The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome.
OBJECTIVE
To evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI).


METHODS
Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n = 12), II (non-eutrophic without PCOS, n = 10), III (eutrophic with PCOS, n = 8) and IV (eutrophic without PCOS, n = 10) being non-eutrophic, the overweight and obese women with BMI > 25 kg/m2 and eutrophic women with BMI < 24.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR.


RESULTS
PCOS patients showed increased levels of CRP (p < 0.01) and HOMA-IR (p < 0.01). When divided by BMI, both non-eutrophicad eutrophic PCOS showed increased CRP levels (p < 0.01) and HOMA-IR (p < 0.01). There were no differences in TNF-α and IL-6 levels between groups.


CONCLUSIONS
In the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass.
Graduate Program in Pharmaceutical Sciences - CCS , Natal, RN , Brazil .
Ana Celly
AC
Souza Dos Santos
Nayara Pereira
NP
Soares
Eduardo Caldas
EC
Costa
Joceline Cássia Ferrezini
JC
de Sá
George Dantas
GD
Azevedo
Telma Maria Araújo Moura
TM
Lemos
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D015850:Interleukin-6 / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
Cytokines; inflammation; insulin resistance; nutritional status; obesity; ovary; polycystic ovary syndrome