Increased susceptibility of sepsis associated with CD143 deletion/insertion polymorphism in Caucasians: a meta analysis.
BACKGROUND
Several lines of evidence have reported that serum angiotensin-converting enzyme (CD143) levels are genetically regulated by insertion/deletion (ins/del) polymorphism in intron 16 of the CD143 gene. In addition, published data on the association of ins/del polymorphism and sepsis risk yielded contradictory conclusions. Therefore, we determined to perform a meta-analysis to validate the association of much debate. Methods and major findings: Relevant literature was identified through weekly searches in databases and references of systematic reviews and the single studies incorporated in this meta-analysis. We combined ORs and its 95% CIs for several genetic models to evaluate the risk of sepsis associated with ins/del polymorphism. A total of seven studies were considered eligible for this analysis. We found significantly increased risk of sepsis in relation to the homozygote ins/ins (OR: 1.32, 95% CI: 1.04-1.68, P: 0.4201, for ins/ins vs. del/del), heterozygote del/ins (OR: 1.33, 95% CI: 1.11-1.61, P: 0.7937, for del/ins vs. del/del) and the two genotypes combined (OR: 1.33, 95% CI: 1.11-1.59, P: 0.7018, for ins/ins + del/ins vs. del/del). Subgroup analysis by age group showed a significant association in pediatric sepsis, but not in adult sepsis.


CONCLUSIONS
The statistical data suggest that the CD143 gene ins/del polymorphism may influence the risk of sepsis, especially pediatric sepsis.
Department of Burn & Plastic Surgery, The First Affilated Hospital of PLA General Hospital Beijing, China.
Hongming
H
Yang
Department of Burn & Plastic Surgery, The First Affilated Hospital of PLA General Hospital Beijing, China.
Yihe
Y
Wang
Department of Burn & Plastic Surgery, The First Affilated Hospital of PLA General Hospital Beijing, China.
Lingying
L
Liu
Department of Burn & Plastic Surgery, The First Affilated Hospital of PLA General Hospital Beijing, China.
Quan
Q
Hu
D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D002648:Child; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D018805:Sepsis / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics*
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A
CD143-ins/del polymorphism-sepsis