Synchronous bilateral non-Hodgkin's diffuse large B-cell lymphoma of the breast and left breast invasive ductal carcinoma: a case report and review of literature.
Lymphoma of the breast is unusual, and synchronous bilateral lymphoma and carcinoma of the breast is extremely rare. We present the case of a 51-year-old woman who found a mass in her left breast. Ultrasound scan findings revealed nodules at the 2 o'clock position in her left breast and focal dilation of the duct at the 8-9 o'clock and 10 o'clock position in her right and left breasts, respectively. A left breast ultrasound-guided core needle biopsy and right breast segmental excisional biopsy were performed. Pathological and immunohistochemical examination revealed left breast invasive ductal carcinoma and right breast diffuse large B-cell lymphoma of the non-germinal center type. Pathological examination of the left breast modified radical mastectomy specimen revealed synchronous invasive ductal carcinoma (grade III) and diffuse large B-cell lymphoma. The patient received chemotherapy and bone marrow transplantation in another hospital. Based on a review of the relevant literature, we discuss the diagnosis, clinical features, treatment, and prognosis of synchronous breast lymphoma and invasive ductal carcinoma.
Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
Weihua
W
Liu
Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
Hong
H
Zhu
Department of Pathology, Beijing Friendship Hospital, Capital Medical University Beijing, China.
Xiaoge
X
Zhou
D014408:Biomarkers, Tumor / Q000032:analysis; D016026:Bone Marrow Transplantation; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D015409:Mastectomy, Radical; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary; D011237:Predictive Value of Tests; D016217:Ultrasonography, Mammary
D014408:Biomarkers, Tumor
Breast lymphoma; diffuse large B-cell lymphoma; invasive ductal carcinoma; synchronous tumor