Factors predicting survival in peripheral T-cell lymphoma in the USA: a population-based analysis of 8802 patients in the modern era.
Current prognostic models for peripheral T-cell lymphoma (PTCL) have multiple limitations, and questions exist regarding applicability to current patients. We utilized the Surveillance Epidemiology and End Results (SEER)-18 database to evaluate factors affecting overall survival (OS) of PTCL in the modern era and identified 8802 patients between 2000-2010. Most subtypes of PTCL increased in incidence during the study period. In univariate analyses, age >55 years, black race, advanced stage, absence of extra-nodal disease, omission of radiation therapy (RT) and high-risk histology each predicted inferior OS (P < 0·0001). Multivariate analysis (MVA) demonstrated that hepatosplenic, enteropathy-associated and extra-nodal Natural Killer/T cell histologies, each had hazard ratios >1·5 (P ≤ 0·0001) for death. Further, age ≥55 years, black race and advanced stage maintained their significance in the MVA (P < 0·0001 each). Based on the significant factors, a prognostic model was constructed and subsequently validated in an independent cohort. The new model incorporated age, stage, histology and race, with an OS ranging from 9 months (highest risk group) to 120 months (lowest risk group). In summary, this is the largest study of PTCL patients in the modern era that provides risk stratification utilizing a new prognostic model that can be incorporated into future prospective clinical trials.
Division of Hematology/Oncology, Northwestern University, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
Adam M
AM
Petrich
Irene B
IB
Helenowski
Locke J
LJ
Bryan
Shaina A
SA
Rozell
Robert
R
Galamaga
Chadi
C
Nabhan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007694:Killer Cells, Natural / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D008954:Models, Biological; D012307:Risk Factors; D015996:Survival Rate; D013601:T-Lymphocytes / Q000473:pathology; D014481:United States / Q000453:epidemiology
T-cell lymphoma; histopathology; prognostic factors; radiotherapy