Delivery and targeting of nanoparticles into hair follicles.
It has been demonstrated that nanoparticles used for follicular delivery provide some advantages over conventional pathways, including improved skin bioavailability, enhanced penetration depth, prolonged residence duration, fast transport into the skin and tissue targeting. This review describes recent developments using nanotechnology approaches for drug delivery into the follicles. Different types of nanosystems may be employed for management of follicular permeation, such as polymeric nanoparticles, metallic nanocrystals, liposomes, and lipid nanoparticles. This review systematically introduces the mechanisms of follicles for nanoparticulate penetration, highlighting the therapeutic potential of drug-loaded nanoparticles for treating skin diseases. Special attention is paid to the use of nanoparticles in treating appendage-related disorders, in particular, nanomedical strategies for treating alopecia, acne, and transcutaneous immunization.
Department of Pathology, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chia-Lang
CL
Fang
Ibrahim A
IA
Aljuffali
Yi-Ching
YC
Li
Jia-You
JY
Fang
D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004337:Drug Carriers; D016503:Drug Delivery Systems; D018859:Hair Follicle / Q000378:metabolism*; D006801:Humans; D050997:Nanomedicine; D053758:Nanoparticles; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D012869:Skin Absorption; D013678:Technology, Pharmaceutical / Q000379:methods*
D004304:Dosage Forms; D004337:Drug Carriers; D004364:Pharmaceutical Preparations
hair follicle; nanocarrier; skin; skin targeting; topical drug delivery