Fifteen years of kidney biopsies in children: a single center in Egypt.
This study retrospectively investigates the indications and results of renal biopsy in children to determine the patterns of childhood kidney disease in a single tertiary children's hospital in Egypt. We included all the patients who underwent ultrasound-guided renal biopsy from 1998 to 2012. All the kidney biopsies were studied under light microscopy, while immunofluorescence and electron microscopy were performed when indicated. A total of 1246 renal biopsies were performed over 15 years, on 1096 patients. The mean age of the patients at the time of biopsy was 9.2±3.7 years. The main indication for a biopsy was the steroid-resistant nephrotic syndrome (n=354, 28.4%), followed by the atypical nephrotic syndrome (n=250, 20.1%), and renal abnormalities in the systemic diseases (n=228, 18.3 %). In the 1226 pathologically diagnosed specimens, primary glomerulonephritis was the most common finding (n=826, 67.4%), followed by secondary glomerulonephritis (n=238, 19.4%). The most common causes of primary glomerulonephritis were Minimal Change Disease (MCD) (n=267, 21.8%), diffuse proliferative glomerulonephritis (n=188, 15. 3%), and focal proliferative glomerulonephritis (n=164, 13.3%). Lupus nephritis (n=209, 17%) was the most common cause of secondary glomerulonephritis. We conclude that the steroid-resistant nephrotic syndrome was the most frequent indication for biopsy and minimal change disease was the most common histopathological finding in our population.
Ashraf
A
Bakr
Pediatric Nephrology and Dialysis Unit, Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt.
Riham
R
Eid
Amr
A
Sarhan
Ayman
A
Hammad
Ahmed Mahmoud
AM
El-Refaey
Atef
A
El-Mougy
Mohammed Magdy
MM
Zedan
Fatma
F
ElHusseini
Ashraf Abd
AA
El-Rahman
D000293:Adolescent; D000367:Age Factors; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005455:Fluorescent Antibody Technique; D006776:Hospitals, Pediatric; D006801:Humans; D007223:Infant; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D009402:Nephrosis, Lipoid / Q000175:diagnosis / Q000473:pathology; D009404:Nephrotic Syndrome / Q000151:congenital / Q000175:diagnosis / Q000473:pathology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D062606:Tertiary Care Centers