Parotid gland follicular lymphoma lacking both cytoplasmic and surface light chains: a rare case.
Immunoglobulin light chain (LC) restriction is detected in the majority of B-cell non-Hodgkin lymphoma (B-NHL) by flow cytometric immunophenotyping (FCI) and serves as a surrogate marker of monoclonality. Even though it is known a small percentage of mature B-NHLs lacking surface LC, deficiency of both cytoplasmic and surface LCs has been reported in only three B-NHL cases. We report a primary parotid gland follicular lymphoma in a 63-year-old man and the lymphoma cells were deficient of cytoplasmic/surface LCs. Compared to previous reports, we used a more sensitive FCI method by combining both monoclonal and polyclonal anti-LC antibodies. Lacking LCs poses as a pitfall for the initial diagnosis of B-NHL, as well as for detecting minimal residual disease. It is important to be aware of this rare immunophenotypic aberrancy.
Department of Pathology, Loma Linda University Loma Linda, CA.
Jenny
J
Smith
Department of Pathology, University of California San Diego.
Fang
F
Wen
VA Loma Linda Healthcare System Loma Linda, CA.
Jeffrey
J
Cao
Department of Pathology, University of California San Diego ; VA San Diego Healthcare System San Diego, CA, USA.
Xiangdong
X
Xu
D014408:Biomarkers, Tumor / Q000276:immunology*; D001706:Biopsy; D002462:Cell Membrane / Q000276:immunology*; D003593:Cytoplasm / Q000276:immunology*; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007150:Immunohistochemistry; D016130:Immunophenotyping / Q000379:methods; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000276:immunology*; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000276:immunology*; D011237:Predictive Value of Tests
D014408:Biomarkers, Tumor; D007147:Immunoglobulin Light Chains
Follicular lymphoma; flow cytometry; immunoglobulin light chain; light chain negativity; parotid gland