Autologous stem cell transplantation in HIV-related lymphoma in the rituximab era - a feasibility study in a monocentric cohort.
BACKGROUND
Since the introduction of highly active antiretroviral therapy (HAART) (1) and later on the availability of anti-CD20 monoclonal antibody treatment (2), the therapeutic options as well as the prognosis of AIDS related lymphoma (ARL) have been improved. There is however no uniform agreement on how to treat patients who do not achieve a partial remission, who experience a relapse or who have very aggressive subtypes. Autologous hematopoietic stem cell transplantation (ASCT) has become an option for those patients. We retrospectively examined ARL patients to elucidate the feasibility of high-dose chemotherapy and autologous stem cell transplantation.


METHODS
Data of seven male and one female HIV+ patients with ARL was collected and informed consent was obtained. Age, HIV disease characteristics (CD4 count, HIV-RNA-PCR, ART) and transplantation-related details (histopathology, myeloablative therapy, neutrophil engraftment and NCI-CTCAE during/after transplantation as well as follow up and survival) were obtained from the patients' medical records.


RESULTS
Eight patients were treated with the intent of ASCT. The median age was at 64 years. Four patients had experienced prior AIDS. The median CD4 NADIR was at 157/µl, the median CD4 count at diagnosis of lymphoma at 81/µl. Five patients were receiving combination antiretroviral therapy (cART) at the time of lymphoma diagnosis, four of which had achieved a viral load of less than 50/µl. Two patients have died, due to (Nr. 8) a transplant-related complication (non-infectious leukoencephalophathy). The other patient died of an unknown reason (351 days after transplantation). The median survival is at 345 days to date. The time until engraftment was well at 11 days. Grade 3/4 haematological toxicity was present in all patients. Five out of three patients developed infectious complications, but there were no infection-related deaths. One patients (Nr. 4) developed a Kaposi Sarcoma reactivation that necessitated further chemotherapy.


CONCLUSIONS
ASCT is feasible in high risk ARL with good engraftment. Toxicity was substantial and studies are needed to define which patients have an unduly high risk of toxicity.
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Imke
I
Wieters
Haematology and Oncology, J. W. Goethe University Hospital, Frankfurt, Germany.
Johannes
J
Atta
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Gerrit
G
Kann
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Junaid
J
Owasil
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Siri
S
Goepel
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Annette
A
Haberl
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Christoph
C
Stephan
Department of Infectious Diseases, HIV Center, J. W. Goethe University Hospital, Frankfurt, Germany.
Timo
T
Wolf