2-(2-nitrovinyl)furan promotes oxidation of cellular proteins, lipids, and DNA of male rat liver and kidney.
The effect of 2-(2-nitrovinyl)furan on the redox status of male rat liver and kidney was evaluated. Twenty male rats were randomized into four groups; group A received olive oil and groups B, C, and D rats received 12.5, 25, and 50 mg/kg bodyweight of 2-(2-nitrovinyl)furan intraperitoneally, daily at 24 h interval, respectively, for 14 days. 2-(2-Nitrovinyl)furan significantly reduced (P < 0.05) alkaline phosphatase, alanine, and aspartate aminotransferase activities in male rat liver and kidney with a corresponding increase in serum. The activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and levels of reduced glutathione/glutathione disulfide (GSSG) ratio in the liver and kidney of 2-(2-nitrovinyl)furan-treated rats decreased significantly (P < 0.05). In contrast, GSSG, protein carbonyl, conjugated dienes, lipid hydroperoxides, malondialdehyde, and fragmented DNA (%) in 2-(2-nitrovinyl)furan-treated rats increased significantly (P < 0.05). Overall, data from this study revealed that 2-(2-nitrovinyl)furan exhibited its toxic effect by suppressing or depleting the antioxidant systems.
Antioxidants, Free Radicals, Functional Foods and Toxicology Research Laboratory, Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria. ajiboyeyong@yahoo.com.
T O
TO
Ajiboye
K A
KA
Alabi
F A
FA
Ariyo
A O
AO
Adeleye
O B
OB
Ojewuyi
A
A
Balogun
T O
TO
Sunmonu
D000818:Animals; D002374:Catalase / Q000378:metabolism; D004247:DNA / Q000737:chemistry; D053938:DNA Fragmentation / Q000187:drug effects*; D005663:Furans / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D050050:Protein Carbonylation / Q000187:drug effects*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D014753:Vinyl Compounds / Q000633:toxicity*
D005663:Furans; D014753:Vinyl Compounds; C517823:trans-2-(2-nitrovinyl)furan; D004247:DNA; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione
DNA Fragmentation; Lipid Peroxidation; Nitrovinyl Furan; Protein Oxidation; Redox Imbalance