Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson's Disease.
Cognitive impairment and depressive symptoms are of great interest in Parkinson's disease (PD), since they are very common and lead to increased disability with poor quality of life. Inflammatory mechanisms have been implicated in PD and its nonmotor symptoms. In the current pilot study, we aimed to evaluate plasma levels of chemokines in PD patients and to analyze the putative association of chemokines with depressive symptoms and cognitive performance. We hypothesized that higher chemokines levels are associated with worse cognitive performance and increased depressive symptoms in PD. For this purpose, 40 PD patients and 25 age- and gender-matched controls were subjected to a clinical evaluation including cognitive and mood tests. Peripheral blood was drawn and plasma levels of CCL2/MCP-1, CCL11/eotaxin, CCL24/eotaxin-2, and CXCL10/IP-10 were measured by enzyme-linked immunosorbent assay. PD patients and control individuals presented comparable plasma concentrations of all the evaluated chemokines. In PD patients, CXCL10/IP-10 plasma levels correlated positively with Hoehn and Yahr staging scale. In addition, the higher CXCL10/IP-10 levels, the worse performance on cognitive tests. Although there was no significant difference between PD patients and control individuals regarding chemokines levels, our preliminary results showed that CXCL10/IP-10 may be associated with cognitive status in PD.
Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena 190, Sala 281, 30130-100 Belo Horizonte, MG, Brazil ; Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Natália Pessoa
NP
Rocha
Laboratório de Neurobiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Paula Luciana
PL
Scalzo
Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena 190, Sala 281, 30130-100 Belo Horizonte, MG, Brazil.
Izabela Guimarães
IG
Barbosa
Departamento de Neurologia e Neurocirurgia, Santa Casa de Belo Horizonte Hospital, Avenida Francisco Sales 1111, 30150-221 Belo Horizonte, MG, Brazil.
Mariana Soares
MS
Souza
Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena 190, Sala 281, 30130-100 Belo Horizonte, MG, Brazil.
Isabela Boechat
IB
Morato
Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena 190, Sala 281, 30130-100 Belo Horizonte, MG, Brazil.
Erica Leandro Marciano
EL
Vieira
Departamento de Neurologia e Neurocirurgia, Santa Casa de Belo Horizonte Hospital, Avenida Francisco Sales 1111, 30150-221 Belo Horizonte, MG, Brazil.
Paulo Pereira
PP
Christo
Laboratório Interdisciplinar de Investigação Médica (LIIM), Faculdade de Medicina, Universidade Federal de Minas Gerais, Avenida Prof. Alfredo Balena 190, Sala 281, 30130-100 Belo Horizonte, MG, Brazil.
Antônio Lúcio
AL
Teixeira
Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Helton José
HJ
Reis