The progress of inflammation and oxidative stress in patients with chronic kidney disease.
BACKGROUND
The variations and their correlation of inflammation and oxidative stress in chronic kidney disease (CKD) have not been thoroughly understood.


METHODS
Biomarkers of inflammation and oxidative stress were measured in a cohort of 176 patients with CKD ranging from stage 1 to 5 and 67 healthy controls. Correlation analysis in levels between inflammation and oxidative stress was also performed with estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula. Concentrations of serum creatinine (Scr), hs-CRP (hypersensitive C reactive protein) and MDA (malondialdehyde) of these participants were measured again after 12 month follow-up.


RESULTS
In the present study, with the development of CKD, serum levels of hs-CRP, interleukin-6 (IL-6) and MDA were significantly increased, and the serum levels of SOD (superoxide dismutase) and GSH-PX (glutathione peroxidase) were significantly decreased in these participants. eGFR was inversely associated with MDA and positively with SOD and GSH-PX when adjusting for age and hypertension therapy. IL-6 and hs-CRP were positively correlated with MDA, and negatively associated with SOD and GSH-PX. Notably, after 12-month follow-up, the increase in Scr was positively associated with the increase in hs-CRP (p < 0.01) and MDA (p < 0.05), respectively.


CONCLUSIONS
Inflammation and oxidative stress interacted with each other and played pivotal roles in the development of CKD. Variation in eGFR was parallel with the changes of oxidative stress and inflammation when CKD developing.
Department of Nephrology, Second Affiliated Hospital, Nanchang University , Nanchang , China and.
Gaosi
G
Xu
Kaiping
K
Luo
Huixin
H
Liu
Tianlun
T
Huang
Xiangdong
X
Fang
Weiping
W
Tu
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D051436:Renal Insufficiency, Chronic / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000097:blood*
D015415:Biomarkers; D015850:Interleukin-6; D008315:Malondialdehyde; D002097:C-Reactive Protein; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Chronic kidney disease; inflammation; oxidative stress