Self-immolative phthalate esters sensitive to hydrogen peroxide and light.
Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro-fluorophore in cultured S2 cells.
Department of Chemistry, Iowa State University , 2101d Hach Hall, Ames, Iowa 50014, United States.
Kaitlyn M
KM
Mahoney
Pratik P
PP
Goswami
Aleem
A
Syed
Patrick
P
Kolker
Brian
B
Shannan
Emily A
EA
Smith
Arthur H
AH
Winter