A click-and-release approach to CO prodrugs.
Carbon monoxide belongs to the family of signaling molecules and has been shown to possess therapeutic effects. Similar to NO, safe delivery of CO is a key issue in developing CO-based therapeutics. Herein we report a "click and release" CO-prodrug approach, which allows the release of CO under physiological conditions without the need for light irradiation. The system releases CO in a triggered and controllable manner and possesses the potential of tunable release rates.
Department of Chemistry, Georgia State University, Atlanta, 30303-3083, Georgia. wang@gsu.edu.
Danzhu
D
Wang
Emilie
E
Viennois
Kaili
K
Ji
Krishna
K
Damera
Alexander
A
Draganov
Yueqing
Y
Zheng
Chaofeng
C
Dai
Didier
D
Merlin
Binghe
B
Wang
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000494:pharmacology; D002248:Carbon Monoxide / Q000737:chemistry*; D045744:Cell Line, Tumor; D061565:Cycloaddition Reaction; D003517:Cyclopentanes / Q000737:chemistry / Q000494:pharmacology; D008027:Light; D008070:Lipopolysaccharides / Q000633:toxicity; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D011355:Prodrugs / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011789:Quantum Theory; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D001643:Bridged Bicyclo Compounds; D003517:Cyclopentanes; D008070:Lipopolysaccharides; D011355:Prodrugs; D014409:Tumor Necrosis Factor-alpha; C556617:bicyclo(6.1.0)nonyne; C009440:tetraphenylcyclopentadienone; D002248:Carbon Monoxide