Retrospective review on the use of topical cyclosporin a 0.05% for paediatric allergic conjunctivitis in Hong Kong Chinese.
OBJECTIVE
To evaluate the efficacy of using topical cyclosporin A 0.05% (Restasis) for the treatment of paediatric allergic conjunctivitis.


METHODS
This retrospective study included consecutive cases of paediatric allergic conjunctivitis treated with Restasis between 2010 and 2013. Subjects with follow-up time less than 3 months after using Restasis were excluded. Itch severity score, symptom score, and sign score were compared before (baseline) and 3 months after using Restasis.


RESULTS
In 27 eyes of 14 patients (mean age 10.8 ± 3.2 years), 44.4% had allergic conjunctivitis, 33.3% had vernal keratoconjunctivitis, and 22.2% had atopic keratoconjunctivitis. The mean duration of ocular symptoms was 20.4 ± 13.2 months. 92.6% of subjects were using steroid eye drop before Restasis. After 3 months of topical Restasis, there were statistically significant reductions in the symptom, sign, and itch severity scores compared with baseline (all P ≤ 0.001) and 78.6% of subjects were able to be tapered off steroid eye drops.


CONCLUSIONS
Topical Restasis was effective and safe in significantly reducing ocular itchiness, sign, and symptom scores at 3 months after use in paediatric allergic ocular conditions.
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Macy M S
MM
Wu
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Gordon S K
GS
Yau
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Jacky W Y
JW
Lee
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Amy L
AL
Wong
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Victor T Y
VT
Tam
Department of Ophthalmology, Caritas Medical Center, 111 Wing Hong Street, Kowloon, Hong Kong.
Can Y F
CY
Yuen
D000287:Administration, Topical; D000293:Adolescent; D044466:Asian People; D002648:Child; D003233:Conjunctivitis, Allergic / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D006723:Hong Kong; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D012189:Retrospective Studies; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016572:Cyclosporine