Malignant transformation of persistent endometriosis after hysterectomy.
The malignant transformation of persistent endometriotic implants into endometrioid adenocarcinoma is rare, especially after remote hysterectomy and salpingo-oophorectomy (TAH-BSO), and there are few cases reported in the English language literature. Patients receiving estrogen replacement therapy are common among the reported cases. We present a case that demonstrates the possibility of malignant transformation in a 53-year-old female, known case of endometriosis, who underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy with no evidence of malignancy in the final pathology report. After 9 years, she presented with lower abdominal mass, and histopathological studies confirmed the diagnosis of well-differentiated endometrioid adenocarcinoma. The possibility of malignant transformation and possible risk factors are discussed with a brief literature review.
Faculty of Medicine, Umm Alqura University, PO Box 1129, Makkah 21955, Kingdom of Saudi Arabia. Tel. +966 (12) 5556644. E-mail. naifbm@hotmail.com.
Naif A
NA
Bawazeer
Hatim M
HM
Al-Jifree
Abdulrahim M
AM
Gari
D000008:Abdominal Neoplasms / Q000150:complications*; D018269:Carcinoma, Endometrioid / Q000150:complications*; D002471:Cell Transformation, Neoplastic; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D010052:Ovariectomy; D058994:Salpingectomy