Tandem synthesis of 3-halo-5-substituted isoxazoles from 1-copper(I) alkynes and dihaloformaldoximes.
A tandem synthesis of 3-halo-5-substituted isoxazoles has been developed from 1-copper(I) alkynes and dihaloformaldoximes under base-free conditions. Thus, 1,3-dipolar cycloaddition and all its drawbacks can now be avoided completely.
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Wenwen
W
Chen
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Bo
B
Wang
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Nan
N
Liu
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Dayun
D
Huang
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Xinyan
X
Wang
Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
Yuefei
Y
Hu
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis* / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*
D000480:Alkynes; D006842:Hydrocarbons, Brominated; D007555:Isoxazoles; D010091:Oximes; C484470:formaldoxime; D003300:Copper