Langerhans cells proliferation in ectopic micronodular thymoma with lymphoid stroma: a case report.
Ectopic micronodular thymoma (MNT) is a rare tumor. We described a 76-year-old woman, who was referred to our institutional for a mass in the left cervical region. The Magnetic Resonance Imaging (MRI) scan showed a 3.7 cm × 1.7 cm × 2.0 cm mass. The neoplasm was composed of epithelial tumor cells arranged in a micronodular growth pattern set in a stroma showing lymphoid hyperplasia with germinal centers. Immunohistochemical studies showed that the neoplastic epithelial cells were reactive for AE1/AE3, CK5/6, P63, and the lymphoid component to be of mixed B- and immature T-cell lineage. Langerhans cells were confirmed within epithelial nodules for the first time with langerin, S-100, CD1a expression. We report a case of cervical ectopic MNT to emphasize the langerhans cells proliferation and the histopathologic features and differential diagnosis of the rare lesion to promote a better and broader understanding of this less understood subject.
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.
Pengcheng
P
Zhu
Department of Oncology, Zhongshan Hospital of Hubei Province Wuhan 430000, China.
Fei
F
Yan
Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, China.
Qilin
Q
Ao
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D049109:Cell Proliferation; D002828:Choristoma / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D011237:Predictive Value of Tests; D017154:Stromal Cells / Q000737:chemistry / Q000276:immunology / Q000473:pathology*; D013945:Thymoma / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D047368:Tumor Burden
D014408:Biomarkers, Tumor
Thymoma; ectopic; langerhans cell; micronodular