[Development and practice evaluation of blood acid-base imbalance analysis software].
OBJECTIVE
To develop a blood gas, acid-base imbalance analysis computer software to diagnose systematically, rapidly, accurately and automatically determine acid-base imbalance type, and evaluate the clinical application.


METHODS
Using VBA programming language, a computer aided diagnostic software for the judgment of acid-base balance was developed. The clinical data of 220 patients admitted to the Second Affiliated Hospital of Guangzhou Medical University were retrospectively analyzed. The arterial blood gas [pH value, HCO(3)(-), arterial partial pressure of carbon dioxide (PaCO₂)] and electrolytes included data (Na⁺ and Cl⁻) were collected. Data were entered into the software for acid-base imbalances judgment. At the same time the data generation was calculated manually by H-H compensation formula for determining the type of acid-base imbalance. The consistency of judgment results from software and manual calculation was evaluated, and the judgment time of two methods was compared.


RESULTS
The clinical diagnosis of the types of acid-base imbalance for the 220 patients: 65 cases were normal, 90 cases with simple type, mixed type in 41 cases, and triplex type in 24 cases. The accuracy of the judgment results of the normal and triplex types from computer software compared with which were calculated manually was 100%, the accuracy of the simple type judgment was 98.9% and 78.0% for the mixed type, and the total accuracy was 95.5%. The Kappa value of judgment result from software and manual judgment was 0.935, P=0.000. It was demonstrated that the consistency was very good. The time for software to determine acid-base imbalances was significantly shorter than the manual judgment (seconds:18.14 ± 3.80 vs. 43.79 ± 23.86, t=7.466, P=0.000), so the method of software was much faster than the manual method.


CONCLUSIONS
Software judgment can replace manual judgment with the characteristics of rapid, accurate and convenient, can improve work efficiency and quality of clinical doctors and has great clinical application promotion value.
Department of Laboratory Medicine, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou 510260, Guangdong, China, Corresponding author: Huang Haiying, Email: 799961191@qq.com.
Bo
B
Chen
Haiying
H
Huang
Qiang
Q
Zhou
Shan
S
Peng
Hongyu
H
Jia
Tianxing
T
Ji
D000136:Acid-Base Equilibrium; D000137:Acid-Base Imbalance / Q000175:diagnosis*; D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D006801:Humans; D015203:Reproducibility of Results; D012984:Software
D002245:Carbon Dioxide