A category-free neural population supports evolving demands during decision-making.
The posterior parietal cortex (PPC) receives diverse inputs and is involved in a dizzying array of behaviors. These many behaviors could rely on distinct categories of neurons specialized to represent particular variables or could rely on a single population of PPC neurons that is leveraged in different ways. To distinguish these possibilities, we evaluated rat PPC neurons recorded during multisensory decisions. Newly designed tests revealed that task parameters and temporal response features were distributed randomly across neurons, without evidence of categories. This suggests that PPC neurons constitute a dynamic network that is decoded according to the animal's present needs. To test for an additional signature of a dynamic network, we compared moments when behavioral demands differed: decision and movement. Our new state-space analysis revealed that the network explored different dimensions during decision and movement. These observations suggest that a single network of neurons can support the evolving behavioral demands of decision-making.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.|Champalimaud Neuroscience Programme, Lisboa, Portugal.
David
D
Raposo
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Matthew T
MT
Kaufman
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Anne K
AK
Churchland
D000161:Acoustic Stimulation / Q000379:methods*; D000818:Animals; D003657:Decision Making / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods*; D011597:Psychomotor Performance / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans