[Myocardial protective effect of Danhong Injection evaluated by velocity vector imaging in patients undergoing percutaneous coronary intervention].
OBJECTIVE
To observe the myocardial protective effect of Danhong Injection evaluated by velocity vector imaging (VVI) in patients with unstable angina pectoris after percutaneous coronary intervention (PCI) and elucidate its possible mechanism.


METHODS
A total of 120 patients were randomized into Danhong (DG, n = 60) or control (CG, n = 60) groups. The patients in CG group received regular medication according to the guidelines while those in DG group regular medication plus Danhong Injection before and after PCI. During PCI, 40 ml Danhong Injection was administrated intravenously. The levels of CK-MB and cTnT were tested before and 24 hours after PCI. And VVI was performed before and 24 hours after PCI.


RESULTS
After treatment with Danhong injection, the serum level of MB isoenzyme of creatine kinase (CK-MB) and cardiac troponin T (cTnT) in DG were lower than those in CG (18.19 ± 10.23 vs 25.12 ± 11.91,0.079 ± 0.007 vs 0.132 ± 0.011, P < 0.05). Meanwhile, strain and strain rate of interventricular septum apex, anterior apex, inferior basement and inferior middle segment were better in DG than those in CG (26.01 ± 7.94 vs 23.25 ± 6.68, 20.91 ± 7.55 vs 18.79 ± 8.45, 18.10 ± 7.31 vs 16.89 ± 6.05, 21.16 ± 6.42 vs 18.37 ± 6.54, P < 0.05; 1.93 ± 0.79 vs 1.69 ± 0.63, 1.86 ± 0.72 vs 1.63 ± 0.68, 1.51 ± 0.80 vs 1.25 ± 0.54, 1.50 ± 0.45 vs 1.33 ± 0.32, P < 0.05 respectively).


CONCLUSIONS
Peri-procedual Danhong injection can ameliorate myocardial injury and improve segmental systolic function.
Department of Cardiology, General PLA Hospital, Beijing 100853, China.
Jing
J
Dong
Email: cyundai@medmail.com.cn.
Yundai
Y
Chen
Guang
G
Zhi
Hongxu
H
Liu
Jing
J
Wang
Feng
F
Tian
Ying
Y
Zhou
Jinsong
J
Chen
D000789:Angina, Unstable; D015415:Biomarkers; D003402:Creatine Kinase; D004365:Drugs, Chinese Herbal; D006801:Humans; D009206:Myocardium; D062645:Percutaneous Coronary Intervention
D015415:Biomarkers; D004365:Drugs, Chinese Herbal; C540581:danhong; D003402:Creatine Kinase