A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.
Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK).
Richard J
RJ
Ingham
Claudio
C
Battilocchio
Daniel E
DE
Fitzpatrick
Eric
E
Sliwinski
Joel M
JM
Hawkins
Steven V
SV
Ley
D000547:Amantadine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation*; D004867:Equipment Design
D002264:Carboxylic Acids; C070094:2-aminoadamantane; D000547:Amantadine
continuous processing; flow reactors; integrated systems; synthetic methods