Solid phase synthesis of functionalised SAM-forming alkanethiol-oligoethyleneglycols.
We present an efficient solid phase synthesis methodology that provides easy access to a range of functionalised long-chain alkanethiol-oligoethyleneglycols that form well-defined self-assembled monolayers on gold and are compatible with pre- or post-assembly conjugation of (bio)molecules. We demonstrate the versatility of our synthetic route by synthesising LCAT-OEGs with a range of functional moieties, including peptides, electro-active redox groups, chemical handles for post-assembly conjugation of (bio)molecules, and demonstrate the application of our LCAT-OEG monolayers in immunosensing, where they show good biocompatibility with minimal biofouling.
School of Chemistry, University of Leeds, LS2 9JT, UK ; Astbury Centre for Structural Molecular Biology, University of Leeds, UK.
James
J
Murray
Astbury Centre for Structural Molecular Biology, University of Leeds, UK ; School of Electronic and Electrical Engineering, University of Leeds, UK.
Dominika
D
Nowak
Astbury Centre for Structural Molecular Biology, University of Leeds, UK ; School of Physics and Astronomy, University of Leeds, UK.
Laurynas
L
Pukenas
Department of Electronics, University of York, Heslington York, YO10 5DD, UK.
Rizuan
R
Azhar
School of Chemistry, University of Leeds, LS2 9JT, UK.
Mathieu
M
Guillorit
School of Electronic and Electrical Engineering, University of Leeds, UK.
Christoph
C
Wälti
Astbury Centre for Structural Molecular Biology, University of Leeds, UK ; School of Physics and Astronomy, University of Leeds, UK.
Kevin
K
Critchley
Department of Electronics, University of York, Heslington York, YO10 5DD, UK.
Steven
S
Johnson
School of Chemistry, University of Leeds, LS2 9JT, UK ; Astbury Centre for Structural Molecular Biology, University of Leeds, UK.
Robin S
RS
Bon