Time-domain algorithm for single-photon laser-Doppler flowmetry at large interoptode spacing in human bone.
A new laser-Doppler flowmeter at large interoptode spacing, based on single-photon counting (single-photon laser-Doppler flowmetry [SP-LDF]) and allowing assessment of blood flow deep in bone tissue, is proposed and implemented. To exploit the advantages of the new SP-LDF hardware, a dedicated simple and efficient time-domain algorithm has been developed. The new algorithm is based on the zero-order moment of the power density spectrum of the ad hoc prefiltered photoelectric current. The SP-LDF has been validated by Monte Carlo simulations, as well as by experimental measurements on a bone tissue phantom for optical flowmeters and on human.
Tiziano
T
Binzoni
Dimitri
D
Van De Ville
Bruno
B
Sanguinetti
D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D017078:Laser-Doppler Flowmetry / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D017785:Photons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013977:Tibia / Q000098:blood supply / Q000502:physiology*