Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients.
Ataxia telangiectasia mutated (ATM) gene is critical in the process of recognizing and repairing DNA lesions and is related to invasion and metastasis of malignancy. The incidence rate of papillary thyroid cancer (PTC) has increased for several decades and is higher in females than males. In this study, we want to investigate whether ATM polymorphisms are associated with gender-specific metastasis of PTC. 358 PTC patients in Northern China, including 109 males and 249 females, were included in our study. Four ATM single nucleotide polymorphisms (SNPs) were genotyped using Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS). Association between genotypes and the gender-specific risk of metastasis was assessed by odds ratios (OR) and 95% confidence intervals (CI) under the unconditional logistic regression analysis. Significant associations were observed between rs189037 and metastasis of PTC in females under different models of inheritance (codominant model: OR = 0.15, 95% CI 0.04-0.56, P = 0.01 for GA versus GG and OR = 0.08, 95% CI 0.01-0.74, P = 0.03 for AA versus GG, resp.; dominant model: OR = 0.49, 95% CI 0.25-0.98, P = 0.04; overdominant model: OR = 0.47, 95% CI 0.25-0.89, P = 0.02). However, no association remained significant after Bonferroni correction. Our findings suggest a possible association between ATM rs189037 polymorphisms and metastasis in female PTCs.
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Yulu
Y
Gu
Jilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Xiaoli
X
Liu
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Yaqin
Y
Yu
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Jieping
J
Shi
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Lizhe
L
Ai
Jilin Provincial Key Laboratory of Surgical Translational Medicine, Department of Thyroid and Parathyroid Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Hui
H
Sun
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Joseph Sam
JS
Kanu
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Chong
C
Wang
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China ; Jilin Provincial Key Laboratory of Molecular Epidemiology, School of Public Health, Jilin University, Changchun 130021, China.
Yawen
0000-0003-2859-4771
Y
Liu