[Determination of von Willebrand factor multimers in Mexican population].
BACKGROUND
Von Willebrand disease is an inherited disease in which the structure, function, and concentration of von Willebrand factor are altered, as well as the platelet von Willebrand factor endothelium interaction. In Mexico there are no epidemiological records of the disease. Only a few isolated studies have been reported from the clinical and hematological standpoint.


METHODS
We studied 155 Mexican Mestizos: 75 with presumptive diagnosis of von Willebrand disease, 15 with suspected diagnosis ofhemophilia A and 65 healthy donors (controls). Basic coagulation tests, special tests and classification test (analysis of multimeric composition) were carried out.


RESULTS
There were 15 patients with clinical diagnosis of hemophilia A, 75 patients with suspected von Willebrand disease of which 50 were diagnosed as the following types and subtypes: Type 1 (62%), Type 2 (22%) [subtypes: 2A (14%), 2B (2%), and 2N (6%)] and Type 3 (16%).


CONCLUSIONS
It has been reported that analysis of von Willebrand factor is a method that meets the characteristics for the diagnosis of von Willebrand disease. It is necessary to implement this methodology to study and improve the specific diagnoses.
Servicio de Genética, Instituto Nacional de Rehabilitación, Mexico.
Edgar
E
Hernández-Zamora
Laboratorio Central de Patología Clínica, Instituto Nacional de Rehabilitación, Mexico.
Cesar
C
Zavala-Hernández
Laboratorio de Hemostasia y Biología Vascular, Facultad de Ciencias Médicas y Biológicas Dr. Ignacio Chávez, Universidad Michoacana de San Nicolás de Hidalgo, Mexico DF, Mexico.
Martha Eva
ME
Viveros-Sandoval
Laboratorio de Hemostasia y Biología Vascular, Facultad de Ciencias Médicas y Biológicas Dr. Ignacio Chávez, Universidad Michoacana de San Nicolás de Hidalgo, Mexico DF, Mexico.
Angeles
A
Ochoa-Rico
Clínica de Hemostasia y Trombosis, Hospital General de México Eduardo Liceaga, México DF, Mexico.
Carlos
C
Martínez-Murillo
Laboratorio de Hemostasia y Biología Vascular, Facultad de Ciencias Médicas y Biológicas Dr. Ignacio Chávez, Universidad Michoacana de San Nicolás de Hidalgo, México, DF, Mexico. elbareyesm@gmail.com.
Elba
E
Reyes-Maldonado
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D055503:Protein Multimerization; D012189:Retrospective Studies; D055815:Young Adult; D014842:von Willebrand Diseases / Q000097:blood*; D014841:von Willebrand Factor / Q000032:analysis*
D014841:von Willebrand Factor
Multimers of vWF; enfermedad de von Willebrand; multímeros del factor de von Willebrand; von Willebrand disease