[Effect of 17β-estradiol on bioenergetic processes in the heart mitochondria of ovariectomized rats with insulin resistance].
Тhe bioenergetic processes in the heart mitochondria of Wistar rats with fructose-induced insulin resistance was investigated in female animals with different estrogen status. Respiration studies on isolated heart mitochondria by the polarographic method revealed that estrogen deficiency reduced complex IV activity, while its combination with high-fructose diet induced additional disturbances in the coupling of respiration and oxidative phosphorylation at the level of complex I of the electron transport chain. Exogenous 17b-estradiol inhibited the development of mitochondrial dysfunction in cardiomyocytes of ovariectomized rats with insulin resistance.
N I
NI
Gorbenko
A Y
AY
Borikov
O V
OV
Ivanova
E V
EV
Taran
T S
TS
Zvyagina
D000818:Animals; D019069:Cell Respiration / Q000187:drug effects*; D004032:Diet; D042967:Electron Transport Complex I / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000378:metabolism; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000633:toxicity; D007333:Insulin Resistance; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism; D010052:Ovariectomy; D010085:Oxidative Phosphorylation; D051381:Rats; D017208:Rats, Wistar
D004967:Estrogens; D005632:Fructose; D004958:Estradiol; D003576:Electron Transport Complex IV; D042967:Electron Transport Complex I
17b-estradiol; cardiomyocytes; estrogen deficiency; insulin resistance; mitochondrial dysfunction