Vibroacustic microvibrations enhance kidney blood supply, glomerular filtration and glutathione peroxidase activity in spontaneously hypertensive rats.
Limited numbers of studies include research of microvibration therapy in experimental models. We examined effects of chronic vibroacustic-microvibration treatment on haemodynamics and anti-oxidative defense in experimental hypertension. Study was performed on chronically treated hypertensive and normotensive Wistar rats. Mean arterial pressure (MAP), cardiac output (CO), renal blood flow (RBF), glomerular filtration and activity of anti-oxidative enzymes were determined after three weeks treatment. Vibroacustic treatment had no influence on MAP and CO, but RBF was increased in both groups of treated rats. Additionally, vibroacustic treatment enhanced diuresis and increased glomerular filtration in hypertensive rats. Glutathione peroxidase (GSH-Px) activity was elevated in both treated rat strains, but activity of superoxide dismutase was unchanged. We conclude that microvibration treatment doesn't ameliorate hypertension but improves renal blood supply (trough diminished renal vascular resistance), glomerular filtration, diuresis, and enhances glutathione dependent anti-oxidant defense with more important beneficials in hypertensive animals.
Institute for Medical Research, University of Belgrade, Serbia. zokim@imi.bg.ac.rs.
Zoran
Z
Miloradović
Nevena
N
Mihailović-Stanojević
Đurđica
Đ
Jovović
Milan
M
Ivanov
Una J
UJ
Vajić
Danijela
D
Karanović
Jelica
J
Grujić Milanović
D000162:Acoustics; D000818:Animals; D000975:Antioxidants / Q000737:chemistry; D005919:Glomerular Filtration Rate; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply*; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014732:Vibration
D000975:Antioxidants; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase