An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression.
A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course.
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Hye Seon
HS
Kang
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Hea Yon
HY
Lee
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Seung Joon
SJ
Kim
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Seok Chan
SC
Kim
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Young Kyoon
YK
Kim
Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Gyeong Sin
GS
Park
Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Kyo Young
KY
Lee
Department of Radiology, The Catholic University of Korea College of Medicine, Seoul, Korea.
Jung Im
JI
Jung
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.
Ji Young
JY
Kang
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008221:Lymphoid Tissue / Q000473:pathology*; D008223:Lymphoma / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D012075:Remission, Spontaneous; D020545:Respiratory Mucosa / Q000473:pathology*
D000970:Antineoplastic Agents
Lung; Marginal zone B-cell lymphoma; Spontaneous neoplasm regression