Successful delivery of RRT in Ebola virus disease.
AKI has been observed in cases of Ebola virus disease. We describe the protocol for the first known successful delivery of RRT with subsequent renal recovery in a patient with Ebola virus disease treated at Emory University Hospital, in Atlanta, Georgia. Providing RRT in Ebola virus disease is complex and requires meticulous attention to safety for the patient, healthcare workers, and the community. We specifically describe measures to decrease the risk of transmission of Ebola virus disease and report pilot data demonstrating no detectable Ebola virus genetic material in the spent RRT effluent waste. This article also proposes clinical practice guidelines for acute RRT in Ebola virus disease.
Divisions of Pulmonary, Allergy, and Critical Care, Renal Medicine, and michael.connor@emory.edu hfranch@emory.edu.
Michael J
MJ
Connor
Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia;
Colleen
C
Kraft
Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;
Aneesh K
AK
Mehta
Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;
Jay B
JB
Varkey
Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;
G Marshall
GM
Lyon
Infectious Diseases Institute, Mulago Hospital Complex, Kampala, Uganda;
Ian
I
Crozier
US Centers for Disease Control and Prevention, Atlanta, Georgia; and.
Ute
U
Ströher
Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;
Bruce S
BS
Ribner
Renal Medicine, and Research Service, Atlanta Department of Veterans Affairs Medical Center, Decatur, Georgia michael.connor@emory.edu hfranch@emory.edu.
Harold A
HA
Franch
D058186:Acute Kidney Injury / Q000150:complications / Q000628:therapy*; D003140:Communicable Disease Control / Q000379:methods*; D006282:Health Personnel; D019142:Hemorrhagic Fever, Ebola / Q000150:complications / Q000628:therapy*; D006801:Humans; D016273:Occupational Exposure; D010356:Patient Isolation / Q000379:methods*; D061214:Patient Safety; D010865:Pilot Projects; D017410:Practice Guidelines as Topic; D060888:Real-Time Polymerase Chain Reaction; D017582:Renal Replacement Therapy / Q000379:methods*; D016896:Treatment Outcome
AKI; Ebola virus disease; biocontainment isolation; continuous RRT