Intravascular ATP and the regulation of blood flow and oxygen delivery in humans.
Regulation of vascular tone is a complex response that integrates multiple signals that allow for blood flow and oxygen supply to match oxygen demand appropriately. Here, we discuss the potential role of intravascular adenosine triphosphate (ATP) as a primary factor in these responses and put forth the hypothesis that deficient ATP release contributes to impairments in vascular control exhibited in aged and diseased populations.
1Department Health and Sport Science, University of Dayton, Dayton, OH; 2Digital Sport Science Laboratory, Nike Inc., Beaverton, OR; and 3Departments of Health and Exercise Science, and 4Biomedical Sciences, Colorado State University, Fort Collins, CO.
Anne R
AR
Crecelius
Brett S
BS
Kirby
Frank A
FA
Dinenno
D000255:Adenosine Triphosphate / Q000097:blood*; D000818:Animals; D015444:Exercise / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D010101:Oxygen Consumption / Q000502:physiology*; D013314:Stress, Mechanical; D013564:Sympathetic Nervous System / Q000502:physiology; D014661:Vasoconstriction; D014664:Vasodilation
D000255:Adenosine Triphosphate