Dysregulation of JAM-A plays an important role in human tumor progression.
Junctional adhesion molecule A (JAM-A) is a transmembrane protein that belongs to the immunoglobulin (Ig) superfamily. Evidence determines that JAM-A plays a role in numerous cellular processes, including tight junction assembly, leukocyte migration, platelet activation, angiogenesis and virus binding. Recent research suggests that JAM-A is dysregulated in various cancers and is vital for tumor progression. JAM-A is implicated in carcinogenesis via different signal pathways such as TGF-β1 signaling. Furthermore, JAM-A expression in cancers is usually associated with certain outcome of patients and might be a prognostic indicator. In this review, the correlation between JAM-A expression and human cancers will be described.
Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Chen
C
Zhao
Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Funian
F
Lu
Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Hongxia
H
Chen
Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Xianda
X
Zhao
Department of Pathology, Maternal and Child Health Hospital of Hubei Province Wuhan 430072, P. R. China.
Jun
J
Sun
Department of Pathology, School of Basic Medical Science, Wuhan University Wuhan 430071, P. R. China.
Honglei
H
Chen
D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D019108:Tight Junctions / Q000378:metabolism* / Q000473:pathology
D015815:Cell Adhesion Molecules; C407243:F11R protein, human; D011956:Receptors, Cell Surface
Tight junction; junctional adhesion molecule-A; tumor progression