Epistasis analysis using ReliefF.
Here we introduce the ReliefF machine learning algorithm and some of its extensions for detecting and characterizing epistasis in genetic association studies. We provide a general overview of the method and then highlight some of the modifications that have greatly improved its power for genetic analysis. We end with a few examples of published studies of complex human diseases that have used ReliefF.
Department of Community and Family Medicine, Geisel School of Medicine, DHMC, One Medical Center Drive, HB 7937, Lebanon, NH, 03756, USA, Jason.H.Moore@Dartmouth.edu.
Jason H
JH
Moore
D000465:Algorithms; D004843:Epistasis, Genetic; D006801:Humans; D014397:Tuberculosis, Pulmonary / Q000235:genetics; D001749:Urinary Bladder Neoplasms / Q000235:genetics