The use of dexamethasone in support of high-altitude ground operations and physical performance: review of the literature.
OBJECTIVE
Military Special Operators (SOs) are exposed environmental conditions that can alter judgment and physical performance: uneven terrain, dryness of ambient air, reduction of air density, and a diminished partial pressure of oxygen. The primary purpose of this review was to determine the medical efficacy of dexamethasone as an intervention for the prevention and treatment of high-altitude illness. The secondary purpose was to determine its ability to maintain physical performance of SOs at high altitudes.


METHODS
A search of the literature from 1970 to 2014 was performed, locating 61 relevant articles, with 43 addressing the primary and secondary purposes of this literature review.


CONCLUSIONS
The review indicates that dexamethasone is an effective prevention and treatment intervention for high-altitude illness. Commonly used dosages of either 2 mg every 6 hours or 4 mg every 12 hours can prevent high-altitude illnesses in adults. Currently in USSOCOM operations, there is an option to use 4 mg every 6 hours (concurrently with acetazolamide 125 mg bid) if ascending rapidly to or above 11,500 ft without time for acclimatization. Researchers also determined that acute exposure to high altitude, even in asymptomatic subjects, resulted in small cognitive deficits that could be reversed with dexamethasone. Dexamethasone may also help improve cognition and maximal aerobic capacity in SOs who are susceptible to high-altitude pulmonary edema.
Reginald
R
O'Hara
Jennifer
J
Serres
William
W
Dodson
Wright
W
Bruce
Jason
J
Ordway
Eric
E
Powell
Molly
M
Wade
D000064:Acclimatization; D000086:Acetazolamide / Q000627:therapeutic use; D000531:Altitude; D000532:Altitude Sickness / Q000188:drug therapy / Q000517:prevention & control*; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D003071:Cognition; D003907:Dexamethasone / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D017079:Exercise Tolerance; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000517:prevention & control; D008889:Military Personnel
D002257:Carbonic Anhydrase Inhibitors; D005938:Glucocorticoids; D003907:Dexamethasone; D000086:Acetazolamide