Differential involvement of amygdala and cortical NMDA receptors activation upon encoding in odor fear memory.
Although the basolateral amygdala (BLA) plays a crucial role for the acquisition of fear memories, sensory cortices are involved in their long-term storage in rats. However, the time course of their respective involvement has received little investigation. Here we assessed the role of the glutamatergic N-methyl-d-aspartate (NMDA) receptors in the BLA and olfactory cortex at discrete moments of an odor fear conditioning session. We showed that NMDA receptors in BLA are critically involved in odor fear acquisition during the first association but not during the next ones. In the cortex, NMDA receptor activation at encoding is not necessary for recent odor fear memory while its role in remote memory storage needs further investigation.
Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, University Lyon1, Lyon, France.
Chloé
C
Hegoburu
Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, University Lyon1, Lyon, France.
Sandrine
S
Parrot
INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France Université de Bordeaux, Nutrition et Neurobiologie Intégrée, Bordeaux, France.
Guillaume
G
Ferreira
Centre de Recherche en Neurosciences de Lyon, INSERM U1028, CNRS UMR5292, University Lyon1, Lyon, France annemarie.mouly@cnrs.fr.
Anne-Marie
AM
Mouly
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D001245:Association Learning / Q000502:physiology; D066272:Basolateral Nuclear Complex / Q000187:drug effects / Q000502:physiology*; D002408:Catheters, Indwelling; D004597:Electroshock; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005239:Fear / Q000187:drug effects / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009812:Odorants; D066194:Olfactory Cortex / Q000502:physiology*; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*; D010812:Physical Stimulation; D020318:Rats, Long-Evans; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D015763:2-Amino-5-phosphonovalerate