Molecular evolution of kobuviruses in cats.
Aichi virus, a causative agent of human gastroenteritis, is one of a number of animal viruses belonging to the genus Kobuvirus within the family Picornaviridae. The kobuvirus genome encodes several structural and nonstructural proteins; the capsid proteins encoded by the VP1 gene are key immunogenic factors. Here, we used the VP1 region to determine substitution rates and the time to the most recent common ancestor (TMRCA) by comparing feline kobuvirus (FKoVs) sequences with kobuvirus sequences isolated from members of other species. The substitution rate for FKoVs was 1.29 × 10(-2 )substitutions/site/year (s/s/y) and the TMRCA was 5.3 years.
Animal and Plant Quarantine Agency, Anyang, Gyeonggi, 430-824, Republic of Korea.
Yoon-Young
YY
Cho
Seong-In
SI
Lim
Yong Kwan
YK
Kim
Jae-Young
JY
Song
Joong-Bok
JB
Lee
Dong-Jun
DJ
An
D000818:Animals; D001483:Base Sequence; D002415:Cats; D019143:Evolution, Molecular; D014644:Genetic Variation; D016679:Genome, Viral / Q000235:genetics; D006801:Humans; D052699:Kobuvirus / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000235:genetics*
D012367:RNA, Viral; D015678:Viral Structural Proteins