Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex.
In the present study, we investigated the characteristics of drug efflux transporter expressions following status epilepticus (SE). In the hippocampus and piriform cortex (PC), vasogenic edema peaked 3-4 days after SE. The expression of breast cancer resistance protein (BCRP), multidrug resistance protein-4 (MRP4), and p-glycoprotein (p-GP) were decreased 4 days after SE when vasogenic edema was peaked, but subsequently increased 4 weeks after SE. Multidrug resistance protein-1 (MRP1) expression gradually decreased in endothelial cells until 4 weeks after SE. These findings indicate that SE-induced vasogenic edema formation transiently reduced drug efflux pump expressions in endothelial cells. Subsequently, during recovery of vasogenic edema drug efflux pump expressions were differentially upregulated in astrocytes, neuropils, and endothelial cells. Therefore, we suggest that vasogenic edema formation may be a risk factor in pharmacoresistent epilepsy.
Department of Anatomy and Neurobiology, College of Medicine, Hallym University; Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Yeon-Joo
YJ
Kim
Department of Anatomy and Neurobiology, College of Medicine, Hallym University; Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Ji-Eun
JE
Kim
Institute of Epilepsy Research, College of Medicine, Hallym University; Department of Neurology, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Hui-Chul
HC
Choi
Institute of Epilepsy Research, College of Medicine, Hallym University; Department of Neurology, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Hong-Ki
HK
Song
Department of Anatomy and Neurobiology, College of Medicine, Hallym University; Institute of Epilepsy Research, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Tae-Cheon
TC
Kang
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001929:Brain Edema / Q000378:metabolism* / Q000473:pathology*; D004195:Disease Models, Animal; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D066195:Piriform Cortex / Q000378:metabolism* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters