Multiresponsive hydrogel coassembled from phenylalanine and azobenzene derivatives as 3D scaffolds for photoguiding cell adhesion and release.
A multiresponsive hydrogel system coassembled from phenylalanine derivative gelator (LPF2) and azobenzene (Azo) derivative (PPI) is constructed, which can respond to temperature, pH, host-guest interaction, and photoirradiation. A set of techniques including circular dichroism, Fourier transform infrared spectroscopy, (1)H NMR, and X-ray powder diffraction confirm that the hydrogel is formed through hydrogen bonds between amide moieties/pyridine and carbonyl groups, enduing the coassembled hydrogel with multiresponsive properties that make it possible to control cell encapsulation and release in three-dimensional environments under multistimulus, for example, UV irradiation. This study brings a novel approach to develop multistimuli-responsive hydrogels by coassembly of various responsive components for biomedical interest, for example, the controlled delivery of various therapeutic biological agents.
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiaotong University , 800 Dongchuan Road, Shanghai 200240, China.
Guo-Feng
GF
Liu
Wei
W
Ji
Wan-Lin
WL
Wang
Chuan-Liang
CL
Feng
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry*; D002448:Cell Adhesion / Q000528:radiation effects; D018929:Cell Culture Techniques / Q000295:instrumentation*; D049109:Cell Proliferation / Q000528:radiation effects; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D041681:NIH 3T3 Cells; D010649:Phenylalanine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry*; D014466:Ultraviolet Rays
D001391:Azo Compounds; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D010649:Phenylalanine; C009850:azobenzene
cell release; coassembly; multiresponsive; supramolecular hydrogel; three-dimensional