Reproductive toxicity of triptolide in male house rat, Rattus rattus.
The aim of study was to investigate the toxic effect of triptolide fed in bait on reproduction of male house rat, Rattus rattus. Feeding of cereal based bait containing 0.2% triptolide to male R. rattus for 5 days in no-choice feeding test, leading to mean daily ingestion of 20.45 mg/kg bw of triptolide, was found effective in significantly (P ≤ 0.05) reducing sperm motility and viability in cauda epididymal fluid by 80.65 and 75.14%, respectively, from that of untreated rats. Pregnancy rates were decreased by 100% in untreated cyclic female rats paired with male rats treated with 0.2% triptolide. Present studies suggest the potential of 0.2% triptolide bait in regulating reproductive output of R. rattus.
Department of Zoology, Punjab Agricultural University, Ludhiana 141004, India.
Neena
0000-0002-2078-475X
N
Singla
Department of Zoology, Punjab Agricultural University, Ludhiana 141004, India.
Swati
S
Challana
D000818:Animals; D000988:Antispermatogenic Agents / Q000633:toxicity*; D004224:Diterpenes / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects*; D004852:Epoxy Compounds / Q000633:toxicity; D005260:Female; D008297:Male; D010616:Phenanthrenes / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology; D013737:Testis / Q000187:drug effects*
D000988:Antispermatogenic Agents; D004224:Diterpenes; D004852:Epoxy Compounds; D010616:Phenanthrenes; C001899:triptolide