Iron- and cobalt-catalyzed arylation of azetidines, pyrrolidines, and piperidines with Grignard reagents.
Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Baptiste
B
Barré
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Laurine
L
Gonnard
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Rémy
R
Campagne
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Sébastien
S
Reymond
‡NovAliX, BioParc, 850 Bld Sébastien Brant, BP 30170, F-67405 Illkirch, Cedex, France.
Julien
J
Marin
‡NovAliX, BioParc, 850 Bld Sébastien Brant, BP 30170, F-67405 Illkirch, Cedex, France.
Paola
P
Ciapetti
‡NovAliX, BioParc, 850 Bld Sébastien Brant, BP 30170, F-67405 Illkirch, Cedex, France.
Marie
M
Brellier
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Amandine
A
Guérinot
†Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI)-UMR 8231 ESPCI ParisTech, CNRS, PSL Research University, 10, Rue Vauquelin 75231 Paris Cedex 05, France.
Janine
J
Cossy
D001384:Azetidines / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*
D001384:Azetidines; D007202:Indicators and Reagents; D010880:Piperidines; D011759:Pyrrolidines; D003035:Cobalt; D007501:Iron