Preparation and optimization of quercetin-loaded liposomes for wound healing, using response surface methodology.
The basic objective of this study was to prepare quercetin-loaded liposomes by the thin film hydration method. The liposomal formulation was optimized using response surface methodology (RSM). A rotation speed of 75 rpm and a water bath temperature of 46°C were finalized as the best for optimized drug-loaded liposomal formulation. In vitro characterization of the quercetin-loaded liposomal formulation was done through some parameters including the entrapment efficiency (EE), drug release (DR), and mean particle size; the resulting values of 86.5 ± 0.42%, 76.5%, and146 nm were found to be standard characterized values respectively. It is concluded that quercetin-loaded liposomal formulations achieve sustained release of drug in wound areas.
a University Institute of Pharmacy, Pt. Ravi Shankar Shukla University , Raipur , Chhattisgarh , India.
Rajendra
R
Jangde
a University Institute of Pharmacy, Pt. Ravi Shankar Shukla University , Raipur , Chhattisgarh , India.
Deependra
D
Singh
D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D065546:Drug Liberation; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D011794:Quercetin / Q000737:chemistry* / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D008081:Liposomes; D011794:Quercetin
liposome; quercetin; response surface methodology; temperature