Early results of neurodevelopment following hybrid stage I for hypoplastic left heart syndrome.
Motor skills and neurodevelopment in infants with hypoplastic left heart syndrome (HLHS) who have undergone Hybrid Stage I palliation is unknown. The purpose of this study is to assess early neurodevelopment in infants with HLHS after Hybrid Stage I palliation. Developmental assessment was performed in HLHS infants who underwent Hybrid Stage I palliation at 2 and 4 months of age using the Test of Infant Motor Performance, and at 6 months of age, prior to undergoing the second staged surgery, using the Bayley Scales of Infant and Toddler Development, 3rd edition (Bayley-III). Results were compared to healthy control subjects and norm-referenced data. The HLHS group scored between -1 and -2 standard deviations (SD) below the mean at 2 months of age (p = 0.002), and within -1 SD of the mean, at 4 months of age (p = 0.0019), on the TIMP. Compared to the control group, composite motor skills were significantly lower at 6 months of age on the Bayley-III in the HLHS group (p = 0.0489), however, not significant for cognitive (p = 0.29) or language (p = 0.68). Percentile rank motor scores were 17 ± 20 % in the HLHS group compared to 85 ± 12 % for the healthy age-matched control group. Infants with HLHS who undergo Hybrid Stage I palliation score lower on standardized motor skill tests compared to healthy age-matched controls and the norm-referenced population. This suggests that infants with HLHS have poorer motor skill performance than typically developing infants at 6 months of age.
The Heart Center, Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA, Sharon.Cheatham@Nationwidechildrens.org.
Sharon L
SL
Cheatham
Helen
H
Carey
Joanne L
JL
Chisolm
Jill C
JC
Heathcock
Deborah
D
Steward
D002657:Child Development; D002663:Child Language; D003071:Cognition; D005260:Female; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D007223:Infant; D008297:Male; D009048:Motor Skills; D009483:Neuropsychological Tests; D010166:Palliative Care / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome