[Oral bioavailability of oncological preparations: the intake conditions are often decisive].
The oral administration of pharmaceuticals plays an important role due to the many advantages, such as the simple administration and the associated high acceptance by patients. For modern oncological therapy in particular, the frequently encountered distribution of drug intake over morning, midday and evening is insufficient. Due to the sometimes highly significant food effect, the time of intake relative to mealtimes becomes of substantial importance. According to current knowledge the safest way to achieve as constant as possible resorption is to maintain strict rules with respect to intake times relative to food intake. Oral therapy with oncological drugs with pronounced food effects still raises the question how much the resorption is affected by simultaneous therapy with opioids.
Center of Drug Absorption and Transport, Institut für Pharmazie, Ernst-Moritz-Arndt-Universität Greifswald, Felix-Hausdorff-Straße 3, 17498, Neuenkirchen, Deutschland, werner.weitschies@uni-greifswald.de.
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D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001682:Biological Availability; D004435:Eating; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D065568:Oral Mucosal Absorption
D000970:Antineoplastic Agents