A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogenParastagonospora nodorum.
The model pathogenParastagonospora nodorumis a necrotroph and the causal agent of the wheat disease Septoria nodorum blotch (SNB). The sequencedP. nodorumgenome has revealed that the fungus harbours a large number of secondary metabolite genes. Secondary metabolites are known to play important roles in the virulence of plant pathogens, but limited knowledge is available about the SM repertoire of this wheat pathogen. Here, we review the secondary metabolites that have been isolated fromP. nodorumand related species of the same genus and provide an in-depth genome-wide overview of the secondary metabolite gene clusters encoded in theP. nodorumgenome. The secondary metabolite gene survey reveals thatP. nodorumis capable of producing a diverse range of small molecules and exciting prospects exist for discovery of novel virulence factors and bioactive molecules.
Plant Sciences Division, Research School of Biology, The Australian National University , Canberra , 0200 , Australia.
Yit-Heng
YH
Chooi
Plant Sciences Division, Research School of Biology, The Australian National University , Canberra , 0200 , Australia.
Mariano Jordi
MJ
Muria-Gonzalez
Plant Sciences Division, Research School of Biology, The Australian National University , Canberra , 0200 , Australia.
Peter S
PS
Solomon
Parastagonospora nodorum; nonribosomal peptide synthetase; plant pathogen; polyketide synthase; secondary metabolites; terpene synthase