Regenerative medicine for the treatment of Teno-desmic injuries of the equine. A series of 150 horses treated with platelet-derived growth factors.
OBJECTIVE
The aim of the present study was to evaluate the safety and the clinical outcome of platelet-rich plasma for the treatment of teno-desmic injures in competition horses.


METHODS
From January 2009 to December 2011, 150 sport horses suffering from teno-desmic injuries were treated with no-gelled platelet-concentrate.


RESULTS
No horse showed any major adverse reaction as a result of the procedure. Full healing was obtained for 81% of the horses. Twelve percent had clinical improvement and only 7% a failure. Eight percent of cases of relapse were observed. No statistically significant correlation existed between clinical outcome and the area of the lesion. A statistically significant correlation existed between the clinical outcome and the age of the horse.


CONCLUSIONS
Treatment with platelet-derived growth factors leads to the formation of a tendon with normal morphology and functionality, which translate in the resumption of the agonistic activity for the horses we treated.
Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy.
Marco
M
Scala
Department of Medical and Veterinary Sciences, University of Parma, Parma, Italy.
Silvia
S
Lenarduzzi
Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy.
Francesco
F
Spagnolo
Department of Plastic and Reconstructive Surgery, IRCCS Azienda Ospedaliera Universitaria San Martino, Istituto Nazionale Per La Ricerca Sul Cancro, Genova, Italy trapassomaria1984@gmail.com.
Maria
M
Trapasso
Department of Experimental Medicine, University of Genova, Genova, Italy.
Chiara
C
Ottonello
Department of Experimental Medicine, University of Genova, Genova, Italy.
Anita
A
Muraglia
Department of Computer and Information Science (DISI), University of Genova, Genova, Italy.
Annalisa
A
Barla
Margherita
M
Squillario
Paolo
P
Strada
D000818:Animals; D006734:Horse Diseases / Q000000981:diagnostic imaging / Q000628:therapy*; D006736:Horses; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D053657:Platelet-Rich Plasma; D044968:Regenerative Medicine / Q000379:methods*; D016896:Treatment Outcome; D014463:Ultrasonography; D014947:Wounds and Injuries / Q000662:veterinary*
D010982:Platelet-Derived Growth Factor
Regenerative medicine; platelet; platelet-concentrate; regenerative surgery; teno-desmic injuries; tissue regeneration