Current position of high-resolution MS for drug quantification in clinical & forensic toxicology.
This paper reviews high-resolution MS approaches published from January 2011 until March 2014 for the quantification of drugs (of abuse) and/or their metabolites in biosamples using LC-MS with time-of-flight or Orbitrap™ mass analyzers. Corresponding approaches are discussed including sample preparation and mass spectral settings. The advantages and limitations of high-resolution MS for drug quantification, as well as the demand for a certain resolution or a specific mass accuracy are also explored.
Department of Experimental & Clinical Toxicology, Institute of Experimental & Clinical Pharmacology & Toxicology, Saarland University, D-66421 Homburg (Saar), Germany.
Markus R
MR
Meyer
Andreas G
AG
Helfer
Hans H
HH
Maurer
D000818:Animals; D019963:Clinical Chemistry Tests / Q000379:methods*; D053593:Forensic Toxicology / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*
D004364:Pharmaceutical Preparations