An enantioselective total synthesis of Sch-725674.
An enantioselective total synthesis of Sch-725674, a unique 14-membered macrolactone, has been accomplished in 13 steps. The step-wise dithiane alkylation served as a strategic step to assemble the upper and lower fragments of the molecule, whereas cross metathesis reaction, Yamaguchi macrolactonization and a substrate controlled stereoselective reduction are used as key steps to complete the total synthesis.
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai-400076, India. kpk@chem.iitb.ac.in.
Kota
K
Ramakrishna
Krishna P
KP
Kaliappan
D000478:Alkylation; D060326:Chemistry Techniques, Synthetic; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D018942:Macrolides; C506328:Sch 725674