Rebound neovascularization during bevacizumab therapy.
OBJECTIVE
To present two cases of rebound neovascularization after bevacizumab treatment.


METHODS
Observational, retrospective case report. A 42-year-old male patient with proliferative diabetic retinopathy and a 68-year-old man with central retinal vein occlusion received treatment with panretinal photocoagulation and intravitreal bevacizumab.


RESULTS
Both patients showed significant improvement with regression of neovascular vessels after treatment. Nevertheless, on cessation of treatment because of loss to follow-up, both presented with massive neovascularization. This was significantly more severe than the initial presentation.


CONCLUSIONS
After initial suppression of vascular endothelial growth factor by bevacizumab, a rebound phenomenon of neovascularization can occur.
José M
JM
Garcia-González
Maria
M
Berrocal