The rs738409 (I148M) variant of the PNPLA3 gene and cirrhosis: a meta-analysis.
The human patatin-like phospholipase domain-containing-3 (PNPLA3) gene rs738409 C>G polymorphism is associated with several types of liver disease. The aim of this meta-analysis was to assess the risk of cirrhosis on the basis of rs738409 allele frequency and genotype. Medline, the Cochrane Library, EMBASE, and Google Scholar were searched for prospective and retrospective studies assessing the effect of the rs738409 polymorphism on liver cirrhosis. Seven studies, involving 2,023 patients with cirrhosis, were included. The G allele was associated with a significantly increased risk of cirrhosis versus the C allele [pooled odds ratio (OR) = 1.86, 95% confidence interval (CI) = 1.64-2.12, Z = 9.55, P < 0.001]. Both the GC and GG genotypes were associated with a significantly increased risk of cirrhosis versus the CC genotype (GC vs. CC: pooled OR = 1.73, 95% CI = 1.51-1.98, Z = 7.86, P < 0.001; GG vs. CC: pooled OR = 3.41, 95% CI = 2.77-4.18, Z = 11.65, P < 0.001). There was no evidence of publication bias. Our findings suggest that patients at risk for liver cirrhosis may benefit from PNPLA3 genotyping and thus more intensive monitoring if the rs738409 C>G polymorphism is identified.
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Jian-Hua
JH
Shen
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Yi-Ling
YL
Li
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Dan
D
Li
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Ning-Ning
NN
Wang
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Lei
L
Jing
Department of Gastroenterology, First Affiliated Hospital of China Medical University, ShenYang, China, 110001.
Yu-Hong
YH
Huang
D000483:Alleles; D005838:Genotype; D006801:Humans; D008049:Lipase / Q000235:genetics*; D008103:Liver Cirrhosis / Q000201:enzymology* / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
D008049:Lipase; D008565:Membrane Proteins; C533682:PNPLA3 protein, human; D000217:Acyltransferases; D054512:Phospholipases A2, Calcium-Independent
cirrhosis; patatin-like phospholipase domain-containing-3 gene; polymorphism