Prenatal Exposure to Angiotensin II Receptor Blockers and Hemodynamic Effects on the Newborn.
Angiotensin II receptor blockers (ARBs) are potent antihypertensive agents that block the renin angiotensin aldosterone system (RAS). Their use in pregnancy may cause malformations, oligoanuria, hypotension, and death. Hypotension is observed up to 15% of cases and is described as refractory to volume and inotropic support, although its pathophysiology is unknown. We present a case of prenatal exposure to ARBs in order to characterize the hemodynamic compromise in the newborn, help in decision-making, and guide the therapeutic approach to these patients.
Hospital Clínico San Carlos , Madrid , Spain.
MaJosé
M
Rodríguez-Castaño
Araceli
A
Corredera
Esther
E
Aleo
Luis
L
Arruza
D000328:Adult; D057912:Angiotensin II Type 2 Receptor Blockers / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects; D012084:Renin-Angiotensin System / Q000187:drug effects*
D057912:Angiotensin II Type 2 Receptor Blockers; D000959:Antihypertensive Agents
angiotensin II receptor blockers; hypotension; newborn; refractory