Adiponectin and leptin levels in migraineurs in the Atherosclerosis Risk in Communities Study.
OBJECTIVE
To evaluate adiponectin and leptin levels in older men and women with migraine.


METHODS
Fasting total and high molecular weight (HMW) adiponectin and leptin levels were evaluated in a case-cohort study of nondiabetic older migraine and nonmigraine control participants from the ongoing, longitudinal, general population, Atherosclerosis Risk in Communities Study at visit 1 (1987-1989). A standardized headache questionnaire was completed at visit 3 (1993-1995). Logistic regression models adjusted for age, sex, race, center, body mass index, and fasting glucose were used to evaluate the association of each adipocytokine with migraine.


RESULTS
Of the 981 participants, the mean age at baseline was 52.8 years (SE 0.3); 131 fulfilled migraine criteria. Crude, mean total adiponectin levels were greater in men and women with migraine (8.1 µg/mL, SE 0.5) as compared to those without migraine (7.0 µg/mL, SE 0.2) (p = 0.031). After adjustments, the odds of migraine were increased by 88% with each SD increase in total adiponectin in men (odds ratio [OR] 1.86; 95% confidence interval [CI] 1.15, 3.01; p = 0.011), but not in women (OR 1.05; 95% CI 0.80, 1.37; p = 0.728; p interaction = 0.029). Similar results were demonstrated for HMW adiponectin. Crude and adjusted leptin levels were not associated with migraine.


CONCLUSIONS
Although crude, total adiponectin levels were higher in older men and women with migraine than controls, after adjustments, the prevalence of migraine was significantly associated with total adiponectin only in older men, suggesting the association may be confounded or absent in older women. Leptin was not associated with migraine in older men or women.
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Jennifer L
JL
Dearborn
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Andrea L C
AL
Schneider
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Rebecca F
RF
Gottesman
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Tobias
T
Kurth
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
James S
JS
Pankow
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
David J
DJ
Couper
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Kathryn M
KM
Rose
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA.
Michelle A
MA
Williams
From the Department of Neurology (J.L.D.), Yale University School of Medicine, New Haven, CT; the Department of Epidemiology (A.L.C.S.), Johns Hopkins University School of Public Health; the Department of Neurology (R.F.G., B.L.P.), Johns Hopkins University School of Medicine, Baltimore, MD; Team Neuroepidemiology (T.K.), INSERM Research Center for Epidemiology and Biostatistics (U897), Bordeaux; France College of Health Sciences (T.K.), University of Bordeaux; the School of Public Health, Division of Epidemiology and Community Health (J.S.P.), University of Minnesota, Minneapolis; the Departments of Biostatistics (D.J.C.) and Epidemiology (K.M.R.), University of North Carolina at Chapel Hill; Social and Scientific Systems, Inc. (K.M.R.), Durham, NC; and the Department of Epidemiology (M.A.W.), Harvard School of Public Health, Boston, MA. lpeterlin@jhmi.edu.
B Lee
BL
Peterlin
D052242:Adiponectin / Q000097:blood*; D050197:Atherosclerosis / Q000453:epidemiology; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D012737:Sex Factors; D011795:Surveys and Questionnaires
C499918:ADIPOQ protein, human; D052242:Adiponectin; D020738:Leptin