Assessment of Exposure to Polybrominated Dipheny Ethers via Inhalation and Diet in China.
OBJECTIVE
This paper is to assess the current status of polybrominated diphenyl ethers (PBDEs) contamination in the environment in China and estimate the exposure to PBDEs in non-occupational populations.


METHODS
A total of 80 research papers published from January 2001 to October 2013 were selected. Geographic information system (GIS) was used in mapping PBDE concentrations and distributions in environmental media. Ni's model was applied to calculate ∑PBDE-intake via the intakes of contaminated food, water and air in the Pearl River Delta and Yangtze River Delta.


RESULTS
BDE-209 was found to be the major PBDE congener in the environmental media and food in China. PBDE concentrations varied among different areas, among which the contamination in Guangdong Province was most serious. Daily intake of ∑PBDEs was 225.1-446.0 ng/d for adults in the Pearl River Delta, which was higher than the intake for those living in the Yangtze River Delta (148.9-369.8 ng/d).


CONCLUSIONS
Atorvastatin can attenuate LPS-induced TNF-α expression and production by activating HO-1 via the ERK and p38 MAPK pathways, suggesting that atorvastatin can be used in treatment of inflammatory diseases such as sepsis, especially in those with atherosclerotic diseases.
Minhang District Center for Disease Control and Prevention, Shanghai 201101, China.
Li
L
Chen
Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China.
Dan
D
Cao
Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China.
Lu Xi
LX
Li
Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China.
Yan
Y
Zhao
Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China.
Chang Ming
CM
Xie
Key Laboratory of Public Health Safety, School of Public Health, Fudan University, Shanghai 200032, China.
Yun Hui
YH
Zhang
D002681:China; D004032:Diet; D004785:Environmental Pollutants / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis; D040362:Geographic Information Systems; D055768:Halogenated Diphenyl Ethers / Q000032:analysis*; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*
D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers
Daily intake; Exposure assessment; GIS; PBDE-distribution; PBDEs