Protein kinase Cθ: the pleiotropic T-cell signalling intermediate.
Activating as well as inhibitory circuits tightly regulate T-cell activation thresholds and effector differentiation processes enabling proper immune response outcomes. Recently, an additional molecular link between T-cell receptor signalling and CD4⁺ Th17 cell skewing has been reported, namely that protein kinase C (PKC) θ critically regulates Th17/Th1 phenotypic differentiation and plasticity in CD4⁺ T-cells by selectively acting as a 'reprogramming element' that suppresses Th1-typical genes during Th17-mediated immune activation in order to stabilize a Th17 cell phenotype.
*Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A-6020 Innsbruck, Austria.
Katarzyna
K
Wachowicz
*Translational Cell Genetics, Department of Pharmacology and Genetics, Medical University of Innsbruck, Peter Mayr Strasse 1a, A-6020 Innsbruck, Austria.
Gottfried
G
Baier
D006801:Humans; D007527:Isoenzymes; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*
D007527:Isoenzymes; C076233:PRKCQ protein, human; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta