Circulating microRNA-19a as a potential novel biomarker for diagnosis of acute myocardial infarction.
Acute myocardial infarction (AMI) is a serious cardiovascular disease. Investigating new susceptibility genes for effective methods of early diagnosis of AMI is important. In the current study, peripheral blood miR-19a levels were detected by real-time polymerase chain reaction. Significant differences and logistic correlation analyses were carried out by grouping of disease types and stratification of risk factors. Receiver-operator characteristic curve analysis was used to compare the current common clinical biochemical markers and evaluate the sensitivity and specificity of miR-19a for diagnosing AMI. Circulating miR-19a expression in the AMI group was higher than that in controls. The diagnostic effect of circulating miR-19a levels was superior to current clinical biochemical indices, such as CK, CK-MB, MYO, hs-TnI, and BNP. Our results show that there is a close association of circulating miR-19a levels with susceptibility to AMI. Circulating miR-19a levels could be a candidate diagnostic biomarker for AMI.
Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China. 15900130806@126.com.
Jianfeng
J
Zhong
Laboratory of Cardiovascular Diseases, Guangdong Medical College, Zhanjiang 524001, China. yvette.he@hotmail.com.
Yuan
Y
He
Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China. yezi62002413@163.com.
Wenjiang
W
Chen
Laboratory of Vascular Surgery, Guangdong Medical College, Zhanjiang 524001, China. shuixiaor@gmail.com.
Xiaorong
X
Shui
Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China. chencan-21@163.com.
Can
C
Chen
Department of Cardiovascular Medicine, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524000, China. thdmast@gmail.com.
Wei
W
Lei
D016632:Apolipoprotein A-I / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis*; D012372:ROC Curve; D012307:Risk Factors
D016632:Apolipoprotein A-I; D015415:Biomarkers; C544547:MIRN1 microRNA, human; C549214:MIRN19A microRNA, human; D035683:MicroRNAs