Multicentric castleman disease with ocular involvement: a clinicopathologic case report.
OBJECTIVE
To describe an ocular manifestation of Castleman disease, a rare lymphoproliferative disorder characterized by sheets of abundant plasma cells in the interfollicular spaces of lymph nodes, most commonly in the abdomen, mediastinum, and cervical chain.


METHODS
Clinicopathologic case report.


METHODS
A 69-year-old man with lymphadenopathy and bilateral choroidal infiltrates.


RESULTS
Initially, we suspected systemic lymphoma with ocular involvement. Lymph node biopsy revealed Castleman disease without a monoclonal component. Choroidal biopsy showed lymphocytic and plasma cell infiltration.


CONCLUSIONS
To our knowledge, this is the first clinicopathologic report of multicentric Castleman disease involving the eye.
From the *Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; the †Department of Pathology and Medicine, Oregon Health & Science University, Portland, Oregon; and ‡Health Associates of Peace Harbor, Florence, Oregon.
Geoffrey G
GG
Emerson
Lyndell
L
Lim
Marc
M
Loriaux
Hazem M
HM
Yassin
Christina J
CJ
Flaxel
Justine R
JR
Smith
David J
DJ
Wilson