Controlling Enantioselectivity in Additions to Cyclic Oxocarbenium Ions via Transition Metal Catalysis.
Controlling enantioselectivity in additions to oxocarbenium ions remains a challenge in asymmetric catalysis. By catalytically generating a chiral organometallic intermediate, a copper acetylide, we have developed a novel approach for additions of carbon nucleophiles to cyclic oxocarbenium ions in high enantioselectivities and yields.
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Mary P
MP
Watson
Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.
Prantik
P
Maity
alkyne addition; asymmetric catalysis; enantioselectivity; oxocarbenium ions; transition metals