Bilateral diffuse uveal melanocytic proliferation associated with renal cell carcinoma.
OBJECTIVE
To report a case of bilateral diffuse uveal melanocytic proliferation associated with an asymptomatic renal cell carcinoma.


METHODS
Clinical case report.


METHODS
A 70-year-old man presented with a 7-month history of bilateral visual loss. Ophthalmoscopic examination, fluorescein angiography, ocular coherence tomography, and a search for underlying systemic malignancy were performed.


RESULTS
Examination revealed multiple melanocytic uveal proliferations in both eyes. Fluorescein angiography revealed a pattern of multiple areas of early hyperfluorescence, and ocular coherence tomography showed serous detachment of the central retina. Abdominal computerized tomography scans showed a large tumor in the left kidney and nodular involvement in the right kidney. Pathologic examination revealed a clear cell carcinoma of the kidney.


CONCLUSIONS
A literature review revealed a total of 40 cases of bilateral diffuse uveal melanocytic proliferation. To our knowledge, this is the first case to be associated with renal cell carcinoma.
Fundación Oftalmológica Los Andes, Santiago, Chile.
Juan
J
Verdaguer
Jorge
J
Oporto