Thermoresponsive self-assembly of nanostructures from a collagen-like peptide-containing diblock copolymer.
Temperature-triggered formation of nanostructures with distinct biological activity offers opportunities in selective modification of matrices and in drug delivery. Toward these ends, diblock polymers comprising poly(diethylene glycol methyl ether methacrylate) (PDEGMEMA) conjugated to a triple helix-forming collagen-like peptide were produced. Triggered by the collapse of the thermoresponsive domain above its LCST, the conjugate undergoes a reversible transition in aqueous solution to form well-defined nanovesicles with diameters of approximately 100 nm, with a transition temperature of 37 °C. The incorporation of CLP domains in these nanostructures may offer opportunities for the selective targeting of collagen-containing matrices.
Department of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Tianzhi
T
Luo
Lirong
L
He
Patrick
P
Theato
Kristi L
KL
Kiick
D000179:Acrylates / Q000737:chemistry; D002850:Chromatography, Gel; D002942:Circular Dichroism; D003094:Collagen / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D006358:Hot Temperature; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D050997:Nanomedicine / Q000379:methods / Q000639:trends; D049329:Nanostructures / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D022161:Transport Vesicles / Q000737:chemistry*
D000179:Acrylates; D046911:Macromolecular Substances; D010455:Peptides; D011108:Polymers; D011092:Polyethylene Glycols; D003094:Collagen
collagen-like peptide; drug delivery; self-assembly; thermoresponsive; vesicle