Wip1 phosphatase in breast cancer.
Understanding the factors contributing to tumor initiation, progression and evolution is of paramount significance. Among them, wild-type p53-induced phosphatase 1 (Wip1) is emerging as an important oncogene by virtue of its negative control on several key tumor suppressor pathways. Originally discovered as a p53-regulated gene, Wip1 has been subsequently found amplified and more recently mutated in a significant fraction of human cancers including breast tumors. Recent development in the field further uncovered the utility of anti-Wip1-directed therapies in delaying tumor onset or in reducing the tumor burden. Furthermore, Wip1 could be an important factor that contributes to tumor heterogeneity, suggesting that its inhibition may decrease the rate of cancer evolution. These effects depend on several signaling pathways modulated by Wip1 phosphatase in a spatial and temporal manner. In this review we discuss the recent development in understanding how Wip1 contributes to tumorigenesis with its relevance to breast cancer.
Institute for Research on Cancer and Aging of Nice (IRCAN), INSERM, U1081-UMR CNRS 7284, University of Nice - Sophia Antipolis, Centre Antoine Lacassagne, Nice, France.
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Emelyanov
Institute for Research on Cancer and Aging of Nice (IRCAN), INSERM, U1081-UMR CNRS 7284, University of Nice - Sophia Antipolis, Centre Antoine Lacassagne, Nice, France.|Institute of Molecular and Cell Biology, Proteos, Singapore, Singapore.
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Bulavin
D001940:Breast / Q000254:growth & development; D001943:Breast Neoplasms / Q000209:etiology*; D003564:Cytidine Deaminase / Q000235:genetics; D004249:DNA Damage; D005260:Female; D024522:Genes, BRCA2; D016158:Genes, p53; D006570:Heterochromatin; D006801:Humans; D015778:Minor Histocompatibility Antigens; D009154:Mutation; D009857:Oncogenes; D010749:Phosphoprotein Phosphatases / Q000235:genetics / Q000502:physiology*; D000071636:Protein Phosphatase 2C; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D051155:Wnt1 Protein / Q000502:physiology
D003564:Cytidine Deaminase; D006570:Heterochromatin; D015778:Minor Histocompatibility Antigens; D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C; D018719:Erb-b2 Receptor Tyrosine Kinases; D051155:Wnt1 Protein; C495247:WNT1 protein, human; C508053:ERBB2 protein, human; C000607458:PPM1D protein, human; C495794:APOBEC3B protein, human