Synthesis and cell phototoxicity of a triply bridged fused diporphyrin appended with six thioglucose units.
A triply bridged fused diporphyrin appended with six thioglucose units is reported. This new, chemically and photochemically stable amphiphilic compound is taken up by breast cancer cells and causes cell death upon light exposure. Photophysical studies reveal absorption bands in the near IR region, and photosensitized formation of singlet oxygen in high quantum yields.
Department of Chemistry & Biochemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY, 10065, USA.|Department of Natural Sciences, LaGuardia Community College of The City University of New York, 31-10 Thomson Avenue, Long Island City, New York, NY 11101, USA.
Sunaina
S
Singh
Department of Chemistry & Biochemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY, 10065, USA.|Department of Natural Sciences, LaGuardia Community College of The City University of New York, 31-10 Thomson Avenue, Long Island City, New York, NY 11101, USA.
Amit
A
Aggarwal
Department of Chemistry & Biochemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY, 10065, USA.
N V S Dinesh K
NVSDK
Bhupathiraju
Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, 39211, USA.
Brandon
B
Newton
Department of Natural Sciences, LaGuardia Community College of The City University of New York, 31-10 Thomson Avenue, Long Island City, New York, NY 11101, USA.
Ahmad
A
Nafees
Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, 39211, USA.|Department of Chemistry and Physics, SUNY College at Old Westbury, Old Westbury, NY, 11568, USA.
Ruomei
R
Gao
Department of Chemistry & Biochemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY, 10065, USA.|The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
Charles Michael
CM
Drain
Click Chemistry; Fluorescence; Photodynamic Therapy; Porphyrin; Thioglucose