Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals.
OBJECTIVE
To examine the relationship between inflammatory and coagulation biomarkers and cardiac autonomic function (CAF) as measured by heart rate variability in persons with HIV.


METHODS
This analysis included 4073 HIV-infected persons from the Strategies for Management of Antiretroviral Therapy study. We examined the association between IL-6, high-sensitivity C-reactive protein (hsCRP) and D-dimer with heart rate variability measures (SDNN and rMSSD), both cross-sectionally and longitudinally.


RESULTS
Cross-sectional analysis revealed significant inverse associations between IL-6, hsCRP and d-dimer with SDNN and rMSSD (p < 0.01 for all comparisons). However, longitudinal analysis failed to show a significant association between baseline IL-6, hsCRP and d-dimer with change in CAF over time.


CONCLUSIONS
Cross-sectionally, higher levels of inflammatory and coagulation biomarkers were associated with lower levels of CAF in the Strategies for Management of Antiretroviral Therapy trial. Although deterioration in CAF was observed during followup, baseline levels of inflammatory and coagulation markers were not predictive of the decline in CAF over time.
Center for Integrative Medicine, Wake Forest Baptist Health, Winston Salem, NC, USA.
Lari C
LC
Young
Mollie P
MP
Roediger
Greg
G
Grandits
Jason
J
Baker
Charurut
C
Somboonwit
Ian
I
Williams
Jens D
JD
Lundgren
James D
JD
Neaton
Elsayed Z
EZ
Soliman
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001777:Blood Coagulation; D002097:C-Reactive Protein; D003430:Cross-Sectional Studies; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D015658:HIV Infections / Q000097:blood* / Q000503:physiopathology / Q000628:therapy; D006329:Heart Conduction System / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; C036309:fibrin fragment D; D002097:C-Reactive Protein
HIV; IL-6; biomarkers; cardiac autonomic function; coagulation; d-dimer; heart rate variability; high-sensitivity C-reactive protein; inflammation