Vitamin D status and thyroid autoimmunity in Korean pregnant women.
OBJECTIVE
There is increasing interest in the role of vitamin D (vitD) during pregnancy. We prospectively evaluated the vitD status in Korean pregnant women and evaluated the levels of vitD according to thyroid-specific autoimmunity during pregnancy.


METHODS
We included pregnant 531 women who visited for prenatal care and 238 age-matched, non-pregnant women as a control population. The levels of thyrotropin, FT4, thyroid peroxidase (TPO), thyroglobulin (Tg) antibody (Ab) and 25-hydroxy vitamin D [25(OH)D] were measured by electrochemiluminescence immunoassays.


RESULTS
The mean levels of 25(OH)D at trimester 1, 2 and 3 were 13.6, 15.6 and 19.3 ng/mL, respectively; and the prevalence of vitD insufficiency was 83.6%, 75.1% and 55.9%, respectively. The mean 25(OH)D levels were not significantly different between Tg and TPO Ab-positive and negative pregnant women (14.9 versus 16.1, and 14.9 versus 16.1 ng/mL, respectively).


CONCLUSIONS
vitD insufficiency was exceptionally high, especially in the first trimester, in Korean pregnant women. The mean 25(OH)D levels were not significantly different according to autoimmunity. Further studies on this relationship could provide important information to assess the vitD status in patients with thyroid autoimmunity during pregnancy.
a Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea and.
Hee-Won
HW
Moon
b Department of Laboratory Medicine , Cheil General Hospital and Women's Healthcare Center, Kwandong University College of Medicine , Seoul , Republic of Korea.
Hee-Jung
HJ
Chung
a Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea and.
Mina
M
Hur
a Department of Laboratory Medicine , Konkuk University School of Medicine , Seoul , Republic of Korea and.
Yeo-Min
YM
Yun
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D056910:Republic of Korea / Q000453:epidemiology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*
D015415:Biomarkers
Autoimmunity; pregnancy; thyroid; vitamin D