Platelet-rich fibrin plays a role on healing of acute-traumatic ear drum perforation.
OBJECTIVE
Our objective was to demonstrate the effects of platelet-rich fibrin (PRF) for the healing of acute ear drum perforation.


METHODS
Thirty-two patients with acute traumatic ear drum perforations were randomly separated into 2 groups. In group 1 (n = 14), PRF was used for the repair of ear drum perforation; in group 2 (n = 18), we did not make any intervention.


RESULTS
At initial inspection, perforation sizes were measured as 10.93 ± 3.58 mm in group 1 and 10.05 ± 4.02 mm in group 2. After 1 month, perforation sizes were 1.35 ± 2.53 mm in group 1 and 4.44 ± 3.34 mm in group 2 (P < 0.01). In the study group, the rate of ear drum closure was 64.3% and in the control group it was 22.2% (P < 0.05).


CONCLUSIONS
Here we found that PRF is a biomaterial that quickens the healing of ear drum which is autogenous and simply prepared.
From the Department of Otorhinolaryngology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Mehmet
M
Habesoglu
Cagatay
C
Oysu
Serap
S
Sahin
Asli
A
Sahin-Yilmaz
Deniz
D
Korkmaz
Ahmet
A
Tosun
Ahmet
A
Karaaslan
D000208:Acute Disease; D000328:Adult; D001792:Blood Platelets; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018058:Tympanic Membrane Perforation / Q000628:therapy*; D014945:Wound Healing; D055815:Young Adult
D005337:Fibrin