Cobalt-catalyzed C(sp(2))-H alkoxylation of aromatic and olefinic carboxamides.
The cobalt-catalyzed alkoxylation of C(sp(2) )H bonds in aromatic and olefinic carboxamides has been developed. The reaction proceeded under mild conditions in the presence of Co(OAc)2 ⋅4H2 O as the catalyst and tolerates a wide range of both alcohols and benzamide substrates, including even olefinic carboxamides. In addition, this reaction is the first example of the direct alkoxylation of alkenes through CH bond activation.
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Kexue Avenue 100, Zhengzhou, Henan 450001 (P. R. China).
Lin-Bao
LB
Zhang
Xin-Qi
XQ
Hao
Shou-Kun
SK
Zhang
Zhan-Jiang
ZJ
Liu
Xin-Xiang
XX
Zheng
Jun-Fang
JF
Gong
Jun-Long
JL
Niu
Mao-Ping
MP
Song
D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*
D000438:Alcohols; D000475:Alkenes; D000577:Amides; D006841:Hydrocarbons, Aromatic; C059688:alkoxyl radical; D003035:Cobalt
CH activation; alkoxylation; cobalt; directing groups; transition-metal catalysis