A new approach for ovarian stimulation in IVF using Corifollitropin Alfa in combination with GnRH analogues to trigger final oocyte maturation. A pilot study.
A pilot study of 10 patients undergoing IVF stimulation, using the new combination of Corifollitropin Alfa with highly purified hMG and GnRH antagonists has been performed, whereas final oocyte maturation was induced by GnRH analogues. The hormonal profiles were analyzed, as well as the clinical outcome. All patients were recruited between March 1st 2013 and June 30(th) 2013. They were all younger than 38 years, had a normal BMI (between 18,0 and 32,0) and did not have more than three previous IVF stimulations. The combination of long acting FSH with hphMG, and under protection of GnRH antagonists against spontaneous LH-surge, provided a normal hormonal profile for estradiol, progesterone, LH, and FSH. The average oocyte quality and embryo quality were excellent, which resulted in four pregnancies out of ten. We conclude that the described combination is a safe, efficient, and patient friendly alternative for the classical IVF stimulation.
IVF Centrum, AZ Jan Palfijn Hospital, Henri Dunantlaan 5, 9000 Gent, Belgium.
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Decleer
IVF Centrum, AZ Jan Palfijn Hospital, Henri Dunantlaan 5, 9000 Gent, Belgium.
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Osmanagaoglu
Onze Lieve Vrouw Ziekenhuis, dienst Gynaecologie, Moorselbaan 164, 9300 Aalst, Belgium.
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Meganck
Centre for Reproductive Medicine, Dutch-speaking Free University Brussels, Laarbeeklaan 101, 1090 Brussels, -Belgium and AZ Jan Palfijn Hospital, Henri Dunantlaan 5, 9000 Gent, Belgium.
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Devroey
Corifollitropin Alfa; GnRH analogue triggering; IVF; hCG support luteal phase; ovarian stimulation