Apolipoprotein e4 affects topographical changes in hippocampal and cortical atrophy in Alzheimer's disease dementia: a five-year longitudinal study.
Apolipoprotein E4 (APOE4) is a genetic risk factor for developing Alzheimer's disease (AD). Once AD manifests clinically, however, the effects of APOE4 are less clear. Therefore, we investigated the longitudinal effects of APOE4 on topographical changes in AD patient brain atrophy. We prospectively recruited 35 patients with AD (19 APOE4 carriers and 16 non-carriers), and 14 normal controls, then followed them for five years. We measured hippocampal deformities and cortical thickness. Hippocampal comparison between APOE4 carriers and non-carriers with AD showed carriers had rapid changes in the head and body, while non-carriers had rapid changes in a small portion of the body. Cortical thickness comparison between APOE4 carriers and non-carriers with AD dementia showed carriers had rapid thinning in the lateral frontal, temporal, and parietal regions, while no region showed more rapid cortical thinning in non-carriers than in carriers. These findings underlined the importance of the APOE4 allele for designing and interpreting future treatment trials in patients with AD dementia.
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea Neuto Science Center, Samsung Medical Center, Seoul, Republic of Korea.
Yeo Jin
YJ
Kim
Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Hanna
H
Cho
Department of Neurology, Ilsong Institute of Life Science, Hallym University, Anyang, Korea.
Yun Joong
YJ
Kim
Department of Laboratory Medicine & Genetics, Sungkyunkwan University School of Medicine, Seoul, Korea.
Chang-Seok
CS
Ki
Department of Neurology, Asan Medical Center, Ulsan University School of Medicine, Seoul, Korea.
Sun Ju
SJ
Chung
Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
Byoung Seok
BS
Ye
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea Neuto Science Center, Samsung Medical Center, Seoul, Republic of Korea.
Hee Jin
HJ
Kim
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jung-Hyun
JH
Kim
Department of Radiology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sung Tae
ST
Kim
Department of Nuclear Medicine and, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kyung Han
KH
Lee
Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
Seun
S
Jeon
Department of Biomedical Engineering, Hanyang University, Seoul, Korea.
Jong-Min
JM
Lee
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea Neuto Science Center, Samsung Medical Center, Seoul, Republic of Korea.
Juhee
J
Chin
Department of Computer and Radio Communications Engineering, Korea University, Seoul, Republic of Korea.
Jeong-Hun
JH
Kim
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea Neuto Science Center, Samsung Medical Center, Seoul, Republic of Korea.
Duk L
DL
Na
Department of Biomedical Engineering, Korea University, Seoul, Republic of Korea.
Joon-Kyung
JK
Seong
Department of Neurology, Sungkyunkwan University School of Medicine, Seoul, Korea Neuto Science Center, Samsung Medical Center, Seoul, Republic of Korea.
Sang Won
SW
Seo
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D000704:Analysis of Variance; D053327:Apolipoprotein E4; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D005838:Genotype; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests
D053327:Apolipoprotein E4
APOE4 allele; cortical thickness; dementia with Alzheimer's disease; hippocampal deformities; longitudinal study