[Extracting and study of biochemical properties of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium].
The method of extraction and purification of thiamine pyrophosphokinase from non-malignant and tumor tissue of myometrium has been elaborated. Kinetic characteristics of T-kinase from non-malignant and tumor tissue of women myometrium have been studied. It has been shown, that malignization of myometrium is accompanied by a decrease in affinity of thiamine pyrophosphokinase from tumor to thiamine and by an increase in sensitivity of the enzyme from tumor to thiochrome.
O V
OV
Orishaka
I L
IL
Vovchuk
S A
SA
Petrov
D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000201:enzymology*; D009215:Myometrium / Q000201:enzymology*; D013836:Thiamin Pyrophosphokinase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013831:Thiamine / Q000031:analogs & derivatives / Q000494:pharmacology; D014594:Uterine Neoplasms / Q000201:enzymology*
C005793:thiochrome; D013836:Thiamin Pyrophosphokinase; D013831:Thiamine
inhibition; myometrium; thiamine; thiamine pyrophosphokinase; thiochrome