Differential targeting of cPKC and nPKC decodes and regulates Ca²⁺ and lipid signalling.
Protein kinases C (PKCs) are ubiquitously expressed and play critical roles in a plethora of physiological and pathophysiological processes. Owing to PKCs' highly conserved phosphorylation consensus sequence, it has been difficult to distinguish the role of individual PKC isoforms. Recently, the identification of novel membrane targeting via subcellularly targeted diacylglycerol production found for novel PKCs (nPKCs), together with a characterization of their putative functions, has shed new light on the specific roles of individual PKCs in cellular processes.
*Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Medical Faculty, Saarland University, Kirrberger Strasse 100, Homburg, Saarland 66424, Germany.
Xin
X
Hui
*Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Medical Faculty, Saarland University, Kirrberger Strasse 100, Homburg, Saarland 66424, Germany.
Lars
L
Kaestner
*Molecular Cell Biology, Research Centre for Molecular Imaging and Screening, Medical Faculty, Saarland University, Kirrberger Strasse 100, Homburg, Saarland 66424, Germany.
Peter
P
Lipp
D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum; D050356:Lipid Metabolism; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction
D011493:Protein Kinase C; D002118:Calcium