A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics.
Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Laurens T
LT
van der Meer
Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Esmé
E
Waanders
Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Marloes
M
Levers
Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Hanka
H
Venselaar
Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Debbie
D
Roeleveld
Department of Pediatric Hematology and Oncology, University Children's Hospital of Münster, Münster, Germany.
Joachim
J
Boos
Department of Pediatric Hematology and Oncology, University Children's Hospital of Münster, Münster, Germany.
Claudia
C
Lanvers
Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.
Roger J
RJ
Brüggemann
Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Roland P
RP
Kuiper
Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
Peter M
PM
Hoogerbrugge
Laboratory of Pediatric Oncology, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Frank N
FN
van Leeuwen
Pediatric Hemato-Oncology, Department of Pediatrics, Radboud University Medical Center, Nijmegen, The Netherlands.
D Maroeska
DM
te Loo
D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001215:Asparaginase / Q000493:pharmacokinetics*; D002401:Cathepsin B / Q000235:genetics*; D002648:Child; D016903:Drug Monitoring / Q000379:methods; D005260:Female; D018095:Germ-Line Mutation; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*
D000970:Antineoplastic Agents; C533912:CTSB protein, human; D002401:Cathepsin B; D001215:Asparaginase