Dietary rapeseed/canola-oil supplementation reduces serum lipids and liver enzymes and alters postprandial inflammatory responses in adipose tissue compared to olive-oil supplementation in obese men.
METHODS
Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state.


RESULTS
This study investigates the effects of a daily supplementation of either 50 g of rapeseed/canola (RA) or olive (OL) oil over 4 wk on serum lipids, serum liver enzymes, and inflammatory gene expression in subcutaneous (s. c.) adipose tissue in obese men. Consuming RA resulted in increased serum n-3 fatty acids and a reduction in total cholesterol, LDL cholesterol, and serum aspartate aminotransferase compared to OL. In s. c. adipose tissue, gene expression of the pro-inflammatory cytokine IL6 was reduced in RA compared to OL. However, after 4 h after a test meal, containing the appropriate oil, white bread, and 400 mL of liquid diet drink (835 kcal in total), gene expression of IL6, IL1B, and EMR1 (egf-like module containing Mucin-like hormone receptor-like 1) was increased in RA and of monocyte chemoattractant protein-1 (CCL2) in both RA and OL.


CONCLUSIONS
This demonstrates that consuming RA for 4 wk improves serum lipids, liver enzymes, and basal inflammation in s. c. adipose tissue, but it mediates an acute pro-inflammatory response in adipose tissue upon consuming a meal.
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Department of Endocrinology, Diabetes and Nutrition, Charité University Medicine Berlin, Berlin, Germany.
Michael
M
Kruse
Christian
C
von Loeffelholz
Daniela
D
Hoffmann
Antje
A
Pohlmann
Anne-Cathrin
AC
Seltmann
Martin
M
Osterhoff
Silke
S
Hornemann
Olga
O
Pivovarova
Sascha
S
Rohn
Gerhard
G
Jahreis
Andreas F H
AF
Pfeiffer
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition / Q000187:drug effects; D018932:Chemokine CCL2 / Q000097:blood; D019587:Dietary Supplements; D005229:Fatty Acids, Monounsaturated / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000378:metabolism; D015434:Panniculitis / Q000188:drug therapy / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D019518:Postprandial Period; D000074262:Rapeseed Oil
D001786:Blood Glucose; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005229:Fatty Acids, Monounsaturated; C508600:IL6 protein, human; D007328:Insulin; D015850:Interleukin-6; D008055:Lipids; D010938:Plant Oils; D000074262:Rapeseed Oil
Inflammation; Obesity; Olive oil; Rapeseed oil; Serum lipids