Impact of next-generation technologies on exploring socioeconomically important parasites and developing new interventions.
High-throughput molecular and computer technologies have become instrumental for systems biological explorations of pathogens, including parasites. For instance, investigations of the transcriptomes of different developmental stages of parasitic nematodes give insights into gene expression, regulation and function in a parasite, which is a significant step to understanding their biology, as well as interactions with their host(s) and disease. This chapter (1) gives a background on some key parasitic nematodes of socioeconomic importance, (2) describes sequencing and bioinformatic technologies for large-scale studies of the transcriptomes and genomes of these parasites, (3) provides some recent examples of applications and (4) emphasizes the prospects of fundamental biological explorations of parasites using these technologies for the development of new interventions to combat parasitic diseases.
Department of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC, 3010, Australia.
Cinzia
C
Cantacessi
Andreas
A
Hofmann
Bronwyn E
BE
Campbell
Robin B
RB
Gasser
D000818:Animals; D001709:Biotechnology / Q000379:methods / Q000639:trends; D019295:Computational Biology; D016208:Databases, Factual; D055808:Drug Discovery; D023281:Genomics; D006801:Humans; D009349:Nematode Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology* / Q000517:prevention & control; D010271:Parasites / Q000235:genetics*