Cytotoxic sesterterpenoids isolated from the marine sponge Scalarispongia sp.
Eight scalarane sesterterpenoids, including four new compounds, were isolated from the marine sponge Scalarispongia sp. The structures of the new compounds were elucidated by 2D-NMR and HRMS analyses. All of the isolated compounds, with the exception of 16-O-deacetyl-12,16-epi-scalarolbutanolide, showed significant in vitro cytotoxicity (GI50 values down to 5.2 μM) against six human cancer cell lines.
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea. yjlee@kiost.ac.
Yeon-Ju
YJ
Lee
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea. toyjwlee@gmail.com.
Jeong-Woo
JW
Lee
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea. trchapman@hanmail.net.
Dong-Geun
DG
Lee
Marine Natural Product Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Ansan 426-744, Korea. hslee@kiost.ac.
Hyi-Seung
HS
Lee
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 323-833, Korea. kanjon@kribb.re.kr.
Jong Soon
JS
Kang
Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon 323-833, Korea. jyun@kribb.re.kr.
Jieun
J
Yun
D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D066241:Carbon-13 Magnetic Resonance Spectroscopy; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011161:Porifera / Q000737:chemistry*; D066244:Proton Magnetic Resonance Spectroscopy; D054830:Sesterterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D054830:Sesterterpenes