Bioaccumulation of BDE-47 and effects on molecular biomarkers acetylcholinesterase, glutathione-S-transferase and glutathione peroxidase in Mytilus galloprovincialis mussels.
Mussels, Mytilus galloprovincialis, showed a high bioaccumulation ability when exposed to waterborne tetrabromodiphenyl ether (BDE-47), with a bioconcentration factor of 10,900 L Kg(-1) wet weight, and slow depuration rates in clean seawater. Kinetic and concentration-response experiments were performed measuring in the exposed mussel the activities of three molecular biomarkers: glutathione S-transferase (GST), glutathione peroxidase (GPx) and acetylcholinesterase (AChE). The long term (30 days) exposure of mussels to all concentrations (2-15 µg L(-1)) of BDE-47 significantly inhibited the AChE and GST activities, a result that supports the suitability of these biomarkers in marine pollution monitoring programs. However, GPx activity showed a less consistent pattern of response depending on the concentration and the duration of exposure.
Departamento de Ecoloxía e Bioloxía Animal, Universidade de Vigo, Estrada Colexio Universitario s/n, 36310, Vigo, Galicia, Spain, leticia1582@uvigo.es.
Leticia
L
Vidal-Liñán
Juan
J
Bellas
José
J
Fumega
Ricardo
R
Beiras
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004784:Environmental Monitoring; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D055768:Halogenated Diphenyl Ethers / Q000378:metabolism* / Q000494:pharmacology*; D049878:Mytilus / Q000187:drug effects* / Q000201:enzymology; D013030:Spain; D014874:Water Pollutants, Chemical / Q000378:metabolism / Q000494:pharmacology
D015415:Biomarkers; D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical; C511295:2,2',4,4'-tetrabromodiphenyl ether; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D000110:Acetylcholinesterase