Lymphotoxin-α keeps the gate open for T-cell infiltration in cHL.
In this issue of Blood, Fhu et al report that Reed-Sternberg cell-derived lymphotoxin-α activates endothelial cells to enhance T-cell recruitment in classical Hodgkin lymphoma (cHL), a process that is regulated by cyclooxygenase/nuclear factor-κB/activator protein 1 signaling pathways.
MAX-DELBRÜCK-CENTER FOR MOLECULAR MEDICINE.
Uta E
UE
Höpken
D015496:CD4-Positive T-Lymphocytes / Q000166:cytology*; D002450:Cell Communication / Q000276:immunology*; D042783:Endothelial Cells / Q000166:cytology*; D006689:Hodgkin Disease / Q000378:metabolism*; D006801:Humans; D008233:Lymphotoxin-alpha / Q000378:metabolism*; D016539:Reed-Sternberg Cells / Q000166:cytology*
D008233:Lymphotoxin-alpha