Expression of the epidermodysplasia verruciformis-associated genes EVER1 and EVER2 is activated by exogenous DNA and inhibited by LMP1 oncoprotein from Epstein-Barr virus.
EVER1 and EVER2 are mutated in epidermodysplasia verruciformis patients, who are susceptible to human betapapillomavirus (HPV) infection. It is unknown whether their products control the infection of other viruses. Here, we show that the expression of both genes in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed via activation of the NF-κB signaling pathway by latent membrane protein 1 (LMP1). Ectopic expression of EVER1 impairs the ability of EBV to infect B cells.
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Cecilia
C
Frecha
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Sébastien A
SA
Chevalier
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Patrick
P
van Uden
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Ivonne
I
Rubio
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Maha
M
Siouda
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Djamel
D
Saidj
Virus & Centromère Team, Centre de Génétique et Physiologie Moléculaire et Cellulaire, CNRS, UMR5534, Lyon, France Université de Lyon 1, Lyon, France Laboratoire d'Excellence, LabEX DEVweCAN, Lyon, France.
Camille
C
Cohen
Virus & Centromère Team, Centre de Génétique et Physiologie Moléculaire et Cellulaire, CNRS, UMR5534, Lyon, France Université de Lyon 1, Lyon, France Laboratoire d'Excellence, LabEX DEVweCAN, Lyon, France.
Patrick
P
Lomonte
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.
Rosita
R
Accardi
Section of Infections, Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France tommasino@iarc.fr.
Massimo
M
Tommasino
D001402:B-Lymphocytes / Q000821:virology; D004819:Epidermodysplasia Verruciformis / Q000473:pathology*; D005786:Gene Expression Regulation; D004854:Herpesvirus 4, Human / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D014763:Viral Matrix Proteins / Q000378:metabolism*
C037662:EBV-associated membrane antigen, Epstein-Barr virus; D008565:Membrane Proteins; C470314:TMC6 protein, human; C470315:TMC8 protein, human; D014763:Viral Matrix Proteins