The link between Parkinson's disease and breast and prostate cancers: A meta-analysis.
OBJECTIVE
Clinical observations have shown an increased morbidity for breast cancer or prostate cancer in patients with Parkinson's disease (PD), however, other reports have noted contradictory results. This pooled analysis was utilized to test whether PD is associated with the risk of breast or prostate cancer.


METHODS
We searched PubMed, Embase and Cochrane library and conducted a meta-analysis to clarify the correlation of PD with breast and/or prostate cancer risk. We identified 16 eligible articles from which odds ratios with 95% confident intervals were assessed as main measures in the pooled estimation. Subgroup analyses and cumulative meta-analysis were also performed.


RESULTS
Our results showed no PD risk associated with breast or prostate cancer in the overall population, which was supported by the results of cumulative meta-analyses. The subgroup analyses suggested no significant risk of breast or prostate cancer in patients with PD within relevant subsets, i.e. gender, ethnicity, PD diagnosis time or study design. No evidence of publication bias was observed across the involved studies.


CONCLUSIONS
This meta-analysis indicates a lack of association between PD and risk of breast or prostate cancer.
a Department of Pharmacology , University of Tennessee Health Science Center , Memphis , TN , USA.
Tengfei
T
Wang
D001943:Breast Neoplasms / Q000453:epidemiology*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000453:epidemiology*
Parkinson’s disease; breast cancer; meta-analysis; prostate cancer