AdipoQ T45 G and G276 T Polymorphisms and Susceptibility to Nonalcoholic Fatty Liver Disease Among Asian Populations: A Meta-Analysis and Meta-Regression.
BACKGROUND
Adiponectin (AdipoQ) is an adipose-derived plasma protein that plays an important role in hepatic lipoprotein-lipid metabolism. Emerging evidence have shown that two common polymorphisms (T45 G and G276 T) in the AdipoQ gene may contribute to increasing susceptibility to nonalcoholic fatty liver disease (NAFLD); however individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association of AdipoQ T45 G (rs2241766 T>G) and G276 T (rs1501299 G>T) polymorphisms with NAFLD risk.


METHODS
Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, the Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), Chinese Bio-medicine Database (CBM), and Chinese Sci-tech Journals databases. Statistical analyses were calculated using the version 12.0 STATA software (Stata Corp, College Station, TX, USA). Odds ratios (ORs) and its corresponding 95% confidence interval (CI) were calculated.


RESULTS
Ten case-control studies were included with a total of 2,672 subjects, of these 1,117 being NAFLD patients and 1,555 being healthy controls. Our meta-analysis results revealed that the T variant of AdipoQ rs2241766 T>G polymorphism may be associated with an increased risk of NAFLD. There was also a significant association between the G variant of AdipoQ rs1501299 G>T polymorphism and an increased risk of NAFLD. Country-stratified analysis indicated that a higher AdipoQ rs2241766 T>G polymorphism was closely related with an increased risk of NAFLD in Chinese and Indian populations (all Ps < 0.05); a similar result was observed in Chinese populations between AdipoQ rs2241766 T>G polymorphism and an increased risk of NAFLD (P < 0.05).


CONCLUSIONS
In conclusion, the current meta-analysis indicates that AdipoQ rs2241766 T>G and rs1501299 G>T polymorphisms may contribute to an increasing susceptibility to NAFLD. Moreover, this meta-analysis also suggests for future larger studies with stratified case-control population, and greater focus on the gene-environment interactions regarding NAFLD susceptibility for valid studies.
Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Bai-Fang
BF
Wang
Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Ying
Y
Wang
Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Ran
R
Ao
Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Jing
J
Tong
Department of Elderly Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Bing-Yuan
BY
Wang
D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D019992:Databases as Topic; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D008957:Models, Genetic; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis
C499918:ADIPOQ protein, human; D052242:Adiponectin
adiponectin; meta-analysis; meta-regression; nonalcoholic fatty liver disease; single-nucleotide polymorphism