Research progress on the livin gene and osteosarcomas.
Osteosarcoma is a common malignant tumor of bone, but mechanisms underlying its development are still unclear. At present, it is believed that the inhibition of normal apoptotic mechanisms is one of the reasons for the development of tumors, so specific stimulation of tumor cell apoptosis can be considered as an important therapeutic method. Livin, as a member of the newly discovered inhibitor of apoptosis proteins (IAPs) family, has specifically high expression in tumor tissues and can inhibit tumor cell apoptosis through multiple ways, which can become a new target for malignant tumor treatment (including osteosarcoma) and might of great significance in the clinical diagnosis of tumors and the screening of anti-tumor agents and carcinoma treatment.
Jinling Hosp, Dept Orthopedics, Nanjing Univ, Sch Med, Nanjing 210002, China E-mail : shixin2k@163.com.
Cheng-Jun
CJ
Li
Yu
Y
Cong
Xiao-Zhou
XZ
Liu
Xing
X
Zhou
Xin
X
Shi
Su-Jia
SJ
Wu
Guang-Xin
GX
Zhou
Meng
M
Lu
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D017209:Apoptosis / Q000235:genetics; D035843:Biomedical Research; D001859:Bone Neoplasms / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics*; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D012516:Osteosarcoma / Q000235:genetics* / Q000503:physiopathology
D048868:Adaptor Proteins, Signal Transducing; C419866:BIRC7 protein, human; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins