Expression of Bcl2 family genes in the early phase of long-term potentiation.
Expression of Bcl2 family genes was studied during the early phase of long-term potentiation in the CA1 field of rat hippocampal slices. The level of Bax mRNA and protein increased, while the content of Bcl2 mRNA and protein decreased 30 min after tetanization of the Schaffer collaterals. Our results suggest that proteins of the Bcl2 family play a role in the mechanisms of synaptic plasticity.
Construction and Technological Institute of Computer Science, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
P D
PD
Lisachev
V O
VO
Pustyl'nyak
M B
MB
Shtark
D000818:Animals; D056547:CA1 Region, Hippocampal / Q000502:physiology*; D015870:Gene Expression; D017774:Long-Term Potentiation; D008297:Male; D017208:Rats, Wistar; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism*
C494828:Bax protein, rat; D051028:bcl-2-Associated X Protein