Cutaneous B-lymphoblastic lymphoma with IL3/IgH translocation presenting with hypereosinophilia and acute endocarditis.
Hypereosinophilia is a rare phenomenon associated with childhood malignancy, predominantly acute lymphoblastic leukaemia. Causation is unclear and likely to have multiple mechanisms. We report a six year old boy presenting with hypereosinophilia and associated Loeffler endocarditis. Three months following his initial hypereosinophilia he developed cutaneous B-lymphoblastic lymphoma. Re-analysis of apparently uninvolved bone marrow, taken at initial presentation, revealed a single, previously unidentified, t(5;14)(q31;q32) positive cell. Using fluorescent in situ hybridisation, we demonstrate IL3/IgH@ fusion in cutaneous lymphoma cells. Our case confirms the association of hypereosinophilia and B-lymphoblastic lymphoma and strengthens the association between IL3 hypersecretion and hypereosinophilia.
Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK; Department of Paediatric Oncology, Newcastle upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK.
Simon
S
Bomken
Shaun
S
Haigh
Nick
N
Bown
Peter
P
Carey
Katrina
K
Wood
Kevin
K
Windebank
D000208:Acute Disease; D002648:Child; D002883:Chromosomes, Human, Pair 14; D002895:Chromosomes, Human, Pair 5; D004696:Endocarditis / Q000209:etiology*; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000209:etiology*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007377:Interleukin-3 / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000150:complications / Q000235:genetics*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains; D007377:Interleukin-3
IL3; cytogenetics; hypereosinophilia; lymphoblastic lymphoma; nonhodgkin's lymphoma; t(5; 14)