SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis.
Remodeling of the extracellular matrix is beneficial during the acute wound healing stage following tissue injury. In the short term, resident fibroblasts and myofibroblasts regulate the matrix remodeling process through production of matricellular protein components that provide structural support to the damaged tissue. This process is largely governed by the transforming growth factor-β1 (TGF-β1) pathway, a critical mediator of the remodeling process. In the long term, chronic activation of the TGF-β1 pathway promotes excessive synthesis and deposition of matrix proteins, including fibrillar collagens, which ultimately leads to organ failure. SnoN (and its alternatively-spliced isoforms SnoN2, SnoA, and SnoI) is one of four members of a family of negative regulators of TGF-β1 signaling that includes Ski and functional Smad-suppressing elements on chromosomes 15 and 18. SnoN has been shown to be structurally and functionally similar to Ski and has been demonstrated to directly interact with Ski to abrogate gene expression. Despite this, little progress has been made in delineating a specific role for SnoN in the regulation of myofibroblast phenotype and function. This review outlines the current body of knowledge of what we refer to as the "Ski-Sno superfamily," with a focus on the structural and functional importance of SnoN in mediating the fibrotic response by myofibroblasts following tissue injury.
Department of Physiology, Institute of Cardiovascular Sciences, Saint Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Matthew R
MR
Zeglinski
Department of Physiology, Institute of Cardiovascular Sciences, Saint Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Mark
M
Hnatowich
Department of Physiology, Institute of Cardiovascular Sciences, Saint Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.
Davinder S
DS
Jassal
Department of Physiology, Institute of Cardiovascular Sciences, Saint Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada idixon@sbrc.ca.
Ian M C
IM
Dixon
D000818:Animals; D003094:Collagen / Q000235:genetics / Q000378:metabolism; D005355:Fibrosis / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051785:Smad Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
D011518:Proto-Oncogene Proteins; D051785:Smad Proteins; D014157:Transcription Factors; D053773:Transforming Growth Factor beta1; D003094:Collagen
SnoN; TGF-β1; fibrosis; myofibroblast