The structure of insulin at the air/water interface: monomers or dimers?
The hydrophobic character of the air/water interface affects the oligomeric composition of insulin. By using interface-specific vibrational sum frequency spectroscopy and calculations of insulin monomer and dimer second-order nonlinear susceptibilities χ((2)), we show that insulin monomers segregate to the air/water interface.
The University of Liverpool, Chemistry Department, Surface Science Research Centre, Liverpool, UK. Heike.Arnolds@liv.ac.uk.
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D000388:Air / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000737:chemistry*; D008958:Models, Molecular; D011487:Protein Conformation; D055503:Protein Multimerization; D013499:Surface Properties; D014867:Water / Q000737:chemistry
D007328:Insulin; D014867:Water