Novel Antimicrobial Agents: Fluorinated 2-(3-(Benzofuran-2-yl) pyrazol-1-yl)thiazoles.
A new series of 2-pyrazolin-1-ylthiazoles 8a-d and 13-16 was synthesized by cyclization of N-thiocarboxamide-2-pyrazoline with different haloketones and 2,3-dichloroquinoxaline. The structures of the new compounds were confirmed by elemental analyses as well as NMR, IR, and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities, and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested ones, compound 8c displayed excellent antimicrobial activity.
Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
Hanan A
HA
Mohamed
Department of Chemistry, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Ehab
E
Abdel-Latif
Applied Organic Chemistry Department, National Research Centre, Dokki, Giza 12622, Egypt.
Bakr F
BF
Abdel-Wahab
Chemistry of Natural and Microbial Products, National Research Center, Dokki, Giza 12622, Egypt.
Ghada E A
GE
Awad