Synthesis and in vitro cytotoxic activity of chromenopyridones.
Novel substituted chromenopyridones (3a-j and 6a-d) were synthesized and evaluated in vitro for the cytotoxic activity against various human cancer cell lines such as prostate (PC-3), breast (MCF-7), CNS (IMR-32), cervix (Hela), and liver (Hep-G2). preliminary cytotoxic screening showed that all the compounds possess a good to moderate inhibitory activity against various cancer cell lines. Particularly, compound 6b bearing allyl moiety displayed a significant cytotoxic potential in comparison to standard drugs.
Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Balwinder
B
Singh
Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Vishal
V
Sharma
Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Gagandeep
G
Singh
Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Rakesh
R
Kumar
Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Saroj
S
Arora
Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143005, India.
Mohan Paul Singh
MP
Ishar