Delayed false elevation of circulating tacrolimus concentrations after cord blood transplantation in a patient with myelodysplastic syndrome.
We herein describe the case of a 60-year-old man with a history of Behçet's disease and myelodysplastic syndrome who received cord blood transplantation (CBT). The patient was given anti-thymocyte globulin conditioning and tacrolimus to prevent graft-versus-host disease. Two months after CBT, his blood Tac concentration measured by an antibody-conjugated magnetic immunoassay (ACMIA) was found to have increased >4-fold, even after the Tac treatment was stopped. This false response was caused by the interference of endogenous heterophilic antibodies with ACMIA. Therefore, physicians must be aware of possible false ACMIA results for patients with a history of autoimmune disease and/or treated by xenogeneic antibody therapy.
Department of Hematology, Kawasaki Medical School, Japan.
Kiyohito
K
Hayashi
Taizo
T
Tasaka
Tadashi
T
Hirose
Satoko
S
Furukawa
Katsunori
K
Kohguchi
Yoshiko
Y
Matsuhashi
Hideho
H
Wada
Kaoru
K
Tohyama
Takashi
T
Sugihara
D001528:Behcet Syndrome / Q000453:epidemiology; D036101:Cord Blood Stem Cell Transplantation; D016572:Cyclosporine / Q000008:administration & dosage*; D005189:False Positive Reactions; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D007118:Immunoassay; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000628:therapy*; D016559:Tacrolimus / Q000008:administration & dosage*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus