Congenital anomaly of the inferior vena cava and factor V Leiden mutation predisposing to deep vein thrombosis.
A previously healthy 21-year-old man presented with back pain, bilateral extremity pain, and right lower extremity weakness, paresthesias, and swelling. Sonographic examination revealed diffuse deep vein thrombosis (DVT) in the femoral and popliteal venous system. CT imaging revealed hypoplasia of the hepatic inferior vena cava (IVC) segment with formation of multiple varices and collateral veins around the kidneys. Hematologic workup also discovered a factor V Leiden mutation, further predisposing the patient to DVT. The rare, often overlooked occurrence of attenuated IVC, especially in the setting of hypercoagulable state, can predispose patients to significant thrombosis.
St George's University, Grenada, West Indies.
Brooke M
BM
Lamparello
Northeast Ohio Medical University, Rootstown, OH, USA.
Cameron R
CR
Erickson
Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA.
Arun
A
Kulthia
Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA.
Vasudev
V
Virparia
Department of Medicine, Coney Island Hospital, Brooklyn, NY, USA.
Zeyar
Z
Thet
D020016:Activated Protein C Resistance / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D000925:Anticoagulants / Q000627:therapeutic use; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009154:Mutation; D010690:Phlebography / Q000379:methods; D011237:Predictive Value of Tests; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography; D054079:Vascular Malformations / Q000150:complications* / Q000175:diagnosis; D014682:Vena Cava, Inferior / Q000002:abnormalities* / Q000000981:diagnostic imaging; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000235:genetics; D055815:Young Adult
D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V
deep vein thrombosis (DVT); inferior vena cava (IVC); lower extremities; thrombophilic; venography