Prevention of Diabetes Through the Lifestyle Intervention: Lessons Learned from the Diabetes Prevention Program and Outcomes Study and its Translation to Practice.
A number of strategies have been used to delay or prevent the development of type 2 diabetes mellitus (T2D) in high-risk adults. Among them were diet, exercise, medications and surgery. This report focuses on the nutritional lessons learned from implementation of the Intensive Lifestyle Intervention (ILI) in the DPP and its follow-up DPPOS that looked at weight loss through modification of diet and exercise. The Diabetes Prevention Program (DPP) is a large clinical trial, sponsored by the National Institutes of Health, designed to look at several strategies to prevent conversion to type 2 diabetes (T2D) by adults with prediabetes (IGT/IFG) including an Intensive Lifestyle Intervention (ILI). The ∼3800 ethnically diverse participants (46% reported non-white race) were overweight, had impaired glucose tolerance (IGT) and impaired fasting glucose (IFG). Treatments were assigned randomly. The Diabetes Prevention Program Outcomes Study (DPPOS) is a follow up study evaluating the long-term outcomes of the clinical trial.
ACKCO, American Indian Professional Services, Inc. Phoenix, AZ.
Mary A
MA
Hoskin
Pennington Biomedical Center, Louisiana State University, Baton Rouge, LA.
George A
GA
Bray
University of Texas, San Antonio, TX.
Kathy
K
Hattaway
Washington University, St Louis, MO.
Prajakta A
PA
Khare-Ranade
Phoenix Epidemiology and Clinical Research Branch, NIDDK Phoenix, AZ.
Jeremy
J
Pomeroy
University of Pittsburgh, Pittsburgh, PA.
Linda N
LN
Semler
University of Pittsburgh, Pittsburgh, PA.
Valarie A
VA
Weinzierl
Albert Einstein College of Medicine, Bronx, NY.
Judith
J
Wylie-Rosett
Diabetes prevention; Lifestyle intervention; diabetes; diet; genetics; lifestyle; nutrition; overweight; physical activity; prevention; type 2 diabetes; weight loss