Karwinaphthopyranones from the fruits of Karwinskia parvifolia and their cytotoxic activities.
The new 2-acetyl-8-methoxynaphthol (1) and five new "dimeric" napthopyranones, karwinaphthopyranones A1 and A2 (2 and 3) and karwinaphthopyranones B1-B3 (4-6), possessing a methoxy group at C-5', were isolated together with four other known compounds from the dried fruits of Karwinskia parvifolia. The structures of compounds 2-6 were determined by spectroscopic data interpretation. Cell culture assays showed that some of these compounds possess antiproliferative activities in representative human cancer cell lines, with half-maximal growth inhibitory concentrations in the micromolar range.
Medicinal and Natural Products Chemistry, The University of Iowa , Iowa City, Iowa 52242, United States.
Claudia
C
Rojas-Flores
María Yolanda
MY
Rios
Rebeca
R
López-Marure
Horacio F
HF
Olivo
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D031956:Karwinskia / Q000737:chemistry*; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C000599230:2-acetyl-8-methoxynaphthol; D000972:Antineoplastic Agents, Phytogenic; D009284:Naphthols; D011753:Pyrones; C000599231:karwinaphthopyranone A1