Spectrum-effect relationships as a systematic approach to traditional chinese medicine research: current status and future perspectives.
Component fingerprints are a recognized method used worldwide to evaluate the quality of traditional Chinese medicines (TCMs). To foster the strengths and circumvent the weaknesses of the fingerprint technique in TCM, spectrum-effect relationships would complementarily clarify the nature of pharmacodynamic effects in the practice of TCM. The application of the spectrum-effect relationship method is crucial for understanding and interpreting TCM development, especially in the view of the trends towards TCM modernization and standardization. The basic requirement for using this method is in-depth knowledge of the active material basis and mechanisms of action. It is a novel and effective approach to study TCMs and great progress has been made, but to make it more accurate for TCM research purposes, more efforts are needed. In this review, the authors summarize the current knowledge about the spectrum-effect relationship method, including the fingerprint methods, pharmacodynamics studies and the methods of establishing relationships between the fingerprints and pharmacodynamics. Some speculation regarding future perspectives for spectrum-effect relationship approaches in TCM modernization and standardization are also proposed.
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. xuguanling4004@163.com.
Guan-Ling
GL
Xu
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. xiemeng0819@163.com.
Meng
M
Xie
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. yaner1888@163.com.
Xiao-Yan
XY
Yang
Pharmacy College, Ningxia Medical University, Ningxia 750000, China. songyan200714@163.com.
Yan
Y
Song
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 13269650940@163.com.
Cheng
C
Yan
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18311242015@163.com.
Yue
Y
Yang
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. zhangxia0561@126.com.
Xia
X
Zhang
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. lzz332@126.com.
Zi-Zhen
ZZ
Liu
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. tianyuxin1216@163.com.
Yu-Xin
YX
Tian
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18739908461@163.com.
Yan
Y
Wang
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. jiangrui54264@126.com.
Rui
R
Jiang
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. liuweirui2012@126.com.
Wei-Rui
WR
Liu
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. bucm_pharm@126.com.
Xiao-Hong
XH
Wang
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. shegaimei@126.com.
Gai-Mei
GM
She
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D008516:Medicine, Chinese Traditional / Q000379:methods*; D012015:Reference Standards; D012106:Research
D004365:Drugs, Chinese Herbal