Enzymatic 'stripping' and degradation of PEGylated carbon nanotubes.
Single-walled carbon nanotubes (SWCNTs) coated or functionalized with PEG chains of different molecular weight were assessed for their propensity to undergo biodegradation under in vitro conditions using recombinant myeloperoxidase (MPO) or ex vivo using freshly isolated primary human neutrophils. Our findings suggest that under natural conditions, a combined process of 'stripping' (i.e., defunctionalization) and biodegradation of PEG-SWCNTs might occur and that PEG-SWCNTs are a promising--and degradable--nanomedicine vector.
Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Stockholm 171 77, Sweden. bengt.fadeel@ki.se.
Kunal
K
Bhattacharya
Cristiano
C
Sacchetti
Ramy
R
El-Sayed
Andrea
A
Fornara
Gregg P
GP
Kotchey
James A
JA
Gaugler
Alexander
A
Star
Massimo
M
Bottini
Bengt
B
Fadeel
D002478:Cells, Cultured; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis; D015195:Drug Design; D004343:Drug Implants / Q000737:chemistry*; D006801:Humans; D008970:Molecular Weight; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009504:Neutrophils / Q000201:enzymology*; D010316:Particle Size; D009195:Peroxidase / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013379:Substrate Specificity
D020099:Coated Materials, Biocompatible; D004343:Drug Implants; D053769:Nanocapsules; D037742:Nanotubes, Carbon; D011092:Polyethylene Glycols; D009195:Peroxidase