The use of magnesium sulfate for women with severe preeclampsia or eclampsia diagnosed during the postpartum period.
This was a systematic review of randomized controlled trials comparing anticonvulsants with placebo or no anticonvulsant for prevention (a) of eclampsia in women with severe preeclampsia diagnosed during the postpartum period or diagnosed before delivery but without previous treatment and (b) prevention of seizures recurrence in women with eclampsia postpartum. We did not find study with full inclusion criteria. However, a total of two randomised controlled trials meet inclusion criteria as subgroup analysis; one for severe preeclampsia diagnosed during the postpartum period and one for eclampsia postpartum. For severe preeclampsia diagnosed during postpartum, there was no clear difference between the groups reporting eclampsia (relative risk: 0.54, 95% confidence interval: 0.16-1.80). For seizure recurrence, magnesium sulfate was superior to diazepam, but there was no significant difference compared with phenytoin. No conclusion can be drawn on the role of magnesium sulfate post partum as established in antepartum pre-eclampsia/eclampsia management because of lack of powered randomised controlled trials.
a Complejo Hospitalario de la Caja de Seguro Social , Panama City , Panama and.
Paulino
P
Vigil-De Gracia
b Pennsylvania Hospital, Perelman School of Medicine at the University of Pennsylvania , Philadelphia , PA , USA.
Jack
J
Ludmir
D000927:Anticonvulsants / Q000627:therapeutic use*; D004461:Eclampsia / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D011644:Puerperal Disorders / Q000175:diagnosis / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000927:Anticonvulsants; D008278:Magnesium Sulfate
Magnesium sulfate; postpartum eclampsia; postpartum pre-eclampsia; severe pre-eclampsia