Trans and interesterified fat and palm oil during the pregnancy and lactation period inhibit the central anorexigenic action of insulin in adult male rat offspring.
Palm oil and interesterified fat have been used to replace partially hydrogenated fats, rich in trans isomers, in processed foods. This study investigated whether the maternal consumption of normolipidic diets containing these lipids affects the insulin receptor and Akt/protein kinase B (PKB) contents in the hypothalamus and the hypophagic effect of centrally administered insulin in 3-month-old male offspring. At 90 days, the intracerebroventricular injection of insulin decreased 24-h feeding in control rats but not in the palm, interesterified or trans groups. The palm group exhibited increases in the insulin receptor content of 64 and 69 % compared to the control and trans groups, respectively. However, the quantifications of PKB did not differ significantly across groups. We conclude that the intake of trans fatty acid substitutes during the early perinatal period affects food intake regulation in response to centrally administered insulin in the young adult offspring; however, the underlying mechanisms remain unclear.
Laboratório de Bioquímica Nutricional, Instituto de Nutrição Josué de Castro da, Universidade Federal do Rio de Janeiro, Centro de Ciências da Saúde, Av. Carlos Chagas, 373, Edificio do Centro de Ciências da Saúde, Bloco J, 2º andar, sala 021, Rio de Janeiro, RJ, 219415-902, Brazil.
Kenia Pereira
KP
Bispo
Letícia
L
de Oliveira Rodrigues
Érica
É
da Silva Soares de Souza
Daniela
D
Mucci
Maria das Graças
Md
Tavares do Carmo
Kelse Tibau
KT
de Albuquerque
Fatima Lucia
FL
de Carvalho Sardinha
D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects* / Q000502:physiology*; D001426:Bacterial Proteins; D004041:Dietary Fats / Q000009:adverse effects*; D005227:Fatty Acids / Q000009:adverse effects; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D007276:Injections, Intraventricular; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D000073878:Palm Oil; D010938:Plant Oils / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D016601:RNA-Binding Proteins; D051381:Rats; D017208:Rats, Wistar; D011972:Receptor, Insulin / Q000378:metabolism; D044242:Trans Fatty Acids / Q000009:adverse effects
D001426:Bacterial Proteins; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D010938:Plant Oils; D016601:RNA-Binding Proteins; D044242:Trans Fatty Acids; C064872:antiterminator proteins, Bacteria; D000073878:Palm Oil; D011972:Receptor, Insulin