A first-degree relative with diabetes mellitus is an important risk factor for rural Thai villagers to develop type 2 diabetes mellitus.
The screening of 609 villagers in rural areas of northeastern Thailand resulted in the detection of 110 (18.1%) new cases of type 2 diabetes (T2DM). The diagnoses were made on the basis of a glycated hemoglobin (HbA1c) value ≤ 6.5%. Among all those screened, 243 (40%) reported having a father or mother with T2DM. Among the new cases, 66 (60%) reported a first-degree relative, predominantly their mothers, who had the disease. Together with age and the body mass index, a mother or father with DM was strong risk factor for the development of T2DM (adjusted odds ratio = 2.9, 95% confidence interval = 1.84-4.57) when compared with the absence of a first-degree relative with DM. It is concluded that family history of a first-degree relative is an important additional information that might improve the validity of the screening procedure.
Khon Kaen University, Khon Kaen, Thailand.
Benja
B
Muktabhant
Khon Kaen University, Khon Kaen, Thailand.
Pattara
P
Sanchaisuriya
Na Klang Hospital, Na Klang, Nong Bua Lamphu Province, Thailand.
Mantana
M
Trakulwong
Na Klang Hospital, Na Klang, Nong Bua Lamphu Province, Thailand.
Rumpai
R
Mingchai
Khon Kaen University, Khon Kaen, Thailand f_schelp@kku.ac.th.
Frank P
FP
Schelp
D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000235:genetics*; D005220:Fathers / Q000706:statistics & numerical data; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data; D016017:Odds Ratio; D015203:Reproducibility of Results; D012307:Risk Factors; D012423:Rural Health / Q000706:statistics & numerical data*; D013785:Thailand
D006442:Glycated Hemoglobin
Thailand; first-degree relative; genetic; type 2 diabetes mellitus