Suvorexant: something new for sleep?
Orexin, also called hypocretin, is a neuropeptide that acts on central nervous system receptors to promote arousal. Suvorexant, its receptor antagonist, generates interest as a medication to treat insomnia. Suvorexant helps in decreasing wakefulness by counteracting orexin activity. Its low side effect potential may offer considerable benefit. Compared with other sleep aids, diminished drowsiness and less cognitive dysfunction is an advantage. Now approved for clinical use, an apparent lack of rebound insomnia or drug dependence potential might make suvorexant a good choice pharmacotherapy for patients with insomnia.
Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Abhishek
A
Reddy
Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Sowmya C
SC
Puvvada
Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Satyanarayana
S
Kommisetti
Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Rif S
RS
El-Mallakh
Department of Psychiatry,University of Louisville School of Medicine,Louisville,KY,USA.
Steven
S
Lippmann
D000818:Animals; D001381:Azepines / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D000068796:Orexin Receptor Antagonists; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D014230:Triazoles / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*
D001381:Azepines; D006993:Hypnotics and Sedatives; D000068796:Orexin Receptor Antagonists; D014230:Triazoles; C551624:suvorexant
suvorexant