Rhodium(III)-catalyzed olefinic C-H alkynylation of acrylamides using tosyl-imide as directing group.
The Rh(III)-catalyzed C-H alkynylation of acrylamide derivative is realized using a hypervalent alkynyl iodine reagent. The use of a weakly coordinating directing group proved to be of critical importance. This reaction displays broad functional group tolerance and high efficiency, which opens a new synthetic pathway to access functionalized 1,3-enyne skeletons.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University , 637371, Singapore.
Chao
C
Feng
Daming
D
Feng
Yang
Y
Luo
Teck-Peng
TP
Loh