Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.
ATAD2, a remarkably conserved, yet poorly characterized factor is found upregulated and associated with poor prognosis in a variety of independent cancers in human. Studies conducted on the yeast Saccharomyces cerevisiae ATAD2 homologue, Yta7, are now indicating that the members of this family may primarily be regulators of chromatin dynamics and that their action on gene expression could only be one facet of their general activity. In this review, we present an overview of the literature on Yta7 and discuss the possibility of translating these findings into other organisms to further define the involvement of ATAD2 and other members of its family in regulating chromatin structure and function both in normal and pathological situations.
Team RNA and Epigenetics, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Matteo
M
Cattaneo
Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Yuichi
Y
Morozumi
Team RNA and Epigenetics, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Daniel
D
Perazza
Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Fayçal
F
Boussouar
Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Mahya
M
Jamshidikia
Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Sophie
S
Rousseaux
Team RNA and Epigenetics, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
André
A
Verdel
Team Epigenetics and Cell Signaling, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France ; INSERM, U823, Université Joseph Fourier - Grenoble 1, Institut Albert Bonniot, Faculté de Médecine, La Tronche Cedex, France.
Saadi
S
Khochbin
D000074183:ATPases Associated with Diverse Cellular Activities; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D016681:Genome, Fungal; D015894:Genome, Human; D056488:Histone Chaperones / Q000378:metabolism; D006801:Humans; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015533:Transcriptional Activation
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D056488:Histone Chaperones; D029701:Saccharomyces cerevisiae Proteins; C508095:YTA7 protein, S cerevisiae; D000251:Adenosine Triphosphatases; C544857:ATAD2 protein, human; D000074183:ATPases Associated with Diverse Cellular Activities
AAA ATPase; ATAD2; chromatin; histone chaperone; transcription; yeast