Protein kinases are potential targets to treat inflammatory bowel disease.
Protein kinases play a crucial role in the pathogenesis of inflammatory bowel disease (IBD), the two main forms of which are ulcerative colitis and Crohn's disease. In this article, we will review the mechanisms of involvement of protein kinases in the pathogenesis of and intervention against IBD, in terms of their effects on genetics, microbiota, mucous layer and tight junction, and the potential of protein kinases as therapeutic targets against IBD.
Lei Yang, Yutao Yan, School of Medicine, Hangzhou Normal University, Hangzhou 310036, Zhejiang Province, China.
Lei
L
Yang
Lei Yang, Yutao Yan, School of Medicine, Hangzhou Normal University, Hangzhou 310036, Zhejiang Province, China.
Yutao
Y
Yan
Barrier function; Genetics; Inflammatory bowel disease; Microbiota; Protein kinase