Genomic imprinting in farm animals.
The mouse is the first species in which genomic imprinting was studied. Imprinting research in farm species has lagged behind owing to a lack of sequencing and genetic background information, as well as long generation intervals and high costs in tissue collection. Since the creation of Dolly, the first cloned mammal from an adult sheep, studies on genomic imprinting in domestic species have accelerated because animals from cloning and other assisted reproductive technologies exhibit phenotypes of imprinting disruptions. Although this review focuses on new developments in farm animals, most of the imprinting mechanism information was derived from the mouse.
Department of Animal Science, Center for Regenerative Biology, University of Connecticut, Storrs, Connecticut 06269-4163; email: xiuchun.tian@uconn.edu.
Xiuchun Cindy
XC
Tian
D000818:Animals; D019976:Cloning, Organism; D018392:Genomic Imprinting / Q000235:genetics* / Q000502:physiology*; D058751:Livestock / Q000235:genetics* / Q000502:physiology*
cattle; epigenetics; genomic imprinting; horses; pigs; sheep