Management of recurrent or metastatic retroperitoneal soft-tissue sarcomas.
Retroperitoneal soft tissue sarcomas remain a serious therapeutic problem. The aim of the study is to define the optimal treatment strategy of patients with locally recurrent or metastatic retroperitoneal soft tissue sarcomas.


METHODS
A retrospective study was performed.Between 2001 and 2013, 89 patients with retroperitoneal soft tissue sarcomas were surgically treated in the University Hospital Queen Joanna ISUL and the Specialized Hospital for Active Treatment in Oncology Sofia. Clinicopathological data were investigated with SPSS 19.


RESULTS
The mean time of onset of the first and second relapse of sarcomas was 23 and 13 months, respectively. Over 40% of the studied patients underwent more than one operation because of recurrence. Ability of radical extirpation of the tumour decreased with each subsequent relapse. The 5 year survival rate was 60% for patients with primary combined radical resection versus 28% for patients with partial resection. In the presence of metastatic lesions the 3 year survival rate was only 22%.


CONCLUSIONS
Local recurrences, the presence of distant metastases and the ability of radical extirpation are the main long term prognostic factors.
D
D
Damianov
Y
Y
Asenov
P
P
Kurtev
N
N
Penkov
B
B
Korukov
P
P
Gerzilov
B
B
Golemanov
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D012189:Retrospective Studies; D012509:Sarcoma / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D016896:Treatment Outcome