Gastroesophageal reflux in young children and adolescents: Is there a relation between symptom severity and esophageal histological grade?
BACKGROUND
The pediatric literature about the correlation between symptoms and histological lesions in patients investigated for gastroesophageal reflux disease is scarce and inconclusive. The primary aim of the present study was to assess the relation between the complained symptom severity and the esophageal histological grade, through the use of validated and reliable scores.


METHODS
All children ages between 2 and 17 years referred to perform upper gastrointestinal endoscopy because of gastroesophageal reflux disease symptoms were asked to complete the Pediatric Gastroesophageal Symptom and Quality of Life validated questionnaire, investigating the main symptoms complained and their impact on daily life and school activities. Esophageal mucosal samples taken during the procedure were analyzed and scored according to the Yerian-Fiocca classification.


RESULTS
A total of 164 children were included in the study. No significant association was found between symptomatic score and histological score (r(s): 0.05, P: 0.49). Even when focusing only on adolescents with heartburn or chest pain, no correlation between symptom severity and esophageal lesions was found (r(s): -0.18, P: 0.264). Intercellular space diameter values did not mirror symptom severity.


CONCLUSIONS
The main finding of this study on children with reflux symptoms is the lack of correlation between symptom severity and esophageal histological grade. The magnitude of intercellular spaces was found not to be related with the clinical score as well.
*Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Naples †Department of Pediatrics, "La Sapienza" University, Rome ‡Department of Advanced Biomedical Sciences, Section of Pathology, University of Naples, Naples §Department of Radiological Sciences, Oncology, and Anatomical Pathology, "La Sapienza" University, Rome, Italy.
Paolo
P
Quitadamo
Giovanni
G
Di Nardo
Erasmo
E
Miele
Severo
S
Campione
Valeria
V
Mancusi
Salvatore
S
Oliva
Paolo
P
Rossi
Antonio
A
Tiberti
Annamaria
A
Staiano
Maria
M
D'Armiento
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D016099:Endoscopy, Gastrointestinal; D004941:Esophagitis / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D004947:Esophagus / Q000276:immunology / Q000473:pathology*; D005110:Extracellular Space / Q000276:immunology; D005260:Female; D005764:Gastroesophageal Reflux / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology*; D010044:Outpatient Clinics, Hospital; D011446:Prospective Studies; D011788:Quality of Life; D012017:Referral and Consultation; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires