Transient blood flow in elastic coronary arteries with varying degrees of stenosis and dilatations: CFD modelling and parametric study.
In this paper, we have analysed pulsatile flow through partially occluded elastic arteries, to determine the haemodynamic parameters of wall shear stress (WSS), wall pressure gradient and pressure drops (ΔP), contributing to enhanced flow resistance and myocardial ischaemic regions which impair cardiac contractility and cause increased work load on the heart. In summary, it can be observed that stenoses in an artery significantly influence the haemodynamic parameters of wall shear stress and pressure drop in contrast to dilatations case. This deduces that stenosis plays a more critical role in plaque growth and vulnerability in contrast to dilatation, and should be the key element in cardiovascular pathology and diagnosis. Through quantitative analysis of WSS and ΔP, we have provided a clearer insight into the haemodynamics of atherosclerotic arteries. Determination of these parameters can be helpful to cardiologists, because it is directly implicated in the genesis and development of atherosclerosis.
a Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , 1068 Xueyuan Boulevard, Xili Nanshan, Shenzhen 518055 , P.R. China.
Jianhuang
J
Wu
Guiying
G
Liu
Wenhua
W
Huang
Dhanjoo N
DN
Ghista
Kelvin K L
KK
Wong
D001783:Blood Flow Velocity; D003198:Computer Simulation; D003251:Constriction, Pathologic / Q000503:physiopathology; D003326:Coronary Circulation / Q000502:physiology*; D003331:Coronary Vessels / Q000503:physiopathology*; D004106:Dilatation; D004548:Elasticity; D006439:Hemodynamics; D006801:Humans; D008955:Models, Cardiovascular; D011312:Pressure; D033081:Shear Strength; D013314:Stress, Mechanical
atherosclerosis; dilatations; elastic artery; fluid–structure interaction; stenosis