Maternal thrombophilia and adverse pregnancy outcome: a case-control study.
OBJECTIVE
To assess the risk of adverse pregnancy outcomes in patients with acquired and/or congenital thrombophilia factors.


METHODS
A cohort of 130 women with a history of pregnancy loss and no successful gestation were investigated for the presence of congenital and acquired thrombophilia factors, and then compared with a control group of 130 healthy women who had had at least one successful gestation and no pregnancy loss, and were screened for congenital and acquired thrombophilia factors.


RESULTS
Acquired and congenital thrombophilia factors were found in 30 (23%) patients and in 14 (10.8%) controls (p < 0.015). The presence of ≥1 congenital thrombophilia factor was associated with pregnancy loss with an odds ratio of 2.46 (p = 0.040). Moreover, women who had had >1 early fetal loss had a 2.85-fold risk of being carriers of congenital thrombophilia factors, compared to the controls.


CONCLUSIONS
Our study showed the increased risk of miscarriage in patients with congenital thrombophilia factors and >1 early fetal loss.
Department of Cellular Biotechnology and Hematology, University 'Sapienza', Rome, Italy.
Maria Gabriella
MG
Mazzucconi
Vitaliana
V
De Sanctis
Marco
M
Alfò
Maria Antonietta
MA
Amendolea
Laura
L
Conti
Cristina
C
Santoro
Erminia
E
Baldacci
Monica
M
Peraino
Cesare
C
Masala
D000022:Abortion, Spontaneous / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012307:Risk Factors; D019851:Thrombophilia / Q000151:congenital / Q000175:diagnosis / Q000453:epidemiology*