Hypofractionated radiation therapy for the treatment of microscopic canine soft tissue sarcoma.
Soft tissue sarcomas (STSs) are locally invasive and surgery with or without radiation therapy is the current standard of care in dogs. Typical protocols for treating incompletely excised STSs involve curative intent radiation with total dose in excess of 50 Gy. Forty-eight dogs with histologically confirmed incomplete or closely excised STSs were treated with a hypofractionated protocol that is typically reserved for palliative radiation therapy (RT) (6-8 Gy/weekly fractions to a total dose of 24-32 Gy). Ten dogs (21%) developed local recurrence, 11 dogs (23%) developed metastasis, and 3 dogs developed both (included in each group). The median progression free survival was 698 days. The local failure-free probability at 1 and 3 years was 81 and 73%. The 1 and 3 years tumour-specific overall survival was 81 and 61%. Long-term local tumour control was achieved in the majority of dogs. This protocol is reasonable to prescribe in older patients or when financial limitations exist.
Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Albany Creek, Queensland, Australia.
M B J
MBJ
Kung
Animal Cancer Centre, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
V J
VJ
Poirier
Department of Biomedical Sciences, Ross University School of Veterinary Medicine, St. Kitts, West Indies.
M M
MM
Dennis
School of Veterinary Medicine and the Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
D M
DM
Vail
Australian Animal Cancer Foundation, Brisbane Veterinary Specialist Centre, Albany Creek, Queensland, Australia.
R C
RC
Straw
D000818:Animals; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000473:pathology / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D008297:Male; D000069473:Radiation Dose Hypofractionation; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*
dog; hypofractionated; megavoltage; microscopic; palliative; tumour