The Future of D-Cycloserine and Other Cognitive Modifiers in Obsessive-Compulsive and Related Disorders.
Variants of exposure therapy are effective for treating obsessive-compulsive and related disorders (OCRDs). However, significant numbers of patients do not respond adequately to exposure therapy resulting in continued distress and functional impairment. Therefore, novel approaches to augmenting exposure therapy are needed to adequately treat non- and partial-responders. Emerging research suggests that interventions that augment learning and memory processes associated with exposure therapy (i.e., extinction training) may display promise in enhancing treatment response in OCRDs. As the most studied example, d-cycloserine (DCS) is a relatively safe cognitive enhancer that appears to accelerate treatment gains associated with exposure therapy. This article reviews research on the use of DCS and other putative cognitive modifiers as they relate to the treatment (or prospective treatment) of obsessive-compulsive disorder and other OCRDs.
University of Arizona, Box 210069 Tucson, AZ 85721-0069.
Michael L
ML
Sulkowski
Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, .
Daniel A
DA
Geller
University of South Florida, Department of Pediatrics, 880 6th Street South, Suite 460, Box 7523, St. Petersburg, FL 33701, .
Adam B
AB
Lewin
University of South Florida, Department of Pediatrics, 880 6th Street South, Suite 460, Box 7523, St. Petersburg, FL 33701, , ; Universitry of South Florida, Department of Psychiatry, 880 6th Street South, Suite 460, Box 7523, St. Petersburg, FL 33701, Phone: (727) 767-8230, Fax: (727) 767-7786.
Tanya K
TK
Murphy
Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, .
Andrew
A
Mittelman
Massachusetts General Hospital, Department of Psychiatry, 55 Fruit Street, Boston, MA 02114, .
Ashley
A
Brown
University of South Florida, Department of Pediatrics, 880 6th Street South, Suite 460, Box 7523, St. Petersburg, FL 33701, , ; Universitry of South Florida, Department of Psychiatry, 880 6th Street South, Suite 460, Box 7523, St. Petersburg, FL 33701, Phone: (727) 767-8230, Fax: (727) 767-7786.
Eric A
EA
Storch
Brain-derived neurotrophic factor; Cognitive enhancer; D-cycloserine; Glucocorticoids; Memory reconsolidation; Obsessive-compulsive disorder; Yohimbine