Helicobacter pylori and pancreatic diseases.
A possible role for Helicobacter pylori (H. pylori) infection in pancreatic diseases remains controversial. H. pylori infection with antral predomination leading to an increase in pancreatic bicarbonate output and inducing ductal epithelial cell proliferation could contribute to the development of pancreatic cancer via complex interactions with the ABO genotype, dietary and smoking habits and N-nitrosamine exposure of the host. Although the individual study data available so far is inconsistent, several meta-analyses have reported an increased risk for pancreatic cancer among H. pylori seropositive individuals. It has been suggested that H. pylori causes autoimmune pancreatitis due to molecular mimicry between H. pylori α-carbonic anhydrase (α-CA) and human CA type II, and between H. pylori plasminogen-binding protein and human ubiquitin-protein ligase E3 component n-recognin 2, enzymes that are highly expressed in the pancreatic ductal and acinar cells, respectively. Future studies involving large numbers of cases are needed in order to examine the role of H. pylori in autoimmune pancreatitis more fully. Considering the worldwide pancreatic cancer burden, as well as the association between autoimmune pancreatitis and other autoimmune conditions, a complete elucidation of the role played by H. pylori in the genesis of such conditions could have a substantial impact on healthcare.
Milutin Bulajic, University Clinical Hospital "Santa Maria della Misericordia", Piazzale S Maria della Misericordia 15, 33100 Udine, Italy.
Milutin
M
Bulajic
Milutin Bulajic, University Clinical Hospital "Santa Maria della Misericordia", Piazzale S Maria della Misericordia 15, 33100 Udine, Italy.
Nikola
N
Panic
Milutin Bulajic, University Clinical Hospital "Santa Maria della Misericordia", Piazzale S Maria della Misericordia 15, 33100 Udine, Italy.
Johannes Matthias
JM
Löhr
Autoimmune pancreatitis; Helicobacter pylori; Molecular mimicry; Pancreatic cancer; Pancreatitis