Solid-phase synthesis of C-terminal azapeptides.
The solid-phase synthesis of azapeptides possessing a C-terminal aza-residue has been accomplished by a protocol featuring regioselective alkylation of benzhydrylidene-aza-glycinamide and illustrated by the syntheses of [aza-Lys(6)] growth-hormone-releasing peptide-6 analogs.
Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-Ville, Montréal, Québec, H3C 3J7, Canada.
Ngoc-Duc
ND
Doan
Jinqiang
J
Zhang
Mariam
M
Traoré
Winnie
W
Kamdem
William D
WD
Lubell
D000478:Alkylation; D000818:Animals; D001372:Aza Compounds / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013329:Structure-Activity Relationship
D001372:Aza Compounds; D010455:Peptides
C-terminal azapeptides; acylation of semicarbazide; benzhydrylidene-protecting group; regioselective alkylation