Lactobacillus brevis G101 inhibits the absorption of monosodium glutamate in mice.
To evaluate the effect of Lactobacillus brevis G-101 on absorption of monosodium glutamate (MSG), we orally administered MSG with or without G-101 in mice and measured the maximum concentration (Cmax) and blood concentration curve (AUC) of MSG and γ- aminobutyric acid (GABA). Oral administration of G-101 (1 × 10(9) CFU/mouse) potently inhibited Cmax and AUC of MSG by 97.8% and 94.3%, respectively (p < 0.05), but increased those of GABA by 32.1% and 67.7%, respectively (p < 0.05). G-101 inhibited the absorption of MSG. These results suggest that G-101 may reduce the side effect of MSG by inhibiting the absorption of MSG.
Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea, Department of Food and Nutrition, Kyung Hee University, Seoul 130-701, Republic of Korea.
Se-Eun
SE
Jang
Myung Joo
MJ
Han
Se-Young
SY
Kim
Dong-Hyun
DH
Kim
D000818:Animals; D007408:Intestinal Absorption / Q000502:physiology*; D052196:Levilactobacillus brevis / Q000502:physiology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012970:Sodium Glutamate / Q000097:blood / Q000493:pharmacokinetics*; D005680:gamma-Aminobutyric Acid / Q000097:blood* / Q000378:metabolism
D005680:gamma-Aminobutyric Acid; D012970:Sodium Glutamate