Leptin, a mediator of cardiac damage associated with obesity.
Obesity and excess of adipose tissue are associated with the development of cardiovascular risk factors such as diabetes, hypertension, and hyperlipidemia. At the cardiac level, various morphological adaptations in cardiac structure and function occur in obese individuals. Different mechanisms linking obesity to these modifications have been postulated. Adipose tissue and epicardial fat releases a large number of cytokines and bioactive mediators such as leptin. Leptin circulates in proportion to body fat mass, thus serving as a satiety signal and informing central metabolic control centers as to the status of peripheral energy stores. It participates in numerous other functions both peripherally and centrally, as indicated by the wide distribution of leptin and the different isoforms of its receptor in different tissues including the heart. This hormone has distinct effects on the reproductive, cardiovascular, and immune systems; however, its role in the heart could mediate wide physiological effects observed in obese individuals. Oxidative stress is associated with obesity and may be considered to be a unifying mechanism in the development of obesity-related comorbidities. It has been reported that obesity may induce systemic oxidative stress; in turn, oxidative stress is associated with an irregular production of adipokines. We herein review the current knowledge of cardiac effects of leptin and the possible mechanisms that are involved, including oxidative stress that plays a major role in the development of cardiovascular damage.
E
E
Martínez-Martínez
R
R
Jurado-López
P
P
Cervantes-Escalera
V
V
Cachofeiro
M
M
Miana
D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D018384:Oxidative Stress; D054411:Receptors, Leptin / Q000378:metabolism
D020738:Leptin; D054411:Receptors, Leptin