Regression of choroidal neovascularization after vitrectomy for postinjection endophthalmitis.
OBJECTIVE
To report regression of choroidal neovascularization following vitrectomy for endophthalmitis after antivascular endothelial growth factor injections.


METHODS
Observational case series of two patients with exudative age-related macular degeneration.


RESULTS
Endophthalmitis developed 2 days after the fourth ranibizumab injection in 1 case and 1 day after the ninth bevacizumab injection in another case. Vitrectomy and intravitreal antibiotic injections were performed. There was no bacterial growth on the cultures. Postoperative fluorescein angiography and combined optical coherence tomography/scanning laser ophthalmoscopy showed regression of choroidal neovascularization that was sustained after 29 and 32 months follow-up.


CONCLUSIONS
In both patients with active exudative age-related macular degeneration, regression of choroidal new vessels occurred after vitrectomy and injection of intravitreal antibiotics for the treatment of endophthalmitis. Removal of the posterior vitreous during vitrectomy may have eliminated the contribution of vitreous to exudative age-related macular degeneration and choroidal neovascularization.
From the *Department of Ophthalmology, Tokyo Medical and Dental University, Tokyo, Japan; †Department of Neuro-Ophthalmology, Inouye Eye Hospital, Tokyo, Japan; ‡Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, Chicago, Illinois; §Doheny Eye Institute, University of Southern California, Los Angeles, California; and ¶VMR Institute, Huntington Beach, California.
Hirofumi
H
Emoto
Yuko
Y
Emoto
Jennifer I
JI
Lim
Alfredo A
AA
Sadun
J
J
Sebag