Outside in: inversion of cell polarity controls epithelial lumen formation.
Establishment of cell polarity is important for epithelial lumen formation, and the molecular mechanisms directing this process are only partially understood. In this issue of Developmental Cell, Bryant et al. (2014) show that disassembly, membrane translocation, and reassembly of podocalyxin complexes controls epithelial cell polarization and lumen formation in 3D matrices.
Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, MO 65212, USA. Electronic address: davisgeo@health.missouri.edu.
George E
GE
Davis
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ondine B
OB
Cleaver
D000818:Animals; D016764:Cell Polarity / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D009024:Morphogenesis; D038081:Organogenesis