Profiling serotonin reuptake inhibitors (SSRIs) in the environment: trends in analytical methodologies.
Selective serotonin reuptake inhibitor (SSRI) antidepressants are among the most prescribed pharmaceuticals worldwide and are ubiquitous in different areas of the environment. There are few reliable and specific analytical methods for the detection and quantification of SSRIs in environmental samples. The majority of the reported methods generally involve cleanup procedures that usually employ solid-phase extraction (SPE) followed by liquid chromatography with tandem mass spectrometry detection (LC-MS-MS). Herewith, a comprehensive overview of the described analytical methods available for the determination of SSRIs in environmental samples is provided. We address all steps involved in the analytical procedures, with the inherent advantages and disadvantages of each discussed.
a Group of Health Surveillance, Center of Pharmaceutical Studies, Faculty of Pharmacy , University of Coimbra , Coimbra , Portugal.
Liliana J G
LJ
Silva
Leonor M
LM
Meisel
Celeste M
CM
Lino
Angelina
A
Pena
D000928:Antidepressive Agents / Q000032:analysis* / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods; D004784:Environmental Monitoring / Q000379:methods; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis* / Q000737:chemistry
D000928:Antidepressive Agents; D004785:Environmental Pollutants; D017367:Selective Serotonin Reuptake Inhibitors
Analytical methodologies; antidepressants; environmental monitoring; selective serotonin re-uptake inhibitors