Synthesis and characterization of a library of in-situ curing, nonswelling ethoxylated polyol thiol-ene hydrogels for tailorable macromolecule delivery.
A transesterfication reaction is used to synthesize tri-thiol-functionalized-ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume-constrained anatomical sites.
Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
Timothy M
TM
O'Shea
Alex A
AA
Aimetti
Eunha
E
Kim
Volkan
V
Yesilyurt
Robert
R
Langer
D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000627:therapeutic use; D002460:Cell Line; D002470:Cell Survival; D004058:Diffusion; D016503:Drug Delivery Systems; D020100:Hydrogels / Q000138:chemical synthesis* / Q000627:therapeutic use; D007700:Kinetics; D046911:Macromolecular Substances / Q000008:administration & dosage / Q000493:pharmacokinetics; D008422:Materials Testing; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis / Q000627:therapeutic use; D013696:Temperature; D054457:Tissue Scaffolds
D001672:Biocompatible Materials; D020100:Hydrogels; D046911:Macromolecular Substances; D011108:Polymers; C437167:poly(ethylene glycol)diacrylate; C024617:polyol; D011092:Polyethylene Glycols
candida antarctica lipase B; drug delivery; hydrogels; polymeric materials; thiol-michael addition