Pediatric nasopharyngeal carcinoma with retinal metastasis.
OBJECTIVE
To report an unusual case of nasopharyngeal carcinoma (NPC) metastatic to the lungs and retina. To our knowledge, this is the first report of retinal metastasis from NPC.


METHODS
Observational case report.


METHODS
We studied the case of a 15-year-old boy who had been recently diagnosed with metastatic NPC and was referred for evaluation of a suspicious retinal lesion in the right eye.


RESULTS
Clinical examination and fundus photography showed an amelanotic, 1-disk-area infiltration in the retina along the inferotemporal arcade that was suggestive of metastatic disease. The lesion was small and irregularly shaped by echographic examination, and a nodular area of retinal thickening was seen by optical coherence tomography. Pathologic analysis of lung biopsy and nasopharynx biopsy specimens revealed undifferentiated NPC.


CONCLUSIONS
Retinal metastases need to be considered in the differential diagnosis of patients presenting with NPC and vision changes.
From Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miller School of Medicine, and the Florida Lions Ocular Pathology Laboratory, Miami, Florida.
Armando
A
Alegret
Colleen M
CM
Cebulla
Sander R
SR
Dubovy
Lejla
L
Mutapcic
Ditte J
DJ
Hess
Timothy G
TG
Murray