Refillable and magnetically actuated drug delivery system using pear-shaped viscoelastic membrane.
We report a refillable and valveless drug delivery device actuated by an external magnetic field for on-demand drug release to treat localized diseases. The device features a pear-shaped viscoelastic magnetic membrane inducing asymmetrical deflection and consecutive touchdown motion to the bottom of the dome-shaped drug reservoir in response to a magnetic field, thus achieving controlled discharge of the drug. Maximum drug release with 18 ± 1.5 μg per actuation was achieved under a 500 mT magnetic flux density, and various controlled drug doses were investigated with the combination of the number of accumulated actuations and the strength of the magnetic field.
Department of Mechanical Engineering, University of California , Berkeley, California 94720, USA.
Hongyun
H
So
Department of Mechanical and Mechatronics Engineering, Kangwon National University , Chuncheon, Gangwon-do 200-701, South Korea.
Young Ho
YH
Seo
Albert P
AP
Pisano