Complement--tapping into new sites and effector systems.
Complement is traditionally known to be a system of serum proteins that provide protection against pathogens through direct cell lysis and the mobilization of innate and adaptive immunity. However, recent work indicates that the complement system has additional physiological roles beyond those in host defence. In this Opinion article, we describe the new modes and locations of complement activation that enable it to interact with other cell effector systems, such as growth factor receptors, inflammasomes and metabolic pathways. We propose that the location of complement activation dictates its function.
1] Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London SE1 9RT, UK. [2].
Martin
M
Kolev
1] Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London SE1 9RT, UK. [2].
Gaelle
G
Le Friec
Division of Transplant Immunology and Mucosal Biology, MRC Centre for Transplantation, King's College London, Faculty of Life Sciences and Medicine, Guy's Hospital, London SE1 9RT, UK.
Claudia
C
Kemper
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003167:Complement Activation / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology; D051379:Mice; D011951:Receptors, Complement / Q000276:immunology*; D017978:Receptors, Growth Factor / Q000276:immunology; D051880:Receptors, Notch / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D058847:Inflammasomes; D011951:Receptors, Complement; D017978:Receptors, Growth Factor; D051880:Receptors, Notch; D003165:Complement System Proteins