Long-term outcome of liver transplantation in HCV/HIV coinfected haemophilia patients. A single centre study of 10 patients.
The outcome and clinical features during long term follow-up of 10 haemophilia patients (haemophilia A n = 9, haemophilia B n = 1), who underwent successful orthotopic liver transplantation (OLT) due to hepatitis associated liver disease, are summarised.


METHODS
Eight patients were HIV/HCV co-infected. Despite severe postoperative complications, which were not bleeding-associated, all patients survived OLT.


RESULTS
Long-term survival was 70% after in mean 8 years follow-up. Twelve years after OLT one patient developed a cyclosporine-induced nephropathy requiring haemodialysis. HIV-HAART was initiated in all patients after OLT, and allowed a successful HCV treatment in 6 patients. Factor VIII production was sufficient in mean 72 h after OLT and remained stable at subnormal to normal FVIII levels of in median 30% (range 14-96%) also during long-term follow-up. Post-OLT spontaneous bleeding events were rare compared to pre-OLT, therefore, the performance status improved in all patients.


CONCLUSIONS
OLT substitutes the hepatic FVIII but has no effect on the extra-hepatic endothelial FVIII production, suggesting that in case of severe tissue injury enhanced bleeding might occur. Additionally, after OLT there is no acute phase reaction of the FVIII protein. Therefore, our OLT patients received in case of a reduced FVIII activity a peri-interventional prophylactic short-term FVIII substitution in surgical and diagnostic interventions with high bleeding risk.


CONCLUSIONS
Bleeding and wound healing disturbances were not seen.
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Goldmann
Zeitler Heike, MD, Internal Medical Clinic I, CETA, University of Bonn, Sigmund-Freud-Str. 27, 53127 Bonn, Germany, Tel. +49/(0)2 28/28 71 36-28, Fax -30, E-mail: heike.zeitler@ukb.uni-bonn.de.
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Zeitler
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Marquardt
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Horneff
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Balta
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Strassburg
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Oldenburg
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis; D006470:Hemorrhage / Q000209:etiology* / Q000517:prevention & control; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
Haemophilia; factor VIII; hepatitis; inhibitor; liver transplantation