Role of innate immunity in pregnant patients with vulvovaginal infections in the development of intrauterine infection in the newborn.
A total of 115 pregnant women were examined: 59 patients with opportunistic vulvovaginal infections and 56 without infection. Congenital immunity parameters (TLR-2, NF-κB, and IL-2 receptors in placental tissue) were studied by immunohistochemical methods. Realization of congenital infection was associated with activation of IL-6 receptors and TLR-2 in the placenta and an increase of NF-κB level. These changes seemed to reflect the strained status of congenital immunity and were responsible for the intensity of local inflammatory response.
V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation, Moscow, Russia, v_tioutiounnik@oparina4.ru.
V L
VL
Tyutyunnik
N E
NE
Kan
N A
NA
Lomova
T E
TE
Karapetyan
E A
EA
Kogan
A I
AI
Shchyogolev
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002824:Chorionic Villi / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007231:Infant, Newborn; D016328:NF-kappa B / Q000378:metabolism; D010920:Placenta / Q000276:immunology / Q000378:metabolism; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D011256:Pregnancy Outcome; D019947:Receptors, Interleukin-6 / Q000378:metabolism; D051195:Toll-Like Receptor 2 / Q000378:metabolism; D014591:Uterine Diseases / Q000276:immunology* / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000276:immunology*; D055815:Young Adult
D016328:NF-kappa B; D019947:Receptors, Interleukin-6; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2