[Non-ciliary functions of cilia proteins].
Cilia proteins have long been characterized for their role in cilia formation and function, and their implications in ciliopathies. However, several cellular defects induced by cilia proteins deregulation suggest that they could have non-ciliary roles. Indeed, several non-ciliary functions have been recently characterized for cilia proteins including roles in intra-cellular and in vesicular transport, in spindle orientation or in the maintenance of genomic stability. These observations thus raise the crucial question of the contribution of non-ciliary functions of cilia proteins to the pathological manifestations associated with ciliopathies such as polycystic kidney disease.
CNRS-CRBM (centre de recherche en biochimie macromoléculaire), équipe centrosome, cil et pathologies, université de Montpellier, 1919, route de Mende, 34293 Montpellier, France.
Nicolas
N
Taulet
CNRS-CRBM (centre de recherche en biochimie macromoléculaire), équipe centrosome, cil et pathologies, université de Montpellier, 1919, route de Mende, 34293 Montpellier, France.
Bénédicte
B
Delaval
D000818:Animals; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016825:Chlamydomonas reinhardtii / Q000235:genetics / Q000502:physiology / Q000648:ultrastructure; D020090:Chromosome Segregation / Q000502:physiology; D002925:Ciliary Motility Disorders / Q000235:genetics / Q000473:pathology; D048749:Cytokinesis / Q000502:physiology; D004260:DNA Repair / Q000502:physiology; D042822:Genomic Instability / Q000235:genetics / Q000502:physiology*; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000235:genetics / Q000473:pathology; D008322:Mammals; D008868:Microtubule Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D008938:Mitosis / Q000502:physiology; D020409:Molecular Motor Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D010641:Phenotype; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology; D021381:Protein Transport / Q000235:genetics / Q000502:physiology*; D008941:Spindle Apparatus / Q000648:ultrastructure; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000235:genetics / Q000502:physiology
D018797:Cell Cycle Proteins; D008868:Microtubule Proteins; D020409:Molecular Motor Proteins; D010940:Plant Proteins; D029961:Zebrafish Proteins