Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection.
Toll-like receptor 7 and Myd88 are required for antiretroviral antibody and germinal center responses, but whether somatic hypermutation and class-switch recombination are required for antiretroviral immunity has not been examined. Mice deficient in activation-induced cytidine deaminase (AID) resisted Friend virus infection, produced virus-neutralizing antibodies, and controlled viremia. Passive transfer demonstrated that immune IgM from AID-deficient mice contributes to Friend virus control in the presence of virus-specific CD4+ T cells.
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan Department of Dermatology, Kinki University Faculty of Medicine, Osaka, Japan.
Maiko
M
Kato
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
Sachiyo
S
Tsuji-Kawahara
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
Yuri
Y
Kawasaki
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
Saori
S
Kinoshita
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan Unmet Medical Needs Pharma, Inc., Yokohama, Japan.
Tomomi
T
Chikaishi
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
Shiki
S
Takamura
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan.
Makoto
M
Fujisawa
Department of Dermatology, Kinki University Faculty of Medicine, Osaka, Japan.
Akira
A
Kawada
Department of Immunology, Kinki University Faculty of Medicine, Osaka, Japan masaaki@med.kindai.ac.jp.
Masaaki
M
Miyazawa
D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003564:Cytidine Deaminase / Q000172:deficiency; D005622:Friend murine leukemia virus / Q000276:immunology*; D007116:Immunization, Passive; D017578:Immunoglobulin Class Switching; D007075:Immunoglobulin M / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology* / Q000821:virology; D051379:Mice; D012192:Retroviridae Infections / Q000276:immunology* / Q000821:virology; D027041:Somatic Hypermutation, Immunoglobulin; D014412:Tumor Virus Infections / Q000276:immunology* / Q000821:virology; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007075:Immunoglobulin M; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase