Implementing thrombosis guidelines in cancer patients: a review.
Venous thromboembolism is a frequent and serious complication in patients with cancer. It is an independent prognostic factor of death in cancer patients and the second leading cause of death, but physicians often underestimate its importance, as well as the need for adequate prevention and treatment. Management of venous thromboembolism in patients with cancer requires the coordinated efforts of a wide range of clinicians, highlighting the importance of a multidisciplinary approach. However, a lack of consensus among various national and international clinical practice guidelines has contributed to knowledge and practice gaps among practitioners, and inconsistent approaches to venous thromboembolism. The 2013 international guidelines for thrombosis in cancer have sought to address these gaps by critically re-evaluating the evidence coming from clinical trials and synthesizing a number of guidelines documents. An individualized approach to prophylaxis is recommended for all patients.
Assistance Publique-Hôpitaux de Paris, Internal Medicine and Vascular Disease Unit, Saint-Louis Hospital; Sorbonne Paris Cité, Paris 7 Diderot University, Paris, France;
Dominique
D
Farge-Bancel
Division of Angiology and Hemostasis, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland;
Henri
H
Bounameaux
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel;
Benjamin
B
Brenner
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, the Netherlands;
Harry R
HR
Büller
Thrombosis Research Institute and Queen Mary University of London, London, UK;
Ajay
A
Kakkar
Division of Hematology and Hemostaseology, Department of Internal Medicine, Medical University Vienna, Vienna, Austria;
Ingrid
I
Pabinger
Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Michael
M
Streiff
Institut Sainte Catherine, Avignon, France.
Philippe
P
Debourdeau
Anticoagulants; cancer; guidelines; thrombosis; venous thromboembolism