Iodide protects heart tissue from reperfusion injury.
Iodine is an elemental nutrient that is essential for mammals. Here we provide evidence for an acute therapeutic role for iodine in ischemia reperfusion injury. Infusion of the reduced form, iodide, but not the oxidized form iodate, reduces heart damage by as much as 75% when delivered intravenously following temporary loss of blood flow but prior to reperfusion of the heart in a mouse model of acute myocardial infarction. Normal thyroid function may be required because loss of thyroid activity abrogates the iodide benefit. Given the high degree of protection and the high degree of safety, iodide should be explored further as a therapy for reperfusion injury.
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, United States of America.
Akiko
A
Iwata
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, United States of America.
Michael L
ML
Morrison
Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington, United States of America.
Mark B
MB
Roth
D000284:Administration, Oral; D000818:Animals; D004452:Echocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D007454:Iodides / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology; D013960:Thyroid Function Tests; D019210:Troponin I / Q000097:blood
D007454:Iodides; D020011:Protective Agents; D019210:Troponin I