[Particularities of γ-aminobutyric acid metabolism in the liver of rats during different types of alcohol withdrawal].
Activities of GABA-catabolising enzymes and the contents of some amino acids have been studied in the liver of the rats with different types of alcohol cessation after its systemic administration. Intermittent alcohol intoxication was accompanied by activation of liver GABA catabolism in case of the lowest alcohol load. However ethanol in higher doses and prolongation of intermittent alcohol administration decreased GABA catabolism. It is suggested that the observed changes may reflect non-specific adaptation of hepatocytes to the excessive alcohol consumption and its further cessation.
V V
VV
Lelevich
A G
AG
Vinitskaya
S V
SV
Lelevich
Ye M
YM
Doroshenko
D000222:Adaptation, Physiological; D000435:Alcoholic Intoxication / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000431:Ethanol; D005680:gamma-Aminobutyric Acid
GABA catabolism; amino acids; ethanol; g-aminobutyric acid (GABA); liver