Contact time periods in immunological synapse.
This paper resolves the long standing debate as to the proper time scale 〈τ〉 of the onset of the immunological synapse bond, the noncovalent chemical bond defining the immune pathways involving T cells and antigen presenting cells. Results from our model calculations show 〈τ〉 to be of the order of seconds instead of minutes. Close to the linearly stable regime, we show that in between the two critical spatial thresholds defined by the integrin:ligand pair (Δ2∼ 40-45 nm) and the T-cell receptor TCR:peptide-major-histocompatibility-complex pMHC bond (Δ1∼ 14-15 nm), 〈τ〉 grows monotonically with increasing coreceptor bond length separation δ (= Δ2-Δ1∼ 26-30 nm) while 〈τ〉 decays with Δ1 for fixed Δ2. The nonuniversal δ-dependent power-law structure of the probability density function further explains why only the TCR:pMHC bond is a likely candidate to form a stable synapse.
Non-linearity and Complexity Research Group - Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom.
Daniel R
DR
Bush
Non-linearity and Complexity Research Group - Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom.
Amit K
AK
Chattopadhyay
D054992:Immunological Synapses / Q000502:physiology*; D016023:Integrins / Q000378:metabolism; D016014:Linear Models; D008285:Major Histocompatibility Complex / Q000502:physiology; D018448:Models, Immunological; D017711:Nonlinear Dynamics; D011336:Probability; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013997:Time Factors
D016023:Integrins; D011948:Receptors, Antigen, T-Cell