[Efficacy of photodynamic antimicrobial therapy for wound flora and wound healing of pressure sore with pathogen infection].
OBJECTIVE
To explore the efficacy of photodynamic antimicrobial therapy in the treatment of pressure sore with pathogen infection.


METHODS
A total of 42 pressure sore patients with pathogen infection were divided randomly into experimental and control groups (n = 21 each). Fufanghuangbai liquid was used for external application with control group. In the experimental group, wound was treated with Fufanghuangbai liquid wet dressing and irradiated by semiconductor laser 30 min late. The distance from semiconductor laser probe to wound site was 10-15 cm, 20 min twice daily, continuous exposure to 7 days for 1 course. The results of bacterial culture and epidermal growth factor (EGF) expression of wound granulation tissue were observed before and after treatment. And the changes of healing rate of pressure sore were measured at post-treatment in each group.


RESULTS
The positive rates of bacterial culture, rates of change around wound inflammation, healing rate of days 7 and 14, the high expression of EGF on healing wound granulation tissue was 9.75%, (32.2% ± 5.8%), (89.1% ± 5.6%), (12.4% ± 2.9%), (34.7% ± 3.6%), 14/21 in the treatment group versus 51.2%, (17.8% ± 2.0%), (57.3% ± 2.6%), (5.1% ± 1.1%), (10.5% ± 2.4%), 2/21 in the control group respectively. The inter-group differences were statistically significant (P < 0.05).


CONCLUSIONS
Photodynamic antimicrobial therapy is an effective method for pressure sore with pathogen infection. Wound healing is promoted through an up-regulation of EGF.
Affiliated Laiwu Hospital, Taishan Medical College, Laiwu 271100, China. Email: lwwcl2003@163.com.
Chaoliang
C
Wang
Sufang
S
Huang
Tao
T
Zhu
Xuesheng
X
Sun
Yong
Y
Zou
Yingzhen
Y
Wang
D000890:Anti-Infective Agents; D066255:EGF Family of Proteins; D006801:Humans; D010778:Photochemotherapy; D003668:Pressure Ulcer; D015533:Transcriptional Activation; D015854:Up-Regulation; D014945:Wound Healing
D000890:Anti-Infective Agents; D066255:EGF Family of Proteins