Profile of memory impairment as a prognostic marker in amnestic mild cognitive impairment.
We aimed to evaluate whether recognition memory can be used to identify patients with amnestic mild cognitive impairment (aMCI) at greater risk for converting to dementia. We recruited 2172 aMCI patients. They were divided into two groups: aMCI with impaired recall but normal recognition (aMCI-IRNR) vs aMCI with impaired recall and impaired recognition (aMCI-IRIR). We compared demographic findings and neuropsychological performance and illustrated the difference in converting to dementia between the two groups. Study subjects consisted of 1022 (47.0%) patients with aMCI-IRNR and 1150 (53.0%) patients with aMCI-IRIR. In most neuropsychological tests except for digit span forward, patients with aMCI-IRIR were more impaired than patients with aMCI-IRNR even after adjustment of their age and sex. Cox analysis adjusting age and gender revealed that the risk of dementia conversion was higher in patients with aMCI-IRIR than in patients with aMCI-IRNR [hazard ratio (HR)=1.400, 95% CI 1.009-1.943; P=0.044]. This study showed that recognition memory can be used to identify patients with amnestic mild cognitive impairment (aMCI) at greater risk for converting to dementia.
Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Manyong
M
Lee
Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Tae Sung
TS
Lim
Regional Clinical Trial Center, Ajou University Medical Center, Suwon, Republic of Korea; Department of Biostatistics, Yonsei University College of Medicine, Seoul, Republic of Korea.
Hyun Young
HY
Lee
Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea. Electronic address: symoon.bv@gmail.com.
So Young
SY
Moon
D000368:Aged; D000369:Aged, 80 and over; D003071:Cognition; D060825:Cognitive Dysfunction / Q000150:complications* / Q000523:psychology*; D003704:Dementia / Q000209:etiology* / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008568:Memory; D011939:Mental Recall; D009483:Neuropsychological Tests; D011379:Prognosis; D012307:Risk Factors
Alzheimer's disease; Amnestic; Dementia; Mild cognitive impairment; Recall; Recognition