Detection of human bocavirus in children with acute respiratory tract infections in Lanzhou and Nanjing, China.
OBJECTIVE
The aim of this study was to explore the prevalent characteristics of HBoV1 and its co-infection.


METHODS
PCR was used to detect HBoV1-DNA (HBoV1) and other viruses. A multivariate logistic regression model was used to explore possibility of co-detected for related viruses.


RESULTS
The positivity rates in Nanjing and Lanzhou were 9.38% (74/789) and 11.62% (161/1386), respectively (P>0.05). The HBoV1 positive group was younger than negative group (P<0.05). Seasonal differences were noted, with a higher frequency of infection in December and July. HBoV1-positive children [72.34% (169/235)] were co-infected with other respiratory viruses. Multifactorial analysis showed no correlations between HBoV1 and the clinical classification, region, gender, age, or treatment as an outpatient or in a hospital. Correlations were identified between HBoV1 infections with ADV (OR=1.53, 95% CI 1.03-2.28), RSV (OR=0.71, 95% CI 0.52-0.98), and IFVA (OR=1.77, 95% CI 1.00-3.13).


CONCLUSIONS
Presence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender, although the prevalence of HBoV1 was higher in younger children. There were no correlations between HBoV1 and other variables, except for the season and ADV, RSV, or IFVA infections.
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Jian Jun
JJ
Wu
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; Nanjing Children's Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu, China.
Yu
Y
Jin
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Na
N
Lin
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Zhi Ping
ZP
Xie
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Jie Mei
JM
Yu
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Jin Song
JS
Li
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Chang Qing
CQ
Cao
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Xin Hui
XH
Yuan
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Jin Rong
JR
Song
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Jing
J
Zhang
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Yang
Y
Zhao
School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu, China; National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Xiao Qian
XQ
Gao
National Institute for Viral Disease Control and Prevention, China CDC, Beijing 100052, China.
Zhao Jun
ZJ
Duan
D000208:Acute Disease; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D056661:Human bocavirus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology*
D004279:DNA, Viral
Child; Human bocavirus; Respiratory tract infections