Treatment of ocular surface squamous neoplasia with topical Aloe vera drops.
OBJECTIVE
To report a case of ocular surface squamous neoplasia (OSSN) that resolved with topical Aloe vera eye drop treatment.


METHODS
A 64-year-old Hispanic woman with a lesion typical for OSSN in her left eye was followed up with multiple clinical examinations and ocular surface photographs to document changes over time with A. vera-based topical treatment.


RESULTS
The patient refused biopsy of her lesion and traditional treatments and, instead, initiated using A. vera eye drops 3 times daily. At follow-up visits, the lesion was noted to regress until it finally resolved 3 months after commencing treatment. No additional topical medications were used, and she has remained tumor free for 6 years.


CONCLUSIONS
Ongoing research is warranted because A. vera may represent a new therapeutic class of medications for OSSN treatment.
*Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, PA; and †Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, FL.
Mausam R
MR
Damani
Ankoor R
AR
Shah
Carol L
CL
Karp
Stephen E
SE
Orlin
D000287:Administration, Topical; D000481:Allantoin / Q000008:administration & dosage / Q000627:therapeutic use*; D000504:Aloe / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D003230:Conjunctival Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003316:Corneal Diseases / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010226:Parabens / Q000008:administration & dosage / Q000627:therapeutic use; D008517:Phytotherapy; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage / Q000627:therapeutic use
D000970:Antineoplastic Agents; D009883:Ophthalmic Solutions; D010226:Parabens; D011310:Preservatives, Pharmaceutical; D000481:Allantoin; C015358:methylparaben