Up against the wall: is yeast cell wall integrity ensured by mechanosensing in plasma membrane microdomains?
Yeast cell wall integrity (CWI) signaling serves as a model of the regulation of fungal cell wall synthesis and provides the basis for the development of antifungal drugs. A set of five membrane-spanning sensors (Wsc1 to Wsc3, Mid2, and Mtl1) detect cell surface stress and commence the signaling pathway upon perturbations of either the cell wall structure or the plasma membrane. We here summarize the latest advances in the structure/function relationship primarily of the Wsc1 sensor and critically review the evidence that it acts as a mechanosensor. The relevance and physiological significance of the information obtained for the function of the other CWI sensors, as well as expected future developments, are discussed.
Universität Osnabrück, Fachbereich Biologie/Chemie, AG Genetik, Osnabrück, Germany.
Christian
C
Kock
Université Catholique de Louvain, Institute of Life Sciences, Louvain-la-Neuve, Belgium.
Yves F
YF
Dufrêne
Universität Osnabrück, Fachbereich Biologie/Chemie, AG Genetik, Osnabrück, Germany heinisch@biologie.uni-osnabrueck.de.
Jürgen J
JJ
Heinisch
D002462:Cell Membrane / Q000378:metabolism*; D002473:Cell Wall / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D012440:Saccharomyces / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction
D008565:Membrane Proteins; C119383:SLG1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins