Neuroprotective effect of potassium comenate against glutamate toxicity on the model of cultured rat cerebellar neurons.
The study demonstrated neuroprotective action of novel chemical agent, potassium salt of comenic acid, against the glutamate-induced cytotoxicity on the model of cultured cerebral neurons. Potassium comenate (0.001-1.0 mM) significantly decreased the rate of glutamateinduced neuronal death. The highest viability of the cultured neurons during postglutamate time was observed when potassium comenate was applied in a concentration of 0.1 mM.
A. Ya. Shurygin Department of Biologically Active Substances, Kuban State University, Krasnodar, Russia, balizfarm@mail.ru.
L V
LV
Shurygina
A A
AA
Kravtsov
E I
EI
Zlishcheva
E A
EA
Nemchinova
D Yu
DY
Bukin
D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology*; D004353:Drug Evaluation, Preclinical; D018698:Glutamic Acid / Q000633:toxicity*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D011753:Pyrones / Q000494:pharmacology*; D017208:Rats, Wistar
D002264:Carboxylic Acids; D018696:Neuroprotective Agents; D011753:Pyrones; C488376:comenic acid; D018698:Glutamic Acid