Trienamine-mediated asymmetric [4+2]-cycloaddition of α,β-unsaturated ester surrogates applying 4-nitro-5-styrylisoxazoles.
Highly enantioselective organocatalytic [4+2]-cycloaddition of in situ generated trienamines with 4-nitro-5-styrylisoxazoles as α,β-unsaturated ester surrogates is presented. The synthetic utility of this strategy is demonstrated by transforming the formed cycloadducts into optically active carboxylates.
Center for Catalysis, Department of Chemistry, Aarhus University, Langelandsgade 140, DK-8000 Aarhus C, Denmark. kaj@chem.au.dk.
Yang
Y
Li
Francisco Javier
FJ
López-Delgado
Danny Kaare Bech
DK
Jørgensen
Rune Pagh
RP
Nielsen
Hao
H
Jiang
Karl Anker
KA
Jørgensen