Evaluation of 9 rapid diagnostic tests for screening HIV infection, in Lomé, Togo.
OBJECTIVE
HIV rapid diagnostic tests (RDT) could be greatly contributive for a universal access to HIV diagnosis. However, according to the WHO, these tests need to be assessed before they can be used in routine.


RESULTS
We assessed 9 RDT in routine clinical use between 2009 and 2013. The sensitivity and specificity observed for 7 tests were≥99% and≥98%, respectively: FIRST RESPONSE HIV1-2-O PMC Medical, India, GENIE Fast HIV 1-2 and GENIE™ III HIV(1/2) Bio-Rad, France, HIV TRI-DOT+Ag;J. Mitra, INDIA; SD BIOLINE HIV(1/2) 3.0 and SD BIOLINE HIV/SYPHILIS DUO Standard Diagnostic, Korea; and VIKIA HIV(1/2); BioMérieux, France. Two tests had performances inferior to WHO recommendations: INSTI HIV1/2 Biolytical Canada; sensitivity=97.8% and HEXAGON HIV HUMAN GmbH Germany; specificity=94.8%.


CONCLUSIONS
Seven of 9 RDT had excellent performances. Nevertheless, they can be used only after training staff, and taking into account national algorithm for their safe use.
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo. Electronic address: a.dagnra@yahoo.fr.
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Dagnra
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Dossim
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Salou
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Nyasenu
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Ali-Edje
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Ouro-Médeli
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Doufan
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Ehlan
Centre national de référence pour les tests VIH/IST-PNLS, CHU Sylvanus-Olympio, 08 BP, 8742 Lomé 08, Togo.
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Prince-David
D015492:AIDS Serodiagnosis / Q000379:methods*; D000465:Algorithms; D042241:Early Diagnosis; D005188:False Negative Reactions; D005189:False Positive Reactions; D015488:HIV Antigens / Q000276:immunology; D015658:HIV Infections / Q000175:diagnosis* / Q000453:epidemiology; D015497:HIV-1 / Q000276:immunology*; D015498:HIV-2 / Q000276:immunology*; D006801:Humans; D011933:Reagent Kits, Diagnostic; D012015:Reference Standards; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013997:Time Factors; D014037:Togo / Q000453:epidemiology
D015488:HIV Antigens; D011933:Reagent Kits, Diagnostic
Dépistage; HIV; Rapid diagnostic test; Screening; Tests de diagnostic rapide