Preclinical evaluation of the immunomodulatory lymphocyte trafficking drug FTY720 for HIV prevention in the female genital mucosa of macaques.
FTY720 has been shown to reduce inflammatory cytokines and immune cells in the genital mucosa of macaques. This pilot study examined the ability of FTY720 to inhibit HIV acquisition. Systemic treatment with FTY720 failed to prevent or delay vaginal SHIV transmission.
Monica
M
Morris
Rachael D
RD
Aubert
Katherine
K
Butler
Tara
T
Henning
James
J
Mitchell
Leecresia
L
Jenkins
David
D
Garber
Janet
J
McNicholl
Ellen N
EN
Kersh
D000282:Administration, Intravaginal; D061605:Administration, Intravenous; D000818:Animals; D002584:Cervix Uteri / Q000737:chemistry / Q000276:immunology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D000068876:Fingolimod Hydrochloride; D015658:HIV Infections / Q000517:prevention & control; D056747:Immunomodulation; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D008254:Macaca nemestrina; D009092:Mucous Membrane / Q000737:chemistry / Q000276:immunology; D010865:Pilot Projects; D011409:Propylene Glycols / Q000494:pharmacology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control; D015302:Simian Immunodeficiency Virus / Q000187:drug effects*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014621:Vagina / Q000737:chemistry / Q000276:immunology*
D007166:Immunosuppressive Agents; D011409:Propylene Glycols; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine