Incidence of and risk factors for Alzheimer's disease and mild cognitive impairment in Korean elderly.
OBJECTIVE
Knowledge of incidence rates and risk factors is essential for the development of strategies to treat patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI).


METHODS
A subpopulation of the Nationwide Survey on Dementia Epidemiology (460 Korean subjects aged ≥65 years from 2 rural and 2 urban districts) was followed up for 3.5 years. The age-specific incidence was estimated and risk factors were identified.


RESULTS
The age-standardized incidence of AD and MCI was 7.9 and 28.1 cases per 1,000 person-years, respectively. MCI was associated with a 6-fold increased risk of AD. Depression was a risk factor for AD with MCI. Age, lack of formal education, illiteracy, rural residence, and marital status were associated with the risk of AD.


CONCLUSIONS
Strategies to control modifiable risk factors should be implemented to decrease the incidence of AD.
Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea.
Jong Bin
JB
Bae
You Joung
YJ
Kim
Ji Won
JW
Han
Tae Hui
TH
Kim
Joon Hyuk
JH
Park
Seok Bum
SB
Lee
Jung Jae
JJ
Lee
Hyun Ghang
HG
Jeong
Jeong Lan
JL
Kim
Jin Hyeong
JH
Jhoo
Jong Chul
JC
Yoon
Ki Woong
KW
Kim
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology*; D060825:Cognitive Dysfunction / Q000453:epidemiology*; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors