Blood in a dish: In vitro synthesis of red blood cells.
Red blood cells, currently obtained from donors, represent the most common form of cell-based therapy. A better understanding of normal erythropoiesis is leading to improved multi-step protocols for the in vitro generation of fully mature red cells. The extensive in vitro expansion of embryonic erythroblasts and development of erythroid precursors as a potential transfusion product may help to deal with issues of scale and eventually find a place in the treatment of patients with acute and chronic anemias.
Tisch Cancer Center, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1079, New York, N.Y. 10029, Tel: (212) 241-6974, , annarita.migliaccio@mssm.edu.
Anna Rita
AR
Migliaccio
Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave., Rochester, N.Y. 14642, Tel: (585) 275-5098, , james_palis@urmc.rochester.edu.
James
J
Palis