"AND" logic gate regulated pH and reduction dual-responsive prodrug nanoparticles for efficient intracellular anticancer drug delivery.
A dual-responsive drug delivery system simulating an AND logic gate is developed by core-cross-linking of a disulfide-containing anticancer prodrug with Cu(2+) for safe and efficient delivery of anticancer drugs. These prodrug nanoparticles are stable and exhibit nearly no premature drug release, and allow a fast drug release under simulated intracellular conditions, realizing a precise drug delivery towards cell nuclei.
Center for Degradable and Flame-Retardant Polymeric Materials (ERCPM-MoE), College of Chemistry, State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), Sichuan University, 29 Wangjiang Road, Chengdu 610064, China. songfei520@gmail.com yzwang@scu.edu.cn.
Lan
L
Bai
Xiao-hui
XH
Wang
Fei
F
Song
Xiu-li
XL
Wang
Yu-zhong
YZ
Wang
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000633:toxicity; D002467:Cell Nucleus / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry* / Q000633:toxicity
D000970:Antineoplastic Agents; D004337:Drug Carriers; D011355:Prodrugs; D011092:Polyethylene Glycols; D003300:Copper; D004317:Doxorubicin