Clinical care of two patients with Ebola virus disease in the United States.
West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.
From the Departments of Medicine (G.M.L., A.K. Mehta, J.B.V., C.S.K., B.S.R.), Pathology (C.S.K.), and Pediatrics (A.K. McElroy), Division of Infectious Diseases, Emory University School of Medicine, and the Centers for Disease Control and Prevention (A.K. McElroy, J.S.T., C.S., U.S., T.M.U.) - both in Atlanta; and Samaritan's Purse, Boone, NC (K.B., L.P.).
G Marshall
GM
Lyon
Aneesh K
AK
Mehta
Jay B
JB
Varkey
Kent
K
Brantly
Lance
L
Plyler
Anita K
AK
McElroy
Colleen S
CS
Kraft
Jonathan S
JS
Towner
Christina
C
Spiropoulou
Ute
U
Ströher
Timothy M
TM
Uyeki
Bruce S
BS
Ribner
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000627:therapeutic use*; D004196:Disease Outbreaks; D015507:Drugs, Investigational / Q000627:therapeutic use*; D029043:Ebolavirus / Q000276:immunology*; D005260:Female; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D006801:Humans; D007988:Liberia; D008297:Male; D008875:Middle Aged; D014481:United States
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D015507:Drugs, Investigational; C000594176:ZMapp