Neoadjuvant concurrent chemoradiation for curative treatment of penile squamous cell carcinoma.
Introduction. Penile cancer is a rare malignancy often treated with neoadjuvant chemotherapy followed by surgery. However, the utility of neoadjuvant chemoradiation, particularly when the tumor is resistant to chemotherapy alone, has not been established. In this study, we report a case of pT3cN3M0 penile squamous cell carcinoma with progression of nodal disease on chemotherapy, which was cured with use of neoadjuvant concurrent chemoradiation. Case Report. A 65-year-old male presented with a fixed left inguinal lymph node with associated firmness of the penile glans. Biopsies of both sites revealed evidence of squamous cell carcinoma. The patient underwent partial penectomy for the primary lesion and began neoadjuvant chemotherapy to reduce the size of the unresectable left inguinal node. However, he displayed disease progression in the left inguinal node. As such, we attempted concurrent chemoradiation therapy with regression of his nodal disease. The patient was able to undergo left inguinal node dissection and has no evidence of disease 18 months since his initial surgery. Conclusion. The use of neoadjuvant chemoradiation for bulky cN2-3 disease seems appropriate in the setting of progressive disease. Further studies are necessary to assess the utility of concurrent chemoradiation both in the neoadjuvant and salvage setting.
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA ; Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA.
Arpit
0000-0002-0604-0914
A
Chhabra
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA ; Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA.
David
D
Schwartz
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA.
Andrea
A
Leaf
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA.
Nikolaos
N
Karanikolas
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA ; Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA.
Jeffrey P
JP
Weiss
Department of Veterans Affairs, New York Harbor Healthcare System, 800 Poly Place, Suite 114A, Brooklyn, NY 11209, USA ; Downstate Medical Center, State University of New York, Brooklyn, NY 11203, USA.
David
D
Schreiber