Oocyte ageing and epigenetics.
It has become a current social trend for women to delay childbearing. However, the quality of oocytes from older females is compromised and the pregnancy rate of older women is lower. With the increased rate of delayed childbearing, it is becoming more and more crucial to understand the mechanisms underlying the compromised quality of oocytes from older women, including mitochondrial dysfunctions, aneuploidy and epigenetic changes. Establishing proper epigenetic modifications during oogenesis and early embryo development is an important aspect in reproduction. The reprogramming process may be influenced by external and internal factors that result in improper epigenetic changes in germ cells. Furthermore, germ cell epigenetic changes might be inherited by the next generations. In this review, we briefly summarise the effects of ageing on oocyte quality. We focus on discussing the relationship between ageing and epigenetic modifications, highlighting the epigenetic changes in oocytes from advanced-age females and in post-ovulatory aged oocytes as well as the possible underlying mechanisms.
Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA.
Zhao-Jia
ZJ
Ge
Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA.
Heide
H
Schatten
Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA zcl6086@gmail.com sunqy@ioz.ac.cn.
Cui-Lian
CL
Zhang
Reproductive Medicine CenterHenan Provincial People's Hospital, #7 Weiwu Road, Jinshui District, Zhengzhou, Henan Province 450003, People's Republic of ChinaState Key Laboratory of Reproductive BiologyInstitute of Zoology, Chinese Academy of Sciences, #1 Beichen West Road, Chaoyang District, Beijing 100101, People's Republic of ChinaReproductive Medicine CenterPeople's Hospital of Zhengzhou University, Zhengzhou, Henan Province 450003, People's Republic of ChinaDepartment of Veterinary PathobiologyUniversity of Missouri, Columbia, Missouri 65211, USA zcl6086@gmail.com sunqy@ioz.ac.cn.
Qing-Yuan
QY
Sun
D000375:Aging / Q000502:physiology*; D044127:Epigenesis, Genetic; D005260:Female; D006801:Humans; D008423:Maternal Age; D009865:Oocytes / Q000502:physiology*; D011247:Pregnancy