[Combination inositol and glucomannan in PCOS patients].
OBJECTIVE
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies of the reproductive age in women. PCOS is an endocrine-metabolic disorder characterized by insulin resistance. Aim of the study was to evaluate the efficacy of natural substances such as inositol and glucomannan, and their combination in reducing glucose levels and improving insulin sensitivity in PCOS patients.


METHODS
Forty women with clinical and endocrinological signs of PCOS were enrolled in the study and divided into three groups, including ten women each. The three groups were respectively treated with the combination inositol and glucomannan (A group), inositol (B group), glucomannan (C group) for a period of 3 months. Plasma levels of glucose and insulin were evaluated before and after treatment in our laboratory.


RESULTS
There was a reduction in blood glucose and insulin levels, with particular significance in the group treated with the combination of inositol-glucomannan.


CONCLUSIONS
Present results show that the association-inositol glucomannan may represent a good therapeutic strategy in the treatment of PCOS women with insulin resistance.
Centro di Sterilità di Coppia, Dipartimento di Medicina Molecolare e dello Sviluppo, Università degli Studi di Siena, Siena, Italia - vincenzo.deleo@unisi.it.
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Cianci
D000328:Adult; D001786:Blood Glucose / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007294:Inositol / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008351:Mannans / Q000008:administration & dosage / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin; D008351:Mannans; C022901:(1-6)-alpha-glucomannan; D007294:Inositol