Dihydroxanthenones from the fermentation product of an endophytic fungus Gliomastix murorum.
Three new dihydroxanthones, muroxanthenones A-C (1-3), together with three known dihydroxanthones (4-6) were isolated from the fermentation products of an endophytic fungus Gliomastix murorum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compound 3 showed high cytotoxicities against NB4 and PC3 cell with IC(50) values of 2.2 and 2.8 μM. The other compounds also showed moderate cytotoxicities for some tested cell lines with IC(50) values between 4.1 and 9.5 μM.
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities , Kunming 650031 , China.
Hai-Ying
HY
Yang
De-Yun
DY
Niu
Lu
L
Wang
Su-Juan
SJ
Wang
Cheng-Ming
CM
Zhang
Xue-Mei
XM
Gao
Gang
G
Du
Qiu-Fen
QF
Hu
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005285:Fermentation; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D044004:Xanthones; C000598730:muroxanthenone A; C000598731:muroxanthenone B; C000598733:muroxanthenone C
Gliomastix murorum; cytotoxicity; dihydroxanthenone; structure elucidation