Serum HLA-G levels in women with polycystic ovary syndrome.
This study was designed to determine serum human leukocyte antigen-G (HLA-G) levels and establish whether serum HLA-G level is related with insulin resistance, oxidative stress, dyslipidemia and ovarian hyperandrogenism in women with polycystic ovary syndrome (PCOS). Twenty-five patients with PCOS and 23 healthy control women were evaluated in this study. Serum HLA-G, lipid fractions, glucose, insulin, malondialdehyde (MDA), glutathione (GSH), white blood cell (WBC), sex hormone-binding globulin (SHBG) and other hormone (gonadotropins and androgens) levels were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-IR). Serum luteinizing hormone (LH), total testosterone, fasting insulin, WBC levels and LH/follicle-stimulating hormone (FSH) ratio, free androgen index (FAI) and HOMA-IR values were significantly higher in patients with PCOS compared with healthy women. However, the women with PCOS had considerably lower serum FSH, SHBG, MDA, GSH and HLA-G levels than healthy subjects. HLA-G was inversely related with HOMA-IR, FAI, LH/FSH ratio and WBC, but positively with high-density lipoprotein cholesterol. Decreased serum HLA-G level may be related with insulin resistance, ovarian hyperandrogenism and oxidative stress in women with PCOS. Nevertheless, the exact role of HLA-G in the pathogenesis of the disease remains to be elucidated.
Department of Obstetrics and Gynecology, School of Medicine, Pamukkale University , Denizli , Turkey .
Ozer
O
Oztekin
Semin Melahat
SM
Fenkci
Veysel
V
Fenkci
Yasar
Y
Enli
Umit
U
Cabus
D000328:Adult; D015992:Body Mass Index; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D059951:HLA-G Antigens / Q000097:blood*; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D018384:Oxidative Stress / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D055815:Young Adult
D059951:HLA-G Antigens; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Insulin resistance; PCOS; ovary