Short and straightforward synthesis of triphosphates of artificial nucleobase pairs displaying unconventional pairing scheme.
Concise, facile and efficient synthesis of 5'-O-triphosphates of 6-amino-5-nitro-3-(1'-β-D-2'-deoxyribofuranosyl)-2(1H)-pyridone (dZ) and its Watson-Crick complement 2-amino-8-(1'-β-D-2'-deoxyribofuranosyl)-imidazo[1,2a]-1,3,5-triazin-4(8H)-one (dP) is reported using a one-pot synthetic procedure.
a Bioorganic Chemistry Division , Life Sciences Solutions Group, Thermo Fisher Scientific , Austin , TX , USA.
Anilkumar R
AR
Kore
Bo
B
Yang
Balasubramanian
B
Srinivasan
D020029:Base Pairing; D003853:Deoxyribonucleosides / Q000737:chemistry; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D009005:Monosaccharides / Q000737:chemistry; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
C547310:2-amino-8-(1'-beta-D-2'-deoxyribofuranosyl)-imidazo(1,2-a)-1,3,5-triazin-4(8 H)-one; C515830:6-amino-5-nitro-3-(1'-(2'-deoxyribofuranosyl))-2(1H)-pyridone; D003853:Deoxyribonucleosides; D007093:Imidazoles; D009005:Monosaccharides; D009711:Nucleotides; D011728:Pyridones; D014227:Triazines
Artificial nucleobase; concise synthesis; nucleoside triphosphate; one-pot methodology; phosphorylation