Photodynamic therapy and vitrectomy for a large optic nerve hemangioma with neovascularization and retinal detachment: a clinicopathologic correlation.
OBJECTIVE
To report the clinicopathologic correlation of a young man with a von Hippel-Lindau disease-associated peripapillary hemangioblastoma and its satisfactory response to a combination of photodynamic therapy (PDT) and vitrectomy.


METHODS
Clinicopathologic correlation.


METHODS
We studied the case of a 14-year-old boy with an optic nerve mass and large inferior exudative retinal detachment complicated by a significant tractional component from extensive secondary neovascularization over the lesion.


RESULTS
A juxtapapillary hemangioblastoma with secondary neovascularization was documented by clinical examination, fundus photography, and optical coherence tomography. A von Hippel-Lindau gene mutation was detected. The patient responded satisfactorily to a combination of PDT and vitrectomy.


CONCLUSIONS
A staged approach to treatment of peripapillary hemangioblastoma with a combination of PDT and vitrectomy may be favorable to therapy with one modality.
From the Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miller School of Medicine, and the Florida Lions Ocular Pathology Laboratory, Miami, Florida.
Armando
A
Alegret
Colleen M
CM
Cebulla
Sander R
SR
Dubovy
Lejla
L
Mutapcic
Ditte J
DJ
Hess
Timothy G
TG
Murray