Three-dimensional structure of foot-and-mouth disease virus and its biological functions.
Foot-and-mouth disease (FMD), an acute, violent, infectious disease of cloven-hoofed animals, remains widespread in most parts of the world. It can lead to a major plague of livestock and an economical catastrophe. Structural studies of FMD virus (FMDV) have greatly contributed to our understanding of the virus life cycle and provided new horizons for the control and eradication of FMDV. To examine host-FMDV interactions and viral pathogenesis from a structural perspective, the structures of viral structural and non-structural proteins are reviewed in the context of their relevance for virus assembly and dissociation, formation of capsid-like particles and virus-receptor complexes, and viral penetration and uncoating. Moreover, possibilities for devising novel antiviral treatments are discussed.
State Key Laboratory of Veterinary Etiological Biology and OIE/National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, 730046, Gansu, People's Republic of China.
Shi-Chong
SC
Han
Hui-Chen
HC
Guo
Shi-Qi
SQ
Sun
D000818:Animals; D029544:Foot-and-Mouth Disease Virus / Q000502:physiology* / Q000648:ultrastructure*; D008958:Models, Molecular; D011487:Protein Conformation; D015678:Viral Structural Proteins / Q000737:chemistry* / Q000378:metabolism*; D019065:Virus Assembly
D015678:Viral Structural Proteins