Rhodium(II)-catalyzed intramolecular formal [4 + 3] cycloadditions of dienyltriazoles: rapid access to fused 2,5-dihydroazepines.
Rhodium(II)-catalyzed intramolecular [4 + 3] cycloadditions of dienyltriazoles have been developed, which enable the efficient synthesis of various fused 2,5-dihydroazepines. Mechanistically, the titled reaction proceeds via an interesting tandem cyclopropanation/aza-cope rearrangement.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100193, P. R. China.
Yu
Y
Tian
Yuanhao
Y
Wang
Hai
H
Shang
Xudong
X
Xu
Yefeng
Y
Tang
D001381:Azepines / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D061565:Cycloaddition Reaction; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012238:Rhodium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D001381:Azepines; D014230:Triazoles; D012238:Rhodium