Primary localized amyloidosis of the urinary tract frequently mimics neoplasia: a clinicopathologic analysis of 11 cases.
Localized urinary tract amyloidosis (UTA) is a rare disease that mimics neoplasia clinically, cystoscopically, and radiologically. We report eleven cases of isolated UTA from the urinary bladder (n=7) and upper urinary tract including the ureter (n=2) and renal pelvis (n=2). All cases clinically presented as mass lesions prior to histologic examination and clinically suggested a neoplastic process. The amyloid composition in most cases was mixed Kappa and Lambda light chains. All cases were cured after surgical excision except one case which was diagnosed as plasmacytosis/plasmacytoma six months later. Localized amyloidosis of the urinary tract usually has a benign clinical course and simple resection is recommended after systemic disease is ruled out.
Department of Pathology, New York University Langone Medical Center TH-432, 560 First Avenue New York, NY 10016, USA.
Fang
F
Zhou
Department of Pathology, New York University Langone Medical Center TH-432, 560 First Avenue New York, NY 10016, USA.
Peng
P
Lee
Department of Pathology, New York University Langone Medical Center TH-432, 560 First Avenue New York, NY 10016, USA.
Ming
M
Zhou
Department of Pathology, New York University Langone Medical Center TH-432, 560 First Avenue New York, NY 10016, USA.
Jonathan
J
Melamed
Department of Pathology, New York University Langone Medical Center TH-432, 560 First Avenue New York, NY 10016, USA.
Fang-Ming
FM
Deng
Urinary tract amyloidosis; mimicker; neoplasia