Hereditary breast cancer syndromes and genetic testing.
Only 5% of breast cancers are explained by highly penetrant multisystem autosomal dominant hereditary disorders. Though another 20-30% has a familial presentation, the genetic and other etiologies are still not well understood. Genetic testing is now widely available and multiple professional societies have published guidelines for testing and management. Genetic testing trends include utilization of multi-gene panels that take advantage of next-generation sequencing as well as testing for low- and moderate-penetrance susceptibility genes.
Clinical Cancer Genetics Program, Department of Surgical Oncology, M. D. Anderson Cancer Center, Houston, Texas.
Thereasa A
TA
Rich
Ashley H
AH
Woodson
Jennifer
J
Litton
Banu
B
Arun
D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D005820:Genetic Testing; D006801:Humans; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis* / Q000235:genetics*
BRCA1; BRCA2; genes; genetic counseling; hereditary/diagnosis; neoplastic syndromes; risk assessment