Control systems and coordination protocols of the secretory pathway.
Like other cellular modules, the secretory pathway and the Golgi complex are likely to be supervised by control systems that support homeostasis and optimal functionality under all conditions, including external and internal perturbations. Moreover, the secretory apparatus must be functionally connected with other cellular modules, such as energy metabolism and protein degradation, via specific rules of interaction, or "coordination protocols". These regulatory devices are of fundamental importance for optimal function; however, they are generally "hidden" at steady state. The molecular components and the architecture of the control systems and coordination protocols of the secretory pathway are beginning to emerge through studies based on the use of controlled transport-specific perturbations aimed specifically at the detection and analysis of these internal regulatory devices.
Consiglio Nazionale delle Ricerche (CNR), Istituto di Biochimica delle Proteine (IBP) Via Pietro Castellino 111, 80131 Napoli Italy ; Telethon Institute of Genetics and Medicine (TIGEM) Via Pietro Castellino 111, 80131 Napoli Italy.
Alberto
A
Luini
Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti, Consiglio Nazionale delle Ricerche Viale Manzoni 30, 00185 Roma Italy.
Gabriella
G
Mavelli
Istituto di Ricovero e Cura a Carattere Scientifico-SDN 80143 Napoli Italy.
Juan
J
Jung
Consiglio Nazionale delle Ricerche (CNR), Istituto di Biochimica delle Proteine (IBP) Via Pietro Castellino 111, 80131 Napoli Italy ; Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andrés Bello Quillota 980, 2520000 Viña del Mar Chile.
Jorge
J
Cancino