Fetal size in a rural melanesian population with minimal risk factors for growth restriction: an observational ultrasound study from Papua New Guinea.
We conducted a prospective longitudinal study of fetal size in rural Papua New Guinea (PNG) involving 439 ultrasound-dated singleton pregnancies with no obvious risk factors for growth restriction. Sonographically estimated fetal weights (EFWs; N = 788) and birth weights (N = 376) were included in a second-order polynomial regression model (optimal fit) to generate fetal weight centiles. Means for specific fetal biometric measurements were also estimated. Fetal weight centiles from a healthy PNG cohort were consistently lower than those derived from Caucasian and Congolese populations, which overestimated the proportion of fetuses measuring small for gestational age (SGA; < 10th centile). Tanzanian and global reference centiles (Caucasian weight reference adapted to our PNG cohort) were more similar to those observed in our cohort, but the global reference underestimated SGA. Individual biometric measurements did not differ significantly from other cohorts. In rural PNG, a locally derived nomogram may be most appropriate for detection of SGA fetuses.
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Holger W
HW
Unger
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Stephan
S
Karl
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Regina A
RA
Wangnapi
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Peter
P
Siba
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Glen
G
Mola
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Jane
J
Walker
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Ivo
I
Mueller
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain.
Maria
M
Ome
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Australia; Walter and Eliza Hall Institute (WEHI), Parkville, Australia; Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea; Department of Obstetrics and Gynaecology, University of Papua New Guinea, Port Moresby, Papua New Guinea; Royal Infirmary of Edinburgh, Edinburgh, United Kingdom; Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain sroger@unimelb.edu.au.
Stephen J
SJ
Rogerson
D000293:Adolescent; D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation; D005333:Fetus; D006801:Humans; D010219:Papua New Guinea; D011247:Pregnancy; D012307:Risk Factors; D012424:Rural Population; D016216:Ultrasonography, Prenatal; D055815:Young Adult