Agouti-related protein neuron circuits that regulate appetite.
New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior. Distinct axon projections of this neuron population point to different circuits that regulate long-term appetite, short-term feeding, or visceral malaise-mediated anorexia. Here, we review recent studies examining these neural circuits that control food intake.
Janelia Research Campus, HHMI, Ashburn, Va., USA.
Scott M
SM
Sternson
Deniz
D
Atasoy
D054369:Agouti-Related Protein / Q000378:metabolism; D000818:Animals; D000855:Anorexia / Q000503:physiopathology; D001069:Appetite Regulation / Q000502:physiology*; D001070:Appetitive Behavior / Q000502:physiology; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology
D054369:Agouti-Related Protein