Glycyrrhizae radix methanol extract attenuates methamphetamine-induced locomotor sensitization and conditioned place preference.
Glycyrrhizae Radix modulates the neurochemical and locomotor alterations induced by acute psychostimulants in rodents via GABAb receptors. This study investigated the influence of methanol extract from Glycyrrhizae Radix (MEGR) on repeated methamphetamine- (METH-) induced locomotor sensitization and conditioned place preference (CPP). A cohort of rats was treated with METH (1 mg/kg/day) for 6 consecutive days, subjected to 6 days of withdrawal, and then challenged with the same dose of METH to induce locomotor sensitization; during the withdrawal period, the rats were administered MEGR (60 or 180 mg/kg/day). A separate cohort of rats was treated with either METH or saline every other day for 6 days in METH-paired or saline-paired chambers, respectively, to induce CPP. These rats were also administered MEGR (180 mg/kg) prior to every METH or CPP expression test. Pretreatment with MEGR (60 and 180 mg/kg/day) attenuated the expression of METH-induced locomotor sensitization dose-dependently, and 180 mg/kg MEGR significantly inhibited the development and expression of METH-induced CPP. Furthermore, administration of a selective GABAb receptor antagonist (SCH50911) prior to MEGR treatment effectively blocked the inhibitory effects of MEGR on locomotor sensitization, but not CPP. These results suggest that Glycyrrhizae Radix blocked repeated METH-induced behavioral changes via GABAb receptors.
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ; Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
ZhengLin
Z
Zhao
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Young Woo
0000-0002-3323-7106
YW
Kim
The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
YuPeng
0000-0001-9267-6822
Y
Yang
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
Jie
J
Zhang
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Ji Yun
JY
Jung
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Suchan
S
Chang
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Il Je
0000-0001-6295-0608
IJ
Cho
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
FuBo
F
Zhou
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China.
JunChang
J
Zhao
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Bong Hyeo
BH
Lee
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Chae Ha
CH
Yang
Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
Sang Chan
0000-0003-0515-0764
SC
Kim
Department of Pharmacology, Mudanjiang Medical University, 3 Tongxiang Street, Aimin District, Mudanjiang 157011, China ; Medical Research Center, College of Oriental Medicine, Daegu Haany University, Daegu 706-060, Republic of Korea.
RongJie
R
Zhao