The microbiology of chronic rhinosinusitis with and without nasal polyps.
CONCLUSIONS
Staphylococcus aureus, Streptococcus, Haemophilus, Enterobacter, and Corynebacterium appear to be more frequently associated with patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) than with patients with CRS without nasal polyps (CRSsNP) or control subjects. Furthermore, the isolation rate of Staphylococcus aureus appears to be much lower in Chinese CRSwNP patients compared with their caucasian counterparts.


OBJECTIVE
To compare the predominant bacteriologic profiles in middle meatus of patients with CRSwNP, those with CRSsNP, and control subjects.


METHODS
A total of 165 CRSwNP patients, 76 CRSsNP patients, and 44 control subjects were recruited into the study. Swab samples were obtained from the middle meatus during endoscopic sinus surgery and processed for the presence of aerobic and non-aerobic bacteria and fungi.


RESULTS
Mostly aerobic and facultative anaerobic bacteria were detected in the samples from all three study groups, of which the most common aerobic bacteria were coagulase-negative staphylococci, Corynebacterium species, Staphylococcus aureus, and Haemophilus influenzae. In contrast, comparatively few anaerobic bacteria and fungi were isolated from the three study groups. In CRSwNP patients, significantly more Gram-negative aerobic and facultative anaerobic bacteria were isolated from the subgroup with normal eosinophil numbers than from the subgroup with increased blood eosinophils (p = 0.005). Correspondence analysis showed coagulase-negative staphylococci to be closely associated with all three patient groups, whereas Staphylococcus aureus, Streptococcus, Haemophilus, Enterobacter, and Corynebacterium species were associated with CRSwNP patients.
Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University , Beijing.
Qinghua
Q
Liu
Xinxin
X
Lu
Mingyu
M
Bo
Hui
H
Qing
Xiangdong
X
Wang
Luo
L
Zhang
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology*; D009298:Nasal Polyps / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D012852:Sinusitis / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000150:complications / Q000175:diagnosis / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D014057:Tomography, X-Ray Computed; D055815:Young Adult
Chinese subjects; Microbiology; Staphylococcus aureus; endoscopy