The Default Mode Network is functionally and structurally disrupted in amnestic mild cognitive impairment - a bimodal MEG-DTI study.
Over the past years, several studies on Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) have reported Default Mode Network (DMN) deficits. This network is attracting increasing interest in the AD community, as it seems to play an important role in cognitive functioning and in beta amyloid deposition. Attention has been particularly drawn to how different DMN regions are connected using functional or structural connectivity. To this end, most studies have used functional Magnetic Resonance Imaging (fMRI), Positron Emission Tomography (PET) or Diffusion Tensor Imaging (DTI). In this study we evaluated (1) functional connectivity from resting state magnetoencephalography (MEG) and (2) structural connectivity from DTI in 26 MCI patients and 31 age-matched controls. Compared to controls, the DMN in the MCI group was functionally disrupted in the alpha band, while no differences were found for delta, theta, beta and gamma frequency bands. In addition, structural disconnection could be assessed through a decreased fractional anisotropy along tracts connecting different DMN regions. This suggests that the DMN functional and anatomical disconnection could represent a core feature of MCI.
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain ; Department of Applied Physics III, Faculty of Physics, Complutense University of Madrid, Madrid 28040, Spain.
Pilar
P
Garcés
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain.
José
J
Angel Pineda-Pardo
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain.
Leonides
L
Canuet
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain ; Department of Basic Psychology II, Faculty of Psychology, Complutense University of Madrid, Madrid 28223, Spain.
Sara
S
Aurtenetxe
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain ; Department of Basic Psychology II, Faculty of Psychology, Complutense University of Madrid, Madrid 28223, Spain.
Maria Eugenia
ME
López
Neurology Department, Hospital Clínico San Carlos, Madrid 28040, Spain.
Alberto
A
Marcos
Radiology Department, Hospital Clínico San Carlos, Madrid 28040, Spain.
Miguel
M
Yus
Centre for Prevention of Cognitive Impairment, Madrid 28006, Spain.
Marcos
M
Llanero-Luque
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain.
Francisco
F
Del-Pozo
Department of Applied Physics III, Faculty of Physics, Complutense University of Madrid, Madrid 28040, Spain.
Miguel
M
Sancho
Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Centre for Biomedical Technology, Pozuelo de Alarcón, Madrid 28223, Spain ; Department of Basic Psychology II, Faculty of Psychology, Complutense University of Madrid, Madrid 28223, Spain.
Fernando
F
Maestú
D000368:Aged; D000647:Amnesia / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D058256:Brain Waves; D060825:Cognitive Dysfunction / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009415:Nerve Net / Q000473:pathology* / Q000503:physiopathology*; D012146:Rest
Alpha band; Default mode network; Diffusion tensor imaging; Functional connectivity; Magnetoencephalography; Mild cognitive impairment; Structural connectivity; Tractography