Emergence of antinuclear antibodies in psoriatic patients treated with infliximab: personal experience and literature review.
Psoriasis is a chronic inflammatory skin disease affecting up to 2.5% of the population, with joint involvement in approximately 30% of patients. Given the role of tumor necrosis factor (TNF) in the pathogenesis of psoriasis, anti-TNF therapies have been developed; several studies have demonstrated the efficacy of infliximab (IFX) as induction and maintenance therapy in the treatment of moderate to severe plaque psoriasis. The development of antinuclear antibodies (ANA) in anti-TNF-treated patients has been frequently reported. The aim of this study was to investigate the incidence of ANA and anti-double stranded DNA (anti-dsDNA) antibodies in psoriatic patients receiving IFX. Incidence of new ANA and anti-ds-DNA was 16.2% and 8.1% respectively. No case of anti-TNF induced Lupus was observed during the follow-up.
Dipartimento di "Medicina dei Sistemi"-Reumatologia, Allergologia e Immunologia Clinica, Università di Rome "Tor Vergata", 00163, Rome, Italy.
Maria Sole
MS
Chimenti
Francesca Romana
FR
Spinelli
Alessandro
A
Giunta
Francesco
F
Martinelli
Rosita
R
Saraceno
Fabrizio
F
Conti
Roberto
R
Perricone
Guido
G
Valesini
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D000069285:Infliximab; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab
anti-TNF; anti-nuclear-antibodies; disease activity; psoriasis