Edaravone promotes functional recovery after mechanical peripheral nerve injury.
Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic functional index and superoxide dismutase activity of the sciatic nerve were increased, and the malondialdehyde level was decreased in animals in the edaravone group compared with those in the model group. Bcl-2 expression was increased, but Bax expression was decreased in anterior horn cells of the L4-6 spinal cord segments. These results indicated that edaravone has a neuroprotective effect following peripheral nerve injury caused by mechanical factors through alleviating free radical damage to cells and inhibiting lipid peroxidation, as well as regulating apoptosis-related protein expression.
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Teng
T
Zhang
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Zhengwei
Z
Li
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Jianli
J
Dong
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Feng
F
Nan
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Tao
T
Li
Department of Orthopedics, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Qing
Q
Yu
Bax; Bcl-2; NSFC grant; edaravone; free radical damage; lipid peroxidation; malondialdehyde; mechanical injury; nerve regeneration; neural regeneration; peripheral nerve injury; sciatic nerve injury; superoxide dismutase