Brown adipose tissue, thermogenesis, angiogenesis: pathophysiological aspects.
The number of obese and overweight individuals is globally rising, and obesity-associated disorders such as type 2 diabetes, cardiovascular disease and certain types of cancer are among the most common causes of death. While white adipose tissue is the key player in the storage of energy, active brown adipose tissue expends energy due to its thermogenic capacity. Expanding and activating brown adipose tissue using pharmacological approaches therefore might offer an attractive possibility for therapeutic intervention to counteract obesity and its consequences for metabolic health.
Jennifer
J
Honek
Sharon
S
Lim
Carina
C
Fischer
Hideki
H
Iwamoto
Takahiro
T
Seki
Yihai
Y
Cao
D002001:Adipose Tissue, Brown / Q000098:blood supply / Q000378:metabolism* / Q000503:physiopathology; D052436:Adipose Tissue, White / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism; D018919:Neovascularization, Physiologic; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D015398:Signal Transduction; D022722:Thermogenesis / Q000502:physiology*; D000071256:Uncoupling Protein 1
D007473:Ion Channels; D024101:Mitochondrial Proteins; D011943:Receptors, Adrenergic, beta; D000071256:Uncoupling Protein 1