Cell and molecular biology of epidermal growth factor receptor.
The epidermal growth factor receptor (EGFR) has been one of the most intensely studied cell surface receptors due to its well-established roles in developmental biology, tissue homeostasis, and cancer biology. The EGFR has been critical for creating paradigms for numerous aspects of cell biology, such as ligand binding, signal transduction, and membrane trafficking. Despite this history of discovery, there is a continual stream of evidence that only the surface has been scratched. New ways of receptor regulation continue to be identified, each of which is a potential molecular target for manipulating EGFR signaling and the resultant changes in cell and tissue biology. This chapter is an update on EGFR-mediated signaling, and describes some recent developments in the regulation of receptor biology.
Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Brian P
BP
Ceresa
Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.
Joanne L
JL
Peterson
D000818:Animals; D001665:Binding Sites; D066246:ErbB Receptors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D009154:Mutation; D010766:Phosphorylation; D011487:Protein Conformation; D055503:Protein Multimerization; D021381:Protein Transport; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D054875:Ubiquitination
D008024:Ligands; D066246:ErbB Receptors
Cancer; Endocytic trafficking; Epidermal growth factor receptor; Epithelial cells; ErbB family; Receptor tyrosine kinase