Capacitating epistasis--detection and role in the genetic architecture of complex traits.
Here, we discuss the potential role of capacitating epistasis in the genetic architecture of complex traits. Two alternative methods for identifying such gene-gene interactions in genetic association studies-mapping of variance controlling loci and the variance plane ratio (VPR) method-are introduced. An overview of the theoretical foundation of the methods is presented together with a discussion on their implementation and available software for performing these analyses. We conclude by highlighting a few examples of capacitating epistasis described in the literature and its potential impacts on the genetics of complex traits.
Division of Computational Genetics, Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7078, SE-750 07, Uppsala, Sweden.
Mats E
ME
Pettersson
Orjan
O
Carlborg
D005075:Biological Evolution; D004843:Epistasis, Genetic; D005821:Genetic Techniques; D005838:Genotype; D008957:Models, Genetic; D010641:Phenotype; D019655:Quantitative Trait, Heritable; D013223:Statistics as Topic