The Manchester Uveitis Clinic: The first 3000 patients, 2: Uveitis Manifestations, Complications, Medical and Surgical Management.
OBJECTIVE
To demonstrate the manifestations and complications of uveitis, and their medical and surgical management, in a very large group of patients attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the Northwest of England, UK.


METHODS
Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013.


RESULTS
A total of 3000 new patients with uveitis were seen during a 22-year period, of which 25.2% had a single acute episode, 13.6% had acute recurrent uveitis, 20.2% had chronic fluctuating uveitis, and 41.0% had chronic unremitting uveitis. The commonest complications were cataract (35% of patients), macular edema (20.5%), and glaucoma (19.5%). Oral steroids were required in 36% of patients, oral immunosuppression in 16%, and biologic treatment in 2%. Major intraocular surgery was required in 28%.


CONCLUSIONS
Oral steroid usage is not an independent risk factor for cataract formation in patients with uveitis. Oral immunosuppression usage has increased 4-fold during this study period.
The Royal Eye Hospital , Manchester , United Kingdom.
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NP
Jones
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D015994:Incidence; D008269:Macular Edema / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D006113:United Kingdom / Q000453:epidemiology; D014605:Uveitis / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D014792:Visual Acuity
Cataract; complications; glaucoma; immunosuppression; macular edema; uveitis