Study of Auditory, Visual Reaction Time and Glycemic Control (HBA1C) in Chronic Type II Diabetes Mellitus.
BACKGROUND
Diabetes mellitus is a disease of insulin deficiencyleads to micro and macro vascular disorder. Neuropathy is one of the major complication of chronic uncontrolled Diabetes affecting the Reaction time.


OBJECTIVE
To study the correlation between the glycosylated HbA1C and Auditory, visual Reaction time in chronic Type II diabetes (40-60y) of on oral hypoglycemic drugs of>10 y duration in two groups (n-100 in each group , both Males & females) and compared within the study groups and also with the age matched control group (100).


METHODS
HbA1C-Glycosylated HbA1C was measured by Particle enhanced immunoturbidimetric test method. Auditory and visual reaction time (ART, VRT) were measured by PC 1000 Reaction timer for control & study groups i.e. Group-I - Chronic Type II DM for >10 y with HbA1c < 7.0, and Group II - chronic Type-IIDM for >10 y with HbA1c > 7.0 ie impaired glycemic control. Exclusion Criteria- Subjects with Auditory and visual disturbances, alcoholism and smoking. Statistical Analysis - One-way ANOVA. Using SPSS 21 software.


RESULTS
Both the groups had prolonged ART and VRT than controls. Among the study group, G-II (DM with HbA1C >7) had increased Auditory & Visual Reaction time than Group I which is statistically significant p-value <0.05.


CONCLUSIONS
Impairment of sensory motor function of peripheral nervous system is more in chronic diabetic with less glycemic control ie., HbA1C>7 who have shown increased Auditory and Visual Reaction time than chronic DM with HbA1C<7.Severity of Peripheral neuropathy in Type II Diabetics could be due to elevated HbA1C.
Associate Professor, Department of Physiology, Chennai Medical College Hospital & Research Centre , Trichy, Tamilnadu, India .
Muhil
M
M
Associate Professor, Department of Anatomy, Chennai Medical College Hospital & Research Centre , Trichy, Tamilnadu, India .
Umapathy
U
Sembian
Assistant Professor, Department of Physiology, Vinayaka Missions University , Salem, Pondicherry, India .
Babitha
Reader, Department of Physiology, Madurai Medical College , Madurai, India .
Ethiya
E
N
Reader, Department of Physiology, Madurai Medical College , Madurai, India .
Muthuselvi
M
K
Auditory reaction time; Type-II diabetes mellitus; Visual reaction time