Delineating margins of lentigo maligna using a hyperspectral imaging system.
Lentigo maligna (LM) is an in situ form of melanoma which can progress into invasive lentigo maligna melanoma (LMM). Variations in the pigmentation and thus visibility of the tumour make assessment of lesion borders challenging. We tested hyperspectral imaging system (HIS) in in vivo preoperative delineation of LM and LMM margins. We compared lesion margins delineated by HIS with those estimated clinically, and confirmed histologically. A total of 14 LMs and 5 LMMs in 19 patients were included. HIS analysis matched the histo-pathological analysis in 18/19 (94.7%) cases while in 1/19 (5.3%) cases HIS showed lesion extension not confirmed by histopathology (false positives). Compared to clinical examination, HIS defined lesion borders more accurately in 10/19 (52.6%) of cases (wider, n = 7 or smaller, n = 3) while in 8/19 (42.1%) cases lesion borders were the same as delineated clinically as confirmed histologically. Thus, HIS is useful for the detection of subclinical LM/LMM borders.
Department of Dermatology and Allergology, Helsinki University Central Hospital, FIN-00029 Helsinki, Finland. noora.neittaanmaki@fimnet.fi.
Noora
N
Neittaanmäki-Perttu
Mari
M
Grönroos
Leila
L
Jeskanen
Ilkka
I
Pölönen
Annamari
A
Ranki
Olli
O
Saksela
Erna
E
Snellman
D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D046169:Dermoscopy / Q000379:methods*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging / Q000379:methods; D018450:Disease Progression; D005260:Female; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010781:Photography / Q000379:methods; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery