Natural killer cell regulation - beyond the receptors.
Natural killer (NK) cells are lymphocytes that are important for early and effective immune responses against infections and cancer. In the last 40 years, many receptors, their corresponding ligands and signaling pathways that regulate NK cell functions have been identified. However, we now know that additional processes, such as NK cell education, differentiation and also the formation of NK cell memory, have a great impact on the reactivity of these cells. Here, we summarize the current knowledge about these modulatory processes.
IfADo - Leibniz Research Centre for Working Environment and Human Factors Ardeystrasse 67, 44139 Dortmund Germany.
Carsten
C
Watzl
IfADo - Leibniz Research Centre for Working Environment and Human Factors Ardeystrasse 67, 44139 Dortmund Germany.
Doris
D
Urlaub
IfADo - Leibniz Research Centre for Working Environment and Human Factors Ardeystrasse 67, 44139 Dortmund Germany.
Frank
F
Fasbender
IfADo - Leibniz Research Centre for Working Environment and Human Factors Ardeystrasse 67, 44139 Dortmund Germany.
Maren
M
Claus