Changes to circulating inflammatory cytokines in response to moderate exercise.
BACKGROUND
Regular physical activity improves the metabolic profile of patients, although the biological mechanisms involved are not clear yet. The anti-inflammatory effects of exercise are well known and are possibly related to its therapeutic properties. The aim of this study was to compare changes in the concentration of an anti-inflammatory cytokine - tumor necrosis factor soluble receptor-1 (sTNFR1) - and a pro-inflammatory cytokine - interleukin-1β (IL-1β) - during moderate physical exercise in sedentary versus athletic men.


METHODS
We analyzed serum inflammatory cytokine concentrations in 5 athletes and 5 sedentary men (aged 18 to 22): 1) 15 minutes and immediately before a 28-minute specifically-programmed moderate exercise session; 2) every 3 minutes during the exercise session; 3) 15 and 30 minutes after session completion.


RESULTS
We obtained serum sTNFR1 and IL-1β concentrations in 10 individuals. Both cytokines exhibited changes in their concentration during physical exercise: a significant increase in the concentration of sTNFR1 was observed in both the sedentary (P=0.0249) and the athlete (P=0.02172) groups. The levels of sTNFR1 were higher in the athlete group than in the sedentary group. No differences were observed in the IL-1β concentrations between the two groups.


CONCLUSIONS
Serum concentration of the anti-inflammatory cytokine sTNFR1 increased during moderate physical exercise, and its levels were higher in athletes before, during and after physical activity. These findings are consistent with previous findings concerning the anti-inflammatory properties of exercise, and suggest that sTNFR1 has an important role in the anti-inflammatory environment following physical activity.
Lipids and Diabetes Laboratory, Department of Physiological Sciences, Faculty of Medicine, National University of Colombia, Bogotá, Colombia - ngomezb@unal.edu.co.
Nicolás
N
Gómez-Banoy
Ismena
I
Mockus
Luz H
LH
Aranzález
Juan M
JM
Zambrano
D000293:Adolescent; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D010809:Physical Fitness / Q000502:physiology*; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D057185:Sedentary Behavior; D055815:Young Adult
D053583:Interleukin-1beta; D047888:Receptors, Tumor Necrosis Factor, Type I