Polymyxin B infusion leading to cardiac arrest: a case report and literature review.
We describe a 52-year-old female patient who developed cardiopulmonary arrest due to neuromuscular paralysis after initiation of polymyxin B for septicemia caused by extended spectrum β-lactamase-producing Klebsiella pneumoniae. Due to emerging antibiotic resistance patterns, use of polymyxins is increasing and an understanding of their toxicity is critical.
Department of Internal Medicine, Meharry Medical College, 1005 Dr. DB Todd Jr BLVD, Nashville, TN, 37208, USA, mberie@mmc.edu.
M B
MB
Berie
M S
MS
King
I P
IP
Thomsen
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D017809:Fatal Outcome; D005260:Female; D006323:Heart Arrest / Q000139:chemically induced*; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy; D007711:Klebsiella pneumoniae; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011112:Polymyxin B / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D011112:Polymyxin B