Limonoid and Steroidal Saponin from Azadirachta indica.
A new limonoid, 17-(5-methoxy-2-oxofuran-3-yl)-28-deoxonimbolide (1), and a new C21 steroidal saponin, 2α,4α-dihydroxy-pregn-5-en-16-one-3α-O-D-glucopyranoside (2), together with 11 known compounds were isolated from the methanol extract of the leaves of Azadirachta indica. The structures were elucidated by means of spectroscopic analysis and putative biosynthetic origins. All the compounds were evaluated for their antibacterial activities against six bacterial strains.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Lu
L
Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
Yun-Li
YL
Zhao
Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China.
Gui-Guang
GG
Cheng
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Ying-Ying
YY
Chen
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Xu-Jie
XJ
Qin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Chang-Wei
CW
Song
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.|University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
Xing-Wei
XW
Yang
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. liuyaping@mail.kib.ac.cn.
Ya-Ping
YP
Liu
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. xdluo@mail.kib.ac.cn.
Xiao-Dong
XD
Luo
Antibacterial activities; Azadirachta indica; Limonoid; Steroidal saponin