Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.
METHODS
A reservoir intravaginal ring (IVR) eluting tenofovir disoproxil fumarate (TDF) was evaluated for 6 months of continuous use in normally cycling female pigtailed macaques with monthly IVR exchanges to define pharmacokinetics and safety.


CONCLUSIONS
Tenofovir levels in vaginal secretions and tissue remained consistent for 6 months with no adverse safety concerns.
Priya
P
Srinivasan
Chuong
C
Dinh
Jining
J
Zhang
Chou-Pong
CP
Pau
Janet M
JM
McNicholl
Yungtai
Y
Lo
Betsy C
BC
Herold
Ryan
R
Teller
Patrick
P
Kiser
James M
JM
Smith
D000225:Adenine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D000282:Administration, Intravaginal; D000818:Animals; D019380:Anti-HIV Agents / Q000493:pharmacokinetics*; D016503:Drug Delivery Systems; D005260:Female; D006678:HIV / Q000187:drug effects*; D016180:Lentivirus Infections / Q000517:prevention & control*; D008254:Macaca nemestrina; D063065:Organophosphonates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D000068698:Tenofovir; D013997:Time Factors; D014621:Vagina / Q000378:metabolism
D019380:Anti-HIV Agents; D063065:Organophosphonates; D000068698:Tenofovir; D000225:Adenine