Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis.
Charcot-Marie-Tooth Neuropathy Score second version (CMTNSv2) is a validated clinical outcome measure developed for use in clinical trials to monitor disease impairment and progression in affected CMT patients. Currently, all items of CMTNSv2 have identical contribution to the total score. We used Rasch analysis to further explore psychometric properties of CMTNSv2, and in particular, category response functioning, and their weight on the overall disease progression. Weighted category responses represent a more accurate estimate of actual values measuring disease severity and therefore could potentially be used in improving the current version.
Department of Neurology, University of Virginia, Charlottesville, VA, USA.
Reza
R
Sadjadi
Mary M
MM
Reilly
Michael E
ME
Shy
Davide
D
Pareyson
Matilde
M
Laura
Sinead
S
Murphy
Shawna M E
SM
Feely
Tiffany
T
Grider
Chelsea
C
Bacon
Giuseppe
G
Piscosquito
Daniela
D
Calabrese
Ted M
TM
Burns
D002607:Charcot-Marie-Tooth Disease / Q000175:diagnosis*; D018450:Disease Progression; D006801:Humans; D011594:Psychometrics / Q000295:instrumentation*; D012720:Severity of Illness Index
Charcot-Marie-Tooth; Charcot-Marie-Tooth Neuropathy Score (CMTNS2) second version; Rasch analysis; outcome measures; psychometrics