Malignant acanthosis nigricans associated with prostate cancer: a case report.
BACKGROUND
Acanthosis nigricans is characterized by hyperpigmentation and hyperkeratosis of the skin or mucous membranes. Its malignant form is associated with internal neoplasms, especially gastric adenocarcinoma (55-61%). Coexistence with prostate cancer is uncommon. In the paraneoplastic type of this dermatosis, the skin and mucous lesions are characteristically of more sudden onset and more severe than those in the benign form. The efficacy of various treatment strategies remains disappointing.


METHODS
We here report a case of 66-year-old Caucasian patient with metastatic prostate cancer and a mild form of acanthosis nigricans that preceded the diagnosis of malignancy and resolved with chemotherapy in parallel with the prostate cancer. The dermatosis recurred when the prostate cancer progressed.


CONCLUSIONS
Concurrent acanthosis nigricans and prostate cancer is rare, and few such cases have been reported. Anti-tumor therapy occasionally results in regression of this dermatosis. Underlying malignant disease should be suspected in individuals with elderly-onset of acanthosis nigricans.
Department of Chemotherapy, Medical University of Lodz, Paderewskiego 4, 93-509 Lodz, Poland. zuz.ka@interia.pl.
Joanna
J
Kubicka-Wołkowska
Sylwia
S
Dębska-Szmich
Maja
M
Lisik-Habib
Marcin
M
Noweta
Piotr
P
Potemski
D000052:Acanthosis Nigricans / Q000150:complications*; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000556:secondary; D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence
D000970:Antineoplastic Agents