Exudative retinal detachment as a presenting sign in Philadelphia chromosome-positive acute lymphoblastic leukemia.
OBJECTIVE
We present here a case of bilateral exudative retinal detachments in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia and describe the patient's response to induction chemotherapy and clinical course.


METHODS
A retrospective case study with fundus photographs and optical coherence tomography. A 46-year-old woman presented with bilateral exudative retinal detachments. A systemic evaluation revealed acute lymphoblastic leukemia.


CONCLUSIONS
This is an exceptional case in that the exudative retinal change so closely parallels systemic response to remission and relapse in a hematologic malignancy, and suggests that the clinical course of exudative retinal change may be a legitimate proxy for efficacy-or failure-of systemic therapy.
Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.
Matthew S J
MS
Katz
David E
DE
Fingerhut
Gowtham
G
Jonna
D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012163:Retinal Detachment / Q000209:etiology*; D012189:Retrospective Studies