A model for time to fracture with a shock stream superimposed on progressive degradation: the Study of Osteoporotic Fractures.
Osteoporotic hip fractures in the elderly are associated with a high mortality in the first year following fracture and a high incidence of disability among survivors. We study first and second fractures of elderly women using data from the Study of Osteoporotic Fractures. We present a new conceptual framework, stochastic model, and statistical methodology for time to fracture. Our approach gives additional insights into the patterns for first and second fractures and the concomitant risk factors. Our modeling perspective involves a novel time-to-event methodology called threshold regression, which is based on the plausible idea that many events occur when an underlying process describing the health or condition of a person or system encounters a critical boundary or threshold for the first time. In the parlance of stochastic processes, this time to event is a first hitting time of the threshold. The underlying process in our model is a composite of a chronic degradation process for skeletal health combined with a random stream of shocks from external traumas, which taken together trigger fracture events.
Department of Epidemiology and Biostatistics, University of Maryland, College Park, MD 20742, U.S.A.
Xin
X
He
G A
GA
Whitmore
Geok Yan
GY
Loo
Marc C
MC
Hochberg
Mei-Ling Ting
ML
Lee
D000368:Aged; D056808:Biostatistics / Q000379:methods; D018450:Disease Progression; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D015233:Models, Statistical; D010024:Osteoporosis / Q000150:complications*; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012307:Risk Factors; D013269:Stochastic Processes; D016019:Survival Analysis; D013997:Time Factors
disease progression; elderly; first hitting time; health process; threshold regression; time-to-event data