Effect of Roux-en-Y gastric bypass on nonalcoholic fatty liver disease evaluated through NAFLD fibrosis score: a prospective study.
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) is common among subjects who undergo bariatric surgery and its postsurgical improvement has been reported. This study aimed to determine the evolution of liver disease evaluated through NAFLD fibrosis score 12 months after surgery.


METHODS
It is a prospective cohort study which evaluated patients immediately before and 12 months following Roux-en-Y gastric bypass (RYGB).


RESULTS
Mean score decreased from 1.142 to 0.066; surgery led to a resolution rate of advanced fibrosis of 55 %. Resolution was statistically associated with female gender, percentage of excess weight loss, postsurgical body mass index, postsurgical platelet count, and diabetes resolution.


CONCLUSIONS
As previously reported by studies in which postsurgical biopsies were performed, RYGB leads to a great resolution rate of liver fibrosis. Since postsurgical biopsy is not widely available and has a significant risk, calculation of NAFLD fibrosis score is a simple tool to evaluate this evolution through a noninvasive approach.
Department of Surgery; Faculty of Medical Sciences, State University of Campinas (UNICAMP), R. Alexander Fleming, Campinas, SP, 13083-887, Brazil, notrevezzo@yahoo.com.br.
Everton
E
Cazzo
Laísa Simakawa
LS
Jimenez
José Carlos
JC
Pareja
Elinton Adami
EA
Chaim
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D015992:Body Mass Index; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000150:complications / Q000473:pathology / Q000601:surgery*; D009767:Obesity, Morbid / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011446:Prospective Studies; D055815:Young Adult