Dynamic changes of the various cytokines following carotid artery stenting.
OBJECTIVE
To observe the serum inflammatory and coagulation factors changes and clinical significance following carotid artery stenting.


METHODS
The expressions of serum inflammatory factors including IL-2, IL-6, IL-8, sICAM-1, hs-CRP, and TNF-α and serum coagulation factors including prothrombin time (PT), active partial thromboplastin time (APTT), fibrinogen (FIB), D-dimer (DD), and fibrin degradation products (FDP) were determined in 92 patients who had undergone carotid artery stenting before, 24h, 48 h, 3 days and 1 week after the surgery. As well, 92 subjects who did not receive stenting were enrolled in the angiography group, amongst whom the same variables were determined.


RESULTS
In the stenting group, the expressions of hs-CRP, TNF-α, sICAM-1, IL-6, IL-8, FIB, and DD were significantly increased after the surgery (p < 0.05): hs-CRP reached a peak 48 h after the surgery; TNF-α, sICAM-1, and IL-6 maintained at high levels at days 3-7; and FIB and DD increased 48 h and 3d after the surgery. Compared with the angiography group, the expressions of hs-CRP, TNF-α, sICAM-1, and IL-8 (24h after the surgery) as well as FIB and DD (48 h and 3d after the surgery) were significantly higher in the stenting group.


CONCLUSIONS
The hs-CRP, TNF-α, sICAM-1, IL-8, FIB, and DD increased after carotid artery stenting and, therefore, can serve as important factors for monitoring for acute postoperative complications.
Department of Neurology, No. 264 Hospital, Taiyuan, Shanxi Province, China. jiating814@sina.com.
X-J
XJ
Jia
S-Z
SZ
Fang
Q-F
QF
Zhu
R-T
RT
Xie
Z-Y
ZY
Liu
D000368:Aged; D002339:Carotid Arteries / Q000601:surgery*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000209:etiology; D015607:Stents
D016207:Cytokines; D015850:Interleukin-6