Fructose-coated nanoparticles: a promising drug nanocarrier for triple-negative breast cancer therapy.
Fructose transporter GLUT5 is overexpressed in breast cancer cell lines, but not in healthy tissue. Micelles based on fructose, which were found to be low fouling, showed a high uptake by breast cancer cells (MCF-7 and MDA-MB-231 cells), but only negligible uptake by macrophages.
Centre for Advanced Macromolecular Design, School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia. M.Stenzel@unsw.edu.au.
Jiacheng
J
Zhao
Krzysztof
K
Babiuch
Hongxu
H
Lu
Aydan
A
Dag
Michael
M
Gottschaldt
Martina H
MH
Stenzel
D000818:Animals; D001692:Biological Transport; D016466:CHO Cells; D045744:Cell Line, Tumor; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D005434:Flow Cytometry; D005632:Fructose / Q000737:chemistry*; D051296:Glucose Transporter Type 5 / Q000378:metabolism; D006801:Humans; D061986:MCF-7 Cells; D051379:Mice; D008823:Micelles; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry; D011485:Protein Binding; D064726:Triple Negative Breast Neoplasms / Q000378:metabolism / Q000473:pathology
D051296:Glucose Transporter Type 5; D008823:Micelles; D011108:Polymers; C495726:SLC2A5 protein, human; D005632:Fructose