[White matter alterations in schizophrenia].
Schizophrenia is a brain disorder characterized by fundamental changes in thinking and beliefs. Alterations in white matter integrity may underlie the characteristic psychotic symptoms. This review focuses on diffusion tensor imaging studies in schizophrenia patients. Overall, schizophrenia appears to be associated with white matter deficits particularly in the fronto-temporal connections. To dissect potential medication effects from myelination deficits related to symptoms, longitudinal studies in initially antipsychotic-naive first-episode patients with schizophrenia are needed.
Center for Neuropsykiatrisk Skizofreniforskning CNSR & CINS, Psykiatrisk Center Glostrup, Nordre Ringvej 67, 2600 Glostrup. bebdrup@cnsr.dk.
Bjørn H
BH
Ebdrup
Nana
N
Skovgaard
Jayachandra M
JM
Raghava
Birte
B
Glenthøj
D016880:Anisotropy; D015986:Confounding Factors, Epidemiologic; D056324:Diffusion Tensor Imaging; D006801:Humans; D021621:Imaging, Three-Dimensional; D012559:Schizophrenia / Q000473:pathology*; D066127:White Matter / Q000473:pathology*