Serum myeloperoxidase level is associated with heart-type fatty acid-binding protein but not troponin T in patients with chronic heart failure.
OBJECTIVE
Our aim was to investigate the possible relationship between myeloperoxidase (MPO) and myocardial damage markers such as heart-type fatty acid-binding protein (H-FABP) and troponin T (TnT) in patients with chronic heart failure (HF).


METHODS
Forty-two consecutive patients (age range: 27-80 years) with chronic HF were enrolled in the study. Serum H-FABP, TnT and MPO levels were measured. Routine biochemical and clinical parameters were recorded. Echocardiographic examinations were performed on all patients. A linear regression analysis was performed to determine the correlates of serum H-FABP.


RESULTS
The MPO, H-FABP and TnT levels were 255 ± 227, 60.6 ± 48.5 and 0.07 ± 0.15 ng/ml, respectively. In multiple linear regression analysis, age (β = -0.36, p = 0.006), creatinine level (β = 0.3, p = 0.024) and serum MPO level (β = 0.41, p = 0.009) were significant determinants of H-FABP levels. Bivariate predictors were not significantly associated with TnT levels in linear regression analyses.


CONCLUSIONS
The MPO was significantly associated with serum H-FABP levels but not with TnT.
Department of Cardiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Omer
O
Gedikli
Abdulkadir
A
Kiris
Yusuf
Y
Hosoglu
Caner
C
Karahan
Sahin
S
Kaplan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D002908:Chronic Disease; D004452:Echocardiography; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D009195:Peroxidase / Q000097:blood*; D020107:Troponin T / Q000097:blood*; D014421:Turkey
D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins; D020107:Troponin T; D009195:Peroxidase