Dynamics of Magnetic Nanoparticle-Based Contrast Agents in Tissues Tracked Using Magnetomotive Optical Coherence Tomography.
Magnetomotive optical coherence tomography (MM-OCT) is an important tool for the visualization and quantitative assessment of magnetic nanoparticles in tissues. In this study, we demonstrate the use of MM-OCT for quantitative measurement of magnetic iron oxide nanoparticle transport and concentration inex vivomuscle, lung, and liver tissues. The effect of temperature on the dynamics of these nanoparticles is also analyzed. We observe that the rate of transport of nanoparticles in tissues is directly related to the elasticity of tissues, and describe how the origin of the MM-OCT signal is associated with nanoparticle binding. These results improve our understanding of how iron oxide nanoparticles behave dynamically in biological tissues, which has direct implications for medical and biological applications of targeted nanoparticles for contrast enhancement and therapy.
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
Renu
R
John
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801 USA.
Eric J
EJ
Chaney
Biophotonics Imaging Laboratory, Beckman Institute for Advanced Science and Technology, and the Departments of Electrical and Computer Engineering, Bioengineering, and Medicine, University of Illinois Urbana-Champaign, Urbana, IL 61801 USA.
Stephen A
SA
Boppart
Iron oxide; magnetic nanoparticles (MNPs); magnetomotive; optical coherence tomography (OCT)