Oxidative nanopeeling chemistry-based synthesis and photodynamic and photothermal therapeutic applications of plasmonic core-petal nanostructures.
The precise control of plasmonic nanostructures and their use for less invasive apoptotic pathway-based therapeutics are important but challenging. Here, we introduce a highly controlled synthetic strategy for plasmonic core-petal nanoparticles (CPNs) with massively branched and plasmonically coupled nanostructures. The formation of CPNs was facilitated by the gold chloride-induced oxidative disassembly and rupture of the polydopamine corona around Au nanoparticles and subsequent growth of Au nanopetals. We show that CPNs can act as multifunctional nanoprobes that induce dual photodynamic and photothermal therapeutic effects without a need for organic photosensitizers, coupled with the generation of reactive oxygen species (ROS), and allow for imaging and analyzing cells. Near-infrared laser-activated CPNs can optically monitor and efficiently kill cancer cells via apoptotic pathway by dual phototherapeutic effects and ROS-mediated oxidative intracellular damage with a relatively mild increase in temperature, low laser power, and short laser exposure time.
Department of Chemistry, Seoul National University , Seoul 151-747, South Korea.
Amit
A
Kumar
Sumit
S
Kumar
Won-Kyu
WK
Rhim
Gyeong-Hwan
GH
Kim
Jwa-Min
JM
Nam
D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006046:Gold / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D017612:Gold Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry; D053768:Metal Nanoparticles; D050997:Nanomedicine / Q000379:methods*; D010084:Oxidation-Reduction; D010778:Photochemotherapy; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties
D017612:Gold Compounds; D007211:Indoles; D011108:Polymers; C568283:polydopamine; C038016:gold chloride; D006046:Gold