Tegafur-induced acral hyperpigmentation.
Tegafur is a prodrug of 5-fluorouracil (5-FU) with a similar spectrum of antitumor activity. It is used in the treatment of advanced gastrointestinal neoplasms. Over 5-FU, tegafur has the advantage of oral administration and less hematologic toxicity. Gastrointestinal toxicity is its main dose-limiting factor. The cutaneous adverse effects of tegafur include mucositis, photosensitivity, diffuse or nail-restricted hyperpigmentation, palmoplantar erythrodysesthesia syndrome, palmoplantar keratoderma, sclerodactyly and Raynaud phenomenon. We report here the case of a patient who developed acral hyperpigmentation during treatment with tegafur.
Department of Dermatology, Coimbra University Hospital, Portugal.
Vera
V
Teixeira
Department of Dermatology, Coimbra University Hospital, Portugal.
Ricardo
R
Vieira
Department of Dermatology, Coimbra University Hospital, Portugal.
Américo
A
Figueiredo
5-fluorouracil; acral hyperpigmentation.; tegafur