Practical utility of insulin-like growth factor II mRNA-binding protein 3, glucose transporter 1, and epithelial membrane antigen for distinguishing malignant mesotheliomas from benign mesothelial proliferations.
The differentiation of malignant mesotheliomas and benign mesothelial proliferations is crucial in determining patient care and prognosis. But, this distinction can be extremely difficult, particularly in small biopsies. Recently, insulin-like growth factor II mRNA-binding protein 3 (IMP3) and glucose transporter 1 (GLUT-1) have been reported as specific and sensitive markers in the distinction of mesotheliomas from benign mesothelial proliferations. The purpose of this study is to evaluate the utility of IMP3, GLUT-1, and epithelial membrane antigen (EMA) immunohistochemistry for distinguishing mesotheliomas from benign mesothelial proliferations. Immunoexpression of IMP3, GLUT-1, and EMA was evaluated in 88 malignant mesotheliomas, 35 adenomatoid tumors, and 20 benign lung tissues with reactive mesothelial cells. The sensitivity for IMP3, GLUT-1, and EMA was 37%, 21%, and 41%, respectively. The specificity for IMP3, GLUT-1, and EMA was 100%. When IMP3, GLUT1, and EMA combined, the sensitivity was 66% for IMP3/EMA staining, 53% for GLUT-1/EMA staining, and 45% for IMP3/GLUT-1. Use of IMP3 and EMA together is more helpful to distinguish malignant mesotheliomas from benign mesothelial proliferations than the use of IMP3 or EMA alone.
Department of Pathology, Inje University Ilsan Paik Hospital, Goyang, Republic of Korea.
Sunhee
S
Chang
Mee-Hye
MH
Oh
Sun-Young
SY
Ji
Joungho
J
Han
Tae-Jung
TJ
Kim
Minseob
M
Eom
Kun Young
KY
Kwon
Seung Yeon
SY
Ha
Yoo Duk
YD
Choi
Chang Hun
CH
Lee
Yonghee
Y
Lee
Soon-Hee
SH
Jung
D014408:Biomarkers, Tumor / Q000032:analysis*; D049109:Cell Proliferation; D004848:Epithelium / Q000473:pathology; D051272:Glucose Transporter Type 1 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008654:Mesothelioma / Q000175:diagnosis*; D018396:Mucin-1 / Q000032:analysis / Q000096:biosynthesis*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D012680:Sensitivity and Specificity; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; D051272:Glucose Transporter Type 1; C498780:IGF2BP3 protein, human; D018396:Mucin-1; D016601:RNA-Binding Proteins
epithelial membrane antigen; glucose transporter type 1; immunohistochemistry; insulin-like growth factor II mRNA-binding protein 3; mesothelioma