Craniocerebral injury promotes the repair of peripheral nerve injury.
The increase in neurotrophic factors after craniocerebral injury has been shown to promote fracture healing. Moreover, neurotrophic factors play a key role in the regeneration and repair of peripheral nerve. However, whether craniocerebral injury alters the repair of peripheral nerve injuries remains poorly understood. Rat injury models were established by transecting the left sciatic nerve and using a free-fall device to induce craniocerebral injury. Compared with sciatic nerve injury alone after 6-12 weeks, rats with combined sciatic and craniocerebral injuries showed decreased sciatic functional index, increased recovery of gastrocnemius muscle wet weight, recovery of sciatic nerve ganglia and corresponding spinal cord segment neuron morphologies, and increased numbers of horseradish peroxidase-labeled cells. These results indicate that craniocerebral injury promotes the repair of peripheral nerve injury.
Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Wei
W
Wang
Department of Postgraduate, Chengde Medical College, Chengde, Hebei Province, China.
Jun
J
Gao
Department of Postgraduate, Chengde Medical College, Chengde, Hebei Province, China.
Lei
L
Na
Department of Postgraduate, Chengde Medical College, Chengde, Hebei Province, China.
Hongtao
H
Jiang
Department of Anatomy, Chengde Medical College, Chengde, Hebei Province, China.
Jingfeng
J
Xue
Department of Anatomy, Chengde Medical College, Chengde, Hebei Province, China.
Zhenjun
Z
Yang
Department of Hand and Foot Surgery, Affiliated Hospital of Chengde Medical College, Chengde, Hebei Province, China.
Pei
P
Wang
craniocerebral injury; horseradish peroxidase tracer technique; nerve regeneration; nerve repair; neural regeneration; peripheral nerve; sciatic nerve; sciatic nerve injury