Recurrence of acute lymphocytic leukemia diagnosed by subretinal biopsy.
OBJECTIVE
To report a case of leukemia relapse in the subretinal space that was diagnosed by transvitreal subretinal biopsy.


METHODS
Case report and literature review.


RESULTS
A 5-year-old girl with prior history of acute lymphocytic leukemia who was in clinical remission was examined for a unilateral subretinal mass. Her systemic evaluation was negative for recurrence of the acute lymphocytic leukemia. Pars plana vitrectomy with a subretinal biopsy showed leukemic cells confirmed by flow cytometric immunophenotyping. The patient subsequently underwent bone marrow transplantation with regression of the subretinal mass.


CONCLUSIONS
Leukemia relapse may occur in the subretinal space. A relapse may be successfully diagnosed with a subretinal biopsy through a pars plana vitrectomy.
From the Department of Ophthalmology, Emory University, Atlanta, Georgia.
Alok S
AS
Bansal
G Baker
GB
Hubbard
Daniel F
DF
Martin
Hans
H
Grossniklaus