Bile salts-containing vesicles: promising pharmaceutical carriers for oral delivery of poorly water-soluble drugs and peptide/protein-based therapeutics or vaccines.
Most of the new drugs, biological therapeutics (proteins/peptides) and vaccines have poor performance after oral administration due to poor solubility or degradation in the gastrointestinal tract (GIT). Though, vesicular carriers exemplified by liposomes or niosomes can protect the entrapped agent to a certain extent from degradation. Nevertheless, the harsh GIT environment exemplified by low pH, presence of bile salts and enzymes limits their capabilities by destabilizing them. In response to that, more resistant bile salts-containing vesicles (BS-vesicles) were developed by inclusion of bile salts into lipid bilayers constructs. The effectiveness of orally administrated BS-vesicles in improving the performance of vesicles has been demonstrated in researches. Yet, these attempts did not gain considerable attention. This is the first review that provides a comprehensive overview of utilizing BS-vesicles as a promising pharmaceutical carrier with a special focus on their successful applications in oral delivery of therapeutic macromolecules and vaccines. Insights on the possible mechanisms by which BS-vesicles improve the oral bioavailability of the encapsulated drug or immunological response of entrapped vaccine are explained. In addition, methods adopted to prepare and characterize BS-vesicles are described. Finally, the gap in the scientific researches tackling BS-vesicles that needs to be addressed is highlighted.
a Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Cairo , Egypt.
Mona Hassan
MH
Aburahma
D000284:Administration, Oral; D001647:Bile Acids and Salts / Q000737:chemistry / Q000378:metabolism*; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D012995:Solubility; D014612:Vaccines / Q000737:chemistry* / Q000276:immunology / Q000627:therapeutic use*; D014867:Water / Q000737:chemistry*
D001647:Bile Acids and Salts; D004337:Drug Carriers; D008051:Lipid Bilayers; D008081:Liposomes; D010455:Peptides; D014612:Vaccines; D014867:Water
Bile salts; bile salts-containing liposomes; bilosomes; immune response; lipophilic drugs; proteins and peptides; vesicular carriers