Fluorescent carbon nanoparticles derived from natural materials of mango fruit for bio-imaging probes.
Water soluble fluorescent carbon nanoparticles (FCP) obtained from a single natural source, mango fruit, were developed as unique materials for non-toxic bio-imaging with different colors and particle sizes. The prepared FCPs showed blue (FCP-B), green (FCP-G) and yellow (FCP-Y) fluorescence, derived by the controlled carbonization method. The FCPs demonstrated hydrodynamic diameters of 5-15 nm, holding great promise for clinical applications. The biocompatible FCPs demonstrated great potential in biological fields through the results of in vitro imaging and in vivo biodistribution. Using intravenously administered FCPs with different colored particles, we precisely defined the clearance and biodistribution, showing rapid and efficient urinary excretion for safe elimination from the body. These findings therefore suggest the promising possibility of using natural sources for producing fluorescent materials.
Department of IT Convergence, Korea National University of Transportation, Chungju 380-702, Republic of Korea.
Chan Jin
CJ
Jeong
Arup Kumer
AK
Roy
Sung Han
SH
Kim
Jung-Eun
JE
Lee
Ji Hoon
JH
Jeong
Insik
I
In
Sung Young
SY
Park
D002244:Carbon / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D031022:Mangifera / Q000737:chemistry*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D010936:Plant Extracts / Q000737:chemistry*
D005456:Fluorescent Dyes; D010936:Plant Extracts; D002244:Carbon