Hit the spleen, JAK!
In this issue of Blood, Wang et al report on the response of splenic-derived hematopoietic stem and progenitor cells from patients with myelofibrosis (MF) to the Janus kinase (JAK) inhibitor, AZD1480.
QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE;
Steven W
http://orcid.org/0000-0002-8050-6209
SW
Lane
BRIGHAM AND WOMEN'S HOSPITAL.
Ann
http://orcid.org/0000-0001-9727-8495
A
Mullally
D005260:Female; D006801:Humans; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors*; D008297:Male; D055728:Primary Myelofibrosis / Q000188:drug therapy*; D011720:Pyrazoles / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology*; D013234:Stem Cells / Q000187:drug effects*
C545606:AZD 1480; D011720:Pyrazoles; D011743:Pyrimidines; C507924:JAK2 protein, human; D053614:Janus Kinase 2