Interaction between IL-6 and TNF-α genotypes associated with bacteremia in multiple myeloma patients submitted to autologous stem cell transplantation (ASCT).
Stem cell transplantation affects patient׳s vulnerability to infections due to immunological changes related to chemotherapy. Multiple myeloma is characterized by susceptibility to infections, and IL-6 and TNF-α increased levels affect immune response (IR). Polymorphisms in promoter region of cytokine genes may alter expression levels and affect IR. We performed interaction analysis of IL-6 (-174G/C) and TNF-α (-308G/A) polymorphisms with infection susceptibility in 148 patients classified accordingly to infection status and found an interaction when compared groups with and without bacteremia (p=0.0380). The interaction may be more important than single effects for the IR associated with the infection susceptibility in ASCT.
Departament of Internal Medicine, Medicine School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Fernanda M B
FM
Trigo
Department of Pharmacology, Medicine School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Marcelo R
MR
Luizon
University Hospital, Bone Marrow Transplantation Unit, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Hélio S
HS
Dutra
University Hospital, Bone Marrow Transplantation Unit, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Angelo
A
Maiolino
University Hospital, Bone Marrow Transplantation Unit, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Márcio
M
Nucci
Departament of Internal Medicine, Medicine School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Belinda P
BP
Simões
Epistasis; Multiple myeloma; Transplantation