Prognostic role of troponin and natriuretic peptides as biomarkers for deterioration of left ventricular ejection fraction after chemotherapy.
Cardiotoxicity due to anthracyclines, trastuzumab and other potential cardiotoxic drugs is still a problem of modern chemotherapy. For years researchers have tried to find biological markers that can predict changes in the heart. The most thoroughly tested markers are troponin and natriuretic peptides. Some studies have proven that these markers can indeed be useful. In studies which have shown the predictive role of troponin I the assessment of this marker was performed very frequently. It is not possible to carry out such serial measurements in many centers because of typical 1-day hospital stay times. The predictive role of natriuretic peptides still needs further investigation. This review considers the newest research from recent years.
Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Paweł
P
Stachowiak
Department of Cardiology, Pomeranian Medical University, Szczecin, Poland.
Zdzisława
Z
Kornacewicz-Jach
Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland.
Krzysztof
K
Safranow
biological markers; cardiotoxicity; chemotherapy; left ventricular dysfunction