Serum lectin-like oxidized-low density lipoprotein receptor-1 and adiponectin levels are associated with coronary artery disease accompanied with metabolic syndrome.
BACKGROUND
Coronary artery disease (CAD) is a major public health problem for developed and developing countries and is the single leading cause of death worldwide.


OBJECTIVE
There is very few evidence regarding changes of both serum Lectin-like oxidized-low density lipoprotein receptor-1 (LOX-1) and adiponectin in patients with CAD accompanied with metabolic syndrome (MS). Here we aimed to evaluate serum levels of LOX-1 and adiponectin in patients with CAD accompanied with MS.


METHODS
Thirty patients with coronary artery disease without metabolic syndrome, 30 patients with coronary artery disease and metabolic syndrome, 30 ones with metabolic syndrome and 30 healthy subjects were enrolled. For all subjects, a questionnaire was filled to collect data, and peripheral blood samples were collected aseptically from the antecubital vein to measure serum Lectin-like oxidized-low density lipoprotein receptor-1 and adiponectin levels by enzyme-linked immunosorbent assay.


RESULTS
Serum LOX-1 level was highest in CAD + MS group; the difference between control and disease groups was statistically significant (P < 0.001). Adiponectin level had the lowest value in CAD + MS group; the difference between control and disease groups was statistically significant (P < 0.05). No significant differences were observed in serum Lectin-like oxidized-low density lipoprotein receptor-1and adiponectin in patients with different ages and gender. Serum LOX-1 level was changed negatively and linearly (R2 = 0.721) correlated with adiponectin level in different groups.


CONCLUSIONS
Patient with CAD and MS had higher risk than those with only CAD because of lipid and glucose metabolism abnormalities. Combination measurements of serum LOX-1 and adiponectin levels may be helpful to evaluate the severity of CAD together with MS.
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Ali Sheikh
AS
Md Sayed
Institute of Clinical Pharmacology, Central South University, Changsha, China.
Zhenyu
Z
Zhao
Xijing Hospital, Fourth Military Medical University, Xi An, China.
Lanyan
L
Guo
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Fei
F
Li
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Xu
X
Deng
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China.
Hai
H
Deng
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China ; Center for Vascular Biology and Inflammation, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical, Boston, USA.
Ke
K
Xia
Department of Cardiology, Xiangya Hospital, Central South University, Changsha, China ; Institute of Hypertension, Central South University, Changsha, China.
Tianlun
T
Yang
Adiponectin; Coronary Artery Disease; LOX-1; Metabolic Syndrome