Is there an association between liver type fatty acid binding protein and severity of preeclampsia?
OBJECTIVE
The aim of this study was to estimate the level of liver fatty acid binding protein (LFABP) in women with preeclampsia.


METHODS
A case-control study was conducted in 90 pregnant women who were divided into the following three groups: normal pregnancy (n = 30), mild-moderate preeclampsia (n = 30), and severe preeclampsia (n = 30). Maternal blood samples were obtained during an antenatal clinic visit in normal pregnant women, and at the time of diagnosis in women with preeclampsia. Serum LFABP levels were measured by the quantitative sandwich enzyme immunoassay technique.


RESULTS
Serum LFABP level was significantly higher in severe and mild-moderate preeclampsia groups than normal pregnancy group (1,709.90 ± 94.82, 1,614.93 ± 118.22, and 1,532.36 ± 140.98 pg/ml, respectively; p < 0.001). In multivariate analysis, the severity of preeclampsia was correlated with LFABP level [unadjusted odds ratio (95% confidence interval), 1.008 (1.003-1.012), p < 0.001 and LDH 1.063 (1.029-1.099), p < 0.001].


CONCLUSIONS
Maternal serum LFABP level appears to be correlated with the severity of the preeclampsia and can be used to confirm the diagnosis.
Obstetrics and Gynecology Department, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey, ozlemuzunlars@hotmail.com.
Ozlem
O
Uzunlar
Yaprak
Y
Engin-Ustun
Sebnem
S
Ozyer
Nuri
N
Danısman
Tuba
T
Candar
Senem M
SM
Keskin
Leyla
L
Mollamahmutoglu
D000328:Adult; D016022:Case-Control Studies; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011247:Pregnancy; D012720:Severity of Illness Index
D050556:Fatty Acid-Binding Proteins; D007770:L-Lactate Dehydrogenase