Enzyme dynamics and engineering: one step at a time.
Although protein dynamics are accepted as being essential for enzyme function, their effects are not fully understood. In this issue of Chemistry and Biology, Gobeil and coworkers describe how engineered changes in the millisecond motions of a mutant TEM-1 β-lactamase do not significantly affect substrate turnover. This mutational robustness has implications for protein engineering and design strategies.
Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Nobuhiko
N
Tokuriki
Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia. Electronic address: colin.jackson@anu.edu.au.
Colin J
CJ
Jackson
D015202:Protein Engineering; D011506:Proteins / Q000378:metabolism*
D011506:Proteins