Resistin is not an appropriate biochemical marker to predict severity of acute pancreatitis: a case-controlled study.
OBJECTIVE
To assess levels of serum resistin upon hospital admission as a predictor of acute pancreatitis (AP) severity.


METHODS
AP is both a common and serious disease, with severe cases resulting in a high mortality rate. Several predictive inflammatory markers have been used clinically to assess severity. This prospective study collected data from 102 patients who were diagnosed with an initial acute biliary pancreatitis between March 2010 and February 2013. Measurements of body mass index (BMI) and waist circumference (WC) were obtained and serum resistin levels were analyzed at the time of hospital admission using enzyme-linked immunosorbent assay. Additionally, resistin levels were measured from a control group after matching gender, BMI and age.


RESULTS
A total of 102 patients (60 females and 42 males) were diagnosed with acute gallstone-induced pancreatitis. The mean age was 45 years, and mean BMI value was 30.5 kg/m(2) (Obese, class I). Twenty-two patients (21.6%) had severe AP, while eighty-eight patients had mild pancreatitis (78.4%). Our results showed that BMI significantly correlated with pancreatitis severity (P = 0.007). Serum resistin did not correlate with BMI, weight or WC. Furthermore, serum resistin was significantly higher in patients with AP compared to control subjects (P < 0.0001). The mean resistin values upon admission were 17.5 ng/mL in the severe acute biliary pancreatitis group and 16.82 ng/mL in the mild AP group (P = 0.188), indicating that resistin is not an appropriate predictive marker of clinical severity.


CONCLUSIONS
We demonstrate that obesity is a risk factor for developing severe AP. Further, although there is a correlation between serum resistin levels and AP at the time of hospital admission, resistin does not adequately serve as a predictive marker of clinical severity.
Hamdi Al-Maramhy, Samer Sawalhi, Department of Surgery, College of Medicine, Taibah University, Al-Madina 30001, Saudi Arabia.
Hamdi
H
Al-Maramhy
Hamdi Al-Maramhy, Samer Sawalhi, Department of Surgery, College of Medicine, Taibah University, Al-Madina 30001, Saudi Arabia.
Abdelrahman I
AI
Abdelrahman
Hamdi Al-Maramhy, Samer Sawalhi, Department of Surgery, College of Medicine, Taibah University, Al-Madina 30001, Saudi Arabia.
Samer
S
Sawalhi
D000208:Acute Disease; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000175:diagnosis; D010195:Pancreatitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D010343:Patient Admission; D011237:Predictive Value of Tests; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index; D055105:Waist Circumference
D015415:Biomarkers; D018836:Inflammation Mediators; C499624:RETN protein, human; D052243:Resistin
Acute pancreatitis; Body mass index; Resistin; Waist circumference