Enantiomerically enriched tris(boronates): readily accessible conjunctive reagents for asymmetric synthesis.
The catalytic enantioselective diboration of vinyl boronate esters furnishes chiral tris(boronates) in a selective fashion. Subsequent deborylative alkylation occurs in a diastereoselective fashion, both for intermolecular and intramolecular processes.
Department of Chemistry, Merkert Chemistry Center, Boston College , Chestnut Hill, Massachusetts 02467, United States.
John R
JR
Coombs
Liang
L
Zhang
James P
JP
Morken
D000478:Alkylation; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D007202:Indicators and Reagents / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D001897:Boronic Acids; D004952:Esters; D007202:Indicators and Reagents