Rare case of primary inferior vena cava leiomyosarcoma on F-18 fluorodeoxyglucose positron emission tomography-computed tomography scan: Differentiation from nontumor thrombus in a background of procoagulant state.
We report a rare case of leiomyosarcoma of the inferior vena cava (IVC) in which F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography-computed tomography (PET-CT) scan provided vital evidence, which led to its diagnosis, in a background of procoagulant state of the patient, where previous ultrasound-Doppler and echocardiography studies were nonspecific and revealed bilateral lower limb deep vein thrombosis with thrombus in IVC. The whole body F-18 FDG PET-CT scan was done in view of no significant improvement in clinical status of the patient over few months in spite of appropriate medical management. FDG PET-CT scan revealed high grade uptake in a large mass lesion occupying the right atrium, extending superiorly into terminal superior vena cava, inferiorly into dilated IVC and probably into hepatic veins. CT guided biopsy of this F-18 FDG avid mass was consistent with the diagnosis of leiomyosarcoma, which however was not amenable to surgery at this stage. F-18 FDG PET-CT accurately differentiated tumor mass from bland thrombus and further had a significant impact on the management, since aggressive surgery combined with adjuvant therapy offers the best outcome for patients with leiomyosarcoma of the IVC.
Department of Nuclear Medicine and PET-CT, P.D. Hinduja Hospital and MRC, Mahim, Mumbai, Maharashtra, India.
Natasha
N
Singh
Department of Nuclear Medicine and PET-CT, P.D. Hinduja Hospital and MRC, Mahim, Mumbai, Maharashtra, India.
Divya
D
Shivdasani
Department of Nuclear Medicine and PET-CT, P.D. Hinduja Hospital and MRC, Mahim, Mumbai, Maharashtra, India.
Sanket
S
Karangutkar
F-18 fluorodeoxyglucose; inferior vena cava leiomyosarcoma; positron emission tomography/computed tomography scan; surgical management; thrombus in procoagulant state