Development and characterization of novel site specific hollow floating microspheres bearing 5-Fu for stomach targeting.
Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM). The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF) at pH 1.2. The yield of microspheres was obtained up to 84.46 ± 6.47%. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from 158.65 ± 12.02 to 198.67 ± 17.45 μm. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches.
Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India.
Peeyush
P
Bhardwaj
NKBR College of Pharmacy & Research Centre, Meerut, Uttar Pradesh, India.
Deepti
0000-0002-9773-3942
D
Chaurasia
Government College of Pharmacy, Rohru, Shimla, Himachal Pradesh, India.
Ranjit
R
Singh
Jagran Lakecity University, Bhopal, Madhya Pradesh, India.
Anoop
A
Swarup
D001682:Biological Availability; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008863:Microspheres; D010316:Particle Size; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D005472:Fluorouracil