The study of the effect of thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate on blood coagulation upon intragastric and subcutaneous administration.
We studied the effects of subcutaneous and intragastrical administration of synthesized compound thiazoline ammonium 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (FS 169) on blood clotting in vitro and in vivo in rabbits. Compound FS 169 significantly prolongs clotting time in vitro; its activity is comparable with that of heparin. When administered subcutaneously, the substance is rapidly absorbed and significantly reduces blood clotting by 102.9% from the initial clotting time within 30 min. After intragastric administration of the substance, maximum activity (133.0% of the baseline clotting time) was observed in 30 min after administration. The drug effect upon subcutaneous and intragastrical administration lasted for 2 h.
Department of Physiology, Perm' State Pharmaceutical Academy, Ministry of Health of the Russian Federation, Moscow, Russia, allaperm@list.ru.
A V
AV
Starkova
F V
FV
Sobin
B Ya
BY
Syropyatov
N A
NA
Pulina
D000085:Acetates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001555:Benzene Derivatives / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001777:Blood Coagulation; D004353:Drug Evaluation, Preclinical; D006493:Heparin / Q000008:administration & dosage; D007279:Injections, Subcutaneous; D011817:Rabbits; D014753:Vinyl Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014914:Whole Blood Coagulation Time
C586859:4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate; D000085:Acetates; D000925:Anticoagulants; D001555:Benzene Derivatives; D014753:Vinyl Compounds; D006493:Heparin