Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility.
The Bovine Respiratory Disease Coordinated Agricultural Project (BRD CAP) is a 5-year project funded by the United States Department of Agriculture (USDA), with an overriding objective to use the tools of modern genomics to identify cattle that are less susceptible to BRD. To do this, two large genome wide association studies (GWAS) were conducted using a case:control design on preweaned Holstein dairy heifers and beef feedlot cattle. A health scoring system was used to identify BRD cases and controls. Heritability estimates for BRD susceptibility ranged from 19 to 21% in dairy calves to 29.2% in beef cattle when using numerical scores as a semi-quantitative definition of BRD. A GWAS analysis conducted on the dairy calf data showed that single nucleotide polymorphism (SNP) effects explained 20% of the variation in BRD incidence and 17-20% of the variation in clinical signs. These results represent a preliminary analysis of ongoing work to identify loci associated with BRD. Future work includes validation of the chromosomal regions and SNPs that have been identified as important for BRD susceptibility, fine mapping of chromosomes to identify causal SNPs, and integration of predictive markers for BRD susceptibility into genetic tests and national cattle genetic evaluations.
Department of Animal Science,University of California,Davis,California,USA.
Alison
A
Van Eenennaam
Department of Animal Sciences,Washington State University,Pullman,Washington,USA.
Holly
H
Neibergs
Veterinary Medicine and Biomedical Sciences,Texas A & M University,College Station,Texas,USA.
Christopher
C
Seabury
Department of Animal Sciences,University of Missouri,Columbia,Missouri,USA.
Jeremy
J
Taylor
Department of Animal Sciences,Washington State University,Pullman,Washington,USA.
Zeping
Z
Wang
Department of Animal Sciences,Washington State University,Pullman,Washington,USA.
Erik
E
Scraggs
Department of Animal Sciences,University of Missouri,Columbia,Missouri,USA.
Robert D
RD
Schnabel
Department of Animal Sciences,University of Missouri,Columbia,Missouri,USA.
Jared
J
Decker
Department of Animal Sciences,Washington State University,Pullman,Washington,USA.
Andrzej
A
Wojtowicz
Veterinary Medicine Teaching and Research Center,School of Veterinary Medicine, University of California,Davis,Tulare,California,USA.
Sharif
S
Aly
Veterinary Medicine Teaching and Research Center,School of Veterinary Medicine, University of California,Davis,Tulare,California,USA.
Jessica
J
Davis
California Animal Health and Food Safety Laboratory System,School of Veterinary Medicine, University of California,Davis,California,USA.
Patricia
P
Blanchard
California Animal Health and Food Safety Laboratory System,School of Veterinary Medicine, University of California,Davis,California,USA.
Beate
B
Crossley
Veterinary Medicine Teaching and Research Center,School of Veterinary Medicine, University of California,Davis,Tulare,California,USA.
Paul
P
Rossitto
Veterinary Medicine Teaching and Research Center,School of Veterinary Medicine, University of California,Davis,Tulare,California,USA.
Terry
T
Lehenbauer
Agricultural Science Center,New Mexico State University,Clovis,New Mexico,USA.
Robert
R
Hagevoort
Agricultural Science Center,New Mexico State University,Clovis,New Mexico,USA.
Erik
E
Chavez
School of Economic Sciences, Washington State University,Pullman,Washington,USA.
J Shannon
JS
Neibergs
Department of Molecular and Cellular Medicine,Texas A&M Health Science Center College of Medicine, Texas A&M University,Bryan,Texas,USA.
James E
JE
Womack
D000383:Agriculture; D000822:Animal Husbandry; D000818:Animals; D048090:Bovine Respiratory Disease Complex / Q000235:genetics*; D002417:Cattle; D002874:Chromosome Mapping; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D020641:Polymorphism, Single Nucleotide
D005819:Genetic Markers