Eccrine syringofibroadenomatosis of the reactive subtype occurring in chronic poorly-controlled psoriasis.
Eccrine syringofibroadenomatosis (ESFA) is a rare adnexal tumor with acrosyringeal differentiation. Clinically, it can be mistaken for granulomatous infections or malignancies such as squamous cell carcinoma. Despite the rarity of the condition, we recently encountered two cases of the reactive subtype, which occurred in patients with poorly controlled chronic psoriasis. Both patients presented with long-standing, thick verrucous lesions on the lower legs. The diagnosis was made after histological examination and exclusion of infectious and neoplastic disorders. As this is a reactive disorder, management is focused on treating the underlying condition. Unfortunately, psoriasis was difficult to manage in both our patients and they defaulted further treatment. It is important to recognize ESFA as it can be confused with infectious or malignant disorders.
National Skin Centre, 1, Mandalay Road, 308 205, Singapore.
Yee Kiat
YK
Heng
Jiun Yit
JY
Pan
Suat Hoon
SH
Tan
Hong Liang
HL
Tey
D000068879:Adalimumab / Q000627:therapeutic use; D006607:Adenoma, Sweat Gland / Q000150:complications* / Q000473:pathology; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D004439:Eccrine Glands; D018226:Fibroadenoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000150:complications; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy; D013544:Sweat Gland Neoplasms / Q000150:complications* / Q000473:pathology; D017211:Treatment Failure
D000893:Anti-Inflammatory Agents; D000068879:Adalimumab