Effects of lactic acid bacteria on low-density lipoprotein susceptibility to oxidation and aortic fatty lesion formation in hyperlipidemic hamsters.
We investigated the effects of Streptococcus thermophilus YIT 2001, a strain of lactic acid bacteria, on the susceptibility of low-density lipoprotein (LDL) to oxidation and the formation of aortic fatty lesions in hyperlipidemic hamsters. S. thermophilus YIT 2001 had the highest in vitro antioxidative activity against LDL oxidation among the 79 strains of lactic acid bacteria and bifidobacteria tested, which was about twice that of S. thermophilus YIT 2084. The lag time of LDL oxidation in the YIT 2001 feeding group was significantly longer than in controls, but was unchanged in the YIT 2084 group. After the feeding of YIT 2001, lag times were prolonged and areas of aortic fatty lesions were dose-dependently attenuated, although there were no effects on plasma lipid levels. These results suggest that YIT 2001 has the potential to prevent the formation of aortic fatty lesions by inhibiting LDL oxidation.
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
M
M
Ito
Yakult Honsha European Research Center for Microbiology ESV, Technologiepark 4, 9052 Gent-Zwijnaarde, Belgium.
K
K
Oishi
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
Y
Y
Yoshida
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
T
T
Okumura
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
T
T
Sato
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
E
E
Naito
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
W
W
Yokoi
Yakult Central Institute, Yaho 1796, Kunitachi-shi, Tokyo, 186-8650 Japan.
H
H
Sawada
D000818:Animals; D001011:Aorta / Q000378:metabolism* / Q000473:pathology; D006224:Cricetinae; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008647:Mesocricetus; D010084:Oxidation-Reduction; D019936:Probiotics / Q000008:administration & dosage*; D048249:Streptococcus thermophilus / Q000502:physiology*
D008055:Lipids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein
LDL; antioxidative activity; atherosclerosis