A sudden onset of a pseudo-neurological syndrome after HPV-16/18 AS04-adjuvated vaccine: might it be an autoimmune/inflammatory syndrome induced by adjuvants (ASIA) presenting as a somatoform disorder?
In last centuries, vaccines reduced the incidence of several infectious diseases. In last decades, some vaccines aimed at preventing also some cancers, where viruses play a causative role. However, several adverse events have been described after vaccines, but a causal relationship has been established only in a minority of cases. Here, we describe a pseudo-neurological syndrome occurred shortly after the administration of the bivalent HPV vaccine. Some autoimmune disorders, including neurological demyelinating diseases, have been reported after HPV vaccines, but the patient showed no organic lesions. The patient was diagnosed as having a functional somatoform syndrome, which was supposed to be autoimmune/inflammatory syndrome induced by adjuvants (ASIA), seen the temporal link with vaccination and the presence of anti-phospholipid autoantibodies. Immunological mechanisms of vaccines-and of adjuvants-have not been completely elucidated yet, and although there is no evidence of statistical association with many post-vaccination events, a causal link with vaccine cannot be excluded in some individuals.
Department of Pediatrics, Azienda Ospedaliera di Melegnano, Milan, Italy, dimimedpv@yahoo.it.
Dimitri
D
Poddighe
Lucia
L
Castelli
Gian Luigi
GL
Marseglia
Paola
P
Bruni
D000536:Aluminum Hydroxide; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000209:etiology*; D008050:Lipid A / Q000031:analogs & derivatives*; D053918:Papillomavirus Vaccines / Q000009:adverse effects* / Q000276:immunology*; D013001:Somatoform Disorders / Q000175:diagnosis; D013577:Syndrome
C532963:ASO4 mixture; D008050:Lipid A; D053918:Papillomavirus Vaccines; D000536:Aluminum Hydroxide