Enzymatic intracrine regulation of white adipose tissue.
Abdominal fat formation has become a permanent risk factor for metabolic syndrome and various cancers in one-third of the world's population of obese and even lean patients. Formation of abdominal fat involves additional mechanisms beyond an imbalance in energy intake and expenditure, which explains systemic obesity. In this review, we briefly summarized autonomous regulatory circuits that locally produce hormones from inactive precursors or nutrients for intra-/auto-/paracrine signaling in white adipose depots. Enzymatic pathways activating steroid and thyroid hormones in adipose depots were compared with enzymatic production of retinoic acid from vitamin A. We discussed the role of intracrine circuits in fat-depot functions and strategies to reduce abdominal adiposity through thermogenic adipocytes with interrupted generation of retinoic acid.
David
D
DiSilvestro
Jennifer
J
Petrosino
Ayat
A
Aldoori
Emiliano
E
Melgar-Bermudez
Alexandra
A
Wells
Ouliana
O
Ziouzenkova
D050153:Abdominal Fat / Q000201:enzymology / Q000378:metabolism; D017667:Adipocytes / Q000378:metabolism; D052436:Adipose Tissue, White / Q000201:enzymology* / Q000378:metabolism; D001141:Aromatase / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007453:Iodide Peroxidase / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D019899:Paracrine Communication; D015398:Signal Transduction; D014212:Tretinoin / Q000378:metabolism; D014801:Vitamin A / Q000378:metabolism
D014801:Vitamin A; D014212:Tretinoin; D007453:Iodide Peroxidase; D001141:Aromatase; D006854:Hydrocortisone