Glomus-like bodies within a neurofibroma: a novel neoplasm arising in neurofibromatosis type 1 or a coincidence?
Neurofibromatosis type 1 is a relatively common genetic disorder with variable phenotypes. Tumors with features of both glomus tumors and neurofibromas are exceedingly rare in literature. Herein, we report a not yet described neoplasm with features of both a glomangioma/glomus tumor and a neurofibroma arising in a patient with segmental neurofibromatosis. Our case report supports the theory of a common lineage/ancestor cell between neurofibromas and glomus tumors and adds it to the spectrum of neoplasms that may arise in the setting of Von Recklinghausen's disease.
Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL, USA.
Sumeet
S
Thareja
Alexis
A
Honigbaum
Drazen
D
Jukic
D003937:Diagnosis, Differential; D005918:Glomus Tumor / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009383:Neoplasms, Vascular Tissue / Q000473:pathology*; D009432:Neural Crest / Q000473:pathology; D009455:Neurofibroma / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009456:Neurofibromatosis 1 / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology
cutaneous neoplasm; dermatopathology; histology; neural crest; pathology