MicroRNAs meet calcium: joint venture in ER proteostasis.
The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca(2+) concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca(2+) handling and storage and maintain ER homeostasis.
Institute for Genetics and Cologne Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.
Fabian
F
Finger
Institute for Genetics and Cologne Cluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany. thorsten.hoppe@uni-koeln.de.
Thorsten
T
Hoppe
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004195:Disease Models, Animal; D004220:Disulfides; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D007477:Ions; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D017510:Protein Folding; D056811:Unfolded Protein Response
D004220:Disulfides; D007477:Ions; D035683:MicroRNAs; D002118:Calcium