Hypoglycemic and anticoagulant effects of tetrapeptide Pro-Gly-Pro-Leu in hypercholesterolemia.
In rats with experimental hypercholesterolemia, 7-fold intranasal administration of the peptide Pro-Gly-Pro-Leu in a dose of 200 μg/kg body weight prevented the increase in blood glucose level and produced an anticoagulant effect.
Laboratory of Blood Protective Systems, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia, shubina.74@mail.ru.
T A
TA
Shubina
M E
ME
Grigor'eva
L A
LA
Lyapina
T Yu
TY
Obergan
N F
NF
Myasoedov
L A
LA
Andreeva
D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000008:administration & dosage* / Q000494:pharmacology; D001786:Blood Glucose; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000097:blood*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage* / Q000494:pharmacology
D000925:Anticoagulants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D009842:Oligopeptides; C551701:prolyl-glycyl-prolyl-leucine