Systematic analysis of immunodeficiency.
Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of specific subsets of genes after exposure to microbial stimuli in vitro.
Epinova Discovery Performance Unit, Immuno-Inflammation Therapy Area, GlaxoSmithKline R&D, Medicines Research Centre, Stevenage, UK.
David F
DF
Tough
D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology*; D053592:Interleukin-1 Receptor-Associated Kinases / Q000235:genetics* / Q000276:immunology; D008297:Male; D009154:Mutation; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics*; D000081207:Primary Immunodeficiency Diseases
C507779:MYD88 protein, human; D053594:Myeloid Differentiation Factor 88; C507773:IRAK4 protein, human; D053592:Interleukin-1 Receptor-Associated Kinases