[The genome and diabetes].
In terms of their genetic architecture monogenic diabetes and type 2 diabetes represent two extremes. Whereas each subtype of monogenic diabetes is caused by one penetrant, rare mutation in a single gene, the genetic susceptibility to type 2 diabetes can be attributed to many low-penetrant variants across the genome. At present, only 10% of the genetic susceptibility to type 2 diabetes can be explained by the hitherto identified 90 genomic loci. Here we briefly review the genetics of monogenic diabetes and type 2 diabetes and outline future directions of research within this field.
Novo Nordisk Fondens Metabolismecenter, Det Sundhedsvidenskabelige Fakultet, Københavns Universitet, Universitetsparken 1, 2100 København Ø. kristine.allin@sund.ku.dk.
Kristine Højgaard
KH
Allin
Torben
T
Hansen
Oluf Borbye
OB
Pedersen
D003920:Diabetes Mellitus / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D009154:Mutation