Amenorrhea as a rare drug-related adverse event associated with everolimus for pancreatic neuroendocrine tumors.
The patient was an asymptomatic 43-year-old woman. Abdominal ultrasonography and enhanced computed tomography showed a tumor lesion accompanied by multiple cystic changes in the liver and the pancreatic tail. Endoscopic ultrasound-fine needle aspiration was performed on the pancreatic tumor lesion and revealed pancreatic neuroendocrine tumor (PNET). As it was unresectable due to multiple liver metastases, the decision was made to initiate treatment with everolimus and transcatheter arterial chemoembolization. The patient ceased menstruating after the start of everolimus administration. When the administration was discontinued due to interstitial lung disease, menstruation resumed, but then again stopped with everolimus resumption. An association between everolimus and amenorrhea was highly suspected. Amenorrhea occurred as a rare adverse event of everolimus. As the younger women might be included in PNETs patients, we should put this adverse event into consideration.
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Yoshiaki
Y
Kawaguchi
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Atsuko
A
Maruno
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Yohei
Y
Kawashima
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Hiroyuki
H
Ito
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Masami
M
Ogawa
Yoshiaki Kawaguchi, Atsuko Maruno, Yohei Kawashima, Hiroyuki Ito, Masami Ogawa, Tetsuya Mine, Department of Gastroenterology, Tokai University School of Medicine, Isehara 259-1193, Japan.
Tetsuya
T
Mine
D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D000970:Antineoplastic Agents / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000032:analysis; D018278:Carcinoma, Neuroendocrine / Q000737:chemistry / Q000188:drug therapy* / Q000556:secondary; D016461:Chemoembolization, Therapeutic; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D000068338:Everolimus; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy; D008598:Menstruation / Q000187:drug effects; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives*; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D000068338:Everolimus; D020123:Sirolimus
Adverse event; Amenorrhea; Everolimus; Neuroendocrine tumor; Pancreas