Endocrine disruptors and polycystic ovary syndrome: a focus on Bisphenol A and its potential pathophysiological aspects.
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of unknown etiology that may arise from a combination of a number of underlying genetic interactions and predispositions with environmental factors. Endocrine disruptors and, in particular, Bisphenol A may represent one of the many underlying causes of the syndrome as they are experimentally linked to metabolic and reproductive derangements resembling PCOS-related disorders. Exposure to endocrine-disrupting chemicals may act as an environmental modifier to worsen symptoms of PCOS in affected females or to contribute to the final phenotype of the syndrome in genetically predisposed individuals.
Eleni
E
Palioura
Eleni
E
Kandaraki
Evanthia
E
Diamanti-Kandarakis
D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000378:metabolism; D052244:Endocrine Disruptors / Q000633:toxicity*; D005260:Female; D006801:Humans; D009490:Neurosecretory Systems / Q000187:drug effects / Q000503:physiopathology; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism; D010636:Phenols / Q000633:toxicity*; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D012098:Reproduction / Q000187:drug effects; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds