Self-assembled levan nanoparticles for targeted breast cancer imaging.
We report on the targeted imaging of breast cancer using self-assembled levan nanoparticles. Indocyanine green (ICG) was encapsulated in levan nanoparticles via self-assembly. Levan-ICG nanoparticles were found to be successfully accumulated in breast cancer via specific interaction between fructose moieties in levan and overexpressed glucose transporter 5 in breast cancer cells.
BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea. chungbh@kribb.re.kr.
Sun-Jung
SJ
Kim
Pan Kee
PK
Bae
Bong Hyun
BH
Chung
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism; D045744:Cell Line, Tumor; D005260:Female; D005630:Fructans / Q000737:chemistry*; D005632:Fructose / Q000737:chemistry / Q000378:metabolism; D051296:Glucose Transporter Type 5 / Q000378:metabolism; D006801:Humans; D007208:Indocyanine Green / Q000737:chemistry; D051379:Mice; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000737:chemistry*; D061848:Optical Imaging; D010316:Particle Size; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D005630:Fructans; D051296:Glucose Transporter Type 5; D005632:Fructose; C072599:levan; D007208:Indocyanine Green