Early modulation of the cecal microbial activity in the young rabbit with rapidly fermentable fiber: impact on health and growth.
This study aimed at comparing various diets predicted to induce different stimulations of the cecal microbial activity of the young rabbit fed ad libitum from 16 to 70 d of age: i) a diet enriched with rapidly fermentable fiber expected to stimulate the cecal microbial activity (RFF group); ii) a control diet with a standard composition (C group); iii) and the same control diet with tiamulin and apramycin antibiotics, expected to inhibit the microbial activity (C+AB group). A total of 398 rabbits were used from 42 litters and weaned at 28 d of age. An in vivo digestibility trial was performed on 36 rabbits of 42 to 46 d of age housed in individual metabolic cages. The feed intake and growth rates were lower in the RFF group compared with the C+AB group (-15% in ADFI and -11% in ADG, P<0.001), with a lower weight of -183 g at 70 d (P<0.001). No significant difference was found on ADG and final BW between the RFF and the C groups, but the RFF diet allowed a better G:F ratio at postweaning (P<0.01). The digestion of soluble fiber (total dietary fiber minus NDF) was greater for the RFF group. The C+AB diet had a positive effect on the postweaning morbidity rate (P<0.05) but did not affect the mortality rate and the health risk index (morbidity and mortality). Conversely, the RFF diet appeared to reduce the mortality rate compared with the C+AB diet, especially before 41 d of age. Concerning the cecal microbial activity, a supply of RFF in the diet increased the cecal VFA concentrations (+28% vs. C+AB and +22% vs. C, P<0.001) and lowered the pH. The VFA pattern was affected at 45 and 60 d, with a dominance of acetate in the RFF group (+4% vs. C+AB and C groups, P<0.001) instead of butyrate in the C+AB and C groups (-3.6% and -5% vs. C+AB and C, respectively, P<0.001). Antibiotics addition (C+AB group) reduced the VFA concentration, but only after weaning (-25% at 45 d of age) without changing the fermentation pattern. In conclusion, early intake of RFF in young rabbits stimulated the cecal microbial activity, and reduced the voluntary feed intake, leading to a reduced G:F ratio.
INRA, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENSAT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENVT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31076 Toulouse, France.
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Jacquier
INRA, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENSAT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENVT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31076 Toulouse, France.
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Combes
INRA, UMR 1331 ToxAlim, Research Centre in Food Toxicology, F-31027 Toulouse Cedex 3, France Université de Toulouse INP, UMR 1331 ToxAlim, F-31000 Toulouse, France.
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Oswald
INRA, UMR 1313 Génétique Animale et Biologie Intégrative, F-78350 Jouy-en-Josas, France AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, F-78350 Jouy-en-Josas, France.
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Rogel-Gaillard
INRA, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENSAT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31326 Castanet-Tolosan, France Université de Toulouse INPT ENVT, UMR 1388 Génétique, Physiologie et Systèmes d'Elevage, F-31076 Toulouse, France thierry.gidenne@toulouse.inra.fr.
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Gidenne
D000367:Age Factors; D000821:Animal Feed / Q000032:analysis*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002432:Cecum / Q000187:drug effects / Q000382:microbiology*; D004032:Diet / Q000662:veterinary; D004043:Dietary Fiber / Q000378:metabolism / Q000494:pharmacology*; D004063:Digestion / Q000187:drug effects / Q000502:physiology*; D004224:Diterpenes; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D005285:Fermentation / Q000187:drug effects; D064307:Microbiota / Q000187:drug effects*; D009328:Nebramycin / Q000031:analogs & derivatives; D011817:Rabbits / Q000254:growth & development* / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004043:Dietary Fiber; D004224:Diterpenes; D005227:Fatty Acids; D009328:Nebramycin; C011666:apramycin; C014224:tiamulin
antibiotics; cecal activity; digestive health; fiber; performance traits; rabbit