Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts.
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Pharmacology and Experimental Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Elizabeth A
EA
Griffiths
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Michelle C
MC
Golding
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Pragya
P
Srivastava
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Benjamin J
BJ
Povinelli
Department of Pharmacology and Experimental Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, USA.
Smitha R
SR
James
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Laurie A
LA
Ford
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Meir
M
Wetzler
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.
Eunice S
ES
Wang
Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA Michael.Nemeth@RoswellPark.org Elizabeth.Griffiths@RoswellPark.org.
Michael J
MJ
Nemeth
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001752:Blast Crisis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects*; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D054852:Small Molecule Libraries / Q000494:pharmacology*; D051176:beta Catenin / Q000037:antagonists & inhibitors*
D054852:Small Molecule Libraries; D051176:beta Catenin
WNT inhibitors; WNT signaling; acute myeloid leukemia; β-catenin