MatrixDB, the extracellular matrix interaction database: updated content, a new navigator and expanded functionalities.
MatrixDB (http://matrixdb.ibcp.fr) is a freely available database focused on interactions established by extracellular proteins and polysaccharides. It is an active member of the International Molecular Exchange (IMEx) consortium and has adopted the PSI-MI standards for annotating and exchanging interaction data, either at the MIMIx or IMEx level. MatrixDB content has been updated by curation and by importing extracellular interaction data from other IMEx databases. Other major changes include the creation of a new website and the development of a novel graphical navigator, iNavigator, to build and expand interaction networks. Filters may be applied to build sub-networks based on a list of biomolecules, a specified interaction detection method and/or an expression level by tissue, developmental stage, and health state (UniGene data). Any molecule of the network may be selected and its partners added to the network at any time. Networks may be exported under Cytoscape and tabular formats and as images, and may be saved for subsequent re-use.
UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France.
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Launay
UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France.
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Salza
UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France.
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Multedo
TIMC- IMAG/BCM, UMR 5525 CNRS - Université Grenoble 1, Faculté de Médecine, 38706 La Tronche Cedex, France.
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Thierry-Mieg
UMR 5086 CNRS - Université Lyon 1, 69367 Lyon Cedex 07, France s.ricard-blum@ibcp.fr.
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Ricard-Blum
D000818:Animals; D003196:Computer Graphics; D030562:Databases, Protein; D004285:Dogs; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D006801:Humans; D051379:Mice; D011134:Polysaccharides / Q000378:metabolism; D025941:Protein Interaction Mapping; D051381:Rats
D016326:Extracellular Matrix Proteins; D011134:Polysaccharides