Efficient Cu(OTf)2-catalyzed synthesis of novel and diverse 2,3-dihydroquinazolin-4(1H)-ones.
An efficient one-pot synthesis of various 2,3-dihydroquinazolin-4(1H)-one derivatives was accomplished using Cu(OTf)2-catalyzed multi-component reactions between isatoic anhydride, ketones, and amines. The method has several significant advantages; mild reaction conditions, easy handling, and efficiency of catalyst.
School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749, Republic of Korea.
Xiaoyan
X
Zhu
So Rang
SR
Kang
Likai
L
Xia
Jihye
J
Lee
Nagaraj
N
Basavegowda
Yong Rok
YR
Lee
D000588:Amines / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D008958:Models, Molecular; D010078:Oxazines / Q000737:chemistry; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry*
D000588:Amines; D007659:Ketones; D008698:Mesylates; D010078:Oxazines; D052999:Quinazolinones; D003300:Copper; C012077:trifluoromethanesulfonic acid; C037902:isatoic anhydride