Mesothelioma of the tunica vaginalis testis with prominent adenomatoid features: a case report.
Malignant mesotheliomas of the testis arise from the tunica vaginalis, formed from the evagination of the abdominal peritoneum into the scrotum. It is an extremely rare tumor representing 0.3% to 5% of all malignant mesotheliomas. We presented an interesting case of 68-year-old male with swelling and slightly painful in the right scrotum. Histologically, the lesion were composed of small tubular, microcystic, gland lined by flattened epithelioid cells and vague signet ring cells set in a myxofibrous stroma, which is resemblance to adenomatoid tumor. But the tumor cells showed significant atypical cytologic morphology and invaded into spermatic cord tissue, which indicated the diagnosis of malignant tumor. Immunohistochemistry study showed positive expression of CK, CK5/6, CK7, Calretinin, D2-40 and Vimentin which indicated the diagnosis of malignant mesothelioma. This case of mesothelioma should be classified as epithelial in type. To our knowledge, the mesothelioma of the tunica vaginalis testis with adenomatoid tumor-like microscopic features is very rare.
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Lian-He
LH
Yang
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Juan-Han
JH
Yu
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Hong-Tao
HT
Xu
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Xu-Yong
XY
Lin
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Yang
Y
Liu
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Yuan
Y
Miao
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Liang
L
Wang
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Chui-Feng
CF
Fan
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
Gui-Yang
GY
Jiang
Department of Radiotherapy, The First Affiliated Hospital and College of Basic, Medical Sciences, China Medical University Shenyang 110001, China.
Si-Lu
SL
Ding
Department of Radiotherapy, The First Affiliated Hospital and College of Basic, Medical Sciences, China Medical University Shenyang 110001, China.
Guang
G
Li
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University Shenyang 110001, China ; Institute of Pathology and Pathophysiology, China Medical University Shenyang 110001, China.
En-Hua
EH
Wang
D018254:Adenomatoid Tumor / Q000737:chemistry / Q000473:pathology*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008654:Mesothelioma / Q000737:chemistry / Q000473:pathology*; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D013736:Testicular Neoplasms / Q000737:chemistry / Q000473:pathology*
D014408:Biomarkers, Tumor
Mesothelioma; adenomatoid; histology; tunica vaginalis testis