Ebola outbreak in Conakry, Guinea: epidemiological, clinical, and outcome features.
OBJECTIVE
The authors studied the epidemiological, clinical, and outcome features of the Ebola virus disease in patients hospitalized at the Ebola treatment center (ETC) in Conakry to identify clinical factors associated with death.


METHODS
A prospective study was conducted from March 25 to August 20, 2014. The diagnosis of Ebola virus infection was made on real-time PCR.


RESULTS
Ninety patients, with a positive test result, were hospitalized. Their mean age was 34.12±14.29 years and 63% were male patients. Most worked in the informal sector (38%) and in the medical and paramedical staff (physicians 12%, nurses 6%, and laboratory technicians 1%). Most patients lived in the Conakry suburbs (74%) and in Boffa (11%). The main clinical signs were physical asthenia (80%) and fever (72%). Hemorrhagic signs were observed in 26% of patients. The comparison of clinical manifestations showed that hiccups (P=0.04), respiratory distress (P=0.04), and hemorrhagic symptoms (P=0.01) were more frequent among patients who died. Malaria (72%) and diabetes (2%) were the most frequent co-morbidities. The crude case fatality rate was 44% [95% confidence interval (33-54%)]. The average hospital stay was 7.96±5.81 days.


CONCLUSIONS
The first Ebola outbreak in Conakry was characterized by the young age of patients, discrete hemorrhagic signs related to lethality. Its control relies on a strict use of preventive measures.
Service des maladies infectieuses et tropicales, hôpital national Donka, CHU de Conakry, Quartier Cameroun, Conakry, Guinea.
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Barry
Service des maladies infectieuses et tropicales, hôpital national Donka, CHU de Conakry, Quartier Cameroun, Conakry, Guinea; Chaire de dermatologie et maladies infectieuses, département de médecine, université de Conakry, Conakry, Guinea. Electronic address: fatraore01@gmail.com.
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Traoré
Service des maladies infectieuses et tropicales, hôpital national Donka, CHU de Conakry, Quartier Cameroun, Conakry, Guinea; Chaire de dermatologie et maladies infectieuses, département de médecine, université de Conakry, Conakry, Guinea.
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Sako
Service des maladies infectieuses et tropicales, hôpital national Donka, CHU de Conakry, Quartier Cameroun, Conakry, Guinea.
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Kpamy
Service des maladies infectieuses et tropicales, hôpital national Donka, CHU de Conakry, Quartier Cameroun, Conakry, Guinea.
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Bah
Coordonateur projet MSF urgence Ebola, hôpital Donka, Conakry, Guinea.
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Poncin
Division de la prévention et de la lutte contre la maladie, ministère de la Santé, Guinea.
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Keita
Chaire de dermatologie et maladies infectieuses, département de médecine, université de Conakry, Conakry, Guinea.
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Cisse
Chaire de santé publique, département de pharmacie, université de Conakry, Conakry, Guinea.
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Touré
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D015897:Comorbidity; D003920:Diabetes Mellitus / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D016701:Guinea / Q000453:epidemiology; D006282:Health Personnel; D019142:Hemorrhagic Fever, Ebola / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D017052:Hospital Mortality; D006801:Humans; D007223:Infant; D007902:Length of Stay / Q000706:statistics & numerical data; D008288:Malaria / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D060888:Real-Time Polymerase Chain Reaction; D012769:Shock / Q000209:etiology / Q000401:mortality; D063189:Symptom Assessment; D055815:Young Adult
Conakry; Ebola; Guinea ZEBOV