Heavier alkaline earth catalyzed ene-yne cyclizations: atom-efficient access to tetrahydroisoquinoline frameworks.
Tetrahydroisoquinoline frameworks may be accessed with 100% atom efficiency through the alkaline earth catalyzed addition of primary amines to ene-yne substrates through a sequence of intermolecular alkene and intramolecular alkyne hydroamination steps.
Department of Chemistry, Imperial College London , Exhibition Road, South Kensington, London SW7 2AZ, U.K.
Stephanie
S
Reid
Anthony G M
AG
Barrett
Michael S
MS
Hill
Panayiotis A
PA
Procopiou
D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D000475:Alkenes; D000480:Alkynes; D000588:Amines; D044005:Tetrahydroisoquinolines