The glioblastoma vasculature as a target for cancer therapy.
Glioblastoma is characterized by microvascular proliferation and a highly abnormal dysfunctional vasculature. The glioblastoma vessels differ significantly from normal brain vessels morphologically, functionally and molecularly. The present review provides a brief overview of the current understanding of the formation, functional abnormalities and specific gene expression of glioblastoma vessels and the consequences of vascular abnormalization for the tumour microenvironment.
*Department of Immunology, Genetics and Pathology, Science for Life Laboratory, The Rudbeck Laboratory, Uppsala University, 75185 Uppsala, Sweden.
Anna
A
Dimberg
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D015687:Cell Hypoxia; D015870:Gene Expression; D005909:Glioblastoma / Q000098:blood supply* / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology; D059016:Tumor Microenvironment
D020533:Angiogenesis Inhibitors