Utility of measuring (1,3)-β-d-glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection.
(1-3)-β-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
Division of Neurological Infections, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jennifer L
JL
Lyons
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kiran T
KT
Thakur
Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Rick
R
Lee
Division of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Tonya
T
Watkins
Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Carlos A
CA
Pardo
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Kathryn A
KA
Carson
Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
Barbara
B
Markley
Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
Malcolm A
MA
Finkelman
Division of Infectious Disease, Departments of Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Kieren A
KA
Marr
Indiana University, Indianapolis, Indiana, USA.
Karen L
KL
Roos
Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA Division of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA szhang28@jhmi.edu.
Sean X
SX
Zhang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D020314:Central Nervous System Fungal Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011509:Proteoglycans; D055815:Young Adult; D047071:beta-Glucans / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K