[New possibilities of pharmacotherapy in cardiovascular patients with mental disorders].
OBJECTIVE
To study the efficacy and tolerability of the drugs pantogam active and phenotropil in mild neurotic, somatoform, stress-induced and depressive disorders developed in patients with cardiovascular diseases.


METHODS
The effect of pantogam active was assessed in an open study. The main group of patients (n=35) treated with phenotropil during 12 weeks was compared to the comparison group (n=35). Patient's status was evaluated using psychometric (CGI, HDRS etc) and adverse effect scales. RESULTS AND СONCLUSION: Statistically significant results demonstrated the advantages of pantogam active has advantage on a number of values. The treatment effect of pantogam active gradually increased while the effect (in particular anxiolytic one) of phenotropil decreased after 4-8 weeks of treatment. The tolerability of both drugs was satisfactory.
V E
VE
Medvedev
V I
VI
Frolova
A V
AV
Epifanov
D002318:Cardiovascular Diseases / Q000150:complications*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018697:Nootropic Agents / Q000008:administration & dosage*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013315:Stress, Psychological / Q000150:complications*; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*
D018697:Nootropic Agents; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; C037917:4-phenylpiracetam; D010889:Piracetam