Higher levels of circulating chemerin in both lean and obese patients with polycystic ovary syndrome.
OBJECTIVE
The aim of this paper was to compare serum chemerin levels in nonobese and overweight/obese patients with polycystic ovary syndrome (PCOS) with lean controls.


METHODS
Seventy women with newly diagnosed or untreated PCOS and 38 age-matched nonobese healthy controls were enrolled in the present study. Participants with PCOS were categorized as nonobese (Body Mass Index [BMI] <25 kg/m², N.=36) or overweight/obese (BMI 25-29.9 kg/m² and ≥30 kg/m², respectively, N.=34). Anthropometric, metabolic and hormonal patterns, and serum chemerin were measured.


RESULTS
Serum chemerin tended to be higher in obese PCOS group than in nonobese PCOS women but did not reach statistical significance. Nonobese healthy controls had significantly lower chemerin levels than two PCOS groups (P<0.001). Fasting insulin (P<0.05) and homeostasis model assessment index (P<0.05) were significantly higher in obese women with PCOS than in other two groups. Also, these two parameters were higher in lean patients with PCOS than in healthy controls (P<0.05). In multiple linear regression analyses, chemerin was significantly associated with BMI (β-coefficient =0.336, P<0.01), and triglyceride (β-coefficient =0.298, P<0.05).


CONCLUSIONS
Chemerin levels were significantly increased not only in obese PCOS women but also in nonobese PCOS women. The physiological significance of elevated serum chemerin in PCOS remains unclear.
Department of Endocrinology and Metabolism Ankara Education and Research Hospital Ankara, Turkey - zehraberberoglu@gmail.com.
E
E
Ademoglu
Z
Z
Berberoglu
A
A
Carlioglu
F
F
Dellal
S
S
Gorar
Z
Z
Alphan
S
S
Uysal
F
F
Karakurt
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D016014:Linear Models; D009765:Obesity / Q000097:blood* / Q000150:complications; D050177:Overweight / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D018925:Chemokines; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D014280:Triglycerides