Overexpression of eIF3e is correlated with colon tumor development and poor prognosis.
EIF3e is a component of the eukaryotic translation initiation factor 3 (eIF-3) complexes, which is an essential factor for initiation of protein synthesis in mammalian cells. Translational control plays key roles in the complex mechanism of cancer development and progression. However, the clinical significance of eIF3e in colon cancer remains to be elucidated. We analyzed the eIF3e expression in a tissue microarray (TMA), which contained 173 colon cancer tissues paired with adjacent normal mucosa and lymph node metastasis. The expression of eIF3e was significantly elevated in colon cancer tissues in comparison with those in adjacent normal mucosa (P < 0.001) and lymph node metastasis (P < 0.001). The high expression of eIF3e in colon cancer was significantly correlated with tumor size (P < 0.001), lymph node involvement (P < 0.001), distant metastasis (P < 0.001), clinical stage (P < 0.001), histopathologic classification (P < 0.001), and vessel invasion (P = 0.036). Univariate and multivariate analysis revealed that eIF3e is an independent prognosis factor for overall survival and disease-free survival in colon cancer. Down-regulation of eIF3e in vitro inhibited colon cancer cell proliferation, clonality and promoted cell apoptosis. Taken together, high eIF3e expression may contribute to tumor progression and predict poor prognosis in colon cancer.
Department of Anorectal Surgery, Qianfoshan Hospital Affiliated to Shandong University 16766 Jingshi Road, Jinan 250014, Shandong, China.
Zhi
Z
Li
Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, China.
Shengtao
S
Lin
Department of Anal-Colorectal Surgery, General Hospital of Ningxia Medical University 804 South Shengli Road, Yinchuan 750004, China.
Tao
T
Jiang
Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, China.
Jingtao
J
Wang
Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, China.
Huijun
H
Lu
Department of Pathology, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, China.
Huamei
H
Tang
Department of General Surgery, Qianfoshan Hospital Affiliated to Shandong University 16766 Jingshi Road, Jinan 250014, Shandong, China.
Mujian
M
Teng
Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital 85 Wujin Road, Shanghai 200080, China.
Junwei
J
Fan
D000368:Aged; D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D003082:Colectomy; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D018572:Disease-Free Survival; D039621:Eukaryotic Initiation Factor-3 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D045325:HCT116 Cells; D006801:Humans; D053208:Kaplan-Meier Estimate; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D034622:RNA Interference; D012333:RNA, Messenger / Q000378:metabolism; D013997:Time Factors; D014162:Transfection; D016896:Treatment Outcome; D015854:Up-Regulation
D014408:Biomarkers, Tumor; D039621:Eukaryotic Initiation Factor-3; D012333:RNA, Messenger
Colon cancer; apoptosis; clinicopathological features; eIF3e; prognosis; proliferation