Sequence variation of Epstein-Barr virus (EBV) BCRF1 in lymphomas in non-endemic areas of nasopharyngeal carcinoma.
To characterize the sequence variation and the potential implication of the Epstein-Barr virus (EBV) oncogene in lymphoma, BamHI-C fragment rightward reading frame 1 (BCRF1) was sequenced in different types of EBV-positive lymphoma in northern China, and polymorphisms were compared with previous variation data from other malignancies. The dominate subtype of BCRF1 in EBV-positive lymphoma was the B95-8 prototype, and a mutation in the signal peptide was more strongly associated with Hodgkin's lymphoma. The high conservation of BCRF1 in EBV-positive lymphoma suggests its important role in maintaining the basic biological activity and immunosuppressive functions of the virus.
Department of Medical Microbiology, Qingdao University Medical College, 38 Dengzhou Road, Qingdao, 266021, China.
Lu
L
Han
Lingling
L
Sun
Zhenzhen
Z
Zhao
Yan
Y
Chao
Zhifu
Z
Sun
Hui
H
Li
Bing
B
Luo
D000595:Amino Acid Sequence; D001483:Base Sequence; D002277:Carcinoma; D020031:Epstein-Barr Virus Infections / Q000821:virology; D014644:Genetic Variation; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006689:Hodgkin Disease / Q000821:virology*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000821:virology*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000821:virology*; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics*
C066460:BCRF1 protein, Human herpesvirus 4; D014764:Viral Proteins