Role of CXCL12 and CXCR4 in normal cerebellar development and medulloblastoma.
Chemokines and its receptors have significant impact on physiological and pathological processes and studies concerning their association with tumor biology are subject of great interest in scientific community. CXCL12/CXCR4 axis has been widely studied due to its significant role in tumor microenvironment, but it is also important to development and maintenance of tissues and organs, for example, in the brain and cerebellum. Studies have demonstrated that CXCL12 and CXCR4 are required for normal cerebellar development and that dysfunction in this pathway may be involved with medulloblastoma pathogenesis. In this context, a new molecular subgroup has been suggested based on the importance of the association between CXCR4 overexpression and sonic hedgehog subgroup. Treatment using CXCR4 antagonists showed significant results, evidencing the important role and possible therapeutic capacity of CXCR4 in MB. This review summarizes studies on MB cell biology, focusing on a chemokine-receptor axis, CXCL12/CXCR4, that may have implications for treatment strategies once it can improve life expectancy and reduce neurocognitive sequelae of patients with this neoplasia.
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Patricia Midori Murobushi
PM
Ozawa
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Carolina Batista
CB
Ariza
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Cintya Mayumi
CM
Ishibashi
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Thiago Cezar
TC
Fujita
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Bruna Karina
BK
Banin-Hirata
Federal University of Mato Grosso do Sul, Três Lagoas, Brazil.
Julie Massayo Maeda
JM
Oda
Department of Pathological Sciences, Laboratory of Study and Application of DNA Polymorphisms, Biological Sciences Center, State University of Londrina, Brazil.
Maria Angelica Ehara
MA
Watanabe
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000378:metabolism*; D002531:Cerebellum / Q000196:embryology* / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000378:metabolism*; D038081:Organogenesis; D019718:Receptors, CXCR4 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
D054377:Chemokine CXCL12; D019718:Receptors, CXCR4
CXCL12; CXCR4; cerebellum; chemokines; childhood cancer