[Bioinformatic analysis of mouse glucocorticoid-induced tumor necrosis factor receptor-related protein].
OBJECTIVE
To obtain the amino acid sequence of glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) of mouse with an attempt to predict the structure and function of GITR.


METHODS
The amino acid sequence of GITR was analyzed by bioinformatic methods using the network platforms and some bioinformatic softwares.


RESULTS
The amino acid sequence of mouse GITR showed a homology of 56% with that of other species, including human. GITR protein was composed of signal peptide, extracellular region, transmembrane domain and intracellular region. The extracellular region of mouse GITR is located at the position of 22-153 amino acid residues. The sequence of mGITR might contain four N-glycosylation sites, four serine phosphorylation sites, one threonine phosphorylation site and one tyrosine phosphorylation site.


CONCLUSIONS
The bioinformatic analysis of mouse GITR could provide a basis for the further expression and functional study of mouse GITR protein.
Department of Immunology, Institute of Clinical Laboratory Medicine, Jiangsu University, Zhenjiang Key Laboratory of Immunology, Zhenjiang 212013, China.
Pei
P
Shen
Department of Immunology, Institute of Clinical Laboratory Medicine, Jiangsu University, Zhenjiang Key Laboratory of Immunology, Zhenjiang 212013, China.
Zhaoliang
Z
Su
Department of Immunology, Institute of Clinical Laboratory Medicine, Jiangsu University, Zhenjiang Key Laboratory of Immunology, Zhenjiang 212013, China.
Shengjun
S
Wang
Department of Immunology, Institute of Clinical Laboratory Medicine, Jiangsu University, Zhenjiang Key Laboratory of Immunology, Zhenjiang 212013, China.
Huaxi
H
Xu
D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology; D053450:Glucocorticoid-Induced TNFR-Related Protein / Q000737:chemistry* / Q000502:physiology; D006031:Glycosylation; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010766:Phosphorylation; D017385:Sequence Homology
D053450:Glucocorticoid-Induced TNFR-Related Protein; C106544:Tnfrsf18 protein, mouse