Optical coherence tomography in hydroxychloroquine retinopathy: two observational case reports.
OBJECTIVE
To describe the optical coherence tomography (OCT) findings in two cases of hydroxychloroquine retinopathy.


METHODS
Two patients with hydroxychloroquine retinopathy at the bull's eye stage were identified. Each patient underwent rigorous historical questioning to rule out known causes of macular atrophy and to determine contributing factors. Comprehensive ocular examination was performed, including dilated biomicroscopic examination of the macula and indirect ophthalmoscopic evaluation of the retinal periphery. Additional evaluation included fundus color photography with fluorescein angiography and OCT.


RESULTS
Both patients had a medical history of arthritis treated by hydroxychloroquine (Nivaquine; total dose, 365 g). At the bull's eye stage, OCT confirms the presence of macular atrophy, as shown in our two cases. The retinal atrophy seems to be related to the whole thickness of the retinal layers.


CONCLUSIONS
We report the OCT findings of two cases of macular atrophy associated with hydroxychloroquine retinopathy.
From the Department of Ophthalmology, Bordeaux University Hospital, Bordeaux, France.
Florence
F
Fontaine
Marie Benedicte
MB
Rougier
Jean Francois
JF
Korobelnik