EphA3 biology and cancer.
Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic development, and are implicated in a range of processes including angiogenesis, stem cell maintenance and metastasis. They are thus of great interest as targets for cancer therapy. EphA3, originally isolated from leukemic and melanoma cells, is presently one of the most promising therapeutic targets, with multiple tumor-promoting roles in a variety of cancer types. This review focuses on EphA3, its functions in controlling cellular behavior, both in normal and pathological development, and most particularly in cancer.
Department of Biochemistry and Molecular Biology, Monash University , Victoria , Australia and.
Peter W
PW
Janes
Christopher I
CI
Slape
Rae H
RH
Farnsworth
Lakmali
L
Atapattu
Andrew M
AM
Scott
Mary E
ME
Vail
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D036081:Receptors, Eph Family / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D036081:Receptors, Eph Family
Cancer; cell-cell interaction; eph receptor; ephrin