Design and synthesis of a mitochondria-targeting carrier for small molecule drugs.
A novel mitochondria-targeting carrier QCy7HA was developed. QCy7HA transported the covalently attached doxorubicin (DOX) to mitochondria specifically. The conjugate limited the effects of P-glycoprotein (Pgp) efflux pumps of multidrug-resistant cells on DOX, indicating that diverting drugs to mitochondria is a potential promising method for treatment of drug-resistant cancers.
Department of Translational Imaging, Houston Methodist Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA.
Junyan
J
Han
Tae Hoon
TH
Lee
Ching-Hsuan
CH
Tung
Daniel Y
DY
Lee
D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
D004337:Drug Carriers; D054852:Small Molecule Libraries