Study of behavioral parameters during learning of rats in an operant feeding task and evaluation of biochemical indexes after dietary consumption of the phytoecdysteroid extract.
Experiments on rats were performed to study the process of operant feeding learning, locomotor activity, oxygen consumption, and concentrations of corticosterone, β-endorphin, and prostaglandin E in blood serum after dietary treatment with the phytoecdysteroid extract. Administration of phytoecdysteroids was followed by the improvement of learning and increase in oxygen consumption and locomotor activity. Locomotor activity and oxygen consumption in the majority of control rats and phytoecdysteroid-treated animals were shown to be interrelated with the total locomotor activity and goal-directed operant behavior, respectively. No significant differences were found in the concentration of hormones in blood serum from animals of the control and treatment groups.
P. K. Anokhin Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia, e.murtazina@nphys.ru.
E P
EP
Murtazina
Yu S
YS
Sidorova
B V
BV
Zhuravlev
V K
VK
Mazo
S N
SN
Zorin
V V
VV
Volodin
D000284:Administration, Oral; D000818:Animals; D019659:Asteraceae / Q000737:chemistry; D003216:Conditioning, Operant / Q000187:drug effects*; D026461:Ecdysteroids / Q000008:administration & dosage*; D005247:Feeding Behavior / Q000187:drug effects*; D007858:Learning; D008297:Male; D009043:Motor Activity; D010101:Oxygen Consumption; D010936:Plant Extracts / Q000008:administration & dosage*; D017208:Rats, Wistar
D026461:Ecdysteroids; D010936:Plant Extracts