Inflammatory markers as mortality predictors in continuous ambulatory peritoneal dialysis patients.
OBJECTIVE
Besides peritonitis, the most common complication, indicators of chronic inflammation are also present in patients treated by peritoneal dialysis. The aim of this study was to analyze the predictive value of inflammatory parameters on mortality of continuous ambulatory peritoneal dialysis (CAPD) patients.


METHODS
Eighty-seven patients (57 males), aged from 30 to 85 [62.92 (10.61)] years who had been treated by a chronic program of CAPD for 3-113 months were analyzed. The basal period lasted 3 months with a follow-up of 30 months. Clinical parameters, dialysis adequacy and laboratory parameters including some inflammatory markers: serum amyloid-A (SAA), high sensitive C-reactive protein (hs-CRP), fibrinogen, erythrocyte sedimentation rate (ESR) and leukocytes were determined for each patient. Cox regression analysis selected the parameters of univariate and multivariate survival analysis.


RESULTS
During the follow-up period, 37 patients (42.5%) died. Univariate analysis selected the following potential mortality predictors (p<0.10): age, months on CAPD, residual urine output, presence of cerebrovascular insult (CVI), KT/V, serum urea and albumin concentrations, SAA, hs-CRP, fibrinogen and ESR. In the multivariate survival analysis four models were created, each with a single inflammatory parameter. In all of these models, besides the age and CVI, inflammatory parameters were the most significant mortality predictors. When the inflammatory markers were analyzed altogether, multivariate analysis established that independent mortality predictors in this group of patients were: SAA, age and CVI.


CONCLUSIONS
It may be concluded that in this studied group treated by CAPD, SAA was the most significant independent mortality predictor among the analyzed inflammatory markers.
Faculty of Medicine, University of Belgrade , Belgrade , Serbia and.
Dijana B
DB
Jovanovic
Milan D
MD
Stosović
Biljana M
BM
Gojakovic
Natasa Z
NZ
Jovanovic
Mirjana Lj
MLj
Stanojevic-Stosovic
Sanja P
SP
Simic-Ogrizovic
Radomir T
RT
Naumovic
D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy; D007677:Kidney Function Tests; D007958:Leukocyte Count / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods; D011237:Predictive Value of Tests; D055771:Serbia / Q000453:epidemiology; D016019:Survival Analysis
D015415:Biomarkers; D005340:Fibrinogen; D002097:C-Reactive Protein
C-reactive protein; CAPD; chronic inflammation; mortality; serum amyloid-A