Ligand-controlled, tunable silver-catalyzed C-H amination.
The development of readily tunable and regioselective C-H functionalization reactions that operate solely through catalyst control remains a challenge in modern organic synthesis. Herein, we report that simple silver catalysts supported by common nitrogenated ligands can be used to tune a nitrene transfer reaction between two different types of C-H bonds. The results reported herein represent the first example of ligand-controlled and site-selective silver-promoted C-H amination.
Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53706, United States.
Juliet M
JM
Alderson
Alicia M
AM
Phelps
Ryan J
RJ
Scamp
Nicholas S
NS
Dolan
Jennifer M
JM
Schomaker
D000586:Amination; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*
D000588:Amines; D008024:Ligands; D009942:Organometallic Compounds; D012834:Silver