Prevalence of local recurrence of colorectal cancer at the Iranian Cancer Institute.
BACKGROUND
Although a great deal of progress has been made in the management of colorectal cancer in terms of neoadjuvant modalities, surgical techniques and adjuvant therapies, the recurrence of tumors remains an enigmatic complication in patients. A better understanding of colorectal cancer and of factors that lead to recurrence of disease can provide helpful information for designing more effective screening and surveillance methods.


OBJECTIVE
To investigate the factors that may lead to local recurrence of colorectal cancers.


METHODS
The current retrospective case study evaluated 617 patients admitted to the Iranian Cancer Institute (the largest referral cancer center in the country) from 1995 to 2009 with confirmed colorectal cancer. Patients with distant metastasis, or with pathology other than adenocarcinoma and no follow-up, were excluded (175 patients). The remainder (442) included 294 (66.5%) with rectal cancer and 148 (33.5%) with colon cancer. The median duration of follow-up was 26 months.


RESULTS
The total rate of recurrence was 17.4%, comprising 19.6% and 16.3% recurrence rates in colon and rectal cancer, respectively.


CONCLUSIONS
Recurrence of colorectal cancer was significantly correlated to tumor grade (p<0.008).
Department of Surgical Oncology, Faculty of Medicine, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran E-mail : dr94habib@yahoo.com.
Ramesh
R
Omranipour
Habibollah
H
Mahmoodzadeh
Farinaz
F
Safavi
D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D000328:Adult; D000368:Aged; D002173:Cancer Care Facilities; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000473:pathology*; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis