Case of paraneoplastic retinopathy with retinal ON-bipolar cell dysfunction and subsequent resolution of ERGs.
OBJECTIVE
To report a patient with cancer-associated retinopathy and retinal ON-bipolar cell dysfunction who had a resolution of the electroretinograms (ERGs) after a resection of an ovarian cancer and chemotherapy.


METHODS
A 71-year-old Japanese female patient visited us complaining of night blindness and photopsia in both eyes for 6 months. Her visual acuity was 20/20 in both eyes, and fundus examination, fluorescence angiography, and optical coherence tomography showed no abnormalities in both eyes. The rod responses of the ERGs were absent and bright-flash ERGs were electronegative. The ON responses of the focal macular ERGs and full-field long-flash ERGs were absent. These ERG findings indicate an ON-bipolar cell dysfunction. A general physical examination revealed the presence of ovarian cancer. After resection of the ovarian cancer and adjuvant chemotherapy, the ERGs of the left eye completely recovered within 2 years and those of right eye recovered subsequently. The autoantibody against transient receptor potential melastatin 1 (TRPM1) was not detected in the serum.


CONCLUSIONS
Our case demonstrates that retinal ON-bipolar dysfunction can be caused by ovarian cancer. Our case indicates that some autoantibodies against other than TRPM1 might cause transient dysfunction of retinal ON-bipolar cells.
Department of Ophthalmology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya City, Aichi, 466-8550, Japan, ueno@med.nagoya-u.ac.jp.
Shinji
S
Ueno
Ayami
A
Nakanishi
Kayo
K
Nishi
Shiro
S
Suzuki
Hiroko
H
Terasaki
D000368:Aged; D017024:Chemotherapy, Adjuvant; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D059545:Paraneoplastic Syndromes, Ocular / Q000209:etiology* / Q000503:physiopathology; D010775:Photic Stimulation; D051245:Retinal Bipolar Cells / Q000473:pathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D041623:Tomography, Optical Coherence