Phylogeography of E1b1b1b-M81 haplogroup and analysis of its subclades in Morocco.
In this study we analyzed 295 unrelated Berber-speaking men from northern, central, and southern Morocco to characterize frequency of the E1b1b1b-M81 haplogroup and to refine the phylogeny of its subclades: E1b1b1b1-M107, E1b1b1b2-M183, and E1b1b1b2a-M165. For this purpose, we typed four biallelic polymorphisms: M81, M107, M183, and M165. A large majority of the Berber-speaking male lineages belonged to the Y-chromosomal E1b1b1b-M81 haplogroup. The frequency ranged from 79.1% to 98.5% in all localities sampled. E1b1b1b2-M183 was the most dominant subclade in our samples, ranging from 65.1% to 83.1%. In contrast, the E1b1b1b1-M107 and E1b1b1b2a-M165 subclades were not found in our samples. Our results suggest a predominance of the E1b1b1b-M81 haplogroup among Moroccan Berber-speaking males with a decreasing gradient from south to north. The most prevalent subclade in this haplogroup was E1b1b1b2-M183, for which diffferences among these three groups were statistically significant between central and southern groups.
Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Casablanca, Morocco.
Ahmed
A
Reguig
Equipe des sciences Anthropogénétiques et Biotechnologie, Département de Biologie, Faculté des Sciences El Jadida, Université Chouaib Eddoukkali, El Jadida, Morocco.
Nourdin
N
Harich
Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Casablanca, Morocco.
Abdelhamid
A
Barakat
Laboratoire de Génétique Moléculaire Humaine, Département de Recherche Scientifique, Institut Pasteur du Maroc, Casablanca, Morocco.
Hassan
H
Rouba
D000483:Alleles; D041322:Chromosomes, Human, Y; D004247:DNA / Q000097:blood / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D009018:Morocco; D010802:Phylogeny; D058974:Phylogeography / Q000379:methods; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
D004247:DNA