High-grade urothelial carcinoma, plasmacytoid variant, of the renal pelvis with osteoclast-like giant cells and focal rhabdoid features.
In this article, we present a rare case of renal pelvic carcinoma. The imaging examination of a 75-year-old Japanese man disclosed the left renal pelvic tumor. The histological examination showed the finding of predominant undifferentiated discohesive mononuclear cells with abundant osteoclast-like giant cells and a minor component of papillary urothelial carcinoma. Rhabdoid morphology was focally seen. Immunohistochemically, mononuclear cells were focally positive for thrombomodulin and showed a high MIB-1 index, whereas osteoclast-like giant cells were positive for CD68. Urologists should bear in mind that a rare association of high-grade urothelial carcinoma, plasmacytoid variant, with osteoclast-like giant cells and focal rhabdoid features may occur in the renal pelvis.
Naoto Kuroda, MD, Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi 2-13-51, Kochi City, Kochi 780-8562, Japan, tel. +81-88-822-1201 ext. 1610, fax +81-88-822-1056, e-mail: kurochankochi@yahoo.co.jp.
Naoto
N
Kuroda
Takushi
T
Naroda
Masato
M
Tamura
Delia
D
Perez-Montiel
Michal
M
Michal
Ondrej
O
Hes
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D015726:Giant Cells / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D007682:Kidney Pelvis / Q000473:pathology*; D008297:Male; D060787:Neoplasm Grading; D010010:Osteoclasts / Q000473:pathology
D014408:Biomarkers, Tumor