Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population.
OBJECTIVE
The objective of this study was to assess the effect of thyroid dysfunction and autoimmunity in early pregnancy on adverse pregnancy and neonatal outcome.


METHODS
497 pregnant women between 10 and 12 gestational age were invited who were attending for their first antenatal visit and asked to perform blood tests for thyroid function and antithyroid peroxidase antibodies. A total of 395 women were recruited in the present study. Cases were classified into four groups according to thyroid function and anti-TPO results. The pregnancy outcomes included gestational diabetes mellitus, preeclampsia, preterm delivery, cesarean rate, small for gestational age, low birth weight.


RESULTS
2.5-(OR 2.5, 95% CI 1.06-5.89) and 4.8-(OR 4.85, 95% CI 1.89-12.42) fold increase in preterm delivery was detected in groups with isolated anti-TPO positivity and subclinic hypothyroidism with anti-TPO positivity compared to reference group, respectively. No association was found between thyroid dysfunction and anti-TPO positivity with gestational diabetes, preeclampsia, cesarean rates, low birth weight and small for gestational age neonates.


CONCLUSIONS
Pregnant women with anti-TPO antibody positivity alone or with subclinic hypothyroidism were more likely to experience a spontaneous preterm delivery.
Department of Perinatology, Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital, Istanbul, Turkey.
Pinar
P
Kumru
Emre
E
Erdogdu
Resul
R
Arisoy
Oya
O
Demirci
Aysen
A
Ozkoral
Cem
C
Ardic
Arif Aktug
AA
Ertekin
Sinan
S
Erdogan
Nilufer Nihan
NN
Ozdemir
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity / Q000502:physiology*; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011261:Pregnancy Trimester, First / Q000097:blood / Q000276:immunology; D011446:Prospective Studies; D012307:Risk Factors; D013959:Thyroid Diseases / Q000276:immunology / Q000503:physiopathology*; D014421:Turkey / Q000453:epidemiology
D001323:Autoantibodies; C056626:thyroid microsomal antibodies