Outcomes of prenatally diagnosed lung lesions in multigestational pregnancies.
BACKGROUND
The outcomes of prenatally diagnosed lung lesions in the context of multigestational pregnancies are unknown.


METHODS
Of 960 fetal lung lesion cases evaluated at a single tertiary center over 16 years, 30 occurred in multigestational pregnancies. We reviewed this series to aid in prenatal counseling of affected families and to provide prognostic information for decision making. Pre- and postnatal clinical characteristics were gathered for these pregnancies, and the morbidity and mortality were determined for both affected and normal fetuses, whether twins or triplets.


RESULTS
Mortality was found to be 3/30 (10%) for affected fetuses, and morbidity in normal co-twins was consistent with the degree of prematurity. No morbidity was seen in co-twins born at or after 36 weeks of gestation. Median gestational age at delivery was 35 5/7 weeks.


CONCLUSIONS
Outcomes for the affected fetus correlate with the size and pathophysiologic consequences of the lesion and are not worse than previously reported outcomes for similar lesions in singleton pregnancies, while morbidity in the normal co-twin is consistent with prematurity related to the fetal age of the multiple gestation at delivery, irrespective of the fetal lung lesion.
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia Pa., USA.
Jesse D
JD
Vrecenak
Lori J
LJ
Howell
Nahla
N
Khalek
Julie S
JS
Moldenhauer
Mark Paul
MP
Johnson
Beverly G
BG
Coleman
Teresa
T
Victoria
Holly L
HL
Hedrick
William H
WH
Peranteau
Alan W
AW
Flake
N Scott
NS
Adzick
D000328:Adult; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D011296:Prenatal Diagnosis; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal