Innate immune proteins as biomarkers for CNS injury: critical evaluation (WO2013119673 A1).
BACKGROUND
Injuries to the CNS represent a major global health problem. CNS injuries cause the elevation of many proteins, including innate immune proteins in biological fluids, such as the cerebrospinal fluid (CSF). These innate immune proteins can be considered as biomarkers to predict the severity of CNS injury in patients.


METHODS
This invention describes a method for the diagnosis/prognosis, treatment or rehabilitation efforts, and monitoring of post-treatment responses after CNS injuries in a patient, based on the detection and quantification of the expression levels of protein components of inflammasomes in the CSF. This study evaluates the elevated levels of inflammasome proteins such as NLRP1 (NAcht leucine-rich-repeat protein 1), ASC and caspase-1 in biological samples as important biomarkers that can assess the extent of neuroinflammation and reflect the magnitude of inflammation-induced damage following CNS injury.


CONCLUSIONS
Although inflammasome proteins may be of great clinical significance in the near future, a more detailed analysis of inflammasome proteins needs to be taken into account for the prognosis and treatment of diverse CNS conditions. Moreover, the potential inflammasome biomarker candidates have to be validated in a large number of patients for an extended period post-injury to further support clinical relevance.
Department of Pharmacology, Brain Science and Engineering Institute, BK21 PLUS KNU Biomedical Convergence Program, Kyungpook National University School of Medicine , Daegu , Republic of Korea +82 53 420 4835 ; +82 53 256 1566 ; ksuk@knu.ac.kr.
Mithilesh Kumar
MK
Jha
Ho-Won
HW
Lee
Sang Yun
SY
Kim
Kyoungho
K
Suk
D015415:Biomarkers / Q000378:metabolism*; D002490:Central Nervous System / Q000276:immunology / Q000293:injuries* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000378:metabolism; D010330:Patents as Topic; D011379:Prognosis; D011506:Proteins / Q000378:metabolism; D015599:Trauma Severity Indices
D015415:Biomarkers; D058847:Inflammasomes; D011506:Proteins
CNS injury; biomarker; inflammasome protein; innate immune protein; neuroinflammation; therapy