[The ciliary pocket: a rendezvous between the centrosome and vesicular trafficking].
The assembly of cilia, ciliogenesis, involves complex and conserved mechanisms during which the basal body has to dock onto cell membranes. Studies in the 1960s suggested that in many cell types such docking occurs in the cytoplasm and that cilia are formed within a vesicle before being delivered to the plasma membrane. This intracellular pathway, recently characterized at the molecular level, leads to the formation of a membrane domain at the basis of cilia, the ciliary pocket, which was involved in vesicular trafficking and signaling.
Inserm UMR 1163, laboratoire des maladies rénales héréditaires, Paris, France - Université Paris Descartes-Sorbonne Paris Cité, institut Imagine, 24, boulevard du Montparnasse, 75015 Paris, France.
Alexandre
A
Benmerah
D000818:Animals; D054468:Axoneme / Q000502:physiology / Q000648:ultrastructure; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D002502:Centrioles / Q000502:physiology / Q000648:ultrastructure; D018385:Centrosome / Q000502:physiology / Q000648:ultrastructure*; D002923:Cilia / Q000502:physiology / Q000648:ultrastructure*; D005057:Eukaryotic Cells; D006801:Humans; D008954:Models, Biological; D062105:Molecular Docking Simulation; D020409:Molecular Motor Proteins / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000502:physiology
D020409:Molecular Motor Proteins; D043562:Receptors, G-Protein-Coupled; D020691:rab GTP-Binding Proteins