The effect of mannitol administration to kidney donor on short-term outcomes of kidney transplantation.
As the cases of kidney transplant are increasing, the need to apply the factors to increase the success of transplant seems necessary. Mannitol increases the osmotic pressure and urine volume as a protective agent on renal tubules. We aimed to evaluate the effect of mannitol on short-term outcome of kidney transplantation by comparing two groups based on prescribing mannitol to donors. In a randomized clinical trial, 60 kidney recipients were assigned in two groups (30 in each), except that in one group donors received mannitol. They were studied with respect to age, gender, weight, blood urea nitrogen (BUN), creatinine (Cr), sodium (Na), potassium (K) and arterial blood gas (ABG) before and after surgery, and their pulse rate (PR) and blood pressure (BP) before, during and after surgery. Their urine volume was assessed in the operation room and the first 24 h after surgery. The short-term outcome, including BUN and Cr in the first 10 days after transplant, have been charted. Both the case (mannitol-positive donor patient) and the control (mannitol negative) groups were the same regarding the results gained for pre- and post-operative parameters. Follow-up assessments showed no significant differences in renal function. Based on this, we conclude that mannitol administration to donors does not have a beneficial effect on the prognosis and short-term outcome of transplantation on recipients; therefore, we feel that it should not be advised for kidney donors.
Anesthesiology and Urology Department, Modaress Hospital, Shadi Beheshti University of Medical Science, Tehran, Iran.
Hellieh Sadat
HS
Esfahani
Navid
N
Nooraei
Majeed
M
Asgary
Mohammad Reza
MR
Hashemian
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007492:Iran; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008353:Mannitol / Q000008:administration & dosage*; D008875:Middle Aged; D009392:Nephrectomy / Q000009:adverse effects; D013997:Time Factors; D016896:Treatment Outcome; D014554:Urination / Q000187:drug effects; D055815:Young Adult
D015415:Biomarkers; D008353:Mannitol; D003404:Creatinine