Symptomatic Secondary Selective IgM Immunodeficiency in Adult Man with Undiagnosed Celiac Disease.
Selective IgM immunodeficiency (SIgMID) is a heterogeneous disorder with no known genetic background and may occur as a primary or a secondary condition. Celiac disease has been reported in association with several humeral immunodeficiencies, including isolated severe selective IgA deficiency, panhypogammaglobulinemia, and isolated combined IgA and IgM deficiency. There are only few reported cases of pediatric and adult patients with SIgMID and celiac disease. In this paper, we describe an adult patient with a symptomatic secondary SIgMID associated with undiagnosed celiac disease, with a resolution of clinical symptoms of immunodeficiency and serum IgM normalization following a gluten-free diet.
Leumit Health Services, Ashkelon, Israel ; Medicine B Department, Barzilai Medical Center, 78306 Ashkelon, Israel ; Allergy and Clinical Immunology Unit, Barzilai Medical Center, Barzilai Hospital, Ben Gurion University of Negev, Ashkelon, Israel.
Eli
E
Magen
Orthopedic Department, Meir Medical Center, Kfar Saba, Israel.
Viktor
V
Feldman
Medicine B Department, Barzilai Medical Center, 78306 Ashkelon, Israel.
Mishal
M
Joseph
Leumit Health Services, Ashkelon, Israel.
Hadari
H
Israel