Secondary jaw aneurysmal bone cyst (JABC)--a possible misnomer? A review of literature on secondary JABCs, their pathogenesis and oncogenesis.
BACKGROUND
Aneurysmal bone cysts are rare pseudocysts, commonly seen in long bones and vertebral column. Although a well described and reported lesion, many misconceptions still prevail regarding their etiopathogenesis. Many of the reported cases of jaw aneurysmal bone cysts (JABC) present with another bone pathology.


OBJECTIVE
The purpose of this review was to evaluate the incidence of neoplastic lesions occurring simultaneously with a JABC (in contrast to primary JABCs). Any pathogenetic and oncogenetic association between primary and secondary jaw ABCs has been reviewed and discussed.


METHODS
A methodical narrative review of literature was performed, given the incidence of mostly case reports on this topic.


METHODS
A methodical electronic search of Pubmed, Pubmed Central, Medline and Cochrane databases was performed for reported cases of JABC. These articles were analysed and segregated into primary and secondary ABC and, if secondary, the lesion it concurrently occurred with. Another search was conducted to yield articles discussing the cytopathogenetic and oncogenetic origins of ABCs.


CONCLUSIONS
About 15% of the ABCs reported were of secondary nature. Amongst the associated lesions, cement-ossifying fibroma and ossifying fibroma were the most common, followed by fibrous dysplasia and central giant cell granuloma. No ABCs were associated with metastatic changes. The search for histopathogenesis pointed to a specific cytogenetic abnormality as the origin of primary ABCs, with USP6 as its main oncogene and spindle cell as the neoplastic cell, unlike with secondary ABCs, suggesting that they are distinct pathological processes.
Srimathy S
SS
Arora
Samrity
S
Paul
Sunil
S
Arora
Varun
V
Kapoor
D017824:Bone Cysts, Aneurysmal / Q000209:etiology*; D002485:Cementoma / Q000150:complications; D018214:Fibroma, Ossifying / Q000150:complications; D005357:Fibrous Dysplasia of Bone / Q000150:complications; D006101:Granuloma, Giant Cell / Q000150:complications; D006801:Humans; D007570:Jaw Cysts / Q000209:etiology*; D007571:Jaw Diseases / Q000150:complications; D007573:Jaw Neoplasms / Q000150:complications; D012008:Recurrence; D009626:Terminology as Topic