Case report: postradiation chondrosarcoma with a short latency period of 6 months.
We describe a case of postradiation chondrosarcoma after basal cell carcinoma treatment. At the time he presented, the patient was a 35-year-old man who had received radiotherapy at a dose of 70 Gy for 8 weeks. Six months after radiation treatment, a rapidly growing mass at the upper right alveolar ridge of the gums, where radiation had been given, was diagnosed as chondrosarcoma. Generally, chondrosarcoma occurs after a latency period of several years following radiation. However, there are a few relevant reports indicating that maxillofacial chondrosarcoma can develop after radiotherapy for basal cell carcinoma, with a short latency of 6 months. We hypothesize that the dosage and treatment time of radiation may have played a role in the opening/closing of the Hh-signaling pathway in the case of this patient.
3 Department of Oral and Maxillofacial Surgery, West China School of Stomatology, Sichuan University, Chengdu - China.
Sen
S
Yang
Wei
W
Tang
Xiu-fa
XF
Tang
Ming
M
Xuan
Li-juan
LJ
Guo
Xiao-Yi
XY
Wang
Wings T Y
WT
Loo
Qing
Q
Liu
Louis W C
LW
Chow
Mary N B
MN
Cheung
William
W
Tsang
D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology* / Q000601:surgery; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000532:radiotherapy; D002813:Chondrosarcoma / Q000473:pathology* / Q000601:surgery; D005147:Facial Bones / Q000473:pathology* / Q000528:radiation effects; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery