Progressive optical coherence tomography deterioration in chloroquine maculopathy.
OBJECTIVE
To report optical coherence tomography (OCT) progressive changes in chloroquine maculopathy.


METHODS
Observational case report.


METHODS
Both eyes of a patient with chloroquine maculopathy were examined serially with OCT.


RESULTS
OCT demonstrated diffuse retinal thinning involving the fovea and perifoveal area in each eye, particularly involving the outer retina, with loss of the photoreceptor outer hyperreflective lamina proximal to the lamina corresponding to the retinal pigment epithelium (RPE). The temporal nerve fiber layer was mildly thinned. Repeat OCT showed progressive macular thinning.


CONCLUSIONS
OCT findings are consistent with histopathologic studies that advanced chloroquine toxicity affects the nerve fiber layer and the outer retinal layers, and confirm reports that severe maculopathy may progress despite cessation of therapy. The possible use of OCT in screening of patients at risk for macular toxicity is suggested.
From the *Department of Ophthalmology, Emory University, Atlanta, Georgia; and †Midwest Retina Consultants and University of Illinois Eye and Ear Infirmary, Chicago, Illinois.
Chris
C
Bergstrom
Enrique
E
Garcia-Valenzuela