Effect of melatonin on cellular composition of the spleen and parameters of lipid metabolism in rats with alimentary obesity.
We studied the effects of melatonin on the status of immune organs and parameters of lipid metabolism in rats with alimentary obesity and parameters of lipid metabolism and immune status in Wistar rats kept on high-fat diet and receiving melatonin solution per os. Melatonin leveled the changes in blood and liver parameters of lipid metabolism, which was paralleled by normalization of cellular composition of immune organs. We conclude that melatonin can be a promising agent for the treatment of lipid metabolism and immune status disorders in alimentary obesity.
Research Institute of Physiology and Fundamental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.
V A
VA
Trufakin
A V
AV
Shurlygina
M I
MI
Dushkin
M V
MV
Khrapova
S V
SV
Michurina
E V
EV
Mel'nikova
N G
NG
Panteleeva
M V
MV
Tenditnik
D000818:Animals; D002784:Cholesterol / Q000097:blood; D059305:Diet, High-Fat / Q000009:adverse effects; D004353:Drug Evaluation, Preclinical; D005260:Female; D007155:Immunologic Factors / Q000494:pharmacology*; D007958:Leukocyte Count; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects; D008550:Melatonin / Q000494:pharmacology*; D009765:Obesity / Q000097:blood / Q000209:etiology / Q000276:immunology*; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D014280:Triglycerides / Q000097:blood
D007155:Immunologic Factors; D014280:Triglycerides; D002784:Cholesterol; D008550:Melatonin