Evaluation of the therapeutic response by (99m)Tc-ECD-SPET in a female with non-organic depression, generalized anxiety and heterophobia.
This is the case of a 33 years old female patient who was diagnosed with depression and heterophobia, which progressed to generalized anxiety according to the International Statistical Classification of Diseases and Health Related Problems, 10th Revision (ICD-10), Version for 2010 diagnostic criteria. The clinical symptoms of the patient were significantly improved after effective treatment. The patient underwent before and after treatment 99mTc-ethyl cysteinate dimmer ((99m)Tc-ECD) brain single-photon emission tomography (SPET). A great improvement in regional cerebral blood flow was found after treatment. In conclusion, this case highlights the value of brain perfusion SPET scan in providing objective imaging evidence of diagnosis and treatment evaluation in a patient with non-organic mental disorder.
Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Nuclear Medicine Institute of Fudan University, Shanghai Institute of Medical Imaging, Shanghai, 200032, China. shi.hongcheng@zs-hospital.sh.cn.
Yiqiu
Y
Zhang
Hongcheng
H
Shi
Beilei
B
Li
Yushen
Y
Gu
Liang
L
Cai
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects; D003545:Cysteine / Q000031:analogs & derivatives; D003863:Depression / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015609:Organotechnetium Compounds; D010698:Phobic Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D019275:Radiopharmaceuticals; D013001:Somatoform Disorders / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome
D015609:Organotechnetium Compounds; D011619:Psychotropic Drugs; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine