Secure Secondary Use of Clinical Data with Cloud-based NLP Services. Towards a Highly Scalable Research Infrastructure.
OBJECTIVE
The secondary use of clinical data provides large opportunities for clinical and translational research as well as quality assurance projects. For such purposes, it is necessary to provide a flexible and scalable infrastructure that is compliant with privacy requirements. The major goals of the cloud4health project are to define such an architecture, to implement a technical prototype that fulfills these requirements and to evaluate it with three use cases.


METHODS
The architecture provides components for multiple data provider sites such as hospitals to extract free text as well as structured data from local sources and de-identify such data for further anonymous or pseudonymous processing. Free text documentation is analyzed and transformed into structured information by text-mining services, which are provided within a cloud-computing environment. Thus, newly gained annotations can be integrated along with the already available structured data items and the resulting data sets can be uploaded to a central study portal for further analysis.


RESULTS
Based on the architecture design, a prototype has been implemented and is under evaluation in three clinical use cases. Data from several hundred patients provided by a University Hospital and a private hospital chain have already been processed.


CONCLUSIONS
Cloud4health has shown how existing components for secondary use of structured data can be complemented with text-mining in a privacy compliant manner. The cloud-computing paradigm allows a flexible and dynamically adaptable service provision that facilitates the adoption of services by data providers without own investments in respective hardware resources and software tools.
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J
Christoph
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L
Griebel
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Leb
I
I
Engel
F
F
Köpcke
D
D
Toddenroth
H-U
HU
Prokosch
J
J
Laufer
K
K
Marquardt
Dr. Martin Sedlmayr, Lehrstuhl für Medizinische Informatik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Wetterkreuz 13, 91058 Erlangen, Germany, E-mail: martin.sedlmayr@fau.de.
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Sedlmayr
D000067917:Cloud Computing; D057225:Data Mining; D006801:Humans; D020407:Internet; D008490:Medical Informatics; D009323:Natural Language Processing; D018907:Privacy; D012985:Software Design
Cloud-computing; natural language processing; privacy; secondary use; software design; text-mining