Stereoselective uptake of cell-penetrating peptides is conserved in antisense oligonucleotide polyplexes.
Stereochemistry matters. A significant conceptual advancement is presented toward the understanding of how functional characteristics of delivery peptides can translate into functional characteristics of peptide-based oligoplexes.
Dept. of Biochemistry, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Geert Grooteplein 28, 6525, GA, Nijmegen, the Netherlands.
Marco Emanuele
ME
Favretto
Roland
R
Brock
D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000493:pharmacokinetics*; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D016376:Oligonucleotides, Antisense / Q000737:chemistry* / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013347:Subcellular Fractions / Q000378:metabolism*
D057846:Cell-Penetrating Peptides; D016376:Oligonucleotides, Antisense
chirality; drug delivery; endocytosis; gene therapy; oligoplexes