The association of homocysteine with metabolic syndrome in a community-dwelling population: homocysteine might be concomitant with metabolic syndrome.
OBJECTIVE
Elevated plasma total homocysteine (tHcy) and metabolic syndrome (MetS) are both associated with cardiovascular disease, but the association between tHcy and MetS is not well characterized. The aim of this study was to determine the relationship between tHcy and MetS.


METHODS
To further estimate the time-dependent association of tHcy and MetS, we analyzed the tHcy level and MetS in 1499 subjects from a 4.8-year longitudinal study in Beijing, People's Republic of China.


RESULTS
In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up. Logistic regression analysis showed that there was no association between the baseline tHcy level and MetS over the 4.8-year follow-up (odds ratio (OR), 1.32; 95% confidence interval (CI), 0.79-2.19; P = 0.282); rather, there was an association only with hypertension as a MetS component (OR, 1.53; 95% CI, 1.06-2.21; P = 0.024). tHcy levels were associated with MetS at both cross-sectional baseline (OR, 1.38; 95% CI, 1.02-1.88; P = 0.038) and cross-sectional follow-up (OR, 1.60; 95% CI, 1.02-2.50; P = 0.041). The tHcy levels of MetS subjects were higher than those of non-MetS subjects at both cross-sectional baseline (19.35 ± 7.92 µmol/L vs. 17.45 ± 6.70 µmol/L, respectively; P = 0.001) and cross-sectional follow-up (18.95 ± 7.15 µmol/L vs. 17.11 ± 5.98 µmol/L, respectively; P = 0.02).


CONCLUSIONS
The tHcy level was not predictive of the incidence of MetS; however, it may be a risk factor for hypertension as a MetS component. Furthermore, tHcy levels were associated with MetS at cross-sectional baseline and follow-up, which suggests that a higher level of tHcy might be concomitant with MetS.
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Xiaona
X
Wang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Ping
P
Ye
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Ruihua
R
Cao
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Xu
X
Yang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Wenkai
W
Xiao
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Yun
Y
Zhang
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Yongyi
Y
Bai
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
Hongmei
H
Wu
D000068476:Beijing / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012111:Residence Characteristics; D012307:Risk Factors
D015415:Biomarkers; D006710:Homocysteine