Osteoconductivity and osteoinductivity of porous hydroxyapatite coatings deposited by liquid precursor plasma spraying: in vivo biological response study.
The beneficial effect of a porous structure on the biological functions of calcium phosphate bulk ceramic or scaffold has been well documented. Nevertheless, the effect of a porous structure on the in vivo performance of hydroxyapatite (HA) coatings has been rarely reported, partly due to the difficulty in synthesizing porous HA coatings suitable for commercial applications. In this study, we have carried out a systematic in vivo study of porous HA-coated Ti implants (with and without surface modification) prepared by the liquid precursor plasma spraying process, in terms of its osteoconductivity and osteoinductivity. The results suggest the clear advantage of the porous structure over the dense structure, despite the pore structure (about 48% porosity and less than 100 μm average pore size) being far from the ideal pore structure reported for bulk ceramic. The porous HA-coated implant significantly promotes early bone ingrowth at the pre-generated defective region, and early fixation at the bone-implant interface, especially at early implantation time (one month), showing about 120% and 40% increases respectively over those of the dense HA-coated implants prepared by the conventional atmospheric plasma spraying process. Moreover, the porous structure can be readily used to incorporate collagen/rh-BMP2, which demonstrates clear ectopic bone formation. Overall, the results suggest the augmentation of bone ingrowth is significant for HA coatings with a porous structure, which is critical for the early fixation and long-term stability of medical implants.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, People's Republic of China. State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology, Mianyang 621010, People's Republic of China.
Yi
Y
Huang
Jing
J
He
Lu
L
Gan
Xiaoguang
X
Liu
Yao
Y
Wu
Fang
F
Wu
Zhong-wei
ZW
Gu
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D055396:Bone Morphogenetic Protein 2 / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D011994:Recombinant Proteins / Q000737:chemistry; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D003094:Collagen; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium