Tight coordination of growth and differentiation between germline and soma provides robustness for drosophila egg development.
Organs often need to coordinate the growth of distinct tissues during their development. Here, we analyzed the coordination between germline cysts and the surrounding follicular epithelium during Drosophila oogenesis. Genetic manipulations of the growth rate of both germline and somatic cells influence the growth of the other tissue accordingly. Growth coordination is therefore ensured by a precise, two-way, intrinsic communication. This coordination tends to maintain constant epithelial cell shape, ensuring tissue homeostasis. Moreover, this intrinsic growth coordination mechanism also provides cell differentiation synchronization. Among growth regulators, PI3-kinase and TORC1 also influence differentiation timing cell-autonomously. However, these two pathways are not regulated by the growth of the adjacent tissue, indicating that their function reflects an extrinsic and systemic influence. Altogether, our results reveal an integrated and particularly robust mechanism ensuring the spatial and temporal coordination of tissue size, cell size, and cell differentiation for the proper development of two adjacent tissues.
GReD Laboratory, UMR CNRS 6293 - Clermont Université - INSERM U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France.
Caroline
C
Vachias
GReD Laboratory, UMR CNRS 6293 - Clermont Université - INSERM U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France.
Cornelia
C
Fritsch
GReD Laboratory, UMR CNRS 6293 - Clermont Université - INSERM U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France.
Pierre
P
Pouchin
GReD Laboratory, UMR CNRS 6293 - Clermont Université - INSERM U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France.
Olivier
O
Bardot
GReD Laboratory, UMR CNRS 6293 - Clermont Université - INSERM U1103, Faculté de Médecine, Place Henri Dunant, 63000 Clermont-Ferrand, France. Electronic address: vincent.mirouse@udamail.fr.
Vincent
V
Mirouse
D053687:Adult Stem Cells / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004330:Drosophila / Q000378:metabolism / Q000502:physiology*; D004847:Epithelial Cells / Q000166:cytology* / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism; D009866:Oogenesis; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism
D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D019869:Phosphatidylinositol 3-Kinases; D058570:TOR Serine-Threonine Kinases