Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice.
Molecular Imaging Laboratory, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Building 75, Charlestown, Massachusetts 02129, USA. cran@nmr.mgh.harvard.edu amoore@helix.mgh.harvard.edu.
Yanli
Y
Tian
Xueli
X
Zhang
Yuyan
Y
Li
Timothy M
TM
Shoup
Xin
X
Teng
David R
DR
Elmaleh
Anna
A
Moore
Chongzhao
C
Ran
D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000814:Aniline Compounds / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D043844:Crown Ethers / Q000737:chemistry* / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D008024:Ligands; D051379:Mice; D018613:Microscopy, Confocal; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism; D013844:Thiazoles / Q000737:chemistry / Q000378:metabolism
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D043844:Crown Ethers; D008024:Ligands; D010446:Peptide Fragments; D013844:Thiazoles; C078592:amyloid beta-protein (1-40); C557123:12-crown-4