Detection beyond Debye's length with an electrolyte-gated organic field-effect transistor.
Electrolyte-gated organic field-effect transistors are successfully used as biosensors to detect binding events occurring at distances from the transistor electronic channel that are much larger than the Debye length in highly concentrated solutions. The sensing mechanism is mainly capacitive and is due to the formation of Donnan's equilibria within the protein layer, leading to an extra capacitance (CDON) in series to the gating system.
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, CSGI and INSTM, Via Orabona 4, 70126, Bari, Italy.
Gerardo
G
Palazzo
Donato
D
De Tullio
Maria
M
Magliulo
Antonia
A
Mallardi
Francesca
F
Intranuovo
Mohammad Yusuf
MY
Mulla
Pietro
P
Favia
Inger
I
Vikholm-Lundin
Luisa
L
Torsi
D001360:Avidin / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation*; D004573:Electrolytes / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009930:Organic Chemicals / Q000737:chemistry*; D009994:Osmolar Concentration; D019809:Streptavidin / Q000737:chemistry; D013876:Thiophenes / Q000737:chemistry; D014173:Transistors, Electronic
D004573:Electrolytes; D009930:Organic Chemicals; D013876:Thiophenes; C507295:poly(3-hexylthiophene); D001360:Avidin; D019809:Streptavidin
Donnan equilibria; biosensors; electrostatic double layers; organic field-effect transistors; sensors