Changes in coagulation and fibrinolytic indices in women with polycystic ovarian syndrome undergoing controlled ovarian hyperstimulation.
Background. Polycystic ovarian syndrome (PCOS) women undergoing in vitro fertilization and embryo transfer (IVF-ET) treatment always attain a low cumulative pregnancy rate disaccording with the satisfactory number of oocytes. Objective. We aim to evaluate the status of coagulation and fibrinolytic system in PCOS patients undergoing controlled ovarian hyperstimulation (COH) process. Method. Of the 97 women, 30 patients with PCOS composed the study group; 67 women of child-bearing age with normal endocrine function composed the control group. All participants underwent GnRH agonist standard long protocol, and plasma HCY, FVIII, FX, and D-dimer levels as well as hormone parameters were measured at day of full downregulation, hCG priming, and embryos transfer. Results. On day of full downregulation, FX levels were significantly higher in PCOS group (P < 0.01). On hCG priming day, FX and estrogen levels in PCOS group were higher than in the control group and FVIII levels were significantly lower on day of embryos transfer whereas FX and E2 levels were significantly higher in PCOS group. Conclusion. Hypercoagulable state during peri-implantation phase would probably lead to poor microcirculation of endometrium and be one of the most important disadvantages of successful implantation and subsequent clinical pregnancy.
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Ying
Y
Huang
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Yong
Y
Zhao
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Ling
L
Yan
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Yun-Hai
YH
Chuai
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Ling-Ling
LL
Liu
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Yi
Y
Chen
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Min
M
Li
Department of Reproductive Center, Navy General Hospital, Fucheng Road, Beijing 100048, China ; Department of Obstetrics and Gynecology, Navy General Hospital, Fucheng Road, Beijing 100048, China.
Ai-Ming
AM
Wang