Allantoic, vitelline, and "hybrid" embryonic vestiges of the umbilical cord: an immunohistochemical study.
The embryonic origin of umbilical cord vestiges is well documented; however, their immunophenotype is unknown. This study was conducted to determine whether vitelline and allantoic remnants can be differentiated using immunohistochemical markers. All allantoic remnants were stained with p63 and were negative for CDX2, whereas the vitelline remnants stained with CDX2 and were negative for p63. An unexpected finding was a small number of morphologically ambiguous cases that stained with both markers in a complimentary manner. The term "hybrid" remnant is proposed for these remnants.
Mt. Sinai Medical Center of Miami, Miami, FL.
Alicia C
AC
Hirzel
John
J
Alexis
D000482:Allantois / Q000378:metabolism / Q000648:ultrastructure*; D015415:Biomarkers / Q000378:metabolism; D000071616:CDX2 Transcription Factor; D004801:Eosine Yellowish-(YS); D005260:Female; D015870:Gene Expression; D006416:Hematoxylin; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D013194:Staining and Labeling; D014470:Umbilical Cord / Q000378:metabolism / Q000648:ultrastructure*; D014817:Vitelline Membrane / Q000378:metabolism / Q000648:ultrastructure*
D015415:Biomarkers; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; C081876:CKAP4 protein, human; D018398:Homeodomain Proteins; D008565:Membrane Proteins; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin