Twenty years of KSHV.
Twenty years ago, Kaposi's sarcoma (KS) was the oncologic counterpart to Winston Churchill's Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men-in fact, most KS patients were expected to die with the tumor rather than from it. Nevertheless, the course and manifestations of the disease varied widely in different clinical contexts. The puzzle of KS came to the forefront as a harbinger of the AIDS epidemic. The articles in this issue of Viruses recount progress made in understanding Kaposi's sarcoma herpesvirus (KSHV) since its initial description in 1994.
Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA. yc70@pitt.edu.
Yuan
Y
Chang
Cancer Virology Program, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA. psm9@pitt.edu.
Patrick
P
Moore
D006566:Herpesviridae Infections / Q000453:epidemiology* / Q000473:pathology* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000302:isolation & purification* / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D054884:Host-Pathogen Interactions; D006801:Humans; D014773:Virology / Q000266:history*