Generalized cable formalism to calculate the magnetic field of single neurons and neuronal populations.
Neurons generate magnetic fields which can be recorded with macroscopic techniques such as magnetoencephalography. The theory that accounts for the genesis of neuronal magnetic fields involves dendritic cable structures in homogeneous resistive extracellular media. Here we generalize this model by considering dendritic cables in extracellular media with arbitrarily complex electric properties. This method is based on a multiscale mean-field theory where the neuron is considered in interaction with a "mean" extracellular medium (characterized by a specific impedance). We first show that, as expected, the generalized cable equation and the standard cable generate magnetic fields that mostly depend on the axial current in the cable, with a moderate contribution of extracellular currents. Less expected, we also show that the nature of the extracellular and intracellular media influence the axial current, and thus also influence neuronal magnetic fields. We illustrate these properties by numerical simulations and suggest experiments to test these findings.
UNIC, CNRS, F-91198 Gif-sur-Yvette, France.
Claude
C
Bedard
UNIC, CNRS, F-91198 Gif-sur-Yvette, France.
Alain
A
Destexhe
D003198:Computer Simulation; D003712:Dendrites / Q000502:physiology; D004560:Electricity; D005110:Extracellular Space / Q000502:physiology; D060526:Magnetic Fields; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology