Remote control of signaling pathways using magnetic nanoparticles.
Our ability to quantitatively control the spatiotemporal properties of cellular information processing is key for understanding biological systems at both mechanistic and systemic level. In this context, magnetic field offers a relevant strategy of control over cellular processes that broaden the toolbox currently available in cell biology. Among the increasing number of methods, we will focus on recent advances based on magnetic nanoparticles conjugated to proteins to trigger specific signaling pathways and cellular processes. Extracellular or intracellular manipulations of nanoparticles permit magnetic control of ion channels and membrane receptor activation, protein positioning within cells and cytoskeleton spatial engineering. These approaches provide powerful strategies to examine the organization principles of living cells.
Département de Chimie, Ecole Normale Supérieure - PSL Research University, UMR 8640 - CNRS - ENS - UPMC, Paris, France.
Louise
L
Bonnemay
Céline
C
Hoffmann
Zoher
Z
Gueroui
D000818:Animals; D006801:Humans; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*; D008846:Micromanipulation / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology* / Q000528:radiation effects*
D058185:Magnetite Nanoparticles