Discrete nanoparticle-BSA conjugates manipulated by hydrophobic interaction.
Nanoparticle-protein conjugates are promising probes for biological diagnostics as well as versatile building blocks for nanotechnology. Here we demonstrate a facile method to prepare nanoparticles bearing discrete numbers of BSA simply by physical adsorption and electrophoretic isolation, in which the specific amphiphilic properties of BSA play important roles and the number of adsorbed BSA molecules can also be manipulated by tuning the coating extent of nanoparticles by amphiphilic polymer.
School of Life Science, Inner Mongolia Agricultural University , 306 Zhaowuda Road, Hohhot 010018, China.
Ruibo
R
Zhong
Yushuang
Y
Liu
Ping
P
Zhang
Jingran
J
Liu
Guofen
G
Zhao
Feng
F
Zhang
D000327:Adsorption; D000818:Animals; D002417:Cattle; D057927:Hydrophobic and Hydrophilic Interactions; D053758:Nanoparticles / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D012710:Serum Albumin, Bovine
BSA; discrete conjugate; hydrophobic interaction; nanoparticle; physical adsorption