Surgery and postoperative recurrence in children with Crohn disease.
OBJECTIVE
The aim of this study was to describe surgery rates, complications, and risk of disease recurrence after surgery in paediatric Crohn disease (CD).


METHODS
Children <18 years with a diagnosis of CD and a least 1 intestinal resection from the period January 1, 1978 to December 31, 2007 were identified using the Danish National Patient Registry. Patient charts were used to extract data.


RESULTS
A total of 115 of 422 children with CD, who had surgery in 2 referral centres, were further studied. Disease extension according to the Montreal classification at the time of operation was available in 106/115 patients: B1, 39/106 (37%); B2, 59/106 (56%); and B3, 8/106 (7%). Before/after surgery 89%/36% of the patients received corticosteroids, 26%/61% azathioprine, and 15%/34% infliximab. Ileocoecal resection was performed in 54 (47%); 17 (15%) underwent ileal resection, 21 (18%) colectomy, 13 (11%) hemicolectomy, and 10 (9%) a combined colonic and ileal resection. Median time from diagnosis to surgery was 23 months (range 0-147). The median follow-up time after surgery was 121 months (16-226), and median time to disease recurrence was 12 months (3-160). The cumulative clinical recurrence rates at 1, 5, and 10 years were 50%, 73%, and 77%, respectively. More than 1 bowel resection was needed in 39%. Postoperative azathioprine treatment did not affect rate of recurrence after surgery.


CONCLUSIONS
In this large cohort of children with CD studied for >10 years postoperatively, we found a high postoperative recurrence rate of disease and a frequent need for >1 intestinal resection.
*Department of Paediatrics, Hvidovre University Hospital, Hvidovre †Department of Paediatrics and Gastrointestinal Surgery, Odense University Hospital, Odense, Denmark.
Lars F
LF
Hansen
Christian
C
Jakobsen
Anders
A
Paerregaard
Niels
N
Qvist
Vibeke
V
Wewer
D000293:Adolescent; D000328:Adult; D002432:Cecum / Q000601:surgery*; D002648:Child; D015331:Cohort Studies; D003082:Colectomy / Q000009:adverse effects*; D003131:Combined Modality Therapy / Q000009:adverse effects; D003424:Crohn Disease / Q000503:physiopathology / Q000517:prevention & control / Q000601:surgery* / Q000628:therapy; D003718:Denmark; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D059351:Organ Sparing Treatments / Q000009:adverse effects*; D010818:Practice Patterns, Physicians'; D012008:Recurrence; D012042:Registries; D012086:Reoperation / Q000009:adverse effects; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D055815:Young Adult