Compensatory mutations occur within the electrostatic interaction range of deleterious mutations in protein structure.
A compensatory mutation (CM) counter balances lethal effects of a deleterious mutation (DM), ensuring the persistence of both through natural selection. However, little is known about the biological aspects of CMs those restore the structural alterations of proteins caused by slightly DMs. Here, by analyzing the evolution of the UDP-glycosyltransferase 73B4 protein among monocot-dicot plants, we investigate the occurrence of CMs around slightly DMs in 3D space. Our results illustrate that CMs exhibit significantly higher tendency to occur within the range of electrostatic interaction around the slightly DMs, compared to occurring randomly in the protein.
Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata, 700009, India.
Amrita
A
Bhattacherjee
Saurav
S
Mallik
Sudip
S
Kundu
D019143:Evolution, Molecular; D017354:Point Mutation; D011487:Protein Conformation; D055550:Protein Stability; D055672:Static Electricity