Lipase-supported metal-organic framework bioreactor catalyzes warfarin synthesis.
A green and sustainable strategy synthesizes clinical medicine warfarin anticoagulant by using lipase-supported metal-organic framework (MOF) bioreactors (see scheme). These findings may be beneficial for future studies in the industrial production of chemical, pharmaceutical, and agrochemical precursors.
Chung Yuan Christian University, 200, Chung-Pei Rd., Chung-Li, 320 (Taiwan).
Wan-Ling
WL
Liu
Ni-Shin
NS
Yang
Ya-Ting
YT
Chen
Stephen
S
Lirio
Cheng-You
CY
Wu
Chia-Her
CH
Lin
Hsi-Ya
HY
Huang
D000925:Anticoagulants / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D019149:Bioreactors; D004800:Enzymes, Immobilized / Q000737:chemistry / Q000378:metabolism; D055772:Green Chemistry Technology; D008049:Lipase / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry; D014859:Warfarin / Q000737:chemistry / Q000378:metabolism*
D000925:Anticoagulants; D004800:Enzymes, Immobilized; D009942:Organometallic Compounds; C509969:SBA-15; D014859:Warfarin; D012822:Silicon Dioxide; D008049:Lipase
green chemistry; lipase; metal-organic frameworks; physical adsorption; warfarin