 0.001) and pretreatment with three doses of TP extract also inhibited increasing of MAP after Ang II injection (P < 0.001). Los also inhibited the increase of HR due to Ang II (P < 0.001), but none of three doses of TP extract had a protective effect on tachycardia induced by Ang II.


CONCLUSIONS
It seems TP extract could be effective in preventing of high blood pressure induced by Ang II pathway activation but could not have remarkable efficacy for improving the created tachycardia.
Department of Physiology, Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
Maryam
M
Mahmoudabady
Department of Physiology, Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
Mohammad Naser
MN
Shafei
Department of Physiology, Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
Saeed
S
Niazmand
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran.
Esmaeel
E
Khodaee
Angiotensin II; Teucrium polium; hypertension; rat