Elucidating the role of neurotensin in the pathophysiology and management of major mental disorders.
Neurotensin (NT) is a neuropeptide that is closely associated with, and is thought to modulate, dopaminergic and other neurotransmitter systems involved in the pathophysiology of various mental disorders. This review outlines data implicating NT in the pathophysiology and management of major mental disorders such as schizophrenia, drug addiction, and autism. The data suggest that NT receptor analogs have the potential to be used as novel therapeutic agents acting through modulation of neurotransmitter systems dys-regulated in these disorders.
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA.
Mona M
MM
Boules
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA.
Paul
P
Fredrickson
Department of Psychiatry, University of Florida, Gainesville FL 32611, USA.
Amber M
AM
Muehlmann
Neuropsychopharmacology Laboratory, Mayo Foundation for Medical Education and Research, Mayo Clinic, Jacksonville FL 32224, USA.
Elliott
E
Richelson
addiction; animal models; antipsychotic drugs; autism spectrum disorder; neurotensin; schizophrenia