Highly fluorescent, photostable, and ultrasmall silicon drug nanocarriers for long-term tumor cell tracking and in-vivo cancer therapy.
Silicon nanoparticle (SiNP) nanocarriers feature strong fluorescence, ultrasmall size, robust photostability, and tunable drug-loading capacity. Using SiNP nanocarriers, the first example of long-term cancer cell tracking is successfully demonstrated. Furthermore, in vivo experiments show that tumor-bearing mice treated with SiNP nanocarriers survive over 20 d without observable tumor growth, demonstrating the high-efficacy chemotherapy of the Si nanocarriers.
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China.
Xiaoyuan
X
Ji
Fei
F
Peng
Yiling
Y
Zhong
Yuanyuan
Y
Su
Xiangxu
X
Jiang
Chongxi
C
Song
Liu
L
Yang
Binbin
B
Chu
Shuit-Tong
ST
Lee
Yao
Y
He
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry; D017209:Apoptosis / Q000187:drug effects; D058948:Cell Tracking / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D005079:Excipients / Q000737:chemistry / Q000528:radiation effects; D005456:Fluorescent Dyes / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008027:Light; D061986:MCF-7 Cells; D008422:Materials Testing; D008856:Microscopy, Fluorescence / Q000379:methods; D053769:Nanocapsules / Q000528:radiation effects / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology*; D010316:Particle Size; D012825:Silicon / Q000737:chemistry / Q000528:radiation effects; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D005079:Excipients; D005456:Fluorescent Dyes; D053769:Nanocapsules; D004317:Doxorubicin; D012825:Silicon
cancer therapy; drug nanocarriers; fluorescent nanoparticles; long-term tracking