Coagulation and mental disorders.
The neurovascular unit is a key player in brain development, homeostasis, and pathology. Mental stress affects coagulation, while severe mental illnesses, such as recurrent depression and schizophrenia, are associated with an increased thrombotic risk and cardiovascular morbidity. Evidence indicates that the hemostatic system is involved to some extent in the pathogenesis, morbidity, and prognosis of a wide variety of psychiatric disorders. The current review focuses on emerging data linking coagulation and some psychiatric disorders.
Department of Hematology, Hospital Federal dos Servidores do Estado, Ministry of Health, Rio de Janeiro, Brazil;
Silvia
S
Hoirisch-Clapauch
Institute of Psychiatry, Federal University of Rio de Janeiro, National Institute for Translational Medicine (INCT-TM), Brazil;
Antonio Egidio
AE
Nardi
Department of Haematology, Centre Hospitalier Universitaire, Nîmes, France;
Jean-Christophe
JC
Gris
Department of Hematology and Bone Marrow Transplantation, Rambam Health Care Campus and Technion Institute of Technology, Haifa, Israel.
Benjamin
B
Brenner
Anxiety; cardiovascular diseases; depression; mental disorders; schizophrenia; thrombosis