Human mast cell and basophil/eosinophil progenitors.
Mast cell, basophil, and eosinophil lineages all derive from CD34(+) hemopoietic stem cells; however, mast cells are derived from a distinct, nonmyeloid progenitor, while eosinophils and basophils share a common myeloid progenitor. These progenitors likely evolved from an ancestral leukocyte population involved in innate immunity and currently play a central role in the pathology of allergic disease. Advances in isolation and analysis of mast cell and basophil/eosinophil progenitor populations have been critical to understanding lineage commitment, differentiation, function, and transcriptional regulation of these cells and have provided a way of monitoring the effect of novel investigational therapies on these cell populations in samples of blood, bone marrow, and airway secretions.
McMaster University, HSC-3U26, 1280 Main Street West, Hamilton, ON, Canada, L8S 4K1, gauvreau@mcmaster.ca.
Gail M
GM
Gauvreau
Judah A
JA
Denburg
D001491:Basophils / Q000166:cytology*; D001854:Bone Marrow Cells / Q000166:cytology; D004804:Eosinophils / Q000166:cytology*; D005312:Fetal Blood / Q000166:cytology; D005434:Flow Cytometry; D006801:Humans; D008407:Mast Cells / Q000166:cytology*; D008747:Methylcellulose / Q000737:chemistry; D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism; D016185:Receptors, Interleukin-3 / Q000378:metabolism; D053649:Receptors, Interleukin-5 / Q000378:metabolism; D013183:Sputum / Q000276:immunology; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism
D016187:Receptors, Granulocyte-Macrophage Colony-Stimulating Factor; D016185:Receptors, Interleukin-3; D053649:Receptors, Interleukin-5; D008747:Methylcellulose