Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity.
The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes. Moreover, these nonclassical MHC molecules are known to interact with CD94/NKG2 heterodimeric receptors to induce immune responses and immune regulations. This dual role of Qa-1/HLA-E in terms of innate and adaptive immunity makes them more interesting. This review highlights the new updates of the mammalian nonclassical MHC-I molecules in terms of their gene organization, evolutionary perspective and their role in immunity.
School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
B M
BM
Pratheek
School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
Tapas K
TK
Nayak
School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
Subhransu S
SS
Sahoo
Department of Zoology, Utkal University, Bhubaneswar, Odisha, India.
Prafulla K
PK
Mohanty
Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, Odisha, India.
Soma
S
Chattopadhyay
Department of Medicine, University of Connecticut Health Center, Farmington, USA.
Ntiya G
NG
Chakraborty
School of Biological Sciences, National Institute of Science Education and Research, Bhubaneswar, Odisha, India.
Subhasis
S
Chattopadhyay
CD94/NKG2; Qa-1; human leukocyte antigen-E; major histocompatibility complex