Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury.
BACKGROUND
Hyperglycemia exacerbates brain damage caused by cerebral ischemia. Neuroinflammation may play a role in mediating such enhanced damage. The objectives of this study were to examine the mRNA and protein levels and cell type distribution of ICAM-1 after cerebral ischemia in normo-and diabetic hyperglycemic rats.


RESULTS
Compared to normoglycemic ischemia animals, diabetes aggravated neuronal death, decreased Nissl body staining, and increased ICAM-1 mRNA and protein levels in the frontal cortex. The increased ICAM-1 was located not only in vascular endothelial cells but also in cortical neurons.


CONCLUSIONS
Our results suggest that exacerbated neuro-inflammation in the brain may mediate the detrimental effects of diabetes on the ischemic brain.
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Li
L
Jing
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Jian-Gang
JG
Wang
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Jian-Zhong
JZ
Zhang
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Cai-Xia
CX
Cao
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Yue
Y
Chang
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Jian-Da
JD
Dong
Department of Pathology, Ningxia Medical University and Ningxia Key Laboratory for Cerebrocranial Diseases, Incubation Base of National Key Laboratory, Yinchuan, Ningxia P. R. China.
Feng-Ying
FY
Guo
Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technological Enterprise (BRITE), North Carolina Central University, Durham, North Carolina USA.
P Andy
PA
Li
Cerebral ischemia; Endothelia; Forebrain ischemia; ICAM-1; Inflammation; Neurodegeneration; Neuron; Stroke