Ocular prostate cancer metastasis treated with external beam radiation.
OBJECTIVE
The purpose of this study was to report a rare case of ocular metastasis from prostate cancer treated successfully with external beam radiation therapy.


METHODS
Case report and literature review.


METHODS
A 60-year-old man with a history of metastatic castration-resistant prostate cancer presented with decreased visual acuity in the right eye. Ophthalmoscopic examination showed a choroidal mass with characteristic surface retinal pigment epithelium spots (leopard spots), consistent with a metastatic tumor. The patient was treated with external beam radiation therapy. He had a dramatic improvement in visual acuity within 4 weeks of completing radiation treatment. Two and half years from radiation treatment to the right eye, he has maintained excellent vision (20/20 with best correction) in spite of systemic disease progression.


CONCLUSIONS
Uveal metastasis is a rare cause of unexplained blurred vision in the setting of metastatic adenocarcinoma of prostate. Palliative external beam radiotherapy provides effective and durable relief of symptoms during treatment and is generally a well-tolerated regimen with low risk of long-term morbidity.
From the *Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington; †Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington; and ‡Division of Oncology, Department of Medicine, University of Washington School of Medicine, Seattle Cancer Care Alliance, Seattle, Washington.
Ralph P
RP
Ermoian
Robert E
RE
Kalina
Evan Y
EY
Yu
Upendra
U
Parvathaneni