Vitelliform macular detachment associated with Basal laminar drusen is unresponsive to vascular endothelial growth factor blockade.
OBJECTIVE
To determine whether vascular endothelial growth factor (VEGF) mediates the leakage in basal laminar drusen (BLD)-associated vitelliform macular detachment (VMD) and whether VEGF blockade can improve visual function in affected eyes.


METHODS
Interventional case report.


METHODS
A 46-year-old woman presented with decreased visual acuity in the right eye and BLD-associated VMD.


RESULTS
There was no improvement in visual acuity, fundus appearance, or findings of fluorescein angiography and optical coherence tomography after two intravitreal injections of anti-VEGF agents, suggesting that the exudation is not VEGF mediated.


CONCLUSIONS
Ophthalmologists should distinguish BLD-associated VMDs from age-related macular degeneration-associated choroidal neovascularization to avoid exposing patients to the risk of unnecessary intravitreal injections.
From the W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan.
Deborah Y
DY
Chong
Mark W
MW
Johnson