A new class of quinazoline-sulfonamides acting as efficient inhibitors against the α-carbonic anhydrase from Trypanosoma cruzi.
The protozoan parasite Trypanosoma cruzi is the agent responsible for trypanosomiasis (Chagas disease) in humans and other animals. It has been recently reported that this pathogen encodes for an α-class carbonic anhydrase (CA, EC 4.2.1.1), denominated TcCA, which was shown to be crucial for its life cycle. Inhibition studies of a class of 4-oxoquinazoline containing a benzensulfonamide moiety and their 4-thioxo bioisosteres against the protozoan enzyme TcCA are described here. Most of 4-oxoquinazoline sulfonamides showed nanomolar TcCA inhibition activity with K(I)s in the same order of magnitude of acetazolamide (AAZ), whereas their thioxo bioisosters showed moderate anti-Trypanosoma CA potency with K(I)s in the micromolar range. The discovery of compounds incorporating a 4-oxoquinazoline ring as a low-nanomolar TcCA inhibitor is quite promising and it may be useful for developing anti-Trypanosoma agents with a novel mechanism of action compared to the clinically used drugs (such as benznidazole, nifurtimox) for which significant resistance and serious adverse effects due to their high-toxicity appeared.
Department of Pharmaceutical Chemistry, College of Pharmacy, Salman bin Abdulaziz University , Al-Kharj , Saudi Arabia .
Ahmed M
AM
Alafeefy
Mariangela
M
Ceruso
Nabila A
NA
Al-Jaber
Seppo
S
Parkkila
Alane Beatriz
AB
Vermelho
Claudiu T
CT
Supuran
D000818:Animals; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000201:enzymology*
D002257:Carbonic Anhydrase Inhibitors; D011799:Quinazolines; D013449:Sulfonamides
Trypanosoma cruzi; enzyme inhibitor; quinazoline; sulfonamide; α-Carbonic anhydrase