Vasculitis in antiphospholipid syndrome.
The major manifestations of antiphospholipid syndrome (APS) are caused by thrombosis within the venous or arterial vasculature, whereas the vascular lesions in systemic vasculitis result from an inflammatory infiltrate in the vessel wall. There is an association between vascular thrombosis and inflammation, however, as vasculitis can occur in APS and thromboembolic complications are seen in systemic vasculitis. Although differentiating between vasculitis and antiphospholipid-associated thrombosis can be difficult, it may be crucial to do so given the different therapeutic implications for immunosuppression or anticoagulation. This article explores the relationship between thrombosis and inflammation as it relates to APS and systemic vasculitis.
Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA. Electronic address: lallyl@hss.edu.
Lindsay
L
Lally
Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
Lisa R
LR
Sammaritano
D017152:Antibodies, Antiphospholipid / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D054068:Livedo Reticularis / Q000209:etiology*; D008171:Lung Diseases / Q000150:complications*; D031300:Retinal Vasculitis / Q000209:etiology*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology*; D014657:Vasculitis / Q000175:diagnosis / Q000209:etiology / Q000276:immunology
D017152:Antibodies, Antiphospholipid
Anti-β2-glycoprotein 1 antibody; Anticardiolipin antibody; Antiphospholipid syndrome; Lupus anticoagulant; Vasculitis