Radioligand imaging of α4β2* nicotinic acetylcholine receptors in Alzheimer's disease and Parkinson's disease.
The α4β2* nicotinic acetylcholine receptors (α4β2*-nAChR) are highly abundant in the human brain. As neuromodulators they play an important role in cognitive functions such as memory, learning and attention as well as mood and motor function. Post mortem studies suggest that abnormalities of α4β2*-nAChRs are closely linked to histopathological hallmarks of Alzheimer's disease (AD), such as amyloid aggregates/oligomers and tangle pathology and of Parkinson's disease (PD) such as Lewy body pathology and the nigrostriatal dopaminergic deficit. In this review we summarize and discuss nicotinic receptor imaging findings of 2-[18F]FA-85380 PET, [11C]nicotine PET and 5-[123I]IA-85380 SPECT studies investigating α4β2*-nAChR binding in vivo and their relationship to mental dysfunction in the brain of patients with AD and patients out of the spectrum of Lewy body disorders such as PD and Lewy body dementia (DLB). Furthermore, recent developments of novel α4β2*-nAChR-specific PET radioligands, such as (-)[18F]Flubatine or [18F]AZAN are summarized. We conclude that α4β2*-nAChR-specific PET might become a biomarker for early diagnostics and drug developments in patients with AD, DLB and PD, even at early or prodromal stages.
Department of Nuclear Medicine University of Leipzig, Leipzig, Germany - Osama.Sabri@medizin.uni-leipzig.de.
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Meyer
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Tiepolt
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Barthel
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Hesse
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Sabri
D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D001549:Benzamides; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications; D006801:Humans; D019964:Mood Disorders / Q000150:complications; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D011950:Receptors, Cholinergic / Q000378:metabolism; D011978:Receptors, Nicotinic / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
D001549:Benzamides; D015415:Biomarkers; D019086:Bridged Bicyclo Compounds, Heterocyclic; D019275:Radiopharmaceuticals; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic; C115362:fluoronorchloroepibatidine; C403531:nicotinic receptor alpha4beta2