Increase of circulating stromal cell-derived factor-1 in heart failure patients.
BACKGROUND
The role of circulating stromal cell-derived factor-1 (SDF-1) in heart failure (HF) has not been defined. The aim of this study was to examine the circulating SDF-1 levels in hospitalized heart failure (HHF) patients.


METHODS
Circulating SDF-1 and other clinical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP), and echocardiographic parameters, were measured in HHF patients (n = 69) and healthy control subjects (n = 35).


RESULTS
The circulating SDF-1 level was significantly greater in patients with HF (5,101 ± 1,977 pg/ml) compared with the control subjects (1,879 ± 1,417 pg/ml; p < 0.001). Circulating SDF-1 levels were positively correlated with NT-proBNP (r = 0.46 p < 0.001) and CRP (r = 0.53 p < 0.001) levels, and negatively correlated with left ventricular ejection fraction values (r = - 0.41, p < 0.001).


CONCLUSIONS
The level of circulating SDF-1 increases in HHF patients.
Key Laboratory of Myocardial Ischemia Mechanism and Treatment, Chinese Ministry of Education, Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, 150086, Harbin, Heilongjiang Province, China.
K
K
Liu
S
S
Yang
M
M
Hou
T
T
Chen
J
J
Liu
B
B
Yu
D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D054377:Chemokine CXCL12 / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D015415:Biomarkers; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12