Spasticity in disorders of consciousness: a behavioral study.
BACKGROUND
Spasticity is a frequent complication after severe brain injury, which may impede the rehabilitation process and diminish the patients' quality of life.


OBJECTIVE
We here investigate the presence of spasticity in a population of non-communicative patients with disorders of consciousness. We also evaluate the correlation between spasticity and potential factors of co-morbidity, frequency of physical therapy, time since insult, presence of pain, presence of tendon retraction, etiology and diagnosis.


METHODS
Cross-sectional study.


METHODS
University Hospital of Liège, Belgium.


METHODS
Sixty-five patients with chronic (>3 months post insult) disorders of consciousness were included (22 women; mean age: 44±14 y; 40 with traumatic etiology; 40 in a minimally conscious state; time since insult: 39±37 months).


METHODS
Spasticity was measured with the Modified Ashworth Scale (MAS) and pain was assessed using the Nociception Coma Scale-Revised (NCS-R).


RESULTS
Out of 65 patients, 58 demonstrated signs of spasticity (89%; MAS≥1), including 40 who showed severe spasticity (61.5%; MAS≥3). Patients with spasticity receiving anti-spastic medication were more spastic than unmedicated patients. A negative correlation was observed between the severity of spasticity and the frequency of physical therapy. MAS scores correlated positively with time since injury and NCS-R scores. We did not observe a difference of spasticity between the diagnoses.


CONCLUSIONS
A large proportion of patients with disorders of consciousness develop severe spasticity, possibly affecting their functional recovery and their quality of life. The observed correlation between degrees of spasticity and pain scores highlights the importance of pain management in these patients with altered states of consciousness. Finally, the relationship between spasticity and treatment (i.e., pharmacological and physical therapy) should be further investigated in order to improve clinical care.


CONCLUSIONS
Managing spasticity at first signs could improve rehabilitation of patients with disorders of consciousness and maximize their chances of recovery. In addition, decreasing this trouble could allow a better quality of life for these non-communicative patients.
Coma Science Group, Giga Research, Cyclotron Research Centre and Neurology Department, University and University Hospital of Liège, Liège, Belgium - athibaut@ulg.ac.be.
F A
FA
Thibaut
C
C
Chatelle
S
S
Wannez
T
T
Deltombe
J
J
Stender
C
C
Schnakers
S
S
Laureys
O
O
Gosseries
D000328:Adult; D001930:Brain Injuries / Q000150:complications / Q000534:rehabilitation; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003243:Consciousness / Q000502:physiology*; D003430:Cross-Sectional Studies; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009128:Muscle Spasticity / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation*; D018458:Persistent Vegetative State / Q000209:etiology / Q000503:physiopathology / Q000534:rehabilitation*; D011379:Prognosis; D020127:Recovery of Function