Increased serum levels of macrophage inflammatory protein-3α and cystatin a predict a poor prognosis of nasopharyngeal carcinoma.
This study was aimed to investigate the roles of serum macrophage inflammatory protein-3α (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) prognosis.The serum levels of MIP-3α and cystatin A in 140 primary NPC patients without distant metastasis were detected by enzyme-linked immunosorbent assay before and after treatment. The results were compared with those in 100 healthy controls. The log-rank test was used to compare survival curves of the 2 groups. Multivariate analysis of prognostic factors used Cox proportional hazards regression model.Serum levels of MIP-3α and cystatin A in pretreatment patients with NPC were higher than those in healthy controls. Concentrations of these 2 factors in the majority of patients after the therapy decreased to control level. Patients with high serum level of MIP-3α and cystatin A before treatment had poorer overall survival (OS), local recurrence-free survival, and distant metastasis-free survival than the ones with low level. In addition, serum pretreatment MIP-3α and cystatin A levels were independent prognostic factors for OS and distant metastasis-free survival of NPC patients; serum posttreatment MIP-3α and cystatin A levels were independent prognostic factors of local recurrence-free survival.Our results revealed that serum MIP-3α and cystatin A may be promising candidate prognostic factors for NPC, and higher serum levels of MIP-3α and cystatin A correlate with shorter probability of OS, local recurrence, and distant metastasis.
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism (YC, JL, AL, YZ, HZ, MT); Clinical Laboratory (YC, JL, AL); Department of Radiation Oncology (WZ, JG), Wuzhou Red Cross Hospital, Wuzhou, Guangxi; Second People's Hospital of Zhuhai (WW), Zhuhai, Guangdong; and College of Life Science and Bioengineering (MT), Beijing University of Technology, Beijing, China.
Yonglin
Y
Cai
Jun
J
Li
Aiying
A
Lu
Weiming
W
Zhong
Jianquan
J
Gao
Yuming
Y
Zheng
Hong
H
Zeng
Wei
W
Wang
Minzhong
M
Tang
D000328:Adult; D000368:Aged; D002277:Carcinoma; D054418:Chemokine CCL20 / Q000097:blood*; D055312:Cystatin A / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000097:blood* / Q000401:mortality / Q000556:secondary / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D055815:Young Adult
C108355:CCL20 protein, human; D054418:Chemokine CCL20; D055312:Cystatin A