Detecting Optic Atrophy in Multiple Sclerosis Patients Using New Colorimetric Analysis Software: From Idea to Application.
Neuro-ophthalmologists typically observe a temporal pallor of the optic disc in patients with multiple sclerosis. Here, we describe the emergence of an idea to quantify these optic disc color changes in multiple sclerosis patients. We recruited 12 multiple sclerosis patients with previous optic neuritis attack and obtained photographs of their optic discs. The Laguna ONhE, a new colorimetric software using hemoglobin as the reference pigment in the papilla, was used for the analysis. The papilla of these multiple sclerosis patients showed greater pallor, especially in the temporal sector. The software detected the pallor and assigned hemoglobin percentages below normal reference values. Measurements of optic disc hemoglobin levels obtained with the Laguna ONhE software program had good ability to detect optic atrophy and, consequently, axonal loss in multiple sclerosis patients. This new technology is easy to implement in routine clinical practice.
a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .|b Aragones Institute of Health Sciences , Zaragoza , Spain , and.
Maria Pilar
MP
Bambo
a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .|b Aragones Institute of Health Sciences , Zaragoza , Spain , and.
Elena
E
Garcia-Martin
a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .|b Aragones Institute of Health Sciences , Zaragoza , Spain , and.
Susana
S
Perez-Olivan
a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .|b Aragones Institute of Health Sciences , Zaragoza , Spain , and.
José Manuel
JM
Larrosa-Povés
a Ophthalmology Department , Miguel Servet University Hospital , Zaragoza , Spain .|b Aragones Institute of Health Sciences , Zaragoza , Spain , and.
Vicente
V
Polo-Llorens
c Ophthalmology Department , University of La Laguna , La Laguna , Spain.
Manuel
M
Gonzalez-De la Rosa
D000465:Algorithms; D003124:Colorimetry; D003936:Diagnosis, Computer-Assisted; D003941:Diagnostic Techniques, Ophthalmological; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009103:Multiple Sclerosis / Q000175:diagnosis*; D009412:Nerve Fibers / Q000473:pathology; D009896:Optic Atrophy / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D010781:Photography; D011446:Prospective Studies; D012165:Retinal Ganglion Cells / Q000473:pathology; D012984:Software
D006454:Hemoglobins
Hemoglobin levels; multiple sclerosis; optic nerve head; optic neuritis attack; retinal nerve fiber layer; software