Hydrogen sulfide: an old gas with new cardioprotective effects.
Diabetic cardiovascular complications are reaching epidemic proportions and the risk of HF (heart failure) is increased 2-3-fold by diabetes mellitus. H2S (hydrogen sulfide) is emerging as a new gaseous signalling molecule in the cardiovascular system which possesses multifactorial effects on various intracellular signalling pathways. The proven cardioprotective and vasodilator activities of H2S warrant a detailed investigation into its role in diabetic cardiomyopathy. In the present issue of Clinical Science, Zhou et al. demonstrate an important therapeutic potential of the H2S pathway in diabetic cardiomyopathy.
Vaibhav B
VB
Patel
Brent A
BA
McLean
Xueyi
X
Chen
Gavin Y
GY
Oudit
D000818:Animals; D058065:Diabetic Cardiomyopathies / Q000188:drug therapy*; D006862:Hydrogen Sulfide / Q000627:therapeutic use*; D008297:Male
D006862:Hydrogen Sulfide