Lipid-based patterning of the immunological synapse.
The immunological synapse controls T-lymphocyte function by polarizing effector responses towards the antigen-presenting cell. In this review, I discuss the molecular pathways required for synapse assembly, focusing on the central roles played by lipid second-messenger signalling.
*Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, U.S.A.
Morgan
M
Huse
D006801:Humans; D054992:Immunological Synapses; D008055:Lipids / Q000737:chemistry*; D015290:Second Messenger Systems; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D008055:Lipids