Reno-invasive fungal infection presenting as acute renal failure: importance of renal biopsy for early diagnosis.
Renal zygomycosis, caused by invasive fungi, is a rare and potentially fatal infection. The patient usually presents with non-specific symptoms and renal failure. A 34-year-old male non-diabetic and without any predisposing factors for systemic fungal infection presented to the emergency department with diffuse abdominal pain, high-grade fever and acute renal failure with a serum creatinine of 6.5. A computed tomography showed bilateral diffuse globular nephromegaly. A urine smear for fungal examination showed right angle branching hyphae and kidney biopsy showed fungal hyphae within the glomeruli, tubules and interstitium. Although radiological investigations can give us a clue, the definitive diagnosis can only be made by kidney biopsy. A high index of suspicion and timely diagnosis is important for a proper management.
Department of Urology and Kidney Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Priyadarshi
P
Ranjan
Saurabh Sudhir
SS
Chipde
Saurabh
S
Vashistha
Neeraj
N
Kumari
Rakesh
R
Kapoor
D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D042241:Early Diagnosis; D017809:Fatal Outcome; D006801:Humans; D007668:Kidney / Q000382:microbiology / Q000473:pathology*; D008297:Male; D009336:Necrosis; D009392:Nephrectomy; D011237:Predictive Value of Tests; D006435:Renal Dialysis; D013997:Time Factors; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy; D020096:Zygomycosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology / Q000628:therapy
D000935:Antifungal Agents