Stress equips CLL cells to survive.
In this issue of Blood, Krysov et al demonstrate that B-cell receptor (BCR) signaling in chronic lymphocytic leukemia (CLL) results in partial activation of the unfolded protein response (UPR).
ERASMUS MC ROTTERDAM.
Rudi W
RW
Hendriks
D000077329:Agammaglobulinaemia Tyrosine Kinase; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D000072377:Syk Kinase; D056811:Unfolded Protein Response
D007075:Immunoglobulin M; D047908:Intracellular Signaling Peptides and Proteins; D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000606896:SYK protein, human; D000072377:Syk Kinase