[Comparison of basic carboxypeptidases activity in male rats tissues at a single injection of haloperidol].
The influence of a single injection of haloperidol on basic carboxypeptidases (biologically active peptide processing enzymes) activity in rat tissues was studied. Acute exposure to haloperidol increased the activity of carboxypeptidases H (CP H) in hypothalamic-pituitary-adrenal system and cerebellum and reduced such activity in testes. Multidirectional changes of PMSF-inhibited carboxypeptidases activity (PMSF-CP) were observed after a single haloperidol injection in all studied tissues except testes. It is suggested that changes of CP H and PMSF-CP activity might affect levels of regulatory peptides in the brain and blood and thus may be involved in general and side effects of haloperidol on the organism.
N A
NA
Pravosudova
I O
IO
Bykova
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000201:enzymology; D007274:Injections, Intraperitoneal; D008297:Male; D009928:Organ Specificity; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000201:enzymology; D011480:Protease Inhibitors / Q000494:pharmacology; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D014105:Tosyl Compounds / Q000494:pharmacology
D011480:Protease Inhibitors; D014105:Tosyl Compounds; C003614:4-toluenesulfonyl fluoride; D002268:Carboxypeptidases; D006220:Haloperidol
PMSF-inhibited carboxypeptidase; carboxypeptidase H; haloperidol; neuropeptides