Constitutional and somatic deletions of the Williams-Beuren syndrome critical region in non-Hodgkin lymphoma.
Here, we report and investigate the genomic alterations of two novel cases of Non-Hodgkin Lymphoma (NHL) in children with Williams-Beuren syndrome (WBS), a multisystem disorder caused by 7q11.23 hemizygous deletion. Additionally, we report the case of a child with NHL and a somatic 7q11.23 deletion. Although the WBS critical region has not yet been identified as a susceptibility locus in NHL, it harbors a number of genes involved in DNA repair. The high proportion of pediatric NHL reported in WBS is intriguing. Therefore, the role of haploinsufficiency of genes located at 7q11.23 in lymphomagenesis deserves to be investigated.
Laboratory of Cellular and Molecular Biology, University Hospital of Besançon, 1 Bd Fleming, Batiment Diaclone, Besançon, France. david.guenat@univ-fcomte.fr.
David
D
Guenat
Samuel
S
Quentin
Carmelo
C
Rizzari
Catarina
C
Lundin
Tiziana
T
Coliva
Patrick
P
Edery
Helen
H
Fryssira
Laurent
L
Bermont
Christophe
C
Ferrand
Jean
J
Soulier
Christophe
C
Borg
Pierre-Simon
PS
Rohrlich
D002648:Child; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D055028:Comparative Genomic Hybridization; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000235:genetics*; D008297:Male; D018980:Williams Syndrome / Q000150:complications / Q000235:genetics*