MR imaging probes: design and applications.
This perspective outlines strategies towards the development of MR imaging probes that our lab has explored over the last 15 years. Namely, we discuss methods to enhance the signal generating capacity of MR probes and how to achieve tissue specificity through protein targeting or probe activation within the tissue microenvironment.
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Eszter
E
Boros
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Eric M
EM
Gale
Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Peter
P
Caravan
D000818:Animals; D015195:Drug Design; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011506:Proteins / Q000378:metabolism; D012399:Rotation; D014867:Water / Q000737:chemistry
D011506:Proteins; D014867:Water