Metal-organic framework based highly selective fluorescence turn-on probe for hydrogen sulphide.
Hydrogen sulphide (H2S) is known to play a vital role in human physiology and pathology which stimulated interest in understanding complex behaviour of H2S. Discerning the pathways of H2S production and its mode of action is still a challenge owing to its volatile and reactive nature. Herein we report azide functionalized metal-organic framework (MOF) as a selective turn-on fluorescent probe for H2S detection. The MOF shows highly selective and fast response towards H2S even in presence of other relevant biomolecules. Low cytotoxicity and H2S detection in live cells, demonstrate the potential of MOF towards monitoring H2S chemistry in biological system. To the best of our knowledge this is the first example of MOF that exhibit fast and highly selective fluorescence turn-on response towards H2S under physiological conditions.
Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Sanjog S
SS
Nagarkar
Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Tanmoy
T
Saha
Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Aamod V
AV
Desai
Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Pinaki
P
Talukdar
Indian Institute of Science Education &Research (IISER), Pune Dr. Homi Bhabha Road, Pashan, Pune-411008 (India).
Sujit K
SK
Ghosh
D002460:Cell Line; D002470:Cell Survival; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D009930:Organic Chemicals / Q000737:chemistry*
D005456:Fluorescent Dyes; D008670:Metals; D009930:Organic Chemicals; D006862:Hydrogen Sulfide