KIAA1549:BRAF fusion gene in pediatric brain tumors of various histogenesis.
The KIAA1549:BRAF fusion gene is considered a driver genetic event in pilocytic astrocytoma. We investigated a series of 69 pediatric brain neoplasms of diverse histogenesis and grade using the RT-PCR and sequencing. We detected the KIAA1549:BRAF fusion gene in five of 34 non-PA tumors (14.7%), that is, one glioblastoma, one anaplastic astrocytoma, one anaplastic pleomorphic xanthoastrocytoma, 1 ependymoma, and 1 Atypical Teratoid Rhabdoid Tumor. Our study showed that the K-B, although uncommon, it can be detected in non-PA tumors of various histogenesis and grading.
Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University, Rome, Italy.
Manila
M
Antonelli
Manuela
M
Badiali
Loredana
L
Moi
Francesca R
FR
Buttarelli
Caterina
C
Baldi
Maura
M
Massimino
Marc
M
Sanson
Felice
F
Giangaspero
D000293:Adolescent; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics* / Q000378:metabolism; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D015514:Oncogene Proteins, Fusion; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
BrafV600E; H3F3A mutation; KIAA1549:BRAF fusion gene; pediatric brain tumors; pediatric gliomas