Recent evidence of underestimated circulation of hepatitis C virus intergenotypic recombinant strain RF2k/1b in the Rhône-Alpes region, France, January to August 2014: implications for antiviral treatment.
Since the beginning of 2014, hepatitis C virus (HCV) recombinant forms RF2k/1b have been detected in the Rhône-Alpes French region in 10 patients originating from the Caucasus area. Circulation of this particular HCV strain is very likely to be underestimated. It is also prone to be misgenotyped when using genotyping methods based on the 5' region of the viral genome, which may lead to suboptimal treatment.
Laboratoire de Virologie, Hopital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.
C
C
Ramière
P
P
Tremeaux
A
A
Caporossi
M A
MA
Trabaud
F
F
Lebossé
F
F
Bailly
M A
MA
Thélu
J
J
Nana
V
V
Leroy
P
P
Morand
P
P
André
S
S
Larrat
D000998:Antiviral Agents / Q000627:therapeutic use; D001483:Base Sequence; D005602:France; D016679:Genome, Viral; D005838:Genotype; D016174:Hepacivirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D006526:Hepatitis C / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D016896:Treatment Outcome; D017361:Viral Nonstructural Proteins / Q000235:genetics
D000998:Antiviral Agents; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins