[Moebius syndrome and narcolepsy].
BACKGROUND
Moebius syndrome is a rare neurological disease that has a frequent association with parasomnia.


METHODS
We report on a patient with Moebius syndrome and the clinical presentation of a narcolepsy cataplexy syndrome. With the hypoplasia of the brainstem in the cranial magnetic resonance imaging, we were able to show the morphological correlate of Moebius syndrome. Comorbidity was detected by cognitive tests, polysomnography and detection of hypocretin in the cerebrospinal fluid. Despite normal sleep onset latency and only one episode of sleep onset rapid eye movement (REM) in the multiple sleep latency test, where expressiveness is significantly reduced in cases of paralysis of horizontal eye movement, the diagnosis of parasomnia with narcolepsy cataplexy symptoms could be made.


CONCLUSIONS
The hypocretin level of 132 pg/ml measured in the cerebro spinal fluid is compatible with this diagnosis and shows the relevance of a detailed diagnostic of parasomnia in patients with Moebius syndrome.
Neurologische Klinik des Diakoniekrankenhauses Friederikenstift, Humboldtstr. 5, 30169, Hannover, Deutschland, stefan_kraemer87@me.com.
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Krämer
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Goldammer
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Sindern
D000293:Adolescent; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020331:Mobius Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D009290:Narcolepsy / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D017286:Polysomnography / Q000379:methods*
D015415:Biomarkers; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins