Effect of route of preoperative biopsy on endoscopic submucosal dissection for patients with early gastric cancer.
OBJECTIVE
To observe and compare the effects of multi-patch biopsy under conventional white light imaging endoscopy (C-WLI) and precise targeted biopsy under magnifying narrow-band imaging endoscopy (M-NBI) on the endoscopic submucosal dissection (ESD) of early gastric cancers and intraepithelial neoplasias.


METHODS
According to the way of selecting biopsy specimens, patients were divided into C-WLI and M-NBI groups, 20 cases. The ESD operations of the 2 groups were compared quantitively.


RESULTS
The mean frequency of biopsy in M-NBI group was (1.00±0.00), obviously lower than in the C-WLI group (4.78±1.02) (P<0.01).The average total number of selected biopsy specimens was also fewer (1.45±0.12 and 7.82±2.22, respectively, P<0.01). There was no significant difference in the time of determining excision extension, marking time and the time of specimen excision of 2 groups during the ESD (P>0.05), whereas submucosal injection time, mucosal dissection time, stopping bleeding time, wound processing time in the M-NBI group were significantly shorter than in the C-WLI group (P<0.01).


CONCLUSIONS
Precise targeted biopsy under M-NBI can obviously shorten the time of ESD operation, with small quantity of tissues but high pathological positive rate.
Department of General Surgery, Jiangsu University Hospital, Wuxi, Jiangsu, China E-mail : thmercpthmercp @163.com.
Hui
H
Jiang
Hui-Ming
HM
Tu
Qiao
Q
Qiao
Ke-Bin
KB
Xu
Jie
J
Li
Xiao-Wei
XW
Qi
Xiao-Song
XS
Ge
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D001706:Biopsy; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D016022:Case-Control Studies; D004210:Dissection; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D062048:Narrow Band Imaging; D009367:Neoplasm Staging; D011300:Preoperative Care; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*