[Study of the polymorphism R353Q in the coagulation factor VII gene and the N700S in the thrombospondin-1 gene in young patients with acute myocardial infarction].
BACKGROUND
Acute myocardial infarction is the first cause of morbidity and mortality in the world, resulting in the combination of genetic and environmental factors. It has been postulated that the R353Q polymorphism of the coagulation FVII gene represents a protective factor for acute myocardial infarction, whereas the N700S polymorphism in the thrombospondin-1 gene is associated with an increased risk for acute myocardial infarction; however, the results are still contradicted. The objective of the study was to examine the possible association of the FVII R353Q and N700S polymorphism and acute myocardial infarction in Mexican patients with acute myocardial infarction younger than 45 years old.


METHODS
Case-control study that included 252 patients who were diagnosed with acute myocardial infarction and 252 apparently healthy, age- and gender-matched individuals without a history of coronary artery disease. R353Q and N700S polymorphisms were determined in all participants by PCR-RFLP.


RESULTS
There was no statistical significant difference in genotype distribution (p = 0.06) between the acute myocardial infarction and control groups. Also, there was a similar genotype distribution of N700S polymorphism between stroke and control groups (p = 0.50). Hypertension, diabetes mellitus, family history of coronary disease and dyslipidemia represented independent risk factors for acute myocardial infarction.


CONCLUSIONS
Polymorphisms R353Q and N700S do not represent a protective or risk factor for acute myocardial infarction in young Mexican individuals.
Escuela de Ciencias Biológicas. IPN, Mexico.
María Guadalupe
MG
Valades-Mejía
Escuela de Ciencias Biológicas. IPN, Mexico.
María Lilia
ML
Domínguez-López
Servicio de Cirugía Cardiovascular, Centro Médico Nacional 20 de Noviembre, ISSSTE, Mexico.
José Luis
JL
Aceves-Chimal
Unidad de Investigación Médica en medicina Reproductiva, Unidad Médica de Alta Especialidad, Hospital de Ginecología y Obstetricia núm. 4, IMSS, Mexico.
Alfredo Leaños
AL
Miranda
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Hospital General Regional Dr Carlos Mac Gregor Sánchez Navarro, IMSS, Mexico.
Abraham
A
Majluf-Cruz
Unidad de Investigación Médica en Trombosis, Hemostasia y Aterogénesis, Hospital General Regional Dr Carlos Mac Gregor Sánchez Navarro, IMSS, Mexico. irmaisordia@yahoo.com.mx.
Irma
I
Isordia-Salas
D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D005167:Factor VII / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D009203:Myocardial Infarction / Q000235:genetics*; D011110:Polymorphism, Genetic; D019700:Thrombospondin 1 / Q000235:genetics*
D019700:Thrombospondin 1; D005167:Factor VII
Coagulation FVII; acute myocardial infarction; factor VII de la coagulación; infarto agudo de miocardio; polimorfismo; polymorphism; thrombospondin-1; trombospondina-1