Preparation of risedronate nanoparticles by solvent evaporation technique.
One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorbate, macrogol, sodium carboxymethyl cellulose and sodium carboxymethyl dextran as nanoparticle stabilizers applied in three concentrations. The prepared samples were characterized by dynamic light scattering and scanning electron microscopy. Fourier transform mid-infrared spectroscopy was used for verification of the composition of the samples. The particle size of sixteen samples was less than 200 nm. Polysorbate, sodium carboxymethyl dextran and macrogol were determined as the most favourable excipients; the particle size of the samples of risedronate with these excipients ranged from 2.8 to 10.5 nm.
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, Brno 61242, Czech Republic.
Eliska
E
Vaculikova
Nanotechnology Centre, VSB-Technical University of Ostrava, 17. listopadu 15/2172, Ostrava 70833, Czech Republic.
Daniela
D
Placha
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, Bratislava 83232, Slovakia.
Martin
M
Pisarcik
Nanotechnology Centre, VSB-Technical University of Ostrava, 17. listopadu 15/2172, Ostrava 70833, Czech Republic.
Pavlina
P
Peikertova
Nanotechnology Centre, VSB-Technical University of Ostrava, 17. listopadu 15/2172, Ostrava 70833, Czech Republic.
Katerina
K
Dedkova
Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Kalinciakova 8, Bratislava 83232, Slovakia.
Ferdinand
F
Devinsky
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, Brno 61242, Czech Republic. josef.jampilek@gmail.com.
Josef
J
Jampilek
D001682:Biological Availability; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D012968:Etidronic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D005079:Excipients / Q000737:chemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D011136:Polysorbates / Q000737:chemistry; D000068296:Risedronic Acid; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods
D003911:Dextrans; D004337:Drug Carriers; D005079:Excipients; D011136:Polysorbates; D012997:Solvents; D012967:Sodium Dodecyl Sulfate; D011092:Polyethylene Glycols; C014392:carboxymethyl dextran; D002266:Carboxymethylcellulose Sodium; D000068296:Risedronic Acid; D012968:Etidronic Acid