Magnetic seizure therapy in an adolescent with refractory bipolar depression: a case report.
Magnetic seizure therapy (MST) has shown efficacy in adult patients with treatment-resistant depression with limited impairment in memory. To date, the use of MST in adolescent depression has not been reported. Here we describe the first successful use of MST in the treatment of an adolescent patient with refractory bipolar depression. This patient received MST in an ongoing open-label study for treatment-resistant major depression. Treatments employed a twin-coil MST apparatus, with the center of each coil placed over the frontal cortex (ie, each coil centered over F3 and F4). MST was applied at 100 Hz and 100% machine output at progressively increasing train durations. Depressive symptoms were assessed using the 24-item Hamilton Depression Rating Scale and cognitive function was assessed with a comprehensive neuropsychological battery. This adolescent patient achieved full remission of clinical symptoms after an acute course of 18 MST treatments and had no apparent cognitive decline, other than some autobiographical memory impairment that may or may not be related to the MST treatment. This case report suggests that MST may be a safe and well tolerated intervention for adolescents with treatment-resistant bipolar depression. Pilot studies to further evaluate the effectiveness and safety of MST in adolescents warrant consideration.
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada.
Yoshihiro
Y
Noda
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada ; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Zafiris J
ZJ
Daskalakis
MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada.
Jonathan
J
Downar
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Paul E
PE
Croarkin
Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia.
Paul B
PB
Fitzgerald
Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada ; Temerty Centre for Therapeutic Brain Intervention, Toronto, ON, Canada ; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Daniel M
DM
Blumberger
adolescent depression; brain stimulation; cognitive effects; treatment-resistant depression