HiJAKing T-ALL.
In the current issue of Blood, Degryse and coauthors report the transforming potential of a series of JAK3 mutations identified in primary T-cell acute lymphoblastic leukemia (T-ALL) samples and pave the way toward multitargeted JAK1 and JAK3 therapy in T-ALL.
INSTITUT NECKER ENFANTS-MALADES U1151.
Vahid
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Asnafi
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004195:Disease Models, Animal; D053613:Janus Kinase 1 / Q000378:metabolism*; D053616:Janus Kinase 3 / Q000235:genetics*; D015458:Leukemia, T-Cell / Q000235:genetics*; D008297:Male; D051379:Mice
D053613:Janus Kinase 1; D053616:Janus Kinase 3