A Versatile Synthetic Extracellular Matrix Mimic via Thiol-Norbornene Photopolymerization.
Step-growth, radically mediated thiol-norbornene photopolymerization is used to create versatile, stimuli-responsive poly(ethylene glycol)-co-peptide hydrogels The reaction is cytocompatible and allows for the encapsulation of human mesenchymal stem cells with a viability greater than 95%. Cellular spreading is dictated via three-dimensional biochemical photopatterning.
Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Benjamin D
BD
Fairbanks
Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Michael P
MP
Schwartz
Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Alexandra E
AE
Halevi
Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Charles R
CR
Nuttelman
Department of Chemical and Biological Engineering University of Colorado Boulder, CO 80309-0424 (USA).
Christopher N
CN
Bowman
Department of Chemical and Biological Engineering and the Howard Hughes Medical Institute University of Colorado Boulder, CO 80309-0424 (USA).
Kristi S
KS
Anseth
hydrogels; photochemistry; polymeric materials; stimuli-responsive materials; tissue engineering