The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins.
The transient receptor potential cation channel subfamily V member 6 (TRPV6) gene and cDNA were identified 15 years ago and exceptional observations on TrpV6 proteins and their function as a Ca(2+)-selective cation channel have been made since then. In this review we will summarize recent studies regarding the genetics, biochemical properties, and physiological functions of murine and human TrpV6 channel proteins. We will focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2+) uptake, sperm maturation, and male fertility.
Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Universität des Saarlandes, 66421 Homburg, Germany.
Christof
C
Stoerger
Veit
V
Flockerzi
D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism; D005298:Fertility / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D010442:Peptide Chain Initiation, Translational / Q000502:physiology*; D011110:Polymorphism, Genetic; D013079:Sperm Maturation / Q000502:physiology*; D050916:TRPV Cation Channels / Q000235:genetics / Q000378:metabolism
D015220:Calcium Channels; D050916:TRPV Cation Channels; C422827:TRPV6 protein, human; C446923:Trpv6 protein, mouse
TRPV6 channel; calcium channel; canal TRPV6; canal calcique; potentiel récepteur transitoire; transient receptor potential