Serum paraoxonase 1 (PON1) activity in acute pancreatitis of dogs.
OBJECTIVE
Serum paraoxonase 1 is considered a marker of inflammation and oxidative damage. The aims of this study were to evaluate changes in serum paraoxonase 1 activity in dogs with acute pancreatitis, to correlate serum paraoxonase 1 activity and other analytes known to be altered in dogs with pancreatitis and to assess the relationship between serum paraoxonase 1 activity and disease severity in dogs with acute pancreatitis.


METHODS
Retrospective analysis of dogs with acute pancreatitis and healthy dogs in which serum paraoxonase 1 activity was measured were compared.


RESULTS
Median serum paraoxonase 1 activity was significantly lower in dogs with pancreatitis (n = 19) compared to healthy ones (n = 19). Serum paraoxonase 1 activity was negatively correlated with serum lipase and amylase activities, and C-reactive protein and haptoglobin concentrations and was positively correlated with total cholesterol and glucose concentration. Disease severity was negatively correlated with serum paraoxonase 1 activity and positively correlated with triglyceride and C-reactive protein concentration.


CONCLUSIONS
Serum paraoxonase 1 activity is lower in dogs with acute pancreatitis and together with triglyceride and C-reactive protein concentrations is a potential marker of disease severity.
Departament de Medicina i Cirurgia Animals, Universitat Autònoma de Barcelona, 08193, Bellaterra, Barcelona, Spain.
A
A
Tvarijonaviciute
J D
JD
García-Martínez
M
M
Caldin
S
S
Martínez-Subiela
F
F
Tecles
J
J
Pastor
J J
JJ
Ceron
D000208:Acute Disease; D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004283:Dog Diseases / Q000097:blood / Q000175:diagnosis / Q000201:enzymology*; D004285:Dogs; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis / Q000201:enzymology / Q000662:veterinary*; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D014280:Triglycerides; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase